Poliovirus, complete genome.
type: Entry
definition: Poliovirus, complete genome.
sequence version: NC_002058.3
sequence date: 2018-08-13
sequence: sequence
division: VRL
label: NC_002058.3
type: RefSeq
SIO_000068: refseq
dblink: PRJNA485481
keyword: RefSeq
keyword: coat protein
keyword: complementary DNA
keyword: genome
keyword: polyprotein
source: Enterovirus C
organism: Enterovirus C
taxonomy: Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Picornavirales; Picornaviridae; Enterovirus.
reference: 1
references: 20859255
reference: 2
references: 20532207
reference: 3
references: 17609276
reference: 4
references: 11836388
reference: 5
references: 9326487
reference: 6
references: 8895586
reference: 7
references: 8855318
reference: 8
references: 8289396
reference: 9
references: 8230467
reference: 10
references: 8253083
reference: 11
references: 1315956
reference: 12
references: 1310772
reference: 13
references: 1656077
reference: 14
references: 2170027
reference: 15
references: 2839690
reference: 16
references: 2839775
reference: 17
references: 6323749
reference: 18
references: 6284987
reference: 19
references: 6283138
reference: 20
references: 6272282
reference: 21
references: 6264310
reference: 22
references: 6250717
reference: 23
references: 6158042
reference: 24
comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from V01149.\nOn or before Jan 17, 2013 this sequence version replaced\nNC_001428.1, NC_014336.1, NC_002058.2.\nSee also entries V01148 (POLIO1A, for another version of this\ngenome) and V01150 (POLIOS1, for the genome of the Sabin 1 strain).\nSee the entry V01148 (POLIO1A) for the sequence reported in [3].\nMature peptides were added to the annotation by NCBI RefSeq Genomes\nstaff.\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000353
sequence length: 7440
topology: linear
so has quality: SO_0000987
location: 1..7440
location: region:1-7440:1
RO_0002162: 138950

NC_002058
type: RefSeq
SIO_000068: refseq

PRJNA485481
type: BioProject
SIO_000068: bioproject

1
title: Polypyrimidine tract-binding protein stimulates the poliovirus IRES by modulating eIF4G binding
author: Kafasla, P.
author: Morgner, N.
author: Robinson, C.V.
author: Jackson, R.J.
journal: EMBO J.
volume: 29
issue: 21
pages: 3710-3722
year: 2010
pubmed: 20859255

20859255
type: PubMed
SIO_000068: pubmed

2
title: An RNA element at the 5'-end of the poliovirus genome functions as a general promoter for RNA synthesis
author: Vogt, D.A.
author: Andino, R.
journal: PLoS Pathog. 6 (6), E1000936 (2010)
pubmed: 20532207
comments: Publication Status: Online-Only

20532207
type: PubMed
SIO_000068: pubmed

3
title: Replication of poliovirus requires binding of the poly(rC) binding protein to the cloverleaf as well as to the adjacent C-rich spacer sequence between the cloverleaf and the internal ribosomal entry site
author: Toyoda, H.
author: Franco, D.
author: Fujita, K.
author: Paul, A.V.
author: Wimmer, E.
journal: J. Virol.
volume: 81
issue: 18
pages: 10017-10028
year: 2007
pubmed: 17609276

17609276
type: PubMed
SIO_000068: pubmed

4
title: Interaction of translation initiation factor eIF4B with the poliovirus internal ribosome entry site
author: Ochs, K.
author: Saleh, L.
author: Bassili, G.
author: Sonntag, V.H.
author: Zeller, A.
author: Niepmann, M.
journal: J. Virol.
volume: 76
issue: 5
pages: 2113-2122
year: 2002
pubmed: 11836388

11836388
type: PubMed
SIO_000068: pubmed

5
title: Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase
author: Parsley, T.B.
author: Towner, J.S.
author: Blyn, L.B.
author: Ehrenfeld, E.
author: Semler, B.L.
journal: RNA
volume: 3
issue: 10
pages: 1124-1134
year: 1997
pubmed: 9326487

9326487
type: PubMed
SIO_000068: pubmed

6
title: Cis-element, oriR, involved in the initiation of (-) strand poliovirus RNA: a quasi-globular multi-domain RNA structure maintained by tertiary ('kissing') interactions
author: Pilipenko, E.V.
author: Poperechny, K.V.
author: Maslova, S.V.
author: Melchers, W.J.
author: Slot, H.J.
author: Agol, V.I.
journal: EMBO J.
volume: 15
issue: 19
pages: 5428-5436
year: 1996
pubmed: 8895586

8895586
type: PubMed
SIO_000068: pubmed

7
title: Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry
author: Blyn, L.B.
author: Swiderek, K.M.
author: Richards, O.
author: Stahl, D.C.
author: Semler, B.L.
author: Ehrenfeld, E.
journal: Proc. Natl. Acad. Sci. U.S.A.
volume: 93
issue: 20
pages: 11115-11120
year: 1996
pubmed: 8855318

8855318
type: PubMed
SIO_000068: pubmed

8
title: The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region
author: Hellen, C.U.
author: Pestova, T.V.
author: Litterst, M.
author: Wimmer, E.
journal: J. Virol.
volume: 68
issue: 2
pages: 941-950
year: 1994
pubmed: 8289396

