Scheffersomyces stipitis CBS 6054 chromosome 5, complete sequence.
Scheffersomyces stipitis CBS 6054 (Pichia stipitis CBS 6054)
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis
Submitted (05-JUN-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-DEC-2006) US DOE Joint Genome Institute, 2800 Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP000499.\nURL -- http://www.jgi.doe.gov/pichia\nJGI Project ID: 3634480\nSource DNA was provided by Jose Laplaza and Thomas Jeffries\n(twjeffri@wisc.edu)\nStock culture is available from Cletus P Kurtzman\n(kurtsman@ncaur.usda.gov)\nContacts: Thomas Jeffries (twjeffri@wisc.edu)\n Paul Richardson (microbes@cuba.jgi-psf.org)\nAnnotation done by JGI-PGF\nManual curation done by the P. stipitis User Community\nFinishing done by JGI-Stanford Human Genome Center\n(www-shgc.stanford.edu)\nUnresolved repeat 18660-21380\nUnresolved repeat 1370460-1372960\nThe finished chromosome has no gaps. The sequence has less than one\nerror in 100,000 bp.\nThe JGI and collaborators endorse the principles for the\ndistribution and use of large scale sequencing data adopted by the\nlarger genome sequencing community and urge users of this data to\nfollow them. It is our intention to publish the work of this\nproject in a timely fashion and we welcome collaborative\ninteraction on the project and analysis.\n(http://www.genome.gov/page.cfm?pageID=10506376).\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
zinc finger protein possibly regulating maltose complex or other sugar transporters
zinc finger protein possibly regulating maltose complex or other sugar transporters (MAL33); go_component nucleus; go_function transcription factor activity; zinc ion binding; DNA binding; go_process regulation of transcription, DNA-dependent; transcription
Maltose permease some smilarity to Candida albicans MAL31; go_component integral to membrane; go_function transporter activity; go_process transport
alpha-D-glucosidase (maltase) (alpha-amylase) (MAL2) (MALT); go_function alpha-amylase activity; go_process carbohydrate metabolism
Has EST support; similar to Candida albicans HYR1
hyphally regulated cell wall protein similar to Candida albicans HYR1
Hypothetical threonine-rich protein may be involved in floculation
go_function oxidoreductase activity; go_process metabolism
go_function alcohol dehydrogenase activity, zinc-dependent; zinc ion binding
zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type
Probable sucrose utilization protein (SUC1) or maltose fermentation regulatory protein (MAL13)
Fungal specific transcription factor; go_function DNA binding; transcription factor activity
go_process intracellular signaling cascade
diacylglycerol pyrophosphate phosphatase
go_function cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; go_process ubiquitin-dependent protein catabolism
D-arabinitol 2-dehydrogenase [ribulose forming] (ARDH)
D-arabinitol 2-dehydrogenase [ribulose forming] (ARDH) [EC:1.1.1.184] [KO:K00079]; go_function D-arabinitol 2-dehydrogenase activity; go_process metabolism
spermidine exporter, MDR-type pump (TPO3); go_component integral to membrane; go_function transporter activity; go_process transport
Synaptic vesicle transporter SVOP; go_component integral to membrane; go_function transporter activity; go_process transport
N-acetyltransferase HPA3 Histone and other Protein Acetyltransferase; go_function N-acetyltransferase activity
protein involved in nonallelic heterokaryon incompatibility
extremely serine rich protein - mucin-like protein
mucin-like protein containing chitinase features probably part of mannoprotein cell wall possibly involved in adhesion
bHLH DNA-binding protein that promotes hyphal development
go_component membrane; go_process proton transport
protein responsible for ER-associated degradation (ERAD) of numerous ER-resident proteins
HMG-CoA Reductase Degradation responsible for ER-associated degradation (ERAD) of numerous ER-resident proteins
part of small (ribosomal) subunit (SSU) processosome; U3 snoRNP protein
part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); 57 kDa nucleolar protein involved in the pre-rRNA processing steps that lead to formation of 18 S rRNA; interacts with Nop1p
go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation
mitochondrial intermediate peptidase involved in protein import
go_function metalloendopeptidase activity; go_process proteolysis and peptidolysis
go_component membrane; go_process transport
Has EST support; similar to bacterial seryl-tRNA synthases
similar to bacterial seryl-tRNA synthase; go_function tRNA ligase activity; ATP binding; serine-tRNA ligase activity; go_process tRNA aminoacylation for protein translation; seryl-tRNA aminoacylation; go_function tRNA ligase activity; ATP binding; serine-tRNA ligase activity; go_process tRNA aminoacylation for protein translation; seryl-tRNA aminoacylation
multicopper ferro-O2- oxidoreductase involved in high-affinity iron uptake; go_function copper ion binding
go_function catalytic activity; ubiquitin activating enzyme activity; go_process protein modification; ubiquitin cycle
go_component nucleus; small nucleolar ribonucleoprotein complex
go_function nucleic acid binding; nuclease activity; go_process DNA metabolism
mitochondrial ribosomal protein of small subunit
nuclear envelope protein dispensable for mitotic spindle pole body duplication, but required for insertion of nascent spindle pole bodies into the nuclear envelope. ndc1 parental spindle pole bodies form monopolar spindles in mitosis. Required for meiosis II.
