Trypanosoma brucei brucei TREU927 chromosome 4, complete sequence.
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma.
The genome of the African trypanosome Trypanosoma brucei
Comparative genomics of trypanosomatid parasitic protozoa
Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8
Submitted (10-APR-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-APR-2005) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP000067.\nOn or before Oct 11, 2006 this sequence version replaced\nNW_921296.1, NW_921343.1, NW_921325.1, NW_921322.1, NW_921306.1,\nNW_921324.1, NW_921310.1, NW_921329.1, NW_921261.1, NW_921336.1,\nNW_921337.1, NW_921309.1.\nChromosome lacks telomere sequences.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
single VAT derivative of TREU (Trypanosomiasis Research Edinburgh University) 927/4 (GPAL/KE/70/EATRO 1534)
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS1, interrupted by a RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS1, interrupted by a RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
receptor-type adenylate cyclase GRESAG 4 (pseudogene), putative
leucine-rich repeat protein (LRRP, pseudogene), putative
retrotransposon hot spot protein (RHS, pseudogene), putative
retrotransposon hot spot (RHS) protein, putative
RHS1, chimeric gene between RHS5 (N-terminal) and RHS1 (C-terminal): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS2, interrupted by a RIME. Chimeric pseudogene between RHS3 (N-terminal domain) and RHS2 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS2, interrupted by a RIME. Chimeric pseudogene between RHS3 (N-terminal domain) and RHS2 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
DNA-directed RNA polymerase III subunit (pseudogene), putative
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS4. Chimeric pseudogene betwen RHS2 (N-terminal domain) and RHS4 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
RHS5: pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
RHS3. Chimeric gene between RHS1 (N-terminal domain) and RHS3 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
similar to Polyadenylate-binding protein (Poly(A)-binding protein) (PABP). (Swiss-Prot:P31209) [Schizosaccharomyces pombe]
phosphatidylinositol 3-kinase tor, putative
identical to GP:12656357: 20S proteasome beta 7 subunit {Trypanosoma brucei}(PMID:11309374)
Alkylated DNA repair protein (alkB homolog), putative
CH3-like dynein heavy chain, likely role in intraflagellar transport : urated by B. Wickstead, Univ. of Oxford.
geranylgeranyl transferase type II beta subunit, putative
similar to Geranylgeranyl transferase type II beta subunit (EC 2.5.1.60) (Rabgeranylgeranyltransferase beta subunit) (Rab geranyl-geranyltransferase beta subunit) (Rab GG transferase beta) (Rab GGTasebeta). (Swiss-Prot:P53611) [Homo sapiens]
similar to Adapter-related protein complex 1 gamma 1 subunit (Gamma-adaptin)(Adaptor protein complex AP-1 gamma-1 subunit) (Golgi adaptor HA1/AP1adaptin gamma-1 subunit) (Clathrin assembly protein complex 1 gamma-1large chain). (Swiss-Prot:P22892) [Mus musculus;]
expression site-associated gene (ESAG) protein, putative
TPR-repeat-containing chaperone protein DNAJ, putative
similar to Cysteine string protein. (Swiss-Prot:Q03751) [Drosophila melanogaster]; similar to DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP). (Swiss-Prot:Q9H3Z4) [Homo sapiens;]
small nuclear ribonucleoprotein SmD3, putative
similar to: GP:9837180: Sm-D3 {Trypanosoma cruzi} PMID:10900267
similar to SP:P53467: Actin, larval muscle-type (A1). {Molgula oculata}
serine-palmitoyl-CoA transferase, putative
similar to Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain basebiosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1)(SPT 1) (SPT1). (Swiss-Prot:O35704) [Mus musculus;]
similar to Hypothetical 22 kDa protein in aldolase locus (ORFI). (Swiss-Prot:P17960) [Trypanosoma brucei brucei;]
similar to SP:Q26975: Vacuolar ATP synthase catalytic subunit A (EC 3.6.3.14) (V-ATPase Asubunit) (Vacuolar proton pump alpha subunit) (V-ATPase 69 kDasubunit). {Trypanosoma congolense}
endosomal integral membrane protein, putative
