Trypanosoma brucei brucei TREU927 chromosome 6, complete sequence.
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma.
The genome of the African trypanosome Trypanosoma brucei
Comparative genomics of trypanosomatid parasitic protozoa
Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8
Submitted (10-APR-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-APR-2005) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP000069.\nChromosome lacks telomere sequences.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
single VAT derivative of TREU (Trypanosomiasis Research Edinburgh University) 927/4 (GPAL/KE/70/EATRO 1534)
sequence corresponds to BAC RPCI93-26F19
receptor-type adenylate cyclase GRESAG 4 (pseudogene), putative
leucine-rich repeat protein (LRRP, pseudogene), putative
retrotransposon hot spot (RHS) protein, putative
RHS5: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS3. Chimeric gene between RHS2 (N-terminal domain) and RHS3 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
RHS1. Chimeric gene between RHS5 (N-terminal domain) and RHS1 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
receptor-type adenylate cyclase GRESAG 4, putative
similar to SP:Q99279: Receptor-type adenylate cyclase GRESAG 4.1 (EC 4.6.1.1) (ATPpyrophosphate-lyase) (Adenylyl cyclase). {Trypanosoma brucei brucei}
Region contains 49bp-repeats in tandem. Number of repeats in the array could be 100 to 200.
sequence corresponds to BAC RPCI93-28F21
similarity to GP:5565973: adenosine transporter 1 {Trypanosoma brucei}(PMID:10514517)
expression site-associated gene (ESAG, pseudogene), putative
similar to GB:CAD21877.1: ESAG4 {Trypanosoma brucei}
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase (pseudogene), putative
similar to SP:P08469: Procyclic form specific polypeptide B1-alpha precursor (Procyclin B1- alpha) (PARP). {Trypanosoma brucei brucei}
similar to GP:535936: procyclin PARP A {Trypanosoma brucei}
gene related to expression site-associated gene 2 (GRESAG2), putative
similar to PIR:B39685: GRESAG protein 2.1-2 {Trypanosoma brucei}
similar to GP:29469418: procyclin EP2 {Trypanosoma evansi}; similar to SP:P09791: Procyclic form specific polypeptide A-beta precursor (Procyclin) (PARP A-beta) {Trypanosoma brucei brucei}
similar to GP:535936: procyclin PARP A {Trypanosoma brucei} (PMID:87115776)
similar to GB:CAD21888.1: ESAG2 {Trypanosoma brucei}
similar to SP:P18764: Procyclic form specific polypeptide A-alpha precursor (Procyclin A- alpha) (PARP A-alpha). {Trypanosoma brucei brucei}
identical to GP:14485024: surface protein EP3-3 procyclin precursor {Trypanosoma brucei brucei}; identical to SP:P09791: Procyclic form specific polypeptide A-beta precursor (Procyclin) (PARP A-beta)(Trypanosoma brucei brucei)
similar to SP:Q60809: CCR4-NOT transcription complex, subunit 7 (CCR4-associated factor 1)(CAF1). {Mus musculus}
serine/threonine protein phosphatase, putative
identical to GB:CAC39260.1: Rrp45p homologue {Trypanosoma brucei}; similar to Exosome complex exonuclease RRP45 (EC 3.1.13.-) (Ribosomal RNAprocessing protein 45). (Swiss-Prot:Q05636) [Saccharomyces cerevisiae]
ATP-dependent DEAH-box RNA helicase, putative
similar to ATP-dependent RNA helicase A (Nuclear DNA helicase II) (NDH II)(DEAH-box protein 9) (mHEL-5) (Swiss-Prot:O70133) [Mus musculus]
pumilio/PUF RNA binding protein 4, putative
PUF4 : personnal communication (Van-Duc Luu and Christine Clayton, University of Heidelberg)
similar to GP:19032268: metacaspase {Trypanosoma brucei}(PMID:12062425)
identical to SP:P14658: Cysteine proteinase precursor (EC 3.4.22.-). {Trypanosoma brucei brucei}
identical to SP:P14658: Cysteine proteinase precursor (EC 3.4.22.-). {Trypanosoma brucei brucei} PMID:2651912
hydroxyacylglutathione hydrolase, putative
similar to Hydroxyacylglutathione hydrolase cytoplasmic (EC 3.1.2.6) (GlyoxalaseII) (Glx II). (Swiss-Prot:O24496) [Arabidopsis thaliana;]
