Metamycoplasma arthritidis strain NCTC10162 chromosome 1.
Metamycoplasma arthritidis (Mycoplasma arthritidis)
Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae; Metamycoplasma.
Submitted (24-JAN-2019) WTSI, Pathogen Informatics, Wellcome Trust Sanger Institute, CB10 1SA, United Kingdom
REFSEQ INFORMATION: The reference sequence is identical to\nLR215047.1.\nThe annotation was added by the NCBI Prokaryotic Genome Annotation\nPipeline (PGAP). Information about PGAP can be found here:\nhttps://www.ncbi.nlm.nih.gov/genome/annotation_prok/\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: NCBI RefSeq\nAnnotation Date :: 05/01/2023 02:07:34\nAnnotation Pipeline :: NCBI Prokaryotic Genome\n Annotation Pipeline (PGAP)\nAnnotation Method :: Best-placed reference protein\n set; GeneMarkS-2+\nAnnotation Software revision :: 6.5\nFeatures Annotated :: Gene; CDS; rRNA; tRNA; ncRNA\nGenes (total) :: 649\nCDSs (total) :: 610\nGenes (coding) :: 605\nCDSs (with protein) :: 605\nGenes (RNA) :: 39\nrRNAs :: 1, 1, 1 (5S, 16S, 23S)\ncomplete rRNAs :: 1, 1, 1 (5S, 16S, 23S)\ntRNAs :: 33\nncRNAs :: 3\nPseudo Genes (total) :: 5\nCDSs (without protein) :: 5\nPseudo Genes (ambiguous residues) :: 0 of 5\nPseudo Genes (frameshifted) :: 1 of 5\nPseudo Genes (incomplete) :: 4 of 5\nPseudo Genes (internal stop) :: 0 of 5\nCRISPR Arrays :: 1\n##Genome-Annotation-Data-END##
COORDINATES: similar to AA sequence:RefSeq:WP_004425374.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
chromosomal replication initiator protein DnaA
COORDINATES: similar to AA sequence:RefSeq:WP_012855286.1
GO:0009360 - DNA polymerase III complex [Evidence IEA]
GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]
GO:0006260 - DNA replication [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881393.1
RNA-binding S4 domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_011113782.1
GO:0022625 - cytosolic large ribosomal subunit [Evidence IEA]; GO:0000311 - plastid large ribosomal subunit [Evidence IEA]
GO:0003735 - structural constituent of ribosome [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002384.1
COORDINATES: similar to AA sequence:RefSeq:WP_012497931.1
GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence IEA]
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA
COORDINATES: similar to AA sequence:RefSeq:WP_020002449.1
GO:0008897 - holo-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO:0000287 - magnesium ion binding [Evidence IEA]
4'-phosphopantetheinyl transferase superfamily protein
COORDINATES: similar to AA sequence:RefSeq:WP_002881910.1
lysophospholipid acyltransferase family protein
COORDINATES: similar to AA sequence:RefSeq:WP_020002451.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855318.1
GO:0005515 - protein binding [Evidence IEA]
GO:0007059 - chromosome segregation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855319.1
GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]
GO:0001522 - pseudouridine synthesis [Evidence IEA]
COORDINATES: protein motif:HMM:NF014716.2
GO:0005524 - ATP binding [Evidence IEA]; GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IEA]
GO:0006450 - regulation of translational fidelity [Evidence IEA]
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC
COORDINATES: similar to AA sequence:RefSeq:WP_012855321.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002454.1
GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]
Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB
COORDINATES: similar to AA sequence:RefSeq:WP_004423119.1
YihY/virulence factor BrkB family protein
COORDINATES: similar to AA sequence:RefSeq:WP_002881920.1
GO:0022857 - transmembrane transporter activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF012361.2
GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA]; GO:0000166 - nucleotide binding [Evidence IEA]; GO:0004832 - valine-tRNA ligase activity [Evidence IEA]
GO:0006438 - valyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855781.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [Evidence IEA]
GO:0006265 - DNA topological change [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002523.1
COORDINATES: ab initio prediction:GeneMarkS-2+
Derived by automated computational analysis using gene prediction method: GeneMarkS-2+.
COORDINATES: similar to AA sequence:RefSeq:WP_012855779.1
GO:0016805 - dipeptidase activity [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence IEA]
Sapep family Mn(2+)-dependent dipeptidase
Derived by automated computational analysis using gene prediction method: tRNAscan-SE.
