Kluyveromyces lactis strain NRRL Y-1140 chromosome C complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Submitted (25-SEP-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (09-SEP-2008) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CR382123.\nThis is an updated version of the complete genome sequence. The\nKluyveromyces lactis sequence is made of 6 chromosomes (A to F).\nThe sequence was annotated by the Genolevures Consortium. For more\ninformation go to\nhttp://cbi.labri.fr/Genolevures.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport
similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C
similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH
uniprot|Q08398 Kluyveromyces lactis HMLAPLHA1 Mating- type protein ALPHA1
uniprot|Q9HDS5 Kluyveromyces lactis HMLALPHA2 Mating- type protein ALPHA2
uniprot|Q9HDS6 Kluyveromyces lactis HMLALPHA3 Mating- type protein ALPHA3
similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase
weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 vacuole inheritance
weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein found at replication forks required for DNA replication also required for Rad53p activation during DNA replication stress where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p protein involved in replication checkpoint
90S preribosome/SSU processome component KRR1
highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A
similar to uniprot|P25375 Saccharomyces cerevisiae YCL057W PRD1 Zinc metalloendopeptidase found in the cytoplasm and intermembrane space of mitochondria
similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W
similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52 U2921 suppressor of PAB1 mutants
similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I required for the autocatalytic post-translational processing of the protease B precursor Prb1p localizes to ER in lumenal orientation homolog of mammalian PIG-X
some similarities with uniprot|P25579 Saccharomyces cerevisiae YCL051W LRE1 Protein involved in control of cell wall structure and stress response inhibits Cbk1p protein kinase activity overproduction confers resistance to cell-wall degrading enzymes
highly similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C
similar to uniprot|P22108 Saccharomyces cerevisiae YDR530c APA2 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II
similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase EC 2.7.1.33) catalyzes the first committed step in the universal biosynthetic pathway leading to CoA.
weakly similar to uniprot|Q04431 Saccharomyces cerevisiae YDR532C KRE28
similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W
similar to uniprot|P56508 Saccharomyces cerevisiae YDR525W-A
similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 dispensable for mitosis involved in middle/late stage of meiosis required for spore wall formation serine/threonine kinase homologous to Ste20p expressed in middle/late meiosis
similar to uniprot|P25380 Saccharomyces cerevisiae YCL048W SPS22 Protein of unknown function redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C Hypothetical ORF
similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking
similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C
similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C
similar to uniprot|P17967 Saccharomyces cerevisiae YCL043C PDI and similar to uniprot|P32474 Saccharomyces cerevisiae YDR518W EUG1 Protein disulfide isomerases
similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Golgi localized protein component of the spindle assembly checkpoint homolog of human GRASP65 which functions in postmitotic reassembly of Golgi stacks
similar to uniprot|P17709 Saccharomyces cerevisiae YCL040W GLK1 Glucokinase catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism one of three glucose phosphorylating enzymes expression regulated by non-fermentable carbon sources
similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W
similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole
weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes may function in the cytoplasm to modulate mRNA translation may be involved in organization of actin filaments RNA binding protein with La motif
some similarities with uniprot|Q04408 Saccharomyces cerevisiae YDR514C Hypothetical ORF
weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes and weakly similar to uniprot|Q12034 Saccharomyces cerevisiae YDR515W SLF1 RNA binding protein that associates with polysomes
similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C Hypothetical ORF
some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C
similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response invasive/filamentous growth and osmotolerance acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 involved in rRNA processing
some similarities with uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space required for acetate utilization and gluconeogenesis has orthologs in higher eukaryotes
highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C
similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein component of the interface between microtubules and kinetochore involved in sister chromatid separation essential in polyploid cells but not in haploid or diploid cells ortholog of mammalian CLIP-170
some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins
uniprot|Q8NJT3 Kluyveromyces lactis Fus1 protein (Similarity).
highly similar to uniprot|Q8NIM8 Saccharomyces cerevisiae YCL026C- B Hypothetical ORF and similar to YCL026c-A
similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W
similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C
weakly similar to uniprot|P41816 Saccharomyces cerevisiae YPL171C OYE3 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN)
similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Hypothetical ORF
weakly similar to Saccharomyces cerevisiae YLR177W Hypothetical ORF and to YDR505C uniprot|P50896 Saccharomyces cerevisiae YDR505C PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Carboxypeptidase Y inhibitor (putative) lipid binding protein supressor of a cdc25 mutation
similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase catalyzes Mg(2)-independent dephosphorylation of phosphatidic acid (PA) lysophosphatidic acid and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA
highly similar to uniprot|P10659 Saccharomyces cerevisiae YLR180W and to uniprot|P19358 Saccharomyces cerevisiae YDR502C SAM1 S-adenosylmethionine synthetase catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p)
similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Protein involved in endosomal protein sorting binds to Vps20 and Vps4 and may regulate Vps4function has coiled- coil domains mutants show class E vacuolar-protein sorting defects
uniprot|P40418 Kluyveromyces lactis Regulatory protein SWI6 (Cell-cycle box factor, chain SWI6) (Trans-acting activator of HO endonuclease gene) (MBF subunit P90)
similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W PLM2 Plasmid Maintenance and to uniprot|Q06266 YLR183C Saccharomyces cerevisiae TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
highly similar to uniprot|P49166 Saccharomyces cerevisiae YLR185W RPL37A protein and to uniprot|P51402 Saccharomyces cerevisiae YDR500C RPL37B protein, components of the large (60S) ribosomal subunit
weakly similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways interacts physically with Mec1p putative homolog of S. pombe Rad26 and human ATRIP
highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production associated with spindle/microtubules nuclear localization depends on physical interaction with Nop14p may bind snoRNAs
similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating predicted to have 5 transmembrane segments and a coiled coil domain localizes to the shmoo tip regulated by Ste12p
similar to Saccharomyces cerevisiae YLR187W SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate and to YNL278W uniprot|P53836 Saccharomyces cerevisiae YNL278W CAF120 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress
similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase conserved enzyme involved in synthesis of sterol glucoside membrane lipids involved in autophagy
similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Inositol phosphosphingolipid phospholipase C hydrolyzes inositolphosphosphingolipids activated by phosphatidylserine cardiolipin and phosphatidylglycerol mediates Na and Li halotolerance contains a P loop-like domain
similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Vacuolar membrane protein that seems to be involved in Mn2 homeostasis mutant is dependent on activation of the unfolded protein response pathway for viability
similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W
some similarities with uniprot|P25361 Saccharomyces cerevisiae YCR043C Hypothetical ORF
similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C Putative hydroxyisocaproate dehydrogenase
similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa) involved in RNA polymerase II transcription initiation
similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W Hypothetical ORF
similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Protein that interacts with topoisomerase I
similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p located on cytoplasmic vesicles essential for post-Golgi vesicle transport
similar to uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNR1
similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance
similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease one of three amino acid permeases (Alp1p Can1p Lyp1p) responsible for uptake of cationic amino acids
similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase catalyzes first step in the biosynthesis of phosphatidylinositol-4 5-biphosphate may control cytokineses through the actin cytoskeleton
similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W Essential protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p
similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Putative translation initiation factor as suggested by computational analysis of large-scale protein-protein interaction data
similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C
highly similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation involved in transporting proteins from the ER to the cytosol
similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Hypothetical ORF
similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP) downregulates Plb1p-mediated turnover of phosphatidylcholine found in the cytosol and microsomes homologous to Pdr16p deletion affects phospholipid composition
weakly similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C
similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C
similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase epsilon one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity also involved in DNA synthesis during DNA repair
similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
some similarities with uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Nuclear protein that physically interacts with Irr1p a component of the cohesin complex may link together proteins involved in chromosome segregation mRNA splicing and DNA replication
weakly similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Protein required for cell viability
highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
weakly similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Endoplasmic reticulum (ER)-localized peripheral membrane protein required for Golgi-to-ER retrograde traffic component of the ER target site that interacts with coatomer the major component of the COPI vesicle protein coat
similar to uniprot|P38717 Saccharomyces cerevisiae YNL257C SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p C-terminal region has a putative leucine zipper motif potential Cdc28p substrate and to uniprot|P38851 Saccharomyces cerevisiae YHR155W YSP1 Hypothetical ORF
similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triglyceride Lipase
similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesis located on the matrix side of the mitochondrial inner membrane
similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase activities
highly similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C
some similarities with uniprot|P53850 Saccharomyces cerevisiae YNL254C Hypothetical ORF
some similarities with uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 transcription export complex component
mitochondrial 54S ribosomal protein YmL17/YmL30
similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p) required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex with Mre11p and Xrs2p involved in processing double-strand DNA breaks in vegetative cells initiation of meiotic DSBs telomere maintenance and nonhomologous end joining
similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Mitochondrial protein of unknown function and similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF
similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49
similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein required along with Dph1p Dph2p Kti11p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) contains a DnaJ-like domain
similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Hypothetical ORF
similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Protein required for cell viability
similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75
weakly similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C
highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 translation initiation factor eIF1
uniprot|Q707Z3 Kluyveromyces lactis KLLA0C03113g Sla2 protein
highly similar to uniprot|Q9HG12 Kluyveromyces lactis KLLA0B14553g HMRA1 Mating-type protein A1
highly similar to uniprot|Q9HG13 Kluyveromyces lactis KLLA0B14575g HMRA2 Mating-type protein A2
weakly similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C Hypothetical ORF
similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C and some similarities with YIL130W uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins
similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 ReCYcling 1
similar to uniprot|P32524 Saccharomyces cerevisiae YJL203W PRP21 Subunit of the SF3a splicing factor complex required for spliceosome assembly
similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p
some similarities with uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns
highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C Hypothetical ORF
similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C PHO87 Low-affinity inorganic phosphate (Pi) transporter involved in activation of PHO pathway expression is independent of Pi concentration and Pho4p activity contains 12 membrane-spanning segments and to uniprot|P39535 Saccharomyces cerevisiae YJL198W PHO90
similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase
similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Ribosomal RNA Processing
similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W FEN1 Fatty acid elongase involved in sphingolipid biosynthesis acts on fatty acids of up to 24 carbons in length mutations have regulatory effects on 1 3-beta-glucan synthase vacuolar ATPase and the secretory pathway
some similarities with uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1
similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association homologous to S. pombe Cdc18p
similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative)
similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C
some similarities with uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting
similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription
similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W
highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W
similar to uniprot|Q12010 YOL092W Saccharomyces cerevisiae Hypothetical ORF
weakly similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
weakly similar to uniprot|Q7LGP7 Saccharomyces cerevisiae YOL063C HUS1
similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function substrates include SPB proteins Spc42p Spc110p and Spc98p mitotic exit network protein Mob1p and checkpoint protein Mad1p
highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity
some similarities with uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Hypothetical ORF
similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Clathrin associated protein medium subunit
similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes
some similarities with uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p
similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C
highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W GPD1 NAD-dependent glycerol-3-phosphate dehydrogenase key enzyme of glycerol synthesis essential for growth under osmotic stress expression regulated by high-osmolarity glycerol response pathway homolog of Gpd2p
highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway potential Cdc28p substrate
similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Hypothetical ORF
similar to uniprot|Q12326 Saccharomyces cerevisiae YOL056W GPM3 and to YDL021W uniprot|Q12008 Saccharomyces cerevisiae YDL021W GPM2, Homologs of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis
weakly similar to uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses
weakly similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele
similar to uniprot|Q12451 Saccharomyces cerevisiae YDL019C OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability
similar to uniprot|P80235 YAR035W Saccharomyces cerevisiae YAT1 Outer carnitine acetyltransferase mitochondrial
weakly similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase promotes mitotic exit by directly switching on the kinase activity of Dbf2p
similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential protein kinase with unknown cellular role
highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenin
weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm binds rg-nuclear localization signals on Nab2p and Hrp1p plays a role in cell-cycle progression
similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression
similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C
similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p kinase activity correlates with cyclical DBF4 expression
similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 ER protein involved in very long chain fatty acid synthesis
similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W
similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W HEX3 Ring finger protein involved in the DNA damage response with possible recombination role genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase) sporulation role interacts with Slx8p and Lin1p
weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function potentially phosphorylated by Cdc28p
similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Hypothetical ORF
similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co-chaperone GimC/prefoldin complex which promotes efficient protein folding
weakly similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Hypothetical ORF
similar to uniprot|Q756P6 Ashbya gossypii AER208C AER208Cp and weakly similar to YGR077C uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Required for peroxisome assembly peroxisome associated protein containing a PTS1 signal
highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
highly similar to uniprot|Q06224 Saccharomyces cerevisiae YLR277C YSH1 subunit of Polyadenylation factor I (PF I)
similar to uniprot|Q74ZB9 Ashbya gossypii AGR280C AGR280Cp and some similarites with YLR278C uniprot|Q05854 Saccharomyces cerevisiae YLR278C Protein of unknown function localizes to the nucleus potential Cdc28p substrate
similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Hypothetical ORF
similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Hypothetical ORF
similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C ECI1 Peroxisomal delta3 delta2-enoyl-CoA isomerase hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl- CoA essential for the beta-oxidation of unsaturated fatty acids oleate-induced
similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N-methyltransferase has a role in rDNA silencing and in lifespan determination
similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor activates the Arp2/3 protein complex that nucleates branched actin filaments localizes with the Arp2/3 complex to actin patches homolog of the human Wiskott-Aldrich syndrome protein (WASP)
some similarities with uniprot|Q05881 Saccharomyces cerevisiae YLR287C Hypothetical ORF
similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C RPS30B and similar to uniprot|Q12087 Saccharomyces cerevisiae YLR287C-A RPS30A
highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 phosphoserine transaminase
similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 Involved in checkpoint control and DNA repair forms a clamp with Rad17p and Ddc1p that is loaded onto partial duplex DNA DNA damage checkpoint protein
highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial GTPase of unknown function
similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome
similar to uniprot|Q08908 Saccharomyces cerevisiae YOR384W
some similarities with uniprot|Q08907 Saccharomyces cerevisiae YOR383C
weakly similar to uniprot|Q04433 Saccharomyces cerevisiae YDR534c Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W
similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport interacts with Kap121p Kap123p and Pdr6p (karyophilin betas) Gsp1p homolog that is not required for viability
similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis
weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre-mRNA splicing
highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans
similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation
some similarities with uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p-MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4
uniprot|Q12628 Kluyveromyces lactis KLLA0C05324g Glucan 1 3-beta-glucosidase precursor
weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1)
some similarities with uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain
similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF
highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud-site selection protein Axl2p to cell surface related to Drosophila cornichon
some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability
some similarities with uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein
similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase
similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations
some similarities with uniprot|P53171 Saccharomyces cerevisiae YGL057C
highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF
weakly similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes
similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2
similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy
similar to uniprot|Q75ED7 Ashbya gossypii AAR161W DUO1 DASH complex subunit DUO1 and weakly similar to YGL061C uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis
highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase
similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Protein with sequence similarity to RNA polymerases; interacts with a DNA repair protein, Rad5p, in the two-hybrid system; may provide a link between recombination in direct repeats and transcription
weakly similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor
weakly similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger
similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin
uniprot|O59863 Kluyveromyces lactis KLLA0C05940g PLB Lysophospholipase precursor
similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate
highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0 A1 and A2 does not possess detectable RNA cyclase activity
similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae
similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF
similar to uniprot|Q03673 Saccharomyces cerevisiae YMR003W
similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF
similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I
similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C
highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C
similar to uniprot|Q75CF0 Ashbya gossypii ACL004W ACL004Wp and weakly similar to YOL004W uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation
similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC- CRD protein
similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes
similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C
mitochondrial 54S ribosomal protein YmL33
highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit
some similarities with uniprot|Q03208 Saccharomyces cerevisiae YML119W
similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae
highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle through its homolog and binding partner Gtr2p involved in phosphate transport and invasive growth human RagA and RagB proteins are functional homologs
similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases dispensable for cell growth and for mitochondrial respiration
highly similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Partner of Nob1 Protein required for cell viability
similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial Distribution and Morphology
similar to uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Required for final stages of splicesome maturation; promotes step 1 of splicing; spliceosome-associated protein
similar to uniprot|Q04172 YDR393W Saccharomyces cerevisiae SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology
highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates
similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Protein involved in glycosyl phosphatidyl inositol synthesis most likely an alpha 1 2 mannosyltransferase utilized for addition of the fourth side-branching mannose onto the GPI core structure
similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p,Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p
similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2)
similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of both inosine monophosphate and guanosine monophosphate mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
similar to uniprot|Q04179 YDR400W Saccharomyces cerevisiae URH1 uridine nucleosidase (uridine ribohydrolase)
similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall homologous to cytochrome P-450s
similar to uniprot|P21623 YDR403W Saccharomyces cerevisiae DIT1 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor
highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16 forms two subunit dissociable complex with Rpb4p
mitochondrial 54S ribosomal protein YmL44
similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability
similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF
similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W Hypothetical ORF
similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved
similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C
similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex required for SAGA-mediated deubiquitination of histone H2B
similar to uniprot|Q05015 Saccharomyces cerevisiae YMR222C FSH2 and similar to uniprot|Q99369 Saccharomyces cerevisiae YOR280C FSH3 Serine hydrolases
similar to Saccharomyces cerevisiae and to YMR222C uniprot|Q05015 Saccharomyces cerevisiae FSH2 Serine hydrolase
similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria
weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p
similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate
weakly similar to uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
