Cryptosporidium parvum Iowa II chromosome 8, whole genome shotgun sequence.
Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
Complete genome sequence of the apicomplexan, Cryptosporidium parvum
Submitted (06-MAR-2007) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (02-APR-2004) Veterinary Pathobiology, University of Minnesota, 1988 Fitch Ave., St. Paul, MN 55108, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence was derived from CM000436.
signal peptide, predicted secreted protein of cryptosprodidium-specific SKSR gene family
signal peptide, predicted secreted protein of cryptosprodidium-specific FGLN gene family
signal peptide, possible transmembrane domain near N
signal peptide, similar to putative purple acid phosphatase precursor
10 transmembrane domain, possible aa transporter
with domain similar to YL1 nuclear protein
CpTSP4; extracellular protien with signal peptide and 2 repeats of an apple domain followed by a TSP1 domain
DNA-directed RNA polymerase beta subunit
Mak5 pre-mRNA splicing RNA SFII helicase
carboxy-terminal region similar to exosomal 3'-5' exoribonuclease complex subunit; transcripts identified by EST
hypothetical protein with 6 transmembrane domains
similar to pantothenate kinase 4 and fumble
asparaginyl-tRNA synthetase (NOB+tRNA synthase)
putative vacuolar ATP synthase subunit E
possible secreted protein with long stretch of threonines, putative mucin
possible secreted protein with long stretch of threonines mucin
cleavage and polyadenylation specifity factor protein, CPSF metallobeta-lactamase
MRG/Alp3 like proteini with a chromodomain and an MRG domain
histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus
uncharacterized large low complexity coiled coil protein
hypothetical protein with 4 transmembrane domains
CpTSP12; extracellular protein with 1 TSP1 domain
CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1; phosphatidylinositol synthase; PtdIns synthase; PI synthase
ubiquitin-conjugating enzyme E2, putative
alpha/beta hydrolase superfamily protein
secrted alpha/beta hydrolase superfamiy protein
DNA replication repC1, AAA+ ATpase with a BRCT domain at the N-terminus
26S proteasome regulatory complex, subunit PSMD5
hypothetical protein, signal peptide, paralogs
large low complexity protein with repeats
with signal peptide containing protein with 2 cryptosporidium-specific paralogs
predicted secreted protein, signal peptide with several threonines, possible mucin
cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain
predicted secreted protein, 1 or more transmembrane domain, signal peptide
F11M21.28-like protein with 3 CCCH RNA binding domains involved in RNA metabolism
Prp5p C terminal KH. eIF4A-1-family RNA SFII helicase
26S proteasome regulatory subunit S10b like AAA+ ATpase
predicted membrane associated protein with 8 transmembrane domains
membrane associated protein with 8 transmembrane domains
coatomer protein complex subunit alpha, putative
DNA dependent DNA polymerase alpha subunit, inactive calcineurin like phosphatase subunit
transcription initiation factor TFIIB Sua7p; ZnR+2cyclins
CobW/nitrile hydratase activator like P-loop ATpase
Ydr449cp/Utp6p; small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA). HAT repeats
vacuolar membrane protein pep3, human vacuolar protein sorting 18-like protein with a metal binding domain at the C-terminus
small hypothetical protein conserved in plasmodium; similar to gi:23613649
orthologous to plasmodium protein, signal peptide plus 6 to 8 transmembrane domains; similar to gi:233509913
VPS13 like protein involved in vacuolar protein trafficking
STXBP/UNC-18/SEC1 syntaxin involved in golgi transport
NRAP like nucleolar RNA associated protein
ER/lumen protein retaining receptor (KDEL receptor), signal peptide plus 4 or more transmembrane domains
HBS1 eRFS. GTpase. (RNA metabolism; translation)
signal peptide plus His and thr repeats, signal peptide plus transmembrane domain or GPI anchor, predicted mucin
