Klebsiella aerogenes strain Ka37751 plasmid unnamed1, complete sequence.
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
Unexpected isolation of twenty-nine distinct MCR-1-producing Enterobacteriaceae isolates from one patient in three years
Submitted (22-JUL-2019) State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun, Hangzhou 310000, China
REFSEQ INFORMATION: The reference sequence is identical to\nCP041926.1.\nThe annotation was added by the NCBI Prokaryotic Genome Annotation\nPipeline (PGAP). Information about PGAP can be found here:\nhttps://www.ncbi.nlm.nih.gov/genome/annotation_prok/\n\n##Genome-Assembly-Data-START##\nAssembly Method :: SPAdes v. 3.10.2\nGenome Representation :: Full\nExpected Final Version :: Yes\nGenome Coverage :: 200x\nSequencing Technology :: PacBio Sequel\n##Genome-Assembly-Data-END##\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: NCBI RefSeq\nAnnotation Date :: 03/26/2023 01:53:25\nAnnotation Pipeline :: NCBI Prokaryotic Genome\n Annotation Pipeline (PGAP)\nAnnotation Method :: Best-placed reference protein\n set; GeneMarkS-2+\nAnnotation Software revision :: 6.4\nFeatures Annotated :: Gene; CDS; rRNA; tRNA; ncRNA\nGenes (total) :: 5,001\nCDSs (total) :: 4,879\nGenes (coding) :: 4,827\nCDSs (with protein) :: 4,827\nGenes (RNA) :: 122\nrRNAs :: 9, 8, 8 (5S, 16S, 23S)\ncomplete rRNAs :: 9, 8, 8 (5S, 16S, 23S)\ntRNAs :: 87\nncRNAs :: 10\nPseudo Genes (total) :: 52\nCDSs (without protein) :: 52\nPseudo Genes (ambiguous residues) :: 0 of 52\nPseudo Genes (frameshifted) :: 33 of 52\nPseudo Genes (incomplete) :: 22 of 52\nPseudo Genes (internal stop) :: 8 of 52\nPseudo Genes (multiple problems) :: 9 of 52\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
COORDINATES: ab initio prediction:GeneMarkS-2+
GO:0030255 - protein secretion by the type IV secretion system [Evidence IEA]
Derived by automated computational analysis using gene prediction method: GeneMarkS-2+.
COORDINATES: similar to AA sequence:RefSeq:WP_001425343.1
frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_000750964.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_000121741.1
COORDINATES: similar to AA sequence:RefSeq:WP_001694627.1
type II toxin-antitoxin system RelE/ParE family toxin
COORDINATES: similar to AA sequence:RefSeq:WP_000835774.1
TrbM/KikA/MpfK family conjugal transfer protein
COORDINATES: protein motif:HMM:NF022136.2
COORDINATES: protein motif:HMM:NF019064.2
COORDINATES: protein motif:HMM:NF013618.2
lytic transglycosylase domain-containing protein
COORDINATES: protein motif:HMM:NF016957.2
VirB3 family type IV secretion system protein
COORDINATES: similar to AA sequence:RefSeq:WP_001481831.1
frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: protein motif:HMM:NF016238.2
COORDINATES: similar to AA sequence:RefSeq:WP_000274524.1
TrbG/VirB9 family P-type conjugative transfer protein
COORDINATES: protein motif:HMM:NF015688.2
COORDINATES: similar to AA sequence:RefSeq:WP_001708009.1
GO:0043684 - type IV secretion system complex [Evidence IEA]
GO:0044097 - secretion by the type IV secretion system [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_000726934.1
type IV secretory system conjugative DNA transfer family protein
COORDINATES: similar to AA sequence:RefSeq:WP_001708008.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0008134 - transcription factor binding [Evidence IEA]
GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]
sigma 54-interacting transcriptional regulator
COORDINATES: similar to AA sequence:RefSeq:WP_001035590.1
GO:0019867 - outer membrane [Evidence IEA]
GO:0009297 - pilus assembly [Evidence IEA]; GO:0009306 - protein secretion [Evidence IEA]
PilN family type IVB pilus formation outer membrane protein
COORDINATES: similar to AA sequence:RefSeq:WP_001360347.1
COORDINATES: similar to AA sequence:RefSeq:WP_001401690.1
GO:0009297 - pilus assembly [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_000466225.1
COORDINATES: similar to AA sequence:RefSeq:WP_000974900.1
