Trypanosoma brucei brucei TREU927 chromosome 5, complete sequence.
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma.
The genome of the African trypanosome Trypanosoma brucei
Comparative genomics of trypanosomatid parasitic protozoa
Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8
Submitted (10-APR-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-APR-2005) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP000068.\nChromosome lacks telomere sequences.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
single VAT derivative of TREU (Trypanosomiasis Research Edinburgh University) 927/4 (GPAL/KE/70/EATRO 1534)
sequence corresponds to BAC RPCI93-25N21
expression site-associated gene (ESAG, pseudogene), putative
variant surface glycoprotein (VSG)-related, putative
VSG-related: pers. comm. Dave Barry (University of Glasgow, UK)
expression site-associated gene (ESAG) protein, putative
similar to GB:CAD53280.1: ESAG9 (expression site-associated gene 9) protein, possible {Trypanosoma brucei}
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
variant surface glycoprotein (VSG, pseudogene), putative
variant surface glycoprotein (VSG, atypical), putative
variant surface glycoprotein (VSG, pseudogene), putative; The gene was interrupted by INGI insertion.
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS3, interrupted by an ingi retrotransposon. Additionnal truncation in N-terminal. The C-terminal domain was probably lost. pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
iron/ascorbate oxidoreductase family protein, putative
similar to GB:AAO54300.1: oxidoreductase, 2OG-Fe(II) oxygenase family {Pseudomonas syringae pv. tomato str. DC300}.
receptor-type adenylate cyclase GRESAG 4, putative
similar to GB:CAA36364.1: putative adenyl/guanylyl cyclase {Trypanosoma brucei} (PMID:1982555)
similar to Lipopolysaccharide-binding protein precursor (LBP). (Swiss-Prot:P18428) {Homo sapiens}; similar to GB:CAD21459.1: ESAG5 {Trypanosoma brucei}
75 kDa invariant surface glycoprotein, putative
similar to GP:790933: invariant surface glycoprotein {Trypanosoma brucei}(PMID:7723788)
identical to GP:161948: 75 kDa invariant surface glycoprotein {Trypanosoma brucei} (PMID:7723788) (PMID:1587856)
similar to GP:790931: invariant surface glycoprotein {Trypanosoma brucei}(PMID:7723788)
similar to GP:790931: invariant surface glycoprotein {Trypanosoma brucei} (PMID:7723788)
identical to GB:AAC41568.1: invariant surface glycoprotein {Trypanosoma brucei} (PMID:7723788)
NADH-ubiquinone oxidoreductase, mitochondrial, putative
similar to GB:AAF68388.1: stomatin-like protein {Zea mays}; similar to GB:AAO46793.1: stomatin-like protein {Leishmania enriettii}
similar to SP:P12953: Vacuolar ATP synthase subunit d (EC 3.6.3.14) (V-ATPase d subunit) (Vacuolar proton pump d subunit) (V-ATPase AC39 subunit) (V-ATPase 40 kDa accessory protein) (P39) (32 kDa accessory protein). [Bovine] {Bos taurus}
protein phosphatase 1, regulatory subunit, putative
similar to SP:P22194: Protein phosphatases PP1 regulatory subunit sds22. {Schizosaccharomyces pombe}
similar over 348aa to Sialidase (EC 3.2.1.18) (Neuraminidase) (NA) (Major surface antigen). (Swiss-Prot:P23253) [Trypanosoma cruzi]
casein kinase I, epsilon isoform, putative
similarity to GB:AAK58696.1: casein kinase 1.2 {Trypanosoma cruzi} (PMID: 12387847)
oligosaccharyl transferase subunit, putative
similar to Oligosaccharyl transferase STT3 subunit homolog (B5) (Integral membrane protein 1). (Swiss-Prot:P46978) [Mus musculus;]
similar to Oligosaccharyl transferase STT3 subunit homolog (B5) (Integralmembrane protein 1). (Swiss-Prot:P46978) [Mus musculus]
similar to similar to Heat shock protein 67B2. (Swiss-Prot:P22978) [Drosophila melanogaster]
similar to GB:AAN40014.1: NADH-dependent fumarate reductase {Trypanosoma brucei}(PMID:12138089)
NADH-dependent fumarate reductase, putative
similar to GB:AAN40014.1: NADH-dependent fumarate reductase {Trypanosoma brucei} (PMID:12138089)
ubiquitin-conjugating enzyme E2, putative
similar to GB:AAN75008.1: disulfide isomerase PDI {Leishmania major}; similar to Protein disulfide isomerase precursor (EC 5.3.4.1) (PDI). (Swiss-Prot:Q12730) {Aspergillus niger}