8289396
type: PubMed
SIO_000068: pubmed

9
title: Minimum internal ribosome entry site required for poliovirus infectivity
author: Haller, A.A.
author: Nguyen, J.H.
author: Semler, B.L.
journal: J. Virol.
volume: 67
issue: 12
pages: 7461-7471
year: 1993
pubmed: 8230467

8230467
type: PubMed
SIO_000068: pubmed

10
title: Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA
author: Andino, R.
author: Rieckhof, G.E.
author: Achacoso, P.L.
author: Baltimore, D.
journal: EMBO J.
volume: 12
issue: 9
pages: 3587-3598
year: 1993
pubmed: 8253083

8253083
type: PubMed
SIO_000068: pubmed

11
title: Towards identification of cis-acting elements involved in the replication of enterovirus and rhinovirus RNAs: a proposal for the existence of tRNA-like terminal structures
author: Pilipenko, E.V.
author: Maslova, S.V.
author: Sinyakov, A.N.
author: Agol, V.I.
journal: Nucleic Acids Res.
volume: 20
issue: 7
pages: 1739-1745
year: 1992
pubmed: 1315956

1315956
type: PubMed
SIO_000068: pubmed

12
title: Intracellular modifications induced by poliovirus reduce the requirement for structural motifs in the 5' noncoding region of the genome involved in internal initiation of protein synthesis
author: Percy, N.
author: Belsham, G.J.
author: Brangwyn, J.K.
author: Sullivan, M.
author: Stone, D.M.
author: Almond, J.W.
journal: J. Virol.
volume: 66
issue: 3
pages: 1695-1701
year: 1992
pubmed: 1310772

1310772
type: PubMed
SIO_000068: pubmed

13
title: Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies
author: Nicholson, R.
author: Pelletier, J.
author: Le, S.Y.
author: Sonenberg, N.
journal: J. Virol.
volume: 65
issue: 11
pages: 5886-5894
year: 1991
pubmed: 1656077

1656077
type: PubMed
SIO_000068: pubmed

14
title: A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA
author: Andino, R.
author: Rieckhof, G.E.
author: Baltimore, D.
journal: Cell
volume: 63
issue: 2
pages: 369-380
year: 1990
pubmed: 2170027

2170027
type: PubMed
SIO_000068: pubmed

15
title: A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation
author: Jang, S.K.
author: Krausslich, H.G.
author: Nicklin, M.J.
author: Duke, G.M.
author: Palmenberg, A.C.
author: Wimmer, E.
journal: J. Virol.
volume: 62
issue: 8
pages: 2636-2643
year: 1988
pubmed: 2839690

2839690
type: PubMed
SIO_000068: pubmed

16
title: Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
author: Pelletier, J.
author: Sonenberg, N.
journal: Nature
volume: 334
issue: 6180
pages: 320-325
year: 1988
pubmed: 2839775

2839775
type: PubMed
SIO_000068: pubmed

17
title: In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate
author: Dorner, A.J.
author: Semler, B.L.
author: Jackson, R.J.
author: Hanecak, R.
author: Duprey, E.
author: Wimmer, E.
journal: J. Virol.
volume: 50
issue: 2
pages: 507-514
year: 1984
pubmed: 6323749

6323749
type: PubMed
SIO_000068: pubmed

18
title: Identification of the initiation site of poliovirus polyprotein synthesis
author: Dorner, A.J.
author: Dorner, L.F.
author: Larsen, G.R.
author: Wimmer, E.
author: Anderson, C.W.
journal: J. Virol.
volume: 42
issue: 3
pages: 1017-1028
year: 1982
pubmed: 6284987

6284987
type: PubMed
SIO_000068: pubmed

19
title: Carboxy-terminal analysis of poliovirus proteins: termination of poliovirus RNA translation and location of unique poliovirus polyprotein cleavage sites
author: Emini, E.A.
author: Elzinga, M.
author: Wimmer, E.
journal: J. Virol.
volume: 42
issue: 1
pages: 194-199
year: 1982
pubmed: 6283138

6283138
type: PubMed
SIO_000068: pubmed

20
title: Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome
author: Racaniello, V.R.
author: Baltimore, D.
journal: Proc. Natl. Acad. Sci. U.S.A.
volume: 78
issue: 8
pages: 4887-4891
year: 1981
pubmed: 6272282

6272282
type: PubMed
SIO_000068: pubmed

21
title: Primary structure, gene organization and polypeptide expression of poliovirus RNA
author: Kitamura, N.
author: Semler, B.L.
author: Rothberg, P.G.
author: Larsen, G.R.
author: Adler, C.J.
author: Dorner, A.J.
author: Emini, E.A.
author: Hanecak, R.
author: Lee, J.J.
author: van der Werf, S.
author: Anderson, C.W.
author: Wimmer, E.
journal: Nature
volume: 291
issue: 5816
pages: 547-553
year: 1981
pubmed: 6264310