monovalent cation:H+ antiporter, CPA1 family (NHX1)
go_component integral to membrane; go_function solute:hydrogen antiporter activity; go_process regulation of pH
member of triose phosphate translocator family
Mitochondrial tricarboxylate/dicarboxylate carrier protein; go_component membrane; go_function binding; go_process transport
Protein transport protein SEC9 plasma membrane t-SNARE
go_component integral to membrane; go_function protein-S-isoprenylcysteine O-methyltransferase activity; go_process C-terminal protein amino acid methylation
go_component cytoskeleton; go_process regulation of actin filament polymerization
Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits
go_function catalytic activity; triacylglycerol lipase activity; go_process lipid metabolism
go_function inositol or phosphatidylinositol phosphatase activity
ATP-dependent RNA helicase DHR2 (DEAH-box RNA helicase DHR2) (Helicase JA2)
go_function nucleic acid binding; helicase activity; ATP binding
Tyrosyl-tRNA synthetase, mitochondrial precursor (Tyrosine--tRNA ligase) (TyrRS); go_function tRNA ligase activity; ATP binding; go_process tRNA aminoacylation for protein translation
Peroxiredoxin HYR1 (Hydrogen peroxide resistance protein 1) (Oxidant receptor peroxidase 1) (Glutathione peroxidase 3) (Phospholipid hydroperoxide glutathione peroxidase 3) (PHGPx3); go_function glutathione peroxidase activity; go_process response to oxidative stress
Serine/threonine kinase similar to casein kinase II and other serine/threonine protein kinases; go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation
mitochondrial ketol-acid reductoisomerase
go_function ketol-acid reductoisomerase activity; go_process branched chain family amino acid biosynthesis
go_component intracellular; ribosome; go_function structural constituent of ribosome; go_process protein biosynthesis
conserved hypothetical protein of low complexity
go_function DNA binding; DNA topoisomerase type I activity; go_process DNA topological change; DNA unwinding
putative beta-glucosidase Septation protein SUN4 precursor (Soluble cell wall protein 3) SIM1 (putative)
go_component nucleus; go_function nucleic acid binding; zinc ion binding
go_component integral to membrane; go_function copper ion transporter activity; go_process copper ion transport
go_component exocyst; go_process vesicle docking during exocytosis; protein transport
Has EST support. upregulated six fold on GA relative to GOL, XOL, XA
phosphoglycerate kinase [EC:2.7.2.3] [KO:K00927]; go_function phosphoglycerate kinase activity; go_process glycolysis
go_function catalytic activity; go_process metabolism
Cytochrome c oxidase assembly protein COX15
Cytochrome oxidase assembly factor COX15 Posttranslational modification, protein turnover, chaperones; go_component membrane; go_process protein complex assembly
A phosphatase required for mitotic exit Cdc14p is in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase it can then act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; go_function protein tyrosine/serine/threonine phosphatase activity; go_process protein amino acid dephosphorylation; go_function protein tyrosine/serine/threonine phosphatase activity; go_process protein amino acid dephosphorylation
cofilin/tropomyosin-type actin-binding protein
go_component nucleus; go_function transcription factor activity; go_process DNA repair; regulation of transcription, DNA-dependent
go_function zinc ion binding; hydrolase activity
A(acid, azole) Q(quinidine) Resistance multidrug resistance transporter
go_function acyltransferase activity; go_process metabolism
Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily TRA1
with sequence similarity to human protein TRRAP which we have isolated as an essential cofactor of c-Myc.; go_function phosphotransferase activity, alcohol group as acceptor
NADH:flavin oxidoreductase (old yellow enzyme); go_function oxidoreductase activity; go_process electron transport
NAPDH dehydrogenase (old yellow enzyme), isoform 2
NAPDH dehydrogenase (old yellow enzyme), isoform 2 (OYE23); go_function oxidoreductase activity; go_process electron transport
NAPDH dehydrogenase (old yellow enzyme) (EPB1)
Has EST support; ADR1-like Zn finger domain at N-terminus all other portion of the protein has changed as compared to Saccharomyces cerevisiae
ADR1-like Zn finger domain at N-terminus all other portion of the protein has changed as compared to Saccharomyces cerevisiae; go_component nucleus; go_function nucleic acid binding; zinc ion binding; go_component nucleus; go_function nucleic acid binding; zinc ion binding
mitochondrial DNA polymerase catalytic subunit
MItochondrial DNA Polymerase catalytic subunit: DNA polymerase gamma (Mitochondrial DNA polymerase catalytic subunit) (DPOG); go_function DNA binding; DNA-directed DNA polymerase activity; go_process DNA replication
Eukaryotic translation initiation factor 5A (eIF-5A) (eIF-4D)
Has EST support. Present in aerobic cells; largely absent under oxygen limitation