COORDINATES: similar to AA sequence:RefSeq:WP_002881271.1
COORDINATES: similar to AA sequence:RefSeq:WP_012497949.1
GO:0005525 - GTP binding [Evidence IEA]; GO:0003924 - GTPase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002518.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881619.1
GO:0016787 - hydrolase activity [Evidence IEA]
GO:0008152 - metabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012497953.1
COORDINATES: similar to AA sequence:RefSeq:WP_012497952.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002549.1
GO:0004827 - proline-tRNA ligase activity [Evidence IEA]
GO:0006433 - prolyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012497956.1
GO:0000287 - magnesium ion binding [Evidence IEA]; GO:0008973 - phosphopentomutase activity [Evidence IEA]
GO:0043094 - cellular metabolic compound salvage [Evidence IEA]; GO:0009117 - nucleotide metabolic process [Evidence IEA]
COORDINATES: protein motif:HMM:NF004491.0
GO:0004743 - pyruvate kinase activity [Evidence IEA]
GO:0006096 - glycolytic process [Evidence IEA]
COORDINATES: protein motif:HMM:NF020806.2
COORDINATES: similar to AA sequence:RefSeq:WP_002882055.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002882060.1
COORDINATES: similar to AA sequence:RefSeq:WP_012497962.1
GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO:0045264 - plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO:0045263 - proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]
GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]
GO:0015986 - proton motive force-driven ATP synthesis [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012497963.1
COORDINATES: similar to AA sequence:RefSeq:WP_012497964.1
COORDINATES: similar to AA sequence:RefSeq:WP_012497965.1
GO:0000275 - mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [Evidence IEA]; GO:0045262 - plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA]; GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002441.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424778.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424780.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881904.1
GO:0006813 - potassium ion transport [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855735.1
COORDINATES: similar to AA sequence:RefSeq:WP_004423230.1
GO:0033862 - UMP kinase activity [Evidence IEA]
GO:0015949 - nucleobase-containing small molecule interconversion [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498380.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881578.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]; GO:0016987 - sigma factor activity [Evidence IEA]
GO:0006352 - DNA-templated transcription initiation [Evidence IEA]; GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]
sigma factor-like helix-turn-helix DNA-binding protein
COORDINATES: similar to AA sequence:RefSeq:WP_012855733.1
GO:0003924 - GTPase activity [Evidence IEA]; GO:0005047 - signal recognition particle binding [Evidence IEA]
GO:0009306 - protein secretion [Evidence IEA]
signal recognition particle-docking protein FtsY
COORDINATES: similar to AA sequence:RefSeq:WP_012497975.1
GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO:0000314 - organellar small ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012497976.1
GO:0003746 - translation elongation factor activity [Evidence IEA]
GO:0006414 - translational elongation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002395.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855526.1
endonuclease/exonuclease/phosphatase family protein
COORDINATES: similar to AA sequence:RefSeq:WP_012497988.1
GO:0009380 - excinuclease repair complex [Evidence IEA]
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0016787 - hydrolase activity [Evidence IEA]; GO:0005515 - protein binding [Evidence IEA]
GO:0006289 - nucleotide-excision repair [Evidence IEA]
COORDINATES: protein motif:HMM:NF024702.2
leucine-rich repeat domain-containing protein
COORDINATES: protein motif:HMM:NF014664.2
GO:0051920 - peroxiredoxin activity [Evidence IEA]
carboxymuconolactone decarboxylase family protein
COORDINATES: protein motif:HMM:NF014344.2
COORDINATES: similar to AA sequence:RefSeq:WP_020002556.1
GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IEA]
GO:0006400 - tRNA modification [Evidence IEA]
tRNA (guanosine(46)-N7)-methyltransferase TrmB
COORDINATES: similar to AA sequence:RefSeq:WP_004423538.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855673.1
transcription termination/antitermination protein NusG
COORDINATES: similar to AA sequence:RefSeq:WP_020002534.1
COORDINATES: similar to AA sequence:RefSeq:WP_004416875.1
GO:0022625 - cytosolic large ribosomal subunit [Evidence IEA]; GO:0000315 - organellar large ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498001.1
GO:0140741 - tRNA U4 sulfurtransferase [Evidence IEA]
GO:0009228 - thiamine biosynthetic process [Evidence IEA]; GO:0006400 - tRNA modification [Evidence IEA]
COORDINATES: protein motif:HMM:NF012738.2
GO:0055085 - transmembrane transport [Evidence IEA]
COORDINATES: protein motif:HMM:NF018367.2
alkylphosphonate ABC transporter substrate-binidng protein
COORDINATES: protein motif:HMM:NF033817.2
COORDINATES: similar to AA sequence:RefSeq:WP_012855634.1
GO:0003676 - nucleic acid binding [Evidence IEA]
S1 RNA-binding domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_012498007.1
COORDINATES: protein motif:HMM:NF012235.2
ATP-binding cassette domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_002881325.1
GO:0015444 - P-type magnesium transporter activity [Evidence IEA]
GO:0015693 - magnesium ion transport [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881324.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0016301 - kinase activity [Evidence IEA]; GO:0000287 - magnesium ion binding [Evidence IEA]; GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA]
GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO:0009165 - nucleotide biosynthetic process [Evidence IEA]; GO:0016310 - phosphorylation [Evidence IEA]; GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002470.1
GO:0005575 - cellular_component [Evidence IEA]
GO:0008168 - methyltransferase activity [Evidence IEA]
GO:0046118 - 7-methylguanosine biosynthetic process [Evidence IEA]; GO:0031167 - rRNA methylation [Evidence IEA]
16S rRNA (guanine(527)-N(7))-methyltransferase RsmG
COORDINATES: similar to AA sequence:RefSeq:WP_004423792.1
GO:0140359 - ABC-type transporter activity [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF025865.2
COORDINATES: similar to AA sequence:RefSeq:WP_004416250.1
COORDINATES: protein motif:HMM:TIGR00613.1
GO:0006310 - DNA recombination [Evidence IEA]; GO:0006281 - DNA repair [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855612.1
GO:0004540 - ribonuclease activity [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_006608558.1
GO:0004585 - ornithine carbamoyltransferase activity [Evidence IEA]
GO:0042450 - arginine biosynthetic process via ornithine [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881372.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0008804 - carbamate kinase activity [Evidence IEA]
GO:0019546 - arginine deiminase pathway [Evidence IEA]; GO:0016310 - phosphorylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881370.1
GO:0008173 - RNA methyltransferase activity [Evidence IEA]
GO:0009451 - RNA modification [Evidence IEA]
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB
COORDINATES: similar to AA sequence:RefSeq:WP_004423638.1
GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA]; GO:0000166 - nucleotide binding [Evidence IEA]
GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498028.1
GO:0004814 - arginine-tRNA ligase activity [Evidence IEA]
GO:0006420 - arginyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498029.1
COORDINATES: similar to AA sequence:RefSeq:WP_000612353.1
COORDINATES: protein motif:HMM:NF020419.2
nucleotidyl transferase AbiEii/AbiGii toxin family protein
COORDINATES: protein motif:HMM:NF012372.2
GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004415337.1
COORDINATES: similar to AA sequence:RefSeq:WP_002880984.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498038.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424863.1
COORDINATES: nucleotide motif:Rfam:14.4:RF00023
Derived by automated computational analysis using gene prediction method: cmsearch.
