Hepatitis GB virus B, complete genome.
type: Entry
definition: Hepatitis GB virus B, complete genome.
sequence version: NC_001655.1
sequence date: 2019-05-23
sequence: sequence
division: VRL
label: NC_001655.1
type: RefSeq
SIO_000068: refseq
dblink: PRJNA485481
keyword: RefSeq
source: GB virus-B
organism: GB virus-B
taxonomy: Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus; Hepacivirus platyrrhini.
reference: 1
references: 10502525
reference: 2
reference: 3
comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from AF179612.\nThe mature peptides were predicted and annotated by the NCBI staff\nby analogy with those of Hepatitis C virus.\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000353
sequence length: 9399
topology: linear
so has quality: SO_0000987
location: 1..9399
location: region:1-9399:1
RO_0002162: 2847087

NC_001655
type: RefSeq
SIO_000068: refseq

PRJNA485481
type: BioProject
SIO_000068: bioproject

1
title: Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agent
author: Bukh, J.
author: Apgar, C.L.
author: Yanagi, M.
journal: Virology
volume: 262
issue: 2
pages: 470-478
year: 1999
pubmed: 10502525

10502525
type: PubMed
SIO_000068: pubmed

2
title: Direct Submission
journal: Submitted (18-NOV-2003) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

3
title: Direct Submission
author: Bukh, J.
journal: Submitted (23-AUG-1999) Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 201, 7 Center Dr. 0740, Bethesda, MD 20892, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:9399:1
position: 9399
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-9399:1:source
so part of: sequence
organism: GB virus-B
mol type: genomic RNA

2847087
type: Taxonomy
SIO_000068: taxonomy

HGvBgp1
type: Gene
subclass of: SO_0000704
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
so part of: sequence
location: 446..9040
location: region:446-9040:1
so has part: feature:446-9040:1:exon
subclass of: SO_0000010

1403460
type: Gene
SIO_000068: ncbigene

position:446:1
position: 446
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:9040:1
position: 9040
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:446-9040:1:exon