similar to Phosphatidylinositol 4-kinase (EC 2.7.1.67) (PI4-kinase) (PtdIns-4-kinase) (PI4K-alpha) (Swiss-Prot:P54677) [Dictyostelium discoideum]
leucine-rich repeat protein (LRRP), putative
peroxisome biogenesis factor 1, putative
cleavage and polyadenylation specificity factor subunit, putative
similar to Cleavage and polyadenylation specificity factor, 73 kDa subunit (CPSF73 kDa subunit). (Swiss-Prot:P79101) [Bos taurus] and (Swiss-Prot:Q9UKF6) [Homo sapiens]
hydroxyacylglutathione hydrolase, putative
similar to Hydroxyacylglutathione hydrolase cytoplasmic (EC 3.1.2.6) (GlyoxalaseII) (Glx II). (Swiss-Prot:O24496) [Arabidopsis thaliana]
phospholipid-translocating ATPase, putative
phosphatidylinositol 4-phosphate 5-kinase alpha, putative
similar to Phosphatidylinositol-4-phosphate 5-kinase type II alpha (EC 2.7.1.149)(PIP5KII-alpha) (1-phosphatidylinositol-4-phosphate 5-kinase)(PtdIns(4)P-5-kinase B isoform) (Diphosphoinositide kinase). (Swiss-Prot:O70172) [Mus musculus]
identical to: B:CAC39261.1: Rrp6p homologue {Trypanosoma brucei}
lipophosphoglycan biosynthetic protein 2, putative
similar to Damage response protein 1. (Swiss-Prot:Q12091) [Saccharomyces cerevisiae;]
similar to Nucleoside diphosphate kinase (EC 2.7.4.6) (NDK) (NDP kinase)(Nucleoside-2-P kinase) (Swiss-Prot:Q9QXL7) [Rattus norvegicus]
similar to GB:AAF62506.1: ribosomal protein L3 {Trypanoplasma borreli}
ribosomal protein L3, mitochondrial, putative
sequence corresponds to BAC RPCI93-29M18
selenocysteine-tRNA-specific elongation factor, putative
similar to SP:Q9JHW4: Selenocysteine-specific elongation factor (Elongation factor sec)(mSelB). {Mus musculus}; similar to Selenocysteine-specific elongation factor (Elongation factor sec). (Swiss-Prot:P57772) [Homo sapiens;]
metallo-peptidase, Clan MC, Family M14: curated by J. Mottram.
serine/threonine protein phosphatase, putative
glycosylphosphatidylinositol (GPI) anchor, putative
similar along entire length to SP:O75821: Eukaryotic translation initiation factor 3 subunit 4 (eIF-3 delta)(eIF3 p44) (eIF-3 RNA-binding subunit) (eIF3 p42) (eIF3g). {Homo sapiens}
NADPH--cytochrome p450 reductase, putative
similar to NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R). (Swiss-Prot:P16435) [Homo sapiens]
similar to ATP-dependent RNA helicase SUV3, mitochondrial precursor. (Swiss-Prot:P32580) [Saccharomyces cerevisiae]
similar to GB:AAF75257.2: acyl-CoA binding protein {Trypanosoma brucei} (PMID:10777537)
similar to Adapter-related protein complex 3 mu 1 subunit (Mu-adaptin 3A) (AP-3adapter complex mu3A subunit) (Swiss-Prot:Q9Y2T2) [Homo sapiens]
similar to Myosin heavy chain, striated muscle. (Swiss-Prot:P24733) {Argopecten irradians}
similar to Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16)(CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2)(Protein phosphatase 1F). (Swiss-Prot:P49593) [Homo sapiens;]
similar to SP:Q99615: DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2)(TPR repeat protein 2). {Homo sapiens}
similar to Glycosyltransferase ALG2 (EC 2.4.1.-) (Swiss-Prot:P43636) [Saccharomyces cerevisiae]
similar to Probable transport protein (LTP). (Swiss-Prot:P13865) [Leishmania enriettii] and similar to Glucose transporter 2A. (Swiss-Prot:Q06222) [Trypanosoma brucei brucei]
similar to SP:O43776: Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (Asparagine--tRNA ligase) (AsnRS). {Homo sapiens}
sarcoplasmic reticulum glycoprotein, putative
similar to Sarcalumenin precursor (Swiss-Prot:P13666) [Oryctolagus cuniculus]
similar to ATP-dependent helicase DHX8 (RNA helicase HRH1) (DEAH-box protein 8). (Swiss-Prot:Q14562) [Homo sapiens] and similar to Pre-mRNA splicing factor RNA helicase PRP22. (Swiss-Prot:P24384) [Saccharomyces cerevisiae]
similar to GB:AAF45013.1: symbol {Drosophila melanogaster}
dual specificity protein phosphatase, putative
similar to GB:CAA77232.1: DsPTP1 protein {Arabidopsis thaliana}; similar to Dual specificity protein phosphatase (EC 3.1.3.48) (EC 3.1.3.16). (Swiss-Prot:Q39491) [Chlamydomonas eugametos]
identical to GP:27764447: putative 8-oxoguanine DNA glycosylase {Trypanosoma brucei} (PMID:14706348)