COORDINATES: similar to AA sequence:RefSeq:WP_002882026.1
GO:0009898 - cytoplasmic side of plasma membrane [Evidence IEA]
GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0015450 - protein-transporting ATPase activity [Evidence IEA]
GO:0043952 - protein transport by the Sec complex [Evidence IEA]
COORDINATES: protein motif:HMM:NF004046.0
GO:0005524 - ATP binding [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498044.1
GO:0008150 - biological_process [Evidence IEA]
YbaB/EbfC family nucleoid-associated protein
COORDINATES: protein motif:HMM:NF025044.2
COORDINATES: similar to AA sequence:RefSeq:WP_004424681.1
GO:0004798 - thymidylate kinase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF024575.2
COORDINATES: similar to AA sequence:RefSeq:WP_002882037.1
GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IEA]
GO:0000451 - rRNA 2'-O-methylation [Evidence IEA]
16S rRNA (cytidine(1402)-2'-O)-methyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_012498049.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0004797 - thymidine kinase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF021546.2
COORDINATES: similar to AA sequence:RefSeq:WP_020002348.1
COORDINATES: similar to AA sequence:RefSeq:WP_014886079.1
GO:0004823 - leucine-tRNA ligase activity [Evidence IEA]
GO:0006429 - leucyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: protein motif:HMM:NF013980.2
COORDINATES: similar to AA sequence:RefSeq:WP_012855393.1
replication-associated recombination protein A
COORDINATES: similar to AA sequence:RefSeq:WP_020002698.1
GO:0009328 - phenylalanine-tRNA ligase complex [Evidence IEA]
GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA]
GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]
phenylalanine--tRNA ligase subunit alpha
COORDINATES: protein motif:HMM:NF001882.0
COORDINATES: protein motif:HMM:NF014517.2
COORDINATES: similar to AA sequence:RefSeq:WP_004423044.1
GO:0008094 - ATP-dependent activity, acting on DNA [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]
GO:0006310 - DNA recombination [Evidence IEA]; GO:0006281 - DNA repair [Evidence IEA]; GO:0009432 - SOS response [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004423041.1
GO:0046872 - metal ion binding [Evidence IEA]; GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881783.1
transcription antitermination protein NusB
COORDINATES: similar to AA sequence:RefSeq:WP_020002694.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002693.1
aminotransferase class V-fold PLP-dependent enzyme
COORDINATES: similar to AA sequence:RefSeq:WP_004423026.1
GO:0005506 - iron ion binding [Evidence IEA]; GO:0051536 - iron-sulfur cluster binding [Evidence IEA]
GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]
iron-sulfur cluster assembly scaffold protein
COORDINATES: protein motif:HMM:NF013015.2
GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]; GO:0000287 - magnesium ion binding [Evidence IEA]
GO:0006281 - DNA repair [Evidence IEA]; GO:0006261 - DNA-templated DNA replication [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881773.1
nicotinate-nucleotide adenylyltransferase
COORDINATES: protein motif:HMM:TIGR00168.2
GO:0003743 - translation initiation factor activity [Evidence IEA]
GO:0006413 - translational initiation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498071.1
COORDINATES: similar to AA sequence:RefSeq:WP_019786714.1
GO:0019843 - rRNA binding [Evidence IEA]; GO:0003735 - structural constituent of ribosome [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498077.1
GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO:0016740 - transferase activity [Evidence IEA]
GO:0008033 - tRNA processing [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004425255.1
GO:0004813 - alanine-tRNA ligase activity [Evidence IEA]
GO:0006419 - alanyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498079.1
GO:0003674 - molecular_function [Evidence IEA]
COORDINATES: protein motif:HMM:NF018633.2
COORDINATES: similar to AA sequence:RefSeq:WP_012498082.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0070063 - RNA polymerase binding [Evidence IEA]
GO:0032784 - regulation of DNA-templated transcription elongation [Evidence IEA]
COORDINATES: nucleotide motif:Rfam:14.4:RF00177
COORDINATES: nucleotide motif:Rfam:14.4:RF02541
COORDINATES: similar to AA sequence:RefSeq:WP_002881205.1
GO:0015934 - large ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881204.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855543.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003899 - DNA-directed 5'-3' RNA polymerase activity [Evidence IEA]; GO:0032549 - ribonucleoside binding [Evidence IEA]
GO:0006351 - DNA-templated transcription [Evidence IEA]
DNA-directed RNA polymerase subunit beta
COORDINATES: similar to AA sequence:RefSeq:WP_012498086.1
GO:0000345 - cytosolic DNA-directed RNA polymerase complex [Evidence IEA]
GO:0003899 - DNA-directed 5'-3' RNA polymerase activity [Evidence IEA]
DNA-directed RNA polymerase subunit beta'
COORDINATES: similar to AA sequence:RefSeq:WP_004424107.1
GO:0008170 - N-methyltransferase activity [Evidence IEA]; GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]; GO:0016430 - tRNA (adenine-N6-)-methyltransferase activity [Evidence IEA]
tRNA1(Val) (adenine(37)-N6)-methyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_020002683.1
GO:0004825 - methionine-tRNA ligase activity [Evidence IEA]
GO:0006431 - methionyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498092.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498094.1
GO:0009294 - DNA-mediated transformation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855609.1
GO:0004731 - purine-nucleoside phosphorylase activity [Evidence IEA]
GO:0043096 - purine nucleobase salvage [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881803.1
GO:0006206 - pyrimidine nucleobase metabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498104.1
GO:0004139 - deoxyribose-phosphate aldolase activity [Evidence IEA]
GO:0009264 - deoxyribonucleotide catabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498105.1
GO:0004845 - uracil phosphoribosyltransferase activity [Evidence IEA]
GO:0009116 - nucleoside metabolic process [Evidence IEA]
rhodanese-like domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_004423072.1
COORDINATES: similar to AA sequence:RefSeq:WP_004423070.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498109.1
GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO:0000312 - plastid small ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498110.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498111.1
GO:0052906 - tRNA (guanine(37)-N(1))-methyltransferase activity [Evidence IEA]
tRNA (guanosine(37)-N1)-methyltransferase TrmD
COORDINATES: similar to AA sequence:RefSeq:WP_020002327.1
COORDINATES: protein motif:HMM:NF022351.2
COORDINATES: similar to AA sequence:RefSeq:WP_012498277.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881189.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855504.1
GO:0003924 - GTPase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855506.1
GO:0016434 - rRNA (cytosine) methyltransferase activity [Evidence IEA]
16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH
COORDINATES: similar to AA sequence:RefSeq:WP_012498124.1
division/cell wall cluster transcriptional repressor MraZ
COORDINATES: similar to AA sequence:RefSeq:WP_020002646.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498130.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498131.1
YebC/PmpR family DNA-binding transcriptional regulator
COORDINATES: protein motif:HMM:TIGR02184.1
COORDINATES: protein motif:HMM:NF012670.2
COORDINATES: similar to AA sequence:RefSeq:WP_002880875.1
COORDINATES: similar to AA sequence:RefSeq:WP_002880873.1
GO:0008795 - NAD+ synthase activity [Evidence IEA]
GO:0009435 - NAD biosynthetic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881053.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855513.1
COORDINATES: similar to AA sequence:RefSeq:WP_002880879.1
GO:0009982 - pseudouridine synthase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002664.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498144.1
GO:0016149 - translation release factor activity, codon specific [Evidence IEA]
GO:0006415 - translational termination [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002662.1
GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IEA]
GO:0018364 - peptidyl-glutamine methylation [Evidence IEA]; GO:0006412 - translation [Evidence IEA]
peptide chain release factor N(5)-glutamine methyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_004424928.1
GO:0006457 - protein folding [Evidence IEA]; GO:0009408 - response to heat [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002660.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity [Evidence IEA]
GO:0006260 - DNA replication [Evidence IEA]; GO:0006265 - DNA topological change [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002880900.1
GO:0004127 - cytidylate kinase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004424937.1
GO:0005525 - GTP binding [Evidence IEA]; GO:0003924 - GTPase activity [Evidence IEA]; GO:0043022 - ribosome binding [Evidence IEA]
GO:0042254 - ribosome biogenesis [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002656.1
GO:0047952 - glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]
GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
COORDINATES: protein motif:HMM:NF012442.2
GO:0030261 - chromosome condensation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498154.1
COORDINATES: protein motif:HMM:NF022525.2
COORDINATES: similar to AA sequence:RefSeq:WP_002880914.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855532.1
helix-turn-helix transcriptional regulator
COORDINATES: similar to AA sequence:RefSeq:WP_012855424.1
COORDINATES: similar to AA sequence:RefSeq:WP_011285383.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424135.1
COORDINATES: protein motif:HMM:NF017911.2
COORDINATES: protein motif:HMM:NF012356.2
GO:0003824 - catalytic activity [Evidence IEA]
GO:0005975 - carbohydrate metabolic process [Evidence IEA]
COORDINATES: protein motif:HMM:NF016116.2
lipoprotein 17-related variable surface protein
COORDINATES: similar to AA sequence:RefSeq:WP_012498166.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498167.1
COORDINATES: protein motif:HMM:NF014679.2
COORDINATES: similar to AA sequence:RefSeq:WP_004425061.1
GO:0004831 - tyrosine-tRNA ligase activity [Evidence IEA]
GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881024.1
alanine/ornithine racemase family PLP-dependent enzyme
COORDINATES: similar to AA sequence:RefSeq:WP_020002329.1
GO:0004126 - cytidine deaminase activity [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence IEA]
GO:0009972 - cytidine deamination [Evidence IEA]
COORDINATES: protein motif:HMM:NF014871.2
GO:0009166 - nucleotide catabolic process [Evidence IEA]
bifunctional UDP-sugar hydrolase/5'-nucleotidase
COORDINATES: protein motif:HMM:NF013250.2
GO:0008444 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [Evidence IEA]
GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_004424821.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855489.1
GO:0004177 - aminopeptidase activity [Evidence IEA]; GO:0046872 - metal ion binding [Evidence IEA]; GO:0070006 - metalloaminopeptidase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF024880.2
GO:0008168 - methyltransferase activity [Evidence IEA]; GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]
COORDINATES: protein motif:HMM:NF012503.2
GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO:0030170 - pyridoxal phosphate binding [Evidence IEA]
GO:0019752 - carboxylic acid metabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498180.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence IEA]
COORDINATES: protein motif:HMM:NF016874.2
COORDINATES: similar to AA sequence:RefSeq:WP_004424514.1
COORDINATES: protein motif:HMM:TIGR01391.1
GO:0003896 - DNA primase activity [Evidence IEA]
GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004424520.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0004820 - glycine-tRNA ligase activity [Evidence IEA]; GO:0000166 - nucleotide binding [Evidence IEA]
GO:0006426 - glycyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002616.1
GO:0048501 - signal recognition particle, plasma membrane targeting [Evidence IEA]
GO:0003924 - GTPase activity [Evidence IEA]; GO:0005048 - signal sequence binding [Evidence IEA]
COORDINATES: protein motif:HMM:TIGR04527.1
GO:0008234 - cysteine-type peptidase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498192.1
GO:0003723 - RNA binding [Evidence IEA]; GO:0008175 - tRNA methyltransferase activity [Evidence IEA]