mitochondrial processing peptidase, beta subunit, putative
similar to Mitochondrial processing peptidase beta subunit, mitochondrialprecursor (EC 3.4.24.64) (Beta-MPP) (P-52). (Swiss-Prot:Q03346) [Rattus norvegicus;]
similar to GB:AAD54220.1: peroxisome targeting signal 1 receptor PEX5 {Trypanosoma brucei}(PMID: 10589985) similar to GB:AAF67841.1: peroxisomal targeting signal-1 receptor {Leishmania donovani} (PMID:10788481)
sequence corresponds to BAC RPCI93-30H13
pre-mRNA splicing factor ATP-dependent RNA helicase, putative
similar to Putative pre-mRNA splicing factor RNA helicase (DEAH box protein 15)(ATP-dependent RNA helicase #46). (Swiss-Prot:O43143) [Homo sapiens]
identical to GB:CAC39254.1: Csl4p homologue {Trypanosoma brucei} (PMID:11447124)
vacuolar proton translocating ATPase subunit A, putative
protoheme IX farnesyltransferase, putative
cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
65 kDa invariant surface glycoprotein, putative
similar to SP:P36060: NADH-cytochrome b5 reductase precursor (EC 1.6.2.2) (P34/P32). {Saccharomyces cerevisiae} (PMID:8001120)
heat shock protein HslVU, ATPase subunit HslU, putative
Similar to GB|CAD21591.1|25956194|LIN428522 : regulatory subunit of the HslVU complex {Leishmania infantum} (PMID:12446803)
ATP-dependent DEAD/H RNA helicase, putative
serine/threonine-protein kinase, putative
similar to Protein phosphatase 2C homolog 2 (EC 3.1.3.16) (PP2C-2). (Swiss-Prot:Q09172) [Schizosaccharomyces pombe]
replication Factor A 28 kDa subunit, putative
ribonucleoprotein p18, mitochondrial precursor, putative
similar to SP:Q25423: P18 protein, mitochondrial precursor. {Leishmania tarentolae}
lysosomal/endosomal membrane protein p67
identical to GB:AAC28456.1: lysosomal/endosomal membrane protein p67 {Trypanosoma brucei rhodesiense} (PMID:10029306)
Lysosomal/endosomal membrane protein p67. May contain misassembly at its C-terminal.
Lysosomal/endosomal membrane protein p67. May contain misassembly at its C-terminal. identical to GB:AAC28456.1: lysosomal/endosomal membrane protein p67 {Trypanosoma brucei rhodesiense} (PMID:10029306)
Repetitive protein. Number of repetitive motif uncertain.
Ribosomal mobile element. May contain misassembly.
similar to Cell division control protein 5. (Swiss-Prot:P39964) [Schizosaccharomyces pombe]
inosine-5'-monophosphate dehydrogenase, putative
similar to SP:O13765: Lariat debranching enzyme (EC 3.1.-.-). {Schizosaccharomyces pombe} (PMID: 9001235)
regulator of nonsense transcripts 1, putative
similar to GB:AAC47003.1: infective insect stage-specific protein {Leishmania major}
Similar to GP:2921428: infective insect stage-specific protein {Leishmania donovani}
similar to GB:AAR91713.1: meta 2 protein {Leishmania amazonensis}
similar to GP:1237122: infective insect stage-specific protein {Leishmania major}
similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51) (1-AGP acyltransferase 4) (1-AGPAT 4) (Lysophosphatidic acidacyltransferase-delta) (LPAAT-delta) (1-acylglycerol-3-phosphate O-acyltransferase 4). (Swiss-Prot:Q9NRZ5) [Homo sapiens;]
similar to SP:O75643: U5 small nuclear ribonucleoprotein 200 kDa helicase (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Fragment). [Human] {Homo sapiens}
hydrolase, alpha/beta fold family, putative
similar to GB:BAD13383.1: streptothricin acetyl-transferase {Escherichia coli}
ubiquitin carboxyl-terminal hydrolase, putative
similar over 204aa to Ribosomal RNA small subunit methyltransferase B (SUN) protein. (Swiss-Prot:P94464) [Bacillus subtilis;]
similar to Myosin heavy chain, skeletal muscle, juvenile. (Swiss-Prot:Q28641) {Oryctolagus cuniculus}
5'-3' exonuclease (pseudogene), putative; Deletion of adenosine 497 restores the open reading frame. This residue is absent in other BACs anchored on the same genomic region, indicating that one allele (this model) contains a frameshift that disrupts the ORF but the other allele is complete. XRNB: pers. comm. C. Clayton, University of Heidelberg.
Adenosine residue absent in other BACs anchored on the same genomic region (RPCI93-29N22, RPCI93-29M12, RPCI93-30M6 and RPCI93-26P12). Deletion of this nucleotide restores the open reading frame of the associated model.
