Hepatitis C virus genotype 1, complete genome.
Viruses; Riboviria; Flaviviridae; Hepacivirus.
Triple decoding of hepatitis C virus RNA by programmed translational frameshifting
Subcellular localization and topology of the p7 polypeptide of hepatitis C virus
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
Submitted (07-AUG-2002) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JUN-1997) Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 63110-1093, USA
REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from AF009606.\nThe mature peptides have been annotated by the NCBI staff using the\ndata from current literature as well as other annotations available\nfor this virus.\nCOMPLETENESS: full length.
assembled from cDNA library representing a population of Hepatitis C virus genomes; viable virus can be reconstituted from this sequence
cleaved from polyprotein by signal peptidase; further processed to loose the C-terminal signal peptide and thereby to be released (as a smaller protein, p19c) from the endoplasmic reticulum membrane; viral capsid protein; reportedly involved in diverse processes, e.g. viral morphogenesis or regulation of host gene expression; p21c
viral envelope protein; product of cellular signal peptidase; forms a heterodimer with the E2 protein
viral envelope protein; product of cellular signal peptidase; forms a heterodimer with the E1 protein
product of cellular signal peptidase; integral membrane polypeptide; has a double membrane-spanning topology, with both its N and C termini oriented toward the extracellular environment
N-terminus is cleaved by a cellular signal peptidase; C-terminus is produced by the only known cleavage event mediated by the NS2-NS3 metal-dependent proteinase; membrane protein with 2 internal signal sequences; suggested type III membrane topology protein; inhibitor of CIDE-B-induced apoptosis
N-terminus is produced by the only cleavage in HCV polyprotein mediated by the NS2-NS3 metal-dependent proteinase; cleaves itself at the C-terminus; with the help of NS4A, mediates processing of all the other HCV non-structural proteins; physically and functionally interacts with the NS5B RNA polymerase; susceptible to inhibition by the N-terminal cleavage products of substrate peptides
membrane protein; negative regulator of the NS3-NS5B replication complex
phosphorylated; associated with interferon sensitivity
17-kDa frameshift protein F; some of the functions that were earlier attributed to the core protein may actually be mediated by F; similarly to HCV core and NS5A proteins, F is associated with the endoplasmic reticulum and, therefore, may play a role in HCV morphogenesis or replication; -2/+1 frameshift; although the exact location of the frameshift is unknown, it was mapped to codons 9 to 11 of the core protein coding sequence.