Eukaryotic translation initiation factor 5A-2 (eIF-5A 2) (eIF-4D) (Hypusine containing protein HP2); go_function translation initiation factor activity
RNA polymerase II holoenzyme/mediator subunit
Putative mitochondrial protein of unknown function
pyridoxine-pyridoxal-pyridoxamine kinase
protein involved in vesicle formation at the endoplasmic reticulum
go_component nucleus; go_function DNA binding
Probable formate transporter 1 (Formate channel 1)
go_component membrane; go_function transporter activity; go_process transport
ATP-dependent RNA helicase DBP9 (DEAD-box protein 9)
putative multidrug resistance protein (TPO1); go_component integral to membrane; go_function transporter activity; go_process transport
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
protein involved in vacuolar protein sorting
involved in vacuolar protein sorting (SNF7); go_function molecular function unknown; go_function molecular function unknown
lactose regulatory protein LAC9 and GAL4-like protein
positive regulator of GAL genes; go_component nucleus; go_function transcription factor activity; zinc ion binding; DNA binding; go_process regulation of transcription, DNA-dependent; transcription; go_component nucleus; go_function transcription factor activity; zinc ion binding; DNA binding; go_process regulation of transcription, DNA-dependent; transcription
go_function malic enzyme activity; go_process malate metabolism
Adenylate kinase (ATP-AMP transphosphorylase)
go_function ATP binding; adenylate kinase activity
pre-mRNA cleavage and polyadenylation factor I subunit
lacks the HMG1-like mitochondrial HM protein putative mitochondrial carrier protein
lacks the HMG1-like mitochondrial HM protein putative mitochondrial carrier protein; go_component membrane; go_function binding; go_process transport; go_component membrane; go_function binding; go_process transport
go_component intracellular; ribosome; go_function RNA binding; structural constituent of ribosome; go_process protein biosynthesis
mitochondrial 37S ribosomal protein YmS18
serine/threonine/tyrosine protein kinase involved in chromosome segregation
Glycogen synthase kinase-3 serine/threonine/tyrosine protein kinase involved in chromosome segregation; go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation
WD domain protein likely involved in chromatin remodeling not highly conserved - similar to mammalian protein
mitochondrial protein with homology to MRS2 (LPE10); go_function metal ion transporter activity; go_component membrane; go_process metal ion transport; go_function metal ion transporter activity; go_component membrane; go_process metal ion transport
minichromosome maintenance syntenic homolog of Saccharomyces cerevisiae YDR318W (MCM21)
DNA-dependent RNA polymerase I subunit A43
go_component nucleus; go_function DNA binding; DNA-directed RNA polymerase activity; go_process transcription
essential for splicing of group II introns
essential for splicing of group II introns; go_function metal ion transporter activity; go_component membrane; go_process metal ion transport; go_function metal ion transporter activity; go_component membrane; go_process metal ion transport
vacuolar ATP synthase subunit E (V-ATPase E subunit) (Vacuolar proton pump E subunit)
go_function hydrogen-transporting ATP synthase activity, rotational mechanism; hydrogen-transporting ATPase activity, rotational mechanism; go_component proton-transporting two-sector ATPase complex; go_process ATP synthesis coupled proton transport
go_component membrane; go_function binding; go_process transport
5-aminolevulinate synthase, mitochondrial precursor (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
go_function transaminase activity; 5-aminolevulinate synthase activity; go_process biosynthesis; heme biosynthesis
proton-dependent oligopeptide transporter, POT family
go_component membrane; go_function transporter activity; go_process oligopeptide transport
conserved hypothetical protein Predicted RNA-binding protein
similar to Serologically defined colon cancer antigen 1 (Antigen NY-CO-1) [homo sapiens]
putative histone deacetylase-like protein
similar to Hst1p and Sir2p putative histone deacetylases
NAD-dependent deacetylase HST2 (Homologous to SIR2 protein 2); go_component chromatin silencing complex; go_function DNA binding; go_process chromatin silencing; regulation of transcription, DNA-dependent; go_component chromatin silencing complex; go_function DNA binding; go_process chromatin silencing; regulation of transcription, DNA-dependent
henylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS)
henylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS) (SYFB)
involved in transport and fusion of post-Golgi secretory vesicles to the plasma membrane
involved in transport and fusion of post-Golgi secretory vesicles to the plasma membrane; go_function GTP binding; go_process small GTPase mediated signal transduction; go_function GTP binding; go_process small GTPase mediated signal transduction
Similar to NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 NUFM [homo sapiens]; go_function oxidoreductase activity, acting on NADH or NADPH; go_component mitochondrial inner membrane; go_process electron transport