HGvBgp1
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
note: Cleavage sites were added by NCBI staff based on homology to other hepaciviruses and these sources: PMID: 25926652, PMID: 26038514, PMID: 23572554, PMID: 16492760
codon start: 1
product: polyprotein
translation: MPVISTQTSPVPAPRTRKNKQTQASYPVSIKTSVERGQRAKRKVQRDARPRNYKIAGIHDGLQTLAQAALPAHGWGRQDPRHKSRNLGILLDYPLGWIGDVTTHTPLVGPLVAGAVVRPVCQIVRLLEDGVNWATGWFGVHLFVVCLLSLACPCSGARVTDPDTNTTILTNCCQRNQVIYCSPSTCLHEPGCVICADECWVPANPYISHPSNWTGTDSFLADHIDFVMGALVTCDALDIGELCGACVLVGDWLVRHWLIHIDLNETGTCYLEVPTGIDPGFLGFIGWMAGKVEAVIFLTKLASQVPYAIATMFSSVHYLAVGALIYYASRGKWYQLLLALMLYIEATSGNPIRVPTGCSIAEFCSPLMIPCPCHSYLSENVSEVICYSPKWTRPITLEYNNSISWYPYTIPGARGCMVKFKNNTWGCCRIRNVPSYCTMGTDAVWNDTRNTYEACGVTPWLTTAWHNGSALKLAILQYPGSKEMFKPHNWMSGHLYFEGSDTPIVYFYDPVNSTLLPPERWARLPGTPPVVRGSWLQVPQGFYSDVKDLATGLITKDKAWKNYQVLYSATGALSLTGVTTKAVVLILLGLCGSKYLILAYLCYLSLCFGRASGYPLRPVLPSQSYLQAGWDVLSKAQVAPFALIFFICCYLRCRLRYAALLGFVPMAAGLPLTFFVAAAAAQPDYDWWVRLLVAGLVLWAGRNRGHRIALLVGPWPLVALLTLLHLVTPASAFDTEIIGGLTIPPVVALVVMSRFGFFAHLLPRCALVNSYLWQRWENWFWNVTLRPERFFLVLVCFPGATYDALVTFCVCHVALLCLTSSAASFFGTDSRVRAHRMLVRLGKCHAWYSHYVLKFFLLVFGENGVFFYKHLHGDVLPNDFASKLPLQEPFFPFEGKARVYRNEGRRLACGDTVDGLPVVARLGDLVFAGLAMPPDGWAITAPFTLQCLSERGTLSAMAVVMTGIDPRTWTGTIFRLGSLATSYMGFVCDNVLYTAHHGSKGRRLAHPTGSIHPITVDAANDQDIYQPPCGAGSLTRCSCGETKGYLVTRLGSLVEVNKSDDPYWCVCGALPMAVAKGSSGAPILCSSGHVIGMFTAARNSGGSVSQIRVRPLVCAGYHPQYTAHATLDTKPTVPNEYSVQILIAPTGSGKSTKLPLSYMQEKYEVLVLNPSVATTASMPKYMHATYGVNPNCYFNGKCTNTGASLTYSTYGMYLTGACSRNYDVIICDECHATDATTVLGIGKVLTEAPSKNVRLVVLATATPPGVIPTPHANITEIQLTDEGTIPFHGKKIKEENLKKGRHLIFEATKKHCDELANELARKGITAVSYYRGCDISKIPEGDCVVVATDALCTGYTGDFDSVYDCSLMVEGTCHVDLDPTFTMGVRVCGVSAIVKGQRRGRTGRGRAGIYYYVDGSCTPSGMVPECNIVEAFDAAKAWYGLSSTEAQTILDTYRTQPGLPAIGANLDEWADLFSMVNPEPSFVNTAKRTADNYVLLTAAQLQLCHQYGYAAPNDAPRWQGARLGKKPCGVLWRLDGADACPGPEPSEVTRYQMCFTEVNTSGTAALAVGVGVAMAYLAIDTFGATCVRRCWSITSVPTGATVAPVVDEEEIVEECASFIPLEAMVAAIDKLKSTITTTSPFTLETALEKLNTFLGPHAATILAIIEYCCGLVTLPDNPFASCVFAFIAGITTPLPHKIKMFLSLFGGAIASKLTDARGALAFMMAGAAGTALGTWTSVGFVFDMLGGYAAASSTACLTFKCLMGEWPTMDQLAGLVYSAFNPAAGVVGVLSACAMFALTTAGPDHWPNRLLTMLARSNTVCNEYFIATRDIRRKILGILEASTPWSVISACIRWLHTPTEDDCGLIAWGLEIWQYVCNFFVICFNVLKAGVQSMVNIPGCPFYSCQKGYKGPWIGSGMLQARCPCGAELIFSVENGFAKLYKGPRTCSNYWRGAVPVNARLCGSARPDPTDWTSLVVNYGVRDYCKYEKMGDHIFVTAVS…
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 446..9040
location: region:446-9040:1
so has part: feature:446-9040:1:exon

NP_056931.1
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:446-9040:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: core protein C
inference: non-experimental evidence, no additional details recorded
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 446..913
location: region:446-913:1
so has part: feature:446-913:1:exon

NP_757352.1
type: Protein
SIO_000068: ncbiprotein

position:913:1
position: 913
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:446-913:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: envelope protein E1
inference: non-experimental evidence, no additional details recorded
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 914..1492
location: region:914-1492:1
so has part: feature:914-1492:1:exon

NP_757353.1
type: Protein
SIO_000068: ncbiprotein

position:914:1
position: 914
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1492:1
position: 1492
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:914-1492:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: envelope protein E2
inference: non-experimental evidence, no additional details recorded
note: NS1
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 1493..2284
location: region:1493-2284:1
so has part: feature:1493-2284:1:exon