similar to uniprot|Q756B5 Ashbya gossypii AER352C AER352Cp and weakly similar to YMR218C uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic
similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway
highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C
similar to uniprot|Q03655 Saccharomyces cerevisiae YMR215W GAS3 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall
similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog
similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control repressor of cap-dependent translation initiation competes with eIF4G for binding to eIF4E
similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p
similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation
similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms
similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W
similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF
highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein
highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF
similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate
similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1
some similarities with uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H()-ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis
similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein
similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria
weakly similar to uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF
similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation
similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF
some similarities with uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
weakly similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF
similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R
similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm
highly similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Integral membrane protein required for ER to Golgi transport
highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C RPS24B and highly similar to uniprot|P26782 Saccharomyces cerevisiae YER074W RPS24A proteins component of the small (40S) ribosomal subunit
highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme
highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance
weakly similar to uniprot|P40045 Saccharomyces cerevisiae YER071C
similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF
highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division
similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
some similarities with uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p
similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches
highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p
weakly similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog
similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C-terminal region of Not1p
highly similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C Hypothetical ORF
highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
weakly similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription
some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF
weakly similar to uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) (putative) involved in transcription
highly similar to uniprot|P41277 Saccharomyces cerevisiae RHR2 and to YER062C uniprot|P40106 Saccharomyces cerevisiae HOR2, two redundant DL-glycerol-3-phosphatases
similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase
similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth
similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 and similar to uniprot|Q12119 Saccharomyces cerevisiae YER060W-A FCY22, Purine-cytosine permeases
similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated and weakly similar to YER059W uniprot|P40038 Saccharomyces cerevisiae YER059W PCL6 Pho85p cyclin of the Pho80p subfamily forms the major Glc8p kinase together with Pcl7p and Pho85p involved in the control of glycogen storage by Pho85p stabilized by Elongin C binding
similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase
similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro
highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases
highly similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W
similar to uniprot|P37254 Saccharomyces cerevisiae YNR033W
highly similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 Ubiquitin-like protein modifier
similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases
similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p
highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability
mitochondrial 54S ribosomal protein IMG2
similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation
similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF
similar to gnl|GLV|DEHA0G11220g Debaryomyces hansenii DEHA0G11220g and weakly similar to YCR069W uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl- prolyl cis-trans isomerase (cyclophilin) catalyzes the cis- trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway
similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p
similar to uniprot|Q75EN0 Ashbya gossypii AAR049C RAD18 Postreplication repair ubiquitin-protein ligase E3 RAD18 and weakly similar to YCR066W uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif
weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly
highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 or uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 or uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3
similar to uniprot|P25638 Saccharomyces cerevisiae YCR060W TAH1 HSP90 cofactor interacts with Hsp82p Pih1p Rvb1 and Rvb2 contains a single TPR domain with at least two TPR motifs
similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN)
similar to uniprot|Q75EM3 Ashbya gossypii AAR056C AAR056Cp and weakly similar to YNR024w
highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein
weakly similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function
highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase
similar to uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex
similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation
similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF
similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF
similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF
similar to uniprot|P53629 Saccharomyces cerevisiae YNR019W ARE2 Acyl-CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p
similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function
similar to uniprot|Q8PPU9 Xanthomonas axonopodis pv XAC0586 Hypothetical protein XAC0586
some similarities with uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid; dihydroorotate dehydrogenase
highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C
similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p
highly similar to uniprot|P40510 Saccharomyces cerevisiae YIL074C and to uniprot|P40054 Saccharomyces cerevisiae YER081W SER3 3-phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p
similar to uniprot|P40511 Saccharomyces cerevisiae YIL073C SPO22
similar to uniprot|Q75FB1 Ashbya gossypii AAL180C AAL180Cp and weakly similar to YKR011C uniprot|Q02209 Saccharomyces cerevisiae YKR011C Hypothetical ORF
weakly similar to uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure
similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1
highly similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta-tubulin
weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein may help establish daughter fate
highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability
highly similar to uniprot|Q6Q5I7 Saccharomyces cerevisiae YOR261C
similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders
similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle
similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia
mitochondrial 54S ribosomal protein YmL40
similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p
weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued)
similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis mutations cause defects in transcription and in biogenesis of cell wall proteins
similar to uniprot|Q08693 Saccharomyces cerevisiae YOR256C Protein required for cell viability
highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis
weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers
similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP
similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat- shock resistance mating sporulation and telomeric silencing
some similarities with uniprot|Q12467 Saccharomyces cerevisiae YPL168W
similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF
similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage
weakly similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6
similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate
similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit
weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition
similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability
similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Hypothetical ORF
similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p
similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C Hypothetical ORF
similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C HNT2 Dinucleoside triphosphate hydrolase
similar to uniprot|Q75EY2 Ashbya gossypii AAL054W AAL054Wp and some similarites with YHR059W uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function required for survival upon exposure to K1 killer toxin
similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 RNA polymerase II transcriptional regulation mediator RNA polymerase II mediator subunit
similar to uniprot|P35176 Saccharomyces cerevisiae YDR304C CPR5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER
similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate human PIG-Fp is a functional homolog; GPI11 ER membrane protein
similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 Functions in cleavage of 3'-ends of pre-mRNAs prior to polyadenylation 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) Component of pre-mRNA cleavage factor II (CFII) 150-kDa protein associated with polyadenylation factor 1 (PF I)
highly similar to uniprot|P32264 Saccharomyces cerevisiae YDR300C PRO1 Gamma-glutamyl kinase catalyzes the first step in proline biosynthesis and to YHR033W uniprot|P38690 Saccharomyces cerevisiae YHR033W Hypothetical ORF
similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function may function in protein folding and/or rRNA processing interacts with a chaperone (Hsp82p) two chromatin remodeling factors (Rvb1p Rvb2p) and two rRNA processing factors (Rrp43p Nop58p)
similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C
similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein possibly involved in secretion multicopy suppressor of sensitivity to Brefeldin A
uniprot|O74190 Kluyveromyces lactis KLLA0C10384g ATP5 ATP synthase subunit 5, mitochondrial precursor
similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphingosine hydroxylase has a role in sphingolipid metabolism catalyses the conversion of sphinganine to phytosphingosine
similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus binds to activation domains of acidic activators required for recombination-dependent mtDNA partitioning
weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Hypothetical ORF
similar to uniprot|Q06629 YDR295C Saccharomyces cerevisiae YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda3p; Ploidy-related
similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) degrades phosphorylated long chain bases prefers C16 dihydrosphingosine-l-phosphate as a substrate
similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W Protein required for cell viability
highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase
similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Protein with a role in maintenance of cellular integrity interacts with components of the TOR pathway ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Ribosomal Recycling Factor 1 originally characterized as FIL1 a Factor for Isocitrate Lyase expression mitochondrial ribosome recycling factor
similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Vacuolar H+ ATPase subunit G of the catalytic (V1) sector
similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA
weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit contain GTPase domains involved in SRP-dependent protein targeting interacts with SRP102p
similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W Hypothetical ORF
similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Regulator of Ty1 Transposition regulator of Ty1 Transposition
similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 RNA polymerase II holoenzyme/mediator subunit
similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation activated by uncharged tRNAs and the Gcn1p-Gcn20p complex
similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc- regulated vacuolar membrane-associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell metabolism
similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W
weakly similar to uniprot|P31111 Saccharomyces cerevisiae YDR285W ZIP1 Synaptonemal complex (SC) protein that connects homologous chromosomes partially during zygotene and entirely during pachytene potential Cdc28p substrate synaptonemal complex protein
similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Hypothetical ORF
weakly similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p
similar to YLR015W, uniprot|P43132 Saccharomyces cerevisiae YLR015W (BRE2)
similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting NeXin
similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p
highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W
highly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase
similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Hypothetical ORF
weakly similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit required for RNase H2 activity
highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases
similar to uniprot|P38773 Saccharomyces cerevisiae and to YHR044C uniprot|P38774 Saccharomyces cerevisiae DOG1 2- deoxyglucose-6-phosphate phosphatase
similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Hypothetical ORF
similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function expression is regulated by phosphate levels green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Translation release factor involved in translation termination mutant form acts as a recessive omnipotent suppressor
similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus involved in biogenesis of large (60S) ribosomal subunits
similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Hypothetical ORF
putative mitochondrial 37S ribosomal protein SWS2
similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2
similar to uniprot|P14242 Saccharomyces cerevisiae, YNL082W
similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage
similar to uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 Probable transporter member of the Ca2 - binding subfamily of the mitochondrial carrier family with two EF-hand motifs Pet9p and Sal1p have an overlapping function critical for viability polymorphic in different S. cerevisiae strains
some similarities with uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells localizes to the incipient bud site and bud neck glycosylated by Pmt4p potential Cdc28p substrate
similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p
highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo
similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8
some similarities with uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre-rRNA processing and ribosome biogenesis
some similarities with YGR161c, uniprot|Q7ZA12 Saccharomyces cerevisiae Hypothetical ORF, RTS3 SGDID:S0003393
similar to uniprot|Q752T1 Ashbya gossypii AFR492W AFR492Wp and weakly similar to YGL021W uniprot|P43633 Saccharomyces cerevisiae YGL021W ALK1 leucine zipper (putative) membrane protein (putative) and YBL009W uniprot|P32789 Saccharomyces cerevisiae YBL009W haspin
weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C
similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen
similar to uniprot|P32656 Saccharomyces cerevisiae YER163C Hypothetical ORF
highly similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF
similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane
similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH involved in transcription initiation homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair
similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex
uniprot|Q01072 Kluyveromyces lactis KLLA0C11781g RAG3 RAG3 protein
weakly similar to uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase
similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8
similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
some similarities with uniprot|P40095 Saccharomyces cerevisiae YER158C
similar to gnl|GLV|DEHA0E23727g Debaryomyces hansenii DEHA0E23727g and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway
some similarities with uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex homologous to human NC2alpha
similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) involved in transfer of secretory precursors through the endoplasmic reticulum membrane endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex
similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 involved in processing rRNA precursor species to mature rRNAs involved in rRNA processing
similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
similar to uniprot|Q754A8 Ashbya gossypii AFR164W AFR164Wp and some similarites with YGL105W uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids
similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF
mitochondrial 54S ribosomal protein YmL10/YmL18
similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
some similarities with uniprot|Q12215 Saccharomyces cerevisiae YOL105C WSC3 cell wall integrity and stress response component 3 Putative integral membrane protein containing novel cysteine motif
similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends
similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus
weakly similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl-myriocin
similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
weakly similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p
highly similar to uniprot|P30606 Saccharomyces cerevisiae YOL103W ITR2 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
