Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus.
Development and assessment of human adenovirus type 11 as a gene transfer vector
The complete nucleotide sequence, genome organization, and origin of human adenovirus type 11
Submitted (04-SEP-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (16-OCT-2002) Division of Medical Genetics, University of Washington, Health Sciences Building, 1705 NE Pacific Street, Seattle, WA 98195, USA
REVIEWED REFSEQ: This record has been curated by Dr Andrew Davison\n(MRC Virology Unit, Glasgow, UK) and Dr Balazs Harrach (Veterinary\nMedical Research Institute, Budapest, Hungary). The reference\nsequence was derived from AY163756.\nCURATION:\n Proteins: A standard nomenclature has been applied so that\northologs have the same name. Functional information may have been\npropagated from other adenovirus species. Protein-coding regions:\nThe initiation codon for each CDS is assigned with as much\nconfidence as possible. CDSs presumably inherited from the last\ncommon ancestor of all adenoviruses are indicated as genus-common,\nand all other CDSs as genus-specific. CDSs that have paralogues in\none or more genomes are listed as members of named families. The\nevolutionary history of E3 and E4 is complex, frequently involving\ngeneration or loss of paralogues in whole or in part, accompanied\nby rapid sequence divergence. In E3, this is evident in a set of\ntandemly arranged CDSs encoding transmembrane proteins. All of\nthese are listed as members of the MP family, regardless of whether\nsequence conservation is detectable. Transcripts: In\nmastadenoviruses, transcription arises from the early genes (E1A,\nE1B, E2A, E2B, E3 and E4), the intermediate genes (IX and IVa2) and\nthe late genes (L, U and E2A-L). Certain transcriptional features\nare supported by experimental data for some of these genes in a few\nadenoviruses (particularly human adenovirus C). All transcriptional\nfeatures not marked as experimentally supported are predictions\nmade on the basis of conservation and relevance to CDS expression.\nThe degree of confidence in each prediction depends on the feature\nunder consideration. In primate adenoviruses, predictions for E3,\nE4 and the 5'-regions of E2A and E2B are generally the least\ncertain. In non-primate mastadenoviruses, this trend is accentuated\nto the degree that predictions for introns in E3 and E4 are not\nprovided, and those for the 5'-regions of E2A, E2B and IVa2 and for\nthe intron separating the protein-coding exons of 33K are\nparticularly tentative. In human adenovirus C, rightward-oriented\ntranscripts from the late genes (L1-L5) are polyadenylated close\ndownstream from polyadenylation signals at five locations (the\n3'-ends of the pIIIa, pX, protease, control protein E3 12.5K and\nfiber CDSs), and those from the E3 genes (E3A and E3B) at two\nlocations (the 3'-ends of the membrane protein E3 CR1-beta and\ncontrol protein E3 14.7K CDSs). Only the polyadenylation signals\nfor L3, E3B and L5 are conserved among all mastadenoviruses,\nwhereas those for L1 and L2 are conserved in most mastadenoviruses\nand those for L4 and E3A in a few. In addition, potential\nadditional polyadenylation signals exist at the 3'-ends of the\npenton base, pVII, V, pVI and fiber-2 CDSs in some\nmastadenoviruses, particularly those with non-primate hosts; the\ncorresponding genes are listed as L1A, L1B, L1C, L2A and L5A,\nrespectively. The gene corresponding to E3B is termed E3 in genomes\nlacking the E3A polyadenylation signal. In some instances where a\nTATA signal is not convincingly evident (particularly for E2A/E2B),\na tentative assignment is made and marked as nominal.\nCOMPLETENESS: full length.
genus-specific; alternative splicing utilizing nonconserved sites may produce additional proteins
alternative splicing utilizing nonconserved sites may produce additional proteins; genus-specific
between L2 and i leaders; precedes protein 13.6K CDS
i-leader protein; similar CDSs are present in some other human mastadenoviruses, but their conservation may merely be a secondary effect of conservation of DNA polymerase encoded on the opposing strand; alternatively spliced
covalently attached to genome 5'-termini; genus-common
precedes capsid protein precursor pVIII CDS
precedes protein 33K and encapsidation protein 22K CDSs
precedes hexon assembly protein 100K CDS
precedes capsid protein precursor pVI CDS
precedes core protein precursor pVII CDS
precedes capsid protein precursor pIIIa CDS
precedes DNA polymerase and terminal protein precursor pTP CDSs
putative type 2 membrane protein; product Mu; genus-common
cleaved peptide stimulates protease; genus-common
E2A, E2A-L; precedes single-stranded DNA-binding protein CDS
precedes membrane protein E3 RID-beta CDS
precedes membrane protein E3 RID-alpha CDS
precedes membrane glycoprotein E3 CR1-gamma CDS
precedes membrane glycoprotein E3 CR1-beta CDS
precedes membrane glycoprotein E3 gp19K CDS
precedes membrane glycoprotein E3 CR1-alpha CDS
0 CR1 domains; genus-specific; MP family
binds to MHC-I and inhibits transport; genus-specific; MP family
exon encoding C terminus unidentified; genus-common
capsid protein IV; genus-common; fiber family