NP_757354.1
type: Protein
SIO_000068: ncbiprotein

position:1493:1
position: 1493
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2284:1
position: 2284
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1493-2284:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: protein p13
experiment: COORDINATES:[16492760]
note: E2/p13 and p13/NS2 cleavage sites annotated according to experimental evidence reported in PMID: 16492760
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 2285..2641
location: region:2285-2641:1
so has part: feature:2285-2641:1:exon

position:2285:1
position: 2285
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2641:1
position: 2641
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2285-2641:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: protein p6
experiment: COORDINATES:[16492760]
note: E2/p6 and p6/p7 cleavage sites annotated according to experimental evidence reported in PMID: 16492760, which also reported that p6 may not be necessary in vivo
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 2285..2455
location: region:2285-2455:1
so has part: feature:2285-2455:1:exon

position:2455:1
position: 2455
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2285-2455:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: protein p7
experiment: COORDINATES:[16492760]
inference: non-experimental evidence, no additional details recorded
note: p6/p7 and p7/NS2 cleavage sites annotated according to experimental evidence reported in PMID: 16492760. There was some evidence the protein may also be cleaved at amino acid 681/682 (genomic position 2488/2489)
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 2456..2641
location: region:2456-2641:1
so has part: feature:2456-2641:1:exon

NP_757355.1
type: Protein
SIO_000068: ncbiprotein

position:2456:1
position: 2456
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2456-2641:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: nonstructural protein NS2
inference: non-experimental evidence, no additional details recorded
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 2642..3265
location: region:2642-3265:1
so has part: feature:2642-3265:1:exon

NP_757356.1
type: Protein
SIO_000068: ncbiprotein

position:2642:1
position: 2642
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:3265:1
position: 3265
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2642-3265:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: nonstructural protein NS3
inference: non-experimental evidence, no additional details recorded
note: NS3 serine protease/NS3P/ATPase/helicase peptide/hepacivirin
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 3266..5125
location: region:3266-5125:1
so has part: feature:3266-5125:1:exon

NP_757357.1
type: Protein
SIO_000068: ncbiprotein

position:3266:1
position: 3266
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5125:1
position: 5125
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3266-5125:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: nonstructural protein NS4A
inference: non-experimental evidence, no additional details recorded
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 5126..5290
location: region:5126-5290:1
so has part: feature:5126-5290:1:exon

NP_757358.1
type: Protein
SIO_000068: ncbiprotein

position:5126:1
position: 5126
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5290:1
position: 5290
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5126-5290:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: nonstructural protein NS4B
inference: non-experimental evidence, no additional details recorded
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 5291..6034
location: region:5291-6034:1
so has part: feature:5291-6034:1:exon

NP_757359.1
type: Protein
SIO_000068: ncbiprotein

position:5291:1
position: 5291
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6034:1
position: 6034
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5291-6034:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: nonstructural protein NS5A
inference: non-experimental evidence, no additional details recorded
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 6035..7267
location: region:6035-7267:1
so has part: feature:6035-7267:1:exon

NP_757360.1
type: Protein
SIO_000068: ncbiprotein

position:6035:1
position: 6035
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7267:1
position: 7267
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6035-7267:1:exon

HGvBgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 2847087
gene: POLY
locus tag: HGvBgp1
product: nonstructural protein NS5B
inference: non-experimental evidence, no additional details recorded
note: NS5B RNA-dependent RNA polymerase peptide; RdRp
SIO_010081: HGvBgp1
subclass of: SO_0000673
so part of: HGvBgp1
location: 7268..9037
location: region:7268-9037:1
so has part: feature:7268-9037:1:exon

NP_757361.1
type: Protein
SIO_000068: ncbiprotein

position:7268:1
position: 7268
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:9037:1
position: 9037
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7268-9037:1:exon