Saccharomyces cerevisiae S288C chromosome IV, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome IV, complete sequence.
sequence version: NC_001136.10
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001136.10
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169867
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
reference: 8
reference: 9
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006938.\n\nOn Apr 26, 2011 this sequence version replaced NC_001136.9.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000340
sequence length: 1531933
topology: linear
so has quality: SO_0000987
location: 1..1531933
location: region:1-1531933:1
RO_0002162: 559292

NC_001136
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
author: Jacq, C.
author: Alt-Morbe, J.
author: Andre, B.
author: Arnold, W.
author: Bahr, A.
author: Ballesta, J.P.
author: Bargues, M.
author: Baron, L.
author: Becker, A.
author: Biteau, N.
author: Blocker, H.
author: Blugeon, C.
author: Boskovic, J.
author: Brandt, P.
author: Bruckner, M.
author: Buitrago, M.J.
author: Coster, F.
author: Delaveau, T.
author: del Rey, F.
author: Dujon, B.
author: Eide, L.G.
author: Garcia-Cantalejo, J.M.
author: Goffeau, A.
author: Gomez-Peris, A.
author: Zaccaria, P. et al.
journal: Nature 387 (6632 SUPPL), 75-78 (1997)
pubmed: 9169867

9169867
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

7
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

8
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

9
title: Direct Submission
journal: Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1531933:1
position: 1531933
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-1531933:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: IV

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL04L; Telomeric region on the left arm of Chromosome IV; composed of an X element core sequence, X element combinatorial repeats, and a terminal stretch of telomeric repeats
so part of: sequence
location: complement(1..904)
location: region:1-904:-1
so has part: feature:1-904:-1:region

S000028875
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:904:-1
position: 904
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-904:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS400; Autonomously Replicating Sequence
so part of: sequence
location: 137..1392
location: region:137-1392:1
so has part: feature:137-1392:1:region

S000121226
type: SGD
SIO_000068: sgd

position:137:1
position: 137
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1392:1
position: 1392
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137-1392:1:region

YDL248W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COS7
locus tag: YDL248W
so part of: sequence
location: <1802..>2953
location: region:1802-2953:1
so has part: feature:1802-2953:1:exon
subclass of: SO_0000010

851348
type: Gene
SIO_000068: ncbigene

position:1802:1
position: 1802
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:2953:1
position: 2953
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1802-2953:1:exon

YDL248W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COS7
locus tag: YDL248W
product: Cos7p
transcript id: NM_001180308.1
SIO_010081: YDL248W
subclass of: SO_0000673
so part of: YDL248W
location: <1802..>2953
location: region:1802-2953:1
so has part: feature:1802-2953:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:1802-2953:1:exon

YDL248W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COS7
locus tag: YDL248W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:mutant phenotype:GO:0038024 cargo receptor activity [PMID:9560393]
note: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Cos7p
translation: MKENEVKDEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEITENTPSSDPHDWEVVVANLNSYLYENKAWNTKNFFFNATDCEKMFRTTVLEPFSLKKDKAAKVKSFKDSVPYIEEALQVYATGFDKQWKLFITEKSWSPVGLEDVQLPKDIHRSKLTWFLKRIFTIYSLPLWLAFLNCICVSQHFCLAFRILCPGLFFLMMVWLFQNMRTTALLVKMEHKMQFLLTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFDGIDCEWFFSHFFYRLLSAKKSMWLLPLNVELWPYIKEAQLSRNEESLMKK
SIO_010081: YDL248W
subclass of: SO_0000673
so part of: YDL248W
location: 1802..2953
location: region:1802-2953:1
so has part: feature:1802-2953:1:exon

NP_010033.1
type: Protein
SIO_000068: ncbiprotein

S000002407
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:1802-2953:1:exon

YDL247W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MPH2
locus tag: YDL247W
so part of: sequence
location: <5985..>7814
location: region:5985-7814:1
so has part: feature:5985-7814:1:exon
subclass of: SO_0000010

851350
type: Gene
SIO_000068: ncbigene

position:5985:1
position: 5985
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:7814:1
position: 7814
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5985-7814:1:exon

YDL247W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MPH2
locus tag: YDL247W
product: alpha-glucoside permease
transcript id: NM_001180307.1
SIO_010081: YDL247W
subclass of: SO_0000673
so part of: YDL247W
location: <5985..>7814
location: region:5985-7814:1
so has part: feature:5985-7814:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:5985-7814:1:exon

YDL247W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MPH2
locus tag: YDL247W
experiment: EXISTENCE:direct assay:GO:0005363 maltose transmembrane transporter activity [PMID:12210897]
experiment: EXISTENCE:direct assay:GO:0008643 carbohydrate transport [PMID:12210897]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:12210897]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; almost identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication
codon start: 1
product: alpha-glucoside permease
translation: MKNLSFLINRRKENTSDSNVYPGKAKSHEPSWIEMDDQTKKDGLDIVHVEFSPDTRAPSDSNKVITEIFDATEDAKEADESERGMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQRKFGSQNDKTGEWEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAFTFILYFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNSQKKYADSELGYKLPFALQWILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQATCGSILIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLAFQTIVFFIIGGLGCSSTHGSKMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVDLPETAGKTFVEINELFKLGVSARKFKSTKVDPFVVKTPLKTSLITTPREISKLPLQRNSNVSHHL
SIO_010081: YDL247W
subclass of: SO_0000673
so part of: YDL247W
location: 5985..7814
location: region:5985-7814:1
so has part: feature:5985-7814:1:exon

NP_010034.1
type: Protein
SIO_000068: ncbiprotein

S000002406
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:5985-7814:1:exon

YDL246C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOR2
locus tag: YDL246C
so part of: sequence
location: complement(<8683..>9756)
location: region:8683-9756:-1
so has part: feature:8683-9756:-1:exon
subclass of: SO_0000010

851351
type: Gene
SIO_000068: ncbigene

position:8683:-1
position: 8683
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:9756:-1
position: 9756
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:8683-9756:-1:exon

YDL246C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOR2
locus tag: YDL246C
product: L-iditol 2-dehydrogenase SOR2
transcript id: NM_001180306.1
SIO_010081: YDL246C
subclass of: SO_0000673
so part of: YDL246C
location: complement(<8683..>9756)
location: region:8683-9756:-1
so has part: feature:8683-9756:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:8683-9756:-1:exon

YDL246C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOR2
locus tag: YDL246C
EC number: 1.1.1.9
experiment: EXISTENCE:mutant phenotype:GO:0003939 L-iditol 2-dehydrogenase activity [PMID:26996892]
note: Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase
codon start: 1
product: L-iditol 2-dehydrogenase SOR2
translation: MSQNSNPAVVLEKVGDIAIEQRPIPTIKDPHYVKLAIKATGICGSDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSDETKEGSYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGVHSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATNTFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVGMGKNYTNFPIAEVSGKEMKLIGCFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDAAKAYDYNIAHGGEVVKTIIFGPE
SIO_010081: YDL246C
subclass of: SO_0000673
so part of: YDL246C
location: complement(8683..9756)
location: region:8683-9756:-1
so has part: feature:8683-9756:-1:exon

NP_010035.1
type: Protein
SIO_000068: ncbiprotein

S000002405
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:8683-9756:-1:exon

YDL245C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HLT2
gene: HXT15
locus tag: YDL245C
gene synonym: HLT2
so part of: sequence
location: complement(<11657..>13360)
location: region:11657-13360:-1
so has part: feature:11657-13360:-1:exon
subclass of: SO_0000010

851352
type: Gene
SIO_000068: ncbigene

position:11657:-1
position: 11657
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:13360:-1
position: 13360
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:11657-13360:-1:exon

YDL245C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HLT2
gene: HXT15
locus tag: YDL245C
gene synonym: HLT2
product: hexose transporter HXT15
transcript id: NM_001180305.1
SIO_010081: YDL245C
subclass of: SO_0000673
so part of: YDL245C
location: complement(<11657..>13360)
location: region:11657-13360:-1
so has part: feature:11657-13360:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:11657-13360:-1:exon

YDL245C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HLT2
gene: HXT15
locus tag: YDL245C
gene synonym: HLT2
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]
experiment: EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]
experiment: EXISTENCE:genetic interaction:GO:1902341 xylitol transmembrane transport [PMID:26996892]
experiment: EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0005355 glucose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]
note: Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose
codon start: 1
product: hexose transporter HXT15
translation: MASEQSSPEINADNLNSSAADVHVQPPGEKEWSDGFYDKEVINGNTPDAPKRGFLGYLIIYLLCYPVSFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIECERHEEACVSIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSKAMSISTAFNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEEIQLLYEEGIKPWKSASWVPPSRRGASSRETEAKKKSWKEVLKFPKSFN
SIO_010081: YDL245C
subclass of: SO_0000673
so part of: YDL245C
location: complement(11657..13360)
location: region:11657-13360:-1
so has part: feature:11657-13360:-1:exon

NP_010036.1
type: Protein
SIO_000068: ncbiprotein

S000002404
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:11657-13360:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS403; Autonomously Replicating Sequence
so part of: sequence
location: 15493..15739
location: region:15493-15739:1
so has part: feature:15493-15739:1:region

S000118427
type: SGD
SIO_000068: sgd

position:15493:1
position: 15493
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:15739:1
position: 15739
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:15493-15739:1:region

YDL244W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THI13
locus tag: YDL244W
so part of: sequence
location: <16204..>17226
location: region:16204-17226:1
so has part: feature:16204-17226:1:exon
subclass of: SO_0000010

851353
type: Gene
SIO_000068: ncbigene

position:16204:1
position: 16204
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:17226:1
position: 17226
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:16204-17226:1:exon

YDL244W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THI13
locus tag: YDL244W
product: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
transcript id: NM_001180304.1
SIO_010081: YDL244W
subclass of: SO_0000673
so part of: YDL244W
location: <16204..>17226
location: region:16204-17226:1
so has part: feature:16204-17226:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:16204-17226:1:exon

YDL244W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THI13
locus tag: YDL244W
experiment: EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]
note: Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP
codon start: 1
product: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
translation: MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDIAILEPTNPSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITEDFQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGKIDAGIGIECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVRKFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQYQRCYAYFSSSLYNVHRDWKKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFKRLALPA
SIO_010081: YDL244W
subclass of: SO_0000673
so part of: YDL244W
location: 16204..17226
location: region:16204-17226:1
so has part: feature:16204-17226:1:exon

NP_010037.1
type: Protein
SIO_000068: ncbiprotein

S000002403
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:16204-17226:1:exon

YDL243C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAD4
locus tag: YDL243C
so part of: sequence
location: complement(<17577..>18566)
location: region:17577-18566:-1
so has part: feature:17577-18566:-1:exon
subclass of: SO_0000010

851354
type: Gene
SIO_000068: ncbigene

position:17577:-1
position: 17577
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:18566:-1
position: 18566
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:17577-18566:-1:exon

YDL243C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAD4
locus tag: YDL243C
product: putative aryl-alcohol dehydrogenase
transcript id: NM_001180303.1
SIO_010081: YDL243C
subclass of: SO_0000673
so part of: YDL243C
location: complement(<17577..>18566)
location: region:17577-18566:-1
so has part: feature:17577-18566:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:17577-18566:-1:exon

YDL243C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAD4
locus tag: YDL243C
experiment: EXISTENCE:direct assay:GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity [PMID:29079624]
note: Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family
codon start: 1
product: putative aryl-alcohol dehydrogenase
translation: MGSMNKEQAFELLDAFYEAGGNCIDTANSYQNEESEIWIGEWMKSRKLRDQIVIATKFTGDYKKYEVGGGKSANYCGNHKHSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERKKNGEGLRTVSGTSKQTDKEVKISEALAKVAEEHGTESVTAIAIAYVRSKAKNVFPLVGGRKIEHLKQNIEALSIKLTPEQIEYLESIIPFDVGFPTNFIGDDPAVTKKASLLTAMSAQISFD
SIO_010081: YDL243C
subclass of: SO_0000673
so part of: YDL243C
location: complement(17577..18566)
location: region:17577-18566:-1
so has part: feature:17577-18566:-1:exon

NP_010038.1
type: Protein
SIO_000068: ncbiprotein

S000002402
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:17577-18566:-1:exon

YDL242W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL242W
so part of: sequence
location: <18959..>19312
location: region:18959-19312:1
so has part: feature:18959-19312:1:exon
subclass of: SO_0000010

851355
type: Gene
SIO_000068: ncbigene

position:18959:1
position: 18959
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:19312:1
position: 19312
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:18959-19312:1:exon

YDL242W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL242W
product: uncharacterized protein
transcript id: NM_001348898.1
SIO_010081: YDL242W
subclass of: SO_0000673
so part of: YDL242W
location: <18959..>19312
location: region:18959-19312:1
so has part: feature:18959-19312:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:18959-19312:1:exon

YDL242W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL242W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MNLEESQSNRGTLNIKKILVIVCMTNKICKHLIQSLLLSKRRLVSVLFDNYQGDMKLRSSPSAIPLVPSTKILQAMEARNDIVDSLIINSHATESDRRTLGDHEVRQCEDTNFGFKI
SIO_010081: YDL242W
subclass of: SO_0000673
so part of: YDL242W
location: 18959..19312
location: region:18959-19312:1
so has part: feature:18959-19312:1:exon

NP_001335753.1
type: Protein
SIO_000068: ncbiprotein

S000002401
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:18959-19312:1:exon

YDL241W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL241W
so part of: sequence
location: <20635..>21006
location: region:20635-21006:1
so has part: feature:20635-21006:1:exon
subclass of: SO_0000010

851356
type: Gene
SIO_000068: ncbigene

position:20635:1
position: 20635
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:21006:1
position: 21006
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:20635-21006:1:exon

YDL241W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL241W
product: uncharacterized protein
transcript id: NM_001180301.1
SIO_010081: YDL241W
subclass of: SO_0000673
so part of: YDL241W
location: <20635..>21006
location: region:20635-21006:1
so has part: feature:20635-21006:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:20635-21006:1:exon

YDL241W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL241W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDL241W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MNVTENALLFKCGSKGYINQTYTPTEIYNCGVAEGKKTAKEKNPTYSIFYDTFLTGQPAESPETFTCGSHGFTNASYVASDFYACGFLQGKGTETNAGIHNTRPSHSLAKFTILFMLVLYTIV
SIO_010081: YDL241W
subclass of: SO_0000673
so part of: YDL241W
location: 20635..21006
location: region:20635-21006:1
so has part: feature:20635-21006:1:exon

NP_010040.1
type: Protein
SIO_000068: ncbiprotein

S000002400
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:20635-21006:1:exon

YDL240W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LRG1
locus tag: YDL240W
so part of: sequence
location: <22823..>25876
location: region:22823-25876:1
so has part: feature:22823-25876:1:exon
subclass of: SO_0000010

851358
type: Gene
SIO_000068: ncbigene

position:22823:1
position: 22823
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:25876:1
position: 25876
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:22823-25876:1:exon

YDL240W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LRG1
locus tag: YDL240W
product: GTPase-activating protein LRG1
transcript id: NM_001180300.2
SIO_010081: YDL240W
subclass of: SO_0000673
so part of: YDL240W
location: <22823..>25876
location: region:22823-25876:1
so has part: feature:22823-25876:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:22823-25876:1:exon

YDL240W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LRG1
locus tag: YDL240W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11447600]
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:15514049]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11447600]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11447600|PMID:23613772|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23613772]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:15514049]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:15514049]
experiment: EXISTENCE:genetic interaction:GO:0000755 cytogamy [PMID:15514049]
experiment: EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:11447600|PMID:11713681]
experiment: EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:11447600|PMID:11713681]
experiment: EXISTENCE:genetic interaction:GO:0090038 negative regulation of protein kinase C signaling [PMID:11713681]
experiment: EXISTENCE:genetic interaction:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:11447600]
experiment: EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:15514049]
experiment: EXISTENCE:mutant phenotype:GO:0035024 negative regulation of Rho protein signal transduction [PMID:11713681]
experiment: EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:11713681]
experiment: EXISTENCE:mutant phenotype:GO:0090038 negative regulation of protein kinase C signaling [PMID:11713681]
note: GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains
codon start: 1
product: GTPase-activating protein LRG1
translation: MIQNSAGYRSLNTASPMTVQVKNQKKICARCNKLVIPDSQRTKTTLKALGKYYHESCFTCQDCQKPLKPKYFPYQVDKTSESILLCQYDYFRRHNLLCHVCDTPLRGLYYTAFGYRYDEEHFSCTICATPCGVKKCFMYGNQLYCKYHFLKYFSKRCKGCEFPISDQYIEFPKGEEIHCWHPECYGIHKYWHVNLAAETVGLQYLPKLEYNPNSGDKDINPTAYELDKQMQAFNFILSKTWSVLYRFEEEAASCISDMFQYLTSNDQLKGIESTGLLVLKIDCLFRGLDTLNLSTNKSMPVNSDQECIENNAMAASKYSKFPKNLSTKIMIYLQLLRKLGTENKNETITISSFMSVITGLAHFLKLLTRFGLYTALENNKLTHSVNPLLRFLREVEKNELFENNPFQYIKTPVNATDSCAGCNKYIQEECIQFYEHRWHIACFTCSSCHKNINPRSLTDPTFNKEKKKILCSHCSIDDPASVPGFKFVTKLAQLIFLLKIALVKSRTVMLKSKASNKVGRNSLQSTMLKEQTYIRTLNDIKRLRSRRESVRVTHNKQQARKSVILETAETDLNDPTKQGDSKNLVIQTDDPSSSQQVSTRENVFSNTKTLTLDDISRIVAAEQARELRPNAFAHFKKLKETDDETSNVVPKKSGVYYSELSTMELSMIRAISLSLLAGKQLISKTDPNYTSLVSMVFSNEKQVTGSFWNRMKIMMSMEPKKPITKTVFGAPLDVLCEKWGVDSDLGVGPVKIRIPIIIDELISSLRQMDMSVEGIFRKNGNIRRLRELTANIDSNPTEAPDFSKENAIQLSALLKKFIRELPQPILSTDLYELWIKAAKIDLEDEKQRVILLIYSLLPTYNRNLLEALLSFLHWTSSFSYIENEMGSKMDIHNLSTVITPNILYLRHKEISNDNVPDEPESGLVDSFAQNKGENYFLAIEIVDYLITHNEEMAMVPKFLMNLLKDVQLQKLDNYESINHFISTVMQSKTIDYSECDIKTPVTVKDSTTTVIQGEINK
SIO_010081: YDL240W
subclass of: SO_0000673
so part of: YDL240W
location: 22823..25876
location: region:22823-25876:1
so has part: feature:22823-25876:1:exon

NP_010041.2
type: Protein
SIO_000068: ncbiprotein

S000002399
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:22823-25876:1:exon

YDL239C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADY3
locus tag: YDL239C
so part of: sequence
location: complement(<26403..>28775)
location: region:26403-28775:-1
so has part: feature:26403-28775:-1:exon
subclass of: SO_0000010

851359
type: Gene
SIO_000068: ncbigene

position:26403:-1
position: 26403
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:28775:-1
position: 28775
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26403-28775:-1:exon

YDL239C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADY3
locus tag: YDL239C
product: Ady3p
transcript id: NM_001180299.2
SIO_010081: YDL239C
subclass of: SO_0000673
so part of: YDL239C
location: complement(<26403..>28775)
location: region:26403-28775:-1
so has part: feature:26403-28775:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26403-28775:-1:exon

YDL239C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADY3
locus tag: YDL239C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:11742972|PMID:11973299]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:11742972|PMID:11973299]
experiment: EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:11742972|PMID:11973299|PMID:24390141]
experiment: EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:17905927]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:17905927]
experiment: EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11973299]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:11742972]
experiment: EXISTENCE:physical interaction:GO:0005816 spindle pole body [PMID:11973299]
note: Protein required for spore wall formation; subunit of leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms ring-like structure at leading edge of prospore membrane during meiosis II; mediates assembly of LEP complex, formation of ring-like structure via interaction with spindle pole body components, and prospore membrane maturation; also detected in peroxisomes; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
codon start: 1
product: Ady3p
translation: MNHWLAFLNKPESLKEQNSDCDQQGEMRHVTDGTLTKSPESKPFRERRSQTWIDSEVPTSTEKSNVQESISSDIISKLSNRRSRRNRSESWAGSEASSPSGNISTLENATEKNTLKSPNKFLQRGGLPTVGIGSQALSPAGKPSTLGNVSPGKFTTYKVHNSIEVNRFSSTPTKLLTNPHKVAAISNDEHYVVSNESLEENIEVAHLENVFRSSKTPDEEQSEYMKLGEIRLSSSSYGGSISKENSLPKVLDELQSQNEEIKALRQKLEEKDDRIQELEELNSMNDAKLQRIEDLQKEFHNERKAASKRLNIVQDRFRKEIKKIREEKITDFQNKNASKKEKNEVTSAKTKCKAFSQRNILVSELYRKQKQILNLQQENDKFLKDINESNNSIVKLRSEVEILKSNLQLSQDENKKLHDNGSFYEKRLNDVYSYMQNLSLFEKDLGKFILEEMKCGHSPSMFQNGFAKLYPDFQDIKNLENMEQYKQLKGKIELLEKNDRIRLEKIISVFKLINERLHFMQQQHSHKIKYLQKEALTKEQQFRLEKRRWHDILNLKEENFQKLKSELKEKLILSEKIQKNAEDKLNDYMNEHQEIVEKLQNQALIASRWSTQIQESENTHKKITDELAGKQSEILKLEETILSLKEDVFQEKLNLKKLYGDPSTELNFETVGKSFPHITKEKYDSLGLDILTDLTYVQSQNLIKNLLIVLDIPLKTFLKIVPTIVIQLRCELTLLTKFANDLNLKVFGKQLDFKSRRKVAMNEFLNNHDIAEVKHPLEYDLQALFKYFFS
SIO_010081: YDL239C
subclass of: SO_0000673
so part of: YDL239C
location: complement(26403..28775)
location: region:26403-28775:-1
so has part: feature:26403-28775:-1:exon

NP_010042.2
type: Protein
SIO_000068: ncbiprotein

S000002398
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26403-28775:-1:exon

YDL238C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GUD1
locus tag: YDL238C
so part of: sequence
location: complement(<28985..>30454)
location: region:28985-30454:-1
so has part: feature:28985-30454:-1:exon
subclass of: SO_0000010

851360
type: Gene
SIO_000068: ncbigene

position:28985:-1
position: 28985
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:30454:-1
position: 30454
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:28985-30454:-1:exon

YDL238C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GUD1
locus tag: YDL238C
product: guanine deaminase
transcript id: NM_001180298.1
SIO_010081: YDL238C
subclass of: SO_0000673
so part of: YDL238C
location: complement(<28985..>30454)
location: region:28985-30454:-1
so has part: feature:28985-30454:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:28985-30454:-1:exon

YDL238C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GUD1
locus tag: YDL238C
EC number: 3.5.4.3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006147 guanine catabolic process [PMID:10542258]
experiment: EXISTENCE:direct assay:GO:0008892 guanine deaminase activity [PMID:15565584]
note: Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
codon start: 1
product: guanine deaminase
translation: MTKSDLLFDKFNDKHGKFLVFFGTFVDTPKLGELRIREKTSVGVLNGIIRFVNRNSLDPVKDCLDHDSSLSPEDVTVVDIIGKDKTRNNSFYFPGFVDTHNHVSQYPNVGVFGNSTLLDWLEKYTFPIEAALANENIAREVYNKVISKTLSHGTTTVAYYNTIDLKSTKLLAQLSSLLGQRVLVGKVCMDTNGPEYYIEDTKTSFESTVKVVKYIRETICDPLVNPIVTPRFAPSCSRELMQQLSKLVKDENIHVQTHLSENKEEIQWVQDLFPECESYTDVYDKYGLLTEKTVLAHCIHLTDAEARVIKQRRCGISHCPISNSSLTSGECRVRWLLDQGIKVGLGTDVSAGHSCSILTTGRQAFAVSRHLAMRETDHAKLSVSECLFLATMGGAQVLRMDETLGTFDVGKQFDAQMIDTNAPGSNVDMFHWQLKEKDQMQEQEQEQGQDPYKNPPLLTNEDIIAKWFFNGDDRNTTKVWVAGQQVYQI
SIO_010081: YDL238C
subclass of: SO_0000673
so part of: YDL238C
location: complement(28985..30454)
location: region:28985-30454:-1
so has part: feature:28985-30454:-1:exon

NP_010043.1
type: Protein
SIO_000068: ncbiprotein

S000002397
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:28985-30454:-1:exon

YDL237W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM6
locus tag: YDL237W
so part of: sequence
location: <30657..>31829
location: region:30657-31829:1
so has part: feature:30657-31829:1:exon
subclass of: SO_0000010

851361
type: Gene
SIO_000068: ncbigene

position:30657:1
position: 30657
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31829:1
position: 31829
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:30657-31829:1:exon

YDL237W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM6
locus tag: YDL237W
product: Aim6p
transcript id: NM_001180297.2
SIO_010081: YDL237W
subclass of: SO_0000673
so part of: YDL237W
location: <30657..>31829
location: region:30657-31829:1
so has part: feature:30657-31829:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:30657-31829:1:exon

YDL237W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM6
locus tag: YDL237W
note: hypothetical protein; required for respiratory growth; YDL237W is not an essential gene
codon start: 1
product: Aim6p
translation: MLGLKGCLTILIGYVIAVCALFSSRGRNPSLTDWEKLKDQKISNIDNFGLTGQHLLEFFQENLPFLSFSEEKYRHKHVSLYYDVFKEYILRRASSKKCLPVDSAIAKLNKDVNPMPVHSHNDYWRKLPLFEGLAYGASSTEADVWNIDEKILAVGHNEAYLDPVELTLDKLYTGPLLEILDEVNCQDSDADRKNGVFFNSPETSLFFYIDFKSDDNELTYKLLMEQYFKSLIDSGYLTYYDMKKDEIIWRPVTVILTGNYPTSLDILDNGNDNGYFESSQRFAFLDAPLLSLEPKYSKLSVAATVSFSQLMKHCGSDHWKVSLRGRMDSNEISCAKSIIDGAHALKLKTRIWGAPTWPANLVETISRQIIHDLGSDLLNLDNLFMASSLI
SIO_010081: YDL237W
subclass of: SO_0000673
so part of: YDL237W
location: 30657..31829
location: region:30657-31829:1
so has part: feature:30657-31829:1:exon

NP_010044.2
type: Protein
SIO_000068: ncbiprotein

S000002396
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:30657-31829:1:exon

YDL236W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHO13
locus tag: YDL236W
so part of: sequence
location: <32296..>33234
location: region:32296-33234:1
so has part: feature:32296-33234:1:exon
subclass of: SO_0000010

851362
type: Gene
SIO_000068: ncbigene

position:32296:1
position: 32296
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:33234:1
position: 33234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:32296-33234:1:exon

YDL236W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHO13
locus tag: YDL236W
product: 4-nitrophenylphosphatase
transcript id: NM_001180296.1
SIO_010081: YDL236W
subclass of: SO_0000673
so part of: YDL236W
location: <32296..>33234
location: region:32296-33234:1
so has part: feature:32296-33234:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:32296-33234:1:exon

YDL236W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHO13
locus tag: YDL236W
EC number: 3.1.3.41
experiment: EXISTENCE:direct assay:GO:0004035 alkaline phosphatase activity [PMID:9561742]
experiment: EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:9561742]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008967 phosphoglycolate phosphatase activity [PMID:27294321]
experiment: EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:27294321]
experiment: EXISTENCE:direct assay:GO:0046838 phosphorylated carbohydrate dephosphorylation [PMID:27294321]
note: Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts
codon start: 1
product: 4-nitrophenylphosphatase
translation: MTAQQGVPIKITNKEIAQEFLDKYDTFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGIDVKEEQIFTSGYASAVYIRDFLKLQPGKDKVWVFGESGIGEELKLMGYESLGGADSRLDTPFDAAKSPFLVNGLDKDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDSTFPQKGYTFPGAGSMIESLAFSSNRRPSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGGTLLVLSGIETEERALKISHDYPRPKFYIDKLGDIYTLTNNEL
SIO_010081: YDL236W
subclass of: SO_0000673
so part of: YDL236W
location: 32296..33234
location: region:32296-33234:1
so has part: feature:32296-33234:1:exon

NP_010045.1
type: Protein
SIO_000068: ncbiprotein

S000002395
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:32296-33234:1:exon

YDL235C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPD1
locus tag: YDL235C
so part of: sequence
location: complement(<33415..>33918)
location: region:33415-33918:-1
so has part: feature:33415-33918:-1:exon
subclass of: SO_0000010

851363
type: Gene
SIO_000068: ncbigene

position:33415:-1
position: 33415
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:33918:-1
position: 33918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:33415-33918:-1:exon

YDL235C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPD1
locus tag: YDL235C
product: Ypd1p
transcript id: NM_001180295.1
SIO_010081: YDL235C
subclass of: SO_0000673
so part of: YDL235C
location: complement(<33415..>33918)
location: region:33415-33918:-1
so has part: feature:33415-33918:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:33415-33918:-1:exon

YDL235C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPD1
locus tag: YDL235C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14665464]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14665464]
experiment: EXISTENCE:direct assay:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]
experiment: EXISTENCE:direct assay:GO:0016772 transferase activity, transferring phosphorus-containing groups [PMID:8808622]
experiment: EXISTENCE:mutant phenotype:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]
experiment: EXISTENCE:physical interaction:GO:0043424 protein histidine kinase binding [PMID:8808622]
note: Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
codon start: 1
product: Ypd1p
translation: MSTIPSEIINWTILNEIISMDDDDSDFSKGLIIQFIDQAQTTFAQMQRQLDGEKNLTELDNLGHFLKGSSAALGLQRIAWVCERIQNLGRKMEHFFPNKTELVNTLSDKSIINGINIDEDDEEIKIQVDDKDENSIYLILIAKALNQSRLEFKLARIELSKYYNTNL
SIO_010081: YDL235C
subclass of: SO_0000673
so part of: YDL235C
location: complement(33415..33918)
location: region:33415-33918:-1
so has part: feature:33415-33918:-1:exon

NP_010046.1
type: Protein
SIO_000068: ncbiprotein

S000002394
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:33415-33918:-1:exon

YDL234C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GYP7
locus tag: YDL234C
so part of: sequence
location: complement(<34237..>36477)
location: region:34237-36477:-1
so has part: feature:34237-36477:-1:exon
subclass of: SO_0000010

851364
type: Gene
SIO_000068: ncbigene

position:34237:-1
position: 34237
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:36477:-1
position: 36477
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:34237-36477:-1:exon

YDL234C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GYP7
locus tag: YDL234C
product: GTPase-activating protein GYP7
transcript id: NM_001180294.1
SIO_010081: YDL234C
subclass of: SO_0000673
so part of: YDL234C
location: complement(<34237..>36477)
location: region:34237-36477:-1
so has part: feature:34237-36477:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:34237-36477:-1:exon

YDL234C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GYP7
locus tag: YDL234C
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10508155]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:35134079]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016192 vesicle-mediated transport [PMID:11118206]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:10508155]
experiment: EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:18809726]
note: GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; contains a PH-like domain
codon start: 1
product: GTPase-activating protein GYP7
translation: MSKILFCKSKVFLHPTSDARDNIAGFLLLTLEANKLSHQAILQYIPESGLSTLEISKLLKHEAKVGTCPTSTPFVIENSINFSNLVNTSLGQAFEISLSQIYCIQFRPPSPNGWYVGSLVIYPLTEQFTGFQPPVLFFHDQLCPSTTDKLKRLRKSMNPFDDSDELYWGGVDLRNKINELMELKKSNLEPEFWLVNPSLNDLRNFVSKDLLESYNNSKKDTTELATAGVKLNEKFQEWKWNVMSKIADVTTKSTNFIDSWLTNNSPIQKSQIDNEYLQKLLNNEKVKQIEQDYDSARVYLANWSLGVKQEAERYQKQNKLFDSYRNNIFNDLNLTDELSDTEINNALQRQFPLTEAKWNSLWDENDGRLRVTVNEVKDFIFHGGLENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENNSTSPESANDESDDADDGVRNPHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFLRDQSGIHEQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVWFKREFEMEDIMHIWENFWTFYYSSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNELNGKLDWNDLMVRAELLFKKFEKMMHVMERDLQNVSSSSSSSSTGVLPCQSERLTLLLSKKPIIRHEGQRSKNSVK
SIO_010081: YDL234C
subclass of: SO_0000673
so part of: YDL234C
location: complement(34237..36477)
location: region:34237-36477:-1
so has part: feature:34237-36477:-1:exon

NP_010047.1
type: Protein
SIO_000068: ncbiprotein

S000002393
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:34237-36477:-1:exon

YDL233W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MFG1
locus tag: YDL233W
so part of: sequence
location: <36797..>38173
location: region:36797-38173:1
so has part: feature:36797-38173:1:exon
subclass of: SO_0000010

851365
type: Gene
SIO_000068: ncbigene

position:36797:1
position: 36797
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:38173:1
position: 38173
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:36797-38173:1:exon

YDL233W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MFG1
locus tag: YDL233W
product: Mfg1p
transcript id: NM_001180293.1
SIO_010081: YDL233W
subclass of: SO_0000673
so part of: YDL233W
location: <36797..>38173
location: region:36797-38173:1
so has part: feature:36797-38173:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:36797-38173:1:exon

YDL233W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MFG1
locus tag: YDL233W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
codon start: 1
product: Mfg1p
translation: MYQGPPQPPPQAVPMPYIVNNNTPPYPNGNINFPPTAQQNIPPTVYPQQVPFPGQPQGGQFPQPSSEQQVFNQLPQVTQTFHNSAQNTNATGGPGSGSMPMFTPVASFPHPMATAATAAAPLPRSASQASLSMLRVPYHVRKYLSNLAMLKLYEIINEVNTAMGKIGLLSFWTELISDIFTPDAVIRYSKKSMTDYREFEFIIPVFPVICSTLGRFGIVRMEVKVLQLKTQVLSNSTIFFNCPRVTFVYYYPDGSYITHFSQMKGAFDLDLKINWLDVSMHSFVPDIEWNAVERLLSDDTKSTEIEQIFRKLKQEDVKEQGNSFAENNATNVPPNFEAITQLRSYFDVFRNVSVFGTQEGLMRVMQISTVMSTLKNLRKFQIEKNIDSPVTALSAYIDADKKDSGSEPLHAKRRRNSGISPRTTTLGPNGNSNTSNEELPTSDVNDINKDMTKKKMKF
SIO_010081: YDL233W
subclass of: SO_0000673
so part of: YDL233W
location: 36797..38173
location: region:36797-38173:1
so has part: feature:36797-38173:1:exon

NP_010048.1
type: Protein
SIO_000068: ncbiprotein

S000002392
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:36797-38173:1:exon

YDL232W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OST4
locus tag: YDL232W
so part of: sequence
location: <38487..>38597
location: region:38487-38597:1
so has part: feature:38487-38597:1:exon
subclass of: SO_0000010

851366
type: Gene
SIO_000068: ncbigene

position:38487:1
position: 38487
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:38597:1
position: 38597
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:38487-38597:1:exon

YDL232W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OST4
locus tag: YDL232W
product: olichyl-diphosphooligosaccharide--protein glycotransferase OST4
transcript id: NM_001180292.1
SIO_010081: YDL232W
subclass of: SO_0000673
so part of: YDL232W
location: <38487..>38597
location: region:38487-38597:1
so has part: feature:38487-38597:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:38487-38597:1:exon

YDL232W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OST4
locus tag: YDL232W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12810948]
experiment: EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:10677492]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex
codon start: 1
product: olichyl-diphosphooligosaccharide--protein glycotransferase OST4
translation: MISDEQLNSLAITFGIVMMTLIVIYHAVDSTMSPKN
SIO_010081: YDL232W
subclass of: SO_0000673
so part of: YDL232W
location: 38487..38597
location: region:38487-38597:1
so has part: feature:38487-38597:1:exon

NP_010049.1
type: Protein
SIO_000068: ncbiprotein

S000002391
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:38487-38597:1:exon

YDL231C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BRE4
locus tag: YDL231C
so part of: sequence
location: complement(<38867..>42244)
location: region:38867-42244:-1
so has part: feature:38867-42244:-1:exon
subclass of: SO_0000010

851367
type: Gene
SIO_000068: ncbigene

position:38867:-1
position: 38867
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:42244:-1
position: 42244
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:38867-42244:-1:exon

YDL231C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BRE4
locus tag: YDL231C
product: Bre4p
transcript id: NM_001180291.1
SIO_010081: YDL231C
subclass of: SO_0000673
so part of: YDL231C
location: complement(<38867..>42244)
location: region:38867-42244:-1
so has part: feature:38867-42244:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:38867-42244:-1:exon

YDL231C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BRE4
locus tag: YDL231C
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]
note: Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
codon start: 1
product: Bre4p
translation: MKRYERDRSPTPDPDIVKGSYSQTSLRSLHELNYKNPAGISGLSFAGSPQQSVASLSQMRLENLVKDKHWEEVEDFGLEELRDGFFDAAFTKPDSKARSPNSDIDDDNGAARKKLQSGFTKLSEYVWTAIYRPIIHFPRDIRKNGVSIFKFFIAYFIAIVICVIRPSGRWIGHEFRYFLPIAVLIHHPVRNIGVQLEMTISSIIGASFGLGWSALAWYISTATKPTANYQGGILFQSLTMALLFAIWLRSVYRRFFYFTTSFSISIIFTHTVRLASSKFDLKWQIFWDFGISYLFGLLLSLLVCVCVSPHSGNAELMEHYNKCLQTTKTFLMALVDTELIKSKEQIYLAQVKMVKTLNIDLSQGFRDFVNQLTISRFDLQSLKSLRNSLTAMETSLRVLPIAPKIFNDDELKKMYEELEKYRSDSATLSKEASASPQSSGIPTRENTPSAFKPIGPGLLKNEIYINALKASFSKSIFNLILEMIFVLENLSRVLKKYESPNQKNNLDECVKILSHSHSKLKRKIYKLDVCYRDFVNSSFFSQELLNDEESVDIFLFLRYLRNSARQLVTVIHDCQVLGENIHWRIALPSYPLSRALTRLPKQCVLDEGAGNVLHYFEAKRDVDEIFERVYNTYTSRHKYNKGEEEALRLDSQGGDEKSQNRKNHTISIRAIDHNDFNFHTTQNPWRFKLWKLSRILSGDECKWTLKITFCMIFLCLPTWLPESYHWYQEFHCWWAPLTFYLLAHRRYSGNWALVMRRLICGIVGIFWGWAANQSRHFGSPYVVCTFAGLIVVPFSINFLVYRNTKSSFTALMCFTIIALEPYSKPNRHYNLTTAGIWKSTWVTGLALIIGILVSIPINWIVWPFRARTELRDSMSSLLAHLGQSYQTVADRYLYRDADDAPTDLTFAFSHIREVRLTQSLEAIRELLKKARHEPIIISNFNPEKYASLINSCQFLLSKIIEARISGAFFEIWDQDFDIETTRALLSLRRDSVSSVIFVFYILSNCFRSKNKIPRYLPNPIMSRKKLYHFIKKFSEMKDQSHSNLNSGGNSMEKNLFKKIYQQKASSSGQQQLPLPSVANSSEIDSEKMHWTEVHGIAFARAFTDISEALFQVESCAKDILGEENF
SIO_010081: YDL231C
subclass of: SO_0000673
so part of: YDL231C
location: complement(38867..42244)
location: region:38867-42244:-1
so has part: feature:38867-42244:-1:exon

NP_010050.1
type: Protein
SIO_000068: ncbiprotein

S000002390
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:38867-42244:-1:exon

YDL230W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTP1
locus tag: YDL230W
so part of: sequence
location: <42700..>43707
location: region:42700-43707:1
so has part: feature:42700-43707:1:exon
subclass of: SO_0000010

851368
type: Gene
SIO_000068: ncbigene

position:42700:1
position: 42700
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:43707:1
position: 43707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:42700-43707:1:exon

YDL230W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTP1
locus tag: YDL230W
product: tyrosine protein phosphatase PTP1
transcript id: NM_001180290.1
SIO_010081: YDL230W
subclass of: SO_0000673
so part of: YDL230W
location: <42700..>43707
location: region:42700-43707:1
so has part: feature:42700-43707:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:42700-43707:1:exon

YDL230W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTP1
locus tag: YDL230W
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:1649172]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:21460040]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:21460040]
note: Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
codon start: 1
product: tyrosine protein phosphatase PTP1
translation: MAAAPWYIRQRDTDLLGKFKFIQNQEDGRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRHSDRATEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLNSLSVNQ
SIO_010081: YDL230W
subclass of: SO_0000673
so part of: YDL230W
location: 42700..43707
location: region:42700-43707:1
so has part: feature:42700-43707:1:exon

NP_010051.1
type: Protein
SIO_000068: ncbiprotein

S000002389
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:42700-43707:1:exon

YDL229W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YG101
gene: SSB1
locus tag: YDL229W
gene synonym: YG101
so part of: sequence
location: <44065..>45906
location: region:44065-45906:1
so has part: feature:44065-45906:1:exon
subclass of: SO_0000010

851369
type: Gene
SIO_000068: ncbigene

position:44065:1
position: 44065
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45906:1
position: 45906
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:44065-45906:1:exon

YDL229W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YG101
gene: SSB1
locus tag: YDL229W
gene synonym: YG101
product: Hsp70 family ATPase SSB1
transcript id: NM_001180289.1
SIO_010081: YDL229W
subclass of: SO_0000673
so part of: YDL229W
location: <44065..>45906
location: region:44065-45906:1
so has part: feature:44065-45906:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:44065-45906:1:exon

YDL229W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YG101
gene: SSB1
locus tag: YDL229W
gene synonym: YG101
EC number: 3.6.4.10
experiment: EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17146552]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19502427]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:1394434|PMID:16413483]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9860955]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9670014]
experiment: EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:9670014]
experiment: EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:20368619]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:20368619]
experiment: EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:19723765]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1394434]
experiment: EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:17483428]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]
experiment: EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]
experiment: EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:1394434]
note: Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
codon start: 1
product: Hsp70 family ATPase SSB1
translation: MAEGVFQGAIGIDLGTTYSCVATYESSVEIIANEQGNRVTPSFVAFTPEERLIGDAAKNQAALNPRNTVFDAKRLIGRRFDDESVQKDMKTWPFKVIDVDGNPVIEVQYLEETKTFSPQEISAMVLTKMKEIAEAKIGKKVEKAVITVPAYFNDAQRQATKDAGAISGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLHIAGGVYTVKSTSGNTHLGGQDFDTNLLEHFKAEFKKKTGLDISDDARALRRLRTAAERAKRTLSSVTQTTVEVDSLFDGEDFESSLTRARFEDLNAALFKSTLEPVEQVLKDAKISKSQIDEVVLVGGSTRIPKVQKLLSDFFDGKQLEKSINPDEAVAYGAAVQGAILTGQSTSDETKDLLLLDVAPLSLGVGMQGDMFGIVVPRNTTVPTIKRRTFTTCADNQTTVQFPVYQGERVNCKENTLLGEFDLKNIPMMPAGEPVLEAIFEVDANGILKVTAVEKSTGKSSNITISNAVGRLSSEEIEKMVNQAEEFKAADEAFAKKHEARQRLESYVASIEQTVTDPVLSSKLKRGSKSKIEAALSDALAALQIEDPSADELRKAEVGLKRVVTKAMSSR
SIO_010081: YDL229W
subclass of: SO_0000673
so part of: YDL229W
location: 44065..45906
location: region:44065-45906:1
so has part: feature:44065-45906:1:exon

NP_010052.1
type: Protein
SIO_000068: ncbiprotein

S000002388
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:44065-45906:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS404; Autonomously Replicating Sequence
so part of: sequence
location: 46185..46237
location: region:46185-46237:1
so has part: feature:46185-46237:1:region

S000114787
type: SGD
SIO_000068: sgd

position:46185:1
position: 46185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:46237:1
position: 46237
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:46185-46237:1:region

YDL227C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HO
locus tag: YDL227C
so part of: sequence
location: complement(<46271..>48031)
location: region:46271-48031:-1
so has part: feature:46271-48031:-1:exon
subclass of: SO_0000010

851371
type: Gene
SIO_000068: ncbigene

position:46271:-1
position: 46271
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48031:-1
position: 48031
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:46271-48031:-1:exon

YDL227C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HO
locus tag: YDL227C
product: Hop
transcript id: NM_001180287.1
SIO_010081: YDL227C
subclass of: SO_0000673
so part of: YDL227C
location: complement(<46271..>48031)
location: region:46271-48031:-1
so has part: feature:46271-48031:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:46271-48031:-1:exon

YDL227C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HO
locus tag: YDL227C
experiment: EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:6313222|PMID:6099261]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0007534 gene conversion at mating-type locus [PMID:6313222]
experiment: EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:6297747]
note: Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p
codon start: 1
product: Hop
translation: MLSENTTILMANGEIKDIANVTANSYVMCADGSAARVINVTQGYQKIYNIQQKTKHRAFEGEPGRLDPRRRTVYQRLALQCTAGHKLSVRVPTKPLLEKSGRNATKYKVRWRNLQQCQTLDGRIIIIPKNHHKTFPMTVEGEFAAKRFIEEMERSKGEYFNFDIEVRDLDYLDAQLRISSCIRFGPVLAGNGVLSKFLTGRSDLVTPAVKSMAWMLGLWLGDSTTKEPEISVDSLDPKLMESLRENAKIWGLYLTVCDDHVPLRAKHVRLHYGDGPDENRKTRNLRKNNPFWKAVTILKFKRDLDGEKQIPEFMYGEHIEVREAFLAGLIDSDGYVVKKGEGPESYKIAIQTVYSSIMDGIVHISRSLGMSATVTTRSAREEIIEGRKVQCQFTYDCNVAGGTTSQNVLSYCRSGHKTREVPPIIKREPVYFSFTDDFQGESTVYGLTIEGHKNFLLGNKIEVKSCRGCCVGEQLKISQKKNLKHCVACPRKGIKYFYKDWSGKNRVCARCYGRYKFSGHHCINCKYVPEAREVKKAKDKGEKLGITPEGLPVKGPECIKCGGILQFDAVRGPHKSCGNNAGARIC
SIO_010081: YDL227C
subclass of: SO_0000673
so part of: YDL227C
location: complement(46271..48031)
location: region:46271-48031:-1
so has part: feature:46271-48031:-1:exon

NP_010054.1
type: Protein
SIO_000068: ncbiprotein

S000002386
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:46271-48031:-1:exon

YDL226C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GCS1
locus tag: YDL226C
so part of: sequence
location: complement(<51115..>52173)
location: region:51115-52173:-1
so has part: feature:51115-52173:-1:exon
subclass of: SO_0000010

851372
type: Gene
SIO_000068: ncbigene

position:51115:-1
position: 51115
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:52173:-1
position: 52173
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:51115-52173:-1:exon

YDL226C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GCS1
locus tag: YDL226C
product: GTPase-activating protein GCS1
transcript id: NM_001180286.1
SIO_010081: YDL226C
subclass of: SO_0000673
so part of: YDL226C
location: complement(<51115..>52173)
location: region:51115-52173:-1
so has part: feature:51115-52173:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:51115-52173:-1:exon

YDL226C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GCS1
locus tag: YDL226C
experiment: EXISTENCE:direct assay:GO:0003779 actin binding [PMID:10069805]
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:15975906|PMID:8816753]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:16452633]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16452633]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]
experiment: EXISTENCE:mutant phenotype:GO:0005856 cytoskeleton [PMID:10069805]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9927415]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]
experiment: EXISTENCE:mutant phenotype:GO:0030037 actin filament reorganization involved in cell cycle [PMID:10069805]
experiment: EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]
note: ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication
codon start: 1
product: GTPase-activating protein GCS1
translation: MSDWKVDPDTRRRLLQLQKIGANKKCMDCGAPNPQWATPKFGAFICLECAGIHRGLGVHISFVRSITMDQFKPEELLRMEKGGNEPLTEWFKSHNIDLSLPQKVKYDNPVAEDYKEKLTCLCEDRVFEEREHLDFDASKLSATSQTAASATPGVAQSREGTPLENRRSATPANSSNGANFQKEKNEAYFAELGKKNQSRPDHLPPSQGGKYQGFGSTPAKPPQERSAGSSNTLSLENFQADPLGTLSRGWGLFSSAVTKSFEDVNETVIKPHVQQWQSGELSEETKRAAAQFGQKFQETSSYGFQAFSNFTKNFNGNAEDSSTAGNTTHTEYQKIDNNDKKNEQDEDKWDDF
SIO_010081: YDL226C
subclass of: SO_0000673
so part of: YDL226C
location: complement(51115..52173)
location: region:51115-52173:-1
so has part: feature:51115-52173:-1:exon

NP_010055.1
type: Protein
SIO_000068: ncbiprotein

S000002385
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:51115-52173:-1:exon

YDL225W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEP7
gene: SHS1
locus tag: YDL225W
gene synonym: SEP7
so part of: sequence
location: <52445..>54100
location: region:52445-54100:1
so has part: feature:52445-54100:1:exon
subclass of: SO_0000010

851373
type: Gene
SIO_000068: ncbigene

position:52445:1
position: 52445
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:54100:1
position: 54100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:52445-54100:1:exon

YDL225W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEP7
gene: SHS1
locus tag: YDL225W
gene synonym: SEP7
product: septin SHS1
transcript id: NM_001180285.1
SIO_010081: YDL225W
subclass of: SO_0000673
so part of: YDL225W
location: <52445..>54100
location: region:52445-54100:1
so has part: feature:52445-54100:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:52445-54100:1:exon

YDL225W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEP7
gene: SHS1
locus tag: YDL225W
gene synonym: SEP7
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:17603111]
experiment: EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:22144691|PMID:29321251]
experiment: EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14597621]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0061163 endoplasmic reticulum polarization [PMID:25083872]
experiment: EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18431499]
experiment: EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:17603111]
experiment: EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:25971666]
experiment: EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:17603111]
experiment: EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:22144691]
experiment: EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:12699621]
experiment: EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:12636916]
experiment: EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:17603111]
experiment: EXISTENCE:physical interaction:GO:0005935 cellular bud neck [PMID:25083872]
note: Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
codon start: 1
product: septin SHS1
translation: MSTASTPPINLFRRKKEHKRGITYTMLLCGPAGTGKTAFANNLLETKIFPHKYQYGKSNASISSNPEVKVIAPTKVVSFNSKNGIPSYVSEFDPMRANLEPGITITSTSLELGGNKDQGKPEMNEDDTVFFNLIMTHGIGENLDDSLCSEEVMSYLEQQFDIVLAEETRIKRNPRFEDTRVHVALYFIEPTGHGLREVDVELMKSISKYTNVLPIITRADSFTKEELTQFRKNIMFDVERYNVPIYKFEVDPEDDDLESMEENQALASLQPFAIITSDTRDSEGRYVREYPWGIISIDDDKISDLKVLKNVLFGSHLQEFKDTTQNLLYENYRSEKLSSVANAEEIGPNSTKRQSNAPSLSNFASLISTGQFNSSQTLANNLRADTPRNQVSGNFKENEYEDNGEHDSAENEQEMSPVRQLGREIKQENENLIRSIKTESSPKFLNSPDLPERTKLRNISETVPYVLRHERILARQQKLEELEAQSAKELQKRIQELERKAHELKLREKLINQNKLNGSSSSINSLQQSTRSQIKKNDTYTDLASIASGRD
SIO_010081: YDL225W
subclass of: SO_0000673
so part of: YDL225W
location: 52445..54100
location: region:52445-54100:1
so has part: feature:52445-54100:1:exon

NP_010056.1
type: Protein
SIO_000068: ncbiprotein

S000002384
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:52445-54100:1:exon

YDL224C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WHI4
locus tag: YDL224C
so part of: sequence
location: complement(<54397..>56346)
location: region:54397-56346:-1
so has part: feature:54397-56346:-1:exon
subclass of: SO_0000010

851302
type: Gene
SIO_000068: ncbigene

position:54397:-1
position: 54397
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:56346:-1
position: 56346
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:54397-56346:-1:exon

YDL224C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WHI4
locus tag: YDL224C
product: Whi4p
transcript id: NM_001180284.1
SIO_010081: YDL224C
subclass of: SO_0000673
so part of: YDL224C
location: complement(<54397..>56346)
location: region:54397-56346:-1
so has part: feature:54397-56346:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:54397-56346:-1:exon

YDL224C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WHI4
locus tag: YDL224C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0008361 regulation of cell size [PMID:11290704]
experiment: EXISTENCE:genetic interaction:GO:0061157 mRNA destabilization [PMID:24386402]
note: Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
codon start: 1
product: Whi4p
translation: MSLVHNQTNLNESKFLIERAFSSSSETVPLSKEATYPMPTAYSFSAVRSNSETNIKRENPQGFAKEPIMTSMLHNLTMSTGKGNGNDVNSLAPHDVDVGPYCLLLRNLPKDITLRECYCIFSLATGVSSIELKRDDREPFNDNEKVVVVKFGSLSLVTHYANILNSKSEIFGPSFPFRSHIDVVNEQTQLPVSFQEHVSSGTTNSSPKNYQLSSSAQNEIQNQSFNTISYGKTSSSPLGPSAAKPRPSLLSERSLRFSFNDPFGLETISQRKESVPFLRNSISQHDLSNVTTTPVPAGMPPQKDAGKSLLLLEKDEINESIWNGDELVNDVGNSSFGASLQEPPMSSTPVMEWNASSTANIPLFQLSSQENHQSNLLPPSHHSISQDVPHIQSQPNLNNSGVIHSATSLPHYHLLNQINASTKTQSIQQSVSNVPSNLDLNLQTENGHPQSSAPNGSSIFNNQKVNQGFLVSEQDTSTISRQKECSSTASASAFSKNNETNVAGSTTISQADLSLLAKVPPPANPADQNPPCNTLYVGNLPPDATEQELRQLFSNQQGFRRLSFRNKMNSHGHGNGHGHGPICFVEFEDVSFATRALAELYGSQLPHPRPSLNNKGGIRLSFSKNPLGVRGSNSRSKSGYSFNGSYGKS
SIO_010081: YDL224C
subclass of: SO_0000673
so part of: YDL224C
location: complement(54397..56346)
location: region:54397-56346:-1
so has part: feature:54397-56346:-1:exon

NP_010057.1
type: Protein
SIO_000068: ncbiprotein

S000002383
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:54397-56346:-1:exon

YDL223C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HBT1
locus tag: YDL223C
so part of: sequence
location: complement(<57265..>60405)
location: region:57265-60405:-1
so has part: feature:57265-60405:-1:exon
subclass of: SO_0000010

851303
type: Gene
SIO_000068: ncbigene

position:57265:-1
position: 57265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:60405:-1
position: 60405
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:57265-60405:-1:exon

YDL223C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HBT1
locus tag: YDL223C
product: Hbt1p
transcript id: NM_001180283.1
SIO_010081: YDL223C
subclass of: SO_0000673
so part of: YDL223C
location: complement(<57265..>60405)
location: region:57265-60405:-1
so has part: feature:57265-60405:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:57265-60405:-1:exon

YDL223C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HBT1
locus tag: YDL223C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005937 mating projection [PMID:11923536]
experiment: EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:11923536]
note: Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication
codon start: 1
product: Hbt1p
translation: MNMNESISKDGQGEEEQNNFSFGGKPGSYDSNSDSAQRKKSFSTTKPTEYNLPKEQPESTSKNLETKAKNILLPWRKKHNKDSETPHEDTEADANRRANVTSDVNPVSADTKSSSGPNATITTHGYSYVKTTTPAATSEQSKVKTSPPTSHEHSNIKASPTAHRHSKGDAGHPSIATTHNHSTSKAATSPVTHTHGHSSATTSPVTHTHGHASVKTTSPTNTHEHSKANTGPSATATTHGHINVKTTHPVSHGHSGSSTGPKSTAAAQDHSSTKTNPSVTHGHTSVKDNSSATKGYSNTDSNSDRDVIPGSFRGMTGTDVNPVDPSVYTSTGPKSNVSSGMNAVDPSVYTDTSSKSADRRKYSGNTATGPPQDTIKEIAQNVKMDESEQTGLKNDQVSGSDAIQQQTMEPEPKAAVGTSGFVSQQPSYHDSNKNIQHPEKNKVDNKNISERAAEKFNIERDDILESADDYQQKNIKSKTDSNWGPIEYSSSAGKNKNLQDVVIPSSMKEKFDSGTSGSQNMPKAGTELGHMKYNDNGRDNLQYVAGSQAGSQNTNNNIDMSPRHEAEWSGLSNDATTRNNVVSPAMKDEDMNEDSTKPHQYGLDYLDDVEDYHENDIDDYSNAKKNDLYSKKAYQGKPSDYNYEQREKIPGTFEPDTLSKSVQKQDEDPLSPRQTTNRAGMETARDESLGNYEYSNTSGNKKLSDLSKNKSGPTPTRSNFIDQIEPRRAKTTQDIASDAKDFTNNPETGTTGNVDTTGRMGAKSKTFSSNPFDDSKNTDTHLENANVAAFDNSRSGDTTYSKSGDAETAAYDNIKNADPTYAKSQDITGMTHDQEPSSEQKASYGSGGNSQNQEYSSDDNIDVNKNAKVLEEDAPGYKREVDLKNKRRTDLGGADASNAYAAEVGNFPSLIDPHVPTYGFKDTNTSSSQKPSEGTYPETTSYSIHNETTSQGRKVSVGSMGSGKSKHHHNHHRHSRQNSSKGSDYDYNNSTHSAEHTPRHHQYGSDEGEQDYHDDEQGEEQAGKQSFMGRVRKSISGGTFGFRSEI
SIO_010081: YDL223C
subclass of: SO_0000673
so part of: YDL223C
location: complement(57265..60405)
location: region:57265-60405:-1
so has part: feature:57265-60405:-1:exon

NP_010058.1
type: Protein
SIO_000068: ncbiprotein

S000002382
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:57265-60405:-1:exon

YDL222C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP45
locus tag: YDL222C
so part of: sequence
location: complement(<60872..>61801)
location: region:60872-61801:-1
so has part: feature:60872-61801:-1:exon
subclass of: SO_0000010

851304
type: Gene
SIO_000068: ncbigene

position:60872:-1
position: 60872
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:61801:-1
position: 61801
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:60872-61801:-1:exon

YDL222C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP45
locus tag: YDL222C
product: Fmp45p
transcript id: NM_001180282.1
SIO_010081: YDL222C
subclass of: SO_0000673
so part of: YDL222C
location: complement(<60872..>61801)
location: region:60872-61801:-1
so has part: feature:60872-61801:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:60872-61801:-1:exon

YDL222C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP45
locus tag: YDL222C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11784867]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:11784867]
note: Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication
codon start: 1
product: Fmp45p
translation: MIFKRFVNLLVFLFLLGAGLLTFFLILSGGRESGTLKNFYWLQADTNGFNSAPSTTRWYNYNWCGYEDGQLANCSSRAPAKPFSPRDNFGNSVNLPSSFRNNRDTYYYLSRVGWAMLLISLFFIVLALVPGFLATFLPFKAVPVLYCVLSWLAFFFIILAACLYTGCYVKARKTFRNSGRSARLGPKNFAFIWTSVFLMLVNAIWSTIFSATHKAHSTYSDHDMYAQYESPSVDTGAQMEKSTYNSGATDGAGPITAAPVVGQPQPTTTTTPAGNGKFFQKLKTRKQVPSAELEPAGDGGLAGPVTVRD
SIO_010081: YDL222C
subclass of: SO_0000673
so part of: YDL222C
location: complement(60872..61801)
location: region:60872-61801:-1
so has part: feature:60872-61801:-1:exon

NP_010059.1
type: Protein
SIO_000068: ncbiprotein

S000002381
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:60872-61801:-1:exon

YDL220C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EST4
gene: CDC13
locus tag: YDL220C
gene synonym: EST4
so part of: sequence
location: complement(<62244..>65018)
location: region:62244-65018:-1
so has part: feature:62244-65018:-1:exon
subclass of: SO_0000010

851306
type: Gene
SIO_000068: ncbigene

position:62244:-1
position: 62244
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:65018:-1
position: 65018
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62244-65018:-1:exon

YDL220C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EST4
gene: CDC13
locus tag: YDL220C
gene synonym: EST4
product: telomere-binding protein CDC13
transcript id: NM_001180280.1
SIO_010081: YDL220C
subclass of: SO_0000673
so part of: YDL220C
location: complement(<62244..>65018)
location: region:62244-65018:-1
so has part: feature:62244-65018:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:62244-65018:-1:exon

YDL220C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EST4
gene: CDC13
locus tag: YDL220C
gene synonym: EST4
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9710643]
experiment: EXISTENCE:direct assay:GO:0010521 telomerase inhibitor activity [PMID:19043074]
experiment: EXISTENCE:direct assay:GO:0032210 regulation of telomere maintenance via telomerase [PMID:27659693]
experiment: EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17166094|PMID:8824190|PMID:8943008]
experiment: EXISTENCE:direct assay:GO:0051974 negative regulation of telomerase activity [PMID:19043074]
experiment: EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:31006804]
experiment: EXISTENCE:genetic interaction:GO:0007004 telomere maintenance via telomerase [PMID:11239396]
experiment: EXISTENCE:genetic interaction:GO:0032210 regulation of telomere maintenance via telomerase [PMID:11046137]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11390652]
experiment: EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:8978029]
experiment: EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:7565765]
experiment: EXISTENCE:mutant phenotype:GO:0043047 single-stranded telomeric DNA binding [PMID:17166094]
experiment: EXISTENCE:mutant phenotype:GO:0071166 ribonucleoprotein complex localization [PMID:25387524]
experiment: EXISTENCE:physical interaction:GO:1990879 CST complex [PMID:11230140]
note: Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle
codon start: 1
product: telomere-binding protein CDC13
translation: MDTLEEPECPPHKNRIFVSSSKDFEGYPSKAIVPVQFVALLTSIHLTETKCLLGFSNFERRGDQSQEDQYLIKLKFKDRGSERLARITISLLCQYFDIELPDLDSDSGASPTVILRDIHLERLCFSSCKALYVSKHGNYTLFLEDIKPLDLVSVISTISTKSTNSSKHSSSELISECDLNNSLVDIFNNLIEMNRDEKNRFKFVKLIHYDIELKKFVQDQQKVLSQKSKAAAINPFFVPNRLGIPYIESQNEFNSQLMTLNVDEPTTDISNMGEEMHDSADPIEDSDSSTTSSTGKYFSSKSYIQSQTPERKTSVPNNWHDDDSGSKRKRKLSFHSPNASSIRKAISYEQLSLASVGSVERLEGKIVGMNPPQFASINEFKYCTLKLYFTQLLPNVPDKVLVPGVNCIEIVIPTRERICELFGVLNCQSDKISDILLLEKPDRISVEVERILWDNDKTASPGMAVWSLKNISTDTQAQAQVQVPAQSSASIDPSRTRMSKMARKDPTIEFCQLGLDTFETKYITMFGMLVSCSFDKPAFISFVFSDFTKNDIVQNYLYDRYLIDYENKLELNEGFKAIMYKNQFETFDSKLRKIFNNGLRDLQNGRDENLSQYGIVCKMNIKVKMYNGKLNAIVRECEPVPHSQISSIASPSQCEHLRLFYQRAFKRIGESAISRYFEEYRRFFPIHRNGSHLAKLRFDEVKHEPKKSPTTPALAEHIPDLNADVSSFDVKFTDISSLLDSSARLPRPQQTHKSNTLYSCEGRIIAIEYHASDLCFHITNELPLLQTRGLAPERVLQLHIITSKNFAYFFNRSSAYLQRQPLEEKYTQLAQFLGHSFKFNITSSLTLFPDTTVALQIWCPIECTFRELQQQLAHPKVAAAPDSGSLDCAINATVNPLRLLAAQNGVTVKKEEDNDDDAGAVPTS
SIO_010081: YDL220C
subclass of: SO_0000673
so part of: YDL220C
location: complement(62244..65018)
location: region:62244-65018:-1
so has part: feature:62244-65018:-1:exon

NP_010061.1
type: Protein
SIO_000068: ncbiprotein

S000002379
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:62244-65018:-1:exon

YDL219W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DTD1
locus tag: YDL219W
so part of: sequence
location: <65242..>65765
location: region:65242-65765:1
so has part: feature:65242-65765:1:exon
subclass of: SO_0000010

851307
type: Gene
SIO_000068: ncbigene

position:65242:1
position: 65242
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:65765:1
position: 65765
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:65242-65765:1:exon

YDL219W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DTD1
locus tag: YDL219W
product: D-tyrosyl-tRNA(Tyr) deacylase
transcript id: NM_001180279.1
SIO_010081: YDL219W
subclass of: SO_0000673
so part of: YDL219W
location: join(<65242..65306,65378..>65765)
location: region:65242-65765:1
so has part: feature:65242-65306:1:exon
so has part: feature:65378-65765:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:65242-65306:1:exon

position:65306:1
position: 65306
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:65378-65765:1:exon

position:65378:1
position: 65378
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL219W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DTD1
locus tag: YDL219W
EC number: 3.1.1.96
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006399 tRNA metabolic process [PMID:10918062]
experiment: EXISTENCE:mutant phenotype:GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity [PMID:10766779]
experiment: EXISTENCE:mutant phenotype:GO:0097358 D-leucyl-tRNA(Leu) deacylase activity [PMID:10918062]
experiment: EXISTENCE:mutant phenotype:GO:1900829 D-tyrosine catabolic process [PMID:10918062]
experiment: EXISTENCE:mutant phenotype:GO:1900832 D-leucine catabolic process [PMID:10918062]
note: D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
codon start: 1
product: D-tyrosyl-tRNA(Tyr) deacylase
translation: MKIVLQKVSQASVVVDSKVISSIKHGYMLLVGISIDDSMAEIDKLSKKVLSLRIFEDESRNLWKKNIKEANGEILSVSQFTLMAKTKKGTKPDFHLAQKGHIAKELYEEFLKLLRSDLGEEKVKDGEFGAMMSCSLTNEGPVTIILDSDQ
SIO_010081: YDL219W
subclass of: SO_0000673
so part of: YDL219W
location: join(65242..65306,65378..65765)
location: region:65242-65765:1
so has part: feature:65242-65306:1:exon
so has part: feature:65378-65765:1:exon

NP_010062.1
type: Protein
SIO_000068: ncbiprotein

S000002378
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:65242-65306:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:65378-65765:1:exon

YDL218W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL218W
so part of: sequence
location: <66493..>67446
location: region:66493-67446:1
so has part: feature:66493-67446:1:exon
subclass of: SO_0000010

851308
type: Gene
SIO_000068: ncbigene

position:66493:1
position: 66493
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:67446:1
position: 67446
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:66493-67446:1:exon

YDL218W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL218W
product: uncharacterized protein
transcript id: NM_001180278.1
SIO_010081: YDL218W
subclass of: SO_0000673
so part of: YDL218W
location: <66493..>67446
location: region:66493-67446:1
so has part: feature:66493-67446:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:66493-67446:1:exon

YDL218W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL218W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
note: hypothetical protein; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
codon start: 1
product: uncharacterized protein
translation: MKRVTGVFLTLLRFSQFASSVLVMSLLAYAIHAYGNRGNKKTNFTLATGVISVFYLIALGILCLALPTLIYIGMYFCAELIVCMLWLAAFVVLAKAQGERSCSNTNADGLYYNPYSGQYTADSHRRACNSSQAAIAFSGLCFVLFLISVILLGINVLTPIRKRYQTQGMWRSGASMGTKLHRWSGLALSEPFEETAAYDNTNVRTGDVEAGAGDNAAYTSEPNGDARYATNDPNGQYHTTTTNTRYTTTTADPKTRYTTNDRNPGSANVANSAVDQHAYSTDESGDRSYQEKVTEGAHSGAMSGSTAEPNRNVNQMP
SIO_010081: YDL218W
subclass of: SO_0000673
so part of: YDL218W
location: 66493..67446
location: region:66493-67446:1
so has part: feature:66493-67446:1:exon

NP_010063.1
type: Protein
SIO_000068: ncbiprotein

S000002377
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:66493-67446:1:exon

YDL217C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIM22
locus tag: YDL217C
so part of: sequence
location: complement(<67983..>68606)
location: region:67983-68606:-1
so has part: feature:67983-68606:-1:exon
subclass of: SO_0000010

851309
type: Gene
SIO_000068: ncbigene

position:67983:-1
position: 67983
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:68606:-1
position: 68606
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:67983-68606:-1:exon

YDL217C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIM22
locus tag: YDL217C
product: translocation channel protein TIM22
transcript id: NM_001180277.1
SIO_010081: YDL217C
subclass of: SO_0000673
so part of: YDL217C
location: complement(<67983..>68606)
location: region:67983-68606:-1
so has part: feature:67983-68606:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:67983-68606:-1:exon

YDL217C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIM22
locus tag: YDL217C
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:32591483]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:32591483]
experiment: EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:11864609]
experiment: EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:11864609]
experiment: EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:10648604|PMID:10637294]
experiment: EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:32591483]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:32591483]
experiment: EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:8955274|PMID:32591483|PMID:10648604]
note: Essential core component of mitochondrial TIM22 complex; involved in insertion of polytopic proteins into inner membrane; forms channel through which proteins are imported; different regions of Tim22p have functionally diverse roles in recruiting partner subunits to core channel
codon start: 1
product: translocation channel protein TIM22
translation: MVYTGFGLEQISPAQKKPYNELTPEEQGERGAEMIMNFMTSCPGKSVVSGVTGFALGGVLGLFMASMAYDTPLHTPTPANTAATATAGNIGVGGISRTVQQISDLPFRQQMKLQFTDMGKKSYSSAKNFGYIGMIYAGVECVIESLRAKNDIYNGVTAGFFTGAGLAYKAGPQAALMGGAGFAAFSAAIDLYMKSEDGRPPQNDFKE
SIO_010081: YDL217C
subclass of: SO_0000673
so part of: YDL217C
location: complement(67983..68606)
location: region:67983-68606:-1
so has part: feature:67983-68606:-1:exon

NP_010064.1
type: Protein
SIO_000068: ncbiprotein

S000002376
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:67983-68606:-1:exon

YDL216C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CSN5
alternative label: JAB1
gene: RRI1
locus tag: YDL216C
gene synonym: CSN5; JAB1
so part of: sequence
location: complement(<68997..>70319)
location: region:68997-70319:-1
so has part: feature:68997-70319:-1:exon
subclass of: SO_0000010

851310
type: Gene
SIO_000068: ncbigene

position:68997:-1
position: 68997
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70319:-1
position: 70319
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:68997-70319:-1:exon

YDL216C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CSN5
alternative label: JAB1
gene: RRI1
locus tag: YDL216C
gene synonym: CSN5; JAB1
product: COP9 signalosome catalytic subunit RRI1
transcript id: NM_001180276.1
SIO_010081: YDL216C
subclass of: SO_0000673
so part of: YDL216C
location: complement(<68997..>70319)
location: region:68997-70319:-1
so has part: feature:68997-70319:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:68997-70319:-1:exon

YDL216C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CSN5
alternative label: JAB1
gene: RRI1
locus tag: YDL216C
gene synonym: CSN5; JAB1
experiment: EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]
experiment: EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12186635|PMID:12446563|PMID:24164706]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:12446563]
experiment: EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:12183637]
experiment: EXISTENCE:mutant phenotype:GO:0070452 positive regulation of ergosterol biosynthetic process [PMID:24164706]
note: Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis
codon start: 1
product: COP9 signalosome catalytic subunit RRI1
translation: MSLSNKTVKELRQLLKERYTVEDELTESIALSSMRFKPSQEPEFHALSQSSLLKTKLKQQSSTDIPSYTHVLISKLSCEKITHYAVRGGNIEIMGILMGFTLKDNIVVMDCFNLPVVGTETRVNAQLESYEYMVQYIDEMYNHNDGGDGRDYKGAKLNVVGWFHSHPGYDCWLSNIDIQTQDLNQRFQDPYVAIVVDPLKSLEDKILRMGAFRTIESKSDDNSATSYYELETIIFDSELNRALFETKLNLHCVIEDDESEQISLNRLIDSMKQYSYLMDSKNVRTRIKLATTSERVSNENKKNIDYQNRSTRSQFCLNTQRGDSTETSSFGSMFSGDNTSDVDMEDRNLTEFDSTDTSLCINGEPSIHVNRVERSSRSTDNFHNSKKRMNSNQERCHDEGNDMLQRNVLETDYARAKNRILASKIKQYERLRFYKDTFTL
SIO_010081: YDL216C
subclass of: SO_0000673
so part of: YDL216C
location: complement(68997..70319)
location: region:68997-70319:-1
so has part: feature:68997-70319:-1:exon

NP_010065.2
type: Protein
SIO_000068: ncbiprotein

S000002375
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:68997-70319:-1:exon

YDL215C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GDH2
locus tag: YDL215C
so part of: sequence
location: complement(<70640..>73918)
location: region:70640-73918:-1
so has part: feature:70640-73918:-1:exon
subclass of: SO_0000010

851311
type: Gene
SIO_000068: ncbigene

position:70640:-1
position: 70640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73918:-1
position: 73918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70640-73918:-1:exon

YDL215C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GDH2
locus tag: YDL215C
product: glutamate dehydrogenase (NAD(+))
transcript id: NM_001180275.1
SIO_010081: YDL215C
subclass of: SO_0000673
so part of: YDL215C
location: complement(<70640..>73918)
location: region:70640-73918:-1
so has part: feature:70640-73918:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70640-73918:-1:exon

YDL215C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GDH2
locus tag: YDL215C
EC number: 1.4.1.2
experiment: EXISTENCE:direct assay:GO:0004352 glutamate dehydrogenase (NAD+) activity [PMID:6343120]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:6343120]
experiment: EXISTENCE:direct assay:GO:0006807 nitrogen compound metabolic process [PMID:6343120]
experiment: EXISTENCE:mutant phenotype:GO:0004352 glutamate dehydrogenase (NAD+) activity [PMID:1975578]
experiment: EXISTENCE:mutant phenotype:GO:0006807 nitrogen compound metabolic process [PMID:1975578]
note: NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis
codon start: 1
product: glutamate dehydrogenase (NAD(+))
translation: MLFDNKNRGALNSLNTPDIASLSISSMSDYHVFDFPGKDLQREEVIDLLDQQGFIPDDLIEQEVDWFYNSLGIDDLFFSRESPQLISNIIHSLYASKLDFFAKSKFNGIQPRLFSIKNKIITNDNHAIFMESNTGVSISDSQQKNFKFASDAVGNDTLEHGKDTIKKNRIEMDDSCPPYELDSEIDDLFLDNKSQKNCRLVSFWAPESELKLTFVYESVYPNDDPAGVDISSQDLLKGDIESISDKTMYKVSSNENKKLYGLLLKLVKEREGPVIKTTRSVENKDEIRLLVAYKRFTTKRYYSALNSLFHYYKLKPSKFYLESFNVKDDDIIIFSVYLNENQQLEDVLLHDVEAALKQVEREASLLYAIPNNSFHEVYQRRQFSPKEAIYAHIGAIFINHFVNRLGSDYQNLLSQITIKRNDTTLLEIVENLKRKLRNETLTQQTIINIMSKHYTIISKLYKNFAQIHYYHNSTKDMEKTLSFQRLEKVEPFKNDQEFEAYLNKFIPNDSPDLLILKTLNIFNKSILKTNFFITRKVAISFRLDPSLVMTKFEYPETPYGIFFVVGNTFKGFHIRFRDIARGGIRIVCSRNQDIYDLNSKNVIDENYQLASTQQRKNKDIPEGGSKGVILLNPGLVEHDQTFVAFSQYVDAMIDILINDPLKENYVNLLPKEEILFFGPDEGTAGFVDWATNHARVRNCPWWKSFLTGKSPSLGGIPHDEYGMTSLGVRAYVNKIYETLNLTNSTVYKFQTGGPDGDLGSNEILLSSPNECYLAILDGSGVLCDPKGLDKDELCRLAHERKMISDFDTSKLSNNGFFVSVDAMDIMLPNGTIVANGTTFRNTFHTQIFKFVDHVDIFVPCGGRPNSITLNNLHYFVDEKTGKCKIPYIVEGANLFITQPAKNALEEHGCILFKDASANKGGVTSSSMEVLASLALNDNDFVHKFIGDVSGERSALYKSYVVEVQSRIQKNAELEFGQLWNLNQLNGTHISEISNQLSFTINKLNDDLVASQELWLNDLKLRNYLLLDKIIPKILIDVAGPQSVLENIPESYLKVLLSSYLSSTFVYQNGIDVNIGKFLEFIGGLKREAEASA
SIO_010081: YDL215C
subclass of: SO_0000673
so part of: YDL215C
location: complement(70640..73918)
location: region:70640-73918:-1
so has part: feature:70640-73918:-1:exon

NP_010066.1
type: Protein
SIO_000068: ncbiprotein

S000002374
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70640-73918:-1:exon

YDL214C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRR2
locus tag: YDL214C
so part of: sequence
location: complement(<74446..>76545)
location: region:74446-76545:-1
so has part: feature:74446-76545:-1:exon
subclass of: SO_0000010

851312
type: Gene
SIO_000068: ncbigene

position:74446:-1
position: 74446
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:76545:-1
position: 76545
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74446-76545:-1:exon

YDL214C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRR2
locus tag: YDL214C
product: serine/threonine protein kinase PRR2
transcript id: NM_001180274.1
SIO_010081: YDL214C
subclass of: SO_0000673
so part of: YDL214C
location: complement(<74446..>76545)
location: region:74446-76545:-1
so has part: feature:74446-76545:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:74446-76545:-1:exon

YDL214C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRR2
locus tag: YDL214C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]
experiment: EXISTENCE:genetic interaction:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]
experiment: EXISTENCE:mutant phenotype:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]
note: Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog, NPR1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase PRR2
translation: MSLSRILRYNQRNNKTTASLTAEHAYSDNWAYSVSLGDPTSVGVNMAAKTGEALNKSYDSVFSSLPVADSVPRTDFTASSRDDENTDVQKLTTSWMEKIDTKMPENISKIDSNIISSPMVSKVEARFIVPKGRLRKNSTDFTSSFSNSLSLPKSYGKLIFFTSKKNSSSTKKNLANDISDNKHNNNSSNTIGHNIPVTTATATCDEIACTSTEHEYNVYEEERMFTTRVYSLEDSVSSLSTNPLDDTYSEAVQVNTRHIEDTESTAHIRKHSYTTSLSSIKRLFKITSFSNNNSNSCDHQESTVADDCAISSSLKETTSSPVSTGSFSLMIENEDSDRDQIIQALYSNIEASTDLVSRKYRDLDVVLGEGSGGKVKLVQRVLDNKVFALKEYRSKKKRESERKYIKNIISEYCIASTLKNPNICETLEILYEKGKIFQILEYCEYDLFSLVMSEKMHYEEICCLFKQLINGVKYLHDIGLSHRDLKLDNCVVTRRGILKLIDFGASSVFHYPLSSQMIEANGIVGSDPYLSPEVFYFNEYDPRALDVWSVGIIFFCMITRRFPWKYPKVKDVQFKAFCSGRGVSSFKDLVTRPATDDSNNYDNDGYEEGVIDMGPNFILHRLPEETHKIMRRILEVSPFRRITINGILQDGWIKEIETCQVVGAASPNEASLRIINKGNHIHTNIDQRYAHIGGLHQRT
SIO_010081: YDL214C
subclass of: SO_0000673
so part of: YDL214C
location: complement(74446..76545)
location: region:74446-76545:-1
so has part: feature:74446-76545:-1:exon

NP_010067.1
type: Protein
SIO_000068: ncbiprotein

S000002373
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74446-76545:-1:exon

YDL213C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP6
locus tag: YDL213C
so part of: sequence
location: complement(<77289..>77966)
location: region:77289-77966:-1
so has part: feature:77289-77966:-1:exon
subclass of: SO_0000010

851313
type: Gene
SIO_000068: ncbigene

position:77289:-1
position: 77289
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77966:-1
position: 77966
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:77289-77966:-1:exon

YDL213C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP6
locus tag: YDL213C
product: Nop6p
transcript id: NM_001180273.1
SIO_010081: YDL213C
subclass of: SO_0000673
so part of: YDL213C
location: complement(<77289..>77966)
location: region:77289-77966:-1
so has part: feature:77289-77966:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:77289-77966:-1:exon

YDL213C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP6
locus tag: YDL213C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:17425675|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21282979]
experiment: EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:21893585]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:22588997|PMID:21282979]
experiment: EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:17425675]
note: rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
codon start: 1
product: Nop6p
translation: MGSEEDKKLTKKQLKAQQFRKSKEEKDQEKDVKKEQAPEGKRPNSAAGNDGEEPVKKKRKTRRGRGGKGKNGKKGNRFIVFVGSLPRDITAVELQNHFKNSSPDQIRLRADKGIAFLEFDADKDRTGIQRRMDIALLQHGTLLKEKKINVELTVGGGGNSQERLEKLKNKNIKLDEERKERLTKMINDGNQKKIAKTTATAAQTSGTDNKPVPAGIHPDRAKLLK
SIO_010081: YDL213C
subclass of: SO_0000673
so part of: YDL213C
location: complement(77289..77966)
location: region:77289-77966:-1
so has part: feature:77289-77966:-1:exon

NP_010068.1
type: Protein
SIO_000068: ncbiprotein

S000002372
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:77289-77966:-1:exon

YDL212W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APF1
gene: SHR3
locus tag: YDL212W
gene synonym: APF1
so part of: sequence
location: <78426..>79058
location: region:78426-79058:1
so has part: feature:78426-79058:1:exon
subclass of: SO_0000010

851314
type: Gene
SIO_000068: ncbigene

position:78426:1
position: 78426
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:79058:1
position: 79058
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78426-79058:1:exon

YDL212W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APF1
gene: SHR3
locus tag: YDL212W
gene synonym: APF1
product: Shr3p
transcript id: NM_001180272.1
SIO_010081: YDL212W
subclass of: SO_0000673
so part of: YDL212W
location: <78426..>79058
location: region:78426-79058:1
so has part: feature:78426-79058:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78426-79058:1:exon

YDL212W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APF1
gene: SHR3
locus tag: YDL212W
gene synonym: APF1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:1423607|PMID:15623581]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0090114 COPII-coated vesicle budding [PMID:10564255]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:10564255|PMID:15623581]
note: Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
codon start: 1
product: Shr3p
translation: MFSYSDFCSIGTAMILSATTFLMGVFFSNMPYDYHLLFNPNSTQEHFDLALRHYQILHETPLPVIVTLCVVAGIGLVGGTIKVFKPNPELQMFEYCSLGLYVLAICVFLTNVKTGIDCSVSHNWGEVTENQGLAVIASSNIILLVMFAGVIILQIGLWYSNWDLQKRLKEFYAQEEREAANAGKKTEKVDNAKKNDNKSKGAQKRKNAKK
SIO_010081: YDL212W
subclass of: SO_0000673
so part of: YDL212W
location: 78426..79058
location: region:78426-79058:1
so has part: feature:78426-79058:1:exon

NP_010069.1
type: Protein
SIO_000068: ncbiprotein

S000002371
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78426-79058:1:exon

YDL211C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL211C
so part of: sequence
location: complement(<79294..>80412)
location: region:79294-80412:-1
so has part: feature:79294-80412:-1:exon
subclass of: SO_0000010

851315
type: Gene
SIO_000068: ncbigene

position:79294:-1
position: 79294
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80412:-1
position: 80412
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:79294-80412:-1:exon

YDL211C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL211C
product: uncharacterized protein
transcript id: NM_001180271.1
SIO_010081: YDL211C
subclass of: SO_0000673
so part of: YDL211C
location: complement(<79294..>80412)
location: region:79294-80412:-1
so has part: feature:79294-80412:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:79294-80412:-1:exon

YDL211C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL211C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL211C has a paralog, TDA7, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MLLNVTSSQYISTPQSRSLSEIDTSETASLSSATDHIFALSTEVVSSITTNLIEGLESSIQVPISTAYGTTSFRNNTSSPQYLVSNCTSSVQSNITIDRGLLSTLKTFTTSQVPTIEPSTTKLTTPLSTTFTSTSTSEIYSVFTSENSVYIIYDQEYKFTERSTTFNTHFPQTTVLQESNPPLTFTIPSNTITGDAKLYQYLSGALNTQDTSDANNRRTGVIVGSTVGVVIGVVIVIFIGFIIIRNRRNVKNHSKKGFSHDIGKRVSCDEVTETEAPSNPFLNVLNYKVTTNGEGKRDSFENGRDLHRASSSDGIYIAHPYYGMADHESGRFSYVSSYNESAESSIEETSSSASTITRPNIQQTNSFLREII
SIO_010081: YDL211C
subclass of: SO_0000673
so part of: YDL211C
location: complement(79294..80412)
location: region:79294-80412:-1
so has part: feature:79294-80412:-1:exon

NP_010070.1
type: Protein
SIO_000068: ncbiprotein

S000002370
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:79294-80412:-1:exon

YNCD0001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0001W
so part of: sequence
location: 83548..83618
location: region:83548-83618:1
so has part: feature:83548-83618:1:exon
subclass of: SO_0000663

851316
type: Gene
SIO_000068: ncbigene

position:83548:1
position: 83548
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:83618:1
position: 83618
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:83548-83618:1:exon

YNCD0001W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0001W
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis
SIO_010081: YNCD0001W
subclass of: SO_0000673
so part of: YNCD0001W
location: 83548..83618
location: region:83548-83618:1
so has part: feature:83548-83618:1:exon

S000006576
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:83548-83618:1:exon

YDL210W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UGA4
locus tag: YDL210W
so part of: sequence
location: <84270..>85985
location: region:84270-85985:1
so has part: feature:84270-85985:1:exon
subclass of: SO_0000010

851317
type: Gene
SIO_000068: ncbigene

position:84270:1
position: 84270
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85985:1
position: 85985
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84270-85985:1:exon

YDL210W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UGA4
locus tag: YDL210W
product: Uga4p
transcript id: NM_001180270.1
SIO_010081: YDL210W
subclass of: SO_0000673
so part of: YDL210W
location: <84270..>85985
location: region:84270-85985:1
so has part: feature:84270-85985:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:84270-85985:1:exon

YDL210W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UGA4
locus tag: YDL210W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14985124|PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0015495 gamma-aminobutyric acid:proton symporter activity [PMID:8455553]
experiment: EXISTENCE:genetic interaction:GO:0015812 gamma-aminobutyric acid transport [PMID:8455553]
experiment: EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:8455553]
experiment: EXISTENCE:mutant phenotype:GO:0015489 putrescine transmembrane transporter activity [PMID:14985124]
experiment: EXISTENCE:mutant phenotype:GO:0015812 gamma-aminobutyric acid transport [PMID:14985124]
experiment: EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:14985124]
note: GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
codon start: 1
product: Uga4p
translation: MSMSSKNENKISVEQRISTDIGQAYQLQGLGSNLRSIRSKTGAGEVNYIDAAKSVNDNQLLAEIGYKQELKRQFSTLQVFGIAFSIMGLLPSIASVMGGGLGGGPATLVWGWFVAAFFILLVGITMAEHASSIPTAGGLYYWTYYYAPEGYKEIISFIIGCSNSLALAAGVCSIDYGLAEEIAAAVTLTKDGNFEVTSGKLYGIFAGAVVVMCICTCVASGAIARLQTLSIFANLFIIVLLFIALPIGTKHRMGGFNDGDFIFGKYENLSDWNNGWQFCLAGFMPAVWTIGSFDSCVHQSEEAKDAKKSVPIGIISSIAVCWILGWLIIICLMACINPDIDSVLDSKYGFALAQIIYDSLGKKWAIAFMSLIAFCQFLMGASITTAVSRQVWAFSRDNGLPLSKYIKRVDSKYSVPFFAILAACVGSLILGLLCLIDDAATDALFSLAVAGNNLAWSTPTVFRLTSGRDLFRPGPFYLGKIWSPIVAWTGVAFQLFIIILVMFPSQQHGITKSTMNYACVIGPGIWILAGIYYKVYKKKYYHGPATNLSDDDYTEAVGADVIDTIMSKQEP
SIO_010081: YDL210W
subclass of: SO_0000673
so part of: YDL210W
location: 84270..85985
location: region:84270-85985:1
so has part: feature:84270-85985:1:exon

NP_010071.1
type: Protein
SIO_000068: ncbiprotein

S000002369
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84270-85985:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS405; Autonomously Replicating Sequence
so part of: sequence
location: 85945..86176
location: region:85945-86176:1
so has part: feature:85945-86176:1:region

S000118428
type: SGD
SIO_000068: sgd

position:85945:1
position: 85945
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:86176:1
position: 86176
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85945-86176:1:region

YDL209C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NTC40
gene: CWC2
locus tag: YDL209C
gene synonym: NTC40
so part of: sequence
location: complement(<86207..>87226)
location: region:86207-87226:-1
so has part: feature:86207-87226:-1:exon
subclass of: SO_0000010

851318
type: Gene
SIO_000068: ncbigene

position:86207:-1
position: 86207
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:87226:-1
position: 87226
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:86207-87226:-1:exon

YDL209C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NTC40
gene: CWC2
locus tag: YDL209C
gene synonym: NTC40
product: Cwc2p
transcript id: NM_001180269.1
SIO_010081: YDL209C
subclass of: SO_0000673
so part of: YDL209C
location: complement(<86207..>87226)
location: region:86207-87226:-1
so has part: feature:86207-87226:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:86207-87226:-1:exon

YDL209C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NTC40
gene: CWC2
locus tag: YDL209C
gene synonym: NTC40
experiment: EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:19435883]
experiment: EXISTENCE:curator inference:GO:0000386 second spliceosomal transesterification activity [PMID:19435883]
experiment: EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:19435883]
experiment: EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:19435883]
experiment: EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:19435883]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12088152]
experiment: EXISTENCE:physical interaction:GO:0000974 Prp19 complex [PMID:12088152]
note: Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
codon start: 1
product: Cwc2p
translation: MTSWRDKSAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSPFALQPQLHSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDIGKLALRTEVLDCFGREKFADYREDMGGIGSFRKKNKTLYVGGIDGALNSKHLKPAQIESRIRFVFSRLGDIDRIRYVESKNCGFVKFKYQANAEFAKEAMSNQTLLLPSDKEWDDRREGTGLLVKWANEDPDPAAQKRLQEELKLESLNMMVHLINNNTNSAGTEVNNKNNERLDRTFPEASVDNVKKRLLPLDNGMESDDFIEKLKKVKKNISRENISSKPSVGKLGGPLLDYLSSDED
SIO_010081: YDL209C
subclass of: SO_0000673
so part of: YDL209C
location: complement(86207..87226)
location: region:86207-87226:-1
so has part: feature:86207-87226:-1:exon

NP_010072.1
type: Protein
SIO_000068: ncbiprotein

S000002368
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:86207-87226:-1:exon

YDL208W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NHP2
locus tag: YDL208W
so part of: sequence
location: <87512..>87982
location: region:87512-87982:1
so has part: feature:87512-87982:1:exon
subclass of: SO_0000010

851319
type: Gene
SIO_000068: ncbigene

position:87512:1
position: 87512
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:87982:1
position: 87982
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:87512-87982:1:exon

YDL208W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NHP2
locus tag: YDL208W
product: snoRNA-binding protein NHP2
transcript id: NM_001180268.1
SIO_010081: YDL208W
subclass of: SO_0000673
so part of: YDL208W
location: <87512..>87982
location: region:87512-87982:1
so has part: feature:87512-87982:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:87512-87982:1:exon

YDL208W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NHP2
locus tag: YDL208W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11433018|PMID:9843512]
experiment: EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:direct assay:GO:0034513 box H/ACA snoRNA binding [PMID:11433018]
experiment: EXISTENCE:mutant phenotype:GO:0000469 cleavage involved in rRNA processing [PMID:9843512]
experiment: EXISTENCE:mutant phenotype:GO:0000493 box H/ACA snoRNP assembly [PMID:11433018]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9843512]
experiment: EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9843512]
note: Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
codon start: 1
product: snoRNA-binding protein NHP2
translation: MGKDNKEHKESKESKTVDNYEARMPAVLPFAKPLASKKLNKKVLKTVKKASKAKNVKRGVKEVVKALRKGEKGLVVIAGDISPADVISHIPVLCEDHSVPYIFIPSKQDLGAAGATKRPTSVVFIVPGSNKKKDGKNKEEEYKESFNEVVKEVQAL
SIO_010081: YDL208W
subclass of: SO_0000673
so part of: YDL208W
location: 87512..87982
location: region:87512-87982:1
so has part: feature:87512-87982:1:exon

NP_010073.2
type: Protein
SIO_000068: ncbiprotein

S000002367
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:87512-87982:1:exon

YDL207W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BRR3
alternative label: NLE2
alternative label: RSS1
gene: GLE1
locus tag: YDL207W
gene synonym: BRR3; NLE2; RSS1
so part of: sequence
location: <88248..>89864
location: region:88248-89864:1
so has part: feature:88248-89864:1:exon
subclass of: SO_0000010

851320
type: Gene
SIO_000068: ncbigene

position:88248:1
position: 88248
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:89864:1
position: 89864
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:88248-89864:1:exon

YDL207W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BRR3
alternative label: NLE2
alternative label: RSS1
gene: GLE1
locus tag: YDL207W
gene synonym: BRR3; NLE2; RSS1
product: nucleoporin GLE1
transcript id: NM_001180267.1
SIO_010081: YDL207W
subclass of: SO_0000673
so part of: YDL207W
location: <88248..>89864
location: region:88248-89864:1
so has part: feature:88248-89864:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:88248-89864:1:exon

YDL207W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BRR3
alternative label: NLE2
alternative label: RSS1
gene: GLE1
locus tag: YDL207W
gene synonym: BRR3; NLE2; RSS1
experiment: EXISTENCE:direct assay:GO:0000822 inositol hexakisphosphate binding [PMID:16783363]
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:15459192]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10610322]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006409 tRNA export from nucleus [PMID:31453808]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16783364]
experiment: EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:10610322]
experiment: EXISTENCE:genetic interaction:GO:0008047 enzyme activator activity [PMID:16783364]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:20371601]
experiment: EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:18724935]
experiment: EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:20371601]
experiment: EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:16783364]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8898365|PMID:27385342]
experiment: EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:18724935]
note: Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination
codon start: 1
product: nucleoporin GLE1
translation: MRFVFDEVFNSDTDSPEFEETCSTTSSTSSQCPTPEPSPAIKLPSFTKVGTKKLVNESVVILDPALENALRDLNLQSKLIPINEPIVAASSIIVPHSTNMPLPRASHSSLLDNAKNSNATAPLLEAIEESFQRKMQNLVLANQKEIQSIRENKRRVEEQRKRKEEEERKRKEAEEKAKREQELLRQKKDEEERKRKEAEAKLAQQKQEEERKKIEEQNEKERQLKKEHEAKLLQQKDKLGKAVTNFDKISKMFWHYKDKIAQIKQDIVLPIKKADVNVRNLLSRHKRKINPKFGQLTNSNQQLFKIQNELTQLINDTKGDSLAYHWILNFIAKAVVHQAETEVRVKPESALPLGKLTLYLLVQFPELQELFMARLVKKCPFVIGFTCEIDTEKGRQNMGWKRNNENKWEDNTSYDERMGGILSLFAIITRLQLPQEFITTTSHPFPIALSWHILARICNTPLNLITNTHFVILGSWWDAAAVQFLQAYGNQASKLLILIGEELTSRMAEKKYVGAARLRILLEAWQNNNMESFPEMSP
SIO_010081: YDL207W
subclass of: SO_0000673
so part of: YDL207W
location: 88248..89864
location: region:88248-89864:1
so has part: feature:88248-89864:1:exon

NP_010074.1
type: Protein
SIO_000068: ncbiprotein

S000002366
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:88248-89864:1:exon

YDL206W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL206W
so part of: sequence
location: <90176..>92464
location: region:90176-92464:1
so has part: feature:90176-92464:1:exon
subclass of: SO_0000010

851321
type: Gene
SIO_000068: ncbigene

position:90176:1
position: 90176
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:92464:1
position: 92464
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:90176-92464:1:exon

YDL206W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL206W
product: uncharacterized protein
transcript id: NM_001180266.1
SIO_010081: YDL206W
subclass of: SO_0000673
so part of: YDL206W
location: <90176..>92464
location: region:90176-92464:1
so has part: feature:90176-92464:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:90176-92464:1:exon

YDL206W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL206W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
note: hypothetical protein; YDL206W is not an essential protein
codon start: 1
product: uncharacterized protein
translation: MHKPLRWLITIAFYVSNVILIGYSLSSNGSISEFYLHSVVLIECFSLLGVVTSDCLTPSLSYISSNIFHISDRVSGMTLLALGNALPDITSTYQSMKSGVTSLAIGELFGGIFFLLTVVIGLMGCVATIQFQHDKSIETYTEESFDQNLSYDRSNYILDVGIFTFMLLVSGTFLADGRLYFWECIVMVLTYCCCAVYLIKSYKYPCEINDALEREVEIKKTVLANNHITVPNRFTLTTTSDITSTDDGIRYVRPLGDTQIDEDNAISLDPTRLPSKSLDNISRFNQGIPERRDLIRRRIRGYLRSHYHGWVRMTLQDLLNIWEKQNLFNNTVKSLSLPSDDTHLFTKASLDEEGRPLIRKRMNSLQPKDFYKYLSLRNGENSNALDTAISAPQNEYQTYYNEPTSLFLTVPQKKTSKKSLSCDRIPNLVRSNNIILNDEATRTQESTNALNSISDVIDNSLLQYERDDIILDRTLSLCSTKSRTAWHSFQLYNYLTDVSLEIGFFEFLSLLVTTPVSIILYLSIPSEISQTDHDLPLSYLQNIQLIASPIILNQLITNNFSFWLLILSLVIAILLYFKTRTIPNKFNSDIIFTVAFLLSLACLSKAVHIIVVTLTHWINVFNISETILGLTIFTWGNSIGDLVSNITFVKIGVLEIAIGACFGSPLLYFLFGVGFDGIMIMLGDKTGKIVSGRDSNILMHHIDFKVDKNLINTGVGILIAFLIFTVLIPLNDWKIDKKISIALLTLYIVVTCISVFLEVHQV
SIO_010081: YDL206W
subclass of: SO_0000673
so part of: YDL206W
location: 90176..92464
location: region:90176-92464:1
so has part: feature:90176-92464:1:exon

NP_010075.1
type: Protein
SIO_000068: ncbiprotein

S000002365
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:90176-92464:1:exon

YDL205C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OLE2
gene: HEM3
locus tag: YDL205C
gene synonym: OLE2
so part of: sequence
location: complement(<92762..>93745)
location: region:92762-93745:-1
so has part: feature:92762-93745:-1:exon
subclass of: SO_0000010

851322
type: Gene
SIO_000068: ncbigene

position:92762:-1
position: 92762
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:93745:-1
position: 93745
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92762-93745:-1:exon

YDL205C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OLE2
gene: HEM3
locus tag: YDL205C
gene synonym: OLE2
product: hydroxymethylbilane synthase
transcript id: NM_001180265.1
SIO_010081: YDL205C
subclass of: SO_0000673
so part of: YDL205C
location: complement(<92762..>93745)
location: region:92762-93745:-1
so has part: feature:92762-93745:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:92762-93745:-1:exon