WW domain containing protein interacting with Metacaspase (MCA1)
WW domain containing protein interacting with Metacaspase (MCA1) involved in response to dessication
Required for nuclear and mitochondrial transmission to daughter buds; go_process intracellular signaling cascade
U4/U6 snRNA-associated splicing factor PRP24 (U4/U6 snRNP protein)
go_function tRNA ligase activity; ATP binding; go_process tRNA aminoacylation for protein translation
F box protein, for ubiquitin- dependent degradation
homologue of mammalian SRP19; go_component signal recognition particle (sensu Eukaryota); go_function RNA binding; 7S RNA binding; go_process protein targeting; go_component signal recognition particle (sensu Eukaryota); go_function RNA binding; 7S RNA binding; go_process protein targeting
putative Ca2+ ATPase similar to mammalian Sodium/potassium-transporting ATPase alpha chain (Sodium pump) (Na+/K+ ATPase); go_component membrane; go_function ATP binding; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; catalytic activity; go_process cation transport; metabolism
methionine-synthesizing 5- methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
go_function 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; go_process methionine biosynthesis
isolated as a suppressor of the lethality caused by overexpression of the phosphoprotein phosphatase 1 catalytic subuniut encoded by GLC7
Third step in pyrimidine biosynthesis pathway
Third step in pyrimidine biosynthesis pathway; go_function hydrolase activity; go_function hydrolase activity
go_component integral to membrane; go_function transporter activity; go_process transport
Diadenosine and Diphosphoinositol Polyphosphate Phosphohydrolase
mitochondrial 37S ribosomal protein YMR31
go_component proteasome core complex (sensu Eukaryota); go_function endopeptidase activity; go_process ubiquitin-dependent protein catabolism
3',5'-cyclic-nucleotide phosphodiesterase (PDEase) (3':5'-CNP)
3',5'-cyclic-nucleotide phosphodiesterase (PDE1) (PDEase) (3':5'-CNP); go_function cAMP-specific phosphodiesterase activity; go_process cAMP catabolism
go_component vacuole; go_function aminopeptidase I activity; go_process proteolysis and peptidolysis
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase
Beta-hexosaminidase precursor (N-acetyl-beta-glucosaminidase) (Beta-GlcNAcase) (Beta-N-acetylhexosaminidase) Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; go_function beta-N-acetylhexosaminidase activity; go_process carbohydrate metabolism
go_function lyase activity; go_process amino acid metabolism
Gluconate transport-inducing protein similar to camp-independent regulatory protein PAC2
Acetyl-CoA hydrolase (Acetyl-CoA deacylase) (Acetyl-CoA acylase)
go_function catalytic activity; go_process acetyl-CoA metabolism
go_function ATP binding; molecular function unknown
Required for an essential posttranslational stage in assembly of cytochrome oxidase; go_component membrane
go_function GTP binding; go_process protein biosynthesis
eIF2 is a heterotrimeric GTP-binding protein SUI2 encodes the alpha subunit SUI3 encodes the beta subunit
go_component nucleus; go_function transcription factor activity; zinc ion binding; DNA binding; go_process regulation of transcription, DNA-dependent; transcription
Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor
Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (UQCR2); go_function metalloendopeptidase activity; go_process proteolysis and peptidolysis
subunit common to RNA polymerases I, II, and III
go_function DNA binding; DNA-directed RNA polymerase activity; go_process transcription, DNA-dependent
likely the regulatory light chain for the type II myosin, Myo1p. Mlc2p binds to an IQ motif of Myo1p. Mlc2p localization to the bud neck depends on Myo1p
centractin- actin-related protein of the dynactin complex
go_component actin cytoskeleton; go_function structural constituent of cytoskeleton
uracil phosphoribosyltransferase Regulation of the pyrimidine salvage pathway (UPRTase); go_process nucleoside metabolism
family 17 glucosidase SCW11 precursor (Soluble cell wall protein 11)
go_component membrane; go_function phosphatidate cytidylyltransferase activity; go_process phospholipid biosynthesis
go_function translation initiation factor activity; go_process translational initiation
Cyclin-dependent kinases regulatory subunit (Cell division control protein CKS1)
go_function cyclin-dependent protein kinase activity; go_process cell cycle
1-phosphatidylinositol 3-kinase.; go_function phosphotransferase activity, alcohol group as acceptor
go_function damaged DNA binding; ATP binding; go_process mismatch repair
p21-activated serine/threonine protein kinase Signal transduction mechanisms; go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation
Arylacetamide deacetylase; go_function catalytic activity
beta glucosidase family 3; go_function hydrolase activity, hydrolyzing O-glycosyl compounds; go_process carbohydrate metabolism
