Norovirus GV, complete genome.
type: Entry
definition: Norovirus GV, complete genome.
sequence version: NC_008311.1
sequence date: 2018-08-13
sequence: sequence
division: VRL
label: NC_008311.1
type: RefSeq
SIO_000068: refseq
dblink: PRJNA485481
keyword: RefSeq
source: Norovirus GV
organism: Norovirus GV
taxonomy: Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
reference: 1
references: 22174679
reference: 2
references: 16873239
reference: 3
references: 15562321
reference: 4
reference: 5
comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from DQ285629.\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000353
sequence length: 7382
topology: linear
so has quality: SO_0000987
location: 1..7382
location: region:1-7382:1
RO_0002162: 1246677

NC_008311
type: RefSeq
SIO_000068: refseq

PRJNA485481
type: BioProject
SIO_000068: bioproject

1
title: Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4
author: McFadden, N.
author: Bailey, D.
author: Carrara, G.
author: Benson, A.
author: Chaudhry, Y.
author: Shortland, A.
author: Heeney, J.
author: Yarovinsky, F.
author: Simmonds, P.
author: Macdonald, A.
author: Goodfellow, I.
journal: PLoS Pathog. 7 (12), E1002413 (2011)
pubmed: 22174679
comments: Publication Status: Online-Only

22174679
type: PubMed
SIO_000068: pubmed

2
title: Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells
author: Sosnovtsev, S.V.
author: Belliot, G.
author: Chang, K.O.
author: Prikhodko, V.G.
author: Thackray, L.B.
author: Wobus, C.E.
author: Karst, S.M.
author: Virgin, H.W.
author: Green, K.Y.
journal: J. Virol.
volume: 80
issue: 16
pages: 7816-7831
year: 2006
pubmed: 16873239

16873239
type: PubMed
SIO_000068: pubmed

3
title: Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages
author: Wobus, C.E.
author: Karst, S.M.
author: Thackray, L.B.
author: Chang, K.O.
author: Sosnovtsev, S.V.
author: Belliot, G.
author: Krug, A.
author: Mackenzie, J.M.
author: Green, K.Y.
author: Virgin, H.W.
journal: PLoS Biol. 2 (12), E432 (2004)
pubmed: 15562321

15562321
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (30-AUG-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
author: Wobus, C.E.
author: Karst, S.M.
author: Thackray, L.B.
author: Chang, K.-O.
author: Sosnovtsev, S.V.
author: Belliot, G.
author: Krug, A.
author: Mackenzie, J.M.
author: Green, K.Y.
author: Virgin, H.W. IV.
journal: Submitted (08-NOV-2005) Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7382:1
position: 7382
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-7382:1:source
so part of: sequence
organism: Norovirus GV
mol type: genomic RNA
isolate: Mu/NoV/GV/MNV1/2002/USA
isolation source: brain of interferon-alpha/beta/gamma receptor knock-out mouse
clone: CW1
sub clone: P3
country: USA
note: plaque purified three times and passaged three times

1246677
type: Taxonomy
SIO_000068: taxonomy

5'UTR
type: Five Prime UTR
subclass of: SO_0000204
RO_0002162: 1246677
so part of: sequence
location: 1..5
location: region:1-5:1
so has part: feature:1-5:1:region

position:5:1
position: 5
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-5:1:region

NoVGV_gp1
type: Gene
subclass of: SO_0000704
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
so part of: sequence
location: 6..5069
location: region:6-5069:1
so has part: feature:6-5069:1:exon
subclass of: SO_0000010

4246735
type: Gene
SIO_000068: ncbigene

position:6:1
position: 6
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5069:1
position: 5069
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6-5069:1:exon