YDL205C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OLE2
gene: HEM3
locus tag: YDL205C
gene synonym: OLE2
EC number: 2.5.1.61
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004418 hydroxymethylbilane synthase activity [PMID:1508149|PMID:323256]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:14559249|PMID:323256]
note: Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
codon start: 1
product: hydroxymethylbilane synthase
translation: MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKILAERMIADGAKKILDEINLDRIK
SIO_010081: YDL205C
subclass of: SO_0000673
so part of: YDL205C
location: complement(92762..93745)
location: region:92762-93745:-1
so has part: feature:92762-93745:-1:exon

NP_010076.1
type: Protein
SIO_000068: ncbiprotein

S000002364
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92762-93745:-1:exon

YDL204W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTN2
locus tag: YDL204W
so part of: sequence
location: <94605..>95786
location: region:94605-95786:1
so has part: feature:94605-95786:1:exon
subclass of: SO_0000010

851323
type: Gene
SIO_000068: ncbigene

position:94605:1
position: 94605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:95786:1
position: 95786
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94605-95786:1:exon

YDL204W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTN2
locus tag: YDL204W
product: Rtn2p
transcript id: NM_001180264.1
SIO_010081: YDL204W
subclass of: SO_0000673
so part of: YDL204W
location: <94605..>95786
location: region:94605-95786:1
so has part: feature:94605-95786:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94605-95786:1:exon

YDL204W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTN2
locus tag: YDL204W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:17905927]
experiment: EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:16469703]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]
experiment: EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]
experiment: EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:27117666]
experiment: EXISTENCE:genetic interaction:GO:0071786 endoplasmic reticulum tubular network organization [PMID:16469703|PMID:18309084|PMID:18442980]
experiment: EXISTENCE:genetic interaction:GO:0071788 endoplasmic reticulum tubular network maintenance [PMID:21502358]
note: Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress
codon start: 1
product: Rtn2p
translation: MNRNTTTNKNANLNNSRNANAPGEAGHQNKTGLIYWTNPSKSGASFAATLVSLLILRNVNVISVLLKIGYMVLFTSFAVELSTKVLFDKGVVSRFGMQESPDLVGVLKPHIDRELDRLPALEDRIRKLVFAHRTRNNFTIGVSLYFLHGLFAIFSMNTVLIMTTIFLYTVPLIYDRKQARIDRAIDRMKDLVIHRFHKNYNKVVEKTEPYIDKIIPPQTDEGSYSTSISNENKSSTSQRNKSGLSSSEFDNMNDTSASKSGKDSYSTSQYNRAEYPVSQNENIGTLKSGKQEIPTEKDFNNRHENFSKPDVKTYDPRTVDIEEELAAHQRELEQNLKDGDYNLVGSKEIPDPITVPAPTRHTTKPAESQSIPIKNNETLHKTTHGLKQKLQHA
SIO_010081: YDL204W
subclass of: SO_0000673
so part of: YDL204W
location: 94605..95786
location: region:94605-95786:1
so has part: feature:94605-95786:1:exon

NP_010077.1
type: Protein
SIO_000068: ncbiprotein

S000002363
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94605-95786:1:exon

YDL203C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ACK1
locus tag: YDL203C
so part of: sequence
location: complement(<96082..>97953)
location: region:96082-97953:-1
so has part: feature:96082-97953:-1:exon
subclass of: SO_0000010

851324
type: Gene
SIO_000068: ncbigene

position:96082:-1
position: 96082
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:97953:-1
position: 97953
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96082-97953:-1:exon

YDL203C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ACK1
locus tag: YDL203C
product: Ack1p
transcript id: NM_001180263.1
SIO_010081: YDL203C
subclass of: SO_0000673
so part of: YDL203C
location: complement(<96082..>97953)
location: region:96082-97953:-1
so has part: feature:96082-97953:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:96082-97953:-1:exon

YDL203C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ACK1
locus tag: YDL203C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0009967 positive regulation of signal transduction [PMID:18806213]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:18806213]
note: Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
codon start: 1
product: Ack1p
translation: MVNQGQPQPNLYDKHINMFPPARARESSHKLGNANSDRHGLPAQNIVPAPYPVDDSIVELTPAIPFTSPSSSSSLSLPLSALNFTDGNADGGQLGTPVTINSNNGMDIFNSKPTGEIGYANNGTNSTGSRYELPFNFSSTKESLGSPAVQDASISSGNRISESVRDNSAPPPYEESESRILQEKVYRTEEKAPIRPLNNNPVPPQKINQPPTGSAKTDDNGSSGGEDKLSSYSPEALAFYQVYKKTITDSSKFTPEIQMQWCETLLTYAFNEDFISQYNINAEKLKRSLKPEEMLKNQKVILEHSFKVLTKLITLKWPPAMYLMGTLYSHQPYLPIKNKNIVIKNDEKALEYYCKAAKLNNSDACYRAGVCFEYQRGTSSLDPSPTKEQCIKKAFQYYQHGAEVCSNSACMYKLGMSHLYGLNMQKTDVLLAIKWFDKAAQKGDSPQTLYELGKIYEFSVLPPEIQNLLFANGIRKDSQLAIKYYQQCAKDFEYPLAQWKLGNCYEFGDLGLPVVAKKSIYWYSKAAAAQPKGNPMAMLSLSGWYLTGAPNILKPNNKEAFNWALKSSKCSDGKLARTEFALGFYYEKGVGCEVDLDLAKQYYQRAARMGFRKAVDALRSLTN
SIO_010081: YDL203C
subclass of: SO_0000673
so part of: YDL203C
location: complement(96082..97953)
location: region:96082-97953:-1
so has part: feature:96082-97953:-1:exon

NP_010078.1
type: Protein
SIO_000068: ncbiprotein

S000002362
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:96082-97953:-1:exon

YDL202W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL10m
gene: MRPL11
locus tag: YDL202W
gene synonym: uL10m
so part of: sequence
location: <98475..>99224
location: region:98475-99224:1
so has part: feature:98475-99224:1:exon
subclass of: SO_0000010

851325
type: Gene
SIO_000068: ncbigene

position:98475:1
position: 98475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:99224:1
position: 99224
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98475-99224:1:exon

YDL202W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL10m
gene: MRPL11
locus tag: YDL202W
gene synonym: uL10m
product: mitochondrial 54S ribosomal protein YmL11
transcript id: NM_001180262.1
SIO_010081: YDL202W
subclass of: SO_0000673
so part of: YDL202W
location: <98475..>99224
location: region:98475-99224:1
so has part: feature:98475-99224:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98475-99224:1:exon

YDL202W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL10m
gene: MRPL11
locus tag: YDL202W
gene synonym: uL10m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2
codon start: 1
product: mitochondrial 54S ribosomal protein YmL11
translation: MLQLRFMPGWVPRNGFFGLKETIGTVHKRFYALASEQPSRKTVKPLDSRKTFLIDTYKHLMENSSMIFFVHYNNLSKTEDHHFRFKIKQTGGKLTKVRNNLFEVYLRNSHLPDPCGFVKRKEQNWKHPLLPLLKGPTATITYEDTNPQQVAKLLKVLQSAQDKLMVIGAKVENEVLNVEKINTFKTLPTKPEMQSQLVSVLQMLSGLGLVRTLENSSNALYLTLKSHNDNQKPKEDVESTTDAESKGSK
SIO_010081: YDL202W
subclass of: SO_0000673
so part of: YDL202W
location: 98475..99224
location: region:98475-99224:1
so has part: feature:98475-99224:1:exon

NP_010079.1
type: Protein
SIO_000068: ncbiprotein

S000002361
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98475-99224:1:exon

YDL201W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRM8
locus tag: YDL201W
so part of: sequence
location: <99561..>100421
location: region:99561-100421:1
so has part: feature:99561-100421:1:exon
subclass of: SO_0000010

851326
type: Gene
SIO_000068: ncbigene

position:99561:1
position: 99561
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:100421:1
position: 100421
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:99561-100421:1:exon

YDL201W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRM8
locus tag: YDL201W
product: tRNA (guanine46-N7)-methyltransferase
transcript id: NM_001180261.1
SIO_010081: YDL201W
subclass of: SO_0000673
so part of: YDL201W
location: <99561..>100421
location: region:99561-100421:1
so has part: feature:99561-100421:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:99561-100421:1:exon

YDL201W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRM8
locus tag: YDL201W
EC number: 2.1.1.33
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008176 tRNA (guanine-N7-)-methyltransferase activity [PMID:17382321]
experiment: EXISTENCE:direct assay:GO:0106004 tRNA (guanine-N7)-methylation [PMID:17382321]
experiment: EXISTENCE:direct assay:GO:0106143 tRNA (m7G46) methyltransferase complex [PMID:12403464|PMID:17382321|PMID:18184583]
experiment: EXISTENCE:mutant phenotype:GO:0008176 tRNA (guanine-N7-)-methyltransferase activity [PMID:12403464]
experiment: EXISTENCE:mutant phenotype:GO:0106004 tRNA (guanine-N7)-methylation [PMID:12403464]
note: Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
codon start: 1
product: tRNA (guanine46-N7)-methyltransferase
translation: MKAKPLSQDPGSKRYAYRINKEENRKELKHVKINESSLVQEGQKIDLPKKRYYRQRAHSNPFSDHQLEYPVSPQDMDWSKLYPYYKNAENGQMTKKVTIADIGCGFGGLMIDLSPAFPEDLILGMEIRVQVTNYVEDRIIALRNNTASKHGFQNINVLRGNAMKFLPNFFEKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLKEGGVVYTITDVKDLHEWMVKHLEEHPLFERLSKEWEENDECVKIMRNATEEGKKVERKKGDKFVACFTRLPTPAIL
SIO_010081: YDL201W
subclass of: SO_0000673
so part of: YDL201W
location: 99561..100421
location: region:99561-100421:1
so has part: feature:99561-100421:1:exon

NP_010080.1
type: Protein
SIO_000068: ncbiprotein

S000002360
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:99561-100421:1:exon

YDL200C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MGT1
locus tag: YDL200C
so part of: sequence
location: complement(<100501..>101067)
location: region:100501-101067:-1
so has part: feature:100501-101067:-1:exon
subclass of: SO_0000010

851327
type: Gene
SIO_000068: ncbigene

position:100501:-1
position: 100501
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:101067:-1
position: 101067
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100501-101067:-1:exon

YDL200C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MGT1
locus tag: YDL200C
product: methylated-DNA--protein-cysteine methyltransferase
transcript id: NM_001180260.1
SIO_010081: YDL200C
subclass of: SO_0000673
so part of: YDL200C
location: complement(<100501..>101067)
location: region:100501-101067:-1
so has part: feature:100501-101067:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:100501-101067:-1:exon

YDL200C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MGT1
locus tag: YDL200C
EC number: 2.1.1.63
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:1641326]
experiment: EXISTENCE:direct assay:GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity [PMID:2403555|PMID:2065659]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:mutant phenotype:GO:0006307 DNA dealkylation involved in DNA repair [PMID:1641326]
note: DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; localizes to the peroxisome in a Pex5p-dependent manner
codon start: 1
product: methylated-DNA--protein-cysteine methyltransferase
translation: MKELLYYTFIETEVTGAFLVFREKTQNLVFASLGNDKLFLLGKVEGFLKKHEKQDTMYDLQELKEAETYKKSIENYTICLENKMPLPSGAIPFEFLFGTDFQRKVWNELLNVEHGHVVTYGDIAKRIGKPTAARSVGRACGSNNLALLVPCHRIVGSNRKLTGYKWSCKLKEQLLNNEKENSLSLSRL
SIO_010081: YDL200C
subclass of: SO_0000673
so part of: YDL200C
location: complement(100501..101067)
location: region:100501-101067:-1
so has part: feature:100501-101067:-1:exon

NP_010081.2
type: Protein
SIO_000068: ncbiprotein

S000002359
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100501-101067:-1:exon

YDL199C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL199C
so part of: sequence
location: complement(<101290..>103353)
location: region:101290-103353:-1
so has part: feature:101290-103353:-1:exon
subclass of: SO_0000010

851328
type: Gene
SIO_000068: ncbigene

position:101290:-1
position: 101290
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:103353:-1
position: 103353
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:101290-103353:-1:exon

YDL199C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL199C
product: uncharacterized protein
transcript id: NM_001180259.1
SIO_010081: YDL199C
subclass of: SO_0000673
so part of: YDL199C
location: complement(<101290..>103353)
location: region:101290-103353:-1
so has part: feature:101290-103353:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:101290-103353:-1:exon

YDL199C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL199C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
note: Putative transporter; member of the sugar porter family
codon start: 1
product: uncharacterized protein
translation: MKPPLNMSRSNKPLTQEANSSAHIDRAHQLAQDFNSKQDDTALTSLPHKNPDIFRFENNITAHSSRRGSLYRDSDATVVLPLSEHTPRLSMDDPYRQLLQQAEISQLRSKKKRHSSRVLRTSFISFVVLVSSLSGLDQGLISGNVMTLSFQKYFHYPLTSPLGNIVSIVNLGAFMASLFVYSGILEPCSRKKMLQISTMIYSLGAIVQVLALNQWCLLLGRFLLGVGMGFAFSMVIIYQFEFPLPCIRKRTLISIQCVSSVIAYSFGIWINCAFRYLGFAWRYPLSTHVALGIILNLMSFYLILESPSWLLKQKNDVEALVLISNVFDDGNFEENQTQLKFRVLKRDILLKSHLQKNSYPYAYILKDFSSIIKLLIGFQLLTRTNGVDAFLYYSPLILQQMGRGERKSIYLTGLNALIYSIVILAYVPLVLRKRKEKTNVLLGSIVMCALLFTISFTDWFPKSTTRYISILFAVFLFTHFISWDSIGWVMTIELLPHLSQAPVILLVSNFYWIFKWFVSLITPILIDRLSWKFYLIPSLSSFISIIFVLKIFPIETRDERLDSDDDSTGNGSGNHDDVFDDTGSEFSSSPSFSAYQINTLGSSIKQNNQAYSSIQNEQILPKNGNLSNQTHGSAQNVYFITSDSGPSRTGEFFSFHNRTDPNISDNIAANKPSSGGGQNSPGDMAVA
SIO_010081: YDL199C
subclass of: SO_0000673
so part of: YDL199C
location: complement(101290..103353)
location: region:101290-103353:-1
so has part: feature:101290-103353:-1:exon

NP_010082.1
type: Protein
SIO_000068: ncbiprotein

S000002358
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:101290-103353:-1:exon

YDL198C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SHM1
alternative label: YHM1
gene: GGC1
locus tag: YDL198C
gene synonym: SHM1; YHM1
so part of: sequence
location: complement(<103649..>104551)
location: region:103649-104551:-1
so has part: feature:103649-104551:-1:exon
subclass of: SO_0000010

851329
type: Gene
SIO_000068: ncbigene

position:103649:-1
position: 103649
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:104551:-1
position: 104551
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:103649-104551:-1:exon

YDL198C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SHM1
alternative label: YHM1
gene: GGC1
locus tag: YDL198C
gene synonym: SHM1; YHM1
product: Ggc1p
transcript id: NM_001180258.1
SIO_010081: YDL198C
subclass of: SO_0000673
so part of: YDL198C
location: complement(<103649..>104551)
location: region:103649-104551:-1
so has part: feature:103649-104551:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:103649-104551:-1:exon

YDL198C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SHM1
alternative label: YHM1
gene: GGC1
locus tag: YDL198C
gene synonym: SHM1; YHM1
experiment: EXISTENCE:direct assay:GO:0001408 guanine nucleotide transport [PMID:14998997]
experiment: EXISTENCE:direct assay:GO:0001409 guanine nucleotide transmembrane transporter activity [PMID:14998997]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:14998997]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:14998997]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:14629196]
note: Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
codon start: 1
product: Ggc1p
translation: MPHTDKKQSGLARLLGSASAGIMEIAVFHPVDTISKRLMSNHTKITSGQELNRVIFRDHFSEPLGKRLFTLFPGLGYAASYKVLQRVYKYGGQPFANEFLNKHYKKDFDNLFGEKTGKAMRSAAAGSLIGIGEIVLLPLDVLKIKRQTNPESFKGRGFIKILRDEGLFNLYRGWGWTAARNAPGSFALFGGNAFAKEYILGLKDYSQATWSQNFISSIVGACSSLIVSAPLDVIKTRIQNRNFDNPESGLRIVKNTLKNEGVTAFFKGLTPKLLTTGPKLVFSFALAQSLIPRFDNLLSK
SIO_010081: YDL198C
subclass of: SO_0000673
so part of: YDL198C
location: complement(103649..104551)
location: region:103649-104551:-1
so has part: feature:103649-104551:-1:exon

NP_010083.1
type: Protein
SIO_000068: ncbiprotein

S000002357
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:103649-104551:-1:exon

YDL197C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ASF2
locus tag: YDL197C
so part of: sequence
location: complement(<104917..>106494)
location: region:104917-106494:-1
so has part: feature:104917-106494:-1:exon
subclass of: SO_0000010

851330
type: Gene
SIO_000068: ncbigene

position:104917:-1
position: 104917
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:106494:-1
position: 106494
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:104917-106494:-1:exon

YDL197C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ASF2
locus tag: YDL197C
product: Asf2p
transcript id: NM_001180257.1
SIO_010081: YDL197C
subclass of: SO_0000673
so part of: YDL197C
location: complement(<104917..>106494)
location: region:104917-106494:-1
so has part: feature:104917-106494:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:104917-106494:-1:exon

YDL197C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ASF2
locus tag: YDL197C
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:15282802]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:9290207]
note: Anti-silencing protein; causes derepression of silent loci when overexpressed
codon start: 1
product: Asf2p
translation: MPKNRGVLDAITRSVIDGSDQESSSSFNSDKEYAAVTKGLSSSRVQKKSSLRQMKSKVKELQSLVNHYRENEAALVSSAKLLSGEIIGYEIKMASLHGKMKSILDENNALKETHKSSAEKRIELVRLPSSKEERNYDEYTLLVNLKKEICAKLQDYKNVQNTVNTKLDEIHTFHEKYYEGLELSLDSKVFDAESSKELAKVRRELNNVRKNSEIKVNNLKMQLLQATKSLEHLKKQAKAKDDYLKCIPELVDKANLTMLSYKKSIANQRETIEALQAELSQQSETKGQIETETQNQVQIPTNVTLVDPFEENNPEDLFAIQEQELQDLRLHKKMADERSRTTHLHLERKNNTIKLLQSYVQSLIQRLPPAQRKHHLGIFQKLGSEKSCPLAPAVASTYAPLLLLSQHSNHQEIDNTPQRLLLAAPDGQSYSEKSTTLNLDYSSRKSYLSRLQPPHIANLKSLTLKTLPRVPTDSPQLPSKDKSQETAKKDDRPKLVANEPVTLDTSTPPVAQSLADSKHCSGLHK
SIO_010081: YDL197C
subclass of: SO_0000673
so part of: YDL197C
location: complement(104917..106494)
location: region:104917-106494:-1
so has part: feature:104917-106494:-1:exon

NP_010084.1
type: Protein
SIO_000068: ncbiprotein

S000002356
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:104917-106494:-1:exon

YDL195W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: WEB1
gene: SEC31
locus tag: YDL195W
gene synonym: WEB1
so part of: sequence
location: <107208..>111029
location: region:107208-111029:1
so has part: feature:107208-111029:1:exon
subclass of: SO_0000010

851332
type: Gene
SIO_000068: ncbigene

position:107208:1
position: 107208
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:111029:1
position: 111029
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:107208-111029:1:exon

YDL195W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: WEB1
gene: SEC31
locus tag: YDL195W
gene synonym: WEB1
product: Sec31p
transcript id: NM_001180255.2
SIO_010081: YDL195W
subclass of: SO_0000673
so part of: YDL195W
location: <107208..>111029
location: region:107208-111029:1
so has part: feature:107208-111029:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:107208-111029:1:exon

YDL195W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: WEB1
gene: SEC31
locus tag: YDL195W
gene synonym: WEB1
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:17604721]
experiment: EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0090114 COPII-coated vesicle budding [PMID:8223424]
experiment: EXISTENCE:mutant phenotype:GO:0090114 COPII-coated vesicle budding [PMID:12475940]
note: Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
codon start: 1
product: Sec31p
translation: MVKLAEFSRTATFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDFWNNVSREESKEKPTVFHLQAPTWYGEPSPAAHWAFGGKLVQITPDGKGVSITNPKISGLESNTTLSEALKTKDFKPLINQRLVKVIDDVNEEDWNLLEKLSMDGTEEFLKEALAFDNDESDAQDDANNEKEDDGEEFFQQIETNFQPEGDFSLSGNIEQTISKNLVSGNIKSAVKNSLENDLLMEAMVIALDSNNERLKESVKNAYFAKYGSKSSLSRILYSISKREVDDLVENLDVSQWKFISKAIQNLYPNDIAQRNEMLIKLGDRLKENGHRQDSLTLYLAAGSLDKVASIWLSEFPDLEDKLKKDNKTIYEAHSECLTEFIERFTVFSNFINGSSTINNEQLIAKFLEFINLTTSTGNFELATEFLNSLPSDNEEVKTEKARVLIASGKSLPAQNPATATTSKAKYTNAKTNKNVPVLPTPGMPSTTSIPSMQAPFYGMTPGASANALPPKPYVPATTTSAPVHTEGKYAPPSQPSMASPFVNKTNSSTRLNSFAPPPNPYATATVPATNVSTTSIPQNTFAPIQPGMPIMGDYNAQSSSIPSQPPINAVSGQTPHLNRKANDGWNDLPLKVKEKPSRAKAVSVAPPNILSTPTPLNGIPANAASTMPPPPLSRAPSSVSMVSPPPLHKNSRVPSLVATSESPRASISNPYAPPQSSQQFPIGTISTANQTSNTAQVASSNPYAPPPQQRVATPLSGGVPPAPLPKASNPYAPTATTQPNGSSYPPTGPYTNNHTMTSPPPVFNKPPTGPPPISMKKRSNKLASIEQNPSQGATYPPTLSSSASPLQPSQPPTLASQVNTSAENVSHEIPADQQPIVDFLKEELARVTPLTPKEYSKQLKDCDKRLKILFYHLEKQDLLTQPTIDCLHDLVALMKEKKYKEAMVIHANIATNHAQEGGNWLTGVKRLIGIAEATLN
SIO_010081: YDL195W
subclass of: SO_0000673
so part of: YDL195W
location: 107208..111029
location: region:107208-111029:1
so has part: feature:107208-111029:1:exon

NP_010086.2
type: Protein
SIO_000068: ncbiprotein

S000002354
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:107208-111029:1:exon

YDL194W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNF3
locus tag: YDL194W
so part of: sequence
location: <111580..>114234
location: region:111580-114234:1
so has part: feature:111580-114234:1:exon
subclass of: SO_0000010

851333
type: Gene
SIO_000068: ncbigene

position:111580:1
position: 111580
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:114234:1
position: 114234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111580-114234:1:exon

YDL194W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNF3
locus tag: YDL194W
product: glucose sensor
transcript id: NM_001180254.1
SIO_010081: YDL194W
subclass of: SO_0000673
so part of: YDL194W
location: <111580..>114234
location: region:111580-114234:1
so has part: feature:111580-114234:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111580-114234:1:exon

YDL194W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNF3
locus tag: YDL194W
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2406560|PMID:24124599]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0051594 detection of glucose [PMID:8901598]
experiment: EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:9564039]
experiment: EXISTENCE:mutant phenotype:GO:0015755 fructose transmembrane transport [PMID:2046678]
experiment: EXISTENCE:mutant phenotype:GO:0015761 mannose transmembrane transport [PMID:2046678]
experiment: EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:18616605]
experiment: EXISTENCE:mutant phenotype:GO:0051594 detection of glucose [PMID:8901598]
experiment: EXISTENCE:mutant phenotype:GO:1904659 glucose transmembrane transport [PMID:2046678]
note: Plasma membrane low glucose sensor, regulates glucose transport; high affinity sensor that contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication
codon start: 1
product: glucose sensor
translation: MDPNSNSSSETLRQEKQGFLDKALQRVKGIALRRNNSNKDHTTDDTTGSIRTPTSLQRQNSDRQSNMTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVAVGGFLFGYDTGLINSITSMNYVKSHVAPNHDSFTAQQMSILVSFLSLGTFFGALTAPFISDSYGRKPTIIFSTIFIFSIGNSLQVGAGGITLLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIISTYQWAITWGLLVSSAVSQGTHARNDASSYRIPIGLQYVWSSFLAIGMFFLPESPRYYVLKDKLDEAAKSLSFLRGVPVHDSGLLEELVEIKATYDYEASFGSSNFIDCFISSKSRPKQTLRMFTGIALQAFQQFSGINFIFYYGVNFFNKTGVSNSYLVSFITYAVNVVFNVPGLFFVEFFGRRKVLVVGGVIMTIANFIVAIVGCSLKTVAAAKVMIAFICLFIAAFSATWGGVVWVISAELYPLGVRSKCTAICAAANWLVNFICALITPYIVDTGSHTSSLGAKIFFIWGSLNAMGVIVVYLTVYETKGLTLEEIDELYIKSSTGVVSPKFNKDIRERALKFQYDPLQRLEDGKNTFVAKRNNFDDETPRNDFRNTISGEIDHSPNQKEVHSIPERVDIPTSTEILESPNKSSGMTVPVSPSLQDVPIPQTTEPAEIRTKYVDLGNGLGLNTYNRGPPSLSSDSSEDYTEDEIGGPSSQGDQSNRSTMNDINDYMARLIHSTSTASNTTDKFSGNQSTLRYHTASSHSDTTEEDSNLMDLGNGLALNAYNRGPPSILMNSSDEEANGGETSDNLNTAQDLAGMKERMAQFAQSYIDKRGGLEPETQSNILSTSLSVMADTNEHNNEILHSSEENATNQPVNENNDLK
SIO_010081: YDL194W
subclass of: SO_0000673
so part of: YDL194W
location: 111580..114234
location: region:111580-114234:1
so has part: feature:111580-114234:1:exon

NP_010087.1
type: Protein
SIO_000068: ncbiprotein

S000002353
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111580-114234:1:exon

YDL193W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUS1
locus tag: YDL193W
so part of: sequence
location: <114672..>115799
location: region:114672-115799:1
so has part: feature:114672-115799:1:exon
subclass of: SO_0000010

851334
type: Gene
SIO_000068: ncbigene

position:114672:1
position: 114672
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:115799:1
position: 115799
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:114672-115799:1:exon

YDL193W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUS1
locus tag: YDL193W
product: ditrans,polycis-polyprenyl diphosphate synthase
transcript id: NM_001180253.1
SIO_010081: YDL193W
subclass of: SO_0000673
so part of: YDL193W
location: <114672..>115799
location: region:114672-115799:1
so has part: feature:114672-115799:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:114672-115799:1:exon

YDL193W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUS1
locus tag: YDL193W
EC number: 2.5.1.87
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11086160]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093|PMID:14690591|PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0019408 dolichol biosynthetic process [PMID:25066056]
experiment: EXISTENCE:direct assay:GO:0045547 dehydrodolichyl diphosphate synthase activity [PMID:25066056]
experiment: EXISTENCE:direct assay:GO:1904423 dehydrodolichyl diphosphate synthase complex [PMID:25066056]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:16943325]
note: Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant
codon start: 1
product: ditrans,polycis-polyprenyl diphosphate synthase
translation: MPTMIKKDDKAMEPPNEKPHRKIERDDVPESSNHIPPPESGVLKGGKVNSKTRALKAVTSIIADADENPQKKVNNETNGVQKQKTEDLSKRIGKFEYLFYKFLLVLLYICFGLFRYGQYQYNKMKLRIFSIIYNHAYTPQLIRQDVIPLKKIPKRLAAILEVKPVGDVGGGVTGLLNDASEIVCWTVSAGIKHLMLYDYDGILQRNVPELRMEIHSNLAKYFGPAHVPNYAVKIPHSNKIFYNLDGIETETDVGNEIEANQEKDKIAIEISLLSNRDGRETIVDLTKTMAELCAVNELSVSDITMDLVDSELKQLVGPEPDLLLYFGPSLDLQGFPPWHIRLTEFYWEKDNNEVIYSVFIRGLRQYAGCKVNVGK
SIO_010081: YDL193W
subclass of: SO_0000673
so part of: YDL193W
location: 114672..115799
location: region:114672-115799:1
so has part: feature:114672-115799:1:exon

NP_010088.1
type: Protein
SIO_000068: ncbiprotein

S000002352
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:114672-115799:1:exon

YDL192W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARF1
locus tag: YDL192W
so part of: sequence
location: <116321..>116866
location: region:116321-116866:1
so has part: feature:116321-116866:1:exon
subclass of: SO_0000010

851335
type: Gene
SIO_000068: ncbigene

position:116321:1
position: 116321
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:116866:1
position: 116866
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116321-116866:1:exon

YDL192W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARF1
locus tag: YDL192W
product: Arf family GTPase ARF1
transcript id: NM_001180252.1
SIO_010081: YDL192W
subclass of: SO_0000673
so part of: YDL192W
location: <116321..>116866
location: region:116321-116866:1
so has part: feature:116321-116866:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:116321-116866:1:exon

YDL192W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARF1
locus tag: YDL192W
EC number: 3.6.5.2
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8816753]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:20841378|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9736713|PMID:9813082]
experiment: EXISTENCE:direct assay:GO:1903292 protein localization to Golgi membrane [PMID:33788598]
experiment: EXISTENCE:direct assay:GO:1903358 regulation of Golgi organization [PMID:33788598]
experiment: EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]
experiment: EXISTENCE:physical interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]
note: ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; involved in mitochondrial morphology; ARF1 has a paralog, ARF2, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6
codon start: 1
product: Arf family GTPase ARF1
translation: MGLFASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRHYYRNTEGVIFVVDSNDRSRIGEAREVMQRMLNEDELRNAAWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQATCATSGEGLYEGLEWLSNSLKNST
SIO_010081: YDL192W
subclass of: SO_0000673
so part of: YDL192W
location: 116321..116866
location: region:116321-116866:1
so has part: feature:116321-116866:1:exon

NP_010089.1
type: Protein
SIO_000068: ncbiprotein

S000002351
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116321-116866:1:exon

YDL191W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SOS1
gene: RPL35A
locus tag: YDL191W
gene synonym: SOS1
so part of: sequence
location: <117664..>118517
location: region:117664-118517:1
so has part: feature:117664-118517:1:exon
subclass of: SO_0000010

851336
type: Gene
SIO_000068: ncbigene

position:117664:1
position: 117664
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:118517:1
position: 118517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117664-118517:1:exon

YDL191W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SOS1
gene: RPL35A
locus tag: YDL191W
gene synonym: SOS1
product: ribosomal 60S subunit protein L35A
transcript id: NM_001180196.2
SIO_010081: YDL191W
subclass of: SO_0000673
so part of: YDL191W
location: join(<117664..117666,118158..>118517)
location: region:117664-118517:1
so has part: feature:117664-117666:1:exon
so has part: feature:118158-118517:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:117664-117666:1:exon

position:117666:1
position: 117666
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:118158-118517:1:exon

position:118158:1
position: 118158
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL191W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SOS1
gene: RPL35A
locus tag: YDL191W
gene synonym: SOS1
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:20392820]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:20392820]
note: Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L35A
translation: MAGVKAYELRTKSKEQLASQLVDLKKELAELKVQKLSRPSLPKIKTVRKSIACVLTVINEQQREAVRQLYKGKKYQPKDLRAKKTRALRRALTKFEASQVTEKQRKKQIAFPQRKYAIKA
SIO_010081: YDL191W
subclass of: SO_0000673
so part of: YDL191W
location: join(117664..117666,118158..118517)
location: region:117664-118517:1
so has part: feature:117664-117666:1:exon
so has part: feature:118158-118517:1:exon

NP_010145.1
type: Protein
SIO_000068: ncbiprotein

S000002350
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:117664-117666:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:118158-118517:1:exon

YDL190C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UFD2
locus tag: YDL190C
so part of: sequence
location: complement(<118707..>121592)
location: region:118707-121592:-1
so has part: feature:118707-121592:-1:exon
subclass of: SO_0000010

851337
type: Gene
SIO_000068: ncbigene

position:118707:-1
position: 118707
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:121592:-1
position: 121592
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:118707-121592:-1:exon

YDL190C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UFD2
locus tag: YDL190C
product: ubiquitin-ubiquitin ligase UFD2
transcript id: NM_001180250.2
SIO_010081: YDL190C
subclass of: SO_0000673
so part of: YDL190C
location: complement(<118707..>121592)
location: region:118707-121592:-1
so has part: feature:118707-121592:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:118707-121592:-1:exon

YDL190C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UFD2
locus tag: YDL190C
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15652483|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:10089879]
experiment: EXISTENCE:direct assay:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:10089879]
experiment: EXISTENCE:direct assay:GO:0070936 protein K48-linked ubiquitination [PMID:28165462]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:7615550|PMID:10089879]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:21148305]
experiment: EXISTENCE:mutant phenotype:GO:0031398 positive regulation of protein ubiquitination [PMID:27226596]
note: Ubiquitin (Ub) chain assembly factor (E4); forms branched Ub chains on substrates destined for degradation, catalyzing K48-linked multi-monoubiquitination of K29-linked Ub chains assembled by the Ub-ligase Ufd4p; involved in the Ub-fusion degradation pathway, OLE membrane fluidity pathway, stress response survival and the ERAD pathway for misfolded proteins, where it promotes ubiquitination and transfer of ERAD substrates to Rad23p; U-box family member; homologous to human Ufd2a and Ufd2b
codon start: 1
product: ubiquitin-ubiquitin ligase UFD2
translation: MTAIEDILQITTDPSDTRGYSLLKSEEVPQGSTLGVDFIDTLLLYQLTENEKLDKPFEYLNDCFRRNQQQKRITKNKPNAESLHSTFQEIDRLVIGYGVVALQIENFCMNGAFINYITGIVSNVNSYTDFLSQIIQRAILEGTALDLLNAVFPTLLEYCNKHVSHFDLNESVIYNNVLTIFELFVTFKPIAEIFTKIDGFFADYSCKPQDFERKTILGPILSLSPIEAAVAIRNYGDNLLRSKQQTAMIHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFAHIANKNHLRRADHPPFKELSSNGFMSNITLLLVRFSQPFLDISYKKIDKIDANYFNNPSLFIDLSGETRLNSDFKEADAFYDKNRKTADSKPNFISDCFFLTLTYLHYGLGGTLSFEEKMGSEIKALKEEIEKVKKIAANHDVFARFITAQLSKMEKALKTTESLRFALQGFFAHRSLQLEVFDFICGASTFLIRVVDPEHEFPFKQIKLPLIPDQIGVENVDNADFLRAHAPVPFKYYPEFVVEGPVNYSLYISKYQTSPIFRNPRLGSFVEFTTMVLRCPELVSNPHLKGKLVQLLSVGAMPLTDNSPGFMMDIFEHDELVNKNLLYALLDFYVIVEKTGSSSQFYDKFNSRYSISIILEELYYKIPSYKNQLIWQSQNNADFFVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASASRQAKSSCGLADKSMKLFEIYSKDIPAAFVTPEIVYRLASMLNYNLESLVGPKCGELKVKDPQSYSFNPKDLLKALTTVYINLSEQSEFISAVAKDERSFNRNLFVRAVDILGRKTGLASPEFIEKLLNFANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIDRSTIKAHLLSDSTDPFNRMPLKLEDVTPNEELRQKILCFKKQKKEEAKHKASE
SIO_010081: YDL190C
subclass of: SO_0000673
so part of: YDL190C
location: complement(118707..121592)
location: region:118707-121592:-1
so has part: feature:118707-121592:-1:exon

NP_010091.2
type: Protein
SIO_000068: ncbiprotein

S000002349
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:118707-121592:-1:exon

YDL189W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RBS1
locus tag: YDL189W
so part of: sequence
location: <122216..>123589
location: region:122216-123589:1
so has part: feature:122216-123589:1:exon
subclass of: SO_0000010

851338
type: Gene
SIO_000068: ncbigene

position:122216:1
position: 122216
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:123589:1
position: 123589
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122216-123589:1:exon

YDL189W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RBS1
locus tag: YDL189W
product: Rbs1p
transcript id: NM_001180249.1
SIO_010081: YDL189W
subclass of: SO_0000673
so part of: YDL189W
location: <122216..>123589
location: region:122216-123589:1
so has part: feature:122216-123589:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122216-123589:1:exon

YDL189W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RBS1
locus tag: YDL189W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25605335]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006012 galactose metabolic process [PMID:12372297]
experiment: EXISTENCE:mutant phenotype:GO:1990115 RNA polymerase III assembly [PMID:25605335]
note: Protein involved in assembly of the RNA Pol III complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; physically interacts with Pol III; proposed to bind single-stranded nucleic acids via its R3H domain; capable of forming the prion [VTS1+]
codon start: 1
product: Rbs1p
translation: MTALDSRNWGLTPAMETGLFQKPQDRIFIIELENSIVSFINSNTESFQLRPMNSYYRLLSHQIAEYHNLNHVLARTQDSCVILFKGENFQKIEGKPLLQELQLNKKPEECASSSESIEKSNNNRIFRILKRKEVGNECDYKIDGNTRTPNSNLTANSNKDQKIEIDDKSSTDLEQERIEKERLYEQRKQEIFDKLNKSEDDVKSTNSSGSSDSDNEWSDWLNGDDSNTQTSNGSVSSSSPFNSSVTTIQVNKPQQQFYDSRRGRGGRRRGTNNYKDAYRGQSRRNKENGGYQSGYSSPYLVYPPPQMGGNSLPTYPLMYNPAGPAPGPAPSPMVMGNNTVFMNPYMYNMNPQGSCSFGTPIPMYPPYQYQYQYQYNTQYHSGPYSNTPSYNSNNYTRSSANKYHHFQGKNSYSGAIPKRSDDSNSNKNEGIRRASVEGSPSSRDTDSVEMKFDKLNI
SIO_010081: YDL189W
subclass of: SO_0000673
so part of: YDL189W
location: 122216..123589
location: region:122216-123589:1
so has part: feature:122216-123589:1:exon

NP_010092.2
type: Protein
SIO_000068: ncbiprotein

S000002348
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122216-123589:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS406; Autonomously Replicating Sequence
so part of: sequence
location: 123617..123901
location: region:123617-123901:1
so has part: feature:123617-123901:1:region

S000118429
type: SGD
SIO_000068: sgd

position:123617:1
position: 123617
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:123901:1
position: 123901
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123617-123901:1:region

YDL188C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PPH2
gene: PPH22
locus tag: YDL188C
gene synonym: PPH2
so part of: sequence
location: complement(<123865..>124998)
location: region:123865-124998:-1
so has part: feature:123865-124998:-1:exon
subclass of: SO_0000010

851339
type: Gene
SIO_000068: ncbigene

position:123865:-1
position: 123865
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:124998:-1
position: 124998
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123865-124998:-1:exon

YDL188C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PPH2
gene: PPH22
locus tag: YDL188C
gene synonym: PPH2
product: phosphoprotein phosphatase 2A catalytic subunit PPH22
transcript id: NM_001180248.1
SIO_010081: YDL188C
subclass of: SO_0000673
so part of: YDL188C
location: complement(<123865..>124998)
location: region:123865-124998:-1
so has part: feature:123865-124998:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:123865-124998:-1:exon

YDL188C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PPH2
gene: PPH22
locus tag: YDL188C
gene synonym: PPH2
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:16541024]
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:12135475|PMID:25387524]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]
experiment: EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:12820961]
experiment: EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]
experiment: EXISTENCE:mutant phenotype:GO:2000198 negative regulation of ribonucleoprotein complex localization [PMID:25387524]
experiment: EXISTENCE:physical interaction:GO:0006417 regulation of translation [PMID:10329624]
note: Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
codon start: 1
product: phosphoprotein phosphatase 2A catalytic subunit PPH22
translation: MDMEIDDPMHGSDEDQLSPTLDEDMNSDDGKNNTKARSNDEDTDEELEDFNFKPGSSGIADHKSSKPLKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPTVTRKTPDYFL
SIO_010081: YDL188C
subclass of: SO_0000673
so part of: YDL188C
location: complement(123865..124998)
location: region:123865-124998:-1
so has part: feature:123865-124998:-1:exon

NP_010093.1
type: Protein
SIO_000068: ncbiprotein

S000002347
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:123865-124998:-1:exon

YDL186W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL186W
so part of: sequence
location: <125616..>126449
location: region:125616-126449:1
so has part: feature:125616-126449:1:exon
subclass of: SO_0000010

851340
type: Gene
SIO_000068: ncbigene

position:125616:1
position: 125616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:126449:1
position: 126449
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:125616-126449:1:exon

YDL186W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL186W
product: uncharacterized protein
transcript id: NM_001180246.1
SIO_010081: YDL186W
subclass of: SO_0000673
so part of: YDL186W
location: <125616..>126449
location: region:125616-126449:1
so has part: feature:125616-126449:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:125616-126449:1:exon

YDL186W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL186W
note: hypothetical protein; YDL186W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MQCNTSIEDGLDGGDITFPSYSPEAEAQNRFLPRSEFPSVRQLVISKQKSRRRREENVFVGKMEDVLVKWRPPASSHRGAIEAINGTHPYQLSTAQFNSRRSDPFGSTKRDESVRSIVESFTDWWKRNSKMFFRDEEEGVRTEHSASQDDQELQLFEEDLFSFHLSPNDMSTRNSEHQVQTPVLFPYEAPTRTKQNPAERKVIEIGDGEELSIYRDVYSNPIPVSYLDTLNLNHSMSVRQTQQQQQQRQQQQYVDSSSAFQCCTDSNWARIFFCHHD
SIO_010081: YDL186W
subclass of: SO_0000673
so part of: YDL186W
location: 125616..126449
location: region:125616-126449:1
so has part: feature:125616-126449:1:exon

NP_010095.1
type: Protein
SIO_000068: ncbiprotein

S000002345
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:125616-126449:1:exon

YDL185W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLS8
alternative label: TFP1
gene: VMA1
locus tag: YDL185W
gene synonym: CLS8; TFP1
so part of: sequence
location: <126787..>130002
location: region:126787-130002:1
so has part: feature:126787-130002:1:exon
subclass of: SO_0000010

851342
type: Gene
SIO_000068: ncbigene

position:126787:1
position: 126787
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:130002:1
position: 130002
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:126787-130002:1:exon

YDL185W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLS8
alternative label: TFP1
gene: VMA1
locus tag: YDL185W
gene synonym: CLS8; TFP1
product: H(+)-transporting V1 sector ATPase subunit A
transcript id: NM_001180245.1
SIO_010081: YDL185W
subclass of: SO_0000673
so part of: YDL185W
location: <126787..>130002
location: region:126787-130002:1
so has part: feature:126787-130002:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:126787-130002:1:exon

YDL185W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLS8
alternative label: TFP1
gene: VMA1
locus tag: YDL185W
gene synonym: CLS8; TFP1
EC number: 7.1.2.2
experiment: EXISTENCE:direct assay:GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain [PMID:1530931|PMID:2478556|PMID:8626613]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:7775427|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0019538 protein metabolic process [PMID:8508780]
experiment: EXISTENCE:direct assay:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8718887]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:29519938|PMID:18048916]
note: Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner
codon start: 1
product: H(+)-transporting V1 sector ATPase subunit A
translation: MAGAIENARKEIKRISLEDHAESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKWQFTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSRGTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRVPRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGKTVISQSLSKYSNSDAIIYVGCFAKGTNVLMADGSIECIENIEVGNKVMGKDGRPREVIKLPRGRETMYSVVQKSQHRAHKSDSSREVPELLKFTCNATHELVVRTPRSVRRLSRTIKGVEYFEVITFEMGQKKAPDGRIVELVKEVSKSYPISEGPERANELVESYRKASNKAYFEWTIEARDLSLLGSHVRKATYQTYAPILYENDHFFDYMQKSKFHLTIEGPKVLAYLLGLWIGDGLSDRATFSVDSRDTSLMERVTEYAEKLNLCAEYKDRKEPQVAKTVNLYSKVVRGNGIRNNLNTENPLWDAIVGLGFLKDGVKNIPSFLSTDNIGTRETFLAGLIDSDGYVTDEHGIKATIKTIHTSVRDGLVSLARSLGLVVSVNAEPAKVDMNGTKHKISYAIYMSGGDVLLNVLSKCAGSKKFRPAPAAAFARECRGFYFELQELKEDDYYGITLSDDSDHQFLLANQVVVHNCGERGNEMAEVLMEFPELYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPAGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCPIWKTFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVKHAVSSSKFFEPSRGEKEVHGEFEKLLSTMQERFAESTD
SIO_010081: YDL185W
subclass of: SO_0000673
so part of: YDL185W
location: 126787..130002
location: region:126787-130002:1
so has part: feature:126787-130002:1:exon

NP_010096.1
type: Protein
SIO_000068: ncbiprotein

S000002344
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:126787-130002:1:exon

YDL184C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL47A
gene: RPL41A
locus tag: YDL184C
gene synonym: RPL47A
so part of: sequence
location: complement(<130407..>130484)
location: region:130407-130484:-1
so has part: feature:130407-130484:-1:exon
subclass of: SO_0000010

851344
type: Gene
SIO_000068: ncbigene

position:130407:-1
position: 130407
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:130484:-1
position: 130484
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:130407-130484:-1:exon

YDL184C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL47A
gene: RPL41A
locus tag: YDL184C
gene synonym: RPL47A
product: ribosomal 60S subunit protein L41A
transcript id: NM_001180244.1
SIO_010081: YDL184C
subclass of: SO_0000673
so part of: YDL184C
location: complement(<130407..>130484)
location: region:130407-130484:-1
so has part: feature:130407-130484:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:130407-130484:-1:exon

YDL184C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL47A
gene: RPL41A
locus tag: YDL184C
gene synonym: RPL47A
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
note: Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L41A
translation: MRAKWRKKRTRRLKRKRRKVRARSK
SIO_010081: YDL184C
subclass of: SO_0000673
so part of: YDL184C
location: complement(130407..130484)
location: region:130407-130484:-1
so has part: feature:130407-130484:-1:exon

NP_010097.1
type: Protein
SIO_000068: ncbiprotein

S000002343
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:130407-130484:-1:exon

YDL183C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRX19
locus tag: YDL183C
so part of: sequence
location: complement(<130871..>131833)
location: region:130871-131833:-1
so has part: feature:130871-131833:-1:exon
subclass of: SO_0000010

851345
type: Gene
SIO_000068: ncbigene

position:130871:-1
position: 130871
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:131833:-1
position: 131833
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:130871-131833:-1:exon

YDL183C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRX19
locus tag: YDL183C
product: Mrx19p
transcript id: NM_001180243.1
SIO_010081: YDL183C
subclass of: SO_0000673
so part of: YDL183C
location: complement(<130871..>131833)
location: region:130871-131833:-1
so has part: feature:130871-131833:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:130871-131833:-1:exon

YDL183C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRX19
locus tag: YDL183C
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:20197279]
experiment: EXISTENCE:genetic interaction:GO:0006813 potassium ion transport [PMID:20197279]
experiment: EXISTENCE:genetic interaction:GO:1902600 proton transmembrane transport [PMID:20197279]
note: Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system
codon start: 1
product: Mrx19p
translation: MIRSIFIPPTSITATSRLFYGMRAYSTKLEKASLQKYLHDPVKVTVIPITDKESFIYYKHTDNLFNSQSRILKAEKWIVEKSAKLWRKLKKSPKSYNKKIVSMVQSLLNSTPWSENSLLTIPSESYILKRIKGEKDKTQEIRLTLKDYTVKAEQVDTQPLHVYYPPGISSPDECLRQMKKLYQEGLIYHKKWTLYCLLGLPLTIPLILIPLIPNVPGFYLSYRAYVNIKAYLGAKHLKSLLESSKQNLEFRELLGYTEVYKRGTSSRTQGNQKESKGAPELLLNKKTLPLILDFLEVHELESDLNKVILQESKSQEKNKI
SIO_010081: YDL183C
subclass of: SO_0000673
so part of: YDL183C
location: complement(130871..131833)
location: region:130871-131833:-1
so has part: feature:130871-131833:-1:exon

NP_010098.1
type: Protein
SIO_000068: ncbiprotein

S000002342
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:130871-131833:-1:exon

YDL182W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LYS20
locus tag: YDL182W
so part of: sequence
location: <133437..>134723
location: region:133437-134723:1
so has part: feature:133437-134723:1:exon
subclass of: SO_0000010

851346
type: Gene
SIO_000068: ncbigene

position:133437:1
position: 133437
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:134723:1
position: 134723
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133437-134723:1:exon

YDL182W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LYS20
locus tag: YDL182W
product: homocitrate synthase LYS20
transcript id: NM_001180242.1
SIO_010081: YDL182W
subclass of: SO_0000673
so part of: YDL182W
location: <133437..>134723
location: region:133437-134723:1
so has part: feature:133437-134723:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:133437-134723:1:exon

YDL182W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LYS20
locus tag: YDL182W
EC number: 2.3.3.14
experiment: EXISTENCE:direct assay:GO:0004410 homocitrate synthase activity [PMID:14984204]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9099739|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:25628362]
experiment: EXISTENCE:genetic interaction:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:18524920]
experiment: EXISTENCE:mutant phenotype:GO:0004410 homocitrate synthase activity [PMID:8923736]
note: Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
codon start: 1
product: homocitrate synthase LYS20
translation: MTAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPAAKRTKPSA
SIO_010081: YDL182W
subclass of: SO_0000673
so part of: YDL182W
location: 133437..134723
location: region:133437-134723:1
so has part: feature:133437-134723:1:exon

NP_010099.1
type: Protein
SIO_000068: ncbiprotein

S000002341
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:133437-134723:1:exon

YDL181W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INH1
locus tag: YDL181W
so part of: sequence
location: <135179..>135436
location: region:135179-135436:1
so has part: feature:135179-135436:1:exon
subclass of: SO_0000010

851347
type: Gene
SIO_000068: ncbigene

position:135179:1
position: 135179
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:135436:1
position: 135436
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:135179-135436:1:exon

YDL181W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INH1
locus tag: YDL181W
product: ATPase inhibitor
transcript id: NM_001180241.1
SIO_010081: YDL181W
subclass of: SO_0000673
so part of: YDL181W
location: <135179..>135436
location: region:135179-135436:1
so has part: feature:135179-135436:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:135179-135436:1:exon

YDL181W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INH1
locus tag: YDL181W
experiment: EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:12167646]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12809520|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0032780 negative regulation of ATP-dependent activity [PMID:12809520]
experiment: EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:15294286]
note: Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication
codon start: 1
product: ATPase inhibitor
translation: MLPRSALARSLQLQRGVAARFYSEGSTGTPRGSGSEDSFVKRERATEDFFVRQREKEQLRHLKEQLEKQRKKIDSLENKIDSMTK
SIO_010081: YDL181W
subclass of: SO_0000673
so part of: YDL181W
location: 135179..135436
location: region:135179-135436:1
so has part: feature:135179-135436:1:exon

NP_010100.1
type: Protein
SIO_000068: ncbiprotein

S000002340
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:135179-135436:1:exon

YDL180W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIT1
locus tag: YDL180W
so part of: sequence
location: <135896..>137539
location: region:135896-137539:1
so has part: feature:135896-137539:1:exon
subclass of: SO_0000010

851374
type: Gene
SIO_000068: ncbigene

position:135896:1
position: 135896
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:137539:1
position: 137539
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:135896-137539:1:exon

YDL180W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIT1
locus tag: YDL180W
product: Ait1p
transcript id: NM_001180240.1
SIO_010081: YDL180W
subclass of: SO_0000673
so part of: YDL180W
location: <135896..>137539
location: region:135896-137539:1
so has part: feature:135896-137539:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:135896-137539:1:exon

YDL180W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIT1
locus tag: YDL180W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:36047762|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:36047762]
note: G protein-coupled receptor-like protein; involved in negatively regulating TORC1 activity; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
codon start: 1
product: Ait1p
translation: MVRLNHAASYFMPIFCSTRPHIVILSALFSISLFSLFYASSELLLHQYDDPLMFKPNSQDYFRTFLLGLFSPFLYYFLKTFLFNINQRFLILNLIVDFPINDVFMLLILIGLAYPQVQDHEGGTIKHKECSWHIIPRQAYIFGISWALGEFTICIIGNLFNYQEIADPNINSGFTHQESANTYCNNNDMSHNDDCGCSTEYRPNVVDRSDITLSKCIEVRNDSSSISNNVYSSEYHPIKPLRSSSSTYGSIRQQPHENKKQLHVPDNSQDDTIIMMNPIDNSLKLTTLDTGDLSFPIDEEQPILKKSFGYTWAVPNENTQNTTKSFTPIKRFIAFSTAYQLVTGLLLMILVVGSNIMLTIGESLILSMYFVYVRGHEGLFTPVVNYFGSRTISNFILCVIIPFISLNFLINTSIYLRRELDDWFNNSQGEFEDDDENTISKRVATNQEYQHPLSANYISMDSPDVINSSPGHFGMNSGQLLGNTTLYYGSLNGDDDDMTNDSALLRFCKKLVKNWRALARNDSFVLGVMVSWSLLVFVTGILSTVYI
SIO_010081: YDL180W
subclass of: SO_0000673
so part of: YDL180W
location: 135896..137539
location: region:135896-137539:1
so has part: feature:135896-137539:1:exon

NP_010101.1
type: Protein
SIO_000068: ncbiprotein

S000002339
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:135896-137539:1:exon

YDL179W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PCL9
locus tag: YDL179W
so part of: sequence
location: <138291..>139205
location: region:138291-139205:1
so has part: feature:138291-139205:1:exon
subclass of: SO_0000010

851375
type: Gene
SIO_000068: ncbigene

position:138291:1
position: 138291
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:139205:1
position: 139205
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138291-139205:1:exon

YDL179W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PCL9
locus tag: YDL179W
product: Pcl9p
transcript id: NM_001180239.1
SIO_010081: YDL179W
subclass of: SO_0000673
so part of: YDL179W
location: <138291..>139205
location: region:138291-139205:1
so has part: feature:138291-139205:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:138291-139205:1:exon

YDL179W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PCL9
locus tag: YDL179W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17853895]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17853895]
experiment: EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]
experiment: EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:9593297]
experiment: EXISTENCE:physical interaction:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:19823668]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9593297]
experiment: EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]
note: Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose from the whole genome duplication
codon start: 1
product: Pcl9p
translation: MISDYDALLQFNKKPVSQEMIQFLATSTASIIKIRENNNPIQGCRPPDLSIFIKNVVIQSNVQTPTLMATSVYLNKLKSVIPKNVYGINTTRHRIFLGCLILAAKTLNDSSPWNKHWTTYTEGLLRIREVNTIERELLEYLNWDVRITTPDLIDSLSYFLGPIKEQLFLQRRQEMLLFNAPSPGQLKEYINHRRPVSHSRTSSAISVPSLTSMATVSTTDSRSSLLAKYQPSLPLVESDNFNKKNHVPLRNNNDICNNFRAEENIHSVNHIDVTMGSSPVMSHKPTIHQRLNFTRRGWSSFFKQ
SIO_010081: YDL179W
subclass of: SO_0000673
so part of: YDL179W
location: 138291..139205
location: region:138291-139205:1
so has part: feature:138291-139205:1:exon

NP_010102.1
type: Protein
SIO_000068: ncbiprotein

S000002338
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138291-139205:1:exon

YDL178W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIP2
gene: DLD2
locus tag: YDL178W
gene synonym: AIP2
so part of: sequence
location: <139522..>141114
location: region:139522-141114:1
so has part: feature:139522-141114:1:exon
subclass of: SO_0000010

851376
type: Gene
SIO_000068: ncbigene

position:139522:1
position: 139522
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:141114:1
position: 141114
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:139522-141114:1:exon

YDL178W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIP2
gene: DLD2
locus tag: YDL178W
gene synonym: AIP2
product: D-lactate dehydrogenase
transcript id: NM_001180238.1
SIO_010081: YDL178W
subclass of: SO_0000673
so part of: YDL178W
location: <139522..>141114
location: region:139522-141114:1
so has part: feature:139522-141114:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:139522-141114:1:exon

YDL178W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIP2
gene: DLD2
locus tag: YDL178W
gene synonym: AIP2
EC number: 1.1.2.4
EC number: 1.1.99.40
experiment: EXISTENCE:direct assay:GO:0004458 D-lactate dehydrogenase (cytochrome) activity [PMID:10509019]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10509019]
experiment: EXISTENCE:direct assay:GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity [PMID:26774271]
experiment: EXISTENCE:direct assay:GO:0071949 FAD binding [PMID:26774271]
experiment: EXISTENCE:mutant phenotype:GO:0003779 actin binding [PMID:15158445]
experiment: EXISTENCE:mutant phenotype:GO:1903457 lactate catabolic process [PMID:26774271]
note: D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix
codon start: 1
product: D-lactate dehydrogenase
translation: MLRNILVRSTGSNFKFAGRYMKSSALLGYYRRVNYYSTKIQTRLTSENYPDVHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNEDWMRKYKGQSKLVLRPKSVEKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNKIRDFDPVSGILKCDAGVILENANNYVMEQNYMFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVVMPNGQIVNSMHSMRKDNTGYDLKQLFIGSEGTIGIITGVSILTVPKPKAFNVSYLSVESFEDVQKVFVRARQELSEILSAFEFMDAKSQVLAKSQLKDAAFPLEDEHPFYILIETSGSNKDHDDSKLETFLENVMEEGIVTDGVVAQDETELQNLWKWREMIPEASQANGGVYKYDVSLPLKDLYSLVEATNARLSEAELVGDSPKPVVGAIGYGHVGDGNLHLNVAVREYNKNIEKTLEPFVYEFVSSKHGSVSAEHGLGFQKKNYIGYSKSPEEVKMMKDLKVHYDPNGILNPYKYI
SIO_010081: YDL178W
subclass of: SO_0000673
so part of: YDL178W
location: 139522..141114
location: region:139522-141114:1
so has part: feature:139522-141114:1:exon

NP_010103.1
type: Protein
SIO_000068: ncbiprotein

S000002337
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:139522-141114:1:exon

YDL177C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL177C
so part of: sequence
location: complement(<141209..>141721)
location: region:141209-141721:-1
so has part: feature:141209-141721:-1:exon
subclass of: SO_0000010

851377
type: Gene
SIO_000068: ncbigene

position:141209:-1
position: 141209
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:141721:-1
position: 141721
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141209-141721:-1:exon

YDL177C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL177C
product: uncharacterized protein
transcript id: NM_001180237.1
SIO_010081: YDL177C
subclass of: SO_0000673
so part of: YDL177C
location: complement(<141209..>141721)
location: region:141209-141721:-1
so has part: feature:141209-141721:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141209-141721:-1:exon

YDL177C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL177C
note: hypothetical protein; similar to the mouse IMPACT gene; YDL177C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSKNVGKLVKIWNESEVLVDRKSKFQARCCPLQNQKDIPSILQELTQNNKSVSKASHMHMYAWRTAEVSNNLHLQQEQKKKGNKANKSNNSHVNKSRNITVQPKNIEQGCADCGEAGAGQRLLTLLERANIFNVLVIVTRWYGGTPLGSSRFRHISTCAVETLKKGGFLP
SIO_010081: YDL177C
subclass of: SO_0000673
so part of: YDL177C
location: complement(141209..141721)
location: region:141209-141721:-1
so has part: feature:141209-141721:-1:exon

NP_010104.1
type: Protein
SIO_000068: ncbiprotein

S000002336
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141209-141721:-1:exon

YDL176W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: IPF1
gene: GID12
locus tag: YDL176W
gene synonym: IPF1
so part of: sequence
location: <142097..>144223
location: region:142097-144223:1
so has part: feature:142097-144223:1:exon
subclass of: SO_0000010

851378
type: Gene
SIO_000068: ncbigene

position:142097:1
position: 142097
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:144223:1
position: 144223
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:142097-144223:1:exon

YDL176W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: IPF1
gene: GID12
locus tag: YDL176W
gene synonym: IPF1
product: Gid12p
transcript id: NM_001180236.1
SIO_010081: YDL176W
subclass of: SO_0000673
so part of: YDL176W
location: <142097..>144223
location: region:142097-144223:1
so has part: feature:142097-144223:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:142097-144223:1:exon

YDL176W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: IPF1
gene: GID12
locus tag: YDL176W
gene synonym: IPF1
experiment: EXISTENCE:direct assay:GO:0043254 regulation of protein-containing complex assembly [PMID:35650207]
experiment: EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:32064787]
note: hypothetical protein involved in regulating assembly of Gid4p into the GID E3 ligase complex; interacts with GID complex components; involved in actin patch formation; computationally predicted to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; non-essential gene
codon start: 1
product: Gid12p
translation: MATGRIQFAVSTPCNTKGKPSGYRLFEFKNDRLALVPSERGCTKVDVNANIQAFCYLRPNGRDTSISPDATHILDSCDYMVLAKSNGFIEIISNYQYKIKNGLRLAPSYILRCTPEDFESNFFSDYMIAGLEYSQGLLYCCMCSGRIYVFVMNLPTDYIQYKNMYNPMFPDCFFKVHHDNNTTHSSEEEKLFEGSTRYTGRSCSKHICYFLLPIEPSHLRSSPVVSSFCNMYQGLPIYRPSMYLHIERGISTFHINPLDRFCFMTVSPRSPLFIRKIILPLTYVTFLSTFISLKNSIQGDTCGEILSWDNVAQQNGFGSLFSWISNKFTFDTDIINSTIWDDIVKYSGTGMLDSGIVWKQRQGHAKDDIYELFHTQDMLGSSRRNSSFSTASSEPRPLSRRRRESFQALTRDAFRERMDVPCSTKWELDSFIRGLRRNTFMVDFEIVEKISHRNGNDGVNEDDNTTDESDETMTSFLTDNYKKMDIVCIDHFVTLSAFRPRYYDEPIIKIDSLSNKNGSENGTNEEEWAESQMKVDGQVIDDETAQFKQALGNLCSFKKLFMLDDSLCFILDTHGVLLINRFEIKNTKNLLRNSKDTIRIIPHDFGLINDTIVIINDIDVGTDNVCALTFHLVVTSMAGEITVLKGEFFKNCRLGRIKLCDSLKLNRKDRFVDKLALIDYDGLNAQKRRLDYDEKDLYTFIVKKVKRD
SIO_010081: YDL176W
subclass of: SO_0000673
so part of: YDL176W
location: 142097..144223
location: region:142097-144223:1
so has part: feature:142097-144223:1:exon

NP_010105.1
type: Protein
SIO_000068: ncbiprotein

S000002335
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:142097-144223:1:exon

YDL175C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIR2
locus tag: YDL175C
so part of: sequence
location: complement(<144484..>145518)
location: region:144484-145518:-1
so has part: feature:144484-145518:-1:exon
subclass of: SO_0000010

851379
type: Gene
SIO_000068: ncbigene

position:144484:-1
position: 144484
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145518:-1
position: 145518
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:144484-145518:-1:exon

YDL175C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIR2
locus tag: YDL175C
product: TRAMP complex RNA-binding subunit
transcript id: NM_001180235.1
SIO_010081: YDL175C
subclass of: SO_0000673
so part of: YDL175C
location: complement(<144484..>145518)
location: region:144484-145518:-1
so has part: feature:144484-145518:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:144484-145518:-1:exon

YDL175C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIR2
locus tag: YDL175C
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:22402490]
experiment: EXISTENCE:direct assay:GO:0004652 polynucleotide adenylyltransferase activity [PMID:15935759|PMID:15935758]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]
experiment: EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15828860|PMID:15935758|PMID:15935759]
experiment: EXISTENCE:direct assay:GO:0034458 3'-5' RNA helicase activity [PMID:22532666]
experiment: EXISTENCE:direct assay:GO:0043629 ncRNA polyadenylation [PMID:15828860|PMID:15935758]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:15935758|PMID:17643380]
experiment: EXISTENCE:genetic interaction:GO:0004652 polynucleotide adenylyltransferase activity [PMID:15935759]
experiment: EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]
experiment: EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:18007593]
experiment: EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758]
experiment: EXISTENCE:genetic interaction:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758]
experiment: EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]
experiment: EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:22319136]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:22402490]
note: RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome
codon start: 1
product: TRAMP complex RNA-binding subunit
translation: MEKNTAPFVVDTAPTTPPDKLVAPSIEEVNSNPNELRALRGQGRYFGVSDDDKDAIKEAAPKCNNCSQRGHLKKDCPHIICSYCGATDDHYSRHCPKAIQCSKCDEVGHYRSQCPHKWKKVQCTLCKSKKHSKERCPSIWRAYILVDDNEKAKPKVLPFHTIYCYNCGGKGHFGDDCKEKRSSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSISNSSNYRNYNSYQPYRSGTLGKRR
SIO_010081: YDL175C
subclass of: SO_0000673
so part of: YDL175C
location: complement(144484..145518)
location: region:144484-145518:-1
so has part: feature:144484-145518:-1:exon

NP_010106.1
type: Protein
SIO_000068: ncbiprotein

S000002334
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:144484-145518:-1:exon

YDL174C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DLD1
locus tag: YDL174C
so part of: sequence
location: complement(<145826..>147589)
location: region:145826-147589:-1
so has part: feature:145826-147589:-1:exon
subclass of: SO_0000010

851380
type: Gene
SIO_000068: ncbigene

position:145826:-1
position: 145826
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147589:-1
position: 147589
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145826-147589:-1:exon

YDL174C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DLD1
locus tag: YDL174C
product: D-lactate dehydrogenase
transcript id: NM_001180234.1
SIO_010081: YDL174C
subclass of: SO_0000673
so part of: YDL174C
location: complement(<145826..>147589)
location: region:145826-147589:-1
so has part: feature:145826-147589:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145826-147589:-1:exon

YDL174C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DLD1
locus tag: YDL174C
EC number: 1.1.2.4
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9525904]
experiment: EXISTENCE:mutant phenotype:GO:0004458 D-lactate dehydrogenase (cytochrome) activity [PMID:8492799]
experiment: EXISTENCE:mutant phenotype:GO:1903457 lactate catabolic process [PMID:26774271|PMID:8492799]
note: Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
codon start: 1
product: D-lactate dehydrogenase
translation: MLWKRTCTRLIKPIAQPRGRLVRRSCYRYASTGTGSTDSSSQWLKYSVIASSATLFGYLFAKNLYSRETKEDLIEKLEMVKKIDPVNSTLKLSSLDSPDYLHDPVKIDKVVEDLKQVLGNKPENYSDAKSDLDAHSDTYFNTHHPSPEQRPRIILFPHTTEEVSKILKICHDNNMPVVPFSGGTSLEGHFLPTRIGDTITVDLSKFMNNVVKFDKLDLDITVQAGLPWEDLNDYLSDHGLMFGCDPGPGAQIGGCIANSCSGTNAYRYGTMKENIINMTIVLPDGTIVKTKKRPRKSSAGYNLNGLFVGSEGTLGIVTEATVKCHVKPKAETVAVVSFDTIKDAAACASNLTQSGIHLNAMELLDENMMKLINASESTDRCDWVEKPTMFFKIGGRSPNIVNALVDEVKAVAQLNHCNSFQFAKDDDEKLELWEARKVALWSVLDADKSKDKSAKIWTTDVAVPVSQFDKVIHETKKDMQASKLINAIVGHAGDGNFHAFIVYRTPEEHETCSQLVDRMVKRALNAEGTCTGEHGVGIGKREYLLEELGEAPVDLMRKIKLAIDPKRIMNPDKIFKTDPNEPANDYR
SIO_010081: YDL174C
subclass of: SO_0000673
so part of: YDL174C
location: complement(145826..147589)
location: region:145826-147589:-1
so has part: feature:145826-147589:-1:exon

NP_010107.1
type: Protein
SIO_000068: ncbiprotein

S000002333
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145826-147589:-1:exon

YDL173W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AMU1
gene: PAR32
locus tag: YDL173W
gene synonym: AMU1
so part of: sequence
location: <148191..>149078
location: region:148191-149078:1
so has part: feature:148191-149078:1:exon
subclass of: SO_0000010

851381
type: Gene
SIO_000068: ncbigene

position:148191:1
position: 148191
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:149078:1
position: 149078
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148191-149078:1:exon

YDL173W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AMU1
gene: PAR32
locus tag: YDL173W
gene synonym: AMU1
product: Par32p
transcript id: NM_001180233.1
SIO_010081: YDL173W
subclass of: SO_0000673
so part of: YDL173W
location: <148191..>149078
location: region:148191-149078:1
so has part: feature:148191-149078:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148191-149078:1:exon

YDL173W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AMU1
gene: PAR32
locus tag: YDL173W
gene synonym: AMU1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26172854|PMID:14562095]
note: Low complexity protein; mediates inhibition of Mep1p and Mep3p activity; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylation and localization regulated by TORC1-effector kinase, Npr1p
codon start: 1
product: Par32p
translation: MATFNPQNEMENQARVQEYKVSTGRGGAGNIHKSMSKPSPVLLPLKSNSKTVANNNNNGSNQEKVPRFAIGRGGAGNIFHDPHLTRSAQQLDSNDNINYNDVINDIDDYISPITSDMVDEGGSNPVTNTRSRISATRSHQSLHATTSSPNNNAPIVVGRGGAGNIFFNKKKVASNGGNEEDEIRGGNIEDEDTINANEDNLFVVTSNGNALAAIKSTSKKPKNKLKGKSAPEKFAIGRGGAGNIISPKSSRNTINHNLNDDDEDKFNLKDDNGKEKKKKKKKKSGFFSSLKTMFN
SIO_010081: YDL173W
subclass of: SO_0000673
so part of: YDL173W
location: 148191..149078
location: region:148191-149078:1
so has part: feature:148191-149078:1:exon

NP_010108.1
type: Protein
SIO_000068: ncbiprotein

S000002332
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148191-149078:1:exon

YDL171C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLT1
locus tag: YDL171C
so part of: sequence
location: complement(<149203..>155640)
location: region:149203-155640:-1
so has part: feature:149203-155640:-1:exon
subclass of: SO_0000010

851383
type: Gene
SIO_000068: ncbigene

position:149203:-1
position: 149203
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:155640:-1
position: 155640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:149203-155640:-1:exon

YDL171C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLT1
locus tag: YDL171C
product: glutamate synthase (NADH)
transcript id: NM_001180231.1
SIO_010081: YDL171C
subclass of: SO_0000673
so part of: YDL171C
location: complement(<149203..>155640)
location: region:149203-155640:-1
so has part: feature:149203-155640:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:149203-155640:-1:exon

YDL171C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLT1
locus tag: YDL171C
EC number: 1.4.1.14
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0016040 glutamate synthase (NADH) activity [PMID:7836314]
experiment: EXISTENCE:expression pattern:GO:0006537 glutamate biosynthetic process [PMID:9657994]
experiment: EXISTENCE:expression pattern:GO:0019676 ammonia assimilation cycle [PMID:11356843]
experiment: EXISTENCE:mutant phenotype:GO:0016040 glutamate synthase (NADH) activity [PMID:7836314]
note: NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions
codon start: 1
product: glutamate synthase (NADH)
translation: MPVLKSDNFDPLEEAYEGGTIQNYNDEHHLHKSWANVIPDKRGLYDPDYEHDACGVGFVANKHGEQSHKIVTDARYLLVNMTHRGAVSSDGNGDGAGILLGIPHEFMKREFKLDLDLDIPEMGKYAVGNVFFKKNEKNNKKNLIKCQKIFEDLAASFNLSVLGWRNVPVDSTILGDVALSREPTILQPLLVPLYDEKQPEFNETKFRTQLYLLRKEASLQIGLENWFYVCSLNNTTIVYKGQLTPAQVYNYYPDLTNAHFKSHMALVHSRFSTNTFPSWDRAQPLRWLAHNGEINTLRGNKNWMRSREGVMNSATFKDELDKLYPIIEEGGSDSAALDNVLELLTINGTLSLPEAVMMMVPEAYHKDMDSDLKAWYDWAACLMEPWDGPALLTFTDGRYCGAILDRNGLRPCRYYITSDDRVICASEVGVIPIENSLVVQKGKLKPGDLFLVDTQLGEMVDTKKLKSQISKRQDFKSWLSKVIKLDDLLSKTANLVPKEFISQDSLSLKVQSDPRLLANGYTFEQVTFLLTPMALTGKEALGSMGNDAPLACLNENPVLLYDYFRQLFAQVTNPPIDPIREANVMSLECYVGPQGNLLEMHSSQCDRLLLKSPILHWNEFQALKNIEAAYPSWSVAEIDITFDKSEGLLGYTDTIDKITKLASEAIDDGKKILIITDRKMGANRVSISSLIAISCIHHHLIRNKQRSQVALILETGEAREIHHFCVLLGYGCDGVYPYLAMETLVRMNREGLLRNVNNDNDTLEEGQILENYKHAIDAGILKVMSKMGISTLASYKGAQIFEALGLDNSIVDLCFTGTSSRIRGVTFEYLAQDAFSLHERGYPSRQTISKSVNLPESGEYHFRDGGYKHVNEPTAIASLQDTVRNKNDVSWQLYVKKEMEAIRDCTLRGLLELDFENSVSIPLEQVEPWTEIARRFASGAMSYGSISMEAHSTLAIAMNRLGAKSNCGEGGEDAERSAVQENGDTMRSAIKQVASARFGVTSYYLSDADEIQIKIAQGAKPGEGGELPAHKVSKDIAKTRHSTPNVGLISPPPHHDIYSIEDLKQLIYDLKCANPRAGISVKLVSEVGVGIVASGVAKAKADHILVSGHDGGTGAARWTSVKYAGLPWELGLAETHQTLVLNDLRRNVVVQTDGQLRTGFDIAVAVLLGAESFTLATVPLIAMGCVMLRRCHLNSCAVGIATQDPYLRSKFKGQPEHVINFFYYLIQDLRQIMAKLGFRTIDEMVGHSEKLKKRDDVNAKAINIDLSPILTPAHVIRPGVPTKFTKKQDHKLHTRLDNKLIDEAEVTLDRGLPVNIDASIINTDRALGSTLSYRVSKKFGEDGLPKDTVVVNIEGSAGQSFGAFLASGITFILNGDANDYVGKGLSGGIIVIKPPKDSKFKSDENVIVGNTCFYGATSGTAFISGSAGERFGVRNSGATIVVERIKGNNAFEYMTGGRAIVLSQMESLNAFSGATGGIAYCLTSDYDDFVGKINKDTVELESLCDPVEIAFVKNLIQEHWNYTQSDLAARILGNFNHYLKDFVKVIPTDYKKVLLKEKAEAAKAKAKATSEYLKKFRSNQEVDDEVNTLLIANQKAKEQEKKKSITISNKATLKEPKVVDLEDAVPDSKQLEKNSERIEKTRGFMIHKRRHETHRDPRTRVNDWKEFTNPITKKDAKYQTARCMDCGTPFCLSDTGCPLSNIIPKFNELLFKNQWKLALDKLLETNNFPEFTGRVCPAPCEGACTLGIIEDPVGIKSVERIIIDNAFKEGWIKPCPPSTRTGFTVGVIGSGPAGLACADMLNRAGHTVTVYERSDRCGGLLMYGIPNMKLDKAIVQRRIDLLSAEGIDFVTNTEIGKTISMDELKNKHNAVVYAIGSTIPRDLPIKGRELKNIDFAMQLLESNTKALLNKDLEIIREKIQGKKVIVVGGGDTGNDCLGTSVRHGAASVLNFELLPEPPVERAKDNPWPQWPRVMRVDYGHAEVKEHYGRDPREYCILSKE…
SIO_010081: YDL171C
subclass of: SO_0000673
so part of: YDL171C
location: complement(149203..155640)
location: region:149203-155640:-1
so has part: feature:149203-155640:-1:exon

NP_010110.1
type: Protein
SIO_000068: ncbiprotein

S000002330
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:149203-155640:-1:exon

YDL170W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UGA3
locus tag: YDL170W
so part of: sequence
location: <156318..>157904
location: region:156318-157904:1
so has part: feature:156318-157904:1:exon
subclass of: SO_0000010

851384
type: Gene
SIO_000068: ncbigene

position:156318:1
position: 156318
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157904:1
position: 157904
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:156318-157904:1:exon

YDL170W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UGA3
locus tag: YDL170W
product: Uga3p
transcript id: NM_001180230.1
SIO_010081: YDL170W
subclass of: SO_0000673
so part of: YDL170W
location: <156318..>157904
location: region:156318-157904:1
so has part: feature:156318-157904:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:156318-157904:1:exon

YDL170W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UGA3
locus tag: YDL170W
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12235130]
experiment: EXISTENCE:direct assay:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:21515579]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:21515579]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19159085]
experiment: EXISTENCE:genetic interaction:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:21515579]
experiment: EXISTENCE:mutant phenotype:GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter [PMID:7899074]
experiment: EXISTENCE:mutant phenotype:GO:0009450 gamma-aminobutyric acid catabolic process [PMID:3888627]
experiment: EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:7899074]
note: Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4
codon start: 1
product: Uga3p
translation: MNYGVEKLKLKYSKHGCITCKIRKKRCSEDKPVCRDCRRLSFPCIYISESVDKQSLKKIKADIQHQLISKKRKHAPDSAQKAAVATRTRRVGSDEQDNQVYLSKPLEDCISQKLDSMGLQLYNYYRSHLANIISIAPMNQNYYLNIFLPMAHENDGILFAILAWSANHLSISSSNELRKDEIFVNLANKYTYMSLSHLKTNEGSSACAKLGFLYSLAQILILCGSEICQGDVKFWKILLNIGKNLIENHVGKDVSRILTTTTEEPSLEERIIFPNFNSVVKYWLIVNFIYHDILNFNTTSFPIEQYEKFFQRDQNSLPSSANFIESIDSPIEEIDPLIGINKPILLLLGQVTNLTRFLQTMEQEEMLEHGDKILSLQVEIYKLQPSLMALEHLDDEKKFYYLELFEIMKISTLMFFQLTLLKIDKDSLELQILRNKLDSKLDKVIGTFLEGSLCFPLFIYGVCIQVEDMEKKIDLEAKFDDILKRYKCYNFQNARLLIRKIWQNEADGISEHDLVHMIDELDYNINFA
SIO_010081: YDL170W
subclass of: SO_0000673
so part of: YDL170W
location: 156318..157904
location: region:156318-157904:1
so has part: feature:156318-157904:1:exon

NP_010111.1
type: Protein
SIO_000068: ncbiprotein

S000002329
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:156318-157904:1:exon

YDL169C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UGX2
locus tag: YDL169C
so part of: sequence
location: complement(<158064..>158735)
location: region:158064-158735:-1
so has part: feature:158064-158735:-1:exon
subclass of: SO_0000010

851385
type: Gene
SIO_000068: ncbigene

position:158064:-1
position: 158064
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:158735:-1
position: 158735
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:158064-158735:-1:exon

YDL169C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UGX2
locus tag: YDL169C
product: Ugx2p
transcript id: NM_001180229.1
SIO_010081: YDL169C
subclass of: SO_0000673
so part of: YDL169C
location: complement(<158064..>158735)
location: region:158064-158735:-1
so has part: feature:158064-158735:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:158064-158735:-1:exon

YDL169C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UGX2
locus tag: YDL169C
note: hypothetical protein; transcript accumulates in response to any combination of stress conditions
codon start: 1
product: Ugx2p
translation: MEDKEKLIVYSNTSSVFTYSAEIRPNFKISVSQSQGFAWNQDLFATQYQQSYKVVYDAHEDNFDELILKIKGKLKTKSNKRAKMKSKTKLTRTAKQRRESPVCERDESDEDNDSDHYQRIQVLDGHEFPRANRYKSVWAHDVHSNEDSTSDGESNHDIDMIGGTGTSYAGAAIMDRPRRKSERSISFVEDSKTGDYRYQTGQVDVVEVDSDTPENNHLKWLIK
SIO_010081: YDL169C
subclass of: SO_0000673
so part of: YDL169C
location: complement(158064..158735)
location: region:158064-158735:-1
so has part: feature:158064-158735:-1:exon

NP_010112.1
type: Protein
SIO_000068: ncbiprotein

S000002328
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:158064-158735:-1:exon

YDL168W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ADH5
gene: SFA1
locus tag: YDL168W
gene synonym: ADH5
so part of: sequence
location: <159604..>160764
location: region:159604-160764:1
so has part: feature:159604-160764:1:exon
subclass of: SO_0000010

851386
type: Gene
SIO_000068: ncbigene

position:159604:1
position: 159604
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:160764:1
position: 160764
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159604-160764:1:exon

YDL168W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ADH5
gene: SFA1
locus tag: YDL168W
gene synonym: ADH5
product: bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
transcript id: NM_001180228.1
SIO_010081: YDL168W
subclass of: SO_0000673
so part of: YDL168W
location: <159604..>160764
location: region:159604-160764:1
so has part: feature:159604-160764:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159604-160764:1:exon

YDL168W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ADH5
gene: SFA1
locus tag: YDL168W
gene synonym: ADH5
EC number: 1.1.1.1
EC number: 1.1.1.284
experiment: EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:8483449]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0046294 formaldehyde catabolic process [PMID:8483449]
experiment: EXISTENCE:direct assay:GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity [PMID:8483449]
experiment: EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]
experiment: EXISTENCE:mutant phenotype:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:12499363]
experiment: EXISTENCE:mutant phenotype:GO:0033833 hydroxymethylfurfural reductase (NADH) activity [PMID:16652391]
experiment: EXISTENCE:mutant phenotype:GO:0033859 furaldehyde metabolic process [PMID:16652391]
note: Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress
codon start: 1
product: bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
translation: MSAATVGKPIKCIAAVAYDAKKPLSVEEITVDAPKAHEVRIKIEYTAVCHTDAYTLSGSDPEGLFPCVLGHEGAGIVESVGDDVITVKPGDHVIALYTAECGKCKFCTSGKTNLCGAVRATQGKGVMPDGTTRFHNAKGEDIYHFMGCSTFSEYTVVADVSVVAIDPKAPLDAACLLGCGVTTGFGAALKTANVQKGDTVAVFGCGTVGLSVIQGAKLRGASKIIAIDINNKKKQYCSQFGATDFVNPKEDLAKDQTIVEKLIEMTDGGLDFTFDCTGNTKIMRDALEACHKGWGQSIIIGVAAAGEEISTRPFQLVTGRVWKGSAFGGIKGRSEMGGLIKDYQKGALKVEEFITHRRPFKEINQAFEDLHNGDCLRTVLKSDEIK
SIO_010081: YDL168W
subclass of: SO_0000673
so part of: YDL168W
location: 159604..160764
location: region:159604-160764:1
so has part: feature:159604-160764:1:exon

NP_010113.1
type: Protein
SIO_000068: ncbiprotein

S000002327
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159604-160764:1:exon

YDL167C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NRP1
locus tag: YDL167C
so part of: sequence
location: complement(<160995..>163154)
location: region:160995-163154:-1
so has part: feature:160995-163154:-1:exon
subclass of: SO_0000010

851387
type: Gene
SIO_000068: ncbigene

position:160995:-1
position: 160995
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:163154:-1
position: 163154
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160995-163154:-1:exon

YDL167C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NRP1
locus tag: YDL167C
product: Nrp1p
transcript id: NM_001180227.1
SIO_010081: YDL167C
subclass of: SO_0000673
so part of: YDL167C
location: complement(<160995..>163154)
location: region:160995-163154:-1
so has part: feature:160995-163154:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160995-163154:-1:exon

YDL167C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NRP1
locus tag: YDL167C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]
note: Putative RNA binding hypothetical protein; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
codon start: 1
product: Nrp1p
translation: MHYVVLELQVAHLPDTPKDQCRIANIAFQIVNAETLVCHYGTNSLPSIEVNGTTKSLESAMVQLDKDIHDVIGNDDFVLVSLYSTWHIRVTLPRQARDDGFILTSYLQHPKVFDLWKEFDRWCVNHPEILGQKKAISNNNCNTKSISINAAKNTKDLDEIVRILEVSIPTEEAGSVPEIYSLLKRTTDILIQLHKKCTSPEDMESVLTKPYDSHTDIRAFLQEKSKILYMNNLPPDTTQSELESWFTQYGVRPVGFWTVKNIVEDTSNVNNNWSLNNSPYVEDQDSISGFVVFQTHEEATEVLALNGRSILSNLANTKQPRVVEHVLELQPSSTGVLDKAQEILSPFPQSKNKPRPGDWNCPSCGFSNFQRRTACFRCSFPAPSNSQIHTANSNNNVNSSRNNLNNRVNSGSSSNISNTAANHPYGAPEFNMIANNTPAALTYNRAHFPAITPLSRQNSLNMAPSNSGSPIIIADHFSGNNNIAPNYRYNNNINNNNNNINNMTNNRYNINNNINGNGNGNGNNSNNNNNHNNNHNNNHHNGSINSNSNTNNNNNNNNGNNSNNCNSNIGMGGCGSNMPFRAGDWKCSTCTYHNFAKNVVCLRCGGPKSISGDASETNHYIDSSTFGPASRTPSNNNISVNTNGGSNAGRTDGNDNKGRDISLMEFMSPPLSMATKSMKEGDGNGSSFNEFKSDKANVNFSNVGDNSAFGNGFNSSIRW
SIO_010081: YDL167C
subclass of: SO_0000673
so part of: YDL167C
location: complement(160995..163154)
location: region:160995-163154:-1
so has part: feature:160995-163154:-1:exon

NP_010114.1
type: Protein
SIO_000068: ncbiprotein

S000002326
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160995-163154:-1:exon

YDL166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAP7
locus tag: YDL166C
so part of: sequence
location: complement(<163449..>164042)
location: region:163449-164042:-1
so has part: feature:163449-164042:-1:exon
subclass of: SO_0000010

851388
type: Gene
SIO_000068: ncbigene

position:163449:-1
position: 163449
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164042:-1
position: 164042
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:163449-164042:-1:exon

YDL166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAP7
locus tag: YDL166C
product: nucleoside-triphosphatase
transcript id: NM_001180226.1
SIO_010081: YDL166C
subclass of: SO_0000673
so part of: YDL166C
location: complement(<163449..>164042)
location: region:163449-164042:-1
so has part: feature:163449-164042:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:163449-164042:-1:exon

YDL166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAP7
locus tag: YDL166C
EC number: 2.7.4.3
experiment: EXISTENCE:direct assay:GO:0004017 adenylate kinase activity [PMID:24823650]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10692169]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:24823650]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16287850|PMID:12837249]
experiment: EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:16287850]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10692169]
note: Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p; complex with Rps14 is conserved between humans, yeast, and arches; may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; human TAF9 functionally complements the lethality of the null mutation
codon start: 1
product: nucleoside-triphosphatase
translation: MEARRYGPNIIVTGTPGCGKSSTCEFLKNKLKDYKYYNISDFAKDNDCFEGYDEGRKSHIVDEDKLLDMLEPLLRQGNSIVDWHVNDVFPERLIDLVVVLRCDNSNLYSRLHARGYHDSKIEENLDAEIMGVVKQDAVESYEPHIVVELQSDTKEDMVSNVSRIVAWEKMWLEQHPDGVTNEYQGPRSDDEDDEDSE
SIO_010081: YDL166C
subclass of: SO_0000673
so part of: YDL166C
location: complement(163449..164042)
location: region:163449-164042:-1
so has part: feature:163449-164042:-1:exon

NP_010115.1
type: Protein
SIO_000068: ncbiprotein

S000002325
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:163449-164042:-1:exon

YDL165W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DNA19
alternative label: NOT2
gene: CDC36
locus tag: YDL165W
gene synonym: DNA19; NOT2
so part of: sequence
location: <164290..>164865
location: region:164290-164865:1
so has part: feature:164290-164865:1:exon
subclass of: SO_0000010

851389
type: Gene
SIO_000068: ncbigene

position:164290:1
position: 164290
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164865:1
position: 164865
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164290-164865:1:exon

YDL165W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DNA19
alternative label: NOT2
gene: CDC36
locus tag: YDL165W
gene synonym: DNA19; NOT2
product: CCR4-NOT core subunit CDC36
transcript id: NM_001180225.1
SIO_010081: YDL165W
subclass of: SO_0000673
so part of: YDL165W
location: <164290..>164865
location: region:164290-164865:1
so has part: feature:164290-164865:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164290-164865:1:exon

YDL165W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DNA19
alternative label: NOT2
gene: CDC36
locus tag: YDL165W
gene synonym: DNA19; NOT2
experiment: EXISTENCE:direct assay:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]
experiment: EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7926748]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]
experiment: EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]
experiment: EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:26952104]
experiment: EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:2111445]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11404327]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16926149]
experiment: EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15706350]
experiment: EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:2111445]
experiment: EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]
note: Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor
codon start: 1
product: CCR4-NOT core subunit CDC36
translation: MEKFGLKALVPLLKLEDKELSSTYDHSMTLGADLSSMLYSLGIPRDSQDHRVLDTFQSPWAETSRSEVEPRFFTPESFTNIPGVLQSTVTPPCFNSIQNDQQRVALFQDETLFFLFYKHPGTVIQELTYLELRKRNWRYHKTLKAWLTKDPMMEPIVSADGLSERGSYVFFDPQRWEKCQRDFLLFYNAIM
SIO_010081: YDL165W
subclass of: SO_0000673
so part of: YDL165W
location: 164290..164865
location: region:164290-164865:1
so has part: feature:164290-164865:1:exon

NP_010116.1
type: Protein
SIO_000068: ncbiprotein

S000002324
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164290-164865:1:exon

YDL164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MMS8
gene: CDC9
locus tag: YDL164C
gene synonym: MMS8
so part of: sequence
location: complement(<164987..>167254)
location: region:164987-167254:-1
so has part: feature:164987-167254:-1:exon
subclass of: SO_0000010

851391
type: Gene
SIO_000068: ncbigene

position:164987:-1
position: 164987
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167254:-1
position: 167254
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164987-167254:-1:exon

YDL164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MMS8
gene: CDC9
locus tag: YDL164C
gene synonym: MMS8
product: DNA ligase (ATP) CDC9
transcript id: NM_001180224.1
SIO_010081: YDL164C
subclass of: SO_0000673
so part of: YDL164C
location: complement(<164987..>167254)
location: region:164987-167254:-1
so has part: feature:164987-167254:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164987-167254:-1:exon

YDL164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MMS8
gene: CDC9
locus tag: YDL164C
gene synonym: MMS8
EC number: 6.5.1.1
experiment: EXISTENCE:direct assay:GO:0003910 DNA ligase (ATP) activity [PMID:1445910|PMID:6347688]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10531002]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10531002|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006266 DNA ligation [PMID:9759502]
experiment: EXISTENCE:direct assay:GO:0006273 lagging strand elongation [PMID:9759502]
experiment: EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:6749599]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10531002]
experiment: EXISTENCE:mutant phenotype:GO:0006266 DNA ligation [PMID:9759502]
experiment: EXISTENCE:mutant phenotype:GO:0006273 lagging strand elongation [PMID:9759502]
experiment: EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:10052932]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:10052932]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:9230305]
experiment: EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]
note: DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature
codon start: 1
product: DNA ligase (ATP) CDC9
translation: MRRLLTGCLLSSARPLKSRLPLLMSSSLPSSAGKKPKQATLARFFTSMKNKPTEGTPSPKKSSKHMLEDRMDNVSGEEEYATKKLKQTAVTHTVAAPSSMGSNFSSIPSSAPSSGVADSPQQSQRLVGEVEDALSSNNNDHYSSNIPYSEVCEVFNKIEAISSRLEIIRICSDFFIKIMKQSSKNLIPTTYLFINRLGPDYEAGLELGLGENLLMKTISETCGKSMSQIKLKYKDIGDLGEIAMGARNVQPTMFKPKPLTVGEVFKNLRAIAKTQGKDSQLKKMKLIKRMLTACKGIEAKFLIRSLESKLRIGLAEKTVLISLSKALLLHDENREDSPDKDVPMDVLESAQQKIRDAFCQVPNYEIVINSCLEHGIMNLDKYCTLRPGIPLKPMLAKPTKAINEVLDRFQGETFTSEYKYDGERAQVHLLNDGTMRIYSRNGENMTERYPEINITDFIQDLDTTKNLILDCEAVAWDKDQGKILPFQVLSTRKRKDVELNDVKVKVCLFAFDILCYNDERLINKSLKERREYLTKVTKVVPGEFQYATQITTNNLDELQKFLDESVNHSCEGLMVKMLEGPESHYEPSKRSRNWLKLKKDYLEGVGDSLDLCVLGAYYGRGKRTGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQLLHDRLTPTIIDGPKATFVFDSSAEPDVWFEPTTLFEVLTADLSLSPIYKAGSATFDKGVSLRFPRFLRIREDKGVEDATSSDQIVELYENQSHMQN
SIO_010081: YDL164C
subclass of: SO_0000673
so part of: YDL164C
location: complement(164987..167254)
location: region:164987-167254:-1
so has part: feature:164987-167254:-1:exon

NP_010117.1
type: Protein
SIO_000068: ncbiprotein

S000002323
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164987-167254:-1:exon

YDL161W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENT1
locus tag: YDL161W
so part of: sequence
location: <167714..>169078
location: region:167714-169078:1
so has part: feature:167714-169078:1:exon
subclass of: SO_0000010

851392
type: Gene
SIO_000068: ncbigene

position:167714:1
position: 167714
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:169078:1
position: 169078
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167714-169078:1:exon

YDL161W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENT1
locus tag: YDL161W
product: epsin
transcript id: NM_001180221.1
SIO_010081: YDL161W
subclass of: SO_0000673
so part of: YDL161W
location: <167714..>169078
location: region:167714-169078:1
so has part: feature:167714-169078:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167714-169078:1:exon

YDL161W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENT1
locus tag: YDL161W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005769 early endosome [PMID:10449404]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:10449404]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12529323]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:10449404]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:31370222]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10449404]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10449404]
note: Epsin-like protein involved in endocytosis and actin patch assembly; K63-specific Ub chain binding protein that functions as an endocytic adaptor; binds clathrin via a clathrin-binding domain motif at C-terminus; contains two ubiquitin-interacting motifs (UIMs); functionally redundant with Ent2p; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication
codon start: 1
product: epsin
translation: MSKQFVRSAKNLVKGYSSTQVLVRNATSNDNHQVSKDSLIELAEKSYDSADFFEIMDMLDKRLNDKGKYWRHIAKALTVIDYLIRFGSENCVLWCRENLYIIKTLKEFRHEDDEGIDQGQIVRVKAKELTALLSDDERLNEERNMNIKGRNRKGRRRRGTGRSDENDDDLQRAISASRLTAEEDERRRKQDEDYETALQLSKEEEELKRLQDLQRMQQQQGQQQLQQPMYYDIFGNPITPEEYAQFQLQQQQQQQQQQLQQQPMYYDVFGNPITPEELAQFQQQQQLQEQQYLASMQQQQQAMSNNPFAKSEQSSSSPKRNQLVAASSPQQLQQQKQQEPLIQNRTGNQSMTDKYSKLNELLATGTGIDTFGNVGEARIPAQHTKTGTFINSQGTGYRQVSDDPNHNPFLNSQYTGLPSTSVVPTQTGYGFGNQSQQQSQNNGSNNRGYTLIDL
SIO_010081: YDL161W
subclass of: SO_0000673
so part of: YDL161W
location: 167714..169078
location: region:167714-169078:1
so has part: feature:167714-169078:1:exon

NP_010120.1
type: Protein
SIO_000068: ncbiprotein

S000002320
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167714-169078:1:exon

YDL160C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MHF2
locus tag: YDL160C-A
so part of: sequence
location: complement(<169366..>169608)
location: region:169366-169608:-1
so has part: feature:169366-169608:-1:exon
subclass of: SO_0000010

1466431
type: Gene
SIO_000068: ncbigene

position:169366:-1
position: 169366
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:169608:-1
position: 169608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:169366-169608:-1:exon

YDL160C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MHF2
locus tag: YDL160C-A
product: Mhf2p
transcript id: NM_001184530.1
SIO_010081: YDL160C-A
subclass of: SO_0000673
so part of: YDL160C-A
location: complement(<169366..>169608)
location: region:169366-169608:-1
so has part: feature:169366-169608:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:169366-169608:-1:exon

YDL160C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MHF2
locus tag: YDL160C-A
experiment: EXISTENCE:direct assay:GO:0071821 FANCM-MHF complex [PMID:22325783]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:20347428]
note: Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
codon start: 1
product: Mhf2p
translation: MLSKEALIKILSQNEGGNDMKIADEVVPMIQKYLDIFIDEAVLRSLQSHKDINGERGDKSPLELSHQDLERIVGLLLMDM
SIO_010081: YDL160C-A
subclass of: SO_0000673
so part of: YDL160C-A
location: complement(169366..169608)
location: region:169366-169608:-1
so has part: feature:169366-169608:-1:exon

NP_878060.1
type: Protein
SIO_000068: ncbiprotein

S000028520
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:169366-169608:-1:exon

YDL160C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DHH1
locus tag: YDL160C
so part of: sequence
location: complement(<170410..>171930)
location: region:170410-171930:-1
so has part: feature:170410-171930:-1:exon
subclass of: SO_0000010

851394
type: Gene
SIO_000068: ncbigene

position:170410:-1
position: 170410
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:171930:-1
position: 171930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:170410-171930:-1:exon

YDL160C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DHH1
locus tag: YDL160C
product: DExD/H-box ATP-dependent RNA helicase DHH1
transcript id: NM_001180220.1
SIO_010081: YDL160C
subclass of: SO_0000673
so part of: YDL160C
location: complement(<170410..>171930)
location: region:170410-171930:-1
so has part: feature:170410-171930:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:170410-171930:-1:exon

YDL160C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DHH1
locus tag: YDL160C
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:12730603|PMID:18611963|PMID:20368989]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:12032091]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:20368989|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:27692063]
experiment: EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]
experiment: EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:18981231]
experiment: EXISTENCE:genetic interaction:GO:0045900 negative regulation of translational elongation [PMID:22719226]
experiment: EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:11780629]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:32989641]
experiment: EXISTENCE:mutant phenotype:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:27692063]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:32989641]
experiment: EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:21844211]
experiment: EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:18182159]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231|PMID:20368989]
experiment: EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:32989641]
experiment: EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:17041186|PMID:18182159|PMID:30973873]
experiment: EXISTENCE:mutant phenotype:GO:0045900 negative regulation of translational elongation [PMID:22719226]
note: Cytoplasmic DEAD-box helicase and mRNA decapping activator; interacts with decapping and deadenylase complexes to coordinate mRNA decapping and decay; regulates general translational repression; translational activator of select mRNAs during filamentous growth, mating and autophagy; cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body assembly, while ATPase stimulation by Not1p promotes disassembly; forms cytoplasmic foci on replication stress
codon start: 1
product: DExD/H-box ATP-dependent RNA helicase DHH1
translation: MGSINNNFNTNNNSNTDLDRDWKTALNIPKKDTRPQTDDVLNTKGNTFEDFYLKRELLMGIFEAGFEKPSPIQEEAIPVAITGRDILARAKNGTGKTAAFVIPTLEKVKPKLNKIQALIMVPTRELALQTSQVVRTLGKHCGISCMVTTGGTNLRDDILRLNETVHILVGTPGRVLDLASRKVADLSDCSLFIMDEADKMLSRDFKTIIEQILSFLPPTHQSLLFSATFPLTVKEFMVKHLHKPYEINLMEELTLKGITQYYAFVEERQKLHCLNTLFSKLQINQAIIFCNSTNRVELLAKKITDLGYSCYYSHARMKQQERNKVFHEFRQGKVRTLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAINLINWNDRFNLYKIEQELGTEIAAIPATIDKSLYVAENDETVPVPFPIEQQSYHQQAIPQQQLPSQQQFAIPPQQHHPQFMVPPSHQQQQAYPPPQMPSQQGYPPQQEHFMAMPPGQSQPQY
SIO_010081: YDL160C
subclass of: SO_0000673
so part of: YDL160C
location: complement(170410..171930)
location: region:170410-171930:-1
so has part: feature:170410-171930:-1:exon