type II secretion system F family protein
COORDINATES: similar to AA sequence:RefSeq:WP_000095049.1
COORDINATES: similar to AA sequence:RefSeq:WP_001258095.1
COORDINATES: similar to AA sequence:RefSeq:WP_000934977.1
COORDINATES: similar to AA sequence:RefSeq:WP_000750525.1
shufflon system plasmid conjugative transfer pilus tip adhesin PilV
COORDINATES: similar to AA sequence:RefSeq:WP_000486721.1
COORDINATES: similar to AA sequence:RefSeq:WP_000572551.1
COORDINATES: similar to AA sequence:RefSeq:WP_001542050.1
COORDINATES: similar to AA sequence:RefSeq:WP_001708409.1
COORDINATES: similar to AA sequence:RefSeq:WP_012908955.1
COORDINATES: similar to AA sequence:RefSeq:WP_020314981.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003916 - DNA topoisomerase activity [Evidence IEA]
GO:0006265 - DNA topological change [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_000850858.1
COORDINATES: similar to AA sequence:RefSeq:WP_000666090.1
COORDINATES: protein motif:HMM:NF028536.0
COORDINATES: similar to AA sequence:RefSeq:WP_049589868.1
phosphoethanolamine--lipid A transferase MCR-1.1
COORDINATES: similar to AA sequence:RefSeq:WP_020315431.1
COORDINATES: similar to AA sequence:RefSeq:WP_000725934.1
plasmid mobilization relaxosome protein MobC
COORDINATES: similar to AA sequence:RefSeq:WP_000717859.1
COORDINATES: similar to AA sequence:RefSeq:WP_001542035.1
COORDINATES: similar to AA sequence:RefSeq:WP_000108794.1
COORDINATES: similar to AA sequence:RefSeq:WP_000207992.1
incomplete; partial in the middle of a contig; missing N-terminus and C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_000466318.1
type II toxin-antitoxin system HicB family antitoxin
COORDINATES: similar to AA sequence:RefSeq:WP_000833472.1
type II toxin-antitoxin system HicA family toxin
COORDINATES: similar to AA sequence:RefSeq:WP_000068545.1
COORDINATES: similar to AA sequence:RefSeq:WP_000680170.1
COORDINATES: similar to AA sequence:RefSeq:WP_000545933.1
COORDINATES: similar to AA sequence:RefSeq:WP_001132407.1
COORDINATES: similar to AA sequence:RefSeq:WP_000702243.1
COORDINATES: similar to AA sequence:RefSeq:WP_000814382.1
COORDINATES: similar to AA sequence:RefSeq:WP_020314678.1
COORDINATES: similar to AA sequence:RefSeq:WP_020314677.1
COORDINATES: similar to AA sequence:RefSeq:WP_000855123.1
COORDINATES: similar to AA sequence:RefSeq:WP_031587700.1
IS1380-like element ISEcp1 family transposase
COORDINATES: similar to AA sequence:RefSeq:WP_011091028.1
extended-spectrum class A beta-lactamase CTX-M-199
COORDINATES: similar to AA sequence:RefSeq:WP_016943399.1
incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_000151456.1
COORDINATES: similar to AA sequence:RefSeq:WP_001230709.1
COORDINATES: similar to AA sequence:RefSeq:WP_001401654.1
COORDINATES: similar to AA sequence:RefSeq:WP_001025391.1
COORDINATES: similar to AA sequence:RefSeq:WP_000532148.1
COORDINATES: similar to AA sequence:RefSeq:WP_001542021.1
COORDINATES: similar to AA sequence:RefSeq:WP_000125166.1
COORDINATES: similar to AA sequence:RefSeq:WP_004118124.1
COORDINATES: protein motif:HMM:NF010277.0
incomplete; partial in the middle of a contig; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_000841011.1
COORDINATES: similar to AA sequence:RefSeq:WP_001175215.1
COORDINATES: similar to AA sequence:RefSeq:WP_001326595.1
GO:0006351 - DNA-templated transcription [Evidence IEA]
CaiF/GrlA family transcriptional regulator
COORDINATES: similar to AA sequence:RefSeq:WP_001127357.1
COORDINATES: similar to AA sequence:RefSeq:WP_000753063.1
COORDINATES: similar to AA sequence:RefSeq:WP_000564242.1
COORDINATES: similar to AA sequence:RefSeq:WP_000964333.1
COORDINATES: similar to AA sequence:RefSeq:WP_000550720.1
COORDINATES: similar to AA sequence:RefSeq:WP_001243164.1
COORDINATES: similar to AA sequence:RefSeq:WP_001542015.1
COORDINATES: similar to AA sequence:RefSeq:WP_001360345.1
COORDINATES: similar to AA sequence:RefSeq:WP_000739144.1