pumilio-family RNA binding domain-containing protein
similar to uniprot|Q04373 YDR496C Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences
weakly similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein
weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation
similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase
similar to uniprot|Q03429 YDR493W Saccharomyces cerevisiae YDR493W FMP36
similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc
similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis
similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex
highly similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A
weakly similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain-containing protein required for cytokinesis
similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W
some similarities with uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin-dependent kinases
highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology
some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII
similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p
highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF
similar to uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p
similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain
similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA-binding zinc knuckle motif
similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition
similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
weakly similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport
similar to uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing
similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF
similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source
some similarities with uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin
weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids
similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS)
similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability
weakly similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF
some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
weakly similar to uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p
similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog
similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W Hypothetical ORF
weakly similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced
highly similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA
similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins
similar to uniprot|P01120 Saccharomyces cerevisiae YNL098C RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
some similarities with uniprot|P50947 Saccharomyces cerevisiae YNL097C
similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta- oxidation
similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O-and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family
weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit involved in protein import/export and in export of RNAs possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC potential Cdc28p substrate
highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W
similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase
highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor GTPase of the Ras superfamily involved in development of polarity
similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Hypothetical ORF
similar to gnl|GLV|CAGL0G06468g Candida glabrata CAGL0G06468g and some similarites with YOR092W uniprot|Q99252 Saccharomyces cerevisiae YOR092W ECM3 Non-essential protein of unknown function
similar to uniprot|Q75CK0 Ashbya gossypii ACL081C ACL081Cp and weakly similar to YNL094W uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function interacts with Rvs161p and Rvs167p computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W RBF46 Hypothetical ORF
similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrially localized type 2C protein phosphatase contains Mg2 /Mn2 -dependent casein phosphatase activity in vitro but in vivo substrates are unknown
highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C VPS21 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization geranylgeranylated geranylgeranylation required for membrane association
similar to uniprot|P53934 Saccharomyces cerevisiae YNL092W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
similar to uniprot|Q12324 Saccharomyces cerevisiae YOR088W/YOR087W YVC1 Vacuolar cation channel
some similarities with uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function mediates sensitivity to salt stress interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity and in microtubule assembly
similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Essential type II topoisomerase catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone localizes to axial cores in meiosis
similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C TCB1 Contains three calcium and lipid binding domains green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C-terminal portion of Tcb1p Tcb2p and Tcb3p interact
similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W Hypothetical ORF
similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N- glycosylation of a subset of proteins
similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease
similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C PRP12 Integral inner mitochondrial membrane protein with similarity to exonucleases
similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C Homolog to human PPAT
weakly similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Essential protein component of a complex containing Cef1p has similarity to S. pombe Cwf22p putative spliceosomal component based on computational analysis of large-scale protein-protein interaction data
similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C
similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
similar to uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Protein with a role in maturation of rRNAs and small nucleolar RNAs required for cell viability
similar to uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex acts as the nuclear import receptor for specific proteins including Pdr1p Yap1p Ste12p and Aft1p
weakly similar to uniprot|P25611 Saccharomyces cerevisiae YCR106W RDS1 Regulator of drug sensitivity transcriptional regulator
similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane transporter of the ATP-binding cassette (ABC) family mediates export of many different organic anions including oligomycin
similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations
similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway
highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Hypothetical ORF
similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W
similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C Hypothetical ORF
similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N- acetylglucosaminyltransferase capable of modification of N- linked glycans in the Golgi apparatus
similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W
similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase
similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism involved in response to oxidative stress
similar to uniprot|P38248 Saccharomyces cerevisiae YBR078w and to uniprot|Q12355 Saccharomyces cerevisiae YDR055w
similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport homolog of the mammalian NSF
similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes binds phosphatidylinositol(3)-phosphate contains a FYVE finger domain
similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature
similar to uniprot|Q12153 Saccharomyces cerevisiae YDR312W SSF2 high copy suppressor of G beta subunit temperature sensitive mutation possibly involved in mating
highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA RRP3 is a DEAD box gene homologous to eIF-4a which encodes an RNA-dependent ATPase possessing helicase activity which is not specific for RNA
similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes required for nucleotide excision repair target for transcriptional activators
similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 DnaK homolog interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit Hsp70 Protein
similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase part of the pantothenic acid pathway structurally homologous to E. coli panE
some similarities with uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Suppressor of mar1-1 (sir2) mutation nuclear protein involved in silencing
similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends
weakly similar to uniprot|Q06648 Saccharomyces cerevisiae YDR309C GIC2 Protein of unknown function involved in initiation of budding and cellular polarization interacts with Cdc42p via the Cdc42/Rac- interactive binding (CRIB) domain
weakly similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex
similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 RNA polymerase II holoenzyme component
weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Hypothetical ORF
highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W
similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W Hypothetical ORF
similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Hypothetical ORF
some similarities with uniprot|Q2V2P7 Saccharomyces cerevisiae YDR461C-A
mitochondrial 54S ribosomal protein YmL28
similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit
weakly similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W
some similarities with uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p may partially counteract the action of Vps33p and vice versa localizes to the rim of the vacuole as cells approach stationary phase
similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
weakly similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C Hypothetical ORF
uniprot|P78698 Kluyveromyces lactis KLLA0C15059g HEM1 5- aminolevulinate synthase mitochondrial precursor
similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C RTN1 reticulon gene member of the RTNLA (reticulon-like A) subfamily
highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase catalyzes the conversion of homocitrate to homoisocitrate which is a step in the lysine biosynthesis pathway
similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Phorphobilinogen deaminase catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane the third step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus expression is regulated by Hap2p-Hap3p
similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing required for U1 snRNP biogenesis contains multiple tetriatricopeptide repeats
weakly similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function
similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase phosphorylates riboflavin to form riboflavin monophosphate (FMN) which is a necessary cofactor for many enzymes localizes to microsomes and to the mitochondrial inner membrane
similar to uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import component of Nup82p nuclear pore subcomplex contains a nuclear export signal
mitochondrial 54S ribosomal protein YmL7/YmL5
highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Involved in endoplasmic-to-Golgi protein trafficking encodes a subunit of yeast coatomer
weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Hypothetical ORF
weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 U1 snRNP protein serine-rich has no counterpart in mammalian U1 snRNP
similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins essential for function of H/ACA-type snoRNPs which are involved in 18S rRNA processing
similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C
similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family involved in RNA isomerization at the 5' splice site
similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Essential for import of proteins with SKL-like import signal into peroxisomal matrix 69-kDa protein containing tetratricopeptide repeat (TPR)
uniprot|Q70KX5 Kluyveromyces lactis mnn10 Golgi mannosyltransferase complex subunit
similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W mitochondrial protein
similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C
highly similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Translocase of Outer Mitochondrial membrane
highly similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Hypothetical ORF
some similarities with uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Suppressor of Ypt3
similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 essential zinc finger protein
similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Protein involved in a putative alcohol-responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain
similar to uniprot|Q75DC1 Ashbya gossypii ABR105C ABR105Cp and weakly similar to YGR080W uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin A member of a conserved family of actin monomer sequestering proteins comprised almost entirely of two tandem repeats each having sequence homology with cofilin (Cof1p)
some similarities with uniprot|P53249 Saccharomyces cerevisiae YGR079W
C/D snoRNA polycistronic Cluster 3 SNR41
C/D snoRNA polycistronic Cluster 3 SNR70
C/D snoRNA polycistronic Cluster 3 SNR51
similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Hypothetical ORF
similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Central regulator of the Mec1p/Tel1p signaling network; required for mitotic growth, DNA repair and mitotic recombination, regulates phosphorylation of Rad53p, required for dmc1 arrest and meiotic recombination; similar to phosphatidylinositol (PI)3- kinases required for DNA damage induced checkpoint responses in G1, S/M, intra S, and G2/M in mitosis
highly similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Subunit of the Cdc28 protein kinase required for mitotic proteolysis may also be involved in the proteolysis of the G1 cyclins
similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase, bud neck localization
similar to uniprot|O13585 Saccharomyces cerevisiae YPR089W Hypothetical ORF
similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 Plasma membrane carnitine transporter expression is down-regulated by osmotic stress also functions as a low-affinity amino acid permease
highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue
highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'
weakly similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
similar to uniprot|P39926 Saccharomyces cerevisiae YMR183C SSO2 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE
similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities
some similarities with uniprot|Q12132 Saccharomyces cerevisiae YPL230W USV1 Up in StarVation
weakly similar to uniprot|Q99395 Saccharomyces cerevisiae YPL229W Hypothetical ORF
similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase
similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum
weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2 but not required at the other histone loci functionally related to Spt10p
similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU]
similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF
highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF
similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p
similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks
weakly similar to uniprot|Q08969 Saccharomyces cerevisiae YPL223C Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck
similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF
highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid
similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre-18S rRNA
similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre-autophagosomal structure and other cytosolic punctate structures not found in autophagosomes
similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53
similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing
similar to uniprot|Q12175 Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis msh5-Y823H mutation confers tolerance to DNA alkylating agents homologs present in C. elegans and humans
similar to uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 Involved in mitotic induction G(sub)2-specific B-type cyclin and uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3
similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1 2-mannosyltransferase responsible for addition of the second alpha-1 2-linked mannose of the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment
similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF
similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF
similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF
similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway
similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation
similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides
highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles
similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1
highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs which are required for pseudouridylation and processing of pre-18S rRNA
highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore
some similarities with uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability
highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C TUB1 Alpha-tubulin associates with beta-tubulin (Tub2p) to form tubulin dimer which polymerizes to form microtubules
highly similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1 4-lactone oxidase catalyzes the final step in biosynthesis of D-erythroascorbic acid which is protective against oxidative stress
similar to uniprot|Q12746 Saccharomyces cerevisiae YML125C Protein required for cell viability
similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex binds to phosphorylated Ho endonuclease allowing its ubiquitylation by SCF and subsequent degradation
similar to uniprot|P54791 Saccharomyces cerevisiae YPR162C ORC4 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C
similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Cystathionine beta-lyase converts cystathionine into homocysteine
weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Hypothetical ORF
similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division forms a complex with Hop2p which is involved in chromosome pairing and repair of meiotic double-strand breaks