amino acid permease like integral membrane protein, signal peptide plus 11 transmembrane domain
E3A like HECT domain containing ubiquitin protein ligase
mitochondrial ADP/ATP-transporter, integral membrane protein with 4 transmembrane domains
uncharacterized protein with threonine repeats
DNA polymerase epsilon catalytic subunit
SEC24C-like component of COPII coatamer of ER-golgi vesicles
integral membrane protein with 8 transmembrane domains, likely plant origin
Smc like ABC ATpase involved in DNA repair
hypothetical protein, signal peptide, possible secreted protein
with glutamine rich C-terminus, plasmodium CG2 ortholog
topoisomerase VIA/SpoII nuclease subunit, toprim domain
DP-fucose transporter with 9 transmembrane domains
hypothetical protein, transmembrane domain at C-terminus
glycerol-3-phosphate acyltransferase family, possible plant origin, possible signal peptide plus 2 transmembrane domains
secreted alpha glucosidase like family 31 glycosyltransferase, signal peptide
nucleotide sugar transporter like integral membrane protein with 9 transmembrane domains
11x WD40 repeats containing protein of plant origin
RPR domain containing protein, present in proteins involved in mRNA splicing
bacterial type serine/tyrosine phosphatase
large protein with possibly 18 transmembrane domains
ubiquitin carboxyl terminal hydrolase domain that is fused to a MATH domain
S. cerevisiae YLR387c-like protein with 2x C2H2 like zinc fingers conserved across eukaryotes plus an apicomplexan-specific globular domain
cyclophilin type peptidyl-prolyl cis-trans isomerase
saccharomyces Yor006cp like protein conserved across euks and archaea
sugar phosphate permease with 11 transmembrane domains
sacsin like HSP90 chaperone domain, likely plant origin
DNA polymerase delta2, inactive calcineurin like phosphatase subunit
RAB acceptor, possible 2 or more transmembrane domains
partner of Nob1; Pno1p; Yor145cp like KH domain containing protein
related to and redundant with Elm1p and Pak1p in activating the SNF1 complex; Tos3p
NAD dependent dehydrogenase of possible bacterial origin
acetaldehyde reductase plus alcohol dehydrogenase (AdhE) of possible bacterial origin
Uba3p like ubiquitin activating enzyme E1
predicted secrete protein, paralog within GGC gene family of secreted cryptospordium proteins
signal peptide, possible ER retention motif
HxYxP motif containing repeats seen only in C. elegans F29G6.3b, signal peptide
hypothetical protein, signal peptide, predicted secreted protein
pelota/Dom34; pelota like RNA binding domain
40S ribosomal subunit protein S9, putative
E2F like domain containing transcription factor with the wHTH fold
Vps9p/ RAB5 like RAB GTpase binding protein involved in vacuolar sorting
belongs to the CED12/ELMO class proteins that in animals is involved in rearranging the cytoskeleton
predicted transmembrane domain, transmembrane domain within N-terminus
epsin like ENTH/VHS domain involved in endocytosis/vesicular trafficking
shares a domain with a conserved HREF motif with the CWF15 protein that is involved in mRNA splicing
NAD kinase involved in polyphosphate metabolism
actin-related protein Arp23 like WD 40 repeate protein
KRE33p like superfamily I ATPAse fused to an acetylase
span like RimI family protein amino acetyltransferase
OGG1 like 8-oxoguanine DNA glycosylase involved in DNA repair
POZ domain protein, related to tetramerization domain of K channel
RRP5 like protein involved in rRNA biogenesis with 7 S1 domains and 5 HAT repeats
hypothetical membrane associated protein with a signal peptide and a transmembrane domain near the carboxy-terminus
predicted membrane associated protein, signal peptide plus transmembrane domain or GPI anchor at C-terminus
membrane associated protein, signal peptide plus transmembrane domain or GPI anchor at
cation-transporting ATpase 2 with 8 transmembrane domains
human stromal cell-derived factor like secreted protein with 3 MIR domains, signal peptide + ER retention XDEL