6264310
type: PubMed
SIO_000068: pubmed

22
title: The genome-linked protein of picornaviruses. VII. Genetic mapping of poliovirus VPg by protein and RNA sequence studies
author: Kitamura, N.
author: Adler, C.J.
author: Rothberg, P.G.
author: Martinko, J.
author: Nathenson, S.G.
author: Wimmer, E.
journal: Cell
volume: 21
issue: 1
pages: 295-302
year: 1980
pubmed: 6250717

6250717
type: PubMed
SIO_000068: pubmed

23
title: Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as determined by a modification of the dideoxynucleotide method
author: Kitamura, N.
author: Wimmer, E.
journal: Proc. Natl. Acad. Sci. U.S.A.
volume: 77
issue: 6
pages: 3196-3200
year: 1980
pubmed: 6158042

6158042
type: PubMed
SIO_000068: pubmed

24
title: Direct Submission
journal: Submitted (01-AUG-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7440:1
position: 7440
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-7440:1:source
so part of: sequence
organism: Enterovirus C
mol type: genomic RNA
strain: Human poliovirus 1 Mahoney

138950
type: Taxonomy
SIO_000068: taxonomy

5'UTR
type: Five Prime UTR
subclass of: SO_0000204
RO_0002162: 138950
experiment: EXISTENCE:[6264310 ]
function: The 5' non-translated region (NTR) harbors two functional domains, the cloverleaf and the internal ribosome entry site (IRES), and is covalently linked to the viral protein VPg.
so part of: sequence
location: 1..742
location: region:1-742:1
so has part: feature:1-742:1:region

position:742:1
position: 742
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-742:1:region

ncRNA
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 138950
nc RNA class: other
product: stem-loop I (cloverleaf site)
experiment: EXISTENCE:site-directed mutagenesis and chemical and RNAase probing[ 2170027; 1310772]
note: Contains binding site for cellular poly(rC) binding protein 2 (PCBP2). Essential for RNA replication and, hence, viral prolifiration.
so part of: sequence
location: 1..88
location: region:1-88:1
so has part: feature:1-88:1:region

position:88:1
position: 88
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-88:1:region

misc_structure
type: Miscellaneous Structure
subclass of: SO_0000002
RO_0002162: 138950
experiment: EXISTENCE:site-directed mutation[ 2170027; 20532207]
note: stem a
function: essential for the initiation of positive-strand RNA synthesis
so part of: sequence
location: join(2..8,82..88)
location: region:2-88:1
so has part: feature:2-8:1:region
so has part: feature:82-88:1:region

position:2:1
position: 2
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2-8:1:region

position:8:1
position: 8
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:82-88:1:region

position:82:1
position: 82
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
experiment: EXISTENCE: site-directed mutagenesis and the crystal structure of a related protease[ 8253083 ]
note: stem-loop b
function: binds poly(rC) binding protein 2 (PCBP2)
so part of: sequence
location: 10..34
location: region:10-34:1
so has part: feature:10-34:1:region

position:10:1
position: 10
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:34:1
position: 34
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:10-34:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
experiment: EXISTENCE:induced mutagenesis and deletion analysis[8230467]
note: stem-loop c
function: involved in poliomavirus translation initiation and probably one of internal ribosome entry sites (IRES)
so part of: sequence
location: 35..45
location: region:35-45:1
so has part: feature:35-45:1:region

position:35:1
position: 35
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:45:1
position: 45
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:35-45:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
experiment: EXISTENCE:mutational analysis[ 8253083; 2170027; 9326487]
note: stem-loop d
function: specifically interact with the viral proteinase and RNA binding protein 3CD pro
so part of: sequence
location: 51..78
location: region:51-78:1
so has part: feature:51-78:1:region

position:51:1
position: 51
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:78:1
position: 78
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:51-78:1:region

ncRNA
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 138950
nc RNA class: other
product: spacer
experiment: EXISTENCE:[17609276]
note: Contains C-rich region, nt 89-95, which is required for PCBP (cellular poly(C) binding proteins) to function as an essential cofactor in poliovirus genome.
so part of: sequence
location: 89..122
location: region:89-122:1
so has part: feature:89-122:1:region

position:89:1
position: 89
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:122:1
position: 122
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:89-122:1:region

ncRNA
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 138950
nc RNA class: other
product: internal ribosome entry site (IRES)
experiment: EXISTENCE:immunoprecipitation, time course, and N-formyl-[35S]methionine labeling
note: IRES mediates cap-independent translation of the viral mRNA by facilitating initiation of translation independent of a capping group and a free 5' end.
so part of: sequence
location: 123..619
location: region:123-619:1
so has part: feature:123-619:1:region

position:123:1
position: 123
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:619:1
position: 619
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123-619:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
note: stem-loop II
function: interacts with pyrimidine tract-binding protein (PTB)
so part of: sequence
location: 123..161
location: region:123-161:1
so has part: feature:123-161:1:region

position:161:1
position: 161
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123-161:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
note: stem-loop III
function: Essential for internal initiation of translation (showed experimentaly for Poliovirus 2).
so part of: sequence
location: 185..220
location: region:185-220:1
so has part: feature:185-220:1:region

