Cryptosporidium parvum Iowa II chromosome 6, whole genome shotgun sequence.
Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
Complete genome sequence of the apicomplexan, Cryptosporidium parvum
Submitted (06-MAR-2007) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (02-APR-2004) Veterinary Pathobiology, University of Minnesota, 1988 Fitch Ave., St. Paul, MN 55108, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence was derived from CM000434.
hypothetical protein with signal peptide and cysteine rich region at the C-terminus
with signal peptide and cryptosporidium-specific paralogs
secreted protein with 3 cryptosporidium-specific paralogs, serine stretch at C terminus, possible mucin; transcripts identified by EST
hypothetical protein with signal peptide and proline stretch at C-terminus
similar to CAAX prenyl protease, 6+ transmembrane domain protein
hypothetical protein with 5 transmembrane domains
conserved protein with signal peptide and transmembrane domain or GPI anchor signal near C-terminus
disulfide-isomerase, signal peptide plus ER retention motif, putative ER protein
disulfide-isomerase, signal peptide plus ER retention motif ER protein
possible Na+/H+ and K+/H+ antiporter with 12 transmembrane domains, duplicated adjacent gene
synaptobrevin'synaptobrevin, adjacent duplicated gene'
hypothetical, possible apicomplexan-specific protein
hypothetical protein, possible G-patch domain
DNA replication licensing factor MCM6-like AAA ATpase
hypothetical protein with 4 transmembrane domains
Residue at location 646 has been changed from stop codon to Glu because of a possible sequencing error. Experiment evidence is needed to validate the annotation.
with signal peptide and 8 transmembrane domains, amino terminl region conserved in plasmodium; transcripts identified by EST
hypothetical protein with signal peptide and 4 transmembrane domains, possible apicomplexan conserved
Sgn1p-like RRM domain containing protein
with signal peptide and 7 transmembrane domains and possible ER retention motif, conserved in plasmodium
with signal peptide and 8 transmembrane domains
membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein
Low complexity protein having signal peptide and glycine-rich repeat at C-terminal region
alanyl-tRNA synthetase (with HxxxH domain)
inactive CPSFs Cft2p metallobeta-lactamase
hypothetical protein with possible transmembrane domain or GPI anchor signal at C-terminus
casein kinase II, alpha subunit, putative
putative membrane protein involved in ER to golgi transport, with 4 transmembrane domains and signal peptide
with possible conservation in plasmodium
secreted pepsinogen like aspartyl protease having a signal peptide
extacellular protein with a signal peptide, clostripain like caspase/hemoglobinase domain, notch domain and 2 EGF domains
conserved protein with possible C2 domain
ribonucleotide reductase small subunit, duplicated adjacent gene
protein with signal peptide plus Thr stretch, possible mucin
There is a long ORF next to the 5' end. Further experiment is neccesary to verify whether that ORF is another gene or part of cgd6_720.
putative transcription factor with central bZIP transcription factor domain
transcription factor with central bZIP transcription factor domain
protein phosphatase-1 regulatory subunit 7 alpha2
conserved protein with 6 transmembrane domain
CpTSP8,predicted extracellular protein with 3 TSP1 repeats, an EGF domain and a C-terminal transmembrane domain. adjacent TSP domain containing gene.
CpTSP9, extracellular protein with 3 TSP1 domains and an EGF domain
predicted secreted low complexity protein with a signal peptide
protein with 2 pleckstrin homology (PH) domains, previously described as a 41 kDa oocyst wall protein
shanti/Ykl100cp/Minor histocompatibility antigen H13-like; presenilin, signal peptide peptidase family, with 10 transmembrane domains and a signal peptide
thioredoxin; protein disulfide isomerase A6, signal peptide, possible transmembrane domain in C-terminal region
complementary to 25S rRNA at position 1237; methylates base A
SPAC25H1.04/CG16979-cterm -like; cysteine protease
with 2 transmembrane domains, signal peptide and Sec20 domain (Sec20 is a membrane glycoprotein associated with secretory pathway), possible ER retention signal.
