Zymoseptoria tritici IPO323 chromosome 2, whole genome shotgun sequence.
Zymoseptoria tritici IPO323 (Mycosphaerella graminicola IPO323)
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes; Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis
Submitted (06-FEB-2020) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (18-MAY-2011) US DOE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598-1698, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CM001197.\nURL -- http://www.jgi.doe.gov/Mgraminicola\nJGI Project ID: 4000758\nThe DNA was provided by G.H.J. Kema (gert.kema@wur.nl)\nThe strain is available from Fungal Biodiversity Center,\nhttp://www.cbs.knaw.nl\nContacts: Stephen B. Goodwin (sgoodwin@purdue.edu)\n Gert H. J. Kema (gert.Kema@wur.nl)\n Igor Grigoriev (ivgrigoriev@lbl.gov)\nAssembly and annotation done by JGI.\n\n##Genome-Assembly-Data-START##\nAssembly Method :: JAZZ v. 1.0\nAssembly Name :: MYCGR v2.0\nGenome Coverage :: 8.9X\nSequencing Technology :: Sanger\n##Genome-Assembly-Data-END##\n\n##Metadata-START##\nOrganism Display Name :: Mycosphaerella graminicola IPO323\nGOLD Stamp ID :: Gi00795\n##Metadata-END##\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
culture from epitype of Zymoseptoria tritici
Protease. Similarity to M28 s but lacking good match to pfam domain PF0489. Has PA domain (Pfam: PF02225 Protease-associated).
putative FRE ferric reductase-like transmembrane component
Shows sequence similarity to FRE proteins of S. cerevisiae. These proteins are involved in iron uptake. They are ferroxidase(FET)-dependent reductases.
ABC transporter, ABC-C family, MRP type. TC3.A.1.208.These transporters mainly transport conjugated compounds and can be involved in metal resistance. This model is located in area containing a ferric reductase a copper transporter suggesting role in metal sensitivity.
predicted involved in secondary metabolite biosynthesis
P450 putatively acting on a polyketide metabolite. This model appear to be part of a PKS cluster. Comparison with characterized p450s did not yield highly significant matches. Multiple seq alignment and NJ analysis clustered this model with the following models: E_GW.14.17.1 (in a PKS cluster) and GW.1.2615.1.
Multicopper oxidase laccase with similarity to S. cerevisiae FET3 protein. Possible role in Iron uptake as a ferroxidase.
ketoacyl synthase domain-containing protein
orphan ketoacyl synthase domain similar to those in polyketide synthase genes involved in secondary metabolite biosynthesis
ABC transporter, ABC-C family, MRP type. TC3.A.1.208.These transporters mainly transport conjugated compounds and can be involved in metal resistance. Located in region harbouring a.o. 2 putative multicopper oxidases, a PKS, a CytP450 monoxygenase, a monoxygenase.
putative pyridine nucleotide-disulfide oxidoreductase
Similar to GliT (gliotoxin biosynthesis).
P450 putatively involved in the biosynthesis of a gliotoxin-like compound.
This protein is part of a gene cluster closely resembling the gliotoxin cluster found in A. fumigatus
Putative glutathione S-transferase similar to GliG (gliotoxin biosynthesis). This protein is part of a gene cluster closely resembling the gliotoxin cluster found in A. fumigatus.
O-methyltransferase similar to SirM and GliM. This protein is part of a gene cluster closely resembling the gliotoxin cluster found in A. fumigatus.
aminocyclopropane-1-carboxylate synthase-like protein
no ESTs for PKS6 but yes for NRPS4 that is part of presumed secondary metabolite gene cluster
Predicted polyketide synthase involved in secondary metabolite biosynthesis
Non-ribosomal peptide synthase, possibly associated with a sirodesmin/gliotoxin-like pathway; NRPS4 non-ribosomal peptide synthase, unknown product
Kynureninase. L-tryptophan catabolism: kynurenine => anthranilate + L-alanine+ H20.