Geranylgeranyl pyrophosphate synthetase (GGPP synthetase) (GGPPSase) (Geranylgeranyl diphosphate synthase) [Includes: Dimethylallyltranstransferase Geranyltranstransferase Farnesyltranstransferase ]; go_process isoprenoid biosynthesis
diphthamide biosynthesis methyltransferase
go_function methyltransferase activity; go_process metabolism
zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type
class II aldolase and adducin N terminal domain
member of the syntaxin family of t-snares
Set1C component SDC1 (Suppressor of CDC25 protein 1)
some similarity to COMPASS component SDC1; possibly involved in chromatin remodeling member of Set1p complex
inosine triphosphate pyrophosphatase, putative / HAM1 family protein
Thiamine pyrophosphokinase (TPK) (Thiamine kinase)
go_function thiamin diphosphokinase activity; ATP binding; go_process thiamin diphosphate biosynthesis
go_component transcription factor TFIID complex; go_process transcription initiation
go_function protein transporter activity; go_component nucleus; nuclear pore; cytoplasm; go_process protein-nucleus import, docking
copper-transporting ATPase (Cu(2+)-ATPase)
copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; go_component membrane; go_function ATP binding; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; metal ion binding; catalytic activity; go_process metal ion transport; metabolism
go_function disulfide oxidoreductase activity; go_process electron transport
protein possibly processed from cytochrome c import factor
CYC2_YEAST Cytochrome c mitochondrial import factor CYC2
Histone transcription regulator HIRA, WD repeat superfamily
go_function protein kinase CK2 regulator activity; go_component protein kinase CK2 complex
mitochondrial tryptophanyl-tRNA synthetase
putative phosphate epimerase similar to Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
Vacuolar protein sorting protein 46 (Charged multivesicular body protein 1) (DOA4-independent degradation protein 2) (Fifty two inhibitor 1)
nucleoside diphosphate kinase catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis; go_function nucleoside-diphosphate kinase activity; ATP binding; go_process GTP biosynthesis; UTP biosynthesis; CTP biosynthesis
transcription factor, probable member of histone acetyltransferase SAGA complex
Trimethyllysine dioxygenase (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML-alpha-ketoglutarate dioxygenase) (TML hydroxylase) (TML dioxygenase) (TMLD)
Trimethyllysine dioxygenase (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML-alpha-ketoglutarate dioxygenase) (TML hydroxylase) (TMLH) (TML dioxygenase) (TMLD); go_function oxidoreductase activity
NAD(P)H-dependent D-xylose reductase (XR)
transcription factor involved in glucose repression
transcription factor involved in glucose repression similar to DNA-binding protein creA (Carbon catabolite repressor); go_component nucleus; go_function nucleic acid binding; zinc ion binding
putative transcriptional activator with fungal binuclear cluster domain; go_component nucleus; go_function transcription factor activity; zinc ion binding; DNA binding; go_process regulation of transcription, DNA-dependent; transcription
sorbitol dehydrogenase (ADH) [BACTERIAL]; go_function alcohol dehydrogenase activity, zinc-dependent; zinc ion binding
go_function DNA binding; go_process regulation of transcription, DNA-dependent
go_function proline dehydrogenase activity; go_process glutamate biosynthesis; proline catabolism
go_function GTP binding; go_process cell cycle
UDP-N-acetylglucosamine pyrophosphorylase
go_function nucleotidyltransferase activity; go_process metabolism
hypothetical protoplast-secreted beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain (ECM33)
hypothetical protoplast-secreted beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain similar to Extracellular matrix protein 33 precursor
mitochondrial succinate-fumarate transporter
go_component intracellular; go_function ubiquitin thiolesterase activity; go_process ubiquitin-dependent protein catabolism
go_function electron transporter activity; go_process electron transport
go_function glycerophosphodiester phosphodiesterase activity; go_process glycerol metabolism
mitochondrial 37S ribosomal protein RSM26
go_function superoxide dismutase activity; metal ion binding; go_process superoxide metabolism
go_function catalytic activity; CTP synthase activity; go_process pyrimidine nucleotide biosynthesis
protein required for glucose repression and for glucose and cation transport
go_function translation initiation factor activity; go_process translational initiation; regulation of translational initiation
component of a pre-mRNA polyadenylation factor
Integrin alpha chain-like protein (Alpha-INT1)
go_function metallopeptidase activity; go_process proteolysis and peptidolysis
Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins
Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins (CDC332); go_component cytoplasm; go_function RNA binding; translation initiation factor activity; go_process translational initiation