26s protease regulatory subunit 8, putative
Pdr17p-like Sec14 domain containing protein
U1 snrp Snp1p. RRM domain containing protein
hypothetical protein with signal peptide
IscU-like NifU protein, iron-sulfur protein
protein with spectrin repeats, CG12008-like
Ygl231cp/CG11137-homolog, 3 transmembrane domain
cryptosporidium gp40/15; signal peptide plus possible GPI anchor signal sequence, crypto-specific paralogs
diphthine synthase; diphthamide biosynthesis methyltransferase
similar to phosphoethanolamine N-methylase like o-methylase
GTpase Grc3p-like Pre-mRNA cleavage complex
SCT1/Gpt2p-like glycerol-3-phosphate acyltransferase signal peptide plus 3 transmembrane domain
hypothetical protein with one or more transmembrane domain
ring finger, membrane associated, possible signal peptide
cryptosporidium CpTSP5, extracellular protein with signal peptide and two repeats of an apple and a TSP1 domain
hypothetical protein, possible conservation in apicomplexa
hypothetical protein, possible transmembrane domain near N-terminus
possibly plasmodium conservation (this domain is expanded in plasmodium)
hypothetical protein with 7 transmembrane domains
hypothetical protein with possible transmembrane domain within C-terminus
Hus1-like; mitotic and DNA damage checkpoint protein
pre-mRNA splicing factor ATP-dependent RNA helicase, putative
pre-mRNA splicing factor ATP-dependent RNA helicase
secreted protein with signal peptide, fringe-like glycosyltransferase domain and a WcaK like glycosyltransferase domain
protein with SET domain flanked by cysteine clusters plus a C-terminal PHD domain
LOC51622_Hs/CG14980-like; plant, animal and plasmodium group
cytoachrome c oxidase subunit III with 6 transmembrane domains
hypothetical protein with 6 transmembrane domains
possible histone mRNA hairpin-binding protein
apyrase; calcium-activated nucleotidase SCAN-1-like protein; signal peptide
exonuclease i/din7p-like; xeroderma pigmentosum G N-region plus xeroderma pigmentosum G I-region plus HhH2 domain
eukaryotic translation initiation factor 4 gamma; Nic domain containing protein
cryptosporidium CpTSP11; extracellular protein with a signal peptide and 3 TSP1-like domains
MJ1332/Ygr210cp-like GTP binding protein; GTpase OBG family plus RNA binding domain TGS
splicing factor U2AF U2 snRNP auxiliary factor large subunit; 3 RRM domains
similar to CB20_Hs 20 kDa nuclear CAP binding protein
cleavage and polyadenylation specificity factor 4-like; 3x Zn C3H1 domains
Tra1p-like; C-terminal FAT domain plus phoshoinositide 3-kinase domain; very large protein
Rab geranylgeranyl transferase beta / prenyltransferase; alpha/alpha toroid fold
phosphatidylinositol 3-kinase; PI3ka plus PI3Kc domains
protein with C2H2 Zn finger, ASR2B-like N- and C-terminus
cyclin M2-like membrane-associated protein with 4 transmembrane domains and 2 CBS domains
anaphase promoting complex subunit 10, putative
CG9286/Bcp1p/BRCA and CDKN1A-interacting protein isoform C-like
hypothetical predicted protein, unknown function
similar to leishmania 15426171 and trypanosoma 14250894 chagasin inhibitor of cysteine peptidase, signal peptide, possible bacterial or archaeal origin
ribonucleotide-diphosphate reductase large chain; RIR1; c-terminal PFL-like glycyl radical enzymes-like fold
membrane-associated protein with a family 1 glycosyltransferase domain and a ricin domain with 3 transmembraned domains near C-terminus
hypothetical protein with a signal peptide
hypothetical protein with possible transmembrane domain near C-terminus
YbiN-like RNA methylase (NPPY variety; HemK family)
transmembrane protein with 6 transmembrane domains
integral membrane protein with signal peptide and 13 transmembrane domains
AMP-activated protein kinase beta chain (has isoamylase N-terminal domain)
cdc39p protein-like; C-terminal Not1, CCR4-Not complex component; Not1
adaptin AP complex subunit alpha; ARM repeats