NP_010121.1
type: Protein
SIO_000068: ncbiprotein

S000002319
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:170410-171930:-1:exon

YDL159W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YDL159W-B
locus tag: YDL159W-A
gene synonym: YDL159W-B
so part of: sequence
location: <172182..>172313
location: region:172182-172313:1
so has part: feature:172182-172313:1:exon
subclass of: SO_0000010

851395
type: Gene
SIO_000068: ncbigene

position:172182:1
position: 172182
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:172313:1
position: 172313
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:172182-172313:1:exon

YDL159W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YDL159W-B
locus tag: YDL159W-A
gene synonym: YDL159W-B
product: uncharacterized protein
transcript id: NM_001184465.1
SIO_010081: YDL159W-A
subclass of: SO_0000673
so part of: YDL159W-A
location: <172182..>172313
location: region:172182-172313:1
so has part: feature:172182-172313:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:172182-172313:1:exon

YDL159W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YDL159W-B
locus tag: YDL159W-A
gene synonym: YDL159W-B
note: hypothetical protein; identified by sequence comparison with hemiascomycetous yeast species
codon start: 1
product: uncharacterized protein
translation: MYNQIINTFIDDCLFLQTPMLQSPISSKIVLSFFLRNFFPSLF
SIO_010081: YDL159W-A
subclass of: SO_0000673
so part of: YDL159W-A
location: 172182..172313
location: region:172182-172313:1
so has part: feature:172182-172313:1:exon

NP_076884.1
type: Protein
SIO_000068: ncbiprotein

S000007599
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:172182-172313:1:exon

YDL159W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STE7
locus tag: YDL159W
so part of: sequence
location: <172481..>174028
location: region:172481-174028:1
so has part: feature:172481-174028:1:exon
subclass of: SO_0000010

851396
type: Gene
SIO_000068: ncbigene

position:172481:1
position: 172481
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:174028:1
position: 174028
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:172481-174028:1:exon

YDL159W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STE7
locus tag: YDL159W
product: mitogen-activated protein kinase kinase STE7
transcript id: NM_001180219.1
SIO_010081: YDL159W
subclass of: SO_0000673
so part of: YDL159W
location: <172481..>174028
location: region:172481-174028:1
so has part: feature:172481-174028:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:172481-174028:1:exon

YDL159W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STE7
locus tag: YDL159W
EC number: 2.7.12.2
experiment: EXISTENCE:direct assay:GO:0004708 MAP kinase kinase activity [PMID:8668180|PMID:8384702]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11781566]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11781566|PMID:17952059]
experiment: EXISTENCE:direct assay:GO:0071507 pheromone response MAPK cascade [PMID:8159759|PMID:8455599|PMID:8384702]
experiment: EXISTENCE:genetic interaction:GO:0000196 cell wall integrity MAPK cascade [PMID:10880465]
experiment: EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:9363895]
experiment: EXISTENCE:genetic interaction:GO:0071507 pheromone response MAPK cascade [PMID:8455599]
experiment: EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:15456892]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8643578]
experiment: EXISTENCE:mutant phenotype:GO:0010525 regulation of transposition, RNA-mediated [PMID:9566871]
experiment: EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:8159759|PMID:8384702]
experiment: EXISTENCE:physical interaction:GO:0071507 pheromone response MAPK cascade [PMID:8668180]
note: Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway
codon start: 1
product: mitogen-activated protein kinase kinase STE7
translation: MFQRKTLQRRNLKGLNLNLHPDVGNNGQLQEKTETHQGQSRIEGHVMSNINAIQNNSNLFLRRGIKKKLTLDAFGDDQAISKPNTVVIQQPQNEPVLVLSSLSQSPCVSSSSSLSTPCIIDAYSNNFGLSPSSTNSTPSTIQGLSNIATPVENEHSISLPPLEESLSPAAADLKDTLSGTSNGNYIQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKFRHWCRKIKSKIKEDKRIKREALDRAKLEKKQSERSTH
SIO_010081: YDL159W
subclass of: SO_0000673
so part of: YDL159W
location: 172481..174028
location: region:172481-174028:1
so has part: feature:172481-174028:1:exon

NP_010122.1
type: Protein
SIO_000068: ncbiprotein

S000002318
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:172481-174028:1:exon

YDL157C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DMO2
locus tag: YDL157C
so part of: sequence
location: complement(<174232..>174588)
location: region:174232-174588:-1
so has part: feature:174232-174588:-1:exon
subclass of: SO_0000010

851398
type: Gene
SIO_000068: ncbigene

position:174232:-1
position: 174232
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:174588:-1
position: 174588
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:174232-174588:-1:exon

YDL157C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DMO2
locus tag: YDL157C
product: Dmo2p
transcript id: NM_001180217.1
SIO_010081: YDL157C
subclass of: SO_0000673
so part of: YDL157C
location: complement(<174232..>174588)
location: region:174232-174588:-1
so has part: feature:174232-174588:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:174232-174588:-1:exon

YDL157C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DMO2
locus tag: YDL157C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
note: hypothetical protein; localizes to the ER and peroxisomes; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Dmo2p
translation: MSNILAVFNPPPQRELEKEETMDCVPCQVMSTMFSVGFGSYLASGKPFKYGKKEAKRGISLTEFEKRNPQWWKVTLRSFGGLLIAFGFVRGTEGWLWHKNKEYKNYKKLSNDGETQAN
SIO_010081: YDL157C
subclass of: SO_0000673
so part of: YDL157C
location: complement(174232..174588)
location: region:174232-174588:-1
so has part: feature:174232-174588:-1:exon

NP_010124.1
type: Protein
SIO_000068: ncbiprotein

S000002316
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:174232-174588:-1:exon

YDL156W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CMR1
locus tag: YDL156W
so part of: sequence
location: <174918..>176486
location: region:174918-176486:1
so has part: feature:174918-176486:1:exon
subclass of: SO_0000010

851399
type: Gene
SIO_000068: ncbigene

position:174918:1
position: 174918
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:176486:1
position: 176486
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:174918-176486:1:exon

YDL156W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CMR1
locus tag: YDL156W
product: Cmr1p
transcript id: NM_001180216.1
SIO_010081: YDL156W
subclass of: SO_0000673
so part of: YDL156W
location: <174918..>176486
location: region:174918-176486:1
so has part: feature:174918-176486:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:174918-176486:1:exon

YDL156W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CMR1
locus tag: YDL156W
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:22367945]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:22367945]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22367945|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:mutant phenotype:GO:2000001 regulation of DNA damage checkpoint [PMID:25817432]
note: Nuclear protein with role in transcription, protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; also localizes to coding regions of transcribed genes; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions
codon start: 1
product: Cmr1p
translation: MPELTEFQKKRLENIKRNNDLLKKLHLSGVASQIKHEAGVLEKSRAPAKKKQKTTNTRATKSASPTLPTRRSRRLRGESADDVKGIPNVNDNQLLKMGSPDGQDKNFIDAIKEKPVIGDVKLSDLIKDEDESALLEKFKRFNNGNFSSGDFFEEIKKRQGDVTGMDEFDLDLYDVFQPNEIKITYERISATYFHPAMEKKLIIAGDTSGTVGFWNVRDEPLADSEEDRMEEPDITRVKLFTKNVGRIDCFPADTSKILLTSYDGSIRSVHLNNLQSEEVLTLKNEYDDSLGISDCQFSYENPNVLFLTTLGGEFTTFDTRVKKSEYNLRRLADKKIGSMAINPMRPYEIATGSLDRTLKIWDTRNLVKKPEWSQYEDYPSHEIVSTYDSRLSVSAVSYSPTDGTLVCNGYDDTIRLFDVKSRDHLSAKLEPKLTIQHNCQTGRWTSILKARFKPNKNVFAIANMKRAIDIYNSEGQQLAHLPTATVPAVISWHPLRNWIAGGNSSGKIFLFTDDSGTIKQEE
SIO_010081: YDL156W
subclass of: SO_0000673
so part of: YDL156W
location: 174918..176486
location: region:174918-176486:1
so has part: feature:174918-176486:1:exon

NP_010125.1
type: Protein
SIO_000068: ncbiprotein

S000002315
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:174918-176486:1:exon

YDL155W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CLB3
locus tag: YDL155W
so part of: sequence
location: <176773..>178056
location: region:176773-178056:1
so has part: feature:176773-178056:1:exon
subclass of: SO_0000010

851400
type: Gene
SIO_000068: ncbigene

position:176773:1
position: 176773
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:178056:1
position: 178056
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:176773-178056:1:exon

YDL155W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CLB3
locus tag: YDL155W
product: B-type cyclin CLB3
transcript id: NM_001180215.1
SIO_010081: YDL155W
subclass of: SO_0000673
so part of: YDL155W
location: <176773..>178056
location: region:176773-178056:1
so has part: feature:176773-178056:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:176773-178056:1:exon

YDL155W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CLB3
locus tag: YDL155W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12972503|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:32553169]
experiment: EXISTENCE:direct assay:GO:0007135 meiosis II [PMID:18423199]
experiment: EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:11438663|PMID:1387566|PMID:16688214]
experiment: EXISTENCE:genetic interaction:GO:1901673 regulation of mitotic spindle assembly [PMID:8319908]
experiment: EXISTENCE:mutant phenotype:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:8388545|PMID:8455600]
experiment: EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:1427070]
experiment: EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8388545|PMID:8455600]
note: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication
codon start: 1
product: B-type cyclin CLB3
translation: MHHNSQSLSSGHIRSPEDENVAPIGNLKHRTGSLSHISSAHPRVALSDVTNIVATNSSNNSISKPKVAPIKERLDSAAIIEEERLDANSVAQRKEADHNDLLTDREQEEPVEDDGESEEDEEEDQEPLLLQHYASDTLVWEHAFRTYYRTTLDPNDDDVYDVVMVAELSNEIFEYMRKLEDLYKPNPYYMDKQPELRWSFRSTLIDWIVQVHEKFQLLPETLYLCINIIDRYLCKEVVPVNKFQLVGAASLFIAAKYEEINCPTIKDFVYMSENCYSRNDLLDAERTILNGLEFELGWPGPMSFLRRISKADDYEHDTRTLAKYLLESTIMDHRLVSAQPSWLAAGAYFLSKIILGQNQWSLAHVYYSNYTQEQILPLATIILENCRYASKRHNAIWRKYSSRRYLHSSQIVAKWIALAEHRVERSN
SIO_010081: YDL155W
subclass of: SO_0000673
so part of: YDL155W
location: 176773..178056
location: region:176773-178056:1
so has part: feature:176773-178056:1:exon

NP_010126.1
type: Protein
SIO_000068: ncbiprotein

S000002314
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:176773-178056:1:exon

YDL154W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSH5
locus tag: YDL154W
so part of: sequence
location: <178334..>181039
location: region:178334-181039:1
so has part: feature:178334-181039:1:exon
subclass of: SO_0000010

851401
type: Gene
SIO_000068: ncbigene

position:178334:1
position: 178334
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:181039:1
position: 181039
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:178334-181039:1:exon

YDL154W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSH5
locus tag: YDL154W
product: MutS family protein MSH5
transcript id: NM_001180214.1
SIO_010081: YDL154W
subclass of: SO_0000673
so part of: YDL154W
location: <178334..>181039
location: region:178334-181039:1
so has part: feature:178334-181039:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:178334-181039:1:exon

YDL154W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSH5
locus tag: YDL154W
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:8001134]
experiment: EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:30467025]
experiment: EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:30467025]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:30467025]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0062037 D-loop DNA binding [PMID:30467025]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:8001134|PMID:15066280|PMID:9374523]
experiment: EXISTENCE:physical interaction:GO:0062128 MutSgamma complex [PMID:9374523]
note: Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
codon start: 1
product: MutS family protein MSH5
translation: MSHEWLISASETMRSIGNGEGLRDKGAVVANNDGEFNEGDTNREEDSSTIFSFDFDEEIVMCIDFSGGKLGCSILDYHTKTLKAFDQDYVVNKTTISSHDLIDDADMSSNDISLLLGLLIMEANPTVCLVPARLEDWIFDYIKTKCDEINCRLELQPIKRFKKWDLLQSLQLRGHDNQTILNDILSNSKFTTTVTLGTVGCILANHEQLGEYNDSTASSNMVTGRLVQNAFEDVIHGIRYIDIRDRMVLDENTISALHIFPTAHKLGHDKMMRNGFFSVFELFNQVSSDYARRILKSWLINPLTNKKRIETRYSIIRTLLDKQNAIIFSDLSQSIKRCPDAFGFINQLRSGKSTLGTWSKVASFLEKGIAIFQLVSSLKLGSDEANILHDIKNKVDISALKECLRKVETVIDFDTSRDTKTLTINTGVDNRLDECRNIYNHLEGILLDVARETQIFLLNTMPQEDCKTTKSLEKLVNAVYIPQLGYLVTISVLMEPLLDGIPNLQWEEIFRSSENIYFKNGRVLELDETYGDIYGAISDFEIEILFSLQEQILRRKTQLTAYNILLSELEILLSFAQVSAERNYAEPQLVEDECILEIINGRHALYETFLDNYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGANASGKSVYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQMAKSLSLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNENVLTENIKGIKHYCTDILISQKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCAKVCGLSRDIVERAEELSRMINRGDDVVQQCGNLTEKEMREFQKNQEIVKKFLSWDLDLETTTTSENLRLKLKNFLR
SIO_010081: YDL154W
subclass of: SO_0000673
so part of: YDL154W
location: 178334..181039
location: region:178334-181039:1
so has part: feature:178334-181039:1:exon

NP_010127.1
type: Protein
SIO_000068: ncbiprotein

S000002313
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:178334-181039:1:exon

YDL153C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UTP3
gene: SAS10
locus tag: YDL153C
gene synonym: UTP3
so part of: sequence
location: complement(<181186..>183018)
location: region:181186-183018:-1
so has part: feature:181186-183018:-1:exon
subclass of: SO_0000010

851403
type: Gene
SIO_000068: ncbigene

position:181186:-1
position: 181186
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:183018:-1
position: 183018
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:181186-183018:-1:exon

YDL153C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UTP3
gene: SAS10
locus tag: YDL153C
gene synonym: UTP3
product: rRNA-processing protein SAS10
transcript id: NM_001180213.1
SIO_010081: YDL153C
subclass of: SO_0000673
so part of: YDL153C
location: complement(<181186..>183018)
location: region:181186-183018:-1
so has part: feature:181186-183018:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:181186-183018:-1:exon

YDL153C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UTP3
gene: SAS10
locus tag: YDL153C
gene synonym: UTP3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9611201]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309|PMID:12837249]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
note: Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene
codon start: 1
product: rRNA-processing protein SAS10
translation: MVRKGSNRTKTSEVGDEINPYGLNEVDDFASKREKVLLGQSTFGDSNKDDDHSLLEDEDEEEVLAMDEDDESIDEREDEEEEEEEELDGAAAYKKIFGRNLETDQLPEEDEENGMLDNENAWGSTKGEYYGADDLDDDEAAKEIEKEALRQQKKHLEELNMNDYLDEEEEEEWVKSAKEFDMGEFKNSTKQADTKTSITDILNMDDEARDNYLRTMFPEFAPLSKEFTELAPKFDELKKSEENEFNKLKLIALGSYLGTISCYYSILLHELHNNEDFTSMKGHPVMEKILTTKEIWRQASELPSSFDVNEGDGSESEETANIEAFNEKKLNELQNSEDSDAEDGGKQKQEIDEEERESDEEEEEEDVDIDDFEEYVAQSRLHSKPKTSSMPEADDFIESEIADVDAQDKKARRRTLRFYTSKIDQQENKKTDRFKGDDDIPYKERLFERQQRLLDEARKRGMHDNNGADLDDKDYGSEDEAVSRSINTQGENDYYQQVQRGKQDKKISRKEAHKNAVIAAREGKLAELAENVSGDGKRAINYQILKNKGLTPKRNKDNRNSRVKKRKKYQKAQKKLKSVRAVYSGGQSGVYEGEKTGIKKGLTRSVKFKN
SIO_010081: YDL153C
subclass of: SO_0000673
so part of: YDL153C
location: complement(181186..183018)
location: region:181186-183018:-1
so has part: feature:181186-183018:-1:exon

NP_010128.1
type: Protein
SIO_000068: ncbiprotein

S000002312
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:181186-183018:-1:exon

YDL150W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPC4
gene: RPC53
locus tag: YDL150W
gene synonym: RPC4
so part of: sequence
location: <183343..>184611
location: region:183343-184611:1
so has part: feature:183343-184611:1:exon
subclass of: SO_0000010

851404
type: Gene
SIO_000068: ncbigene

position:183343:1
position: 183343
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184611:1
position: 184611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:183343-184611:1:exon

YDL150W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPC4
gene: RPC53
locus tag: YDL150W
gene synonym: RPC4
product: DNA-directed RNA polymerase III subunit C53
transcript id: NM_001180210.1
SIO_010081: YDL150W
subclass of: SO_0000673
so part of: YDL150W
location: <183343..>184611
location: region:183343-184611:1
so has part: feature:183343-184611:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:183343-184611:1:exon

YDL150W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPC4
gene: RPC53
locus tag: YDL150W
gene synonym: RPC4
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
experiment: EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1406624]
note: RNA polymerase III subunit C53
codon start: 1
product: DNA-directed RNA polymerase III subunit C53
translation: MSSNKGNGRLPSLKDSSSNGGGSAKPSLKFKPKAVARKSKEEREAAASKVKLEEESKRGNDKKHFNNKNKRVTGAGGQQRRMAKYLNNTHVISSGPLAAGNFVSEKGDLRRGFIKSEGSGSSLVQKGLETIDNGAESSENEAEDDDNEGVASKSKKKFNMGKEFEARNLIEDEDDGESEKSSDVDMDDEEWRSKRIEQLFPVRPVRVRHEDVETVKREIQEALSEKPTREPTPSVKTEPVGTGLQSYLEERERQVNEKLADLGLEKEFQSVDGKEAAAELELLNADHQHILRKLKKMNNKPERFMVFQLPTRLPAFERPAVKEEKEDMETQASDPSKKKKNIKKKDTKDALSTRELAGKVGSIRVHKSGKLSVKIGNVVMDIGKGAETTFLQDVIALSIADDASSAELLGRVDGKIVVTPQI
SIO_010081: YDL150W
subclass of: SO_0000673
so part of: YDL150W
location: 183343..184611
location: region:183343-184611:1
so has part: feature:183343-184611:1:exon

NP_010131.1
type: Protein
SIO_000068: ncbiprotein

S000002309
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:183343-184611:1:exon

YDL149W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG9
alternative label: AUT9
alternative label: CVT6
alternative label: CVT7
gene: ATG9
locus tag: YDL149W
gene synonym: APG9; AUT9; CVT6; CVT7
so part of: sequence
location: <184925..>187918
location: region:184925-187918:1
so has part: feature:184925-187918:1:exon
subclass of: SO_0000010

851406
type: Gene
SIO_000068: ncbigene

position:184925:1
position: 184925
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:187918:1
position: 187918
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184925-187918:1:exon

YDL149W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG9
alternative label: AUT9
alternative label: CVT6
alternative label: CVT7
gene: ATG9
locus tag: YDL149W
gene synonym: APG9; AUT9; CVT6; CVT7
product: autophagy protein ATG9
transcript id: NM_001180209.1
SIO_010081: YDL149W
subclass of: SO_0000673
so part of: YDL149W
location: <184925..>187918
location: region:184925-187918:1
so has part: feature:184925-187918:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184925-187918:1:exon

YDL149W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG9
alternative label: AUT9
alternative label: CVT6
alternative label: CVT7
gene: ATG9
locus tag: YDL149W
gene synonym: APG9; AUT9; CVT6; CVT7
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:16874040|PMID:18497569|PMID:23129774]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16874040]
experiment: EXISTENCE:direct assay:GO:0030659 cytoplasmic vesicle membrane [PMID:23129774]
experiment: EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]
experiment: EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:10662773|PMID:23129774|PMID:24881874]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:10662773]
experiment: EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:23129774]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]
note: Lipid scramblase that mediates autophagosomal membrane expansion; translocates phospholipids between outer and inner leaflets of liposomes; transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between phagophore assembly site (PAS) and other cytosolic punctate structures
codon start: 1
product: autophagy protein ATG9
translation: MERDEYQLPNSHGKNTFLSRIFGLQSDEVNPSLNSQEMSNFPLPDIERGSSLLHSTNDSREDVDENDLRVPESDQGTSTEEEDEVDEEQVQAYAPQISDGLDGDHQLNSVTSKENVLETEKSNLERLVEGSTDDSVPKVGQLSSEEEEDNEFINNDGFDDDTPLFQKSKIHEFSSKKSNTIEDGKRPLFFRHILQNNRPQRDTQKLFTSSNAIHHDKDKSANNGPRNINGNQKHGTKYFGSATQPRFTGSPLNNTNRFTKLFPLRKPNLLSNISVLNNTPEDRINTLSVKERALWKWANVENLDIFLQDVYNYYLGNGFYCIILEKILNICTLLFVVFVSTYMGHCVDYSKLPTSHRVSDIIIDKCYSNSITGFTKFFLWMFYFFVILKIVQLYFDVQKLSELQNFYKYLLNISDDELQTLPWQNVIQQLMYLKDQNAMTANVVEVKAKNRIDAHDVANRIMRRENYLIALYNSDILNLSLPIPLFRTNVLTKTLEWNINLCVMGFVFNESGFIKQSILKPSQREFTREELQKRFMLAGFLNIILAPFLVTYFVLLYFFRYFNEYKTSPGSIGARQYTPIAEWKFREYNELYHIFKKRISLSTTLANKYVDQFPKEKTNLFLKFVSFICGSFVAILAFLTVFDPENFLNFEITSDRSVIFYITILGAIWSVSRNTITQEYHVFDPEETLKELYEYTHYLPKEWEGRYHKEEIKLEFCKLYNLRIVILLRELTSLMITPFVLWFSLPSSAGRIVDFFRENSEYVDGLGYVCKYAMFNMKNIDGEDTHSMDEDSLTKKIAVNGSHTLNSKRRSKFTAEDHSDKDLANNKMLQSYVYFMDDYSNSENLTGKYQLPAKKGYPNNEGDSFLNNKYSWRKQFQPGQKPELFRIGKHALGPGHNISPAIYSTRNPGKNWDNNNNGDDIKNGTNNATAKNDDNNGNNDHEYVLTESFLDSGAFPNHDVIDHNKMLNSNYNGNGILNKGGVLGLVKEYYKKSDVGR
SIO_010081: YDL149W
subclass of: SO_0000673
so part of: YDL149W
location: 184925..187918
location: region:184925-187918:1
so has part: feature:184925-187918:1:exon

NP_010132.1
type: Protein
SIO_000068: ncbiprotein

S000002308
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184925-187918:1:exon

YDL148C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UTP2
gene: NOP14
locus tag: YDL148C
gene synonym: UTP2
so part of: sequence
location: complement(<188154..>190586)
location: region:188154-190586:-1
so has part: feature:188154-190586:-1:exon
subclass of: SO_0000010

851407
type: Gene
SIO_000068: ncbigene

position:188154:-1
position: 188154
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:190586:-1
position: 190586
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:188154-190586:-1:exon

YDL148C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UTP2
gene: NOP14
locus tag: YDL148C
gene synonym: UTP2
product: snoRNA-binding rRNA-processing protein NOP14
transcript id: NM_001180208.1
SIO_010081: YDL148C
subclass of: SO_0000673
so part of: YDL148C
location: complement(<188154..>190586)
location: region:188154-190586:-1
so has part: feature:188154-190586:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:188154-190586:-1:exon

YDL148C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UTP2
gene: NOP14
locus tag: YDL148C
gene synonym: UTP2
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:12068309|PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:15167894]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11694595]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:11694595]
experiment: EXISTENCE:physical interaction:GO:0030692 Noc4p-Nop14p complex [PMID:12446671]
note: Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
codon start: 1
product: snoRNA-binding rRNA-processing protein NOP14
translation: MAGSQLKNLKAALKARGLTGQTNVKSKNKKNSKRQAKEYDREEKKKAIAEIREEFNPFEIKAARNKRRDGLPSKTADRIAVGKPGISKQIGEEQRKRAFEARKMMKNKRGGVIDKRFGERDKLLTEEEKMLERFTRERQSQSKRNANLFNLEDDEDDGDMFGDGLTHLGQSLSLEDELANDEEDFLASKRFNEDDAELQQPQRKKTKAEVMKEVIAKSKFYKQERQKAQGIMEDQIDNLDDNFEDVMSELMMTQPKKNPMEPKTDLDKEYDIKVKELQLDKRAAPSDRTKTEEEKNAEAEEKKRELEQQRLDRMNGMIELEEGEERGVEDLDDGFWENEEDYEDDNDGIADSDDDIKFEDQGRDEGFSQILKKKNISISCPRTHDALLDQVKKLDLDDHPKIVKNIIKAYQPKLAEGNKEKLGKFTAVLLRHIIFLSNQNYLKNVQSFKRTQNALISILKSLSEKYNRELSEECRDYINEMQARYKKNHFDALSNGDLVFFSIIGILFSTSDQYHLVITPALILMSQFLEQIKFNSLKRIAFGAVLVRIVSQYQRISKRYIPEVVYFFQKILLTFIVEKENQEKPLDFENIRLDSYELGLPLDVDFTKKRSTIIPLHTLSTMDTEAHPVDQCVSVLLNVMESLDATISTVWKSLPAFNEIILPIQQLLSAYTSKYSDFEKPRNILNKVEKLTKFTEHIPLALQNHKPVSIPTHAPKYEENFNPDKKSYDPDRTRSEINKMKAQLKKERKFTMKEIRKDAKFEARQRIEEKNKESSDYHAKMAHIVNTINTEEGAEKNKYERERKLRGGKK
SIO_010081: YDL148C
subclass of: SO_0000673
so part of: YDL148C
location: complement(188154..190586)
location: region:188154-190586:-1
so has part: feature:188154-190586:-1:exon

NP_010133.1
type: Protein
SIO_000068: ncbiprotein

S000002307
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:188154-190586:-1:exon

YDL147W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAS5
gene: RPN5
locus tag: YDL147W
gene synonym: NAS5
so part of: sequence
location: <190924..>192261
location: region:190924-192261:1
so has part: feature:190924-192261:1:exon
subclass of: SO_0000010

851408
type: Gene
SIO_000068: ncbigene

position:190924:1
position: 190924
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:192261:1
position: 192261
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:190924-192261:1:exon

YDL147W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAS5
gene: RPN5
locus tag: YDL147W
gene synonym: NAS5
product: proteasome regulatory particle lid subunit RPN5
transcript id: NM_001180207.1
SIO_010081: YDL147W
subclass of: SO_0000673
so part of: YDL147W
location: <190924..>192261
location: region:190924-192261:1
so has part: feature:190924-192261:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:190924-192261:1:exon

YDL147W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAS5
gene: RPN5
locus tag: YDL147W
gene synonym: NAS5
experiment: EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:21289098]
experiment: EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:21289098]
experiment: EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:11742986|PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:21289098]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27226596]
note: Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN
codon start: 1
product: proteasome regulatory particle lid subunit RPN5
translation: MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLAKIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIETIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFILEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQYLQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLIHKIQNDNNLKKLESQESLVKLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRITLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVDELLEHIETIGHLITKEEIMHGLQAK
SIO_010081: YDL147W
subclass of: SO_0000673
so part of: YDL147W
location: 190924..192261
location: region:190924-192261:1
so has part: feature:190924-192261:1:exon

NP_010134.1
type: Protein
SIO_000068: ncbiprotein

S000002306
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:190924-192261:1:exon

YDL146W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LDB17
locus tag: YDL146W
so part of: sequence
location: <192750..>194225
location: region:192750-194225:1
so has part: feature:192750-194225:1:exon
subclass of: SO_0000010

851409
type: Gene
SIO_000068: ncbigene

position:192750:1
position: 192750
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194225:1
position: 194225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:192750-194225:1:exon

YDL146W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LDB17
locus tag: YDL146W
product: Ldb17p
transcript id: NM_001180206.1
SIO_010081: YDL146W
subclass of: SO_0000673
so part of: YDL146W
location: <192750..>194225
location: region:192750-194225:1
so has part: feature:192750-194225:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:192750-194225:1:exon

YDL146W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LDB17
locus tag: YDL146W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:19506040]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:19506040]
note: Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
codon start: 1
product: Ldb17p
translation: MILDPLSPNIENHTQDEIIEFWEKTESIANIPKENLDESHVNSSLVAYLKFATDSYKVFINTDRDLYRMSLILLESSLFEFKKEFCLSKLQSLLNIDLLEMNMKFIIVYILLCEAKKNVYSLEIMLKFQGFTVFYNTLYTQFAYLSKYGKERTVASKHQYNSNNSSTGTSLDSLDRSLTDIDLGIIDEMKQISTVLMDLLFQIMKYCKCVIANLQIVDDFFVYYMMESMRSDTMDDMFNNAEFKLLLALNEQYMMFAKEYDIENKVYKYLINGSVSRCFTELLLLKFNRASDPPLQIMMCKIIYLILTPRGDYSPMNFFYTNDLRVLIDVLIRELQNISEDEEVLRNTLLRVLIPLLKNTQLSKTHYRKDDLNKLLNYLSTLDNICVDSPALHEHQVTVALSRKCLQQIPWLETPSTPSDGGSSVSSNNTSRNSSIVALGTPDNQNILARKGHLYSNRELDVSAESLTKRKAKAPPPPPPPPPSRKCGTPK
SIO_010081: YDL146W
subclass of: SO_0000673
so part of: YDL146W
location: 192750..194225
location: region:192750-194225:1
so has part: feature:192750-194225:1:exon

NP_010135.1
type: Protein
SIO_000068: ncbiprotein

S000002305
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:192750-194225:1:exon

YDL145C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RET1
alternative label: SEC33
alternative label: SOO1
gene: COP1
locus tag: YDL145C
gene synonym: RET1; SEC33; SOO1
so part of: sequence
location: complement(<194571..>198176)
location: region:194571-198176:-1
so has part: feature:194571-198176:-1:exon
subclass of: SO_0000010

851410
type: Gene
SIO_000068: ncbigene

position:194571:-1
position: 194571
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:198176:-1
position: 198176
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:194571-198176:-1:exon

YDL145C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RET1
alternative label: SEC33
alternative label: SOO1
gene: COP1
locus tag: YDL145C
gene synonym: RET1; SEC33; SOO1
product: coatomer subunit alpha
transcript id: NM_001180205.1
SIO_010081: YDL145C
subclass of: SO_0000673
so part of: YDL145C
location: complement(<194571..>198176)
location: region:194571-198176:-1
so has part: feature:194571-198176:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:194571-198176:-1:exon

YDL145C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RET1
alternative label: SEC33
alternative label: SOO1
gene: COP1
locus tag: YDL145C
gene synonym: RET1; SEC33; SOO1
experiment: EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9427388]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:27068463]
experiment: EXISTENCE:mutant phenotype:GO:0030126 COPI vesicle coat [PMID:8001155]
note: Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway
codon start: 1
product: coatomer subunit alpha
translation: MKMLTKFESKSTRAKGIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPIFVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIACLTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLDGSLGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVIFHPHQNLIISVGEDKTLRVWDLDKRTPVKQFKRENDRFWLIAAHPHINLFGAAHDSGIMVFKLDRERPCSFIHQNQLFFVNAEKQIQSFNFQKRVASLPYASLKGIGQPWDAFRSISYNPSQHSVLVNEANGKFALVILPKQPVGAVEPTSVTQDTGNFATFVGRNRFVVYNKNTESVEVRSLENKVTRNIKVEETVRTIVAAGPGSVLVIHPREVILYDVQQGKKVSQLAVKNVKYVSWSLDGQYVALMSKHTITLATKKLELINSMHETIRIKSAAWDETGVLIYSTLNHIRYSLLNGDRGIIKTLEKTLYITKVQGKLVYCLNREGEIEILTIDPTEYRFKKALVNKNFPEVLRLIKDSNLVGQNIISYLQKSGYPEIALQFVQDPHIRFDLALEYGNLDVALDEAKKLNDSSTWERLIQEALAQGNASLAEMIYQTQHSFDKLSFLYLVTGDVNKLSKMQNIAQTREDFGSMLLNTFYNNSTKERSSIFAEGGSLPLAYAVAKANGDEAAASAFLEQAEVDEQDVTLPDQMDASNFVQRPVISKPLEKWPLKEAELSYFEKAVLGQIDDLTIDDETPAVNTTQEQEEPLGEENFNDEDIGEDEGAWDLGDEDLDVGEELPEEVEQGEITSPAQEVETAIWIKNSKLPAVLVAAGAFDAAVQALSKQVGVVKLEPLKKYFTNIYEGCRTYIPSTPCELPAQLGYVRAYDDTVSEDQILPYVPGLDVVNEKMNEGYKNFKLNKPDIAIECFREAIYRITLLMVDDAEDEKLAHKILETAREYILGLSIELERRSLKEGNTVRMLELAAYFTKAKLSPIHRTNALQVAMSQHFKHKNFLQASYFAGEFLKIISSGPRAEQARKIKNKADSMASDAIPIDFDPYAKFDICAATYKPIYEDTPSVSDPLTGSKYVITEKDKIDRIAMISKIGAPASGLRIRV
SIO_010081: YDL145C
subclass of: SO_0000673
so part of: YDL145C
location: complement(194571..198176)
location: region:194571-198176:-1
so has part: feature:194571-198176:-1:exon

NP_010136.1
type: Protein
SIO_000068: ncbiprotein

S000002304
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:194571-198176:-1:exon

YDL144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL144C
so part of: sequence
location: complement(<198662..>199732)
location: region:198662-199732:-1
so has part: feature:198662-199732:-1:exon
subclass of: SO_0000010

851411
type: Gene
SIO_000068: ncbigene

position:198662:-1
position: 198662
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:199732:-1
position: 199732
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198662-199732:-1:exon

YDL144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL144C
product: uncharacterized protein
transcript id: NM_001180204.1
SIO_010081: YDL144C
subclass of: SO_0000673
so part of: YDL144C
location: complement(<198662..>199732)
location: region:198662-199732:-1
so has part: feature:198662-199732:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:198662-199732:-1:exon

YDL144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL144C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MSRILVIGAGGVGVITALSLWLKKESDVSLVVRSDYDRVLKHGYTIESCDYGRLEGWRPHHIYSSVEDAASAADNQGYNYIVVTTKNIIDGPVNSRVSNIIRPVLEKNKELHGPQLTTHILLVQNGIDIEKEIWAEFPREQYRYTVLSGIQLIGSTKIGSGHISQVGQDHLSCGAFDPQDAAAIQAANDFVRMYSNEGQNFVEFDPRVRYSRWKKLLYNAAINTSTALVGLDVPRCLEFGVNKKSTEIEVFHPAMREIIAIAASEGIIIEEEFITMFTEITRKKVFKPSMCVDCEKGQLMELEVILGNPIRIAKRNGVATPTLSILYNLLVLVQAKLKERKGLLKFDEKTATLVDE
SIO_010081: YDL144C
subclass of: SO_0000673
so part of: YDL144C
location: complement(198662..199732)
location: region:198662-199732:-1
so has part: feature:198662-199732:-1:exon

NP_010137.2
type: Protein
SIO_000068: ncbiprotein

S000002303
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198662-199732:-1:exon

YDL143W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ANC2
alternative label: TCP4
gene: CCT4
locus tag: YDL143W
gene synonym: ANC2; TCP4
so part of: sequence
location: <199996..>201582
location: region:199996-201582:1
so has part: feature:199996-201582:1:exon
subclass of: SO_0000010

851412
type: Gene
SIO_000068: ncbigene

position:199996:1
position: 199996
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201582:1
position: 201582
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:199996-201582:1:exon

YDL143W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ANC2
alternative label: TCP4
gene: CCT4
locus tag: YDL143W
gene synonym: ANC2; TCP4
product: chaperonin-containing T-complex subunit CCT4
transcript id: NM_001180203.1
SIO_010081: YDL143W
subclass of: SO_0000673
so part of: YDL143W
location: <199996..>201582
location: region:199996-201582:1
so has part: feature:199996-201582:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:199996-201582:1:exon

YDL143W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ANC2
alternative label: TCP4
gene: CCT4
locus tag: YDL143W
gene synonym: ANC2; TCP4
experiment: EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]
experiment: EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]
note: Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo
codon start: 1
product: chaperonin-containing T-complex subunit CCT4
translation: MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR
SIO_010081: YDL143W
subclass of: SO_0000673
so part of: YDL143W
location: 199996..201582
location: region:199996-201582:1
so has part: feature:199996-201582:1:exon

NP_010138.1
type: Protein
SIO_000068: ncbiprotein

S000002302
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:199996-201582:1:exon

YDL142C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLS1
gene: CRD1
locus tag: YDL142C
gene synonym: CLS1
so part of: sequence
location: complement(<201719..>202570)
location: region:201719-202570:-1
so has part: feature:201719-202570:-1:exon
subclass of: SO_0000010

851413
type: Gene
SIO_000068: ncbigene

position:201719:-1
position: 201719
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:202570:-1
position: 202570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:201719-202570:-1:exon

YDL142C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLS1
gene: CRD1
locus tag: YDL142C
gene synonym: CLS1
product: cardiolipin synthase
transcript id: NM_001180202.1
SIO_010081: YDL142C
subclass of: SO_0000673
so part of: YDL142C
location: complement(<201719..>202570)
location: region:201719-202570:-1
so has part: feature:201719-202570:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:201719-202570:-1:exon

YDL142C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLS1
gene: CRD1
locus tag: YDL142C
gene synonym: CLS1
EC number: 2.7.8.41
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0008610 lipid biosynthetic process [PMID:7564918]
experiment: EXISTENCE:direct assay:GO:0008808 cardiolipin synthase activity [PMID:7564918]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:25843549]
experiment: EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:26235513]
experiment: EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:27402848]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:18799619]
experiment: EXISTENCE:mutant phenotype:GO:0007006 mitochondrial membrane organization [PMID:10777514]
experiment: EXISTENCE:mutant phenotype:GO:0008610 lipid biosynthetic process [PMID:9614098]
experiment: EXISTENCE:mutant phenotype:GO:0008808 cardiolipin synthase activity [PMID:9614098]
note: Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis
codon start: 1
product: cardiolipin synthase
translation: MIQMVPIYSCSALLRRTIPKRPFYHVLSGLTVRFKVNPQLNYNLFRDLTRREYATNPSKTPHIKSKLLNIPNILTLSRIGCTPFIGLFIITNNLTPALGLFAFSSITDFMDGYIARKYGLKTIAGTILDPLADKLLMITTTLALSVPSGPQIIPVSIAAIILGRDVLLAISALFIRYSTLKLKYPGRVAWNSYWDIVRYPSAEVRPSQLSKWNTFFQMVYLGSGVLLLLYEKEEGCEKTEEDFEDRKQDFQKAFSYLGYVTATTTIMSGVSYALKRNAFKLLK
SIO_010081: YDL142C
subclass of: SO_0000673
so part of: YDL142C
location: complement(201719..202570)
location: region:201719-202570:-1
so has part: feature:201719-202570:-1:exon

NP_010139.1
type: Protein
SIO_000068: ncbiprotein

S000002301
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:201719-202570:-1:exon

YDL141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACC2
gene: BPL1
locus tag: YDL141W
gene synonym: ACC2
so part of: sequence
location: <203039..>205111
location: region:203039-205111:1
so has part: feature:203039-205111:1:exon
subclass of: SO_0000010

851414
type: Gene
SIO_000068: ncbigene

position:203039:1
position: 203039
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:205111:1
position: 205111
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:203039-205111:1:exon

YDL141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACC2
gene: BPL1
locus tag: YDL141W
gene synonym: ACC2
product: biotin--[acetyl-CoA-carboxylase] ligase BPL1
transcript id: NM_001180201.1
SIO_010081: YDL141W
subclass of: SO_0000673
so part of: YDL141W
location: <203039..>205111
location: region:203039-205111:1
so has part: feature:203039-205111:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:203039-205111:1:exon

YDL141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACC2
gene: BPL1
locus tag: YDL141W
gene synonym: ACC2
EC number: 6.3.4.9
EC number: 6.3.4.10
EC number: 6.3.4.11
EC number: 6.3.4.15
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0036211 protein modification process [PMID:10551847]
experiment: EXISTENCE:direct assay:GO:0071734 biotin-[pyruvate-carboxylase] ligase activity [PMID:10551847]
experiment: EXISTENCE:mutant phenotype:GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity [PMID:6108218]
experiment: EXISTENCE:mutant phenotype:GO:0036211 protein modification process [PMID:6108218]
note: Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant
codon start: 1
product: biotin--[acetyl-CoA-carboxylase] ligase BPL1
translation: MNVLVYNGPGTTPGSVKHAVESLRDFLEPYYAVSTVNVKVLQTEPWMSKTSAVVFPGGADLPYVQACQPIISRLKHFVSKQGGVFIGFCAGGYFGTSRVEFAQGDPTMEVSGSRDLRFFPGTSRGPAYNGFQYNSEAGARAVKLNLPDGSQFSTYFNGGAVFVDADKFDNVEILATYAEHPDVPSSDSGKGQSENPAAVVLCTVGRGKVLLTGPHPEFNVRFMRKSTDKHFLETVVENLKAQEIMRLKFMRTVLTKTGLNCNNDFNYVRAPNLTPLFMASAPNKRNYLQEMENNLAHHGMHANNVELCSELNAETDSFQFYRGYRASYDAASSSLLHKEPDEVPKTVIFPGVDEDIPPFQYTPNFDMKEYFKYLNVQNTIGSLLLYGEVVTSTSTILNNNKSLLSSIPESTLLHVGTIQVSGRGRGGNTWINPKGVCASTAVVTMPLQSPVTNRNISVVFVQYLSMLAYCKAILSYAPGFSDIPVRIKWPNDLYALSPTYYKRKNLKLVNTGFEHTKLPLGDIEPAYLKISGLLVNTHFINNKYCLLLGCGINLTSDGPTTSLQTWIDILNEERQQLHLDLLPAIKAEKLQALYMNNLEVILKQFINYGAAEILPSYYELWLHSNQIVTLPDHGNTQAMITGITEDYGLLIAKELVSGSSTQFTGNVYNLQPDGNTFDIFKSLIAKKVQS
SIO_010081: YDL141W
subclass of: SO_0000673
so part of: YDL141W
location: 203039..205111
location: region:203039-205111:1
so has part: feature:203039-205111:1:exon

NP_010140.1
type: Protein
SIO_000068: ncbiprotein

S000002300
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:203039-205111:1:exon

YDL140C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPB1
alternative label: RPB220
alternative label: SIT1
alternative label: SUA8
gene: RPO21
locus tag: YDL140C
gene synonym: RPB1; RPB220; SIT1; SUA8
so part of: sequence
location: complement(<205360..>210561)
location: region:205360-210561:-1
so has part: feature:205360-210561:-1:exon
subclass of: SO_0000010

851415
type: Gene
SIO_000068: ncbigene

position:205360:-1
position: 205360
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210561:-1
position: 210561
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:205360-210561:-1:exon

YDL140C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPB1
alternative label: RPB220
alternative label: SIT1
alternative label: SUA8
gene: RPO21
locus tag: YDL140C
gene synonym: RPB1; RPB220; SIT1; SUA8
product: DNA-directed RNA polymerase II core subunit RPO21
transcript id: NM_001180200.1
SIO_010081: YDL140C
subclass of: SO_0000673
so part of: YDL140C
location: complement(<205360..>210561)
location: region:205360-210561:-1
so has part: feature:205360-210561:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:205360-210561:-1:exon

YDL140C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPB1
alternative label: RPB220
alternative label: SIT1
alternative label: SUA8
gene: RPO21
locus tag: YDL140C
gene synonym: RPB1; RPB220; SIT1; SUA8
EC number: 2.7.7.6
experiment: EXISTENCE:direct assay:GO:0001055 RNA polymerase II activity [PMID:8288647]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2183013|PMID:2186966]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:3299050]
experiment: EXISTENCE:mutant phenotype:GO:0019985 translesion synthesis [PMID:22405652]
note: RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
codon start: 1
product: DNA-directed RNA polymerase II core subunit RPO21
translation: MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHMLKKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGAFDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGSNDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR
SIO_010081: YDL140C
subclass of: SO_0000673
so part of: YDL140C
location: complement(205360..210561)
location: region:205360-210561:-1
so has part: feature:205360-210561:-1:exon

NP_010141.1
type: Protein
SIO_000068: ncbiprotein

S000002299
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:205360-210561:-1:exon

YDL139C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCM3
locus tag: YDL139C
so part of: sequence
location: complement(<211375..>212046)
location: region:211375-212046:-1
so has part: feature:211375-212046:-1:exon
subclass of: SO_0000010

851416
type: Gene
SIO_000068: ncbigene

position:211375:-1
position: 211375
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:212046:-1
position: 212046
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:211375-212046:-1:exon

YDL139C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SCM3
locus tag: YDL139C
product: Scm3p
transcript id: NM_001180199.1
SIO_010081: YDL139C
subclass of: SO_0000673
so part of: YDL139C
location: complement(<211375..>212046)
location: region:211375-212046:-1
so has part: feature:211375-212046:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:211375-212046:-1:exon

YDL139C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SCM3
locus tag: YDL139C
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:17569568|PMID:17574026]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process [PMID:21070970]
experiment: EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:17548816]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:17569568|PMID:17574026]
experiment: EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:17569568]
experiment: EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:17548816|PMID:17569568]
experiment: EXISTENCE:mutant phenotype:GO:0097030 CENP-A containing nucleosome binding [PMID:21412236]
experiment: EXISTENCE:physical interaction:GO:0000779 condensed chromosome, centromeric region [PMID:17548816]
experiment: EXISTENCE:physical interaction:GO:0097030 CENP-A containing nucleosome binding [PMID:21412236]
note: Nonhistone component of centromeric chromatin; binds to histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP
codon start: 1
product: Scm3p
translation: MKTNKKISKRRSLKNLHGALKGLLKESGKKSESKIRKHSDCNPVHRVYPPNIEKRKTKKDDGISRPIAERNGHVYIMSKENHIIPKLTDDEVMERHKLADENMRKVWSNIISKYESIEEQGDLVDLKTGEIVEDNGHIKTLTANNSTKDKRTKYTSVLRDIIDISDEEDGDKNDEYTLWANDSEASDSEVDADNDTEEEKDEKLIDADFKKYEAKLSKRILRD
SIO_010081: YDL139C
subclass of: SO_0000673
so part of: YDL139C
location: complement(211375..212046)
location: region:211375-212046:-1
so has part: feature:211375-212046:-1:exon

NP_010142.2
type: Protein
SIO_000068: ncbiprotein

S000002298
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:211375-212046:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS409; Autonomously Replicating Sequence
so part of: sequence
location: 212519..212618
location: region:212519-212618:1
so has part: feature:212519-212618:1:region

S000118430
type: SGD
SIO_000068: sgd

position:212519:1
position: 212519
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:212618:1
position: 212618
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212519-212618:1:region

YDL138W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RGT2
locus tag: YDL138W
so part of: sequence
location: <213351..>215642
location: region:213351-215642:1
so has part: feature:213351-215642:1:exon
subclass of: SO_0000010

851417
type: Gene
SIO_000068: ncbigene

position:213351:1
position: 213351
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:215642:1
position: 215642
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:213351-215642:1:exon

YDL138W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RGT2
locus tag: YDL138W
product: glucose sensor
transcript id: NM_001180198.1
SIO_010081: YDL138W
subclass of: SO_0000673
so part of: YDL138W
location: <213351..>215642
location: region:213351-215642:1
so has part: feature:213351-215642:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:213351-215642:1:exon

YDL138W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RGT2
locus tag: YDL138W
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005536 glucose binding [PMID:29954842]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8901598]
experiment: EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:9564039]
experiment: EXISTENCE:mutant phenotype:GO:0051594 detection of glucose [PMID:8901598]
note: Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
codon start: 1
product: glucose sensor
translation: MNDSQNCLRQREENSHLNPGNDFGHHQGAECTINHNNMPHRNAYTESTNDTEAKSIVMCDDPNAYQISYTNNEPAGDGAIETTSILLSQPLPLRSNVMSVLVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDPRLLEELVEIKATYDYEASFGPSTLLDCFKTSENRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELFRKAPNSVISSKWNKKIRKRCLAFPISQQIEMKTNIKNAGKLDNNNSPIVQDDSHNIIDVDGFLENQIQSNDHMIAADKGSGSLVNIIDTAPLTSTEFKPVEHPPVNYVDLGNGLGLNTYNRGPPSIISDSTDEFYEENDSSYYNNNTERNGANSVNTYMAQLINSSSTTSNDTSFSPSHNSNARTSSNWTSDLASKHSQYTSPQ
SIO_010081: YDL138W
subclass of: SO_0000673
so part of: YDL138W
location: 213351..215642
location: region:213351-215642:1
so has part: feature:213351-215642:1:exon

NP_010143.1
type: Protein
SIO_000068: ncbiprotein

S000002297
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:213351-215642:1:exon

YDL137W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARF2
locus tag: YDL137W
so part of: sequence
location: <216529..>217074
location: region:216529-217074:1
so has part: feature:216529-217074:1:exon
subclass of: SO_0000010

851418
type: Gene
SIO_000068: ncbigene

position:216529:1
position: 216529
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:217074:1
position: 217074
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:216529-217074:1:exon

YDL137W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARF2
locus tag: YDL137W
product: Arf family GTPase ARF2
transcript id: NM_001180197.1
SIO_010081: YDL137W
subclass of: SO_0000673
so part of: YDL137W
location: <216529..>217074
location: region:216529-217074:1
so has part: feature:216529-217074:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:216529-217074:1:exon

YDL137W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARF2
locus tag: YDL137W
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8816753]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:20841378|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]
note: ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6
codon start: 1
product: Arf family GTPase ARF2
translation: MGLYASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRHYYRNTEGVIFVIDSNDRSRIGEAREVMQRMLNEDELRNAVWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQSTCATSGEGLYEGLEWLSNNLKNQS
SIO_010081: YDL137W
subclass of: SO_0000673
so part of: YDL137W
location: 216529..217074
location: region:216529-217074:1
so has part: feature:216529-217074:1:exon

NP_010144.1
type: Protein
SIO_000068: ncbiprotein

S000002296
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:216529-217074:1:exon

YDL136W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SOS2
gene: RPL35B
locus tag: YDL136W
gene synonym: SOS2
so part of: sequence
location: <217600..>218367
location: region:217600-218367:1
so has part: feature:217600-218367:1:exon
subclass of: SO_0000010

851419
type: Gene
SIO_000068: ncbigene

position:217600:1
position: 217600
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:218367:1
position: 218367
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:217600-218367:1:exon

YDL136W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SOS2
gene: RPL35B
locus tag: YDL136W
gene synonym: SOS2
product: ribosomal 60S subunit protein L35B
transcript id: NM_001180251.2
SIO_010081: YDL136W
subclass of: SO_0000673
so part of: YDL136W
location: join(<217600..217602,218008..>218367)
location: region:217600-218367:1
so has part: feature:217600-217602:1:exon
so has part: feature:218008-218367:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:217600-217602:1:exon

position:217602:1
position: 217602
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:218008-218367:1:exon

position:218008:1
position: 218008
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL136W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SOS2
gene: RPL35B
locus tag: YDL136W
gene synonym: SOS2
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:20392820]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:20392820]
note: Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L35B
translation: MAGVKAYELRTKSKEQLASQLVDLKKELAELKVQKLSRPSLPKIKTVRKSIACVLTVINEQQREAVRQLYKGKKYQPKDLRAKKTRALRRALTKFEASQVTEKQRKKQIAFPQRKYAIKA
SIO_010081: YDL136W
subclass of: SO_0000673
so part of: YDL136W
location: join(217600..217602,218008..218367)
location: region:217600-218367:1
so has part: feature:217600-217602:1:exon
so has part: feature:218008-218367:1:exon

NP_010090.1
type: Protein
SIO_000068: ncbiprotein

S000002295
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:217600-217602:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:218008-218367:1:exon

YDL135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDI1
locus tag: YDL135C
so part of: sequence
location: complement(<218680..>219288)
location: region:218680-219288:-1
so has part: feature:218680-219288:-1:exon
subclass of: SO_0000010

851420
type: Gene
SIO_000068: ncbigene

position:218680:-1
position: 218680
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:219288:-1
position: 219288
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:218680-219288:-1:exon

YDL135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RDI1
locus tag: YDL135C
product: Rdi1p
transcript id: NM_001180195.1
SIO_010081: YDL135C
subclass of: SO_0000673
so part of: YDL135C
location: complement(<218680..>219288)
location: region:218680-219288:-1
so has part: feature:218680-219288:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:218680-219288:-1:exon

YDL135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RDI1
locus tag: YDL135C
experiment: EXISTENCE:direct assay:GO:0005094 Rho GDP-dissociation inhibitor activity [PMID:10066831]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10066831|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15108020]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15108020]
experiment: EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:9242378]
experiment: EXISTENCE:direct assay:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:9242378]
experiment: EXISTENCE:physical interaction:GO:0007266 Rho protein signal transduction [PMID:9242378]
note: Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
codon start: 1
product: Rdi1p
translation: MAEESTDFSQFEEERNNDQYKVSAKKTVDEYKNLDAEDESLAKWKESLGLSSDVLPLEFPGDKRKVVVQKIQLLVNTEPNPITFDLTNEKTIKELASKRYKIKENSIYKLKIVFKVQHEIITGLRYVQYIKKAGIAVDKIDDHLGSYAPNTKTKPFYEVELPESEAPSGFLARGNYSAVSKFIDDDKTNHLTLNWGVEIVKK
SIO_010081: YDL135C
subclass of: SO_0000673
so part of: YDL135C
location: complement(218680..219288)
location: region:218680-219288:-1
so has part: feature:218680-219288:-1:exon

NP_010146.1
type: Protein
SIO_000068: ncbiprotein

S000002294
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:218680-219288:-1:exon

YDL134C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPH21
locus tag: YDL134C
so part of: sequence
location: complement(<219662..>220771)
location: region:219662-220771:-1
so has part: feature:219662-220771:-1:exon
subclass of: SO_0000010

851421
type: Gene
SIO_000068: ncbigene

position:219662:-1
position: 219662
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220771:-1
position: 220771
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:219662-220771:-1:exon

YDL134C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPH21
locus tag: YDL134C
product: phosphoprotein phosphatase 2A catalytic subunit PPH21
transcript id: NM_001180193.1
SIO_010081: YDL134C
subclass of: SO_0000673
so part of: YDL134C
location: complement(<219662..>220771)
location: region:219662-220771:-1
so has part: feature:219662-220771:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:219662-220771:-1:exon

YDL134C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPH21
locus tag: YDL134C
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:17550305]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]
experiment: EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:12820961]
experiment: EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]
experiment: EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:2176150]
experiment: EXISTENCE:physical interaction:GO:0006417 regulation of translation [PMID:10329624]
note: Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
codon start: 1
product: phosphoprotein phosphatase 2A catalytic subunit PPH21
translation: MDTDLDVPMQDAVTEQLTPTVSEDMDLNNNSSDNNAEEFSVDDLKPGSSGIADHKSSKPLELNNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPSVSRKTPDYFL
SIO_010081: YDL134C
subclass of: SO_0000673
so part of: YDL134C
location: complement(219662..220771)
location: region:219662-220771:-1
so has part: feature:219662-220771:-1:exon

NP_010147.1
type: Protein
SIO_000068: ncbiprotein

S000002292
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:219662-220771:-1:exon

YDL133C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL47B
alternative label: YDL134C-A
gene: RPL41B
locus tag: YDL133C-A
gene synonym: RPL47B; YDL134C-A
so part of: sequence
location: complement(<221724..>221801)
location: region:221724-221801:-1
so has part: feature:221724-221801:-1:exon
subclass of: SO_0000010

851422
type: Gene
SIO_000068: ncbigene

position:221724:-1
position: 221724
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:221801:-1
position: 221801
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221724-221801:-1:exon

YDL133C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL47B
alternative label: YDL134C-A
gene: RPL41B
locus tag: YDL133C-A
gene synonym: RPL47B; YDL134C-A
product: ribosomal 60S subunit protein L41B
transcript id: NM_001180194.1
SIO_010081: YDL133C-A
subclass of: SO_0000673
so part of: YDL133C-A
location: complement(<221724..>221801)
location: region:221724-221801:-1
so has part: feature:221724-221801:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221724-221801:-1:exon

YDL133C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL47B
alternative label: YDL134C-A
gene: RPL41B
locus tag: YDL133C-A
gene synonym: RPL47B; YDL134C-A
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
note: Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L41B
translation: MRAKWRKKRTRRLKRKRRKVRARSK
SIO_010081: YDL133C-A
subclass of: SO_0000673
so part of: YDL133C-A
location: complement(221724..221801)
location: region:221724-221801:-1
so has part: feature:221724-221801:-1:exon

NP_010148.1
type: Protein
SIO_000068: ncbiprotein

S000002293
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221724-221801:-1:exon

YDL133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRF1
locus tag: YDL133W
so part of: sequence
location: <222427..>223740
location: region:222427-223740:1
so has part: feature:222427-223740:1:exon
subclass of: SO_0000010

851423
type: Gene
SIO_000068: ncbigene

position:222427:1
position: 222427
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:223740:1
position: 223740
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222427-223740:1:exon

YDL133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRF1
locus tag: YDL133W
product: Srf1p
transcript id: NM_001180192.1
SIO_010081: YDL133W
subclass of: SO_0000673
so part of: YDL133W
location: <222427..>223740
location: region:222427-223740:1
so has part: feature:222427-223740:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:222427-223740:1:exon

YDL133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRF1
locus tag: YDL133W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0043085 positive regulation of catalytic activity [PMID:21347278]
note: Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
codon start: 1
product: Srf1p
translation: MGDSNSSQEAYSDTTSTNASRIADQNQLNLNVDLEKNQTVRKSGSLEALQNAKIHVPKHSDGSPLDYPKLNTYTFVPTTVPPYVLEAQFDKLRLQDKGTVDGNVTDDKNLPKEFKWGQFASTIGCHSAYTRDQNYNPSHKSYDGYSLSSSTSSKNAALREILGDMCSEWGGEERLEGVLHSEIGANLEFNTTEERKEWLQYIEKVKDFYYGDNKKNPESPESVHNKVYKSDWVNELNKEREKWRRLKQRKLQQWRPPLTSLLLDNQYLILGLRIFTGILSCISLALAIKIFQNSRSNNTISESKIGQQPSTIMAICVNAVAIAYIIYIAHDEFAGKPVGLRNPLSKLKLILLDLLFIIFSSANLALAFNTRFDKEWVCTSIRRSNGSTYGYPKIPRICRKQEALSAFLFVALFMWVITFSISIVRVVEKVSSITNRN
SIO_010081: YDL133W
subclass of: SO_0000673
so part of: YDL133W
location: 222427..223740
location: region:222427-223740:1
so has part: feature:222427-223740:1:exon

NP_010149.1
type: Protein
SIO_000068: ncbiprotein

S000002291
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:222427-223740:1:exon

YDL132W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDC53
locus tag: YDL132W
so part of: sequence
location: <224304..>226751
location: region:224304-226751:1
so has part: feature:224304-226751:1:exon
subclass of: SO_0000010

851424
type: Gene
SIO_000068: ncbigene

position:224304:1
position: 224304
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:226751:1
position: 226751
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224304-226751:1:exon

YDL132W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDC53
locus tag: YDL132W
product: cullin CDC53
transcript id: NM_001180191.1
SIO_010081: YDL132W
subclass of: SO_0000673
so part of: YDL132W
location: <224304..>226751
location: region:224304-226751:1
so has part: feature:224304-226751:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:224304-226751:1:exon

YDL132W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDC53
locus tag: YDL132W
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16421250]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9346239|PMID:10385629]
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:19882662|PMID:9346238|PMID:9346239]
experiment: EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:9346238]
experiment: EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:9736614|PMID:7954792]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8943317]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:9499404]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238|PMID:9346239]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:9499404]
note: Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant
codon start: 1
product: cullin CDC53
translation: MSETLPRSDDLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNYILNFKQSNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDEDIITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLENIQEGTSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGESYAYLA
SIO_010081: YDL132W
subclass of: SO_0000673
so part of: YDL132W
location: 224304..226751
location: region:224304-226751:1
so has part: feature:224304-226751:1:exon

NP_010150.1
type: Protein
SIO_000068: ncbiprotein

S000002290
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:224304-226751:1:exon

YDL131W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LYS21
locus tag: YDL131W
so part of: sequence
location: <227393..>228715
location: region:227393-228715:1
so has part: feature:227393-228715:1:exon
subclass of: SO_0000010

851425
type: Gene
SIO_000068: ncbigene

position:227393:1
position: 227393
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228715:1
position: 228715
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:227393-228715:1:exon

YDL131W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LYS21
locus tag: YDL131W
product: homocitrate synthase LYS21
transcript id: NM_001180190.1
SIO_010081: YDL131W
subclass of: SO_0000673
so part of: YDL131W
location: <227393..>228715
location: region:227393-228715:1
so has part: feature:227393-228715:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:227393-228715:1:exon

YDL131W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LYS21
locus tag: YDL131W
EC number: 2.3.3.14
experiment: EXISTENCE:direct assay:GO:0004410 homocitrate synthase activity [PMID:10103047]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9099739|PMID:11914276]
experiment: EXISTENCE:genetic interaction:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:18524920]
experiment: EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:18524920]
note: Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
codon start: 1
product: homocitrate synthase LYS21
translation: MSENNEFQSVTESTTAPTTSNPYGPNPADYLSNVKNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAKIKKLGDVRPLNIDDVDSIIKDFHAELSTPLLKPVNKGTDDDNIDISNGHVSKKAKVTK
SIO_010081: YDL131W
subclass of: SO_0000673
so part of: YDL131W
location: 227393..228715
location: region:227393-228715:1
so has part: feature:227393-228715:1:exon

NP_010151.1
type: Protein
SIO_000068: ncbiprotein

S000002289
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:227393-228715:1:exon

YDL130W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIS2
gene: STF1
locus tag: YDL130W-A
gene synonym: AIS2
so part of: sequence
location: <229171..>229431
location: region:229171-229431:1
so has part: feature:229171-229431:1:exon
subclass of: SO_0000010

851426
type: Gene
SIO_000068: ncbigene

position:229171:1
position: 229171
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229431:1
position: 229431
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229171-229431:1:exon

YDL130W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIS2
gene: STF1
locus tag: YDL130W-A
gene synonym: AIS2
product: ATPase-binding protein
transcript id: NM_001184325.1
SIO_010081: YDL130W-A
subclass of: SO_0000673
so part of: YDL130W-A
location: <229171..>229431
location: region:229171-229431:1
so has part: feature:229171-229431:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229171-229431:1:exon

YDL130W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIS2
gene: STF1
locus tag: YDL130W-A
gene synonym: AIS2
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12167646|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0032780 negative regulation of ATP-dependent activity [PMID:12809520]
experiment: EXISTENCE:direct assay:GO:0051117 ATPase binding [PMID:2172220]
note: Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication
codon start: 1
product: ATPase-binding protein
translation: MLNRCISRNTRLPVNLRIASRFYSDGPLGGAGPGNPQDIFIKRERAKEDYYARQQEREQLAHVKEQLKEHKKKLENLENKINNLSK
SIO_010081: YDL130W-A
subclass of: SO_0000673
so part of: YDL130W-A
location: 229171..229431
location: region:229171-229431:1
so has part: feature:229171-229431:1:exon

NP_010152.1
type: Protein
SIO_000068: ncbiprotein

S000007232
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229171-229431:1:exon

YDL130W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL44'
alternative label: RPLA3
gene: RPP1B
locus tag: YDL130W
gene synonym: RPL44'; RPLA3
so part of: sequence
location: <229906..>230527
location: region:229906-230527:1
so has part: feature:229906-230527:1:exon
subclass of: SO_0000010

851427
type: Gene
SIO_000068: ncbigene

position:229906:1
position: 229906
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:230527:1
position: 230527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229906-230527:1:exon

YDL130W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL44'
alternative label: RPLA3
gene: RPP1B
locus tag: YDL130W
gene synonym: RPL44'; RPLA3
product: ribosomal protein P1B
transcript id: NM_001180189.1
SIO_010081: YDL130W
subclass of: SO_0000673
so part of: YDL130W
location: join(<229906..230019,230321..>230527)
location: region:229906-230527:1
so has part: feature:229906-230019:1:exon
so has part: feature:230321-230527:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229906-230019:1:exon

position:230019:1
position: 230019
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:230321-230527:1:exon

position:230321:1
position: 230321
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL130W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL44'
alternative label: RPLA3
gene: RPP1B
locus tag: YDL130W
gene synonym: RPL44'; RPLA3
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
experiment: EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1601875]
note: Ribosomal protein P1 beta; component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
codon start: 1
product: ribosomal protein P1B
translation: MSDSIISFAAFILADAGLEITSDNLLTITKAAGANVDNVWADVYAKALEGKDLKEILSGFHNAGPVAGAGAASGAAAAGGDAAAEEEKEEEAAEESDDDMGFGLFD
SIO_010081: YDL130W
subclass of: SO_0000673
so part of: YDL130W
location: join(229906..230019,230321..230527)
location: region:229906-230527:1
so has part: feature:229906-230019:1:exon
so has part: feature:230321-230527:1:exon

NP_010153.1
type: Protein
SIO_000068: ncbiprotein

S000002288
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229906-230019:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:230321-230527:1:exon

YDL129W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL129W
so part of: sequence
location: <231024..>231899
location: region:231024-231899:1
so has part: feature:231024-231899:1:exon
subclass of: SO_0000010

851428
type: Gene
SIO_000068: ncbigene

position:231024:1
position: 231024
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:231899:1
position: 231899
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231024-231899:1:exon

YDL129W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL129W
product: uncharacterized protein
transcript id: NM_001180188.1
SIO_010081: YDL129W
subclass of: SO_0000673
so part of: YDL129W
location: <231024..>231899
location: region:231024-231899:1
so has part: feature:231024-231899:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:231024-231899:1:exon

YDL129W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL129W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276|PMID:22842922]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MELRSRRSAEAYLVTPEEPAKNKSERSIESNERVGTREAKSENTSVFSPAYSDTATTDSSKKVDDNEYYNFTSHFMPSLKNTRELENTILNLIQRIKEGDDETLVSEKDLILSVLNRSLASTSHWKLQAQLSELRATSEGRYAVETNLLKKEVEFLKNKTPKTNESASSAELRPLLERPLKRKLSLPGLAQRPLSTGARLEGGYGGVSPNSWKTKVPKLPLPASRPSLNLSPQKVPTGTDKVEEDTKIDTLELVENNKPHPRMRRRSDNPATNEYVRVFHLEKKEPKSRKK
SIO_010081: YDL129W
subclass of: SO_0000673
so part of: YDL129W
location: 231024..231899
location: region:231024-231899:1
so has part: feature:231024-231899:1:exon

NP_010154.1
type: Protein
SIO_000068: ncbiprotein

S000002287
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:231024-231899:1:exon

YDL128W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HUM1
alternative label: MNR1
gene: VCX1
locus tag: YDL128W
gene synonym: HUM1; MNR1
so part of: sequence
location: <232652..>233887
location: region:232652-233887:1
so has part: feature:232652-233887:1:exon
subclass of: SO_0000010

851429
type: Gene
SIO_000068: ncbigene

position:232652:1
position: 232652
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:233887:1
position: 233887
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232652-233887:1:exon

YDL128W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HUM1
alternative label: MNR1
gene: VCX1
locus tag: YDL128W
gene synonym: HUM1; MNR1
product: Vcx1p
transcript id: NM_001180187.1
SIO_010081: YDL128W
subclass of: SO_0000673
so part of: YDL128W
location: <232652..>233887
location: region:232652-233887:1
so has part: feature:232652-233887:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232652-233887:1:exon

YDL128W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HUM1
alternative label: MNR1
gene: VCX1
locus tag: YDL128W
gene synonym: HUM1; MNR1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:8628289]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20709757|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:8628289]
experiment: EXISTENCE:direct assay:GO:0015369 calcium:proton antiporter activity [PMID:8628289]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:8628289]
experiment: EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:8628289]
experiment: EXISTENCE:mutant phenotype:GO:0006874 cellular calcium ion homeostasis [PMID:8628289]
experiment: EXISTENCE:mutant phenotype:GO:0015369 calcium:proton antiporter activity [PMID:20709757|PMID:8628289]
experiment: EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:20709757]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:8628289]
note: Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
codon start: 1
product: Vcx1p
translation: MDATTPLLTVANSHPARNPKHTAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAIIPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVRIVQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQTAAQTMSSLLAIACASLLIPAAFRATLPHGKEDHFIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGESNWLEGVMSLAMYILIAMAFFYYPDEKTLDSIGNSL
SIO_010081: YDL128W
subclass of: SO_0000673
so part of: YDL128W
location: 232652..233887
location: region:232652-233887:1
so has part: feature:232652-233887:1:exon

NP_010155.1
type: Protein
SIO_000068: ncbiprotein

S000002286
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232652-233887:1:exon

YDL127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLN4
gene: PCL2
locus tag: YDL127W
gene synonym: CLN4
so part of: sequence
location: <234927..>235853
location: region:234927-235853:1
so has part: feature:234927-235853:1:exon
subclass of: SO_0000010

851430
type: Gene
SIO_000068: ncbigene

position:234927:1
position: 234927
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:235853:1
position: 235853
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234927-235853:1:exon

YDL127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLN4
gene: PCL2
locus tag: YDL127W
gene synonym: CLN4
product: cyclin PCL2
transcript id: NM_001180186.1
SIO_010081: YDL127W
subclass of: SO_0000673
so part of: YDL127W
location: <234927..>235853
location: region:234927-235853:1
so has part: feature:234927-235853:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234927-235853:1:exon

YDL127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLN4
gene: PCL2
locus tag: YDL127W
gene synonym: CLN4
experiment: EXISTENCE:direct assay:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:7973731]
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14688790]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14688790]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:14688790]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14688790]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7973731]
experiment: EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:19458192]
experiment: EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:7973731]
experiment: EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]
note: Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication
codon start: 1
product: cyclin PCL2
translation: MSNYEALLKFNRKAVSKEMVQYLASTTASIIKIKKTNSMIDIALPAPPLTKFINRLIKHSNVQTPTLMATSVYLAKLRSIIPSNVYGIETTRHRIFLGCLILAAKTLNDSSPLNKHWAEYTDGLLILREVNTIERELLEYFDWDVTISTDDLITCLSPFLKPIKEEQLYKSQRDCRTLKNFSAQEKDIVNKTSISHSRSSSNMSIPSLASTSTLSTLESRRSNLSNYSNRIRTLPELHESNNISDKFSPRTYNIDSKHDNKENRPIPTIKPFNFSKARPVILKTGLNKQIIKEDTKVKKSNWSNYFKS
SIO_010081: YDL127W
subclass of: SO_0000673
so part of: YDL127W
location: 234927..235853
location: region:234927-235853:1
so has part: feature:234927-235853:1:exon

NP_010156.2
type: Protein
SIO_000068: ncbiprotein

S000002285
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234927-235853:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS409.5; Strong autonomously replicating sequence
so part of: sequence
location: 235937..236185
location: region:235937-236185:1
so has part: feature:235937-236185:1:region

S000178064
type: SGD
SIO_000068: sgd

position:235937:1
position: 235937
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:236185:1
position: 236185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:235937-236185:1:region

YDL126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDC48
locus tag: YDL126C
so part of: sequence
location: complement(<236157..>238664)
location: region:236157-238664:-1
so has part: feature:236157-238664:-1:exon
subclass of: SO_0000010

851431
type: Gene
SIO_000068: ncbigene

position:236157:-1
position: 236157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238664:-1
position: 238664
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:236157-238664:-1:exon

YDL126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDC48
locus tag: YDL126C
product: AAA family ATPase CDC48
transcript id: NM_001180185.1
SIO_010081: YDL126C
subclass of: SO_0000673
so part of: YDL126C
location: complement(<236157..>238664)
location: region:236157-238664:-1
so has part: feature:236157-238664:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:236157-238664:-1:exon

YDL126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDC48
locus tag: YDL126C
EC number: 3.6.4.6
experiment: EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9436996|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:21070972|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15910746]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15910746|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006274 DNA replication termination [PMID:31509741]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:7492595]
experiment: EXISTENCE:direct assay:GO:0030894 replisome [PMID:31509741]
experiment: EXISTENCE:direct assay:GO:0030970 retrograde protein transport, ER to cytosol [PMID:32588820]
experiment: EXISTENCE:direct assay:GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex [PMID:11598205|PMID:11733065]
experiment: EXISTENCE:direct assay:GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex [PMID:21070972]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:11733065]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]
experiment: EXISTENCE:genetic interaction:GO:0032984 protein-containing complex disassembly [PMID:26255844]
experiment: EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]
experiment: EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:29309037]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20855502]
experiment: EXISTENCE:mutant phenotype:GO:0016320 endoplasmic reticulum membrane fusion [PMID:7553849]
experiment: EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:23418575]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:11739805|PMID:11756557]
experiment: EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:11740563|PMID:32588820]
experiment: EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:20483956]
experiment: EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:25342810|PMID:26255844]
experiment: EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:20508643]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:20855502]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:20206597|PMID:29309037]
experiment: EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]
experiment: EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:14636562]
experiment: EXISTENCE:mutant phenotype:GO:0051974 negative regulation of telomerase activity [PMID:26365526]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]
experiment: EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:18812321]
experiment: EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:22718752]
experiment: EXISTENCE:mutant phenotype:GO:0071712 ER-associated misfolded protein catabolic process [PMID:11740563|PMID:11813000]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579|PMID:21070972]
experiment: EXISTENCE:mutant phenotype:GO:0099638 endosome to plasma membrane protein transport [PMID:36125415]
experiment: EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]
experiment: EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:11598205|PMID:11733065]
experiment: EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23358411|PMID:23479637]
experiment: EXISTENCE:mutant phenotype:GO:1990171 SCF complex disassembly in response to cadmium stress [PMID:23000173]
experiment: EXISTENCE:mutant phenotype:GO:2001168 positive regulation of histone H2B ubiquitination [PMID:25183520]
experiment: EXISTENCE:physical interaction:GO:1990112 RQC complex [PMID:23479637]
note: AAA ATPase with protein-unfoldase activity; subunit of polyUb-selective segregase complex involved in ERAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, ribosome-associated degradation, ribophagy, homotypic ER membrane fusion, SCF complex disassembly, cell wall integrity, and telomerase regulation; mobilizes membrane-anchored transcription factors by regulated Ub/proteasome-dependent processing (RUP); human ortholog VCP complements a cdc48 mutant
codon start: 1
product: AAA family ATPase CDC48
translation: MGEEHKPLLDASGVDPREEDKTATAILRRKKKDNMLLVDDAINDDNSVIAINSNTMDKLELFRGDTVLVKGKKRKDTVLIVLIDDELEDGACRINRVVRNNLRIRLGDLVTIHPCPDIKYATRISVLPIADTIEGITGNLFDVFLKPYFVEAYRPVRKGDHFVVRGGMRQVEFKVVDVEPEEYAVVAQDTIIHWEGEPINREDEENNMNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKAIGIKPPRGVLMYGPPGTGKTLMARAVANETGAFFFLINGPEVMSKMAGESESNLRKAFEEAEKNAPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEVLRIHTKNMKLADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLIDLDEDEIDAEVLDSLGVTMDNFRFALGNSNPSALRETVVESVNVTWDDVGGLDEIKEELKETVEYPVLHPDQYTKFGLSPSKGVLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESESNIRDIFDKARAAAPTVVFLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMNAKKNVFVIGATNRPDQIDPAILRPGRLDQLIYVPLPDENARLSILNAQLRKTPLEPGLELTAIAKATQGFSGADLLYIVQRAAKYAIKDSIEAHRQHEAEKEVKVEGEDVEMTDEGAKAEQEPEVDPVPYITKEHFAEAMKTAKRSVSDAELRRYEAYSQQMKASRGQFSNFNFNDAPLGTTATDNANSNNSAPSGAGAAFGSNAEEDDDLYS
SIO_010081: YDL126C
subclass of: SO_0000673
so part of: YDL126C
location: complement(236157..238664)
location: region:236157-238664:-1
so has part: feature:236157-238664:-1:exon

NP_010157.1
type: Protein
SIO_000068: ncbiprotein

S000002284
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:236157-238664:-1:exon

YDL125C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HNT1
locus tag: YDL125C
so part of: sequence
location: complement(<239019..>239606)
location: region:239019-239606:-1
so has part: feature:239019-239606:-1:exon
subclass of: SO_0000010

851432
type: Gene
SIO_000068: ncbigene

position:239019:-1
position: 239019
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:239606:-1
position: 239606
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:239019-239606:-1:exon

YDL125C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HNT1
locus tag: YDL125C
product: adenosine 5'-monophosphoramidase
transcript id: NM_001180184.1
SIO_010081: YDL125C
subclass of: SO_0000673
so part of: YDL125C
location: complement(join(<239019..239398,239510..>239606))
location: region:239019-239606:-1
so has part: feature:239510-239606:-1:exon
so has part: feature:239019-239398:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:239510-239606:-1:exon

position:239510:-1
position: 239510
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:239019-239398:-1:exon

position:239398:-1
position: 239398
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDL125C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HNT1
locus tag: YDL125C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0009117 nucleotide metabolic process [PMID:11805111]
experiment: EXISTENCE:direct assay:GO:0043530 adenosine 5'-monophosphoramidase activity [PMID:11805111]
experiment: EXISTENCE:mutant phenotype:GO:0010043 response to zinc ion [PMID:31692084]
note: Adenosine 5'-monophosphoramidase; interacts physically and genetically with CDK and TFIIK subunit Kin28p, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant
codon start: 1
product: adenosine 5'-monophosphoramidase
translation: MEPLISAPYLTTTKMSAPATLDAACIFCKIIKSEIPSFKLIETKYSYAFLDIQPTAEGHALIIPKYHGAKLHDIPDEFLTDAMPIAKRLAKAMKLDTYNVLQNNGKIAHQEVDHVHFHLIPKRDEKSGLIVGWPAQETDFDKLGKLHKELLAKLEGSD
SIO_010081: YDL125C
subclass of: SO_0000673
so part of: YDL125C
location: complement(join(239019..239398,239510..239606))
location: region:239019-239606:-1
so has part: feature:239510-239606:-1:exon
so has part: feature:239019-239398:-1:exon

NP_010158.1
type: Protein
SIO_000068: ncbiprotein

S000002283
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:239510-239606:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:239019-239398:-1:exon

YDL124W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL124W
so part of: sequence
location: <240259..>241197
location: region:240259-241197:1
so has part: feature:240259-241197:1:exon
subclass of: SO_0000010

851433
type: Gene
SIO_000068: ncbigene

position:240259:1
position: 240259
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241197:1
position: 241197
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:240259-241197:1:exon

YDL124W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL124W
product: aldo-keto reductase superfamily protein
transcript id: NM_001180183.1
SIO_010081: YDL124W
subclass of: SO_0000673
so part of: YDL124W
location: <240259..>241197
location: region:240259-241197:1
so has part: feature:240259-241197:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:240259-241197:1:exon

YDL124W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL124W
experiment: EXISTENCE:direct assay:GO:0004032 alditol:NADP+ 1-oxidoreductase activity [PMID:11306085]
experiment: EXISTENCE:direct assay:GO:0004033 aldo-keto reductase (NADP) activity [PMID:17140678]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0006725 cellular aromatic compound metabolic process [PMID:16268655]
experiment: EXISTENCE:direct assay:GO:0042180 cellular ketone metabolic process [PMID:17140678]
experiment: EXISTENCE:direct assay:GO:0043603 amide metabolic process [PMID:15564669]
experiment: EXISTENCE:direct assay:GO:0051268 alpha-keto amide reductase activity [PMID:15564669]
experiment: EXISTENCE:direct assay:GO:0051269 alpha-keto ester reductase activity [PMID:15564669]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]
note: NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
codon start: 1
product: aldo-keto reductase superfamily protein
translation: MSFHQQFFTLNNGNKIPAIAIIGTGTRWYKNEETDATFSNSLVEQIVYALKLPGIIHIDAAEIYRTYPEVGKALSLTEKPRNAIFLTDKYSPQIKMSDSPADGLDLALKKMGTDYVDLYLLHSPFVSKEVNGLSLEEAWKDMEQLYKSGKAKNIGVSNFAVEDLQRILKVAEVKPQVNQIEFSPFLQNQTPGIYKFCQEHDILVEAYSPLGPLQKKTAQDDSQPFFEYVKELSEKYIKSEAQIILRWVTKRGVLPVTTSSKPQRISDAQNLFSFDLTAEEVDKITELGLEHEPLRLYWNKLYGKYNYAAQKV
SIO_010081: YDL124W
subclass of: SO_0000673
so part of: YDL124W
location: 240259..241197
location: region:240259-241197:1
so has part: feature:240259-241197:1:exon

NP_010159.1
type: Protein
SIO_000068: ncbiprotein

S000002282
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:240259-241197:1:exon

YDL123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNA4
locus tag: YDL123W
so part of: sequence
location: <241418..>241840
location: region:241418-241840:1
so has part: feature:241418-241840:1:exon
subclass of: SO_0000010

851434
type: Gene
SIO_000068: ncbigene

position:241418:1
position: 241418
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241840:1
position: 241840
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241418-241840:1:exon

YDL123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNA4
locus tag: YDL123W
product: Sna4p
transcript id: NM_001180182.1
SIO_010081: YDL123W
subclass of: SO_0000673
so part of: YDL123W
location: <241418..>241840
location: region:241418-241840:1
so has part: feature:241418-241840:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:241418-241840:1:exon

YDL123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNA4
locus tag: YDL123W
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:19168755]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11566881|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000328 fungal-type vacuole lumen [PMID:19168755]
experiment: EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:19168755]
note: hypothetical protein; localized to the vacuolar outer membrane; predicted to be palmitoylated
codon start: 1
product: Sna4p
translation: MCCYCVCCTVSDFILYIVAFFFPPAAVLLRSGPCSSDFLLNVLLTLLGFLPGMLHAFYYITITSPLRNAEYVYYYQQGWVDSERNVPSNRPQNSQTPQNRPQQGSSARNVYPSVETPLLQGAAPHDNKQSLVESPPPYVP
SIO_010081: YDL123W
subclass of: SO_0000673
so part of: YDL123W
location: 241418..241840
location: region:241418-241840:1
so has part: feature:241418-241840:1:exon

NP_010160.1
type: Protein
SIO_000068: ncbiprotein

S000002281
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:241418-241840:1:exon

YDL122W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBP1
locus tag: YDL122W
so part of: sequence
location: <242552..>244981
location: region:242552-244981:1
so has part: feature:242552-244981:1:exon
subclass of: SO_0000010

851435
type: Gene
SIO_000068: ncbigene

position:242552:1
position: 242552
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:244981:1
position: 244981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:242552-244981:1:exon

YDL122W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBP1
locus tag: YDL122W
product: ubiquitin-specific protease UBP1
transcript id: NM_001180181.1
SIO_010081: YDL122W
subclass of: SO_0000673
so part of: YDL122W
location: <242552..>244981
location: region:242552-244981:1
so has part: feature:242552-244981:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:242552-244981:1:exon

YDL122W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBP1
locus tag: YDL122W
EC number: 3.4.19.12
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1429680]
experiment: EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15635103]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15635103|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:31713515]
experiment: EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:1429680|PMID:2050695]
experiment: EXISTENCE:direct assay:GO:1905524 negative regulation of protein autoubiquitination [PMID:31713515]
note: Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
codon start: 1
product: ubiquitin-specific protease UBP1
translation: MDLFIESKINSLLQFLFGSRQDFLRNFKTWSNNNNNLSIYLLIFGIVVFFYKKPDHLNYIVESVSEMTTNFRNNNSLSRWLPRSKFTHLDEEILKRGGFIAGLVNDGNTCFMNSVLQSLASSRELMEFLDNNVIRTYEEIEQNEHNEEGNGQESAQDEATHKKNTRKGGKVYGKHKKKLNRKSSSKEDEEKSQEPDITFSVALRDLLSALNAKYYRDKPYFKTNSLLKAMSKSPRKNILLGYDQEDAQEFFQNILAELESNVKSLNTEKLDTTPVAKSELPDDALVGQLNLGEVGTVYIPTEQIDPNSILHDKSIQNFTPFKLMTPLDGITAERIGCLQCGENGGIRYSVFSGLSLNLPNENIGSTLKLSQLLSDWSKPEIIEGVECNRCALTAAHSHLFGQLKEFEKKPEGSIPEKLINAVKDRVHQIEEVLAKPVIDDEDYKKLHTANMVRKCSKSKQILISRPPPLLSIHINRSVFDPRTYMIRKNNSKVLFKSRLNLAPWCCDINEINLDARLPMSKKEKAAQQDSSEDENIGGEYYTKLHERFEQEFEDSEEEKEYDDAEGNYASHYNHTKDISNYDPLNGEVDGVTSDDEDEYIEETDALGNTIKKRIIEHSDVENENVKDNEELQEIDNVSLDEPKINVEDQLETSSDEEDVIPAPPINYARSFSTVPATPLTYSLRSVIVHYGTHNYGHYIAFRKYRGCWWRISDETVYVVDEAEVLSTPGVFMLFYEYDFDEETGKMKDDLEAIQSNNEEDDEKEQEQKGVQEPKESQEQGEGEEQEEGQEQMKFERTEDHRDISGKDVN
SIO_010081: YDL122W
subclass of: SO_0000673
so part of: YDL122W
location: 242552..244981
location: region:242552-244981:1
so has part: feature:242552-244981:1:exon

NP_010161.1
type: Protein
SIO_000068: ncbiprotein

S000002280
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:242552-244981:1:exon

YDL121C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EXP1
locus tag: YDL121C
so part of: sequence
location: complement(<245133..>245582)
location: region:245133-245582:-1
so has part: feature:245133-245582:-1:exon
subclass of: SO_0000010

851436
type: Gene
SIO_000068: ncbigene

position:245133:-1
position: 245133
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245582:-1
position: 245582
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245133-245582:-1:exon

YDL121C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EXP1
locus tag: YDL121C
product: Exp1p
transcript id: NM_001180180.1
SIO_010081: YDL121C
subclass of: SO_0000673
so part of: YDL121C
location: complement(<245133..>245582)
location: region:245133-245582:-1
so has part: feature:245133-245582:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:245133-245582:-1:exon

YDL121C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EXP1
locus tag: YDL121C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10684247|PMID:14562095|PMID:26928762]
note: A cargo receptor protein for Pma1p; works with Psg1p to promote the transport and maturation of Pma1p; localizes to the ER and COPII vesicles; a non-essential protein
codon start: 1
product: Exp1p
translation: MNLYGYFLLLIIVIAFIALLPLFSGIGTFKLTKPKSSATAQSATGKLGKREYLKKKLDHTNVLKFDLKDTEESLGHDSASASSASRKFEIDSKTGLKRRVIGQYNKDPNDFDFDIDDLINEDELDERREEEKKLKKYNGKKNEAYEGFV
SIO_010081: YDL121C
subclass of: SO_0000673
so part of: YDL121C
location: complement(245133..245582)
location: region:245133-245582:-1
so has part: feature:245133-245582:-1:exon

NP_010162.1
type: Protein
SIO_000068: ncbiprotein

S000002279
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:245133-245582:-1:exon

YDL120W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YFH1
locus tag: YDL120W
so part of: sequence
location: <245923..>246447
location: region:245923-246447:1
so has part: feature:245923-246447:1:exon
subclass of: SO_0000010

851437
type: Gene
SIO_000068: ncbigene

position:245923:1
position: 245923
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246447:1
position: 246447
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245923-246447:1:exon

YDL120W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YFH1
locus tag: YDL120W
product: ferroxidase
transcript id: NM_001180179.1
SIO_010081: YDL120W
subclass of: SO_0000673
so part of: YDL120W
location: <245923..>246447
location: region:245923-246447:1
so has part: feature:245923-246447:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:245923-246447:1:exon

YDL120W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YFH1
locus tag: YDL120W
EC number: 1.16.3.1
experiment: EXISTENCE:direct assay:GO:0004322 ferroxidase activity [PMID:12149269|PMID:12732649]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9180083|PMID:9241271|PMID:14576278|PMID:16823961|PMI D:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10428860]
experiment: EXISTENCE:direct assay:GO:0006879 cellular iron ion homeostasis [PMID:9180083]
experiment: EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:10930361|PMID:16784228]
experiment: EXISTENCE:direct assay:GO:0016226 iron-sulfur cluster assembly [PMID:12947415]
experiment: EXISTENCE:direct assay:GO:0034986 iron chaperone activity [PMID:12732649]
experiment: EXISTENCE:genetic interaction:GO:0006879 cellular iron ion homeostasis [PMID:11734220|PMID:9180083]
experiment: EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:14741370]
experiment: EXISTENCE:genetic interaction:GO:0034986 iron chaperone activity [PMID:15247478]
experiment: EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:18562474]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:11734220|PMID:9180083]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:12221295|PMID:12947415|PMID:12970193]
experiment: EXISTENCE:physical interaction:GO:0016226 iron-sulfur cluster assembly [PMID:14741370]
note: Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant
codon start: 1
product: ferroxidase
translation: MIKRSLASLVRVSSVMGRRYMIAAAGGERARFCPAVTNKKNHTVNTFQKRFVESSTDGQVVPQEVLNLPLEKYHEEADDYLDHLLDSLEELSEAHPDCIPDVELSHGVMTLEIPAFGTYVINKQPPNKQIWLASPLSGPNRFDLLNGEWVSLRNGTKLTDILTEEVEKAISKSQ
SIO_010081: YDL120W
subclass of: SO_0000673
so part of: YDL120W
location: 245923..246447
location: region:245923-246447:1
so has part: feature:245923-246447:1:exon

NP_010163.1
type: Protein
SIO_000068: ncbiprotein

S000002278
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:245923-246447:1:exon

YDL119C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HEM25
locus tag: YDL119C
so part of: sequence
location: complement(<246689..>247612)
location: region:246689-247612:-1
so has part: feature:246689-247612:-1:exon
subclass of: SO_0000010

851439
type: Gene
SIO_000068: ncbigene

position:246689:-1
position: 246689
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:247612:-1
position: 247612
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246689-247612:-1:exon

YDL119C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HEM25
locus tag: YDL119C
product: Hem25p
transcript id: NM_001180178.1
SIO_010081: YDL119C
subclass of: SO_0000673
so part of: YDL119C
location: complement(<246689..>247612)
location: region:246689-247612:-1
so has part: feature:246689-247612:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246689-247612:-1:exon

YDL119C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HEM25
locus tag: YDL119C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:27476175|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0015187 glycine transmembrane transporter activity [PMID:27476175]
experiment: EXISTENCE:genetic interaction:GO:0006783 heme biosynthetic process [PMID:26821380]
experiment: EXISTENCE:genetic interaction:GO:0015187 glycine transmembrane transporter activity [PMID:26821380]
experiment: EXISTENCE:genetic interaction:GO:1904983 glycine import into mitochondrion [PMID:26821380]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:26821380|PMID:27476175]
experiment: EXISTENCE:mutant phenotype:GO:0015187 glycine transmembrane transporter activity [PMID:26821380|PMID:27476175]
experiment: EXISTENCE:mutant phenotype:GO:1904983 glycine import into mitochondrion [PMID:26821380|PMID:27476175]
note: Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
codon start: 1
product: Hem25p
translation: MTEQATKPRNSSHLIGGFFGGLTSAVALQPLDLLKTRIQQDKKATLWKNLKEIDSPLQLWRGTLPSALRTSIGSALYLSCLNLMRSSLAKRRNAVPSLTNDSNIVYNKSSSLPRLTMYENLLTGAFARGLVGYITMPITVIKVRYESTLYNYSSLKEAITHIYTKEGLFGFFRGFGATCLRDAPYAGLYVLLYEKSKQLLPMVLPSRFIHYNPEGGFTTYTSTTVNTTSAVLSASLATTVTAPFDTIKTRMQLEPSKFTNSFNTFTSIVKNENVLKLFSGLSMRLARKAFSAGIAWGIYEELVKRFM
SIO_010081: YDL119C
subclass of: SO_0000673
so part of: YDL119C
location: complement(246689..247612)
location: region:246689-247612:-1
so has part: feature:246689-247612:-1:exon

NP_010164.1
type: Protein
SIO_000068: ncbiprotein

S000002277
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246689-247612:-1:exon

YDL117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CYK3
locus tag: YDL117W
so part of: sequence
location: <248581..>251238
location: region:248581-251238:1
so has part: feature:248581-251238:1:exon
subclass of: SO_0000010

851440
type: Gene
SIO_000068: ncbigene

position:248581:1
position: 248581
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:251238:1
position: 251238
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248581-251238:1:exon

YDL117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CYK3
locus tag: YDL117W
product: Cyk3p
transcript id: NM_001180176.1
SIO_010081: YDL117W
subclass of: SO_0000673
so part of: YDL117W
location: <248581..>251238
location: region:248581-251238:1
so has part: feature:248581-251238:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248581-251238:1:exon

YDL117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CYK3
locus tag: YDL117W
experiment: EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:21498574]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21498574|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:22956544]
experiment: EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]
experiment: EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]
experiment: EXISTENCE:physical interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]
note: SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
codon start: 1
product: Cyk3p
translation: MATNLTSLKPPFKVKARYGWSGQTKGDLGFLEGDIMEVTRIAGSWFYGKLLRNKKCSGYFPHNFVILLEERLNSSTENGRQPSKIVESFEKSNKVVIPPVPSRYSDERPRPKKKLSSSMPNSPKKPVDSLTKARKAKSKEMVNEKNIYNTQSSRHHNNSAPNLPLASHSKPQVRNFEESMNNPLPPLPPLPDLDNMRKTDKRAPKKSYSANDLHMARSSREYNYYKDNQKFYDGFIPEKRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQNANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNLNLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVKGNTKPGLVDVELAELNIEYIDKMTWKRCIRDGTMTLDSWAQTTFSARYSTVLEKLRGIYIFCTEMFALTDDNGTSDFSAEPQNLEKILYRKHCTPYELTWLFKKLANSLGITCEIVIGFLKTPSAINWEFKYNHCWLRILVNKEWRFIDVILGNVTNPIHEFVNNRKIKKAENSYFLMAPLEMIYTHIPPREFEQHIVPSIDQLSALYLPLVFPSFFKNELKLYKFSTALSFLEDSEIYECSLEIPNDVEVFASVVIPTDNEEASSAYRNMELALTQIKKQKAESGRRIALIKAVLPPNVNKGSLYIHSGVRGTQTSIANIHPLSMMVPLTHKGSNMKYEFVIKIPSESIQKIELYIVEPQSRYLFVGNEYSFEVIQSPSDGIVYSSDEGPNQNRKQPMAIKSPSGRVHELVKSDPHFPYGTWKGSIKIKEPGVWSALVIADSGIGWSVFAEWLCV
SIO_010081: YDL117W
subclass of: SO_0000673
so part of: YDL117W
location: 248581..251238
location: region:248581-251238:1
so has part: feature:248581-251238:1:exon

NP_010166.1
type: Protein
SIO_000068: ncbiprotein

S000002275
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248581-251238:1:exon

YDL116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUP84
locus tag: YDL116W
so part of: sequence
location: <251566..>253746
location: region:251566-253746:1
so has part: feature:251566-253746:1:exon
subclass of: SO_0000010

851441
type: Gene
SIO_000068: ncbigene

position:251566:1
position: 251566
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253746:1
position: 253746
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251566-253746:1:exon

YDL116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUP84
locus tag: YDL116W
product: Nup84p
transcript id: NM_001180175.1
SIO_010081: YDL116W
subclass of: SO_0000673
so part of: YDL116W
location: <251566..>253746
location: region:251566-253746:1
so has part: feature:251566-253746:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251566-253746:1:exon

YDL116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUP84
locus tag: YDL116W
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21818277]
experiment: EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]
experiment: EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15725626]
experiment: EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16418532|PMID:17538013]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8565072]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22110603]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:8565072]
note: Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107
codon start: 1
product: Nup84p
translation: MELSPTYQTERFTKFSDTLKEFKIEQNNEQNPIDPFNIIREFRSAAGQLALDLANSGDESNVISSKDWELEARFWHLVELLLVFRNADLDLDEMELHPYNSRGLFEKKLMQDNKQLYQIWIVMVWLKENTYVMERPKNVPTSKWLNSITSGGLKSCDLDFPLRENTNVLDVKDKEEDHIFFKYIYELILAGAIDEALEEAKLSDNISICMILCGIQEYLNPVIDTQIANEFNTQQGIKKHSLWRRTVYSLSQQAGLDPYERAIYSYLSGAIPNQEVLQYSDWESDLHIHLNQILQTEIENYLLENNQVGTDELILPLPSHALTVQEVLNRVASRHPSESEHPIRVLMASVILDSLPSVIHSSVEMLLDVVKGTEASNDIIDKPYLLRIVTHLAICLDIINPGSVEEVDKSKLITTYISLLKLQGLYENIPIYATFLNESDCLEACSFILSSLEDPQVRKKQIETINFLRLPASNILRRTTQRVFDETEQEYSPSNEISISFDVNNIDMHLIYGVEWLIEGKLYVDAVHSIIALSRRFLLNGRVKALEQFMERNNIGEICKNYELEKIADNISKDENEDQFLEEITQYEHLIKGIREYEEWQKSVSLLSSESNIPTLIEKLQGFSKDTFELIKTFLVDLTSSNFADSADYEILYEIRALYTPFLLMELHKKLVEAAKLLKIPKFISEALAFTSLVANENDKIYLLFQSSGKLKEYLDLVARTATLSN
SIO_010081: YDL116W
subclass of: SO_0000673
so part of: YDL116W
location: 251566..253746
location: region:251566-253746:1
so has part: feature:251566-253746:1:exon

NP_010167.1
type: Protein
SIO_000068: ncbiprotein

S000002274
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251566-253746:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS410; Autonomously Replicating Sequence
so part of: sequence
location: 253791..254039
location: region:253791-254039:1
so has part: feature:253791-254039:1:region

S000118431
type: SGD
SIO_000068: sgd

position:253791:1
position: 253791
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:254039:1
position: 254039
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253791-254039:1:region

YDL115C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IWR1
locus tag: YDL115C
so part of: sequence
location: complement(<253995..>255126)
location: region:253995-255126:-1
so has part: feature:253995-255126:-1:exon
subclass of: SO_0000010

851442
type: Gene
SIO_000068: ncbigene

position:253995:-1
position: 253995
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255126:-1
position: 255126
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253995-255126:-1:exon

