Viruses; Riboviria; Flaviviridae; Flavivirus.
New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences
NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness
Complete nucleotide sequence of the Japanese encephalitis virus genome RNA
Submitted (01-AUG-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
REVIEWED REFSEQ: This record has been curated by NCBI staff. The\nreference sequence was derived from M18370.\nTruncated version of JEV polyprotein and NS1' protein have been\nadded and annotated with the kind help of Dr. David\nKarlin(Department of Zoology, University of Oxford, UK) and Dr.\nAndrew Firth (Department of Pathology, University of Cambridge,\nUK).\nDraft entry and computer-readable sequence for [1] kindly submitted\nby H.Sumiyoshi, 31-AUG-1989.\nCOMPLETENESS: not full length.
JEV polyprotein; The (putative) mature peptides that were missing from the authors' annotation have been added by the NCBI staff with the kind help of Dr. Vladimir Yamshchikov (University of Kansas, Lawrence, KS USA)
prM/E cleavage site evidence: N-terminal amino acid sequencing, PMID: 3686827
pr/M cleavage site evidence: N-terminal amino acid sequencing, PMID: 3686827
E/NS1 cleavage site predicted by SignalP 4.1
RdRp; nonstructural protein NS5; methyltransferase component of capping enzyme
Truncated version of JEV polyprotein that will be produced when frameshifting occurs at nt 3560; predicted to be produced from ribosomal frameshifting
Transframe fusion protein, the mature peptide consists of the N-terminal portion of NS1 and the alternative reading frame translation that occurs after a programmed ribosomal frameshift; When frameshifting occurs, cleavage between NS1 and NS2A fails to occur; May be similar to NS1-NS2AN-FIFO protein.