CpCOWP1, oocyst wall protein with type I and type II cysteine-rich repeats
hypothetical protein, conserved cysteine residues, possible transmembrane domain or GPI anchor at C-terminus
hypothetical protein with a C-terminus transmembrane domain
conserved hypothetical multi-pass transmembrane protein, possible ion transporter
complementary to 25S rRNA at position 2736; methylates base U
Fun12p GTpase; translation initiation factor IF2
membrane-associated protein with 6 transmembrane domains possible apicomplexan conserved, duplicated adjacent gene
diphtamide biosynthesis; OVCA1/DPH2 protein-like; AE group
protein with N-terminal apicomplexan-specific globular domain plus PHD domain
Hca4p helicase DBP4 (helicase CA4). EIF4A-1-family RNA SFII helicase
hypothetical membrane-associated protein with 12 transmembrane domains
hypothetical protein with signal peptide and 12 or more transmembrane domains
Cut4/Apc1p/TSG24 family protein; meiotic check point regulator and 26S proteasome regulatory complex; PC-rep repeats
CpTSP6 extracellular membrane-associated protein with a signal peptide, an apple domain, TSP1 domain and a C-terminal transmembrane domain
multi-domain chromatin protein with WD40 repeats, bromodomain and PHD domain
mitochondrial carrier protein, 4 transmembrane domain
vacuolar protein sorting protein 33a; Sec1/syntaxin binding protein 2-like; neuronal Sec1 fold
mRNA capping enzyme; RNA guanylyltransferase Ceg1p
possible CutA1 divalent ion tolerance protein
CG7988/YLR412w homolog; conserved GXG and D and a PHC; possible peptidase
hypothetical protein having 6 transmembrane domains
thioredoxin (quiescin Q6 like) having signal peptide and 12 transmembrane domains
CCR4-NOT transcription complex, subunit 2; NOT2. C terminal Not2/Not3 domains
hypothetical protein with possible signal peptide
tRNA delta(2)-isopentenylpyrophosphate transferase, putative
tRNA delta(2)-isopentenylpyrophosphate transferase
histone acetyltransferase (MYST family); chromo domain + C2H2 domain
ERCC1 excision repair 1; C-terminal HhH domain
vesicle-associated membrane protein,MSP (major sperm protein) domain, transmembrane domain or GPI at C
complementary to 25S rRNA at position 2769; methylates base U
hypothetical protein with 12 transmembrane domains
macrophage infectivity potentiator (MIP);FKBP peptidyl-prolyl cis-trans isomerase-like fold, signal peptide + ER retention motif
Low complexity protein, possible apicomplexan conserved
hypothetical protein having a signal peptide and transmembrane domain within C- terminus
protein with signal peptide plus possible GPI signal or transmembrane domain at C-terminus
RRM domain containing protein; T22E16.120 Sc35-like splicing factor
2 SAM dependent methyltransferase; S-adenosyl-L-methionine-dependent methyltransferases + spermidine synthase (SAM dependent methyltranferase)
splicing factor 3a 66kD; N-terminus C2H2 domain
sucrose-phosphatase-like HAD superfamily hydrolase
protein with possible stromal antigen (SA/STAG) domain
large low complexity with PFL0360c_pfal like Znfinger
Bax inhibitor-1 (BI-1). integral membrane protien with 6 or more transmembrane domains
tyrosyl-tRNA synthetase (tyrosyl-tRNA ligase; TyrRS). class-I aaRS
hypothetical protein with conserved cysteines as in riboflavin-binding protein precursor (RBP), contains signal peptide plus possible GPI anchor
hypothetical protein with 8 transmembrane domains
dual specificity phosphatase, signal peptide
protein with sec7+ TBC domains (domain in Tre-2, BUB2p, and Cdc16p. probable Rab-GAPs)
with short region conserved in plasmodium
suppressor of lin-12; membrane associated Sel1/tpr-like repeats transmembrane domain near C-terminus
Gpi16p/PIG-T/SPBC1604.15 family; glycosyl phosphatidyl inositol 16 signal peptide and transmembrane domain or GPI anchor
possibly conserved in plasmodium (MAL1p1.50_pfal)
26S proteasome-associated Mov34/MPN/PAD-1 family. JAB domain.
