Enterococcus faecium strain SRR24 plasmid pSRR24.
Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus.
Tandem amplification of the vanM gene cluster drives vancomycin resistance in vancomycin-variable enterococci
Submitted (28-MAR-2019) College of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, Zhejiang Province 310016, China
Submitted (20-FEB-2019) College of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, Zhejiang Province 310016, China
REFSEQ INFORMATION: The reference sequence is identical to\nCP038997.1.\nThe annotation was added by the NCBI Prokaryotic Genome Annotation\nPipeline (PGAP). Information about PGAP can be found here:\nhttps://www.ncbi.nlm.nih.gov/genome/annotation_prok/\n\n##Genome-Assembly-Data-START##\nAssembly Method :: Unicycler v. DEC-2018\nGenome Representation :: Full\nExpected Final Version :: Yes\nGenome Coverage :: 403.0x\nSequencing Technology :: Oxford Nanopore MiniION\n##Genome-Assembly-Data-END##\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: NCBI RefSeq\nAnnotation Date :: 03/09/2023 09:11:03\nAnnotation Pipeline :: NCBI Prokaryotic Genome\n Annotation Pipeline (PGAP)\nAnnotation Method :: Best-placed reference protein\n set; GeneMarkS-2+\nAnnotation Software revision :: 6.4\nFeatures Annotated :: Gene; CDS; rRNA; tRNA; ncRNA\nGenes (total) :: 2,887\nCDSs (total) :: 2,795\nGenes (coding) :: 2,714\nCDSs (with protein) :: 2,714\nGenes (RNA) :: 92\nrRNAs :: 6, 6, 6 (5S, 16S, 23S)\ncomplete rRNAs :: 6, 6, 6 (5S, 16S, 23S)\ntRNAs :: 70\nncRNAs :: 4\nPseudo Genes (total) :: 81\nCDSs (without protein) :: 81\nPseudo Genes (ambiguous residues) :: 0 of 81\nPseudo Genes (frameshifted) :: 30 of 81\nPseudo Genes (incomplete) :: 47 of 81\nPseudo Genes (internal stop) :: 15 of 81\nPseudo Genes (multiple problems) :: 8 of 81\n##Genome-Annotation-Data-END##
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
COORDINATES: similar to AA sequence:RefSeq:WP_002320747.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
type II toxin-antitoxin system PemK/MazF family toxin
COORDINATES: similar to AA sequence:RefSeq:WP_005875251.1
GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]
type II toxin-antitoxin system RelB/DinJ family antitoxin
COORDINATES: similar to AA sequence:RefSeq:WP_002347514.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347513.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320752.1
COORDINATES: similar to AA sequence:RefSeq:WP_002361346.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320754.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320829.1
COORDINATES: similar to AA sequence:RefSeq:WP_002353409.1
COORDINATES: similar to AA sequence:RefSeq:WP_002335330.1
COORDINATES: similar to AA sequence:RefSeq:WP_016922296.1
GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA]
GO:0000373 - Group II intron splicing [Evidence IEA]
group II intron reverse transcriptase/maturase
COORDINATES: similar to AA sequence:RefSeq:WP_002352923.1
COORDINATES: ab initio prediction:GeneMarkS-2+
Derived by automated computational analysis using gene prediction method: GeneMarkS-2+.
COORDINATES: similar to AA sequence:RefSeq:WP_002347493.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321353.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321530.1
COORDINATES: similar to AA sequence:RefSeq:WP_002352925.1
COORDINATES: similar to AA sequence:RefSeq:WP_010730972.1
COORDINATES: similar to AA sequence:RefSeq:WP_010730973.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347498.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320840.1
COORDINATES: similar to AA sequence:RefSeq:WP_002349331.1
IS200/IS605 family element RNA-guided endonuclease TnpB
COORDINATES: similar to AA sequence:RefSeq:WP_002287522.1
IS200/IS605-like element ISEfa4 family transposase
COORDINATES: similar to AA sequence:RefSeq:WP_002320841.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320842.1
COORDINATES: similar to AA sequence:RefSeq:WP_002349960.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320844.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320845.1
RusA family crossover junction endodeoxyribonuclease
COORDINATES: similar to AA sequence:RefSeq:WP_002360376.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350574.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320848.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350576.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350577.1
GO:0004252 - serine-type endopeptidase activity [Evidence IEA]
rhomboid family intramembrane serine protease
COORDINATES: similar to AA sequence:RefSeq:WP_002347459.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350125.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320853.1
COORDINATES: similar to AA sequence:RefSeq:WP_002360380.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0003677 - DNA binding [Evidence IEA]; GO:0000166 - nucleotide binding [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002353145.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320856.1
COORDINATES: similar to AA sequence:RefSeq:WP_010729859.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347454.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320859.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347451.1
COORDINATES: similar to AA sequence:RefSeq:WP_010730978.1
COORDINATES: similar to AA sequence:RefSeq:WP_002352930.1
SpaA isopeptide-forming pilin-related protein
COORDINATES: similar to AA sequence:RefSeq:WP_002347449.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347448.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321214.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347446.1
COORDINATES: similar to AA sequence:RefSeq:WP_032495458.1
IS256-like element IS1542 family transposase
COORDINATES: similar to AA sequence:RefSeq:WP_016922277.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321012.1
COORDINATES: similar to AA sequence:RefSeq:WP_010782615.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347443.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321015.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347440.1
COORDINATES: similar to AA sequence:RefSeq:WP_064305258.1
GO:0004803 - transposase activity [Evidence IEA]
IS6-like element IS1216 family transposase
COORDINATES: similar to AA sequence:RefSeq:WP_000402347.1
GO:0016805 - dipeptidase activity [Evidence IEA]; GO:0008237 - metallopeptidase activity [Evidence IEA]
incomplete; partial in the middle of a contig; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
COORDINATES: similar to AA sequence:RefSeq:WP_001079845.1
COORDINATES: similar to AA sequence:RefSeq:WP_006285586.1
COORDINATES: similar to AA sequence:RefSeq:WP_006285584.1
frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.
