Trypanosoma brucei brucei TREU927 chromosome 7, complete sequence.
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma.
The genome of the African trypanosome Trypanosoma brucei
Comparative genomics of trypanosomatid parasitic protozoa
Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8
Submitted (10-APR-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-APR-2005) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP000070.\nChromsome lacks telomere sequences.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
single VAT derivative of TREU (Trypanosomiasis Research Edinburgh University) 927/4 (GPAL/KE/70/EATRO 1534)
variant surface glycoprotein (VSG), putative
variant surface glycoprotein (VSG, pseudogene), putative
expression site-associated gene (ESAG, pseudogene), putative
expression site-associated gene (ESAG) protein, putative
similar to Ribosome biogenesis protein RPF2. (Swiss-Prot:P36160) [Saccharomyces cerevisiae;]
cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
leucine-rich repeat protein (LRRP), putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative : curated by Mike Ferguson.
TbRBP8: pers. comm. C. Clayton, University of Heidelberg
similar to Ring-infected erythrocyte surface antigen (Fragment). (Swiss-Prot:Q26005) [Plasmodium falciparum (isolate PALO ALTO / UGANDA)]
similar to Anoxia up-regulated protein. (Swiss-Prot:Q9VGX3) {Drosophila melanogaster}
similar to Anoxia up-regulated protein. (Swiss-Prot:Q9VGX3) [Drosophila melanogaster]
similar over 232aa to Conserved oligomeric Golgi complex component 7. (Swiss-Prot:P83436) [Homo sapiens]
protein farnesyltransferase beta subunit
similar to Protein farnesyltransferase beta subunit (EC 2.5.1.58) (CAAXfarnesyltransferase beta subunit) (RAS proteins prenyltransferasebeta) (FTase-beta). (Swiss-Prot:P49356) [Homo sapiens]
similar over 69aa to Chaperone protein dnaJ. (Swiss-Prot:P47265) [Mycoplasma genitalium]
similar to Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1). (Swiss-Prot:P36916) [Mus musculus]
similar in zinc finger region to FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1-phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5-kinase) (p235). (Swiss-Prot:Q9Z1T6) [Mus musculus;]; contains Pfam PF01363: FYVE zinc finger
similar to SP:O59855: Probable heat shock protein C1739.13. [Fission yeast] {Schizosaccharomyces pombe}
similar to tRNA pseudouridine synthase C (EC 4.2.1.70) (Pseudouridylate synthase)(Uracil hydrolyase). (Swiss-Prot:Q87MD4) {Vibrio parahaemolyticus}
dynein arm light chain, axonemal, putative
similar to 33 kDa inner dynein arm light chain, axonemal (p33). (Swiss-Prot:Q26630) [Strongylocentrotus purpuratus;]
similar to GB|AAC53043.1|GP|1835784|MMU86137 telomerase protein-1 telomerase-associated protein 1 {Mus musculus}; similar to GB|AAC51107.1|1848277|HSU86136 telomerase-associated protein TP-1 {Homo sapiens}
similar to Putative RNA-binding protein 3 (RNA binding motif protein 3) (RNPL). (Swiss-Prot:P98179) {Homo sapiens}; similar to Glycine-rich RNA-binding protein 7. (Swiss-Prot:Q03250) {Arabidopsis thaliana}
similar to Adrenodoxin homolog, mitochondrial precursor (Mitochondrialferredoxin). (Swiss-Prot:Q12184) [Saccharomyces cerevisiae;]
protein kinase C substrate protein, heavy chain, putative
sequence corresponds to BAC RPCI93-27M11
similar to GB:AAO63565.1: RNA editing complex protein MP100; putative exonuclease {Trypanosoma brucei}(PMID:12649499) Protein identified by mass spectrometry.
similar to DNA repair protein RAD5. (Swiss-Prot:P32849) {Saccharomyces cerevisiae}
trypanothione/tryparedoxin dependent peroxidase 1, cytosolic
identical to GB:CAC83347.1: glutathione peroxidase-like protein gpx1 {Trypanosoma brucei} (PMID: 12466271).
trypanothione/tryparedoxin dependent peroxidase 2
identical to GB:CAC83348.1: glutathione peroxidase-like protein gpx2 {Trypanosoma brucei} (PMID: 12466271).
