Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4
Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells
Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages
Submitted (30-AUG-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (08-NOV-2005) Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, USA
REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from DQ285629.\nCOMPLETENESS: full length.
brain of interferon-alpha/beta/gamma receptor knock-out mouse
plaque purified three times and passaged three times
ORF1; encodes helicase, protease, and polymerase
NS1-2; N-terminal cleavage product; N-terminal leader p48; 2A2-2B-like membrane protein; distant homolog of H-rev107-like parechovirus 2a2
NS3; 2C-L; probable ortholog of the 2C protein of picornaviruses; the calicivirus NTPase was found in membranous replication complexes
NS4;3A-like protein; 3A-L; located in the polyprotein between NTPase and VPg; second most variable region of the calicivirus polyprotein; the FCV ortholog was detected in membranous replication complexes
NS5; For Southampton calicivirus, both N-terminal and C-terminal cleavage sites have been confirmed by direct sequencing. In caliciviruses, VPg can also exist in the form of precursor with the upstream protein which is thought to function as a membrane anchor
NS6;3C-PRO; Chymotrypsin-like cysteine proteinase; for Southampton calicivirus, both N-terminal and C-terminal cleavage sites have been confirmed by direct sequencing; can exist in the form of a stable NS6-NS7 precursor
NS7; Pol; RNA-dependent RNA polymerase; can exist as a stable NS6-NS7 precursor
formerly known as 'ORF2 protein'; capsid protein VP1
formerly called ORF4; Virulence factor 1 has been added by NCBI Staff with the kind help of Dr. David Karlin(Department of Zoology, University of Oxford, UK).
minor capsid protein VP2; formerly known as 'ORF3 protein'; small basic protein