West Nile virus lineage 2, complete genome.
type: Entry
definition: West Nile virus lineage 2, complete genome.
sequence version: NC_001563.2
sequence date: 2019-08-01
sequence: sequence
division: VRL
label: NC_001563.2
type: RefSeq
SIO_000068: refseq
dblink: PRJNA485481
keyword: RefSeq
source: West Nile virus (WNV)
organism: West Nile virus
taxonomy: Viruses; Riboviria; Flaviviridae; Flavivirus.
reference: 1
references: 19906906
reference: 2
references: 11277701
reference: 3
reference: 4
reference: 5
comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from M12294.\nOn Dec 3, 2000 this sequence version replaced NC_001563.1.\nThe West Nile viral genome consists of a 42S viral RNA. The\namino-terminal ends of the structural proteins were experimentally\ndetermined and annotated in the authors' submission AAA48498 - see\ncorresponding comment there. The (putative) mature peptides that\nwere missing from or conflicting with the authors' annotation have\nbeen added to this RefSeq record by the NCBI staff with the kind\nhelp of Dr. Vladimir Yamshchikov (Southern Research Institute,\nBirmingham, AL USA).\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000353
sequence length: 10962
topology: linear
so has quality: SO_0000987
location: 1..10962
location: region:1-10962:1
RO_0002162: 11082

NC_001563
type: RefSeq
SIO_000068: refseq

PRJNA485481
type: BioProject
SIO_000068: bioproject

1
title: NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness
author: Melian, E.B.
author: Hinzman, E.
author: Nagasaki, T.
author: Firth, A.E.
author: Wills, N.M.
author: Nouwens, A.S.
author: Blitvich, B.J.
author: Leung, J.
author: Funk, A.
author: Atkins, J.F.
author: Hall, R.
author: Khromykh, A.A.
journal: J. Virol.
volume: 84
issue: 3
pages: 1641-1647
year: 2010
pubmed: 19906906

19906906
type: PubMed
SIO_000068: pubmed

2
title: An infectious clone of the West Nile flavivirus
author: Yamshchikov, V.F.
author: Wengler, G.
author: Perelygin, A.A.
author: Brinton, M.A.
author: Compans, R.W.
journal: Virology
volume: 281
issue: 2
pages: 294-304
year: 2001
pubmed: 11277701

11277701
type: PubMed
SIO_000068: pubmed

3
title: Direct Submission
journal: Submitted (09-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

4
title: Direct Submission
author: Yamshchikov, V.F.
journal: Submitted (01-DEC-2000) University of Virginia Health Sciences Centre, Department of Internal Medicine/GI, Charlottesville, VA 22906

5
title: Direct Submission
author: Castle, E.
journal: Submitted (03-AUG-1993) Justus-Liebig-Universitat Giessen, Institut fur Virologie, 35392, Giessen, Germany

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:10962:1
position: 10962
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-10962:1:source
so part of: sequence
organism: West Nile virus
mol type: genomic RNA
strain: 956
clone: 33/G8; 34/F6
note: lineage 2

11082
type: Taxonomy
SIO_000068: taxonomy

5'UTR
type: Five Prime UTR
subclass of: SO_0000204
RO_0002162: 11082
so part of: sequence
location: 1..96
location: region:1-96:1
so has part: feature:1-96:1:region

position:96:1
position: 96
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-96:1:region

WNVgp1
type: Gene
subclass of: SO_0000704
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
so part of: sequence
location: 97..10389
location: region:97-10389:1
so has part: feature:97-10389:1:exon
subclass of: SO_0000010

912267
type: Gene
SIO_000068: ncbigene

position:97:1
position: 97
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:10389:1
position: 10389
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97-10389:1:exon

WNVgp1
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 97..10389
location: region:97-10389:1
so has part: feature:97-10389:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:97-10389:1:exon

