Candida albicans SC5314 chromosome 7, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure
Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes
The diploid genome sequence of Candida albicans
Submitted (15-APR-2022) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (04-OCT-2016) Department of Genetics, Candida Genome Database, Stanford University, Mail Stop-5120, Stanford, CA 94305, USA
Submitted (30-SEP-2016) Department of Genetics, Candida Genome Database, Stanford University, Mail Stop-5120, Stanford, CA 94305, USA
Sequence and annotation update by submitter
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP017629.\n\n##Genome-Assembly-Data-START##\nAssembly Method :: Bowtie v. 1.0\nAssembly Name :: C_albicans_SC5314_A22\nLong Assembly Name :: Candida albicans SC5314 Assembly 22\nGenome Coverage :: 700x\nSequencing Technology :: Illumina GAIIx\n##Genome-Assembly-Data-END##\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: CGD\nAnnotation Status :: Full annotation\nAnnotation Version :: A22-s07-m01-r01\nURL :: http://www.candidagenome.org/\n##Genome-Annotation-Data-END##
Protein of unknown function; Spider biofilm repressed
Protein required for endocytosis; contains a BAR domain, which is found in proteins involved in membrane curvature; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization
TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit
Ortholog of S. cerevisiae Rad3; 5' to 3' DNA helicase, nucleotide excision repair and transcription, subunit of RNA polII initiation factor TFIIH and Nucleotide Excision Repair Factor 3 (NEF3)
Ortholog(s) have adenylate kinase activity, nucleoside triphosphate adenylate kinase activity, role in nucleotide metabolic process and mitochondrial inner membrane, mitochondrial matrix localization
Protein of unknown function; transcript induced in RHE model of oral candidiasis; Spider biofilm repressed
Putative GTPase activating protein (GAP) for Rho1; repressed upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcript is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis
Surface antigen on elongating hyphae and buds; strain variation in repeat number; ciclopirox, filament induced, alkaline induced by Rim101; Efg1-, Cph1, Hap43-regulated; required for WT RPMI biofilm formation; Bcr1-induced in a/a biofilms
Putative ferric reductase; alkaline induced by Rim101; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced; regulated by Sef1, Sfu1, and Hap43
Cytosolic manganese-containing superoxide dismutase; protects against oxidative stress; repressed by ciclopirox olamine, induced during stationary phase when SOD1 expression is low; Hap43-repressed; Spider and flow model biofilm induced
Putative mitochondrial outer membrane protein membrane fission effector; possibly an essential gene, disruptants not obtained by UAU1 method
Ortholog(s) have tRNA-specific adenosine-37 deaminase activity, role in tRNA modification and cytosol, nucleus localization
Ortholog(s) have cytosol, nucleus localization
D-ribulose-5-phosphate 3-epimerase; stationary phase enriched protein
Ortholog(s) have role in ribosomal large subunit biogenesis and cytoplasm, nucleus, ribosome localization
Ortholog(s) have role in protein targeting to vacuole and endoplasmic reticulum localization
cyclin-dependent protein serine/threonine kinase inhibiting protein
Protein involved in regulation of pheromone-mediated mating; repressed by A1p and Alpha2p in white-phase cells; null mutant shows no pheromone response in opaque cells; overexpression causes enhanced pheromone response and cell cycle arrest
Adhesin-like cell wall protein; similar to mucins and to a Litomosoides microfilarial sheath protein; N-terminal secretion signal; rat catheter and Spider biofilm repressed
Predicted exonuclease; Spider biofilm induced
Ortholog(s) have telomeric DNA binding activity, role in protein localization to chromosome, telomere maintenance via telomerase and ASTRA complex, nuclear chromosome, telomeric region localization
Has domain(s) with predicted exonuclease activity and intracellular localization
Putative vacuolar transporter of large neutral amino acids; possibly transcriptionally regulated upon hyphal formation; not the true Avt1 ortholog of S. cerevisiae
Putative protein of unknown function; Hap43-repressed; repressed by nitric oxide; Spider biofilm induced
Putative cytoplasmic RNA-binding protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in C. albicans fitness test; Spider biofilm repressed
Ortholog(s) have fungal-type vacuole membrane, mitochondrion localization
Ortholog(s) have fluoride transmembrane transporter activity, role in fluoride transmembrane transport and endoplasmic reticulum, plasma membrane localization
Glucose, fructose, mannose transporter; major facilitator superfamily; role in macrophage-induced hyphal growth; detected at germ tube plasma membrane by mass spectrometry; Snf3p-induced; 12 probable transmembrane segments
Predicted sugar transporter, involved in glycerol utilization; member of the major facilitator superfamily; 12 transmembrane; gene has intron; oxidative stress-induced via Cap1p; expressed in rich medium, 2% glucose
Putative NAD dependent epimerase/dehydratase family protein; Spider biofilm repressed
Protein of unknown function; induced by nitric oxide; Spider biofilm repressed
Ca(2+)/Mn(2+)-transporting P-type ATPase
Putative secretory pathway P-type Ca2+/Mn2+-ATPase; required for protein glycosylation and cell wall maintenance; required for hyphal tip oscillation in semisolid substrate; putative ortholog of S. cerevisiae PMR1
Ortholog(s) have single-stranded telomeric DNA binding activity, role in regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification, telomere maintenance and cytosol, nucleus localization
Ortholog(s) have protein transporter activity, role in transcription factor import into nucleus and cytosol, nuclear envelope localization
Protein of unknown function; induced in core stress response; induced by cadmium stress via Hog1; oxidative stress-induced via Cap1; induced by Mnl1 under weak acid stress; macrophage-repressed; rat catheter and Spider biofilm induced
Cell-surface associated glycoprotein; promotes activation of Cek1 in a matrix-dependent manner; N-glycosylated; Spider biofilm induced
Protein with a predicted role in sister chromatid cohesion and telomere length maintenance; cell-cycle regulated periodic mRNA expression
S-adenosylmethionine transporter of the mitochondrial inner membrane; mitochondrial carrier family; predicted role in biotin biosynthesis and respiratory growth; Spider biofilm repressed
Protein similar to S. cerevisiae Spl1p, which is involved in tRNA splicing; member of pyridoxal-phosphate-dependent aminotransferase protein family; predicted to be essential
Isopropyl malate dehydrogenase; leucine biosynthesis; induced by human whole blood or PMNs; protein level decreases in stationary phase; GlcNAc-induced protein; flow model biofilm repressed
Ortholog(s) have Rho guanyl-nucleotide exchange factor activity, role in axial cellular bud site selection, cytogamy, positive regulation of GTPase activity and cellular bud neck contractile ring localization
Putative ferric reductase; induced by Mac1 under copper starvation; Plc1-regulated; Rim101-repressed