position:185:1
position: 185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:220:1
position: 220
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185-220:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
experiment: EXISTENCE:automated liquid chromatography-tandem mass spectrometry[8855318]
note: stem-loop IV
function: binds with poly(rC) binding protein 2 (PCBP2)
so part of: sequence
location: 233..440
location: region:233-440:1
so has part: feature:233-440:1:region

position:233:1
position: 233
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:440:1
position: 440
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:233-440:1:region

conflict
type: nucleotide
subclass of: obo
RO_0002162: 138950
note: CGCUC is GUU in [3]
citation: [21]
so part of: sequence
location: 284..288
location: region:284-288:1
so has part: feature:284-288:1:region

position:284:1
position: 284
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:288:1
position: 288
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:284-288:1:region

conflict
type: nucleotide
subclass of: obo
RO_0002162: 138950
note: G is U in [3]
citation: [21]
so part of: sequence
location: 352
location: region:352-352:1
so has part: feature:352-352:1:region

position:352:1
position: 352
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352-352:1:region

conflict
type: nucleotide
subclass of: obo
RO_0002162: 138950
note: GC is C in [3]
citation: [21]
so part of: sequence
location: 387
location: region:387-387:1
so has part: feature:387-387:1:region

position:387:1
position: 387
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387-387:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
experiment: EXISTENCE:The tethered hydroxyl-radical probing assays coupled with the mass spectrometry data.[20859255]
note: stem-loop V
function: Stem-loop V binds single polypyrimidine tract-binding protein (PTB) in a unique orientation. PTB RNA-binding domains (RBDs) 1 and 2 interact with the basal part of Domain V, and RBDs3 and 4 binding the putatively single-stranded linkers flanking Domain V. This stimulates IRES activity by inducing eukaryotic translation initiation factor 4 gammaprotein (eIF4G) to bind in the optimal position and orientation to promote internal ribosome entry.
so part of: sequence
location: 448..556
location: region:448-556:1
so has part: feature:448-556:1:region

position:448:1
position: 448
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:556:1
position: 556
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448-556:1:region

conflict
type: nucleotide
subclass of: obo
RO_0002162: 138950
note: G is GU in [3]
citation: [21]
so part of: sequence
location: 488
location: region:488-488:1
so has part: feature:488-488:1:region

position:488:1
position: 488
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488-488:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
note: stem-loop VI
function: interacts with translation initiation factor 4 gammaprotein (eIF4G).
so part of: sequence
location: 581..618
location: region:581-618:1
so has part: feature:581-618:1:region

position:581:1
position: 581
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:618:1
position: 618
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:581-618:1:region

PVgp1
type: Gene
subclass of: SO_0000704
RO_0002162: 138950
locus tag: PVgp1
so part of: sequence
location: 743..7372
location: region:743-7372:1
so has part: feature:743-7372:1:exon
subclass of: SO_0000010

919920
type: Gene
SIO_000068: ncbigene

position:743:1
position: 743
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7372:1
position: 7372
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:743-7372:1:exon

PVgp1
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 138950
locus tag: PVgp1
experiment: EXISTENCE:[6264310]
note: The polyprotein contains structural (P1) and non-structural (P2 and P3) proteins that are released from the polypeptide chain by proteolytic processing mediated by virally-encoded proteinases 2A pro and 3C pro/3CD pro to ultimately generate eleven mature viral proteins
codon start: 1
product: genome polyprotein
translation: MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSDRVLQLTLGNSTITTQEAANSVVAYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGLFGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGTFTPDNNQTSPARRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITLTIAPMCCEFNGLRNITLPRLQGLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDDPILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGFMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGLQSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQGLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESFFARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYVPPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGILAVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTYGFGHQNKAVYTAGYKICNYHLATQDDLQNAVNVMWSRDLLVTESRAQGTDSIARCNCNAGVYYCESRRKYYPVSFVGPTFQYMEANNYYPARYQSHMLIGHGFASPGDCGGILRCHHGVIGIITAGGEGLVAFSDIRDLYAYEEEAMEQGITNYIESLGAAFGSGFTQQISDKITELTNMVTSTITEKLLKNLIKIISSLVIITRNYEDTTTVLATLALLGCDASPWQWLRKKACDVLEIPYVIKQGDSWLKKFTEACNAAKGLEWVSNKISKFIDWLKEKIIPQARDKLEFVTKLRQLEMLENQISTIHQSCPSQEHQEILFNNVRWLSIQSKRFAPLYAVEAKRIQKLEHTINNYIQFKSKHRIEPVCLLVHGSPGTGKSVATNLIARAIAERENTSTYSLPPDPSHFDGYKQQGVVIMDDLNQNPDGADMKLFCQMVSTVEFIPPMASLEEKGILFTSNYVLASTNSSRISPPTVAHSDALARRFAFDMDIQVMNEYSRDGKLNMAMATEMCKNCHQPANFKRCCPLVCGKAIQLMDKSSRVRYSIDQITTMIINERNRRSNIGNCMEALFQGPLQYKDLKIDIKTSPPPECINDLLQAVDSQEVRDYCEKKGWIVNITSQVQTERNINRAMTILQAVTTFAAVAGVVYVMYKLFAGHQGAYTGLPNKKPNVPTIRTAKVQGPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGESIVIDGKEVEILDAKALEDQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQCGGVITCTGKVIGMHVGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDFEEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQMCLEDAMYGTDGLEALDLSTSAGYPYVAMGKKKRDILNKQTRDTKEMQKLLDTYGINLPLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMRMAFGNLYAAFHKNPGVITGSAVGCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFEALKMV…
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 743..7372
location: region:743-7372:1
so has part: feature:743-7372:1:exon