glycogen branching enzyme (1,4-alpha-glucan branching enzyme)
DNA-directed RNA polymerase III C1 subunit
Yir323cp/Cwc24 p family; CCCH+ringfinger domains
membrane associated protein with a SPX domain (SYG1, Pho81 and XPR1) domain at the N-terminus and a vtc1p domain at the C-terminus. 3 transmembrane domains near the C-terminus.
hypothetical protein with transmembrane domain
possible zinc finger and possible FYVE domain
WD40 repeats; ytm1 homolog; transcripts identified by EST
Erf1 eukaryotic translation termination factor 1; N-terminal RNAseH plus pelota domain containing protein
membrane associated protein with 2 transmembrane domains at the N-terminus and a phosphatidylinositol 4-kinase domain at the C-terminus
tubulin, gamma tubulin complex protein 3
translation initiation factor EIF-2B epsilon subunit
EBNA1 binding protein 2; nucleolar protein p40
hypothetical protein with possible 4 or more transmembrane domains
MJ0041-family pseudouridylate synthase; Zn finger +thump + Psusyn
myotubularin related protein 1, C-terminus protein tyrosine/serine phosphatase, catalytic domain
hypothetical protein with 3 or more transmembrane domains
26S proteasome regulatory subunit Rpn6-like; PINT domain containing protein
hypothetical predicted WD-40 repeat protein, unknown function
secreted protein with ankyrin repeats, signal peptide plus transmembrane domain or GPI anchor
protein disulfide isomerase; secreted protein with thioredoxin, signal peptide plus ER retention motif
signal peptide, large secreted protein with N terminal ankyrin repeats + 8+ transmembrane domain
hypothetical, PF13_0020_pfal-like; PUG (domain in protein kinases, N-glycanases and other nuclear proteins) + UBX (domain present in ubiquitin-regulatory proteins)
large extracellular protein with a signal peptide, apple domain and a transmembrane region
1,4-alpha-glucan branching enzyme; alpha-amylase; glycogen brancing enzyme
possible transmembrane protein with 5 transmembrane domains
hypothetical membrane protein with signal peptide and transmembrane domain
glyceraldehyde 3-phosphate dehydrogenase
NUDIX domain protein; mRNA cleavage factor-like protein Im like, plant+animal group
membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain
HOI-POLLOI protein; U4/U6.U5 snRNP component; Snu13p; pelota RNA binding domain containing protein
hypothetical integral membrane protein with 12 transmembrane domains
mitochondrial carrier protein MRS2 with 2 transmembrane domains
pleckstrin homology (PH) domain containing protein
glutaredoxin-like protein; 2 thioredoxin folds
hypothetical protein having a signal peptide
uncharacterized apicomplexan-specific protein
lysophospholipase homolog; alpha/beta-hydrolase fold
dre2p/CG4180 homolog; family specific Znribbon
60S ribosomal protein L10, alpha/beta hammerhead
protein phosphatase 2B catalytic subunit, calcineurin like phosphatse superfamily
hypothetical protein containing a signal peptide
large protein having a MATH plus possible UBC hydrolase plus type I pseurousyn plus hexapeptide
26S proteasome regulatory subunit 7 (RPT1)-like. AAA atpase
hypothetical protein having a signal peptide and 4 transmembrane domains
SPBC24E9.10-like. RRM domain protein, no PWI domain.