trypanothione/tryparedoxin dependent peroxidase 3
identical to GB:CAC83349.1: glutathione peroxidase-like protein gpx3 {Trypanosoma brucei} (PMID: 12466271). similar to Probable phospholipid hydroperoxide glutathione peroxidase(EC 1.11.1.9) (PHGPx). (Swiss-Prot:O24031) [Lycopersicon esculentum]
similar along 111aa to RNA-binding protein 8A (RNA binding motif protein 8A)(Ribonucleoprotein RBM8A) (RNA-binding protein Y14) (Binder of OVCA1-1) (BOV-1). (Swiss-Prot:Q9Y5S9) [Homo sapiens]
similar to Glycine-rich RNA-binding protein 10. (Swiss-Prot:Q05966) {Brassica napus}
regulator of chromosome condensation, putative
similar to Regulator of chromosome condensation (Swiss-Prot:P25183) [Xenopus laevis] and to Regulator of chromosome condensation (Cell cycle regulatory protein). (Swiss-Prot:P18754) [Homo sapiens]
similar to GB:AAD08657.1: HERC2 {Homo sapiens}; weakly similar to Regulator of chromosome condensation (PRP20 protein) (Pheromoneresponse pathway component SRM1). (Swiss-Prot:P21827) [Saccharomyces cerevisiae]
similar to Protein disulfide isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72)(ERp72) (Calcium-binding protein 2) (CaBP2). (Swiss-Prot:P38659) [Rattus norvegicus]
spliced leader RNA PSE-promoter transcription factor, putative
similar to GB:AAC48310.1: ATPase subunit 9 homolog {Trypanosoma brucei brucei} Developmentally regulated through the life cycle of Trypanosoma brucei(PMID:9574907); similar to ATP synthase lipid-binding protein, mitochondrial precursor(EC 3.6.3.14) (ATP synthase proteolipid P2) (ATPase protein 9) (ATPasesubunit C). (Swiss-Prot:Q06055) [Homo sapiens]
similar to Nucleotide binding protein 2 (NBP 2). (Swiss-Prot:Q9Y5Y2) [Homo sapiens;]
RNA editing 3' terminal uridylyl transferase 2
identical to GB:AAO63567.1: RNA editing complex protein MP57 {Trypanosoma brucei} (PMID:12820966)
This entire sequence corresponds to a 31,430 bp segment of BAC clone RPCI93-29D18.
similar to GB:AAN77908.2: putative mitotic B-type cyclin CycB3 {Trypanosoma brucei}(PMID:12665514)
C-1-tetrahydrofolate synthase, cytoplasmic, putative
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase, putative
sequence corresponds to BAC RPCI93-29D18
sequence corresponds to BAC RPCI93-43M14
identical to GB:AAC73004.1 and AF102869: Sir2 homolog {Trypanosoma brucei}(PMID:14592982)
eukaryotic peptide chain release factor subunit 1, putative
similar to HIRA-interacting protein 5 (CGI-33). (Swiss-Prot:Q9UMS0) [Homo sapiens;]
adenine phosphoribosyltransferase, putative
similarity to zinc finger region of Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Swiss-Prot:Q13615) [Homo sapiens]
similar over 81 aa in zinc finger region to Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containingdual specificity protein phosphatase 1) (FYVE-DSP1). (Swiss-Prot:Q13615) [Homo sapiens]
RHS array, number of copies uncertain. May contain misassembly.
retrotransposon hot spot (RHS) protein, putative
RHS7: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980). Part of an RHS array that may contain misassembly, number of copies is uncertain.
RHS7: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Part of an RHS array that may contain misassembly, number of copies is uncertain.
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS7: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Part of an RHS array that may contain misassembly, number of copies is uncertain.
RHS7: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family.(PMID: 12455980) Part of an RHS array that may contain misassembly, number of copies is uncertain.
RHS7: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980) Part of an RHS array that may contain misassembly, number of copies is uncertain.