some similarities with uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Contains a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus regulates ultradian rhythm cell size cell cycle lifespan sporulation heat tolerance and multidrug transport
similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein serine/threonine kinase required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
some similarities with uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall
similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes
similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway required for normal vacuole morphology cell wall integrity and actin cytoskeleton organization
highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy
weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate
similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis
similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase
similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway
uniprot|Q70SJ1 Kluyveromyces lactis pcl1 Putative carboxypeptidase-related protein
highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p
similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C
highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Predicted ABC family ATPase required for translation initiation facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit may have a role in large ribosomal subunit biogenesis
similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain Helicase domain and DNA-binding domain transcriptional regulator
similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein part of the 3'-end RNA-processing complex mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail involved in control of poly(A) tail length interacts with translation factor eIF-4G
highly similar to uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue DNA damage triggers redistribution from the cytoplasm to the nucleus
similar to uniprot|P32660 Saccharomyces cerevisiae YER166W DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the plasma membrane and late exocytic or early endocytic membranes likely involved in protein transport
some similarities with uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway which controls cell integrity overproduction suppresses pkc1 mutations
uniprot|Q9HGK5 Kluyveromyces lactis CCA1 TRNA nucleotidyltransferase
similar to uniprot|Q74ZT1 Ashbya gossypii AGR117C AGR117Cp and some similarites with YER169W uniprot|P39956 Saccharomyces cerevisiae YER169W RPH1 Transcriptional repressor of PHR1 which is a photolyase induced by DNA damage binds to AG(4) (C(4)T) sequence upstream of PHR1 Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs potentially phosphorylated by Cdc28p
similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase catalyzes the reversible synthesis of GTP and AMP from GDP and ADP may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions 3' sequence of ADK2 varies with strain background
highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase involved in nucleotide excision repair and transcription subunit of RNA polymerase II transcription initiation factor TFIIH subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein
similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis
similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints subunit of a clamp loader that loads Rad17p- Mec3p-Ddc1p onto DNA homolog of human and S. pombe Rad17 protein
similar to uniprot|Q03835 Saccharomyces cerevisiae YDR098C GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage
similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase
weakly similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W
similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Hypothetical ORF
similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Hypothetical ORF
some similarities with uniprot|P32334 Saccharomyces cerevisiae YGR014W MSB2 Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway also functions as an osmosensor in parallel to the Sho1p-mediated pathway potential Cdc28p substrate
weakly similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP contains few SR- RE- and RD-dipeptides U1 snRNP protein
similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF
highly similar to uniprot|Q06178 Saccharomyces cerevisiae YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase involved in NAD() salvage pathway
similar to uniprot|Q06177 Saccharomyces cerevisiae YLR327C RBF9 Hypothetical ORF
similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase
similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF
some similarities with uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing recruited to the spliceosome by Slu7p
similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 transcription initiation factor TFIIF middle subunit
highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit
similar to uniprot|Q06169 Saccharomyces cerevisiae YLR324W PEX30 Peroxisomal integral membrane protein involved in negative regulation of peroxisome number partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
similar to uniprot|Q752S4 Ashbya gossypii AFR499C CWC24 Pre-mRNA-splicing factor CWC24 and some similarites with YLR323C uniprot|P53769 Saccharomyces cerevisiae
similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W
similar to uniprot|Q752S6 Ashbya gossypii AFR497C SWC4 SWR1-complex protein 4 and weakly similar to YGR002C uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin component of the NuA4 histone acetyltransferase complex
weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein involved in resistance to ionizing radiation acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks
similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein involved in actin cable nucleation and polarized cell growth isolated as bipolar budding mutant potential Cdc28p substrate
similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme essential for telomerase core catalytic activity involved in other aspects of telomerase assembly and function
similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p
similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Involved in chromatin modeling cell cycle progression homolog of Snf5p member of the chromatin remodeling complex RSC
highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta
similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 involved in vacuolar protein sorting required for localization and trafficking of the CPY sorting receptor Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2 binding motif.
highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability
similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate and to YCR091W uniprot|P25341 Saccharomyces cerevisiae YCR091W KIN82 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability
similar to uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels
similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity
highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD) component of the cellular stress response
similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF
similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF
similar to uniprot|Q9UVP9 Saccharomyces kluyveri Hypothetical protein and some similarites with YNR049C uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of the secretory vesicle docking complex acts at a late step in secretion shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions required for sporulation
highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming)
similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
some similarities with uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor
similar to uniprot|P39008 YNR052C Saccharomyces cerevisiae POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
highly similar to uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
some similarities with uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing
similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Hypothetical ORF
similar to uniprot|Q59UP3 Candida albicans DUR34 Potential urea active transport protein and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway
uniprot|Q874B4 Kluyveromyces lactis KLLA0C18931g Drug efflux permease KNQ1
some similarities with uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type
highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF
similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease
highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) member of a subtelomeric gene family including THI5 THI11 THI12 and THI13
weakly similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression
similar to uniprot|Q5MBU0 Aspergillus fumigatus gliC GliC
similar to uniprot|P53749 Saccharomyces cerevisiae YNR063W Hypothetical ORF
similar to uniprot|P53748 Saccharomyces cerevisiae YNR062C Hypothetical ORF
similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter or YHL040C uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C
some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C
some similarities with uniprot|P53054 Saccharomyces cerevisiae YGL262W Hypothetical ORF
similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid dihydroorotate dehydrogenase
similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W
some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
weakly similar to uniprot|Q55924 Synechocystis sp slr0317 Slr0317 protein