part_of
has db xref: BFO:0000050
has db xref: OBO_REL:part_of
has OBO namespace: gene_ontology
id: part_of
shorthand: part_of
type: ObjectProperty
type: TransitiveProperty

has_part
has db xref: BFO:0000051
has db xref: OBO_REL:has_part
has OBO namespace: gene_ontology
id: has_part
shorthand: has_part
type: ObjectProperty
type: TransitiveProperty

occurs in
has db xref: BFO:0000066
has OBO namespace: gene_ontology
id: occurs_in
shorthand: occurs_in
type: ObjectProperty
property chain axiom: part_of

mitochondrion inheritance
IAO_0000115: The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.
has exact synonym: mitochondrial inheritance
has OBO namespace: biological_process
id: GO:0000001
type: Class
subclass of: GO_0048308
subclass of: GO_0048311

mitochondrial genome maintenance
IAO_0000115: The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
has OBO namespace: biological_process
id: GO:0000002
type: Class
subclass of: GO_0007005

reproduction
IAO_0000115: The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.
has alternative id: GO:0019952
has alternative id: GO:0050876
has db xref: Wikipedia:Reproduction
has exact synonym: reproductive physiological process
has OBO namespace: biological_process
id: GO:0000003
in subset: goslim generic
in subset: goslim pir
in subset: goslim plant
in subset: gosubset prok
type: Class
subclass of: GO_0008150

ribosomal chaperone activity
IAO_0000115: OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function.
consider: GO:0042254
consider: GO:0044183
consider: GO:0051082
has OBO namespace: molecular_function
id: GO:0000005
type: Class
comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function.
deprecated: true

high affinity zinc uptake transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
has OBO namespace: molecular_function
id: GO:0000006
type: Class
subclass of: GO_0005385

low-affinity zinc ion transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
has OBO namespace: molecular_function
id: GO:0000007
type: Class
subclass of: GO_0005385

thioredoxin
IAO_0000115: OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol.
consider: GO:0003756
consider: GO:0015036
has alternative id: GO:0000013
has OBO namespace: molecular_function
id: GO:0000008
type: Class
comment: This term was made obsolete because it represents gene products.
deprecated: true

alpha-1,6-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.
has db xref: EC:2.4.1.-
has db xref: Reactome:REACT_22295
has db xref: Reactome:REACT_22383
has exact synonym: 1,6-alpha-mannosyltransferase activity
has OBO namespace: molecular_function
id: GO:0000009
type: Class
subclass of: mannosyltransferase activity

trans-hexaprenyltranstransferase activity
IAO_0000115: Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate.
has db xref: EC:2.5.1.30
has db xref: KEGG:R05612
has db xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN
has db xref: RHEA:20839
has db xref: RHEA:27797
has exact synonym: all-trans-heptaprenyl-diphosphate synthase activity
has exact synonym: all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity
has exact synonym: heptaprenyl diphosphate synthase activity
has exact synonym: heptaprenyl pyrophosphate synthase activity
has exact synonym: heptaprenyl pyrophosphate synthetase activity
has OBO namespace: molecular_function
id: GO:0000010
in subset: gosubset prok
type: Class
subclass of: GO_0016765

vacuole inheritance
IAO_0000115: The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.
has OBO namespace: biological_process
id: GO:0000011
type: Class
subclass of: GO_0007033
subclass of: GO_0048308

single strand break repair
IAO_0000115: The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.
has OBO namespace: biological_process
id: GO:0000012
in subset: gosubset prok
type: Class
subclass of: GO_0006281

single-stranded DNA specific endodeoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.
has exact synonym: ssDNA-specific endodeoxyribonuclease activity
has OBO namespace: molecular_function
id: GO:0000014
type: Class
subclass of: endodeoxyribonuclease activity

phosphopyruvate hydratase complex
IAO_0000115: A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.
has exact synonym: enolase complex
has OBO namespace: cellular_component
id: GO:0000015
in subset: gosubset prok
type: Class
subclass of: GO_0043234
subclass of: GO_0044445

lactase activity
IAO_0000115: Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.
has broad synonym: lactase-phlorizin hydrolase activity
has db xref: EC:3.2.1.108
has db xref: MetaCyc:LACTASE-RXN
has db xref: RHEA:10079
has db xref: Reactome:REACT_100439
has db xref: Reactome:REACT_104113
has db xref: Reactome:REACT_105850
has db xref: Reactome:REACT_109208
has db xref: Reactome:REACT_109391
has db xref: Reactome:REACT_109447
has db xref: Reactome:REACT_112431
has db xref: Reactome:REACT_114967
has db xref: Reactome:REACT_30821
has db xref: Reactome:REACT_78084
has db xref: Reactome:REACT_78754
has db xref: Reactome:REACT_9455
has exact synonym: lactose galactohydrolase activity
has OBO namespace: molecular_function
id: GO:0000016
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

alpha-glucoside transport
IAO_0000115: The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.
has OBO namespace: biological_process
id: GO:0000017
type: Class
subclass of: GO_0042946

regulation of DNA recombination
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
has OBO namespace: biological_process
id: GO:0000018
in subset: gosubset prok
type: Class
subclass of: GO_0051052
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006310

regulation of mitotic recombination
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
has narrow synonym: regulation of recombination within rDNA repeats
has OBO namespace: biological_process
id: GO:0000019
type: Class
subclass of: regulation of DNA recombination
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006312

negative regulation of recombination within rDNA repeats
IAO_0000115: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.
consider: GO:0045950
has OBO namespace: biological_process
id: GO:0000020
type: Class
comment: This term was made obsolete because it describes a substrate-specific process.
deprecated: true

mitotic spindle elongation
IAO_0000115: Lengthening of the distance between poles of the mitotic spindle.
has exact synonym: spindle elongation during mitosis
has OBO namespace: biological_process
id: GO:0000022
type: Class
subclass of: GO_0051231
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: GO_0007052

maltose metabolic process
IAO_0000115: The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.
has exact synonym: malt sugar metabolic process
has exact synonym: malt sugar metabolism
has exact synonym: maltose metabolism
has OBO namespace: biological_process
id: GO:0000023
in subset: gosubset prok
type: Class
subclass of: GO_0005984

maltose biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).
has exact synonym: malt sugar biosynthesis
has exact synonym: malt sugar biosynthetic process
has exact synonym: maltose anabolism
has exact synonym: maltose biosynthesis
has exact synonym: maltose formation
has exact synonym: maltose synthesis
has OBO namespace: biological_process
id: GO:0000024
in subset: gosubset prok
type: Class
subclass of: maltose metabolic process
subclass of: GO_0046351

maltose catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).
has db xref: MetaCyc:MALTOSECAT-PWY
has exact synonym: malt sugar catabolic process
has exact synonym: malt sugar catabolism
has exact synonym: maltose breakdown
has exact synonym: maltose degradation
has narrow synonym: maltose hydrolysis
has OBO namespace: biological_process
id: GO:0000025
in subset: gosubset prok
type: Class
subclass of: maltose metabolic process
subclass of: GO_0046352

alpha-1,2-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.
has db xref: EC:2.4.1.-
has db xref: Reactome:REACT_22123
has db xref: Reactome:REACT_22156
has db xref: Reactome:REACT_22220
has db xref: Reactome:REACT_22307
has OBO namespace: molecular_function
id: GO:0000026
type: Class
subclass of: mannosyltransferase activity

ribosomal large subunit assembly
IAO_0000115: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
has narrow synonym: 50S ribosomal subunit assembly
has narrow synonym: 60S ribosomal subunit assembly
has OBO namespace: biological_process
id: GO:0000027
in subset: gosubset prok
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0042255
subclass of: Restriction
  on property: part_of
  some values from: GO_0042273

ribosomal small subunit assembly
IAO_0000115: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
has narrow synonym: 30S ribosomal subunit assembly
has narrow synonym: 40S ribosomal subunit assembly
has OBO namespace: biological_process
id: GO:0000028
in subset: gosubset prok
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0042274
subclass of: Restriction
  on property: part_of
  some values from: GO_0042255

mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
has db xref: EC:2.4.1.-
has db xref: Reactome:REACT_1018
has db xref: Reactome:REACT_105204
has db xref: Reactome:REACT_2179
has db xref: Reactome:REACT_22117
has db xref: Reactome:REACT_30252
has db xref: Reactome:REACT_34702
has db xref: Reactome:REACT_63412
has db xref: Reactome:REACT_87972
has db xref: Reactome:REACT_95740
has OBO namespace: molecular_function
id: GO:0000030
in subset: gosubset prok
type: Class
subclass of: GO_0016758

mannosylphosphate transferase activity
IAO_0000115: Catalysis of the transfer of a mannosylphosphate group from one compound to another.
has OBO namespace: molecular_function
id: GO:0000031
type: Class
subclass of: GO_0016740

cell wall mannoprotein biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
has exact synonym: cell wall mannoprotein anabolism
has exact synonym: cell wall mannoprotein biosynthesis
has exact synonym: cell wall mannoprotein formation
has exact synonym: cell wall mannoprotein synthesis
has OBO namespace: biological_process
id: GO:0000032
in subset: gosubset prok
type: Class
subclass of: GO_0006057
subclass of: GO_0031506

alpha-1,3-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.
has db xref: EC:2.4.1.-
has db xref: Reactome:REACT_22347
has db xref: Reactome:REACT_22415
has OBO namespace: molecular_function
id: GO:0000033
type: Class
subclass of: mannosyltransferase activity

adenine deaminase activity
IAO_0000115: Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3.
has db xref: EC:3.5.4.2
has db xref: MetaCyc:ADENINE-DEAMINASE-RXN
has db xref: RHEA:23691
has exact synonym: ADase activity
has exact synonym: adenase activity
has exact synonym: adenine aminase activity
has exact synonym: adenine aminohydrolase activity
has OBO namespace: molecular_function
id: GO:0000034
in subset: gosubset prok
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

acyl binding
IAO_0000115: Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
has broad synonym: acyl-CoA or acyl binding
has OBO namespace: molecular_function
id: GO:0000035
in subset: gosubset prok
type: Class
subclass of: GO_0005488