similar to 26S protease regulatory subunit 6B (ATPase MS73). (Swiss-Prot:P46507) [Manduca sexta;]
ubiquitin carboxyl-terminal hydrolase, putative
similar to Probable mannosyltransferase ALG9 (EC 2.4.1.-). (Swiss-Prot:P53868) [Saccharomyces cerevisiae;]
similar to GP:4633066: protein phosphatase-1 regulatory subunit 7 alpha2 {Homo sapiens}
similar to GP:4218582: proteasome beta-1 subunit {Trypanosoma brucei rhodesiense}(PMID:10498178)
translation initiation factor eIF-2B alpha subunit, putative
similar to Translation initiation factor eIF-2B alpha subunit (eIF-2B GDP-GTP exchange factor). (Swiss-Prot:Q64270) [Rattus norvegicus]
cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
similar to Piccolo protein (Aczonin). (Swiss-Prot:Q9Y6V0) [Homo sapiens]; similar to Piccolo protein (Presynaptic cytomatrix protein) (Aczonin) (Brain-derived HLMN protein). (Swiss-Prot:Q9QYX7) [Mus musculus;]
similar to Wiskott-Aldrich syndrome protein homolog (WASp). (Swiss-Prot:P70315) [Mus musculus;]
identical to:GB:CAB82895.1: cyclin {Trypanosoma brucei} (PMID:10722661)
sequence corresponds to BAC RPCI93-28P18
similar to internalin H (GI:3980135) [Listeria monocytogenes]
alkyl-dihydroxyacetone phosphate synthase
identical to SP:O97157: Alkyldihydroxyacetonephosphate synthase (EC 2.5.1.26) (Alkyl-DHAP synthase) (Alkylglycerone-phosphate synthase). {Trypanosoma brucei brucei}(PMID:10589981)
similar to Aquaporin 3 (31.4 kDa water channel protein) (Swiss-Prot:P47862) [Rattus norvegicus]
similar to Extensin precursor (Proline-rich glycoprotein). (Swiss-Prot:P14918) {Zea mays}; contains Pfam PF04893: Yip1 domain.
2-hydroxy-3-oxopropionate reductase, putative
polynucleotide kinase 3'-phosphatase, putative
ribosomal RNA adenine dimethylase family protein, conserved
similar to Dimethyladenosine transferase (EC 2.1.1.-) (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (Kasugamycindimethyltransferase) (SP:Q92GV0) {Rickettsia conorii}; similar to Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (Swiss-Prot:Q9D0D4) {Mus musculus}
single strand-specific nuclease, putative
ubiquitin hydrolase (pseudogene), putative
AUT2/APG4/ATG4 cysteine peptidase, putative
similar to GP:16116698: KU80 protein {Trypanosoma brucei} (PMID:11919193)
mitogen-activated protein kinase, putative
similar to SP:P36982: Protein phosphatase 2C (EC 3.1.3.16) (PP2C). {Leishmania donovani chagasi}
similar to Dolichyldiphosphatase (EC 3.6.1.43) (Dolichyl pyrophosphatephosphatase). (Swiss-Prot:P53223) [Saccharomyces cerevisiae;]
eukaryotic translation initiation factor 4E, putative
similar to Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNAcap-binding protein) (eIF-4F 25 kDa subunit). (Swiss-Prot:Q9P974) [Candida glabrata;]
similar to SP:P14868: Aspartyl-tRNA synthetase (EC 6.1.1.12) (Aspartate--tRNA ligase)(AspRS). {Homo sapiens}
similar to outer arm dynein light chain 2 (GI:2760161) [Anthocidaris crassispina]
glycosyltransferase family 28 protein, putative
similar to 20 kDa nuclear cap binding protein (NCBP 20 kDa subunit) (CBP20) (NCBPinteracting protein 1) (NIP1). (Swiss-Prot:P52298) {Homo sapiens}
spliceosome-associated protein, putative
similar to Nitrate reductase (EC 1.7.1.1) (NR). (Swiss-Prot:P23312) [Spinacia oleracea;]
ribosome biogenesis regulatory protein (RRS1), putative
cell division cycle protein 16, putative
similar to Vacuolar protein 8. (Swiss-Prot:P39968) [Saccharomyces cerevisiae]
similar to GP:4741688: hypothetical protein {Trypanosoma brucei brucei}(PMID:9705321)
similar to GB:AAC80288.1: adenosine kinase {Leishmania donovani}
similar to Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (h76p) (Hgrip76). (Swiss-Prot:Q9UGJ1) [Homo sapiens;]
ubiquitin fusion degradation protein 2, putative
similar to Ubiquitin conjugation factor E4 (Ubiquitin fusion degradation protein2) (UB fusion protein 2). (Swiss-Prot:Q9HE05) {Schizosaccharomyces pombe}
similar to SP:P31483: Nucleolysin TIA-1 (RNA-binding protein TIA-1) (p40-TIA-1) [Contains:Nucleolysin TIA-1 isoform p15 (p15-TIA-1)]. {Homo sapiens}