YDL115C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IWR1
locus tag: YDL115C
product: Iwr1p
transcript id: NM_001180174.1
SIO_010081: YDL115C
subclass of: SO_0000673
so part of: YDL115C
location: complement(join(<253995..254974,255045..>255126))
location: region:253995-255126:-1
so has part: feature:255045-255126:-1:exon
so has part: feature:253995-254974:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255045-255126:-1:exon

position:255045:-1
position: 255045
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:253995-254974:-1:exon

position:254974:-1
position: 254974
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDL115C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IWR1
locus tag: YDL115C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21504834|PMID:19679657|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21504834|PMID:19679657|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:21504834|PMID:23267056]
experiment: EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:21504834]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:21504834]
note: RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: Iwr1p
translation: MSTISTTTAPEFIRVKRRRDEDSVQALLIDEGKRVKKQKFIFKLSKTVSSESYQSEQESSTPLLKLAHEDHRHFVLEQRKKSRRDSDDEKSQQRLAAEGSTVDDDGLPPEINQMVNDYLKLNKGVEKTERKKPSRKYFTGDSAKIASLPSLDYVFDIYHLEKIHDDEVARYNNEKNIGFVKIIEHIDLALDEESDPNEARSDDEDSNDENYYQNDYPEDEDDDRSILFGSEGEDIAALGEEIVIGVNKSRFSSWNDDKIQGSNGYHDVEEEYGDLFNRLGGKSDVLKSINSSNFIDLDGQEGEIEISDNEDDSDEGDDIEYPRNEFFPTDVDDPLAHHRDRIFHQLQKKINRS
SIO_010081: YDL115C
subclass of: SO_0000673
so part of: YDL115C
location: complement(join(253995..254974,255045..255126))
location: region:253995-255126:-1
so has part: feature:255045-255126:-1:exon
so has part: feature:253995-254974:-1:exon

NP_010168.4
type: Protein
SIO_000068: ncbiprotein

S000002273
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255045-255126:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:253995-254974:-1:exon

YDL114W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL114W
so part of: sequence
location: <255604..>256530
location: region:255604-256530:1
so has part: feature:255604-256530:1:exon
subclass of: SO_0000010

851444
type: Gene
SIO_000068: ncbigene

position:255604:1
position: 255604
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:256530:1
position: 256530
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:255604-256530:1:exon

YDL114W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL114W
product: short-chain dehydrogenase/reductase
transcript id: NM_001180173.1
SIO_010081: YDL114W
subclass of: SO_0000673
so part of: YDL114W
location: <255604..>256530
location: region:255604-256530:1
so has part: feature:255604-256530:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255604-256530:1:exon

YDL114W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL114W
note: Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene
codon start: 1
product: short-chain dehydrogenase/reductase
translation: MVRKNKINRASGTTKHLKDFPSVILSLPSYNPSILSKNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIFYYQCDITSLDEIKNLKKAIERDHGNINIIINNAGVAHIKKLEHMTNKEVEQLIDINLIGAYRIISTFAEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECNKTGIKTLLVCPGKIKTNMFIDVPTPSKLLAPDIIPSQLALAIISAMEHNHLQTLNAPYYVNLVPFFKTLSWPYRHLLKHFSGMDHVTSTSPRAINPKRSA
SIO_010081: YDL114W
subclass of: SO_0000673
so part of: YDL114W
location: 255604..256530
location: region:255604-256530:1
so has part: feature:255604-256530:1:exon

NP_010169.1
type: Protein
SIO_000068: ncbiprotein

S000002272
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255604-256530:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS411; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 256530..256633
location: region:256530-256633:1
so has part: feature:256530-256633:1:region

S000130171
type: SGD
SIO_000068: sgd

position:256633:1
position: 256633
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256530-256633:1:region

YDL113C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CVT20
alternative label: SNX42
gene: ATG20
locus tag: YDL113C
gene synonym: CVT20; SNX42
so part of: sequence
location: complement(<256633..>258555)
location: region:256633-258555:-1
so has part: feature:256633-258555:-1:exon
subclass of: SO_0000010

851445
type: Gene
SIO_000068: ncbigene

position:256633:-1
position: 256633
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:258555:-1
position: 258555
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256633-258555:-1:exon

YDL113C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CVT20
alternative label: SNX42
gene: ATG20
locus tag: YDL113C
gene synonym: CVT20; SNX42
product: Atg20p
transcript id: NM_001180172.1
SIO_010081: YDL113C
subclass of: SO_0000673
so part of: YDL113C
location: complement(<256633..>258555)
location: region:256633-258555:-1
so has part: feature:256633-258555:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256633-258555:-1:exon

YDL113C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CVT20
alternative label: SNX42
gene: ATG20
locus tag: YDL113C
gene synonym: CVT20; SNX42
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:12048214|PMID:15659643|PMID:18497569]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:12554655]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:12048214|PMID:11557775]
experiment: EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:12048214]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:12554655]
experiment: EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:12554655]
experiment: EXISTENCE:physical interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]
note: Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway, endosomal sorting and selective autophagy; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
codon start: 1
product: Atg20p
translation: MSDLNDVQENAKLNSETRNTGKAEPPHGTTEYVAEAEISKNGVGSPKKSPKKGKVGKGDNNKVETELVHTALLEKDNPFMEEGPTGFTKSALLEIPGMRSHNLKNPNEDYEDDSEGLLPLNQESNAETCRTSLSGSINSMNGETSASEEPSVSNRKKSARIHILEAKRVSEGQGRAYIAYVIQFENSTVQRRYSDFESLRSILIRLFPMTLIPPIPEKQSIKNYGKSITGSSSKYLLPSEGSGSVDLSLSVIHASVNNSDEKLIRHRIRMLTEFLNKLLTNEEITKTSIITDFLDPNNHNWHEFVNSSSTFSSLPKSILQCNPLDPTNTTRIHAMLPIPGSSSQLLLNKESNDKKMDKERSKSFTNIEQDYKQYENLLDNGIYKYNRRTTKTYHDLKSDYNEIGEVFAQFAHEQAQVGELAEQLSYLSNAFSGSSISLEKLVGRLYYNINEPLNESVHMATSARELIKYRKLKYLQNEMIKKSLNSKRAQLEKLEAQNNEYKDVDKIIDNEMSKSHTINLERPNNNTGSGGKSYGGKLFNGFNKLASMVKDSVKYQETDPHTASINLKKEIEQLSESLEVTENDLEVISKVIKNDQLPKFSKEREVDLSEILKHYSRYMRNYARQNLEIWKEVKRHQDFA
SIO_010081: YDL113C
subclass of: SO_0000673
so part of: YDL113C
location: complement(256633..258555)
location: region:256633-258555:-1
so has part: feature:256633-258555:-1:exon

NP_010170.1
type: Protein
SIO_000068: ncbiprotein

S000002271
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256633-258555:-1:exon

YDL112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRM3
locus tag: YDL112W
so part of: sequence
location: <258915..>263225
location: region:258915-263225:1
so has part: feature:258915-263225:1:exon
subclass of: SO_0000010

851446
type: Gene
SIO_000068: ncbigene

position:258915:1
position: 258915
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:263225:1
position: 263225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:258915-263225:1:exon

YDL112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRM3
locus tag: YDL112W
product: tRNA (guanosine(18)-2'-O)-methyltransferase
transcript id: NM_001180171.1
SIO_010081: YDL112W
subclass of: SO_0000673
so part of: YDL112W
location: <258915..>263225
location: region:258915-263225:1
so has part: feature:258915-263225:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:258915-263225:1:exon

YDL112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRM3
locus tag: YDL112W
EC number: 2.1.1.34
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016423 tRNA (guanine) methyltransferase activity [PMID:9917067]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:9917067]
experiment: EXISTENCE:mutant phenotype:GO:0002128 tRNA nucleoside ribose methylation [PMID:32053677]
note: 2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
codon start: 1
product: tRNA (guanosine(18)-2'-O)-methyltransferase
translation: MVGGALICKYLPREEQLKLISDLIQNDSLEEVLELIETSPLDITTDSNIETPIFEKITEQVIAYASIDGEAREMFRSSRAEMNKALRTSAQLLCCLPSVWHKFQVWMSYRLNDIISENYKHLFNDNFGKKIVQPFFDSFAEEQNANIKHENLHLDILSLLHYLEVVYLFDECKNGISSKCLDFIIVPLLGCNSEEIADSCSKLMRWHIKYLSKCCNTDSNFDKLIWTFIKQLYAEGSQQAWKQKNSLSFLLRFLLAAELSPELITYIKTDAYWRHIQTELDNDVHEHRKLALSILKLTIQKLSSHGITLQTTFYKCNDLANIEMLGSWKKFTTLYEMIALDTSLNQIQAAKQDIIKIFDNEHLHHSWGLILLSTGLKSSMESVRKYMMTLMFSITNMSAFSSNLPLLTKTLLPAAMSAHYFDVKGVSCPHGEKLSLFVNNLLSQTTEGISDILFEILKLLVEKGTSFDPSRIYLSYGILVFFQNNKQKTINSDHLSLIRKLYDFAAEEEVLETTIQTIYLKFLLYIDPSVSASELLFTLVSHIKLKGGTYKYVEPLFEDYRDLAVSHFDDLQAKENLTTNIGKDTIFDLLASIIFDFKDIDITPDFLIEVAKSKQDIPVYTSKAVTFLTQLLSGEPSNGYTYENATALLSYPNFTISTWKSINVNNLFKSVMEKFSLDKFKFFAEIYQKTYECRFDTIELNFNDLLSLYEMVKKSANQCSRESFKVKDSAYSSYFELLNTFLKTYALNRDSSEGNDDELHILLRLVDENINKDNGNYLGNLAVCKLLYFIIDSYIHCSTSVSDDDIFIVKFIFEKFSFIWECINSERLVLKERDLHLMLIKGLFHPVILYFGSNQYIDTLTSKLEEHAQTIISLSYSRRSLLPLLGSQLRVFMKFYGKLLREDVNYWWLINIIVGVFKQPQMDVNLYKLKPVISSLFDHKLNNYYIKGDELYEKVYGPDEILARVSIIDSILYANDQLKIRLIEKVTEKTNALYAIKRTDGAEALQRLLQWQLLLLSLLTTNEKKLSETSMIRILKSIEDESSPLVRVYKEWFISSKVVDYYKTGNPKFAEDYLFSLLEDHSKPVFVVSAEKICFMVLKDLRNDEKKYGFTQLLDRFICTLVPNAASNKPLVRHFSNSLIISLWPTFKAYLSDHTLRNIIENLYSNAKKTQIFGQYRAGDANIWDLKGDRKLTNMFGGVLKKVTDHDCPYISESVFEKYLQEKDIVPIGTDERSLWLDKRDTNTESVNNANISCDTSPLQTKSGAWETVLDLDNKKSNDVVTRSELIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTADRWMPMEEVALDEIASFMKEKKKEGYTLIGLEQTDKSVKLDNNFQFPKKSLILLGTEAFGIPGTLLSELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQHM
SIO_010081: YDL112W
subclass of: SO_0000673
so part of: YDL112W
location: 258915..263225
location: region:258915-263225:1
so has part: feature:258915-263225:1:exon

NP_010171.1
type: Protein
SIO_000068: ncbiprotein

S000002270
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:258915-263225:1:exon

YDL111C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP42
locus tag: YDL111C
so part of: sequence
location: complement(<263313..>264110)
location: region:263313-264110:-1
so has part: feature:263313-264110:-1:exon
subclass of: SO_0000010

851447
type: Gene
SIO_000068: ncbigene

position:263313:-1
position: 263313
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:264110:-1
position: 264110
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263313-264110:-1:exon

YDL111C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP42
locus tag: YDL111C
product: exosome non-catalytic core subunit RRP42
transcript id: NM_001180170.1
SIO_010081: YDL111C
subclass of: SO_0000673
so part of: YDL111C
location: complement(<263313..>264110)
location: region:263313-264110:-1
so has part: feature:263313-264110:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:263313-264110:-1:exon

YDL111C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP42
locus tag: YDL111C
experiment: EXISTENCE:curator inference:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0043628 regulatory ncRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070651 nonfunctional rRNA decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:17643380]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:9390555]
experiment: EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:10508172]
note: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
codon start: 1
product: exosome non-catalytic core subunit RRP42
translation: MSLSVAEKSYLYDSLASTPSIRPDGRLPHQFRPIEIFTDFLPSSNGSSRIIASDGSECIVSIKSKVVDHHVENELLQVDVDIAGQRDDALVVETITSLLNKVLKSGSGVDSSKLQLTKKYSFKIFVDVLVISSHSHPVSLISFAIYSALNSTYLPKLISAFDDLEVEELPTFHDYDMVKLDINPPLVFILAVVGNNMLLDPAANESEVANNGLIISWSNGKITSPIRSVALNDSNVKSFKPHLLKQGLAMVEKYAPDVVRSLENL
SIO_010081: YDL111C
subclass of: SO_0000673
so part of: YDL111C
location: complement(263313..264110)
location: region:263313-264110:-1
so has part: feature:263313-264110:-1:exon

NP_010172.1
type: Protein
SIO_000068: ncbiprotein

S000002269
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:263313-264110:-1:exon

YDL110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ADC17
gene: TMA17
locus tag: YDL110C
gene synonym: ADC17
so part of: sequence
location: complement(<264512..>264964)
location: region:264512-264964:-1
so has part: feature:264512-264964:-1:exon
subclass of: SO_0000010

851448
type: Gene
SIO_000068: ncbigene

position:264512:-1
position: 264512
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:264964:-1
position: 264964
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264512-264964:-1:exon

YDL110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ADC17
gene: TMA17
locus tag: YDL110C
gene synonym: ADC17
product: Tma17p
transcript id: NM_001180169.1
SIO_010081: YDL110C
subclass of: SO_0000673
so part of: YDL110C
location: complement(<264512..>264964)
location: region:264512-264964:-1
so has part: feature:264512-264964:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264512-264964:-1:exon

YDL110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ADC17
gene: TMA17
locus tag: YDL110C
gene synonym: ADC17
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005835 fatty acid synthase complex [PMID:32160528]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:25042801]
experiment: EXISTENCE:direct assay:GO:0070682 proteasome regulatory particle assembly [PMID:25042801]
experiment: EXISTENCE:direct assay:GO:0098772 molecular function regulator activity [PMID:32160528]
experiment: EXISTENCE:mutant phenotype:GO:0006633 fatty acid biosynthetic process [PMID:32160528]
note: Regulatory gamma subunit of fatty acid synthase (FAS); ATPase dedicated chaperone that adapts proteasome assembly to stress; induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
codon start: 1
product: Tma17p
translation: MCSAGGIRRPIQIEEFKTAISGMSDMELAQIKTEIENSINHLQRSNARLGKYIAKLEGADDRLEADDSDDLENIDSGDLALYKDSVRENEIVLNNYNERVDALEQETVYRKTGHGKSKHEVEAKDNTNKGPDVDMDNSNVDVVTPNSIFI
SIO_010081: YDL110C
subclass of: SO_0000673
so part of: YDL110C
location: complement(264512..264964)
location: region:264512-264964:-1
so has part: feature:264512-264964:-1:exon

NP_010173.1
type: Protein
SIO_000068: ncbiprotein

S000002268
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264512-264964:-1:exon

YDL109C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL109C
so part of: sequence
location: complement(<265258..>267201)
location: region:265258-267201:-1
so has part: feature:265258-267201:-1:exon
subclass of: SO_0000010

851449
type: Gene
SIO_000068: ncbigene

position:265258:-1
position: 265258
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:267201:-1
position: 267201
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:265258-267201:-1:exon

YDL109C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL109C
product: putative lipase
transcript id: NM_001180168.1
SIO_010081: YDL109C
subclass of: SO_0000673
so part of: YDL109C
location: complement(<265258..>267201)
location: region:265258-267201:-1
so has part: feature:265258-267201:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:265258-267201:-1:exon

YDL109C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL109C
note: Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
codon start: 1
product: putative lipase
translation: MEAGRSADEVLYHNQSSVKLGELERYVITYELYQGDSIPADITLDSLWVKIKNTTKLSYKPAYLLGPFILYCDVRAKDYESSYKIICSADKPVFQSNLQAQQKFIAELSLHHIKPRYVWIVDIVSQILFNKETKVTFEIVVGNSKASLKRKIRCNDSLPDKACNILHTGLSVHRLTTADIWKVPRPIDMSQKSHLVILTHGFQSNVSADMEYLMEEIYKAQMNNPNERLVIKGYMKNACETEKGIKFLGVGLANYIIDELYDDSVGKISFIGHSLGGLTQTFAICYIKTKYPYFFKKVEPINFISLASPLLGIATSTPNYVKMSLSMGIIGTTGQELGLKDGNYGDKPLLYLLSEESLISVLARFKRRTLYANAVNDGIVPLYSSSLLFLDYSQLLQKLGGQTTAPCDPLFQPEVSPIGELPNHSDVANDDDGINASSWNTFWKSKENNCDKKSKRLMNASVIKSMKSVLLSPCPDAKFFSDPDARVATIIHDKIYTEKNLPPPSPTLYEGTAAKEGETRKTRKEMEEIIARRWHKGMHWRKVVVLLKPDAHNNIIVRRRFSNAYGWPVVDHLVTAHFQRDDPIASPMQDKQFAEEDINMATGGVEPNKFYSWLTKIEDPSVYHGGIVSTASQLASSWISKHSSVTD
SIO_010081: YDL109C
subclass of: SO_0000673
so part of: YDL109C
location: complement(265258..267201)
location: region:265258-267201:-1
so has part: feature:265258-267201:-1:exon

NP_010174.1
type: Protein
SIO_000068: ncbiprotein

S000002267
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:265258-267201:-1:exon

YDL108W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KIN28
locus tag: YDL108W
so part of: sequence
location: <267698..>268699
location: region:267698-268699:1
so has part: feature:267698-268699:1:exon
subclass of: SO_0000010

851450
type: Gene
SIO_000068: ncbigene

position:267698:1
position: 267698
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:268699:1
position: 268699
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267698-268699:1:exon

YDL108W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KIN28
locus tag: YDL108W
product: TFIIH complex serine/threonine-protein kinase subunit KIN28
transcript id: NM_001180167.1
SIO_010081: YDL108W
subclass of: SO_0000673
so part of: YDL108W
location: join(<267698..267725,267807..>268699)
location: region:267698-268699:1
so has part: feature:267698-267725:1:exon
so has part: feature:267807-268699:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267698-267725:1:exon

position:267725:1
position: 267725
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:267807-268699:1:exon

position:267807:1
position: 267807
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL108W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KIN28
locus tag: YDL108W
EC number: 2.7.11.23
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:7760796|PMID:9702190]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14749387]
experiment: EXISTENCE:direct assay:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:11839796|PMID:19450536|PMID:19679665|PMID:7760796|PM ID:9702190]
experiment: EXISTENCE:direct assay:GO:0070985 transcription factor TFIIK complex [PMID:11839796|PMID:19818408]
experiment: EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:12015980]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:7760796|PMID:7783209]
experiment: EXISTENCE:mutant phenotype:GO:0006370 7-methylguanosine mRNA capping [PMID:22689984]
experiment: EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26567215]
experiment: EXISTENCE:mutant phenotype:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:9702190]
experiment: EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:26567215]
experiment: EXISTENCE:mutant phenotype:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:9702190]
experiment: EXISTENCE:mutant phenotype:GO:1900018 phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [PMID:10594013|PMID:19666497]
experiment: EXISTENCE:mutant phenotype:GO:1901921 phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [PMID:10594013]
experiment: EXISTENCE:mutant phenotype:GO:1903654 phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter [PMID:27477907]
experiment: EXISTENCE:mutant phenotype:GO:1905866 positive regulation of Atg1/ULK1 kinase complex assembly [PMID:26567215]
experiment: EXISTENCE:physical interaction:GO:1901921 phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [PMID:10594013]
note: Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7
codon start: 1
product: TFIIH complex serine/threonine-protein kinase subunit KIN28
translation: MKVNMEYTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSIKIRN
SIO_010081: YDL108W
subclass of: SO_0000673
so part of: YDL108W
location: join(267698..267725,267807..268699)
location: region:267698-268699:1
so has part: feature:267698-267725:1:exon
so has part: feature:267807-268699:1:exon

NP_010175.1
type: Protein
SIO_000068: ncbiprotein

S000002266
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267698-267725:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:267807-268699:1:exon

YDL107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSS2
locus tag: YDL107W
so part of: sequence
location: <268921..>269976
location: region:268921-269976:1
so has part: feature:268921-269976:1:exon
subclass of: SO_0000010

851451
type: Gene
SIO_000068: ncbigene

position:268921:1
position: 268921
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:269976:1
position: 269976
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268921-269976:1:exon

YDL107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSS2
locus tag: YDL107W
product: Mss2p
transcript id: NM_001180166.1
SIO_010081: YDL107W
subclass of: SO_0000673
so part of: YDL107W
location: <268921..>269976
location: region:268921-269976:1
so has part: feature:268921-269976:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:268921-269976:1:exon

YDL107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSS2
locus tag: YDL107W
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11604502]
experiment: EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926]
experiment: EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11604502]
experiment: EXISTENCE:physical interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926|PMID:17452441]
note: Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
codon start: 1
product: Mss2p
translation: MQRFVSKFVSTPPVPKKFQEIFPKKRTVNKILFQLDTRLTYHEMYPIFLQVSQNTNEENIPWRKKYPYIRSSDIMQMRNVLITLRTQNKFVHKDLLAMEDKLLNIAAELGNNDAISILSFNVIHEYKKENVKSSYEKDIETANEFIKKLYARNHHLTVKLIGDLFFENKTYDKAEKYYQEFLKLENSTKLAGEVHGKLGEIQIKQVNGFLKAEKSWLSCIELLEIERSSRWYFLLARLYMSSEPMKAKALLENCASIGFKECFKTLGFLELNYFNNYERAKEWFKTGMEIMDLECFFGFFDCCVKEENFKGARDCLESVKKLGNDKDKKTMINVFLESRKDSIKLLDKARL
SIO_010081: YDL107W
subclass of: SO_0000673
so part of: YDL107W
location: 268921..269976
location: region:268921-269976:1
so has part: feature:268921-269976:1:exon

NP_010176.1
type: Protein
SIO_000068: ncbiprotein

S000002265
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:268921-269976:1:exon

YDL106C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BAS2
alternative label: GRF10
gene: PHO2
locus tag: YDL106C
gene synonym: BAS2; GRF10
so part of: sequence
location: complement(<270222..>271901)
location: region:270222-271901:-1
so has part: feature:270222-271901:-1:exon
subclass of: SO_0000010

851452
type: Gene
SIO_000068: ncbigene

position:270222:-1
position: 270222
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271901:-1
position: 271901
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:270222-271901:-1:exon

YDL106C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BAS2
alternative label: GRF10
gene: PHO2
locus tag: YDL106C
gene synonym: BAS2; GRF10
product: Pho2p
transcript id: NM_001180165.1
SIO_010081: YDL106C
subclass of: SO_0000673
so part of: YDL106C
location: complement(<270222..>271901)
location: region:270222-271901:-1
so has part: feature:270222-271901:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270222-271901:-1:exon

YDL106C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BAS2
alternative label: GRF10
gene: PHO2
locus tag: YDL106C
gene synonym: BAS2; GRF10
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:2664469]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3303332|PMID:9566882|PMID:7902583]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1493793|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006141 regulation of purine nucleobase metabolic process [PMID:1495962]
experiment: EXISTENCE:direct assay:GO:0043388 positive regulation of DNA binding [PMID:8355698]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:genetic interaction:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9566882|PMID:7902583]
experiment: EXISTENCE:genetic interaction:GO:0045937 positive regulation of phosphate metabolic process [PMID:3915785]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3915785|PMID:7902583]
experiment: EXISTENCE:genetic interaction:GO:0120213 regulation of histidine biosynthetic process [PMID:3303332]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3303332|PMID:7902583|PMID:9566882]
experiment: EXISTENCE:mutant phenotype:GO:0006141 regulation of purine nucleobase metabolic process [PMID:1495962]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:2196175]
experiment: EXISTENCE:mutant phenotype:GO:0043388 positive regulation of DNA binding [PMID:7902583]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3303332|PMID:7902583]
experiment: EXISTENCE:mutant phenotype:GO:0120213 regulation of histidine biosynthetic process [PMID:3303332]
experiment: EXISTENCE:mutant phenotype:GO:2000679 positive regulation of transcription regulatory region DNA binding [PMID:9354395]
note: Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Pho2p
translation: MMEEFSYDHDFNTHFATDLDYLQHDQQQQQQQQHDQQHNQQQQPQPQPIQTQNLEHDHDQHTNDMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQHGSNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSSIFHDEDLTFFDRIPLNSNNNYYFFDICSITVGSWNRMKSGALQRRNFQSIKELRNLSPIKINNIMSNATDLMVLISKKNSEINYFFSAMANNTKILFRIFFPLSSVTNCSLTLETDDDIINSNNTSDKNNSNTNNDDDNDDNSNEDNDNSSEDKRNAKDNFGELKLTVTRSPTFAVYFLNNAPDEDPNLNNQWSICDDFSEGRQVNDAFVGGSNIPHTLKGLQKSLRFMNSLILDYKSSNEILPTINTAIPTAAVPQQNIAPPFLNTNSSATDSNPNTNLEDSLFFDHDLLSSSITNTNNGQGSNNGRQASKDDTLNLLDTTVNSNNNHNANNEENHLAQEHLSNDADIVANPNDHLLSLPTDSELPNTPDFLKNTNELTDEHRWI
SIO_010081: YDL106C
subclass of: SO_0000673
so part of: YDL106C
location: complement(270222..271901)
location: region:270222-271901:-1
so has part: feature:270222-271901:-1:exon

NP_010177.1
type: Protein
SIO_000068: ncbiprotein

S000002264
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270222-271901:-1:exon

YDL105W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: QRI2
gene: NSE4
locus tag: YDL105W
gene synonym: QRI2
so part of: sequence
location: <272389..>273597
location: region:272389-273597:1
so has part: feature:272389-273597:1:exon
subclass of: SO_0000010

851453
type: Gene
SIO_000068: ncbigene

position:272389:1
position: 272389
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273597:1
position: 273597
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272389-273597:1:exon

YDL105W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: QRI2
gene: NSE4
locus tag: YDL105W
gene synonym: QRI2
product: Smc5-Smc6 complex subunit NSE4
transcript id: NM_001180164.1
SIO_010081: YDL105W
subclass of: SO_0000673
so part of: YDL105W
location: <272389..>273597
location: region:272389-273597:1
so has part: feature:272389-273597:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272389-273597:1:exon

YDL105W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: QRI2
gene: NSE4
locus tag: YDL105W
gene synonym: QRI2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391|PMID:15752197]
note: Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
codon start: 1
product: Smc5-Smc6 complex subunit NSE4
translation: MSSTVISRKRRNSTVTEPDSSGETRKQKKSRSDEKSSSSKDGDPQLEFKVLQGYRDLESEMHKGRAQVTRTGDIGVAMDNLNAVDSLFNKVIGIKNNGLFAHDARAMVSISELAQISVRNLKFDDSRSMVNLENIVNSLKRYMLKEHFKLNNIAENRNDLTLAADEQSAADQQEESDGDIDRTPDDNHTDKATSSFKATSMRHSYLQQFSHYNEFSQFNWFRIGALYNTISKNAPITDHLMGPLSIEKKPRVLTQRRRNNDQVGEKITAEKITQHSLNSTQQETTPEQVKKCFKKLSKKLGPEGSINLFKFIIDPNSFSRSIENLFYTSFLIKEGKLLMEHDEEGLPTIKIKQSISHTDSRSKEIERQRRRAAHQNHIIFQMDMPTWRKLIKKYNITSPFLD
SIO_010081: YDL105W
subclass of: SO_0000673
so part of: YDL105W
location: 272389..273597
location: region:272389-273597:1
so has part: feature:272389-273597:1:exon

NP_010178.1
type: Protein
SIO_000068: ncbiprotein

S000002263
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272389-273597:1:exon

YDL104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: QRI7
locus tag: YDL104C
so part of: sequence
location: complement(<273653..>274876)
location: region:273653-274876:-1
so has part: feature:273653-274876:-1:exon
subclass of: SO_0000010

851454
type: Gene
SIO_000068: ncbigene

position:273653:-1
position: 273653
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:274876:-1
position: 274876
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:273653-274876:-1:exon

YDL104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: QRI7
locus tag: YDL104C
product: putative N(6)-L-threonylcarbamoyladenine synthase
transcript id: NM_001180163.1
SIO_010081: YDL104C
subclass of: SO_0000673
so part of: YDL104C
location: complement(<273653..>274876)
location: region:273653-274876:-1
so has part: feature:273653-274876:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:273653-274876:-1:exon

YDL104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: QRI7
locus tag: YDL104C
EC number: 2.3.1.234
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:33277478]
experiment: EXISTENCE:direct assay:GO:0002949 tRNA threonylcarbamoyladenosine modification [PMID:23620299]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity [PMID:23620299]
experiment: EXISTENCE:mutant phenotype:GO:0072670 mitochondrial tRNA threonylcarbamoyladenosine modification [PMID:21183954]
note: Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex
codon start: 1
product: putative N(6)-L-threonylcarbamoyladenine synthase
translation: MISIKGTGRFLLDNYRIWQRRAFNRPIQLRKGYKVLAIETSCDDTCVSVLDRFSKSAAPNVLANLKDTLDSIDEGGIIPTKAHIHHQARIGPLTERALIESNAREGIDLICVTRGPGMPGSLSGGLDFAKGLAVAWNKPLIGVHHMLGHLLIPRMGTNGKVPQFPFVSLLVSGGHTTFVLSRAIDDHEILCDTIDIAVGDSLDKCGRELGFKGTMIAREMEKFINQDINDQDFALKLEMPSPLKNSASKRNMLSFSFSAFITALRTNLTKLGKTEIQELPEREIRSIAYQVQESVFDHIINKLKHVLKSQPEKFKNVREFVCSGGVSSNQRLRTKLETELGTLNSTSFFNFYYPPMDLCSDNSIMIGWAGIEIWESLRLVSDLDICPIRQWPLNDLLSVDGWRTDQL
SIO_010081: YDL104C
subclass of: SO_0000673
so part of: YDL104C
location: complement(273653..274876)
location: region:273653-274876:-1
so has part: feature:273653-274876:-1:exon

NP_010179.1
type: Protein
SIO_000068: ncbiprotein

S000002262
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:273653-274876:-1:exon

YDL103C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UAP1
gene: QRI1
locus tag: YDL103C
gene synonym: UAP1
so part of: sequence
location: complement(<275148..>276581)
location: region:275148-276581:-1
so has part: feature:275148-276581:-1:exon
subclass of: SO_0000010

851455
type: Gene
SIO_000068: ncbigene

position:275148:-1
position: 275148
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276581:-1
position: 276581
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:275148-276581:-1:exon

YDL103C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UAP1
gene: QRI1
locus tag: YDL103C
gene synonym: UAP1
product: UDP-N-acetylglucosamine diphosphorylase
transcript id: NM_001180162.1
SIO_010081: YDL103C
subclass of: SO_0000673
so part of: YDL103C
location: complement(<275148..>276581)
location: region:275148-276581:-1
so has part: feature:275148-276581:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:275148-276581:-1:exon

YDL103C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UAP1
gene: QRI1
locus tag: YDL103C
gene synonym: UAP1
EC number: 2.7.7.23
experiment: EXISTENCE:direct assay:GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity [PMID:9603950]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006048 UDP-N-acetylglucosamine biosynthetic process [PMID:9603950]
note: UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
codon start: 1
product: UDP-N-acetylglucosamine diphosphorylase
translation: MTDTKQLFIEAGQSQLFHNWESLSRKDQEELLSNLEQISSKRSPAKLLEDCQNAIKFSLANSSKDTGVEISPLPPTSYESLIGNSKKENEYWRLGLEAIGKGEVAVILMAGGQGTRLGSSQPKGCYDIGLPSKKSLFQIQAEKLIRLQDMVKDKKVEIPWYIMTSGPTRAATEAYFQEHNYFGLNKEQITFFNQGTLPAFDLTGKHFLMKDPVNLSQSPDGNGGLYRAIKENKLNEDFDRRGIKHVYMYCVDNVLSKIADPVFIGFAIKHGFELATKAVRKRDAHESVGLIATKNEKPCVIEYSEISNELAEAKDKDGLLKLRAGNIVNHYYLVDLLKRDLDQWCENMPYHIAKKKIPAYDSVTGKYTKPTEPNGIKLEQFIFDVFDTVPLNKFGCLEVDRCKEFSPLKNGPGSKNDNPETSRLAYLKLGTSWLEDAGAIVKDGVLVEVSSKLSYAGENLSQFKGKVFDRSGIVLEK
SIO_010081: YDL103C
subclass of: SO_0000673
so part of: YDL103C
location: complement(275148..276581)
location: region:275148-276581:-1
so has part: feature:275148-276581:-1:exon

NP_010180.1
type: Protein
SIO_000068: ncbiprotein

S000002261
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:275148-276581:-1:exon

YDL102W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDC2
alternative label: HPR6
alternative label: TEX1
gene: POL3
locus tag: YDL102W
gene synonym: CDC2; HPR6; TEX1
so part of: sequence
location: <276872..>280165
location: region:276872-280165:1
so has part: feature:276872-280165:1:exon
subclass of: SO_0000010

851456
type: Gene
SIO_000068: ncbigene

position:276872:1
position: 276872
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280165:1
position: 280165
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:276872-280165:1:exon

YDL102W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDC2
alternative label: HPR6
alternative label: TEX1
gene: POL3
locus tag: YDL102W
gene synonym: CDC2; HPR6; TEX1
product: DNA-directed DNA polymerase delta POL3
transcript id: NM_001180161.2
SIO_010081: YDL102W
subclass of: SO_0000673
so part of: YDL102W
location: <276872..>280165
location: region:276872-280165:1
so has part: feature:276872-280165:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:276872-280165:1:exon

YDL102W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDC2
alternative label: HPR6
alternative label: TEX1
gene: POL3
locus tag: YDL102W
gene synonym: CDC2; HPR6; TEX1
EC number: 2.7.7.7
experiment: EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:1678279|PMID:18635534]
experiment: EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893]
experiment: EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]
experiment: EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]
experiment: EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18606574]
experiment: EXISTENCE:genetic interaction:GO:0045005 DNA-templated DNA replication maintenance of fidelity [PMID:15601866]
experiment: EXISTENCE:mutant phenotype:GO:0003887 DNA-directed DNA polymerase activity [PMID:1678279]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:1678279]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18606574]
experiment: EXISTENCE:mutant phenotype:GO:0008296 3'-5'-exodeoxyribonuclease activity [PMID:1648480]
experiment: EXISTENCE:mutant phenotype:GO:0045004 DNA replication proofreading [PMID:32123096]
note: Catalytic subunit of DNA polymerase delta; responsible for most of lagging strand DNA synthesis; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
codon start: 1
product: DNA-directed DNA polymerase delta POL3
translation: MSEKRSLPMVDVKIDDEDTPQLEKKIKRQSIDHGVGSEPVSTIEIIPSDSFRKYNSQGFKAKDTDLMGTQLESTFEQELSQMEHDMADQEEHDLSSFERKKLPTDFDPSLYDISFQQIDAEQSVLNGIKDENTSTVVRFFGVTSEGHSVLCNVTGFKNYLYVPAPNSSDANDQEQINKFVHYLNETFDHAIDSIEVVSKQSIWGYSGDTKLPFWKIYVTYPHMVNKLRTAFERGHLSFNSWFSNGTTTYDNIAYTLRLMVDCGIVGMSWITLPKGKYSMIEPNNRVSSCQLEVSINYRNLIAHPAEGDWSHTAPLRIMSFDIECAGRIGVFPEPEYDPVIQIANVVSIAGAKKPFIRNVFTLNTCSPITGSMIFSHATEEEMLSNWRNFIIKVDPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEIKESVFSSKAYGTRETKNVNIDGRLQLDLLQFIQREYKLRSYTLNAVSAHFLGEQKEDVHYSIISDLQNGDSETRRRLAVYCLKDAYLPLRLMEKLMALVNYTEMARVTGVPFSYLLARGQQIKVVSQLFRKCLEIDTVIPNMQSQASDDQYEGATVIEPIRGYYDVPIATLDFNSLYPSIMMAHNLCYTTLCNKATVERLNLKIDEDYVITPNGDYFVTTKRRRGILPIILDELISARKRAKKDLRDEKDPFKRDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAYGRTMILKTKTAVQEKYCIKNGYKHDAVVVYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVSTLFKHPINLEFEKAYFPYLLINKKRYAGLFWTNPDKFDKLDQKGLASVRRDSCSLVSIVMNKVLKKILIERNVDGALAFVRETINDILHNRVDISKLIISKTLAPNYTNPQPHAVLAERMKRREGVGPNVGDRVDYVIIGGNDKLYNRAEDPLFVLENNIQVDSRYYLTNQLQNPIISIVAPIIGDKQANGMFVVKSIKINTGSQKGGLMSFIKKVEACKSCKGPLRKGEGPLCSNCLARSGELYIKALYDVRDLEEKYSRLWTQCQRCAGNLHSEVLCSNKNCDIFYMRVKVKKELQEKVEQLSKW
SIO_010081: YDL102W
subclass of: SO_0000673
so part of: YDL102W
location: 276872..280165
location: region:276872-280165:1
so has part: feature:276872-280165:1:exon

NP_010181.2
type: Protein
SIO_000068: ncbiprotein

S000002260
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:276872-280165:1:exon

YDL101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DUN1
locus tag: YDL101C
so part of: sequence
location: complement(<280307..>281848)
location: region:280307-281848:-1
so has part: feature:280307-281848:-1:exon
subclass of: SO_0000010

851457
type: Gene
SIO_000068: ncbigene

position:280307:-1
position: 280307
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:281848:-1
position: 281848
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280307-281848:-1:exon

YDL101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DUN1
locus tag: YDL101C
product: serine/threonine protein kinase DUN1
transcript id: NM_001180160.1
SIO_010081: YDL101C
subclass of: SO_0000673
so part of: YDL101C
location: complement(<280307..>281848)
location: region:280307-281848:-1
so has part: feature:280307-281848:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280307-281848:-1:exon

YDL101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DUN1
locus tag: YDL101C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11904430|PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:24647101]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791]
experiment: EXISTENCE:genetic interaction:GO:0048478 replication fork protection [PMID:17158920]
experiment: EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:11904430]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:24647101]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791]
note: Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role
codon start: 1
product: serine/threonine protein kinase DUN1
translation: MSLSTKREHSGDVTDSSFKRQQRSNKPSSEYTCLGHLVNLIPGKEQKVEITNRNVTTIGRSRSCDVILSEPDISTFHAEFHLLQMDVDNFQRNLINVIDKSRNGTFINGNRLVKKDYILKNGDRIVFGKSCSFLFKYASSSSTDIENDDEKVSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVSLELQRLQITDNKIPKTYSELSCL
SIO_010081: YDL101C
subclass of: SO_0000673
so part of: YDL101C
location: complement(280307..281848)
location: region:280307-281848:-1
so has part: feature:280307-281848:-1:exon

NP_010182.1
type: Protein
SIO_000068: ncbiprotein

S000002259
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280307-281848:-1:exon

YDL100C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARR4
gene: GET3
locus tag: YDL100C
gene synonym: ARR4
so part of: sequence
location: complement(<282112..>283176)
location: region:282112-283176:-1
so has part: feature:282112-283176:-1:exon
subclass of: SO_0000010

851458
type: Gene
SIO_000068: ncbigene

position:282112:-1
position: 282112
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:283176:-1
position: 283176
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282112-283176:-1:exon

YDL100C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARR4
gene: GET3
locus tag: YDL100C
gene synonym: ARR4
product: guanine nucleotide exchange factor GET3
transcript id: NM_001180159.1
SIO_010081: YDL100C
subclass of: SO_0000673
so part of: YDL100C
location: complement(<282112..>283176)
location: region:282112-283176:-1
so has part: feature:282112-283176:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282112-283176:-1:exon

YDL100C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARR4
gene: GET3
locus tag: YDL100C
gene synonym: ARR4
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:18261907]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]
experiment: EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12680698]
experiment: EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:25242142]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:25242142]
experiment: EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:18261907]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:12680698]
experiment: EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:12680698]
experiment: EXISTENCE:mutant phenotype:GO:0045048 protein insertion into ER membrane [PMID:18724936]
experiment: EXISTENCE:physical interaction:GO:0043529 GET complex [PMID:16269340]
note: Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into ER membrane under non-stress conditions; binds as dimer to transmembrane domain (TMD) cargo, shielding TMDs from aqueous solvent; protein abundance increases under DNA replication stress
codon start: 1
product: guanine nucleotide exchange factor GET3
translation: MDLTVEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSLLQGGALADLTGSIPGIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITNKLGPMLNSFMGAGNVDISGKLNELKANVETIRQQFTDPDLTTFVCVCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRGLNNLTKFSQFLNKEYNPITDGKVIYELEDKE
SIO_010081: YDL100C
subclass of: SO_0000673
so part of: YDL100C
location: complement(282112..283176)
location: region:282112-283176:-1
so has part: feature:282112-283176:-1:exon

NP_010183.1
type: Protein
SIO_000068: ncbiprotein

S000002258
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282112-283176:-1:exon

YDL099W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUG1
locus tag: YDL099W
so part of: sequence
location: <283419..>284444
location: region:283419-284444:1
so has part: feature:283419-284444:1:exon
subclass of: SO_0000010

851459
type: Gene
SIO_000068: ncbigene

position:283419:1
position: 283419
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:284444:1
position: 284444
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:283419-284444:1:exon

YDL099W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUG1
locus tag: YDL099W
product: Bug1p
transcript id: NM_001180158.1
SIO_010081: YDL099W
subclass of: SO_0000673
so part of: YDL099W
location: <283419..>284444
location: region:283419-284444:1
so has part: feature:283419-284444:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:283419-284444:1:exon

YDL099W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUG1
locus tag: YDL099W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:17261844]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17261844]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17261844]
experiment: EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:20156967]
experiment: EXISTENCE:physical interaction:GO:0005801 cis-Golgi network [PMID:17261844]
experiment: EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:16269340]
note: Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
codon start: 1
product: Bug1p
translation: MSEQESDEVKRMKQLEEARKRVEELKKKKNKKNKGKKNKNSSATGSIGSETPDLEGTPGEESTQEETVKANSTKSENNDQNDVDEESEEKEIEQVKSDPSGTTEKDIEEINSTSSNVGKDDAENTKKEEVQEVIKNNNDEQTADAGKTIEPQEEKKIVQTQEGNEPSNTSEAADDLFANDGNEESDFLTTIKKQKEEDELTKLRAENEKLTQENKQLKFLNMENETTVDDLQDQLQEKEDIINGLQNDLQTARDELIAAVEKLKLAEAKAARNTTATPIQFADFNTSSNNLTPSQSVTNSGTQVAHGNNMEVDRVMLNKWRQWNVDMTTWRSIGSGPIMEF
SIO_010081: YDL099W
subclass of: SO_0000673
so part of: YDL099W
location: 283419..284444
location: region:283419-284444:1
so has part: feature:283419-284444:1:exon

NP_010184.1
type: Protein
SIO_000068: ncbiprotein

S000002257
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:283419-284444:1:exon

YDL098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNU23
locus tag: YDL098C
so part of: sequence
location: complement(<284581..>285165)
location: region:284581-285165:-1
so has part: feature:284581-285165:-1:exon
subclass of: SO_0000010

851460
type: Gene
SIO_000068: ncbigene

position:284581:-1
position: 284581
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:285165:-1
position: 285165
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:284581-285165:-1:exon

YDL098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNU23
locus tag: YDL098C
product: U4/U6-U5 snRNP complex subunit SNU23
transcript id: NM_001180157.1
SIO_010081: YDL098C
subclass of: SO_0000673
so part of: YDL098C
location: complement(<284581..>285165)
location: region:284581-285165:-1
so has part: feature:284581-285165:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:284581-285165:-1:exon

YDL098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNU23
locus tag: YDL098C
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10449419|PMID:11720284]
note: Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome
codon start: 1
product: U4/U6-U5 snRNP complex subunit SNU23
translation: MSNFGRRTWDREEYAEQARSGYDDRSLKATLTPIELQALKSKYTNYDHLIKGSLKDLNKRKLTANTESLSSFKRGKKFGFYCDICNLTFKDTLQYIDHLNHKVHAIKFENLFDEPLIIDIRDNDDVPQEEFELCYHNLIKDFVEVRSMETQSKRKRLLDTDVEKAKKVATKPSIESESKVSQMMGFSNFATSKK
SIO_010081: YDL098C
subclass of: SO_0000673
so part of: YDL098C
location: complement(284581..285165)
location: region:284581-285165:-1
so has part: feature:284581-285165:-1:exon

NP_010185.1
type: Protein
SIO_000068: ncbiprotein

S000002256
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:284581-285165:-1:exon

YDL097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAS4
gene: RPN6
locus tag: YDL097C
gene synonym: NAS4
so part of: sequence
location: complement(<285391..>286695)
location: region:285391-286695:-1
so has part: feature:285391-286695:-1:exon
subclass of: SO_0000010

851461
type: Gene
SIO_000068: ncbigene

position:285391:-1
position: 285391
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:286695:-1
position: 286695
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:285391-286695:-1:exon

YDL097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAS4
gene: RPN6
locus tag: YDL097C
gene synonym: NAS4
product: proteasome regulatory particle lid subunit RPN6
transcript id: NM_001180156.1
SIO_010081: YDL097C
subclass of: SO_0000673
so part of: YDL097C
location: complement(<285391..>286695)
location: region:285391-286695:-1
so has part: feature:285391-286695:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:285391-286695:-1:exon

YDL097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAS4
gene: RPN6
locus tag: YDL097C
gene synonym: NAS4
experiment: EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12486135]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12486135]
experiment: EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12486135]
note: Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
codon start: 1
product: proteasome regulatory particle lid subunit RPN6
translation: MSLPGSKLEEARRLVNEKQYNEAEQVYLSLLDKDSSQSSAAAGASVDDKRRNEQETSILELGQLYVTMGAKDKLREFIPHSTEYMMQFAKSKTVKVLKTLIEKFEQVPDSLDDQIFVCEKSIEFAKREKRVFLKHSLSIKLATLHYQKKQYKDSLALINDLLREFKKLDDKPSLVDVHLLESKVYHKLRNLAKSKASLTAARTAANSIYCPTQTVAELDLMSGILHCEDKDYKTAFSYFFESFESYHNLTTHNSYEKACQVLKYMLLSKIMLNLIDDVKNILNAKYTKETYQSRGIDAMKAVAEAYNNRSLLDFNTALKQYEKELMGDELTRSHFNALYDTLLESNLCKIIEPFECVEISHISKIIGLDTQQVEGKLSQMILDKIFYGVLDQGNGWLYVYETPNQDATYDSALELVGQLNKVVDQLFEKASVLY
SIO_010081: YDL097C
subclass of: SO_0000673
so part of: YDL097C
location: complement(285391..286695)
location: region:285391-286695:-1
so has part: feature:285391-286695:-1:exon

NP_010186.1
type: Protein
SIO_000068: ncbiprotein

S000002255
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:285391-286695:-1:exon

YDL095W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMT1
locus tag: YDL095W
so part of: sequence
location: <287059..>289512
location: region:287059-289512:1
so has part: feature:287059-289512:1:exon
subclass of: SO_0000010

851462
type: Gene
SIO_000068: ncbigene

position:287059:1
position: 287059
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:289512:1
position: 289512
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287059-289512:1:exon

YDL095W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMT1
locus tag: YDL095W
product: dolichyl-phosphate-mannose-protein mannosyltransferase PMT1
transcript id: NM_001180154.1
SIO_010081: YDL095W
subclass of: SO_0000673
so part of: YDL095W
location: <287059..>289512
location: region:287059-289512:1
so has part: feature:287059-289512:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:287059-289512:1:exon

YDL095W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMT1
locus tag: YDL095W
EC number: 2.4.1.109
experiment: EXISTENCE:direct assay:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:21956107|PMID:8367478|PMID:8543034]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0035269 protein O-linked mannosylation [PMID:8367478|PMID:8543034]
experiment: EXISTENCE:direct assay:GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [PMID:12551906]
experiment: EXISTENCE:direct assay:GO:0097583 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex [PMID:12551906]
experiment: EXISTENCE:genetic interaction:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8543034]
experiment: EXISTENCE:genetic interaction:GO:0032527 protein exit from endoplasmic reticulum [PMID:21147851]
experiment: EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:8543034|PMID:21231968]
experiment: EXISTENCE:genetic interaction:GO:0071712 ER-associated misfolded protein catabolic process [PMID:18182384|PMID:21147851]
experiment: EXISTENCE:genetic interaction:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:21231968|PMID:23704572]
experiment: EXISTENCE:mutant phenotype:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8367478|PMID:8543034]
experiment: EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:8367478|PMID:18182384|PMID:8543034]
experiment: EXISTENCE:mutant phenotype:GO:0071712 ER-associated misfolded protein catabolic process [PMID:18182384]
experiment: EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:23704572]
experiment: EXISTENCE:physical interaction:GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [PMID:21956107|PMID:8543034]
note: Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; functions as a heterodimer with Pmt2p but can also pair with Pmt3p; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
codon start: 1
product: dolichyl-phosphate-mannose-protein mannosyltransferase PMT1
translation: MSEEKTYKRVEQDDPVPELDIKQGPVRPFIVTDPSAELASLRTMVTLKEKLLVACLAVFTAVIRLHGLAWPDSVVFDEVHFGGFASQYIRGTYFMDVHPPLAKMLYAGVASLGGFQGDFDFENIGDSFPSTTPYVLMRFFSASLGALTVILMYMTLRYSGVRMWVALMSAICFAVENSYVTISRYILLDAPLMFFIAAAVYSFKKYEMYPANSLNAYKSLLATGIALGMASSSKWVGLFTVTWVGLLCIWRLWFMIGDLTKSSKSIFKVAFAKLAFLLGVPFALYLVFFYIHFQSLTLDGDGASFFSPEFRSTLKNNKIPQNVVADVGIGSIISLRHLSTMGGYLHSHSHNYPAGSEQQQSTLYPHMDANNDWLLELYNAPGESLTTFQNLTDGTKVRLFHTVTRCRLHSHDHKPPVSESSDWQKEVSCYGYSGFDGDANDDWVVEIDKKNSAPGVAQERVIALDTKFRLRHAMTGCYLFSHEVKLPAWGFEQQEVTCASSGRHDLTLWYVENNSNPLLPEDTKRISYKPASFISKFIESHKKMWHINKNLVEPHVYESQPTSWPFLLRGISYWGENNRNVYLLGNAIVWWAVTAFIGIFGLIVITELFSWQLGKPILKDSKVVNFHVQVIHYLLGFAVHYAPSFLMQRQMFLHHYLPAYYFGILALGHALDIIVSYVFRSKRQMGYAVVITFLAASVYFFKSFSPIIYGTPWTQELCQKSQWLSGWDYNCNTYFSSLEEYKNQTLTKRESQPAATSTVEEITIEGDGPSYEDLMNEDGKKIFKDTEGNELDPEVVKKMLEEEGANILKVEKRAVLE
SIO_010081: YDL095W
subclass of: SO_0000673
so part of: YDL095W
location: 287059..289512
location: region:287059-289512:1
so has part: feature:287059-289512:1:exon

NP_010188.1
type: Protein
SIO_000068: ncbiprotein

S000002253
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:287059-289512:1:exon

YDL093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMT5
locus tag: YDL093W
so part of: sequence
location: <289909..>292140
location: region:289909-292140:1
so has part: feature:289909-292140:1:exon
subclass of: SO_0000010

851464
type: Gene
SIO_000068: ncbigene

position:289909:1
position: 289909
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292140:1
position: 292140
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:289909-292140:1:exon

YDL093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMT5
locus tag: YDL093W
product: putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5
transcript id: NM_001180152.1
SIO_010081: YDL093W
subclass of: SO_0000673
so part of: YDL093W
location: <289909..>292140
location: region:289909-292140:1
so has part: feature:289909-292140:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:289909-292140:1:exon

YDL093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMT5
locus tag: YDL093W
EC number: 2.4.1.109
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0097584 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex [PMID:12551906]
experiment: EXISTENCE:direct assay:GO:0097585 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex [PMID:12551906]
note: Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
codon start: 1
product: putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5
translation: MNKEHLLKVDPIPDVTIKRGPLRSFLITKPCDNLSSLRTVTSSKEKLLVGCLLIFTAIVRLHNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTANVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFFMACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMIGDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLKYNNVIKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYPAGSMQQQVTLYPHIDQNNKWIIELAEHPNENVTSFQNLTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCYGYEGFEGDINDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTCAYFAREDLTSWYIEENENEISLPNPEKVSYKKMSFWQKFVAIHKFMFYLNNYMDTSHAYSSEPKTWPLMLRGIDFWNENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILRDKHIINFHYQVFQYLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAFGHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIYATGWSSNLCKRSKWLGSWDFYCNSLLLSDSHYELNAES
SIO_010081: YDL093W
subclass of: SO_0000673
so part of: YDL093W
location: 289909..292140
location: region:289909-292140:1
so has part: feature:289909-292140:1:exon

NP_010190.1
type: Protein
SIO_000068: ncbiprotein

S000002251
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:289909-292140:1:exon

YDL092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRP14
locus tag: YDL092W
so part of: sequence
location: <292781..>293221
location: region:292781-293221:1
so has part: feature:292781-293221:1:exon
subclass of: SO_0000010

851466
type: Gene
SIO_000068: ncbigene

position:292781:1
position: 292781
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:293221:1
position: 293221
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292781-293221:1:exon

YDL092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRP14
locus tag: YDL092W
product: RNA-binding signal recognition particle subunit SRP14
transcript id: NM_001180151.1
SIO_010081: YDL092W
subclass of: SO_0000673
so part of: YDL092W
location: <292781..>293221
location: region:292781-293221:1
so has part: feature:292781-293221:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292781-293221:1:exon

YDL092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRP14
locus tag: YDL092W
experiment: EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]
experiment: EXISTENCE:direct assay:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:10921896]
experiment: EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:10573124]
note: Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
codon start: 1
product: RNA-binding signal recognition particle subunit SRP14
translation: MANTGCLSPGAFLSKVPEFFQTANEKHITVRLTAKRLIEHDPVEGNLEFDSTNHPDYDVSKKASEISVSSRSDREYPLLIRMSYGSHDKKTKCSTVVKASELDQFWQEYSSVFKGGMQNLIKKKKKKSKNGTISKTGKKNKVAKKN
SIO_010081: YDL092W
subclass of: SO_0000673
so part of: YDL092W
location: 292781..293221
location: region:292781-293221:1
so has part: feature:292781-293221:1:exon

NP_010191.1
type: Protein
SIO_000068: ncbiprotein

S000002250
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292781-293221:1:exon

YDL091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBX3
locus tag: YDL091C
so part of: sequence
location: complement(<293392..>294759)
location: region:293392-294759:-1
so has part: feature:293392-294759:-1:exon
subclass of: SO_0000010

851467
type: Gene
SIO_000068: ncbigene

position:293392:-1
position: 293392
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:294759:-1
position: 294759
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:293392-294759:-1:exon

YDL091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBX3
locus tag: YDL091C
product: Ubx3p
transcript id: NM_001180150.1
SIO_010081: YDL091C
subclass of: SO_0000673
so part of: YDL091C
location: complement(<293392..>294759)
location: region:293392-294759:-1
so has part: feature:293392-294759:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:293392-294759:-1:exon

YDL091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBX3
locus tag: YDL091C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:26362318]
experiment: EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:26362318]
experiment: EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]
experiment: EXISTENCE:mutant phenotype:GO:0033523 histone H2B ubiquitination [PMID:25183520]
experiment: EXISTENCE:mutant phenotype:GO:0072583 clathrin-dependent endocytosis [PMID:26362318]
note: Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; required for efficient clathrin-mediated endocytosis; ortholog of fission yeast Ucp10
codon start: 1
product: Ubx3p
translation: MDIFRHTFGNNDDSFIRIPGAFREEPPADLNGRTEDQNSNTNEPTQSRDGRLKSILHFLFQAPLIVLYYLLNFIVRSSRLLKPLLRLHGFYQRKHNRLLDHSSQLHRLLENLENEAQAVTCSEGNGNNDDGSNTDSTSNNESSGVQFSFGSLYNPENGTFSKSIMQNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKYQVLLWYGDVTTSEGLQVSNALKIRQYPLLGIISLKAEKKIELIARVEGSISNYKAQDLEAIFSKNYSRLIQLRQQRQNIEMQRLIRQQQDSRYQDSLRRDQQRESERLEQTQREQMEREHQRIENQWLLWRKSQLKPEPSSDKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDMLNSENDTLPVYQPANYQHQYSFKLITPVPRRELDLSTKISDVSGIYPSGNIVMERLDE
SIO_010081: YDL091C
subclass of: SO_0000673
so part of: YDL091C
location: complement(293392..294759)
location: region:293392-294759:-1
so has part: feature:293392-294759:-1:exon

NP_010192.1
type: Protein
SIO_000068: ncbiprotein

S000002249
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:293392-294759:-1:exon

YDL090C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DPR1
alternative label: FUS8
alternative label: SCG2
alternative label: SGP2
alternative label: STE16
gene: RAM1
locus tag: YDL090C
gene synonym: DPR1; FUS8; SCG2; SGP2; STE16
so part of: sequence
location: complement(<295034..>296329)
location: region:295034-296329:-1
so has part: feature:295034-296329:-1:exon
subclass of: SO_0000010

851468
type: Gene
SIO_000068: ncbigene

position:295034:-1
position: 295034
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:296329:-1
position: 296329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:295034-296329:-1:exon

YDL090C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DPR1
alternative label: FUS8
alternative label: SCG2
alternative label: SGP2
alternative label: STE16
gene: RAM1
locus tag: YDL090C
gene synonym: DPR1; FUS8; SCG2; SGP2; STE16
product: protein farnesyltransferase
transcript id: NM_001180149.1
SIO_010081: YDL090C
subclass of: SO_0000673
so part of: YDL090C
location: complement(<295034..>296329)
location: region:295034-296329:-1
so has part: feature:295034-296329:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:295034-296329:-1:exon

YDL090C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DPR1
alternative label: FUS8
alternative label: SCG2
alternative label: SGP2
alternative label: STE16
gene: RAM1
locus tag: YDL090C
gene synonym: DPR1; FUS8; SCG2; SGP2; STE16
EC number: 2.5.1.58
experiment: EXISTENCE:direct assay:GO:0004660 protein farnesyltransferase activity [PMID:9380709]
experiment: EXISTENCE:direct assay:GO:0005965 protein farnesyltransferase complex [PMID:8424764]
experiment: EXISTENCE:direct assay:GO:0018343 protein farnesylation [PMID:1763050]
note: Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
codon start: 1
product: protein farnesyltransferase
translation: MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS
SIO_010081: YDL090C
subclass of: SO_0000673
so part of: YDL090C
location: complement(295034..296329)
location: region:295034-296329:-1
so has part: feature:295034-296329:-1:exon

NP_010193.1
type: Protein
SIO_000068: ncbiprotein

S000002248
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:295034-296329:-1:exon

YDL089W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUR1
locus tag: YDL089W
so part of: sequence
location: <296820..>298274
location: region:296820-298274:1
so has part: feature:296820-298274:1:exon
subclass of: SO_0000010

851469
type: Gene
SIO_000068: ncbigene

position:296820:1
position: 296820
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:298274:1
position: 298274
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:296820-298274:1:exon

YDL089W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUR1
locus tag: YDL089W
product: Nur1p
transcript id: NM_001180148.1
SIO_010081: YDL089W
subclass of: SO_0000673
so part of: YDL089W
location: <296820..>298274
location: region:296820-298274:1
so has part: feature:296820-298274:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:296820-298274:1:exon

YDL089W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUR1
locus tag: YDL089W
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:25569132]
experiment: EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:18997772]
note: Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; involved in regulating mitotic exit; dephosphorylated by Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; interacts with Csm1p and Lrs4p; null mutant has elevated levels of unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery; Cdc28p substrate
codon start: 1
product: Nur1p
translation: MGSNDLINEAYDDSEVVGEERESKSAWMKRWYQLLTSPLDLQLVINEKLEMINWDAYAKSLAKPLGNFLTILFFIIRLLQDNLIKPNYYKLNVKSGAFDLSKSNKLKEFDYLWEISSSFQNNNQFYAFQSWYFVTLRFLNNLFRFTIFILLSLNLYVSCKFMFGYFKTYNLFHLKKEFNSPNLTKHNLKDLSKEYYEDIYKQSLWSMLKHFFRGSRDDGPHVNQNEDEIFFQLRKWIPTNFMINLFVSFSPTAIVFLSFSDVSFTSAIAIVFHQYILDYIITKRFQRSVDDDLILSSAALQEYEDKHIMARINQCSNIDTLSSAMGTRSKTPRIFTTHSLCGEEIREVYNYEKREFEALPKMTESVPGSRETRIKDYGGISQVSDHQSHPIGFHYSPRMSPYYRDKVLDNNLAQSSSNENLEKGGAYLPNQDQNRPSKSLSPLRKTPLSARQKRFEGSEFNVLNKNDINSILRSPKKKKNYHKR
SIO_010081: YDL089W
subclass of: SO_0000673
so part of: YDL089W
location: 296820..298274
location: region:296820-298274:1
so has part: feature:296820-298274:1:exon

NP_010194.1
type: Protein
SIO_000068: ncbiprotein

S000002247
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:296820-298274:1:exon

YDL088C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NUP59
gene: ASM4
locus tag: YDL088C
gene synonym: NUP59
so part of: sequence
location: complement(<298417..>300003)
location: region:298417-300003:-1
so has part: feature:298417-300003:-1:exon
subclass of: SO_0000010

851470
type: Gene
SIO_000068: ncbigene

position:298417:-1
position: 298417
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:300003:-1
position: 300003
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298417-300003:-1:exon

YDL088C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NUP59
gene: ASM4
locus tag: YDL088C
gene synonym: NUP59
product: FG-nucleoporin ASM4
transcript id: NM_001180147.1
SIO_010081: YDL088C
subclass of: SO_0000673
so part of: YDL088C
location: complement(<298417..>300003)
location: region:298417-300003:-1
so has part: feature:298417-300003:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:298417-300003:-1:exon

YDL088C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NUP59
gene: ASM4
locus tag: YDL088C
gene synonym: NUP59
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:17897934]
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:9864357]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]
experiment: EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]
experiment: EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]
note: FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
codon start: 1
product: FG-nucleoporin ASM4
translation: MFGIRSGNNNGGFTNLTSQAPQTTQMFQSQSQLQPQPQPQPQQQQQHLQFNGSSDASSLRFGNSLSNTVNANNYSSNIGNNSINNNNIKNGTNNISQHGQGNNPSWVNNPKKRFTPHTVIRRKTTKQNSSSDINQNDDSSSMNATMRNFSKQNQDSKHNERNKSAANNDINSLLSNFNDIPPSVTLQDWQREDEFGSIPSLTTQFVTDKYTAKKTNRSAYDSKNTPNVFDKDSYVRIANIEQNHLDNNYNTAETNNKVHETSSKSSSLSAIIVFGYPESISNELIEHFSHFGHIMEDFQVLRLGRGINPNTFRIFHNHDTGCDENDSTVNKSITLKGRNNESNNKKYPIFTGESWVKLTYNSPSSALRALQENGTIFRGSLIGCIPYSKNAVEQLAGCKIDNVDDIGEFNVSMYQNSSTSSTSNTPSPPNVIITDGTLLREDDNTPAGHAGNPTNISSPIVANSPNKRLDVIDGKLPFMQNAGPNSNIPNLLRNLESKMRQQEAKYRNNEPAGFTHKLSNWLFGWNDL
SIO_010081: YDL088C
subclass of: SO_0000673
so part of: YDL088C
location: complement(298417..300003)
location: region:298417-300003:-1
so has part: feature:298417-300003:-1:exon

NP_010195.1
type: Protein
SIO_000068: ncbiprotein

S000002246
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298417-300003:-1:exon

YDL087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EPE1
alternative label: EXM2
gene: LUC7
locus tag: YDL087C
gene synonym: EPE1; EXM2
so part of: sequence
location: complement(<300214..>300999)
location: region:300214-300999:-1
so has part: feature:300214-300999:-1:exon
subclass of: SO_0000010

851471
type: Gene
SIO_000068: ncbigene

position:300214:-1
position: 300214
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:300999:-1
position: 300999
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:300214-300999:-1:exon

YDL087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EPE1
alternative label: EXM2
gene: LUC7
locus tag: YDL087C
gene synonym: EPE1; EXM2
product: Luc7p
transcript id: NM_001180146.1
SIO_010081: YDL087C
subclass of: SO_0000673
so part of: YDL087C
location: complement(<300214..>300999)
location: region:300214-300999:-1
so has part: feature:300214-300999:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:300214-300999:-1:exon

YDL087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EPE1
alternative label: EXM2
gene: LUC7
locus tag: YDL087C
gene synonym: EPE1; EXM2
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:17726058]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:17726058]
experiment: EXISTENCE:mutant phenotype:GO:0005685 U1 snRNP [PMID:10500099]
experiment: EXISTENCE:mutant phenotype:GO:0006376 mRNA splice site selection [PMID:10500099]
note: Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Luc7p
translation: MSTMSTPAAEQRKLVEQLMGRDFSFRHNRYSHQKRDLGLHDPKICKSYLVGECPYDLFQGTKQSLGKCPQMHLTKHKIQYEREVKQGKTFPEFEREYLAILSRFVNECNGQISVALQNLKHTAEERMKIQQVTEELDVLDVRIGLMGQEIDSLIRADEVSMGMLQSVKLQELISKRKEVAKRVRNITENVGQSAQQKLQVCEVCGAYLSRLDTDRRLADHFLGKIHLGYVKMREDYDRLMKNNRTTNASKTATTLPGRRFV
SIO_010081: YDL087C
subclass of: SO_0000673
so part of: YDL087C
location: complement(300214..300999)
location: region:300214-300999:-1
so has part: feature:300214-300999:-1:exon

NP_010196.1
type: Protein
SIO_000068: ncbiprotein

S000002245
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:300214-300999:-1:exon

YDL086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL086W
so part of: sequence
location: <301413..>302234
location: region:301413-302234:1
so has part: feature:301413-302234:1:exon
subclass of: SO_0000010

851472
type: Gene
SIO_000068: ncbigene

position:301413:1
position: 301413
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:302234:1
position: 302234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:301413-302234:1:exon

YDL086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL086W
product: carboxymethylenebutenolidase
transcript id: NM_001180145.1
SIO_010081: YDL086W
subclass of: SO_0000673
so part of: YDL086W
location: <301413..>302234
location: region:301413-302234:1
so has part: feature:301413-302234:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:301413-302234:1:exon

YDL086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL086W
EC number: 3.1.1.45
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
codon start: 1
product: carboxymethylenebutenolidase
translation: MLITETFHDVQTSYGTTLRIYVYSPKIAGYPQAKFPGVILYSEIYQVTGPVRRFGQRIASEGYVVVAPAIYHNFMGPEALPYDVQGTDIGNEYKIKKPLESYDEDNKLCCDLLFQLPQFDGKRIGSTGMCLGGHLAFRALLDKRVTCATCFFPTDIHSRTLGLGQNDNSLERVSKELGNNQEMVLIFGTADTHVDPQGRDLIRKTLRDHGVKFTFLEILAAQHAFIRDEFSKGRFDSAITQSCLGFLFEQFNRKLRIDLGEFVDDNTPLEHVC
SIO_010081: YDL086W
subclass of: SO_0000673
so part of: YDL086W
location: 301413..302234
location: region:301413-302234:1
so has part: feature:301413-302234:1:exon

NP_010197.1
type: Protein
SIO_000068: ncbiprotein

S000002244
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:301413-302234:1:exon

YDL085C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL085C-A
so part of: sequence
location: complement(<302464..>302670)
location: region:302464-302670:-1
so has part: feature:302464-302670:-1:exon
subclass of: SO_0000010

851473
type: Gene
SIO_000068: ncbigene

position:302464:-1
position: 302464
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:302670:-1
position: 302670
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302464-302670:-1:exon

YDL085C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL085C-A
product: uncharacterized protein
transcript id: NM_001184455.1
SIO_010081: YDL085C-A
subclass of: SO_0000673
so part of: YDL085C-A
location: complement(<302464..>302670)
location: region:302464-302670:-1
so has part: feature:302464-302670:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:302464-302670:-1:exon

YDL085C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL085C-A
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Homolog of modifier of aggregation-4 (MOAG-4) from worm and small EDRK-rich factor protein (SERF1a) from human; highly conserved enhancer of amyloid formation of Abeta40 and alpha-synuclein both in vitro and in vivo; protein displays very high degree of disorder, segment spanning residues 36E-65K has strong helical propensity
codon start: 1
product: uncharacterized protein
translation: MARGNQRDLARQKNLKKQKDMAKNQKKSGDPKKRMESDAEILRQKQAAADARREAEKLEKLKAEKTRR
SIO_010081: YDL085C-A
subclass of: SO_0000673
so part of: YDL085C-A
location: complement(302464..302670)
location: region:302464-302670:-1
so has part: feature:302464-302670:-1:exon

NP_075208.1
type: Protein
SIO_000068: ncbiprotein

S000007588
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:302464-302670:-1:exon

YDL085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NDH2
gene: NDE2
locus tag: YDL085W
gene synonym: NDH2
so part of: sequence
location: <303211..>304848
location: region:303211-304848:1
so has part: feature:303211-304848:1:exon
subclass of: SO_0000010

851474
type: Gene
SIO_000068: ncbigene

position:303211:1
position: 303211
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:304848:1
position: 304848
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:303211-304848:1:exon

YDL085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NDH2
gene: NDE2
locus tag: YDL085W
gene synonym: NDH2
product: NADH-ubiquinone reductase (H(+)-translocating) NDE2
transcript id: NM_001180144.1
SIO_010081: YDL085W
subclass of: SO_0000673
so part of: YDL085W
location: <303211..>304848
location: region:303211-304848:1
so has part: feature:303211-304848:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:303211-304848:1:exon

YDL085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NDH2
gene: NDE2
locus tag: YDL085W
gene synonym: NDH2
EC number: 1.6.5.9
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006116 NADH oxidation [PMID:12032156]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9733747]
experiment: EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:9733747]
note: Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication
codon start: 1
product: NADH-ubiquinone reductase (H(+)-translocating) NDE2
translation: MLPRLGFARTARSIHRFKMTQISKPFFHSTEVGKPGPQQKLSKSYTAVFKKWFVRGLKLTFYTTLAGTLYVSYELYKESNPPKQVPQSTAFANGLKKKELVILGTGWGAISLLKKLDTSLYNVTVVSPRSFFLFTPLLPSTPVGTIEMKSIVEPVRSIARRTPGEVHYIEAEALDVDPKAKKVMVQSVSEDEYFVSSLSYDYLVVSVGAKTTTFNIPGVYGNANFLKEIEDAQNIRMKLMKTIEQASSFPVNDPERKRLLTFVVVGGGPTGVEFAAELQDYINQDLRKWMPDLSKEMKVILIEALPNILNMFDKTLIKYAEDLFARDEIDLQVNTAVKVVEPTYIRTLQNGQTNTDIEYGMLVWATGNEPIDFSKTLMSRIPEQTNRRGLLINDKLELLGSENSIYAIGDCTAHTGFFPTAQVAHQEGEYLAKILDKKLQIEQLEWDMLNSTDETEVSRLQKEVNLRKSKLDKFNYKHMGALAYIGSETAIADLHMGDSSYQLKGMFAFLFWKSAYLAMCLSIRNRILIAMDWTKVYFLGRDSSV
SIO_010081: YDL085W
subclass of: SO_0000673
so part of: YDL085W
location: 303211..304848
location: region:303211-304848:1
so has part: feature:303211-304848:1:exon

NP_010198.1
type: Protein
SIO_000068: ncbiprotein

S000002243
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:303211-304848:1:exon

YDL084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUB2
locus tag: YDL084W
so part of: sequence
location: <305237..>306577
location: region:305237-306577:1
so has part: feature:305237-306577:1:exon
subclass of: SO_0000010

851475
type: Gene
SIO_000068: ncbigene

position:305237:1
position: 305237
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:306577:1
position: 306577
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:305237-306577:1:exon

YDL084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SUB2
locus tag: YDL084W
product: ATP-dependent RNA helicase SUB2
transcript id: NM_001180143.1
SIO_010081: YDL084W
subclass of: SO_0000673
so part of: YDL084W
location: <305237..>306577
location: region:305237-306577:1
so has part: feature:305237-306577:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:305237-306577:1:exon

YDL084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SUB2
locus tag: YDL084W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000346 transcription export complex [PMID:11979277]
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:15942929]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:28059701]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006406 mRNA export from nucleus [PMID:11675790|PMID:11696331]
experiment: EXISTENCE:genetic interaction:GO:0003724 RNA helicase activity [PMID:11156602]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:11156602]
experiment: EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17960421]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11675790|PMID:11696331]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15942929]
experiment: EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:11675790]
note: Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: ATP-dependent RNA helicase SUB2
translation: MSHEGEEDLLEYSDNEQEIQIDASKAAEAGETGAATSATEGDNNNNTAAGDKKGSYVGIHSTGFKDFLLKPELSRAIIDCGFEHPSEVQQHTIPQSIHGTDVLCQAKSGLGKTAVFVLSTLQQLDPVPGEVAVVVICNARELAYQIRNEYLRFSKYMPDVKTAVFYGGTPISKDAELLKNKDTAPHIVVATPGRLKALVREKYIDLSHVKNFVIDECDKVLEELDMRRDVQEIFRATPRDKQVMMFSATLSQEIRPICRRFLQNPLEIFVDDEAKLTLHGLQQYYIKLEEREKNRKLAQLLDDLEFNQVIIFVKSTTRANELTKLLNASNFPAITVHGHMKQEERIARYKAFKDFEKRICVSTDVFGRGIDIERINLAINYDLTNEADQYLHRVGRAGRFGTKGLAISFVSSKEDEEVLAKIQERFDVKIAEFPEEGIDPSTYLNN
SIO_010081: YDL084W
subclass of: SO_0000673
so part of: YDL084W
location: 305237..306577
location: region:305237-306577:1
so has part: feature:305237-306577:1:exon

NP_010199.1
type: Protein
SIO_000068: ncbiprotein

S000002242
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:305237-306577:1:exon

YDL083C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS16B
locus tag: YDL083C
so part of: sequence
location: complement(<306926..>307789)
location: region:306926-307789:-1
so has part: feature:306926-307789:-1:exon
subclass of: SO_0000010

851476
type: Gene
SIO_000068: ncbigene

position:306926:-1
position: 306926
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:307789:-1
position: 307789
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:306926-307789:-1:exon

YDL083C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS16B
locus tag: YDL083C
product: ribosomal 40S subunit protein S16B
transcript id: NM_001180142.1
SIO_010081: YDL083C
subclass of: SO_0000673
so part of: YDL083C
location: complement(join(<306926..307333,307766..>307789))
location: region:306926-307789:-1
so has part: feature:307766-307789:-1:exon
so has part: feature:306926-307333:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307766-307789:-1:exon

position:307766:-1
position: 307766
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:306926-307333:-1:exon

position:307333:-1
position: 307333
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDL083C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS16B
locus tag: YDL083C
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
experiment: EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:30481328]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S16B
translation: MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR
SIO_010081: YDL083C
subclass of: SO_0000673
so part of: YDL083C
location: complement(join(306926..307333,307766..307789))
location: region:306926-307789:-1
so has part: feature:307766-307789:-1:exon
so has part: feature:306926-307333:-1:exon

NP_010200.1
type: Protein
SIO_000068: ncbiprotein

S000002241
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307766-307789:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:306926-307333:-1:exon

YDL082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL13A
locus tag: YDL082W
so part of: sequence
location: <308424..>309388
location: region:308424-309388:1
so has part: feature:308424-309388:1:exon
subclass of: SO_0000010

851477
type: Gene
SIO_000068: ncbigene

position:308424:1
position: 308424
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:309388:1
position: 309388
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:308424-309388:1:exon

YDL082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL13A
locus tag: YDL082W
product: ribosomal 60S subunit protein L13A
transcript id: NM_001180141.1
SIO_010081: YDL082W
subclass of: SO_0000673
so part of: YDL082W
location: join(<308424..308427,308793..>309388)
location: region:308424-309388:1
so has part: feature:308424-308427:1:exon
so has part: feature:308793-309388:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:308424-308427:1:exon

position:308427:1
position: 308427
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:308793-309388:1:exon

position:308793:1
position: 308793
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL13A
locus tag: YDL082W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L13A
translation: MAISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARATRAAKIAPRPLDLLRPVVRAPTVKYNRKVRAGRGFTLAEVKAAGLTAAYARTIGIAVDHRRQNRNQEIFDANVQRLKEYQSKIIVFPRNGKAPEAEQVLSAAATFPIAQPATDVEARAVQDNGESAFRTLRLARSEKKFRGIREKRAREKAEAEAEKKK
SIO_010081: YDL082W
subclass of: SO_0000673
so part of: YDL082W
location: join(308424..308427,308793..309388)
location: region:308424-309388:1
so has part: feature:308424-308427:1:exon
so has part: feature:308793-309388:1:exon

NP_010201.1
type: Protein
SIO_000068: ncbiprotein

S000002240
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:308424-308427:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:308793-309388:1:exon

YDL081C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPLA1
gene: RPP1A
locus tag: YDL081C
gene synonym: RPLA1
so part of: sequence
location: complement(<309802..>310122)
location: region:309802-310122:-1
so has part: feature:309802-310122:-1:exon
subclass of: SO_0000010

851478
type: Gene
SIO_000068: ncbigene

position:309802:-1
position: 309802
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:310122:-1
position: 310122
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:309802-310122:-1:exon

YDL081C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPLA1
gene: RPP1A
locus tag: YDL081C
gene synonym: RPLA1
product: ribosomal protein P1A
transcript id: NM_001180140.1
SIO_010081: YDL081C
subclass of: SO_0000673
so part of: YDL081C
location: complement(<309802..>310122)
location: region:309802-310122:-1
so has part: feature:309802-310122:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:309802-310122:-1:exon

YDL081C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPLA1
gene: RPP1A
locus tag: YDL081C
gene synonym: RPLA1
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:24391917]
experiment: EXISTENCE:direct assay:GO:0045860 positive regulation of protein kinase activity [PMID:24391917]
experiment: EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1601875]
note: Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
codon start: 1
product: ribosomal protein P1A
translation: MSTESALSYAALILADSEIEISSEKLLTLTNAANVPVENIWADIFAKALDGQNLKDLLVNFSAGAAAPAGVAGGVAGGEAGEAEAEKEEEEAKEESDDDMGFGLFD
SIO_010081: YDL081C
subclass of: SO_0000673
so part of: YDL081C
location: complement(309802..310122)
location: region:309802-310122:-1
so has part: feature:309802-310122:-1:exon

NP_010202.1
type: Protein
SIO_000068: ncbiprotein

S000002239
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:309802-310122:-1:exon

YDL080C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KID1
gene: THI3
locus tag: YDL080C
gene synonym: KID1
so part of: sequence
location: complement(<310642..>312471)
location: region:310642-312471:-1
so has part: feature:310642-312471:-1:exon
subclass of: SO_0000010

851479
type: Gene
SIO_000068: ncbigene

position:310642:-1
position: 310642
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:312471:-1
position: 312471
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:310642-312471:-1:exon

YDL080C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KID1
gene: THI3
locus tag: YDL080C
gene synonym: KID1
product: branched-chain-2-oxoacid decarboxylase THI3
transcript id: NM_001180139.1
SIO_010081: YDL080C
subclass of: SO_0000673
so part of: YDL080C
location: complement(<310642..>312471)
location: region:310642-312471:-1
so has part: feature:310642-312471:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:310642-312471:-1:exon

YDL080C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KID1
gene: THI3
locus tag: YDL080C
gene synonym: KID1
EC number: 4.1.1.72
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16194233|PMID:16850348|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16194233]
experiment: EXISTENCE:mutant phenotype:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:16194233|PMID:19013460]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:19013460]
experiment: EXISTENCE:physical interaction:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:16194233|PMID:19013460]
note: Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected
codon start: 1
product: branched-chain-2-oxoacid decarboxylase THI3
translation: MNSSYTQRYALPKCIAISDYLFHRLNQLNIHTIFGLSGEFSMPLLDKLYNIPNLRWAGNSNELNAAYAADGYSRLKGLGCLITTFGVGELSAINGVAGSYAEHVGILHIVGMPPTSAQTKQLLLHHTLGNGDFTVFHRIASDVACYTTLIIDSELCADEVDKCIKKAWIEQRPVYMGMPVNQVNLPIESARLNTPLDLQLHKNDPDVEKEVISRILSFIYKSQNPAIIVDACTSRQNLIEETKELCNRLKFPVFVTPMGKGTVNETDPQFGGVFTGSISAPEVREVVDFADFIIVIGCMLSEFSTSTFHFQYKTKNCALLYSTSVKLKNATYPDLSIKLLLQKILANLDESKLSYQPSEQPSMMVPRPYPAGNVLLRQEWVWNEISHWFQPGDIIITETGASAFGVNQTRFPVNTLGISQALWGSVGYTMGACLGAEFAVQEINKDKFPATKHRVILFMGDGAFQLTVQELSTIVKWGLTPYIFVMNNQGYSVDRFLHHRSDASYYDIQPWNYLGLLRVFGCTNYETKKIITVGEFRSMISDPNFATNDKIRMIEIMLPPRDVPQALLDRWVVEKEQSKQVQEENENSSAVNTPTPEFQPLLKKNQVGY
SIO_010081: YDL080C
subclass of: SO_0000673
so part of: YDL080C
location: complement(310642..312471)
location: region:310642-312471:-1
so has part: feature:310642-312471:-1:exon

NP_010203.1
type: Protein
SIO_000068: ncbiprotein

S000002238
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:310642-312471:-1:exon

YDL079C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRK1
locus tag: YDL079C
so part of: sequence
location: complement(<312951..>314748)
location: region:312951-314748:-1
so has part: feature:312951-314748:-1:exon
subclass of: SO_0000010

851480
type: Gene
SIO_000068: ncbigene

position:312951:-1
position: 312951
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:314748:-1
position: 314748
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:312951-314748:-1:exon

YDL079C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRK1
locus tag: YDL079C
product: putative serine/threonine protein kinase MRK1
transcript id: NM_001180138.1
SIO_010081: YDL079C
subclass of: SO_0000673
so part of: YDL079C
location: complement(join(<312951..314044,314337..>314748))
location: region:312951-314748:-1
so has part: feature:314337-314748:-1:exon
so has part: feature:312951-314044:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:314337-314748:-1:exon

position:314337:-1
position: 314337
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:312951-314044:-1:exon

position:314044:-1
position: 314044
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDL079C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRK1
locus tag: YDL079C
EC number: 2.7.11.1
experiment: EXISTENCE:genetic interaction:GO:0042176 regulation of protein catabolic process [PMID:10958669]
note: Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication
codon start: 1
product: putative serine/threonine protein kinase MRK1
translation: MTDVLRSLVRKISFNNSDNLQLKHKTSIQSNTALEKKKRKPDTIKKVSDVQVHHTVPNFNNSSEYINDIENLIISKLIDGGKEGIAVDHIEHANISDSKTDGKVANKHENISSKLSKEKVEKMINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNHGGTIDISYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKRCDTDTYVKAQNLRIFDFDVETELGHVPLVERPAIEERLKHFVSAPSSSL
SIO_010081: YDL079C
subclass of: SO_0000673
so part of: YDL079C
location: complement(join(312951..314044,314337..314748))
location: region:312951-314748:-1
so has part: feature:314337-314748:-1:exon
so has part: feature:312951-314044:-1:exon

NP_010204.1
type: Protein
SIO_000068: ncbiprotein

S000002237
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:314337-314748:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:312951-314044:-1:exon

YDL078C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDH3
locus tag: YDL078C
so part of: sequence
location: complement(<315357..>316388)
location: region:315357-316388:-1
so has part: feature:315357-316388:-1:exon
subclass of: SO_0000010

851481
type: Gene
SIO_000068: ncbigene

position:315357:-1
position: 315357
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:316388:-1
position: 316388
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:315357-316388:-1:exon

YDL078C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDH3
locus tag: YDL078C
product: malate dehydrogenase MDH3
transcript id: NM_001180137.1
SIO_010081: YDL078C
subclass of: SO_0000673
so part of: YDL078C
location: complement(<315357..>316388)
location: region:315357-316388:-1
so has part: feature:315357-316388:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:315357-316388:-1:exon

YDL078C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDH3
locus tag: YDL078C
EC number: 1.1.1.37
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:1447211|PMID:7628449|PMID:22375831]
experiment: EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:8824293]
experiment: EXISTENCE:direct assay:GO:0030060 L-malate dehydrogenase activity [PMID:1447211]
experiment: EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:7628449]
experiment: EXISTENCE:mutant phenotype:GO:0006735 NADH regeneration [PMID:7628449]
experiment: EXISTENCE:mutant phenotype:GO:0030060 L-malate dehydrogenase activity [PMID:1986231|PMID:7628449]
note: Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; mutation in human homolog MDH2 causes early-onset severe encephalopathy
codon start: 1
product: malate dehydrogenase MDH3
translation: MVKVAILGASGGVGQPLSLLLKLSPYVSELALYDIRAAEGIGKDLSHINTNSSCVGYDKDSIENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVISNPVNSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTTMHRKVTVIGGHSGETIIPIITDKSLVFQLDKQYEHFIHRVQFGGDEIVKAKQGAGSATLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPGLKNGKKAQQLVGDNSIEYFSLPIVLRNGSVVSIDTSVLEKLSPREEQLVNTAVKELRKNIEKGKSFILDSSKL
SIO_010081: YDL078C
subclass of: SO_0000673
so part of: YDL078C
location: complement(315357..316388)
location: region:315357-316388:-1
so has part: feature:315357-316388:-1:exon

NP_010205.1
type: Protein
SIO_000068: ncbiprotein

S000002236
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:315357-316388:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS412; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 316771..317230
location: region:316771-317230:1
so has part: feature:316771-317230:1:region

S000130172
type: SGD
SIO_000068: sgd

position:316771:1
position: 316771
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:317230:1
position: 317230
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316771-317230:1:region

YDL077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CVT4
alternative label: VPL18
alternative label: VPL22
alternative label: VPS39
gene: VAM6
locus tag: YDL077C
gene synonym: CVT4; VPL18; VPL22; VPS39
so part of: sequence
location: complement(<316971..>320120)
location: region:316971-320120:-1
so has part: feature:316971-320120:-1:exon
subclass of: SO_0000010

851482
type: Gene
SIO_000068: ncbigene

position:316971:-1
position: 316971
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:320120:-1
position: 320120
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316971-320120:-1:exon

YDL077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CVT4
alternative label: VPL18
alternative label: VPL22
alternative label: VPS39
gene: VAM6
locus tag: YDL077C
gene synonym: CVT4; VPL18; VPL22; VPS39
product: Vam6p
transcript id: NM_001180136.1
SIO_010081: YDL077C
subclass of: SO_0000673
so part of: YDL077C
location: complement(<316971..>320120)
location: region:316971-320120:-1
so has part: feature:316971-320120:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316971-320120:-1:exon

YDL077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CVT4
alternative label: VPL18
alternative label: VPL22
alternative label: VPS39
gene: VAM6
locus tag: YDL077C
gene synonym: CVT4; VPL18; VPL22; VPS39
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19748353|PMID:9111041|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:19748353]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]
experiment: EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]
experiment: EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026035|PMID:25026036]
experiment: EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]
experiment: EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9111041]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12730205]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]
experiment: EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]
experiment: EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11062257|PMID:18809726|PMID:20604902|PMID:21325627]
note: Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles
codon start: 1
product: Vam6p
translation: MLRAQKLHSLKSSDITAILPTEQSQKLVLAKKNGDVEVYSRDGNTLKLFQVYPDLLQNAKNDPLPPVIENFYFANELSTIFAQCKETLILLSTTNLHEYDRIIDRRGINHCWLFERSHKNKEEKNTYLIYSTINTAKMRVLIWEGRTYKNMMEASLSYRKETIRSIYPGETGITLATDLGIYHWPYNKPSLIRIEKTVKNKFPKDMISALTELKEQAEKVIEKKPKKNSHFDAQSFSSMDRMSRKSSMSSLWYRTIRNERGNKIRYTFELDGNDATPMIIDGATKKIFKVELMHNNEEPFLIATDHATFSESNSEFDHMQYLSSNLLMLYNSSTIKFVDYENGFTFLQQKIPEGIKWVKNLSGTYFLVWTSNDEVQLFSYHVDDGSEDDDQESICGDINDPDFYQLWRKVLFYKFFIDSPHSKELCVSDNPEESLDICAMKLRDLTVMWCLRIFDKFQNYMVQLERSRNSRMIRSKCEEMIIKSIFDLFIKFWAPPQLVILKVFPSAISSLVLEITGQEHHCLLKEAEEVKETYDIPPHLLNRWCLPYLTDTRRHLQNLLSKENDDESRITWCYRDREIKQSFDFFLISNHDDVDLNTMLTLIDTVLFKCYLYYNPPMVGPFIRVENHCDSHVIVTELKIRHMFKDLIDFYYKRGNHEEALKFLTDLVDELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLLNRHNDSIKEILSSIFFYDSQACSSRDHLKVYGYIKKFDKLLAIQYLEFAISTFRLEGNKLHTVLIKLYLENLDIPSTRIKLKSLLETTSVYEPRTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSKLENHKEAVHILLDEIDDYKAATSYCNDVYQSDSTKGEELLLYLYSKLVSIYDSNRNSKLILNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVELVATTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNCGKVLQERFNAKNEKSSRIKQKTLGEVINELNNK
SIO_010081: YDL077C
subclass of: SO_0000673
so part of: YDL077C
location: complement(316971..320120)
location: region:316971-320120:-1
so has part: feature:316971-320120:-1:exon

NP_010206.1
type: Protein
SIO_000068: ncbiprotein

S000002235
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316971-320120:-1:exon

YDL076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RXT3
locus tag: YDL076C
so part of: sequence
location: complement(<320668..>321552)
location: region:320668-321552:-1
so has part: feature:320668-321552:-1:exon
subclass of: SO_0000010

851483
type: Gene
SIO_000068: ncbigene

position:320668:-1
position: 320668
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:321552:-1
position: 321552
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:320668-321552:-1:exon

YDL076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RXT3
locus tag: YDL076C
product: Rxt3p
transcript id: NM_001180135.1
SIO_010081: YDL076C
subclass of: SO_0000673
so part of: YDL076C
location: complement(<320668..>321552)
location: region:320668-321552:-1
so has part: feature:320668-321552:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:320668-321552:-1:exon

YDL076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RXT3
locus tag: YDL076C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16314178|PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]
note: Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress
codon start: 1
product: Rxt3p
translation: MSVSEQDPNRAYRETQSQIYKLQETLLNSARTKNKQEEGQESNTHSFPEQYMHYQNGRNSAYDLPNVSSQSVLAFTEKHYPNKLKNLGTLYYNRFKEGSFDEDSTSYSDRHSFPYNLYDNTLPPPFLPAIGIQNINNIATLKITYEDIQASFNNIESPRKRNNEIWGCDIYSDDSDPILVLRHCGFKIGAPSGGSFHKLRRTPVNVTNQDNVTGNLPLLEGTPFDLEVELLFLPTLQKYPSVKRFDITSREWGSEATVIHDGLSYGIYSIVIKQRLDRDKPHEPNGYIKNLKWT
SIO_010081: YDL076C
subclass of: SO_0000673
so part of: YDL076C
location: complement(320668..321552)
location: region:320668-321552:-1
so has part: feature:320668-321552:-1:exon

NP_010207.1
type: Protein
SIO_000068: ncbiprotein

S000002234
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:320668-321552:-1:exon

YDL075W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL34
gene: RPL31A
locus tag: YDL075W
gene synonym: RPL34
so part of: sequence
location: <322226..>322988
location: region:322226-322988:1
so has part: feature:322226-322988:1:exon
subclass of: SO_0000010

851484
type: Gene
SIO_000068: ncbigene

position:322226:1
position: 322226
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:322988:1
position: 322988
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:322226-322988:1:exon

YDL075W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL34
gene: RPL31A
locus tag: YDL075W
gene synonym: RPL34
product: ribosomal 60S subunit protein L31A
transcript id: NM_001180134.1
SIO_010081: YDL075W
subclass of: SO_0000673
so part of: YDL075W
location: join(<322226..322282,322704..>322988)
location: region:322226-322988:1
so has part: feature:322226-322282:1:exon
so has part: feature:322704-322988:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:322226-322282:1:exon

position:322282:1
position: 322282
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:322704-322988:1:exon

position:322704:1
position: 322704
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL075W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL34
gene: RPL31A
locus tag: YDL075W
gene synonym: RPL34
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:18829863]
note: Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L31A
translation: MAGLKDVVTREYTINLHKRLHGVSFKKRAPRAVKEIKKFAKLHMGTDDVRLAPELNQAIWKRGVKGVEYRLRLRISRKRNEEEDAKNPLFSYVEPVLVASAKGLQTVVVEEDA
SIO_010081: YDL075W
subclass of: SO_0000673
so part of: YDL075W
location: join(322226..322282,322704..322988)
location: region:322226-322988:1
so has part: feature:322226-322282:1:exon
so has part: feature:322704-322988:1:exon

NP_010208.1
type: Protein
SIO_000068: ncbiprotein

S000002233
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:322226-322282:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:322704-322988:1:exon

YNCD0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR63
locus tag: YNCD0002C
so part of: sequence
location: complement(323217..323471)
location: region:323217-323471:-1
so has part: feature:323217-323471:-1:exon
subclass of: SO_0000578

9164876
type: Gene
SIO_000068: ncbigene

position:323217:-1
position: 323217
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:323471:-1
position: 323471
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323217-323471:-1:exon

YNCD0002C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR63
locus tag: YNCD0002C
product: SNR63
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
experiment: EXISTENCE:physical interaction:GO:0031428 box C/D RNP complex [PMID:11081632]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position A2256
transcript id: NR_132159.1
SIO_010081: YNCD0002C
subclass of: SO_0000673
so part of: YNCD0002C
location: complement(323217..323471)
location: region:323217-323471:-1
so has part: feature:323217-323471:-1:exon

S000006454
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323217-323471:-1:exon

YDL074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BRE1
locus tag: YDL074C
so part of: sequence
location: complement(<324047..>326149)
location: region:324047-326149:-1
so has part: feature:324047-326149:-1:exon
subclass of: SO_0000010

851485
type: Gene
SIO_000068: ncbigene

position:324047:-1
position: 324047
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326149:-1
position: 326149
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:324047-326149:-1:exon

YDL074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BRE1
locus tag: YDL074C
product: E3 ubiquitin-protein ligase BRE1
transcript id: NM_001180133.1
SIO_010081: YDL074C
subclass of: SO_0000673
so part of: YDL074C
location: complement(<324047..>326149)
location: region:324047-326149:-1
so has part: feature:324047-326149:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:324047-326149:-1:exon

YDL074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BRE1
locus tag: YDL074C
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12876294]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:23103252]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:19531475]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:16783014]
experiment: EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:15632065]
experiment: EXISTENCE:mutant phenotype:GO:0010390 histone monoubiquitination [PMID:12535538|PMID:12535539]
experiment: EXISTENCE:mutant phenotype:GO:0016574 histone ubiquitination [PMID:23103252]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:23103252]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:12535539]
experiment: EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:16166626|PMID:16783014]
experiment: EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:15632126]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:15280549]
experiment: EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:19531475]
experiment: EXISTENCE:mutant phenotype:GO:0070534 protein K63-linked ubiquitination [PMID:25622294]
experiment: EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:19531475]
note: E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing
codon start: 1
product: E3 ubiquitin-protein ligase BRE1
translation: MTAEPATKKIKLELSDPSEPLTQSDVIAFQKEALFRCINRRRVDFEALRKQYELSRRECIDVSRKLANIMALIVTLARFIETFCTDANEKQLCREIAQGDETLIVQRSDSFMKLLTKYGKPNTTDSNTNSNASDHIQELTTELKNLRKSKEELFYENSQLTEEISALKEYYTNIIRKYDRDESFTIKRVFKEDKTDAVKELREDEKESNENNIKSGNKDSSAINGDNTSKKSEKGDELVQAEDERKEDAENEKLELDLKFSDLRAEINSLSSTIKDLENIRRENEEELIKTRSEVSNLKKQQIAAADQDPDFKSYDHESLLAKIQHLTEQNAELSEINSSFLSKFQVLAKEKEIYTKKVREEFQKSLDSLVEMNSSLEKDVVRIRTARDDLLSKIAILEAEKSKTEVLSDLQHAIDILKEQWTKIDQRSNDTKSSSTQDALIKEIQDLEKGFRELSDLTHKKYSEIINHESVISKLTVEKTKADQKYFAAMRSKDSILIEIKTLSKSLSKSNELILQLKDSDRLLQQKIGNLHKQLDLSQNNERRLIDSSKTETLKIIDLNNTSTKLKRSLEKLQEESNKSIADMTHLETKLNDTEIELKHFKQKASHLESKCEKLHDTLFRGNNKNKGSSDEALVEELANFRTLVYCSLCSKNWKNMAIKTCGHVFCENCCKERLAARMRKCPTCNKAFSSNDLLTVHL
SIO_010081: YDL074C
subclass of: SO_0000673
so part of: YDL074C
location: complement(324047..326149)
location: region:324047-326149:-1
so has part: feature:324047-326149:-1:exon

NP_010209.1
type: Protein
SIO_000068: ncbiprotein

S000002232
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:324047-326149:-1:exon

YDL073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AHK1
locus tag: YDL073W
so part of: sequence
location: <326613..>329567
location: region:326613-329567:1
so has part: feature:326613-329567:1:exon
subclass of: SO_0000010

851486
type: Gene
SIO_000068: ncbigene

position:326613:1
position: 326613
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:329567:1
position: 329567
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326613-329567:1:exon

YDL073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AHK1
locus tag: YDL073W
product: Ahk1p
transcript id: NM_001180132.1
SIO_010081: YDL073W
subclass of: SO_0000673
so part of: YDL073W
location: <326613..>329567
location: region:326613-329567:1
so has part: feature:326613-329567:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:326613-329567:1:exon