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
IAO_0000115: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.
has exact synonym: acyl carrier activity
has OBO namespace: molecular_function
id: GO:0000036
in subset: gosubset prok
type: Class
comment: Note that this term was moved from transporter to binding because we decided that ACP is not a true transporter, but instead tethers the growing entity that is acted on to make the fatty acid, so binding is the more correct parent. July 2012.
subclass of: GO_0044620

very long-chain fatty acid metabolic process
IAO_0000115: The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
has exact synonym: very long chain fatty acid metabolic process
has exact synonym: very-long-chain fatty acid metabolic process
has exact synonym: very-long-chain fatty acid metabolism
has OBO namespace: biological_process
id: GO:0000038
in subset: gosubset prok
type: Class
subclass of: GO_0006631

plasma membrane long-chain fatty acid transporter
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0005324
consider: GO:0005886
has OBO namespace: molecular_function
id: GO:0000039
type: Class
comment: This term was made obsolete because it describes a gene product and it contains component information.
deprecated: true

low-affinity iron ion transport
IAO_0000115: The directed, low-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations.
has exact synonym: low affinity iron ion transport
has OBO namespace: biological_process
id: GO:0000040
type: Class
subclass of: GO_0034755

transition metal ion transport
IAO_0000115: The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
has exact synonym: transition metal transport
has OBO namespace: biological_process
id: GO:0000041
in subset: gosubset prok
type: Class
subclass of: GO_0030001

protein targeting to Golgi
IAO_0000115: The process of directing proteins towards the Golgi; usually uses signals contained within the protein.
has exact synonym: protein-Golgi targeting
has OBO namespace: biological_process
id: GO:0000042
type: Class
subclass of: retrograde transport, vesicle recycling within Golgi
subclass of: GO_0006605
subclass of: GO_0072600

ascorbate stabilization
IAO_0000115: OBSOLETE. The reduction of the ascorbate free radical to a stable form.
has exact synonym: vitamin C stabilization
has OBO namespace: biological_process
id: GO:0000044
type: Class
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
deprecated: true

autophagic vacuole assembly
IAO_0000115: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
has exact synonym: autophagosome biosynthesis
has exact synonym: autophagosome formation
has narrow synonym: PAS formation
has OBO namespace: biological_process
has related synonym: autophagic vacuole formation
id: GO:0000045
type: Class
subclass of: GO_0007033
subclass of: GO_0070925
subclass of: Restriction
  on property: part_of
  some values from: GO_0016236

autophagic vacuole fusion
IAO_0000115: The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole.
has narrow synonym: fusion of autophagosome with lysosome
has OBO namespace: biological_process
id: GO:0000046
type: Class
subclass of: GO_0048284
subclass of: GO_0090174
subclass of: Restriction
  on property: part_of
  some values from: GO_0016236

Rieske iron-sulfur protein
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0009055
has exact synonym: Rieske iron-sulphur protein
has OBO namespace: molecular_function
id: GO:0000047
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

peptidyltransferase activity
IAO_0000115: Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2).
has db xref: EC:2.3.2.12
has db xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
has db xref: Reactome:REACT_102632
has db xref: Reactome:REACT_104123
has db xref: Reactome:REACT_112282
has db xref: Reactome:REACT_115501
has db xref: Reactome:REACT_1227
has db xref: Reactome:REACT_28090
has db xref: Reactome:REACT_31656
has db xref: Reactome:REACT_33679
has db xref: Reactome:REACT_77497
has db xref: Reactome:REACT_81539
has db xref: Reactome:REACT_87719
has db xref: Reactome:REACT_90185
has db xref: Reactome:REACT_90457
has db xref: Reactome:REACT_91228
has db xref: Reactome:REACT_95405
has db xref: Reactome:REACT_98179
has exact synonym: peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity
has OBO namespace: molecular_function
id: GO:0000048
type: Class
subclass of: GO_0016755

tRNA binding
IAO_0000115: Interacting selectively and non-covalently with transfer RNA.
has OBO namespace: molecular_function
id: GO:0000049
in subset: gosubset prok
type: Class
subclass of: RNA binding

urea cycle
IAO_0000115: The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
has alternative id: GO:0006594
has alternative id: GO:0006871
has db xref: Reactome:REACT_100599
has db xref: Reactome:REACT_107747
has db xref: Reactome:REACT_109525
has db xref: Reactome:REACT_31787
has db xref: Reactome:REACT_32463
has db xref: Reactome:REACT_32971
has db xref: Reactome:REACT_33119
has db xref: Reactome:REACT_78616
has db xref: Reactome:REACT_80089
has db xref: Reactome:REACT_81058
has db xref: Reactome:REACT_82995
has db xref: Reactome:REACT_83831
has db xref: Reactome:REACT_84694
has db xref: Reactome:REACT_847
has db xref: Reactome:REACT_88394
has db xref: Reactome:REACT_90218
has db xref: Reactome:REACT_90565
has db xref: Reactome:REACT_92378
has db xref: Reactome:REACT_95880
has db xref: Reactome:REACT_97366
has db xref: Reactome:REACT_98985
has db xref: Wikipedia:Urea_cycle
has exact synonym: ornithine cycle
has exact synonym: urea biosynthesis
has exact synonym: urea biosynthetic process
has OBO namespace: biological_process
id: GO:0000050
type: Class
subclass of: GO_0019627
subclass of: GO_0043604
subclass of: GO_1901576

urea cycle intermediate metabolic process
IAO_0000115: OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
has exact synonym: urea cycle intermediate metabolism
has OBO namespace: biological_process
id: GO:0000051
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
deprecated: true

citrulline metabolic process
IAO_0000115: The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
has exact synonym: citrulline metabolism
has OBO namespace: biological_process
id: GO:0000052
in subset: gosubset prok
type: Class
subclass of: GO_0006575
subclass of: GO_1901605

argininosuccinate metabolic process
IAO_0000115: The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.
has exact synonym: argininosuccinate metabolism
has OBO namespace: biological_process
id: GO:0000053
type: Class
subclass of: GO_0006575
subclass of: GO_0072350

ribosomal subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
has exact synonym: ribosomal subunit export from cell nucleus
has exact synonym: ribosomal subunit export out of nucleus
has exact synonym: ribosomal subunit transport from nucleus to cytoplasm
has exact synonym: ribosomal subunit-nucleus export
has OBO namespace: biological_process
has related synonym: ribosome export from nucleus
id: GO:0000054
in subset: goslim yeast
type: Class
subclass of: GO_0033753
subclass of: GO_0051168
subclass of: GO_0071428
subclass of: Restriction
  on property: part_of
  some values from: GO_0042254

ribosomal large subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
has alternative id: GO:0000057
has exact synonym: ribosomal large subunit export from cell nucleus
has exact synonym: ribosomal large subunit export out of nucleus
has exact synonym: ribosomal large subunit transport from nucleus to cytoplasm
has exact synonym: ribosomal large subunit-nucleus export
has narrow synonym: 50S ribosomal subunit export from nucleus
has narrow synonym: 60S ribosomal subunit export from nucleus
has OBO namespace: biological_process
id: GO:0000055
type: Class
subclass of: ribosomal subunit export from nucleus

ribosomal small subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
has alternative id: GO:0000058
has exact synonym: ribosomal small subunit export from cell nucleus
has exact synonym: ribosomal small subunit export out of nucleus
has exact synonym: ribosomal small subunit transport from nucleus to cytoplasm
has exact synonym: ribosomal small subunit-nucleus export
has narrow synonym: 30S ribosomal subunit export from nucleus
has narrow synonym: 40S ribosomal subunit export from nucleus
has OBO namespace: biological_process
id: GO:0000056
type: Class
subclass of: ribosomal subunit export from nucleus

protein import into nucleus, docking
IAO_0000115: A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex.
has exact synonym: protein docking during protein import into nucleus
has exact synonym: protein docking during protein transport from cytoplasm to nucleus
has exact synonym: protein docking during protein-nucleus import
has exact synonym: protein transport from cytoplasm to nucleus, docking
has exact synonym: protein-nucleus import, docking
has OBO namespace: biological_process
id: GO:0000059
type: Class
subclass of: GO_0043623
subclass of: Restriction
  on property: part_of
  some values from: GO_0006606

protein import into nucleus, translocation
IAO_0000115: A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
has exact synonym: protein import into cell nucleus, translocation
has exact synonym: protein translocation during protein import into nucleus
has exact synonym: protein translocation during protein transport from cytoplasm to nucleus
has exact synonym: protein translocation during protein-nucleus import
has exact synonym: protein transport from cytoplasm to nucleus, translocation
has exact synonym: protein-nucleus import, translocation
has OBO namespace: biological_process
id: GO:0000060
type: Class
comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
subclass of: GO_0006886
subclass of: Restriction
  on property: part_of
  some values from: GO_0006606

protein import into nucleus, substrate release
IAO_0000115: A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex.
has exact synonym: protein import into cell nucleus, substrate release
has exact synonym: protein substrate release during protein import into nucleus
has exact synonym: protein substrate release during protein transport from cytoplasm to nucleus
has exact synonym: protein substrate release during protein-nucleus import
has exact synonym: protein transport from cytoplasm to nucleus, substrate release
has exact synonym: protein-nucleus import, substrate release
has OBO namespace: biological_process
id: GO:0000061
type: Class
subclass of: GO_0043624
subclass of: Restriction
  on property: part_of
  some values from: GO_0006606

fatty-acyl-CoA binding
IAO_0000115: Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
has broad synonym: acyl-CoA or acyl binding
has OBO namespace: molecular_function
id: GO:0000062
in subset: gosubset prok
type: Class
subclass of: GO_0043168
subclass of: GO_0050662

L-ornithine transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.
has broad synonym: L-ornithine transporter activity
has db xref: Reactome:REACT_100602
has db xref: Reactome:REACT_102399
has db xref: Reactome:REACT_103552
has db xref: Reactome:REACT_103610
has db xref: Reactome:REACT_104169
has db xref: Reactome:REACT_109285
has db xref: Reactome:REACT_115531
has db xref: Reactome:REACT_151
has db xref: Reactome:REACT_28177
has db xref: Reactome:REACT_30708
has db xref: Reactome:REACT_78308
has db xref: Reactome:REACT_84383
has db xref: Reactome:REACT_88886
has db xref: Reactome:REACT_88959
has db xref: Reactome:REACT_90007
has OBO namespace: molecular_function
has related synonym: histidine/arginine/lysine/ornithine porter activity
id: GO:0000064
in subset: gosubset prok
type: Class
subclass of: GO_0008324
subclass of: GO_0015179

mitochondrial ornithine transport
IAO_0000115: The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion.
has OBO namespace: biological_process
id: GO:0000066
type: Class
subclass of: GO_0006839
subclass of: GO_0015822