RHS7: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
similar to SP:P40997: mRNA capping enzyme alpha subunit (mRNA guanylyltransferase)(EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase){Schizosaccharomyces pombe}
sequence corresponds to BAC RPCI93-22O10
carnitine O-palmitoyltransferase II, putative
similar to Carnitine O-palmitoyltransferase II, mitochondrial precursor(EC 2.3.1.21) (CPT II). (Swiss-Prot:P23786) [Homo sapiens;]
similar to L-A virus GAG protein N-acetyltransferase (EC 2.3.1.-). (Swiss-Prot:Q03503) [Saccharomyces cerevisiae]
similar to EH-domain containing protein 1 (mPAST1) (Swiss-Prot:Q9WVK4) [Mus musculus]
glycogen synthase kinase-3 alpha, putative
pyrroline-5-carboxylate reductase, putative
similar over 190aa to GTPase-activating protein GYP7 (GAP for YPT7). (Swiss-Prot:P48365) [Saccharomyces cerevisiae]
similar to:GB:AAF91243.1: proteasome regulatory ATPase subunit 1 {Trypanosoma brucei} (PMID:11854272)
endoplasmatic reticulum retrieval protein, putative
ubiquitin-conjugating enzyme E2, putative
identical to GB:AAF91247.1: proteasome regulatory ATPase subunit 5 {Trypanosoma brucei} (PMID:11854272)
sequence corresponds to BAC RPCI93-13M20
similar to NADH-cytochrome b5 reductase precursor (EC 1.6.2.2) (P34/P32). (Swiss-Prot:P36060) [Saccharomyces cerevisiae]
similar to Ligatin (Hepatocellular carcinoma-associated antigen 56). (Swiss-Prot:P41214) [Homo sapiens]
Histone H2 array, number of copies uncertain.
Part of an H2 histone array. Number of copies in the array is uncertain.
similar to Cis,cis-muconate transport protein. (Swiss-Prot:P94131) [Acinetobacter calcoaceticus]
identical to: GB:AAG00461.1: Sm-D1 {Trypanosoma brucei} (PMID:10900267)
identical to GB:AAL85340.1: adaptor medium chain 1 {Trypanosoma brucei}; similar to Adaptor-related protein complex 1, mu 1 subunit (Mu-adaptin 1)(Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1adaptin mu-1 subunit) (Clathrin assembly protein assembly proteincomplex 1 medium chain 1) (Clathrin coat assembly protein AP47)(Clathrin coat associated protein AP47) (AP-mu chain family membermu1A). (Swiss-Prot:P35585) {Mus musculus}
sequence corresponds to BAC RPCI93-28B13
translation initiation factor IF-2, putative
microtubule-associated protein 1A/1B, light chain 3, putative
similar to GB:AAO17735.1: farnesyl pyrophosphate synthase {Trypanosoma brucei} (PMID:12618430)
similar to GB:AAL01153.1: centrin {Leishmania donovani}(PMID:11544261)
peptidyl-prolyl cis-trans isomerase, putative
similar to FK506-binding protein 1 (FKBP) (Peptidyl-prolyl cis-trans isomerase)(PPIase) (EC 5.2.1.8) (Rapamycin-binding protein). (Swiss-Prot:P20081) [Saccharomyces cerevisiae]
similar to GB:AAF89277.1: cyclophilin {Trypanosoma cruzi} (PMID:1141034)
similar to SP:Q26768: I/6 autoantigen. {Trypanosoma brucei brucei} (PMID=9127738)
synaptojanin (N-terminal domain), putative
glutathione-S-transferase/glutaredoxin, putative
similar to Neurofilament triplet H protein (200 kDa neurofilament protein)(Neurofilament heavy polypeptide) (NF-H). (Swiss-Prot:P12036) {Homo sapiens}
TPR-repeat-containing chaperone protein DNAJ, putative
similar to DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2)(TPR repeat protein 2). (Swiss-Prot:Q99615) [Homo sapiens]
ubiquitin/ribosomal protein S27a, putative
similar to GB:AAP42139.1: RNA-binding protein UBP-1 {Trypanosoma cruzi} (PMID:12637517); similar to Cleavage stimulation factor, 64 kDa subunit (CSTF 64 kDa subunit)(CF-1 64 kDa subunit). (Swiss-Prot:P33240) [Homo sapiens;]
Repetitive protein. Number of repetitive motif uncertain.
