Trypanosoma brucei brucei TREU927 chromosome 8, complete sequence.
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma.
The genome of the African trypanosome Trypanosoma brucei
Comparative genomics of trypanosomatid parasitic protozoa
Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8
Submitted (10-APR-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-APR-2005) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP000071.\nChromosome lacks telomere sequences.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
single VAT derivative of TREU (Trypanosomiasis Research Edinburgh University) 927/4 (GPAL/KE/70/EATRO 1534)
variant surface glycoprotein (VSG, pseudogene), putative
expression site-associated gene (ESAG, pseudogene), putative
variant surface glycoprotein (VSG, atypical), putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase (pseudogene), putative
phosphatidic acid phosphatase protein, putative
leucine-rich repeat protein (LRRP, pseudogene), putative
sequence corresponds to BAC RPCI93-12O16
peptide methionine sulfoxide reductase, putative
proteasome regulatory non-ATP-ase subunit 10
identical to GB:AAL72633.1: proteasome regulatory non-ATP-ase subunit 10 {Trypanosoma brucei} (PMID:11854272)
carnitine O-palmitoyltransferase, putative
identical to GB:AAK64280.1: RNA-editing complex protein MP42 {Trypanosoma brucei}(PMID:11564867)
peptidyl-prolyl cis-trans isomerase/rotamase, putative
DNA repair and recombination helicase protein PIF1, putative
This gene is within a region that contains some repeats that are probably misassembled and where Ns were inserted at two locations where misassembly is suspected. See PMID:8663171 for experimental characterization.
nucleolar RNA-binding protein, truncated
This region contains some repeats that are probably misassembled. Ns were inserted at two locations where misassembly is suspected.
This gene is within a region that contains some repeats that are probably misassembled and where Ns were inserted at two locations where misassembly is suspected. See PMID:8663171 for experimental characterization. similar to GB:AAC47134.1: Nopp44/46 {Trypanosoma brucei} (PMID:8663171)
small GTP-binding protein Rab1, putative
98.2 identity to GB:CAB52245.1: splicing factor pTSR1 {Trypanosoma brucei} (PMID:10477180)
ubiquitin-conjugating enzyme E2, putative
This entire sequence corresponds to a 36,265 bp segment of BAC clone RPCI93-25L8.
Number of repeated genes in array uncertain.
Gene within a repeat region, may contain misassembly.
phosphoacetylglucosamine mutase, putative
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase, putative
malonyl-CoA decarboxylase, mitochondrial precursor, putative
hypothetical protein, conserved (pseudogene)
electron transfer flavoprotein-ubiquinone oxidoreductase, putative
Ns indicate region of repeats unresolved within the 5S ribosomal genes cluster. Complete 5S ribosomal genes cluster could be 12 to 18kb long.
acyl-CoA dehydrogenase, mitochondrial precursor, putative
ATP-dependent DEAD/H RNA helicase, putative
procyclin-associated gene (pseudogene), putative
serine/threonine-protein kinase, putative
protein phosphatase 2A, regulatory subunit B, putative
sequence corresponds to BAC RPCI93-26N11
phosphatidylglycerophosphate synthase-like protein, putative
nonspecific lipid-transfer protein, putative
cytochrome c1, heme protein, mitochondrial precursor
endosomal integral membrane protein, putative
cyclophilin type peptidyl-prolyl cis-trans isomerase, putative
mannose-1-phosphate guanyltransferase, putative
vacuolar ATP synthase 16 kDa proteolipid subunit, putative
identical to GP:16304672: multidrug resistance protein A {Trypanosoma brucei brucei}
terbinafine resistance locus protein (yip1), putative
sequence corresponds to BAC RPCI93-26A17
3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative
ribosomal RNA methyltransferase, putative
spliceosomal U5 snRNP-specific protein, putative
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase, putative
ubiquitin-activating enzyme E1, putative
similar to GP:28396150: mitochondrial RNA-binding protein RBP38 {Trypanosoma brucei}(PMID:12796301)
sequence corresponds to BAC RPCI93-28F14
TbRBP10: pers. comm. C. Clayton, University of Heidelberg
acetyl-CoA synthetase (pseudogene), putative
XRNC: pers. comm. C. Clayton, University of Heidelberg
Repetitive protein. Number of repetitive motif uncertain.
mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (pseudogene), putative; Gene within a repeat region that may contain misassembly.
mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative
Gene within a repeat region that may contain misassembly.