shares a domain with poly(ADP) ribose glycohydrolases, some protein kinase A anchoring proteins and baculovirus HzNV Orf103, possible transmembrane domain within N-terminus
BRG1/brm-associated factor 53A like actin
hypothetical protein with a domain with conserved cysteines shared in dictyostelium, leishmania and plants
phosphatidylinositol glycan class O, integral membrane protein with signal peptide sequence and 12 or more transmembrane domains
uncharacterized protein with 5 transmembrane domain
brahma like protein with a HSA domain, SNF2 like helicase and a bromo domain
pyridine nucleotide/ NAD(P) transhydrogenase alpha plus beta subunits, duplicated gene, possible signal peptide plus 12 transmembrane regions
cold shock RNA binding domain of the OB fold
cyclophilin-RNA interacting protein, putative
CDC45 like protein, possible horizontal transfer
Sey1p like P-loop GTpase of the RHD3 subfamily with a transmembrane domain near C-terminus
transcription initiation factor IIF/ Rap30 like winged HTH
Ser/Thr protein kinase with MORN repeats at the N-terminus and a sterile alpha motif (SAM_ domain
hypothetical protein with possible SAP domain
hypothetical protein, signal peptide, 4 transmembrane domains
signal peptide plus possible transmembrane domain paralogs
with signal peptide, secreted protein, cryptosporidium-specific paralogs
hypothetical protein, signal peptide, membrane protein, transmembrane domain at C-terminus, paralogs
Cyclin dependent kinase regulatory subunit, putative
Cyclin dependent kinase regulatory subunit
sushi-domain containing secreted protein; with a signal peptide, low complexity region followed by a sushi domain
apicomplexan specific coiled coil protein
apicomplexan specific membrane protein, 4+ transmembrane domain
HRD1 like membrane associated RING finger containing protein signal peptide plus 6 transmembrane domains
mitochondrial serine hydroxymethyl transferase
cytosolic serine hydroxymethyl transferase
APG10/ Aut1p like like autophagocytosis protein involved in vacuolar transport
large protein with ortholog in plasmodium
secreted glucose methanol choline like oxidoreductase of the FAD dependent oxidoreductase like fold, signal peptide
hypothetical secreted protein, signal peptide
phenol 2-monooxygenase like FAD dependent oxidoreductase of plant origin in apicomplexans
NADPH:ferredoxin--NADP+ reductase with a rossman fold nucleotide binding domain and a 2Fe-2S ferredoxin domain
multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster at the C-terminus
Myb domain containing protein with ortholog in plasmodium
SNF2L ortholog with a SWI/SNF2 like ATpase and a Myb domain
pleckstrin homology (PH domain) containing protein
extracellular protein with a signal peptide, a mucin-like stretch of threonine residues and 6 notch domains; possible mucin
membrane associated DNAJ with 6 transmembrane domain, signal peptide
Yjr014wp density-regulated protein homolog; metal binding N terminal plus RNA binding domain Sui1
ERV41 like membrane associated protein involved in vesicular transport with a transmembrane region near the C-terminus
ferlin-like type II membrane associated protein with 5 C2 domains, transmembrane domain or GPI anchor at C-terminus
Vps60p /Vps20p like protein involved in vacuolar protein sorting
Eft2p GTpase; translation elongation factor 2 (EF-2)
cervesiae Yh1017wp/PTM1 like protein; signal peptide plus 7 pass transmembrane regions
NIC+MI domains containing protein. nucampholin/yeast Cwc22p like protein involved in mRNA splicing
SYG1/ ERD1 like integral membrane protein required for retention of ER lumen proteins, with 8-10 transmembrane domains
hypothetical protein, signal peptide, secreted protein
predicted membrane associated protein, transmembrane domain near C-terminus
membrane associated protein, transmembrane domain near C-terminus
Swr1p like SWI/SNF2 family ATpase with a HSA domain at the N-terminus probably involved in chromatin remodelling
proteasome activator p28/ Ki autoantigen
