Providencia huaxiensis strain WCHPr000369 plasmid pIMP69_000369, complete sequence.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Morganellaceae; Providencia.

A Pandrug-Resistant Providencia Carrying Two blaIMP Carbapenemase-Encoding Genes Including blaIMP-69, a New blaIMP Variant, on a Newly Identified Worldwide-Distributed IncC Plasmid

Providencia huaxiensis sp. nov., recovered from a human rectal swab

Submitted (17-JUL-2018) Center of Infectious Diseases, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan 610041, China

Submitted (17-AUG-2017) Center of Infectious Diseases, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan 610041, China

REFSEQ INFORMATION: The reference sequence is identical to\nCP031122.1.\nThe annotation was added by the NCBI Prokaryotic Genome Annotation\nPipeline (PGAP). Information about PGAP can be found here:\nhttps://www.ncbi.nlm.nih.gov/genome/annotation_prok/\n\n##Genome-Assembly-Data-START##\nAssembly Method :: Unicycler v. 0.4.6\nGenome Representation :: Full\nExpected Final Version :: Yes\nGenome Coverage :: 200.0x\nSequencing Technology :: Illumina HiSeq; MinION\n##Genome-Assembly-Data-END##\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: NCBI RefSeq\nAnnotation Date :: 07/04/2022 01:49:38\nAnnotation Pipeline :: NCBI Prokaryotic Genome\n Annotation Pipeline (PGAP)\nAnnotation Method :: Best-placed reference protein\n set; GeneMarkS-2+\nAnnotation Software revision :: 6.1\nFeatures Annotated :: Gene; CDS; rRNA; tRNA; ncRNA;\n repeat_region\nGenes (total) :: 4,531\nCDSs (total) :: 4,428\nGenes (coding) :: 4,340\nCDSs (with protein) :: 4,340\nGenes (RNA) :: 103\nrRNAs :: 8, 7, 7 (5S, 16S, 23S)\ncomplete rRNAs :: 8, 7, 7 (5S, 16S, 23S)\ntRNAs :: 77\nncRNAs :: 4\nPseudo Genes (total) :: 88\nCDSs (without protein) :: 88\nPseudo Genes (ambiguous residues) :: 0 of 88\nPseudo Genes (frameshifted) :: 23 of 88\nPseudo Genes (incomplete) :: 62 of 88\nPseudo Genes (internal stop) :: 10 of 88\nPseudo Genes (multiple problems) :: 5 of 88\nCRISPR Arrays :: 1\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

COORDINATES: similar to AA sequence:RefSeq:YP_005221099.1
Derived by automated computational analysis using gene prediction method: Protein Homology.

COORDINATES: similar to AA sequence:RefSeq:YP_005221100.1
GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]
GO:0006270 - DNA replication initiation [Evidence IEA]
RepB family plasmid replication initiator protein

COORDINATES: ab initio prediction:GeneMarkS-2+
Derived by automated computational analysis using gene prediction method: GeneMarkS-2+.

COORDINATES: similar to AA sequence:RefSeq:YP_005220950.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220951.1
GO:0003824 - catalytic activity [Evidence IEA]
phosphoadenosine phosphosulfate reductase family protein

COORDINATES: similar to AA sequence:RefSeq:YP_005220953.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220954.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220955.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220956.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220957.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220958.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220959.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220960.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220961.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220962.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220963.1
Fe3+-siderophore ABC transporter permease

COORDINATES: similar to AA sequence:RefSeq:YP_005220964.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220965.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220966.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220968.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220969.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220970.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220971.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220972.1
type II toxin-antitoxin system RelE/ParE family toxin

COORDINATES: similar to AA sequence:RefSeq:YP_005220973.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220975.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220976.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220977.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220978.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220979.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220980.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220982.1

COORDINATES: similar to AA sequence:RefSeq:YP_005220983.1
incomplete; partial in the middle of a contig; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.