tRNA (cytidine(34)-2'-O)-methyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_012855497.1
GDSL-type esterase/lipase family protein
COORDINATES: similar to AA sequence:RefSeq:WP_002881056.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498196.1
COORDINATES: protein motif:HMM:NF015714.2
COORDINATES: similar to AA sequence:RefSeq:WP_012498199.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003911 - DNA ligase (NAD+) activity [Evidence IEA]
GO:0006281 - DNA repair [Evidence IEA]; GO:0006260 - DNA replication [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855476.1
energy-coupling factor transporter transmembrane component T
COORDINATES: similar to AA sequence:RefSeq:WP_020002635.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424850.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]
energy-coupling factor transporter ATPase
COORDINATES: similar to AA sequence:RefSeq:WP_020002638.1
GO:0006166 - purine ribonucleoside salvage [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_014886662.1
COORDINATES: protein motif:HMM:NF014881.2
bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase
COORDINATES: similar to AA sequence:RefSeq:WP_002880849.1
COORDINATES: similar to AA sequence:RefSeq:WP_002942223.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855501.1
COORDINATES: similar to AA sequence:RefSeq:WP_002880757.1
16S rRNA (uracil(1498)-N(3))-methyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_012498212.1
Holliday junction branch migration protein RuvA
COORDINATES: similar to AA sequence:RefSeq:WP_004424881.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0009378 - four-way junction helicase activity [Evidence IEA]
Holliday junction branch migration DNA helicase RuvB
COORDINATES: similar to AA sequence:RefSeq:WP_002880864.1
GO:0004821 - histidine-tRNA ligase activity [Evidence IEA]
GO:0006427 - histidyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004424870.1
GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA]; GO:0016874 - ligase activity [Evidence IEA]; GO:0000166 - nucleotide binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855466.1
GO:0005886 - plasma membrane [Evidence IEA]
GO:0015450 - protein-transporting ATPase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855467.1
GO:0008997 - ribonuclease R activity [Evidence IEA]
GO:0006401 - RNA catabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855517.1
triose-phosphate isomerase family protein
COORDINATES: similar to AA sequence:RefSeq:WP_002881061.1
COORDINATES: similar to AA sequence:RefSeq:WP_004425231.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855430.1
GO:0140359 - ABC-type transporter activity [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881068.1
oligopeptide ABC transporter substrate-binding protein
COORDINATES: similar to AA sequence:RefSeq:WP_012855427.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881076.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855547.1
GO:0022625 - cytosolic large ribosomal subunit [Evidence IEA]; GO:0005762 - mitochondrial large ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881078.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003899 - DNA-directed 5'-3' RNA polymerase activity [Evidence IEA]; GO:0046983 - protein dimerization activity [Evidence IEA]
DNA-directed RNA polymerase subunit alpha
COORDINATES: similar to AA sequence:RefSeq:WP_003130556.1
GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855550.1
COORDINATES: similar to AA sequence:RefSeq:WP_020322760.1
COORDINATES: similar to AA sequence:RefSeq:WP_003130554.1
COORDINATES: similar to AA sequence:RefSeq:WP_004416986.1
GO:0036211 - protein modification process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855554.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]
GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002416.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498238.1
frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_018376782.1
incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_004416995.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424382.1
GO:0022625 - cytosolic large ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855560.1
COORDINATES: similar to AA sequence:RefSeq:WP_003948630.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855562.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881104.1
COORDINATES: similar to AA sequence:RefSeq:WP_007073026.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855565.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855566.1
incomplete; partial in the middle of a contig; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_004424359.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498250.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855569.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855570.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855571.1
COORDINATES: protein motif:HMM:NF008919.0
COORDINATES: similar to AA sequence:RefSeq:WP_004424342.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498257.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881133.1
GO:0003723 - RNA binding [Evidence IEA]; GO:0003735 - structural constituent of ribosome [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004417114.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498260.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498262.1
GO:0008324 - monoatomic cation transmembrane transporter activity [Evidence IEA]
GO:0006812 - monoatomic cation transport [Evidence IEA]; GO:0055085 - transmembrane transport [Evidence IEA]
GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]
COORDINATES: protein motif:HMM:NF015531.2
GO:0008236 - serine-type peptidase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002719.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498268.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498276.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498275.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498118.1
COORDINATES: protein motif:HMM:NF013860.2
COORDINATES: protein motif:HMM:TIGR04526.1
putative immunoglobulin-blocking virulence protein
COORDINATES: similar to AA sequence:RefSeq:WP_004424988.1
GO:0016491 - oxidoreductase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002481.1
GO:0008961 - phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity [Evidence IEA]
