Kluyveromyces lactis strain NRRL Y-1140 chromosome B complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Submitted (25-SEP-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (09-SEP-2008) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CR382122.\nThis is an updated version of the complete genome sequence. The\nKluyveromyces lactis sequence is made of 6 chromosomes (A to F).\nThe sequence was annotated by the Genolevures Consortium. For more\ninformation go to\nhttp://cbi.labri.fr/Genolevures.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport
similar to uniprot|Q08295 Saccharomyces cerevisiae YOL157C
uniprot|Q9Y845 Kluyveromyces lactis mal21 Maltose permease
similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W
highly similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W
similar to uniprot|P53744 Saccharomyces cerevisiae YNR056C BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway responsible for uptake of 7-keto 8-aminopelargonic acid BIO5 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis
similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels
similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis
weakly similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase
some similarities with uniprot|Q12034 Saccharomyces cerevisiae YDR515W SLF1 Associates with translating ribosomes
similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ABC1 Protein required for ubiquinone (coenzyme Q) biosynthesis which in turn is required for respiratory growth
highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome
uniprot|Q00995 Kluyveromyces lactis FOG1 protein
similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 associated with U1 U2 U4 and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs U1 snRNP protein
similar to uniprot|P40019 Saccharomyces cerevisiae YER030W
highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT31
similar to uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
some similarities with uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Cytoplasmic protein of unknown function transcription is induced under conditions of zinc deficiency
some similarities with uniprot|P53088 Saccharomyces cerevisiae YGL211W NCS6 Protein with a role in urmylation and in invasive and pseudohyphal growth
some similarities with uniprot|P28742 Saccharomyces cerevisiae YBL063W KIP1 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein microtubule motor protein
weakly similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes
similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W
similar to uniprot|Q04067 YDR429C Saccharomyces cerevisiae TIF35 Subunit of the core complex of translation initiation factor 3(eIF3)
mitochondrial 54S ribosomal protein YmL39
similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P27692 YML010W Saccharomyces cerevisiae SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation
similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C
similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1 Erp2p and Emp24 member of the p24 family involved in endoplasmic reticulum to Golgi transport
similar to uniprot|P32898 YDR430C Saccharomyces cerevisiae CYM1 Cytosolic metalloprotease
weakly similar to uniprot|Q01560 YDR432W Saccharomyces cerevisiae NPL3 RNA-binding protein that carries poly(A) mRNA from the nucleus into the cytoplasm
uniprot|Q7ZA19 Kluyveromyces lactis sel1 Secretion lowering protein
similar to uniprot|P49957 YML014W Saccharomyces cerevisiae TRM9 tRNA methyltransferase
similar to uniprot|Q04080 YDR434W Saccharomyces cerevisiae GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins
similar to uniprot|Q04226 YML015C Saccharomyces cerevisiae TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation
similar to uniprot|Q04081 YDR435C Saccharomyces cerevisiae PPM1 Carboxyl methyl transferase
some similarities with uniprot|P26570 Saccharomyces cerevisiae YML016C PPZ1 Serine/threonine protein phosphatase Z isoform of Ppz2p involved in regulation of potassium transport
similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W Protein required for cell viability
weakly similar to uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing
similar to uniprot|Q03730 YML018C Saccharomyces cerevisiae
similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W
some similarities with uniprot|Q04087 Saccharomyces cerevisiae YDR439W
similar to uniprot|Q03722 YML020W Saccharomyces cerevisiae
similar to uniprot|P12887 YML021C Saccharomyces cerevisiae UNG1 uracil DNA glycosylase
similar to uniprot|Q04089 YDR440W Saccharomyces cerevisiae DOT1 Nucleosomal histone H3-Lys79 methylase
similar to uniprot|P49435 YML022W Saccharomyces cerevisiae APT1 Adenine phosphoribosyltransferase
weakly similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Protein required for cell viability
similar to uniprot|P38931 YDR443C Saccharomyces cerevisiae SSN2 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme
similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W
similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane
weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein of unknown function GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis may be involved in maintaining chromatin structure
highly similar to uniprot|P02407 Saccharomyces cerevisiae YML024W RPS17A and to uniprot|P14127 Saccharomyces cerevisiae YDR447C RPS17B Ribosomal proteins 51 (rp51) of the small (40s) subunit
highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
mitochondrial 54S ribosomal protein YmL6
similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P35271 Saccharomyces cerevisiae YML026C RPS18B and to uniprot|P35271 Saccharomyces cerevisiae YDR450W RPS18A proteins component of the small (40S) ribosomal subunit
weakly similar to uniprot|P34161 Saccharomyces cerevisiae YML027W YOX1 Homeodomain-containing transcriptional repressor binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase expression is cell cycle-regulated potential Cdc28p substrate
similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism functions as a homodimer
highly similar to uniprot|P34760 Saccharomyces cerevisiae YML028W TSA1 and to uniprot|Q04120 Saccharomyces cerevisiae YDR453C TSA2 Thioredoxin- peroxidase
some similarities with uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Protein that interacts in the two-hybrid system with the U1 snRNP-specific protein Snp1p may have a role in pre-mRNA splicing
similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W
similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Endosomal Na+/H+ exchanger
similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains
uniprot|P41768 Kluyveromyces lactis KLLA0B01782g RAD52 DNA repair and recombination protein RAD52
similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 Temperature dependent Organization in Mitotic nucleus
similar to uniprot|Q03707 Saccharomyces cerevisiae YML034W SRC1
similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria
weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria
similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation
weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C
highly similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer
similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit
some similarities with uniprot|P53124 Saccharomyces cerevisiae YGL134W PCL10 Pho85p cyclin recruits activates and targets Pho85p cyclin-dependent protein kinase to its substrate
highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport
similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p