WNVgp1
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
codon start: 1
product: polyprotein
translation: MSKKPGGPGKNRAVNMLKRGMPRGLSLIGLKRAMLSLIDGKGPIRFVLALLAFFRFTAIAPTRAVLDRWRGVNKQTAMKHLLSFKKELGTLTSAINRRSTKQKKRGGTAGFTILLGLIACAGAVTLSNFQGKVMMTVNATDVTDVITIPTAAGKNLCIVRAMDVGYLCEDTITYECPVLAAGNDPEDIDCWCTKSSVYVRYGRCTKTRHSRRSRRSLTVQTHGESTLANKKGAWLDSTKATRYLVKTESWILRNPGYALVAAVIGWMLGSNTMQRVVFAILLLLVAPAYSFNCLGMSNRDFLEGVSGATWVDLVLEGDSCVTIMSKDKPTIDVKMMNMEAANLADVRSYCYLASVSDLSTRAACPTMGEAHNEKRADPAFVCKQGVVDRGWGNGCGLFGKGSIDTCAKFACTTKATGWIIQKENIKYEVAIFVHGPTTVESHGKIGATQAGRFSITPSAPSYTLKLGEYGEVTVDCEPRSGIDTSAYYVMSVGEKSFLVHREWFMDLNLPWSSAGSTTWRNRETLMEFEEPHATKQSVVALGSQEGALHQALAGAIPVEFSSNTVKLTSGHLKCRVKMEKLQLKGTTYGVCSKAFKFARTPADTGHGTVVLELQYTGTDGPCKVPISSVASLNDLTPVGRLVTVNPFVSVATANSKVLIELEPPFGDSYIVVGRGEQQINHHWHKSGSSIGKAFTTTLRGAQRLAALGDTAWDFGSVGGVFTSVGKAIHQVFGGAFRSLFGGMSWITQGLLGALLLWMGINARDRSIAMTFLAVGGVLLFLSVNVHADTGCAIDIGRQELRCGSGVFIHNDVEAWMDRYKFYPETPQGLAKIIQKAHAEGVCGLRSVSRLEHQMWEAIKDELNTLLKENGVDLSVVVEKQNGMYKAAPKRLAATTEKLEMGWKAWGKSIIFAPELANNTFVIDGPETEECPTANRAWNSMEVEDFGFGLTSTRMFLRIRETNTTECDSKIIGTAVKNNMAVHSDLSYWIESGLNDTWKLERAVLGEVKSCTWPETHTLWGDGVLESDLIIPITLAGPRSNHNRRPGYKTQNQGPWDEGRVEIDFDYCPGTTVTISDSCEHRGPAARTTTESGKLITDWCCRSCTLPPLRFQTENGCWYGMEIRPTRHDEKTLVQSRVNAYNADMIDPFQLGLMVVFLATQEVLRKRWTAKISIPAIMLALLVLVFGGITYTDVLRYVILVGAAFAEANSGGDVVHLALMATFKIQPVFLVASFLKARWTNQESILLMLAAAFFQMAYYDAKNVLSWEVPDVLNSLSVAWMILRAISFTNTSNVVVPLLALLTPGLKCLNLDVYRILLLMVGVGSLIKEKRSSAAKKKGACLICLALASTGVFNPMILAAGLMACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDIDSMAIPMTIAGLMFAAFVISGKSTDMWIERTADITWESDAEITGSSERVDVRLDDDGNFQLMNDPGAPWKIWMLRMACLAISAYTPWAILPSVIGFWITLQYTKRGGVLWDTPSPKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHTTKGAALMSGEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGHDEVQMIVVEPGKNVKNVQTKPGVFKTPEGEIGAVTLDYPTGTSGSPIVDKNGDVIGLYGNGVIMPNGSYISAIVQGERMEEPAPAGFEPEMLRKKQITVLDLHPGAGKTRKILPQIIKEAINKRLRTAVLAPTRVVAAEMSEALRGLPIRYQTSAVHREHSGNEIVDVMCHATLTHRLMSPHRVPNYNLFIMDEAHFTDPASIAARGYIATKVELGEAAAIFMTATPPGTSDPFPESNAPISDMQTEIPDRAWNTGYEWITEYVGKTVWFVPSVKMGNEIALCLQRAGKKVIQLNRKSYETEYPKCKNDDWDFVITTDISEMGANFKASRVIDSRKSVKPTIIEEGDGRVILGEPSAITAASAAQRRGRIGRNPSQVGDEYCYGGHTNEDDSNFAHWTEARIMLDNI…
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 97..10389
location: region:97-10389:1
so has part: feature:97-10389:1:exon