DNA replication and chromosome cycle
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0006260
consider: GO:0007059
consider: GO:0051276
has OBO namespace: biological_process
id: GO:0000067
type: Class
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
deprecated: true

mitotic sister chromatid segregation
IAO_0000115: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
has alternative id: GO:0016359
has exact synonym: mitotic chromosome segregation
has narrow synonym: mitotic sister-chromatid adhesion release
has OBO namespace: biological_process
id: GO:0000070
type: Class
subclass of: sister chromatid segregation
subclass of: Restriction
  on property: part_of
  some values from: GO_0007067
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle

M phase specific microtubule process
IAO_0000115: A microtubule-based process that occurs only during M phase of the cell cycle.
has exact synonym: M-phase specific microtubule process
has OBO namespace: biological_process
id: GO:0000072
type: Class
subclass of: GO_0007017
subclass of: Restriction
  on property: part_of
  some values from: M phase

spindle pole body separation
IAO_0000115: A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble.
has alternative id: GO:0030475
has OBO namespace: biological_process
id: GO:0000073
type: Class
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: GO_0051300

cell cycle checkpoint
IAO_0000115: A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect.
has db xref: Reactome:REACT_100401
has db xref: Reactome:REACT_102145
has db xref: Reactome:REACT_102175
has db xref: Reactome:REACT_106487
has db xref: Reactome:REACT_109101
has db xref: Reactome:REACT_1538
has db xref: Reactome:REACT_29957
has db xref: Reactome:REACT_31789
has db xref: Reactome:REACT_33305
has db xref: Reactome:REACT_79078
has db xref: Reactome:REACT_84460
has db xref: Reactome:REACT_89660
has db xref: Reactome:REACT_90285
has db xref: Reactome:REACT_90465
has db xref: Reactome:REACT_92239
has db xref: Reactome:REACT_96499
has db xref: Reactome:REACT_99737
has db xref: Wikipedia:Cell_cycle_checkpoint
has OBO namespace: biological_process
id: GO:0000075
type: Class
subclass of: GO_0071156
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0007050

DNA replication checkpoint
IAO_0000115: A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
has OBO namespace: biological_process
id: GO:0000076
type: Class
subclass of: GO_0010972
subclass of: GO_0031570

DNA damage checkpoint
IAO_0000115: A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
has db xref: Wikipedia:DNA_damage_checkpoint
has db xref: Wikipedia:Postreplication_checkpoint
has narrow synonym: DNA damage response, signal transduction resulting in cell cycle arrest
has OBO namespace: biological_process
id: GO:0000077
type: Class
subclass of: GO_0006974
subclass of: GO_0031570

cell shape checkpoint
IAO_0000115: A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular shaping and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective.
has exact synonym: cell morphogenesis checkpoint
has OBO namespace: biological_process
id: GO:0000078
type: Class
subclass of: GO_0007093

regulation of cyclin-dependent protein kinase activity
IAO_0000115: Any process that modulates the frequency, rate or extent of CDK activity.
has exact synonym: regulation of CDK activity
has OBO namespace: biological_process
id: GO:0000079
type: Class
subclass of: GO_0051726
subclass of: GO_0071900

G1 phase of mitotic cell cycle
IAO_0000115: G1 phase occurring as part of the mitotic cell cycle. G1 phase is the interval between the completion of DNA segregation (mitosis in a mitotic cell cycle) and the beginning of DNA synthesis. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells.
has db xref: Reactome:REACT_101162
has db xref: Reactome:REACT_1590
has db xref: Reactome:REACT_29795
has db xref: Reactome:REACT_34060
has db xref: Reactome:REACT_78665
has db xref: Reactome:REACT_78866
has db xref: Reactome:REACT_83686
has db xref: Reactome:REACT_91654
has db xref: Reactome:REACT_93384
has db xref: Reactome:REACT_93574
has OBO namespace: biological_process
id: GO:0000080
type: Class
subclass of: GO_0051318
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

G1/S transition of mitotic cell cycle
IAO_0000115: Progression from G1 phase to S phase of the mitotic cell cycle.
has db xref: Reactome:REACT_101799
has db xref: Reactome:REACT_102687
has db xref: Reactome:REACT_104020
has db xref: Reactome:REACT_104529
has db xref: Reactome:REACT_104577
has db xref: Reactome:REACT_106054
has db xref: Reactome:REACT_107492
has db xref: Reactome:REACT_109784
has db xref: Reactome:REACT_109821
has db xref: Reactome:REACT_110917
has db xref: Reactome:REACT_1783
has db xref: Reactome:REACT_28713
has db xref: Reactome:REACT_45711
has db xref: Reactome:REACT_84226
has db xref: Reactome:REACT_85355
has db xref: Reactome:REACT_87037
has db xref: Reactome:REACT_88046
has db xref: Reactome:REACT_95294
has OBO namespace: biological_process
id: GO:0000082
type: Class
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

regulation of transcription involved in G1/S phase of mitotic cell cycle
IAO_0000115: Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle.
has db xref: Reactome:REACT_683
has exact synonym: regulation of transcription involved in G1/S-phase of mitotic cell cycle
has OBO namespace: biological_process
has related synonym: G1/S-specific transcription in mitotic cell cycle
has related synonym: regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle
id: GO:0000083
type: Class
subclass of: GO_0006357
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: G1/S transition of mitotic cell cycle

S phase of mitotic cell cycle
IAO_0000115: S phase occurring as part of the mitotic cell cycle. S phase is the part of the cell cycle during which DNA synthesis takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells.
has db xref: Reactome:REACT_105829
has db xref: Reactome:REACT_108550
has db xref: Reactome:REACT_110039
has db xref: Reactome:REACT_28988
has db xref: Reactome:REACT_32013
has db xref: Reactome:REACT_34043
has db xref: Reactome:REACT_78838
has db xref: Reactome:REACT_78845
has db xref: Reactome:REACT_81914
has db xref: Reactome:REACT_82813
has db xref: Reactome:REACT_85811
has db xref: Reactome:REACT_89318
has db xref: Reactome:REACT_899
has db xref: Reactome:REACT_92500
has db xref: Reactome:REACT_92759
has db xref: Reactome:REACT_95174
has db xref: Reactome:REACT_96081
has db xref: Reactome:REACT_97603
has db xref: Reactome:REACT_99645
has exact synonym: S-phase of mitotic cell cycle
has OBO namespace: biological_process
id: GO:0000084
type: Class
subclass of: GO_0051320
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

G2 phase of mitotic cell cycle
IAO_0000115: G2 phase occurring as part of the mitotic cell cycle. G2 phase is the interval between the completion of DNA synthesis and the beginning of DNA segregation (mitosis in a mitotic cell cycle). A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells.
has db xref: Reactome:REACT_105223
has db xref: Reactome:REACT_105307
has db xref: Reactome:REACT_106415
has db xref: Reactome:REACT_106836
has db xref: Reactome:REACT_1915
has db xref: Reactome:REACT_28975
has db xref: Reactome:REACT_85928
has db xref: Reactome:REACT_96332
has OBO namespace: biological_process
id: GO:0000085
type: Class
subclass of: GO_0051319
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

G2/M transition of mitotic cell cycle
IAO_0000115: Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (e.g. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
has db xref: Reactome:REACT_100942
has db xref: Reactome:REACT_103766
has db xref: Reactome:REACT_107882
has db xref: Reactome:REACT_114616
has db xref: Reactome:REACT_2203
has db xref: Reactome:REACT_28929
has db xref: Reactome:REACT_30388
has db xref: Reactome:REACT_34062
has db xref: Reactome:REACT_77778
has db xref: Reactome:REACT_83880
has db xref: Reactome:REACT_87036
has db xref: Reactome:REACT_87230
has db xref: Reactome:REACT_87807
has db xref: Reactome:REACT_88018
has db xref: Reactome:REACT_88369
has db xref: Reactome:REACT_92702
has OBO namespace: biological_process
id: GO:0000086
type: Class
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

M phase of mitotic cell cycle
IAO_0000115: M phase occurring as part of the mitotic cell cycle. M phase is the part of the cell cycle during which nuclear division takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells.
has db xref: Reactome:REACT_105412
has db xref: Reactome:REACT_107095
has db xref: Reactome:REACT_109059
has db xref: Reactome:REACT_29488
has db xref: Reactome:REACT_33490
has db xref: Reactome:REACT_82055
has db xref: Reactome:REACT_87132
has db xref: Reactome:REACT_88263
has db xref: Reactome:REACT_910
has db xref: Reactome:REACT_92998
has db xref: Reactome:REACT_93131
has db xref: Reactome:REACT_93566
has db xref: Reactome:REACT_93720
has db xref: Reactome:REACT_94536
has exact synonym: M-phase of mitotic cell cycle
has OBO namespace: biological_process
id: GO:0000087
type: Class
subclass of: M phase
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle

mitotic prophase
IAO_0000115: Prophase occurring as part of mitosis. Prophase is the part of nuclear division in which, canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell.
has db xref: Reactome:REACT_100605
has db xref: Reactome:REACT_102122
has db xref: Reactome:REACT_105127
has db xref: Reactome:REACT_106058
has db xref: Reactome:REACT_28443
has db xref: Reactome:REACT_28607
has db xref: Reactome:REACT_32677
has db xref: Reactome:REACT_765
has db xref: Reactome:REACT_79474
has db xref: Reactome:REACT_80300
has db xref: Reactome:REACT_83888
has db xref: Reactome:REACT_90347
has db xref: Reactome:REACT_90481
has OBO namespace: biological_process
id: GO:0000088
type: Class
subclass of: GO_0051324
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: GO_0007067

mitotic metaphase
IAO_0000115: Metaphase occurring as part of mitosis. Metaphase is the part of nuclear division in which, canonically, chromosomes become aligned on the equatorial plate of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell.
has db xref: Reactome:REACT_434
has OBO namespace: biological_process
id: GO:0000089
type: Class
subclass of: GO_0051323
subclass of: Restriction
  on property: part_of
  some values from: GO_0007067
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle

mitotic anaphase
IAO_0000115: Anaphase occurring as part of mitosis. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell.
has db xref: Reactome:REACT_1275
has OBO namespace: biological_process
id: GO:0000090
type: Class
subclass of: GO_0051322
subclass of: Restriction
  on property: part_of
  some values from: GO_0007067
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle

mitotic anaphase A
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles.
has OBO namespace: biological_process
id: GO:0000091
type: Class
subclass of: mitotic anaphase

mitotic anaphase B
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart.
has OBO namespace: biological_process
id: GO:0000092
type: Class
subclass of: mitotic anaphase

mitotic telophase
IAO_0000115: Telophase occurring as part of mitosis. Telophase is the part of nuclear division that, canonically, begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell.
has OBO namespace: biological_process
id: GO:0000093
type: Class
subclass of: GO_0051326
subclass of: Restriction
  on property: part_of
  some values from: GO_0007067
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle

septin assembly and septum formation
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0000917
consider: GO:0000918
consider: GO:0000921
has OBO namespace: biological_process
id: GO:0000094
type: Class
comment: This term was made obsolete because it was not defined and the string name implied two separate processes.
deprecated: true