PHOSPHOGLUCOMUTASE; glucose phosphomutase; phosphoglucose mutase
TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters
Actin-related protein; similar to the Saccharomyces cerevisiae ARP5 protein which is localized predominantly to the nucleus during interphase and may be involved in chromatin remodeling
serine/threonine protein kinase, CMGC family, CDC2/CDK subfamily
Alpha-amylase (Precursor possibly) (Signal P secreted)
Shows high sequence similarity to sidA of E. nidulans. sidA encodes an L-ornithine 5-monooxygenase allows L-ornithine to be used for the synthesis of siderophores. Important for iron uptake
ABC transporter, ABC-B family, MDR (II.2) type. TC3.A.1.201. In the yeasts S. cerevisiae and S. pombe these transporters are involved in secretion of mating pheromone.In other fungi they function as MDR transporters. Shows sequence similarity to AtrH of E. nidulans.
putative Non-ribosomal peptide synthetase
Shows sequence similarity to putative sidC of A. pullulans and S. pombe, and the known sidC of E. nidulans. This protein encodes a Non-ribosomal peptide synthetase involved in the biosynthesis of ferricrocin Fuarinine C and triacetylfusarinine C, siderophores involved in Iron uptake.
phosphotransferase activity, alcohol group as acceptor
SNF2 family DNA-dependent ATPase domain-containing protein
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
High-mobility group non-histone chromatin protein
1,2-Alpha-Mannosidase (Signal P secreted) (Glycosyl Hydrolase 47)
possible transposase or transposase fragment.
Putative . This model is clutered with other quinic acid utilization genes.
This enzyme is part of the beta-ketoadipate pathway. It uses cathecol as a substrate to produce muconate.
Similar to inositol monophosphatase. Quinate utilization cluster
Putative quinate 5-dehydrogenase. This model is part of a quinate utilization gene cluster.
Putative . This model is clustered with other quinic acid utilization genes.
Similar to qutH a putative found within the Aspergillus nidulans and fumigatus quinic acid utilization clusters, but absent in N. crassa.
Putative (DHS dehydratase). This model is a fragment. User model BDD_estExt_gwp_gw1.C_21724 should replace this one. This gene is part of a quinic acid utilization cluster.
Putative repressor of the quinate utilization genes. This model is clustered with other quinic acid utilization genes.
phosphotyrosine-specific Ptp2-like protein
Phosphotyrosine-specific protein phosphatase related to yeast Ptp2 involved in the inactivation of mitogen-activated protein kinase (MAPK) during hyperosmolarity conditions and dephosporylates Hog1p MAPK, regulates its localization.
Transcription factor C2H2 family (Pfam PF00096 domain). Con7p-like (Magnaporthe grisea implicated in appressorium morphogenesis/growth in planta).
P450 with unknown function. Comparison with characterized P450s did not yield highly significant matches
This model shows some similarity to GliN, a gene part of the gliotxin cluster.
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; putative homolog of Saccharomyces cerevisiae ARP9, a subunit of the chromatin remodeling Snf/Swi complex
CMGC family, dual-specificity tyrosine regulated kinase
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; putative homolog of Saccharomyces cerevisiae ARP8
belongs to Glycosyl transferase, family 2
ras like small GTPase with homology to rho2 from S. cerevisiae
nuclear protein SNF4, regulatory protein CAT3
Mammalian AMP-activated protein kinase and yeast SNF1 protein kinase are the central components of kinase cascades that are highly conserved between animals, fungi, and plants. The AMP-activated protein kinase cascade acts as a metabolic sensor or fuel gauge that monitors cellular AMP and ATP levels because it is activated by increases in the AMP:ATP ratio.