NoVGV_gp1
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
note: ORF1; encodes helicase, protease, and polymerase
codon start: 1
product: nonstructural polyprotein
translation: MRMATPSSAPSVRNTEKRKNKKASSKASVSFGAPSPLSSESEDEINYMTPPEQEAQPGALAALHAEGPLAGLPVTRSDARVLIFNEWEERKKSDPWLRLDMSDKAIFRRYPHLRPKEDRPDAPSHAEDAMDAKEPVIGSILEQDDHKFYHYSVYIGGGLVMGVNNPSAAVCQATIDVEKLHLWWRPVWEPRHPLDSAELRKCVGMTVPYVATTVNCYQVCCWIVGIKDTWLKRAKISRDLPFYSPVQDWNVDPQEPFIPSKLRMVSDGILVALSAVIGRPIKNLLASVKPLNILNIVLSCDWTFSGIVNALILLAELFDIFWTPPDVTNWMISIFGEWQAEGPFDLALDVVPTLLGGIGMAFGLTSETIGRKLASTNSALKAAQEMGKFAIEVFKQIMAWIWPSEDPVPALLSNMEQAIIKNECQLENQLTAMLRDRNAGAEFLRSLDEEEQEVRKIAAKCGNSATTGTTNALLARISMARAAFEKARAEQTSRVRPVVIMVSGRPGIGKTCFCQNLAKRIAASLGDETSVGIIPRADVDHWDAYKGARVVLWDDFGMDNVVKDALRLQMLADTCPVTLNCDRIENKGKMFDSQVIIITTNQQTPVPLDYVNLEAVCRRIDFLVYAESPVVDDARARAPGDVNAVKAAMRPDYSHINFILAPQGGFDRQGNTPYGKGVTKIIGATALCARAVALVHERHDDFGLQNKVYDFDAGKITAFKAMAADAGIPWYKMAAIGCKAMGCTCVEEAMHLLKDYEVAPCQVIYNGATYNVSCIKGAPMVEKVKEPELPKTLVNCVRRIKEARLRCYCRMAADVITSILQAAGTAFSIYHQIEKRSRPSFYWDRGYTYRDGPGSFDIFEDDDDGWYHSEGKKGKNKKGRGRPGVFRTRGLTDEEYDEFKKRRESRGGKYSIDDYLADREREEELLERDEEEAIFGDGFGLKATRRSRKAERAKLGLVSGGDIRARKPIDWNVVGPSWADDDRQVDYGEKINFEAPVSIWSRVVQFGTGWGFWVSGHVFITAKHVAPPKGTEIFGRKPGDFTVTSSGDFLKYYFTSAVRPDIPAMVLENGCQEGVVASVLVKRASGEMLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKGNTWVVIGVHVAATRSGNTVIAATHGEPTLEALEFQGPPMLPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEKYYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGTMDAETPQERSAVFVNEDE
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 6..5069
location: region:6-5069:1
so has part: feature:6-5069:1:exon

YP_720001.1
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:6-5069:1:exon

NoVGV_gp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
product: p48
note: NS1-2; N-terminal cleavage product; N-terminal leader p48; 2A2-2B-like membrane protein; distant homolog of H-rev107-like parechovirus 2a2
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 6..1028
location: region:6-1028:1
so has part: feature:6-1028:1:exon

YP_724455.1
type: Protein
SIO_000068: ncbiprotein

position:1028:1
position: 1028
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6-1028:1:exon

NoVGV_gp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
product: NTPase
note: NS3; 2C-L; probable ortholog of the 2C protein of picornaviruses; the calicivirus NTPase was found in membranous replication complexes
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 1029..2120
location: region:1029-2120:1
so has part: feature:1029-2120:1:exon

YP_724457.1
type: Protein
SIO_000068: ncbiprotein

position:1029:1
position: 1029
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2120:1
position: 2120
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1029-2120:1:exon

NoVGV_gp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
product: p22
note: NS4;3A-like protein; 3A-L; located in the polyprotein between NTPase and VPg; second most variable region of the calicivirus polyprotein; the FCV ortholog was detected in membranous replication complexes
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 2121..2615
location: region:2121-2615:1
so has part: feature:2121-2615:1:exon

YP_724458.1
type: Protein
SIO_000068: ncbiprotein

position:2121:1
position: 2121
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2615:1
position: 2615
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2121-2615:1:exon

NoVGV_gp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
product: VPg
note: NS5; For Southampton calicivirus, both N-terminal and C-terminal cleavage sites have been confirmed by direct sequencing. In caliciviruses, VPg can also exist in the form of precursor with the upstream protein which is thought to function as a membrane anchor
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 2616..2987
location: region:2616-2987:1
so has part: feature:2616-2987:1:exon

YP_724459.1
type: Protein
SIO_000068: ncbiprotein

position:2616:1
position: 2616
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2987:1
position: 2987
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2616-2987:1:exon

NoVGV_gp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
product: Pro
note: NS6;3C-PRO; Chymotrypsin-like cysteine proteinase; for Southampton calicivirus, both N-terminal and C-terminal cleavage sites have been confirmed by direct sequencing; can exist in the form of a stable NS6-NS7 precursor
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 2988..3536
location: region:2988-3536:1
so has part: feature:2988-3536:1:exon

YP_724460.1
type: Protein
SIO_000068: ncbiprotein

position:2988:1
position: 2988
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:3536:1
position: 3536
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2988-3536:1:exon

NoVGV_gp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 1246677
gene: ORF1
locus tag: NoVGV_gp1
old locus tag: MNV1_gp1
product: RdRp
note: NS7; Pol; RNA-dependent RNA polymerase; can exist as a stable NS6-NS7 precursor
SIO_010081: NoVGV_gp1
subclass of: SO_0000673
so part of: NoVGV_gp1
location: 3537..5066
location: region:3537-5066:1
so has part: feature:3537-5066:1:exon

YP_724456.1
type: Protein
SIO_000068: ncbiprotein

position:3537:1
position: 3537
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:5066:1
position: 5066
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3537-5066:1:exon

NoVGV_gp2
type: Gene
subclass of: SO_0000704
RO_0002162: 1246677
gene: ORF2
locus tag: NoVGV_gp2
old locus tag: MNV1_gp2
so part of: sequence
location: 5056..6681
location: region:5056-6681:1
so has part: feature:5056-6681:1:exon
subclass of: SO_0000010