similar to Eukaryotic translation initiation factor 2-alpha kinase precursor(EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK)(DmPEK). (Swiss-Prot:Q9NIV1) [Drosophila melanogaster;]
multidrug resistance-associated protein, putative
similar to GP:20271162: multidrug resistance-associated protein 7B {Mus musculus}
similar to SP:P97013: NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2homolog). {Salmonella typhi;Salmonella typhimurium}
ATP-dependent DEAD/H RNA helicase, putative
similar to HECT domain and RCC1-like domain protein 3. (Swiss-Prot:Q15034) {Homo sapiens}
pyroglutamyl-peptidase I (PGP), putative
hydroxymethylglutaryl-CoA lyase, putative
ubiquitin-conjugating enzyme E2, putative
similar to ATP-dependent RNA helicase srmB. (Swiss-Prot:P21507) {Escherichia coli}
mitochondrial DNA polymerase I protein A, putative
ATP-dependent DEAH-box RNA helicase, putative
similar to Dosage compensation regulator (Male-less protein) (No action potential protein). (Swiss-Prot:P24785) [Drosophila melanogaster]
tRNA-dihydrouridine synthase 4, putative
similar to tRNA-dihydrouridine synthase 4 (DUS4) (EC 1.-.-.-) (Swiss-Prot:Q06063) [Saccharomyces cerevisiae]
dihydroxyacetone phosphate acyltransferase, putative
similar to Dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42) (DHAP-AT)(DAP-AT) (Glycerone-phosphate O-acyltransferase) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase). (Swiss-Prot:O15228) [Homo sapiens]
similar to GB:CAB43348.1: ESAG11 protein {Trypanosoma brucei}
similar to PIR:S48172: variable surface glycoprotein (clone BENat 1){Trypanosoma congolense}
mitochondrial ATP-dependent zinc metallopeptidase, putative
similar to SP:Q9Y4W6: AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein). [Human] {Homo sapiens}(PMID:11549317)
uracil phosphoribosyltransferase, putative
serine/threonine-protein kinase, putative
DNA-directed RNA polymerase subunit, putative
similar to DNA-directed RNA polymerases I, II, and III 15 kDa polypeptide(EC 2.7.7.6) (RPABC6) (Swiss-Prot:P36595) [Schizosaccharomyces pombe]
serine/threonine protein phosphatase PP1, putative
similar to GB:AAF37821.1: type 1 serine/threonine phosphoprotein phosphatase PP1beta {Trypanosoma cruzi}
translation elongation factor 1-beta, putative
similar to SP:P34827: 25 kDa elongation factor 1-beta (EF-1-beta). {Trypanosoma cruzi}; similar to Probable elongation factor 1-beta (EF-1-beta) (Swiss-Prot:O96827) [Drosophila melanogaster]
similar to SP:P34827: 25 kDa elongation factor 1-beta (EF-1-beta) {Trypanosoma cruzi}
serine/threonine-protein phosphatase PP1, putative
similar to GB:AAM43836.1: T-cell activation protein phosphatase 2C {Homo sapiens}
sequence corresponds to BAC RPCI93-30O21
receptor-type adenylate cyclase GRESAG 4, putative
similar to GB:CAD21877.1: ESAG4 {Trypanosoma brucei}
ubiquitin carboxyl-terminal hydrolase, putative
DNA-directed RNA polymerase II subunit 2, putative
similar to GB:AAH00656.1 nucleolar protein 1 (120kD) Swiss-Prot:P46087 {Homo sapiens}
mitotic centromere-associated kinesin (MCAK), putative
similar to SP:Q922S8: Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin)(MCAK). {Mus musculus}
calpain-like cysteine peptidase, putative
cytoskeleton-associated protein CAP5.5, putative
identical to GB:AAG48626.1: cytoskeleton-associated protein CAP5.5 {Trypanosoma brucei}
similar to Chaperone protein dnaJ (Immunoreactive heat shock protein dnaJ). (Swiss-Prot:Q9XCA6) [Porphyromonas gingivalis;]
similar to SP:P16970: ATP-binding cassette, sub-family D, member 3 (70 kDa peroxisomalmembrane protein) (PMP70). {Rattus norvegicus}
similar to Mevalonate kinase (EC 2.7.1.36) (MK). (Swiss-Prot:Q58487) {Methanocaldococcus jannaschii}
similar to Putative rRNA methyltransferase SPB1 (EC 2.1.1.-). (Swiss-Prot:P25582) [Saccharomyces cerevisiae;]
similar to Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2)(Calcium-promoted Ras inactivator). (Swiss-Prot:O43374) [Homo sapiens]
ATP-dependent zinc metallopeptidase, putative
similar to Ras-related protein Rab-39B. (Swiss-Prot:Q96DA2) [Homo sapiens]
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative : curated by Mike Ferguson.