some similarities with uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a-specific genes repression of early meiotic genes during mitotic growth and repression of INO1
similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex
similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities
weakly similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein
similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2
highly similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit
mitochondrial 37S ribosomal protein RSM23
similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis intranuclear protein which exhibits a nucleotide-specific intron-dependent tRNA pseudouridine synthase activity
highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis
weakly similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane
similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function
similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate
similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W
similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2-PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation
some similarities with uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex
similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function
similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response
similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome
similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP-binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2
similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud
weakly similar to uniprot|P34231 Saccharomyces cerevisiae YKL187C and weakly similar to uniprot|Q06689 Saccharomyces cerevisiae YLR413W
similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA
weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate
similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase
similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature
highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities
similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W
highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes
similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Homologous to S. pombe asp1
highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data
similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis
similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3
highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit
highly similar to uniprot|Q757D8 Ashbya gossypii AER075W AER075Wp and similar to YLR405W uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p
similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain
weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W
weakly similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W
similar to uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress-responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies
similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region
similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein
similar to uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p
uniprot|Q9Y761 Kluyveromyces lactis KLLA0B03135g GNT1 Glucose N-acetyltransferase 1-A
uniprot|Q00974 Kluyveromyces lactis KLLA0B03157g YEA4 UDP-N-acetylglucosamine transporter YEA4
similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase
similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs
weakly similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting
highly similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
highly similar to uniprot|Q757F1 Ashbya gossypii AER062C AER062Cp and similar to YLR395C uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain
some similarities with uniprot|Q06032 Saccharomyces cerevisiae YLR394W CST9 Protein required for synaptonemal complex formation may have a role in meiotic recombination localizes to synapsis initiation sites on meiotic chromosomes potential Cdc28p substrate
highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation
some similarities with uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy
similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers
highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin Myo1p binds to an IQ motif of Myo1p localization to the bud neck depends on Myo1p involved in the disassembly of the Myo1p ring
similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain
similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82
similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2
similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts
similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B
similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W
uniprot|Q00970 Kluyveromyces lactis KLLA0B03740g MGM101 Mitochondrial genome maintenance protein MGM101 mitochondrial precursor
similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase
similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W
similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix
weakly similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W essential protein
similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor
similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1
similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome
similar to sp|P47169 Saccharomyces cerevisiae YJR137c ECM17 Sulfite reductase [NADPH] beta subunit involved in amino acid biosynthesis transcription repressed by methionine
similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C
highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space import protein
weakly similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance
similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein
similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild-type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus
highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine Phosphoribosyl Transferase
similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog
similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology
similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes
similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W
similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane
similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine
similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase
similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase
similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W
similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17
similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin)
similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70
highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria
similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p
similar to uniprot|Q03630 Saccharomyces cerevisiae YML077w BET5 involved in targeting and fusion of ER to golgi transport vesicles singleton
similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor
similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae
highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae
highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W
similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact
similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex
highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d
some similarities with uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis
highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation
highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation
some similarities with uniprot|Q06201 Saccharomyces cerevisiae YLR445W Hypothetical ORF
similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles
weakly similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly
similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7
uniprot|P54788 Kluyveromyces lactis KLLA0B05016g ORC1 Origin recognition complex subunit 1
similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily
highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit
similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion
similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA
similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA
mitochondrial 54S ribosomal protein YmL4
similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay
similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine
highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive
similar to uniprot|Q6HIN8 Bacillus thuringiensis subsp BT9727_2262 Hypothetical protein
weakly similar to uniprot|O13577 Saccharomyces cerevisiae YLR437C
some similarities with uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function
similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing
similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein
highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 or to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 or to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate
highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C
mitochondrial 54S ribosomal protein YmL41
similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W
highly similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS) interacts with nucleoporins to guide transport across the nuclear pore complex
similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER cleaves the anhydride linkage in Dol-P-P required for Dol-P-P- linked oligosaccharide intermediate synthesis and protein N-glycosylation
similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W
highly similar to uniprot|P05743 Saccharomyces cerevisiae YLR344W
similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C FMP17 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p
highly similar to uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 Catalytic subunit of 1 3-beta-D-glucan synthase functionally redundant with alternate catalytic subunit Gsc2p binds to regulatory subunit Rho1p involved in cell wall synthesis and maintenance localizes to sites of cell wall remodeling or uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2
similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W
highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends
some similarities with YLR337C uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Involved in cytoskeletal organization and cellular growth Proline-rich protein verprolin
similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space has a role in the maturation of cytosolic iron-sulfur proteins ortholog of human hepatopoietin (ALR)
highly similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane-spanning ATPase
some similarities with uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Suppressor of Glycerol Defect may be involved in high osmolarity signaling pathway
weakly similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Protein involved in nucleocytoplasmic transport binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization
similar to uniprot|Q3E792 Saccharomyces cerevisiae YGR027C
C/D snoRNA polycistronic Cluster 2 SNR57
C/D snoRNA polycistronic Cluster 2 SNR55
C/D snoRNA polycistronic Cluster 2 SNR61
similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage essential enzyme conserved among eukaryotes
highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I subunit A135
some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization
similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data
similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles
weakly similar to uniprot|P23493 Saccharomyces cerevisiae YKL093W MBR1 Protein involved in mitochondrial functions and stress response
similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons
similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types
uniprot|P24859 Kluyveromyces lactis KLLA0B06479g SEC14 SEC14 cytosolic factor
similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake
similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP-binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes
highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p
uniprot|Q7Z8M5 Kluyveromyces lactis CDC14
similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p
similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C
similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone
similar to YDR019C, uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1)
similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)
similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C
similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids
similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating
uniprot|P49377 Kluyveromyces lactis KLLA0B06886g ATP3 ATP synthase gamma chain mitochondrial precursor
some similarities with uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats
similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore
similar to uniprot|Q08913 Saccharomyces cerevisiae YPL279C and similar to YOR390w
highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism
weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity
highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery
highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs including Npl3p and Hrp1p thus facilitating nuclear export of these proteins required for viability of npl3 mutants
highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap
weakly similar to uniprot|P38222 Saccharomyces cerevisiae YBR030W
mitochondrial 54S ribosomal protein MRP49
similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation
similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C TPK3 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit and to YJL164C uniprot|P06244 Saccharomyces cerevisiae YJL164C TPK1 putative catalytic subunit of cAMP-dependent protein kinase
similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C
highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes
some similarities with uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain
weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161w
similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats
similar to uniprot|P47001 Saccharomyces cerevisiae YJL158C CIS3 cik1 suppressor Protein with homology to Hsp150p and Pir1p Pir2p and Pir3p
some similarities with uniprot|P21268 Saccharomyces cerevisiae YJL157C FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone also forms a complex with Cdc24p Ste4p and Ste18p that may specify the direction of polarized growth during mating potential Cdc28p substrate
similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2 6-bisphosphatase required for glucose metabolism
similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Protein involved in vacuolar sorting retromer complex component
similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase degrades reactive oxygen species in mitochondria involved in the response to oxidative stress
similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity localizes to the nucleus and to the daughter side of the mother-bud neck homolog of S. pombe Wee1p potential Cdc28p substrate
highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit
uniprot|P27069 Kluyveromyces lactis KLLA0B07623g RPS14 40S ribosomal protein S14
similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 suppressor of pma1-7
some similarities with uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1
similar to uniprot|P39542 Saccharomyces cerevisiae YJL193W
highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA
similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration
similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis
similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP
highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches
similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins
some similarities with YLR368W MDM30 F-box protein
similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C
some similarities with uniprot|P53243 Saccharomyces cerevisiae YGR067C
highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter
similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W
uniprot|P81205 Kluyveromyces lactis KLLA0B07997g SPT4 Transcription elongation factor SPT4
uniprot|P78990 Kluyveromyces lactis KLLA0B08019g COX18 Inner membrane protein COX18 mitochondrial precursor
similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A
highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol
similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway
similar to uniprot|P41901 Saccharomyces cerevisiae YGR059W SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes regulated by ABFI septin protein involved in sporulation
similar to uniprot|P53238 Saccharomyces cerevisiae YGR058W
highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit
similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C
similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W
similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs
some similarities with uniprot|Q752K9 Ashbya gossypii AFR565C AFR565Cp
uniprot|P87250 Kluyveromyces lactis KLLA0B08283g MTF1 Mitochondrial replication protein MTF1
some similarities with uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation
similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator
highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP()-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids
similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C
highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase involved in salvage pathways of pyrimidine metabolism
similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C JID1 Probable Hsp40p co-chaperone has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain inhibits replication of Brome mosaic virus in S. cerevisiae
highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family
weakly similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs required for pre-mRNA splicing and snRNP biogenesis in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed
similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W
similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C
similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C
uniprot|Q9Y787 Kluyveromyces lactis KLLA0B08657g PET111 COX2 mRNA-specific translational activator Pet111
weakly similar to uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p-binding protein
highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W
similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C
similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase
highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Probable regulator of glucose influx into the cell & into glycolytic pathway indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein 56 kD synthase subunit of trehalose-6-phosphate synthase/phosphatase complex
similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC)
mitochondrial 54S ribosomal protein YmL36
similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 component of the U4/U6aU5 tri-snRNP
highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C GRS1 glycyl-tRNA synthase
similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Translational activator of COB mRNA
similar to uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein homolog of human U1-A involved in nuclear mRNA splicing
highly similar to uniprot|P02994 Saccharomyces cerevisiae YPR080W TEF1 functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes translational elongation factor EF-1 alpha
similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein
uniprot|P49384 Kluyveromyces lactis KLLA0B09064g ADH3 Alcohol dehydrogenase III mitochondrial precursor
some similarities with sgd|S0006279 uniprot|Q6B149 Saccharomyces cerevisiae YPR075c OPY2 pheromone resistant yeast 2
uniprot|Q12630 Kluyveromyces lactis KLLA0B09152g TKL1 Transketolase
similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 phosphatase
similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of global transcriptional regulator
uniprot|Q8NJ21 Kluyveromyces lactis lys2 Alpha-aminoadipate reductase
highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family
highly similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor acts together with Tup1p also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A SUS1 Protein involved in mRNA export coupled transcription activation component of the SAGA histone acetylase complex
similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C
similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 transcriptional regulator
highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 biosynthesis of spermidine putrescine aminopropyltransferase (spermidine synthase)
similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C HOS1 Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p complex
similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase in the endoplasmic reticulum
uniprot|O60041 Kluyveromyces lactis KLLA0B09427g CMD1 Calmodulin
similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W Protein interacting with Rsv167p
similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2
similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation GFP-fusion protein localizes to the cytoplasm in a punctate pattern
highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein involved in phosphate transport
similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 also involved in vacuolar protein targeting peripheral vesicle membrane protein
similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W
similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W
highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity
similar to uniprot|P38374 Saccharomyces cerevisiae YBR162W-A YSY6 Protein that participates in secretory pathway
similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Target of SBF
similar to uniprot|P33300 Saccharomyces cerevisiae YPL057C SUR1 and similar to uniprot|P38287 Saccharomyces cerevisiae YBR161w CSH1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase forms a complex with probable regulatory subunit Csg2p
highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W microsomal beta-keto-reductase
some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function null mutant forms abnormally large cells
weakly similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability
some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Protein of unknown function
weakly similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
weakly similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Mitotic spindle protein involved in chromosome segregation.
similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 cyclophilin seven suppressor component of Hsp90p chaperone machinery
similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W KRE2 Alpha1 2-mannosyltransferase of the Golgi involved in protein mannosylation
similar to uniprot|P53386 Saccharomyces cerevisiae YPR192W AQY1 Water channel that mediates the transport of water across cell membranes and may be involved in freeze tolerance
similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C
some similarities with uniprot|Q751G8 Ashbya gossypii AGL262C AGL262Cp
some similarities with uniprot|Q06674 Saccharomyces cerevisiae YDR317W
similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C
highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3-epoxide a step in ergosterol biosynthesis
similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin-like protein
weakly similar to uniprot|Q12048 Saccharomyces cerevisiae YPL250C ICY2 Protein that interacts with the cytoskeleton and is involved in chromatin organization and nuclear transport
similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W
similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t-SNARES Sed5p and Pep12p
similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis
weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion
similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
some similarities with uniprot|P33757 Saccharomyces cerevisiae YBR250W
some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin-dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription
highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif
similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 High copy suppressor of choline-transport mutants
similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Suppressor of translation mutants Translation initiation factor eIF-4B
similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 The authentic non-tagged protein was localized to the mitochondria
uniprot|Q8J212 Kluyveromyces lactis RHO1_KLULA Protein Rho1
mitochondrial 37S ribosomal protein MRP2
highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit
weakly similar to uniprot|P32460 YIR030c Saccharomyces cerevisiae YIR030c DCG1 involved in nitrogen-catabolite metabolism
highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase reduces 3'-phosphoadenylyl sulfate to adenosine-3' 5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate involved in sulfate assimilation and methionine metabolism
similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription
similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Nucleolar protein of unknown function exhibits a physical interaction with Bre1p
highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B
some similarities with uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton
similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W
similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA-type ATPase
highly similar to uniprot|P49089 Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase isozyme of Asn2p catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C
some similarities with gnl|GLV|CAGL0D05016g Candida glabrata CAGL0D05016g and some similarities with YPR143W uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Essential protein involved in pre-rRNA processing
similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis localizes to the spindle pole body and localization is dependent on functional Cik1p required for nuclear fusion during mating potential Cdc28p substrate
similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W
similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66
weakly similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W
similar to uniprot|P53390 Saccharomyces cerevisiae YPR138C MEP3 Ammonium permease of high capacity and low affinity belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+) expression is under the nitrogen catabolite repression regulation ammonia permease or uniprot|P40260 Saccharomyces cerevisiae YGR121C MEP1
some similarities with uniprot|Q12218 Saccharomyces cerevisiae YOR009W YOROO9W TIR4 protein
similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA)
similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein required for sister chromatid cohesion interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
weakly similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
some similarities with uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Essential subunit of the nuclear pore complex (NPC)
weakly similar to uniprot|P08593 YPR134W Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p
similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C IWS1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II probable transcriptional elongation factor metazoan homologs contain an acidic N terminus mutations in the gene confer an Spt-phenotype
uniprot|Q875M3 Kluyveromyces lactis KLLA0B11231g RPS23
similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C
similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
some similarities with uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain may bind RNA and have a role in RNA processing overproduction suppresses a null mutation in CHC1 which encodes the heavy chain of clathrin
similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter involved in beta-oxidation of medium-chain fatty acid required for peroxisome proliferation
similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W
some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase
similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation
similar to uniprot|Q75EP9 Ashbya gossypii AAR030W AAR030Wp and some similarites with YPR124W uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High-affinity copper transporter of the plasma membrane mediates nearly all copper uptake under low copper conditions transcriptionally induced at low copper levels and degraded at high copper levels
some similarities with uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Component of the DASH complex localized to intranuclear spindles and spindle pole bodies interacts with Duo1p and Mps1p key Ipl1p target for regulating kinetochore-microtubule attachments
similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W
mitochondrial 37S ribosomal protein MRPS5
similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity
similar to gnl|GLV|CAGL0H09438g Candida glabrata CAGL0H09438g and weakly similar to YER016W uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Long chain fatty acyl-CoA synthetase accepts a wider range of acyl chain lengths than Faa1p preferring C9:0-C13:0 involved in the activation of endogenous pools of fatty acids
similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP involved in splicing binds the U2 snRNA stem-loop IV in vitro does not contain the conserved C-terminal RNA binding domain found in other family members
similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway converting protoporphyrinogen IX to protoporphyrin IX
similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family associates with the lariat intermediate before the second catalytic step of splicing
highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 20S proteasome beta-type subunit localizes to the nucleus throughout the cell cycle
highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair
similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W
similar to uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial Distribution and Morphology
weakly similar to uniprot|P40570 Saccharomyces cerevisiae YIR014W
similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends not shared between Rnase MRP and Rnase P in contrast to all other Rnase P protein subunits
some similarities with uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta-barrel proteins also proposed to be involved in mitochondrial import
highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 20S proteasome alpha-type subunit
weakly similar to uniprot|Q08206 Saccharomyces cerevisiae YOL036W Protein of unknown function potential Cdc28p substrate
weakly similar to uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex participates in the regulation of sulfur metabolism
uniprot|Q9P8P0 Kluyveromyces lactis MPK1 MAP kinase
similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting
similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene
similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W
similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2
similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W
similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C MRS5 Essential protein of the inner mitochondrial membrane peripherally localized component of the TIM22 complex which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
highly similar to uniprot|P11632 Saccharomyces cerevisiae YPR052C NHP6A High-mobility group non-histone chromatin protein functionally redundant with Nhp6Bp homologous to mammalian high mobility group proteins 1 and 2 acts to recruit transcription factor Rcs1p to certain promoters
highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA) functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
highly similar to uniprot|Q75B80 Ashbya gossypii ADL308C ADL308Cp and similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus
similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm- to-vacuole targeting pathway also required for peroxisomal degradation (pexophagy)
similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Protein with a potential role in DNA replication displays synthetic lethal genetic interaction with the pol3-13 allele of POL3 which encodes DNA polymerase delta
similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W
mitochondrial 54S ribosomal protein YmL47
highly similar to uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 clathrin Associated Protein complex Large subunit Large subunit of clathrin associated protein complex
highly similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Single-domain racemase possibly non-specific due to the lack of the second domain which presumably determines specificity
weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2
similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 Subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
weakly similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p) required for interpolar microtubules to provide an outward force on the spindle poles
similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A
similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II catalyzes the first step of the riboflavin biosynthesis pathway
similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis
similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria
weakly similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C
similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C
similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C
similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline-rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3
highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control
similar to uniprot|P36069 Saccharomyces cerevisiae YKL128C PMU1 Phospho MUtase homolog. Small region homologous to active site of phospho-mutases these move phosphates via a phospho-histidine intermediate. Homologs include: Sc GPM1 bact. Pgm Hs Bpgm & rat fructose-2 6-bisphosphatase Phospo-mutase homolog
similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
uniprot|Q6XCY9 Kluyveromyces lactis KU80 Ku80p
highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism
similar to uniprot|P12688 Saccharomyces cerevisiae YKL126W YPK1 and similar to uniprot|P18961 Saccharomyces cerevisiae YMR104C YPK2 serine/threonine protein kinase
some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor
similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions
similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane
similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family
similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis and weakly similar to YBR002C uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
weakly similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex
similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W
similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W
similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids involved in the activation of imported fatty acids not required for growth on nonfermentable carbon sources essential for stationary phase and similar to YMR246W uniprot|P47912 Saccharomyces cerevisiae YMR246W FAA4 Long chain fatty acyl-CoA synthetase and similar to YIL009W uniprot|P39002 Saccharomyces cerevisiae YIL009W FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