4246736
type: Gene
SIO_000068: ncbigene

position:5056:1
position: 5056
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6681:1
position: 6681
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5056-6681:1:exon

NoVGV_gp2
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 1246677
gene: ORF2
locus tag: NoVGV_gp2
old locus tag: MNV1_gp2
note: formerly known as 'ORF2 protein'; capsid protein VP1
codon start: 1
product: VP1
translation: MRMSDGAAPKANGSEASGQDLVPAAVEQAVPIQPVAGAALAAPAAGQINQIDPWIFQNFVQCPLGEFSISPRNTPGEILFDLALGPGLNPYLAHLSAMYTGWVGNMEVQLVLAGNAFTAGKVVVALVPPYFPKGSLTTAQITCFPHVMCDVRTLEPIQLPLLDVRRVLWHATQDQEESMRLVCMLYTPLRTNSPGDESFVVSGRLLSKPAADFNFVYLTPPIERTIYRMVDLPVIQPRLCTHARWPAPVYGLLVDPSLPSNPQWQNGRVHVDGTLLGTTPISGSWVSCFAAEAAYEFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQLEIEVQTETTKTGDKLKVTTFEMILGPTTNADQAPYQGRVFASVTAAASLDLVDGRVRAVPRSIYGFQDTIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQIDTADAAAEAIDCALPQEFVSWFASNAFTVQSEALLLRYRNTLTGQLLFECKLYNEGYIALSYSGSGPLTFPTDGIFEVVSWVPRLYQLASVGSLATGRMLKQ
SIO_010081: NoVGV_gp2
subclass of: SO_0000673
so part of: NoVGV_gp2
location: 5056..6681
location: region:5056-6681:1
so has part: feature:5056-6681:1:exon

YP_720002.1
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:5056-6681:1:exon

NoVGV_gp4
type: Gene
subclass of: SO_0000704
RO_0002162: 1246677
gene: ORF4
locus tag: NoVGV_gp4
old locus tag: MNV1_gp4
so part of: sequence
location: 5069..5710
location: region:5069-5710:1
so has part: feature:5069-5710:1:exon
subclass of: SO_0000010

12979196
type: Gene
SIO_000068: ncbigene

position:5710:1
position: 5710
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5069-5710:1:exon

NoVGV_gp4
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 1246677
gene: ORF4
locus tag: NoVGV_gp4
old locus tag: MNV1_gp4
note: formerly called ORF4; Virulence factor 1 has been added by NCBI Staff with the kind help of Dr. David Karlin(Department of Zoology, University of Oxford, UK).
codon start: 1
product: VF1
translation: MAQRQKPMALRPAARILFLPPLNRPSPFNPWLARLLPPPPPGKLTKLTPGSSKILSSAPLVSFPSRLETPQVKYCLIWPSGQGLTPTLPTSQPCTPAGLGTWRFSWSSPAMPLLLARWLLPLYHPIFPRGHSLLPRSHASHMSCVMCAPWSPFNSLFLMCVESFGMLPRIKRNLCAWFACCTRHSAQTARVMSLLWSLAAFFLSRRLISILST
SIO_010081: NoVGV_gp4
subclass of: SO_0000673
so part of: NoVGV_gp4
location: 5069..5710
location: region:5069-5710:1
so has part: feature:5069-5710:1:exon

YP_006390081.1
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:5069-5710:1:exon

NoVGV_gp3
type: Gene
subclass of: SO_0000704
RO_0002162: 1246677
gene: ORF3
locus tag: NoVGV_gp3
old locus tag: MNV1_gp3
so part of: sequence
location: 6681..7307
location: region:6681-7307:1
so has part: feature:6681-7307:1:exon
subclass of: SO_0000010

4246737
type: Gene
SIO_000068: ncbigene

position:7307:1
position: 7307
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6681-7307:1:exon

NoVGV_gp3
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 1246677
gene: ORF3
locus tag: NoVGV_gp3
old locus tag: MNV1_gp3
note: minor capsid protein VP2; formerly known as 'ORF3 protein'; small basic protein
codon start: 1
product: VP2
translation: MAGALFGAIGGGLMGIIGNSISNVQNLQANKQLAAQQFGYNSSLLATQIQAQKDLTLMGQQFNQQLQTNSFKHDLEMLGAQVQAQAQAQENAINIKTAQLQAAGFSKTDAARLALGQQPTRAVDWSGTRYYTANQPVTGFSGGFTPTYTPGRQVTSRPVDTSPLPISGGRLPSLRGGSWSPRDHTPATQGTYTNGRFVSLPKIGSSRA
SIO_010081: NoVGV_gp3
subclass of: SO_0000673
so part of: NoVGV_gp3
location: 6681..7307
location: region:6681-7307:1
so has part: feature:6681-7307:1:exon

YP_720003.1
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:6681-7307:1:exon

3'UTR
type: Three Prime UTR
subclass of: SO_0000205
RO_0002162: 1246677
so part of: sequence
location: 7308..7382
location: region:7308-7382:1
so has part: feature:7308-7382:1:region

position:7308:1
position: 7308
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7308-7382:1:region