NP_041277.1
type: Protein
SIO_000068: ncbiprotein

P03300
type: GOA
SIO_000068: goa

P03300
type: UniProt
SIO_000068: uniprot

urn:…
SIO_000300: 1
SIO_000628: feature:743-7372:1:exon

PVgp1
type: Feature
subclass of: SO_0000001
RO_0002162: 138950
locus tag: PVgp1
product: precursor polypeptide P1
experiment: EXISTENCE:Amino acid sequence analysis cleavage products of the polyprotein.[6264310]
note: Precursor of structural proteins. 3CDpro cleaves the P1 precursor polypeptide, giving rise to proteins VP0, VP3 and VP1.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 746..3385
location: region:746-3385:1
so has part: feature:746-3385:1:exon

position:746:1
position: 746
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:3385:1
position: 3385
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:746-3385:1:exon

PVgp1
type: Feature
subclass of: SO_0000001
RO_0002162: 138950
locus tag: PVgp1
product: capsid protein VP0
experiment: EXISTENCE:[6264310]
note: Precursor of VP4 and VP2 capsid proteins. Cleavage of VP0 into capsid proteins VP4 and VP2 occurs during maturation of the virion.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 746..1765
location: region:746-1765:1
so has part: feature:746-1765:1:exon

position:1765:1
position: 1765
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:746-1765:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: capsid protein VP4
experiment: EXISTENCE:x-ray crystallographic methods
note: Poliovirus capsid is formed from 60 copies of 4 coat protein subunits (VP1, VP2, VP3 and VP4). VP1, VP2 and VP3 are the major capsid proteins forming the icosahedral capsid shell (T=3), with a diameter of approximately 300 Angstroms. Each of them contains a 'core' consisting of an eight-stranded antiparallel beta barrel with two flanking helices. The capsid protects the viral genome from the environment, and facilitates delivery to appropriate target cells (by binding to the specific poliovirus receptor, PVR). As infection begins, viral RNA must be freed from the capsid during the 'uncoating' process and penetrate the cell. VP4 protein lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. Externalization of VP4 (together with N terminus of VP1 and shifts of the capsid beta barrels) initiates irreversible conformational change to the 135S particles ('A' particles) cell entry intermediate. It seems that Poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process. PVR mediates virus attachment to target cells, initiates the uncoating process and inducts intracellular signals for virus entry.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 746..949
location: region:746-949:1
so has part: feature:746-949:1:exon

NP_740468.1
type: Protein
SIO_000068: ncbiprotein

position:949:1
position: 949
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:746-949:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: capsid protein VP2
experiment: EXISTENCE:x-ray crystallographic methods[2994218]
note: See the comment for coat protein VP4.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 950..1765
location: region:950-1765:1
so has part: feature:950-1765:1:exon

NP_740469.1
type: Protein
SIO_000068: ncbiprotein

position:950:1
position: 950
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:950-1765:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: capsid protein VP3
experiment: EXISTENCE:x-ray crystallographic methods[ 2994218]
note: See the comment for coat protein VP4.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1766..2479
location: region:1766-2479:1
so has part: feature:1766-2479:1:exon

NP_740470.1
type: Protein
SIO_000068: ncbiprotein

position:1766:1
position: 1766
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2479:1
position: 2479
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1766-2479:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: capsid protein VP1
experiment: EXISTENCE: x-ray crystallographic methods[2994218]
note: See the comment for coat protein VP4.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2480..3385
location: region:2480-3385:1
so has part: feature:2480-3385:1:exon

NP_740471.1
type: Protein
SIO_000068: ncbiprotein

position:2480:1
position: 2480
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2480-3385:1:exon

PVgp1
type: Feature
subclass of: SO_0000001
RO_0002162: 138950
locus tag: PVgp1
product: precursor polypeptide P2
experiment: EXISTENCE:Amino acid sequence analysis and were found to be proteolytic cleavage products of the polyprotein.[6264310]
note: P2 precursor polypeptide is a precursor of nonstructural proteins, which is released from the polypeptide chain by proteolytic processing mediated by virally-encoded proteinases 2A pro to ultimately 3 mature viral proteins: 2A, 2B and 2C. P2 proteins are primarily responsible for the biochemical and structural changes that occur in the infected cell.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3386..5110
location: region:3386-5110:1
so has part: feature:3386-5110:1:exon

position:3386:1
position: 3386
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5110:1
position: 5110
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3386-5110:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protease 2A
experiment: EXISTENCE:protein expression[3011278]
note: Picornain 2A (Protein 2A) is a small chymotrypsin-like cysteine proteinase. It is responsible for the cleavage between the P1 and P2 regions. In order to shut down the capped cellular mRNA transcription, picornain 2A cleaves the host translation initiation factor EIF4G1 and induces apoptotic cell death.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3386..3832
location: region:3386-3832:1
so has part: feature:3386-3832:1:exon