single-stranded telomeric DNA-binding/mRNA-binding protein
Putative single-strand telomeric DNA-binding protein; protein level decreases in stationary phase cultures; Spider biofilm repressed
Ortholog(s) have methylated histone binding, transcription factor activity, RNA polymerase II transcription factor recruiting activity
Ortholog of S. cerevisiae : YCL002C, C. glabrata CBS138 : CAGL0B04719g, C. dubliniensis CD36 : Cd36_70180, C. parapsilosis CDC317 : CPAR2_805360 and Candida tenuis NRRL Y-1498 : cten_CGOB_00114
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Predicted enzyme of mitochondrial phospholipid biosynthesis; rat catheter and flow model biofilm induced
Protein similar to phosphate transporters; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching
Putative AdoMet-dependent proline methyltransferase; Hap43-induced; required for normal flow model biofilm growth; Spider biofilm repressed
Ortholog of Candida guilliermondii ATCC 6260 : PGUG_03499, Candida lusitaniae ATCC 42720 : CLUG_00410 and Candida albicans WO-1 : CAWG_05407
Copper fist transcription factor; regulator of CTR1 copper transporter; induces CTR1 in low-copper conditions; required for copper regulation of SOD1 and SOD3; Spider biofilm induced
Ortholog(s) have RNA polymerase II C-terminal domain phosphoserine binding, RNA polymerase II core binding, transcription factor activity, RNA polymerase II transcription factor binding, triplex DNA binding activity
Putative GINS complex subunit; cell-cycle regulated periodic mRNA expression; Spider biofilm induced
(snR46a) H/ACA box small nucleolar RNA (snoRNA)
Putative tRNA-Gln synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures
tRNA guanylyltransferase, with role in tRNA modification; catalyzes reverse (3'-5') nucleotide polymerization
DNA-directed RNA polymerase I core subunit
Putative RNA polymerase I subunit A135; repressed by prostaglandins
Ortholog(s) have ATPase activity and cytosol, nucleus localization
Ortholog of C. dubliniensis CD36 : Cd36_70070, C. parapsilosis CDC317 : CPAR2_301080, Debaryomyces hansenii CBS767 : DEHA2F22946g and Pichia stipitis Pignal : PICST_46820
Ortholog(s) have endoribonuclease activity, role in nuclear mRNA surveillance of mRNP export, transcription, DNA-templated and cytoplasm, nucleus localization
Ortholog(s) have cytoplasm, nucleus localization
Putative glutamine-tRNA ligase; stationary phase enriched protein; Spider biofilm repressed
Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; regulated by Sef1, Sfu1, and Hap43
Putative regulatory subunit of ser/thr phosphoprotein phosphatase 1; fluconazole-induced; caspofungin repressed; transcript induced by Mnl1 under weak acid stress; regulated by Nrg1, Tup1; Spider and flow model biofilm induced
phosphatidylinositol-3-/phosphoinositide 5-phosphatase
Putative polyphosphatidylinositol phosphatase; possibly an essential gene, disruptants not obtained by UAU1 method
Maf-like protein; rat catheter biofilm induced
rRNA-binding ribosome biosynthesis protein
Nucleolar ribosome biogenesis factor; hyphal-induced expression; Hap43-induced; rat catheter biofilm induced
Cytochrome b(5); ortholog of S. cerevisiae Cyb5; induced in high iron; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6; mutants are viable
Putative RNA polymerase II-associated Paf1 complex subunit; induced during the mating process
Predicted bZIP domain-containing transcription factor; protein induced during the mating process; possibly essential, disruptants not obtained by UAU1 method; Hap43-repressed; rat catheter biofilm induced
Ortholog(s) have protein kinase activity
Protein similar to a region of acyl-coenzyme-A-binding protein; amphotericin B repressed; regulated by Nrg1, Tup1; Hap43-induced
Ortholog(s) have endoplasmic reticulum localization
Protein of unknown function; induced by benomyl or in an azole-resistant strain overexpressing MDR1; induced by nitric oxide; Spider biofilm induced
Putative pre-tRNA processing protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in membrane tubulation, protein targeting to vacuole, retrograde transport, endosome to Golgi and endosome, nucleus localization
Ortholog(s) have role in ribosomal large subunit biogenesis, translational initiation and cytoplasm, nucleus localization
Ortholog(s) have phosphatase activator activity, role in actin filament organization, endocytosis, mitophagy, regulation of growth, response to heat, response to salt stress and cytosol, nucleus localization
Putative heteropentameric replication factor C subunit; periodic mRNA expression, peak at cell-cycle G1/S phase
Putative eIF4E-associated protein;, accelerates mRNA degradation by promoting decapping; Spider biofilm repressed
tyrosine/serine/threonine protein phosphatase
Putative dual specificity protein phosphatase, similar to S. cerevisiae Pps1p
Ortholog of C. dubliniensis CD36 : Cd36_70790, C. parapsilosis CDC317 : CPAR2_301530, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94947 and Debaryomyces hansenii CBS767 : DEHA2A05258g
Beta-glucan associated ser/thr rich cell-wall protein with a role in cell wall structure; GPI anchor; similar mRNA abundance in yeast-form and germ tubes; detected at germ tube plasma membrane; repressed in cells treated with Congo Red
Putative guanine deaminase; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced
Protein of unknown function; Spider biofilm induced
Transcription factor; regulator of hyphal growth; may act with Wor1p; canonical and non-canonical binding sites; MADS domain DNA-binding motif; similar to S. cerevisiae Mcm1p; greater expression in white than opaque cells; intron in 5'-UTR
Ortholog of S. cerevisiae Ioc4, a protein that influences gene expression through chromatin remodeling; oxidative stress-induced via Cap1
Ortholog of C. dubliniensis CD36 : Cd36_70850, Candida tenuis NRRL Y-1498 : cten_CGOB_00183, Debaryomyces hansenii CBS767 : DEHA2F22462g and Pichia stipitis Pignal : PICST_60416
Putative glycogen phosphorylase; role in glycogen metabolism; regulated by Ssk1, Mig1, Tup1, Hap43; fluconazole-induced; localizes to cell surface of hyphae, not yeast; stationary phase enriched protein; Spider biofilm induced
Protein similar to S. cerevisiae Kex1p, which is a pheromone-processing peptidase; possible Kex2p substrate
mitochondrial 54S ribosomal protein YmL6
Putative mitochondrial ribosomal protein; induced upon adherence to polystyrene
Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; repressed by nitric oxide; Hap43-induced; Spider biofilm repressed
Putative homeodomain-containing transcription factor; transcriptional repressor; periodic mRNA expression, peak at cell-cycle G1/S phase
Ortholog(s) have endopolyphosphatase activity, exopolyphosphatase activity, role in polyphosphate catabolic process and cytosol, fungal-type vacuole membrane, nucleus localization
Putative ribosomal protein; antigenic in mouse; repressed upon phagocytosis by murine macrophage; induced by Tbf1; overlaps orf19.7014; Spider biofilm repressed
Putative protein of unknown function; transcription is positively regulated by Tbf1p; overlaps orf19.7015
Ortholog of C. dubliniensis CD36 : Cd36_70940, C. parapsilosis CDC317 : CPAR2_300280, Debaryomyces hansenii CBS767 : DEHA2F22220g and Pichia stipitis Pignal : PICST_32459
mitochondrial 37S ribosomal protein MRPS16
Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization
Ortholog(s) have mRNA binding activity and 90S preribosome, cytoplasm, mitotic spindle pole body, nucleolus localization
Ortholog(s) have cytosol, ubiquitin ligase complex localization
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process
Ortholog of C. dubliniensis CD36 : Cd36_70990 and Candida albicans WO-1 : CAWG_05464
Ortholog(s) have role in reciprocal meiotic recombination
(MRS-7a) Major Repeat Sequence (MRS) on Chromosome 7; MRS units are composed of variable numbers of RPS units flanked by HOK and RB2 sequences; found on most chromosomes; may serve as recombination hot spot
(RB2-7a) Repeat sequence of about 6 kb, part of the Major Repeat Sequence (MRS) on Chromosome 7; MRS units are found on most chromosomes; may serve as recombination hotspots
Predicted ORF overlapping the Major Repeat Sequence on chromosome 7; member of a family encoded by FGR6-related genes in the RB2 repeat sequence
(RPS-7a) Repeat sequence of about 2 kb on Chromosome 7, about 60 copies are found in tandem repeats on most chromosomes; RPS units flanked by conserved HOK and RB2 sequences form Major Repeat Sequence (MRS); may serve as recombination hot spot
(HOK-7a) Repeat sequence of about 8 kb, part of the Major Repeat Sequence (MRS) on Chromosome 7; MRS units are found on most chromosomes; may serve as recombination hotspots
(Ca3-7b) Ca3 region on Chromosome 7; Ca3 is a large dispersed repeat sequence utilized as species-specific and strain-specific RFLP probe
Protein similar to S. pombe SPBC1709.16c a predicted aromatic ring-opening dioxygenase; induced by benomyl treatment or in azole-resistant strain that overexpresses MDR1; Spider biofilm induced
Ortholog(s) have mitochondrion localization
Putative oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; rat catheter and Spider biofilm induced
Ortholog(s) have role in establishment or maintenance of cell polarity, mitochondrial outer membrane translocase complex assembly, mitochondrion inheritance, mitochondrion-ER tethering, phospholipid transport
5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
Ortholog(s) have RNA 7-methylguanosine cap binding, exoribonuclease activator activity, m7G(5')pppN diphosphatase activity
Putative ATP-dependent DEAD-box RNA helicase; Hap43-induced; rat catheter biofilm induced
Predicted RNA polymerase III subunit C37; Spider biofilm induced
translation initiation factor eIF2B subunit alpha
Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
Ortholog of S. cerevisiae : YNL011C, C. glabrata CBS138 : CAGL0H03619g, C. dubliniensis CD36 : Cd36_71090, C. parapsilosis CDC317 : CPAR2_300420 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_111980
(theta-7a) Long terminal repeat (LTR); about 366 bp long, 7 copies per genome
guanine nucleotide-binding protein subunit beta
40S ribosomal subunit similar to G-beta subunits; glucose or N starvation induced filamentation; required for virulence in mice; snoRNA snR24 encoded in ASC1 intron; repressed in stationary phase; GlcNAc-induced; Spider biofilm repressed
(snR24) C/D box small nucleolar RNA (snoRNA); snR24 is encoded within the intron of orf19.6906/ASC1
Ortholog(s) have DNA binding activity, role in regulation of DNA damage checkpoint and cytoplasm, nuclear chromatin, nuclear periphery localization
Dihydrofolate synthetase involved in folic acid biosynthesis
Subunit of the RNA polymerase II mediator complex
Putative GINS complex subunit which is localized to DNA replication origins; implicated in assembly of the DNA replication machinery; flow model biofilm induced
Translation initiation factor 2-alpha (eIF2alpha) kinase; has nonessential role in amino acid starvation response, in contrast to S. cerevisiae homolog; similar to S. cerevisiae Gcn2p
Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance
Ortholog(s) have unfolded protein binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrion localization
Putative heat shock protein with a zinc finger motif; required for protein import into mitochondria in S. cerevisiae; Spider biofilm induced
Protein of unknown function; Hap43-induced gene; Spider biofilm induced
Ortholog of C. dubliniensis CD36 : Cd36_71210, C. parapsilosis CDC317 : CPAR2_702710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116256 and Debaryomyces hansenii CBS767 : DEHA2E17732g
Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hap43-induced gene; Spider biofilm induced; F-12/CO2 early biofilm induced
Ortholog(s) have transcription factor activity, RNA polymerase I upstream control element sequence-specific binding activity and role in chromatin organization, transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Protein containing an SH3 domain; involved in vacuolar fusion in hyphae; mutants form multiple germ tubes; Spider biofilm induced
Ortholog of S. cerevisiae Gir2; transposon mutation affects filamentous growth
Protein of unknown function; transcript induced by benomyl or in azole-resistant strain overexpressing MDR1; Ssn6 colony morphology-related regulation; induced by NO; Hap43-repressed; rat catheter and flow model biofilm induced
translation initiation factor eIF3 subunit b
Putative translation initiation factor eIF3; mutation confers hypersensitivity to roridin A, verrucarin A; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophages
Protein of unknown function; induced by alpha pheromone in SpiderM medium
proteasome core particle subunit alpha 7
Alpha7 (C8) subunit of the 20S proteasome; multiple phosphorylated residues; transcript induced upon filamentous growth; Spider biofilm repressed
Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation and endoplasmic reticulum localization
Ortholog of C. dubliniensis CD36 : Cd36_71340, C. parapsilosis CDC317 : CPAR2_301350, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114098 and Debaryomyces hansenii CBS767 : DEHA2D03432g
Predicted membrane transporter; vesicular neurotransmitter (VNT) family, major facilitator superfamily (MFS); repressed in core caspofungin response; induced in oralpharyngeal candidasis; Spider biofilm induced
Multidrug efflux pump of the plasma membrane; MDR family member of the MFS (major facilitator superfamily) of transporters; involved in histatin 5 efflux; fungal-specific (no human/murine homolog)
Putative cytochrome P-450 of N-alkane-induced detoxification; macrophage-induced gene
Putative Rho1p GTPase activating protein (GAP); serum-induced transcript; Spider biofilm induced; flow model biofilm repressed
Nucleoside permease; adenosine and guanosine are substrates, whereas cytidine, adenine, guanine, uridine, uracil are not; similar to a nucleoside permease of S. pombe; possibly processed by Kex2p
Predicted transmembrane transporter; induced during chlamydospore formation in both C. albicans and C. dubliniensis
Putative structural maintenance of chromosomes (SMC) protein; Hap43-induced; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog not cell-cycle regulated; Spider biofilm induced
Ortholog of C. dubliniensis CD36 : Cd36_71420, C. parapsilosis CDC317 : CPAR2_300980, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94952 and Debaryomyces hansenii CBS767 : DEHA2A05346g
Conserved mitochondrial inner membrane insertase; mediates insertion of mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; Spider biofilm repressed
Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly, negative regulation of mitochondrial translation and integral component of mitochondrial inner membrane localization
Ortholog of Kch1 a potassium transporter; mediates K+ influx and activates high-affinity Ca2+ influx system during mating pheromone response in S. cerevisiae; induced by alpha pheromone in SpiderM medium
Putative ribonuclease H2 catalytic subunit; flucytosine induced; Spider biofilm repressed
dihydrolipoyllysine-residue acetyltransferase
Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex; sumoylation target; Spider biofilm repressed
RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; growth phase regulated protein; downregulaated in stationary phase yeast cultures; Hap43-repressed; flow model biofilm induced; Spider biofilm repressed
Ortholog(s) have GTPase activator activity and cytosol localization
Protein with a predicted fatty acid amide hydrolase I domain; induced by Mnl1 under weak acid stress
Protein of unknown function; rat catheter, flow model and Spider biofilm induced
Ortholog(s) have zinc ion binding activity, role in protein import into mitochondrial intermembrane space and cytosol, mitochondrial intermembrane space, nucleus localization
Regulator of calcineurin; regulated by calcineurin-Crz1 pathway; feedback regulator of calcineurin-dependent signaling; Hap43-repressed; induced by ketoconazole, hypoxia, during growth in the mouse cecum; Spider biofilm induced
Membrane-localized protein of unknown function; possibly secreted; fluconazole-induced
Flavin-linked sulfhydryl oxidase; predicted localization to endoplasmic reticulum lumen; involved in disulfide bond formation within the ER; Spider biofilm induced
Protein similar to S. cerevisiae Ste18p; expressed in opaque or white MTLa/MTLa or MTLalpha/MTLalpha, but not MTLa/MTLalpha cells; MTLa1p, MTLalpha2p bind promoter region
Ortholog(s) have SNAP receptor activity, role in Golgi vesicle transport, vesicle fusion and Golgi medial cisterna, SNARE complex localization
Putative mitochondrial outer membrane protein; regulated by Sef1p-, Sfu1p-, and Hap43p
Protein with similarity to NifU; possible role in iron-sulfur cluster biogenesis; induced in low iron; rat catheter biofilm induced; rat catheter and Spider biofilm induced
Protein phosphatase type 1 regulator; role in chromosome segregation, regulation of phosphoprotein phosphatase activity; rat catheter and Spider biofilm induced
Ribosomal protein; repressed upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed
Phosphofructokinase beta subunit; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced; rat catheter/Spider biofilm repressed
RuvB family ATP-dependent DNA helicase reptin
Putative trancription modulator; RuvB-like protein family member; heterozygous null mutant displays sensitivity to virgineone
H(+)-transporting V0 sector ATPase subunit c'
Predicted ortholog of S. cerevisiae Tfp3/Vma11; c' subunit of the V0 subcomplex of the vacuolar ATPase; required for hemoglobin-iron utilization; Spider biofilm repressed
Ortholog(s) have role in chromosome segregation and nuclear MIS12/MIND complex, spindle pole localization
Actomyosin ring component at bud neck; cell-cycle regulated ser phosphorylation at CDK sites regulate association with Bni1/Bnr1, Iqg1 degradation, and ring disassembly; mutation causes cytokinetic defects; rat catheter biofilm repressed
Coronin; cortical actin cytoskeletal component; predicted role in regulation of actin patch assembly; rat catheter and Spider biofilm repressed
Putative mitochondrial lysine-tRNA synthetase; flucytosine repressed
Ortholog(s) have FAD transmembrane transporter activity, role in FAD transport and mitochondrion localization
Predicted component of the TOM (translocase of outer membrane) complex involved in protein translocation into mitochondria; flucytosine induced
Putative NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); alkaline repressed; Hap43-repressed; Spider biofilm repressed
Similar to bacterial DnaJ; transcript upregulated in low iron; flow model biofilm induced; Spider biofilm induced
SCF E2 ubiquitin-protein ligase catalytic subunit
Putative ubiquitin-protein ligase; transcript regulated by Nrg1 and Tup1, and by Gcn2 and Gcn4; rat catheter biofilm induced
Ortholog of C. dubliniensis CD36 : Cd36_71740, C. parapsilosis CDC317 : CPAR2_703440, Candida tenuis NRRL Y-1498 : CANTEDRAFT_102923 and Debaryomyces hansenii CBS767 : DEHA2C03190g
Pheromone-regulated protein (Prm10) of S. cerevisiae; colony morphology-related gene regulation by Ssn6; induced by Mnl1 under weak acid stress; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
Ortholog(s) have COPI-coated vesicle, Golgi apparatus, nuclear periphery localization
S. cerevisiae ortholog Inp1 is a peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; induced by Mnl1 under weak acid stress
Protein involved in mitochondrial protein import; Spider biofilm repressed
(CEN7) Centromere region of Chromosome 7; each centromere mediates a single kinetochore attachment although it binds multiple (four) Cse4p-containing nucleosomes
Putative allantoate permease; Gcn4-regulated; Spider biofilm induced
Putative allantoate permease; fungal-specific (no human or murine homolog)
Predicted aldehyde dehydrogenase [NAD(P)+]; Spider biofilm induced
Putative DNA repair protein; transcription is regulated upon yeast-hyphal switch; flucytosine repressed
Essential chaperone, regulates several signal transduction pathways and temperature-induced morphogenesis; activated by heat shock, stress; localizes to surface of hyphae, not yeast cells; mediates echinocandin and biofilm azole resistance
Transcription factor; represses SOK1 expression in response to farnesol inhibition; yeast-hypha switch repressed; ketoconazole-induced; Plc1-regulated; colony morphology-related Ssn6 regulation; Spider, flow model biofilm induced
Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip
tRNA ligase; functional homolog of S. cerevisiae Trl1
Putative glutaredoxin; induced in low iron
Ortholog(s) have glutathione disulfide oxidoreductase activity and cytosol, nucleus localization
Ortholog(s) have GTPase activator activity, role in positive regulation of GTPase activity, positive regulation of TORC1 signaling and Lst4-Lst7 complex, cytosol, nucleus, vacuolar membrane localization
Putative curved DNA-binding protein orthologous to S. pombe Cdb4; stationary phase enriched protein; rat catheter and Spider biofilm repressed
Ortholog(s) have role in histone deacetylation, negative regulation of antisense RNA transcription and positive regulation of transcription from RNA polymerase II promoter, more
mitochondrial 54S ribosomal protein MRP49
Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translation and mitochondrial large ribosomal subunit localization
Short-chain dehydrogenase/reductase; upregulation correlates with clinical development of fluconazole resistance
Ortholog of C. dubliniensis CD36 : Cd36_71960, Pichia stipitis Pignal : psti_CGOB_00136, Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_63786 and Candida tropicalis MYA-3404 : CTRG_05049
Ornithine acetyltransferase; Gcn2, Gcn4-regulated; clade-specific gene expression; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced
Predicted DNA-directed RNA polymerase; role in transcription; Spider biofilm induced
Ortholog(s) have role in RNA polymerase II complex import to nucleus, RNA polymerase III complex localization to nucleus and DNA-directed RNA polymerase II, holoenzyme, cytoplasm localization
Putative TRAPP complex subunit; constitutive expression independent of MTL or white-opaque status
(snR8c) H/ACA box small nucleolar RNA (snoRNA)
Putative RNA binding protein; induced during infection of murine kidney, compared to growth in vitro; has murine homolog
Ortholog of C. dubliniensis CD36 : Cd36_72020 and Candida albicans WO-1 : CAWG_05570
Predicted protein serine/threonine kinase and/or protein tyrosine kinase; Spider biofilm induced
Predicted membrane protein induced during mating; mutation confers hypersensitivity to toxic ergosterol analog, to amphotericin B; alkaline repressed; repressed by alpha pheromone in SpiderM medium; rat catheter, Spider biofilm induced
Ortholog of C. dubliniensis CD36 : Cd36_72050, C. parapsilosis CDC317 : CPAR2_301140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135055 and Debaryomyces hansenii CBS767 : DEHA2E07678g
Ortholog of C. parapsilosis CDC317 : CPAR2_808350, C. dubliniensis CD36 : Cd36_72060, Candida orthopsilosis Co 90-125 : CORT_0C00820 and Candida albicans WO-1 : CAWG_05575
Putative LDG family protein; F-12/CO2 early biofilm induced
Ortholog of C. parapsilosis CDC317 : CPAR2_808370, C. dubliniensis CD36 : Cd36_72070, Candida orthopsilosis Co 90-125 : CORT_0C00800 and Candida albicans WO-1 : CAWG_05577
Protein of unknown function; induced by nitric oxide independent of Yhb1p; regulated by Sef1, Sfu1, and Hap43; rat catheter biofilm induced
Putative aspartic-type endopeptidase with limited ability to degrade alpha pheromone; mutants show increased sensitivity to alpha pheromone
Ortholog(s) have role in UDP-glucose transport and COPI-coated vesicle, Golgi apparatus localization
Ortholog(s) have SNARE binding activity and role in positive regulation of vesicle fusion, vesicle docking involved in exocytosis
ATP-binding cassette glutathione S-conjugate transporter
Putative glutathione S-conjugate transporter; MRP/CFTR-subfamily, ABC type transporter; human neutrophil-induced; oxidative stress-induced via Cap1; possible association with multidrug resistance; possibly essential; Spider biofilm induced
Ortholog(s) have tRNA (guanine-N7-)-methyltransferase activity, role in tRNA methylation and cytosol, nucleus, tRNA methyltransferase complex localization
Putative protein with a predicted role in exocytic transport from the Golgi; filament induced
Protein of unknown function; flow model biofilm induced
Protein with chitin synthesis regulation, resistance to Congo red domain; membrane-localized protein; Spider biofilm induced
Peptidyl-prolyl cis-trans isomerase; cyclosporin A sensitive activity; soluble in hyphae; biofilm induced, macrophage-induced protein; downregulated upon treatment of biofilm with farnesol; present in exponential and stationary phase cells
Putative thiol-specific peroxiredoxin; macrophage-downregulated gene
(Tca11-7) Retrotransposon Tca11 on Chromosome 7, member of the gypsy group, flanked by 470-bp LTRs (eta elements)
(eta-7b) Long terminal repeat (LTR) associated with the transposon Tca11; about 470 bp long, 13 copies per genome
Predicted ORF in retrotransposon Tca11 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase
Ortholog of C. dubliniensis CD36 : Cd36_83910, Candida tropicalis MYA-3404 : CTRG_05087 and Candida albicans WO-1 : CAWG_00654
(eta-7a) Long terminal repeat (LTR) associated with the transposon Tca11; about 470 bp long, 13 copies per genome
Protein of unknown function; induced upon adherence to polystyrene; oxidative stress-induced via Cap1
Putative ortholog of S. cerevisiae Npa3p; possibly essential for growth (however, depletion mutant is viable)
Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex, cytosol localization
Ortholog(s) have unfolded protein binding activity, role in aerobic respiration, mitochondrial respiratory chain complex IV assembly, protein processing and mitochondrial inner membrane localization
Ortholog(s) have ATPase activity, protein heterodimerization activity, role in fatty acid metabolic process, protein import into peroxisome matrix, receptor recycling and peroxisomal membrane localization
bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase
Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1; required for farnesol biosynthesis; repressed by 17-beta-estradiol, ethynyl estradiol; Spider biofilm induced
Ortholog(s) have U6 snRNA binding activity and role in cytoplasmic mRNA processing body assembly, mRNA splicing, via spliceosome
Ortholog of C. dubliniensis CD36 : Cd36_72260, C. parapsilosis CDC317 : CPAR2_702840, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115664 and Debaryomyces hansenii CBS767 : DEHA2B05940g
Ortholog of S. cerevisiae : YBL086C, C. glabrata CBS138 : CAGL0C01815g, C. dubliniensis CD36 : Cd36_72270, C. parapsilosis CDC317 : CPAR2_702850 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_107537
Ortholog of C. dubliniensis CD36 : Cd36_72280, C. parapsilosis CDC317 : CPAR2_703040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_125842 and Debaryomyces hansenii CBS767 : DEHA2B05984g
Protein of unknown function, transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis
Ortholog of C. dubliniensis CD36 : Cd36_72300, C. parapsilosis CDC317 : CPAR2_703060, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92002 and Debaryomyces hansenii CBS767 : DEHA2B06028g
Peptidyl-prolyl cis-trans isomerase; rapamycin-binding protein; homozygous null mutation confers rapamycin resistance; regulated by Gcn4p; macrophage-induced protein; repressed in response to 3-AT; functional homolog of S. cerevisiae Rbp1p
(Tca2-7) Retrotransposon Tca2 on Chromosome 7, about 6.4 kbp member of the copia group with two ORFs similar to gag and pol, flanked by 280-bp LTRs (gamma elements); forms an extrachromosomal, linear, double-stranded DNA (pCal)
(gamma-7b) Long terminal repeat (LTR) associated with the transposon Tca2; about 280 bp long, 5-10 copies per genome
Pol protein of retrotransposon Tca2; separated by a stop codon from Gag protein orf19.2371; likely translated as single polyprotein with Gag, reverse transcriptase, protease, and integrase; rat catheter biofilm repressed
Putative Gag protein of retrotransposon Tca2; separated by a stop codon from Pol protein orf19.2372; likely translated as single polyprotein that includes Gag, reverse transcriptase, protease, and integrase; rat catheter biofilm repressed
(gamma-7a) Long terminal repeat (LTR) associated with the transposon Tca2; about 280 bp long, 5-10 copies per genome
Protein of unknown function; mutants are viable; ortholog of S. cervisiae Art10, a protein of unknown function
Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity and role in protein import into mitochondrial inner membrane, protein import into mitochondrial matrix
putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Tep1p
Protein of unknown function that may function in RNA processing; filament induced
Ortholog(s) have role in ascospore formation, intra-S DNA damage checkpoint, positive regulation of macroautophagy, re-entry into mitotic cell cycle after pheromone arrest and regulation of meiosis I, more
