Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Severe acute respiratory syndrome coronavirus 2
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus.
A new coronavirus associated with human respiratory disease in China
Programmed ribosomal frameshifting in decoding the SARS-CoV genome
The structure of a rigorously conserved RNA element within the SARS virus genome
A phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication
Submitted (17-JAN-2020) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (05-JAN-2020) Shanghai Public Health Clinical Center & School of Public Health, Fudan University, Shanghai, China
REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence is identical to MN908947.\nOn Jan 17, 2020 this sequence version replaced NC_045512.1.\nAnnotation was added using homology to SARSr-CoV NC_004718.3. ###\nFormerly called 'Wuhan seafood market pneumonia virus.' If you have\nquestions or suggestions, please email us at info@ncbi.nlm.nih.gov\nand include the accession number NC_045512.### Protein structures\ncan be found at\nhttps://www.ncbi.nlm.nih.gov/structure/?term=sars-cov-2.### Find\nall other Severe acute respiratory syndrome coronavirus 2\n(SARS-CoV-2) sequences at\nhttps://www.ncbi.nlm.nih.gov/genbank/sars-cov-2-seqs/\n\n##Assembly-Data-START##\nAssembly Method :: Megahit v. V1.1.3\nSequencing Technology :: Illumina\n##Assembly-Data-END##\nCOMPLETENESS: full length.
pp1ab; translated by -1 ribosomal frameshift
former nsp1; conserved domains are: N-terminal acidic (Ac), predicted phosphoesterase, papain-like proteinase, Y-domain, transmembrane domain 1 (TM1), adenosine diphosphate-ribose 1''-phosphatase (ADRP); produced by both pp1a and pp1ab
nsp4B_TM; contains transmembrane domain 2 (TM2); produced by both pp1a and pp1ab
nsp5A_3CLpro and nsp5B_3CLpro; main proteinase (Mpro); mediates cleavages downstream of nsp4. 3D structure of the SARSr-CoV homolog has been determined (Yang et al., 2003); produced by both pp1a and pp1ab
nsp6_TM; putative transmembrane domain; produced by both pp1a and pp1ab
ssRNA-binding protein; produced by both pp1a and pp1ab
nsp10_CysHis; formerly known as growth-factor-like protein (GFL); produced by both pp1a and pp1ab
nsp12; NiRAN and RdRp; produced by pp1ab only
nsp13_ZBD, nsp13_TB, and nsp_HEL1core; zinc-binding domain (ZD), NTPase/helicase domain (HEL), RNA 5'-triphosphatase; produced by pp1ab only
nsp14A2_ExoN and nsp14B_NMT; produced by pp1ab only
nsp15-A1 and nsp15B-NendoU; produced by pp1ab only
nsp16_OMT; 2'-o-MT; produced by pp1ab only
COORDINATES: profile:Rfam-release-14.1:RF00507,Infernal:1.1.2
Coronavirus frameshifting stimulation element stem-loop 1
Coronavirus frameshifting stimulation element stem-loop 2
COORDINATES: profile::Rfam-release-14.1:RF00165,Infernal:1.1.2
Coronavirus 3' UTR pseudoknot stem-loop 1
Coronavirus 3' UTR pseudoknot stem-loop 2
COORDINATES: profile:Rfam-release-14.1:RF00164,Infernal:1.1.2
basepair exception: alignment to the Rfam model implies coordinates 29740:29758 form a noncanonical C:T basepair, but the homologous positions form a highly conserved C:G basepair in other viruses, including SARS (NC_004718.3)
Coronavirus 3' stem-loop II-like motif (s2m)