MgPP2CL-1, protein phosphatase 2C-like protein 1
Peptidase M24 (Pfam:PF00557) with predicted signal peptide.
putative major facilitator superfamily transporter
MFS-MDR transporter belonging to the DHA1 subfamily. These type of MFS transporters are implicated in MDR
ABC transporter, ABC-C family, MRP type. TC3.A.1.208.These transporters mainly transport conjugated compounds and can be involved in metal resistance.
citrate (Si)-synthase; (R)-citric synthase; citrate condensing enzyme; citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetyl-CoA]; citrate oxaloacetate-lyase, CoA-acetylating; citrate synthetase; citric synthase; citric-condensing enzyme; citrogenase; condensing enzyme; oxaloacetate transacetase; oxalacetic transacetase
Histone deacetylase complex protein; Sin3-associated polypeptide
Beta-Mannosidase (Glycosyl Hydrolase Family 2)
hypothetical protein, peptidase S10 superfam protein, potential serine carboxypeptidase, similar to carboxypeptidase Y cpy (gi|145240681|ref|XP_001392987.1|)
glyceraldehyde-3-phosphate dehydrogenase
(phosphorylating); triosephosphate dehydrogenase; dehydrogenase, glyceraldehyde phosphate; phosphoglyceraldehyde dehydrogenase; 3-phosphoglyceraldehyde dehydrogenase; NAD-dependent glyceraldehyde phosphate dehydrogenase; glyceraldehyde phosphate dehydrogenase (NAD); glyceraldehyde-3-phosphate dehydrogenase (NAD); NADH-glyceraldehyde phosphate dehydrogenase; glyceraldehyde-3-P-dehydrogenase; GO:0005737:cytoplasm GO:0005622:intracellular
Ca2+/calmodulin-dependent protein kinase
P450 with unknown function. Comparison with characterized p450s did not yield highly significant matches. purpurea. Similarities with these P450s was found by multiple seq alignment and NJ cluster analysis.
ABC transporter domain-containing protein
Non-transporter ABC protein belonging to the NAP (non-intrinsic ABC protein) subfamily (cluster VI). This group consists of a single cytoplasmic NBF-domain.
fructose-bisphosphate aldolase; aldolase; fructose-1,6-bisphosphate triosephosphate-lyase; fructose diphosphate aldolase; diphosphofructose aldolase; fructose 1,6-diphosphate aldolase; ketose 1-phosphate aldolase; phosphofructoaldolase; zymohexase; fructoaldolase; fructose 1-phosphate aldolase; fructose 1-monophosphate aldolase; 1,6-Diphosphofructose aldolase; SMALDO; GO:0005737 cytoplasm; GO:0005622 intracellular
Phosphatidylinositol synthase Lipid transport and metabolism
Shows strong sequence similarity to FET3 and FET5 of S. cerevisiae. These proteins are ferroxidases involved in iron uptake.
TOR2 phosphatidylinositol 3 and 4-kinase
MFS-MDR transporter belonging to the DHA2 subfamily. These type of MFS transporters are implicated in MDR and secretion of fungal secondary metabolites.
TGF BETA RECEPTOR ASSOCIATED PROTEIN RELATED
SNF2 family DNA repair and recombination protein
SNF2 superclass family protein, putative homolog of the Saccharomyces cerevisiae DNA repair and recombination protein RAD26
electron-transferring-flavoprotein dehydrogenase
serine/threonine protein kinase, CMGC family
catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
large subunit of alpha-aminoadipate reductase
alpha-aminoadipate reductase; involved in lysine biosynthesis. domains for nucleotide binding,Phosphopantetheine. Related to non-ribosomal peptide synthetases.
hexokinase; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; cell_comp: GO:0008372;cellular component unknown
Probable membrane protein with 3 transmembrane regions.
proteasome regulatory particle subunit RPT5
Hydrophobin. Similar to Class II hydrophobins
sensor histidine kinase/response regulator
Similar to Saccharomyces cerevisiae HMT1, a
P450 monooxygenase with unknown function. Comparison with characterized p450s did not yield highly significant matches
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis
Putative homolog of Saccharomyces cerevisiae RVB2, an essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex
p450 potentially involved in the degradation of fatty acids and/or alkanes. Multiple seq alignment followed by NJ analysis clustered this model with gi41079162; gi3395458, gi29469881, gi70984521 (alkane or fatty acids monoxygenases), and the models ESTEXT_GWP_GW1.C_110666, E_GW.6.936.1., ESTEXT_FGENESH2_PG.C_40295, ESTEXT_FGENESH2_PM.C_50060, ESTEXT_GWP_GW1.C_90605.