Adenosine residue substituted by a guanosine residue in other BACs anchored in the same genomic region (RPCI93-29N22, RPCI93-29M12, RPCI93-30M6 and RPCI93-26P12).
hypothetical protein, conserved (pseudogene)
inositol-1(or 4)-monophosphatase 1, putative
similar to Inositol-1(or 4)-monophosphatase 1 (EC 3.1.3.25) (IMPase 1) (IMP 1)(Inositol monophosphatase 1). (Swiss-Prot:P54926) [Lycopersicon esculentum]
similar to SP:Q62384: Zinc-finger protein ZPR1 (Zinc finger protein 259).{Mus musculus}
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative : curated by Mike Ferguson.
identical to GB:AY354517: DNA polymerase beta {Trypanosoma brucei} (PMID:12966090)
similar to GB:AY354516 : DNA polymerase beta-PAK {Trypanosoma brucei} (PMID: 12966090); simiar to GB:AAA68599.2: DNA polymerase beta {Crithidia fasciculata}
similar to GP:9802011: juvenile hormone-inducible protein 1 {Drosophila melanogaster} (PMID:10926782)
similar to GP:8388663: NEK-related serine/threonine-protein kinase nek1 {Leishmania major} (PMID:1382974)
similar to GP:19310965: histone deacetylase-like protein HDO4 {Trypanosoma brucei}(PMID:12100550)
similar to Swiss-Prot:Q9D9X6 : Zinc finger SWIM domain containing protein 2 {Mus musculus} Predicted phorbol esters/diacylglycerol binding domain (Pfam C1 domain PF00130) below Pfam recommended threshold at residues 193-222 (pers. comm. K. Mensa-Wilmot, University of Georgia).
similar to GP:1698880: protein antigen LmSTI1 {Leishmania major}(PMID:8943412) similar to Trypanosoma cruzi TcSTI1 (unpublished)
phosphoribosylpyrophosphate synthetase, putative
similar to GP:159398: phosphoribosylpyrophosphate synthetase {Leishmania donovani}(PMID:8390611)
similar to SP:Q91ZR4: Serine/threonine-protein kinase Nek8 (EC 2.7.1.37) (NimA-relatedprotein kinase 8). {Mus musculus}
ribose-phosphate pyrophosphokinase, putative
similar to Probable ribose-phosphate pyrophosphokinase 5 (EC 2.7.6.1)(Phosphoribosyl pyrophosphate synthetase 5). (Swiss-Prot:Q12265) [Saccharomyces cerevisiae]
similar to Ubiquitin-like protein SMT3. (Swiss-Prot:P55857) [Oryza sativa]; similar to Ubiquitin-like protein SMT3C precursor (Ubiquitin-homology domainprotein PIC1) (Ubiquitin-like protein UBL1) (Ubiquitin-related proteinSUMO-1) (GAP modifying protein 1) (GMP1) (Sentrin). (Swiss-Prot:Q93068) [Homo sapiens;Mus musculus]
similar to similar to Protein kinase byr1 (EC 2.7.1.-) (MAPK kinase) (MAPKK). (Swiss-Prot:P10506) [Schizosaccharomyces pombe]; similar to Protein kinase C, zeta type (EC 2.7.1.37) (nPKC-zeta). (Swiss-Prot:O19111) [Oryctolagus cuniculus]
similar to GP:13488615: iron superoxide dismutase A {Trypanosoma cruzi}(PMID:9200125); similar to GP:2352425: iron superoxide dismutase {Leishmania chagasi}(PMID:9497044)
similar to PIR:A45598: H+-exporting ATPase - SP:P35315: Probable calcium-transporting ATPase (Calcium pump). {Trypanosoma brucei brucei}; similar to GB:AAD08694.1: SERCA-type calcium-ATPase {Trypanosoma cruzi}; similar to GB:AAC47505.1: organelle-type Ca2+-ATPase {Leishmania amazonensis}
ubiquitin-activating enzyme E1, putative
similar to Ubiquitin-like 2 activating enzyme E1B (SUMO-1 activating enzymesubunit 2) (Anthracycline-associated resistance ARX) (HRIHFB2115) (Swiss-Prot:Q9UBT2) [Homo sapiens]
structural maintenance of chromosome 3, putative
similar to Structural maintenance of chromosome 3 (Cohesin complex Psm3 subunit). (Swiss-Prot:O42649) [Schizosaccharomyces pombe;]
queuine tRNA-ribosyltransferase, putative
vesicle-associated membrane protein, putative
similar to Vesicle-associated membrane protein 713 (AtVAMP713). (Swiss-Prot:Q9LFP1) [Arabidopsis thaliana]
phosphoglycerate mutase protein, putative
similar to 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (EC 5.4.2.1)(Phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) (dPGM). (Swiss-Prot:Q8KL44) [Rhizobium etli;]
similar to Adapter-related protein complex 3 delta 1 subunit (Delta-adaptin 3)(AP-3 complex delta subunit) (Delta-adaptin). (Swiss-Prot:O14617) [Homo sapiens;]