similar toGP:12581504: GU1 {Trypanosoma brucei}
Bis(5'-adenosyl)-triphosphatase, putative
cytosolic leucyl aminopeptidase, putative
S-adenosyl-methyltransferase mraW-like protein, putative
t-complex protein 1 gamma subunit, putative
DNA polymerase zeta catalytic subunit, putative
DNA polymerase theta (helicase domain only), putative
glycerol-3-phosphate dehydrogenase [NAD+], glycosomal
similar to SP:Q26756: Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal{Trypanosoma brucei rhodesiense}(PMID:8920003) similar to SP:P90593: Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal (EC 1.1.1.8). {Trypanosoma brucei brucei}(PMID:8920004) similar to GP:1806121: glycerol-3-phosphate dehydrogenase (NAD+) {Leishmania mexicana} (PMID:10743613)
sequence corresponds to BAC RPCI93-10J17
mitogen-activated protein kinase 3, putative
Tandemly repeated. This gene is not in a VSG expression site but its gene product is similar to GP:311494: expression site associated gene {Trypanosoma brucei}.
protein transport protein Sec23, putative
mitogen-activated protein kinase, putative
similar to SP:P00572: Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) {Saccharomyces cerevisiae}
similar to GP:1244788: flagellar glycoprotein {Trypanosoma brucei}
flagellum-adhesion glycoprotein, putative
sequence corresponds to BAC RPCI93-29H22
similar to Wee1-like protein kinase (EC 2.7.1.112). (Swiss-Prot:P47810) [Mus musculus]
similar to GP:11611729: RAB11A GTPase {Trypanosoma brucei}(PMID:14517238)
translation initiation factor eIF-2B beta subunit, putative
similar to GB:CAA68210.1: rab1 {Trypanosoma brucei} (PMID:9099693) Localizes adjacent and posterior to kinetoplast.
small GTP-binding protein Rab7, putative
similar to: GB:CAA68210.1: rab7 {Trypanosoma brucei}(PMID:9099693) Localizes adjacent and posterior to kinetoplast.
flagellar protofilament ribbon protein, putative
Number of repeated genes in array uncertain. May contain five or six units
This gene is within a unresolved repeat region that contains misassembly.
amino acid transporter (pseudogene), putative; This gene is within a unresolved repeat region that contains misassembly.
identical to GB:AAF37004.1: Rab18 {Trypanosoma brucei} (PMID: 11985863)
identical to GB:AAC05496.1: prohibitin {Trypanosoma brucei rhodesiense}(PMID:10200516)
U1 small nuclear ribonucleoprotein, putative
identical to SP:P27727: DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymeraseI). {Trypanosoma brucei brucei}
endoplasmic reticulum oxidoreductin, putative
identical to PIR:S20051: hypothetical protein 1 (pola 5' region) - Trypanosoma brucei brucei {Trypanosoma brucei brucei} (PMID:1754381)
Number of repeated genes in array uncertain. Overlapping BACs RPCI93-4A8 and RPCI93-5H5 contain different number of repeats, three and five, respectively.
similar to SP:P22225: PFR1_TRYBB 69 kDa paraflagellar rod protein (69 kDa PFR protein) (PFR-A/PFR-B). {Trypanosoma brucei brucei} (PMID:2793936) Part of a PFR array. Number of copies uncertain. Overlapping BACs RPCI93-4A8 and RPCI93-25L5 contains different number of repeats, three and five, respectively.
similar to SP:P22225: PFR1_TRYBB 69 kDa paraflagellar rod protein (69 kDa PFR protein) (PFR-A/PFR-B). {Trypanosoma brucei brucei} (PMID:2793936) Part of a PFR array. Number of copies uncertain. Overlapping BACs RPCI93-4A8 and RPCI93-5H5 contains different number of repeats, three and five, respectively.
trafficking protein particle complex subunit 3, putative
DNA-directed RNA polymerase I largest subunit
similar to SP:P16355: RPA1_TRYBB DNA-directed RNA polymerase I largest subunit (EC 2.7.7.6). {Trypanosoma brucei brucei}(PMID:2542092)
identical to GB:AAA30178.1: cytochrome C {Trypanosoma brucei} (PMID:2850466)
cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
similar to cyclophilin A (AAB07896) Trypanosoma brucei brucei.
tyrosyl/methionyl-tRNA synthetase, putative
cell division control protein 2 homolog 4
similar to GB:CAC88354.1: CRK4 protein {Trypanosoma brucei}.