go_function carboxypeptidase A activity; go_process proteolysis and peptidolysis
go_function hydrolase activity, acting on ester bonds; go_component cytoplasm; go_process D-amino acid catabolism
go_component membrane; go_function amino acid-polyamine transporter activity; go_process amino acid transport
go_component nucleus; go_process regulation of transcription, DNA-dependent
4-aminobutyrate aminotransferase (GABA transaminase)
go_function carboxylic ester hydrolase activity; go_process lipid metabolism
uridine nucleosidase (uridine ribohydrolase)
go_component clathrin vesicle coat; go_process intracellular protein transport
go_function oxidoreductase activity; go_process amino acid metabolism
ER protein that transfers Glc-Nac-P from UDP-GlcNac to Dol-P; go_component membrane; go_function catalytic activity; go_process lipid metabolism
mitochondrial thiamine pyrophosphate transporter
mitochondrial thiamine pyrophosphate transporter Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source; go_component membrane; go_function binding; go_process transport
S. cerevisiae homolog is necessary for sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa; go_function catalytic activity; go_process metabolism
3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase); go_function oxidoreductase activity; go_process metabolism
putative short chain dehydrogenase Glucose/ribitol dehydrogenase; go_function oxidoreductase activity; go_process metabolism
required for vegetative and meiotic growth
Exosome complex exonuclease RRP46 (Ribosomal RNA processing protein 46)
go_function 3'-5'-exoribonuclease activity; RNA binding; go_process RNA processing
Has EST support; required for late nuclear division. Cdc15 promotes the exit from mitosis by directly switching on the kinase activity of Dbf2
required for late nuclear division. Cdc15 promotes the exit from mitosis by directly switching on the kinase activity of Dbf2; go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation; go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation
Has EST support; member of the TC 9.B.33 YaaH family of putative transporters
member of the TC 9.B.33 YaaH family of putative transporters; go_component membrane; go_function molecular function unknown; go_component membrane; go_function molecular function unknown
GDP/GTP exchange factor Gdp/GTP exchange factor required for growth at low temperatures; go_function guanyl-nucleotide exchange factor activity; go_process intracellular signaling cascade
transcriptional regulator of the forkhead/HNF3 family
go_component nucleus; go_function transcription factor activity; go_process regulation of transcription, DNA-dependent
Has EST support; a member of a conserved family of actin monomer sequestering proteins. TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin (COF1)
a member of a conserved family of actin monomer sequestering proteins. TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin (COF1); go_component intracellular; go_function actin binding; go_component intracellular; go_function actin binding
TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin
go_component peroxisomal membrane; integral to membrane
go_function protein phosphatase type 2A regulator activity; go_component protein phosphatase type 2A complex; go_process signal transduction
translocates LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
translocates LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; go_component integral to membrane; go_process response to xenobiotic stimulus; go_component integral to membrane; go_process response to xenobiotic stimulus
putative transporter or flippase transmembrane protein
go_component integral to membrane; go_process response to xenobiotic stimulus
4-hydroxyphenylpyruvate dioxygenase (4HPPD) (HPD) (HPPDase)
basic helix-loop-helix transcription factor
basic helix-loop-helix transcription factor Enhanced filamentous growth protein; go_function DNA binding; transcription factor activity; go_process regulation of transcription, DNA-dependent
go_function GTP binding; go_process small GTPase mediated signal transduction
go_function translation release factor activity; go_process translational termination
DNA replication licensing factor, MCM5 component
DNA replication licensing factor, MCM5 component part of ARS replication initiation complex (CDC46); go_function DNA binding; ATP binding; DNA-dependent ATPase activity; go_process DNA replication initiation
go_function transaminase activity; go_process metabolism
go_function GTP binding; translation elongation factor activity; go_process protein biosynthesis; translational elongation
go_function lyase activity; threonine ammonia-lyase activity; go_process amino acid metabolism; isoleucine biosynthesis
Sulfite reductase [NADPH] beta subunit (Extracellular matrix protein 17)
exopolyphosphatase (ExopolyPase) (Metaphosphatase)
go_function pyrophosphatase activity; go_component cytoplasm
go_component membrane; go_function mannosyltransferase activity; go_process O-linked glycosylation