Putative mitochondrial import receptor subunit; colony morphology-related gene regulation by Ssn6
bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
Ortholog(s) have diacylglycerol cholinephosphotransferase activity, ethanolaminephosphotransferase activity, role in phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process and Golgi apparatus localization
(MRS-7b) Major Repeat Sequence (MRS) on Chromosome 7; MRS units are composed of variable numbers of RPS units flanked by HOK and RB2 sequences; found on most chromosomes; may serve as recombination hot spot
(HOK-7b) Repeat sequence of about 8 kb, part of the Major Repeat Sequence (MRS) on Chromosome 7; MRS units are found on most chromosomes; may serve as recombination hotspots
(Ca3-7a) Ca3 region on Chromosome 7; Ca3 is a large dispersed repeat sequence utilized as species-specific and strain-specific RFLP probe
(RPS-7b) Repeat sequence of about 2 kb on Chromosome 7, about 60 copies are found in tandem repeats on most chromosomes; RPS units flanked by conserved HOK and RB2 sequences form Major Repeat Sequence (MRS); may serve as recombination hot spot
(RB2-7b) Repeat sequence of about 6 kb, part of the Major Repeat Sequence (MRS) on Chromosome 7; MRS units are found on most chromosomes; may serve as recombination hotspots
Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth
Chitin synthase; essential; for primary septum synthesis in yeast and hyphae; 1 of several chitin synthases; enzymatically activated by proteolytic processing; complements defects of S. cerevisiae chs1 or chs2; Spider biofilm repressed
Putative Ran guanyl-nucleotide exchange factor; probable signal transducer; Spider biofilm repressed
Large subunit of DNA polymerase III; partially complements defects of an S. cerevisiae cdc2 mutant; differing reports about periodic (G1/S) or non-periodic mRNA expression through cell cycle; Hap43p-repressed
Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; required for wild-type virulence in mouse systemic infection but not for wild-type growth or drug sensitivity/resistance; 9 HAMP domains
Thioredoxin peroxidase; transcriptionally induced by interaction with macrophage; fluconazole induced; Fkh2p-downregulated; caspofungin repressed; protein present in exponential and stationary growth phase yeast cultures
(rho-7a) Long terminal repeat (LTR); about 275 bp long, 13 copies per genome
Cold-activated secreted lipase, differentially expressed lipase gene family member with possible roles in nutrition and acidic microenvironment; LIP5 and LIP8 expressed at all stages of mucosal and systemic infection; affects filamentation
Putative C-22 sterol desaturase; fungal C-22 sterol desaturases are cytochrome P450 enzymes of ergosterol biosynthesis, catalyze formation of the C-22(23) double bond in the sterol side chain; transposon mutation affects filamentous growth
Ortholog of Candida albicans WO-1 : CAWG_05627
Ortholog(s) have ubiquitin protein ligase activity and role in ER-associated ubiquitin-dependent protein catabolic process
Putative TFIID subunit; mutation confers hypersensitivity to amphotericin B; rat catheter biofilm induced
Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment
dolichyl-phosphate-mannose-protein mannosyltransferase
Protein mannosyltransferase; required for virulence in mice and for adhesion to epithelial cells; role in hyphal growth and drug sensitivity; Als1, Sec20, Kre9, Pir1 are substrates; 1 of 5 PMT family members
Predicted P-type ATPase sodium pump; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame; Spider biofilm induced
Has domain(s) with predicted carbon-nitrogen ligase activity, with glutamine as amido-N-donor activity
Ortholog(s) have role in maturation of SSU-rRNA and cytosol, nucleolus localization
Putative mitochondrial translation initiation factor; transcript regulated by Nrg1, Mig1, and Tup1
protein serine/threonine kinase activating protein
Putative Cdc7p-Dbf4p kinase complex regulatory subunit; Hap43p-induced gene; macrophage/pseudohyphal-repressed; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulated
dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase
Putative mannosyltransferase similar to S. cerevisiae Ecm39p, which has a role in Calcofluor white resistance; predicted Kex2p substrate; has HKEXRF motif
Putative centrin-binding protein; predicted role in spindle pole body duplication; induced by alpha pheromone in SpiderM medium; essential for growth
mitogen-activated protein kinase kinase kinase
Ortholog of S. cerevisiae Bck1; MAP kinase kinase kinase of cell integrity pathway; mutant is hypersensitive to caspofungin
mitochondrial 54S ribosomal protein YmL49
Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
Ortholog(s) have role in G1/S transition of mitotic cell cycle, TOR signaling, dephosphorylation, regulation of mitotic sister chromatid segregation, tRNA wobble uridine modification
Putative glutamine amidotransferase (GATase II); role in glutathione catabolism
Protein with similarity to a human gene associated with colon cancer and to orf19.5158; regulated by Gcn4, Cyr1; induced by amino acid starvation; macrophage-induced protein, macrophage-repressed; Spider biofilm induced
Protein with a protein tyrosine phosphatase-like protein domain; putative membrane-spanning regions; rat catheter biofilm induced
Protein similar to S. cerevisiae Phs1p, which is required for growth; has six putative membrane-spanning regions
Protein with tetratricopeptide repeats (TPRs); ortholog of S. cerevisiae Chs6, which has role in localizing chitin synthase; Cyr1-regulated in hyphae; possibly essential, disruptants not obtained by UAU1 method; flow model biofilm repressed
Class III adenylyl cyclase; mutant lacks cAMP; mutant hyphal growth defect rescued by exogenous cAMP; required for mouse mucosal or systemic infection; role in macrophage sensitivity, apoptosis; downstream of Ras1p and CO2 signaling
Protein involved together with Dck1p and Rac1p in invasive filamentous growth and cell wall integrity; acts upstream of MAP kinase Cek1p; has similarity to human ELMO1
Putative flavin-containing monooxygenase; F-12/CO2 early biofilm induced
(psi-7a) Solo copy of the long terminal repeat (LTR) associated with the transposon Tca9; about 470 bp long, 30 copies per genome
Protein similar to S. cerevisiae Wsc2p, which has roles in stress- and cell-wall-related processes; predicted Kex2p substrate; putative GPI-anchored adhesin-like protein
Predicted component of the mitochondrial TIM22 complex; involved in protein import into mitochondrial inner membrane; Spider biofilm repressed
Trimethoprim resistant dihydrofolate reductase (DHFR), reduces 7,8-dihydrofolate to 5,4,7,8-tetrahydrofolate; binds NADPH; target of drugs that selectively inhibit the fungal enzyme rather than the human enzyme
Ortholog of Candida albicans WO-1 : CAWG_05647
Protein of unknown function; rat catheter and Spider biofilm induced
Ortholog of C. dubliniensis CD36 : Cd36_72800, Candida tropicalis MYA-3404 : CTRG_05211 and Candida albicans WO-1 : CAWG_05649
IPF family A protein; mutants are viable; Spider biofilm induced
Putative histone H1; farnesol regulated; Hap43-induced; contains 5' UTR intron; Spider biofilm repressed