YDL073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AHK1
locus tag: YDL073W
experiment: EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:26787842]
experiment: EXISTENCE:genetic interaction:GO:0043407 negative regulation of MAP kinase activity [PMID:26787842]
experiment: EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:26787842]
experiment: EXISTENCE:physical interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:26787842]
note: Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene
codon start: 1
product: Ahk1p
translation: MGPAIHNQLYECGLKTTSQDGFLMDNYETQLFQSLNRFINFINNANQSASNKEQNTKFCKSSSNFLRLKLLTVLRQWCDSSRSNCTLEVRDVLTQWWVTLLNFLNSDTSLQIDTALELSLSIELTSVCLECLSKIMTILIILPFHSSRDMEIYSHHLLLTIHCITNKLILISKNSKKLKRTNSDDKCSINDKKLQYLNKYSSLLRAFIGKLNAYAFFYLPEDFHFDTILLLTVSPQISSSIQTSLFSWKKRQYKFTDDQGQMIRTEAFENKDTKFFKIIVSYIKNDFVLMSFYWHYWYIILQFMKFSDSDVGIKKSTLSCIPGSEILLTHVTTRFLNSDLNKFTRIIKQTPNPRIANENVTESHPNFKSLNSSNALITSERINDYVFSNFKTIKLWECLRSLSGCILKENHPEYLENMLSLHESLLIDYVSTISAYDYIAANVIYNKVLQFIIFQFESLPSLKFIQWRSWYNGLLSMLRTKNVNCQTVSLLCLFNIWKHVTIEDRDEIVKVLLSDFWESLIFENEFPLIRILFMKVLVFKIIPSVQNSSSLRFLPHDRIKQLYEELLVNKEELFEMQKHDSNDIVAHRKNALVFNGNSRLMMIPKKPNTEDHLVYKINHDKNLTTERFPSVSSVANTRPNVILKNGKYAYDILDEMTSKAAFLLAEKKTRLNPKKNHKIMDGYEGGQENEDNDEDSEDSGSHKNKRKEGNSSLSATLNTWLSKFSSTSEDSQKKKEQANELGNDFEYDEDVADFAEILPKQSSSNIEKIFKHGNNSGSMVSYNSSIKLNRRENILIGPPELRFSNEIKEHNSIATIFKLVFIQTNRRVVEKIDLANMKWGTIHGGSKYMKPLPVPKDLVASVAKNESETRNLATLCGNGLDFEIPVPDFNIFGKCMEDEQDVAKIGNQNVEDLKVTGGREVTIWKQIQDMKLRTRIQKICVLIETFNATVREYFEFSNRLEHDGIFIDFEVRKPSSNNSINIKV
SIO_010081: YDL073W
subclass of: SO_0000673
so part of: YDL073W
location: 326613..329567
location: region:326613-329567:1
so has part: feature:326613-329567:1:exon

NP_010210.1
type: Protein
SIO_000068: ncbiprotein

S000002231
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:326613-329567:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS413; Autonomously Replicating Sequence
so part of: sequence
location: 329566..329814
location: region:329566-329814:1
so has part: feature:329566-329814:1:region

S000118432
type: SGD
SIO_000068: sgd

position:329566:1
position: 329566
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:329814:1
position: 329814
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:329566-329814:1:region

YDL072C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YET3
locus tag: YDL072C
so part of: sequence
location: complement(<329836..>330447)
location: region:329836-330447:-1
so has part: feature:329836-330447:-1:exon
subclass of: SO_0000010

851487
type: Gene
SIO_000068: ncbigene

position:329836:-1
position: 329836
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330447:-1
position: 330447
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:329836-330447:-1:exon

YDL072C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YET3
locus tag: YDL072C
product: Yet3p
transcript id: NM_001180131.1
SIO_010081: YDL072C
subclass of: SO_0000673
so part of: YDL072C
location: complement(<329836..>330447)
location: region:329836-330447:-1
so has part: feature:329836-330447:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:329836-330447:-1:exon

YDL072C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YET3
locus tag: YDL072C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20378542|PMID:11914276|PMID:26928762]
note: hypothetical protein; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
codon start: 1
product: Yet3p
translation: MSLYYTLVFAILVVEIFMFSILALPIPSRYRRPLTLLLLKPFKSSTVQVAIKCVLGFILLLFIDCINRVYSIDKELQLSSASQNNGAIIAQDRIEVLSRKFFAQRNMYLTGITLFLTFVVVRTFGLVIELLTMKDIYRASPPVASSDVKKNDSVTAEAAAQSGASKDDHGDEKNFELLKKIQDIDDEIARLKEKSESLQEEIN
SIO_010081: YDL072C
subclass of: SO_0000673
so part of: YDL072C
location: complement(329836..330447)
location: region:329836-330447:-1
so has part: feature:329836-330447:-1:exon

NP_010211.1
type: Protein
SIO_000068: ncbiprotein

S000002230
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:329836-330447:-1:exon

YDL070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BDF2
locus tag: YDL070W
so part of: sequence
location: <331024..>332940
location: region:331024-332940:1
so has part: feature:331024-332940:1:exon
subclass of: SO_0000010

851488
type: Gene
SIO_000068: ncbigene

position:331024:1
position: 331024
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332940:1
position: 332940
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:331024-332940:1:exon

YDL070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BDF2
locus tag: YDL070W
product: Bdf2p
transcript id: NM_001180129.1
SIO_010081: YDL070W
subclass of: SO_0000673
so part of: YDL070W
location: <331024..>332940
location: region:331024-332940:1
so has part: feature:331024-332940:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:331024-332940:1:exon

YDL070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BDF2
locus tag: YDL070W
experiment: EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:17526728]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:12620224]
experiment: EXISTENCE:direct assay:GO:0070577 lysine-acetylated histone binding [PMID:20126658]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0031452 negative regulation of heterochromatin formation [PMID:16239142]
experiment: EXISTENCE:mutant phenotype:GO:0031452 negative regulation of heterochromatin formation [PMID:16239142]
experiment: EXISTENCE:physical interaction:GO:0001094 TFIID-class transcription factor complex binding [PMID:10783167]
note: Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication
codon start: 1
product: Bdf2p
translation: MSRTNMDTRHAHSALLAAPQSATANSRSSNSSSESSSNKNNINVGVGDDSGNVSAVSIDDGPHFRDIFHYGHEENYKLASSGITNLNSSSHAHQTLSPISISNASTPESFPEHPLGLERETEPALEAEMEAEELPPHQSKYLLSSIKATKRLKDARPFLKPVDPIALNIPHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQKYFEKKLSAMPPRVLPASALKKTSRNRKKNEDMDSPLVIRRSVSTTNDNIGESGNREGVSGGRPKRTIHPPKSKDLFDIYENSKPKSKTLQKKFRTCLKILKVLMSKKNSDINFPFLQPVDPIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEVHSMGKKLKELFNFHWLENQDILNEIETDSDLEEDNYSSSYSSDDEYDDEDINENDITNPAIQYLEQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLKKSITDKINELSDLEMNGMIRIIKNSLPADEILTSNEDEIEIDLDILDEATIARIYERYFEKKNNNNSKRKLSGNYSTAPTNKKKKTLKFLEKDEIINNNNYSDSEEDSSDSSDSDSD
SIO_010081: YDL070W
subclass of: SO_0000673
so part of: YDL070W
location: 331024..332940
location: region:331024-332940:1
so has part: feature:331024-332940:1:exon

NP_010213.1
type: Protein
SIO_000068: ncbiprotein

S000002228
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:331024-332940:1:exon

YDL069C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CBS1
locus tag: YDL069C
so part of: sequence
location: complement(<333121..>333810)
location: region:333121-333810:-1
so has part: feature:333121-333810:-1:exon
subclass of: SO_0000010

851491
type: Gene
SIO_000068: ncbigene

position:333121:-1
position: 333121
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:333810:-1
position: 333810
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:333121-333810:-1:exon

YDL069C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CBS1
locus tag: YDL069C
product: Cbs1p
transcript id: NM_001180128.1
SIO_010081: YDL069C
subclass of: SO_0000673
so part of: YDL069C
location: complement(<333121..>333810)
location: region:333121-333810:-1
so has part: feature:333121-333810:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:333121-333810:-1:exon

YDL069C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CBS1
locus tag: YDL069C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:1745228]
experiment: EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:3033440]
experiment: EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:3033440]
experiment: EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:3033440]
experiment: EXISTENCE:physical interaction:GO:0005761 mitochondrial ribosome [PMID:15927884]
note: Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
codon start: 1
product: Cbs1p
translation: MLRTKVFATTVARISGIRRYIPIRTINTVTKKNISKIEKLCEVLEVNPDGYKGKERIPTKELTKLLYTTSRNMLVRVPMTGDLSTGNTFETRNETLQKLGEQLIHLEINKMLTITFTNFNQFNIMNKNFNYIHNLDRARVVNMDSISWLIKNSLKINQLAHLRIPANLPKEMGLTSSSNDFQNLNDWKVILSFIGYLKLLEIKNDNKKFIESIIKTICIPLINYHLRKS
SIO_010081: YDL069C
subclass of: SO_0000673
so part of: YDL069C
location: complement(333121..333810)
location: region:333121-333810:-1
so has part: feature:333121-333810:-1:exon

NP_010214.2
type: Protein
SIO_000068: ncbiprotein

S000002227
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:333121-333810:-1:exon

YDL067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX9
locus tag: YDL067C
so part of: sequence
location: complement(<334217..>334396)
location: region:334217-334396:-1
so has part: feature:334217-334396:-1:exon
subclass of: SO_0000010

851492
type: Gene
SIO_000068: ncbigene

position:334217:-1
position: 334217
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334396:-1
position: 334396
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:334217-334396:-1:exon

YDL067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX9
locus tag: YDL067C
product: cytochrome c oxidase subunit VIIa
transcript id: NM_001180126.1
SIO_010081: YDL067C
subclass of: SO_0000673
so part of: YDL067C
location: complement(<334217..>334396)
location: region:334217-334396:-1
so has part: feature:334217-334396:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:334217-334396:-1:exon

YDL067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX9
locus tag: YDL067C
experiment: EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]
note: Subunit VIIa of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain
codon start: 1
product: cytochrome c oxidase subunit VIIa
translation: MTIAPITGTIKRRVIMDIVLGFSLGGVMASYWWWGFHMDKINKREKFYAELAERKKQEN
SIO_010081: YDL067C
subclass of: SO_0000673
so part of: YDL067C
location: complement(334217..334396)
location: region:334217-334396:-1
so has part: feature:334217-334396:-1:exon

NP_010216.1
type: Protein
SIO_000068: ncbiprotein

S000002225
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:334217-334396:-1:exon

YDL066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IDP1
locus tag: YDL066W
so part of: sequence
location: <334835..>336121
location: region:334835-336121:1
so has part: feature:334835-336121:1:exon
subclass of: SO_0000010

851493
type: Gene
SIO_000068: ncbigene

position:334835:1
position: 334835
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:336121:1
position: 336121
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:334835-336121:1:exon

YDL066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IDP1
locus tag: YDL066W
product: isocitrate dehydrogenase (NADP(+)) IDP1
transcript id: NM_001180125.1
SIO_010081: YDL066W
subclass of: SO_0000673
so part of: YDL066W
location: <334835..>336121
location: region:334835-336121:1
so has part: feature:334835-336121:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:334835-336121:1:exon

YDL066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IDP1
locus tag: YDL066W
EC number: 1.1.1.42
experiment: EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:15574419]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15001388|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]
experiment: EXISTENCE:genetic interaction:GO:0006537 glutamate biosynthetic process [PMID:15574419]
experiment: EXISTENCE:mutant phenotype:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:8099357]
note: Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
codon start: 1
product: isocitrate dehydrogenase (NADP(+)) IDP1
translation: MSMLSRRLFSTSRLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE
SIO_010081: YDL066W
subclass of: SO_0000673
so part of: YDL066W
location: 334835..336121
location: region:334835-336121:1
so has part: feature:334835-336121:1:exon

NP_010217.1
type: Protein
SIO_000068: ncbiprotein

S000002224
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:334835-336121:1:exon

YDL065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS12
gene: PEX19
locus tag: YDL065C
gene synonym: PAS12
so part of: sequence
location: complement(<336249..>337277)
location: region:336249-337277:-1
so has part: feature:336249-337277:-1:exon
subclass of: SO_0000010

851494
type: Gene
SIO_000068: ncbigene

position:336249:-1
position: 336249
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337277:-1
position: 337277
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:336249-337277:-1:exon

YDL065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS12
gene: PEX19
locus tag: YDL065C
gene synonym: PAS12
product: Pex19p
transcript id: NM_001180124.1
SIO_010081: YDL065C
subclass of: SO_0000673
so part of: YDL065C
location: complement(<336249..>337277)
location: region:336249-337277:-1
so has part: feature:336249-337277:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:336249-337277:-1:exon

YDL065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS12
gene: PEX19
locus tag: YDL065C
gene synonym: PAS12
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9418908]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16009135]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9418908|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:16679311]
experiment: EXISTENCE:mutant phenotype:GO:0032527 protein exit from endoplasmic reticulum [PMID:16009135]
experiment: EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:20427571]
experiment: EXISTENCE:mutant phenotype:GO:0045046 protein import into peroxisome membrane [PMID:10637226]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16679311|PMID:9418908]
experiment: EXISTENCE:physical interaction:GO:0033328 peroxisome membrane targeting sequence binding [PMID:16679311]
experiment: EXISTENCE:physical interaction:GO:0045033 peroxisome inheritance [PMID:22486971]
experiment: EXISTENCE:physical interaction:GO:0050821 protein stabilization [PMID:16679311]
note: Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning
codon start: 1
product: Pex19p
translation: MNENEYDNFDDLDDLLDEDPTKLDEAEPDDVQAKGSVYNDSENKEKNAESKDSDGVQVANESEEDPELKEMMVDLQNEFANLMKNNGNENNVKTEDFNKLISALEEAAKVPHQQMEQGCSSLKSNSTDKGTVNGSNPGFKNIVSNTLDRLKENGNKVDTSLAEETKESQRSGQNNNIDDILSQLLDQMVASGGKESAENQFDLKDGEMDDAITKILDQMTSKEVLYEPMKEMRSEFGVWFQENGENEEHKEKIGTYKRQFNIVDEIVNIYELKDYDELKHKDRVTELLDELEQLGDSPIRSANSPLKHGNEEEELMKMLEIDGNDPNLGNLDKELTDGCKQQ
SIO_010081: YDL065C
subclass of: SO_0000673
so part of: YDL065C
location: complement(336249..337277)
location: region:336249-337277:-1
so has part: feature:336249-337277:-1:exon

NP_010218.2
type: Protein
SIO_000068: ncbiprotein

S000002223
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:336249-337277:-1:exon

YDL064W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBC9
locus tag: YDL064W
so part of: sequence
location: <337487..>338070
location: region:337487-338070:1
so has part: feature:337487-338070:1:exon
subclass of: SO_0000010

851495
type: Gene
SIO_000068: ncbigene

position:337487:1
position: 337487
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:338070:1
position: 338070
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337487-338070:1:exon

YDL064W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBC9
locus tag: YDL064W
product: E2 SUMO-conjugating protein UBC9
transcript id: NM_001180123.1
SIO_010081: YDL064W
subclass of: SO_0000673
so part of: YDL064W
location: join(<337487..337524,337635..>338070)
location: region:337487-338070:1
so has part: feature:337487-337524:1:exon
so has part: feature:337635-338070:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337487-337524:1:exon

position:337524:1
position: 337524
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:337635-338070:1:exon

position:337635:1
position: 337635
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL064W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBC9
locus tag: YDL064W
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16782016]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7800043]
experiment: EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:9341106|PMID:9435231]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:9341106|PMID:9435231]
experiment: EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:7800043]
experiment: EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:9341106|PMID:9435231]
experiment: EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:9435231]
note: SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
codon start: 1
product: E2 SUMO-conjugating protein UBC9
translation: MSSLCLQRLQEERKKWRKDHPFGFYAKPVKKADGSMDLQKWEAGIPGKEGTNWAGGVYPITVEYPNEYPSKPPKVKFPAGFYHPNVYPSGTICLSILNEDQDWRPAITLKQIVLGVQDLLDSPNPNSPAQEPAWRSFSRNKAEYDKKVLLQAKQYSK
SIO_010081: YDL064W
subclass of: SO_0000673
so part of: YDL064W
location: join(337487..337524,337635..338070)
location: region:337487-338070:1
so has part: feature:337487-337524:1:exon
so has part: feature:337635-338070:1:exon

NP_010219.1
type: Protein
SIO_000068: ncbiprotein

S000002222
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337487-337524:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:337635-338070:1:exon

YDL063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SYO1
locus tag: YDL063C
so part of: sequence
location: complement(<338272..>340134)
location: region:338272-340134:-1
so has part: feature:338272-340134:-1:exon
subclass of: SO_0000010

851497
type: Gene
SIO_000068: ncbigene

position:338272:-1
position: 338272
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340134:-1
position: 340134
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:338272-340134:-1:exon

YDL063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SYO1
locus tag: YDL063C
product: Syo1p
transcript id: NM_001180122.1
SIO_010081: YDL063C
subclass of: SO_0000673
so part of: YDL063C
location: complement(<338272..>340134)
location: region:338272-340134:-1
so has part: feature:338272-340134:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:338272-340134:-1:exon

YDL063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SYO1
locus tag: YDL063C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:23118189]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:19806183]
note: Transport adaptor or symportin; assembly chaperone that co-translationally associates with nascent Rpl5p, preventing aggregation; facilitates synchronized nuclear coimport of two 5S-rRNA binding proteins, Rpl5p and Rpl11p, mediated by import receptor Kap104p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
codon start: 1
product: Syo1p
translation: MGRSKKRSRASSSRLNPLRKAGSNDNNKDTNVVNKKLQPLLQNLSSVVPNDRSIALSSISVLCEDAHMRQLLLKEKLVPIILNKLLNDSNSDIVVESFGLLRNLSLEEGYDVSIYLWRSDIWTSITSNFGRIVESLSALQAAEQQPQLKPAGKSKIESKRLLFDFADNLLSLVVALSNGSDDILNEILTESKINEIFQVISQLLKYGVEKLPINLFNTTLDLIYDLSSESFEFIDHVSNNELLSQFLNGLSPALHPQANELTKVLIEGIHCQFLDMKITYDQCNKMIHSVCHSINNIDPVQLVNDINNPVEIGPATSKDESSKVITKIKDYNAKRNESMIKLQSIEIAIDLITAIIEIVASKYESPESQEVAIPEELINTLTNFLPHVFMILKDTFTSRILIGWNNLIWLFVSLSLTELSGELLTTLWSYVTQLDSQDDLSIKIGRMGCIWALLKLIFPDGAFESENRALINVQMLNNSGFARGIIEEFQNNNDLELQQKCINVLSTYAMIQGQIDANKEIGQFFIQTLTQLNVRPEILIEMTNSLFQIYGDASYDYNEPIFVRGGFLSILKDQVVPNLRQQFKMVDKNKNPELKERCHDCFTTLDSFIHYKMNENSTNQ
SIO_010081: YDL063C
subclass of: SO_0000673
so part of: YDL063C
location: complement(338272..340134)
location: region:338272-340134:-1
so has part: feature:338272-340134:-1:exon

NP_010220.1
type: Protein
SIO_000068: ncbiprotein

S000002221
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:338272-340134:-1:exon

YDL061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS29B
locus tag: YDL061C
so part of: sequence
location: complement(<340628..>340798)
location: region:340628-340798:-1
so has part: feature:340628-340798:-1:exon
subclass of: SO_0000010

851498
type: Gene
SIO_000068: ncbigene

position:340628:-1
position: 340628
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340798:-1
position: 340798
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:340628-340798:-1:exon

YDL061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS29B
locus tag: YDL061C
product: ribosomal 40S subunit protein S29B
transcript id: NM_001180120.1
SIO_010081: YDL061C
subclass of: SO_0000673
so part of: YDL061C
location: complement(<340628..>340798)
location: region:340628-340798:-1
so has part: feature:340628-340798:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:340628-340798:-1:exon

YDL061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS29B
locus tag: YDL061C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:18782943|PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480|PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480|PMID:18782943]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S29B
translation: MAHENVWFSHPRRFGKGSRQCRVCSSHTGLVRKYDLNICRQCFREKANDIGFHKYR
SIO_010081: YDL061C
subclass of: SO_0000673
so part of: YDL061C
location: complement(340628..340798)
location: region:340628-340798:-1
so has part: feature:340628-340798:-1:exon

NP_010222.1
type: Protein
SIO_000068: ncbiprotein

S000002219
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:340628-340798:-1:exon

YDL060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TSR1
locus tag: YDL060W
so part of: sequence
location: <341619..>343985
location: region:341619-343985:1
so has part: feature:341619-343985:1:exon
subclass of: SO_0000010

851499
type: Gene
SIO_000068: ncbigene

position:341619:1
position: 341619
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343985:1
position: 343985
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341619-343985:1:exon

YDL060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TSR1
locus tag: YDL060W
product: Tsr1p
transcript id: NM_001180119.1
SIO_010081: YDL060W
subclass of: SO_0000673
so part of: YDL060W
location: <341619..>343985
location: region:341619-343985:1
so has part: feature:341619-343985:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341619-343985:1:exon

YDL060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TSR1
locus tag: YDL060W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11565749]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15167894|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:15167894]
experiment: EXISTENCE:direct assay:GO:0043021 ribonucleoprotein complex binding [PMID:15167894]
experiment: EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565749]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15167894|PMID:12089522]
note: Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: Tsr1p
translation: MAGHSHRSSLKNGHKSYKSKHASKGALKRLYKGKVEKEPVGTGKPDKQVSKLQRKNKAKQLRAQRILDSIENRKLFEGKNGAAKIITIVPLVNDLDPLDILYKLLKCADDEGIMVQEVDSKRIFNVHIKKFKSNLKIIIPDMTNFLNILDCAKVADFVVFGLSGVQEVDEEFGEQIIRALELQGIASYIGVISNLSAVHEKEKFQLDVKQSLESYFKHFFPSEERVYNLEKNSDALNVLRTLCQRLPRSINWRDNRGYVVADFVDFVETSPDSGDLVIEGTVRGIGFNANRLVHIPDFGDFQLNKIEKISESSQKRKIIKEKATDSLSLELDLQTVFESNMNRDTLDEYAPEGTEDWSDYDEDFEYDGLTTARYDDHGFLPGREQTSKKAAVPKGTSDYQAKWYLDDVIDANEEEEAEQTNGKDETMMEIDDEMMVEQDNEEVAGDEEYDIEDNEGFEELSPEEEERQLREFRDMEKEDREFPDEIELEPSESAIERLKRYRGLKNLYNCDWQVDEKDPSSPAEWKRLLRIGNYKNTKNRIIKETKNEAQAIAGDRIRMFIRFPKFLLEKIQDPKQLLFAVYGLLLHEHKNAVVNFSLQRWEQYDKPVPSQEPIVVQYGVRRYTIQPLFSQGSNSPNNVHKYERFLHPDTVSVATCIAPVDFTQSPAIFFKPSPTDAKNIELIGHGTFLNADHSRILAKRAILTGHPFRFHKTVVTVRYMFFRPEDVEWFKSIPLFTKSGRSGFIKESLGTHGYFKATFDGKLSAQDVVAMSLYKRMWPMPSLPWNGM
SIO_010081: YDL060W
subclass of: SO_0000673
so part of: YDL060W
location: 341619..343985
location: region:341619-343985:1
so has part: feature:341619-343985:1:exon

NP_010223.1
type: Protein
SIO_000068: ncbiprotein

S000002218
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341619-343985:1:exon

YDL059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD59
locus tag: YDL059C
so part of: sequence
location: complement(<344237..>344953)
location: region:344237-344953:-1
so has part: feature:344237-344953:-1:exon
subclass of: SO_0000010

851500
type: Gene
SIO_000068: ncbigene

position:344237:-1
position: 344237
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:344953:-1
position: 344953
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:344237-344953:-1:exon

YDL059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD59
locus tag: YDL059C
product: Rad59p
transcript id: NM_001180118.1
SIO_010081: YDL059C
subclass of: SO_0000673
so part of: YDL059C
location: complement(<344237..>344953)
location: region:344237-344953:-1
so has part: feature:344237-344953:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:344237-344953:-1:exon

YDL059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD59
locus tag: YDL059C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:26540255]
experiment: EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:12368472]
experiment: EXISTENCE:genetic interaction:GO:0045002 double-strand break repair via single-strand annealing [PMID:11606529]
experiment: EXISTENCE:genetic interaction:GO:2000278 regulation of DNA biosynthetic process [PMID:23824283]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]
experiment: EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]
experiment: EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:26540255]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10655498]
note: Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; regulates replication fork progression in DNA ligase I-deficient cells; paralog of Rad52p
codon start: 1
product: Rad59p
translation: MTIQAKPSSSISYDSTTYGTAPGLDIKEFQIIEDWNGRPASAWSVQRIGLLQSKIERYTYNIYHNNKYGKHNLSKLIPGHALIQFANETFGYDGWRMDVIDVEARECQPFTAVNNGENTNTSEVKYTVVAEAQVKVTLKDGTNTQCGGLGRITLSSRGECYNRSKKEAVGDALKKALLSFEKIILDYETKITNNYYVDGLYGSKKIKNEANTNYNLLSATNSKPTFIKLEDAKGTHIK
SIO_010081: YDL059C
subclass of: SO_0000673
so part of: YDL059C
location: complement(344237..344953)
location: region:344237-344953:-1
so has part: feature:344237-344953:-1:exon

NP_010224.1
type: Protein
SIO_000068: ncbiprotein

S000002217
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:344237-344953:-1:exon

YDL058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: INT1
gene: USO1
locus tag: YDL058W
gene synonym: INT1
so part of: sequence
location: <345665..>351037
location: region:345665-351037:1
so has part: feature:345665-351037:1:exon
subclass of: SO_0000010

851501
type: Gene
SIO_000068: ncbigene

position:345665:1
position: 345665
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:351037:1
position: 351037
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:345665-351037:1:exon

YDL058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: INT1
gene: USO1
locus tag: YDL058W
gene synonym: INT1
product: Uso1p
transcript id: NM_001180117.1
SIO_010081: YDL058W
subclass of: SO_0000673
so part of: YDL058W
location: <345665..>351037
location: region:345665-351037:1
so has part: feature:345665-351037:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:345665-351037:1:exon

YDL058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: INT1
gene: USO1
locus tag: YDL058W
gene synonym: INT1
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:17192843]
experiment: EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:17192843]
experiment: EXISTENCE:direct assay:GO:0048211 Golgi vesicle docking [PMID:9545229]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8603910]
experiment: EXISTENCE:mutant phenotype:GO:0035493 SNARE complex assembly [PMID:8603910]
note: Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
codon start: 1
product: Uso1p
translation: MDIIQGLIQQPKIQSVDETIPTLCDRVENSTLISDRRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIRGDGHDDLTRGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQSEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMATRPLKARSALISLPTSISTMVSLLDDMHEPIRDEAILLLMAVVNDSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILKYNTSNQTLFLETGNLPKLAHLLSEPISQDEVFFWNDQRIVNINTALDIVSLTVEPGNTVTTKHQNALLDSSVLMVVLRLAFFHNIPKKVRPVALLTAANMVRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILINWMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKLFFTTDIFMFFFQQDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAADIRIPISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFSSKESPFPRKEYFEFITKTLGKDNYASRIKQFKKDSYFSKVDMNEDSILTPELDETGLPKVYFSTYFIQLFNENIYRIRTALSHDPDEEPINKISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKLIALTNEHKELDEKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVEYKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVEISSDEEDDEEDDEEDEEEGQVA
SIO_010081: YDL058W
subclass of: SO_0000673
so part of: YDL058W
location: 345665..351037
location: region:345665-351037:1
so has part: feature:345665-351037:1:exon

NP_010225.1
type: Protein
SIO_000068: ncbiprotein

S000002216
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:345665-351037:1:exon

YDL057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL057W
so part of: sequence
location: <351434..>352420
location: region:351434-352420:1
so has part: feature:351434-352420:1:exon
subclass of: SO_0000010

851502
type: Gene
SIO_000068: ncbigene

position:351434:1
position: 351434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:352420:1
position: 352420
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:351434-352420:1:exon

YDL057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL057W
product: uncharacterized protein
transcript id: NM_001180116.1
SIO_010081: YDL057W
subclass of: SO_0000673
so part of: YDL057W
location: <351434..>352420
location: region:351434-352420:1
so has part: feature:351434-352420:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:351434-352420:1:exon

YDL057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL057W
note: hypothetical protein; YDL057W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MEKKHVTVQIQSAPPSYIKLEANEKFVYITSTMNGLSYQIAAIVSYPEKRNSSTANKEDGKLLCKENKLALLLHGSQSHKNAIYQTLLAKRLAEFGYWVLRIDFRGQGDSSDNCDPGLGRTLAQDLEDLSTVYQTVSDRSLRVQLYKTSTISLDVVVAHSRGSLAMFKFCLKLHAAESPLPSHLINCAGRYDGRGLIERCTRLHPHWQAEGGFWANGPRNGEYKDFWIPLSETYSIAGVCVPEFATIPQTCSVMSCYGMCDHIVPISAASNYARLFEGRHSLKLIENADHNYYGIEGDPNALGLPIRRGRVNYSPLVVDLIMEYLQDT
SIO_010081: YDL057W
subclass of: SO_0000673
so part of: YDL057W
location: 351434..352420
location: region:351434-352420:1
so has part: feature:351434-352420:1:exon

NP_010226.1
type: Protein
SIO_000068: ncbiprotein

S000002215
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:351434-352420:1:exon

YDL056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MBP1
locus tag: YDL056W
so part of: sequence
location: <352877..>355378
location: region:352877-355378:1
so has part: feature:352877-355378:1:exon
subclass of: SO_0000010

851503
type: Gene
SIO_000068: ncbigene

position:352877:1
position: 352877
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:355378:1
position: 355378
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352877-355378:1:exon

YDL056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MBP1
locus tag: YDL056W
product: transcription factor MBP1
transcript id: NM_001180115.1
SIO_010081: YDL056W
subclass of: SO_0000673
so part of: YDL056W
location: <352877..>355378
location: region:352877-355378:1
so has part: feature:352877-355378:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:352877-355378:1:exon

YDL056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MBP1
locus tag: YDL056W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:8372350]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8372350]
experiment: EXISTENCE:mutant phenotype:GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:8372350]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]
note: Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
codon start: 1
product: transcription factor MBP1
translation: MSNQIYSARYSGVDVYEFIHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQGGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDGSASPPPAPKHHHASKVDRKKAIRSASTSAIMETKRNNKKAEENQFQSSKILGNPTAAPRKRGRPVGSTRGSRRKLGVNLQRSQSDMGFPRPAIPNSSISTTQLPSIRSTMGPQSPTLGILEEERHDSRQQQPQQNNSAQFKEIDLEDGLSSDVEPSQQLQQVFNQNTGFVPQQQSSLIQTQQTESMATSVSSSPSLPTSPGDFADSNPFEERFPGGGTSPIISMIPRYPVTSRPQTSDINDKVNKYLSKLVDYFISNEMKSNKSLPQVLLHPPPHSAPYIDAPIDPELHTAFHWACSMGNLPIAEALYEAGTSIRSTNSQGQTPLMRSSLFHNSYTRRTFPRIFQLLHETVFDIDSQSQTVIHHIVKRKSTTPSAVYYLDVVLSKIKDFSPQYRIELLLNTQDKNGDTALHIASKNGDVVFFNTLVKMGALTTISNKEGLTANEIMNQQYEQMMIQNGTNQHVNSSNTDLNIHVNTNNIETKNDVNSMVIMSPVSPSDYITYPSQIATNISRNIPNVVNSMKQMASIYNDLHEQHDNEIKSLQKTLKSISKTKIQVSLKTLEVLKESSKDENGEAQTNDDFEILSRLQEQNTKKLRKRLIRYKRLIKQKLEYRQTVLLNKLIEDETQATTNNTVEKDNNTLERLELAQELTMLQLQRKNKLSSLVKKFEDNAKIHKYRRIIREGTEMNIEEVDSSLDVILQTLIANNNKNKGAEQIITISNANSHA
SIO_010081: YDL056W
subclass of: SO_0000673
so part of: YDL056W
location: 352877..355378
location: region:352877-355378:1
so has part: feature:352877-355378:1:exon

NP_010227.1
type: Protein
SIO_000068: ncbiprotein

S000002214
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:352877-355378:1:exon

YDL055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MPG1
alternative label: SRB1
alternative label: VIG9
gene: PSA1
locus tag: YDL055C
gene synonym: MPG1; SRB1; VIG9
so part of: sequence
location: complement(<355674..>356759)
location: region:355674-356759:-1
so has part: feature:355674-356759:-1:exon
subclass of: SO_0000010

851504
type: Gene
SIO_000068: ncbigene

position:355674:-1
position: 355674
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:356759:-1
position: 356759
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:355674-356759:-1:exon

YDL055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MPG1
alternative label: SRB1
alternative label: VIG9
gene: PSA1
locus tag: YDL055C
gene synonym: MPG1; SRB1; VIG9
product: mannose-1-phosphate guanylyltransferase
transcript id: NM_001180114.1
SIO_010081: YDL055C
subclass of: SO_0000673
so part of: YDL055C
location: complement(<355674..>356759)
location: region:355674-356759:-1
so has part: feature:355674-356759:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:355674-356759:-1:exon

YDL055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MPG1
alternative label: SRB1
alternative label: VIG9
gene: PSA1
locus tag: YDL055C
gene synonym: MPG1; SRB1; VIG9
EC number: 2.7.7.13
experiment: EXISTENCE:direct assay:GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity [PMID:9195935]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0009298 GDP-mannose biosynthetic process [PMID:9195935]
experiment: EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:11055399]
experiment: EXISTENCE:mutant phenotype:GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity [PMID:9195935]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:9195935]
experiment: EXISTENCE:mutant phenotype:GO:0009298 GDP-mannose biosynthetic process [PMID:9195935]
note: GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
codon start: 1
product: mannose-1-phosphate guanylyltransferase
translation: MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNYRPEVMVETLKKYEKEYGVNITFSVETEPLGTAGPLKLAEDVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIEKETFPILVEEKQLYSFDLEGFWMDVGQPKDFLSGTVLYLNSLAKRQPKKLATGANIVGNALIDPTAKISSTAKIGPDVVIGPNVTIGDGVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEGVTVLGDDVEVKDEIYINGGKVLPHKSISDNVPKEAIIM
SIO_010081: YDL055C
subclass of: SO_0000673
so part of: YDL055C
location: complement(355674..356759)
location: region:355674-356759:-1
so has part: feature:355674-356759:-1:exon

NP_010228.1
type: Protein
SIO_000068: ncbiprotein

S000002213
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:355674-356759:-1:exon

YNCD0003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0003W
so part of: sequence
location: 359577..359672
location: region:359577-359672:1
so has part: feature:359577-359672:1:exon
subclass of: SO_0000663

851505
type: Gene
SIO_000068: ncbigene

position:359577:1
position: 359577
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:359672:1
position: 359672
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359577-359672:1:exon

YNCD0003W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0003W
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCD0003W
subclass of: SO_0000673
so part of: YNCD0003W
location: join(359577..359613,359637..359672)
location: region:359577-359672:1
so has part: feature:359577-359613:1:exon
so has part: feature:359637-359672:1:exon

S000006629
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359577-359613:1:exon

position:359613:1
position: 359613
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:359637-359672:1:exon

position:359637:1
position: 359637
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCH1
locus tag: YDL054C
so part of: sequence
location: complement(<359825..>361285)
location: region:359825-361285:-1
so has part: feature:359825-361285:-1:exon
subclass of: SO_0000010

851506
type: Gene
SIO_000068: ncbigene

position:359825:-1
position: 359825
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361285:-1
position: 361285
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359825-361285:-1:exon

YDL054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCH1
locus tag: YDL054C
product: Mch1p
transcript id: NM_001180113.1
SIO_010081: YDL054C
subclass of: SO_0000673
so part of: YDL054C
location: complement(<359825..>361285)
location: region:359825-361285:-1
so has part: feature:359825-361285:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:359825-361285:-1:exon

YDL054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCH1
locus tag: YDL054C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23708375|PMID:19001347|PMID:26928762]
note: Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport
codon start: 1
product: Mch1p
translation: MPLSKVEHYLSYHTRLLLPHVLSLQSSHRVAYIFSLLSAVSTGFITLISLYSQPWQKHLNYSSWQINTIASMTNLGMYLTPPILGMIADSHGPITLSLLAIIGFIPSYSYLAYVFNHPELSLGGNGDSSFNLSIICFVFIGISTSALYFSALLTCTKLYPHTKLLSISLPTTCYGISSVVGSQLLRIKWFWSSNASSSSSNSDLNLGRVFQTFALVYVVIGLLAWIATSVVSLLHFNEEQDNQKRLDDQTDVEQSPLLERSNHVQEKFTQTMLRIFSDPVTYILAVSILLSLGPLEMFIANMGSLTNLLVQLDAPTLSTKLLSTYALSSTFTRLLTGIVADFFAKKKISIKWILLTFLSLGVCAQLFLLKMTSSASPWGLVPTGSLVGIVYGGLFTVYPTLVLLVWGERSFGTVYGSLLIAPAIGSMIFCMLYAKFYDSRCMSGGGDLRNPSCISAVYKYSSIAFVVSAVLSAVVFWKLKSRKLRI
SIO_010081: YDL054C
subclass of: SO_0000673
so part of: YDL054C
location: complement(359825..361285)
location: region:359825-361285:-1
so has part: feature:359825-361285:-1:exon

NP_010229.1
type: Protein
SIO_000068: ncbiprotein

S000002212
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359825-361285:-1:exon

YDL053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PBP4
locus tag: YDL053C
so part of: sequence
location: complement(<361699..>362256)
location: region:361699-362256:-1
so has part: feature:361699-362256:-1:exon
subclass of: SO_0000010

851507
type: Gene
SIO_000068: ncbigene

position:361699:-1
position: 361699
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:362256:-1
position: 362256
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:361699-362256:-1:exon

YDL053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PBP4
locus tag: YDL053C
product: Pbp4p
transcript id: NM_001180112.1
SIO_010081: YDL053C
subclass of: SO_0000673
so part of: YDL053C
location: complement(<361699..>362256)
location: region:361699-362256:-1
so has part: feature:361699-362256:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:361699-362256:-1:exon

YDL053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PBP4
locus tag: YDL053C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:20368989|PMID:26777405]
note: Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes
codon start: 1
product: Pbp4p
translation: MTTTSTTSVDGRTSSTLKATLSASGPNSNGPTPAVLPQKPKLTGWAQAAAKALPRQQQQQQQARKDDSVAVQPANTKTKTIASTAPPANIKGSSTANGSSTNKKFKRANKQPYNREEVRSYMHKLFQSYTAGEKSHSMKTYKQVLSETASGRVSTATDWGTVSSSKNKNKKYGCLSDIAKVLRNQ
SIO_010081: YDL053C
subclass of: SO_0000673
so part of: YDL053C
location: complement(361699..362256)
location: region:361699-362256:-1
so has part: feature:361699-362256:-1:exon

NP_010230.1
type: Protein
SIO_000068: ncbiprotein

S000002211
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:361699-362256:-1:exon

YDL052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLC1
locus tag: YDL052C
so part of: sequence
location: complement(<362672..>363583)
location: region:362672-363583:-1
so has part: feature:362672-363583:-1:exon
subclass of: SO_0000010

851508
type: Gene
SIO_000068: ncbigene

position:362672:-1
position: 362672
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:363583:-1
position: 363583
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:362672-363583:-1:exon

YDL052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLC1
locus tag: YDL052C
product: 1-acylglycerol-3-phosphate O-acyltransferase SLC1
transcript id: NM_001180111.1
SIO_010081: YDL052C
subclass of: SO_0000673
so part of: YDL052C
location: complement(<362672..>363583)
location: region:362672-363583:-1
so has part: feature:362672-363583:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:362672-363583:-1:exon

YDL052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLC1
locus tag: YDL052C
EC number: 2.3.1.51
EC number: 2.3.1.23
EC number: 2.3.1.n7
experiment: EXISTENCE:direct assay:GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity [PMID:9212466]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:10515935]
experiment: EXISTENCE:genetic interaction:GO:0046474 glycerophospholipid biosynthetic process [PMID:17675291]
note: 1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
codon start: 1
product: 1-acylglycerol-3-phosphate O-acyltransferase SLC1
translation: MSVIGRFLYYLRSVLVVLALAGCGFYGVIASILCTLIGKQHLAQWITARCFYHVMKLMLGLDVKVVGEENLAKKPYIMIANHQSTLDIFMLGRIFPPGCTVTAKKSLKYVPFLGWFMALSGTYFLDRSKRQEAIDTLNKGLENVKKNKRALWVFPEGTRSYTSELTMLPFKKGAFHLAQQGKIPIVPVVVSNTSTLVSPKYGVFNRGCMIVRILKPISTENLTKDKIGEFAEKVRDQMVDTLKEIGYSPAINDTTLPPQAIEYAALQHDKKVNKKIKNEPVPSVSISNDVNTHNEGSSVKKMH
SIO_010081: YDL052C
subclass of: SO_0000673
so part of: YDL052C
location: complement(362672..363583)
location: region:362672-363583:-1
so has part: feature:362672-363583:-1:exon

NP_010231.1
type: Protein
SIO_000068: ncbiprotein

S000002210
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:362672-363583:-1:exon

YDL051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LAH1
alternative label: YLA1
gene: LHP1
locus tag: YDL051W
gene synonym: LAH1; YLA1
so part of: sequence
location: <363952..>364779
location: region:363952-364779:1
so has part: feature:363952-364779:1:exon
subclass of: SO_0000010

851509
type: Gene
SIO_000068: ncbigene

position:363952:1
position: 363952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:364779:1
position: 364779
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:363952-364779:1:exon

YDL051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LAH1
alternative label: YLA1
gene: LHP1
locus tag: YDL051W
gene synonym: LAH1; YLA1
product: Lhp1p
transcript id: NM_001180110.1
SIO_010081: YDL051W
subclass of: SO_0000673
so part of: YDL051W
location: <363952..>364779
location: region:363952-364779:1
so has part: feature:363952-364779:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:363952-364779:1:exon

YDL051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LAH1
alternative label: YLA1
gene: LHP1
locus tag: YDL051W
gene synonym: LAH1; YLA1
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19749380]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7799435]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10564276]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11720288]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11720288]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9150139]
note: RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
codon start: 1
product: Lhp1p
translation: MSEKPQQEEQEKPQSRRNSFAVIEFTPEVLDRCLKQVEFYFSEFNFPYDRFLRTTAEKNDGWVPISTIATFNRMKKYRPVDKVIEALRSSEILEVSADGENVKRRVPLDLTAARNARIEQNQRTLAVMNFPHEDVEASQIPELQENLEAFFKKLGEINQVRLRRDHRNKKFNGTVLVEFKTIPECEAFLKSYSNDDESNEILSYEGKKLSVLTKKQFDLQREASKSKNFSGRSRSFNGHKKKNLPKFPKNKKKNGKEESKEDSSAIADDDEEHKE
SIO_010081: YDL051W
subclass of: SO_0000673
so part of: YDL051W
location: 363952..364779
location: region:363952-364779:1
so has part: feature:363952-364779:1:exon

NP_010232.1
type: Protein
SIO_000068: ncbiprotein

S000002209
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:363952-364779:1:exon

YDL049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KNH1
locus tag: YDL049C
so part of: sequence
location: complement(<365068..>365874)
location: region:365068-365874:-1
so has part: feature:365068-365874:-1:exon
subclass of: SO_0000010

851511
type: Gene
SIO_000068: ncbigene

position:365068:-1
position: 365068
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:365874:-1
position: 365874
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:365068-365874:-1:exon

YDL049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KNH1
locus tag: YDL049C
product: Knh1p
transcript id: NM_001180108.1
SIO_010081: YDL049C
subclass of: SO_0000673
so part of: YDL049C
location: complement(<365068..>365874)
location: region:365068-365874:-1
so has part: feature:365068-365874:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:365068-365874:-1:exon

YDL049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KNH1
locus tag: YDL049C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:8810042]
experiment: EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:8810042]
note: Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
codon start: 1
product: Knh1p
translation: MLIVLFLTLFCSVVFRTAYCDVAIVAPEPNSVYDLSGTSQAVVKVKWMHTDNTPQEKDFVRYTFTLCSGTNAMIEAMATLQTLSASDLTDNEFNAIIENTVGTDGVYFIQVFAQTAIGYTIHYTNRFKLKGMIGTKAANPSMITIAPEAQTRITTGDVGATIDSKSFTVPYNLQTGVVKYAPMQLQPATKVTAKTWKRKYATSEVTYYYTLRNSVDQHTTVTPGWSYIITADSNYATPAPMPADNGGWYNPRKRLSLTARKVNALRHR
SIO_010081: YDL049C
subclass of: SO_0000673
so part of: YDL049C
location: complement(365068..365874)
location: region:365068-365874:-1
so has part: feature:365068-365874:-1:exon

NP_010234.1
type: Protein
SIO_000068: ncbiprotein

S000002207
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:365068-365874:-1:exon

YDL048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STP4
locus tag: YDL048C
so part of: sequence
location: complement(<366739..>368211)
location: region:366739-368211:-1
so has part: feature:366739-368211:-1:exon
subclass of: SO_0000010

851512
type: Gene
SIO_000068: ncbigene

position:366739:-1
position: 366739
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:368211:-1
position: 368211
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366739-368211:-1:exon

YDL048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STP4
locus tag: YDL048C
product: Stp4p
transcript id: NM_001180107.1
SIO_010081: YDL048C
subclass of: SO_0000673
so part of: YDL048C
location: complement(<366739..>368211)
location: region:366739-368211:-1
so has part: feature:366739-368211:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366739-368211:-1:exon

YDL048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STP4
locus tag: YDL048C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
note: Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication
codon start: 1
product: Stp4p
translation: MLVSSSFASSIDSVMSHETMSLRRNPPFIDTPEKMPNPTASPNGTIHHLIDPSLPLLSSTTSSSRSTLSSTLNSPPPPPLTTSYSSYNSSACQSITSSPTDNTALAHNSKCYFPHSLSPTPLSSNSSSHVILPPISSFTNLITVAEREFNGRSNSLHANFTSPVPRTVLDHHRHELTFCNPNNTTGFKTITPSPPTQHQSILPTAVDNVPRSKSVSSLPVSGFPPLIVKQQQQQQLNSSSSASALPSIHSPLTNEHTSRYSSSLKDSAKITKQRKKKECPICHNFYANLSTHKSTHLTPEDRPHKCPICQRGFARNNDLIRHKKRHWKDEFMQIYARESDNNSGADDQDDTARTSANNDSDDSNDKLAASSSSEETKLLKKNQLKSLYKIKGAFKCPYNSTLINLDMEVYPHKSRSLYFEPINCHQTGVFSRCDTFKNHLKALHFEYPPKTKKEDRGVVPGKCKHCGLQFPNVDVWLNKHVGKGCGYSYH
SIO_010081: YDL048C
subclass of: SO_0000673
so part of: YDL048C
location: complement(366739..368211)
location: region:366739-368211:-1
so has part: feature:366739-368211:-1:exon

NP_010235.1
type: Protein
SIO_000068: ncbiprotein

S000002206
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366739-368211:-1:exon

YDL047W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PPH1
gene: SIT4
locus tag: YDL047W
gene synonym: PPH1
so part of: sequence
location: <369771..>370706
location: region:369771-370706:1
so has part: feature:369771-370706:1:exon
subclass of: SO_0000010

851513
type: Gene
SIO_000068: ncbigene

position:369771:1
position: 369771
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370706:1
position: 370706
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:369771-370706:1:exon

YDL047W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PPH1
gene: SIT4
locus tag: YDL047W
gene synonym: PPH1
product: type 2A-related serine/threonine-protein phosphatase SIT4
transcript id: NM_001180106.1
SIO_010081: YDL047W
subclass of: SO_0000673
so part of: YDL047W
location: <369771..>370706
location: region:369771-370706:1
so has part: feature:369771-370706:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:369771-370706:1:exon

YDL047W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PPH1
gene: SIT4
locus tag: YDL047W
gene synonym: PPH1
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1848673|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:1848673]
experiment: EXISTENCE:mutant phenotype:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]
experiment: EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]
experiment: EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:23864707]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15150670]
experiment: EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12080055]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18357452]
experiment: EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:12080055]
experiment: EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:12080055]
experiment: EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:10604478|PMID:12820961]
note: Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6
codon start: 1
product: type 2A-related serine/threonine-protein phosphatase SIT4
translation: MVSRGPDEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDYIRESTANHNNQRAGYFL
SIO_010081: YDL047W
subclass of: SO_0000673
so part of: YDL047W
location: 369771..370706
location: region:369771-370706:1
so has part: feature:369771-370706:1:exon

NP_010236.1
type: Protein
SIO_000068: ncbiprotein

S000002205
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:369771-370706:1:exon

YDL046W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NPC2
locus tag: YDL046W
so part of: sequence
location: <371240..>371761
location: region:371240-371761:1
so has part: feature:371240-371761:1:exon
subclass of: SO_0000010

851514
type: Gene
SIO_000068: ncbigene

position:371240:1
position: 371240
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371761:1
position: 371761
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371240-371761:1:exon

YDL046W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NPC2
locus tag: YDL046W
product: sterol transporter
transcript id: NM_001180105.1
SIO_010081: YDL046W
subclass of: SO_0000673
so part of: YDL046W
location: <371240..>371761
location: region:371240-371761:1
so has part: feature:371240-371761:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:371240-371761:1:exon

YDL046W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NPC2
locus tag: YDL046W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:16278452]
experiment: EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:33141558]
experiment: EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:31543266]
experiment: EXISTENCE:direct assay:GO:0031210 phosphatidylcholine binding [PMID:33141558]
experiment: EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:31543266]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:33141558]
experiment: EXISTENCE:genetic interaction:GO:0032366 intracellular sterol transport [PMID:16278452]
note: Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general 'lipid solubilizer', binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2
codon start: 1
product: sterol transporter
translation: MTHSLKALFALLFLYTAAVNAGVIGIFNALPPPNTKPINGESPLYQCDILDKQLVEIKEVNLDPNPPVRGENLTISANGEVFETIEEGAYIDVEVRLGYIRLLSQTFDLCETLEDNDIEGLSCPIEPGEYNIKKIVEIPGEVPPGKYVVVARAYTEKDDLITCLTGEVIFPPR
SIO_010081: YDL046W
subclass of: SO_0000673
so part of: YDL046W
location: 371240..371761
location: region:371240-371761:1
so has part: feature:371240-371761:1:exon

NP_010237.1
type: Protein
SIO_000068: ncbiprotein

S000002204
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:371240-371761:1:exon

YDL045W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mS37
gene: MRP10
locus tag: YDL045W-A
gene synonym: mS37
so part of: sequence
location: <372248..>372535
location: region:372248-372535:1
so has part: feature:372248-372535:1:exon
subclass of: SO_0000010

851515
type: Gene
SIO_000068: ncbigene

position:372248:1
position: 372248
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:372535:1
position: 372535
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372248-372535:1:exon

YDL045W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mS37
gene: MRP10
locus tag: YDL045W-A
gene synonym: mS37
product: mitochondrial 37S ribosomal protein YmS-T
transcript id: NM_001184304.1
SIO_010081: YDL045W-A
subclass of: SO_0000673
so part of: YDL045W-A
location: <372248..>372535
location: region:372248-372535:1
so has part: feature:372248-372535:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372248-372535:1:exon

YDL045W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mS37
gene: MRP10
locus tag: YDL045W-A
gene synonym: mS37
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9065385|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9065385|PMID:9151978]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9065385]
note: Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria
codon start: 1
product: mitochondrial 37S ribosomal protein YmS-T
translation: MSGKPPVYRLPPLPRLKVKKPIIRQEANKCLVLMSNLLQCWSSYGHMSPKCAGLVTELKSCTSESALGKRNNVQKSNINYHAARLYDRINGKPHD
SIO_010081: YDL045W-A
subclass of: SO_0000673
so part of: YDL045W-A
location: 372248..372535
location: region:372248-372535:1
so has part: feature:372248-372535:1:exon

NP_010238.1
type: Protein
SIO_000068: ncbiprotein

S000006430
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372248-372535:1:exon

YDL045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAD1
locus tag: YDL045C
so part of: sequence
location: complement(<372688..>373608)
location: region:372688-373608:-1
so has part: feature:372688-373608:-1:exon
subclass of: SO_0000010

851516
type: Gene
SIO_000068: ncbigene

position:372688:-1
position: 372688
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:373608:-1
position: 373608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372688-373608:-1:exon

YDL045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAD1
locus tag: YDL045C
product: FMN adenylyltransferase
transcript id: NM_001180104.1
SIO_010081: YDL045C
subclass of: SO_0000673
so part of: YDL045C
location: complement(<372688..>373608)
location: region:372688-373608:-1
so has part: feature:372688-373608:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372688-373608:-1:exon

YDL045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAD1
locus tag: YDL045C
EC number: 2.7.7.2
experiment: EXISTENCE:direct assay:GO:0003919 FMN adenylyltransferase activity [PMID:7799934]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7799934]
experiment: EXISTENCE:direct assay:GO:0006747 FAD biosynthetic process [PMID:7799934]
experiment: EXISTENCE:mutant phenotype:GO:0006747 FAD biosynthetic process [PMID:7799934]
note: Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1
codon start: 1
product: FMN adenylyltransferase
translation: MQLSKAAEMCYEITNSYLHIDQKSQIIASTQEAIRLTRKYLLSEIFVRWSPLNGEISFSYNGGKDCQVLLLLYLSCLWEYFFIKAQNSQFDFEFQSFPMQRLPTVFIDQEETFPTLENFVLETSERYCLSLYESQRQSGASVNMADAFRDFIKIYPETEAIVIGIRHTDPFGEALKPIQRTDSNWPDFMRLQPLLHWDLTNIWSFLLYSNEPICGLYGKGFTSIGGINNSLPNPHLRKDSNNPALHFEWEIIHAFGKDAEGERSSAINTSPISVVDKERFSKYHDNYYPGWYLVDDTLERAGRIKN
SIO_010081: YDL045C
subclass of: SO_0000673
so part of: YDL045C
location: complement(372688..373608)
location: region:372688-373608:-1
so has part: feature:372688-373608:-1:exon

NP_010239.1
type: Protein
SIO_000068: ncbiprotein

S000002203
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372688-373608:-1:exon

YDL044C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAM1
gene: MTF2
locus tag: YDL044C
gene synonym: NAM1
so part of: sequence
location: complement(<373967..>375289)
location: region:373967-375289:-1
so has part: feature:373967-375289:-1:exon
subclass of: SO_0000010

851517
type: Gene
SIO_000068: ncbigene

position:373967:-1
position: 373967
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:375289:-1
position: 375289
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:373967-375289:-1:exon

YDL044C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAM1
gene: MTF2
locus tag: YDL044C
gene synonym: NAM1
product: Mtf2p
transcript id: NM_001180103.1
SIO_010081: YDL044C
subclass of: SO_0000673
so part of: YDL044C
location: complement(<373967..>375289)
location: region:373967-375289:-1
so has part: feature:373967-375289:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:373967-375289:-1:exon

YDL044C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAM1
gene: MTF2
locus tag: YDL044C
gene synonym: NAM1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8200349|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:8413192]
experiment: EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:8413192]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12637560]
note: Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
codon start: 1
product: Mtf2p
translation: MIRTSSILKNCNYRYIHCIHRCLLNEANLKDRKTHNVERVSNEKTFEQALEEERKVFGELFEAGARVENMRHTNASKIIDKYYNGLQDNSEGTSVKKEKIVFNHSQRAQRKLPNKDHEFLKETAGNDYVYERAEPSAISTKTISEQTRTLLEKIFDEDNSINKSNRELLNLNLRKGSGMEALRQPVAHSNVKFSEEVMQEIGNKIRYQTTLDQVLEPHIDYLREAVKSDYDLLRYLKQSLDIYKKRNKDLELKMNAESSNIFEDIRSACINKPAELPKPLAMTLPYIIVKSLRLGDFDFPADRKYTLISYVYNECKNNMDASLYLTICNVDFYNLLVQLLWENFQEIRYLRRVVTEMSVNGVIGNIETVDILDKIVKEMRSLNEDVFLEAGEQLSADEEVSSSANKIVNVGVLWNKDTNNDLLIVENYLKSLKKNLTRDR
SIO_010081: YDL044C
subclass of: SO_0000673
so part of: YDL044C
location: complement(373967..375289)
location: region:373967-375289:-1
so has part: feature:373967-375289:-1:exon

NP_010240.1
type: Protein
SIO_000068: ncbiprotein

S000002202
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:373967-375289:-1:exon

YDL043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RNA11
gene: PRP11
locus tag: YDL043C
gene synonym: RNA11
so part of: sequence
location: complement(<375680..>376480)
location: region:375680-376480:-1
so has part: feature:375680-376480:-1:exon
subclass of: SO_0000010

851518
type: Gene
SIO_000068: ncbigene

position:375680:-1
position: 375680
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:376480:-1
position: 376480
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:375680-376480:-1:exon

YDL043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RNA11
gene: PRP11
locus tag: YDL043C
gene synonym: RNA11
product: Prp11p
transcript id: NM_001180102.1
SIO_010081: YDL043C
subclass of: SO_0000673
so part of: YDL043C
location: complement(<375680..>376480)
location: region:375680-376480:-1
so has part: feature:375680-376480:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:375680-376480:-1:exon

YDL043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RNA11
gene: PRP11
locus tag: YDL043C
gene synonym: RNA11
experiment: EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:8969185]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8065365]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
note: Subunit of the SF3a splicing factor complex; required for spliceosome assembly
codon start: 1
product: Prp11p
translation: MNYLEGVGSKKGGGGIASESQFNLQRRKEVESLLSKGENVPYTFQDEKDDQVRSNPYIYKNHSGKLVCKLCNTMHMSWSSVERHLGGKKHGLNVLRRGISIEKSSLGREGQTTHDFRQQQKIIEAKQSLKNNGTIPVCKIATVKNPKNGSVGLAIQVNYSSEVKENSVDSDDKAKVPPLIRIVSGLELSDTKQKGKKFLVIAYEPFENIAIELPPNEILFSENNDMDNNNDGVDELNKKCTFWDAISKLYYVQFFFKQAEQEQADV
SIO_010081: YDL043C
subclass of: SO_0000673
so part of: YDL043C
location: complement(375680..376480)
location: region:375680-376480:-1
so has part: feature:375680-376480:-1:exon

NP_010241.1
type: Protein
SIO_000068: ncbiprotein

S000002201
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:375680-376480:-1:exon

YDL042C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAR1
gene: SIR2
locus tag: YDL042C
gene synonym: MAR1
so part of: sequence
location: complement(<376757..>378445)
location: region:376757-378445:-1
so has part: feature:376757-378445:-1:exon
subclass of: SO_0000010

851520
type: Gene
SIO_000068: ncbigene

position:376757:-1
position: 376757
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:378445:-1
position: 378445
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:376757-378445:-1:exon

YDL042C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAR1
gene: SIR2
locus tag: YDL042C
gene synonym: MAR1
product: NAD-dependent histone deacetylase SIR2
transcript id: NM_001180101.1
SIO_010081: YDL042C
subclass of: SO_0000673
so part of: YDL042C
location: complement(<376757..>378445)
location: region:376757-378445:-1
so has part: feature:376757-378445:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:376757-378445:-1:exon

YDL042C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAR1
gene: SIR2
locus tag: YDL042C
gene synonym: MAR1
EC number: 2.3.1.286
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9710643]
experiment: EXISTENCE:direct assay:GO:0000792 heterochromatin [PMID:20176978]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:29795547]
experiment: EXISTENCE:direct assay:GO:0005677 chromatin silencing complex [PMID:9122169]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9214640]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:11553718]
experiment: EXISTENCE:direct assay:GO:0017136 NAD-dependent histone deacetylase activity [PMID:10811920]
experiment: EXISTENCE:direct assay:GO:0030869 RENT complex [PMID:10219244]
experiment: EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:19217406]
experiment: EXISTENCE:direct assay:GO:0032041 NAD-dependent histone H3K14 deacetylase activity [PMID:10693811]
experiment: EXISTENCE:direct assay:GO:0046969 NAD-dependent histone H3K9 deacetylase activity [PMID:10693811]
experiment: EXISTENCE:direct assay:GO:0046970 NAD-dependent histone H4K16 deacetylase activity [PMID:10693811]
experiment: EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:26951198]
experiment: EXISTENCE:genetic interaction:GO:0045910 negative regulation of DNA recombination [PMID:16182251]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:2647300]
experiment: EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103]
experiment: EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]
experiment: EXISTENCE:mutant phenotype:GO:0008156 negative regulation of DNA replication [PMID:15082529]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11950950|PMID:3297920]
experiment: EXISTENCE:mutant phenotype:GO:0031494 regulation of mating type switching [PMID:31461456]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:1913809|PMID:9501103|PMID:11950950]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:27122604]
experiment: EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:25822194]
experiment: EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:26218225]
experiment: EXISTENCE:mutant phenotype:GO:0097752 regulation of DNA stability [PMID:27820830]
experiment: EXISTENCE:mutant phenotype:GO:1904524 negative regulation of DNA amplification [PMID:26195783]
note: Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication, suppressing early firing of multicopy rDNA origins; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
codon start: 1
product: NAD-dependent histone deacetylase SIR2
translation: MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
SIO_010081: YDL042C
subclass of: SO_0000673
so part of: YDL042C
location: complement(376757..378445)
location: region:376757-378445:-1
so has part: feature:376757-378445:-1:exon

NP_010242.1
type: Protein
SIO_000068: ncbiprotein

S000002200
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:376757-378445:-1:exon

YDL040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AAA1
alternative label: NAA15
gene: NAT1
locus tag: YDL040C
gene synonym: AAA1; NAA15
so part of: sequence
location: complement(<378874..>381438)
location: region:378874-381438:-1
so has part: feature:378874-381438:-1:exon
subclass of: SO_0000010

851521
type: Gene
SIO_000068: ncbigene

position:378874:-1
position: 378874
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:381438:-1
position: 381438
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378874-381438:-1:exon

YDL040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AAA1
alternative label: NAA15
gene: NAT1
locus tag: YDL040C
gene synonym: AAA1; NAA15
product: peptide alpha-N-acetyltransferase complex A subunit NAT1
transcript id: NM_001180099.1
SIO_010081: YDL040C
subclass of: SO_0000673
so part of: YDL040C
location: complement(<378874..>381438)
location: region:378874-381438:-1
so has part: feature:378874-381438:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:378874-381438:-1:exon

YDL040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AAA1
alternative label: NAA15
gene: NAT1
locus tag: YDL040C
gene synonym: AAA1; NAA15
experiment: EXISTENCE:direct assay:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:2551674]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]
experiment: EXISTENCE:direct assay:GO:0031415 NatA complex [PMID:14517307]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:14517307]
experiment: EXISTENCE:mutant phenotype:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:2551674]
experiment: EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]
note: Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progression, heat-shock resistance, mating, sporulation, telomeric silencing and early stages of mitophagy; orthologous to human NAA15; expression of both human NAA10 and NAA15 functionally complements ard1 nat1 double mutant although single mutations are not complemented by their orthologs
codon start: 1
product: peptide alpha-N-acetyltransferase complex A subunit NAT1
translation: MSRKRSTKPKPAAKIALKKENDQFLEALKLYEGKQYKKSLKLLDAILKKDGSHVDSLALKGLDLYSVGEKDDAASYVANAIRKIEGASASPICCHVLGIYMRNTKEYKESIKWFTAALNNGSTNKQIYRDLATLQSQIGDFKNALVSRKKYWEAFLGYRANWTSLAVAQDVNGERQQAINTLSQFEKLAEGKISDSEKYEHSECLMYKNDIMYKAASDNQDKLQNVLKHLNDIEPCVFDKFGLLERKATIYMKLGQLKDASIVYRTLIKRNPDNFKYYKLLEVSLGIQGDNKLKKALYGKLEQFYPRCEPPKFIPLTFLQDKEELSKKLREYVLPQLERGVPATFSNVKPLYQRRKSKVSPLLEKIVLDYLSGLDPTQDPIPFIWTNYYLSQHFLFLKDFPKAQEYIDAALDHTPTLVEFYILKARILKHLGLMDTAAGILEEGRQLDLQDRFINCKTVKYFLRANNIDKAVEVASLFTKNDDSVNGIKDLHLVEASWFIVEQAEAYYRLYLDRKKKLDDLASLKKEVESDKSEQIANDIKENQWLVRKYKGLALKRFNAIPKFYKQFEDDQLDFHSYCMRKGTPRAYLEMLEWGKALYTKPMYVRAMKEASKLYFQMHDDRLKRKSDSLDENSDEIQNNGQNSSSQKKKAKKEAAAMNKRKETEAKSVAAYPSDQDNDVFGEKLIETSTPMEDFATEFYNNYSMQVREDERDYILDFEFNYRIGKLALCFASLNKFAKRFGTTSGLFGSMAIVLLHATRNDTPFDPILKKVVTKSLEKEYSENFPLNEISNNSFDWLNFYQEKFGKNDINGLLFLYRYRDDVPIGSSNLKEMIISSLSPLEPHSQNEILQYYL
SIO_010081: YDL040C
subclass of: SO_0000673
so part of: YDL040C
location: complement(378874..381438)
location: region:378874-381438:-1
so has part: feature:378874-381438:-1:exon

NP_010244.1
type: Protein
SIO_000068: ncbiprotein

S000002198
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:378874-381438:-1:exon

YDL039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YDL038C
gene: PRM7
locus tag: YDL039C
gene synonym: YDL038C
so part of: sequence
location: complement(<381985..>384081)
location: region:381985-384081:-1
so has part: feature:381985-384081:-1:exon
subclass of: SO_0000010

851522
type: Gene
SIO_000068: ncbigene

position:381985:-1
position: 381985
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384081:-1
position: 384081
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381985-384081:-1:exon

YDL039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YDL038C
gene: PRM7
locus tag: YDL039C
gene synonym: YDL038C
product: pheromone-regulated protein PRM7
transcript id: NM_001180098.1
SIO_010081: YDL039C
subclass of: SO_0000673
so part of: YDL039C
location: complement(<381985..>384081)
location: region:381985-384081:-1
so has part: feature:381985-384081:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:381985-384081:-1:exon

YDL039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YDL038C
gene: PRM7
locus tag: YDL039C
gene synonym: YDL038C
note: Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the IMI1
codon start: 1
product: pheromone-regulated protein PRM7
translation: MYRTRSSDEVTTSTDLTSSSDVATSVDPTTSVISSTSADPTTSADSTTSTVQTTSAGPSNNIGNSTLANSTTFAVSSTSIDPTSSSDVITSTVQTTSIEPTTSLVSSNDITTSTSLNISVVISTSTDSTSLIESTTTVGPHASSSVAGMYRTRSSDEVTTSTDPTSSSDVATSADPTSSSAVTTLVDPTTSVVISTSVDQTSSSDVATSVDPTTSVISSTSADPTTSADSTTSTVQTTSVDPTSSVVSSAPVDPASSVVSLTSSYPTSSSTVTISANSNGSATLAAQTTSIDPVSSIVSSSGATTIISSASIDPASSVVSSTSSEPTSFIVSSTSVYSTRPSGPTTSTDLATFSDTIILRVSTTSTSQDTQTVSSSLTDMVSSTGSADLSVSSIQRSQVDPSTFAVSNSPVYPTASTGSTSTGIPIASESLSLSRQQGISATSSSSIVTLTPVDSASSSRSSATSIIKPNMPVSSNDSKTQSSVSVVDAFQSTKSSYPSITSADPTTLASENGLVGSSSSAHPITLDRTYASAHASVTDIVSRVTDSTRHTTLVTSNINIQSEVGNPNYSGPKDTTITKQSAFMTSPASTSTISNVQSTASVMNHSIEDNISAAASLESVSGTSTKDYSSQSSAIHYTNSFTTTTTNAFITSKHSIAAVSTGAITSSASISLIMEGSANIEAVGKLVWLAAALPLAFI
SIO_010081: YDL039C
subclass of: SO_0000673
so part of: YDL039C
location: complement(381985..384081)
location: region:381985-384081:-1
so has part: feature:381985-384081:-1:exon

NP_010245.2
type: Protein
SIO_000068: ncbiprotein

S000002197
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:381985-384081:-1:exon

YDL037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BSC1
locus tag: YDL037C
so part of: sequence
location: complement(<384601..>385587)
location: region:384601-385587:-1
so has part: feature:384601-385587:-1:exon
subclass of: SO_0000010

851524
type: Gene
SIO_000068: ncbigene

position:384601:-1
position: 384601
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:385587:-1
position: 385587
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:384601-385587:-1:exon

YDL037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BSC1
locus tag: YDL037C
product: Bsc1p
transcript id: NM_001180096.1
SIO_010081: YDL037C
subclass of: SO_0000673
so part of: YDL037C
location: complement(<384601..>385587)
location: region:384601-385587:-1
so has part: feature:384601-385587:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:384601-385587:-1:exon

YDL037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BSC1
locus tag: YDL037C
note: Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the gene IMI1
codon start: 1
product: Bsc1p
translation: MSQQNILHYDMDVTSVSWVKDNTYQITIHVKAVKDIPLKYLWSLKIIGVNGPSSTVQLYGKNEKTYLISDPTDFTSTFQVYAYPSSDGCTVWMPNFQIQFEYLQGDAAQYWQTWQWGTTTFDLSTGCNNYDNQGHSQTDFPGFYWTYQCKGNNDGTCTKASSSSITTSSITTSSTTTSSTTTSSTTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTTSSSTKTSTTTSSTVKSSSTTSIDFTTSVDSHTSSSVADIYRSRTSTDVTTLAASTSPFSSFTSSDSSSSSDVTSSTIQTTSVDPTT
SIO_010081: YDL037C
subclass of: SO_0000673
so part of: YDL037C
location: complement(384601..385587)
location: region:384601-385587:-1
so has part: feature:384601-385587:-1:exon

NP_010247.1
type: Protein
SIO_000068: ncbiprotein

S000002195
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:384601-385587:-1:exon

YDL036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUS9
locus tag: YDL036C
so part of: sequence
location: complement(<387513..>388901)
location: region:387513-388901:-1
so has part: feature:387513-388901:-1:exon
subclass of: SO_0000010

851525
type: Gene
SIO_000068: ncbigene

position:387513:-1
position: 387513
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388901:-1
position: 388901
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387513-388901:-1:exon

YDL036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUS9
locus tag: YDL036C
product: pseudouridine synthase PUS9
transcript id: NM_001180095.1
SIO_010081: YDL036C
subclass of: SO_0000673
so part of: YDL036C
location: complement(<387513..>388901)
location: region:387513-388901:-1
so has part: feature:387513-388901:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387513-388901:-1:exon

YDL036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUS9
locus tag: YDL036C
EC number: 5.4.99.28
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:15466869]
experiment: EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:15466869]
experiment: EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:15466869]
experiment: EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]
note: Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication
codon start: 1
product: pseudouridine synthase PUS9
translation: MQRNNRLRNLFTVPVIMARQLKRNALSAGLAFAGNATSNEFDEHLQNEVEREREIQKKKKIKRTQSKKSPDLINKSTFQSRTIGSKKEKHRQLDPEYEIVIDGPLRKIKPYHFTYRTFCKERWRDKKLVDVFISEFRDRESEYYKRTIENGDVHINDETADLSTVIRNGDLITHQVHRHEPPVTSRPIKVIFEDDNIMVIDKPSGIPVHPTGRYRFNTITKMLQNNLGFVVNPCNRLDRLTSGLMFLAKTPKGADNIGDQLKAREVTKEYVAKVVGEFPETEVIVEKPLKLIEPRLALNAVCQMDEKGAKHAKTVFNRISYDGKTSIVKCKPLTGRSHQIRVHLQYLGHPIANDPIYSNDEVWGNNLGKGGQADFDIVITKLDEIGKRKPAKSWFHSNGGYGEVLRQEKCSICESDLYTDPGPNDLDLWLHAYLYESTETEEGTEKKKWCYKTEYPEWALRR
SIO_010081: YDL036C
subclass of: SO_0000673
so part of: YDL036C
location: complement(387513..388901)
location: region:387513-388901:-1
so has part: feature:387513-388901:-1:exon

NP_010248.1
type: Protein
SIO_000068: ncbiprotein

S000002194
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387513-388901:-1:exon

YDL035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPR1
locus tag: YDL035C
so part of: sequence
location: complement(<389172..>392057)
location: region:389172-392057:-1
so has part: feature:389172-392057:-1:exon
subclass of: SO_0000010

851527
type: Gene
SIO_000068: ncbigene

position:389172:-1
position: 389172
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:392057:-1
position: 392057
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:389172-392057:-1:exon

YDL035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPR1
locus tag: YDL035C
product: Gpr1p
transcript id: NM_001180094.1
SIO_010081: YDL035C
subclass of: SO_0000673
so part of: YDL035C
location: complement(<389172..>392057)
location: region:389172-392057:-1
so has part: feature:389172-392057:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:389172-392057:-1:exon

YDL035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPR1
locus tag: YDL035C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10655215|PMID:9524122|PMID:9388468]
experiment: EXISTENCE:genetic interaction:GO:0009757 hexose mediated signaling [PMID:9813141]
experiment: EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:10361302]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]
experiment: EXISTENCE:mutant phenotype:GO:0004930 G protein-coupled receptor activity [PMID:9524122]
experiment: EXISTENCE:mutant phenotype:GO:0005536 glucose binding [PMID:15494315]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:10655215]
experiment: EXISTENCE:mutant phenotype:GO:0007186 G protein-coupled receptor signaling pathway [PMID:9524122]
experiment: EXISTENCE:mutant phenotype:GO:0009731 detection of sucrose stimulus [PMID:15494315]
experiment: EXISTENCE:mutant phenotype:GO:0009745 sucrose mediated signaling [PMID:15494315]
experiment: EXISTENCE:mutant phenotype:GO:0009757 hexose mediated signaling [PMID:10655215|PMID:9813141]
experiment: EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:10361302|PMID:15494315|PMID:9813141]
experiment: EXISTENCE:mutant phenotype:GO:0051594 detection of glucose [PMID:15494315]
experiment: EXISTENCE:physical interaction:GO:0004930 G protein-coupled receptor activity [PMID:9388468|PMID:9524122]
experiment: EXISTENCE:physical interaction:GO:0007186 G protein-coupled receptor signaling pathway [PMID:9388468|PMID:9524122]
note: Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
codon start: 1
product: Gpr1p
translation: MITEGFPPNLNALKGSSLLEKRVDSLRQLNTTTVNQLLGLPGMTSTFTAPQLLQLRIIAITASAVSLIAGCLGMFFLSKMDKRRKVFRHDLIAFLIICDFLKAFILMIYPMIILINNSVYATPAFFNTLGWFTAFAIEGADMAIMIFAIHFAILIFKPNWKWRNKRSGNMEGGLYKKRSYIWPITALVPAILASLAFINYNKLNDDSDTTIILDNNNYNFPDSPRQGGYKPWSAWCYLPPKPYWYKIVLSWGPRYFIIIFIFAVYLSIYIFITSESKRIKAQIGDFNHNVLEEEKEKKKLFGLGHWGKAKWYFRSYFKLPLLHLLRNLKNFFTISFIDPNEETDDSGSSNGTFNFGESSNEIPTLFRKTNTGSDENVSASGGVRLLDYNSAKPLDMSKYAMSEQPDLERNNPFDCENDITLNPSELVSKQKEHKVTFSVENEGLDTRKSSMLGHQTFSCQNSLESPLAMYDNKNDNSDITSNIKEKGGIINNNSNNDDDDNNNNNDNDNDNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNIKNNVDNNNTNPADNIPTLSNEAFTPSQQFSQERVNNNADRCENSSFTNVQQHFQAQTYKQMKKRRAQIQKNLRAIFIYPLSYIGIWLFPIIADALQYNHEIKHGPTMWVTYIDTCVRPLSCLVDVIVYLFKEKPWNYSWAKTESKYLIEKYILKGELGEKEILKFCHSNWGKRGWYYRGKWKKRKCWKYSTNPLKRILWFVERFFKQLFELKLHFSFYDNCDDFEYWENYYSAKDSNDNKRTESDETKTNSSDRSLPSNSLELQAMLNNITAEEVEVPLFWRIIHHIPMLGGIDLDELNRLLKIRYNNDHFSLPGLKFALNQNKSHDKHQDVSTNSMVKSSFFSSNIVTNDDENSIEEDKNLRYSDASASENYLVKPTIPGTTPDPIIEAQNDNDSSDSSGIDLIAFLRNGPL
SIO_010081: YDL035C
subclass of: SO_0000673
so part of: YDL035C
location: complement(389172..392057)
location: region:389172-392057:-1
so has part: feature:389172-392057:-1:exon

NP_010249.1
type: Protein
SIO_000068: ncbiprotein

S000002193
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:389172-392057:-1:exon

YDL033C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MTO2
alternative label: MTU1
gene: SLM3
locus tag: YDL033C
gene synonym: MTO2; MTU1
so part of: sequence
location: complement(<392659..>393912)
location: region:392659-393912:-1
so has part: feature:392659-393912:-1:exon
subclass of: SO_0000010

851529
type: Gene
SIO_000068: ncbigene

position:392659:-1
position: 392659
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393912:-1
position: 393912
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392659-393912:-1:exon

YDL033C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MTO2
alternative label: MTU1
gene: SLM3
locus tag: YDL033C
gene synonym: MTO2; MTU1
product: tRNA-5-taurinomethyluridine 2-sulfurtransferase
transcript id: NM_001180092.1
SIO_010081: YDL033C
subclass of: SO_0000673
so part of: YDL033C
location: complement(<392659..>393912)
location: region:392659-393912:-1
so has part: feature:392659-393912:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392659-393912:-1:exon

YDL033C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MTO2
alternative label: MTU1
gene: SLM3
locus tag: YDL033C
gene synonym: MTO2; MTU1
EC number: 2.8.1.14
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15944150|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0061708 tRNA-5-taurinomethyluridine 2-sulfurtransferase [PMID:15509579]
experiment: EXISTENCE:mutant phenotype:GO:1990799 mitochondrial tRNA wobble position uridine thiolation [PMID:15509579]
note: tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant
codon start: 1
product: tRNA-5-taurinomethyluridine 2-sulfurtransferase
translation: MLARYLNLIGRRSASPYRPQRLPAKFDNVIVAMSSGVDSSVAAALFAGEFPNTRGVYMQNWSESQSLDDPGKEPCYERDWRDVNRVAKHLNIRVDKVNFEQDYWIDVFEPMLRGYSEGSTPNPDIGCNKFVKFGKLREWLDEKYGTGNYWLVTGHYARVMQEMNGKGLFHLLRSIYRPKDQSYYLSQINSTVLSSLLLPIGHLTKPEVRDLAKYAGLPTAEKPDSQGICFVNNSQHGKFKNFLKHYLPSSPGDIITVDPQSGAKTTWGRHDGLWSYTIGQKVGISMPQADPNYQGTWFVSEKLRDTNEILIVRGRDNPALYSDTMRIENFSSLGPREDTINAFQNTGALTLQFRSLQVPVQIKSCKLNRSADNLDITIHLASKQRAITPGQSCCLYIDDRVLGSGPISHVNNNDTHA
SIO_010081: YDL033C
subclass of: SO_0000673
so part of: YDL033C
location: complement(392659..393912)
location: region:392659-393912:-1
so has part: feature:392659-393912:-1:exon

NP_010251.1
type: Protein
SIO_000068: ncbiprotein

S000002191
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392659-393912:-1:exon

YDL031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DBP10
locus tag: YDL031W
so part of: sequence
location: <394217..>397204
location: region:394217-397204:1
so has part: feature:394217-397204:1:exon
subclass of: SO_0000010

851530
type: Gene
SIO_000068: ncbigene

position:394217:1
position: 394217
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397204:1
position: 397204
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394217-397204:1:exon

YDL031W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DBP10
locus tag: YDL031W
product: putative ATP-dependent RNA helicase DBP10
transcript id: NM_001180090.2
SIO_010081: YDL031W
subclass of: SO_0000673
so part of: YDL031W
location: <394217..>397204
location: region:394217-397204:1
so has part: feature:394217-397204:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394217-397204:1:exon

YDL031W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DBP10
locus tag: YDL031W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10871363]
experiment: EXISTENCE:genetic interaction:GO:0030687 preribosome, large subunit precursor [PMID:16803892]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10871363]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10871363]
experiment: EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]
experiment: EXISTENCE:physical interaction:GO:0030687 preribosome, large subunit precursor [PMID:16095611|PMID:16803892]
note: Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
codon start: 1
product: putative ATP-dependent RNA helicase DBP10
translation: MAGVQKRKRDLEDQDDNGSEEDDIAFDIANEIALNDSESDANDSDSEVEADYGPNDVQDVIEYSSDEEEGVNNKKKAENKDIKKKKNSKKEIAAFPMLEMSDDENNASGKTQTGDDEDDVNEYFSTNNLEKTKHKKGSFPSFGLSKIVLNNIKRKGFRQPTPIQRKTIPLILQSRDIVGMARTGSGKTAAFILPMVEKLKSHSGKIGARAVILSPSRELAMQTFNVFKDFARGTELRSVLLTGGDSLEEQFGMMMTNPDVIIATPGRFLHLKVEMNLDLKSVEYVVFDEADRLFEMGFQEQLNELLASLPTTRQTLLFSATLPNSLVDFVKAGLVNPVLVRLDAETKVSENLEMLFLSSKNADREANLLYILQEIIKIPLATSEQLQKLQNSNNEADSDSDDENDRQKKRRNFKKEKFRKQKMPAANELPSEKATILFVPTRHHVEYISQLLRDCGYLISYIYGTLDQHARKRQLYNFRAGLTSILVVTDVAARGVDIPMLANVINYTLPGSSKIFVHRVGRTARAGNKGWAYSIVAENELPYLLDLELFLGKKILLTPMYDSLVDVMKKRWIDEGKPEYQFQPPKLSYTKRLVLGSCPRLDVEGLGDLYKNLMSSNFDLQLAKKTAMKAEKLYYRTRTSASPESLKRSKEIISSGWDAQNAFFGKNEEKEKLDFLAKLQNRRNKETVFEFTRNPDDEMAVFMKRRRKQLAPIQRKATERRELLEKERMAGLSHSIEDEILKGDDGETGYTVSEDALKEFEDADQLLEAQENENKKKKKPKSFKDPTFFLSHYAPAGDIQDKQLQITNGFANDAAQAAYDLNSDDKVQVHKQTATVKWDKKRKKYVNTQGIDNKKYIIGESGQKIAASFRSGRFDDWSKARNLKPLKVGSRETSIPSNLLEDPSQGPAANGRTVRGKFKHKQMKAPKMPDKHRDNYYSQKKKVEKALQSGISVKGYNNAPGLRSELKSTEQIRKDRIIAEKKRAKNARPSKKRKF
SIO_010081: YDL031W
subclass of: SO_0000673
so part of: YDL031W
location: 394217..397204
location: region:394217-397204:1
so has part: feature:394217-397204:1:exon

NP_010253.2
type: Protein
SIO_000068: ncbiprotein

S000002189
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394217-397204:1:exon

YDL030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRP9
locus tag: YDL030W
so part of: sequence
location: <397537..>399129
location: region:397537-399129:1
so has part: feature:397537-399129:1:exon
subclass of: SO_0000010

851531
type: Gene
SIO_000068: ncbigene

position:397537:1
position: 397537
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:399129:1
position: 399129
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397537-399129:1:exon

YDL030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRP9
locus tag: YDL030W
product: SF3a splicing factor complex subunit PRP9
transcript id: NM_001180089.1
SIO_010081: YDL030W
subclass of: SO_0000673
so part of: YDL030W
location: <397537..>399129
location: region:397537-399129:1
so has part: feature:397537-399129:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397537-399129:1:exon

YDL030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRP9
locus tag: YDL030W
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:8969185]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8065365]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:mutant phenotype:GO:0000395 mRNA 5'-splice site recognition [PMID:2147224]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:2147224]
note: Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
codon start: 1
product: SF3a splicing factor complex subunit PRP9
translation: MNLLETRRSLLEEMEIIENAIAERIQRNPELYYHYIQESSKVFPDTKLPRSSLIAENKIYKFKKVKRKRKQIILQQHEINIFLRDYQEKQQTFNKINRPEETQEDDKDLPNFERKLQQLEKELKNEDENFELDINSKKDKYALFSSSSDPSRRTNILSDRARDLDLNEIFTRDEQYGEYMELEQFHSLWLNVIKRGDCSLLQFLDILELFLDDEKYLLTPPMDRKNDRYMAFLLKLSKYVETFFFKSYALLDAAAVENLIKSDFEHSYCRGSLRSEAKGIYCPFCSRWFKTSSVFESHLVGKIHKKNESKRRNFVYSEYKLHRYLKYLNDEFSRTRSFVERKLAFTANERMAEMDILTQKYEAPAYDSTEKEGAEQVDGEQRDGQLQEEHLSGKSFDMPLGPDGLPMPYWLYKLHGLDREYRCEICSNKVYNGRRTFERHFNEERHIYHLRCLGIEPSSVFKGITKIKEAQELWKNMQGQSQLTSIAAVPPKPNPSQLKVPTELELEEEDEEGNVMSKKVYDELKKQGLV
SIO_010081: YDL030W
subclass of: SO_0000673
so part of: YDL030W
location: 397537..399129
location: region:397537-399129:1
so has part: feature:397537-399129:1:exon

NP_010254.1
type: Protein
SIO_000068: ncbiprotein

S000002188
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397537-399129:1:exon

YDL029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACT2
gene: ARP2
locus tag: YDL029W
gene synonym: ACT2
so part of: sequence
location: <399340..>400638
location: region:399340-400638:1
so has part: feature:399340-400638:1:exon
subclass of: SO_0000010

851532
type: Gene
SIO_000068: ncbigene

position:399340:1
position: 399340
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:400638:1
position: 400638
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:399340-400638:1:exon

YDL029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACT2
gene: ARP2
locus tag: YDL029W
gene synonym: ACT2
product: actin-related protein 2
transcript id: NM_001180088.1
SIO_010081: YDL029W
subclass of: SO_0000673
so part of: YDL029W
location: join(<399340..399361,399485..>400638)
location: region:399340-400638:1
so has part: feature:399340-399361:1:exon
so has part: feature:399485-400638:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:399340-399361:1:exon

position:399361:1
position: 399361
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:399485-400638:1:exon

position:399485:1
position: 399485
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDL029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACT2
gene: ARP2
locus tag: YDL029W
gene synonym: ACT2
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:15657399]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11248049]
experiment: EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:11248049]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:15657399]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16862144]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17118118]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:18287533]
experiment: EXISTENCE:mutant phenotype:GO:0034314 Arp2/3 complex-mediated actin nucleation [PMID:16862144]
experiment: EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]
experiment: EXISTENCE:mutant phenotype:GO:0051654 establishment of mitochondrion localization [PMID:16107558]
note: Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants
codon start: 1
product: actin-related protein 2
translation: MDPHNPIVLDQGTGFVKIGRAGENFPDYTFPSIVGRPILRAEERASVATPLKDIMIGDEASEVRSYLQISYPMENGIIKNWTDMELLWDYAFFEQMKLPSTSNGKILLTEPPMNPLKNREKMCEVMFEKYDFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLSHLTRRLDVAGRDVTRHLIDLLSRRGYAFNRTADFETVRQIKEKLCYVSYDLDLDTKLARETTALVESYELPDGRTIKVGQERFEAPECLFQPGLVDVEQPGVGELLFNTVQSADVDIRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWFSRVLHNDPSRLDKFKVRIEDPPRRKHMVFIGGAVLASIMADKDHMWLSKQEWQESGPSAMTKFGPR
SIO_010081: YDL029W
subclass of: SO_0000673
so part of: YDL029W
location: join(399340..399361,399485..400638)
location: region:399340-400638:1
so has part: feature:399340-399361:1:exon
so has part: feature:399485-400638:1:exon

NP_010255.1
type: Protein
SIO_000068: ncbiprotein

S000002187
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:399340-399361:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:399485-400638:1:exon

YDL028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAC8
alternative label: RPK1
gene: MPS1
locus tag: YDL028C
gene synonym: PAC8; RPK1
so part of: sequence
location: complement(<400997..>403291)
location: region:400997-403291:-1
so has part: feature:400997-403291:-1:exon
subclass of: SO_0000010

851533
type: Gene
SIO_000068: ncbigene

position:400997:-1
position: 400997
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:403291:-1
position: 403291
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:400997-403291:-1:exon

YDL028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAC8
alternative label: RPK1
gene: MPS1
locus tag: YDL028C
gene synonym: PAC8; RPK1
product: serine/threonine/tyrosine protein kinase MPS1
transcript id: NM_001180087.2
SIO_010081: YDL028C
subclass of: SO_0000673
so part of: YDL028C
location: complement(<400997..>403291)
location: region:400997-403291:-1
so has part: feature:400997-403291:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:400997-403291:-1:exon

YDL028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAC8
alternative label: RPK1
gene: MPS1
locus tag: YDL028C
gene synonym: PAC8; RPK1
EC number: 2.7.12.2
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11827982]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11278681|PMID:25382489]
experiment: EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:7737118]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:11827982]
experiment: EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:31405987]
experiment: EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:8567717]
experiment: EXISTENCE:genetic interaction:GO:0034501 protein localization to kinetochore [PMID:24402315]
experiment: EXISTENCE:mutant phenotype:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:15668173]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:8567717|PMID:32307893]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:1869587]
experiment: EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:18060784]
experiment: EXISTENCE:mutant phenotype:GO:0051225 spindle assembly [PMID:15668173]
experiment: EXISTENCE:mutant phenotype:GO:0051988 regulation of attachment of spindle microtubules to kinetochore [PMID:23334295]
note: Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); detected in peroxisomes; similar to human Mps1p
codon start: 1
product: serine/threonine/tyrosine protein kinase MPS1
translation: MSTNSFHDYVDLKSRTNTRQFSDDEEFTTPPKLSNFGSALLSHTEKTSASEILSSHNNDKIANRLEEMDRSSSRSHPPPSMGNLTSGHTSTSSHSTLFGRYLRNNHQTSMTTMNTSDIEINVGNSLDKSFERIRNLRQNMKEDITAKYAERRSKRFLISNRTTKLGPAKRAMTLTNIFDEDVPNSPNQPINARETVELPLEDSHQTNFKETKRNTDYDSIDFGDLNPIQYIKKHNLPTSDLPLISQIYFDKQREENRQAALRKHSSRELLYKSRSSSSSLSSNNLLANKDNSITSNNGSQPRRKVSTGSSSSKSSIEIRRALKENIDTSNNSNFNSPIHKIYKGISRNKDSDSEKREVLRNISINANHADNLLQQENKRLKRSLDDAITNENINSKNLEVFYHRPAPKPPVTKKVEIVEPAKSASLSNNRNIITVNDSQYEKIELLGRGGSSRVYKVKGSGNRVYALKRVSFDAFDDSSIDGFKGEIELLEKLKDQKRVIQLLDYEMGDGLLYLIMECGDHDLSQILNQRSGMPLDFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKGILKIIDFGIANAVPEHTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRLLAIMNPDVKIPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFLQPFMISGSIMEDLIRNAVRYGSEKPHISQDDLNDVVDTVLRKFADYKI
SIO_010081: YDL028C
subclass of: SO_0000673
so part of: YDL028C
location: complement(400997..403291)
location: region:400997-403291:-1
so has part: feature:400997-403291:-1:exon

NP_010256.2
type: Protein
SIO_000068: ncbiprotein

S000002186
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:400997-403291:-1:exon

YDL027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRX9
locus tag: YDL027C
so part of: sequence
location: complement(<403695..>404957)
location: region:403695-404957:-1
so has part: feature:403695-404957:-1:exon
subclass of: SO_0000010

851535
type: Gene
SIO_000068: ncbigene

position:403695:-1
position: 403695
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:404957:-1
position: 404957
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:403695-404957:-1:exon

YDL027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRX9
locus tag: YDL027C
product: Mrx9p
transcript id: NM_001180086.1
SIO_010081: YDL027C
subclass of: SO_0000673
so part of: YDL027C
location: complement(<403695..>404957)
location: region:403695-404957:-1
so has part: feature:403695-404957:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:403695-404957:-1:exon

YDL027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRX9
locus tag: YDL027C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:35779633]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Mitochondrial inner membrane protein; high copy suppressor of ER stress-mediated cell death; overexpression increases O2 consumption, impairs processing of COB and COX1 RNAs encoding mitochondrial oxidative phosphorylation factors, and impacts the transition from fermentative to respiratory metabolism
codon start: 1
product: Mrx9p
translation: MFKVPVGLASRTRELMNSVTLNSLNNGKGFNMYLPGILRAFPKPVPSAITSPAIPKYRGESFQFRKLSCISSNYCSTTHQFLSSLKSSTSRLVGKRAFHSSRRAEIKFIFSSKSPKNGNKPFVKVYKVSPFFIIFATASIFTFILTSTIVVIPLIFHFFFPLLIMFFFFKQFKKWQKNIFYKDVLTSLPKTKLKITLPTMRSLQLQPMVQSWKEISSRMGIPNEFAKGLNVDLVKQEETRKQFLSFLQKRVLESFTKNELGIRSYFLGDSVEKWIKESYDLELDIDNCRSELRKFQTFIFSSVRYKLYLDSMKNLPLNPSKKLEGKKHIADVYVIILDESFPAIMFNGGAYSKADFFKILQESETSNSSKTLNTIIAIKSVNTLLSKHFVITTNGDSGEFFSKYNISKINDKNTEYTLKE
SIO_010081: YDL027C
subclass of: SO_0000673
so part of: YDL027C
location: complement(403695..404957)
location: region:403695-404957:-1
so has part: feature:403695-404957:-1:exon

NP_010257.1
type: Protein
SIO_000068: ncbiprotein

S000002185
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:403695-404957:-1:exon

YDL025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTK1
locus tag: YDL025C
so part of: sequence
location: complement(<405344..>407206)
location: region:405344-407206:-1
so has part: feature:405344-407206:-1:exon
subclass of: SO_0000010

851536
type: Gene
SIO_000068: ncbigene

position:405344:-1
position: 405344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:407206:-1
position: 407206
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405344-407206:-1:exon

YDL025C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTK1
locus tag: YDL025C
product: putative serine/threonine protein kinase RTK1
transcript id: NM_001180084.1
SIO_010081: YDL025C
subclass of: SO_0000673
so part of: YDL025C
location: complement(<405344..>407206)
location: region:405344-407206:-1
so has part: feature:405344-407206:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:405344-407206:-1:exon

YDL025C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTK1
locus tag: YDL025C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23785265]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:23785265]
note: Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
codon start: 1
product: putative serine/threonine protein kinase RTK1
translation: MVKETPLHSSSSTSLSSLFRPTKLKNLSAKIFNGGGNQSYSKTDDVSRSSSRSSKKNTDSDQEDQIKYNKPNDRRSTIGKSPQGNGALSKESHVVASSTLTGISPTSAKKAPIDYSPSRPLPNNHNPVRTGHTVPHLPHSIHNPINYIHQGSKDAFHHPHPVRSTAHSNISTVSSAKSDTPSSNLSYQAHMHPVEILQKQIEDKHFMDSQASTPGSVELQHNSSSGSDDTSSRKKKSLRLTRFFKKIHNDYHDNHHHHHHHNRGSTPTKPKLNLNTNENIVESNGKALYETDNPVELLEKYGIPGRKLGEGASGSVSVVERTDGKLFACKMFRKPHLNNEGTNQSQLANYSKKVTTEFCIGSTLHHENIVETLDMLTEGDTYLLVMEYAPYDFFNLVMSNLMTQDEVNCYFKQLCHGVNYLHSMGLAHRDLKLDNCVVTKDGILKLIDFGSAVVFQYPYEDTIVKSHGIVGSDPYLAPELLKQTSYDPRVADVWSIAIIFYCMVLKRFPWKAPKKSFNSFRLFTEEPEDEDDIVRGPNKILRLLPRHSRTIIGRMLALEPKQRVLMNDVVKDDWLVSVPSCEVDPTSGDLVEKPKNHKHHLVTEEELNELTKQHGNKDSN
SIO_010081: YDL025C
subclass of: SO_0000673
so part of: YDL025C
location: complement(405344..407206)
location: region:405344-407206:-1
so has part: feature:405344-407206:-1:exon

NP_010259.1
type: Protein
SIO_000068: ncbiprotein

S000002183
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:405344-407206:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS414; Autonomously Replicating Sequence
so part of: sequence
location: 408075..408316
location: region:408075-408316:1
so has part: feature:408075-408316:1:region

S000118433
type: SGD
SIO_000068: sgd

position:408075:1
position: 408075
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:408316:1
position: 408316
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:408075-408316:1:region

YDL024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DIA3
locus tag: YDL024C
so part of: sequence
location: complement(<408451..>409857)
location: region:408451-409857:-1
so has part: feature:408451-409857:-1:exon
subclass of: SO_0000010

851537
type: Gene
SIO_000068: ncbigene

position:408451:-1
position: 408451
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:409857:-1
position: 409857
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:408451-409857:-1:exon

YDL024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DIA3
locus tag: YDL024C
product: putative acid phosphatase DIA3
transcript id: NM_001180083.1
SIO_010081: YDL024C
subclass of: SO_0000673
so part of: YDL024C
location: complement(<408451..>409857)
location: region:408451-409857:-1
so has part: feature:408451-409857:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:408451-409857:-1:exon

YDL024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DIA3
locus tag: YDL024C
EC number: 3.1.3.2
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:11063681]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11063681]
note: hypothetical protein; involved in invasive and pseudohyphal growth
codon start: 1
product: putative acid phosphatase DIA3
translation: MVKPVIFAICLGVLLSKALSIPLRSFADIELIGSQKSLFPFLGGSAPYFSFPANYGIPTDIPEGCRLTQVQMIGRHGERYPTRSEAKDIFEVWYKISNYTGKYEGSLSFLNNGYEFFIPDESLLEMETTLQNSIDVLNPYTGEMNAKRHAREFLAKYGKLMENCTNFPIFTTNSKRIYDTAQYFAEALGDGFNISLQTLSENSSSGANTLAAKSSCPNWNSNANNDILMSYSRDYLENISDRLNDENKGLNLSRKDAAALFSWCAFELNAKGYSNICDIFSAAELIHYSYETDLTSFYQNGPGYKLIKSIGANLFNATVKLIRQSAHLDQKVWLSFTHDTDILNYLTTAGLIDDTRNLTTNHVPFRDHSYHRSWYIPQGARVYTEKFQCSNDSYVRYVVNDAVVPIESCSSGPGFSCEEGTFYEYAKDRLRGVSFYEDCDVSKVSKEKELTFYWDWNTTRYNASLVNQ
SIO_010081: YDL024C
subclass of: SO_0000673
so part of: YDL024C
location: complement(408451..409857)
location: region:408451-409857:-1
so has part: feature:408451-409857:-1:exon

NP_010260.1
type: Protein
SIO_000068: ncbiprotein

S000002182
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:408451-409857:-1:exon

YDL022C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL022C-A
so part of: sequence
location: complement(<409808..>410056)
location: region:409808-410056:-1
so has part: feature:409808-410056:-1:exon
subclass of: SO_0000010

13393611
type: Gene
SIO_000068: ncbigene

position:409808:-1
position: 409808
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:410056:-1
position: 410056
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:409808-410056:-1:exon

YDL022C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL022C-A
product: uncharacterized protein
transcript id: NM_001270741.1
SIO_010081: YDL022C-A
subclass of: SO_0000673
so part of: YDL022C-A
location: complement(<409808..>410056)
location: region:409808-410056:-1
so has part: feature:409808-410056:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:409808-410056:-1:exon

YDL022C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL022C-A
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR; mRNA identified as translated by ribosome profiling data
codon start: 1
product: uncharacterized protein
translation: MYYLVPKTTYGNLQCSSLAMTFHERGESGDVLSCACRLYLYIMPLFFNTFLRQKYFQLCSNTPYRNNGEARYFCHLFRCSII
SIO_010081: YDL022C-A
subclass of: SO_0000673
so part of: YDL022C-A
location: complement(409808..410056)
location: region:409808-410056:-1
so has part: feature:409808-410056:-1:exon