NP_041724.2
type: Protein
SIO_000068: ncbiprotein

urn:…
SIO_000300: 1
SIO_000628: feature:97-10389:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: anchored capsid protein ancC
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 97..465
location: region:97-465:1
so has part: feature:97-465:1:exon

NP_776011.1
type: Protein
SIO_000068: ncbiprotein

position:465:1
position: 465
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97-465:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: capsid protein C
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 97..411
location: region:97-411:1
so has part: feature:97-411:1:exon

NP_776010.1
type: Protein
SIO_000068: ncbiprotein

position:411:1
position: 411
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97-411:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: membrane glycoprotein precursor prM
note: matrix protein precursor; membrane glycoprotein precursor prM
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 466..966
location: region:466-966:1
so has part: feature:466-966:1:exon

NP_776012.1
type: Protein
SIO_000068: ncbiprotein

position:466:1
position: 466
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:966:1
position: 966
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466-966:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: protein pr
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 466..741
location: region:466-741:1
so has part: feature:466-741:1:exon

YP_009164951.1
type: Protein
SIO_000068: ncbiprotein

position:741:1
position: 741
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466-741:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: membrane glycoprotein M
note: matrix protein
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 742..966
location: region:742-966:1
so has part: feature:742-966:1:exon

NP_776013.1
type: Protein
SIO_000068: ncbiprotein

position:742:1
position: 742
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:742-966:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: envelope protein E
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 967..2457
location: region:967-2457:1
so has part: feature:967-2457:1:exon

NP_776014.1
type: Protein
SIO_000068: ncbiprotein

position:967:1
position: 967
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:2457:1
position: 2457
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:967-2457:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS1
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 2458..3513
location: region:2458-3513:1
so has part: feature:2458-3513:1:exon

NP_776015.1
type: Protein
SIO_000068: ncbiprotein

position:2458:1
position: 2458
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:3513:1
position: 3513
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2458-3513:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS2A
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 3514..4206
location: region:3514-4206:1
so has part: feature:3514-4206:1:exon

NP_776016.1
type: Protein
SIO_000068: ncbiprotein

position:3514:1
position: 3514
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:4206:1
position: 4206
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3514-4206:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS2B
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 4207..4599
location: region:4207-4599:1
so has part: feature:4207-4599:1:exon

NP_776017.1
type: Protein
SIO_000068: ncbiprotein

position:4207:1
position: 4207
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:4599:1
position: 4599
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4207-4599:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS3
note: protease; nucleotide triphosphatase; RNA triphosphatase; RNA helicase
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 4600..6456
location: region:4600-6456:1
so has part: feature:4600-6456:1:exon

NP_776018.1
type: Protein
SIO_000068: ncbiprotein

position:4600:1
position: 4600
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6456:1
position: 6456
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4600-6456:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS4A
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 6457..6834
location: region:6457-6834:1
so has part: feature:6457-6834:1:exon

NP_776019.1
type: Protein
SIO_000068: ncbiprotein

position:6457:1
position: 6457
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6834:1
position: 6834
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6457-6834:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: protein 2K
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 6835..6903
location: region:6835-6903:1
so has part: feature:6835-6903:1:exon

NP_776020.1
type: Protein
SIO_000068: ncbiprotein

position:6835:1
position: 6835
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6903:1
position: 6903
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6835-6903:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS4B
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 6904..7671
location: region:6904-7671:1
so has part: feature:6904-7671:1:exon

NP_776021.1
type: Protein
SIO_000068: ncbiprotein

position:6904:1
position: 6904
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7671:1
position: 7671
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6904-7671:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: RNA-dependent RNA polymerase NS5
note: nonstructural protein NS5; RNA-dependent RNA polymerase; methyltransferase component of capping enzyme
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: 7672..10386
location: region:7672-10386:1
so has part: feature:7672-10386:1:exon

NP_776022.1
type: Protein
SIO_000068: ncbiprotein

position:7672:1
position: 7672
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:10386:1
position: 10386
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7672-10386:1:exon