go_function palmitoyl-(protein) hydrolase activity; go_component lysosome; go_process protein modification
ATP synthase F0 sector subunit 4 analogous to the bovine b subunit; go_function hydrogen-transporting ATP synthase activity, rotational mechanism; hydrogen-transporting ATPase activity, rotational mechanism; go_component proton-transporting two-sector ATPase complex; go_process ATP synthesis coupled proton transport
Predicted glutamine synthetase glutamine amidotransferase
glutathione S- transferase, nitrogen catabolite repression regulator
go_component extracellular region; go_process cell wall biosynthesis
mitochondrial inner membrane import translocase subunit
Mitochondrial import inner membrane translocase subunit TIM17 (Mitochondrial protein import protein 2) (Mitochondrial inner membrane protein MIM17); go_function protein translocase activity; go_component mitochondrial inner membrane presequence translocase complex; go_process protein transport
serine-threonine protein kinase, PKA suppressor
Chromodomain-helicase DNA-binding protein
family 17 glucosidase SCW4 precursor (Soluble cell wall protein 4)
go_function nucleotidyltransferase activity; go_process biosynthesis
go_function RNA binding; go_process protein biosynthesis
go_component mitochondrial electron transport chain; go_function heme binding; electron transporter activity; go_process electron transport
go_function oxidoreductase activity; go_process electron transport
go_component membrane; integral to membrane; go_function ATP binding; go_process transport
6-phosphogluconolactonase [EC:1.1.1.49] [KO:K00036]
catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate
go_function hydro-lyase activity; go_process tRNA processing
go_component microtubule associated complex; go_function motor activity; ATP binding
nucleolar shuttling protein with an RNA recognition motif
SPT3 Dosage dependent suppressor of Ty-induced promoter mutations-like protein
similar to SPT3 Dosage dependent suppressor of Ty-induced promoter mutations. Homolog of Mga2. Spt23p and Mga2p differentially activate and regulate OLE1 transcription
Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) (UROIIIS)
go_function uroporphyrinogen-III synthase activity; go_process porphyrin biosynthesis; heme biosynthesis
go_function hydroxymethylbilane synthase activity; go_process porphyrin biosynthesis
go_function methylenetetrahydrofolate reductase (NADPH) activity; go_process methionine metabolism
go_function peptidase activity; go_process proteolysis and peptidolysis
uroporphyrinogen decarboxylase fifth enzyme in the heme biosynthetic pathway; go_function uroporphyrinogen decarboxylase activity; go_process porphyrin biosynthesis
required for mitotic diploid-specific recombination and repair
required for mitotic diploid-specific recombination and repair; go_function DNA binding; ATP binding; nucleic acid binding; helicase activity; type III site-specific deoxyribonuclease activity; go_process DNA restriction-modification system; go_function DNA binding; ATP binding; nucleic acid binding; helicase activity; type III site-specific deoxyribonuclease activity; go_process DNA restriction-modification system
DNA-directed RNA polymerases III 12.5 kDa polypeptide; go_function DNA binding; transcription factor activity; DNA-directed RNA polymerase activity; go_process RNA elongation; regulation of transcription, DNA-dependent; transcription
Origin recognition complex subunit 2 (Origin recognition complex protein 71 kDa subunit)
go_component origin recognition complex; nucleus; go_process DNA replication
Ark-family serine/threonine protein kinase
Ark-family serine/threonine protein kinase regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; go_function protein kinase activity; ATP binding; go_process protein amino acid phosphorylation
CTD kinase gamma subunit (CTD kinase 32 kDa subunit) (CTDK-I gamma subunit)
alpha,alpha-trehalose-phosphate synthase, regulatory subunit
go_function alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; go_process trehalose biosynthesis
go_function glutamate-tRNA ligase activity; ATP binding; go_process glutamyl-tRNA aminoacylation
regulatory subunit for phosphoprotein phosphatase type 1 (PP-1)
regulatory subunit for phosphoprotein phosphatase type 1 (PP-1) (PIG)
go_function DNA binding; DNA-directed RNA polymerase activity; go_process transcription
Has EST support; may be required for nuclear division
Glutamyl-tRNA synthetase, cytoplasmic (Glutamate--tRNA ligase) (GluRS) (P85); go_function glutamate-tRNA ligase activity; ATP binding; go_process glutamyl-tRNA aminoacylation
Protein involved in regulation of cell size putative RNA binding protein
Protein involved in regulation of cell size whi (Wee) mutants give small cell size putative RNA binding protein
Transport protein particle 33 kDa subunit (TRAPP 33 kDa subunit)