NP_001257670.1
type: Protein
SIO_000068: ncbiprotein

S000028537
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:409808-410056:-1:exon

YNCD0004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0004W
so part of: sequence
location: 410379..410451
location: region:410379-410451:1
so has part: feature:410379-410451:1:exon
subclass of: SO_0000663

851538
type: Gene
SIO_000068: ncbigene

position:410379:1
position: 410379
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:410451:1
position: 410451
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410379-410451:1:exon

YNCD0004W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0004W
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCD0004W
subclass of: SO_0000673
so part of: YNCD0004W
location: 410379..410451
location: region:410379-410451:1
so has part: feature:410379-410451:1:exon

S000006510
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410379-410451:1:exon

YDL022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DAR1
alternative label: HOR1
alternative label: OSG1
alternative label: OSR5
gene: GPD1
locus tag: YDL022W
gene synonym: DAR1; HOR1; OSG1; OSR5
so part of: sequence
location: <411825..>413000
location: region:411825-413000:1
so has part: feature:411825-413000:1:exon
subclass of: SO_0000010

851539
type: Gene
SIO_000068: ncbigene

position:411825:1
position: 411825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:413000:1
position: 413000
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:411825-413000:1:exon

YDL022W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DAR1
alternative label: HOR1
alternative label: OSG1
alternative label: OSR5
gene: GPD1
locus tag: YDL022W
gene synonym: DAR1; HOR1; OSG1; OSR5
product: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
transcript id: NM_001180081.1
SIO_010081: YDL022W
subclass of: SO_0000673
so part of: YDL022W
location: <411825..>413000
location: region:411825-413000:1
so has part: feature:411825-413000:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:411825-413000:1:exon

YDL022W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DAR1
alternative label: HOR1
alternative label: OSG1
alternative label: OSR5
gene: GPD1
locus tag: YDL022W
gene synonym: DAR1; HOR1; OSG1; OSR5
EC number: 1.1.1.8
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20026609]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:15210723]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15210723]
experiment: EXISTENCE:mutant phenotype:GO:0006116 NADH oxidation [PMID:9171333]
experiment: EXISTENCE:mutant phenotype:GO:0006973 intracellular accumulation of glycerol [PMID:8196651]
experiment: EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:26276932]
experiment: EXISTENCE:mutant phenotype:GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [PMID:8196651]
note: NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import
codon start: 1
product: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
translation: MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED
SIO_010081: YDL022W
subclass of: SO_0000673
so part of: YDL022W
location: 411825..413000
location: region:411825-413000:1
so has part: feature:411825-413000:1:exon

NP_010262.1
type: Protein
SIO_000068: ncbiprotein

S000002180
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:411825-413000:1:exon

YDL021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPM2
locus tag: YDL021W
so part of: sequence
location: <413953..>414888
location: region:413953-414888:1
so has part: feature:413953-414888:1:exon
subclass of: SO_0000010

851541
type: Gene
SIO_000068: ncbigene

position:413953:1
position: 413953
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:414888:1
position: 414888
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413953-414888:1:exon

YDL021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPM2
locus tag: YDL021W
product: phosphoglycerate mutase family protein GPM2
transcript id: NM_001180080.1
SIO_010081: YDL021W
subclass of: SO_0000673
so part of: YDL021W
location: <413953..>414888
location: region:413953-414888:1
so has part: feature:413953-414888:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413953-414888:1:exon

YDL021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPM2
locus tag: YDL021W
EC number: 5.4.2.11
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24146988|PMID:11914276]
note: Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM2 has a paralog, GPM3, that arose from the whole genome duplication
codon start: 1
product: phosphoglycerate mutase family protein GPM2
translation: MTASTPSNVMTLFLLRHGQSELNHENIFCGWIDAKLTEKGKEQARHSAELIEQYCKANNLRLPQIGYTSRLIRTQQTIETMCEEFKLKPQLQVVYDFNKIKLGDEFGSDDKDNMKIPILQTWRLNERHYGSWQGQRKPNVLKEYGKDKYMFIRRDYEGKPPPVDLDREMIQQENEKGSSTGYEFKEPNRQIKYELECSNHDIVLPDSESLREVVYRLNPFLQNVILKLANQYDESSCLIVGHGSSVRSLLKILEGISDDDIKNVDIPNGIPLVVELDKNNGLKFIRKFYLDPESAKINAEKVRNEGFIKNP
SIO_010081: YDL021W
subclass of: SO_0000673
so part of: YDL021W
location: 413953..414888
location: region:413953-414888:1
so has part: feature:413953-414888:1:exon

NP_010263.1
type: Protein
SIO_000068: ncbiprotein

S000002179
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413953-414888:1:exon

YDL020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SON1
alternative label: UFD5
gene: RPN4
locus tag: YDL020C
gene synonym: SON1; UFD5
so part of: sequence
location: complement(<415113..>416708)
location: region:415113-416708:-1
so has part: feature:415113-416708:-1:exon
subclass of: SO_0000010

851542
type: Gene
SIO_000068: ncbigene

position:415113:-1
position: 415113
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416708:-1
position: 416708
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:415113-416708:-1:exon

YDL020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SON1
alternative label: UFD5
gene: RPN4
locus tag: YDL020C
gene synonym: SON1; UFD5
product: stress-regulated transcription factor RPN4
transcript id: NM_001180079.3
SIO_010081: YDL020C
subclass of: SO_0000673
so part of: YDL020C
location: complement(<415113..>416708)
location: region:415113-416708:-1
so has part: feature:415113-416708:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:415113-416708:-1:exon

YDL020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SON1
alternative label: UFD5
gene: RPN4
locus tag: YDL020C
gene synonym: SON1; UFD5
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10350051]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10350051]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19914394|PMID:8514125|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10350051|PMID:19914394]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15178333]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:20376190|PMID:11027285]
experiment: EXISTENCE:mutant phenotype:GO:0006282 regulation of DNA repair [PMID:11027285|PMID:20376190]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10350051|PMID:11248031|PMID:15178333|PMID:18804109|P MID:19914394|PMID:11027285|PMID:15575969|PMID:16556235|PMI D:18086556|PMID:18627600|PMID:27226598]
note: Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: stress-regulated transcription factor RPN4
translation: MASTELSLKRTLTDILEDELYHTNPGHSQFTSHYQNYHPNASITPYKLVNKNKENNTFTWNHSLQHQNESSAASIPPQQTYHFPIFNKYADPTLTTTTSFTTSEATANDRQINNVHLIPNEIKGASETPLQKTVNLKNIMKVSDPYVPTRNTFNYDVKISNDFFDNGDNLYGNDEEVLFYEDNYNPKMQWSLQDNSAAINNEDARAIFNNEFDSDDDDISDDEEDEIEENCLQQEQHQEEPLLSLDVTPISMFGSDQKTGRAKSSSHLFNEYSYVDSNMDSISSVVSEDLLDERGHEKIEDEDEDNDLDEDDIYDISLLKNRRKQSFVLNKNTIDFERFPSPSTSANVPSTATTGKRKPAKSSSNRSCVSNSNENGTLERIKKPTSAVVSSNASRRKLINYTKKHLSSHSSTNSNSKPSTASPSAHTSSSDGNNEIFTCQIMNLITNEPCGAQFSRSYDLTRHQNTIHAKRKIVFRCSECIKILGSEGYQKTFSRLDALTRHIKSKHEDLSLEQRQEVTKFAKANIGYVMG
SIO_010081: YDL020C
subclass of: SO_0000673
so part of: YDL020C
location: complement(415113..416708)
location: region:415113-416708:-1
so has part: feature:415113-416708:-1:exon

NP_010264.3
type: Protein
SIO_000068: ncbiprotein

S000002178
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:415113-416708:-1:exon

YDL019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OSH2
locus tag: YDL019C
so part of: sequence
location: complement(<417663..>421514)
location: region:417663-421514:-1
so has part: feature:417663-421514:-1:exon
subclass of: SO_0000010

851543
type: Gene
SIO_000068: ncbigene

position:417663:-1
position: 417663
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:421514:-1
position: 421514
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417663-421514:-1:exon

YDL019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OSH2
locus tag: YDL019C
product: oxysterol-binding protein related protein OSH2
transcript id: NM_001180078.1
SIO_010081: YDL019C
subclass of: SO_0000673
so part of: YDL019C
location: complement(<417663..>421514)
location: region:417663-421514:-1
so has part: feature:417663-421514:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417663-421514:-1:exon

YDL019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OSH2
locus tag: YDL019C
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:25420878]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12727870]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11408574|PMID:25420878]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11408574]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]
experiment: EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]
experiment: EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]
experiment: EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:24213531]
note: Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication
codon start: 1
product: oxysterol-binding protein related protein OSH2
translation: MSREDLSIAEDLNQVSKPLLKVKLLEVLGQGDFKHLKALVDNEFQPKDDPSVQQVLNLILHYAVQVAPILLIKEIVAHWVDQVGDEKSSSKSDDGIHLDLNYQDENGNTPLHLAAAQSRSDVISFLLSQKSINDCVKNKAHQQPLDMCKDLNVAQMIQLKRDDYFLETVHSLRAAMNKRDFSKLDSIWKNPRNLNLLDINGIDPETGTTLLYEYSQKKDIEMCQWLLKHGAEATVKDGKGRSPLDLVKNIKLPAKPSNNVTPEIKLKNLLEKNLREQAIVHEDVASSKPPTYKGFLKKWTNFAHGYKLRWFILSGDGNLSYYKDQSHVDRPRGTLKVSTCRLHIDSSEKLNFELLGGITGTTRWRLKGNHPIETTRWVNAIQSAIRFAKDKEILNKKKAVPPSLALKNKSPALISHSKTQGSLPEASQYYQHTLHKEVIQPSSVSLYRRPSNNLSVVSSEIQLNDNLTESGKRFVSKMIENRLDGSKTPVGVHTGSALQRVRSSNTLKSNRSMQSGSGVASPIDKVPNGANLSQSNTTTGSTASLSDNNYIDNFEGDEANSDDEEEDLGINFDRDEEYIKAQYGPYKEKLDMYEQAISIELSSLIELIEQEEPSPEVWLTIKKSLINTSTIFGKLKDLTYKRDKRLVDMVSKQGDVNNVWVQSVKELEMELSNKTERLASIDKERRGLKKILHKKLLESHATAGNKESLENDKEQESDTTASTLGQIAKFISATKEEDEASDADEFYDAAELVDEVTELTEAHPEISTAAAPKHAPPPVPNETDNDSQYVQDEKSKIESNVEKTSQKFEKQNNLVTEDEPKTDQSLKNFKAEDKESQVKEKTKEIASSVIGEKTIVAVTTVQKRKEEYLLKEGSYLGYEDGIRKRLSMDKDDRPKISLWAVLKSMVGKDMTRMTLPVTFNEPTSLLQRVAEDLEYSELLDQAATFEDSTLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQVSHHPPISATWTESPRWDFWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVIGILIGNPQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGEVYNKKKQKVWILGGHWNEAIFAKKVVKDGDLSLEKTRTAASAGNGPTDDGTKFLIWKANDRPEEPFNLTPFAITLNAPQPHLLPWLPPTDTRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAARRKREENNLEYHPQWFVRDTHPITKAKYWRYTGKYWVKRRDHDLKDCGDIF
SIO_010081: YDL019C
subclass of: SO_0000673
so part of: YDL019C
location: complement(417663..421514)
location: region:417663-421514:-1
so has part: feature:417663-421514:-1:exon

NP_010265.1
type: Protein
SIO_000068: ncbiprotein

S000002177
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417663-421514:-1:exon

YDL018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERP3
locus tag: YDL018C
so part of: sequence
location: complement(<422833..>423510)
location: region:422833-423510:-1
so has part: feature:422833-423510:-1:exon
subclass of: SO_0000010

851544
type: Gene
SIO_000068: ncbigene

position:422833:-1
position: 422833
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:423510:-1
position: 423510
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:422833-423510:-1:exon

YDL018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERP3
locus tag: YDL018C
product: Erp3p
transcript id: NM_001180077.1
SIO_010081: YDL018C
subclass of: SO_0000673
so part of: YDL018C
location: complement(<422833..>423510)
location: region:422833-423510:-1
so has part: feature:422833-423510:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:422833-423510:-1:exon

YDL018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERP3
locus tag: YDL018C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport
codon start: 1
product: Erp3p
translation: MSNLCVLFFQFFFLAQFFAEASPLTFELNKGRKECLYTLTPEIDCTISYYFAVQQGESNDFDVNYEIFAPDDKNKPIIERSGERQGEWSFIGQHKGEYAICFYGGKAHDKIVDLDFKYNCERQDDIRNERRKARKAQRNLRDSKTDPLQDSVENSIDTIERQLHVLERNIQYYKSRNTRNHHTVCSTEHRIVMFSIYGILLIIGMSCAQIAILEFIFRESRKHNV
SIO_010081: YDL018C
subclass of: SO_0000673
so part of: YDL018C
location: complement(422833..423510)
location: region:422833-423510:-1
so has part: feature:422833-423510:-1:exon

NP_010266.1
type: Protein
SIO_000068: ncbiprotein

S000002176
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:422833-423510:-1:exon

YDL017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LSD6
alternative label: SAS1
gene: CDC7
locus tag: YDL017W
gene synonym: LSD6; SAS1
so part of: sequence
location: <424209..>425732
location: region:424209-425732:1
so has part: feature:424209-425732:1:exon
subclass of: SO_0000010

851545
type: Gene
SIO_000068: ncbigene

position:424209:1
position: 424209
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:425732:1
position: 425732
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:424209-425732:1:exon

YDL017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LSD6
alternative label: SAS1
gene: CDC7
locus tag: YDL017W
gene synonym: LSD6; SAS1
product: serine/threonine protein kinase CDC7
transcript id: NM_001180076.3
SIO_010081: YDL017W
subclass of: SO_0000673
so part of: YDL017W
location: <424209..>425732
location: region:424209-425732:1
so has part: feature:424209-425732:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:424209-425732:1:exon

YDL017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LSD6
alternative label: SAS1
gene: CDC7
locus tag: YDL017W
gene synonym: LSD6; SAS1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10508166]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:23314252|PMID:34432494|PMID:10508166|PMID:10805723|P MID:18245450|PMID:19692334|PMID:9407029|PMID:25602519]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2023904]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:34432494]
experiment: EXISTENCE:direct assay:GO:0031431 Dbf4-dependent protein kinase complex [PMID:19692334]
experiment: EXISTENCE:direct assay:GO:1902977 mitotic DNA replication preinitiation complex assembly [PMID:21729781|PMID:26338774]
experiment: EXISTENCE:genetic interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]
experiment: EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:19013276]
experiment: EXISTENCE:genetic interaction:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:18372119]
experiment: EXISTENCE:genetic interaction:GO:0060903 positive regulation of meiosis I [PMID:18245451]
experiment: EXISTENCE:genetic interaction:GO:1904968 positive regulation of monopolar spindle attachment to meiosis I kinetochore [PMID:19013276]
experiment: EXISTENCE:genetic interaction:GO:1905263 positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:18245451|PMID:19013276]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:2023904|PMID:2166954|PMID:10508166|PMID:10805723|PMI D:18245450]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:9472018]
experiment: EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:16319063]
experiment: EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:19013276]
experiment: EXISTENCE:mutant phenotype:GO:1902977 mitotic DNA replication preinitiation complex assembly [PMID:21729781]
experiment: EXISTENCE:mutant phenotype:GO:1904968 positive regulation of monopolar spindle attachment to meiosis I kinetochore [PMID:19013276]
experiment: EXISTENCE:mutant phenotype:GO:1905263 positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:18245450]
experiment: EXISTENCE:mutant phenotype:GO:1905342 positive regulation of protein localization to kinetochore [PMID:34432494]
experiment: EXISTENCE:physical interaction:GO:0001100 negative regulation of exit from mitosis [PMID:19478884]
experiment: EXISTENCE:physical interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]
note: S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45 to drive assembly of the pre-IC and the CMG helicase; maintains Cse4p at kinetochores through phosphorylation to regulate chromosome segregation, regulates pre-meiotic replication, meiotic DSB formation, monopolar attachment of homologs during MI through monopolin recruitment and middle meiotic gene expression; HsCDC7 and DBF4 complement
codon start: 1
product: serine/threonine protein kinase CDC7
translation: MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEAQMDYKSMISSQNDYDNYANTNHDGGYSMRNHEQFCPCIMRNQYSPNSHNQTPPMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEASGLIWDKPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIEPQLPDPKTNMDAVDAYELKKYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELNENTYLLDGESTDEDDVVSSSEADLLDKDVLLISE
SIO_010081: YDL017W
subclass of: SO_0000673
so part of: YDL017W
location: 424209..425732
location: region:424209-425732:1
so has part: feature:424209-425732:1:exon

NP_010267.3
type: Protein
SIO_000068: ncbiprotein

S000002175
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:424209-425732:1:exon

YDL015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TSC13
locus tag: YDL015C
so part of: sequence
location: complement(<426002..>426934)
location: region:426002-426934:-1
so has part: feature:426002-426934:-1:exon
subclass of: SO_0000010

851547
type: Gene
SIO_000068: ncbigene

position:426002:-1
position: 426002
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426934:-1
position: 426934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:426002-426934:-1:exon

YDL015C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TSC13
locus tag: YDL015C
product: trans-2-enoyl-CoA reductase (NADPH) TSC13
transcript id: NM_001180074.1
SIO_010081: YDL015C
subclass of: SO_0000673
so part of: YDL015C
location: complement(<426002..>426934)
location: region:426002-426934:-1
so has part: feature:426002-426934:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:426002-426934:-1:exon

YDL015C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TSC13
locus tag: YDL015C
EC number: 1.3.1.93
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11113186]
experiment: EXISTENCE:mutant phenotype:GO:0000038 very long-chain fatty acid metabolic process [PMID:11113186]
experiment: EXISTENCE:mutant phenotype:GO:0016491 oxidoreductase activity [PMID:11113186]
note: Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant
codon start: 1
product: trans-2-enoyl-CoA reductase (NADPH) TSC13
translation: MPITIKSRSKGLRDTEIDLSKKPTLDDVLKKISANNHNISKYRIRLTYKKESKQVPVISESFFQEEADDSMEFFIKDLGPQISWRLVFFCEYLGPVLVHSLFYYLSTIPTVVDRWHSASSDYNPFLNRVAYFLILGHYGKRLFETLFVHQFSLATMPIFNLFKNCFHYWVLSGLISFGYFGYGFPFGNAKLFKYYSYLKLDDLSTLIGLFVLSELWNFYCHIKLRLWGDYQKKHGNAKIRVPLNQGIFNLFVAPNYTFEVWSWIWFTFVFKFNLFAVLFLTVSTAQMYAWAQKKNKKYHTRRAFLIPFVF
SIO_010081: YDL015C
subclass of: SO_0000673
so part of: YDL015C
location: complement(426002..426934)
location: region:426002-426934:-1
so has part: feature:426002-426934:-1:exon

NP_010269.1
type: Protein
SIO_000068: ncbiprotein

S000002173
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:426002-426934:-1:exon

YDL014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LOT3
gene: NOP1
locus tag: YDL014W
gene synonym: LOT3
so part of: sequence
location: <427364..>428347
location: region:427364-428347:1
so has part: feature:427364-428347:1:exon
subclass of: SO_0000010

851548
type: Gene
SIO_000068: ncbigene

position:427364:1
position: 427364
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:428347:1
position: 428347
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427364-428347:1:exon

YDL014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LOT3
gene: NOP1
locus tag: YDL014W
gene synonym: LOT3
product: rRNA methyltransferase NOP1
transcript id: NM_001180073.1
SIO_010081: YDL014W
subclass of: SO_0000673
so part of: YDL014W
location: <427364..>428347
location: region:427364-428347:1
so has part: feature:427364-428347:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:427364-428347:1:exon

YDL014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LOT3
gene: NOP1
locus tag: YDL014W
gene synonym: LOT3
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11932453|PMID:2686980]
experiment: EXISTENCE:direct assay:GO:0008649 rRNA methyltransferase activity [PMID:12215523]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:12215523]
experiment: EXISTENCE:direct assay:GO:0031428 box C/D RNP complex [PMID:11081632]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:1990258 histone glutamine methylation [PMID:24352239]
experiment: EXISTENCE:mutant phenotype:GO:0000494 box C/D RNA 3'-end processing [PMID:10733567|PMID:15167896]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:1825809]
experiment: EXISTENCE:mutant phenotype:GO:0008649 rRNA methyltransferase activity [PMID:12215523]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:12215523|PMID:8431947]
experiment: EXISTENCE:mutant phenotype:GO:0043144 sno(s)RNA processing [PMID:1825809]
experiment: EXISTENCE:mutant phenotype:GO:1990258 histone glutamine methylation [PMID:24352239]
experiment: EXISTENCE:mutant phenotype:GO:1990259 histone glutamine N-methyltransferase activity [PMID:24352239]
note: Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL
codon start: 1
product: rRNA methyltransferase NOP1
translation: MSFRPGSRGGSRGGSRGGFGGRGGSRGGARGGSRGGFGGRGGSRGGARGGSRGGFGGRGGSRGGARGGSRGGRGGAAGGARGGAKVVIEPHRHAGVYIARGKEDLLVTKNMAPGESVYGEKRISVEEPSKEDGVPPTKVEYRVWNPFRSKLAAGIMGGLDELFIAPGKKVLYLGAASGTSVSHVSDVVGPEGVVYAVEFSHRPGRELISMAKKRPNIIPIIEDARHPQKYRMLIGMVDCVFADVAQPDQARIIALNSHMFLKDQGGVVISIKANCIDSTVDAETVFAREVQKLREERIKPLEQLTLEPYERDHCIVVGRYMRSGLKK
SIO_010081: YDL014W
subclass of: SO_0000673
so part of: YDL014W
location: 427364..428347
location: region:427364-428347:1
so has part: feature:427364-428347:1:exon

NP_010270.1
type: Protein
SIO_000068: ncbiprotein

S000002172
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427364-428347:1:exon

YDL013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEX3
alternative label: ULS2
gene: SLX5
locus tag: YDL013W
gene synonym: HEX3; ULS2
so part of: sequence
location: <429067..>430926
location: region:429067-430926:1
so has part: feature:429067-430926:1:exon
subclass of: SO_0000010

851549
type: Gene
SIO_000068: ncbigene

position:429067:1
position: 429067
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:430926:1
position: 430926
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:429067-430926:1:exon

YDL013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEX3
alternative label: ULS2
gene: SLX5
locus tag: YDL013W
gene synonym: HEX3; ULS2
product: SUMO-targeted ubiquitin ligase complex subunit SLX5
transcript id: NM_001180072.3
SIO_010081: YDL013W
subclass of: SO_0000673
so part of: YDL013W
location: <429067..>430926
location: region:429067-430926:1
so has part: feature:429067-430926:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:429067-430926:1:exon

YDL013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEX3
alternative label: ULS2
gene: SLX5
locus tag: YDL013W
gene synonym: HEX3; ULS2
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23785440]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:17728242|PMID:17848550|PMID:18032921]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19270524|PMID:23785440]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:17728242|PMID:17848550|PMID:18032921|PMID:26906737]
experiment: EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:17848550]
experiment: EXISTENCE:direct assay:GO:0033768 SUMO-targeted ubiquitin ligase complex [PMID:17848550]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:11139495]
experiment: EXISTENCE:genetic interaction:GO:0016567 protein ubiquitination [PMID:26906737]
experiment: EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:16387868]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16428246]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:26960795]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:31320817]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:11139495|PMID:16325482]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:26906737]
experiment: EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:16387868]
experiment: EXISTENCE:physical interaction:GO:0032183 SUMO binding [PMID:17728242]
note: Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4
codon start: 1
product: SUMO-targeted ubiquitin ligase complex subunit SLX5
translation: MHSDTNGRTKSNNSPSDNNPNETVILIDSDKEEDASIREANLPVRLYPDRRVGRRRDALNRFVRSDSRSRNSQRTHITASSERPDFQANNDDITIIREVGRFFGDDGPIDPSAHYVDLDQEPGSETLETPRTIQVDNTNGYLNDNGNNNESDDGLTIVEERTTRPRVTLNLPGGERLEVTATTTDIPIRRSFEFQEDLGASRRQLLRRSATRARNLFVDRSDENDEDWTDDTHNLPEAIQRARRESRMRMSRRIAERQRRVQQQRVSSDENISTSIRLQSIRERIQSYTPDIRSAFHRAESLHEFRSILQNVAPITLQECEEELMALFTEFRNQLLQNWAIDRVRNTQEEALRLHREALERQERTAGRVFHRGTLRESITNYLNFNGEDGFLSRLWSGPALSDADEERHTQNIIDMIQEREERERDVVMKNLMNKTRAQQEEFEARAASLPEGYSASFDTTPKMKLDITKNGKEETIIVTDDDLAKTLEDIPVCCLCGAELGVGIPDDFTGISQKDRGVSFEGLVSKYKFHCPYQTLARPSMLDRDLSKRTFIASCGHAFCGRCFARIDNAKKKSKMPKKKLAQLKGSAHPDNYGPKLCPADSCKKLIRSRGRLKEVYF
SIO_010081: YDL013W
subclass of: SO_0000673
so part of: YDL013W
location: 429067..430926
location: region:429067-430926:1
so has part: feature:429067-430926:1:exon

NP_010271.3
type: Protein
SIO_000068: ncbiprotein

S000002171
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:429067-430926:1:exon

YDL012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL012C
so part of: sequence
location: complement(<431108..>431517)
location: region:431108-431517:-1
so has part: feature:431108-431517:-1:exon
subclass of: SO_0000010

851550
type: Gene
SIO_000068: ncbigene

position:431108:-1
position: 431108
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:431517:-1
position: 431517
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431108-431517:-1:exon

YDL012C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL012C
product: uncharacterized protein
transcript id: NM_001180071.1
SIO_010081: YDL012C
subclass of: SO_0000673
so part of: YDL012C
location: complement(join(<431108..431386,431473..>431517))
location: region:431108-431517:-1
so has part: feature:431473-431517:-1:exon
so has part: feature:431108-431386:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:431473-431517:-1:exon

position:431473:-1
position: 431473
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:431108-431386:-1:exon

position:431386:-1
position: 431386
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDL012C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL012C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12514182]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MSAQDYYGNSASKQSYSRPSAPPPGYETASRGYAPSQSQQNYYPPQQQQQQYQQQPQYYQQQQPQYYQQHPQQPIYVQQQPASSGNEDCLAGCLAGLCLCCTLDMLF
SIO_010081: YDL012C
subclass of: SO_0000673
so part of: YDL012C
location: complement(join(431108..431386,431473..431517))
location: region:431108-431517:-1
so has part: feature:431473-431517:-1:exon
so has part: feature:431108-431386:-1:exon

NP_010272.1
type: Protein
SIO_000068: ncbiprotein

S000002170
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:431473-431517:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:431108-431386:-1:exon

YDL010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GRX6
locus tag: YDL010W
so part of: sequence
location: <432330..>433025
location: region:432330-433025:1
so has part: feature:432330-433025:1:exon
subclass of: SO_0000010

851551
type: Gene
SIO_000068: ncbigene

position:432330:1
position: 432330
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433025:1
position: 433025
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:432330-433025:1:exon

YDL010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GRX6
locus tag: YDL010W
product: glutathione-disulfide reductase GRX6
transcript id: NM_001180069.1
SIO_010081: YDL010W
subclass of: SO_0000673
so part of: YDL010W
location: <432330..>433025
location: region:432330-433025:1
so has part: feature:432330-433025:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:432330-433025:1:exon

YDL010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GRX6
locus tag: YDL010W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:26928762|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:18400945]
experiment: EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:18503006]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:18503006]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:18503006]
experiment: EXISTENCE:direct assay:GO:0005796 Golgi lumen [PMID:18400945]
experiment: EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:18400945]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:18503006]
experiment: EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:18171082]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:18400945]
experiment: EXISTENCE:mutant phenotype:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:18400945]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18400945]
note: Cis-Golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
codon start: 1
product: glutathione-disulfide reductase GRX6
translation: MIPSNKRNARILSITTLLLLLVFFVAQNANFLTVEIKEETSKAFSTNMDNMAGGSSREYAAMPTSTTNKGSSEVDEEINEIKQKVGLQQPIASVDDSLSAIKNDKGSRITKAFNVQKEYSLILDLSPIIIFSKSTCSYSKGMKELLENEYQFIPNYYIIELDKHGHGEELQEYIKLVTGRGTVPNLLVNGVSRGGNEEIKKLHTQGKLLESLQVWSDGKFSVEQREKPSNN
SIO_010081: YDL010W
subclass of: SO_0000673
so part of: YDL010W
location: 432330..433025
location: region:432330-433025:1
so has part: feature:432330-433025:1:exon

NP_010274.1
type: Protein
SIO_000068: ncbiprotein

S000002168
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:432330-433025:1:exon

YDL009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL009C
so part of: sequence
location: complement(<432925..>433248)
location: region:432925-433248:-1
so has part: feature:432925-433248:-1:exon
subclass of: SO_0000010

851553
type: Gene
SIO_000068: ncbigene

position:432925:-1
position: 432925
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433248:-1
position: 433248
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:432925-433248:-1:exon

YDL009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL009C
product: uncharacterized protein
transcript id: NM_001270742.1
SIO_010081: YDL009C
subclass of: SO_0000673
so part of: YDL009C
location: complement(<432925..>433248)
location: region:432925-433248:-1
so has part: feature:432925-433248:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:432925-433248:-1:exon

YDL009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL009C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MKALSVLCFHNPFKRCLGQKSFFVGDSFFIPTPKRLVLGKLRLSNYTAFHDLIIHDLFIYIFILNFFFFPFCNNFNYWKVFHVAQPRIYHHSRLVMILKVSLECAVS
SIO_010081: YDL009C
subclass of: SO_0000673
so part of: YDL009C
location: complement(432925..433248)
location: region:432925-433248:-1
so has part: feature:432925-433248:-1:exon

NP_001257671.1
type: Protein
SIO_000068: ncbiprotein

S000002167
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:432925-433248:-1:exon

YDL008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APC11
locus tag: YDL008W
so part of: sequence
location: <433497..>433994
location: region:433497-433994:1
so has part: feature:433497-433994:1:exon
subclass of: SO_0000010

851554
type: Gene
SIO_000068: ncbigene

position:433497:1
position: 433497
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433994:1
position: 433994
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:433497-433994:1:exon

YDL008W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APC11
locus tag: YDL008W
product: anaphase promoting complex subunit 11
transcript id: NM_001180067.3
SIO_010081: YDL008W
subclass of: SO_0000673
so part of: YDL008W
location: <433497..>433994
location: region:433497-433994:1
so has part: feature:433497-433994:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:433497-433994:1:exon

YDL008W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APC11
locus tag: YDL008W
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:10888670]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]
note: Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
codon start: 1
product: anaphase promoting complex subunit 11
translation: MKVKINEVHSVFAWSWHIPSTSDEDAANNDPIGNDEDEDVCGICRASYNGTCPSCKFPGDQCPLVIGLCHHNFHDHCIYRWLDTPTSKGLCPMCRQTFQLQKGLAINDAHVQKFVEIVSRRREEMIEEGVAEEFVDFDEPIRQNTDNPIGRQQVDTILDEDFLLR
SIO_010081: YDL008W
subclass of: SO_0000673
so part of: YDL008W
location: 433497..433994
location: region:433497-433994:1
so has part: feature:433497-433994:1:exon

NP_010276.3
type: Protein
SIO_000068: ncbiprotein

S000002166
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:433497-433994:1:exon

YNCD0005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0005C
so part of: sequence
location: complement(434264..434336)
location: region:434264-434336:-1
so has part: feature:434264-434336:-1:exon
subclass of: SO_0000663

851555
type: Gene
SIO_000068: ncbigene

position:434264:-1
position: 434264
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:434336:-1
position: 434336
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434264-434336:-1:exon

YNCD0005C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0005C
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCD0005C
subclass of: SO_0000673
so part of: YNCD0005C
location: complement(434264..434336)
location: region:434264-434336:-1
so has part: feature:434264-434336:-1:exon

S000006739
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:434264-434336:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(434423..434739)
location: region:434423-434739:-1
so has part: feature:434423-434739:-1:region

S000006842
type: SGD
SIO_000068: sgd

position:434423:-1
position: 434423
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:434739:-1
position: 434739
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434423-434739:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS415; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 434971..435320
location: region:434971-435320:1
so has part: feature:434971-435320:1:region

S000130173
type: SGD
SIO_000068: sgd

position:434971:1
position: 434971
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:435320:1
position: 435320
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434971-435320:1:region

YDL007C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDL007C-A
so part of: sequence
location: complement(<436567..>436824)
location: region:436567-436824:-1
so has part: feature:436567-436824:-1:exon
subclass of: SO_0000010

3799969
type: Gene
SIO_000068: ncbigene

position:436567:-1
position: 436567
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:436824:-1
position: 436824
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:436567-436824:-1:exon

YDL007C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDL007C-A
product: uncharacterized protein
transcript id: NM_001184682.1
SIO_010081: YDL007C-A
subclass of: SO_0000673
so part of: YDL007C-A
location: complement(<436567..>436824)
location: region:436567-436824:-1
so has part: feature:436567-436824:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:436567-436824:-1:exon

YDL007C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDL007C-A
codon start: 1
product: uncharacterized protein
translation: MFLPIIFHTILTLLNFGKYYCLPIQEDDDKSGKEIEQILDNNIESLGLLLNSMSLSSNFTTGDPELDSLFQDDLIPELYSVLDGF
SIO_010081: YDL007C-A
subclass of: SO_0000673
so part of: YDL007C-A
location: complement(436567..436824)
location: region:436567-436824:-1
so has part: feature:436567-436824:-1:exon

NP_001032574.1
type: Protein
SIO_000068: ncbiprotein

S000113557
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:436567-436824:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 437149..437518
location: region:437149-437518:1
so has part: feature:437149-437518:1:region

S000006843
type: SGD
SIO_000068: sgd

position:437149:1
position: 437149
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:437518:1
position: 437518
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437149-437518:1:region

YNCD0006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0006W
so part of: sequence
location: 437772..437853
location: region:437772-437853:1
so has part: feature:437772-437853:1:exon
subclass of: SO_0000663

851556
type: Gene
SIO_000068: ncbigene

position:437772:1
position: 437772
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:437853:1
position: 437853
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437772-437853:1:exon

YNCD0006W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0006W
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCD0006W
subclass of: SO_0000673
so part of: YNCD0006W
location: 437772..437853
location: region:437772-437853:1
so has part: feature:437772-437853:1:exon

S000006721
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437772-437853:1:exon

YDL007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YHS4
alternative label: YTA5
gene: RPT2
locus tag: YDL007W
gene synonym: YHS4; YTA5
so part of: sequence
location: <438047..>439360
location: region:438047-439360:1
so has part: feature:438047-439360:1:exon
subclass of: SO_0000010

851557
type: Gene
SIO_000068: ncbigene

position:438047:1
position: 438047
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:439360:1
position: 439360
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438047-439360:1:exon

YDL007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YHS4
alternative label: YTA5
gene: RPT2
locus tag: YDL007W
gene synonym: YHS4; YTA5
product: proteasome regulatory particle base subunit RPT2
transcript id: NM_001180066.1
SIO_010081: YDL007W
subclass of: SO_0000673
so part of: YDL007W
location: <438047..>439360
location: region:438047-439360:1
so has part: feature:438047-439360:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:438047-439360:1:exon

YDL007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YHS4
alternative label: YTA5
gene: RPT2
locus tag: YDL007W
gene synonym: YHS4; YTA5
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15210724]
experiment: EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:7721833]
experiment: EXISTENCE:direct assay:GO:0045732 positive regulation of protein catabolic process [PMID:15135049]
experiment: EXISTENCE:genetic interaction:GO:0036402 proteasome-activating activity [PMID:11430818]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9724628]
experiment: EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:23102099]
experiment: EXISTENCE:mutant phenotype:GO:0036402 proteasome-activating activity [PMID:11430818]
experiment: EXISTENCE:mutant phenotype:GO:0043171 peptide catabolic process [PMID:9724628]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]
experiment: EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]
note: ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome
codon start: 1
product: proteasome regulatory particle base subunit RPT2
translation: MGQGVSSGQDKKKKKGSNQKPKYEPPVQSKFGRKKRKGGPATAEKLPNIYPSTRCKLKLLRMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNPLSIGTLEEIIDDDHAIVTSPTMPDYYVSILSFVDKELLEPGCSVLLHHKTMSIVGVLQDDADPMVSVMKMDKSPTESYSDIGGLESQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDLSTKKKILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRERRMQVTAEDFKQAKERVMKNKVEENLEGLYL
SIO_010081: YDL007W
subclass of: SO_0000673
so part of: YDL007W
location: 438047..439360
location: region:438047-439360:1
so has part: feature:438047-439360:1:exon

NP_010277.1
type: Protein
SIO_000068: ncbiprotein

S000002165
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:438047-439360:1:exon

YDL006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CWH47
alternative label: KCS2
alternative label: TPD1
gene: PTC1
locus tag: YDL006W
gene synonym: CWH47; KCS2; TPD1
so part of: sequence
location: <439909..>440754
location: region:439909-440754:1
so has part: feature:439909-440754:1:exon
subclass of: SO_0000010

851558
type: Gene
SIO_000068: ncbigene

position:439909:1
position: 439909
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440754:1
position: 440754
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:439909-440754:1:exon

YDL006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CWH47
alternative label: KCS2
alternative label: TPD1
gene: PTC1
locus tag: YDL006W
gene synonym: CWH47; KCS2; TPD1
product: type 2C protein phosphatase PTC1
transcript id: NM_001180065.3
SIO_010081: YDL006W
subclass of: SO_0000673
so part of: YDL006W
location: <439909..>440754
location: region:439909-440754:1
so has part: feature:439909-440754:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:439909-440754:1:exon

YDL006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CWH47
alternative label: KCS2
alternative label: TPD1
gene: PTC1
locus tag: YDL006W
gene synonym: CWH47; KCS2; TPD1
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:26546002|PMID:10580002]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11113180]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11113180]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:direct assay:GO:1990439 MAP kinase serine/threonine phosphatase activity [PMID:11113180]
experiment: EXISTENCE:genetic interaction:GO:0043409 negative regulation of MAPK cascade [PMID:26546002]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9529388]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:20400943]
experiment: EXISTENCE:mutant phenotype:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:8196609]
experiment: EXISTENCE:mutant phenotype:GO:0043409 negative regulation of MAPK cascade [PMID:26546002]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:14685261]
note: Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating the osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; involved in myosin-V dependent inheritance of mitochondria, peroxisomes, vacuoles and secretory vesicles; localizes to the nucleus, cytoplasm and peroxisomes
codon start: 1
product: type 2C protein phosphatase PTC1
translation: MSNHSEILERPETPYDITYRVGVAENKNSKFRRTMEDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWCGKHLHTIIEQNILADETRDVRDVLNDSFLAIDEEINTKLVGNSGCTAAVCVLRWELPDSVSDDSMDLAQHQRKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAVTRSLGDKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDITEPNEAAKVLVRYALENGTTDNVTVMVVFL
SIO_010081: YDL006W
subclass of: SO_0000673
so part of: YDL006W
location: 439909..440754
location: region:439909-440754:1
so has part: feature:439909-440754:1:exon

NP_010278.3
type: Protein
SIO_000068: ncbiprotein

S000002164
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:439909-440754:1:exon

YDL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MED2
locus tag: YDL005C
so part of: sequence
location: complement(<441014..>442309)
location: region:441014-442309:-1
so has part: feature:441014-442309:-1:exon
subclass of: SO_0000010

851559
type: Gene
SIO_000068: ncbigene

position:441014:-1
position: 441014
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442309:-1
position: 442309
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441014-442309:-1:exon

YDL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MED2
locus tag: YDL005C
product: Med2p
transcript id: NM_001180064.3
SIO_010081: YDL005C
subclass of: SO_0000673
so part of: YDL005C
location: complement(<441014..>442309)
location: region:441014-442309:-1
so has part: feature:441014-442309:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:441014-442309:-1:exon

YDL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MED2
locus tag: YDL005C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:9891034]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12468546]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15254252]
experiment: EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:33045248]
experiment: EXISTENCE:mutant phenotype:GO:0090399 replicative senescence [PMID:33045248]
experiment: EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11470794]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Med2p
translation: MVVQNSPVSSVHTANFSERGSNTRTMTYKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQQKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKEKEREEAEKKRAEQENMRKVREQEELKKRQELEEASQQQQLQQNSKEKNGLGLNFSTTAPANTTDANGSKENYQELGSLQSSSQTQLENANAANNGAAFSPLTTTRIQSQQAQPSDVMFNDLNSMDISMFSGLDSTGFDSTAFNATVDETKGFDDNDSGNNYNDINISSIENNINNNINSTKNGKDNNNESNKNNNGDEKNKNNNEDNENNNNSSEKNNNNNNNNNNNNDDNGNNNNNNSGNDNNNTTNNDSNNKNNSITTGNDNENIVNNDLPTTVVSNPGDNPPPADNGEEYLTLNDFNDLNIDWSTTGDNGELDLSGFNI
SIO_010081: YDL005C
subclass of: SO_0000673
so part of: YDL005C
location: complement(441014..442309)
location: region:441014-442309:-1
so has part: feature:441014-442309:-1:exon

NP_010279.3
type: Protein
SIO_000068: ncbiprotein

S000002163
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441014-442309:-1:exon

YDL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATP16
locus tag: YDL004W
so part of: sequence
location: <443029..>443511
location: region:443029-443511:1
so has part: feature:443029-443511:1:exon
subclass of: SO_0000010

851560
type: Gene
SIO_000068: ncbigene

position:443029:1
position: 443029
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:443511:1
position: 443511
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443029-443511:1:exon

YDL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATP16
locus tag: YDL004W
product: F1F0 ATP synthase subunit delta
transcript id: NM_001180063.1
SIO_010081: YDL004W
subclass of: SO_0000673
so part of: YDL004W
location: <443029..>443511
location: region:443029-443511:1
so has part: feature:443029-443511:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:443029-443511:1:exon

YDL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATP16
locus tag: YDL004W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk [PMID:17082766]
experiment: EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382]
experiment: EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]
experiment: EXISTENCE:mutant phenotype:GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk [PMID:8026496]
experiment: EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8026496]
experiment: EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:8026496]
note: Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated
codon start: 1
product: F1F0 ATP synthase subunit delta
translation: MLRSIIGKSASRSLNFVAKRSYAEAAAASSGLKLQFALPHETLYSGSEVTQVNLPAKSGRIGVLANHVPTVEQLLPGVVEVMEGSNSKKFFISGGFATVQPDSQLCVTAIEAFPLESFSQENIKNLLAEAKKNVSSSDAREAAEAAIQVEVLENLQSVLK
SIO_010081: YDL004W
subclass of: SO_0000673
so part of: YDL004W
location: 443029..443511
location: region:443029-443511:1
so has part: feature:443029-443511:1:exon

NP_010280.1
type: Protein
SIO_000068: ncbiprotein

S000002162
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443029-443511:1:exon

YDL003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PDS3
alternative label: RHC21
alternative label: SCC1
gene: MCD1
locus tag: YDL003W
gene synonym: PDS3; RHC21; SCC1
so part of: sequence
location: <444683..>446383
location: region:444683-446383:1
so has part: feature:444683-446383:1:exon
subclass of: SO_0000010

851561
type: Gene
SIO_000068: ncbigene

position:444683:1
position: 444683
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:446383:1
position: 446383
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:444683-446383:1:exon

YDL003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PDS3
alternative label: RHC21
alternative label: SCC1
gene: MCD1
locus tag: YDL003W
gene synonym: PDS3; RHC21; SCC1
product: kleisin alpha
transcript id: NM_001180062.1
SIO_010081: YDL003W
subclass of: SO_0000673
so part of: YDL003W
location: <444683..>446383
location: region:444683-446383:1
so has part: feature:444683-446383:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:444683-446383:1:exon

YDL003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PDS3
alternative label: RHC21
alternative label: SCC1
gene: MCD1
locus tag: YDL003W
gene synonym: PDS3; RHC21; SCC1
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:18614046]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18614046|PMID:9990856]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18321989]
experiment: EXISTENCE:direct assay:GO:0030892 mitotic cohesin complex [PMID:9990856]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:27325700]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11448778|PMID:23178808]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:18321989]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:18614046]
experiment: EXISTENCE:mutant phenotype:GO:0006979 response to oxidative stress [PMID:34897432]
experiment: EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:9335334]
experiment: EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:16962805]
experiment: EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:16888651]
experiment: EXISTENCE:physical interaction:GO:0019901 protein kinase binding [PMID:27325700]
note: Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
codon start: 1
product: kleisin alpha
translation: MVTENPQRLTVLRLATNKGPLAQIWLASNMSNIPRGSVIQTHIAESAKEIAKASGCDDESGDNEYITLRTSGELLQGIVRVYSKQATFLLTDIKDTLTKISMLFKTSQKMTSTVNRLNTVTRVHQLMLEDAVTEREVLVTPGLEFLDDTTIPVGLMAQENSMERKVQGAAPWDTSLEVGRRFSPDEDFEHNNLSSMNLDFDIEEGPITSKSWEEGTRQSSRNFDTHENYIQDDDFPLDDAGTIGWDLGITEKNDQNNDDDDNSVEQGRRLGESIMSEEPTDFGFDLDIEKEAPAGNIDTITDAMTESQPKQTGTRRNSKLLNTKSIQIDEETENSESIASSNTYKEERSNNLLTPQPTNFTTKRLWSEITESMSYLPDPILKNFLSYESLKKRKIHNGREGSIEEPELNVSLNLTDDVISNAGTNDNSFNELTDNMSDFVPIDAGLNEAPFPEENIIDAKTRNEQTTIQTEKVRPTPGEVASKAIVQMAKILRKELSEEKEVIFTDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPALFERFINA
SIO_010081: YDL003W
subclass of: SO_0000673
so part of: YDL003W
location: 444683..446383
location: region:444683-446383:1
so has part: feature:444683-446383:1:exon

NP_010281.1
type: Protein
SIO_000068: ncbiprotein

S000002161
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:444683-446383:1:exon

YDL002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HMO2
gene: NHP10
locus tag: YDL002C
gene synonym: HMO2
so part of: sequence
location: complement(<446967..>447578)
location: region:446967-447578:-1
so has part: feature:446967-447578:-1:exon
subclass of: SO_0000010

851562
type: Gene
SIO_000068: ncbigene

position:446967:-1
position: 446967
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:447578:-1
position: 447578
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:446967-447578:-1:exon

YDL002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HMO2
gene: NHP10
locus tag: YDL002C
gene synonym: HMO2
product: Nhp10p
transcript id: NM_001180061.3
SIO_010081: YDL002C
subclass of: SO_0000673
so part of: YDL002C
location: complement(<446967..>447578)
location: region:446967-447578:-1
so has part: feature:446967-447578:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:446967-447578:-1:exon

YDL002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HMO2
gene: NHP10
locus tag: YDL002C
gene synonym: HMO2
experiment: EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:19726587]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]
experiment: EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]
experiment: EXISTENCE:direct assay:GO:0045027 DNA end binding [PMID:19726587]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15607974]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17762868]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]
note: Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins
codon start: 1
product: Nhp10p
translation: MSVEEKKRRLEELKDQNVVLGLAIQRSRLSVKRLKLEYGVLLERLESRIELDPELNCEDPLPTLASFKQELLTKPFRKSKTKRHKVKERDPNMPKRPTNAYLLYCEMNKERIRQNGSLDVTRDLAEGWKNLNEQDRKPYYKLYSEDRERYQMEMEIYNKKISNIDADDDKEENEQKIKNNEEGSSTKVADSKGGEDGSLVSSN
SIO_010081: YDL002C
subclass of: SO_0000673
so part of: YDL002C
location: complement(446967..447578)
location: region:446967-447578:-1
so has part: feature:446967-447578:-1:exon

NP_010282.3
type: Protein
SIO_000068: ncbiprotein

S000002160
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:446967-447578:-1:exon

YDL001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RMD1
locus tag: YDL001W
so part of: sequence
location: <447984..>449276
location: region:447984-449276:1
so has part: feature:447984-449276:1:exon
subclass of: SO_0000010

851563
type: Gene
SIO_000068: ncbigene

position:447984:1
position: 447984
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:449276:1
position: 449276
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:447984-449276:1:exon

YDL001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RMD1
locus tag: YDL001W
product: Rmd1p
transcript id: NM_001180060.3
SIO_010081: YDL001W
subclass of: SO_0000673
so part of: YDL001W
location: <447984..>449276
location: region:447984-449276:1
so has part: feature:447984-449276:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:447984-449276:1:exon

YDL001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RMD1
locus tag: YDL001W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Cytoplasmic protein required for sporulation; targeted to vacuole via AP-3 pathway
codon start: 1
product: Rmd1p
translation: MVDSNDDQPERHALLHNDIQTSNNSRPSLVQKKYLPTPQDTRKSRASYTGSAMINPTSKQSRTGSGAQRTSRTAQKLKLLPEEPFQRDSERLTDLKNQEVYSQVNRIKDKPARRDAEKLGKAHRHLLPRSTAYCTASSYNMKELVRWLKDCRKLHHTHPKLFDECLYTPFIYNDWRGDKRFEDEDVIRLDDEGGEIIVSDKHPDLFIFEYGVVVMWGFTEREEKAFLNDIEKFEKEKLAEEDIQVEEFNYYVTKSYQPRIYNDFITLRDGSNYMVKLSISHAIAQSVKISLFEELVDNTIEDTQDIPQEIAYSGKVSMSKEDIMKSIGELFILRININLHGSVLDSPEIMWSEPQLEPIYQATRGYLEINQRVSLLNQRLEVISDLLQMLKEQLGHSHEEYLEFIVILLVGVEVLISVINIVVDMLASQH
SIO_010081: YDL001W
subclass of: SO_0000673
so part of: YDL001W
location: 447984..449276
location: region:447984-449276:1
so has part: feature:447984-449276:1:exon

NP_010283.3
type: Protein
SIO_000068: ncbiprotein

S000002159
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447984-449276:1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN4; Chromosome IV centromere
so part of: sequence
location: 449711..449821
location: region:449711-449821:1
so has part: feature:449711-449821:1:region

S000006466
type: SGD
SIO_000068: sgd

position:449711:1
position: 449711
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:449821:1
position: 449821
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449711-449821:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN4_CDEI of CEN4
so part of: sequence
location: 449711..449720
location: region:449711-449720:1
so has part: feature:449711-449720:1:region

position:449720:1
position: 449720
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449711-449720:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN4_CDEII of CEN4
so part of: sequence
location: 449721..449796
location: region:449721-449796:1
so has part: feature:449721-449796:1:region

position:449721:1
position: 449721
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:449796:1
position: 449796
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449721-449796:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN4_CDEIII of CEN4
so part of: sequence
location: 449797..449821
location: region:449797-449821:1
so has part: feature:449797-449821:1:region

position:449797:1
position: 449797
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449797-449821:1:region

YDR001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NTH1
locus tag: YDR001C
so part of: sequence
location: complement(<450220..>452475)
location: region:450220-452475:-1
so has part: feature:450220-452475:-1:exon
subclass of: SO_0000010

851564
type: Gene
SIO_000068: ncbigene

position:450220:-1
position: 450220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:452475:-1
position: 452475
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450220-452475:-1:exon

YDR001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NTH1
locus tag: YDR001C
product: alpha,alpha-trehalase NTH1
transcript id: NM_001180309.1
SIO_010081: YDR001C
subclass of: SO_0000673
so part of: YDR001C
location: complement(<450220..>452475)
location: region:450220-452475:-1
so has part: feature:450220-452475:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450220-452475:-1:exon

YDR001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NTH1
locus tag: YDR001C
EC number: 3.2.1.28
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0005993 trehalose catabolic process [PMID:23597844]
experiment: EXISTENCE:mutant phenotype:GO:0071465 cellular response to desiccation [PMID:25456447]
note: Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
codon start: 1
product: alpha,alpha-trehalase NTH1
translation: MSQVNTSQGPVAQGRQRRLSSLSEFNDPFSNAEVYYGPPTDPRKQKQAKPAKINRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQGNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYKHINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQFWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQASQMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLIGYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYGKILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASIKEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPYASKHGVTLDEFKQLYNDGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYEIDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESGFFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGGLAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRLAYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAATEGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
SIO_010081: YDR001C
subclass of: SO_0000673
so part of: YDR001C
location: complement(450220..452475)
location: region:450220-452475:-1
so has part: feature:450220-452475:-1:exon

NP_010284.1
type: Protein
SIO_000068: ncbiprotein

S000002408
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450220-452475:-1:exon

YDR002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CST20
alternative label: HTN1
alternative label: SFO1
alternative label: STP52
gene: YRB1
locus tag: YDR002W
gene synonym: CST20; HTN1; SFO1; STP52
so part of: sequence
location: <453045..>453650
location: region:453045-453650:1
so has part: feature:453045-453650:1:exon
subclass of: SO_0000010

851565
type: Gene
SIO_000068: ncbigene

position:453045:1
position: 453045
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:453650:1
position: 453650
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:453045-453650:1:exon

YDR002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CST20
alternative label: HTN1
alternative label: SFO1
alternative label: STP52
gene: YRB1
locus tag: YDR002W
gene synonym: CST20; HTN1; SFO1; STP52
product: Ran GTPase-binding protein YRB1
transcript id: NM_001180310.1
SIO_010081: YDR002W
subclass of: SO_0000673
so part of: YDR002W
location: <453045..>453650
location: region:453045-453650:1
so has part: feature:453045-453650:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:453045-453650:1:exon

YDR002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CST20
alternative label: HTN1
alternative label: SFO1
alternative label: STP52
gene: YRB1
locus tag: YDR002W
gene synonym: CST20; HTN1; SFO1; STP52
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10825193]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10825193]
experiment: EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:7836422]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10991951]
experiment: EXISTENCE:mutant phenotype:GO:0006405 RNA export from nucleus [PMID:7489726]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10991951]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7489726]
note: Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
codon start: 1
product: Ran GTPase-binding protein YRB1
translation: MSSEDKKPVVDKKEEAAPKPPSSAVFSMFGGKKAEKPETKKDEEDTKEETKKEGDDAPESPDIHFEPVVHLEKVDVKTMEEDEEVLYKVRAKLFRFDADAKEWKERGTGDCKFLKNKKTNKVRILMRRDKTLKICANHIIAPEYTLKPNVGSDRSWVYACTADIAEGEAEAFTFAIRFGSKENADKFKEEFEKAQEINKKA
SIO_010081: YDR002W
subclass of: SO_0000673
so part of: YDR002W
location: 453045..453650
location: region:453045-453650:1
so has part: feature:453045-453650:1:exon

NP_010285.1
type: Protein
SIO_000068: ncbiprotein

S000002409
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:453045-453650:1:exon

YDR003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSH5
gene: RCR2
locus tag: YDR003W
gene synonym: SSH5
so part of: sequence
location: <454122..>454754
location: region:454122-454754:1
so has part: feature:454122-454754:1:exon
subclass of: SO_0000010

851566
type: Gene
SIO_000068: ncbigene

position:454122:1
position: 454122
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:454754:1
position: 454754
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454122-454754:1:exon

YDR003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSH5
gene: RCR2
locus tag: YDR003W
gene synonym: SSH5
product: Rcr2p
transcript id: NM_001180311.3
SIO_010081: YDR003W
subclass of: SO_0000673
so part of: YDR003W
location: <454122..>454754
location: region:454122-454754:1
so has part: feature:454122-454754:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454122-454754:1:exon

YDR003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSH5
gene: RCR2
locus tag: YDR003W
gene synonym: SSH5
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17287526|PMID:14562095|PMID:32421152]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:32421152]
experiment: EXISTENCE:direct assay:GO:0031982 vesicle [PMID:17287526]
experiment: EXISTENCE:direct assay:GO:0072665 protein localization to vacuole [PMID:32421152]
experiment: EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17287526]
note: Vacuolar ubiquitin ligase-substrate adaptor; delivered to vacuole using ubiquitin as a sorting signal; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
codon start: 1
product: Rcr2p
translation: MILREQIDFLIHKRQDDNNNNGEAITDDDPFSSSSWRWGRWIFFIFFIVALLILLFSTAKVNRRRRIMGQAPIRGTAWLTPPTYRQSERDYNGTQRCVEDYVPEYTETANENDLGFYDERGEFHPNGKTEYLAPPPLSEEQASSTDKDLQRPVAAVVRIPSESEFDFNLLRPTMNNFVNGQSNRNEQHSPTVESSSFDVNNAPARAKVSK
SIO_010081: YDR003W
subclass of: SO_0000673
so part of: YDR003W
location: 454122..454754
location: region:454122-454754:1
so has part: feature:454122-454754:1:exon

NP_010286.3
type: Protein
SIO_000068: ncbiprotein

S000002410
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454122-454754:1:exon

YDR003W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR003W-A
so part of: sequence
location: <454782..>454904
location: region:454782-454904:1
so has part: feature:454782-454904:1:exon
subclass of: SO_0000010

1466432
type: Gene
SIO_000068: ncbigene

position:454782:1
position: 454782
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:454904:1
position: 454904
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454782-454904:1:exon

YDR003W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR003W-A
product: uncharacterized protein
transcript id: NM_001184646.3
SIO_010081: YDR003W-A
subclass of: SO_0000673
so part of: YDR003W-A
location: <454782..>454904
location: region:454782-454904:1
so has part: feature:454782-454904:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454782-454904:1:exon

YDR003W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR003W-A
note: hypothetical protein; identified by expression profiling and mass spectrometry
codon start: 1
product: uncharacterized protein
translation: MTCGIENSYKSAEKKKKYRSFRFFESRDYSELCIIVGTYY
SIO_010081: YDR003W-A
subclass of: SO_0000673
so part of: YDR003W-A
location: 454782..454904
location: region:454782-454904:1
so has part: feature:454782-454904:1:exon

NP_878061.3
type: Protein
SIO_000068: ncbiprotein

S000028819
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454782-454904:1:exon

YDR004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD57
locus tag: YDR004W
so part of: sequence
location: <455201..>456583
location: region:455201-456583:1
so has part: feature:455201-456583:1:exon
subclass of: SO_0000010

851567
type: Gene
SIO_000068: ncbigene

position:455201:1
position: 455201
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:456583:1
position: 456583
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455201-456583:1:exon

YDR004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD57
locus tag: YDR004W
product: putative DNA-dependent ATPase RAD57
transcript id: NM_001180312.1
SIO_010081: YDR004W
subclass of: SO_0000673
so part of: YDR004W
location: <455201..>456583
location: region:455201-456583:1
so has part: feature:455201-456583:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:455201-456583:1:exon

YDR004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD57
locus tag: YDR004W
experiment: EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:9159392]
experiment: EXISTENCE:direct assay:GO:0033065 Rad51C-XRCC3 complex [PMID:9159392]
experiment: EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:9679065]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]
experiment: EXISTENCE:physical interaction:GO:0000730 DNA recombinase assembly [PMID:11459983]
note: Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
codon start: 1
product: putative DNA-dependent ATPase RAD57
translation: MPRALSIKFDNTYMDLYDELPESKLLYDEEFSYLLDAVRQNGVCVVDFLTLTPKELARLIQRSINEVFRFQQLLVHEYNEKYLEICEKNSISPDNGPECFTTADVAMDELLGGGIFTHGITEIFGESSTGKSQLLMQLALSVQLSEPAGGLGGKCVYITTEGDLPTQRLESMLSSRPAYEKLGITQSNIFTVSCNDLINQEHIINVQLPILLERSKGSIKLVIIDSISHHLRVELQNKSFRESQENKNYLDRMAEKLQILAHDYSLSVVVANQVGDKPLANSPVAHRTYVTDYDYQLGWLVGWKNSTILYRQMNSLLGASSNNDEILSDDEDYMLIERVMSTVNDRNYDFFSKKKPPIIENKTVERNSSSPISRQSKKRKFDYRVPNLGLTWSNHVSTRILLQKSFKASTIIQRGEAHLYKGGDSASFWQVKRTMKVVYSTFAKPGQIAYQITKRGIETA
SIO_010081: YDR004W
subclass of: SO_0000673
so part of: YDR004W
location: 455201..456583
location: region:455201-456583:1
so has part: feature:455201-456583:1:exon

NP_010287.1
type: Protein
SIO_000068: ncbiprotein

S000002411
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455201-456583:1:exon

YDR005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAF1
locus tag: YDR005C
so part of: sequence
location: complement(<456836..>458103)
location: region:456836-458103:-1
so has part: feature:456836-458103:-1:exon
subclass of: SO_0000010

851568
type: Gene
SIO_000068: ncbigene

position:456836:-1
position: 456836
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:458103:-1
position: 458103
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:456836-458103:-1:exon

YDR005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAF1
locus tag: YDR005C
product: RNA polymerase III-inhibiting protein MAF1
transcript id: NM_001180313.1
SIO_010081: YDR005C
subclass of: SO_0000673
so part of: YDR005C
location: complement(join(<456836..458017,458098..>458103))
location: region:456836-458103:-1
so has part: feature:458098-458103:-1:exon
so has part: feature:456836-458017:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:458098-458103:-1:exon

position:458098:-1
position: 458098
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:456836-458017:-1:exon

position:458017:-1
position: 458017
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDR005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAF1
locus tag: YDR005C
experiment: EXISTENCE:direct assay:GO:0000994 RNA polymerase III core binding [PMID:16762835|PMID:20887893]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19574957|PMID:16762835|PMID:19684113]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19574957]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16762835|PMID:19574957|PMID:19684113]
experiment: EXISTENCE:direct assay:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:16762835]
experiment: EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:11438659]
experiment: EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:11438659|PMID:16762835]
experiment: EXISTENCE:physical interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:11438659|PMID:16762835]
note: Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions
codon start: 1
product: RNA polymerase III-inhibiting protein MAF1
translation: MKFIDELDIERVNQTLNFETNDCKIVGSCDIFTTKAVASDRKLYKTIDQHLDTILQENENYNATLQQQLAAPETNQSPCSSPFYSNRRDSNSFWEQKRRISFSEYNSNNNTNNSNGNSSNNNNYSGPNGSSPATFPKSAKLNDQNLKELVSNYDSGSMSSSSLDSSSKNDERIRRRSSSSISSFKSGKSSNNNYSSGTATNNVNKRRKSSINERPSNLSLGPFGPINEPSSRKIFAYLIAILNASYPDHDFSSVEPTDFVKTSLKTFISKFENTLYSLGRQPEEWVWEVINSHMTLSDCVLFQYSPSNSFLEDEPGYLWNLIGFLYNRKRKRVAYLYLICSRLNSSTGEVEDALAKKPQGKLIIDDGSNEYEGEYDFTYDENVIDDKSDQEESLQ
SIO_010081: YDR005C
subclass of: SO_0000673
so part of: YDR005C
location: complement(join(456836..458017,458098..458103))
location: region:456836-458103:-1
so has part: feature:458098-458103:-1:exon
so has part: feature:456836-458017:-1:exon

NP_010288.1
type: Protein
SIO_000068: ncbiprotein

S000002412
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:458098-458103:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:456836-458017:-1:exon

YDR006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOK1
locus tag: YDR006C
so part of: sequence
location: complement(<458542..>461247)
location: region:458542-461247:-1
so has part: feature:458542-461247:-1:exon
subclass of: SO_0000010

851569
type: Gene
SIO_000068: ncbigene

position:458542:-1
position: 458542
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461247:-1
position: 461247
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458542-461247:-1:exon

YDR006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOK1
locus tag: YDR006C
product: Sok1p
transcript id: NM_001180314.3
SIO_010081: YDR006C
subclass of: SO_0000673
so part of: YDR006C
location: complement(<458542..>461247)
location: region:458542-461247:-1
so has part: feature:458542-461247:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:458542-461247:-1:exon

YDR006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOK1
locus tag: YDR006C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8065298]
experiment: EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:8065298]
note: hypothetical protein; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
codon start: 1
product: Sok1p
translation: MDQPRTHSGPTTASNPAPSSTNSSSAPSATNSKQERSSSSLSKPSSVVPSKDSPDGDAIAKTQAAALKNDMKSGDTSTLDGSSQNIIPNRASMQKYIDQSSDLLSRSSGVITPSMSLNASTNATNNDSSGNSANSSDLKIPIDRDNTIFKTFDTKTGQFLKNDDNEEEIRRNNKVDSIPPKNIYTNINNPSPSPPPSSKQPPSASAPQLPPATEPHKEQAAQQQPPGNASNFLRIFSNKKMRSHSVPTILHSSLRKLSSHNQYYRNQNILLNHPTPSGISKKKFSRNHHQPYLHSNNPLSSNPLSLKRAIFLNQQISGNASTNANNDNINNSTATSMTNQSFLSSSNFDLTLEDRINYIKATPTPVPFPPINLQGLKEIDLQEILKNPQLRHDIIFDPLLQFRPNLDGERGNKKRQLANIYWNDVQNEIYVYSKRPEIFQYNRSRLVPLFDTLRDVLLTIVPQKESPMINNVLDTELNIQELLKGSLIMSNLSGWLADLFKHHCAPMRDPWVDKMSNKFKEAERDSSLTRLIEGLRLVFQILETMKLDIANHQIRILRPALLSNAVEFEKQYFNTLIASKRVNLNTSLLWFDKKFNENVTAGLVRNPSSITIPDVYNICIRSIINLLSCRKMVREYPTPLSFDHARLILLRADIRQIVCILVCRLLFQQLVANDPSMDKATKEYVIHTYSTKRLKNEIISIITDEHGNCRWTKNTMSIAVHLCKVIDDLHREYDNNGSCEQARRPQLPSLDNSKITFAKSWLSKQTQPLSEVYGVLENRVFKSLEDAIFNRSECTIDGRVKQDFVYLYNTNNGNVGSTNTLSTTTDTASVKISPSLMSPSKTSTTTPTGNAIASRGLFAATELEEFENVYRHLYALINLHWSVFGPHYIEMLGDKVNKKGI
SIO_010081: YDR006C
subclass of: SO_0000673
so part of: YDR006C
location: complement(458542..461247)
location: region:458542-461247:-1
so has part: feature:458542-461247:-1:exon

NP_010289.3
type: Protein
SIO_000068: ncbiprotein

S000002413
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:458542-461247:-1:exon

YDR007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRP1
locus tag: YDR007W
so part of: sequence
location: <461842..>462516
location: region:461842-462516:1
so has part: feature:461842-462516:1:exon
subclass of: SO_0000010

851570
type: Gene
SIO_000068: ncbigene

position:461842:1
position: 461842
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:462516:1
position: 462516
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:461842-462516:1:exon

YDR007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRP1
locus tag: YDR007W
product: phosphoribosylanthranilate isomerase TRP1
transcript id: NM_001180315.3
SIO_010081: YDR007W
subclass of: SO_0000673
so part of: YDR007W
location: <461842..>462516
location: region:461842-462516:1
so has part: feature:461842-462516:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:461842-462516:1:exon

YDR007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRP1
locus tag: YDR007W
EC number: 5.3.1.24
experiment: EXISTENCE:direct assay:GO:0000162 tryptophan biosynthetic process [PMID:3286643]
experiment: EXISTENCE:direct assay:GO:0004640 phosphoribosylanthranilate isomerase activity [PMID:3286643]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000162 tryptophan biosynthetic process [PMID:348687|PMID:10790693]
experiment: EXISTENCE:mutant phenotype:GO:0004640 phosphoribosylanthranilate isomerase activity [PMID:348687]
note: Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303
codon start: 1
product: phosphoribosylanthranilate isomerase TRP1
translation: MSVINFTGSSGPLVKVCGLQSTEAAECALDSDADLLGIICVPNRKRTIDPVIARKISSLVKAYKNSSGTPKYLVGVFRNQPKEDVLALVNDYGIDIVQLHGDESWQEYQEFLGLPVIKRLVFPKDCNILLSAASQKPHSFIPLFDSEAGGTGELLDWNSISDWVGRQESPESLHFMLAGGLTPENVGDALRLNGVIGVDVSGGVETNGVKDSNKIANFVKNAKK
SIO_010081: YDR007W
subclass of: SO_0000673
so part of: YDR007W
location: 461842..462516
location: region:461842-462516:1
so has part: feature:461842-462516:1:exon

NP_010290.3
type: Protein
SIO_000068: ncbiprotein

S000002414
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:461842-462516:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1; Early-firing autonomously replicating sequence; highly efficient chromosomal replicator active in nearly every cell cycle
so part of: sequence
location: 462567..462622
location: region:462567-462622:1
so has part: feature:462567-462622:1:region

S000029652
type: SGD
SIO_000068: sgd

position:462567:1
position: 462567
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:462622:1
position: 462622
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462567-462622:1:region

YDR009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAL3
locus tag: YDR009W
so part of: sequence
location: <463434..>464996
location: region:463434-464996:1
so has part: feature:463434-464996:1:exon
subclass of: SO_0000010

851572
type: Gene
SIO_000068: ncbigene

position:463434:1
position: 463434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:464996:1
position: 464996
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:463434-464996:1:exon

YDR009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAL3
locus tag: YDR009W
product: transcriptional regulator GAL3
transcript id: NM_001180317.1
SIO_010081: YDR009W
subclass of: SO_0000673
so part of: YDR009W
location: <463434..>464996
location: region:463434-464996:1
so has part: feature:463434-464996:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:463434-464996:1:exon

YDR009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAL3
locus tag: YDR009W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18952899]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10866670|PMID:18952899]
experiment: EXISTENCE:mutant phenotype:GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose [PMID:3013721]
experiment: EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:4577139]
experiment: EXISTENCE:mutant phenotype:GO:0045185 maintenance of protein location [PMID:19651897]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8628318]
note: Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication
codon start: 1
product: transcriptional regulator GAL3
translation: MNTNVPIFSSPVRDLPRSFEQKHLAVVDAFFQTYHVKPDFIARSPGRVNLIGEHIDYCDFSVLPLAIDVDMLCAVKILDEKNPSITLTNADPKFAQRKFDLPLDGSYMAIDPSVSEWSNYFKCGLHVAHSYLKKIAPERFNNTPLVGAQIFCQSDIPTGGGLSSAFTCAAALATIRANMGKNFDISKKDLTRITAVAEHYVGVNNGGMDQATSVYGEEDHALYVEFRPKLKATPFKFPQLKNHEISFVIANTLVKSNKFETAPTNYNLRVIEVTVAANALATRYSVALPSHKDNSNSERGNLRDFMDAYYARYENQAQPWNGDIGTGIERLLKMLQLVEESFSRKKSGFTVHEASTALNCSREEFTRDYLTTFPVRFQVLKLYQRAKHVYSESLRVLKALKMMTSATFHTDEDFFTDFGRLMNESQASCDKLYECSCIETNQICSIALANGSFGSRLTGAGWGGCTIHLVPSGANGNVEQVRKALIEKFYNVRYPDLTDEELKDAIIVSKPALGTCLYEQ
SIO_010081: YDR009W
subclass of: SO_0000673
so part of: YDR009W
location: 463434..464996
location: region:463434-464996:1
so has part: feature:463434-464996:1:exon

NP_010292.1
type: Protein
SIO_000068: ncbiprotein

S000002416
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:463434-464996:1:exon

YDR010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR010C
so part of: sequence
location: complement(<465051..>465383)
location: region:465051-465383:-1
so has part: feature:465051-465383:-1:exon
subclass of: SO_0000010

851573
type: Gene
SIO_000068: ncbigene

position:465051:-1
position: 465051
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:465383:-1
position: 465383
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465051-465383:-1:exon

YDR010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR010C
product: uncharacterized protein
transcript id: NM_001348808.1
SIO_010081: YDR010C
subclass of: SO_0000673
so part of: YDR010C
location: complement(<465051..>465383)
location: region:465051-465383:-1
so has part: feature:465051-465383:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:465051-465383:-1:exon

YDR010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR010C
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MCAEPDDWERIERHPRKLKIAPRMLDFYESYIVWREGNFFLCLRSFPNGVIRGGRCFFRATSLPWKNVYGYHGHITSVCGATLTRINRAMVASDAGMGSIGLTNLFLYRV
SIO_010081: YDR010C
subclass of: SO_0000673
so part of: YDR010C
location: complement(465051..465383)
location: region:465051-465383:-1
so has part: feature:465051-465383:-1:exon

NP_001335754.1
type: Protein
SIO_000068: ncbiprotein

S000002417
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465051-465383:-1:exon

YDR011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNQ2
locus tag: YDR011W
so part of: sequence
location: <465919..>470424
location: region:465919-470424:1
so has part: feature:465919-470424:1:exon
subclass of: SO_0000010

851574
type: Gene
SIO_000068: ncbigene

position:465919:1
position: 465919
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:470424:1
position: 470424
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465919-470424:1:exon

YDR011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNQ2
locus tag: YDR011W
product: ATP-binding cassette transporter SNQ2
transcript id: NM_001180319.1
SIO_010081: YDR011W
subclass of: SO_0000673
so part of: YDR011W
location: <465919..>470424
location: region:465919-470424:1
so has part: feature:465919-470424:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:465919-470424:1:exon

YDR011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNQ2
locus tag: YDR011W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030003 cellular cation homeostasis [PMID:8985171]
experiment: EXISTENCE:mutant phenotype:GO:0030003 cellular cation homeostasis [PMID:8985171]
note: Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
codon start: 1
product: ATP-binding cassette transporter SNQ2
translation: MSNIKSTQDSSHNAVARSSSASFAASEESFTGITHDKDEQSDTPADKLTKMLTGPARDTASQISATVSEMAPDVVSKVESFADALSRHTTRSGAFNMDSDSDDGFDAHAIFESFVRDADEQGIHIRKAGVTIEDVSAKGVDASALEGATFGNILCLPLTIFKGIKAKRHQKMRQIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGEVAYDGIPQEEMMKRYKADVIYNGELDVHFPYLTVKQTLDFAIACKTPALRVNNVSKKEYIASRRDLYATIFGLRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTALEYAKAIRIMTNLLKSTAFVTIYQASENIYETFDKVTVLYSGKQIYFGLIHEAKPYFAKMGYLCPPRQATAEFLTALTDPNGFHLIKPGYENKVPRTAEEFETYWLNSPEFAQMKKDIAAYKEKVNTEKTKEVYDESMAQEKSKYTRKKSYYTVSYWEQVKLCTQRGFQRIYGNKSYTVINVCSAIIQSFITGSLFYNTPSSTSGAFSRGGVLYFALLYYSLMGLANISFEHRPILQKHKGYSLYHPSAEAIGSTLASFPFRMIGLTCFFIILFFLSGLHRTAGSFFTIYLFLTMCSEAINGLFEMVSSVCDTLSQANSISGILMMSISMYSTYMIQLPSMHPWFKWISYVLPIRYAFESMLNAEFHGRHMDCANTLVPSGGDYDNLSDDYKVCAFVGSKPGQSYVLGDDYLKNQFQYVYKHTWRNFGILWCFLLGYVVLKVIFTEYKRPVKGGGDALIFKKGSKRFIAHADEESPDNVNDIDAKEQFSSESSGANDEVFDDLEAKGVFIWKDVCFTIPYEGGKRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQRNVGIITGDMLVNGRPIDASFERRTGYVQQQDIHIAELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAEALVGEVGCGLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILEAIGAGATASVKEDWHEKWLNSVEFEQTKEKVQDLINDLSKQETKSEVGDKPSKYATSYAYQFRYVLIRTSTSFWRSLNYIMSKMMLMLVGGLYIGFTFFNVGKSYVGLQNAMFAAFISIILSAPAMNQIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSELPYHLFFSTIFFVSSYFPLRIFFEASRSAVYFLNYCIMFQLYYVGLGLMILYMSPNLPSANVILGLCLSFMLSFCGVTQPVSLMPGFWTFMWKASPYTYFVQNLVGIMLHKKPVVCKKKELNYFNPPNGSTCGEYMKPFLEKATGYIENPDATSDCAYCIYEVGDNYLTHISSKYSYLWRNFGIFWIYIFFNIIAMVCVYYLFHVRQSSFLSPVSILNKIKNIRKKKQ
SIO_010081: YDR011W
subclass of: SO_0000673
so part of: YDR011W
location: 465919..470424
location: region:465919-470424:1
so has part: feature:465919-470424:1:exon

NP_010294.1
type: Protein
SIO_000068: ncbiprotein

S000002418
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465919-470424:1:exon

YDR012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL4B
locus tag: YDR012W
so part of: sequence
location: <471853..>472941
location: region:471853-472941:1
so has part: feature:471853-472941:1:exon
subclass of: SO_0000010

851575
type: Gene
SIO_000068: ncbigene

position:471853:1
position: 471853
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472941:1
position: 472941
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:471853-472941:1:exon

YDR012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL4B
locus tag: YDR012W
product: ribosomal 60S subunit protein L4B
transcript id: NM_001180320.3
SIO_010081: YDR012W
subclass of: SO_0000673
so part of: YDR012W
location: <471853..>472941
location: region:471853-472941:1
so has part: feature:471853-472941:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:471853-472941:1:exon

YDR012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL4B
locus tag: YDR012W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
note: Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog, RPL4A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L4B
translation: MSRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQTSAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRYATASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLKVLKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAPGAHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIRPAGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFAETLKHD
SIO_010081: YDR012W
subclass of: SO_0000673
so part of: YDR012W
location: 471853..472941
location: region:471853-472941:1
so has part: feature:471853-472941:1:exon

NP_010295.3
type: Protein
SIO_000068: ncbiprotein

S000002419
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:471853-472941:1:exon

YDR013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDC101
gene: PSF1
locus tag: YDR013W
gene synonym: CDC101
so part of: sequence
location: <473157..>473783
location: region:473157-473783:1
so has part: feature:473157-473783:1:exon
subclass of: SO_0000010

851576
type: Gene
SIO_000068: ncbigene

position:473157:1
position: 473157
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:473783:1
position: 473783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:473157-473783:1:exon

YDR013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDC101
gene: PSF1
locus tag: YDR013W
gene synonym: CDC101
product: DNA replication protein PSF1
transcript id: NM_001180321.3
SIO_010081: YDR013W
subclass of: SO_0000673
so part of: YDR013W
location: <473157..>473783
location: region:473157-473783:1
so has part: feature:473157-473783:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:473157-473783:1:exon

YDR013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDC101
gene: PSF1
locus tag: YDR013W
gene synonym: CDC101
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]
experiment: EXISTENCE:genetic interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12768207|PMID:12730134]
experiment: EXISTENCE:mutant phenotype:GO:0031261 DNA replication preinitiation complex [PMID:12730134]
experiment: EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12768207|PMID:12730134]
note: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
codon start: 1
product: DNA replication protein PSF1
translation: MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQLGMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDTNNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI
SIO_010081: YDR013W
subclass of: SO_0000673
so part of: YDR013W
location: 473157..473783
location: region:473157-473783:1
so has part: feature:473157-473783:1:exon

NP_010296.3
type: Protein
SIO_000068: ncbiprotein

S000002420
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:473157-473783:1:exon

YDR014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: WPL1
gene: RAD61
locus tag: YDR014W
gene synonym: WPL1
so part of: sequence
location: <474046..>475989
location: region:474046-475989:1
so has part: feature:474046-475989:1:exon
subclass of: SO_0000010

851577
type: Gene
SIO_000068: ncbigene

position:474046:1
position: 474046
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:475989:1
position: 475989
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:474046-475989:1:exon

YDR014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: WPL1
gene: RAD61
locus tag: YDR014W
gene synonym: WPL1
product: Rad61p
transcript id: NM_001180322.1
SIO_010081: YDR014W
subclass of: SO_0000673
so part of: YDR014W
location: <474046..>475989
location: region:474046-475989:1
so has part: feature:474046-475989:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:474046-475989:1:exon

YDR014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: WPL1
gene: RAD61
locus tag: YDR014W
gene synonym: WPL1
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:18653893]
experiment: EXISTENCE:genetic interaction:GO:0034183 negative regulation of maintenance of mitotic sister chromatid cohesion [PMID:22901742]
experiment: EXISTENCE:mutant phenotype:GO:0034183 negative regulation of maintenance of mitotic sister chromatid cohesion [PMID:22901742|PMID:23219725]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:31617566]
experiment: EXISTENCE:mutant phenotype:GO:0140588 chromatin looping [PMID:32032532]
experiment: EXISTENCE:mutant phenotype:GO:1902340 negative regulation of chromosome condensation [PMID:23219725]
note: Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin
codon start: 1
product: Rad61p
translation: MRAYGKRGPVLRTPFRSNKGLPSSSDVEFSDDDVNSVIPDVSSTISSSIADHPIEGLLDEPRKAQDSSSSFDGANEKPSSQLDSKRNDQNVKIITSSDTSMAFMKDEKLSAFNFLDGSKASKRKRRRTYQKHDANITSSIEPDVQDEDSITMHNEFESIRKIYNDINEFILKLPRADDDILNKMLENEMKMDDSIENNSIRTSKDKKYGKFRTILINKNKENEIMGEEVDQKANTLSLNNADNSNAEKEGLTSTNHYNELKNMGDTIKYQDDIEFLLSNSKSNDNTTVPINEYFKKLLNLSLMIINDEEFFQYAKRYFKKEIIKLSFAQFRSDFPELILLQGYLLHKVSESQSDFPPSFDNFSIELSKDDGKIRTKKNKHIKKLSHLNFEDFLRKTQFKTGLYYSLSLWEMHGNLSLDIIKRISILASNKDLFSRHVKTFIPLLEKLITASEFCHMYIEQPEMFDSLISNLNNQFKDMLDDDSLIKILILLTNMEVHNYTLWKEADMIFQSSMNTILESIHPLTDAKVDNILLHLGLCLNICSRENSRLKLDGKLWYDMKTIFVKMIRDGSDTENRLVQGLFYLNFSFLIKQRKENSNLDPGELNLLLVELEAFKSETSQFNEGISNKIEIALNYLKSIYTSERITI
SIO_010081: YDR014W
subclass of: SO_0000673
so part of: YDR014W
location: 474046..475989
location: region:474046-475989:1
so has part: feature:474046-475989:1:exon

NP_010297.1
type: Protein
SIO_000068: ncbiprotein

S000002421
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:474046-475989:1:exon

YDR014W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HED1
locus tag: YDR014W-A
so part of: sequence
location: <477797..>478285
location: region:477797-478285:1
so has part: feature:477797-478285:1:exon
subclass of: SO_0000010

4036073
type: Gene
SIO_000068: ncbigene

position:477797:1
position: 477797
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478285:1
position: 478285
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:477797-478285:1:exon

YDR014W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HED1
locus tag: YDR014W-A
product: Hed1p
transcript id: NM_001184688.1
SIO_010081: YDR014W-A
subclass of: SO_0000673
so part of: YDR014W-A
location: <477797..>478285
location: region:477797-478285:1
so has part: feature:477797-478285:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:477797-478285:1:exon

YDR014W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HED1
locus tag: YDR014W-A
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16818607]
experiment: EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:18347097]
experiment: EXISTENCE:direct assay:GO:0045950 negative regulation of mitotic recombination [PMID:16818607]
experiment: EXISTENCE:direct assay:GO:1903873 negative regulation of DNA recombinase mediator complex assembly [PMID:18347097]
experiment: EXISTENCE:genetic interaction:GO:0007130 synaptonemal complex assembly [PMID:24367271]
experiment: EXISTENCE:genetic interaction:GO:0045950 negative regulation of mitotic recombination [PMID:16818607]
experiment: EXISTENCE:mutant phenotype:GO:0004857 enzyme inhibitor activity [PMID:27483004]
experiment: EXISTENCE:mutant phenotype:GO:0045950 negative regulation of mitotic recombination [PMID:16818607]
note: Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; promotes synapsis and required for the normal morphogenesis of synaptonemal complex; prevents the recruitment of Rad54p to site-specific DNA double-strand breaks in vivo; early meiotic gene, transcribed specifically during meiotic prophase
codon start: 1
product: Hed1p
translation: MQQRSNRRSCSYIPLGVHNNAEKSLCTEVAPARKNKRSITTSPIVNINVVERRLFNLELEKQQLRAKNLSENTGGGSPNGGAYLDAKKGVREQDQYQGGPSKELDRLQPPPSMKKSPPRKKKSLKDLIYETNKTFYQVDSNKVKYKVGLSKKQLLPSKTVDN
SIO_010081: YDR014W-A
subclass of: SO_0000673
so part of: YDR014W-A
location: 477797..478285
location: region:477797-478285:1
so has part: feature:477797-478285:1:exon

NP_001035220.1
type: Protein
SIO_000068: ncbiprotein

S000113613
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:477797-478285:1:exon

YDR016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DAD1
locus tag: YDR016C
so part of: sequence
location: complement(<478474..>478758)
location: region:478474-478758:-1
so has part: feature:478474-478758:-1:exon
subclass of: SO_0000010

851579
type: Gene
SIO_000068: ncbigene

position:478474:-1
position: 478474
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478758:-1
position: 478758
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:478474-478758:-1:exon

YDR016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DAD1
locus tag: YDR016C
product: Dad1p
transcript id: NM_001180324.3
SIO_010081: YDR016C
subclass of: SO_0000673
so part of: YDR016C
location: complement(<478474..>478758)
location: region:478474-478758:-1
so has part: feature:478474-478758:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:478474-478758:-1:exon

YDR016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DAD1
locus tag: YDR016C
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]
experiment: EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]
experiment: EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]
note: Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
codon start: 1
product: Dad1p
translation: MMASTSNDEEKLISTTDKYFIEQRNIVLQEINETMNSILNGLNGLNISLESSIAVGREFQSVSDLWKTLYDGLESLSDEAPIDEQPTLSQSKTK
SIO_010081: YDR016C
subclass of: SO_0000673
so part of: YDR016C
location: complement(478474..478758)
location: region:478474-478758:-1
so has part: feature:478474-478758:-1:exon

NP_010299.3
type: Protein
SIO_000068: ncbiprotein

S000002423
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:478474-478758:-1:exon

YDR017C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KCS1
locus tag: YDR017C
so part of: sequence
location: complement(<479115..>482267)
location: region:479115-482267:-1
so has part: feature:479115-482267:-1:exon
subclass of: SO_0000010

851580
type: Gene
SIO_000068: ncbigene

position:479115:-1
position: 479115
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:482267:-1
position: 482267
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:479115-482267:-1:exon

YDR017C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KCS1
locus tag: YDR017C
product: inositol polyphosphate kinase KCS1
transcript id: NM_001180325.3
SIO_010081: YDR017C
subclass of: SO_0000673
so part of: YDR017C
location: complement(<479115..>482267)
location: region:479115-482267:-1
so has part: feature:479115-482267:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:479115-482267:-1:exon

YDR017C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KCS1
locus tag: YDR017C
EC number: 2.7.4.21
experiment: EXISTENCE:direct assay:GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity [PMID:10827188]
experiment: EXISTENCE:direct assay:GO:0000828 inositol hexakisphosphate kinase activity [PMID:10574768|PMID:11956213]
experiment: EXISTENCE:direct assay:GO:0000829 inositol heptakisphosphate kinase activity [PMID:11956213]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032958 inositol phosphate biosynthetic process [PMID:10574768|PMID:17412958]
experiment: EXISTENCE:mutant phenotype:GO:0010919 regulation of inositol phosphate biosynthetic process [PMID:23824185]
experiment: EXISTENCE:mutant phenotype:GO:0032958 inositol phosphate biosynthetic process [PMID:11956213]
note: Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7
codon start: 1
product: inositol polyphosphate kinase KCS1
translation: MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD
SIO_010081: YDR017C
subclass of: SO_0000673
so part of: YDR017C
location: complement(479115..482267)
location: region:479115-482267:-1
so has part: feature:479115-482267:-1:exon

NP_010300.3
type: Protein
SIO_000068: ncbiprotein

S000002424
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:479115-482267:-1:exon

YDR018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR018C
so part of: sequence
location: complement(<482670..>483860)
location: region:482670-483860:-1
so has part: feature:482670-483860:-1:exon
subclass of: SO_0000010

851581
type: Gene
SIO_000068: ncbigene

position:482670:-1
position: 482670
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483860:-1
position: 483860
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482670-483860:-1:exon

YDR018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR018C
product: putative acyltransferase
transcript id: NM_001180326.1
SIO_010081: YDR018C
subclass of: SO_0000673
so part of: YDR018C
location: complement(<482670..>483860)
location: region:482670-483860:-1
so has part: feature:482670-483860:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482670-483860:-1:exon

YDR018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR018C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
codon start: 1
product: putative acyltransferase
translation: MKHSQKYRRYGIYEKTGNPFIKGLQRLLIACLFISGSLSIVVFQICLQVLLPWSKIRFQNGINQSKKAFIVLLCMILNMVAPSSLNVTFETSRPLKNSSNAKPCFRFKDRAIIIANHQMYADWIYLWWLSFVSNLGGNVYIILKKALQYIPLLGFGMRNFKFIFLSRNWQKDEKALTNSLVSMDLNARCKGPLTNYKSCYSKTNESIAAYNLIMFPEGTNLSLKTREKSEAFCQRAHLDHVQLRHLLLPHSKGLKFAVEKLAPSLDAIYDVTIGYSPALRTEYVGTKFTLKKIFLMGVYPEKVDFYIREFRVNEIPLQDDEVFFNWLLGVWKEKDQLLEDYYNTGQFKSNAKNDNQSIVVTTQTTGFQHETLTPRILSYYGFFAFLILVFVMKKNH
SIO_010081: YDR018C
subclass of: SO_0000673
so part of: YDR018C
location: complement(482670..483860)
location: region:482670-483860:-1
so has part: feature:482670-483860:-1:exon

NP_010301.1
type: Protein
SIO_000068: ncbiprotein

S000002425
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482670-483860:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS417; Autonomously Replicating Sequence
so part of: sequence
location: 484006..484059
location: region:484006-484059:1
so has part: feature:484006-484059:1:region

S000118434
type: SGD
SIO_000068: sgd

position:484006:1
position: 484006
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:484059:1
position: 484059
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484006-484059:1:region

YDR019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GSD1
gene: GCV1
locus tag: YDR019C
gene synonym: GSD1
so part of: sequence
location: complement(<484163..>485365)
location: region:484163-485365:-1
so has part: feature:484163-485365:-1:exon
subclass of: SO_0000010

851582
type: Gene
SIO_000068: ncbigene

position:484163:-1
position: 484163
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:485365:-1
position: 485365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484163-485365:-1:exon

YDR019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GSD1
gene: GCV1
locus tag: YDR019C
gene synonym: GSD1
product: glycine decarboxylase subunit T
transcript id: NM_001180327.1
SIO_010081: YDR019C
subclass of: SO_0000673
so part of: YDR019C
location: complement(<484163..>485365)
location: region:484163-485365:-1
so has part: feature:484163-485365:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:484163-485365:-1:exon

YDR019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GSD1
gene: GCV1
locus tag: YDR019C
gene synonym: GSD1
EC number: 2.1.2.10
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0006730 one-carbon metabolic process [PMID:10871621]
experiment: EXISTENCE:mutant phenotype:GO:0004375 glycine dehydrogenase (decarboxylating) activity [PMID:9047339]
experiment: EXISTENCE:mutant phenotype:GO:0005960 glycine cleavage complex [PMID:9047339]
experiment: EXISTENCE:mutant phenotype:GO:0006544 glycine metabolic process [PMID:9047339]
experiment: EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:10871621]
note: T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
codon start: 1
product: glycine decarboxylase subunit T
translation: MSIIKKIVFKRFNSTLKKTALHDLHVSLGGTMVPYAGYSMPVLYKGQTHIESHNWTRTNAGLFDVSHMLQSKLSGPHSVKFLQRVTPTDFNALPVGSGTLSVLLNPQGGVVDDTIITKENDDNEFYIVTNAGCAERDTEFFHDELQNGSTLDCQWKIIEGRSLLALQGPKAKDVLEPLLSKTAPGKDLKELFFGQRHEFALKDGSLVQIARGGYTGEDGFEISIANEKAVEFAEQLLANPVMKPIGLAARDSLRLEAGMCLYGHELDESITPVEAALNWVISKSRRDLVDQKYWFNGYAKIMDQLNNKTYSKVRVGFKYLKKGPAARNGVKIFLPDAETEVGLVTSGSASPTLNNINIGQAYVQKGYHKKGTKLLVQVRNKFYPIELAKMPLVPTHYYKQ
SIO_010081: YDR019C
subclass of: SO_0000673
so part of: YDR019C
location: complement(484163..485365)
location: region:484163-485365:-1
so has part: feature:484163-485365:-1:exon

NP_010302.1
type: Protein
SIO_000068: ncbiprotein

S000002426
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:484163-485365:-1:exon

YDR020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RRT3
gene: DAS2
locus tag: YDR020C
gene synonym: RRT3
so part of: sequence
location: complement(<485746..>486444)
location: region:485746-486444:-1
so has part: feature:485746-486444:-1:exon
subclass of: SO_0000010

851583
type: Gene
SIO_000068: ncbigene

position:485746:-1
position: 485746
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:486444:-1
position: 486444
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485746-486444:-1:exon

YDR020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RRT3
gene: DAS2
locus tag: YDR020C
gene synonym: RRT3
product: putative uridine kinase DAS2
transcript id: NM_001180328.3
SIO_010081: YDR020C
subclass of: SO_0000673
so part of: YDR020C
location: complement(<485746..>486444)
location: region:485746-486444:-1
so has part: feature:485746-486444:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485746-486444:-1:exon

YDR020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RRT3
gene: DAS2
locus tag: YDR020C
gene synonym: RRT3
EC number: 2.7.1.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
codon start: 1
product: putative uridine kinase DAS2
translation: MDRKAVEEKRIVISIGGGHATGVGAIALDLQNTFKSLYNSINIRVINLDNMIEGNIKSYNNNDYDFDNILNLVYEKHAVTSQNDMIQHDYEDPIDLIIVCGCYALYDKRINEISQLKVFLDSDADKRLISLIKKKNVGSNEQLAQLITEYMDHLRPEMQQYIEPTRTFADLIIPSTNENLGRAVLVDGIVKAIEDTKSQIEGNNTNNKIRPRLWDFEAETMDLEKDRYYDLS
SIO_010081: YDR020C
subclass of: SO_0000673
so part of: YDR020C
location: complement(485746..486444)
location: region:485746-486444:-1
so has part: feature:485746-486444:-1:exon

NP_010303.3
type: Protein
SIO_000068: ncbiprotein

S000002427
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485746-486444:-1:exon

YDR021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAL1
locus tag: YDR021W
so part of: sequence
location: <486804..>488003
location: region:486804-488003:1
so has part: feature:486804-488003:1:exon
subclass of: SO_0000010

851584
type: Gene
SIO_000068: ncbigene

position:486804:1
position: 486804
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:488003:1
position: 488003
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:486804-488003:1:exon

YDR021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAL1
locus tag: YDR021W
product: ATP-dependent RNA helicase FAL1
transcript id: NM_001180329.3
SIO_010081: YDR021W
subclass of: SO_0000673
so part of: YDR021W
location: <486804..>488003
location: region:486804-488003:1
so has part: feature:486804-488003:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:486804-488003:1:exon

YDR021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAL1
locus tag: YDR021W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9372960]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:15167894]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]
experiment: EXISTENCE:physical interaction:GO:0097078 FAL1-SGD1 complex [PMID:21576267]
note: Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3
codon start: 1
product: ATP-dependent RNA helicase FAL1
translation: MSFDREEDQKLKFKTSKKLKVSSTFESMNLKDDLLRGIYSYGFEAPSSIQSRAITQIISGKDVIAQAQSGTGKTATFTIGLLQAIDLRKKDLQALILSPTRELASQIGQVVKNLGDYMNVNAFAITGGKTLKDDLKKMQKHGCQAVSGTPGRVLDMIKKQMLQTRNVQMLVLDEADELLSETLGFKQQIYDIFAKLPKNCQVVVVSATMNKDILEVTRKFMNDPVKILVKRDEISLEGIKQYVVNVDKEEWKFDTLCDIYDSLTITQCVIFCNTKKKVDWLSQRLIQSNFAVVSMHGDMKQEERDKVMNDFRTGHSRVLISTDVWARGIDVQQVSLVINYDLPEIIENYIHRIGRSGRFGRKGVAINFITKADLAKLREIEKFYSIKINPMPANFAELS
SIO_010081: YDR021W
subclass of: SO_0000673
so part of: YDR021W
location: 486804..488003
location: region:486804-488003:1
so has part: feature:486804-488003:1:exon

NP_010304.3
type: Protein
SIO_000068: ncbiprotein

S000002428
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:486804-488003:1:exon

YDR022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CIS1
gene: ATG31
locus tag: YDR022C
gene synonym: CIS1
so part of: sequence
location: complement(<488072..>488662)
location: region:488072-488662:-1
so has part: feature:488072-488662:-1:exon
subclass of: SO_0000010

851585
type: Gene
SIO_000068: ncbigene

position:488072:-1
position: 488072
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:488662:-1
position: 488662
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488072-488662:-1:exon

YDR022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CIS1
gene: ATG31
locus tag: YDR022C
gene synonym: CIS1
product: Atg31p
transcript id: NM_001180330.1
SIO_010081: YDR022C
subclass of: SO_0000673
so part of: YDR022C
location: complement(<488072..>488662)
location: region:488072-488662:-1
so has part: feature:488072-488662:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:488072-488662:-1:exon

YDR022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CIS1
gene: ATG31
locus tag: YDR022C
gene synonym: CIS1
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:17362880|PMID:18497569]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:17362880]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
note: Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion
codon start: 1
product: Atg31p
translation: MNVTVTVYDKNVKYRLEENIKNNKGPSNDDQPAYNNESKSTDGSDYAMFPTNIKYIFEDNNDELVDSSDAALTAGIDKVGDELENVIIVQLDESGSLEDITLISDQYELLSHRTNSLSLEENQMRTLSSHGDDKSNDEEEELSVDSDRFRVDSDIELDVISQFCDLSPFLRDLSLNDLIKLYVTQNEQLQMLSNSV
SIO_010081: YDR022C
subclass of: SO_0000673
so part of: YDR022C
location: complement(488072..488662)
location: region:488072-488662:-1
so has part: feature:488072-488662:-1:exon

NP_010305.1
type: Protein
SIO_000068: ncbiprotein

S000002429
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488072-488662:-1:exon

YNCD0007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0007C
so part of: sequence
location: complement(488797..488870)
location: region:488797-488870:-1
so has part: feature:488797-488870:-1:exon
subclass of: SO_0000663

851586
type: Gene
SIO_000068: ncbigene

position:488797:-1
position: 488797
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:488870:-1
position: 488870
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488797-488870:-1:exon

YNCD0007C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0007C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCD0007C
subclass of: SO_0000673
so part of: YNCD0007C
location: complement(488797..488870)
location: region:488797-488870:-1
so has part: feature:488797-488870:-1:exon

S000006770
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488797-488870:-1:exon

YDR023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SES1
locus tag: YDR023W
so part of: sequence
location: <489508..>490896
location: region:489508-490896:1
so has part: feature:489508-490896:1:exon
subclass of: SO_0000010

851587
type: Gene
SIO_000068: ncbigene

position:489508:1
position: 489508
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490896:1
position: 490896
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:489508-490896:1:exon