Putative pyridoxamine 5'-phosphate oxidase; planktonic growth and early-stage flow model biofilm induced
Ortholog of C. parapsilosis CDC317 : CPAR2_704140, C. dubliniensis CD36 : Cd36_72870, Lodderomyces elongisporus NRLL YB-4239 : LELG_05208 and Candida orthopsilosis Co 90-125 : CORT_0G04320
Zn(II)2Cys6 transcription factor; mutants sensitive to caffeine and menadione, resistant to fenpropimorph; Hap43-repressed; mutants have decreased CFU in mouse kidneys and defects in filamentous growth; Spider biofilm induced
Protein of unknown function; transcript detected on high-resolution tiling arrays; Spider biofilm induced
glucose-induced degradation complex subunit
Ortholog of S. cerevisiae Gid7, a GID complex protein; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Hap43-repressed gene
Putative protein disulfide-isomerase; antigenic in human infection; soluble protein in hyphae; induced by filamentous growth; protein present in exponential and stationary growth phase yeast cultures; flow model biofilm repressed
Ortholog of C. dubliniensis CD36 : Cd36_72910, C. parapsilosis CDC317 : CPAR2_704100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113193 and Debaryomyces hansenii CBS767 : DEHA2E23100g
Protein of unknown function; induced by ketoconazole; Spider, F-12/CO2 and flow model biofilm induced
Cell wall adhesin-like protein; repressed by Rim101; possibly an essential gene, disruptants not obtained by UAU1 method
Secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition and/or in creating an acidic microenvironment; LIP5 and LIP8 are expressed at all stages of both mucosal and systemic infection
Protein of unknown function; fluconazole-induced; Spider biofilm induced
Putative RNA polymerase II mediator complex subunit; induced by nitric oxide
Mitochondrial serine hydroxymethyltransferase; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; protein present in exponential and stationary growth phase yeast cultures
Putative serine/threonine protein kinase; mutation confers resistance to 5-fluorocytosine (5-FC)
Putative aldose reductase; protein level decreases in stationary phase cultures; Spider biofilm repressed
Carboxypeptidase Y; transcript regulated at yeast-hypha transition or macrophage response; induced human neutrophils; regulated by Gcn2 and Gcn4; putative N-glycosylation
Protein of unknown function; possible COPI-coated vesicle, Golgi apparatus, ribosome localization; rat catheter biofilm repressed
Ortholog(s) have role in mitochondrial respiratory chain complex assembly and mitochondrial intermembrane space, nucleus localization
Putative beta 3 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed
Ortholog of S. cerevisiae Mtr4, an ATP-dependent 3'-5' RNA helicase of the DEAD-box family; Hap43-induced gene; Spider biofilm induced
Protein of unknown function; repressed by alpha pheromone in SpiderM medium
Putative membrane transporter; Hap43p-induced gene; mutation confers hypersensitivity to toxic ergosterol analog; shows colony morphology-related gene regulation by Ssn6p
(koppa-7a) Long terminal repeat (LTR); about 208 bp long, 10 copies per genome
Putative membrane transporter; Hap43-induced; inducd by Mnl1p under weak acid stress; shows Mob2-dependent hyphal regulation
Ortholog(s) have role in mismatch repair, proteasome regulatory particle assembly and cytosol, nucleus, proteasome regulatory particle, base subcomplex localization
Ortholog of Candida albicans WO-1 : CAWG_05678
Protein of unknown function; Hap43-repressed gene
Arf family guanine nucleotide exchange factor
Putative guanyl nucleotide exchange factor with Sec7 domain; required for normal filamentous growth; regulated by yeast-hyphal switch; filament induced; regulated by Nrg1, Tup1, Mob2, Hap43; mRNA binds She3; Spider biofilm induced
Protein similar to S. cerevisiae Gyp7p (GTPase-activating protein for Ypt1p); caspofungin-induced
putative serine/threonine-protein phosphatase
Predicted vacuolar protein with a calcineurin-like phosphoesterase domain; repressed by alpha pheromone in SpiderM medium
(psi-7b) Solo copy of the long terminal repeat (LTR) associated with the transposon Tca9; about 470 bp long, 30 copies per genome
Putative nicotinamidase, involved in NAD salvage pathway; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1
Putative pre-mRNA-splicing factor; mutation confers resistance to 5-fluorocytosine (5-FC); rat catheter biofilm induced
Putative nucleolar protein; essential; heterozygous mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Hap43-induced; Spider biofilm induced
Protein of unknown function; rat catheter biofilm repressed
Protein of unknown function; expression decreases by benomyl treatment or in an azole-resistant strain overexpressing MDR1; Spider biofilm induced
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway; alkaline downregulated; flow model biofilm induced; Spider biofilm induced
Putative ember of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide exporter superfamily; Spider biofilm induced
Putative alpha-1,2-mannosyltransferase; mutant sensitive to calcofluor, SDS and growth at 42 deg; present in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation and transmembrane helix
Ortholog of C. dubliniensis CD36 : Cd36_73320, C. parapsilosis CDC317 : CPAR2_703860, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114480 and Debaryomyces hansenii CBS767 : DEHA2C13794g
Predicted protein of the mitochondrial intermembrane space; rat catheter biofilm induced; Spider biofilm repressed
Ortholog(s) have asparagine-tRNA ligase activity, role in mitochondrial asparaginyl-tRNA aminoacylation and mitochondrion localization
Ortholog(s) have histidinol-phosphatase activity, role in histidine biosynthetic process and cytosol, nucleus localization
Protein with similarity to amino acid-tRNA ligase; stationary phase enriched protein; GlcNAc-induced protein
Putative tRNA-Asn synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures
Ortholog of C. dubliniensis CD36 : Cd36_73260 and Candida albicans WO-1 : CAWG_05699
Ortholog of Candida albicans WO-1 : CAWG_05700
Protein required for pre-rRNA processing and 40S ribosomal subunit synthesis; associated with U3 and U14 snoRNAs; transposon mutation affects filamentous growth; repressed by prostaglandins; Spider biofilm induced
Phosphoinositide-specific phospholipase C (PI-PLC), delta-form; essential; roles in stress resistance, hyphal growth; upregulated in biofilm; predicted N-linked glycosylation; lacks conserved EF-hand domain
Putative imidazole glycerol phosphate synthase; histidine biosynthesis; no human/murine homolog; transcription induced by histidine starvation; regulated by Gcn2p and Gcn4p; higher protein level in stationary phase
Ortholog of C. dubliniensis CD36 : Cd36_73400, C. parapsilosis CDC317 : CPAR2_703180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104803 and Debaryomyces hansenii CBS767 : DEHA2A04466g
(mu-7a) Long terminal repeat (LTR); about 780 bp long, 4 copies per genome
Ortholog of C. dubliniensis CD36 : Cd36_73420, Debaryomyces hansenii CBS767 : DEHA2A05456g, Pichia stipitis Pignal : PICST_30999 and Candida guilliermondii ATCC 6260 : PGUG_00155
Subunit of the NuA4 histone acetyltransferase complex; transcript regulated by Mig1; possibly an essential gene, disruptants not obtained by UAU1 method