divalent cation tolerance protein, putative
vacuolar-type proton translocating pyrophosphatase 1, putative
similar to GP:21654895: vacuolar-type proton translocating pyrophosphatase 1 {Trypanosoma brucei}.
similar to GB:AAF69135.1: adenylyl cyclase {Trypanosoma brucei} (PMID:11166383)
similar to GB:AAF69135.1: adenylyl cyclase {Trypanosoma brucei} (PMID:11166383); similar to GB:CAD21877.1: ESAG4 {Trypanosoma brucei}
identical to GP:16304674: multidrug resistance protein E {Trypanosoma brucei brucei}(PMID:11918801)
similar to Protein phosphatase 2C homolog 3 (EC 3.1.3.16) (PP2C-3). (Swiss-Prot:Q09173) [Schizosaccharomyces pombe]
similar to Pistil-specific extensin-like protein precursor (PELP). (Swiss-Prot:Q03211) {Nicotiana tabacum}
cytochrome c oxidase VIII (COX VIII), putative
COX VIII: curated by Dr. Keith Matthews (University of Manchester). Evidence is based on purification of the components of the cytochrome oxidase complex and N-terminal sequence determination. Manuscript in preparation.
3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative
similar to 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8)(Dodecenoyl-CoA delta-isomerase). (Swiss-Prot:P23965) [Rattus norvegicus;]
similar to Zinc transporter 2 (ZnT-2). (Swiss-Prot:Q62941) [Rattus norvegicus]
similar to Ferredoxin, 2Fe-2S. (Swiss-Prot:Q92J08) [Rickettsia conorii;]
ubiquinol-cytochrome C reductase, putative
similar to Calreticulin precursor. (Swiss-Prot:Q9ZNY3) [Euglena gracilis]
similar to GP:162215: RNA polymerase IIA largest subunit {Trypanosoma brucei}(PMID:2924350)
serine/threonine protein phosphatase PP1
similar to SP:P23733: Serine/threonine protein phosphatase PP1(4.8) (EC 3.1.3.16). {Trypanosoma brucei brucei}
dihydrolipoamide dehydrogenase, putative
similar to SP:P54533: Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (E3 component of branched-chain alpha-keto acid dehydrogenase complex) (LPD-Val)(Dihydrolipoamide dehydrogenase). {Bacillus subtilis}
dihydrolipoamide dehydrogenase (pseudogene), putative
similar to GB:AAA30209: kinetoplast-associated protein {Trypanosoma cruzi}
sequence corresponds to BAC RPCI93-24M18
serine/threonine-protein kinase A, putative
3-methylcrotonyl-CoA carboxylase (pseudogene), putative
hypothetical protein, conserved (pseudogene); Overlapping BAC (RPCI-93:3M17) contains a complete gene.
dynein light chain 2B, cytoplasmic, putative
identical to SP:Q08942: Putative serine/threonine-protein kinase A (EC 2.7.1.37). {Trypanosoma brucei brucei}
variant surface glycoprotein (VSG, atypical), putative
variant surface glycoprotein (VSG, pseudogene), putative
variant surface glycoprotein (VSG), putative
expression site-associated gene (ESAG, pseudogene), putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase (pseudogene), putative
similar to SP:P26328: Variant surface glycoprotein ILTAT 1.23 precursor (VSG). {Trypanosoma brucei brucei}(PMID:1942032)