S-adenosylmethionine transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
has alternative id: GO:0015177
has broad synonym: S-adenosylmethionine transporter activity
has exact synonym: S-adenosyl methionine permease activity
has exact synonym: S-adenosyl methionine transporter activity
has exact synonym: S-adenosylmethionine permease activity
has OBO namespace: molecular_function
id: GO:0000095
type: Class
subclass of: GO_0015211
subclass of: GO_0051185
subclass of: GO_0072349
subclass of: GO_1901682

sulfur amino acid metabolic process
IAO_0000115: The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
has db xref: Reactome:REACT_115639
has db xref: Reactome:REACT_118084
has db xref: Reactome:REACT_118094
has db xref: Reactome:REACT_118099
has db xref: Reactome:REACT_118166
has db xref: Reactome:REACT_118184
has db xref: Reactome:REACT_118203
has db xref: Reactome:REACT_118227
has db xref: Reactome:REACT_118256
has db xref: Reactome:REACT_118291
has db xref: Reactome:REACT_118309
has db xref: Reactome:REACT_118314
has db xref: Reactome:REACT_118323
has db xref: Reactome:REACT_118328
has db xref: Reactome:REACT_118349
has db xref: Reactome:REACT_118370
has db xref: Reactome:REACT_118388
has db xref: Reactome:REACT_118463
has db xref: Reactome:REACT_118518
has db xref: Reactome:REACT_118541
has db xref: Reactome:REACT_27187
has exact synonym: sulfur amino acid metabolism
has exact synonym: sulphur amino acid metabolic process
has exact synonym: sulphur amino acid metabolism
has OBO namespace: biological_process
id: GO:0000096
in subset: gosubset prok
type: Class
subclass of: GO_0006520
subclass of: GO_0006790

sulfur amino acid biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid anabolism
has exact synonym: sulfur amino acid biosynthesis
has exact synonym: sulfur amino acid formation
has exact synonym: sulfur amino acid synthesis
has exact synonym: sulphur amino acid biosynthesis
has exact synonym: sulphur amino acid biosynthetic process
has OBO namespace: biological_process
id: GO:0000097
in subset: gosubset prok
type: Class
subclass of: sulfur amino acid metabolic process
subclass of: GO_0008652
subclass of: GO_0044272

sulfur amino acid catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.
has db xref: Reactome:REACT_115654
has exact synonym: sulfur amino acid breakdown
has exact synonym: sulfur amino acid catabolism
has exact synonym: sulfur amino acid degradation
has exact synonym: sulphur amino acid catabolic process
has exact synonym: sulphur amino acid catabolism
has OBO namespace: biological_process
id: GO:0000098
in subset: gosubset prok
type: Class
subclass of: sulfur amino acid metabolic process
subclass of: GO_0009063
subclass of: GO_0044273

sulfur amino acid transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives.
has broad synonym: sulfur amino acid transporter activity
has broad synonym: sulphur amino acid transporter activity
has exact synonym: sulphur amino acid transmembrane transporter activity
has OBO namespace: molecular_function
id: GO:0000099
in subset: gosubset prok
type: Class
subclass of: GO_0015171
subclass of: GO_1901682

S-methylmethionine transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other.
has alternative id: GO:0015178
has broad synonym: S-methylmethionine transporter activity
has exact synonym: S-methylmethionine permease activity
has OBO namespace: molecular_function
id: GO:0000100
in subset: gosubset prok
type: Class
subclass of: sulfur amino acid transmembrane transporter activity
subclass of: GO_0072349

sulfur amino acid transport
IAO_0000115: The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: sulphur amino acid transport
has OBO namespace: biological_process
id: GO:0000101
in subset: gosubset prok
type: Class
subclass of: GO_0006865
subclass of: GO_0072348

L-methionine secondary active transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
has OBO namespace: molecular_function
has related synonym: L-methionine porter activity
id: GO:0000102
type: Class
subclass of: GO_0005294
subclass of: GO_0015191
subclass of: GO_1901680

sulfate assimilation
IAO_0000115: The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.
has alternative id: GO:0019378
has db xref: Reactome:REACT_27155
has exact synonym: sulphate assimilation
has narrow synonym: sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor
has narrow synonym: sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor
has OBO namespace: biological_process
id: GO:0000103
in subset: gosubset prok
type: Class
subclass of: GO_0006790

succinate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.
has alternative id: GO:0019739
has broad synonym: succinic dehydrogenase activity
has db xref: EC:1.3.99.1
has db xref: MetaCyc:SUCC-FUM-OXRED-RXN
has db xref: RHEA:16360
has exact synonym: fumarate dehydrogenase activity
has exact synonym: fumarate reductase activity
has exact synonym: fumaric hydrogenase activity
has exact synonym: succinate oxidoreductase activity
has exact synonym: succinate:(acceptor) oxidoreductase activity
has exact synonym: succinate:acceptor oxidoreductase activity
has exact synonym: succinic acid dehydrogenase activity
has exact synonym: succinodehydrogenase activity
has exact synonym: succinyl dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0000104
in subset: gosubset prok
type: Class
subclass of: GO_0016627

histidine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
has db xref: MetaCyc:HISTSYN-PWY
has exact synonym: histidine anabolism
has exact synonym: histidine biosynthesis
has exact synonym: histidine formation
has exact synonym: histidine synthesis
has OBO namespace: biological_process
id: GO:0000105
in subset: gosubset prok
type: Class
subclass of: GO_0006547
subclass of: GO_0009076
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_1901362
subclass of: GO_1901607

imidazoleglycerol-phosphate synthase activity
IAO_0000115: Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+).
has broad synonym: glutamine amidotransferase:cyclase activity
has db xref: EC:2.4.2.-
has db xref: MetaCyc:GLUTAMIDOTRANS-RXN
has exact synonym: imidazole glycerol phosphate synthase activity
has exact synonym: imidazoleglycerol phosphate synthase activity
has OBO namespace: molecular_function
has related synonym: imidazole-glycerol-phosphate synthase activity
id: GO:0000107
in subset: gosubset prok
type: Class
subclass of: GO_0016763

repairosome
IAO_0000115: OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage.
IAO_0100001: GO:0000109
has OBO namespace: cellular_component
id: GO:0000108
type: Class
comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators.
deprecated: true

nucleotide-excision repair complex
IAO_0000115: Any complex formed of proteins that act in nucleotide-excision repair.
has OBO namespace: cellular_component
id: GO:0000109
in subset: goslim pir
type: Class
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
subclass of: GO_0043234
subclass of: GO_0044428

nucleotide-excision repair factor 1 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
has exact synonym: NEF1 complex
has exact synonym: XPA-ERCC1-ERCC4 complex
has OBO namespace: cellular_component
id: GO:0000110
type: Class
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
subclass of: nucleotide-excision repair complex

nucleotide-excision repair factor 2 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.
has exact synonym: NEF2 complex
has OBO namespace: cellular_component
id: GO:0000111
type: Class
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
subclass of: nucleotide-excision repair complex

nucleotide-excision repair factor 3 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p).
has exact synonym: NEF3 complex
has OBO namespace: cellular_component
id: GO:0000112
type: Class
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
subclass of: nucleotide-excision repair complex

nucleotide-excision repair factor 4 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.
has exact synonym: NEF4 complex
has OBO namespace: cellular_component
id: GO:0000113
type: Class
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
subclass of: nucleotide-excision repair complex

regulation of transcription involved in G1 phase of mitotic cell cycle
IAO_0000115: Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle.
has exact synonym: regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle
has OBO namespace: biological_process
has related synonym: G1-specific transcription in mitotic cell cycle
id: GO:0000114
type: Class
subclass of: GO_0006357
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: G1 phase of mitotic cell cycle

regulation of transcription involved in S phase of mitotic cell cycle
IAO_0000115: A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle.
has exact synonym: S-specific transcription in mitotic cell cycle
has exact synonym: regulation of transcription involved in S-phase of mitotic cell cycle
has OBO namespace: biological_process
has related synonym: S-phase-specific transcription in mitotic cell cycle
has related synonym: regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle
id: GO:0000115
type: Class
subclass of: GO_0006357
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: S phase of mitotic cell cycle

regulation of transcription involved in G2-phase of mitotic cell cycle
IAO_0000115: Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle.
has OBO namespace: biological_process
has related synonym: G2-specific transcription in mitotic cell cycle
has related synonym: regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle
id: GO:0000116
type: Class
subclass of: GO_0006357
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: G2 phase of mitotic cell cycle

regulation of transcription involved in G2/M-phase of mitotic cell cycle
IAO_0000115: Any process that regulates transcription such that the target genes are transcribed as part of the G2/M phase of the mitotic cell cycle.
has OBO namespace: biological_process
has related synonym: G2/M-specific transcription in mitotic cell cycle
has related synonym: regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle
id: GO:0000117
type: Class
subclass of: GO_0006357
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: G2/M transition of mitotic cell cycle

histone deacetylase complex
IAO_0000115: A protein complex that possesses histone deacetylase activity.
has exact synonym: HDAC complex
has OBO namespace: cellular_component
id: GO:0000118
type: Class
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
subclass of: GO_0016585
subclass of: GO_0044451