NP_740477.1
type: Protein
SIO_000068: ncbiprotein

position:3832:1
position: 3832
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3386-3832:1:exon

PVgp1
type: Feature
subclass of: SO_0000001
RO_0002162: 138950
locus tag: PVgp1
product: protein 2BC
experiment: EXISTENCE:protein expression[3011278]
note: Processing of 2BC by 3Cpro gives rise to the mature products 2B and 2C, although a large fraction of 2BC remains uncleaved in picornavirus-infected cells. The expression of poliovirus 2BC protein in yeast and mammalian cells leads to a number of metabolic and morphological alterations, such as growth inhibition, intracellular membrane proliferation, blockade of the exocytic pathway, and enhanced membrane permeability.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3833..5110
location: region:3833-5110:1
so has part: feature:3833-5110:1:exon

position:3833:1
position: 3833
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3833-5110:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protein 2B
experiment: EXISTENCE:protein expression[3011278]
note: Protein 2B enhances membrane permeability.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3833..4123
location: region:3833-4123:1
so has part: feature:3833-4123:1:exon

NP_740472.1
type: Protein
SIO_000068: ncbiprotein

position:4123:1
position: 4123
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3833-4123:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protein 2C
experiment: EXISTENCE:protein expression[3011278]
note: Involved in initiation and elongation of RNA synthesis, RNA encapsidation, virus uncoating and guanidine resistance (Asn179-Gly mutation). Putative helicase III.~2C protein (together with 2BC protein) induces the formation of host cell endoplasmic reticulum-derived rosette-like membranous structures, located in the cytoplasm, where the process of viral RNA replication takes place.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 4124..5110
location: region:4124-5110:1
so has part: feature:4124-5110:1:exon

NP_740473.1
type: Protein
SIO_000068: ncbiprotein

position:4124:1
position: 4124
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4124-5110:1:exon

PVgp1
type: Feature
subclass of: SO_0000001
RO_0002162: 138950
locus tag: PVgp1
product: precursor polypeptide P3
experiment: EXISTENCE:Amino acid sequence analysis cleavage products of the polyprotein.[6264310]
note: Processing of the P3 precursor occurs by two independent pathways, major and minor. In the major pathway, processing between 3B and 3C yields 3AB and 3CD. In the minor pathway, processing between 3A and 3B yields 3A and 3BCD. 3BCD processing yields 3BC and 3D; 3BC processing yields 3B and 3C.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5111..7369
location: region:5111-7369:1
so has part: feature:5111-7369:1:exon

position:5111:1
position: 5111
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7369:1
position: 7369
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5111-7369:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protein 3AB
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting. [18779320]
note: Poliovirus protein 3AB displayes nucleic acid chaperone activity in promoting the hybridization of complementary nucleic acids and destabilizing secondary structure. It also stimulates the rate of binding between complementary nucleic acid, demonstrates helix-destabilizing activity, and serves as a donor for VPg uridylylation.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5111..5437
location: region:5111-5437:1
so has part: feature:5111-5437:1:exon

YP_007353733.1
type: Protein
SIO_000068: ncbiprotein

position:5437:1
position: 5437
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5111-5437:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protein 3A
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting. [18779320]
note: Poliovirus protein 3A is a small, membrane-binding protein that plays multiple roles in viral RNA replication complex formation and function. In the infected cell, this protein associates with other viral and cellular proteins as part of a supramolecular complex.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5111..5371
location: region:5111-5371:1
so has part: feature:5111-5371:1:exon

NP_740474.1
type: Protein
SIO_000068: ncbiprotein

position:5371:1
position: 5371
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5111-5371:1:exon

PVgp1
type: Feature
subclass of: SO_0000001
RO_0002162: 138950
locus tag: PVgp1
product: precursor protein 3BCD
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting.[18779320]
note: 3BCD precursor protein is a precursor of 3BC and 3D proteins. Uncleaved precursor 3BCD is one of the substrates for uridylylation of VPg protein.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5372..7369
location: region:5372-7369:1
so has part: feature:5372-7369:1:exon

position:5372:1
position: 5372
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5372-7369:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: viral protein genome-linked
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting. [18779320]
note: VPg (3B), a small protein that binds viral RNA and is necessary for synthesis of viral positive and negative strand RNA.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5372..5437
location: region:5372-5437:1
so has part: feature:5372-5437:1:exon

NP_740475.1
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:5372-5437:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protein 3CD
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting. [18779320]
note: 3CD protein lacks polymerase activity, but possesses protease activity with substrate recognition properties distinct from those of 3C protein. It was shown that cleavage of the viral capsid proteins, located in the N-terminal portion of the poliovirus polyprotein, requires 3CD-catalyzed proteolysis. 3CD protease activity has been implicated in cleavage of several host proteins. In addition to its proteolytic activities, 3CD also involved in viral RNA replication process. The protein binds to the cloverleaf structure at the 5? terminus of poliovirus RNA, and this binding was shown to be important for virus replication. 3CD also stimulates uridylylation of viral protein VPg, catalyzed by 3D, which is required for initiation of RNA replication, by binding to the template for uridylylation on the cis-acting replication element. 3CD protein interacts with the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) C1/C2, which forms a specific RNP complex with the poliovirus 3? nontranslated region that is thought to be important for replication. 3CD (as well as another poliovirus protein, 3A), induces the recruitment to membranes of cellular proteins from the family of small GTPases, designated Arfs (ADP ribosylation factors).
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5438..7369
location: region:5438-7369:1
so has part: feature:5438-7369:1:exon

