Trypanosoma brucei brucei TREU927 chromosome 2, complete sequence.
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma.
The genome of the African trypanosome Trypanosoma brucei
Comparative genomics of trypanosomatid parasitic protozoa
Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8
Submitted (10-APR-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (12-APR-2005) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to AE017150.\nOn Dec 29, 2005 this sequence version replaced NC_005063.1.\nChromosome lacks telomere sequences.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
single VAT derivative of TREU (Trypanosomiasis Research Edinburgh University) 927/4 (GPAL/KE/70/EATRO 1534)
retrotransposon hot spot (RHS) protein, putative
RHS1: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
leucine-rich repeat protein (LRRP), putative
expression site-associated gene (ESAG, pseudogene), putative
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS2, interrupted by an ingi retrotransposon. The C-terminal domain was probably lost : pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
RHS5: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS3,chimeric pseudogene between RHS1 (N-terminal domain) and RHS3 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
RHS2: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
DNA-directed RNA polymerase (pseudogene), putative
RHS4: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS2, chimeric pseudogene between RHS3 (N-terminal domain) and RHS2 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
RHS4, chimeric gene between RHS1 (N-terminal domain) and RHS4 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
RHS4, chimeric gene between RHS1 (N-terminal) and RHS4 (C-terminal): pers. comm. Frederic Bringaud, CNRS/BordeauxII University.
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS5: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS1, interrupted by the insertion of 3 copies of RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS1, interrupted by the insertion of 3 copies of RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
sequence corresponds to BAC RPCI93-25N24
similar to GP:18378049: hypothetical protein {Trypanosoma brucei}
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS1, interrupted by an ingi retrotransposon. Chimeric pseudogene between RHS2 (N-terminal domain) and RHS1 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS1, interrupted by a RIME. Chimeric pseudogene between RHS2 (N-terminal domain) and RHS1 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS3: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
DNA-directed RNA polymerase III subunit 2 (pseudogene), putative
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS4. Chimeric pseudogene between RHS5 (N-terminal domain) and RHS4 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS3, interrupted by a RIME. Chimeric pseudogene between RHS1 (N-terminal domain) and RHS3 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS3, interrupted by a RIME. Chimeric pseudogene between RHS1 (N-terminal domain) and RHS3 (C-terminal domain): pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; C-terminal domain of an RHS2, interrupted by a RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative; N-terminal domain of an RHS2, interrupted by a RIME: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
RHS3: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
leucine-rich repeat protein (LRRP, pseudogene), putative
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS6: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
retrotransposon hot spot protein (RHS, pseudogene), putative
retrotransposon hot spot protein (RHS, pseudogene), putative; RHS1: pers. comm. Frederic Bringaud, CNRS/BordeauxII University. Belongs to the RHS family. (PMID:12455980)
sequence corresponds to BAC RPCI93-27H14