COORDINATES: similar to AA sequence:RefSeq:WP_076611787.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221001.1

COORDINATES: similar to AA sequence:RefSeq:WP_032489893.1
broad-spectrum class A beta-lactamase TEM-1

COORDINATES: similar to AA sequence:RefSeq:WP_012372818.1
16S rRNA (guanine(1405)-N(7))-methyltransferase RmtB1

COORDINATES: protein motif:HMM:NF013188.2
GO:0016021 - integral component of membrane [Evidence IEA]
GO:0015299 - solute:proton antiporter activity [Evidence IEA]
GO:0006812 - cation transport [Evidence IEA]; GO:0055085 - transmembrane transport [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_005411226.1
60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.

COORDINATES: similar to AA sequence:RefSeq:WP_019726358.1

COORDINATES: protein motif:HMM:NF015431.2

COORDINATES: similar to AA sequence:RefSeq:YP_005221011.1
tetracycline efflux MFS transporter Tet(G)

COORDINATES: similar to AA sequence:RefSeq:YP_005221012.1
tetracycline resistance transcriptional repressor TetR(G)

COORDINATES: similar to AA sequence:RefSeq:WP_000259026.1
incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.

COORDINATES: similar to AA sequence:RefSeq:WP_000214125.1
chloramphenicol/florfenicol efflux MFS transporter FloR2

GO:0004156 - dihydropteroate synthase activity [Evidence IEA]
GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_000679427.1
quaternary ammonium compound efflux SMR transporter QacE delta 1

COORDINATES: similar to AA sequence:RefSeq:WP_001749984.1
frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.
AadA family aminoglycoside 3''-O-nucleotidyltransferase

COORDINATES: protein motif:HMM:NF017990.2

COORDINATES: similar to AA sequence:RefSeq:WP_004187529.1
trimethoprim-resistant dihydrofolate reductase DfrA12

COORDINATES: similar to AA sequence:RefSeq:YP_005221021.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221000.1
GO:0004803 - transposase activity [Evidence IEA]
IS6-like element IS26 family transposase

COORDINATES: similar to AA sequence:RefSeq:YP_005221085.1

COORDINATES: similar to AA sequence:RefSeq:WP_001138014.1
internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology.
Tn3-like element TnAs1 family transposase

COORDINATES: similar to AA sequence:RefSeq:YP_005220837.1

COORDINATES: similar to AA sequence:RefSeq:WP_031943232.1
subclass B1 metallo-beta-lactamase IMP-69

COORDINATES: similar to AA sequence:RefSeq:WP_003159191.1
AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase

COORDINATES: similar to AA sequence:RefSeq:WP_003155741.1

COORDINATES: similar to AA sequence:RefSeq:WP_011517528.1

COORDINATES: similar to AA sequence:RefSeq:WP_003155746.1

COORDINATES: similar to AA sequence:RefSeq:WP_013124600.1
GO:0015074 - DNA integration [Evidence IEA]
DDE-type integrase/transposase/recombinase

COORDINATES: similar to AA sequence:RefSeq:YP_005229646.1

COORDINATES: similar to AA sequence:RefSeq:WP_001513488.1

COORDINATES: similar to AA sequence:RefSeq:WP_015965681.1

COORDINATES: similar to AA sequence:RefSeq:WP_076611102.1

COORDINATES: similar to AA sequence:RefSeq:WP_032492044.1
extended-spectrum class A beta-lactamase CTX-M-14

COORDINATES: similar to AA sequence:RefSeq:WP_031587700.1
IS1380-like element ISEcp1 family transposase

COORDINATES: protein motif:HMM:NF012245.2
HAMP domain-containing methyl-accepting chemotaxis protein

COORDINATES: similar to AA sequence:RefSeq:YP_005221075.1
DNA replication terminus site-binding protein

COORDINATES: similar to AA sequence:RefSeq:YP_005221073.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221072.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221071.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221070.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221069.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221068.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221067.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221066.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221065.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221064.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221062.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221061.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221060.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221059.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221058.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221057.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221056.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221054.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221053.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221052.1

COORDINATES: similar to AA sequence:RefSeq:WP_000184110.1

COORDINATES: similar to AA sequence:RefSeq:WP_000071869.1
GO:0002953 - 5'-deoxynucleotidase activity [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_000050847.1

COORDINATES: similar to AA sequence:RefSeq:WP_001187970.1
phosphoadenosine phosphosulfate reductase

COORDINATES: similar to AA sequence:RefSeq:WP_076612015.1
programmed frameshift; Derived by automated computational analysis using gene prediction method: Protein Homology.