RNA polymerase I transcription factor complex
IAO_0000115: A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I.
has OBO namespace: cellular_component
id: GO:0000120
type: Class
subclass of: GO_0005667
subclass of: GO_0044452

glycerol-1-phosphatase activity
IAO_0000115: Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.
has db xref: EC:3.1.3.21
has db xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
has db xref: RHEA:11479
has exact synonym: alpha-glycerol phosphatase activity
has exact synonym: alpha-glycerophosphatase activity
has exact synonym: glycerol 3-phosphatase activity
has exact synonym: glycerol 3-phosphate phosphohydrolase activity
has exact synonym: glycerol-1-phosphate phosphohydrolase activity
has exact synonym: glycerol-3-phosphate phosphatase activity
has OBO namespace: molecular_function
id: GO:0000121
type: Class
subclass of: GO_0016791

negative regulation of transcription from RNA polymerase II promoter
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has alternative id: GO:0010553
has alternative id: GO:0045816
has exact synonym: down regulation of transcription from RNA polymerase II promoter
has exact synonym: down-regulation of transcription from RNA polymerase II promoter
has exact synonym: downregulation of transcription from RNA polymerase II promoter
has exact synonym: inhibition of transcription from RNA polymerase II promoter
has exact synonym: negative regulation of transcription from Pol II promoter
has OBO namespace: biological_process
has related synonym: down regulation of global transcription from RNA polymerase II promoter
has related synonym: down-regulation of global transcription from RNA polymerase II promoter
has related synonym: downregulation of global transcription from RNA polymerase II promoter
has related synonym: inhibition of global transcription from RNA polymerase II promoter
has related synonym: negative regulation of gene-specific transcription from RNA polymerase II promoter
has related synonym: negative regulation of global transcription from Pol II promoter
has related synonym: negative regulation of transcription from RNA polymerase II promoter, global
id: GO:0000122
type: Class
subclass of: GO_0006357
subclass of: GO_0045892
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0006366

histone acetyltransferase complex
IAO_0000115: A protein complex that possesses histone acetyltransferase activity.
has exact synonym: histone acetylase complex
has OBO namespace: cellular_component
id: GO:0000123
type: Class
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
subclass of: GO_0043234
subclass of: GO_0044451

SAGA complex
IAO_0000115: A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery.
has exact synonym: Spt-Ada-Gcn5-acetyltransferase complex
has OBO namespace: cellular_component
id: GO:0000124
type: Class
subclass of: GO_0016585
subclass of: GO_0070461

PCAF complex
IAO_0000115: A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
has exact synonym: PCAF histone acetylase-associated complex
has exact synonym: SPT3-TAF9-PCAF acetylase complex
has OBO namespace: cellular_component
id: GO:0000125
type: Class
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
subclass of: GO_0070461

transcription factor TFIIIB complex
IAO_0000115: A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
has OBO namespace: cellular_component
id: GO:0000126
type: Class
subclass of: GO_0005667

transcription factor TFIIIC complex
IAO_0000115: A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.
has OBO namespace: cellular_component
id: GO:0000127
type: Class
subclass of: GO_0005667

flocculation
IAO_0000115: The reversible, calcium-dependent non-sexual aggregation of single-celled organisms.
has db xref: Wikipedia:Flocculation
has OBO namespace: biological_process
id: GO:0000128
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0044764

incipient cellular bud site
IAO_0000115: The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
has OBO namespace: cellular_component
id: GO:0000131
type: Class
subclass of: GO_0044424

establishment of mitotic spindle orientation
IAO_0000115: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
has alternative id: GO:0030607
has alternative id: GO:0030609
has exact synonym: establishment of spindle orientation involved in mitotic cell cycle
has exact synonym: mitotic spindle orientation
has exact synonym: orienting of mitotic spindle
has OBO namespace: biological_process
has related synonym: establishment of spindle orientation during mitosis
id: GO:0000132
type: Class
subclass of: GO_0040001
subclass of: GO_0051294
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle

polarisome
IAO_0000115: Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.
has OBO namespace: cellular_component
id: GO:0000133
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044448
subclass of: Restriction
  on property: part_of
  some values from: GO_0030427

septin checkpoint
IAO_0000115: A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed.
has OBO namespace: biological_process
id: GO:0000135
type: Class
subclass of: GO_0031565

alpha-1,6-mannosyltransferase complex
IAO_0000115: A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.
has OBO namespace: cellular_component
id: GO:0000136
type: Class
subclass of: GO_0030173
subclass of: GO_0031501
subclass of: Restriction
  on property: part_of
  some values from: Golgi cis cisterna

Golgi cis cisterna
IAO_0000115: The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
has OBO namespace: cellular_component
id: GO:0000137
type: Class
subclass of: GO_0031985

Golgi trans cisterna
IAO_0000115: The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
has OBO namespace: cellular_component
has related synonym: late Golgi
id: GO:0000138
type: Class
subclass of: GO_0031985

Golgi membrane
IAO_0000115: The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
has OBO namespace: cellular_component
id: GO:0000139
type: Class
subclass of: GO_0031090
subclass of: GO_0044431
subclass of: Restriction
  on property: part_of
  some values from: GO_0012505

acylglycerone-phosphate reductase activity
IAO_0000115: Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+).
has db xref: EC:1.1.1.101
has db xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN
has db xref: RHEA:17344
has db xref: Reactome:REACT_759
has exact synonym: 1-acyldihydroxyacetone-phosphate reductase activity
has exact synonym: 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity
has exact synonym: acyldihydroxyacetone phosphate reductase activity
has exact synonym: palmitoyl dihydroxyacetone phosphate reductase activity
has exact synonym: palmitoyl-dihydroxyacetone-phosphate reductase activity
has exact synonym: palmitoyldihydroxyacetone-phosphate reductase activity
has OBO namespace: molecular_function
id: GO:0000140
type: Class
subclass of: GO_0016616

cellular bud neck contractile ring
IAO_0000115: A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: neck ring
has OBO namespace: cellular_component
id: GO:0000142
type: Class
subclass of: GO_0005826
subclass of: Restriction
  on property: part_of
  some values from: GO_0005935

cellular bud neck septin ring
IAO_0000115: A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.
has OBO namespace: cellular_component
id: GO:0000144
type: Class
subclass of: cellular bud neck septin structure
subclass of: GO_0005940
subclass of: GO_0032161
subclass of: Restriction
  on property: part_of
  some values from: GO_0005935

exocyst
IAO_0000115: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
has db xref: Wikipedia:Exocyst
has exact synonym: Sec6/8 complex
has OBO namespace: cellular_component
id: GO:0000145
type: Class
subclass of: GO_0043234
subclass of: GO_0044448

microfilament motor activity
IAO_0000115: Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
has db xref: Reactome:REACT_15541
has db xref: Reactome:REACT_20539
has exact synonym: actin filament motor activity
has exact synonym: actin-filament motor activity
has narrow synonym: muscle motor activity
has OBO namespace: molecular_function
has related synonym: myosin ATPase activity
id: GO:0000146
type: Class
subclass of: motor activity

actin cortical patch assembly
IAO_0000115: Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.
has OBO namespace: biological_process
id: GO:0000147
type: Class
subclass of: GO_0022607
subclass of: GO_0030866

1,3-beta-D-glucan synthase complex
IAO_0000115: A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
has exact synonym: (1->3)-beta-glucan synthase complex
has exact synonym: 1,3-beta-glucan synthase complex
has OBO namespace: cellular_component
id: GO:0000148
type: Class
subclass of: GO_0043234
subclass of: GO_0044459

SNARE binding
IAO_0000115: Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
has db xref: Reactome:REACT_100180
has db xref: Reactome:REACT_101078
has db xref: Reactome:REACT_103740
has db xref: Reactome:REACT_105540
has db xref: Reactome:REACT_106347
has db xref: Reactome:REACT_107235
has db xref: Reactome:REACT_107965
has db xref: Reactome:REACT_109894
has db xref: Reactome:REACT_110250
has db xref: Reactome:REACT_110371
has db xref: Reactome:REACT_110396
has db xref: Reactome:REACT_112169
has db xref: Reactome:REACT_112728
has db xref: Reactome:REACT_113606
has db xref: Reactome:REACT_113753
has db xref: Reactome:REACT_114225
has db xref: Reactome:REACT_114547
has db xref: Reactome:REACT_115054
has db xref: Reactome:REACT_115130
has db xref: Reactome:REACT_115353
has db xref: Reactome:REACT_12411
has db xref: Reactome:REACT_12617
has db xref: Reactome:REACT_14778
has db xref: Reactome:REACT_14821
has db xref: Reactome:REACT_14822
has db xref: Reactome:REACT_15326
has db xref: Reactome:REACT_15338
has db xref: Reactome:REACT_15404
has db xref: Reactome:REACT_15411
has db xref: Reactome:REACT_15448
has db xref: Reactome:REACT_15483
has db xref: Reactome:REACT_15503
has db xref: Reactome:REACT_15517
has db xref: Reactome:REACT_15533
has db xref: Reactome:REACT_15541
has db xref: Reactome:REACT_23813
has db xref: Reactome:REACT_23973
has db xref: Reactome:REACT_29535
has db xref: Reactome:REACT_31215
has db xref: Reactome:REACT_31588
has db xref: Reactome:REACT_34035
has db xref: Reactome:REACT_77361
has db xref: Reactome:REACT_77506
has db xref: Reactome:REACT_77785
has db xref: Reactome:REACT_77831
has db xref: Reactome:REACT_79299
has db xref: Reactome:REACT_80371
has db xref: Reactome:REACT_82023
has db xref: Reactome:REACT_82703
has db xref: Reactome:REACT_83226
has db xref: Reactome:REACT_84308
has db xref: Reactome:REACT_84628
has db xref: Reactome:REACT_87193
has db xref: Reactome:REACT_87411
has db xref: Reactome:REACT_87768
has db xref: Reactome:REACT_90536
has db xref: Reactome:REACT_92466
has db xref: Reactome:REACT_93575
has db xref: Reactome:REACT_93655
has db xref: Reactome:REACT_93705
has db xref: Reactome:REACT_94126
has db xref: Reactome:REACT_94434
has db xref: Reactome:REACT_95323
has db xref: Reactome:REACT_96543
has db xref: Reactome:REACT_96609
has db xref: Reactome:REACT_96753
has db xref: Reactome:REACT_96842
has db xref: Reactome:REACT_97101
has db xref: Reactome:REACT_98480
has db xref: Reactome:REACT_98819
has db xref: Reactome:REACT_99501
has exact synonym: SNAP receptor binding
has OBO namespace: molecular_function
id: GO:0000149
type: Class
subclass of: GO_0005515

recombinase activity
IAO_0000115: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
has db xref: Reactome:REACT_27300
has narrow synonym: strand transferase
has OBO namespace: molecular_function
id: GO:0000150
in subset: gosubset prok
type: Class
comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'.
subclass of: catalytic activity