YP_007353734.1
type: Protein
SIO_000068: ncbiprotein

position:5438:1
position: 5438
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5438-7369:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: protease 3C
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting.[18779320]
note: Chymotrypsin-like cystein proteinase 3C. Viral 3C protease (3Cpro) plays a major role in translation regulation. It cleaves poly(A)-binding protein (PABP) and removes the C-terminal domain (CTD) that interacts with several translation factors. 3C protein has been shown to function as a stimulatory factor for 3Dpol in the VPg uridylylation reaction.
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5438..5986
location: region:5438-5986:1
so has part: feature:5438-5986:1:exon

NP_740476.2
type: Protein
SIO_000068: ncbiprotein

position:5986:1
position: 5986
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5438-5986:1:exon

PVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 138950
locus tag: PVgp1
product: RNA-directed RNA polymerase
experiment: EXISTENCE:Poliovirus polyprotein processing by the Gly-Gly mutant evaluated by Western blotting. [18779320]
note: 3D; The RNA-dependent RNA-polymerase, 3Dpol, is an essential component in genome for the replication of single stranded RNA. 3Dpol catalyze two independend half-reactions leading to the attachment of VPg protein to the 5' end of viral RNA. First, VPg is uridylylated to produce VPg-pUpU; second, VPg-pUpU serves as a primer for full-length RNA synthesis
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5987..7369
location: region:5987-7369:1
so has part: feature:5987-7369:1:exon

NP_740478.2
type: Protein
SIO_000068: ncbiprotein

position:5987:1
position: 5987
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5987-7369:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: GG is G in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1467..1468
location: region:1467-1468:1
so has part: feature:1467-1468:1:exon

position:1467:1
position: 1467
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1468:1
position: 1468
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1467-1468:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: CC is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1529..1530
location: region:1529-1530:1
so has part: feature:1529-1530:1:exon

position:1529:1
position: 1529
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1530:1
position: 1530
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1529-1530:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: CC is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1534..1535
location: region:1534-1535:1
so has part: feature:1534-1535:1:exon

position:1534:1
position: 1534
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1535:1
position: 1535
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1534-1535:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is U in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1547
location: region:1547-1547:1
so has part: feature:1547-1547:1:exon

position:1547:1
position: 1547
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1547-1547:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is A in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1579
location: region:1579-1579:1
so has part: feature:1579-1579:1:exon

position:1579:1
position: 1579
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1579-1579:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1601
location: region:1601-1601:1
so has part: feature:1601-1601:1:exon

position:1601:1
position: 1601
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1601-1601:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is U in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 1668
location: region:1668-1668:1
so has part: feature:1668-1668:1:exon

position:1668:1
position: 1668
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1668-1668:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2001
location: region:2001-2001:1
so has part: feature:2001-2001:1:exon

position:2001:1
position: 2001
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2001-2001:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: AUC is CCU in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2004..2006
location: region:2004-2006:1
so has part: feature:2004-2006:1:exon

position:2004:1
position: 2004
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2006:1
position: 2006
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2004-2006:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: U is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2035
location: region:2035-2035:1
so has part: feature:2035-2035:1:exon

position:2035:1
position: 2035
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2035-2035:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: U is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2133
location: region:2133-2133:1
so has part: feature:2133-2133:1:exon

position:2133:1
position: 2133
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2133-2133:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is G in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2286
location: region:2286-2286:1
so has part: feature:2286-2286:1:exon

position:2286:1
position: 2286
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2286-2286:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: G is A in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 2983
location: region:2983-2983:1
so has part: feature:2983-2983:1:exon

position:2983:1
position: 2983
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2983-2983:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is G in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3043
location: region:3043-3043:1
so has part: feature:3043-3043:1:exon

position:3043:1
position: 3043
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3043-3043:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: GG is G in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3303..3304
location: region:3303-3304:1
so has part: feature:3303-3304:1:exon

position:3303:1
position: 3303
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:3304:1
position: 3304
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3303-3304:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: G is GC in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3308
location: region:3308-3308:1
so has part: feature:3308-3308:1:exon

position:3308:1
position: 3308
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3308-3308:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is U in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3657
location: region:3657-3657:1
so has part: feature:3657-3657:1:exon

position:3657:1
position: 3657
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3657-3657:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is A in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3696
location: region:3696-3696:1
so has part: feature:3696-3696:1:exon

position:3696:1
position: 3696
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3696-3696:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is A in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 3766
location: region:3766-3766:1
so has part: feature:3766-3766:1:exon

position:3766:1
position: 3766
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3766-3766:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is CC in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 4158
location: region:4158-4158:1
so has part: feature:4158-4158:1:exon