similar to Importin alpha-1 subunit (Karyopherin alpha-1 subunit) (KAP alpha). (Swiss-Prot:Q96321) [Arabidopsis thaliana;]
identical to GP:9837178: Sm-E {Trypanosoma brucei}(PMID:10900267)
identical to GB:AAC61803.1: pyridoxine/pyridoxal/pyridoxamine kinase {Trypanosoma brucei} (PMID:9274862)
vacuolar assembly protein vps41, putative
U3 small nuclear ribonucleoprotein (snRNP), putative
similar to GB:AAD14602.1: stage specific peptide 24 {Trypanosoma cruzi}; similar to U3 small nucleolar ribonucleoprotein protein IMP4. (Swiss-Prot:P53941) [Saccharomyces cerevisiae]
identical to GB:CAB46088.2: ESAG8-associated protein {Trypanosoma brucei brucei} (PMID:10413051)
similar to SAM domain and HD domain-containing protein 1 (Dendritic cell-derivedIFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5). (Swiss-Prot:Q9Y3Z3) [Homo sapiens]
similar to Ribosomal large subunit pseudouridine synthase A (EC 4.2.1.70)(Pseudouridylate synthase) (Uracil hydrolyase). (Swiss-Prot:P39219) {Escherichia coli;Shigella flexneri}
similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunitof AP-4) (AP-4 adapter complex epsilon subunit). (Swiss-Prot:Q9UPM8) [Homo sapiens;]
pseudouridine synthase A-like protein, putative
similar to Eukaryotic translation initiation factor 2 alpha kinase 1(EC 2.7.1.37) (Heme-regulated eukaryotic initiation factor eIF-2-alphakinase) (Heme-regulated inhibitor) (Heme-controlled repressor)(HCR) (Hemin-sensitive initiation factor-2 alpha kinase) (PRO1362). (Swiss-Prot:Q9BQI3) [Homo sapiens]
small GTP-binding protein Rab28, putative
similar to GP:20379086: small GTP binding protein RAB28 {Homo sapiens}
similar to Aldehyde dehydrogenase (EC 1.2.1.3). (Swiss-Prot:P12693) [Pseudomonas oleovorans]
queuine tRNA-ribosyltransferase, putative
similar to Ribosomal large subunit pseudouridine synthase A (EC 4.2.1.70)(Pseudouridylate synthase) (Uracil hydrolyase). (Swiss-Prot:Q8Z9J5) {Salmonella typhi}
intraflagellar transport (IFT) protein, putative
calpain-like cysteine peptidase, putative
ferric reductase transmembrane protein, putative
retrotransposon hot spot protein (RHS, pseudogene), putative
similar over 485aa to Polyadenylate-binding protein 3 (Poly(A)-binding protein 3) (PABP 3). (Swiss-Prot:O64380) [Arabidopsis thaliana;]
identical to GB:AAL14124.1: ZFP1 {Trypanosoma brucei rhodesiense} (PMID:11726506)
endosomal trafficking protein RME-8, putative
phospholipid-translocating P-type ATPase (flippase), putative
tubulin-tyrosine ligase-like protein, conserved
similar to Tubulin tyrosine ligase-like protein 1. (Swiss-Prot:O95922) [Homo sapiens;]
ATP-dependent DEAD/H DNA helicase recQ, putative
sphingosine phosphate lyase-like protein, putative
similar to GP:1262824: ADP-ribosylation factor-like protein {Leishmania tarentolae}
pre-mRNA cleavage complex II Clp1-like, conserved
heat shock 70 kDa protein, mitochondrial precursor, putative
valosin-containing protein homolog, putative
similar to GB:AAC02215: valosin-containing protein homolog {Trypanosoma brucei}; similar to SAV protein. (Swiss-Prot:Q07590) {Sulfolobus acidocaldarius}; similar to SP:Q58556: Cell division cycle protein 48 homolog MJ1156. {Methanocaldococcus jannaschii}
TbRBP14: pers. comm. C. Clayton, University of Heidelberg similar to Putative RNA-binding protein 3 (RNA binding motif protein 3). (Swiss-Prot:O89086) {Mus musculus}
replication factor C, subunit 2, putative
chaperonin Hsp60, mitochondrial precursor, putative
similar to SP:Q37683: Chaperonin HSP60, mitochondrial precursor (Protein Cpn60) (groELprotein) (Heat shock protein 60). {Trypanosoma brucei brucei}
similar to Trichohyalin. (Swiss-Prot:Q07283) {Homo sapiens}
similar to Aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase). (Swiss-Prot:Q27640) [Enchytraeus buchholzi]; similar to Aldehyde dehydrogenase 1A1 (EC 1.2.1.3) (Aldehyde dehydrogenase,cytosolic) (ALDH class 1) (Retinal dehydrogenase 1) (ALHDII)(ALDH-E1). (Swiss-Prot:P00352) [Homo sapiens]