Beta-Galactosidase (Lactase) (Glycosyl Hydrolase Family 2)
Non transporter ABC protein, ABC-F family, GCN / EF3 type. EF-3 Elongation factor 3 ABC proteins are cytosolic proteins required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site.
Shows sequence similarity to Bet1 of S. cerevisiae. Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
Conserved hypothetical protein with signal-peptide
Putative homolog of Saccharomyces cerevisiae Bre2, a subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
Peptidase M24 (Pfam:PF00557) seems to lack a signal peptide.
Histone deacetylase (RPD3/HDA1 superfamily); similar to the Saccharomyces cerevisiae HAT1 protein which is the putative catalytic subunit of a class II complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer
hypothetical conserved protein with signal peptide
1,4-Alpha-Glycogen Branching Enzyme (Glycosyl Hydrolase Family 13)
eukaryotic translation initiation factor 6
putative ER lumen retaining receptor protein
proteasome regulatory particle subunit RPN8
Probable CSN6 from signalosome Cop9 complex
Dolichyl-phosphate-mannose-protein mannosyltransferase 2
Reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.
DNA-directed RNA polymerase III subunit RET1
fungal transcriptional regulatory protein
Alpha-L-Arabinofuranosidase (Precursor Possibly) (Glycosyl Hydrolase Family 62) (Signal P secreted)
histone H3 methyltransferase complex and RNA cleavage factor II complex, subunit SWD2
Putative homolog Saccharomyces cerevisiae SWD2, a COMPASS (Set1C) complex, which methylates ubiquitinated histone H3 on lys 4 and is involved in telomeric silencing
putative (Lcb2 = LcbB = catalytic domain)
Homolog of Saccharomyces cerevisiae RAD5, a single-stranded DNA-dependent ATPase, involved in postreplication repair; contains RING finger domain
hypothetical protein unknown function, predicted ER membrane localized
Cyclic-AMP phosphodiesterase (PDE) that hydrolyzes the cAMP to the corresponding nucleoside 5' monophosphate (AMP). This protein has three PDEase domains.
microtubule/calcium-binding protein TCTP
required for posttranscriptional gene silencing and RNA interference RNA processing and modification; putative homolog of Neurospora crassa qde-1
Ca2+-modulated nonselective cation channel polycystin
related to intracellular calcium signaling
hard surface induced protein 3-like protein
Related to hard surface induced protein 3 (Chip3)
triose-phosphate isomerase; phosphotriose isomerase; triose phosphoisomerase; triose phosphate mutase; D-glyceraldehyde-3-phosphate ketol-isomerase
matrix processing peptidase of mitochondria
putative STL major facilitator superfamily sugar transporter
Shows sequence similarity to STL proteins. These are sugar transporter proteins. Predicted signal peptide. Predicted membrane localization.
cysteine-rich protein with half-hydrophobin motif
putative HAM-2, hyphal anastomosis-2 protein
[Function] HAM-2 (NCU03726) encodes a putative transmembrane protein of unknown function althought it is involved in conidial anatomosis. Its ortholog in budding yeast (FAR11) is required for pheromone initiated cell cycle arrest during mating.[Domain]N1221-like protein (PF07923)The sequences featured in this family are similar to a hypothetical protein product of ORF N1221 in the CPT1-SPC98 intergenic region of the yeast genome (P53917).
Putative homolog of Saccharomyces cerevisiae RDH54, a DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis
Glycosyl hydrolase family 61 (PF03443) || Putative Endoglucanase-4 precursor (Endoglucanase IV) (Endo-1,4-beta-glucanase IV) (Cellulase IV) (EGIV). Predicted signal peptide.
Putative homolog of Saccharomyces cerevisiae SET2; a with a role in transcriptional elongation, methylates a lysine residue of histone H3