GO:0009249 - protein lipoylation [Evidence IEA]
prolipoprotein diacylglyceryl transferase
COORDINATES: similar to AA sequence:RefSeq:WP_004424981.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004424125.1
COORDINATES: similar to AA sequence:RefSeq:WP_004424123.1
COORDINATES: protein motif:HMM:NF016109.2
COORDINATES: similar to AA sequence:RefSeq:WP_002880921.1
COORDINATES: protein motif:HMM:NF014680.2
COORDINATES: protein motif:HMM:NF019887.2
COORDINATES: similar to AA sequence:RefSeq:WP_001040566.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002457.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855327.1
COORDINATES: similar to AA sequence:RefSeq:WP_010874785.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0004618 - phosphoglycerate kinase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF015709.2
COORDINATES: similar to AA sequence:RefSeq:WP_020002461.1
GO:0004478 - methionine adenosyltransferase activity [Evidence IEA]
GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498318.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498324.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498312.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498316.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498313.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498308.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498311.1
COORDINATES: protein motif:HMM:NF024487.2
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0004386 - helicase activity [Evidence IEA]; GO:0003676 - nucleic acid binding [Evidence IEA]
COORDINATES: protein motif:HMM:NF014081.2
COORDINATES: protein motif:HMM:NF013421.2
GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002427.1
GO:0004822 - isoleucine-tRNA ligase activity [Evidence IEA]
GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: protein motif:HMM:NF003792.0
GO:0003883 - CTP synthase activity [Evidence IEA]
GO:0006241 - CTP biosynthetic process [Evidence IEA]; GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004025225.1
GO:0046537 - 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity [Evidence IEA]
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
COORDINATES: protein motif:HMM:TIGR03639.1
GO:0004520 - endodeoxyribonuclease activity [Evidence IEA]; GO:0046872 - metal ion binding [Evidence IEA]; GO:0003676 - nucleic acid binding [Evidence IEA]
GO:0051607 - defense response to virus [Evidence IEA]; GO:0043571 - maintenance of CRISPR repeat elements [Evidence IEA]
type II CRISPR-associated endonuclease Cas1
COORDINATES: similar to AA sequence:RefSeq:WP_014574791.1
GO:0004521 - endoribonuclease activity [Evidence IEA]
GO:0043571 - maintenance of CRISPR repeat elements [Evidence IEA]
COORDINATES: protein motif:HMM:NF024108.2
TraM recognition domain-containing protein
COORDINATES: protein motif:HMM:TIGR01865.1
GO:0004520 - endodeoxyribonuclease activity [Evidence IEA]
Cas9, originally named Csn1, is the large, multifunctional signature protein of type II CRISPR/Cas systems. It is well known even to general audiences because its RNA-guided endonuclease activity has made it a popular tool for custom editing of eukaryotic genomes; Derived by automated computational analysis using gene prediction method: Protein Homology.
type II CRISPR RNA-guided endonuclease Cas9
Cas9, originally named Csn1, is the large, multifunctional signature protein of type II CRISPR/Cas systems. It is well known even to general audiences because its RNA-guided endonuclease activity has made it a popular tool for custom editing of eukaryotic genomes; Derived by automated computational analysis using gene prediction method: GeneMarkS-2+.
COORDINATES: nucleotide motif:Rfam:14.4:RF00011
COORDINATES: similar to AA sequence:RefSeq:WP_002881376.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855642.1
GO:0003999 - adenine phosphoribosyltransferase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881654.1
GO:0004222 - metalloendopeptidase activity [Evidence IEA]
COORDINATES: protein motif:HMM:TIGR00594.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498357.1
GO:0003824 - catalytic activity [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]
5'-3' exonuclease H3TH domain-containing protein
COORDINATES: protein motif:HMM:NF018914.2
COORDINATES: similar to AA sequence:RefSeq:WP_012498360.1
GO:0009408 - response to heat [Evidence IEA]
heat-inducible transcriptional repressor HrcA
COORDINATES: protein motif:HMM:NF013212.2
GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IEA]; GO:0051087 - chaperone binding [Evidence IEA]; GO:0042803 - protein homodimerization activity [Evidence IEA]
GO:0006457 - protein folding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004424096.1
GO:0004177 - aminopeptidase activity [Evidence IEA]
GO:0030163 - protein catabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498367.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0004252 - serine-type endopeptidase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881592.1
COORDINATES: similar to AA sequence:RefSeq:WP_004423202.1
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [Evidence IEA]; GO:0005886 - plasma membrane [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855720.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881597.1
spermidine/putrescine ABC transporter substrate-binding protein
COORDINATES: similar to AA sequence:RefSeq:WP_020002584.1
GO:0005525 - GTP binding [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855716.1
GO:0046872 - metal ion binding [Evidence IEA]; GO:0004540 - ribonuclease activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF012869.2
GO:0005524 - ATP binding [Evidence IEA]; GO:0008233 - peptidase activity [Evidence IEA]
cysteine peptidase family C39 domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_012498378.1
GO:0009332 - glutamate-tRNA ligase complex [Evidence IEA]
GO:0004818 - glutamate-tRNA ligase activity [Evidence IEA]
GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855662.1
RpiB/LacA/LacB family sugar-phosphate isomerase
COORDINATES: similar to AA sequence:RefSeq:WP_012855661.1
GO:0003725 - double-stranded RNA binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881423.1
GO:0008534 - oxidized purine nucleobase lesion DNA N-glycosylase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004425384.1