COORDINATES: similar to AA sequence:RefSeq:WP_000042274.1

COORDINATES: similar to AA sequence:RefSeq:WP_001093867.1

COORDINATES: similar to AA sequence:RefSeq:WP_011899375.1

COORDINATES: similar to AA sequence:RefSeq:WP_000201432.1
GO:0008168 - methyltransferase activity [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_000410925.1

COORDINATES: similar to AA sequence:RefSeq:WP_000209075.1

COORDINATES: similar to AA sequence:RefSeq:WP_000994741.1

COORDINATES: similar to AA sequence:RefSeq:WP_000651508.1

COORDINATES: similar to AA sequence:RefSeq:WP_000340223.1

COORDINATES: similar to AA sequence:RefSeq:WP_001176699.1

COORDINATES: similar to AA sequence:RefSeq:WP_013141572.1

COORDINATES: similar to AA sequence:RefSeq:WP_001102699.1
GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]
class I ribonucleotide reductase maintenance protein YfaE

COORDINATES: similar to AA sequence:RefSeq:WP_000477209.1

COORDINATES: similar to AA sequence:RefSeq:WP_000793770.1

COORDINATES: similar to AA sequence:RefSeq:WP_000018871.1

COORDINATES: similar to AA sequence:RefSeq:WP_001447572.1

COORDINATES: similar to AA sequence:RefSeq:WP_000039317.1

COORDINATES: similar to AA sequence:RefSeq:WP_000170086.1

COORDINATES: similar to AA sequence:RefSeq:WP_000706865.1

COORDINATES: similar to AA sequence:RefSeq:WP_001282585.1
GO:0006259 - DNA metabolic process [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_000987165.1
GO:0003697 - single-stranded DNA binding [Evidence IEA]
GO:0006310 - DNA recombination [Evidence IEA]; GO:0006281 - DNA repair [Evidence IEA]; GO:0006260 - DNA replication [Evidence IEA]; GO:0006351 - transcription, DNA-templated [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_000739140.1

COORDINATES: similar to AA sequence:RefSeq:WP_000085161.1
CbbQ/NirQ/NorQ C-terminal domain-containing protein

COORDINATES: similar to AA sequence:RefSeq:WP_001186917.1

COORDINATES: similar to AA sequence:RefSeq:WP_000547565.1

COORDINATES: similar to AA sequence:RefSeq:WP_000796664.1

COORDINATES: similar to AA sequence:RefSeq:WP_001909286.1
conjugal transfer mating pair stabilization protein TraN

COORDINATES: similar to AA sequence:RefSeq:WP_005507569.1

COORDINATES: similar to AA sequence:RefSeq:WP_001337754.1

COORDINATES: similar to AA sequence:RefSeq:WP_001447719.1
TrbC family F-type conjugative pilus assembly protein

COORDINATES: similar to AA sequence:RefSeq:WP_001010738.1

COORDINATES: similar to AA sequence:RefSeq:WP_013184404.1

COORDINATES: similar to AA sequence:RefSeq:WP_000637386.1

COORDINATES: similar to AA sequence:RefSeq:WP_001259344.1

COORDINATES: similar to AA sequence:RefSeq:WP_000606833.1

COORDINATES: similar to AA sequence:RefSeq:WP_013141547.1

COORDINATES: similar to AA sequence:RefSeq:WP_010845916.1
type IV conjugative transfer system lipoprotein TraV

COORDINATES: similar to AA sequence:RefSeq:WP_000647304.1

COORDINATES: similar to AA sequence:RefSeq:WP_000794249.1
type-F conjugative transfer system secretin TraK

COORDINATES: similar to AA sequence:RefSeq:WP_001049717.1

COORDINATES: similar to AA sequence:RefSeq:WP_000433889.1
type IV conjugative transfer system protein TraL