MRP like MinD family ATpase of the SIMIBI class of P-loop GTpases
protein phosphatase regulator like HEAT repeats containing protein that folds into a alpha-alpha superhelix
membrane associated FAD-dependent oxidase involved in disulfide bond formation in the ER, 2x transmembrane domain near C-terminus
ubiquitin C-terminal hydrolase of the cysteine proteinase fold
UvrD like super family I helicase involved in nucleotide excision repair, possible bacterial horizontal transfer
La domain fused to two RRMs (as in the La autoantigen) which is further fused to a C-terminal domain present in the plant DCL protein and the C-terminus of the alpha subunit of the plant RNA polymerase, involved in RNA metabolism
with possible cryptosporidium-specific paralog; transcripts identified by EST
phosphatidylinositol-4-phosphate 5-kinase, putative
phosphatidylinositol-4-phosphate 5-kinase
secreted bacterial type DHHB/UbiG like methyltransferase involved in ubiquinone/menaquinone biosynthesis, signal peptide
centromere associated Kip3p, kinesin like P-loop NTpase that belongs to the TRAFAC class GTpase superfamily
S. cerevisiae Ylr022cp like protein that has a C2H2 zinc finger and is a component of the exosome
highly conserved small protein, similar to translation initiation factor eIF-1A
PWI domain containing protein that is typically seen in spliceosomal proteins
S. pombe SPAC1687.04 like conserved eukaryotic protein that shares a domain with several MCM7, probably involved in DNA replication
splicing factor SRP40 like 2x RRM domains
S.cerevisiae Ssf2p/drosophila peter pan like protein that has an IMP4 domain at its N-terminus and is involved in rRNA processing
RNA polymerase II CTD/NL1 interacting protein like phosphatase
zincin/aminopeptidase N like metalloprotease
importin beta like ARM repeat alpha superhelix
methionyl-tRNA synthetase of possible bacterial origin
membrane associated protein with a RING finger, 4xtransmembrane domain
secreted protein with cysteine rich repeats and a mucin like threonine rich repeat, signal peptide
paralog within cryptosporidium specific WYLE gene family, within locus of WYLE gene members
paralog within cryptosporidium specific WYLE gene family, within locus of WYLE gene members; transcripts identified by EST
predicted integral membrane protein, 7-pass transmembrane domain
integral membrane protein, 7-pass transmembrane domain
niemann-Pick type C1 disease protein/ patched like cholesterol transporter of the SecD family, 12 transmembrane domain
RNA 3'-Terminal Phosphate Cyclase-like protein
acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis
D441/Mpe1p like protein with a zinc knuckle (C2HC) and PhD Zn finger domain
Yer119cp like amino acid transporter, 11 transmembrane domain
predicted membrane associated protein, signal peptide, transmembrane domain near C
membrane associated protein, signal peptide, transmembrane domain near C
Ubc6p like ubiquiting conjugating enzyme E2, possible transmembrane domain at C
secreted alpha beta hydrolase family protein, signal peptide, duplicated adjacent gene
membrane protein with signal peptide plus 12x transmembrane domains
Sub2p like superfamily II helicase involved in snRNP biogenesis
Na-dependent inorganic phosphate cotransporter with 12 transmembrane domains
hypothetical protein, signal peptide, predicted membrane protein, transmembrane domain near C-terminus
LepA like TRAFAC class GTpase, 2 transmembrane domain near C
eIF-2B gamma, eukaryotic translation initiation factor 2B subunit 3 that has a nucleotide diphospho sugar transferase at the N-terminus and a UDP N-acetylglucosamine acyltransferase at the C-terminus
MutS like ABC ATpase involved in DNA repair
large protein with 3x cNMP binding domain
Aps1p/AP17 like clathrin adaptor protein
26S proteasomal subunit S3; PINT domain containing protein
hypothetical protein, signal peptide + 5 transmembrane domains
PRP43 involved in spliceosome disassembly mRNA splicing
caltractin (centrin)-like, contains 3x EFh domains