COORDINATES: protein motif:HMM:NF027263.2
type II toxin-antitoxin system RnlB family antitoxin
COORDINATES: protein motif:HMM:NF012304.2
type II toxin-antitoxin system RnlA family toxin
COORDINATES: similar to AA sequence:RefSeq:WP_012498389.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [Evidence IEA]
GO:0006259 - DNA metabolic process [Evidence IEA]; GO:0006265 - DNA topological change [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498391.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498390.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855785.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881651.1
GO:0015297 - antiporter activity [Evidence IEA]; GO:0042910 - xenobiotic transmembrane transporter activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF015448.2
COORDINATES: similar to AA sequence:RefSeq:WP_020002358.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855643.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855362.1
signal recognition particle sRNA small type
COORDINATES: nucleotide motif:Rfam:14.4:RF00169
COORDINATES: protein motif:HMM:NF014442.2
GO:0003677 - DNA binding [Evidence IEA]; GO:0008170 - N-methyltransferase activity [Evidence IEA]
GO:0006306 - DNA methylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004415356.1
GO:0015935 - small ribosomal subunit [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002344.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002345.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855658.1
GO:0008776 - acetate kinase activity [Evidence IEA]
GO:0006083 - acetate metabolic process [Evidence IEA]; GO:0006113 - fermentation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004423984.1
GO:0043937 - regulation of sporulation [Evidence IEA]
COORDINATES: nucleotide motif:Rfam:14.4:RF00001
COORDINATES: similar to AA sequence:RefSeq:WP_012498411.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855664.1
COORDINATES: similar to AA sequence:RefSeq:WP_002882086.1
GO:0003678 - DNA helicase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855666.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002295.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498416.1
ribosome biogenesis GTP-binding protein YihA/YsxC
COORDINATES: similar to AA sequence:RefSeq:WP_004648825.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881791.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498419.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002701.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855387.1
GO:0042586 - peptide deformylase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498423.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855384.1
COORDINATES: similar to AA sequence:RefSeq:WP_002882044.1
GO:0004830 - tryptophan-tRNA ligase activity [Evidence IEA]
GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855382.1
GO:0004829 - threonine-tRNA ligase activity [Evidence IEA]
GO:0006435 - threonyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012855452.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855757.1
GO:0052913 - 16S rRNA (guanine(966)-N(2))-methyltransferase activity [Evidence IEA]
GO:0031167 - rRNA methylation [Evidence IEA]
16S rRNA (guanine(966)-N(2))-methyltransferase RsmD
COORDINATES: similar to AA sequence:RefSeq:WP_012855758.1
GO:0004385 - guanylate kinase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF025053.2
protein phosphatase 2C domain-containing protein
COORDINATES: protein motif:HMM:NF012298.2
GO:0005524 - ATP binding [Evidence IEA]; GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]
GO:0006468 - protein phosphorylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881446.1
GO:0005525 - GTP binding [Evidence IEA]; GO:0043022 - ribosome binding [Evidence IEA]
ribosome small subunit-dependent GTPase A
COORDINATES: similar to AA sequence:RefSeq:WP_020002500.1
GO:0004750 - D-ribulose-phosphate 3-epimerase activity [Evidence IEA]; GO:0046872 - metal ion binding [Evidence IEA]; GO:0016857 - racemase and epimerase activity, acting on carbohydrates and derivatives [Evidence IEA]
GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO:0006098 - pentose-phosphate shunt [Evidence IEA]
COORDINATES: protein motif:HMM:NF021075.2
COORDINATES: similar to AA sequence:RefSeq:WP_012855737.1
GO:0008408 - 3'-5' exonuclease activity [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF013327.2
COORDINATES: similar to AA sequence:RefSeq:WP_012855744.1
COORDINATES: similar to AA sequence:RefSeq:WP_004422979.1
COORDINATES: protein motif:HMM:NF025973.2
GO:0004525 - ribonuclease III activity [Evidence IEA]
GO:0006396 - RNA processing [Evidence IEA]
ribonuclease III domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_004423239.1
GO:0043811 - phosphate:acyl-[acyl carrier protein] acyltransferase activity [Evidence IEA]
GO:0008610 - lipid biosynthetic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881564.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498453.1
GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IEA]; GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO:0070905 - serine binding [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence IEA]
GO:0019264 - glycine biosynthetic process from serine [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498454.1
COORDINATES: protein motif:HMM:NF013222.2
GO:0003677 - DNA binding [Evidence IEA]; GO:0003908 - methylated-DNA-[protein]-cysteine S-methyltransferase activity [Evidence IEA]
methylated-DNA--[protein]-cysteine S-methyltransferase
COORDINATES: similar to AA sequence:RefSeq:WP_012855783.1
GO:0006094 - gluconeogenesis [Evidence IEA]; GO:0019682 - glyceraldehyde-3-phosphate metabolic process [Evidence IEA]; GO:0006096 - glycolytic process [Evidence IEA]
type I glyceraldehyde-3-phosphate dehydrogenase
COORDINATES: similar to AA sequence:RefSeq:WP_004424092.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498458.1
COORDINATES: protein motif:HMM:TIGR00479.1
GO:0008649 - rRNA methyltransferase activity [Evidence IEA]
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD
COORDINATES: similar to AA sequence:RefSeq:WP_012855730.1
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE
COORDINATES: similar to AA sequence:RefSeq:WP_012855766.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855788.1
Tex-like N-terminal domain-containing protein
COORDINATES: protein motif:HMM:TIGR01953.1