weakly similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'-end of a DNA strand
weakly similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W
similar to uniprot|Q05024 Saccharomyces cerevisiae YMR233W Interacts with Top1p in 2-hybrid assay
similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis mouse homolog shows altered expression in Huntington's disease model mice
some similarities with uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip required for the alignment of parental nuclei before nuclear fusion during mating
similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins also interacts with Pep7p
similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p and the high osmolarity response pathway via phosphorylation of Pbs2p regulated by Ste20p and Ste50p
similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Protein involved in cell cycle regulation
weakly similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 involved in vacuolar protein targeting
similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway
similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook
highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease integral membrane protein with 13 putative membrane-spanning regions also involved in cysteine uptake
highly similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs
highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p
highly similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism
similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis
mitochondrial 37S ribosomal protein YmS16
similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator
similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance
highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit
highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment
uniprot|O74232 Kluyveromyces lactis CAP1 CAPZA F-actin capping protein alpha subunit
similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
similar to uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p and similar to YHL003C uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p
mitochondrial 37S ribosomal protein MRP4
similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in recombination
highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus
similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
similar to uniprot|Q03497 Saccharomyces cerevisiae YHL007C STE20 Signal transducing kinase of the PAK (p21-activated kinase) family involved in pheromone response and pseudohyphal/invasive growth pathways activated by Cdc42p binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p
similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination
some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor
similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint
uniprot|P49379 Kluyveromyces lactis KLLA0B13761g CBF1 Centromere-binding protein 1
similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W
similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
weakly similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W
highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex
highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo
highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity
similar to uniprot|Q08975 Saccharomyces cerevisiae YPL258C THI21 Hydroxymethylpyrimidine phosphate kinase involved in the last steps in thiamine biosynthesis member of a gene family with THI20 and THI22 functionally redundant with Thi20p
highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg
similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function
similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein
similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA
similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N-hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis
highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C-terminal domain of Hyp2p (eIF5A) has four to five HEAT-like repeats
similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C
highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre-ribosomal particles
similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W
similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase) catalyzes the last two steps in phosphatidylcholine biosynthesis
similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells
highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme involved in ubiquitin-mediated protein degradation and essential for viability
similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p which is a Ran homolog of the Ras GTPase family and stimulates nucleotide release involved in nuclear protein import nucleotide release is inhibited by Yrb1p
similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele
similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM
highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme)
similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Lipid phosphoinositide phosphatase of the ER and Golgi involved in protein trafficking and secretion
similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin-mediated protein degradation forms complex with Cdc48p plays a role in controlling cellular ubiquitin concentration also promotes efficient NHEJ in postdiauxic/stationary phase
weakly similar to uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family when overexpressed can substitute for the function of Yra1p in export of poly(A) mRNA from the nucleus
highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Pic2p but more abundant than Pic2 under normal conditions
similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Flavohemoglobin may play a role in the oxidative stress response
uniprot|Q9HG12 Kluyveromyces lactis KLLA0B14553g HMRA1 Mating-type protein A1
uniprot|Q9HG13 Kluyveromyces lactis KLLA0B14575g HMRA2 Mating-type protein A2
some similarities with uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins
weakly similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease
similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism
weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions
weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and weakly similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
uniprot|P07921 Kluyveromyces lactis KLLA0B14861g LAC12 Lactose permease
uniprot|P00723 Kluyveromyces lactis KLLA0B14883g LAC4 Beta-galactosidase
some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p