Arginine biosynthesis bifunctional protein ARG7, mitochondrial precursor (Extracellular matrix protein 40) [Includes: Glutamate N-acetyltransferase (Ornithine acetyltransferase) (Ornithine transacetylase) (OATase) Amino-acid acetyltransferase (N-acetylglutamate synthase) (AGS)] [Contains: Arginine biosynthesis bifunctional protein ARG7 alpha chain Arginine biosynthesis bifunctional protein ARG7 beta chain]; go_function glutamate N-acetyltransferase activity; go_process arginine biosynthesis
Curved DNA-binding protein (42 kDa protein)
go_function metalloexopeptidase activity; go_process proteolysis and peptidolysis
protein required for amino acid permease transport from the Golgi to the cell surface
regulator of cell wall mannosyl phosphorylation
go_component exocyst; go_process exocytosis
protein required for normal CLN1 and CLN2 G1 cyclin expression
TPR-containing nuclear phosphoprotein that regulates K(+) uptake required for normal CLN1 and CLN2 G1 cyclin expression
guanine deaminase (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH)
transcription factor of the MADS box family
Pheromone receptor transcription factor (GRM/PRTF protein) Involved in cell-type-specific transcription and pheromone response; go_component nucleus; go_function transcription factor activity; go_process regulation of transcription, DNA-dependent
Releases glucose-1-phosphate from glycogen
go_function phosphorylase activity; go_process carbohydrate metabolism
carboxypeptidase B-like processing protease
go_function serine carboxypeptidase activity; go_process proteolysis and peptidolysis
mitochondrial 54S ribosomal protein YmL6
Homeodomain protein that binds leu-tRNA gene. acts as a repressor at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle.; go_component nucleus; go_function DNA binding; transcription factor activity; go_process regulation of transcription, DNA-dependent
Phosphate metabolism transcription is regulated by PHO system
go_component intracellular; ribosome; go_function structural constituent of ribosome; go_process translational elongation; protein biosynthesis
mitochondrial 37S ribosomal protein MRPS16
Has EST support; Required for normal pre-rRNA Processing. Member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift
Required for normal pre-rRNA Processing. Member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift
conserved membrane protein with BTB/POZ domain
Flavonol reductase/cinnamoyl-CoA reductase
go_function oxidoreductase activity; go_process electron transport; aromatic compound metabolism
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2
probable inositol 2-dehydrogenase; go_function oxidoreductase activity; go_process electron transport; metabolism
mitochondrial morphology and distribution
ATP-dependent RNA helicase DBP7 (DEAD-box protein 7)
translation initiation factor eIF-2B alpha subunit (GCN3)
go_component eukaryotic translation initiation factor 2B complex; go_function translation initiation factor activity; GTP binding; go_process translational initiation
Has EST support; interacts with the translational machinery
interacts with the translational machinery
conerved hypothetical protein with WD repeats
Folylpolyglutamate synthase (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase); go_function ATP binding; ligase activity; go_process biosynthesis
DNA replication complex GINS protein PSF1
eIF2-alpha Serine/threonine-protein kinase
go_component nucleus; go_function hydrolase activity; endonuclease activity; manganese ion binding; go_process double-strand break repair
double-strand break repair protein MRE11
conserved hypothetical transmembrane protein
20th gene involved in cytochrome oxidase activity
go_function protein tyrosine/serine/threonine phosphatase activity; go_process protein amino acid dephosphorylation
Replication factor C, subunit RFC4 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA; go_function ATP binding
small nucleolar RNA-associated protein 18 (U3 snoRNA-associated protein 18)
go_component nucleus; cytoplasm; go_function tRNA binding; go_process tRNA-nucleus export
Cysteine synthase 2 (O-acetylserine sulfhydrylase 2) (O-acetylserine (Thiol)-lyase 2) (CSase 2); go_function lyase activity; go_process amino acid metabolism
Similar to ScNRG1, which is involved in regulation of glucose repression in that organism; go_component nucleus; go_function nucleic acid binding; zinc ion binding
go_component integral to membrane; GPI-anchor transamidase complex
Threonyl-tRNA synthetase, cytoplasmic (Threonine--tRNA ligase) (ThrRS); go_function tRNA ligase activity; ATP binding; go_process tRNA aminoacylation for protein translation; protein biosynthesis
mitochondrial 54S ribosomal protein YmL38/YmL34
Importin alpha subunit (Karyopherin alpha subunit) (Serine-rich RNA polymerase I suppressor protein)
Importin alpha subunit (Karyopherin alpha subunit) (Serine-rich RNA polymerase I suppressor protein) (Cell untimely torn protein 15); go_function protein transporter activity; go_process protein-nucleus import; intracellular protein transport
agmatine ureohydrolase (agmatinase) (SPEB2); go_function catalytic activity
go_component nucleus; go_function transcription factor activity; zinc ion binding; go_process regulation of transcription, DNA-dependent