similar to SP:Q26680: FCA2_TRYBB Flagellar calcium-binding protein TB-24 (24 kDa calflagin) (24 kDacalcimedin). {Trypanosoma brucei brucei}(PMID: 7818488)
flagellar calcium-binding protein TB-44A
similar to SP:Q26678: Flagellar calcium-binding protein TB-44A (44 kDa calflagin) (44 kDacalcimedin) {Trypanosoma brucei}(PMID:7818488) Part of an tandem array. Number of copies in the array is uncertain.
sequence corresponds to BAC RPCI93-26E13
apurinic/apyrimidinic endonuclease, putative
Mov34/MPN/PAD-1 metallopeptidase, putative
ubiquitin carboxyl-terminal hydrolase, putative
similarity to PIR:T30519: dihydroorotase (EC 3.5.2.3) - Trypanosoma cruzi {Trypanosoma cruzi} (PMID: 9878395)
recombination initiation protein NBS1, putative
proteasome 26S non-ATPase subunit 9, putative
sequence corresponds to BAC RPCI93-11J15
eukaryotic translation initiation factor 1A, putative
TFIIH basal transcription factor complex helicase subunit, putative
2-amino-3-ketobutyrate coenzyme A ligase, putative
similar to GB:CAB58264.1: ML protein {Trypanosoma brucei} (PMID:10574716)
similar to GB:AAQ01182.1: lysophospholipase {Trypanosoma brucei}
similar to GB:CAD68976.1: inhibitor of cysteine peptidase {Trypanosoma brucei} (PMID:12729889)
DNA repair and transcription factor protein, putative
succinate dehydrogenase flavoprotein, putative
similar to GB:BAA84681.1: succinate dehydrogenase sdhA {Trypanosoma cruzi}
clathrin assembly sigma-adaptin protein 3, putative
ATP-dependent DEAD/H DNA helicase recQ, putative
translationally controlled tumor protein (TCTP), putative
IgE-dependent histamine-releasing factor, putative
similar to GB:AAK29067.1: MLH1 {Trypanosoma brucei} (PMID:14651619)
translation initiation factor IF-2, putative
similar to SP|P55875| Translation initiation factor IF-2 [Stigmatella aurantiaca].
sequence corresponds to BAC RPCI93-10K10
identical to SP:Q08942: Putative serine/threonine-protein kinase A (EC 2.7.1.37). {Trypanosoma brucei brucei}(PMID: 8515773)
dynein light chain 2B, cytoplasmic, putative
3-methylcrotonyl-CoA carboxylase, putative
Gene contains nine 124 bp repeats in tandem, number of repeats uncertain.
Region contains nine 124 bp repeats in tandem, number of repeats uncertain.
serine/threonine-protein kinase A, putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
inositol polyphosphate 1-phosphatase, putative
kinetoplast-associated protein, putative
variant surface glycoprotein (VSG)-related, putative
dihydrolipoamide dehydrogenase, point mutation
serine/threonine protein phosphatase PP1
identical to GB:AAA30229.1: RNA polymerase IIA largest subunit {Trypanosoma brucei} (PMID:2924350)
3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative
Repetitive protein. Number of repetitive motifs uncertain.
tRNA-dihydrouridine synthase 1, putative
receptor-type adenylate cyclase GRESAG 4, putative
Part of a tandem. Number of repeated genes in array uncertain.
amino acid transporter (pseudogene), putative
Ns indicate a gap that contains a tandem repeat. Region was not closed. The tandem size could be 5kb to 9kb.
Ns indicate a physical gap. Region was not closed.
receptor-type adenylate cyclase GRESAG 4 (pseudogene), putative
vacuolar-type proton translocating pyrophosphatase 1
identical to GB:AAK95376.1: vacuolar-type proton translocating pyrophosphatase 1 {Trypanosoma brucei} (PMID:12121996)
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase (pseudogene), putative; Number of tandemly repeated genes in the array is uncertain.
sequence corresponds to BAC RPCI93-28A12
identical to GB:CAC86546.1: amino acid transporter AATP5 {Trypanosoma brucei brucei}
identical to GB:CAC86550.1: amino acid transporter AATP9 {Trypanosoma brucei brucei}
identical to GB:AAG48626.1: cytoskeleton-associated protein CAP5.5 {Trypanosoma brucei}
Gap was not closed. May contain a 1200-1400bp long tandem repeat
mitotic centromere-associated kinesin (MCAK), putative
GO:0007242 - intracellular signaling cascade