position:4158:1
position: 4158
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4158-4158:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: GC is G in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 4163..4164
location: region:4163-4164:1
so has part: feature:4163-4164:1:exon

position:4163:1
position: 4163
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:4164:1
position: 4164
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4163-4164:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 4174
location: region:4174-4174:1
so has part: feature:4174-4174:1:exon

position:4174:1
position: 4174
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4174-4174:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5113
location: region:5113-5113:1
so has part: feature:5113-5113:1:exon

position:5113:1
position: 5113
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5113-5113:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: U is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5598
location: region:5598-5598:1
so has part: feature:5598-5598:1:exon

position:5598:1
position: 5598
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5598-5598:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: CGCUC is UGUUU in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5619..5623
location: region:5619-5623:1
so has part: feature:5619-5623:1:exon

position:5619:1
position: 5619
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5623:1
position: 5623
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5619-5623:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is U in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5645
location: region:5645-5645:1
so has part: feature:5645-5645:1:exon

position:5645:1
position: 5645
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5645-5645:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: G is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5786
location: region:5786-5786:1
so has part: feature:5786-5786:1:exon

position:5786:1
position: 5786
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5786-5786:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: AAA is AA in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5903..5905
location: region:5903-5905:1
so has part: feature:5903-5905:1:exon

position:5903:1
position: 5903
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5905:1
position: 5905
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5903-5905:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: GGGAA is GGA in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5927..5931
location: region:5927-5931:1
so has part: feature:5927-5931:1:exon

position:5927:1
position: 5927
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5931:1
position: 5931
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5927-5931:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: AC is UA in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5970..5971
location: region:5970-5971:1
so has part: feature:5970-5971:1:exon

position:5970:1
position: 5970
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5971:1
position: 5971
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5970-5971:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 5997
location: region:5997-5997:1
so has part: feature:5997-5997:1:exon

position:5997:1
position: 5997
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5997-5997:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: A is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 6019
location: region:6019-6019:1
so has part: feature:6019-6019:1:exon

position:6019:1
position: 6019
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6019-6019:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: U is C in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 6021
location: region:6021-6021:1
so has part: feature:6021-6021:1:exon

position:6021:1
position: 6021
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6021-6021:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: C is U in [3]
citation: [21]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 6261
location: region:6261-6261:1
so has part: feature:6261-6261:1:exon

position:6261:1
position: 6261
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6261-6261:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: CCA is CA in [2]
citation: [22]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 6845..6847
location: region:6845-6847:1
so has part: feature:6845-6847:1:exon

position:6845:1
position: 6845
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6847:1
position: 6847
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6845-6847:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: UU is UUU in [2]
citation: [22]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 6978..6979
location: region:6978-6979:1
so has part: feature:6978-6979:1:exon

position:6978:1
position: 6978
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6979:1
position: 6979
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6978-6979:1:exon

PVgp1
type: nucleotide
subclass of: obo
RO_0002162: 138950
locus tag: PVgp1
note: U is UU in [2]
citation: [22]
SIO_010081: PVgp1
subclass of: SO_0000673
so part of: PVgp1
location: 7258
location: region:7258-7258:1
so has part: feature:7258-7258:1:exon

position:7258:1
position: 7258
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7258-7258:1:exon

ncRNA
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 138950
nc RNA class: other
experiment: EXISTENCE:chemical sequencing[6264310 ]
note: The genomic RNA 3' noncoding region is believed to be a major cis-acting molecular genetic determinant for regulating picornavirus negative-strand RNA synthesis by promoting replication complex recognition. This region predicted to exhibit conserved secondary structures consisting of two stem-loops: X and Y. Furthermore, a proposed tertiary 'kissing' interaction involving base pairing between the loop regions of stem-loops X and Y was suggested.
so part of: sequence
location: 7370..7440
location: region:7370-7440:1
so has part: feature:7370-7440:1:region

position:7370:1
position: 7370
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7370-7440:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
note: stem-loop Y
so part of: sequence
location: 7374..7417
location: region:7374-7417:1
so has part: feature:7374-7417:1:region

position:7374:1
position: 7374
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7417:1
position: 7417
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7374-7417:1:region

conflict
type: nucleotide
subclass of: obo
RO_0002162: 138950
note: U is C in [3] and [2]
citation: [21]
citation: [22]
so part of: sequence
location: 7410
location: region:7410-7410:1
so has part: feature:7410-7410:1:region

position:7410:1
position: 7410
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7410-7410:1:region

stem_loop
type: Stem Loop
subclass of: SO_0000313
RO_0002162: 138950
note: stem-loop X
so part of: sequence
location: 7423..7440
location: region:7423-7440:1
so has part: feature:7423-7440:1:region

position:7423:1
position: 7423
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7423-7440:1:region

conflict
type: nucleotide
subclass of: obo
RO_0002162: 138950
note: G is GG in [3] and [2]
citation: [21]
citation: [22]
so part of: sequence
location: 7440
location: region:7440-7440:1
so has part: feature:7440-7440:1:region

urn:…
SIO_000300: 1
SIO_000628: feature:7440-7440:1:region