mitogen-activated protein kinase 5, putative
glyceraldehyde 3-phosphate dehydrogenase, glycosomal
identical to SP:P22512: Glyceraldehyde 3-phosphate dehydrogenase, glycosomal (EC 1.2.1.12)(GAPDH). {Trypanosoma brucei brucei}
hypothetical protein, conserved (pseudogene)
longer than, but otherwise identical to SP:P22512: Glyceraldehyde 3-phosphate dehydrogenase, glycosomal (EC 1.2.1.12)(GAPDH). {Trypanosoma brucei brucei}
U6 snRNA-associated Sm-like protein LSm5p
identical to GB| AY551263 Trypanosoma brucei Lsm5p {Trypanosoma brucei}(PMID:14990572)
ribosomal RNA assembly protein, putative
similar to Ribosomal RNA assembly protein mis3. (Swiss-Prot:O74777) [Schizosaccharomyces pombe;]
eukaryotic translation initiation factor 3 subunit 7-like protein
S-adenosylmethionine decarboxylase proenzyme, putative
similar to Homoserine kinase (EC 2.7.1.39) (HK). (Swiss-Prot:Q10603) [Mycobacterium bovis;Mycobacterium tuberculosis]
S-adenosylmethionine decarboxylase proenzyme-like, putative
similar to Valyl-tRNA synthetase 2 (EC 6.1.1.9) (Valine--tRNA ligase 2) (ValRS 2)(G7a). (Swiss-Prot:P26640) [Homo sapiens;]
3-hydroxy-3-methylglutaryl-CoA reductase, putative
pre-mRNA splicing factor ATP-dependent RNA helicase, putative
similar to ATP-dependent helicase DHX8 (RNA helicase HRH1) (DEAH-box protein 8) (Swiss-Prot:Q14562) [Homo sapiens]
UV excision repair RAD23 protein, putative
similar to UV excision repair protein rhp23 (RAD23 homolog). (Swiss-Prot:O74803) {Schizosaccharomyces pombe}
cationic amino acid transporter, putative
similar to High-affinity cationic amino acid transporter-1 (CAT-1) (CAT1) (SystemY+ basic amino acid transporter) (Ecotropic retroviral leukemiareceptor) (ERR) (Ecotropic retrovirus receptor). (Swiss-Prot:P30823) [Rattus norvegicus]
importin-alpha re-exporter protein, putative
similar to Importin-alpha re-exporter (Chromosome segregation 1-like protein)(Cellular apoptosis susceptibility protein) (Swiss-Prot:Q9PTU3) [Pagrus major]
sequence corresponds to BAC RPCI93-30P15
similar to Drosophila Yippee protein, a putative zinc binding protein. {Drosophila melanogaster} (PMID: 11240639)
similar to GP:20387267: LORIEN nucleoprotein {Leishmania infantum}(PMID:1698393); similar to Protein inhibitor of activated STAT protein gamma (PIAS-gamma)(PIASy). (Swiss-Prot:Q9JM05) [Mus musculus;]
S-adenosylmethionine synthetase, putative
serine/arginine-rich protein specific kinase SRPK, putative
identical to SP:P19800: 40S ribosomal protein S14. {Trypanosoma brucei brucei} (PMID:2188114)
identical to GP|26324282|:putative G1 cyclin CycE2 [Trypanosoma brucei](PMID:12665514)
similar to Vacuolar ATP synthase 21 kDa proteolipid subunit (EC 3.6.3.14)(HATPL). (Swiss-Prot:Q99437) [Homo sapiens]
serine/threonine-protein kinase, putative
damage-specific DNA binding protein, putative
60S acidic ribosomal protein P2, putative
similar to SP:P51408: 60S acidic ribosomal protein P2. {Trypanosoma brucei brucei}
ribosomal P protein AGP2beta-1, putative
identical to GP:436143: AGP2beta-1 {Trypanosoma cruzi} (PMID:10548722)
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS3, point mutation: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS4, interrupted by an ingi retrotransposon and a RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS4, interrupted by an ingi retrotransposon and a RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
DNA-directed RNA polymerase III (pseudogene), putative
variant surface glycoprotein (VSG, pseudogene), putative
variant surface glycoprotein (VSG, atypical), putative
variant surface glycoprotein (VSG), putative
This Tn10 insertion is an artefact from the BAC construction and is not present in other BACs covering this region or in Tb927 genomic DNA.
The Tn10 insertion is an artefact from the BAC construction and is not present in other BACs covering this region or in Tb927 genomic DNA.