COORDINATES: similar to AA sequence:RefSeq:WP_001052531.1

COORDINATES: similar to AA sequence:RefSeq:WP_001275801.1

COORDINATES: similar to AA sequence:RefSeq:WP_001231465.1

COORDINATES: similar to AA sequence:RefSeq:WP_000869261.1

COORDINATES: similar to AA sequence:RefSeq:WP_000743450.1

COORDINATES: similar to AA sequence:RefSeq:WP_000332868.1

COORDINATES: similar to AA sequence:RefSeq:WP_000178858.1
GO:0003674 - molecular_function [Evidence IEA]
Members of this protein family are the putative conjugative coupling factor, TraD, as the term is used for the SXT and TOL plasmid systems; Derived by automated computational analysis using gene prediction method: Protein Homology.
conjugative transfer system coupling protein TraD

COORDINATES: similar to AA sequence:RefSeq:WP_001337757.1

COORDINATES: similar to AA sequence:RefSeq:WP_013184413.1

COORDINATES: similar to AA sequence:RefSeq:WP_010845927.1

COORDINATES: similar to AA sequence:RefSeq:WP_000366822.1
GO:0003677 - DNA binding [Evidence IEA]; GO:0003916 - DNA topoisomerase activity [Evidence IEA]
GO:0006265 - DNA topological change [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:WP_000468105.1

COORDINATES: similar to AA sequence:RefSeq:WP_014386427.1

COORDINATES: similar to AA sequence:RefSeq:WP_000505707.1

COORDINATES: similar to AA sequence:RefSeq:WP_000464631.1

COORDINATES: similar to AA sequence:RefSeq:WP_000362482.1

COORDINATES: similar to AA sequence:RefSeq:WP_000268550.1

COORDINATES: similar to AA sequence:RefSeq:WP_000936896.1

COORDINATES: similar to AA sequence:RefSeq:WP_000647188.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221048.1

COORDINATES: similar to AA sequence:RefSeq:WP_015058947.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221046.1

COORDINATES: similar to AA sequence:RefSeq:WP_000044824.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221044.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221043.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221042.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221041.1
helix-turn-helix domain-containing protein

COORDINATES: similar to AA sequence:RefSeq:YP_005221040.1
GO:0007059 - chromosome segregation [Evidence IEA]; GO:0000910 - cytokinesis [Evidence IEA]
ParB/RepB/Spo0J family partition protein

COORDINATES: similar to AA sequence:RefSeq:YP_005221039.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221037.1

COORDINATES: similar to AA sequence:RefSeq:WP_001043260.1
sulfonamide-resistant dihydropteroate synthase Sul2

COORDINATES: similar to AA sequence:RefSeq:WP_010890156.1
aminoglycoside O-phosphotransferase APH(3'')-Ib

COORDINATES: similar to AA sequence:RefSeq:WP_000480972.1
aminoglycoside O-phosphotransferase APH(6)-Id

COORDINATES: similar to AA sequence:RefSeq:WP_000050481.1
incomplete; partial in the middle of a contig; missing N-terminus and C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology.
transposase zinc-binding domain-containing protein

COORDINATES: similar to AA sequence:RefSeq:WP_000971921.1
IS1182-like element ISCfr1 family transposase

COORDINATES: similar to AA sequence:RefSeq:YP_005221028.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221027.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221025.1

COORDINATES: similar to AA sequence:RefSeq:WP_000557454.1
aminoglycoside N-acetyltransferase AAC(3)-IId

COORDINATES: similar to AA sequence:RefSeq:YP_005221086.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221087.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221088.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221089.1
conjugal transfer protein TraG N-terminal domain-containing protein

COORDINATES: similar to AA sequence:RefSeq:YP_005221090.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221091.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221092.1
transglycosylase SLT domain-containing protein

COORDINATES: similar to AA sequence:RefSeq:YP_005221093.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221094.1
GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IEA]; GO:1902208 - regulation of bacterial-type flagellum assembly [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:YP_005221095.1
GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]

COORDINATES: similar to AA sequence:RefSeq:YP_005221096.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221097.1

COORDINATES: similar to AA sequence:RefSeq:YP_005221098.1