WNVgp1
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
note: NS1' protein; transframe fusion protein expressed via programmed ribosomal frameshifting; when frameshifting occurs, cleavage between NS1 and NS2A fails to occur
codon start: 1
product: truncated polyprotein NS1 prime
translation: MSKKPGGPGKNRAVNMLKRGMPRGLSLIGLKRAMLSLIDGKGPIRFVLALLAFFRFTAIAPTRAVLDRWRGVNKQTAMKHLLSFKKELGTLTSAINRRSTKQKKRGGTAGFTILLGLIACAGAVTLSNFQGKVMMTVNATDVTDVITIPTAAGKNLCIVRAMDVGYLCEDTITYECPVLAAGNDPEDIDCWCTKSSVYVRYGRCTKTRHSRRSRRSLTVQTHGESTLANKKGAWLDSTKATRYLVKTESWILRNPGYALVAAVIGWMLGSNTMQRVVFAILLLLVAPAYSFNCLGMSNRDFLEGVSGATWVDLVLEGDSCVTIMSKDKPTIDVKMMNMEAANLADVRSYCYLASVSDLSTRAACPTMGEAHNEKRADPAFVCKQGVVDRGWGNGCGLFGKGSIDTCAKFACTTKATGWIIQKENIKYEVAIFVHGPTTVESHGKIGATQAGRFSITPSAPSYTLKLGEYGEVTVDCEPRSGIDTSAYYVMSVGEKSFLVHREWFMDLNLPWSSAGSTTWRNRETLMEFEEPHATKQSVVALGSQEGALHQALAGAIPVEFSSNTVKLTSGHLKCRVKMEKLQLKGTTYGVCSKAFKFARTPADTGHGTVVLELQYTGTDGPCKVPISSVASLNDLTPVGRLVTVNPFVSVATANSKVLIELEPPFGDSYIVVGRGEQQINHHWHKSGSSIGKAFTTTLRGAQRLAALGDTAWDFGSVGGVFTSVGKAIHQVFGGAFRSLFGGMSWITQGLLGALLLWMGINARDRSIAMTFLAVGGVLLFLSVNVHADTGCAIDIGRQELRCGSGVFIHNDVEAWMDRYKFYPETPQGLAKIIQKAHAEGVCGLRSVSRLEHQMWEAIKDELNTLLKENGVDLSVVVEKQNGMYKAAPKRLAATTEKLEMGWKAWGKSIIFAPELANNTFVIDGPETEECPTANRAWNSMEVEDFGFGLTSTRMFLRIRETNTTECDSKIIGTAVKNNMAVHSDLSYWIESGLNDTWKLERAVLGEVKSCTWPETHTLWGDGVLESDLIIPITLAGPRSNHNRRPGYKTQNQGPWDEGRVEIDFDYCPGTTVTISDSCEHRGPAARTTTESGKLITDWCCRSCTLPPLRFQTENGCWYGMEIRPTRHDEKTLVQSRVNAYNADMIDPFSVGPYGRVLGHPGGPSQEVDGQDQHSSYHACTPSPSVWGYYVH
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: join(97..3540,3540..3671)
location: region:97-3671:1
so has part: feature:97-3540:1:exon
so has part: feature:3540-3671:1:exon

YP_009164950.1
type: Protein
SIO_000068: ncbiprotein

position:3671:1
position: 3671
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97-3540:1:exon

position:3540:1
position: 3540
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:3540-3671:1:exon

WNVgp1
type: Mature Peptide
subclass of: SO_0000419
RO_0002162: 11082
gene: POLY
locus tag: WNVgp1
product: nonstructural protein NS1 prime
note: NS1'; transframe fusion protein expressed via programmed ribosomal frameshifting; when frameshifting occurs, cleavage between NS1 and NS2A fails to occur
SIO_010081: WNVgp1
subclass of: SO_0000673
so part of: WNVgp1
location: join(2458..3540,3540..3668)
location: region:2458-3668:1
so has part: feature:2458-3540:1:exon
so has part: feature:3540-3668:1:exon

YP_009164952.1
type: Protein
SIO_000068: ncbiprotein

position:3668:1
position: 3668
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2458-3540:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:3540-3668:1:exon

3'UTR
type: Three Prime UTR
subclass of: SO_0000205
RO_0002162: 11082
so part of: sequence
location: 10390..10962
location: region:10390-10962:1
so has part: feature:10390-10962:1:region

position:10390:1
position: 10390
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:10390-10962:1:region