ubiquitin ligase complex
IAO_0000115: A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex.
has OBO namespace: cellular_component
id: GO:0000151
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0043234
subclass of: GO_0044424

nuclear ubiquitin ligase complex
IAO_0000115: A ubiquitin ligase complex found in the nucleus.
has OBO namespace: cellular_component
id: GO:0000152
type: Class
subclass of: ubiquitin ligase complex
subclass of: GO_0044428
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

cytoplasmic ubiquitin ligase complex
IAO_0000115: A ubiquitin ligase complex found in the cytoplasm.
has OBO namespace: cellular_component
id: GO:0000153
type: Class
subclass of: ubiquitin ligase complex
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737

rRNA modification
IAO_0000115: The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
has alternative id: GO:0016548
has narrow synonym: rRNA editing
has OBO namespace: biological_process
id: GO:0000154
in subset: gosubset prok
type: Class
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subclass of: GO_0006364
subclass of: GO_0009451

phosphorelay sensor kinase activity
IAO_0000115: Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
has db xref: EC:2.7.3.-
has narrow synonym: two-component sensor activity
has narrow synonym: two-component sensor molecule
has narrow synonym: two-component system sensor activity
has OBO namespace: molecular_function
id: GO:0000155
in subset: gosubset prok
type: Class
subclass of: GO_0004673
subclass of: GO_0038023

phosphorelay response regulator activity
IAO_0000115: Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
has narrow synonym: two-component response regulator activity
has OBO namespace: molecular_function
id: GO:0000156
in subset: goslim metagenomics
in subset: gosubset prok
type: Class
subclass of: GO_0004871

protein phosphatase type 2A complex
IAO_0000115: A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
has OBO namespace: cellular_component
id: GO:0000159
type: Class
subclass of: GO_0008287
subclass of: GO_0044424

phosphorelay signal transduction system
IAO_0000115: A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
has exact synonym: histidyl-aspartyl phosphorelay
has narrow synonym: phosphorelay signal transduction system
has OBO namespace: biological_process
id: GO:0000160
in subset: goslim metagenomics
in subset: gosubset prok
type: Class
subclass of: GO_0007165

MAPK cascade involved in osmosensory signaling pathway
IAO_0000115: A MAPK cascade involved in signal transduction in response to change in osmotic conditions.
has exact synonym: MAPKKK cascade during osmolarity sensing
has exact synonym: MAPKKK cascade involved in osmosensory signaling pathway
has exact synonym: MAPKKK cascade involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, MAPKKK cascade
has narrow synonym: High Osmolarity Glycerol (HOG) MAPK pathway
has narrow synonym: Hog1 MAPK pathway
has OBO namespace: biological_process
id: GO:0000161
type: Class
subclass of: MAPK cascade
subclass of: Restriction
  on property: part_of
  some values from: GO_0007231

tryptophan biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
has alternative id: GO:0009096
has db xref: MetaCyc:TRPSYN-PWY
has exact synonym: aromatic amino acid family biosynthetic process, anthranilate pathway
has exact synonym: tryptophan anabolism
has exact synonym: tryptophan biosynthesis
has exact synonym: tryptophan formation
has exact synonym: tryptophan synthesis
has OBO namespace: biological_process
id: GO:0000162
in subset: gosubset prok
type: Class
subclass of: GO_0006568
subclass of: GO_0009073
subclass of: GO_0046219
subclass of: GO_1901607

protein phosphatase type 1 complex
IAO_0000115: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
has OBO namespace: cellular_component
id: GO:0000164
type: Class
subclass of: GO_0008287
subclass of: GO_0044444

MAPK cascade
IAO_0000115: An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
has db xref: Reactome:REACT_101634
has db xref: Reactome:REACT_107261
has db xref: Reactome:REACT_107863
has db xref: Reactome:REACT_108330
has db xref: Reactome:REACT_112235
has db xref: Reactome:REACT_112942
has db xref: Reactome:REACT_113285
has db xref: Reactome:REACT_634
has db xref: Reactome:REACT_79658
has db xref: Reactome:REACT_85806
has db xref: Reactome:REACT_87028
has db xref: Reactome:REACT_87232
has db xref: Reactome:REACT_87855
has db xref: Reactome:REACT_92078
has db xref: Reactome:REACT_92987
has db xref: Reactome:REACT_94585
has db xref: Reactome:REACT_94805
has db xref: Wikipedia:MAPK_cascade
has db xref: Wikipedia:Mitogen-activated_protein_kinase
has exact synonym: MAP kinase cascade
has exact synonym: MAP kinase kinase kinase cascade
has exact synonym: MAPKKK cascade
has exact synonym: mitogen-activated protein kinase cascade
has narrow synonym: ERK/MAPK cascade
has narrow synonym: MAPKKK cascade during sporulation
has OBO namespace: biological_process
has related synonym: MAPK signaling
has related synonym: MAPK signalling
id: GO:0000165
type: Class
comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
subclass of: GO_0007243

nucleotide binding
IAO_0000115: Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
has OBO namespace: molecular_function
id: GO:0000166
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: gosubset prok
type: Class
subclass of: GO_0036094
subclass of: GO_1901265

activation of MAPKKK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing.
has exact synonym: activation of MAP kinase kinase kinase activity during osmolarity sensing
has exact synonym: activation of MAPKKK activity during osmolarity sensing
has exact synonym: activation of MAPKKK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, activation of MAP kinase kinase kinase activity
has exact synonym: osmolarity sensing, activation of MAPKKK activity
has OBO namespace: biological_process
id: GO:0000167
type: Class
subclass of: activation of MAPKKK activity
subclass of: GO_0047484
subclass of: GO_0080135

activation of MAPKK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing.
has alternative id: GO:0007233
has exact synonym: activation of MAP kinase kinase activity during osmolarity sensing
has exact synonym: activation of MAPKK activity during osmolarity sensing
has exact synonym: activation of MAPKK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, activation of MAP kinase kinase activity
has exact synonym: osmolarity sensing, activation of MAPKK activity
has narrow synonym: activation of Pbs2 kinase
has OBO namespace: biological_process
id: GO:0000168
type: Class
subclass of: activation of MAPKK activity
subclass of: GO_0047484
subclass of: GO_0080135

activation of MAPK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing.
has exact synonym: activation of MAPK activity during osmolarity sensing
has exact synonym: activation of MAPK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, activation of MAPK activity
has OBO namespace: biological_process
id: GO:0000169
type: Class
subclass of: activation of MAPK activity
subclass of: GO_0047484
subclass of: GO_0080135

sphingosine hydroxylase activity
IAO_0000115: Catalysis of the hydroxylation of sphingolipid long chain bases.
has db xref: Reactome:REACT_100351
has db xref: Reactome:REACT_103503
has db xref: Reactome:REACT_104963
has db xref: Reactome:REACT_115687
has db xref: Reactome:REACT_19258
has db xref: Reactome:REACT_29940
has db xref: Reactome:REACT_31871
has db xref: Reactome:REACT_80095
has db xref: Reactome:REACT_82371
has db xref: Reactome:REACT_85471
has db xref: Reactome:REACT_85651
has db xref: Reactome:REACT_86222
has db xref: Reactome:REACT_91283
has db xref: Reactome:REACT_92284
has db xref: Reactome:REACT_96037
has db xref: Reactome:REACT_97092
has db xref: Reactome:REACT_99475
has OBO namespace: molecular_function
id: GO:0000170
type: Class
subclass of: GO_0016491

ribonuclease MRP activity
IAO_0000115: Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.
has db xref: Wikipedia:RNase_MRP
has exact synonym: RNase MRP
has OBO namespace: molecular_function
id: GO:0000171
type: Class
subclass of: ribonuclease activity

ribonuclease MRP complex
IAO_0000115: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
has exact synonym: RNase MRP complex
has exact synonym: ribonuclease mitochondrial RNA processing complex
has OBO namespace: cellular_component
id: GO:0000172
type: Class
subclass of: GO_0005732

inactivation of MAPK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing.
has exact synonym: inactivation of MAPK activity during osmolarity sensing
has exact synonym: inactivation of MAPK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, inactivation of MAPK
has exact synonym: osmolarity sensing, termination of MAPK activity
has exact synonym: termination of MAPK activity during osmolarity sensing
has OBO namespace: biological_process
id: GO:0000173
type: Class
subclass of: inactivation of MAPK activity
subclass of: GO_0009968
subclass of: GO_0047484
subclass of: GO_0080135
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0007231

inactivation of MAPK (mating sensu Saccharomyces)
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.
IAO_0100001: GO:0000750
has OBO namespace: biological_process
id: GO:0000174
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

3'-5'-exoribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
has db xref: EC:3.1.13.-
has db xref: Reactome:REACT_102966
has db xref: Reactome:REACT_108214
has db xref: Reactome:REACT_20588
has db xref: Reactome:REACT_33991
has db xref: Reactome:REACT_34078
has db xref: Reactome:REACT_78363
has db xref: Reactome:REACT_82118
has db xref: Reactome:REACT_88115
has db xref: Reactome:REACT_89880
has db xref: Reactome:REACT_92153
has db xref: Reactome:REACT_93499
has db xref: Reactome:REACT_95913
has db xref: Reactome:REACT_95921
has db xref: Reactome:REACT_96267
has db xref: Reactome:REACT_99422
has exact synonym: 3'-5' exoribonuclease activity
has OBO namespace: molecular_function
id: GO:0000175
in subset: gosubset prok
type: Class
subclass of: GO_0008408
subclass of: GO_0016896

nuclear exosome (RNase complex)
IAO_0000115: Complex of 3'-5' exoribonucleases found in the nucleus.
has exact synonym: eukaryotic exosome multienzyme ribonuclease complex
has exact synonym: nuclear exosome (ribonuclease complex)
has exact synonym: nuclear exosome multienzyme ribonuclease complex
has OBO namespace: cellular_component
id: GO:0000176
type: Class
subclass of: exosome (RNase complex)
subclass of: GO_0044428
subclass of: Restriction
  on property: part_of
  some values from: GO_0031981
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

cytoplasmic exosome (RNase complex)
IAO_0000115: Complex of 3'-5' exoribonucleases found in the cytoplasm.
has exact synonym: cytoplasmic exosome (ribonuclease complex)
has exact synonym: cytoplasmic exosome multienzyme ribonuclease complex
has exact synonym: prokaryotic exosome multienzyme ribonuclease complex
has OBO namespace: cellular_component
id: GO:0000177
type: Class
subclass of: exosome (RNase complex)
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737