Repetitive protein. Number of repetitive motif uncertain. This gene is within a region of repeats and might be misassembled.
kinesin-like protein, fragment, putative
This gene is within a region of repeats and might be misassembled.
vacuolar transporter chaperone, putative
RNA editing 3' terminal uridylyl transferase 1
identical to GB:AAK38334.1 3' terminal uridylyl transferase {Trypanosoma brucei} (PMID:11893335)
identical to GB:CAB91831.1: possible ribosomal protein {Leishmania major}
mitochondrial DNA polymerase I protein C
identical to: GB:AAM81964.1: DNA polymerase I-like protein C {Trypanosoma brucei}(PMID:12150917)
similar to Protein phosphatase 2C (EC 3.1.3.16) (PP2C). (Swiss-Prot:P49444) [Paramecium tetraurelia]
calpain-like cysteine peptidase, putative
similar to DNA excision repair protein ERCC-6 (Cockayne syndrome protein CSB). (Swiss-Prot:Q03468) [Homo sapiens]
serine/threonine-protein kinase, putative
Repeat region unresolved, may contain misassembly.
Part of an unresolved repeat region, may contain misassembly.
sequence corresponds to BAC RPCI93-26A24
inositol polyphosphate kinase-like protein, putative
similar to GP:11066269: 20S proteasome alpha 3 subunit {Trypanosoma brucei} (PMID:11309374)
adenosine 5'-monophosphoramidase, putative
similar to SP:O07513: Hit protein. {Bacillus subtilis}
similar to Sorting nexin 4. (Swiss-Prot:P47057) {Saccharomyces cerevisiae}
similar to DNA repair protein rhp54 (RAD54 homolog 1). (Swiss-Prot:P41410) [Schizosaccharomyces pombe]
identical to GP:14250901: Rrp4p homologue {Trypanosoma brucei} (PMID:11447124)
pumilio/PUF RNA binding protein 5, putative
PUF5 : personnal communication (Van-Duc Luu and Christine Clayton, University of Heidelberg)
identical to GP:6224687: 20S proteasome beta 6 subunit {Trypanosoma brucei brucei}(PMID: 11309374)
similar to SAM domain and HD domain-containing protein 1 (Dendritic cell-derivedIFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5). (Swiss-Prot:Q9Y3Z3) [Homo sapiens;]
XRNA: pers. comm. C. Clayton, University of Heidelberg; similar to Exonuclease II (EC 3.1.11.-) (Exo II) (P140) (Swiss-Prot:P40383) [Schizosaccharomyces pombe]
identical to GP:2114394: ribonuclease H1 {Trypanosoma brucei}EGAD|141244|150614 ribonuclease H1 {Trypanosoma brucei} (PMID:9178276)
similar to Protease II (EC 3.4.21.83) (Oligopeptidase B). (Swiss-Prot:Q59536) [Moraxella lacunata]
NAD(p)-dependent steroid dehydrogenase-like protein
similar to SP:Q15738: NAD(P)-dependent steroid dehydrogenase (EC 1.1.1.-) {Homo sapiens}
sequence corresponds to BAC RPCI93-27E10
similar to SP:P41165: 60S ribosomal protein L23A (L25). {Trypanosoma brucei brucei} (PMID:8177742)
similar to GP:11023151: lanosterol synthase {Trypanosoma brucei brucei} (PMID:11071292)
sequence corresponds to BAC RPCI93-10C21
similar to SP:O64380: Polyadenylate-binding protein 3 (Poly(A)-binding protein 3) (PABP 3). {Arabidopsis thaliana}
dihydrofolate reductase-thymidylate synthase
similar to SP:Q27783: Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. {Trypanosoma brucei brucei}(PMID:8538681)
similar to SP:Q99MI9: Protein arginine N-methyltransferase (EC 2.1.1.-). {Cricetulus longicaudatus}
glucosamine-fructose-6-phosphate aminotransferase, putative
cell cycle associated protein MOB1, putative
identical to GP:15983733 cell cycle associated protein Mob1-1 {Trypanosoma brucei}
similar to GP:15983735: cell cycle associated protein Mob1-2 {Trypanosoma brucei}
similar to SP:Q9RBS2: PopC protein. [Pseudomonas solanacearum] {Ralstonia solanacearum}
deoxyribose-phosphate aldolase, putative
nuclear transport factor 2 protein, putative
similar to NTF2-related export protein (p15). (Swiss-Prot:Q9V3H8) [Drosophila melanogaster]
similar to GP:6048279: protein kinase {Trypanosoma brucei}
similarity to GP:26518518: protein disulfide isomerase {Leishmania donovani}(PMID:12427741)
similar to Protein visC (EC 1.-.-.-). (Swiss-Prot:P25535) [Escherichia coli]
mercaptopyruvate sulfurtransferase, putative
Number of repeated genes in array uncertain, region may contain misassembly. similar to GB:CAC85742.1: mercaptopyruvate sulfurtransferase {Leishmania mexicana}; similar to 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) (Rhodanese-likeprotein) (MST) (Swiss-Prot:P31142) [Escherichia coli]
Number of repeated genes in array uncertain, region may contain misassembly.