Ortholog(s) have glyoxysome localization
mitochondrial 54S ribosomal protein YmL2
Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced
Ortholog(s) have role in ER to Golgi vesicle-mediated transport, protein retention in ER lumen, retrograde vesicle-mediated transport, Golgi to ER
Actin binding protein with roles in growth control and morphogenesis; required for alkaline pH-induced hyphal formation; localized to actin patches; rat catheter biofilm repressed
Ortholog of C. dubliniensis CD36 : Cd36_73480, Pichia stipitis Pignal : PICST_30727, Candida tropicalis MYA-3404 : CTRG_05165 and Candida albicans WO-1 : CAWG_05712
Ortholog(s) have role in posttranslational protein targeting to membrane and TRC complex, nucleus localization
CCR4-NOT complex component; involved in controlling mRNA initiation, elongation and degradation; rat catheter biofilm induced
Putative intranuclear transport and DNA replication mediator; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Spider biofilm induced
Putative vacuolar protease; upregulated in the presence of human neutrophils; Spider biofilm induced
Functional ortholog of S. cerevisiae Rad6; negative regulator of hyphal growth; required for wild-type UV resistance; acts in pathway with Efg1; transcript is UV-induced, slightly repressed during hyphal growth; gene has two introns
Protein required for virulence in reconstituted human epithelium (RHE) model of ex vivo infection; decreased transcription is observed upon fluphenazine treatment; induced upon adherence to polystyrene
Specificity factor required for ubiquitination; role in protein targeting to vacuole; involved in ubiquitin-dependent protein catabolism via the multivesicular body sorting pathway; Spider biofilm induced
Mitochondrial glycosylase/lyase; repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance, role in base-excision repair; Spider biofilm induced
Conserved acidic ribosomal protein, likely involved in regulation of translation elongation; interacts with Rpp2A; 1 of 4 similar C. albicans ribosomal proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); induced by Tbf1; Spider biofilm repressed
Putative mitochondrial acidic matrix protein; regulated by Ssn6p; protein present in exponential and stationary growth phase yeast cultures
B-type mitotic cyclin; nonessential; negative regulator of pseudohyphal growth; dispensible for mitotic exit, cytokinesis; Fkh2-represed; flow model biofilm repressed; farnesol-upregulated in biofilm; reduced total RNA in clb4 mutant
(tL(UAA)5) tRNA-Leu, predicted by tRNAscan-SE; UAA anticodon
Ortholog of C. dubliniensis CD36 : Cd36_73630, C. parapsilosis CDC317 : CPAR2_805330, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119330 and Debaryomyces hansenii CBS767 : DEHA2G16544g
Ortholog of C. dubliniensis CD36 : Cd36_73640, C. parapsilosis CDC317 : CPAR2_702340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112965 and Debaryomyces hansenii CBS767 : DEHA2G16566g
Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization
Ortholog(s) have RNA binding activity, role in tRNA modification and cytoplasm, nucleus localization
Ortholog of C. dubliniensis CD36 : Cd36_73670, C. parapsilosis CDC317 : CPAR2_702370, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119320 and Debaryomyces hansenii CBS767 : DEHA2G16632g
Ortholog(s) have role in intracellular sequestering of iron ion, iron-sulfur cluster assembly, protein maturation and mitochondrial matrix localization
proteasome core particle subunit alpha 6
Alpha6 subunit of the 20S proteasome; regulated by Gcn4; induced in response to amino acid starvation (3-AT); Spider biofilm repressed
Putative karyopherin; mutation confers hypersensitivity to cytochalasin D
Putative nicotinate phosphoribosyltransferase, involved in NAD salvage pathway; fungal-specific (no human or murine homolog)
Putative HSP40 co-chaperone; repressed during the mating process
Ortholog of C. parapsilosis CDC317 : CPAR2_702310, C. dubliniensis CD36 : Cd36_73730, Lodderomyces elongisporus NRLL YB-4239 : LELG_04029 and Candida orthopsilosis Co 90-125 : CORT_0G02490
Ortholog of C. dubliniensis CD36 : Cd36_73740, Candida tropicalis MYA-3404 : CTRG_05151 and Candida albicans WO-1 : CAWG_05736
Predicted mitochondrial cardiolipin-specific phospholipase; upregulated in an azole-resistant strain that overexpresses MDR1; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced
RNA polymerase II mediator complex subunit; Hap43p-repressed gene
putative serine/threonine protein kinase
Ortholog(s) have role in ascospore formation, conidiophore development, conidium formation, regulation of vacuole fusion, non-autophagic and response to oxidative stress, more
Ortholog of C. dubliniensis CD36 : Cd36_73790, C. parapsilosis CDC317 : CPAR2_702880, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92070 and Debaryomyces hansenii CBS767 : DEHA2D10318g
translation initiation factor eIF2 subunit beta
Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
Ortholog(s) have unfolded protein binding activity
Putative protein of unknown function; Hap43p-repressed gene; ortholog of S. cerevisiae YMR185W
Protein of allantoate permease family; fungal-specific (no human or murine homolog); Hap43p-repressed gene
Protein with a tubulin binding cofactor C domain; flow model biofilm induced
Putative U3 snoRNA-associated protein; Hap43-induced; repressed in core stress response; physically interacts with TAP-tagged Nop1
Putative exportin, member of the Exportin-T family; flow model biofilm repressed
Protein similar to Aspergillus CYSK O-acetylserine sulfhydrylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; upregulated in biofilm; protein level decreases in stationary phase cultures
Transcription factor/repressor; regulates chlamydospore formation/hyphal gene induction/virulence and rescue/stress response genes; effects both Tup1 dependent and independent regulation; flow model biofilm induced; Spider biofilm repressed
Putative GTPase inhibitor; predicted role in endocytosis, protein targeting to vacuole; rat catheter biofilm repressed
Putative polyamine transport protein; fungal-specific (no human or murine homolog)
Ortholog(s) have GTPase activity, ribosome binding activity and role in nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, positive regulation of translation, ribosome disassembly
Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; functional homolog of S. cerevisiae Ufe1p, which is an ER t-SNARE that mediates the retrograde traffic
Putative catechol o-methyltransferase; stationary phase enriched protein; transcription upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed
Ortholog(s) have role in mRNA splicing, via spliceosome
Putative transcription elongation factor; transposon mutation affects filamentous growth; transcript induced in an RHE model of oral candidiasis and in clinical isolates from oral candidiasis
Butyrobetaine dioxygenase, the fourth enzyme of the carnitine biosynthesis pathway
Putative Golgi integral membrane protein; transcript regulated by Mig1
Putative protein of unknown function, transcript is upregulated in an RHE model of oral candidiasis
(san-7a) Solo copy of the long terminal repeat (LTR) associated with the transposon Tca4; about 381 bp long, 1-4 copies per genome
Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo