Cryptosporidium parvum Iowa II chromosome 7, whole genome shotgun sequence.
Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
Complete genome sequence of the apicomplexan, Cryptosporidium parvum
Submitted (06-MAR-2007) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (02-APR-2004) Veterinary Pathobiology, University of Minnesota, 1988 Fitch Ave., St. Paul, MN 55108, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence was derived from CM000435.
calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands
Hat1-like acetyltransferase (histone acetyltransferase-like)
integral membrane protein with 6 transmembrane domains and possible ring domain
high affinity sulfate transporter-related
putative sortilin, SMART_VSP10 domain, possible signal peptide
sortilin, SMART_VSP10 domain, possible signal peptide
cAMP-dependent protein kinase regulatory subunit
hypothetical protein with signal peptide and transmembrane domain near C-terminus
hypothetical protein with signal peptide
RPR45-like archaeo-eukaryotic exosomal RNAse PH
conserved integral membrane protein with 4 transmembrane domains, possible plant or bacterial origin
protein with two motifs similar to flavin containing amine oxidases, no plasmodium ortholog
cell division control protein 28, putative
CpCCP2; extracellular protein with a signal peptide, ricin, discoidin, NEC, LCCL, 2 levanase and an apicomplexan-specific cysteine-rich repeat (apicA repeat)
similar to Gle1l protein, nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor
with 9 transmembrane domains and signal peptide; similar to endosomal endomembrane protein 70
similar to golgi protein; conserved Gly-Trp motif: GWGGKGLLGCDIAAGPLYDIP
protein with a conserved N-terminal region
protein with DEXDc plus ring plus HELICc; possible SNF2 domain
cyclin-dependent kinase-related kinase, putative
RIO-like kinase domain; N-terminal region conserved
putative cytidine diphosphate-diacylglycerol synthase; integral membrane protein with 7 or more transmembrane domains
cytidine diphosphate-diacylglycerol synthase; integral membrane protein with 7 or more
P-type ATpase 3; integral membrane protein with signal peptide and 12 or more transmembrane domains; possible MgtA, cation tranport ATpase.
malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase
lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase
cyclin'cyclophilin like peptidyl-prolyl cis-trans isomerase fused to WD40 repeats at the N-terminus'
hypothetical protein with signal peptide and 8 or more transmembrane domains
hypothetical protein wtih 9 transmembrane domains, possible apicomplexan-specific protein
Prp16p pre-mRNA splicing factor. HrpA family SFII helicase
t-SNARE domain followed by hydrophobic stretch
conserved in plasmodium, transmembrane domain or GPI at C; transcripts identified by EST
hypothetical protein with a signal peptide
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
PASILLA splice variant 3-like 2KH domains, transmembrane domain at C-terminus
protein phosphatase PP2A, calcineurin like phosphoesterase superfamily
large protein with possible conserved (animals and fungi) N-terminal and C-terminal regions
eIF-3A like translation initiation factor that has a WD40 repeat-containing beta propeller
hypothetical protein with 3 or more transmembrane domains
protein with 2 possible TPR domains, possible n-terminal acetyltransferase
splicing factor RRM domain containing protein; T22E16.120 SC35-like splicing factor
putative Sec61; signal peptide plus 9 transmembrane domain-containing protein
Sec61; signal peptide plus 9 transmembrane domain-containing protein
protein with MYND plus SET domains plus 5 Ank repeats
F27M3_19 plant like RRM plus AlkB domain containing protein
possible apicomplexan protein, with 2 possible EF hand domains in C-terminal half of protein, EF hand is conserved in plasmodium version
Imp3p-like 40S ribosomal protein S9. S4 RNA binding domain
apicomplexan conserved protein with 2 or more transmembrane domains
similar to Sm-X5. SM domain containing protein.
shares a domain with the CWFL/SRm300 family RNA binding proteins
this domain expanded in plasmodium; transcripts identified by EST
PRP2'MLEL1 maleless. DSRBD plus helicase (similar to animal versions)'
protein containing ringfinger+4xC2H2+littlefinger domains
Trp and Cys-rich motif similar to step II splicing factor SLU7
hypothetical protein containing a signal peptide
hypothetical protein, transmembrane domain near N-terminus
calcium/calmodulin dependent protein kinase with an EF hand N-terminal to the kinase domain and 4 calmodulin like EF hands at the C-terminus
extracellular protein with a signal peptide followed by a family 2 glycosyltransferase and ricin domains
casein kinase II, alpha subunit, putative
protein kinase with possible transmembrane region near N-terminus
with signal peptide and 2 cryptosporidium-specific paralogs, putative secreted protein
hypothetical protein with a possible transmembrane domain within N-terminus
protein with signal peptide and Sec14d domain, probably secreted
similar to bacterial SbmA transporter protein, 4 or more transmembrane domains, 4 paralogs in cryptosporidium
possible phosphodiesterase/alkaline phosphatase D, of possible plant or bacterial origin
ART-4 protein; PIN+Zn ribbon domains. involved in RNA metabolism
DHHC family palmitoyl transferase with a signal peptide and 4 transmembrane domains
nop15p/nopp34; nucleolar protein with 1 RRM domain
Ncl1p/MJ0026/YebU-like. SUN family RNA methylase
protein with signal peptide and 6 transmembrane domains
STOP repeat protein involved in microtubule stabilization (possible variant metal binding site at N-terminus)
nuclear pore protein RBP16/17 (RAN binding protein 16/17)
meiotic recombination protein DMC1-like protein
threonyl-tRNA synthetase (RNA binding domain TGS+HxxxH+tRNA synthetase)
secreted protein with the following architecture: signal peptide sequence Ric, disc, NEC, LCCL domain,levanase, apicA
P-type ATpase (calcium/phospholipid-transporter), 9 transmembrane domains
tRNA exportin type nuclear export protein
protein with BRIGHT domain like HTH domain at N-terminus
ALG1 like beta-1,4 mannosyltransferase with possible signal peptide
secreted UDP-N-acetylglucosamine pyrophosphorylase family protein, signal peptide
calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands
SMC4'SMC4, chromosomal ATpase with giant coiled coil regions'
P24 like gold domain protein, possible transmembrane region near C-terminus, signal peptide
possible plasmodium ortholog; transcripts identified by EST
coatomer SEC21 gamma subunit like (beta adaptin)
CDC68 like aminopeptidase family chromatinic protein (possible inactive enzyme)
membrane protein with multiple cysteines at the N-terminus.
No homologs in other organisms, signal peptide plus 4 transmembrane domains.
nuclear pore associated protein (NLP4) with N-terminal ubiquitin domain
derived version of the calcineurin phosphoesterase fold
mitochondrial processing peptidase, insulinase like metalloprotease
Pre-mRNA splicing factor SF3a. 2xSWAP domain protein
hypothetical protein, signal peptide, possible secreted protein
uncharacterized conserved protein, signal peptide
thioesterase of the a/b hydrolase superfamily, possible bacterial origin
hypothetical small protein, possible signal peptide
eukaryotic membrane protein with transmembrane domains near C- and N- regions
RRP45-like archaeo-eukaryotic exosomal rnase, PH domain
signal peptide, secreted low complexity protein
translation initiation factor eIF-5; Tif5p, ZnR+W2 domains
possible membrane associated transporter
TBC domain protein (small GTpase GAP), 3 transmembrane domains
hypothetical membrane protein with 3 transmembrane domains
large membrane protein with signal peptide and transmembrane domain near carboxy terminus
Sgd1p; NIC plus MI domains containing protein involved in RNA metabolism
AMSJ/WSAK like polysaccharide polymerase (glycosyltransferase family)
integral membrane protein with 10 transmembrane domains
POZ+kelch domain protein with kelch repeats at the C-terminus
serine/threonine protein phosphatase, putative
Low complexity protein with 1 transmembrane domain
ataxin2 related nudix domain protein (RNA processing phosphatase/ATpase domain)
ABC transporter with ATpase domain plus 3 transmembrane regions
regena domain protein (CCR-Not complex protein subunit 3), putative
regena domain protein (CCR-Not complex protein subunit 3)
ubiquitin-conjugating enzyme E2, putative
ortholog of kin17 (RNA metabolism proteins): a family of highly conserved zinc binding C-rich proteins with KOW domains
hypothetical large low complexity protein
cathepsin like thiol protease possibly membrane associated
uncharacterized protein with predicted coiled coil regions
26S proteasome regulatory subunit, inactive JAB domain protein
Abd1p; RNA (guanine-7-methyltransferase (cap methyltransferase)
DNA replication licensing factor MCM5 like AAA+ ATpase
phospholipid cytidyltransferase HIGH family
Low complexity protein witha potential C2C2 zinc ribbon
rhomboid family membrane associated protease, 7 transmembrane domain
membrane protein conserved in eukaryotes
gamma-tubulin complex associated protein
hypothetical protein, signal peptide, transmembrane domain near C-terminus
ER vesicle protein; Erv41p, transmembrane region near C terminus and possible N region transmembrane
eukaryote specific membrane proteins signal peptide plus 8 transmembrane domain
with 6 transmembrane domain; transcripts identified by EST
thioredoxin fold protein related to phosducin
DHHC family palmitoyltransferase, 4 transmembrane domains plus possible signal peptide
membrane associated protein with no close homologs, transmembrane domain or GPI anchor at C-terminus
with 4 transmembrane domains; transcripts identified by EST
cleft lip and palate family of eukaryotic membrane proteins (potential transporters) with 9 transmembrane domains
with conserved extensions that are present in plasmodium
Ced12 family of proteins that are conserved throughout eukaryotes
hypothetical low complexity protein perhaps membrane associated
hypothetical secreted protein, signal peptide, possible transmembrane domain near C-terminus
putative secreted cysteine rich protein, possible transmembrane domain near C, signal peptide
secreted cysteine rich protein, possible transmembrane domain near C, signal peptide
secreted alpha beta hydrolyse, signal peptide, secreted patatin like esterase (ralstonia best hits)
major facilitator (MFS) superfamily transporter containing 12 transmembrane domains
major facilitator superfamily transporter
large low comlexity protein, potential zinc ribbon
cytidylyltransferase (HIGH family) exon-1
similar to ribosomal protein L10/L1 family
hypothetical protein, signal peptide, possible 3 transmembrane domains
RPR domain protein (involved in RNA metabolism)
YjeF family of predicted nucleotide binding proteins
proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold
heat shock protein 90 (Hsp90), signal peptide plus ER retention motif
long chain fatty acyl diphosphate synthase
apicomplexan P36 family of proteins, appears to be a divergent HAD family phosphatase
cryptosporidium family of large secreted proteins (CpLSP) signal peptide, secreted, gene within locus of secreted protein genes
DNAJ domain protein sec63 ortholog, 4 transmembrane domains
calcium-dependent protein kinase 7 (CDPK)(CPK7)
cysteine rich protein with two potential transmembrane domain regions
eIF4A-1; eukaryotic translation initiation factor 4A-1; RNA SFII helicase
2*FF domain protein (phosphopeptide binding)
small nuclear ribonucleoprotein, putative
cryptopsoridial mucin, large thr stretch, signal peptide sequence
with carboxy terminus conserved in plasmodium sp.; similar to gi:23612840
protein disulfide isomerase, signal peptide, ER retention motif
alpha superhelical protein, divergent TPR like repeats, possible microtubule associated protein
Ssm4 ring finger fused to a forkhead associated (FHA) domain (apicomplexan specific architecture)
UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase, signal peptide
extracellular protein with a signal peptide followed by family 2 glycosyltransferase and ricin domains
ring domain protein, possible 4 transmembrane domains
cation-transporting P-type ATpase with 11 or more transmembrane domains
Sec61-gamma subunit of protein translocation complex, putative
Sec61-gamma subunit of protein translocation complex
RNA pol II carboxy terminal domain phosphatase of the HAD superfamily with a BRCT domain at the C-terminus
membrane associated transporter, 10 transmembrane domain
Low complexity protein with coiled coil regions
extracellular protein with a signal peptide and 4 SCP domains
very large secreted protein, signal peptide
myosin'unconventional myosin fused to an RCC1 domain (unique)'
conserved protein with YSHH motif. SOme fused to polo box.
secreted acid phosphatase (calcineurin family),signal peptide
family 2 glycosyl transferase, possible fragment
elongation factor EF1-gamma (glutathione S-transferase family)
T8M16_190 RRM protein of possible plant origin
signal peptide-containing protein with transmembrane domain
ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multispecific organic anion transporter; multidrug resist
ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene
gigantic extracellular protein with interesting sushi (9x) and archaeal protease type repeats having the domain architecture: signal peptide-CRYPB(3x)-sushi (9x)-archaeoglobus type repeats (2x)
U6 snRNA-associated Sm-like protein LSm5. SM domain
Mth1. SpoU superfamily - SPOUT methylase
abstrakt protein SF II helicase + Znknuckle C2HC (PA)
secreted mucin like glycoprotein, signal peptide, thr stretch
ring finger domain protein and 2 transmembrane domains
similar to glutathione S-transferase subunit
ABC transporter, amino acid transporter 12 transmembrane spanning subunit
CpFNPA, extracellular protein with a signal peptide, FN2 domain and an anthrax toxin-N-terminus like domain. starts at second Met with signal peptide following
signal peptide plus GPI anchored membrane protein with N-terminal multiple cysteines
complementary to 18S rRNA; methylates base C
membrane proteins related to the mechanosensitive ion channel
having plasmodium orthologs, 6x transmembrane domains
phosducin related thioredoxin fold protein
signal peptide plus GPI anchored membrane protein
ubiqutin C-terminal hydrolase of the cysteine proteinase fold
conserved 3 transmembrane domain membrane associated RING finger domain (shared by plants and apicomplexans)
shared with plasmodium 10 transmembrane domains
secreted glycosyltransferase, possible transmembrane domain near C-terminus
protein phosphatase 2A regulatory subunit (contains a conserved version of EF hands)
large uncharacterized low complexity protein
ubiquitin ligase with a HECT domain at the C-terminus
complementary to 18S rRNA; methylates base U
complementary to 25S rRNA; methylates base A
similar to dictyostelium SonA, yeast Dsk2 with a ubiquitin domain 2 STI1 motif and a UBA domain at its C-terminus
with 3 transmembrane domains near C- terminus, signal peptide
SET domain protein with MYND insert (Skm/BOP family)
protein disulfide isomerase, signal peptide plus ER retention motif
complementary to 18S rRNA; methylates base A
with a signal peptide or extensive hydrophobic N- terminus
hypothetical low complexity protein with coiled coil regions
A surface protein with 2 conserved cysteines
U1 small nuclear ribonucleoprotein A, rrm domain
deoxyuridinetriphosphatase, possible bacterial origin
eIF3 gamma/P40 with JAB/PAD domains; translation initiation factor IF-3 subunit 3
uncharacterized protein with coiled coil regions
2-phosphoglycerate kinase involved in 2,3 diphosphoglycerate synthesis (P-loop kinase, distorted P-loop)
methyltransfer with N-terminal ankyrin repeats
hypothetical protein, possible membrane protein
Translation initiation factor 2, alpha subunit(eIF2-alpha); S1-like RNA binding domain
structure-specific recognition protein 1 (SSRP1) (recombination signal sequence recognition protein)
hedgehog-type HINT domain protein, possible animal horizontal transfer, signal peptide
Rab geranylgeranyltransferase, alpha subunit
Cwf5-like with 2 ZnR domains (CCCH and RRM domains missing)
thioredoxin/PDI, cyanobacterial type, signal peptide plus 4 transmembrane domains
similar to u6 snRNA-associated sm-like protein
LigT, 2 H domain protein, involved in RNA processing
with a transmembrane domain near C-terminus, signal peptide
possible 2 transmembrane domains, low complexity protein
very large low complexity protein, probably membrane associated
with a transmembrane domain within N-terminus, signal peptide
with signal peptide, cryptosporidium-specific paralogs, GGC family of secreted cryptosporidium proteins
with one transmembrane domain, no close homologs
serine/threonine rich low complexity protein