phosphatase subunit gene g4-1; of possible animal origin; EF-hand, calcium binding domains
proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase)
DNA polymerase delta catalytic subunit. DNAQ-like 3'-5' exonuclease; RNAseH fold
hypothetical protein with transmembrane region near N-terminus
possible apicomplexan-specific, small protein
hypothetical low complexity protein with signal peptide
U2 snRNP. Hsh49p, RRM domain containing protein
hypothetical low complexity multi-pass transmembrane protein
with 5 transmembrane domains, plasmodium homologue PF14_0593_pfal
telomeric DNA binding protein; SANT DNA-binding domain
hypothetical protein with transmembrane domain near C-terminus
with a signal peptide and 4 transmembrane domains
UBP_znfinger+UBA; UBP5 like deubiquitinating enzyme with a UB hydrolase domain and two UBA domains at the C-terminus
glutamate synthetase, possible bacterial origin, beta-grasp+glutamate synthase catalytic domain
RNA polymerase III C34 subunit; rpc34p ortholog
5kows transcription initiation protein SPT5
Prp9p-like splicing factor 3a subunit 3 snRNP. C-terminal C2H2
hypothetical protein with 6 transmembrane domains and signal peptide
splicing factor 3B subunit1-like HEAT repeat containing protein
similar to cell cycle control protein cwf2
hypothetical low complexity protein with 2 possible transmembrane domains
predicted degraded Zn-finger +bbox Zn finger protein
degraded Zn-finger +bbox Zn finger protein
serine protease, subtilase family, signal peptide
PRP19 non-snRNP sliceosome component required for DNA repair
nucleolar protein GU2. eIF4A-1-family. RNA SFII helicase
cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus
transporter protein with conserved Zn ribbon C11C7CxxC
with 9 transmembrane domain; similar to the plasmodium chloroquine resistance transporter, CRT.
F11M21.28-like protein with 3 CCCH RNA binding domains, involved in RNA metabolism
beta-adaptin AP complex subunit-related; ARM/HEAT repeat protein
hypothetical protein with 2 or more transmembrane domains
serine/threonine-protein kinase, putative
Hsp60; GroEL-like chaperone (ATpase), predicted mitochondrial
predicted peptidase of the alpha/beta-hydrolase fold
peptidase of the alpha/beta-hydrolase fold
phosphoprotein phosphatase 2A 65K regulatory chain-like with HEAT repeats
ribophorin I -like, putative dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67kDa subunit precursor, signal peptide plus transmembrane domain at C-terminus
ribophorin I -like dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67kDa
GroEL-like chaperone (ATpase); T-complex protein 1
beta subunit homolog, tcp-1 chaperonin family
multi-pass transmembrane protein, putative
large hypothetical protein with possible signal peptide
protein with two PHD Zn fingers that is probably involved in chromatin function
ERGIC-53-like mannose binding lectin that is a type I membrane protein, transmembrane domain near C, signal peptide
hypothetical protein with conserved carboxy terminal region (KIAA1078 protein)
hypothetical protein having a transmembrane domain within N-terminus
transcription elongation factor, SPT6-like
ABC transporter ATpase with 2 AAA domains
with signal peptide, member of the cryptosporidium HCD gene family
large protein with signal peptide and cryptosporidium paralog (cgd6_5330)
protein with signal peptide plus thr stretch, cys rich, possible mucin
signal peptide plus thr stretch, charged repeats, likely mucin
hypothetical protein, signal peptide plus transmembrane domain or GPI anchor
hypothetical protein, signal peptide, paralogs
with a signal peptide, cryptosporidium-specific FGLN gene family member
hypothetical protein, signal peptide, transmembrane domain with N-terminus
cryptosporidium MEDLE family of secreted proteins, signal peptide, domain similar to daxx, KOG2243
cryptosporidium MEDLE family of secreted proteins, domain similar to KOG0943, predicted ubiquitin-protein ligase/hyperplastic discs protein, HECT superfamily
telomeric insulinase-like protease with signal peptide