dual-specificity protein phosphatase, putative
similar to Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 5) (MAP kinasephosphatase 5) (MKP-5). (Swiss-Prot:Q9Y6W6) [Homo sapiens;]
similar to SP:Q92889: DNA-repair protein complementing XP-F cell (Xeroderma pigmentosum group F complementing protein) (DNA excision repair protein ERCC-4). [Human] {Homo sapiens}
Sphingomyelin phosphodiesterase, putative
similar to Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Neutralsphingomyelinase) (nSMase) (N-SMase) (Lyso-platelet activating factor-phospholipase C) (Lyso-PAF-PLC) (Swiss-Prot:O60906) [Homo sapiens]
similar to Glycine-rich RNA-binding protein. (Swiss-Prot:Q03878) [Daucus carota]
meiotic recombination protein SPO11, putative
glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative
identical to GP|4210453|dbj|BAA74521.1||AB017765 GATase-CPSase {Trypanosoma cruzi} (PMID:9878395)
orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative
similar to GP:4995976: OMPDCase-OPRTase {Trypanosoma cruzi} (PMID:9878395)
aspartate carbamoyltransferase, putative
similar to GP:16923277: aspartate carbamoyltransferase (ACTase){Trypanosoma cruzi} (PMID: 12865084)
similar to PIR:T30523: dihydroorotate dehydrogenase (EC 1.3.99.11){Trypanosoma cruzi} (PMID:9878395)
similar to Tubulin tyrosine ligase-like protein 1. (Swiss-Prot:O95922) [Homo sapiens;]
similar to GB:AAH60250.1: protein arginine N-methyltransferase 4 {Mus musculus}
sequence corresponds to BAC RPCI93-45E22
U6 snRNA-associated Sm-like protein LSm7p
identical to GB|AY551265 Trypanosoma brucei Lsm7p {Trypanosoma brucei}(PMID:14990572)
Part of an H4 histone array. Number of copies in the array is uncertain.
Histone H4 array, number of copies uncertain.
similar to Protease II (EC 3.4.21.83) (Oligopeptidase B). (Swiss-Prot:P24555) [Escherichia coli]
dihydrolipoamide branched chain transacylase, putative
similar to Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168)(Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2)(Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit). (Swiss-Prot:P53395) [Mus musculus]
similar to (Di)nucleoside polyphosphate hydrolase (EC 3.6.1.-) (Ap4Apyrophosphatase) (Invasion protein A) (Invasion associated locusprotein A). (Swiss-Prot:P35640) [Bartonella bacilliformis;]
serine/threonine protein phosphatase, putative
similar to SP:Q9JIK5: Nucleolar RNA helicase II (Nucleolar RNA helicase Gu) (RH II/Gu)(DEAD-box protein 21). {Mus musculus}
similar to Major vault protein alpha (MVP-alpha). (Swiss-Prot:P34118) [Dictyostelium discoideum]; similar to Major vault protein (MVP) (Lung resistance-related protein) (Swiss-Prot:Q14764) [Homo sapiens]
paraflagellar rod component Par4, putative
similar to GP:2865631: paraflagellar rod component Par4 {Trypanosoma cruzi}(PMID:9705323) similar to GP:27977392: paraflagellar rod protein 4 {Leishmania mexicana}
similar to GTP-binding protein SAR1B. (Swiss-Prot:Q01474) [Arabidopsis thaliana]
elongation of very long chain fatty acids protein, putative
similar to Elongation of very long chain fatty acids protein 2. (Swiss-Prot:Q9JLJ4) [Mus musculus]
small GTP-binding rab protein (pseudogene), putative
variant surface glycoprotein (VSG, pseudogene)-related, putative; VSG-related: pers. comm. Dave Barry (University of Glasgow, UK)
Similar to GP:1791291: metacyclic variable antigen variant surface glycoprotein 7 {Trypanosoma brucei}(PMID:9305933)
variant surface glycoprotein (VSG), putative
variant surface glycoprotein (VSG, pseudogene), putative; similar to GP:1791291: metacyclic variable antigen variant surface glycoprotein 7 {Trypanosoma brucei}(PMID:9305933)
sequence corresponds to BAC RPCI93-25P15
variant surface glycoprotein (VSG, pseudogene), putative; identical to SP:P26331: Variant surface glycoprotein MITAT 1.1 precursor (VSG). {Trypanosoma brucei brucei}(PMID:1942032)
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase (pseudogene), putative