GO:0006353 - DNA-templated transcription termination [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002881286.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855795.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855796.1
GO:0019843 - rRNA binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498485.1
GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]
GO:0008033 - tRNA processing [Evidence IEA]; GO:0002098 - tRNA wobble uridine modification [Evidence IEA]
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
COORDINATES: similar to AA sequence:RefSeq:WP_012498486.1
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH
COORDINATES: protein motif:HMM:NF013772.2
COORDINATES: similar to AA sequence:RefSeq:WP_004425323.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002339.1
GO:0009330 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [Evidence IEA]
GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [Evidence IEA]
DNA topoisomerase (ATP-hydrolyzing) subunit B
COORDINATES: similar to AA sequence:RefSeq:WP_012855649.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498495.1
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD
COORDINATES: protein motif:HMM:TIGR03725.1
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB
COORDINATES: similar to AA sequence:RefSeq:WP_012855671.1
GO:0016887 - ATP hydrolysis activity [Evidence IEA]
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE
COORDINATES: similar to AA sequence:RefSeq:WP_012498498.1
GO:0033744 - L-methionine:thioredoxin-disulfide S-oxidoreductase activity [Evidence IEA]; GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IEA]
GO:0030091 - protein repair [Evidence IEA]; GO:0006979 - response to oxidative stress [Evidence IEA]
peptide-methionine (S)-S-oxide reductase MsrA
COORDINATES: similar to AA sequence:RefSeq:WP_004423542.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881458.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881457.1
GO:0004844 - uracil DNA N-glycosylase activity [Evidence IEA]
GO:0006284 - base-excision repair [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004423545.1
GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF014647.2
BMP family ABC transporter substrate-binding protein
COORDINATES: similar to AA sequence:RefSeq:WP_012498506.1
COORDINATES: protein motif:HMM:NF014684.2
COORDINATES: similar to AA sequence:RefSeq:WP_004423664.1
COORDINATES: similar to AA sequence:RefSeq:WP_004425381.1
GO:0008441 - 3'(2'),5'-bisphosphate nucleotidase activity [Evidence IEA]; GO:0004527 - exonuclease activity [Evidence IEA]; GO:0003676 - nucleic acid binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498514.1
bifunctional oligoribonuclease/PAP phosphatase NrnA
COORDINATES: protein motif:HMM:NF015276.2
COORDINATES: similar to AA sequence:RefSeq:WP_020002362.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855352.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855353.1
GO:0008643 - carbohydrate transport [Evidence IEA]; GO:0055085 - transmembrane transport [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_020002594.1
GO:0008237 - metallopeptidase activity [Evidence IEA]; GO:0008270 - zinc ion binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498524.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0004386 - helicase activity [Evidence IEA]
COORDINATES: protein motif:HMM:NF018028.2
COORDINATES: protein motif:HMM:NF012745.2
COORDINATES: similar to AA sequence:RefSeq:WP_012498527.1
GO:0004816 - asparagine-tRNA ligase activity [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA]
GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498528.1
GO:0004828 - serine-tRNA ligase activity [Evidence IEA]
GO:0006434 - seryl-tRNA aminoacylation [Evidence IEA]
COORDINATES: protein motif:HMM:NF024991.2
COORDINATES: similar to AA sequence:RefSeq:WP_012498530.1
GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA]
COORDINATES: protein motif:HMM:TIGR02432.1
GO:0016879 - ligase activity, forming carbon-nitrogen bonds [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498532.1
GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO:0004222 - metalloendopeptidase activity [Evidence IEA]
GO:0051301 - cell division [Evidence IEA]; GO:0006508 - proteolysis [Evidence IEA]
COORDINATES: protein motif:HMM:TIGR00115.1
GO:0005854 - nascent polypeptide-associated complex [Evidence IEA]
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA]; GO:0051082 - unfolded protein binding [Evidence IEA]
GO:0051083 - 'de novo' cotranslational protein folding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004425040.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498535.1
GO:0004634 - phosphopyruvate hydratase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_012498536.1
GO:0004824 - lysine-tRNA ligase activity [Evidence IEA]
GO:0006430 - lysyl-tRNA aminoacylation [Evidence IEA]
COORDINATES: protein motif:HMM:NF024257.2
substrate-binding domain-containing protein
GO:0006817 - phosphate ion transport [Evidence IEA]
phosphate ABC transporter ATP-binding protein
COORDINATES: protein motif:HMM:TIGR02135.1
GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]
GO:0051049 - regulation of transport [Evidence IEA]
phosphate signaling complex protein PhoU
COORDINATES: similar to AA sequence:RefSeq:WP_004423173.1
GO:0008374 - O-acyltransferase activity [Evidence IEA]
GO:0006654 - phosphatidic acid biosynthetic process [Evidence IEA]
glycerol-3-phosphate 1-O-acyltransferase PlsY
COORDINATES: similar to AA sequence:RefSeq:WP_012498542.1
COORDINATES: protein motif:HMM:NF024094.2
COORDINATES: protein motif:HMM:NF012774.2
COORDINATES: similar to AA sequence:RefSeq:WP_004423649.1
COORDINATES: similar to AA sequence:RefSeq:WP_012498547.1
GO:0016990 - arginine deiminase activity [Evidence IEA]
GO:0019546 - arginine deiminase pathway [Evidence IEA]
COORDINATES: protein motif:HMM:NF016146.2
GO:0004518 - nuclease activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002882053.1
ABC-F family ATP-binding cassette domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_012855312.1
COORDINATES: similar to AA sequence:RefSeq:WP_012855802.1
COORDINATES: similar to AA sequence:RefSeq:WP_020002378.1
COORDINATES: similar to AA sequence:RefSeq:WP_002881400.1
GO:0004526 - ribonuclease P activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_004416307.1