exosome (RNase complex)
IAO_0000115: Complex of 3'-5' exoribonucleases.
has exact synonym: exosome (ribonucleasease complex)
has exact synonym: exosome multienzyme ribonuclease complex
has OBO namespace: cellular_component
id: GO:0000178
in subset: goslim pir
type: Class
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
subclass of: GO_0043234
subclass of: GO_0044424

rRNA (adenine-N6,N6-)-dimethyltransferase activity
IAO_0000115: Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
has alternative id: GO:0043790
has db xref: EC:2.1.1.-
has exact synonym: 18S rRNA dimethylase activity
has exact synonym: S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity
has exact synonym: dimethyladenosine transferase activity
has OBO namespace: molecular_function
id: GO:0000179
in subset: gosubset prok
type: Class
subclass of: GO_0008170
subclass of: GO_0016433

cytosolic large ribosomal subunit
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0022625
has OBO namespace: cellular_component
id: GO:0000180
type: Class
comment: This term was made obsolete because more specific children exist.
deprecated: true

cytosolic small ribosomal subunit
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0022627
has OBO namespace: cellular_component
id: GO:0000181
type: Class
comment: This term was made obsolete because more specific children exist.
deprecated: true

rDNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.
has exact synonym: ribosomal DNA binding
has OBO namespace: molecular_function
id: GO:0000182
type: Class
subclass of: GO_0043565

chromatin silencing at rDNA
IAO_0000115: Repression of transcription of ribosomal DNA by altering the structure of chromatin.
has exact synonym: chromatin silencing at ribosomal DNA
has exact synonym: heterochromatic silencing at rDNA
has exact synonym: rDNA chromatin silencing
has OBO namespace: biological_process
id: GO:0000183
type: Class
subclass of: GO_0006342

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
IAO_0000115: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
has db xref: Reactome:REACT_75886
has db xref: Wikipedia:Nonsense-mediated_decay
has db xref: Wikipedia:Nonsense-mediated_mRNA_decay
has exact synonym: mRNA breakdown, nonsense-mediated decay
has exact synonym: mRNA catabolic process, nonsense-mediated
has exact synonym: mRNA catabolism, nonsense-mediated
has exact synonym: mRNA degradation, nonsense-mediated decay
has exact synonym: nonsense-mediated mRNA decay
has exact synonym: nuclear mRNA catabolic process, nonsense-mediated decay
has OBO namespace: biological_process
id: GO:0000184
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

activation of MAPKKK activity
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase.
has broad synonym: positive regulation of MAP kinase kinase kinase activity
has broad synonym: positive regulation of MAPKKK activity
has exact synonym: activation of MAP kinase kinase kinase
has exact synonym: activation of MAP3K activity
has narrow synonym: activation of MAPKKK activity during sporulation
has OBO namespace: biological_process
id: GO:0000185
type: Class
subclass of: GO_0032147
subclass of: GO_0043408
subclass of: GO_0071902

activation of MAPKK activity
IAO_0000115: The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK.
has alternative id: GO:0007255
has broad synonym: positive regulation of MAPKK activity
has db xref: Reactome:REACT_101798
has db xref: Reactome:REACT_102728
has db xref: Reactome:REACT_103900
has db xref: Reactome:REACT_104177
has db xref: Reactome:REACT_104271
has db xref: Reactome:REACT_110634
has db xref: Reactome:REACT_113771
has db xref: Reactome:REACT_114228
has db xref: Reactome:REACT_114817
has db xref: Reactome:REACT_12005
has db xref: Reactome:REACT_33773
has db xref: Reactome:REACT_81505
has db xref: Reactome:REACT_81553
has db xref: Reactome:REACT_82861
has db xref: Reactome:REACT_86719
has db xref: Reactome:REACT_86891
has db xref: Reactome:REACT_87045
has db xref: Reactome:REACT_89175
has db xref: Reactome:REACT_89555
has db xref: Reactome:REACT_91625
has db xref: Reactome:REACT_94138
has db xref: Reactome:REACT_94626
has db xref: Reactome:REACT_95763
has db xref: Reactome:REACT_962
has db xref: Reactome:REACT_97271
has db xref: Reactome:REACT_98727
has exact synonym: activation of MAP kinase kinase activity
has exact synonym: activation of MAP/ERK kinase kinase
has exact synonym: activation of MAP2K activity
has narrow synonym: activation of MAPKK activity during sporulation
has OBO namespace: biological_process
id: GO:0000186
type: Class
subclass of: GO_0006468
subclass of: GO_0032147
subclass of: GO_0043408

activation of MAPK activity
IAO_0000115: The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.
has db xref: Reactome:REACT_100881
has db xref: Reactome:REACT_101870
has db xref: Reactome:REACT_101978
has db xref: Reactome:REACT_102664
has db xref: Reactome:REACT_102813
has db xref: Reactome:REACT_103235
has db xref: Reactome:REACT_103251
has db xref: Reactome:REACT_106101
has db xref: Reactome:REACT_112664
has db xref: Reactome:REACT_113767
has db xref: Reactome:REACT_114778
has db xref: Reactome:REACT_1482
has db xref: Reactome:REACT_21399
has db xref: Reactome:REACT_25355
has db xref: Reactome:REACT_25370
has db xref: Reactome:REACT_28684
has db xref: Reactome:REACT_29727
has db xref: Reactome:REACT_30502
has db xref: Reactome:REACT_32301
has db xref: Reactome:REACT_34590
has db xref: Reactome:REACT_77440
has db xref: Reactome:REACT_77987
has db xref: Reactome:REACT_78017
has db xref: Reactome:REACT_83894
has db xref: Reactome:REACT_84937
has db xref: Reactome:REACT_86273
has db xref: Reactome:REACT_86655
has db xref: Reactome:REACT_87442
has db xref: Reactome:REACT_88492
has db xref: Reactome:REACT_88606
has db xref: Reactome:REACT_91962
has db xref: Reactome:REACT_93371
has db xref: Reactome:REACT_98123
has db xref: Reactome:REACT_99633
has exact synonym: MAPK activation
has exact synonym: activation of MAP kinase
has narrow synonym: activation of MAPK activity during sporulation
has OBO namespace: biological_process
id: GO:0000187
type: Class
subclass of: GO_0006468
subclass of: GO_0032147
subclass of: GO_0043406

inactivation of MAPK activity
IAO_0000115: Any process that terminates the activity of the active enzyme MAP kinase.
has exact synonym: termination of MAPK activity
has narrow synonym: inactivation of MAPK during sporulation
has OBO namespace: biological_process
id: GO:0000188
type: Class
subclass of: GO_0043407

MAPK import into nucleus
IAO_0000115: The directed movement of a MAP kinase to the nucleus upon activation.
has db xref: Reactome:REACT_103042
has db xref: Reactome:REACT_105886
has db xref: Reactome:REACT_106064
has db xref: Reactome:REACT_107045
has db xref: Reactome:REACT_110766
has db xref: Reactome:REACT_113196
has db xref: Reactome:REACT_114932
has db xref: Reactome:REACT_115101
has db xref: Reactome:REACT_1866
has db xref: Reactome:REACT_29004
has db xref: Reactome:REACT_32259
has db xref: Reactome:REACT_33595
has db xref: Reactome:REACT_487
has db xref: Reactome:REACT_510
has db xref: Reactome:REACT_78269
has db xref: Reactome:REACT_79422
has db xref: Reactome:REACT_81446
has db xref: Reactome:REACT_87335
has db xref: Reactome:REACT_89933
has db xref: Reactome:REACT_94910
has db xref: Reactome:REACT_95119
has db xref: Reactome:REACT_97762
has narrow synonym: nuclear translocation of MAPK
has OBO namespace: biological_process
id: GO:0000189
type: Class
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
subclass of: GO_0006606
subclass of: Restriction
  on property: part_of
  some values from: MAPK cascade

MAPKKK cascade (pseudohyphal growth)
IAO_0000115: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth.
has OBO namespace: biological_process
id: GO:0000190
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

activation of MAPKKK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth.
has OBO namespace: biological_process
id: GO:0000191
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

activation of MAPKK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth.
has OBO namespace: biological_process
id: GO:0000192
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

activation of MAPK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.
has OBO namespace: biological_process
id: GO:0000193
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

inactivation of MAPK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.
has OBO namespace: biological_process
id: GO:0000194
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

nuclear translocation of MAPK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth.
has OBO namespace: biological_process
id: GO:0000195
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

MAPK cascade involved in cell wall biogenesis
IAO_0000115: A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: MAPKKK cascade involved in cell wall biogenesis
has exact synonym: cell wall biogenesis, MAPKKK cascade
has narrow synonym: Mpk1 cascade
has narrow synonym: Slt2 cascade
has OBO namespace: biological_process
id: GO:0000196
type: Class
subclass of: MAPK cascade
subclass of: Restriction
  on property: part_of
  some values from: GO_0042546

activation of MAPKKK activity involved in cell wall biogenesis
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: activation of MAP kinase kinase kinase activity during cell wall biogenesis
has exact synonym: activation of MAPKKK activity involved in cell wall integrity
has exact synonym: cell wall biogenesis, activation of MAP kinase kinase kinase activity
has exact synonym: cell wall biogenesis, activation of MAPKKK activity
has OBO namespace: biological_process
id: GO:0000197
type: Class
subclass of: activation of MAPKKK activity
subclass of: GO_0044087

activation of MAPKK activity involved in cell wall biogenesis
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: activation of MAP kinase kinase activity during cell wall biogenesis
has exact synonym: activation of MAPKK activity involved in cell wall integrity
has exact synonym: cell wall biogenesis, activation of MAP kinase kinase activity
has exact synonym: cell wall biogenesis, activation of MAPKK activity
has OBO namespace: biological_process
id: GO:0000198
type: Class
subclass of: activation of MAPKK activity
subclass of: GO_0044087

activation of MAPK activity involved in cell wall biogenesis
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: activation of MAPK activity involved in cell wall integrity
has exact synonym: cell wall biogenesis, activation of MAPK activity
has OBO namespace: biological_process
id: GO:0000199
type: Class
subclass of: activation of MAPK activity
subclass of: GO_0044087

inactivation of MAPK activity involved in cell wall biogenesis
IAO_0000115: Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: cell wall biogenesis, inactivation of MAPK activity
has exact synonym: cell wall biogenesis, termination of MAPK activity
has exact synonym: inactivation of MAPK activity involved in cell wall integrity
has exact synonym: termination of MAPK activity during cell wall biogenesis
has OBO namespace: biological_process
id: GO:0000200
type: Class
subclass of: inactivation of MAPK activity
subclass of: GO_0044087