secreted hydrolase superfamily, signal peptide
hypothetical protein, transmembrane domain
similar to CCAAT-box transcription factor
uncharacterized glycine-rich low complexity protein
uncharacterized protein with several coiled-coil regions
similar to HMG 1419611; Pf hit 23619511; transcripts identified by EST
FAD/NAD(P)-binding rossman fold oxidoreductase fused to a glucose-methanol-choline (GMC) oxidoreductase domain
similar to ubiquitin-like protein SMT3 (SUMO), Pf besthit 23613081; transcripts identified by EST
with signal peptide, possible plasmodium hits Py 23488316
ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold
hypothetical protein, possible transmembrane domain
WD40 repeat and RING finger domain-containing protein
translation initiation factor if-2 betam beta subunit ZnR
cell differentiation protein rcd1, putative
large protein with possible domain of nucleoporin, Non-repetitive/WGA-negative nucleoporin
hypothetical apicomplexan conserved protein with possible transmembrane region near the C-terminus
ISWI related chromatinic protein with an apicomplexan specific domain architecture composed of 3x PHD+SNF2 ATpase+2xPHD
7 pass integral membrane proteinwith FLHWFHH motif shared with fatty-acyl elongase
no plasmodium hits; transcripts identified by EST
apicomplexan specific Pf 23612804 and Py 23478322
hypothetical protein containing a signal peptide
DHHC family palmitoyl transferase with a signal peptide and 4 transmembrane domains
Dbp5p-like eIF4A-1-family RNA SFII helicase
large protein with possible central conserved domain
proteolipid subunit of the vacuolar ATpase
SSM4 like ring finger with a forkhead associated (FHA) domain (apicomplexan-specific architecture)
RNA pol II carboxy terminal domain phosphatase of the HAD superfamily with a BRCT domain at the C-terminus
extracellular protein with a signal peptide, kazal domain and mucin like low complexity repeats
large protein with 2 MYB domains plus low complexity; GA repeat and Q repeat at the C-terminus
signal peptide containing protein with central region possible conserved in plasmodium and wider conserved, transmembrane domain within C-terminus
putative clathrin assembly protein AP19, small subunit
clathrin assembly protein AP19, small subunit
PAN2 family 3'5' exonuclease, UBC hydrolase (inactive) plus nuclease
trehalose-6-phosphate synthase of likely plant origin
apicomplexan-conserved protein Pf 23619083 and Py 23490592; low complexity 1667 aa
complementary to 25S rRNA at position 2804; methylates base U
RagC like small GTpase of the Ras superfamily
hypothetical protein, possible conserved
starch binding domain containing protein, possible plant origin
articulin family protein, Pfs77 protein-related
hypothetical protein, possible transmembrane domain within N-terminus
similar to putative splicing factor, rrm domain
possible coated vesicle proteins, emp24/gp25L/p24 family, signal peptide, possible transmembrane domain at C-terminus
uncharacterized apicomplexan-specific protein
large protein with central conserved domain, possible BCRT domain
signal peptide, 4+ transmembrane domains
U2AG splicing factor U2AF U2snRNP auxilliary factor small subunit CCCh+RRM+CCCh-like
Srp101p GTpase. signal recognition particle receptor alpha subunit
integral membrane protein predicted amino acid permease, 11x transmembrane domains
Deg1p-like type II pseudouridylate synthase TruA
large protein with possible signal peptide and acidic plus glycine repeats
similar to myosin, possible signal peptide; transcripts identified by EST
with signal peptide, within telomeric locus of cryptosporidium-specific predicted secreted proteins
with signal peptide, his stretches, within telomeric locus of cryptosporidium-specific predicted secreted proteins
with signal peptide, within telomeric locus of cryptosporidium-specific predicted secreted proteins; transcripts identified by EST
with signal peptide, paralogs, within telomeric locus of cryptosporidium-specific predicted secreted proteins