VanY-A/VanY-F/VanY-M family D-Ala-D-Ala carboxypeptidase
COORDINATES: similar to AA sequence:RefSeq:WP_010282129.1
vancomycin resistance histidine kinase VanS-M
COORDINATES: similar to AA sequence:RefSeq:WP_006285581.1
vancomycin resistance response regulator transcription factor VanR-M
COORDINATES: similar to AA sequence:RefSeq:WP_002352868.1
COORDINATES: similar to AA sequence:RefSeq:WP_002352869.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321022.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347720.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321024.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321025.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347507.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350335.1
COORDINATES: similar to AA sequence:RefSeq:WP_002321028.1
COORDINATES: similar to AA sequence:RefSeq:WP_076611882.1
IS982-like element ISEfm1 family transposase
IS256-like element IS256 family transposase
COORDINATES: similar to AA sequence:RefSeq:WP_002316069.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320764.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320765.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320766.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350525.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320768.1
LPXTG cell wall anchor domain-containing protein
COORDINATES: similar to AA sequence:RefSeq:WP_002320769.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320771.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320772.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347433.1
GO:0005524 - ATP binding [Evidence IEA]; GO:0016887 - ATP hydrolysis activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_010782611.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320776.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320777.1
COORDINATES: similar to AA sequence:RefSeq:WP_016922497.1
GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]
GO:0006270 - DNA replication initiation [Evidence IEA]
RepB family plasmid replication initiator protein
COORDINATES: similar to AA sequence:RefSeq:WP_002320780.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320781.1
type II toxin-antitoxin system HicB family antitoxin
COORDINATES: similar to AA sequence:RefSeq:WP_002347532.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347533.1
COORDINATES: similar to AA sequence:RefSeq:WP_002349946.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320785.1
type II toxin-antitoxin system HicA family toxin
COORDINATES: similar to AA sequence:RefSeq:WP_002320786.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347535.1
COORDINATES: similar to AA sequence:RefSeq:WP_002347536.1
COORDINATES: similar to AA sequence:RefSeq:WP_002350541.1
COORDINATES: similar to AA sequence:RefSeq:WP_016922500.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320790.1
type II toxin-antitoxin system RelE/ParE family toxin
COORDINATES: similar to AA sequence:RefSeq:WP_002320791.1
COORDINATES: similar to AA sequence:RefSeq:WP_016922501.1
COORDINATES: similar to AA sequence:RefSeq:WP_002353124.1
COORDINATES: similar to AA sequence:RefSeq:WP_002351803.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0004803 - transposase activity [Evidence IEA]
GO:0006313 - transposition, DNA-mediated [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_016181188.1
GO:0016740 - transferase activity [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_002360115.1
COORDINATES: similar to AA sequence:RefSeq:WP_016615184.1
GO:0097367 - carbohydrate derivative binding [Evidence IEA]
GO:1901135 - carbohydrate derivative metabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_016181191.1
GO:0009025 - tagatose-bisphosphate aldolase activity [Evidence IEA]
GO:0019512 - lactose catabolic process via tagatose-6-phosphate [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_016181192.1
GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]
GO:0005975 - carbohydrate metabolic process [Evidence IEA]
COORDINATES: similar to AA sequence:RefSeq:WP_016181193.1
COORDINATES: similar to AA sequence:RefSeq:WP_016181194.1
COORDINATES: similar to AA sequence:RefSeq:WP_010746793.1
PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB
COORDINATES: similar to AA sequence:RefSeq:WP_002364095.1
COORDINATES: similar to AA sequence:RefSeq:WP_002311319.1
PTS system mannose/fructose/sorbose family transporter subunit IID
COORDINATES: similar to AA sequence:RefSeq:WP_003002366.1
COORDINATES: similar to AA sequence:RefSeq:WP_016181199.1
helix-turn-helix transcriptional regulator
COORDINATES: similar to AA sequence:RefSeq:WP_002320794.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320795.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320796.1
COORDINATES: similar to AA sequence:RefSeq:WP_002320797.1