receptor-type adenylate cyclase GRESAG 4, putative
Number of repeated genes in array uncertain, region may contain misassembly. similar to GB:CAD21883.1: ESAG4 {Trypanosoma brucei}
Number of repeated genes in array uncertain, region may contain misassembly; similar to GB:CAD21877.1: ESAG4 {Trypanosoma brucei}
similar to Peptidase T-like protein YPO1009/Y3403 (EC 3.4.11.-). (Swiss-Prot:Q8ZH96) [Yersinia pestis]; similar to Peptidase T (EC 3.4.11.14) (Tripeptide aminopeptidase)(Aminotripeptidase) (Tripeptidase). (Swiss-Prot:P55179) [Bacillus subtilis]
similar to SP:P53350: Serine/threonine-protein kinase PLK (EC 2.7.1.-) (PLK-1) (Serine- threonine protein kinase 13) (STPK13){Homo sapiens} identical to GP:2644989: polo-like protein kinase {Trypanosoma brucei} (PMID:9511745)
sequence corresponds to BAC RPCI93-33N13
NADH-ubiquinone oxidoreductase, mitochondrial, putative
identical to GB|AY551260 Trypanosoma brucei Lsm2p (Lsm2) gene {Trypanosoma brucei}
tRNA-dihydrouridine synthase 3, putative
similar to tRNA-dihydrouridine synthase 3 (EC 1.-.-.-) (Swiss-Prot:Q06053) [Saccharomyces cerevisiae]
O-sialoglycoprotein endopeptidase, putative
sequence corresponds to BAC RPCI93-15M23
variant surface glycoprotein (VSG, atypical), putative
similar to Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.1.-)(MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2). (Swiss-Prot:Q61083) [Mus musculus]
similar over 436aa to GB:AAN72135.1: protein phosphatase 2A 62 kDa B regulatory subunit {Arabidopsis thaliana}
sequence corresponds to BAC RPCI93-25D22
similar to GB:AAG32055.1: putative trans-sialidase B38p {Trypanosoma brucei}(PMID:12071958)
Ns indicate a sequencing hard stop within a polyC region.
sequence corresponds to BAC RPCI93-21H15
double-strand-break repair protein rad21 homolog, putative
methylthioadenosine phosphorylase, putative
dual specificity protein phosphatase, putative
sequence corresponds to BAC RPCI93-30D13
ATP-dependent DEAD/H RNA helicase, putative
identical to SP|P23394| Pre-mRNA splicing factor RNA helicase PRP28 (Helicase CA8) {Saccharomyces cerevisiae} (PMID:7520570)
cell division control protein 2 homolog 2
identical to SP|P54665| Cell division control protein 2 homolog 2 (EC 2.7.1.37) {Trypanosoma brucei brucei} (PMID:7557404)
U6 snRNA-associated Sm-like protein LSm3p
identical to GB:AAS57925.1: Lsm3p {Trypanosoma brucei} (PMID:14990572)
Repetitive protein. Number of repetitive motifs uncertain.
ATP synthase alpha chain, mitochondrial precursor
similar to GB:AAG23339.1: ATPase alpha subunit {Trypanosoma brucei brucei} (PMID:11295183)
similar to Autoantigen NGP-1 (Swiss-Prot:Q13823) [Homo sapiens]; similar to GB:CAC32261.1: MMR_HSR1 GTP-binding protein {Leishmania major}
similar to GB:AAG09432.1: TSI1p {Trypanosoma brucei}; similar to 85 kDa surface antigen precursor. (Swiss-Prot:Q03877) [Trypanosoma cruzi]
Presents weak similarities with Nterm part of putative adenylate cyclase regulatory proteins (putative expression-site associated proteins 8 ESAG8)
iron/ascorbate oxidoreductase family protein, putative
leucine-rich repeat protein (LRRP, pseudogene), putative