YDR023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SES1
locus tag: YDR023W
product: serine--tRNA ligase SES1
transcript id: NM_001180331.1
SIO_010081: YDR023W
subclass of: SO_0000673
so part of: YDR023W
location: <489508..>490896
location: region:489508-490896:1
so has part: feature:489508-490896:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:489508-490896:1:exon

YDR023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SES1
locus tag: YDR023W
EC number: 6.1.1.11
experiment: EXISTENCE:direct assay:GO:0004828 serine-tRNA ligase activity [PMID:3031581]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006434 seryl-tRNA aminoacylation [PMID:3031581]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
note: Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
codon start: 1
product: serine--tRNA ligase SES1
translation: MLDINQFIEDKGGNPELIRQSQKARNASVEIVDEIISDYKDWVKTRFELDELNKKFNKLQKDIGLKFKNKEDASGLLAEKEKLTQQKKELTEKEQQEDKDLKKKVFQVGNIVHPSVVVSNDEENNELVRTWKPEDLEAVGPIASVTGKPASLSHHEILLRLDGYDPDRGVKICGHRGYFFRNYGVFLNQALINYGLQFLAAKGYIPLQAPVMMNKELMSKTAQLSEFDEELYKVIDGEDEKYLIATSEQPISAYHSGEWFEKPQEQLPIHYVGYSSCFRREAGSHGKDAWGVFRVHAFEKIEQFVITEPEKSWEEFEKMISYSEEFYKSLKLPYRIVGIVSGELNNAAAKKYDLEAWFPYQKEYKELVSCSNCTDYQSRNLEIRCGIKKMGDREKKYVHCLNSTLAATQRALCCILENYQTEDGLVVPEVLRKYIPGEPEFLPFVNELPKNSTSSKDKKKKN
SIO_010081: YDR023W
subclass of: SO_0000673
so part of: YDR023W
location: 489508..490896
location: region:489508-490896:1
so has part: feature:489508-490896:1:exon

NP_010306.1
type: Protein
SIO_000068: ncbiprotein

S000002430
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:489508-490896:1:exon

YDR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS11A
locus tag: YDR025W
so part of: sequence
location: <491515..>492324
location: region:491515-492324:1
so has part: feature:491515-492324:1:exon
subclass of: SO_0000010

851589
type: Gene
SIO_000068: ncbigene

position:491515:1
position: 491515
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:492324:1
position: 492324
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491515-492324:1:exon

YDR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS11A
locus tag: YDR025W
product: ribosomal 40S subunit protein S11A
transcript id: NM_001180333.3
SIO_010081: YDR025W
subclass of: SO_0000673
so part of: YDR025W
location: join(<491515..491559,491899..>492324)
location: region:491515-492324:1
so has part: feature:491515-491559:1:exon
so has part: feature:491899-492324:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491515-491559:1:exon

position:491559:1
position: 491559
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:491899-492324:1:exon

position:491899:1
position: 491899
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS11A
locus tag: YDR025W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8070651]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S11A
translation: MSTELTVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAGKANKQFAKF
SIO_010081: YDR025W
subclass of: SO_0000673
so part of: YDR025W
location: join(491515..491559,491899..492324)
location: region:491515-492324:1
so has part: feature:491515-491559:1:exon
so has part: feature:491899-492324:1:exon

NP_010308.3
type: Protein
SIO_000068: ncbiprotein

S000002432
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491515-491559:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:491899-492324:1:exon

YDR026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YTT1
gene: NSI1
locus tag: YDR026C
gene synonym: YTT1
so part of: sequence
location: complement(<492556..>494268)
location: region:492556-494268:-1
so has part: feature:492556-494268:-1:exon
subclass of: SO_0000010

851590
type: Gene
SIO_000068: ncbigene

position:492556:-1
position: 492556
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:494268:-1
position: 494268
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492556-494268:-1:exon

YDR026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YTT1
gene: NSI1
locus tag: YDR026C
gene synonym: YTT1
product: Nsi1p
transcript id: NM_001180334.3
SIO_010081: YDR026C
subclass of: SO_0000673
so part of: YDR026C
location: complement(<492556..>494268)
location: region:492556-494268:-1
so has part: feature:492556-494268:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:492556-494268:-1:exon

YDR026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YTT1
gene: NSI1
locus tag: YDR026C
gene synonym: YTT1
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:25092870]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006363 termination of RNA polymerase I transcription [PMID:22805593]
experiment: EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:22362748]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:22362748]
experiment: EXISTENCE:mutant phenotype:GO:0006363 termination of RNA polymerase I transcription [PMID:22805593]
note: RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
codon start: 1
product: Nsi1p
translation: MDSVSNLKSTNFQNNNDPKESVEEAVLRYVGVDLKNHIKKTKKKLKKQKKRKHGSKMSHEDEDTDMDWYLKTSGSKDLRKVDDIEPNSVAVAAVAAAYNSSMREKDKRSCHKKSSNSRSERKKHRKRKSSKERKAKIKMVLDPQLTTLDDGITTTAFLPDDLIAETAFDKYVDTEKAYLAKHPSKSLEVNEDDKENNFNNNSSTLVRIYTDLEGIPNDGSYIKRTPKIPEKDVKSDDLILAPEENNGDTALLRSDIVKASVIDGAITKSIGKKFTPSEENALDQFIEEYMKIRGLDRRQMCERIWSTDGVIRDGFWANISKVLPYRTRSSIYKHIRRKYHIFEQRGKWTPEEDQELARLCLEKEGHWTEVGKLLGRMPEDCRDRWRNYMKCGSKRGSKRWSKEEEELLTTVVNEMIEEAHQYQRMKALEAANKNDRYNQMYSRGPKGKRISDNPTFKDMINWTVVSERMSGTRSRIQCRYKWNKLVTDEAARSMLSIPVSERKWLLERLKQLPKTSYSNIDWNSIATYKPGYPRTGLELRLCYEQMREKIHDFKGRSTAEIIDSLLEQIN
SIO_010081: YDR026C
subclass of: SO_0000673
so part of: YDR026C
location: complement(492556..494268)
location: region:492556-494268:-1
so has part: feature:492556-494268:-1:exon

NP_010309.3
type: Protein
SIO_000068: ncbiprotein

S000002433
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:492556-494268:-1:exon

YDR027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CGP1
alternative label: LUV1
alternative label: TCS3
gene: VPS54
locus tag: YDR027C
gene synonym: CGP1; LUV1; TCS3
so part of: sequence
location: complement(<494649..>497318)
location: region:494649-497318:-1
so has part: feature:494649-497318:-1:exon
subclass of: SO_0000010

851591
type: Gene
SIO_000068: ncbigene

position:494649:-1
position: 494649
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:497318:-1
position: 497318
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:494649-497318:-1:exon

YDR027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CGP1
alternative label: LUV1
alternative label: TCS3
gene: VPS54
locus tag: YDR027C
gene synonym: CGP1; LUV1; TCS3
product: Vps54p
transcript id: NM_001180335.1
SIO_010081: YDR027C
subclass of: SO_0000673
so part of: YDR027C
location: complement(<494649..>497318)
location: region:494649-497318:-1
so has part: feature:494649-497318:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494649-497318:-1:exon

YDR027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CGP1
alternative label: LUV1
alternative label: TCS3
gene: VPS54
locus tag: YDR027C
gene synonym: CGP1; LUV1; TCS3
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10637310]
experiment: EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10637310]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17645731]
experiment: EXISTENCE:mutant phenotype:GO:0090156 cellular sphingolipid homeostasis [PMID:26357016]
experiment: EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:10637310]
note: Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p
codon start: 1
product: Vps54p
translation: MSISETPHNKSQGLQKAAGRPKIVVPEGSPSRNSDSGSFTIEGDTSLNDDLLSISGSVTPRARRSSRLSLDSITPRRSFDSRTLSVANSRSFGFENETHSGSMDFSPLGNNSIYEIVMNTRRKNWLNYPTVADIPQVSLSKNDLDDHWKTHVIEYVKNIKSDYQIFQSTNNIRNMNQMEQLKELREGENMHEESFEANLRQGDAELINSIPDFYFSDKFQLDNPRTFHKVLDAIDLFLTKLDMKRQAERDEAFSELRDRLNDFLDIVETLLVTEISKSSHKFFHALSEVDNIQKRALDTMSELKELAQNIKTIDAENIRKKISHLEMIFKRKNVEKLEQGLLQAKLVLNKTDECKSMYEENKLDNCLELIKSIDYLIKGDDSINEDVQSWTRCWPYKLSNLRTIPALSATREFLTNMKIEIGGKFSLQLSILLIDDLRSFCKSIKPKETLHRIQTGSNDKKQTIFTDNFSSKITELIVRLNRCEELTSAFDLYREKSITELKSIIKIYLPTENAHADNNHDEKHLNNGSTSGSKLSRLIKEQTPAEFQSMLVNIFTHALEALRRLYGHQKLLLDISLNELASVKSPNENQHNMITQLDIRTGINEIIRIIQLRTGKIIAVRRELNLSLRYDYFLKFYAICVIFIQECEVLSGEFLTKYLSNVLASQIKHYANAQSSKNYRNIKKKIDAEEWIPYIVDSSIQSDVNDIVSSIDIDPLSWTTILDMVGGSHDCENGRSEDKEKDEGNETYQGHRKSVVVGDKTFVASSSLLATIEVIKELMVLSINLPSIYLSNFEKLCYDALQYYNSSAMASVTQPGNSLLKTGRNLSIMGESLDCLAEFVIIVQRFYQRLSNSNRDFEPFDASHYTTLLGQFQASSNKIYMANAPPPPV
SIO_010081: YDR027C
subclass of: SO_0000673
so part of: YDR027C
location: complement(494649..497318)
location: region:494649-497318:-1
so has part: feature:494649-497318:-1:exon

NP_010310.1
type: Protein
SIO_000068: ncbiprotein

S000002434
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494649-497318:-1:exon

YDR028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEX2
alternative label: PZF240
alternative label: SPP43
alternative label: SRN1
gene: REG1
locus tag: YDR028C
gene synonym: HEX2; PZF240; SPP43; SRN1
so part of: sequence
location: complement(<497835..>500879)
location: region:497835-500879:-1
so has part: feature:497835-500879:-1:exon
subclass of: SO_0000010

851592
type: Gene
SIO_000068: ncbigene

position:497835:-1
position: 497835
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:500879:-1
position: 500879
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497835-500879:-1:exon

YDR028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEX2
alternative label: PZF240
alternative label: SPP43
alternative label: SRN1
gene: REG1
locus tag: YDR028C
gene synonym: HEX2; PZF240; SPP43; SRN1
product: protein phosphatase regulator REG1
transcript id: NM_001180336.1
SIO_010081: YDR028C
subclass of: SO_0000673
so part of: YDR028C
location: complement(<497835..>500879)
location: region:497835-500879:-1
so has part: feature:497835-500879:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:497835-500879:-1:exon

YDR028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEX2
alternative label: PZF240
alternative label: SPP43
alternative label: SRN1
gene: REG1
locus tag: YDR028C
gene synonym: HEX2; PZF240; SPP43; SRN1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10454550]
experiment: EXISTENCE:direct assay:GO:0007039 protein catabolic process in the vacuole [PMID:14684743]
experiment: EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:25730376]
experiment: EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:14684743]
experiment: EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:19723765]
experiment: EXISTENCE:mutant phenotype:GO:0043433 negative regulation of DNA-binding transcription factor activity [PMID:12167649]
note: Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog, REG2, that arose from the whole genome duplication
codon start: 1
product: protein phosphatase regulator REG1
translation: MSTNLANYFAGKKDIENEHVNRNASHESNSKSDVKISGNDNDNDEDMGPSVSMAVQAKNDDDFHKSTFNLKRTRSMGLLDEYIDPTKKLLGRSDDLYDNDNEYYDNSSNNSSSNSSDDDYDDGYQEHSTSVSPPPADNDSYLIPQDDNDVVVEPERHVDYLSHEWKESEISNSWKYIILKKKKRDVDLVNAARLENASWRTWAKARNNLKTVSPEVVNWSKDSDVTWLYGPIVRDSEGNAQSEEEHDLERGYGSDDENSKRISMPTKNSKSIAAAPKPILKKRTVTEIIEDNALWKLNEARKHMTEMKHASVIMDPNGNKNVHDDFDALAAQVNAQYYHYPKESNSSVSLKSQHSDKKDNSTIPNPVGENSNGGGDKGEEDLHLKSALHVQNNRSTAQSNKSILENSTNDRKANLDQNLNSPDNNRFPSSTSSSNRDNENNSMGLSSILTSNPSEKSNKPTKNRHIHFNDRVEQCMALRYPASQSEDDESDDENKQYVDVNNNANVTTINNNRTPLLAIQHKSIPINSATEHLNKNTSDDDTSSQSSSSSHSDDEEHGGLYINARFSRRSDSGVHSPITDNSSVASSTTSRAHVRPIIKLLPDTTLNYGSDEESDNGEFNGYGNAVSHNVNTSRGYDYIYDYNSVYTGDTSSFLPVDSCDIVDVPEGMDLQTAIADDNASNYEFNNAVESKEKHVPQLHKASANNTTRQHGSHMLLYDDDNYSSSSDSEQQFIEDSQYNSSDDEEEEDDDDQEVDDNHDEGLSLRRTLSLGKSGSTNSLYDLAQPSLSSATPQQKNPTNFTGGKTDVDKDAQLAVRPYPLKRNSSSGNFIFNSDSEEESSSEEEQRPLPANSQLVNRSVLKGSVTPANISSQKKKALPKQPKASDSSQSFRIVNNTPSPAEVGASDVAIEGYFSPRNESIKSVVSGGNMMDHQDHSEMDTLAKGFENCHINNASKLKDKKVDSVQTTRKEASLTDSSNESLHKVVQNARGMASKYLHSWKKSDVKPQENGNDSS
SIO_010081: YDR028C
subclass of: SO_0000673
so part of: YDR028C
location: complement(497835..500879)
location: region:497835-500879:-1
so has part: feature:497835-500879:-1:exon

NP_010311.1
type: Protein
SIO_000068: ncbiprotein

S000002435
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:497835-500879:-1:exon

YDR029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR029W
so part of: sequence
location: <501100..>501414
location: region:501100-501414:1
so has part: feature:501100-501414:1:exon
subclass of: SO_0000010

851593
type: Gene
SIO_000068: ncbigene

position:501100:1
position: 501100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:501414:1
position: 501414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501100-501414:1:exon

YDR029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR029W
product: uncharacterized protein
transcript id: NM_001348809.1
SIO_010081: YDR029W
subclass of: SO_0000673
so part of: YDR029W
location: <501100..>501414
location: region:501100-501414:1
so has part: feature:501100-501414:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:501100-501414:1:exon

YDR029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR029W
note: hypothetical protein; conserved among S. cerevisiae strains; YDR029W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSKYYILIELMNDKKNTNSSCDIFSFYLNFSDNPFSSFRLKSRLLYGIFSCFLLFYSLKDLIGVFKQKYLYLSILLLWLLVLLFCLAKGLSHNLRADSFLQYPL
SIO_010081: YDR029W
subclass of: SO_0000673
so part of: YDR029W
location: 501100..501414
location: region:501100-501414:1
so has part: feature:501100-501414:1:exon

NP_001335755.1
type: Protein
SIO_000068: ncbiprotein

S000002436
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:501100-501414:1:exon

YDR030C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD28
locus tag: YDR030C
so part of: sequence
location: complement(<501753..>503273)
location: region:501753-503273:-1
so has part: feature:501753-503273:-1:exon
subclass of: SO_0000010

851594
type: Gene
SIO_000068: ncbigene

position:501753:-1
position: 501753
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:503273:-1
position: 503273
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501753-503273:-1:exon

YDR030C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD28
locus tag: YDR030C
product: Rad28p
transcript id: NM_001180338.3
SIO_010081: YDR030C
subclass of: SO_0000673
so part of: YDR030C
location: complement(<501753..>503273)
location: region:501753-503273:-1
so has part: feature:501753-503273:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:501753-503273:-1:exon

YDR030C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD28
locus tag: YDR030C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:8830695]
experiment: EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:8830695]
note: Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
codon start: 1
product: Rad28p
translation: MDPFLEFRVGNISLNEFYRRTIQSEFERILEDPLSNMKNYRFSKQSNYSTKEKTPLSIGVNCLDIDDTGQVLLGGGDDGSLSIWGLDESLHRNDEGEQELINKRLNYIKRQPHQSDDEPAQIMGYKNKRTRINDNNTMRLVHSFQTQRNKYRMYRQSSAAVPVQRSHISNKTDSPIGFSETLSETDSEASISHHKYGITTLKWYKADNGMFFTGSNDKTVKIWDTNRFEAVQDINLGYKINQIDNNVVDDSSLLVVASEDYYPRLIDLRTMNSGVTALGMGNQTRMQSEILCCKFNPVREQIIACGDMEGGVKLWDLRMRNRLYSELKRNKNRFKTINNDDNDDQSDVYFSSNQSKAHLRCCSDIVWNSEGSELCSVGMDGKLNVWRPFTEILQPEGLASYSQLGTQDLSRIKYKKRVSRRLLWFDKFLLCITDNGEVEIYNTEEKKLWNKLEYPMVNQVKKNQASHCQFSSMIVQTNIMNSVGLKLFFGTNNNTVSDGGSIFECS
SIO_010081: YDR030C
subclass of: SO_0000673
so part of: YDR030C
location: complement(501753..503273)
location: region:501753-503273:-1
so has part: feature:501753-503273:-1:exon

NP_010313.3
type: Protein
SIO_000068: ncbiprotein

S000002437
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:501753-503273:-1:exon

YDR031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MIC14
gene: MIX14
locus tag: YDR031W
gene synonym: MIC14
so part of: sequence
location: <503498..>503863
location: region:503498-503863:1
so has part: feature:503498-503863:1:exon
subclass of: SO_0000010

851595
type: Gene
SIO_000068: ncbigene

position:503498:1
position: 503498
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:503863:1
position: 503863
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503498-503863:1:exon

YDR031W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MIC14
gene: MIX14
locus tag: YDR031W
gene synonym: MIC14
product: Mix14p
transcript id: NM_001180339.3
SIO_010081: YDR031W
subclass of: SO_0000673
so part of: YDR031W
location: <503498..>503863
location: region:503498-503863:1
so has part: feature:503498-503863:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:503498-503863:1:exon

YDR031W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MIC14
gene: MIX14
locus tag: YDR031W
gene synonym: MIC14
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17095012]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:19703468]
note: Mitochondrial intermembrane space hypothetical protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
codon start: 1
product: Mix14p
translation: MSDILDEIVIEDVVANCPQEFLQYHKCIRDNEENPGKCKDGRMILSTCIREKVPSVKSIMSECSEPMKKYDQCIRDNMGTRTINENCLGFLQDLRKCAELQVKNKNIKPSINGVNLELIKD
SIO_010081: YDR031W
subclass of: SO_0000673
so part of: YDR031W
location: 503498..503863
location: region:503498-503863:1
so has part: feature:503498-503863:1:exon

NP_010314.4
type: Protein
SIO_000068: ncbiprotein

S000002438
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:503498-503863:1:exon

YDR032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PST2
locus tag: YDR032C
so part of: sequence
location: complement(<504099..>504695)
location: region:504099-504695:-1
so has part: feature:504099-504695:-1:exon
subclass of: SO_0000010

851596
type: Gene
SIO_000068: ncbigene

position:504099:-1
position: 504099
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:504695:-1
position: 504695
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:504099-504695:-1:exon

YDR032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PST2
locus tag: YDR032C
product: flavodoxin-like fold family protein
transcript id: NM_001180340.1
SIO_010081: YDR032C
subclass of: SO_0000673
so part of: YDR032C
location: complement(<504099..>504695)
location: region:504099-504695:-1
so has part: feature:504099-504695:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:504099-504695:-1:exon

YDR032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PST2
locus tag: YDR032C
experiment: EXISTENCE:direct assay:GO:0003955 NAD(P)H dehydrogenase (quinone) activity [PMID:28499769]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:19064668]
note: FMN-dependent NAD(P)H:quinone oxidoreductase; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
codon start: 1
product: flavodoxin-like fold family protein
translation: MPRVAIIIYTLYGHVAATAEAEKKGIEAAGGSADIYQVEETLSPEVVKALGGAPKPDYPIATQDTLTEYDAFLFGIPTRFGNFPAQWKAFWDRTGGLWAKGALHGKVAGCFVSTGTGGGNEATIMNSLSTLAHHGIIFVPLGYKNVFAELTNMDEVHGGSPWGAGTIAGSDGSRSPSALELQVHEIQGKTFYETVAKF
SIO_010081: YDR032C
subclass of: SO_0000673
so part of: YDR032C
location: complement(504099..504695)
location: region:504099-504695:-1
so has part: feature:504099-504695:-1:exon

NP_010315.1
type: Protein
SIO_000068: ncbiprotein

S000002439
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:504099-504695:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS450; Autonomously Replicating Sequence
so part of: sequence
location: 505343..505584
location: region:505343-505584:1
so has part: feature:505343-505584:1:region

S000119069
type: SGD
SIO_000068: sgd

position:505343:1
position: 505343
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:505584:1
position: 505584
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:505343-505584:1:region

YDR033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRH1
locus tag: YDR033W
so part of: sequence
location: <508147..>509109
location: region:508147-509109:1
so has part: feature:508147-509109:1:exon
subclass of: SO_0000010

851597
type: Gene
SIO_000068: ncbigene

position:508147:1
position: 508147
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:509109:1
position: 509109
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:508147-509109:1:exon

YDR033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRH1
locus tag: YDR033W
product: Mrh1p
transcript id: NM_001180341.1
SIO_010081: YDR033W
subclass of: SO_0000673
so part of: YDR033W
location: <508147..>509109
location: region:508147-509109:1
so has part: feature:508147-509109:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:508147-509109:1:exon

YDR033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRH1
locus tag: YDR033W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10675524|PMID:12469340|PMID:16622836]
note: Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid
codon start: 1
product: Mrh1p
translation: MSTFETLIKRGGNEAIKINPPTGADFHITSRGSDWFWTCFCCYLLFGLILTFLMFRKPVNDRFFYLTGIAPNFFMCIAYFTMASNLGWIPVKAKYNHVQTSTQKEHPGYRQIFYSRFVGWFLALPWPIIQICMLAGTPFWQMAFNVCITEFFTVCWLIAACVHSTYKWGYYTIGLGAAIVVSISVMTTSYNLVKQRDNDIRLTFLVFFSIIMFLWIIAYPTCFGITDGGNVLQPDSAGIFYGIIDLILMCFIPTLLVPIANHFGADKLGYHFGPSDAEAVMAPKAPVASPRPAATPNLSKDKKKKSKKSKKSKKSKKSEE
SIO_010081: YDR033W
subclass of: SO_0000673
so part of: YDR033W
location: 508147..509109
location: region:508147-509109:1
so has part: feature:508147-509109:1:exon

NP_010316.1
type: Protein
SIO_000068: ncbiprotein

S000002440
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:508147-509109:1:exon

YDR034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LYS14
locus tag: YDR034C
so part of: sequence
location: complement(<509737..>512109)
location: region:509737-512109:-1
so has part: feature:509737-512109:-1:exon
subclass of: SO_0000010

851598
type: Gene
SIO_000068: ncbigene

position:509737:-1
position: 509737
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:512109:-1
position: 512109
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:509737-512109:-1:exon

YDR034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LYS14
locus tag: YDR034C
product: Lys14p
transcript id: NM_001180342.3
SIO_010081: YDR034C
subclass of: SO_0000673
so part of: YDR034C
location: complement(<509737..>512109)
location: region:509737-512109:-1
so has part: feature:509737-512109:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:509737-512109:-1:exon

YDR034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LYS14
locus tag: YDR034C
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9701810]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10975256]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11952910|PMID:7935367]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3123231]
experiment: EXISTENCE:mutant phenotype:GO:2001196 positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine [PMID:3123231]
note: Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
codon start: 1
product: Lys14p
translation: MFESVNLDENSPEDRELAKVLSPPGSYLSPASLDSGSSFTNSGTSTSCFEPKNNLPSLSFLNARAGSLGGIFNHKQMTSPSNSNIGGENVESTTSSNDGSNENAGHPTTSEQDQNADHPTISQADDNGHSSLTPNPAVTSTVTDKKGNTVKRKYSRNGCSECKRRRMKCDETKPTCWQCARLNRQCVYVLNPKNKKRRTSNAQRVKEFRKHSTSLDNDHNNARKRQHSSCKAEKKKKVRQNLSEDTTDPKPITDNGKNVPLDEIESLEIPNLDLTTTMNGYDVNLLMQNLNDMVNMKLHDSYLLNEELKGLDLPDLDIPELLPASNVNSSVPISFLVNNVITFNTKLSSFKLGGIHDKYLKIFYYDCLDSIAPFFQNQGNPLRDILLSFAKNEAYLLSSILATGASIAYRKSNNLEDERNYCAYLSHCLSLLGEQFKNESNVLNRIEPIILTVIMLAWDCIYSMNSQWRSHLKGVTDLFKKINAGNSSKVLNVAKCWFKVMETFASISTVFGGSLIDNNDLDAIFDPYDYQYVDSLKFLNIMTPLNEFNLLRGHKEDFDLVIKEVFKSLNTIRSTEKNYFSKEEGLFTKKLDYLLLSSQTSSEKSKDQISYFNTQKILVEIDKQLDYEFIDKSGIIPSDNQSHPRISNIHDNAIDMVTLKNGEEVAISWYDISHQTQVLSFLLIVLLKLLGMPKESSTIQQVVKKIMSFFKFLDSDSPPQNSRTCYSNFAVLIAGLNAMDEETRAIVKRYYKINGGKFQKLTEHNLNRLEKVWYGKNQNYRLEEQDVLTW
SIO_010081: YDR034C
subclass of: SO_0000673
so part of: YDR034C
location: complement(509737..512109)
location: region:509737-512109:-1
so has part: feature:509737-512109:-1:exon

NP_010317.3
type: Protein
SIO_000068: ncbiprotein

S000002441
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:509737-512109:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(512986..513258)
location: region:512986-513258:-1
so has part: feature:512986-513258:-1:region

S000006844
type: SGD
SIO_000068: sgd

position:512986:-1
position: 512986
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:513258:-1
position: 513258
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:512986-513258:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(513259..513590)
location: region:513259-513590:-1
so has part: feature:513259-513590:-1:region

S000006845
type: SGD
SIO_000068: sgd

position:513259:-1
position: 513259
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:513590:-1
position: 513590
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513259-513590:-1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YDRCTy2-1; Ty2 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YDRCTy2-1
so part of: sequence
location: complement(513692..519647)
location: region:513692-519647:-1
so has part: feature:513692-519647:-1:region

S000006862
type: SGD
SIO_000068: sgd

position:513692:-1
position: 513692
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:519647:-1
position: 519647
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513692-519647:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(513692..514020)
location: region:513692-514020:-1
so has part: feature:513692-514020:-1:region

S000006846
type: SGD
SIO_000068: sgd

position:514020:-1
position: 514020
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513692-514020:-1:region

YDR034C-D
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR034C-D
so part of: sequence
location: complement(<514043..>519356)
location: region:514043-519356:-1
so has part: feature:514043-519356:-1:exon
subclass of: SO_0000010

851599
type: Gene
SIO_000068: ncbigene

position:514043:-1
position: 514043
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:519356:-1
position: 519356
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:514043-519356:-1:exon

YDR034C-D
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR034C-D
product: gag-pol fusion protein
transcript id: NM_001184379.4
SIO_010081: YDR034C-D
subclass of: SO_0000673
so part of: YDR034C-D
location: complement(<514043..>519356)
location: region:514043-519356:-1
so has part: feature:514043-519356:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:514043-519356:-1:exon

YDR034C-D
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR034C-D
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQNSPNLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDLKNQHSEIPQAKTKVGNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYQRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTHTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQDKQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEKNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSINPLQLDKEPVQKVRAPKEVDADISEYNILPSTIRSRTPHIINKESTEMGGTIESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAACDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTNKSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNEDNKEKDRYIEAYHKEINQLLRMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGEGDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YDR034C-D
subclass of: SO_0000673
so part of: YDR034C-D
location: complement(join(514043..518062,518064..519356))
location: region:514043-519356:-1
so has part: feature:518064-519356:-1:exon
so has part: feature:514043-518062:-1:exon

NP_058138.3
type: Protein
SIO_000068: ncbiprotein

S000007345
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:518064-519356:-1:exon

position:518064:-1
position: 518064
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:514043-518062:-1:exon

position:518062:-1
position: 518062
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDR034C-C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR034C-C
so part of: sequence
location: complement(<518040..>519356)
location: region:518040-519356:-1
so has part: feature:518040-519356:-1:exon
subclass of: SO_0000010

851600
type: Gene
SIO_000068: ncbigene

position:518040:-1
position: 518040
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:518040-519356:-1:exon

YDR034C-C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR034C-C
product: gag protein
transcript id: NM_001184378.1
SIO_010081: YDR034C-C
subclass of: SO_0000673
so part of: YDR034C-C
location: complement(<518040..>519356)
location: region:518040-519356:-1
so has part: feature:518040-519356:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:518040-519356:-1:exon

YDR034C-C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR034C-C
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQNSPNLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDLKNQHSEIPQAKTKVGNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYQRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI
SIO_010081: YDR034C-C
subclass of: SO_0000673
so part of: YDR034C-C
location: complement(518040..519356)
location: region:518040-519356:-1
so has part: feature:518040-519356:-1:exon

NP_058139.1
type: Protein
SIO_000068: ncbiprotein

S000007344
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:518040-519356:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(519316..519647)
location: region:519316-519647:-1
so has part: feature:519316-519647:-1:region

S000006847
type: SGD
SIO_000068: sgd

position:519316:-1
position: 519316
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519316-519647:-1:region

YNCD0008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0008W
so part of: sequence
location: 519743..519826
location: region:519743-519826:1
so has part: feature:519743-519826:1:exon
subclass of: SO_0000663

851601
type: Gene
SIO_000068: ncbigene

position:519743:1
position: 519743
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:519826:1
position: 519826
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519743-519826:1:exon

YNCD0008W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0008W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCD0008W
subclass of: SO_0000673
so part of: YNCD0008W
location: 519743..519826
location: region:519743-519826:1
so has part: feature:519743-519826:1:exon

S000006649
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519743-519826:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(520173..520475)
location: region:520173-520475:-1
so has part: feature:520173-520475:-1:region

S000006848
type: SGD
SIO_000068: sgd

position:520173:-1
position: 520173
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:520475:-1
position: 520475
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520173-520475:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 520477..520805
location: region:520477-520805:1
so has part: feature:520477-520805:1:region

S000006863
type: SGD
SIO_000068: sgd

position:520477:1
position: 520477
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:520805:1
position: 520805
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520477-520805:1:region

YDR034C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR034C-A
so part of: sequence
location: complement(<520516..>520692)
location: region:520516-520692:-1
so has part: feature:520516-520692:-1:exon
subclass of: SO_0000010

851602
type: Gene
SIO_000068: ncbigene

position:520516:-1
position: 520516
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520692:-1
position: 520692
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520516-520692:-1:exon

YDR034C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR034C-A
product: uncharacterized protein
transcript id: NM_001184326.1
SIO_010081: YDR034C-A
subclass of: SO_0000673
so part of: YDR034C-A
location: complement(<520516..>520692)
location: region:520516-520692:-1
so has part: feature:520516-520692:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:520516-520692:-1:exon

YDR034C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR034C-A
note: hypothetical protein; contained within the solo Ty1 LTR element YDRWdelta7
codon start: 1
product: uncharacterized protein
translation: MESIFLHANITIIPHSVLYVSLSYYIINPCVSVSTNLDDYFSSFVSSSNTVYDNILVT
SIO_010081: YDR034C-A
subclass of: SO_0000673
so part of: YDR034C-A
location: complement(520516..520692)
location: region:520516-520692:-1
so has part: feature:520516-520692:-1:exon

NP_010318.1
type: Protein
SIO_000068: ncbiprotein

S000007233
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:520516-520692:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(520806..520833)
location: region:520806-520833:-1
so has part: feature:520806-520833:-1:region

S000006849
type: SGD
SIO_000068: sgd

position:520806:-1
position: 520806
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:520833:-1
position: 520833
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520806-520833:-1:region

YNCD0009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0009W
so part of: sequence
location: 520972..521043
location: region:520972-521043:1
so has part: feature:520972-521043:1:exon
subclass of: SO_0000663

851603
type: Gene
SIO_000068: ncbigene

position:520972:1
position: 520972
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:521043:1
position: 521043
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520972-521043:1:exon

YNCD0009W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0009W
product: tRNA-Gln
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
note: Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCD0009W
subclass of: SO_0000673
so part of: YNCD0009W
location: 520972..521043
location: region:520972-521043:1
so has part: feature:520972-521043:1:exon

S000006693
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:520972-521043:1:exon

YDR034W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR034W-B
so part of: sequence
location: <521314..>521469
location: region:521314-521469:1
so has part: feature:521314-521469:1:exon
subclass of: SO_0000010

851604
type: Gene
SIO_000068: ncbigene

position:521314:1
position: 521314
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:521469:1
position: 521469
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:521314-521469:1:exon

YDR034W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR034W-B
product: uncharacterized protein
transcript id: NM_001184327.3
SIO_010081: YDR034W-B
subclass of: SO_0000673
so part of: YDR034W-B
location: <521314..>521469
location: region:521314-521469:1
so has part: feature:521314-521469:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:521314-521469:1:exon

YDR034W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR034W-B
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Predicted tail-anchored plasma membrane protein; contains conserved CYSTM module; related proteins in other organisms may be involved in response to stress; N- and C-terminal fusion proteins localize to the cell periphery; YDR034W-B has a paralog, YBR056W-A, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MRHHQNMHYAPQQQPVYVQQPPPRRESGGCCRTCCHFLCCLCLINLCCDVF
SIO_010081: YDR034W-B
subclass of: SO_0000673
so part of: YDR034W-B
location: 521314..521469
location: region:521314-521469:1
so has part: feature:521314-521469:1:exon

NP_010319.3
type: Protein
SIO_000068: ncbiprotein

S000007234
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:521314-521469:1:exon

YDR035W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARO3
locus tag: YDR035W
so part of: sequence
location: <521816..>522928
location: region:521816-522928:1
so has part: feature:521816-522928:1:exon
subclass of: SO_0000010

851605
type: Gene
SIO_000068: ncbigene

position:521816:1
position: 521816
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:522928:1
position: 522928
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:521816-522928:1:exon

YDR035W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARO3
locus tag: YDR035W
product: 3-deoxy-7-phosphoheptulonate synthase ARO3
transcript id: NM_001180343.3
SIO_010081: YDR035W
subclass of: SO_0000673
so part of: YDR035W
location: <521816..>522928
location: region:521816-522928:1
so has part: feature:521816-522928:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:521816-522928:1:exon

YDR035W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARO3
locus tag: YDR035W
EC number: 2.5.1.54
experiment: EXISTENCE:direct assay:GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity [PMID:2880280]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
codon start: 1
product: 3-deoxy-7-phosphoheptulonate synthase ARO3
translation: MFIKNDHAGDRKRLEDWRIKGYDPLTPPDLLQHEFPISAKGEENIIKARDSVCDILNGKDDRLVIVIGPCSLHDPKAAYDYADRLAKISEKLSKDLLIIMRAYLEKPRTTVGWKGLINDPDMNNSFQINKGLRISREMFIKLVEKLPIAGEMLDTISPQFLSDCFSLGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLQVAIDAMRAAAHEHYFLSVTKPGVTAIVGTEGNKDTFLILRGGKNGTNFDKESVQNTKKQLEKAGLTDDSQKRIMIDCSHGNSNKDFKNQPKVAKCIYDQLTEGENSLCGVMIESNINEGRQDIPKEGGREGLKYGCSVTDACIGWESTEQVLELLAEGVRNRRKALKK
SIO_010081: YDR035W
subclass of: SO_0000673
so part of: YDR035W
location: 521816..522928
location: region:521816-522928:1
so has part: feature:521816-522928:1:exon

NP_010320.3
type: Protein
SIO_000068: ncbiprotein

S000002442
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:521816-522928:1:exon

YDR036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mS47
gene: EHD3
locus tag: YDR036C
gene synonym: mS47
so part of: sequence
location: complement(<523211..>524713)
location: region:523211-524713:-1
so has part: feature:523211-524713:-1:exon
subclass of: SO_0000010

851606
type: Gene
SIO_000068: ncbigene

position:523211:-1
position: 523211
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:524713:-1
position: 524713
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523211-524713:-1:exon

YDR036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mS47
gene: EHD3
locus tag: YDR036C
gene synonym: mS47
product: 3-hydroxyisobutyryl-CoA hydrolase
transcript id: NM_001180344.1
SIO_010081: YDR036C
subclass of: SO_0000673
so part of: YDR036C
location: complement(<523211..>524713)
location: region:523211-524713:-1
so has part: feature:523211-524713:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523211-524713:-1:exon

YDR036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mS47
gene: EHD3
locus tag: YDR036C
gene synonym: mS47
EC number: 3.1.2.4
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity [PMID:12697341]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095|PMID:16823961|PMID:14576278|P MID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]
note: 3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
codon start: 1
product: 3-hydroxyisobutyryl-CoA hydrolase
translation: MLRNTLKCAQLSSKYGFKTTTRTFMTTQPQLNVTDAPPVLFTVQDTARVITLNRPKKLNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIFNFNKEFAKSIKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATENTKWAMPEMDIGFFPDVGSTFALPRIVTLANSNSQMALYLCLTGEVVTGADAYMLGLASHYVSSENLDALQKRLGEISPPFNNDPQSAYFFGMVNESIDEFVSPLPKDYVFKYSNEKLNVIEACFNLSKNGTIEDIMNNLRQYEGSAEGKAFAQEIKTKLLTKSPSSLQIALRLVQENSRDHIESAIKRDLYTAANMCMNQDSLVEFSEATKHKLIDKQRVPYPWTKKEQLFVSQLTSITSPKPSLPMSLLRNTSNVTWTQYPYHSKYQLPTEQEIAAYIEKRTNDDTGAKVTEREVLNHFANVIPSRRGKLGIQSLCKIVCERKCEEVNDGLRWK
SIO_010081: YDR036C
subclass of: SO_0000673
so part of: YDR036C
location: complement(523211..524713)
location: region:523211-524713:-1
so has part: feature:523211-524713:-1:exon

NP_010321.1
type: Protein
SIO_000068: ncbiprotein

S000002443
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523211-524713:-1:exon

YDR037W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GCD5
gene: KRS1
locus tag: YDR037W
gene synonym: GCD5
so part of: sequence
location: <525440..>527215
location: region:525440-527215:1
so has part: feature:525440-527215:1:exon
subclass of: SO_0000010

851607
type: Gene
SIO_000068: ncbigene

position:525440:1
position: 525440
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:527215:1
position: 527215
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:525440-527215:1:exon

YDR037W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GCD5
gene: KRS1
locus tag: YDR037W
gene synonym: GCD5
product: lysine--tRNA ligase KRS1
transcript id: NM_001180345.1
SIO_010081: YDR037W
subclass of: SO_0000673
so part of: YDR037W
location: <525440..>527215
location: region:525440-527215:1
so has part: feature:525440-527215:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:525440-527215:1:exon

YDR037W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GCD5
gene: KRS1
locus tag: YDR037W
gene synonym: GCD5
EC number: 6.1.1.6
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004824 lysine-tRNA ligase activity [PMID:3888626]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:330225]
experiment: EXISTENCE:direct assay:GO:0006430 lysyl-tRNA aminoacylation [PMID:3888626]
experiment: EXISTENCE:mutant phenotype:GO:0004824 lysine-tRNA ligase activity [PMID:7628447]
experiment: EXISTENCE:mutant phenotype:GO:0006430 lysyl-tRNA aminoacylation [PMID:7628447]
note: Lysyl-tRNA synthetase
codon start: 1
product: lysine--tRNA ligase KRS1
translation: MSQQDNVKAAAEGVANLHLDEATGEMVSKSELKKRIKQRQVEAKKAAKKAAAQPKPASKKKTDLFADLDPSQYFETRSRQIQELRKTHEPNPYPHKFHVSISNPEFLAKYAHLKKGETLPEEKVSIAGRIHAKRESGSKLKFYVLHGDGVEVQLMSQLQDYCDPDSYEKDHDLLKRGDIVGVEGYVGRTQPKKGGEGEVSVFVSRVQLLTPCLHMLPADHFGFKDQETRYRKRYLDLIMNKDARNRFITRSEIIRYIRRFLDQRKFIEVETPMMNVIAGGATAKPFITHHNDLDMDMYMRIAPELFLKQLVVGGLDRVYEIGRQFRNEGIDMTHNPEFTTCEFYQAYADVYDLMDMTELMFSEMVKEITGSYIIKYHPDPADPAKELELNFSRPWKRINMIEELEKVFNVKFPSGDQLHTAETGEFLKKILVDNKLECPPPLTNARMLDKLVGELEDTCINPTFIFGHPQMMSPLAKYSRDQPGLCERFEVFVATKEICNAYTELNDPFDQRARFEEQARQKDQGDDEAQLVDETFCNALEYGLPPTGGWGCGIDRLAMFLTDSNTIREVLLFPTLKPDVLREEVKKEEEN
SIO_010081: YDR037W
subclass of: SO_0000673
so part of: YDR037W
location: 525440..527215
location: region:525440-527215:1
so has part: feature:525440-527215:1:exon

NP_010322.1
type: Protein
SIO_000068: ncbiprotein

S000002444
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:525440-527215:1:exon

YDR038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENA5
locus tag: YDR038C
so part of: sequence
location: complement(<527422..>530697)
location: region:527422-530697:-1
so has part: feature:527422-530697:-1:exon
subclass of: SO_0000010

851608
type: Gene
SIO_000068: ncbigene

position:527422:-1
position: 527422
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:530697:-1
position: 530697
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:527422-530697:-1:exon

YDR038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENA5
locus tag: YDR038C
product: putative Na(+)-exporting P-type ATPase ENA5
transcript id: NM_001180346.3
SIO_010081: YDR038C
subclass of: SO_0000673
so part of: YDR038C
location: complement(<527422..>530697)
location: region:527422-530697:-1
so has part: feature:527422-530697:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:527422-530697:-1:exon

YDR038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENA5
locus tag: YDR038C
EC number: 7.2.2.3
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family
codon start: 1
product: putative Na(+)-exporting P-type ATPase ENA5
translation: MSEGTVKENNNEEFNAYHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVISMAISFAVRDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIYAICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHNETYNIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLMDRPPNDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINSGRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPIGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNSENDLERSSKHDPFEAYSTSTTLQSEINISVKH
SIO_010081: YDR038C
subclass of: SO_0000673
so part of: YDR038C
location: complement(527422..530697)
location: region:527422-530697:-1
so has part: feature:527422-530697:-1:exon

NP_010323.3
type: Protein
SIO_000068: ncbiprotein

S000002445
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:527422-530697:-1:exon

YDR039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENA2
locus tag: YDR039C
so part of: sequence
location: complement(<531307..>534582)
location: region:531307-534582:-1
so has part: feature:531307-534582:-1:exon
subclass of: SO_0000010

851609
type: Gene
SIO_000068: ncbigene

position:531307:-1
position: 531307
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:534582:-1
position: 534582
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:531307-534582:-1:exon

YDR039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENA2
locus tag: YDR039C
product: Na(+)-exporting P-type ATPase ENA2
transcript id: NM_001180347.3
SIO_010081: YDR039C
subclass of: SO_0000673
so part of: YDR039C
location: complement(<531307..>534582)
location: region:531307-534582:-1
so has part: feature:531307-534582:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:531307-534582:-1:exon

YDR039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENA2
locus tag: YDR039C
EC number: 7.2.2.3
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7664728]
experiment: EXISTENCE:genetic interaction:GO:0006814 sodium ion transport [PMID:10073572|PMID:1657642]
experiment: EXISTENCE:genetic interaction:GO:0008554 P-type sodium transporter activity [PMID:1657642]
experiment: EXISTENCE:genetic interaction:GO:0015662 P-type ion transporter activity [PMID:1657642]
experiment: EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:11932440]
experiment: EXISTENCE:mutant phenotype:GO:0008556 P-type potassium transmembrane transporter activity [PMID:11932440]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11932440]
note: P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
codon start: 1
product: Na(+)-exporting P-type ATPase ENA2
translation: MSEGTVKENNNEEFNAYHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVISMAISFAVRDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIYAICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHNETYNIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINSGRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPIGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNPENDLESNNKRDPFEAYSTSTTIHTEVNIGIKQ
SIO_010081: YDR039C
subclass of: SO_0000673
so part of: YDR039C
location: complement(531307..534582)
location: region:531307-534582:-1
so has part: feature:531307-534582:-1:exon

NP_010324.3
type: Protein
SIO_000068: ncbiprotein

S000002446
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:531307-534582:-1:exon

YDR040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HOR6
alternative label: PMR2
gene: ENA1
locus tag: YDR040C
gene synonym: HOR6; PMR2
so part of: sequence
location: complement(<535192..>538467)
location: region:535192-538467:-1
so has part: feature:535192-538467:-1:exon
subclass of: SO_0000010

851610
type: Gene
SIO_000068: ncbigene

position:535192:-1
position: 535192
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:538467:-1
position: 538467
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535192-538467:-1:exon

YDR040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HOR6
alternative label: PMR2
gene: ENA1
locus tag: YDR040C
gene synonym: HOR6; PMR2
product: Na(+)/Li(+)-exporting P-type ATPase ENA1
transcript id: NM_001180348.1
SIO_010081: YDR040C
subclass of: SO_0000673
so part of: YDR040C
location: complement(<535192..>538467)
location: region:535192-538467:-1
so has part: feature:535192-538467:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:535192-538467:-1:exon

YDR040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HOR6
alternative label: PMR2
gene: ENA1
locus tag: YDR040C
gene synonym: HOR6; PMR2
EC number: 7.2.2.3
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7664728|PMID:9315618|PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0008554 P-type sodium transporter activity [PMID:9315618]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:9315618]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0006814 sodium ion transport [PMID:1657642]
experiment: EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:8612770]
experiment: EXISTENCE:genetic interaction:GO:0008554 P-type sodium transporter activity [PMID:1657642]
experiment: EXISTENCE:genetic interaction:GO:0009268 response to pH [PMID:12453218]
experiment: EXISTENCE:genetic interaction:GO:0009651 response to salt stress [PMID:11457832]
experiment: EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:11932440]
experiment: EXISTENCE:mutant phenotype:GO:0008556 P-type potassium transmembrane transporter activity [PMID:11932440]
experiment: EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:9383192]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9315618]
note: P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance
codon start: 1
product: Na(+)/Li(+)-exporting P-type ATPase ENA1
translation: MGEGTTKENNNAEFNAYHTLTAEEAAEFIGTSLTEGLTQDEFVHRLKTVGENTLGDDTKIDYKAMVLHQVCNAMIMVLLISMIISFAMHDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDKRVAIYAICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHNETYNIYGKGAFESIISCCSSWYGKDGVKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCTMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINSGRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFVSAFPVVYIPVINDKVFLHKPIGAEWGLAIAFTIAFWIGAELYKCGKRRYFKTQRAHNPENDLESNNKRDPFEAYSTSTTIHTEVNIGIKQ
SIO_010081: YDR040C
subclass of: SO_0000673
so part of: YDR040C
location: complement(535192..538467)
location: region:535192-538467:-1
so has part: feature:535192-538467:-1:exon

NP_010325.1
type: Protein
SIO_000068: ncbiprotein

S000002447
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:535192-538467:-1:exon

YDR041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uS10m
gene: RSM10
locus tag: YDR041W
gene synonym: uS10m
so part of: sequence
location: <539803..>540414
location: region:539803-540414:1
so has part: feature:539803-540414:1:exon
subclass of: SO_0000010

851611
type: Gene
SIO_000068: ncbigene

position:539803:1
position: 539803
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:540414:1
position: 540414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:539803-540414:1:exon

YDR041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uS10m
gene: RSM10
locus tag: YDR041W
gene synonym: uS10m
product: mitochondrial 37S ribosomal protein RSM10
transcript id: NM_001180349.1
SIO_010081: YDR041W
subclass of: SO_0000673
so part of: YDR041W
location: <539803..>540414
location: region:539803-540414:1
so has part: feature:539803-540414:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:539803-540414:1:exon

YDR041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uS10m
gene: RSM10
locus tag: YDR041W
gene synonym: uS10m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
codon start: 1
product: mitochondrial 37S ribosomal protein RSM10
translation: MLRNTIALRSFIRTQSTRPYPVNVEAVYYAPLKLPIKYGDLVADIQLRSYDNENLDFYSDFILRTGYYLGIPLTGPKPLPTRRERWTVIKSPFVHAKSKENFERHTHKRLIRAWDTNPEVLQMLIAYITKHSMAGVGMKCNFFQRSEISLDLGSDANGLEKSLSNIDELYSLRNDDKAQTSAVGQKVLELLDSPDFKKHLEKK
SIO_010081: YDR041W
subclass of: SO_0000673
so part of: YDR041W
location: 539803..540414
location: region:539803-540414:1
so has part: feature:539803-540414:1:exon

NP_010326.1
type: Protein
SIO_000068: ncbiprotein

S000002448
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:539803-540414:1:exon

YDR042C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR042C
so part of: sequence
location: complement(<540601..>541203)
location: region:540601-541203:-1
so has part: feature:540601-541203:-1:exon
subclass of: SO_0000010

851612
type: Gene
SIO_000068: ncbigene

position:540601:-1
position: 540601
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:541203:-1
position: 541203
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:540601-541203:-1:exon

YDR042C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR042C
product: uncharacterized protein
transcript id: NM_001180350.3
SIO_010081: YDR042C
subclass of: SO_0000673
so part of: YDR042C
location: complement(<540601..>541203)
location: region:540601-541203:-1
so has part: feature:540601-541203:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:540601-541203:-1:exon

YDR042C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR042C
note: hypothetical protein; expression is increased in ssu72-ts69 mutant
codon start: 1
product: uncharacterized protein
translation: MEQILYNQSLKISTLSTFQGLKFLKVLIFSIFQQLFYNPVIQLFGTKASIMESDSTTLLESSWSTERNFLNMNSDSISATKNVFILFFTIFRLAEYIVYKLSDQKYRLHTSLNVQHFRWNSKKNTNRKRTLSFSKAYLPRTNILPIFVADGLKNRFSGPLPGKSLESFQKLNLLSDNNIKRYAVPGNKAVNTLLWQEQYS
SIO_010081: YDR042C
subclass of: SO_0000673
so part of: YDR042C
location: complement(540601..541203)
location: region:540601-541203:-1
so has part: feature:540601-541203:-1:exon

NP_010327.3
type: Protein
SIO_000068: ncbiprotein

S000002449
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:540601-541203:-1:exon

YNCD0010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR47
locus tag: YNCD0010C
so part of: sequence
location: complement(541602..541700)
location: region:541602-541700:-1
so has part: feature:541602-541700:-1:exon
subclass of: SO_0000578

9164877
type: Gene
SIO_000068: ncbigene

position:541602:-1
position: 541602
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:541700:-1
position: 541700
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541602-541700:-1:exon

YNCD0010C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR47
locus tag: YNCD0010C
product: SNR47
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position A2220 and small subunit (SSU) rRNA at position A619
transcript id: NR_132160.1
SIO_010081: YNCD0010C
subclass of: SO_0000673
so part of: YNCD0010C
location: complement(541602..541700)
location: region:541602-541700:-1
so has part: feature:541602-541700:-1:exon

S000006507
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:541602-541700:-1:exon

YDR043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NRG1
locus tag: YDR043C
so part of: sequence
location: complement(<542674..>543369)
location: region:542674-543369:-1
so has part: feature:542674-543369:-1:exon
subclass of: SO_0000010

851613
type: Gene
SIO_000068: ncbigene

position:542674:-1
position: 542674
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:543369:-1
position: 543369
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:542674-543369:-1:exon

YDR043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NRG1
locus tag: YDR043C
product: transcriptional regulator NRG1
transcript id: NM_001180351.3
SIO_010081: YDR043C
subclass of: SO_0000673
so part of: YDR043C
location: complement(<542674..>543369)
location: region:542674-543369:-1
so has part: feature:542674-543369:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:542674-543369:-1:exon

YDR043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NRG1
locus tag: YDR043C
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:17023428|PMID:10022891]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10022891]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11404322]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15466424|PMID:16278455|PMID:12024013]
experiment: EXISTENCE:genetic interaction:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:16278455]
experiment: EXISTENCE:genetic interaction:GO:0043709 cell adhesion involved in single-species biofilm formation [PMID:12024013]
experiment: EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:12024013]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18287536|PMID:12509465|PMID:17023428]
experiment: EXISTENCE:mutant phenotype:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:11281938|PMID:11404322|PMID:10022891]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10022891]
experiment: EXISTENCE:mutant phenotype:GO:0071475 cellular hyperosmotic salinity response [PMID:12509465]
experiment: EXISTENCE:mutant phenotype:GO:0090606 single-species surface biofilm formation [PMID:16556982]
experiment: EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12509465]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10022891]
experiment: EXISTENCE:physical interaction:GO:0071475 cellular hyperosmotic salinity response [PMID:12509465]
note: Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose
codon start: 1
product: transcriptional regulator NRG1
translation: MFYPYNYSNLNVSTMPALPGISAFDGMQDEENVEISPERKYQTLLPVLTNSHVVENELKHKLNKTAFDFRYQTKSENGSEKWEPKYLITPNLQTRSVSFDNSSVQYNSDSSEKSSLSQLTCNSSIIQQPENGIVSNDAYNKMANSRYSLKTRKQRTDPRNTLSDEEDLEQRRKYICKICARGFTTSGHLARHNRIHTGEKNHCCPYKGCTQRFSRHDNCLQHYRTHLKKGQ
SIO_010081: YDR043C
subclass of: SO_0000673
so part of: YDR043C
location: complement(542674..543369)
location: region:542674-543369:-1
so has part: feature:542674-543369:-1:exon

NP_010328.3
type: Protein
SIO_000068: ncbiprotein

S000002450
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:542674-543369:-1:exon

YDR044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HEM13
locus tag: YDR044W
so part of: sequence
location: <546642..>547628
location: region:546642-547628:1
so has part: feature:546642-547628:1:exon
subclass of: SO_0000010

851614
type: Gene
SIO_000068: ncbigene

position:546642:1
position: 546642
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547628:1
position: 547628
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546642-547628:1:exon

YDR044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HEM13
locus tag: YDR044W
product: coproporphyrinogen oxidase
transcript id: NM_001180352.1
SIO_010081: YDR044W
subclass of: SO_0000673
so part of: YDR044W
location: <546642..>547628
location: region:546642-547628:1
so has part: feature:546642-547628:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546642-547628:1:exon

YDR044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HEM13
locus tag: YDR044W
EC number: 1.3.3.3
experiment: EXISTENCE:direct assay:GO:0004109 coproporphyrinogen oxidase activity [PMID:3516695]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3516695]
experiment: EXISTENCE:mutant phenotype:GO:0004109 coproporphyrinogen oxidase activity [PMID:2838478]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824]
note: Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
codon start: 1
product: coproporphyrinogen oxidase
translation: MPAPQDPRNLPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAPGSREAKLLEVTTKPREWVK
SIO_010081: YDR044W
subclass of: SO_0000673
so part of: YDR044W
location: 546642..547628
location: region:546642-547628:1
so has part: feature:546642-547628:1:exon

NP_010329.1
type: Protein
SIO_000068: ncbiprotein

S000002451
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546642-547628:1:exon

YDR045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPC11
locus tag: YDR045C
so part of: sequence
location: complement(<547978..>548310)
location: region:547978-548310:-1
so has part: feature:547978-548310:-1:exon
subclass of: SO_0000010

851615
type: Gene
SIO_000068: ncbigene

position:547978:-1
position: 547978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:548310:-1
position: 548310
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:547978-548310:-1:exon

YDR045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPC11
locus tag: YDR045C
product: DNA-directed RNA polymerase III core subunit RPC11
transcript id: NM_001180353.1
SIO_010081: YDR045C
subclass of: SO_0000673
so part of: YDR045C
location: complement(<547978..>548310)
location: region:547978-548310:-1
so has part: feature:547978-548310:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:547978-548310:-1:exon

YDR045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPC11
locus tag: YDR045C
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793|PMID:9869639]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793|PMID:9869639]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
experiment: EXISTENCE:mutant phenotype:GO:0001056 RNA polymerase III activity [PMID:9869639]
experiment: EXISTENCE:mutant phenotype:GO:0006386 termination of RNA polymerase III transcription [PMID:9869639]
experiment: EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:9869639]
note: RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
codon start: 1
product: DNA-directed RNA polymerase III core subunit RPC11
translation: MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEIYDRKKLPRKEVDDVLGGGWDNVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCGHRWKEN
SIO_010081: YDR045C
subclass of: SO_0000673
so part of: YDR045C
location: complement(547978..548310)
location: region:547978-548310:-1
so has part: feature:547978-548310:-1:exon

NP_010330.1
type: Protein
SIO_000068: ncbiprotein

S000002452
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:547978-548310:-1:exon

YDR046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAP1
gene: BAP3
locus tag: YDR046C
gene synonym: PAP1
so part of: sequence
location: complement(<548762..>550576)
location: region:548762-550576:-1
so has part: feature:548762-550576:-1:exon
subclass of: SO_0000010

851616
type: Gene
SIO_000068: ncbigene

position:548762:-1
position: 548762
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:550576:-1
position: 550576
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:548762-550576:-1:exon

YDR046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAP1
gene: BAP3
locus tag: YDR046C
gene synonym: PAP1
product: amino acid transporter BAP3
transcript id: NM_001180354.3
SIO_010081: YDR046C
subclass of: SO_0000673
so part of: YDR046C
location: complement(<548762..>550576)
location: region:548762-550576:-1
so has part: feature:548762-550576:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548762-550576:-1:exon

YDR046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAP1
gene: BAP3
locus tag: YDR046C
gene synonym: PAP1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]
note: Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
codon start: 1
product: amino acid transporter BAP3
translation: MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC
SIO_010081: YDR046C
subclass of: SO_0000673
so part of: YDR046C
location: complement(548762..550576)
location: region:548762-550576:-1
so has part: feature:548762-550576:-1:exon

NP_010331.3
type: Protein
SIO_000068: ncbiprotein

S000002453
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548762-550576:-1:exon

YDR047W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEM6
gene: HEM12
locus tag: YDR047W
gene synonym: HEM6
so part of: sequence
location: <551860..>552948
location: region:551860-552948:1
so has part: feature:551860-552948:1:exon
subclass of: SO_0000010

851617
type: Gene
SIO_000068: ncbigene

position:551860:1
position: 551860
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:552948:1
position: 552948
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551860-552948:1:exon

YDR047W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEM6
gene: HEM12
locus tag: YDR047W
gene synonym: HEM6
product: uroporphyrinogen decarboxylase HEM12
transcript id: NM_001180355.3
SIO_010081: YDR047W
subclass of: SO_0000673
so part of: YDR047W
location: <551860..>552948
location: region:551860-552948:1
so has part: feature:551860-552948:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551860-552948:1:exon

YDR047W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEM6
gene: HEM12
locus tag: YDR047W
gene synonym: HEM6
EC number: 4.1.1.37
experiment: EXISTENCE:direct assay:GO:0004853 uroporphyrinogen decarboxylase activity [PMID:2180703]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004853 uroporphyrinogen decarboxylase activity [PMID:7035824]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:1471989|PMID:14559249|PMID:7035824]
note: Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
codon start: 1
product: uroporphyrinogen decarboxylase HEM12
translation: MGNFPAPKNDLILRAAKGEKVERPPCWIMRQAGRYLPEYHEVKNNRDFFQTCRDAEIASEITIQPVRRYRGLIDAAIIFSDILVIPQAMGMRVEMLEGKGPHFPEPLRNPEDLQTVLDYKVDVLKELDWAFKAITMTRIKLDGEVPLFGFCGGPWTLMVYMTEGGGSRLFRFAKQWINMYPELSHKLLQKITDVAVEFLSQQVVAGAQILQVFESWGGELSSVDFDEFSLPYLRQIAERVPKRLQELGIMEQIPMIVFAKGSWYALDKLCCSGFDVVSLDWSWDPREAVKINKNRVTLQGNLDPGVMYGSKEVITKKVKQMIEAFGGGKSRYIVNFGHGTHPFMDPDVIKFFLEECHRIGSK
SIO_010081: YDR047W
subclass of: SO_0000673
so part of: YDR047W
location: 551860..552948
location: region:551860-552948:1
so has part: feature:551860-552948:1:exon

NP_010332.3
type: Protein
SIO_000068: ncbiprotein

S000002454
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551860-552948:1:exon

YDR049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VMS1
locus tag: YDR049W
so part of: sequence
location: <553254..>555152
location: region:553254-555152:1
so has part: feature:553254-555152:1:exon
subclass of: SO_0000010

851618
type: Gene
SIO_000068: ncbigene

position:553254:1
position: 553254
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:555152:1
position: 555152
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:553254-555152:1:exon

YDR049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VMS1
locus tag: YDR049W
product: Vms1p
transcript id: NM_001180357.1
SIO_010081: YDR049W
subclass of: SO_0000673
so part of: YDR049W
location: <553254..>555152
location: region:553254-555152:1
so has part: feature:553254-555152:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:553254-555152:1:exon

YDR049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VMS1
locus tag: YDR049W
experiment: EXISTENCE:direct assay:GO:0004045 aminoacyl-tRNA hydrolase activity [PMID:29632312]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:21070972|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:21148305]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:21070972]
experiment: EXISTENCE:direct assay:GO:0005840 ribosome [PMID:29632312]
experiment: EXISTENCE:direct assay:GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex [PMID:21070972]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:21148305]
experiment: EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:22718752]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]
note: Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, component of a Cdc48p-complex; involved in protein quality control; exhibits cytosolic and ER-membrane localization; contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; translocates to mitochondria under oxidative stress and forms a complex with Cdc48p and Npl4p that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)
codon start: 1
product: Vms1p
translation: MNSQKASKMTGSLKKNDLYIFDLSEQLLNSLKLMSFDSTLREVEVEKTSDNDRNKESGDLQIARKKVTSNVMRCSVCQMSFDSRNEQKAHYQTDYHLMNVKRNLRGLDILSVEEFDALISKEHGIKSEDENSGGEQTSSDHEESEEASDRDPDLQTNNYMETIIENDLQKLGFQKDESDAISHINTQSPYIYFKSKYLQKNEVLAIYKSLFNKRSLSNPNEALTFWNSQENPMAISALFMVGGGHFAGAIVSHQRLNVKGNAHKKDETLIEQAVNFLEHKTFHRYTTRRKQGGSQSAMDNAKGKANSAGSALRRYNESALKTDIQGVLKDWEPYLSKCDNIFIRARNVSDKKIFTDNTVLNKGDERIKSFPFTTNRPTVLELKKAWCELSYLKILPKPEPLAVKETVQKLEVSNKKDEFKEKQEPLLEEIQTEEIISLLKKGRAPLLISFLKKNKLDGNFRLKPESKYSLTPTMLHYASQQGMKQMALILLSNIKCDPTIKNRLGRTAWDLNRNDDVRHAFQIARYNLGESFTNWDETHIGQPLSREQVDEINEKKKAIENEKAEKLIKLELEAAKEKQRFAKDAERGPGKKLTNIPSIQQQNLNSLTDEQRRRLMREQRARAAEERMKKKY
SIO_010081: YDR049W
subclass of: SO_0000673
so part of: YDR049W
location: 553254..555152
location: region:553254-555152:1
so has part: feature:553254-555152:1:exon

NP_010334.1
type: Protein
SIO_000068: ncbiprotein

S000002456
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:553254-555152:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS418; Autonomously Replicating Sequence
so part of: sequence
location: 555240..555404
location: region:555240-555404:1
so has part: feature:555240-555404:1:region

S000118435
type: SGD
SIO_000068: sgd

position:555240:1
position: 555240
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:555404:1
position: 555404
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:555240-555404:1:region

YDR050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPI1
locus tag: YDR050C
so part of: sequence
location: complement(<555726..>556472)
location: region:555726-556472:-1
so has part: feature:555726-556472:-1:exon
subclass of: SO_0000010

851620
type: Gene
SIO_000068: ncbigene

position:555726:-1
position: 555726
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:556472:-1
position: 556472
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:555726-556472:-1:exon

YDR050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPI1
locus tag: YDR050C
product: triose-phosphate isomerase TPI1
transcript id: NM_001180358.1
SIO_010081: YDR050C
subclass of: SO_0000673
so part of: YDR050C
location: complement(<555726..>556472)
location: region:555726-556472:-1
so has part: feature:555726-556472:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:555726-556472:-1:exon

YDR050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPI1
locus tag: YDR050C
EC number: 5.3.1.1
experiment: EXISTENCE:direct assay:GO:0004807 triose-phosphate isomerase activity [PMID:236471]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:27385335|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:11329176]
note: Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant
codon start: 1
product: triose-phosphate isomerase TPI1
translation: MARTFFVGGNFKLNGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPEFVDIINSRN
SIO_010081: YDR050C
subclass of: SO_0000673
so part of: YDR050C
location: complement(555726..556472)
location: region:555726-556472:-1
so has part: feature:555726-556472:-1:exon

NP_010335.1
type: Protein
SIO_000068: ncbiprotein

S000002457
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:555726-556472:-1:exon

YDR051C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DET1
locus tag: YDR051C
so part of: sequence
location: complement(<557056..>558060)
location: region:557056-558060:-1
so has part: feature:557056-558060:-1:exon
subclass of: SO_0000010

851621
type: Gene
SIO_000068: ncbigene

position:557056:-1
position: 557056
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:558060:-1
position: 558060
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557056-558060:-1:exon

YDR051C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DET1
locus tag: YDR051C
product: acid phosphatase DET1
transcript id: NM_001180359.3
SIO_010081: YDR051C
subclass of: SO_0000673
so part of: YDR051C
location: complement(<557056..>558060)
location: region:557056-558060:-1
so has part: feature:557056-558060:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557056-558060:-1:exon

YDR051C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DET1
locus tag: YDR051C
experiment: EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:19753119]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:19060182]
note: Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
codon start: 1
product: acid phosphatase DET1
translation: MCEENVHVSEDVAGSHGSFTNARPRLIVLIRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQAGIDLLRVLNVDDHNLVEDLAKKYIKDESSRRTLPLKDYTRLSREKDTNIVFYTSPYRRARETLKGILDVIDEYNELNSGVRICEDMRYDPHGKQKHAFWPRGLNNTGGVYENNEDNICEGKPGKCYLQYRVKDEPRIREQDFGNFQKINSMQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHDRQERRPRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLRTVLPKWTDCEGDLTT
SIO_010081: YDR051C
subclass of: SO_0000673
so part of: YDR051C
location: complement(557056..558060)
location: region:557056-558060:-1
so has part: feature:557056-558060:-1:exon

NP_010336.3
type: Protein
SIO_000068: ncbiprotein

S000002458
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557056-558060:-1:exon

YDR052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DNA52
alternative label: LSD7
gene: DBF4
locus tag: YDR052C
gene synonym: DNA52; LSD7
so part of: sequence
location: complement(<558511..>560625)
location: region:558511-560625:-1
so has part: feature:558511-560625:-1:exon
subclass of: SO_0000010

851623
type: Gene
SIO_000068: ncbigene

position:558511:-1
position: 558511
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560625:-1
position: 560625
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:558511-560625:-1:exon

YDR052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DNA52
alternative label: LSD7
gene: DBF4
locus tag: YDR052C
gene synonym: DNA52; LSD7
product: protein serine/threonine kinase activating protein DBF4
transcript id: NM_001180360.3
SIO_010081: YDR052C
subclass of: SO_0000673
so part of: YDR052C
location: complement(<558511..>560625)
location: region:558511-560625:-1
so has part: feature:558511-560625:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:558511-560625:-1:exon

YDR052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DNA52
alternative label: LSD7
gene: DBF4
locus tag: YDR052C
gene synonym: DNA52; LSD7
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10508166]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:8066465]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0031431 Dbf4-dependent protein kinase complex [PMID:19692334]
experiment: EXISTENCE:direct assay:GO:0045860 positive regulation of protein kinase activity [PMID:19692334]
experiment: EXISTENCE:genetic interaction:GO:0001100 negative regulation of exit from mitosis [PMID:19478884]
experiment: EXISTENCE:genetic interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]
experiment: EXISTENCE:genetic interaction:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:18372119]
experiment: EXISTENCE:genetic interaction:GO:0043539 protein serine/threonine kinase activator activity [PMID:8474449]
experiment: EXISTENCE:genetic interaction:GO:0071902 positive regulation of protein serine/threonine kinase activity [PMID:8474449]
experiment: EXISTENCE:genetic interaction:GO:1903468 positive regulation of DNA replication initiation [PMID:9407029]
experiment: EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:19478884]
experiment: EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:16319063]
experiment: EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:8474449]
experiment: EXISTENCE:mutant phenotype:GO:0060903 positive regulation of meiosis I [PMID:16319063]
experiment: EXISTENCE:mutant phenotype:GO:0071902 positive regulation of protein serine/threonine kinase activity [PMID:8474449]
experiment: EXISTENCE:physical interaction:GO:0006270 DNA replication initiation [PMID:8474449]
experiment: EXISTENCE:physical interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]
note: Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation
codon start: 1
product: protein serine/threonine kinase activating protein DBF4
translation: MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAGHLNVFSNDNNCNNNNTTESFPKKRSLERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDTDILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHNEKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQTWAPIITLEWKPQELTNLDELPYPILKIGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADTLLNTSSVNDQTKNLIFIPHTCNDSTKSFKKWMQEKAKNFEKTELKKTDDSAVQDVRNEHADQTDEKNSILLNETETKEPPLKEEKENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDLCTLKTKSRQAFEIKASGAHQSNDVATSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQTNGNNKNYTATIATTAETSKENRHRLDFNALKKDEAPSKETGKDSAVHLETNRKPQNFPKVATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGYCENCRVKYESLEQHIVSEKHLSFAENDLNFEAIDSLIENLRFQI
SIO_010081: YDR052C
subclass of: SO_0000673
so part of: YDR052C
location: complement(558511..560625)
location: region:558511-560625:-1
so has part: feature:558511-560625:-1:exon

NP_010337.3
type: Protein
SIO_000068: ncbiprotein

S000002459
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:558511-560625:-1:exon

YDR054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DNA6
alternative label: UBC3
gene: CDC34
locus tag: YDR054C
gene synonym: DNA6; UBC3
so part of: sequence
location: complement(<561440..>562327)
location: region:561440-562327:-1
so has part: feature:561440-562327:-1:exon
subclass of: SO_0000010

851624
type: Gene
SIO_000068: ncbigene

position:561440:-1
position: 561440
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:562327:-1
position: 562327
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561440-562327:-1:exon

YDR054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DNA6
alternative label: UBC3
gene: CDC34
locus tag: YDR054C
gene synonym: DNA6; UBC3
product: SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
transcript id: NM_001180362.1
SIO_010081: YDR054C
subclass of: SO_0000673
so part of: YDR054C
location: complement(<561440..>562327)
location: region:561440-562327:-1
so has part: feature:561440-562327:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:561440-562327:-1:exon

YDR054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DNA6
alternative label: UBC3
gene: CDC34
locus tag: YDR054C
gene synonym: DNA6; UBC3
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:1848239]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:2842867|PMID:9346239]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155|PMID:8164658]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238]
experiment: EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]
experiment: EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:8383676]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:9346238]
experiment: EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:7954792|PMID:9736614]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:2842867]
experiment: EXISTENCE:mutant phenotype:GO:0019005 SCF ubiquitin ligase complex [PMID:9736614]
experiment: EXISTENCE:mutant phenotype:GO:0051865 protein autoubiquitination [PMID:8383676]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238]
note: Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant
codon start: 1
product: SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
translation: MSSRKSTASSLLLRQYRELTDPKKAIPSFHIELEDDSNIFTWNIGVMVLNEDSIYHGGFFKAQMRFPEDFPFSPPQFRFTPAIYHPNVYRDGRLCISILHQSGDPMTDEPDAETWSPVQTVESVLISIVSLLEDPNINSPANVDAAVDYRKNPEQYKQRVKMEVERSKQDIPKGFIMPTSESAYISQSKLDEPESNKDMADNFWYDSDLDDDENGSVILQDDDYDDGNNHIPFEDDDVYNYNDNDDDDERIEFEDDDDDDDDSIDNDSVMDRKQPHKAEDESEDVEDVERVSKKI
SIO_010081: YDR054C
subclass of: SO_0000673
so part of: YDR054C
location: complement(561440..562327)
location: region:561440-562327:-1
so has part: feature:561440-562327:-1:exon

NP_010339.1
type: Protein
SIO_000068: ncbiprotein

S000002461
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:561440-562327:-1:exon

YDR055W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HPF2
gene: PST1
locus tag: YDR055W
gene synonym: HPF2
so part of: sequence
location: <563527..>564861
location: region:563527-564861:1
so has part: feature:563527-564861:1:exon
subclass of: SO_0000010

851625
type: Gene
SIO_000068: ncbigene

position:563527:1
position: 563527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:564861:1
position: 564861
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:563527-564861:1:exon

YDR055W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HPF2
gene: PST1
locus tag: YDR055W
gene synonym: HPF2
product: Pst1p
transcript id: NM_001180363.1
SIO_010081: YDR055W
subclass of: SO_0000673
so part of: YDR055W
location: <563527..>564861
location: region:563527-564861:1
so has part: feature:563527-564861:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:563527-564861:1:exon

YDR055W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HPF2
gene: PST1
locus tag: YDR055W
gene synonym: HPF2
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15583168]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15583168]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15583168]
note: Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication
codon start: 1
product: Pst1p
translation: MQLHSLIASTALLITSALAATSSSSSIPSSCTISSHATATAQSDLDKYSRCDTLVGNLTIGGGLKTGALANVKEINGSLTIFNATNLTSFAADSLESITDSLNLQSLTILTSASFGSLQSVDSIKLITLPAISSFTSNIKSANNIYISDTSLQSVDGFSALKKVNVFNVNNNKKLTSIKSPVETVSDSLQFSFNGNQTKITFDDLVWANNISLTDVHSVSFANLQKINSSLGFINNSISSLNFTKLNTIGQTFSIVSNDYLKNLSFSNLSTIGGALVVANNTGLQKIGGLDNLTTIGGTLEVVGNFTSLNLDSLKSVKGGADVESKSSNFSCNALKALQKKGGIKGESFVCKNGASSTSVKLSSTSKSQSSQTTAKVSKSSSKAEEKKFTSGDIKAAASASSVSSSGASSSSSKSSKGNAAIMAPIGQTTPLVGLLTAIIMSIM
SIO_010081: YDR055W
subclass of: SO_0000673
so part of: YDR055W
location: 563527..564861
location: region:563527-564861:1
so has part: feature:563527-564861:1:exon

NP_010340.1
type: Protein
SIO_000068: ncbiprotein

S000002462
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:563527-564861:1:exon

YDR056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMC10
locus tag: YDR056C
so part of: sequence
location: complement(<565023..>565640)
location: region:565023-565640:-1
so has part: feature:565023-565640:-1:exon
subclass of: SO_0000010

851626
type: Gene
SIO_000068: ncbigene

position:565023:-1
position: 565023
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:565640:-1
position: 565640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:565023-565640:-1:exon

YDR056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMC10
locus tag: YDR056C
product: Emc10p
transcript id: NM_001180364.3
SIO_010081: YDR056C
subclass of: SO_0000673
so part of: YDR056C
location: complement(<565023..>565640)
location: region:565023-565640:-1
so has part: feature:565023-565640:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:565023-565640:-1:exon

YDR056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMC10
locus tag: YDR056C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]
note: hypothetical protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein
codon start: 1
product: Emc10p
translation: MLVRLLRVILLASMVFCADILQLSYSDDAKDAIPLGTFEIDSTSDGNVTVTTVNIQDVEVSGEYCLNAQIEGKLDMPCFSYMKLRTPLKYDLIVDVDEDNEVKQVSLSYDETNDAITATVRYPEAGPTAPVTKLKKKTKTYADKKASKNKDGSTAQFEEDEEVKEVSWFQKNWKMLLLGLLIYNFVAGSAKKQQQGGAGADQKTE
SIO_010081: YDR056C
subclass of: SO_0000673
so part of: YDR056C
location: complement(565023..565640)
location: region:565023-565640:-1
so has part: feature:565023-565640:-1:exon

NP_010341.3
type: Protein
SIO_000068: ncbiprotein

S000002463
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:565023-565640:-1:exon

YDR057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YOS9
locus tag: YDR057W
so part of: sequence
location: <565927..>567555
location: region:565927-567555:1
so has part: feature:565927-567555:1:exon
subclass of: SO_0000010

851627
type: Gene
SIO_000068: ncbigene

position:565927:1
position: 565927
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:567555:1
position: 567555
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:565927-567555:1:exon

YDR057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YOS9
locus tag: YDR057W
product: Yos9p
transcript id: NM_001180365.3
SIO_010081: YDR057W
subclass of: SO_0000673
so part of: YDR057W
location: <565927..>567555
location: region:565927-567555:1
so has part: feature:565927-567555:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:565927-567555:1:exon

YDR057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YOS9
locus tag: YDR057W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:16168371]
experiment: EXISTENCE:direct assay:GO:0034099 luminal surveillance complex [PMID:16873065]
experiment: EXISTENCE:direct assay:GO:0070492 oligosaccharide binding [PMID:19111666]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:16168370|PMID:16168371|PMID:16168372|PMID:22298424]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:22298424]
experiment: EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]
experiment: EXISTENCE:mutant phenotype:GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway [PMID:19124653]
experiment: EXISTENCE:physical interaction:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]
note: ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
codon start: 1
product: Yos9p
translation: MQAKIIYALSAISALIPLGSSLLAPIEDPIVSNKYLISYIDEDDWSDRILQNQSVMNSGYIVNMGDDLECFIQNASTQLNDVLEDSNEHSNSEKTALLTKTLNQGVKTIFDKLNERCIFYQAGFWIYEYCPGIEFVQFHGRVNTKTGEIVNRDESLVYRLGKPKANVEEREFELLYDDVGYYISEIIGSGDICDVTGAERMVEIQYVCGGSNSGPSTIQWVRETKICVYEAQVTIPELCNLELLAKNEDQKNASPILCRMPAKSKIGSNSIDLITKYEPIFLGSGIYFLRPFNTDERDKLMVTDNAMSNWDEITETYYQKFGNAINKMLSLRLVSLPNGHILQPGDSCVWLAEVVDMKDRFQTTLSLNILNSQRAEIFFNKTFTFNEDNGNFLSYKIGDHGESTELGQITHSNKADINTAEIRSDEYLINTDNELFLRISKEIAEVKELLNEIVSPHEMEVIFENMRNQPNNDFELALMNKLKSSLNDDNKVEQINNARMDDDESTSHTTRDIGEAGSQTTGNTESEVTNVAAGVFIEHDEL
SIO_010081: YDR057W
subclass of: SO_0000673
so part of: YDR057W
location: 565927..567555
location: region:565927-567555:1
so has part: feature:565927-567555:1:exon

NP_010342.3
type: Protein
SIO_000068: ncbiprotein

S000002464
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:565927-567555:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS419; Autonomously Replicating Sequence
so part of: sequence
location: 567610..567685
location: region:567610-567685:1
so has part: feature:567610-567685:1:region

S000118436
type: SGD
SIO_000068: sgd

position:567610:1
position: 567610
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:567685:1
position: 567685
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:567610-567685:1:region

YDR058C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TGL2
locus tag: YDR058C
so part of: sequence
location: complement(<567723..>568703)
location: region:567723-568703:-1
so has part: feature:567723-568703:-1:exon
subclass of: SO_0000010

851628
type: Gene
SIO_000068: ncbigene

position:567723:-1
position: 567723
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:568703:-1
position: 568703
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:567723-568703:-1:exon

YDR058C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TGL2
locus tag: YDR058C
product: triglyceride lipase
transcript id: NM_001180366.1
SIO_010081: YDR058C
subclass of: SO_0000673
so part of: YDR058C
location: complement(<567723..>568703)
location: region:567723-568703:-1
so has part: feature:567723-568703:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:567723-568703:-1:exon

YDR058C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TGL2
locus tag: YDR058C
EC number: 3.1.1.3
experiment: EXISTENCE:direct assay:GO:0004806 triglyceride lipase activity [PMID:9544243]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19959834]
experiment: EXISTENCE:mutant phenotype:GO:0004806 triglyceride lipase activity [PMID:9544243]
experiment: EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:19959834]
note: Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli
codon start: 1
product: triglyceride lipase
translation: MKNDNKANDIIIDSVKVPDSYKPPKNPIVFCHGLSGFDKLILIPSVFHLTNLISNSIVHNMAENFMQDDEDKSDNKYTNLLEIEYWIGVKKFLQSKGCTVITTKVPGFGSIEERAMALDAQLQKEVKKIESKDKRHSLNLIAHSMGGLDCRYLICNIKNRNYDILSLTTISTPHRGSEMADYVVDLFENLNALRVSQKILPICFYQLTTAYMKYFNLVTPNSPKVSYFSYGCSFVPKWYNVFCTPWKIVYERSKGCPNDGLVTINSSKWGEYRGTLKDMDHLDVINWKNKLQDDWSKFFRTTTVGEKVDILNFYLKITDDLARKGF
SIO_010081: YDR058C
subclass of: SO_0000673
so part of: YDR058C
location: complement(567723..568703)
location: region:567723-568703:-1
so has part: feature:567723-568703:-1:exon

NP_010343.1
type: Protein
SIO_000068: ncbiprotein

S000002465
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:567723-568703:-1:exon

YNCD0011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0011W
so part of: sequence
location: 568882..568953
location: region:568882-568953:1
so has part: feature:568882-568953:1:exon
subclass of: SO_0000663

851629
type: Gene
SIO_000068: ncbigene

position:568882:1
position: 568882
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:568953:1
position: 568953
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568882-568953:1:exon

YNCD0011W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0011W
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCD0011W
subclass of: SO_0000673
so part of: YNCD0011W
location: 568882..568953
location: region:568882-568953:1
so has part: feature:568882-568953:1:exon

S000006709
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568882-568953:1:exon

YNCD0012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0012W
so part of: sequence
location: 568964..569035
location: region:568964-569035:1
so has part: feature:568964-569035:1:exon
subclass of: SO_0000663

851630
type: Gene
SIO_000068: ncbigene

position:568964:1
position: 568964
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:569035:1
position: 569035
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568964-569035:1:exon

YNCD0012W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0012W
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCD0012W
subclass of: SO_0000673
so part of: YNCD0012W
location: 568964..569035
location: region:568964-569035:1
so has part: feature:568964-569035:1:exon

S000006531
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568964-569035:1:exon

YDR059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBC5
locus tag: YDR059C
so part of: sequence
location: complement(<569234..>569770)
location: region:569234-569770:-1
so has part: feature:569234-569770:-1:exon
subclass of: SO_0000010

851631
type: Gene
SIO_000068: ncbigene

position:569234:-1
position: 569234
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:569770:-1
position: 569770
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:569234-569770:-1:exon

YDR059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBC5
locus tag: YDR059C
product: E2 ubiquitin-conjugating protein UBC5
transcript id: NM_001180367.1
SIO_010081: YDR059C
subclass of: SO_0000673
so part of: YDR059C
location: complement(join(<569234..569633,569724..>569770))
location: region:569234-569770:-1
so has part: feature:569724-569770:-1:exon
so has part: feature:569234-569633:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:569724-569770:-1:exon

position:569724:-1
position: 569724
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:569234-569633:-1:exon

position:569633:-1
position: 569633
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDR059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBC5
locus tag: YDR059C
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:2154373]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:2154373]
experiment: EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:10848595]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]
note: Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
codon start: 1
product: E2 ubiquitin-conjugating protein UBC5
translation: MSSSKRIAKELSDLGRDPPASCSAGPVGDDLYHWQASIMGPSDSPYAGGVFFLSIHFPTDYPFKPPKVNFTTKIYHPNINSSGNICLDILKDQWSPALTLSKVLLSICSLLTDANPDDPLVPEIAQIYKTDKAKYEATAKEWTKKYAV
SIO_010081: YDR059C
subclass of: SO_0000673
so part of: YDR059C
location: complement(join(569234..569633,569724..569770))
location: region:569234-569770:-1
so has part: feature:569724-569770:-1:exon
so has part: feature:569234-569633:-1:exon

NP_010344.1
type: Protein
SIO_000068: ncbiprotein

S000002466
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:569724-569770:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:569234-569633:-1:exon

YDR060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NOC1
gene: MAK21
locus tag: YDR060W
gene synonym: NOC1
so part of: sequence
location: <570649..>573726
location: region:570649-573726:1
so has part: feature:570649-573726:1:exon
subclass of: SO_0000010

851632
type: Gene
SIO_000068: ncbigene

position:570649:1
position: 570649
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:573726:1
position: 573726
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:570649-573726:1:exon

YDR060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NOC1
gene: MAK21
locus tag: YDR060W
gene synonym: NOC1
product: RNA-binding ribosome biosynthesis protein MAK21
transcript id: NM_001180368.3
SIO_010081: YDR060W
subclass of: SO_0000673
so part of: YDR060W
location: <570649..>573726
location: region:570649-573726:1
so has part: feature:570649-573726:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:570649-573726:1:exon

YDR060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NOC1
gene: MAK21
locus tag: YDR060W
gene synonym: NOC1
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11371346]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23209026]
experiment: EXISTENCE:direct assay:GO:0030690 Noc1p-Noc2p complex [PMID:11371346]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:9786894]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:23209026|PMID:11371346]
note: Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
codon start: 1
product: RNA-binding ribosome biosynthesis protein MAK21
translation: MSENNGNPLDLSSLRNKISSKLRDNNSKKAKKTHKGKDVKASSNSKKVNEDIRREALALGASEEDLKLIQGLSDDDDAKSEQEFDAVADEDADDKGFKNDLQNFMKNVGFDQHKLEDVDDDDIEEESTSSKESKIPAQEKEHAQSNIASSTIEKTSQESIDNGSEQEENTVEEANLSSDQEPESESAEKEKKEEKDGGLITQTTIISSDKLIIPYDKPWYEIPLDPQVGQNDDVEELSKEQIEKLFERGKQTLEADNQTYYEEFTKDSSQAKFMSQILSDGTLNDKISAVTLLIQDSPLHNTKSLETLVSYCGKKSRNSALQSLNALKDLFLNGLLPNRKLRYFKNQPGLSMMLNKKTLAIFYFEDYLKKLFFRVLEVLEVLSHDPIIHVRLQILNHVFDLLTNQPEQEFNLLRLGVNKIGDIDSKVSSKASYLLLKLEQAHPNMKSIVIDAIVDIALRPNADYHTTYYSVITLNQTILKRSEDSVANKLVKTYFTLFEKFLINTDKDNTNGVVKSNSKSYEEKRKKNFKKGKHGGKSVKIEKTENEVLDEKNSKLFSALLTGINRAFPFAQIPASVYEVHMETLFKITHSSNFNTSIQALVLINQVTVKAKLNSDRYYRTLYESLFDPRLVNSSKQGIYLNLLYKSLKQDALNVERVEAFVKRILQVCSHWLNVGTITGFFFLLIQLAKTVPQIKNLLTNTPVDYEYESDAEEEQGDKDIKRKEYDGRKRDPKFANAEKSSLWEINNFINHFHPTVKTYANAYVTGETEQIAKPDLGLFTLSHFLDRFVYRSAKQTNTARGTSIMQPLFSGSRVNDSVLVKASDIMHDQGPVNTEDWLTKKVEDIKPEDKFFYQYFTTKKTADGKGKKSNKASNFDSDDEMDENEIWSALVKSRPDVEDDSDDSELDFAEDDFSDSTSDDEPKLDAIDDEDAKSEGSQESDQEEGLDEDIFYSFDGEQDNSDKKRSFAESSEEDESSEEEKEEEENKEVSAKRAKKKQRKNMLKSLPVFASADDYAQYLDQDSD
SIO_010081: YDR060W
subclass of: SO_0000673
so part of: YDR060W
location: 570649..573726
location: region:570649-573726:1
so has part: feature:570649-573726:1:exon

NP_010345.3
type: Protein
SIO_000068: ncbiprotein

S000002467
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:570649-573726:1:exon

YDR061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR061W
so part of: sequence
location: <574164..>575783
location: region:574164-575783:1
so has part: feature:574164-575783:1:exon
subclass of: SO_0000010

851633
type: Gene
SIO_000068: ncbigene

position:574164:1
position: 574164
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:575783:1
position: 575783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574164-575783:1:exon

YDR061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR061W
product: uncharacterized protein
transcript id: NM_001180369.3
SIO_010081: YDR061W
subclass of: SO_0000673
so part of: YDR061W
location: <574164..>575783
location: region:574164-575783:1
so has part: feature:574164-575783:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:574164-575783:1:exon

YDR061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR061W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]
note: Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
codon start: 1
product: uncharacterized protein
translation: MSTNKFVVRITNALFKSSLASNSPPVYPKRIRHFEILPNEKWVIWGPGKGKFLDVLNNKYICEPPLSLRFGFLKESSNILPRIEQVAFKGVMPTAHLSARYEYFKDDYDQTCKQFIFDKASGSNAVSYKVETNNRQINMELYNALVENLNLSSLQDRWVMGLSNGQMRRARLARSILKEPDLLLIDDPFLGLDPAAIATISQFLAKYDSIEVSGGCPIVIGLRYQDTIPAWCTHICCVDEKNGILFEGPIEKLQSKMDETRSRALKELEQLKKASNSKEDISINDLICIHPMYGKKEHEIIKMPHLIELDGLSVSYKGEAVLENLHWKVQPGSKWHIRGDNGSGKSTLLSLLTAEHPQSWNSRVIDNGVPRRTGKTNYFDLNSKIGMSSPELHAIFLKNAGGRLNIRESVATGYHEASSNNYLPIWKRLDKNSQEIVNMYLKYFGLDKDADSVLFEQLSVSDQKLVLFVRSLIKMPQILILDEAFSGMEVEPMMRCHEFLEEWPGTVLVVAHVAEETPKCAHYLRLISPGEYEIGDMEN
SIO_010081: YDR061W
subclass of: SO_0000673
so part of: YDR061W
location: 574164..575783
location: region:574164-575783:1
so has part: feature:574164-575783:1:exon

NP_010346.3
type: Protein
SIO_000068: ncbiprotein

S000002468
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:574164-575783:1:exon

YDR062W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCS1
alternative label: TSC1
gene: LCB2
locus tag: YDR062W
gene synonym: SCS1; TSC1
so part of: sequence
location: <576474..>578159
location: region:576474-578159:1
so has part: feature:576474-578159:1:exon
subclass of: SO_0000010

851634
type: Gene
SIO_000068: ncbigene

position:576474:1
position: 576474
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:578159:1
position: 578159
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:576474-578159:1:exon

YDR062W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCS1
alternative label: TSC1
gene: LCB2
locus tag: YDR062W
gene synonym: SCS1; TSC1
product: serine C-palmitoyltransferase LCB2
transcript id: NM_001180370.1
SIO_010081: YDR062W
subclass of: SO_0000673
so part of: YDR062W
location: <576474..>578159
location: region:576474-578159:1
so has part: feature:576474-578159:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:576474-578159:1:exon

YDR062W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCS1
alternative label: TSC1
gene: LCB2
locus tag: YDR062W
gene synonym: SCS1; TSC1
EC number: 2.3.1.50
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0035339 SPOTS complex [PMID:20182505]
experiment: EXISTENCE:mutant phenotype:GO:0004758 serine C-palmitoyltransferase activity [PMID:1556076]
experiment: EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:1556075|PMID:1556076]
note: Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
codon start: 1
product: serine C-palmitoyltransferase LCB2
translation: MSTPANYTRVPLCEPEELPDDIQKENEYGTLDSPGHLYQVKSRHGKPLPEPVVDTPPYYISLLTYLNYLILIILGHVHDFLGMTFQKNKHLDLLEHDGLAPWFSNFESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYPCMNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDDKYFVN
SIO_010081: YDR062W
subclass of: SO_0000673
so part of: YDR062W
location: 576474..578159
location: region:576474-578159:1
so has part: feature:576474-578159:1:exon

NP_010347.1
type: Protein
SIO_000068: ncbiprotein

S000002469
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:576474-578159:1:exon

YDR063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GMF1
gene: AIM7
locus tag: YDR063W
gene synonym: GMF1
so part of: sequence
location: <578663..>579112
location: region:578663-579112:1
so has part: feature:578663-579112:1:exon
subclass of: SO_0000010

851635
type: Gene
SIO_000068: ncbigene

position:578663:1
position: 578663
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:579112:1
position: 579112
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:578663-579112:1:exon

YDR063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GMF1
gene: AIM7
locus tag: YDR063W
gene synonym: GMF1
product: Aim7p
transcript id: NM_001180371.1
SIO_010081: YDR063W
subclass of: SO_0000673
so part of: YDR063W
location: <578663..>579112
location: region:578663-579112:1
so has part: feature:578663-579112:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:578663-579112:1:exon

YDR063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GMF1
gene: AIM7
locus tag: YDR063W
gene synonym: GMF1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20362448|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:20362448]
experiment: EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:20362448]
experiment: EXISTENCE:direct assay:GO:0071846 actin filament debranching [PMID:20362448]
note: Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss
codon start: 1
product: Aim7p
translation: MSNLYKIGTETRNKIKKFRTSTARTDSIKALSIKIEPKPSYEIIVDEDEQEELDEIEDLSELAEILPDNSPRFVLTAYPTTTKDGFKQTPLVLVYWKPMTVVSQEWKMLYAGALEMIREECGTFKLIEVSSGLEDDSDVEELREQLENC
SIO_010081: YDR063W
subclass of: SO_0000673
so part of: YDR063W
location: 578663..579112
location: region:578663-579112:1
so has part: feature:578663-579112:1:exon

NP_010348.1
type: Protein
SIO_000068: ncbiprotein

S000002470
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:578663-579112:1:exon

YDR064W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS13B
alternative label: RPS13C
gene: RPS13
locus tag: YDR064W
gene synonym: RPS13B; RPS13C
so part of: sequence
location: <579458..>580452
location: region:579458-580452:1
so has part: feature:579458-580452:1:exon
subclass of: SO_0000010

851636
type: Gene
SIO_000068: ncbigene

position:579458:1
position: 579458
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:580452:1
position: 580452
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:579458-580452:1:exon

YDR064W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS13B
alternative label: RPS13C
gene: RPS13
locus tag: YDR064W
gene synonym: RPS13B; RPS13C
product: ribosomal 40S subunit protein S13
transcript id: NM_001180372.3
SIO_010081: YDR064W
subclass of: SO_0000673
so part of: YDR064W
location: join(<579458..579478,580018..>580452)
location: region:579458-580452:1
so has part: feature:579458-579478:1:exon
so has part: feature:580018-580452:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:579458-579478:1:exon

position:579478:1
position: 579478
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:580018-580452:1:exon

position:580018:1
position: 580018
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDR064W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS13B
alternative label: RPS13C
gene: RPS13
locus tag: YDR064W
gene synonym: RPS13B; RPS13C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:2517480|PMID:3533916|PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2517480|PMID:3533916|PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:2517480|PMID:3533916|PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:2517480]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
codon start: 1
product: ribosomal 40S subunit protein S13
translation: MGRMHSAGKGISSSAIPYSRNAPAWFKLSSESVIEQIVKYARKGLTPSQIGVLLRDAHGVTQARVITGNKIMRILKSNGLAPEIPEDLYYLIKKAVSVRKHLERNRKDKDAKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVN
SIO_010081: YDR064W
subclass of: SO_0000673
so part of: YDR064W
location: join(579458..579478,580018..580452)
location: region:579458-580452:1
so has part: feature:579458-579478:1:exon
so has part: feature:580018-580452:1:exon

NP_010349.3
type: Protein
SIO_000068: ncbiprotein

S000002471
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:579458-579478:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:580018-580452:1:exon

YDR065W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MTA2
gene: RRG1
locus tag: YDR065W
gene synonym: MTA2
so part of: sequence
location: <580687..>581784
location: region:580687-581784:1
so has part: feature:580687-581784:1:exon
subclass of: SO_0000010

851637
type: Gene
SIO_000068: ncbigene

position:580687:1
position: 580687
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:581784:1
position: 581784
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:580687-581784:1:exon

YDR065W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MTA2
gene: RRG1
locus tag: YDR065W
gene synonym: MTA2
product: Rrg1p
transcript id: NM_001180373.3
SIO_010081: YDR065W
subclass of: SO_0000673
so part of: YDR065W
location: <580687..>581784
location: region:580687-581784:1
so has part: feature:580687-581784:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:580687-581784:1:exon

YDR065W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MTA2
gene: RRG1
locus tag: YDR065W
gene synonym: MTA2
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:16168084]
experiment: EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]
note: hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; required for vacuolar acidification; localizes to the matrix side of the inner mitochondrial membrane
codon start: 1
product: Rrg1p
translation: MAQNFGKIPSHKSYVLSLYRTVLRNIPKCCHSYAFQYEIKKTLSIQLFKHKHDKSSWSVYTLLNEFSLLNNCLLEGKLQEIKNLMKPLKKMKKQLKTTKILNSLTSLGDVKTNDPEEVRRFHVLSAYIKRKQDLGLLPAYIPKTYQHKLLLPLALNEHACLKLFHIQQKLKNGPPSAGLSYTKEGRNQIWFVRSPINKGRQQSKKLGILIRKERKDSQKNIDNLNFCEINAAWALHEAIWEEYLESKKIIKVNLPKYLEYAANIPKSTKCNPSSQYQKVKEWVDPVREIMFELHSKSFQRVEYFNKYKEKLLKNGGQLAYFDKKSKEMYAKRLTLFRKMSKETLPYVTLFIEGRDLPSVLAKYGF
SIO_010081: YDR065W
subclass of: SO_0000673
so part of: YDR065W
location: 580687..581784
location: region:580687-581784:1
so has part: feature:580687-581784:1:exon

NP_010350.3
type: Protein
SIO_000068: ncbiprotein

S000002472
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:580687-581784:1:exon

YDR066C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTR2
locus tag: YDR066C
so part of: sequence
location: complement(<581908..>582498)
location: region:581908-582498:-1
so has part: feature:581908-582498:-1:exon
subclass of: SO_0000010

851638
type: Gene
SIO_000068: ncbigene

position:581908:-1
position: 581908
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:582498:-1
position: 582498
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:581908-582498:-1:exon

YDR066C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTR2
locus tag: YDR066C
product: putative protein-serine/threonine phosphatase
transcript id: NM_001180374.1
SIO_010081: YDR066C
subclass of: SO_0000673
so part of: YDR066C
location: complement(<581908..>582498)
location: region:581908-582498:-1
so has part: feature:581908-582498:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:581908-582498:-1:exon

YDR066C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTR2
locus tag: YDR066C
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
note: hypothetical protein; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
codon start: 1
product: putative protein-serine/threonine phosphatase
translation: MQIITTTFIQKVILGSHQLHEQLSIVEARMIESAIVSMLTESFCENEQTLKYLARLLSPMSYMDVINARRGKKICGYPLCYKSAAENSSDGFFIHSMYCNNYHSKCSLYLMRQLSQTPLHERRGVHLTSYINLEFDDMYSVSLLEELVGSEVPIDTVKSLITSFKDLEFDDTYKNEPLPLDVYFGQLTTDEETCIE
SIO_010081: YDR066C
subclass of: SO_0000673
so part of: YDR066C
location: complement(581908..582498)
location: region:581908-582498:-1
so has part: feature:581908-582498:-1:exon

NP_010351.1
type: Protein
SIO_000068: ncbiprotein

S000002473
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:581908-582498:-1:exon

YDR067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OCA6
locus tag: YDR067C
so part of: sequence
location: complement(<582791..>583465)
location: region:582791-583465:-1
so has part: feature:582791-583465:-1:exon
subclass of: SO_0000010

851639
type: Gene
SIO_000068: ncbigene

position:582791:-1
position: 582791
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:583465:-1
position: 583465
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:582791-583465:-1:exon

YDR067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OCA6
locus tag: YDR067C
product: protein-tyrosine-phosphatase
transcript id: NM_001180375.1
SIO_010081: YDR067C
subclass of: SO_0000673
so part of: YDR067C
location: complement(<582791..>583465)
location: region:582791-583465:-1
so has part: feature:582791-583465:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:582791-583465:-1:exon

YDR067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OCA6
locus tag: YDR067C
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
codon start: 1
product: protein-tyrosine-phosphatase
translation: MTLVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMVKFCEENNIKTIHIKCQSERKADKTKPKIKRKKKTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNSEIEVDDLDIKDKVPWITVRYIARTATESKDELRVDDANASEKVARVSSVSNSLPKLKFHSM
SIO_010081: YDR067C
subclass of: SO_0000673
so part of: YDR067C
location: complement(582791..583465)
location: region:582791-583465:-1
so has part: feature:582791-583465:-1:exon

NP_010352.1
type: Protein
SIO_000068: ncbiprotein

S000002474
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:582791-583465:-1:exon

YDR068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DOS2
locus tag: YDR068W
so part of: sequence
location: <583713..>584645
location: region:583713-584645:1
so has part: feature:583713-584645:1:exon
subclass of: SO_0000010

851640
type: Gene
SIO_000068: ncbigene

position:583713:1
position: 583713
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:584645:1
position: 584645
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:583713-584645:1:exon

YDR068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DOS2
locus tag: YDR068W
product: Dos2p
transcript id: NM_001180376.3
SIO_010081: YDR068W
subclass of: SO_0000673
so part of: YDR068W
location: <583713..>584645
location: region:583713-584645:1
so has part: feature:583713-584645:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:583713-584645:1:exon

YDR068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DOS2
locus tag: YDR068W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
codon start: 1
product: Dos2p
translation: MEFFYEEQVACIEDDKISNSHTKETGSTENTENNELQSRDDKTNEAFQKLEEEVNKRYEKTTSAFKKLVIEKDDGIEINLPISNETTETAQKYLKKLDENIHSVESLAQSYWSKMKTKNFWSGFSSFDNAAENDSNDKDENSKENEIAVGGNRTEAELRTLSKDKSVYLDNKMDLQLDPFDVDEKTEEICSILQGDKDISKLMNDIVPHKISYKDFWHIYFLQRNKILDKESKRKEILSKKEKETEEKEVEWDDEEEEEDDDKVEAVADNKSKGETKVAVSQEGLKDVSDHVGLANKDESKDDDDDDDWE
SIO_010081: YDR068W
subclass of: SO_0000673
so part of: YDR068W
location: 583713..584645
location: region:583713-584645:1
so has part: feature:583713-584645:1:exon

NP_010353.3
type: Protein
SIO_000068: ncbiprotein

S000002475
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:583713-584645:1:exon

YDR069C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DOS1
alternative label: MUT4
alternative label: NPI2
alternative label: SSV7
alternative label: UBP4
gene: DOA4
locus tag: YDR069C
gene synonym: DOS1; MUT4; NPI2; SSV7; UBP4
so part of: sequence
location: complement(<584939..>587719)
location: region:584939-587719:-1
so has part: feature:584939-587719:-1:exon
subclass of: SO_0000010

851641
type: Gene
SIO_000068: ncbigene

position:584939:-1
position: 584939
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:587719:-1
position: 587719
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:584939-587719:-1:exon

YDR069C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DOS1
alternative label: MUT4
alternative label: NPI2
alternative label: SSV7
alternative label: UBP4
gene: DOA4
locus tag: YDR069C
gene synonym: DOS1; MUT4; NPI2; SSV7; UBP4
product: ubiquitin-specific protease DOA4
transcript id: NM_001180377.3
SIO_010081: YDR069C
subclass of: SO_0000673
so part of: YDR069C
location: complement(<584939..>587719)
location: region:584939-587719:-1
so has part: feature:584939-587719:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:584939-587719:-1:exon

YDR069C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DOS1
alternative label: MUT4
alternative label: NPI2
alternative label: SSV7
alternative label: UBP4
gene: DOA4
locus tag: YDR069C
gene synonym: DOS1; MUT4; NPI2; SSV7; UBP4
EC number: 3.4.19.12
experiment: EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:10069815]
experiment: EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:19410548|PMID:8247125]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:17145966]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0010995 free ubiquitin chain depolymerization [PMID:19410548]
experiment: EXISTENCE:genetic interaction:GO:0070676 intralumenal vesicle formation [PMID:23444383]
experiment: EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:8247125]
experiment: EXISTENCE:mutant phenotype:GO:0006275 regulation of DNA replication [PMID:8657109]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17145966]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9119204]
experiment: EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:19410548]
experiment: EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:17376168]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
note: Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication
codon start: 1
product: ubiquitin-specific protease DOA4
translation: MEQNIISTIRDECIRHRSKYLTIAQLTAIAEAKINEFIITGKAKDQDLSSLLDKCIDILSIYKKNSKDIKNIISCKNKGAMISSNSVMIIQLNYVYYKVIHIIVTTNIPHLSEFAKIKLHKSTSDEGNGNNNNNEFQLMNIYNTLLETLLKDENIAKIKSFIKSSIKQTKLNHEQEECNLMRTGSYITSNQLNSLISSSANSASSQMEILLIDIRSRLEFNKSHIDTKNIICLEPISFKMSYSDHDLEKKSLITSPNSEIKMFQSRNLFKFIILYTDANEYNVKQQSVLLDILVNHSFEKPISDDFTKIFILESGFPGWLKSNYGRQVSSSFPSNNNIKDDSVYINGNTSGLSLQHLPKMSPSIRHSMDDSMKEMLVAPTPLNHLQQQQQQQSDNDHVLKRSSSFKKLFSNYTSPNPKNSNSNLYSISSLSISSSPSPLPLHSPDPVKGNSLPINYPETPHLWKNSETDFMTNQREQLNHNSFAHIAPINTKAITSPSRTATPKLQRFPQTISMNLNMNSNGHSSATSTIQPSCLSLSNNDSLDHTDVTPTSSHNYDLDFAVGLENLGNSCYMNCIIQCILGTHELTQIFLDDSYAKHININSKLGSKGILAKYFARLVHMMYKEQVDGSKKISISPIKFKLACGSVNSLFKTASQQDCQEFCQFLLDGLHEDLNQCGSNPPLKELSQEAEARREKLSLRIASSIEWERFLTTDFSVIVDLFQGQYASRLKCKVCSHTSTTYQPFTVLSIPIPKKNSRNNITIEDCFREFTKCENLEVDEQWLCPHCEKRQPSTKQLTITRLPRNLIVHLKRFDNLLNKNNDFVIYPFLLDLTPFWANDFDGVFPPGVNDDELPIRGQIPPFKYELYGVACHFGTLYGGHYTAYVKKGLKKGWLYFDDTKYKPVKNKADAINSNAYVLFYHRVYGV
SIO_010081: YDR069C
subclass of: SO_0000673
so part of: YDR069C
location: complement(584939..587719)
location: region:584939-587719:-1
so has part: feature:584939-587719:-1:exon

NP_010354.3
type: Protein
SIO_000068: ncbiprotein

S000002476
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:584939-587719:-1:exon

YDR070C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP16
locus tag: YDR070C
so part of: sequence
location: complement(<588098..>588379)
location: region:588098-588379:-1
so has part: feature:588098-588379:-1:exon
subclass of: SO_0000010

851642
type: Gene
SIO_000068: ncbigene

position:588098:-1
position: 588098
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:588379:-1
position: 588379
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:588098-588379:-1:exon

YDR070C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP16
locus tag: YDR070C
product: Fmp16p
transcript id: NM_001180378.1
SIO_010081: YDR070C
subclass of: SO_0000673
so part of: YDR070C
location: complement(<588098..>588379)
location: region:588098-588379:-1
so has part: feature:588098-588379:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:588098-588379:-1:exon

YDR070C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP16
locus tag: YDR070C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
note: hypothetical protein; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
codon start: 1
product: Fmp16p
translation: MLRTTFLRTPRQLMRKSPRASFSIVTRAAFPHLKNNQDEAEKKEQGLFDSNKKRLDTLEHGKNPDYKQPGMEDLKKKGDDARIEQNRPDDGVY
SIO_010081: YDR070C
subclass of: SO_0000673
so part of: YDR070C
location: complement(588098..588379)
location: region:588098-588379:-1
so has part: feature:588098-588379:-1:exon

NP_010355.1
type: Protein
SIO_000068: ncbiprotein

S000002477
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:588098-588379:-1:exon

YDR071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAA1
locus tag: YDR071C
so part of: sequence
location: complement(<588827..>589402)
location: region:588827-589402:-1
so has part: feature:588827-589402:-1:exon
subclass of: SO_0000010

851643
type: Gene
SIO_000068: ncbigene

position:588827:-1
position: 588827
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:589402:-1
position: 589402
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:588827-589402:-1:exon

YDR071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAA1
locus tag: YDR071C
product: polyamine acetyltransferase
transcript id: NM_001180379.1
SIO_010081: YDR071C
subclass of: SO_0000673
so part of: YDR071C
location: complement(<588827..>589402)
location: region:588827-589402:-1
so has part: feature:588827-589402:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:588827-589402:-1:exon

YDR071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAA1
locus tag: YDR071C
experiment: EXISTENCE:direct assay:GO:0004059 aralkylamine N-acetyltransferase activity [PMID:11559708]
experiment: EXISTENCE:direct assay:GO:0004145 diamine N-acetyltransferase activity [PMID:15723835]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004145 diamine N-acetyltransferase activity [PMID:15723835]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:15723835]
note: Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
codon start: 1
product: polyamine acetyltransferase
translation: MASSSSTLPLHMYIRPLIIEDLKQILNLESQGFPPNERASEEIISFRLINCPELCSGLFIREIEGKEVKKETLIGHIMGTKIPHEYITIESMGKLQVESSNHIGIHSVVIKPEYQKKNLATLLLTDYIQKLSNQEIGNKIVLIAHEPLIPFYERVGFKIIAENTNVAKDKNFAEQKWIDMERELIKEEYDN
SIO_010081: YDR071C
subclass of: SO_0000673
so part of: YDR071C
location: complement(588827..589402)
location: region:588827-589402:-1
so has part: feature:588827-589402:-1:exon

NP_010356.1
type: Protein
SIO_000068: ncbiprotein

S000002478
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:588827-589402:-1:exon

YDR072C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KTI6
alternative label: MIC2
alternative label: SYR4
gene: IPT1
locus tag: YDR072C
gene synonym: KTI6; MIC2; SYR4
so part of: sequence
location: complement(<589761..>591344)
location: region:589761-591344:-1
so has part: feature:589761-591344:-1:exon
subclass of: SO_0000010

851644
type: Gene
SIO_000068: ncbigene

position:589761:-1
position: 589761
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:591344:-1
position: 591344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:589761-591344:-1:exon

YDR072C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KTI6
alternative label: MIC2
alternative label: SYR4
gene: IPT1
locus tag: YDR072C
gene synonym: KTI6; MIC2; SYR4
product: inositolphosphotransferase
transcript id: NM_001180380.3
SIO_010081: YDR072C
subclass of: SO_0000673
so part of: YDR072C
location: complement(<589761..>591344)
location: region:589761-591344:-1
so has part: feature:589761-591344:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:589761-591344:-1:exon

YDR072C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KTI6
alternative label: MIC2
alternative label: SYR4
gene: IPT1
locus tag: YDR072C
gene synonym: KTI6; MIC2; SYR4
EC number: 2.7.1.228
experiment: EXISTENCE:direct assay:GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process [PMID:9368028]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:6991492]
experiment: EXISTENCE:direct assay:GO:0016772 transferase activity, transferring phosphorus-containing groups [PMID:9368028]
experiment: EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:20030721]
experiment: EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:15792805]
note: Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
codon start: 1
product: inositolphosphotransferase
translation: MNVIFSLASFVKNMYNASLNQRNLISLPFNFMLNFAPVFIWLSIFKRAGLIPIRLRPDIHSKFAFFADQFLFGDYWHELTVQLPDNTSKLFFWSFISSSAFLLVFLICIPFAIWYYIYYIKHVNYNLLEWFANIFHYPCKRKQRPIQKRFRTIFIPFALPLFTFVILNIDHFFAYQSDANFTKTKDLLAWFSYVILHLTAPILTAVYLYVFQPPGTLKCFSFALGLQNIAGVLTHLLVPMASPWFTHLYGIDDTEHVNYTQEGFAAGLIRVDSHLGTHLNTKGFHMSPIVFGAVPSLHSAIAFQCFLFLVSRSTSLKHRFSNAGGFTMHNNDSSTFKLSEEDSEDEGDNSIPPTIGPNDLEMEPLGTVEPVDISNERSSSPSSSFTVSSNERSTGGGDGSIINSNGNKKPLQFVHLYDEDTNFTNKWIFKIVNDGFIPKFWAILYIILQWWATMYLDHHYRFDLFVGVLYAMTSFIIINWFVLQPKVLKKWIHIRLGDKVDTRNEARTFGMRVFCGTKMEWFFDPLA
SIO_010081: YDR072C
subclass of: SO_0000673
so part of: YDR072C
location: complement(589761..591344)
location: region:589761-591344:-1
so has part: feature:589761-591344:-1:exon

NP_010357.3
type: Protein
SIO_000068: ncbiprotein

S000002479
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:589761-591344:-1:exon

YDR073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNF11
locus tag: YDR073W
so part of: sequence
location: <592439..>592948
location: region:592439-592948:1
so has part: feature:592439-592948:1:exon
subclass of: SO_0000010

851645
type: Gene
SIO_000068: ncbigene

position:592439:1
position: 592439
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592948:1
position: 592948
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:592439-592948:1:exon

YDR073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNF11
locus tag: YDR073W
product: Snf11p
transcript id: NM_001180381.3
SIO_010081: YDR073W
subclass of: SO_0000673
so part of: YDR073W
location: <592439..>592948
location: region:592439-592948:1
so has part: feature:592439-592948:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:592439-592948:1:exon

YDR073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNF11
locus tag: YDR073W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:7623818]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17573544]
note: Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
codon start: 1
product: Snf11p
translation: MSSEIAYSNTNTNTENENRNTGAGVDVNTNANANANATANATANATANATAELNLPTVDEQRQYKVQLLLHINSILLARVIQMNNSLQNNLQNNINNSNNNNIIRIQQLISQFLKRVHANLQCISQINQGVPSAKPLILTPPQLANQQQPPQDILSKLYLLLARVFEIW
SIO_010081: YDR073W
subclass of: SO_0000673
so part of: YDR073W
location: 592439..592948
location: region:592439-592948:1
so has part: feature:592439-592948:1:exon

NP_010358.3
type: Protein
SIO_000068: ncbiprotein

S000002480
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:592439-592948:1:exon

YDR074W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HOG2
alternative label: PFK3
gene: TPS2
locus tag: YDR074W
gene synonym: HOG2; PFK3
so part of: sequence
location: <593893..>596583
location: region:593893-596583:1
so has part: feature:593893-596583:1:exon
subclass of: SO_0000010

851646
type: Gene
SIO_000068: ncbigene

position:593893:1
position: 593893
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:596583:1
position: 596583
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593893-596583:1:exon

YDR074W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HOG2
alternative label: PFK3
gene: TPS2
locus tag: YDR074W
gene synonym: HOG2; PFK3
product: trehalose-phosphatase TPS2
transcript id: NM_001180382.1
SIO_010081: YDR074W
subclass of: SO_0000673
so part of: YDR074W
location: <593893..>596583
location: region:593893-596583:1
so has part: feature:593893-596583:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593893-596583:1:exon

YDR074W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HOG2
alternative label: PFK3
gene: TPS2
locus tag: YDR074W
gene synonym: HOG2; PFK3
EC number: 3.1.3.12
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0004805 trehalose-phosphatase activity [PMID:8444170|PMID:9837904]
experiment: EXISTENCE:mutant phenotype:GO:0005992 trehalose biosynthetic process [PMID:8203161|PMID:8444170]
experiment: EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:32240040]
experiment: EXISTENCE:mutant phenotype:GO:0070413 trehalose metabolism in response to stress [PMID:9837904]
experiment: EXISTENCE:physical interaction:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:9837904]
note: Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in the synthesis of storage carbohydrate trehalose; positive regulator of autophagy involved in the dephosphorylation of Rim15p leading to ATG8 induction; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
codon start: 1
product: trehalose-phosphatase TPS2
translation: MTTTAQDNSPKKRQRIINCVTQLPYKIQLGESNDDWKISATTGNSALFSSLEYLQFDSTEYEQHVVGWTGEITRTERNLFTREAKEKPQDLDDDPLYLTKEQINGLTTTLQDHMKSDKEAKTDTTQTAPVTNNVHPVWLLRKNQSRWRNYAEKVIWPTFHYILNPSNEGEQEKNWWYDYVKFNEAYAQKIGEVYRKGDIIWIHDYYLLLLPQLLRMKFNDESIIIGYFHHAPWPSNEYFRCLPRRKQILDGLVGANRICFQNESFSRHFVSSCKRLLDATAKKSKNSSNSDQYQVSVYGGDVLVDSLPIGVNTTQILKDAFTKDIDSKVLSIKQAYQNKKIIIGRDRLDSVRGVVQKLRAFETFLAMYPEWRDQVVLIQVSSPTANRNSPQTIRLEQQVNELVNSINSEYGNLNFSPVQHYYMRIPKDVYLSLLRVADLCLITSVRDGMNTTALEYVTVKSHMSNFLCYGNPLILSEFSGSSNVLKDAIVVNPWDSVAVAKSINMALKLDKEEKSNLESKLWKEVPTIQDWTNKFLSSLKEQASSNDDMERKMTPALNRPVLLENYKQAKRRLFLFDYDGTLTPIVKDPAAAIPSARLYTILQKLCADPHNQIWIISGRDQKFLNKWLGGKLPQLGLSAEHGCFMKDVSCQDWVNLTEKVDMSWQVRVNEVMEEFTTRTPGSFIERKKVALTWHYRRTVPELGEFHAKELKEKLLSFTDDFDLEVMDGKANIEVRPRFVNKGEIVKRLVWHQHGKPQDMLKGISEKLPKDEMPDFVLCLGDDFTDEDMFRQLNTIETCWKEKYPDQKNQWGNYGFYPVTVGSASKKTVAKAHLTDPQQVLETLGLLVGDVSLFQSAGTVDLDSRGHVKNSESSLKSKLASKAYVMKRSASYTGAKV
SIO_010081: YDR074W
subclass of: SO_0000673
so part of: YDR074W
location: 593893..596583
location: region:593893-596583:1
so has part: feature:593893-596583:1:exon

NP_010359.1
type: Protein
SIO_000068: ncbiprotein

S000002481
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593893-596583:1:exon

YDR075W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPH3
locus tag: YDR075W
so part of: sequence
location: <597156..>598082
location: region:597156-598082:1
so has part: feature:597156-598082:1:exon
subclass of: SO_0000010

851647
type: Gene
SIO_000068: ncbigene

position:597156:1
position: 597156
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:598082:1
position: 598082
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:597156-598082:1:exon

YDR075W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPH3
locus tag: YDR075W
product: phosphoprotein phosphatase PP4 catalytic subunit PPH3
transcript id: NM_001180383.1
SIO_010081: YDR075W
subclass of: SO_0000673
so part of: YDR075W
location: <597156..>598082
location: region:597156-598082:1
so has part: feature:597156-598082:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:597156-598082:1:exon

YDR075W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPH3
locus tag: YDR075W
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:20951350]
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:16299494|PMID:7941742]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030289 protein phosphatase 4 complex [PMID:16299494|PMID:17517611]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:21135129]
experiment: EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:12820961]
experiment: EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:16299494]
experiment: EXISTENCE:mutant phenotype:GO:0030289 protein phosphatase 4 complex [PMID:16299494]
experiment: EXISTENCE:mutant phenotype:GO:0051173 positive regulation of nitrogen compound metabolic process [PMID:10940301]
experiment: EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:20951350]
experiment: EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:24277933]
experiment: EXISTENCE:mutant phenotype:GO:2000002 negative regulation of DNA damage checkpoint [PMID:16299494|PMID:17517611]
experiment: EXISTENCE:mutant phenotype:GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining [PMID:24498054]
note: Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
codon start: 1
product: phosphoprotein phosphatase PP4 catalytic subunit PPH3
translation: MMDLDKIIASLRDGKHIPEETVFRLCLNSQELLMNEGNVTQVDTPVTICGDIHGQLHDLLTLFEKSGGVEKTRYIFLGDFVDRGFYSLESFLLLLCYKLRYPDRITLIRGNHETRQITKVYGFYDEVVRKYGNSNVWRYCCEVFDYLSLGAIINNSIFCVHGGLSPDMTTVDEIRTIDRKQEVPHEGAMCDLLWSDPEDVDTWSLSPRGAGFLFGKREVDQFLEKNNVELIARAHQLVMEGYKEMFDGGLVTVWSAPNYCYRCGNVAAVLKIDDDLNREYTIFEAVQAQNEVGNAIIPTKKSQMDYFL
SIO_010081: YDR075W
subclass of: SO_0000673
so part of: YDR075W
location: 597156..598082
location: region:597156-598082:1
so has part: feature:597156-598082:1:exon

NP_010360.1
type: Protein
SIO_000068: ncbiprotein

S000002482
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:597156-598082:1:exon

YDR076W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD55
locus tag: YDR076W
so part of: sequence
location: <598468..>599688
location: region:598468-599688:1
so has part: feature:598468-599688:1:exon
subclass of: SO_0000010

851648
type: Gene
SIO_000068: ncbigene

position:598468:1
position: 598468
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:599688:1
position: 599688
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:598468-599688:1:exon

YDR076W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD55
locus tag: YDR076W
product: putative DNA-dependent ATPase RAD55
transcript id: NM_001180384.3
SIO_010081: YDR076W
subclass of: SO_0000673
so part of: YDR076W
location: <598468..>599688
location: region:598468-599688:1
so has part: feature:598468-599688:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:598468-599688:1:exon

YDR076W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD55
locus tag: YDR076W
experiment: EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:9159392]
experiment: EXISTENCE:direct assay:GO:0033065 Rad51C-XRCC3 complex [PMID:9159392]
experiment: EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:9679065]
experiment: EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:11459983|PMID:12887906|PMID:14765116]
note: Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
codon start: 1
product: putative DNA-dependent ATPase RAD55
translation: MSLGIPLSQLIVESPKPLSSGITGLDEILNLGFQARSIYEIFGPPGIGKTNFGIQLVCNSLEGIQQSEINDDKILWIETFQEMPINILRERFQKFKIVEENVKRVRITKFGQLLYFFQNLFKLSQSVRYKLVIIDGFSQLVCDHLCTLSKRGGGMIDKTIHELKCRHLILIFTVMTKYTHSTGSTIIVLNDCMNTAFQSNEFESLEEYYEILDDGSNFFVNSNNERRKNNVHILKSALVANIAMGSKDSTWEVFLRDRIGLFRDWNEQVDETVFVKSKRVKASSSQSNEGCTTIKEMRINKRNFENLRIAIVFNLHGEDRKREGRNLKRSRSSDDRNYIVKFDFDKATGQLRDIIDLKPDTANIASFPTLSTSSSSCSQVFNNIDSNDNPLPNAEGKEEIIYDSEG
SIO_010081: YDR076W
subclass of: SO_0000673
so part of: YDR076W
location: 598468..599688
location: region:598468-599688:1
so has part: feature:598468-599688:1:exon

NP_010361.3
type: Protein
SIO_000068: ncbiprotein

S000002483
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:598468-599688:1:exon

YDR077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SED1
locus tag: YDR077W
so part of: sequence
location: <600793..>601809
location: region:600793-601809:1
so has part: feature:600793-601809:1:exon
subclass of: SO_0000010

851649
type: Gene
SIO_000068: ncbigene

position:600793:1
position: 600793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:601809:1
position: 601809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:600793-601809:1:exon

YDR077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SED1
locus tag: YDR077W
product: Sed1p
transcript id: NM_001180385.3
SIO_010081: YDR077W
subclass of: SO_0000673
so part of: YDR077W
location: <600793..>601809
location: region:600793-601809:1
so has part: feature:600793-601809:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:600793-601809:1:exon

YDR077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SED1
locus tag: YDR077W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15351639]
experiment: EXISTENCE:direct assay:GO:0005840 ribosome [PMID:12627396]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9613572]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:15351639]
experiment: EXISTENCE:mutant phenotype:GO:0005199 structural constituent of cell wall [PMID:9642191]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9642191]
note: Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog, SPI1, that arose from the whole genome duplication
codon start: 1
product: Sed1p
translation: MKLSTVLLSAGLASTTLAQFSNSTSASSTDVTSSSSISTSSGSVTITSSEAPESDNGTSTAAPTETSTEAPTTAIPTNGTSTEAPTTAIPTNGTSTEAPTDTTTEAPTTALPTNGTSTEAPTDTTTEAPTTGLPTNGTTSAFPPTTSLPPSNTTTTPPYNPSTDYTTDYTVVTEYTTYCPEPTTFTTNGKTYTVTEPTTLTITDCPCTIEKPTTTSTTEYTVVTEYTTYCPEPTTFTTNGKTYTVTEPTTLTITDCPCTIEKSEAPESSVPVTESKGTTTKETGVTTKQTTANPSLTVSTVVPVSSSASSHSVVINSNGANVVVPGALGLAGVAMLFL
SIO_010081: YDR077W
subclass of: SO_0000673
so part of: YDR077W
location: 600793..601809
location: region:600793-601809:1
so has part: feature:600793-601809:1:exon

NP_010362.3
type: Protein
SIO_000068: ncbiprotein

S000002484
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:600793-601809:1:exon

YDR078C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHU2
locus tag: YDR078C
so part of: sequence
location: complement(<602198..>602869)
location: region:602198-602869:-1
so has part: feature:602198-602869:-1:exon
subclass of: SO_0000010

851650
type: Gene
SIO_000068: ncbigene

position:602198:-1
position: 602198
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:602869:-1
position: 602869
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:602198-602869:-1:exon

YDR078C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHU2
locus tag: YDR078C
product: Shu2p
transcript id: NM_001180386.1
SIO_010081: YDR078C
subclass of: SO_0000673
so part of: YDR078C
location: complement(<602198..>602869)
location: region:602198-602869:-1
so has part: feature:602198-602869:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:602198-602869:-1:exon

YDR078C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHU2
locus tag: YDR078C
experiment: EXISTENCE:curator inference:GO:0070987 error-free translesion synthesis [PMID:19496932]
experiment: EXISTENCE:direct assay:GO:0097196 Shu complex [PMID:23575680]
experiment: EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15654096]
experiment: EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:21372173]
experiment: EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:23575680]
experiment: EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:23575680]
experiment: EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23575680]
experiment: EXISTENCE:physical interaction:GO:0097196 Shu complex [PMID:15654096]
note: Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both
codon start: 1
product: Shu2p
translation: MSKDVIEYSKLFAKLVNTNDDTKLDDTIASFLYYMFPRELFIRAISLLESSDMFIYILDRVHNKEGNEHTSLIDVLVDEFYKGSSNSLLEYRLIVKDTNDGAPPILVDIAHWFCSCEEFCKYFHEALEKTDEKEELHDVLINEVDDHLQFSDDRFAQLDPHSLSKQWYFKFDKVCCSHLLAFSILLRSSINVLKFFTVNSNKVFVIAIDNIDEWLNLHINIVE
SIO_010081: YDR078C
subclass of: SO_0000673
so part of: YDR078C
location: complement(602198..602869)
location: region:602198-602869:-1
so has part: feature:602198-602869:-1:exon

NP_010363.1
type: Protein
SIO_000068: ncbiprotein

S000002485
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:602198-602869:-1:exon

YDR079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PET100
locus tag: YDR079W
so part of: sequence
location: <603064..>603399
location: region:603064-603399:1
so has part: feature:603064-603399:1:exon
subclass of: SO_0000010

851651
type: Gene
SIO_000068: ncbigene

position:603064:1
position: 603064
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:603399:1
position: 603399
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:603064-603399:1:exon

YDR079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PET100
locus tag: YDR079W
product: Pet100p
transcript id: NM_001180387.1
SIO_010081: YDR079W
subclass of: SO_0000673
so part of: YDR079W
location: <603064..>603399
location: region:603064-603399:1
so has part: feature:603064-603399:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:603064-603399:1:exon

YDR079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PET100
locus tag: YDR079W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15507444|PMID:11498004]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:11498004]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:11498004|PMID:15507444]
note: Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
codon start: 1
product: Pet100p
translation: MGLFNNFKFKYTRAQLEIFRFSFCLLAPVAVMYYIGTDTDKKLNVPGFWPDPATLNQIPKEPYEIKAELARMKKERLEKRLRLEKKIQEEFGLDLEEEKEKIKRDLALKKG
SIO_010081: YDR079W
subclass of: SO_0000673
so part of: YDR079W
location: 603064..603399
location: region:603064-603399:1
so has part: feature:603064-603399:1:exon

NP_010364.1
type: Protein
SIO_000068: ncbiprotein

S000002486
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:603064-603399:1:exon

YDR079C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TFB5
locus tag: YDR079C-A
so part of: sequence
location: complement(<603593..>603811)
location: region:603593-603811:-1
so has part: feature:603593-603811:-1:exon
subclass of: SO_0000010

851652
type: Gene
SIO_000068: ncbigene

position:603593:-1
position: 603593
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:603811:-1
position: 603811
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:603593-603811:-1:exon

YDR079C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TFB5
locus tag: YDR079C-A
product: TFIIH complex subunit TFB5
transcript id: NM_001184469.3
SIO_010081: YDR079C-A
subclass of: SO_0000673
so part of: YDR079C-A
location: complement(<603593..>603811)
location: region:603593-603811:-1
so has part: feature:603593-603811:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:603593-603811:-1:exon

YDR079C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TFB5
locus tag: YDR079C-A
experiment: EXISTENCE:curator inference:GO:0000993 RNA polymerase II complex binding [PMID:19818408]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:15220919|PMID:27381459]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]
experiment: EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:30905750]
experiment: EXISTENCE:direct assay:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:19450536|PMID:19679665]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:17215295]
experiment: EXISTENCE:physical interaction:GO:0000439 transcription factor TFIIH core complex [PMID:17215295]
note: Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
codon start: 1
product: TFIIH complex subunit TFB5
translation: MARARKGALVQCDPSIKALILQIDAKMSDIVLEELDDTHLLVNPSKVEFVKHELNRLLSKNIYNPMDEEENQ
SIO_010081: YDR079C-A
subclass of: SO_0000673
so part of: YDR079C-A
location: complement(603593..603811)
location: region:603593-603811:-1
so has part: feature:603593-603811:-1:exon

NP_076886.3
type: Protein
SIO_000068: ncbiprotein

S000007603
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:603593-603811:-1:exon

YDR080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CVT8
alternative label: FET2
alternative label: SVL2
alternative label: VAM2
alternative label: VPL20
gene: VPS41
locus tag: YDR080W
gene synonym: CVT8; FET2; SVL2; VAM2; VPL20
so part of: sequence
location: <604008..>606986
location: region:604008-606986:1
so has part: feature:604008-606986:1:exon
subclass of: SO_0000010

851653
type: Gene
SIO_000068: ncbigene

position:604008:1
position: 604008
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:606986:1
position: 606986
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:604008-606986:1:exon

YDR080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CVT8
alternative label: FET2
alternative label: SVL2
alternative label: VAM2
alternative label: VPL20
gene: VPS41
locus tag: YDR080W
gene synonym: CVT8; FET2; SVL2; VAM2; VPL20
product: Vps41p
transcript id: NM_001180388.3
SIO_010081: YDR080W
subclass of: SO_0000673
so part of: YDR080W
location: <604008..>606986
location: region:604008-606986:1
so has part: feature:604008-606986:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:604008-606986:1:exon

YDR080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CVT8
alternative label: FET2
alternative label: SVL2
alternative label: VAM2
alternative label: VPL20
gene: VPS41
locus tag: YDR080W
gene synonym: CVT8; FET2; SVL2; VAM2; VPL20
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9111041|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]
experiment: EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]
experiment: EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]
experiment: EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:9159129]
experiment: EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9111041]
experiment: EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:9184222]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12730205]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]
experiment: EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]
experiment: EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:18809726|PMID:20604902|PMID:21325627]
note: Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites
codon start: 1
product: Vps41p
translation: MTTDNHQNDSVLDQQSGERTIDESNSISDENNVDNKREDVNVTSPTKSVSCISQAENGVASRTDESTITGSATDAETGDDDDDDDDDDDEDEDDEDEPPLLKYTRISQLPKNFFQRDSISSCLFGDTFFAFGTHSGILHLTTCAFEPIKTIKCHRSSILCINTDGKYFATGSIDGTVIIGSMDDPQNITQYDFKRPINSVALHSNFQASRMFVSGGMAGDVVLSQRNWLGNRIDIVLNKKKKKKTRKDDLSSDMKGPIMGIYTMGDLILWMDDDGITFCDVPTRSQLLNIPFPSRIFNVQDVRPDLFRPHVHFLESDRVVIGWGSNIWLFKVSFTKDSNSIKSGDSNSQSNNMSHFNPTTNIGSLLSSAASSFRGTPDKKVELECHFTVSMLITGLASFKDDQLLCLGFDIDIEEEATIDEDMKEGKNFSKRPENLLAKGNAPELKIVDLFNGDEIYNDEVIMKNYEKLSINDYHLGKHIDKTTPEYYLISSNDAIRVQELSLKDHFDWFMERKQYYKAWKIGKYVIGSEERFSIGLKFLNSLVTKKDWGTLVDHLNIIFEETLNSLDSNSYDVTQNVLKEWADIIEILITSGNIVEIAPLIPKKPALRKSVYDDVLHYFLANDMINKFHEYITKWDLKLFSVEDFEEELETRIEAASEPTASSKEEGSNITYRTELVHLYLKENKYTKAIPHLLKAKDLRALTIIKIQNLLPQYLDQIVDIILLPYKGEISHISKLSIFEIQTIFNKPIDLLFENRHTISVARIYEIFEHDCPKSFKKILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSLLPFLQKHNNYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDELKNPQLAIDFVKNWGDSELWEFMINYSLDKPNFTKAILTCSDETSEIYLKVIRGMSDDLQIDNLQDIIKHIVQENSLSLEVRDNILVIINDETKKFANEFLKIRSQGKLFQVDESDIEINDDLNGVL
SIO_010081: YDR080W
subclass of: SO_0000673
so part of: YDR080W
location: 604008..606986
location: region:604008-606986:1
so has part: feature:604008-606986:1:exon

NP_010365.3
type: Protein
SIO_000068: ncbiprotein

S000002487
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:604008-606986:1:exon

YDR081C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDC2
locus tag: YDR081C
so part of: sequence
location: complement(<607304..>610081)
location: region:607304-610081:-1
so has part: feature:607304-610081:-1:exon
subclass of: SO_0000010

851654
type: Gene
SIO_000068: ncbigene

position:607304:-1
position: 607304
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:610081:-1
position: 610081
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:607304-610081:-1:exon

YDR081C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDC2
locus tag: YDR081C
product: Pdc2p
transcript id: NM_001180389.1
SIO_010081: YDR081C
subclass of: SO_0000673
so part of: YDR081C
location: complement(<607304..>610081)
location: region:607304-610081:-1
so has part: feature:607304-610081:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:607304-610081:-1:exon

YDR081C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDC2
locus tag: YDR081C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:22404710]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:22404710]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19013460]
experiment: EXISTENCE:genetic interaction:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:16850348]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8264540]
experiment: EXISTENCE:mutant phenotype:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:16850348]
experiment: EXISTENCE:mutant phenotype:GO:2001172 positive regulation of glycolytic fermentation to ethanol [PMID:8264540]
note: Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
codon start: 1
product: Pdc2p
translation: MLSIQQRYNICLMAERHPKWTQLELAKWAYETFQLPKIPSQGTISRLLARKSTYMNCKEHEKDANRLRKPNNLLVRKILQEWISQSLWNGIPITSPIIQDTAQAVWHRIPAEHREGNGSFSYKWISNFLSKMDVNISVLDEELPKTPKVWTFEERDVLKAYFSKIPPKDLFTLDEAFLSYNLPLDYAQYEASSIQRRIEVATVMLCSNLDGSEKLKPVVVGKYDSYKSFRNYFPNEPNDPVSQSMLGTKMAKKFDISYHSNRKAWLTSNLFHNWLVRWDKRLVAVNRKIWIVLDDSCCHRIINLRLQNIKLVYTSSNSKFLPFNWGVWDEFKTRYRIQQYQALIDLQNRISKNIQNKNKSERNECIPNGKKCLISFEQSQLTMSNAFKFIKKAWDDIPVDAIKANWKSSGLLPPEMIHLNENVSMAFKKNEVLESVLNRLCDEYYCVKKWEYEMLLDLNIENKNTNFLSTEELVESAIVEPCEPDFDTAPKGNEVHDDNFDVSVFANEDDNNQNHLSMSQASHNPDYNSNHSNNAIENTNNRGSNNNNNNNGSSNNINDNDSSVKYLQQNTVDNSTKTGNPGQPNISSMESQRNSSTTDLVVDGNYDVNFNGLLNDPYNTMKQPGPLDYNVSTLIDKPNLFLSPDLDLSTVGVDMQLPSSEYFSEVFSSAIRNNEKAASDQNKSTDELPSSTAMANSNSITTALLESRNQAQPFDVPHMNGLLSDTSKSGHSVNSSNAISQNSLNNFQHNSASVAEASSPSITPSPVAINSTGAPARSIISAPIDSNSSASSPSALEHLEGAVSGMSPSSTTILSNLQTNINIAKSLSTIMKHAESNEISLTKETINELNFNYLTLLKRIKKTRKQLNSESIKINSKNAQDHLETLLSGAAAAAATSANNLDLPTGGSNLPDSNNLHLPGNTGFF
SIO_010081: YDR081C
subclass of: SO_0000673
so part of: YDR081C
location: complement(607304..610081)
location: region:607304-610081:-1
so has part: feature:607304-610081:-1:exon

NP_010366.1
type: Protein
SIO_000068: ncbiprotein

S000002488
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:607304-610081:-1:exon

YDR082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STN1
locus tag: YDR082W
so part of: sequence
location: <610441..>611925
location: region:610441-611925:1
so has part: feature:610441-611925:1:exon
subclass of: SO_0000010

851655
type: Gene
SIO_000068: ncbigene

position:610441:1
position: 610441
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611925:1
position: 611925
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:610441-611925:1:exon

YDR082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STN1
locus tag: YDR082W
product: Stn1p
transcript id: NM_001180390.1
SIO_010081: YDR082W
subclass of: SO_0000673
so part of: YDR082W
location: <610441..>611925
location: region:610441-611925:1
so has part: feature:610441-611925:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:610441-611925:1:exon

YDR082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STN1
locus tag: YDR082W
experiment: EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17293872]
experiment: EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:31006804]
experiment: EXISTENCE:genetic interaction:GO:0016233 telomere capping [PMID:15132993|PMID:9042864]
experiment: EXISTENCE:genetic interaction:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:17947422]
experiment: EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:9042864|PMID:15132993]
experiment: EXISTENCE:mutant phenotype:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:17947422]
experiment: EXISTENCE:physical interaction:GO:0016233 telomere capping [PMID:15132993|PMID:9042864]
experiment: EXISTENCE:physical interaction:GO:1990879 CST complex [PMID:11230140|PMID:9042864]
note: Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; similar to human Stn1
codon start: 1
product: Stn1p
translation: MDKYGHIAHQEGDVCYYIPRLFKYNSYYSGTEDVRIFVGDLKYRMRVSLQICEKYYDRRLSMLFWKNHPLQQIHLIGCIIGLQFKWIGKQEYIFFQLDDCTSDSSLVGYTSDMRFLTCKVKKDSILSWGLNITDLIGLTLHVYGQASLNYQELQVEYLRLCYSLTEEIDHWKITMNMREQLDTPWSLSDFVIGELFTQEQEWTPETSQIEVVNPDFVGIGYKTPESKRNETTFIEQLQEERLKDELEIISPYNSTDTSNSVHSLSFRFVSSLKDFPETHFLNSGDQIDNGNDEQLKKLEYQSANLPVMIPNRTSAKSNLMLILLGLQMKEISNSDLYKLKEVRSVVTSLASFLFQQQNVGVMKSFDSLEKEAFRDLVNRLVSQGLIGLKDKTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLPYITTNGIVDVFKECLKRTKKQYPEVLKNWWIDLDPKNGMEDQNSGILLHLEYAAAYS
SIO_010081: YDR082W
subclass of: SO_0000673
so part of: YDR082W
location: 610441..611925
location: region:610441-611925:1
so has part: feature:610441-611925:1:exon

NP_010367.1
type: Protein
SIO_000068: ncbiprotein

S000002489
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:610441-611925:1:exon

YDR083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP8
locus tag: YDR083W
so part of: sequence
location: <612073..>613251
location: region:612073-613251:1
so has part: feature:612073-613251:1:exon
subclass of: SO_0000010

851656
type: Gene
SIO_000068: ncbigene

position:612073:1
position: 612073
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:613251:1
position: 613251
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:612073-613251:1:exon

YDR083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP8
locus tag: YDR083W
product: 25S rRNA (adenine645-N1)-methyltransferase
transcript id: NM_001180391.3
SIO_010081: YDR083W
subclass of: SO_0000673
so part of: YDR083W
location: <612073..>613251
location: region:612073-613251:1
so has part: feature:612073-613251:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:612073-613251:1:exon

YDR083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP8
locus tag: YDR083W
EC number: 2.1.1.287
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10864042|PMID:23180764|PMID:22588997]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:22588997]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:10864042]
experiment: EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:23180764]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10864042]
experiment: EXISTENCE:mutant phenotype:GO:0016433 rRNA (adenine) methyltransferase activity [PMID:23180764]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:23180764]
note: Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with gar1 mutation; deletion disrupts telomere maintenance by influencing expression of neighboring gene STN1; mammalian homolog nucleomethylin has been linked to nutrient availability signaling pathways and obesity
codon start: 1
product: 25S rRNA (adenine645-N1)-methyltransferase
translation: MALFNVEGWSIKTKTVAFDNKTNKSSKDKKKNNRKNGKLTREQKLKEETEAELKEQVEDIPSEGSVAKDIPKKNQEKSDQNETSKKRKHDEEAPLMQVKENIEKPTKKQLTPLQQKMMAKLTGSRFRWINEQLYTISSDEALKLIKEQPQLFDEYHDGFRSQVQAWPENPVDVFVDQIRYRCMKPVNAPGGLPGLKDSKEIVIADMGCGEAQLALEINNFFKNYNKKAKKYLKRRHKVHSFDLKKANERITVADIRNVPLPDESCTIVVFCLALMGTNFLDFIKEAYRILAPRGELWIAEIKSRFSDGKGNEFVDALKLMGFFHKKTFDENKMFTRFEFFKPPAEIIEERRQKLERRQKFIEVETEKEELEKKRRKIAEGKWLLKPCIYKRR
SIO_010081: YDR083W
subclass of: SO_0000673
so part of: YDR083W
location: 612073..613251
location: region:612073-613251:1
so has part: feature:612073-613251:1:exon

NP_010368.5
type: Protein
SIO_000068: ncbiprotein

S000002490
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:612073-613251:1:exon

YDR084C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TVP23
locus tag: YDR084C
so part of: sequence
location: complement(<613405..>614004)
location: region:613405-614004:-1
so has part: feature:613405-614004:-1:exon
subclass of: SO_0000010

851657
type: Gene
SIO_000068: ncbigene

position:613405:-1
position: 613405
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:614004:-1
position: 614004
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:613405-614004:-1:exon

YDR084C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TVP23
locus tag: YDR084C
product: Tvp23p
transcript id: NM_001180392.3
SIO_010081: YDR084C
subclass of: SO_0000673
so part of: YDR084C
location: complement(<613405..>614004)
location: region:613405-614004:-1
so has part: feature:613405-614004:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:613405-614004:-1:exon

YDR084C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TVP23
locus tag: YDR084C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]
note: Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
codon start: 1
product: Tvp23p
translation: MDQARNFYNTILKSSHPLLLSFHLAGKAVPIVFYIIGSMFLNFTPQFITVVLLLSFDFYLTKNITGRKLVQLRWWYDSTDVNKDSNFTFESYKQYAPGPPINAIDSKLFWWSMYVTPVIWGVFAVLCLLRLKIFYLILVIVAMCLTAWNTYGFRCCDRWEPNSGQSDGQDTNNWFALPSVPGFENLSRLANIQSFFQRQ
SIO_010081: YDR084C
subclass of: SO_0000673
so part of: YDR084C
location: complement(613405..614004)
location: region:613405-614004:-1
so has part: feature:613405-614004:-1:exon

NP_010369.3
type: Protein
SIO_000068: ncbiprotein

S000002491
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:613405-614004:-1:exon

YDR085C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AFR1
locus tag: YDR085C
so part of: sequence
location: complement(<614288..>616150)
location: region:614288-616150:-1
so has part: feature:614288-616150:-1:exon
subclass of: SO_0000010

851658
type: Gene
SIO_000068: ncbigene

position:614288:-1
position: 614288
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:616150:-1
position: 616150
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:614288-616150:-1:exon

YDR085C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AFR1
locus tag: YDR085C
product: Afr1p
transcript id: NM_001180393.1
SIO_010081: YDR085C
subclass of: SO_0000673
so part of: YDR085C
location: complement(<614288..>616150)
location: region:614288-616150:-1
so has part: feature:614288-616150:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:614288-616150:-1:exon

YDR085C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AFR1
locus tag: YDR085C
experiment: EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:7823940]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:18552279|PMID:8413281]
experiment: EXISTENCE:mutant phenotype:GO:0032185 septin cytoskeleton organization [PMID:18552279]
experiment: EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:18552279]
note: Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; also detected in peroxisomes; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
codon start: 1
product: Afr1p
translation: MEGSYLSAQENQPIPERLIPRSNSTSNLFALSSTFSKLNVRNDADYNYSNPNKKRHIYSGEIDCRSVTAARKFPVRSCSMTAAQQRKRTALFTVRERNSYHEGFNNDQDYVSQYQKPQYTFGVYKELTPYQLQRSKMKRSFQFPNGEIYKPKLDGKCTHSLKKPELNSRDSSLFKFSEKKGRNLSKDFVGPHNGTSVIHIPPNDTGYGVNSLELNTSVPSTIKSSVSSTSPISAVNTLTSLPESQTDDDDGYENKTVTISYCFENTVNEKHGSHIEKLDLSTKEKTKPTTNSGLFDRKKKTILGTEKYRCIKSQSKLKLGSVLKKLWRTSGNSNTKHGKKDTKRRRIPIDDMVTHSDGNSEAENDIELMDANLDGIEFDDDETLMDTDSIFDDLLSKENDKYDLRRRQLEIRQKLHETSHNDDGKVSFRDTEKHNVNEGLIDKTIIEEFSKLGEYIIDTRNQPPPRSSKRPSLDDNESARYFYNISTDLRQSLSGPISLPMHVGNDMVNRLRNDWEYIRFEDRRNSLPDSSFDKVETPPKPIKKDVRFAKEVCLASTWSSNAYERANPEFIMNRHRLLWMMKVHPSMNSAMNEIKLELNSYKKNEMVVHENSKCFTHYLI
SIO_010081: YDR085C
subclass of: SO_0000673
so part of: YDR085C
location: complement(614288..616150)
location: region:614288-616150:-1
so has part: feature:614288-616150:-1:exon

NP_010370.1
type: Protein
SIO_000068: ncbiprotein

S000002492
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:614288-616150:-1:exon

YDR086C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SSS1
locus tag: YDR086C
so part of: sequence
location: complement(<616928..>617170)
location: region:616928-617170:-1
so has part: feature:616928-617170:-1:exon
subclass of: SO_0000010

851659
type: Gene
SIO_000068: ncbigene

position:616928:-1
position: 616928
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:617170:-1
position: 617170
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616928-617170:-1:exon

YDR086C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SSS1
locus tag: YDR086C
product: translocon subunit SSS1
transcript id: NM_001180394.1
SIO_010081: YDR086C
subclass of: SO_0000673
so part of: YDR086C
location: complement(<616928..>617170)
location: region:616928-617170:-1
so has part: feature:616928-617170:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:616928-617170:-1:exon

YDR086C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SSS1
locus tag: YDR086C
experiment: EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:27831485]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005784 Sec61 translocon complex [PMID:7758110|PMID:8612571]
experiment: EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]
experiment: EXISTENCE:direct assay:GO:0015450 protein-transporting ATPase activity [PMID:7758110]
experiment: EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]
experiment: EXISTENCE:direct assay:GO:0071261 Ssh1 translocon complex [PMID:8612571]
experiment: EXISTENCE:genetic interaction:GO:0005198 structural molecule activity [PMID:7961662]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:7961662]
experiment: EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:12860997]
note: Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
codon start: 1
product: translocon subunit SSS1
translation: MARASEKGEEKKQSNNQVEKLVEAPVEFVREGTQFLAKCKKPDLKEYTKIVKAVGIGFIAVGIIGYAIKLIHIPIRYVIV
SIO_010081: YDR086C
subclass of: SO_0000673
so part of: YDR086C
location: complement(616928..617170)
location: region:616928-617170:-1
so has part: feature:616928-617170:-1:exon

NP_010371.1
type: Protein
SIO_000068: ncbiprotein

S000002493
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:616928-617170:-1:exon

YDR087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP1
locus tag: YDR087C
so part of: sequence
location: complement(<617470..>618306)
location: region:617470-618306:-1
so has part: feature:617470-618306:-1:exon
subclass of: SO_0000010

851660
type: Gene
SIO_000068: ncbigene

position:617470:-1
position: 617470
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:618306:-1
position: 618306
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:617470-618306:-1:exon

YDR087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP1
locus tag: YDR087C
product: Rrp1p
transcript id: NM_001180395.3
SIO_010081: YDR087C
subclass of: SO_0000673
so part of: YDR087C
location: complement(<617470..>618306)
location: region:617470-618306:-1
so has part: feature:617470-618306:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:617470-618306:-1:exon

YDR087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP1
locus tag: YDR087C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:3549696]
note: Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles
codon start: 1
product: Rrp1p
translation: METSNFVKQLSSNNRKTRVNALEALKKYLTAKQFKENKQIEFNKLWKGLYYAMWFSDRPRPQQRLANELGELHGLYFDPKDNSTADELTTNDKAFIKFSRGFWKVMCFEWFNIDRYRLDKYLLLIRRVLFSQLKYLQSRNWDKKLVDEYIKKVLRWLPLSGSPKVYTGIPIHIVDILLDEWERLLKDGDEDDEDEENKEEEMRKIAESAKKTPLADVIAIFQDIVADYNNSKVLREKIKEDLFSDTRLVSWDILEGETQHNDSSNESEEEEEEEWKGF
SIO_010081: YDR087C
subclass of: SO_0000673
so part of: YDR087C
location: complement(617470..618306)
location: region:617470-618306:-1
so has part: feature:617470-618306:-1:exon

NP_010372.3
type: Protein
SIO_000068: ncbiprotein

S000002494
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:617470-618306:-1:exon

YDR088C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SLT17
gene: SLU7
locus tag: YDR088C
gene synonym: SLT17
so part of: sequence
location: complement(<618497..>619645)
location: region:618497-619645:-1
so has part: feature:618497-619645:-1:exon
subclass of: SO_0000010

851661
type: Gene
SIO_000068: ncbigene

position:618497:-1
position: 618497
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:619645:-1
position: 619645
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:618497-619645:-1:exon

YDR088C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SLT17
gene: SLU7
locus tag: YDR088C
gene synonym: SLT17
product: mRNA splicing protein SLU7
transcript id: NM_001180396.3
SIO_010081: YDR088C
subclass of: SO_0000673
so part of: YDR088C
location: complement(<618497..>619645)
location: region:618497-619645:-1
so has part: feature:618497-619645:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:618497-619645:-1:exon

YDR088C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SLT17
gene: SLU7
locus tag: YDR088C
gene synonym: SLT17
experiment: EXISTENCE:direct assay:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0000386 second spliceosomal transesterification activity [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0071021 U2-type post-spliceosomal complex [PMID:12212850]
note: RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
codon start: 1
product: mRNA splicing protein SLU7
translation: MNNNSRNNENRSTINRNKRQLQQAKEKNENIHIPRYIRNQPWYYKDTPKEQEGKKPGNDDTSTAEGGEKSDYLVHHRQKAKGGALDIDNNSEPKIGMGIKDEFKLIRPQKMSVRDSHSLSFCRNCGEAGHKEKDCMEKPRKMQKLVPDLNSQKNNGTVLVRATDDDWDSRKDRWYGYSGKEYNELISKWERDKRNKIKGKDKSQTDETLWDTDEEIELMKLELYKDSVGSLKKDDADNSQLYRTSTRLREDKAAYLNDINSTESNYDPKSRLYKTETLGAVDEKSKMFRRHLTGEGLKLNELNQFARSHAKEMGIRDEIEDKEKVQHVLVANPTKYEYLKKKREQEETKQPKIVSIGDLEARKVDGTKQSEEQRNHLKDLYG
SIO_010081: YDR088C
subclass of: SO_0000673
so part of: YDR088C
location: complement(618497..619645)
location: region:618497-619645:-1
so has part: feature:618497-619645:-1:exon

NP_010373.3
type: Protein
SIO_000068: ncbiprotein

S000002495
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:618497-619645:-1:exon

YNCD0013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0013C
so part of: sequence
location: complement(619969..620041)
location: region:619969-620041:-1
so has part: feature:619969-620041:-1:exon
subclass of: SO_0000663

851662
type: Gene
SIO_000068: ncbigene

position:619969:-1
position: 619969
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:620041:-1
position: 620041
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:619969-620041:-1:exon

YNCD0013C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0013C
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 6 nuclear tRNA genes containing the tDNA-anticodon ACG (converted to ICG in the mature tRNA), decodes CGU, CGC, and probably CGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCD0013C
subclass of: SO_0000673
so part of: YNCD0013C
location: complement(619969..620041)
location: region:619969-620041:-1
so has part: feature:619969-620041:-1:exon

S000006700
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:619969-620041:-1:exon

YDR089W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VTC5
locus tag: YDR089W
so part of: sequence
location: <622112..>624721
location: region:622112-624721:1
so has part: feature:622112-624721:1:exon
subclass of: SO_0000010

851663
type: Gene
SIO_000068: ncbigene

position:622112:1
position: 622112
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:624721:1
position: 624721
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:622112-624721:1:exon

YDR089W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VTC5
locus tag: YDR089W
product: Vtc5p
transcript id: NM_001180397.1
SIO_010081: YDR089W
subclass of: SO_0000673
so part of: YDR089W
location: <622112..>624721
location: region:622112-624721:1
so has part: feature:622112-624721:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:622112-624721:1:exon

YDR089W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VTC5
locus tag: YDR089W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:27587415|PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0006799 polyphosphate biosynthetic process [PMID:27587415]
experiment: EXISTENCE:mutant phenotype:GO:0030643 cellular phosphate ion homeostasis [PMID:27587415]
experiment: EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:27587415]
note: Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
codon start: 1
product: Vtc5p
translation: MKFEDRILNKSIPEWKFYNINYEKLKVAIKKVTAYDYDNPNDSGMEKLLNQCSVAFDQEFQNVNLFVSLKIKEISTRILSVESSIIDFSKGLNKTSRNRFNLRKLKIINAHVDDCNFELQLLSRFLIIQRIALRKLFKKLLNEFPQDSENPLTASEYVTSIRNSESLRNGHEGISFMKLDLDPYLLEVSLIVDVLHDLENKLEDATEPAVEQRSLNRSDESAHTSSSPEANNSSLPASPRSIPLLSNKKTSKMIDSSLEFDTALIDKAENLGRFLLSSEDIEGLKFMLLNIGFRIIDDSIISTSKEILDTTDNINSAGNKSIRSAKSFNDLQHTLSLSKQKNILPSAVQSNEKYVSISILDTVGNEGSPLLLTDDNINQHPNMIVSSTAEDTCIVMCHVGGLRNHVVTNDLLLRDVKNILSAMRSGNDTKNISALINSLDPSPISKIALEWIQSHRLKTIEPKLDFKRTRFISADNGDIYLIALDESITIGNVSTLPFPILEIKKLSRSSGLSQTAINEDNKFKQLMKSVVTNEFQCSLIPPDLTTWKICLELVHSNELQNDLFQLLLRDQYKLNSDDSLSPDEFFQLGKDRLEEEFDLTGPINNSQGSVDSGRRVRIHKKSKQSDNETKKKPIRYWNEFDEQEEDNLDNAFYIDTNGSRSTTDNEESLLLRNSPPDYGFILFSRNFINRTYDFCEKLRNLIRHDKKTSPDLFQNSKHPHCSSTNYGSVASFGSQSTSASYDDVQRYLQYQQQDIEDSQSIYEYRHDEVVTFLYLSALLTSCIMASVCLGIVLSLFRGQSNNEIDLEIQNILIAIIIISLLVSLILICACLLLLFSRFTLAPIWHYVGCFTMFFSVTGTVCYGMIEIFF
SIO_010081: YDR089W
subclass of: SO_0000673
so part of: YDR089W
location: 622112..624721
location: region:622112-624721:1
so has part: feature:622112-624721:1:exon

NP_010374.1
type: Protein
SIO_000068: ncbiprotein

S000002496
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:622112-624721:1:exon

YDR090C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ILT1
locus tag: YDR090C
so part of: sequence
location: complement(<625066..>625998)
location: region:625066-625998:-1
so has part: feature:625066-625998:-1:exon
subclass of: SO_0000010

851664
type: Gene
SIO_000068: ncbigene

position:625066:-1
position: 625066
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:625998:-1
position: 625998
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:625066-625998:-1:exon

YDR090C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ILT1
locus tag: YDR090C
product: Ilt1p
transcript id: NM_001180398.1
SIO_010081: YDR090C
subclass of: SO_0000673
so part of: YDR090C
location: complement(<625066..>625998)
location: region:625066-625998:-1
so has part: feature:625066-625998:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:625066-625998:-1:exon

YDR090C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ILT1
locus tag: YDR090C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30045857]
note: hypothetical protein; deletion confers sensitivity to cationic compounds; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane
codon start: 1
product: Ilt1p
translation: MISEKAATALATIATVCWCVQLIPQIIYNWKKKDCTGLPPLMMFLWVVSGIPFAIYFCVSKGNVILQVQPHLFMFFCSISFVQSCYYPPISMARSKIVMIVAAIIAADVGMEVGFILWLRPLYEKGVKWPDLIFGISASVLLAVGLLPPYFELAKRKGRVIGINFAFLFIDSLGAWLSIISVILGNMDIMGIILYSIVAGMELGIFASHFIWWCRFRFLAKGNTFDEESGQAQKEEPDEKIEQDISKSDRNVTNYNLDNCSIPDDASSFADDFNIYDSTDGGTLSRAQTLHAVHGVVVRTDPDRYSRLSV
SIO_010081: YDR090C
subclass of: SO_0000673
so part of: YDR090C
location: complement(625066..625998)
location: region:625066-625998:-1
so has part: feature:625066-625998:-1:exon

NP_010375.1
type: Protein
SIO_000068: ncbiprotein

S000002497
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:625066-625998:-1:exon

YDR091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RLI1
locus tag: YDR091C
so part of: sequence
location: complement(<626708..>628534)
location: region:626708-628534:-1
so has part: feature:626708-628534:-1:exon
subclass of: SO_0000010

851665
type: Gene
SIO_000068: ncbigene

position:626708:-1
position: 626708
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:628534:-1
position: 628534
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:626708-628534:-1:exon

YDR091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RLI1
locus tag: YDR091C
product: Fe-S cluster-binding ribosome biosynthesis protein
transcript id: NM_001180399.3
SIO_010081: YDR091C
subclass of: SO_0000673
so part of: YDR091C
location: complement(<626708..>628534)
location: region:626708-628534:-1
so has part: feature:626708-628534:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:626708-628534:-1:exon

YDR091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RLI1
locus tag: YDR091C
experiment: EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:15660134]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15277527]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15277527|PMID:15660134|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:15277527]
experiment: EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:24424461]
experiment: EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:20062004]
experiment: EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:15660134|PMID:22855532]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:15277527|PMID:15660134]
experiment: EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:22770215]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:15277527]
experiment: EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]
experiment: EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:20062004]
note: Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress
codon start: 1
product: Fe-S cluster-binding ribosome biosynthesis protein
translation: MSDKNSRIAIVSADKCKPKKCRQECKRSCPVVKTGKLCIEVTPTSKIAFISEILCIGCGICVKKCPFDAIQIINLPTNLEAHVTHRYSANSFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILAGKQKPNLGRFDDPPEWQEIIKYFRGSELQNYFTKMLEDDIKAIIKPQYVDNIPRAIKGPVQKVGELLKLRMEKSPEDVKRYIKILQLENVLKRDIEKLSGGELQRFAIGMSCVQEADVYMFDEPSSYLDVKQRLNAAQIIRSLLAPTKYVICVEHDLSVLDYLSDFVCIIYGVPSVYGVVTLPASVREGINIFLDGHIPAENLRFRTEALQFRIADATEDLQNDSASRAFSYPSLKKTQGDFVLNVEEGEFSDSEILVMMGENGTGKTTLIKLLAGALKPDEGQDIPKLNVSMKPQKIAPKFPGTVRQLFFKKIRGQFLNPQFQTDVVKPLRIDDIIDQEVQHLSGGELQRVAIVLALGIPADIYLIDEPSAYLDSEQRIICSKVIRRFILHNKKTAFIVEHDFIMATYLADKVIVFEGIPSKNAHARAPESLLTGCNRFLKNLNVTFRRDPNSFRPRINKLDSQMDKEQKSSGNYFFLDNTGI
SIO_010081: YDR091C
subclass of: SO_0000673
so part of: YDR091C
location: complement(626708..628534)
location: region:626708-628534:-1
so has part: feature:626708-628534:-1:exon

NP_010376.3
type: Protein
SIO_000068: ncbiprotein

S000002498
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:626708-628534:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS420; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 628938..629582
location: region:628938-629582:1
so has part: feature:628938-629582:1:region

S000130174
type: SGD
SIO_000068: sgd

position:628938:1
position: 628938
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:629582:1
position: 629582
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628938-629582:1:region

YDR092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBC13
locus tag: YDR092W
so part of: sequence
location: <629876..>630605
location: region:629876-630605:1
so has part: feature:629876-630605:1:exon
subclass of: SO_0000010

851666
type: Gene
SIO_000068: ncbigene

position:629876:1
position: 629876
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:630605:1
position: 630605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:629876-630605:1:exon

YDR092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBC13
locus tag: YDR092W
product: E2 ubiquitin-conjugating protein UBC13
transcript id: NM_001180400.3
SIO_010081: YDR092W
subclass of: SO_0000673
so part of: YDR092W
location: join(<629876..629905,630174..>630605)
location: region:629876-630605:1
so has part: feature:629876-629905:1:exon
so has part: feature:630174-630605:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:629876-629905:1:exon

position:629905:1
position: 629905
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:630174-630605:1:exon

position:630174:1
position: 630174
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YDR092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBC13
locus tag: YDR092W
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:10089880]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:32265276]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10089880]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19706603]
experiment: EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:10089880]
experiment: EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:10089880]
experiment: EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:32265276]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]
experiment: EXISTENCE:physical interaction:GO:0031371 ubiquitin conjugating enzyme complex [PMID:10089880]
note: E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
codon start: 1
product: E2 ubiquitin-conjugating protein UBC13
translation: MASLPKRIIKETEKLVSDPVPGITAEPHDDNLRYFQVTIEGPEQSPYEDGIFELELYLPDDYPMEAPKVRFLTKIYHPNIDRLGRICLDVLKTNWSPALQIRTVLLSIQALLASPNPNDPLANDVAEDWIKNEQGAKAKAREWTKLYAKKKPE
SIO_010081: YDR092W
subclass of: SO_0000673
so part of: YDR092W
location: join(629876..629905,630174..630605)
location: region:629876-630605:1
so has part: feature:629876-629905:1:exon
so has part: feature:630174-630605:1:exon

NP_010377.3
type: Protein
SIO_000068: ncbiprotein

S000002499
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:629876-629905:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:630174-630605:1:exon

YDR093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DNF2
locus tag: YDR093W
so part of: sequence
location: <631282..>636120
location: region:631282-636120:1
so has part: feature:631282-636120:1:exon
subclass of: SO_0000010

851667
type: Gene
SIO_000068: ncbigene

position:631282:1
position: 631282
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:636120:1
position: 636120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:631282-636120:1:exon

YDR093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DNF2
locus tag: YDR093W
product: aminophospholipid-translocating P4-type ATPase DNF2
transcript id: NM_001180401.1
SIO_010081: YDR093W
subclass of: SO_0000673
so part of: YDR093W
location: <631282..>636120
location: region:631282-636120:1
so has part: feature:631282-636120:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:631282-636120:1:exon

YDR093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DNF2
locus tag: YDR093W
EC number: 7.6.2.1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12221123|PMID:12631737|PMID:33060204]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:25378585]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:25378585]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12631737]
experiment: EXISTENCE:genetic interaction:GO:0007163 establishment or maintenance of cell polarity [PMID:15461661]
experiment: EXISTENCE:genetic interaction:GO:0015247 aminophospholipid flippase activity [PMID:12631737|PMID:17015438]
experiment: EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:12631737|PMID:17015438]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12631737]
experiment: EXISTENCE:mutant phenotype:GO:0015247 aminophospholipid flippase activity [PMID:12631737|PMID:17015438]
experiment: EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:12631737|PMID:17015438]
experiment: EXISTENCE:mutant phenotype:GO:0099040 ceramide translocation [PMID:33060204]
experiment: EXISTENCE:mutant phenotype:GO:0140346 phosphatidylserine flippase activity [PMID:12631737]
experiment: EXISTENCE:mutant phenotype:GO:0140351 glycosylceramide flippase activity [PMID:33060204]
note: Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication
codon start: 1
product: aminophospholipid-translocating P4-type ATPase DNF2
translation: MSSPSKPTSPFVDDIEHESGSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDYSNDNDINDDDELNGKKTEIHEHENEVDDDLHSFQATPMPNTGGFEDVELDNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKKNFHNAIDEFSTKEDSLENSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLKCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRPRINEIRPLTDFKEPISLDTHFDGVSHSQETIVTEEIPMSILNGEQGSRKGYRVSTTLERRDQLSPVTTTNNLPRRSMASARGNKLRTSLDRTREEMLANHQLDTRYSVERARASLDLPGINHAETLLSQRSRDR
SIO_010081: YDR093W
subclass of: SO_0000673
so part of: YDR093W
location: 631282..636120
location: region:631282-636120:1
so has part: feature:631282-636120:1:exon

NP_010378.1
type: Protein
SIO_000068: ncbiprotein

S000002500
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:631282-636120:1:exon

YDR096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GIS1
locus tag: YDR096W
so part of: sequence
location: <637139..>639823
location: region:637139-639823:1
so has part: feature:637139-639823:1:exon
subclass of: SO_0000010

851670
type: Gene
SIO_000068: ncbigene

position:637139:1
position: 637139
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:639823:1
position: 639823
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:637139-639823:1:exon

YDR096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GIS1
locus tag: YDR096W
product: histone demethylase GIS1
transcript id: NM_001180404.1
SIO_010081: YDR096W
subclass of: SO_0000673
so part of: YDR096W
location: <637139..>639823
location: region:637139-639823:1
so has part: feature:637139-639823:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:637139-639823:1:exon

YDR096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GIS1
locus tag: YDR096W
experiment: EXISTENCE:curator inference:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10835355|PMID:12799368]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12799368]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:12799368]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15661010|PMID:22932476|PMID:14562095|PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10835355]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10523651|PMID:24140345]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:12799368]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10835355]
experiment: EXISTENCE:mutant phenotype:GO:0051864 histone H3K36 demethylase activity [PMID:17369256]
experiment: EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:12799368]
note: Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
codon start: 1
product: histone demethylase GIS1
translation: MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENGIVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAESLDSRISQGDFNDKTLKENCRVDSQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSINSSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNNVSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNINPLDAGPSFSPLHKKPKILNGNDNSNLDSNNFDYSFTGNKQESNPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYICRECNRQFSSGHHLTRHKKSVHSGEKPHSCPRCGKRFKRRDHVLQHLNKKIPCTQEMENTKLAES
SIO_010081: YDR096W
subclass of: SO_0000673
so part of: YDR096W
location: 637139..639823
location: region:637139-639823:1
so has part: feature:637139-639823:1:exon

NP_010381.1
type: Protein
SIO_000068: ncbiprotein

S000002503
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:637139-639823:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS421; Autonomously Replicating Sequence
so part of: sequence
location: 640006..640072
location: region:640006-640072:1
so has part: feature:640006-640072:1:region

S000118437
type: SGD
SIO_000068: sgd

position:640006:1
position: 640006
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:640072:1
position: 640072
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:640006-640072:1:region

YDR097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PMS3
alternative label: PMS6
gene: MSH6
locus tag: YDR097C
gene synonym: PMS3; PMS6
so part of: sequence
location: complement(<640109..>643837)
location: region:640109-643837:-1
so has part: feature:640109-643837:-1:exon
subclass of: SO_0000010

851671
type: Gene
SIO_000068: ncbigene

position:640109:-1
position: 640109
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:643837:-1
position: 643837
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:640109-643837:-1:exon

YDR097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PMS3
alternative label: PMS6
gene: MSH6
locus tag: YDR097C
gene synonym: PMS3; PMS6
product: mismatch repair ATPase MSH6
transcript id: NM_001180405.3
SIO_010081: YDR097C
subclass of: SO_0000673
so part of: YDR097C
location: complement(<640109..>643837)
location: region:640109-643837:-1
so has part: feature:640109-643837:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:640109-643837:-1:exon

YDR097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PMS3
alternative label: PMS6
gene: MSH6
locus tag: YDR097C
gene synonym: PMS3; PMS6
experiment: EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:10066781]
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9545323]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006298 mismatch repair [PMID:11237611]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9819445]
experiment: EXISTENCE:direct assay:GO:0032137 guanine/thymine mispair binding [PMID:8816473]
experiment: EXISTENCE:direct assay:GO:0032138 single base insertion or deletion binding [PMID:8816473]
experiment: EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]
experiment: EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551|PMID:9520271]
experiment: EXISTENCE:mutant phenotype:GO:0032138 single base insertion or deletion binding [PMID:10347163]
experiment: EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:27045900]
experiment: EXISTENCE:physical interaction:GO:0032301 MutSalpha complex [PMID:8816473]
note: Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p; contains PIP motif that binds PCNA (Pol30p) and Rev1p
codon start: 1
product: mismatch repair ATPase MSH6
translation: MAPATPKTSKTAHFENGSTSSQKKMKQSSLLSFFSKQVPSGTPSKKVQKPTPATLENTATDKITKNPQGGKTGKLFVDVDEDNDLTIAEETVSTVRSDIMHSQEPQSDTMLNSNTTEPKSTTTDEDLSSSQSRRNHKRRVNYAESDDDDSDTTFTAKRKKGKVVDSESDEDEYLPDKNDGDEDDDIADDKEDIKGELAEDSGDDDDLISLAETTSKKKFSYNTSHSSSPFTRNISRDNSKKKSRPNQAPSRSYNPSHSQPSATSKSSKFNKQNEERYQWLVDERDAQRRPKSDPEYDPRTLYIPSSAWNKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYEKDALLANALFDLKIAGGGRANMQLAGIPEMSFEYWAAQFIQMGYKVAKVDQRESMLAKEMREGSKGIVKRELQCILTSGTLTDGDMLHSDLATFCLAIREEPGNFYNETQLDSSTIVQKLNTKIFGAAFIDTATGELQMLEFEDDSECTKLDTLMSQVRPMEVVMERNNLSTLANKIVKFNSAPNAIFNEVKAGEEFYDCDKTYAEIISSEYFSTEEDWPEVLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKNLISMKNIKEYDFVKSQHSMVLDGITLQNLEIFSNSFDGSDKGTLFKLFNRAITPMGKRMMKKWLMHPLLRKNDIESRLDSVDSLLQDITLREQLEITFSKLPDLERMLARIHSRTIKVKDFEKVITAFETIIELQDSLKNNDLKGDVSKYISSFPEGLVEAVKSWTNAFERQKAINENIIVPQRGFDIEFDKSMDRIQELEDELMEILMTYRKQFKCSNIQYKDSGKEIYTIEIPISATKNVPSNWVQMAANKTYKRYYSDEVRALARSMAEAKEIHKTLEEDLKNRLCQKFDAHYNTIWMPTIQAISNIDCLLAITRTSEYLGAPSCRPTIVDEVDSKTNTQLNGFLKFKSLRHPCFNLGATTAKDFIPNDIELGKEQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAVLTPIDRIMTRLGANDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIAESVLHHVATHIQSLGFFATHYGTLASSFKHHPQVRPLKMSILVDEATRNVTFLYKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNLEHTSRLVKERDLAANNLNGEVVSVPGGLQSDFVRIAYGDGLKNTKLGSGEGVLNYDWNIKRNVLKSLFSIIDDLQS
SIO_010081: YDR097C
subclass of: SO_0000673
so part of: YDR097C
location: complement(640109..643837)
location: region:640109-643837:-1
so has part: feature:640109-643837:-1:exon

NP_010382.3
type: Protein
SIO_000068: ncbiprotein

S000002504
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:640109-643837:-1:exon

YDR098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GRX3
locus tag: YDR098C
so part of: sequence
location: complement(<644178..>644930)
location: region:644178-644930:-1
so has part: feature:644178-644930:-1:exon
subclass of: SO_0000010

851672
type: Gene
SIO_000068: ncbigene

position:644178:-1
position: 644178
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:644930:-1
position: 644930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:644178-644930:-1:exon

YDR098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GRX3
locus tag: YDR098C
product: monothiol glutaredoxin GRX3
transcript id: NM_001180406.4
SIO_010081: YDR098C
subclass of: SO_0000673
so part of: YDR098C
location: complement(<644178..>644930)
location: region:644178-644930:-1
so has part: feature:644178-644930:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:644178-644930:-1:exon

YDR098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GRX3
locus tag: YDR098C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15456753]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18281282]
experiment: EXISTENCE:direct assay:GO:0051536 iron-sulfur cluster binding [PMID:31493153]
experiment: EXISTENCE:genetic interaction:GO:0006879 cellular iron ion homeostasis [PMID:17074835]
experiment: EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:10567543|PMID:27085841]
experiment: EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:20889785]
experiment: EXISTENCE:mutant phenotype:GO:0031065 positive regulation of histone deacetylation [PMID:27085841]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17074835|PMID:10567543]
experiment: EXISTENCE:mutant phenotype:GO:2000678 negative regulation of transcription regulatory region DNA binding [PMID:23045394]
experiment: EXISTENCE:physical interaction:GO:0006879 cellular iron ion homeostasis [PMID:17074835]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:23045394]
note: Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx4p and Grx5p; redundantly protects cells from oxidative damage along with GRX4 and GRX5; with Grx4p, promotes the dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx4p in the deglutathionylation of Sir2p, restoring deacetylase activity after disulfide stress
codon start: 1
product: monothiol glutaredoxin GRX3
translation: MPVIEINDQEQFTYLTTTAAGDKLIVLYFHTSWAEPCKALKQVFEAISNEPSNSNVSFLSIDADENSEISELFEISAVPYFIIIHKGTILKELSGADPKEYVSLLEDCKNSVNSGSSQTHTMENANVNEGSHNDEDDDDEEEEEETEEQINARLTKLVNAAPVMLFMKGSPSEPKCGFSRQLVGILREHQVRFGFFDILRDESVRQNLKKFSEWPTFPQLYINGEFQGGLDIIKESLEEDPDFLQHALQS
SIO_010081: YDR098C
subclass of: SO_0000673
so part of: YDR098C
location: complement(644178..644930)
location: region:644178-644930:-1
so has part: feature:644178-644930:-1:exon

NP_010383.4
type: Protein
SIO_000068: ncbiprotein

S000002505
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:644178-644930:-1:exon

YNCD0014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCD0014C
so part of: sequence
location: complement(645153..645224)
location: region:645153-645224:-1
so has part: feature:645153-645224:-1:exon
subclass of: SO_0000663

851673
type: Gene
SIO_000068: ncbigene

position:645153:-1
position: 645153
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:645224:-1
position: 645224
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:645153-645224:-1:exon

YNCD0014C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCD0014C
product: tRNA-Gln
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
note: Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCD0014C
subclass of: SO_0000673
so part of: YNCD0014C
location: complement(645153..645224)
location: region:645153-645224:-1
so has part: feature:645153-645224:-1:exon

S000006694
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:645153-645224:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YDRCTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YDRCTy1-1
so part of: sequence
location: complement(645502..651419)
location: region:645502-651419:-1
so has part: feature:645502-651419:-1:region

S000006859
type: SGD
SIO_000068: sgd

position:645502:-1
position: 645502
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:651419:-1
position: 651419
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:645502-651419:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(645502..645835)
location: region:645502-645835:-1
so has part: feature:645502-645835:-1:region

S000006850
type: SGD
SIO_000068: sgd

position:645835:-1
position: 645835
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:645502-645835:-1:region

YDR098C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR098C-B
so part of: sequence
location: complement(<645858..>651126)
location: region:645858-651126:-1
so has part: feature:645858-651126:-1:exon
subclass of: SO_0000010

851674
type: Gene
SIO_000068: ncbigene

position:645858:-1
position: 645858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:651126:-1
position: 651126
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:645858-651126:-1:exon

YDR098C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR098C-B
product: gag-pol fusion protein
transcript id: NM_001184417.2
SIO_010081: YDR098C-B
subclass of: SO_0000673
so part of: YDR098C-B
location: complement(<645858..>651126)
location: region:645858-651126:-1
so has part: feature:645858-651126:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:645858-651126:-1:exon

YDR098C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR098C-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPGINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPNSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGEGDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGSLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YDR098C-B
subclass of: SO_0000673
so part of: YDR098C-B
location: complement(join(645858..649820,649822..651126))
location: region:645858-651126:-1
so has part: feature:649822-651126:-1:exon
so has part: feature:645858-649820:-1:exon

NP_058140.1
type: Protein
SIO_000068: ncbiprotein

S000007391
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:649822-651126:-1:exon

position:649822:-1
position: 649822
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:645858-649820:-1:exon

position:649820:-1
position: 649820
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YDR098C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR098C-A
so part of: sequence
location: complement(<649804..>651126)
location: region:649804-651126:-1
so has part: feature:649804-651126:-1:exon
subclass of: SO_0000010

851675
type: Gene
SIO_000068: ncbigene

position:649804:-1
position: 649804
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:649804-651126:-1:exon

YDR098C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR098C-A
product: gag protein
transcript id: NM_001184416.1
SIO_010081: YDR098C-A
subclass of: SO_0000673
so part of: YDR098C-A
location: complement(<649804..>651126)
location: region:649804-651126:-1
so has part: feature:649804-651126:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:649804-651126:-1:exon

YDR098C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR098C-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YDR098C-A
subclass of: SO_0000673
so part of: YDR098C-A
location: complement(649804..651126)
location: region:649804-651126:-1
so has part: feature:649804-651126:-1:exon

NP_058141.1
type: Protein
SIO_000068: ncbiprotein

S000007390
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:649804-651126:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(651086..651419)
location: region:651086-651419:-1
so has part: feature:651086-651419:-1:region

S000006851
type: SGD
SIO_000068: sgd

position:651086:-1
position: 651086
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:651086-651419:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(651420..651503)
location: region:651420-651503:-1
so has part: feature:651420-651503:-1:region

S000006855
type: SGD
SIO_000068: sgd

position:651420:-1
position: 651420
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:651503:-1
position: 651503
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:651420-651503:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(651682..651980)
location: region:651682-651980:-1
so has part: feature:651682-651980:-1:region

S000006852
type: SGD
SIO_000068: sgd

position:651682:-1
position: 651682
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:651980:-1
position: 651980
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:651682-651980:-1:region

YDR099W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCD3
gene: BMH2
locus tag: YDR099W
gene synonym: SCD3
so part of: sequence
location: <653607..>654428
location: region:653607-654428:1
so has part: feature:653607-654428:1:exon
subclass of: SO_0000010

851676
type: Gene
SIO_000068: ncbigene

position:653607:1
position: 653607
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:654428:1
position: 654428
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:653607-654428:1:exon

YDR099W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCD3
gene: BMH2
locus tag: YDR099W
gene synonym: SCD3
product: 14-3-3 family protein BMH2
transcript id: NM_001180407.3
SIO_010081: YDR099W
subclass of: SO_0000673
so part of: YDR099W
location: <653607..>654428
location: region:653607-654428:1
so has part: feature:653607-654428:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:653607-654428:1:exon

YDR099W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCD3
gene: BMH2
locus tag: YDR099W
gene synonym: SCD3
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12167636]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12167636|PMID:25409301|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25409301|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:genetic interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:19934224]
experiment: EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:19934224]
experiment: EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0030437 ascospore formation [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:17559233]
experiment: EXISTENCE:genetic interaction:GO:0070873 regulation of glycogen metabolic process [PMID:9215628]
experiment: EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:14704161]
experiment: EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:22785534]
experiment: EXISTENCE:mutant phenotype:GO:0050815 phosphoserine residue binding [PMID:9822578]
experiment: EXISTENCE:physical interaction:GO:1904667 negative regulation of ubiquitin protein ligase activity [PMID:17030612]
note: 14-3-3 protein, minor isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates multiple processes including exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; abundance relative to Bmh1p increases during sporulation; similar to several human 14-3-3 proteins
codon start: 1
product: 14-3-3 family protein BMH2
translation: MSQTREDSVYLAKLAEQAERYEEMVENMKAVASSGQELSVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKEKSEHQVELIRSYRSKIETELTKISDDILSVLDSHLIPSATTGESKVFYYKMKGDYHRYLAEFSSGDAREKATNSSLEAYKTASEIATTELPPTHPIRLGLALNFSVFYYEIQNSPDKACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDISESGQEDQQQQQQQQQQQQQQQQQAPAEQTQGEPTK
SIO_010081: YDR099W
subclass of: SO_0000673
so part of: YDR099W
location: 653607..654428
location: region:653607-654428:1
so has part: feature:653607-654428:1:exon

NP_010384.3
type: Protein
SIO_000068: ncbiprotein

S000002506
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:653607-654428:1:exon

YDR100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TVP15
locus tag: YDR100W
so part of: sequence
location: <655013..>655444
location: region:655013-655444:1
so has part: feature:655013-655444:1:exon
subclass of: SO_0000010

851677
type: Gene
SIO_000068: ncbigene

position:655013:1
position: 655013
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:655444:1
position: 655444
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:655013-655444:1:exon

YDR100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TVP15
locus tag: YDR100W
product: Tvp15p
transcript id: NM_001180408.3
SIO_010081: YDR100W
subclass of: SO_0000673
so part of: YDR100W
location: <655013..>655444
location: region:655013-655444:1
so has part: feature:655013-655444:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:655013-655444:1:exon

YDR100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TVP15
locus tag: YDR100W
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]
note: Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p
codon start: 1
product: Tvp15p
translation: MSVIPPKFFKIANISIGCIDIIAALSQLTYIFTNLNVFLLAVYGLALSVPIVYLEFKVPSNLYRYASFYFSFLGRGLSYILLSLIISFGGIYNILAGMFTFILGVAFIVFHFSQFVEEPANFRAPGSSLSIGDDDIDDDDDMI
SIO_010081: YDR100W
subclass of: SO_0000673
so part of: YDR100W
location: 655013..655444
location: region:655013-655444:1
so has part: feature:655013-655444:1:exon

NP_010385.3
type: Protein
SIO_000068: ncbiprotein

S000002507
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:655013-655444:1:exon

YDR101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARX1
locus tag: YDR101C
so part of: sequence
location: complement(<655686..>657467)
location: region:655686-657467:-1
so has part: feature:655686-657467:-1:exon
subclass of: SO_0000010

851678
type: Gene
SIO_000068: ncbigene

position:655686:-1
position: 655686
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:657467:-1
position: 657467
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:655686-657467:-1:exon

YDR101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARX1
locus tag: YDR101C
product: putative hydrolase
transcript id: NM_001180409.1
SIO_010081: YDR101C
subclass of: SO_0000673
so part of: YDR101C
location: complement(<655686..>657467)
location: region:655686-657467:-1
so has part: feature:655686-657467:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:655686-657467:-1:exon

YDR101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARX1
locus tag: YDR101C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16648468]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:16648468|PMID:12374754]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16648468]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16648468|PMID:12374754]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:16648468]
experiment: EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:17803941|PMID:18077551]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16648468|PMID:18077551]
note: Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex
codon start: 1
product: putative hydrolase
translation: MALAISHEDTQILLKDKNILQESVLNKYRTAGQIAQTALKYVTSLINDSYHSKTTQRQLTVPELCLLTDSFILTRLEQYYKNKVNERGIAIPTTIDIDQISGGWCPEIDDTQNLLNWNKGKDSTFASSVTGTLRPGDLVKITLGVHIDGYTSEVSHTMVIYPVDETKPILQPTGPLLGGKADAVAAAHIAMETVVALLACALTPEKLPASLGGTSSGITGQLIRTIVDTIARSYNCGVVPGSRVRRIRRFLAGQNEGIVAEREYKGVVWTESHQEADLLSNTDAKDLTVVDRGQSTPFTNVSAIPSDDFVVQSGEVYLIDLKMASLEHCTKKGLVTLETVDSYTGKSHKAGELIARPGAYVRDFAQTHILKLKTSRQLLTKIDKQGVYPFKLSHLSSNFPFVHENEEELQSLKKDLKSFRLGMSEISNNYLCVESPIQIARWVPWDHILKATNPNGNLSYDATSTLTLPGHELPLPKLGVSAIKLKSLMNSTKESISLPVARECNTIVLCDSSVSTTDRPELLRLTGGSKTCQPSWIHSQHELNPQDSIVQGIFQLATLAKDKRFGLLLKETQPMKQKSVETSNGGVEETMKM
SIO_010081: YDR101C
subclass of: SO_0000673
so part of: YDR101C
location: complement(655686..657467)
location: region:655686-657467:-1
so has part: feature:655686-657467:-1:exon

NP_010386.1
type: Protein
SIO_000068: ncbiprotein

S000002508
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:655686-657467:-1:exon

YDR102C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YDR102C
so part of: sequence
location: complement(<657648..>657980)
location: region:657648-657980:-1
so has part: feature:657648-657980:-1:exon
subclass of: SO_0000010

851679
type: Gene
SIO_000068: ncbigene

position:657648:-1
position: 657648
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:657980:-1
position: 657980
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:657648-657980:-1:exon

YDR102C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YDR102C
product: uncharacterized protein
transcript id: NM_001348810.1
SIO_010081: YDR102C
subclass of: SO_0000673
so part of: YDR102C
location: complement(<657648..>657980)
location: region:657648-657980:-1
so has part: feature:657648-657980:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:657648-657980:-1:exon

YDR102C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YDR102C
note: hypothetical protein; conserved among S. cerevisiae strains; YDR102C is not an essential gene; homozygous diploid deletion strain exhibits high budding index
codon start: 1
product: uncharacterized protein
translation: MTLLLQKCIRVELRKDPIFNASSSLEIFLSVLESVIYPFKGNLILLDFHLVDVQTTCYQRNSSMRNQLMSVFCQSLREFTLTALSCNSYCIIIVATRWQKIDNALKMTGR
SIO_010081: YDR102C
subclass of: SO_0000673
so part of: YDR102C
location: complement(657648..657980)
location: region:657648-657980:-1
so has part: feature:657648-657980:-1:exon

NP_001335756.1
type: Protein
SIO_000068: ncbiprotein

S000002509
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:657648-657980:-1:exon

YDR103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HMD3
alternative label: NUL3
gene: STE5
locus tag: YDR103W
gene synonym: HMD3; NUL3
so part of: sequence
location: <658350..>661103
location: region:658350-661103:1
so has part: feature:658350-661103:1:exon
subclass of: SO_0000010

851680
type: Gene
SIO_000068: ncbigene

position:658350:1
position: 658350
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:661103:1
position: 661103
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:658350-661103:1:exon

YDR103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HMD3
alternative label: NUL3
gene: STE5
locus tag: YDR103W
gene synonym: HMD3; NUL3
product: Ste5p
transcript id: NM_001180411.1
SIO_010081: YDR103W
subclass of: SO_0000673
so part of: YDR103W
location: <658350..>661103
location: region:658350-661103:1
so has part: feature:658350-661103:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:658350-661103:1:exon

YDR103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HMD3
alternative label: NUL3
gene: STE5
locus tag: YDR103W
gene synonym: HMD3; NUL3
experiment: EXISTENCE:direct assay:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8062390]
experiment: EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:19303851]
experiment: EXISTENCE:direct assay:GO:0005078 MAP-kinase scaffold activity [PMID:8062390]
experiment: EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:16847350]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9732267]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11781566]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11781566|PMID:17952059]
experiment: EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:9732267]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:15192700]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:16847350]
experiment: EXISTENCE:mutant phenotype:GO:0010525 regulation of transposition, RNA-mediated [PMID:9566871]
experiment: EXISTENCE:mutant phenotype:GO:0043409 negative regulation of MAPK cascade [PMID:16424299]
experiment: EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:7851759]
experiment: EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:7667635]
note: Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation
codon start: 1
product: Ste5p
translation: MMETPTDNIVSPFHNFGSSTQYSGTLSRTPNQIIELEKPSTLSPLSRGKKWTEKLARFQRSSAKKKRFSPSPISSSTFSFSPKSRVTSSNSSGNEDGNLMNTPSTVSTDYLPQHPHRTSSLPRPNSNLFHASNSNLSRANEPPRAENLSDNIPPKVAPFGYPIQRTSIKKSFLNASCTLCDEPISNRRKGEKIIELACGHLSHQECLIISFGTTSKADVRALFPFCTKCKKDTNKAVQCIPENDELKDILISDFLIHKIPDSELSITPQSRFPPYSPLLPPFGLSYTPVERQTIYSQAPSLNPNLILAAPPKERNQIPQKKSNYTFLHSPLGHRRIPSGANSILADTSVALSANDSISAVSNSVRAKDDETKTTLPLLRSYFIQILLNNFQEELQDWRIDGDYGLLRLVDKLMISKDGQRYIQCWCFLFEDAFVIAEVDNDVDVLEIRLKNLEVFTPIANLRMTTLEASVLKCTLNKQHCADLSDLYIVQNINSDESTTVQKWISGILNQDFVFNEDNITSTLPILPIIKNFSKDVGNGRHETSTFLGLINPNKVVEVGNVHDNDTVIIRRGFTLNSGECSRQSTVDSIQSVLTTISSILSLKREKPDNLAIILQIDFTKLKEEDSLIVVYNSLKALTIKFARLQFCFVDRNNYVLDYGSVLHKIDSLDSISNLKSKSSSTQFSPIWLKNTLYPENIHEHLGIVAVSNSNMEAKKSILFQDYRCFTSFGRRRPNELKIKVGYLNVDYSDKIDELVEASSWTFVLETLCYSFGLSFDEHDDDDEEDNDDSTDNELDNSSGSLSDAESTTTIHIDSPFDNENATANMVNDRNLLTEGEHSNIENLETVASSVQPALIPNIRFSLHSEEEGTNENENENDMPVLLLSDMDKGIDGITRRSSFSSLIESGNNNCPLHMDYI
SIO_010081: YDR103W
subclass of: SO_0000673
so part of: YDR103W
location: 658350..661103
location: region:658350-661103:1
so has part: feature:658350-661103:1:exon

NP_010388.1
type: Protein
SIO_000068: ncbiprotein

S000002510
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:658350-661103:1:exon

YDR104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO71
locus tag: YDR104C
so part of: sequence
location: complement(<661173..>664910)
location: region:661173-664910:-1
so has part: feature:661173-664910:-1:exon
subclass of: SO_0000010

851681
type: Gene
SIO_000068: ncbigene

position:661173:-1
position: 661173
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:664910:-1
position: 664910
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:661173-664910:-1:exon

YDR104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO71
locus tag: YDR104C
product: Spo71p
transcript id: NM_001180412.3
SIO_010081: YDR104C
subclass of: SO_0000673
so part of: YDR104C
location: complement(<661173..>664910)
location: region:661173-664910:-1
so has part: feature:661173-664910:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:661173-664910:-1:exon

YDR104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO71
locus tag: YDR104C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24036347]
experiment: EXISTENCE:direct assay:GO:1902657 protein localization to prospore membrane [PMID:24036347]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:22611022|PMID:26605945|PMID:27303688]
note: Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation and closure; genetically antagonistic to SPO1; recruits Vps13p to the PSM during sporulation; interacts and functions cooperatively with Spo73p; mutants have defects in the PSM, aberrant spore wall formation and reduced PtdIns-phosphate pools in the PSM; contains three PH-like domains
codon start: 1
product: Spo71p
translation: MDSIVNVVEDDVKYAQRVTSFSSPQNANVKVFTIPRHSFTAFRLSYVSPTELSACSQVTLLGGIPKQWYADQNNQVWKLLTKISLRKVRKQSDMLRRYGYGTIYKKRVGKIPTALYLRKHFTWSYEDNTSIHNGHRLKEAEMEMKRTRSSPVQKSEYKLSLPRRCRSSSDQNFMRQELLKEKKSELSRNNSLPLIDTAQAVDIHPVLHEEDQENTNKRNKSLLSNLKRKDLGESKSISRKDYSHFDRIPSPSSARSVGETDFNYNREPSEDTLRYPDSIIEVTNRTSPAPNSILSRSGQFVNSNDLSDGFSTSNTINNVGLNANEKIFFNALQSMEKENLMLWKTSQKYGTYLDERRKSADAFQKRERGSCVDIGKLHSSHLPFINILPPWPTELTEEERIIHDRLASKHSHHIRKHVHNARNKTSCKIKDSVGTFLGMTNSLTNKATVKKRTGQILKKEKMLVMVKEAIQNKVPLPNFSENECFDTRVSERWKEYIVIARSTGRFDPPILLQFYRHRHIPEIEDISSIATKYHRNPLDFFLSRNCIVKFYSSLDKTISIQKPDKRLGGFIDESIEKKDELKHYSPIKIFILRCSSIRSSGRWYKFLLESLDRQLFTPAINLKIPLTEISIKINLNEIIFQKLIDLGKQEKDRLKICFLQRGYKIFQHPILRYFTVAILEKLKLAHYDYLIRKWDTENPVLGCALKRYDRLEWIPCDEDSLVTGIFAFCQSHLIQYRPIANRLRETKSLEGKCLKEPTPIEGFLIRLTDKYGSARTNFGKYSISTAYFFTCENLLFSMKAYRANPPLPIDSMIDDTSTEIEKEEIWKQWKKIPEVYEQQPYPLDTNDHIEWMNCQTTQSEYDSRDFYAFHCFHRRIDQILKTDNVIDLTEVKDIYQGTRTDYEADKIKYGVYKEASEIFWHRNYEIDDVSRSVINIETSNGLLLKLLATSATVAEEWVIKLKQMISYWKNKQREDTERLLKIRRSNAGLLMLNGEEETKIGENTLRWIVEHGRADEQTFNANGISLSRPLIQKGPLYQKPHKHSVFSKYYVVLISGFIVLFHCFHRSTTGFAKEVLEYAHYVTIPIDDCYLYSGTTTELDLLQRDRTFDEINYGSHALPRVYGDGWRSVEDESSRCFTLWFGTRRALSSNRLQKKGNEKQYTQDYGRQDNNIDPPSAPEADLNNSNVPSNTDKIHFTKKLGVSGKSMVFMARSRQERDLWVMSIYYELERLRRTASTSNSRNQTM
SIO_010081: YDR104C
subclass of: SO_0000673
so part of: YDR104C
location: complement(661173..664910)
location: region:661173-664910:-1
so has part: feature:661173-664910:-1:exon

NP_010389.3
type: Protein
SIO_000068: ncbiprotein

S000002511
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:661173-664910:-1:exon

YDR105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TMS1
locus tag: YDR105C
so part of: sequence
location: complement(<665349..>666770)
location: region:665349-666770:-1
so has part: feature:665349-666770:-1:exon
subclass of: SO_0000010

851682
type: Gene
SIO_000068: ncbigene

position:665349:-1
position: 665349
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:666770:-1
position: 666770
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:665349-666770:-1:exon

YDR105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TMS1
locus tag: YDR105C
product: Tms1p
transcript id: NM_001180413.3
SIO_010081: YDR105C
subclass of: SO_0000673
so part of: YDR105C
location: complement(<665349..>666770)
location: region:665349-666770:-1
so has part: feature:665349-666770:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:665349-666770:-1:exon

YDR105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TMS1
locus tag: YDR105C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:26928762|PMID:23836928]
experiment: EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]
note: Vacuolar membrane hypothetical protein; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
codon start: 1
product: Tms1p
translation: MGAVISLPVSMAGSFVASCFGGCCSNLVTKTASSLGSSSLGTRLLYAVWLLLNSLISWVSYSANKSILWPGKTCTGTGECGFFTVHRLNFALGCLHLILALVLTGVKSTNDVRAALQNSWWSLKFILYLCLIVLSFVIPNDFYIFFSKWVSVPSGAIFILVGLILLVDFAHEWAETCISHVESEDEDSSFWQRFLVLGTTSMYTASIIMTVVMYVMFCHQQCNMNQTAVTVNLILTVITLVLSVNPKIQEANPKSGLAQSSMVSVYCTYLTMSAMSSEPDDKMCNPLVRSSGTRKFSIILGSLFTFIAIAYTTTRAAANSAFQGTNTNGAIYLGNDIEYEGLGGQTRNQLRYEAIKQAVEEGSLPESALYDTAWLGTSSPTGAMDNQNDDERTGTKYNYTLFHVIFFLATQWIAILLTINVTQDDVGDFIPVGRTYFYSWVKIVSAWICYALYGWTVVAPAIMPDRFDYENYY
SIO_010081: YDR105C
subclass of: SO_0000673
so part of: YDR105C
location: complement(665349..666770)
location: region:665349-666770:-1
so has part: feature:665349-666770:-1:exon

NP_010390.3
type: Protein
SIO_000068: ncbiprotein

S000002512
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:665349-666770:-1:exon

YDR106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARP10
locus tag: YDR106W
so part of: sequence
location: <667004..>667858
location: region:667004-667858:1
so has part: feature:667004-667858:1:exon
subclass of: SO_0000010

851683
type: Gene
SIO_000068: ncbigene