cyclophilin type peptidyl-prolyl cis-trans isomerase precursor, putative
similar to GB:CAA73904 cyclophilin [Leishmania major]
cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative
hypothetical protein, conserved (pseudogene)
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein, putative
identical to GB:AAQ15636.1: N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein, putative {Trypanosoma brucei}
DNA polymerase delta catalytic subunit, putative
similar to DNA polymerase delta catalytic subunit (EC 2.7.7.7). (Swiss-Prot:O54747) [Rattus norvegicus;]
similar to Possible global transcription activator SNF2L1. (Swiss-Prot:P28370) [Homo sapiens]; similar to Iswi protein (Imitation swi protein) (Nucleosome remodeling factor 140kDa subunit) (NURF-140) (CHRAC 140 kDa subunit). (Swiss-Prot:Q24368) [Drosophila melanogaster;]
sequence corresponds to BAC RPCI93-25N14
autophagocytosis associated protein, putative
expression site-associated gene (ESAG) protein, putative
identical to GB:AAQ15650.1: expression site associated protein 5, putative {Trypanosoma brucei}
variant surface glycoprotein (VSG)-related, putative
small GTP-binding protein RAB6, putative
identical to GB:AAQ15670.1: small GTP binding protein RAB6, putative {Trypanosoma brucei}; similar to GB:AAF34783.1: RAB6 protein {Toxoplasma gondii}
similar to GP:14250914: Rrp41p homologue {Trypanosoma brucei} (PMID:11447124) Essential gene, at least in the insect form of the parasite, RNAi phenotype lethal in procyclics. Component of the T. brucei exosome complex, involved in maturation of 5.8S rRNA.(PMID:11447124)
phosphatidylinositol kinase domain protein, putative
proteasome regulatory non-ATPase subunit 6
identical to GB:AAQ15701.1: proteasome regulatory non-ATPase subunit 6 {Trypanosoma brucei} (PMID:11854272)
ribosomal RNA methyltransferase, putative
similar to Putative rRNA methyltransferase SPB1 (EC 2.1.1.-). (Swiss-Prot:P25582) [Saccharomyces cerevisiae;]
ubiquitin-conjugating enzyme E2, putative
similar to GP:14495336: RNA-editing complex protein MP81 {Trypanosoma brucei}
similar to SP:Q62925: Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.1.-) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1). [Rat] {Rattus norvegicus}
ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative : curated by Mike Ferguson.
sequence corresponds to BAC RPCI93-28H13
D-alanyl-glycyl endopeptidase-like protein
similar to Glutathionylspermidine synthase (EC 6.3.1.8). (Swiss-Prot:P90518) {Crithidia fasciculata}
similar to Bifunctional glutathionylspermidine synthetase/amidase) (GSP synthetase); Glutathionylspermidine amidase(EC 3.5.1.78) (Glutathionylspermidine amidohydrolase) (GSP amidase)). (Swiss-Prot:P43675) [Escherichia coli;Shigella flexneri;]
transcription elongation factor S-II, putative
identical to GB:AAQ15815.1: transcription elongation factor S-II, putative {Trypanosoma brucei}; similar to Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o). (Swiss-Prot:P23193) [Homo sapiens]
GTP-binding elongation factor Tu family, putative
translation initiation factor IF-2, putative
heterogeneous nuclear ribonucleoprotein H/F, putative
HnRNPH/F: pers. comm. C. Clayton, University of Heidelberg; identical to GB:AAQ15845.1: ribonucleoprotein F, putative {Trypanosoma brucei}; similar to SP:P31943: Heterogeneous nuclear ribonucleoprotein H (hnRNP H).{Homo sapiens}
beta-ketoacyl synthase family protein, putative
minichromosome maintenance (MCM) complex subunit, putative
similar to Auxin-resistance protein AXR1. (Swiss-Prot:P42744) [Arabidopsis thaliana;]
similar to SP:Q39578: Dynein, 78 kDa intermediate chain, flagellar outer arm (IC78). {Chlamydomonas reinhardtii}
mitochondrial processing peptidase alpha subunit, putative
similar to Mitochondrial processing peptidase alpha subunit, mitochondrialprecursor (EC 3.4.24.64) (Alpha-MPP). (Swiss-Prot:P11914) [Saccharomyces cerevisiae;]
enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative
glycosomal phosphoenolpyruvate carboxykinase
identical to PIR:S48663: phosphoenolpyruvate carboxykinase (ATP) (EC 4.1.1.49) - Trypanosoma brucei; identical to SP:P13735: Phosphoenolpyruvate carboxykinase [ATP], glycosomal (EC 4.1.1.49) (Glycosomal protein P60). {Trypanosoma brucei brucei}
dual specificity protein phosphatase, putative
similar over 136aa to Dual specificity protein phosphatase 19 (EC 3.1.3.48) (Proteinphosphatase SKRP1). (Swiss-Prot:Q8WTR2) [Homo sapiens]
sequence corresponds to BAC RPCI93-30M24
similar to Trypanothione synthetase (EC 6.3.1.9) (Cf-TS). (Swiss-Prot:O60993) [Crithidia fasciculata;]
identical to GP:18844723: DNA repair protein Mre11 {Trypanosoma brucei brucei}
similar over 77aa to Protein inhibitor of activated STAT protein gamma (PIAS-gamma)(PIASy). (Swiss-Prot:Q9JM05) [Mus musculus;]
small nuclear ribonucleoprotein SmD1, putative
similar to Putative rRNA methyltransferase SPB1 (EC 2.1.1.-) (Swiss-Prot:P25582) [Saccharomyces cerevisiae]
similar to SP:Q17297: Unc-119 protein. {Caenorhabditis briggsae}
branched-chain amino acid aminotransferase, putative
identical to GB:AAQ15929.1: RNA-binding protein, putative {Trypanosoma brucei}
dolichyl-P-Man:Man(7)GlcNAc(2)-PP- dolichylalpha(6)-mannosyltransferase, putative
Functional evidence provided by Dr. Simone Leal, PhD, Laboratory of Molecular Parasitology, The Rockefeller University (September 2003); similar to Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6- mannosyltransferase (EC 2.4.1.-) (Mannosyltransferase ALG12 homolog). (Swiss-Prot:Q8VDB2) [Mus musculus]
similar to Serine/threonine/tyrosine interacting protein (Protein tyrosinephosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein). (Swiss-Prot:Q60969) [Mus musculus]
transcription initiation protein, putative
similar to Transcription initiation protein SPT5.(Swiss-Prot:P27692) {Saccharomyces cerevisiae}
similar to Protein phosphatase 2C homolog 3 (EC 3.1.3.16) (PP2C-3). (Swiss-Prot:Q09173) [Schizosaccharomyces pombe;]
vesicle-associated membrane protein, putative
similar to Synaptobrevin-like protein 1. (Swiss-Prot:P51809) [Homo sapiens]
similar to GP:886414: TCJ2 {Trypanosoma cruzi} {Trypanosoma cruzi} (PMID:9566524); similar to SP:Q9QYJ0: DnaJ homolog subfamily A member 2 (mDj3). {Mus musculus}
3-oxoacyl-(acyl-carrier protein) reductase, putative
tyrosyl-DNA Phosphodiesterase (Tdp1), putative
identical to GP:15718371: sedoheptulose-1,7-bisphosphatase {Trypanosoma brucei}
identical to GP:9837176: Sm-D2 {Trypanosoma brucei} PMID:10900267
similar to GP:6249541: hypothetical protein {Trypanosoma brucei}.
similar to GP:6249542: hypothetical protein {Trypanosoma brucei}
ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative
3 frameshifts required for perfect match to SP:P31543: Heat shock protein 100 (CLP protein). {Trypanosoma brucei brucei}
glycosylphosphatidylinositol-specific phospholipase C
identical to SP:P09194: Variant-surface-glycoprotein phospholipase C (EC 3.1.4.47) (VSG lipase) (Glycosylphosphatidylinositol-specific phospholipase C) (GPI-PLC). {Trypanosoma brucei brucei}
sequence corresponds to BAC RPCI93-36E18
identical to GP:6469308: beta prime COP protein {Trypanosoma brucei}
identical to GP:10526: ribosomal protein L44 (AA 1-106) {Trypanosoma brucei}; PIR|S10012|R6UT6A ribosomal protein L36a.e - Trypanosoma bruceiEGAD|95037|103040 ribosomal protein L44 {Trypanosoma brucei}
similar to GP:6249549: hypothetical protein {Trypanosoma brucei}
iron/ascorbate oxidoreductase family protein, putative
variant surface glycoprotein (VSG, pseudogene), putative
variant surface glycoprotein (VSG, pseudogene), putative; Frameshift occurs at the C-terminus
UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase (pseudogene), putative
variant surface glycoprotein (VSG, atypical), putative