MAPK import into nucleus involved in cell wall biogenesis
IAO_0000115: The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: MAPK import into nucleus involved in cell wall integrity
has exact synonym: cell wall biogenesis, MAPK import into nucleus
has narrow synonym: cell wall biogenesis, nuclear translocation of MAPK
has narrow synonym: nuclear translocation of MAPK involved in cell wall biogenesis
has narrow synonym: nuclear translocation of MAPK involved in cell wall integrity
has OBO namespace: biological_process
id: GO:0000201
type: Class
subclass of: MAPK import into nucleus
subclass of: Restriction
  on property: part_of
  some values from: GO_0042546
subclass of: Restriction
  on property: part_of
  some values from: MAPK cascade involved in cell wall biogenesis

MAPKKK cascade during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
has OBO namespace: biological_process
id: GO:0000202
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

activation of MAPKKK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
has OBO namespace: biological_process
id: GO:0000203
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

activation of MAPKK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
has OBO namespace: biological_process
id: GO:0000204
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

activation of MAPK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
has OBO namespace: biological_process
id: GO:0000205
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

inactivation of MAPK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
has OBO namespace: biological_process
id: GO:0000206
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
has OBO namespace: biological_process
id: GO:0000207
type: Class
comment: This term was made obsolete because it is a gene product specific term.
deprecated: true

MAPK import into nucleus involved in osmosensory signaling pathway
IAO_0000115: The directed movement of a MAP kinase to the nucleus during osmolarity sensing.
has exact synonym: MAPK import into nucleus during osmolarity sensing
has exact synonym: MAPK import into nucleus involved in osmosensory signalling pathway
has exact synonym: nuclear translocation of MAPK during osmolarity sensing
has exact synonym: osmolarity sensing, MAPK import into nucleus
has narrow synonym: nuclear translocation of MAPK involved in osmosensory signaling pathway
has narrow synonym: nuclear translocation of MAPK involved in osmosensory signalling pathway
has narrow synonym: osmolarity sensing, nuclear translocation of MAPK
has OBO namespace: biological_process
id: GO:0000208
type: Class
subclass of: MAPK import into nucleus
subclass of: Restriction
  on property: part_of
  some values from: GO_0007231
subclass of: Restriction
  on property: part_of
  some values from: MAPK cascade involved in osmosensory signaling pathway

protein polyubiquitination
IAO_0000115: Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
has db xref: Reactome:REACT_75842
has exact synonym: protein polyubiquitinylation
has exact synonym: protein polyubiquitylation
has OBO namespace: biological_process
has related synonym: polyubiquitin
id: GO:0000209
type: Class
subclass of: GO_0016567

NAD+ diphosphatase activity
IAO_0000115: Catalysis of the reaction: NAD+ + H2O = AMP + NMN.
has broad synonym: NADH pyrophosphatase activity
has broad synonym: NADP pyrophosphatase activity
has db xref: EC:3.6.1.22
has db xref: MetaCyc:NADPYROPHOSPHAT-RXN
has db xref: RHEA:11803
has exact synonym: NAD diphosphatase activity
has exact synonym: NAD pyrophosphatase activity
has exact synonym: NAD(+) pyrophosphatase activity
has exact synonym: NAD+ phosphohydrolase activity
has exact synonym: NAD+ pyrophosphatase activity
has exact synonym: nicotinamide adenine dinucleotide pyrophosphatase activity
has OBO namespace: molecular_function
id: GO:0000210
in subset: gosubset prok
type: Class
subclass of: nucleotide diphosphatase activity

protein degradation tagging activity
IAO_0000115: OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction.
consider: GO:0005515
consider: GO:0019941
consider: GO:0042787
has OBO namespace: molecular_function
id: GO:0000211
type: Class
comment: This term was made obsolete because it represents a biological process and a molecular function.
deprecated: true

meiotic spindle organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
has exact synonym: meiotic spindle organisation
has exact synonym: spindle organization during meiosis
has OBO namespace: biological_process
has related synonym: meiotic spindle organization and biogenesis
id: GO:0000212
type: Class
subclass of: GO_0007051
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321

tRNA-intron endonuclease activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
has db xref: EC:3.1.27.9
has db xref: MetaCyc:3.1.27.9-RXN
has exact synonym: splicing endonuclease activity
has exact synonym: tRNA splicing endonuclease activity
has exact synonym: tRNA-intron endoribonuclease activity
has exact synonym: tRNA-splicing endonuclease activity
has exact synonym: tRNATRPintron endonuclease activity
has exact synonym: transfer ribonucleate intron endoribonuclease activity
has exact synonym: transfer splicing endonuclease activity
has OBO namespace: molecular_function
id: GO:0000213
type: Class
subclass of: tRNA-specific ribonuclease activity
subclass of: GO_0016892

tRNA-intron endonuclease complex
IAO_0000115: A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
has exact synonym: SEN complex
has exact synonym: tRNA splicing endonuclease complex
has OBO namespace: cellular_component
id: GO:0000214
type: Class
subclass of: GO_0043234
subclass of: GO_0044428

tRNA 2'-phosphotransferase activity
IAO_0000115: Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.
has db xref: EC:2.7.1.160
has db xref: MetaCyc:2.7.1.160-RXN
has exact synonym: 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity
has exact synonym: 2'-phospho-tRNA:NAD+ phosphotransferase activity
has narrow synonym: yeast 2'-phosphotransferase activity
has OBO namespace: molecular_function
has related synonym: Tpt1
has related synonym: Tpt1p
id: GO:0000215
type: Class
subclass of: GO_0008665
subclass of: GO_0016773

M/G1 transition of mitotic cell cycle
IAO_0000115: Progression from M phase to G1 phase of the mitotic cell cycle.
has db xref: Reactome:REACT_103126
has db xref: Reactome:REACT_103368
has db xref: Reactome:REACT_105126
has db xref: Reactome:REACT_108209
has db xref: Reactome:REACT_108301
has db xref: Reactome:REACT_109437
has db xref: Reactome:REACT_110954
has db xref: Reactome:REACT_1725
has db xref: Reactome:REACT_32146
has db xref: Reactome:REACT_32196
has db xref: Reactome:REACT_77227
has db xref: Reactome:REACT_77394
has db xref: Reactome:REACT_78459
has db xref: Reactome:REACT_79481
has db xref: Reactome:REACT_83776
has db xref: Reactome:REACT_86397
has db xref: Reactome:REACT_89032
has db xref: Reactome:REACT_94915
has OBO namespace: biological_process
id: GO:0000216
type: Class
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

DNA secondary structure binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions.
has OBO namespace: molecular_function
id: GO:0000217
type: Class
subclass of: GO_0043566

vacuolar hydrogen-transporting ATPase
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0016469
has exact synonym: V-ATPase
has OBO namespace: cellular_component
id: GO:0000219
type: Class
comment: This term was made obsolete because more specific terms were created.
deprecated: true

vacuolar proton-transporting V-type ATPase, V0 domain
IAO_0000115: The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
has exact synonym: vacuolar hydrogen ion-transporting ATPase V0 domain
has OBO namespace: cellular_component
id: GO:0000220
type: Class
comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
subclass of: GO_0033179
subclass of: GO_0044437
subclass of: Restriction
  on property: part_of
  some values from: GO_0016471
subclass of: Restriction
  on property: part_of
  some values from: GO_0005773

vacuolar proton-transporting V-type ATPase, V1 domain
IAO_0000115: The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
has exact synonym: vacuolar hydrogen ion-transporting ATPase V1 domain
has OBO namespace: cellular_component
id: GO:0000221
type: Class
comment: Note that this domain generally consists of eight subunits.
subclass of: GO_0033180
subclass of: GO_0044437
subclass of: Restriction
  on property: part_of
  some values from: GO_0016471
subclass of: Restriction
  on property: part_of
  some values from: GO_0005773

plasma membrane proton-transporting V-type ATPase, V0 domain
IAO_0000115: The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.
has exact synonym: plasma membrane hydrogen ion-transporting ATPase V0 domain
has OBO namespace: cellular_component
id: GO:0000222
type: Class
subclass of: GO_0033179
subclass of: GO_0044459
subclass of: Restriction
  on property: part_of
  some values from: GO_0005886
subclass of: Restriction
  on property: part_of
  some values from: GO_0005887
subclass of: Restriction
  on property: part_of
  some values from: GO_0033181

plasma membrane proton-transporting V-type ATPase, V1 domain
IAO_0000115: The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.
has exact synonym: plasma membrane hydrogen ion-transporting ATPase V1 domain
has OBO namespace: cellular_component
id: GO:0000223
type: Class
subclass of: GO_0033180
subclass of: GO_0044459
subclass of: Restriction
  on property: part_of
  some values from: GO_0005886
subclass of: Restriction
  on property: part_of
  some values from: GO_0033181
subclass of: Restriction
  on property: part_of
  some values from: GO_0005887

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
IAO_0000115: Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.
has broad synonym: glycopeptidase activity
has broad synonym: glycopeptide N-glycosidase activity
has db xref: EC:3.5.1.52
has db xref: MetaCyc:3.5.1.52-RXN
has exact synonym: N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity
has exact synonym: PNGase
has narrow synonym: jack-bean glycopeptidase
has OBO namespace: molecular_function
has related synonym: N-glycanase activity
has related synonym: N-oligosaccharide glycopeptidase activity
has related synonym: PNGase A
has related synonym: PNGase F
has related synonym: peptide:N-glycanase
id: GO:0000224
in subset: gosubset prok
type: Class
subclass of: GO_0016811

N-acetylglucosaminylphosphatidylinositol deacetylase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane.
has db xref: EC:3.5.1.89
has db xref: MetaCyc:3.1.1.69-RXN
has db xref: RHEA:11663
has db xref: Reactome:REACT_100003
has db xref: Reactome:REACT_103061
has db xref: Reactome:REACT_107021
has db xref: Reactome:REACT_111009
has db xref: Reactome:REACT_114989
has db xref: Reactome:REACT_29732
has db xref: Reactome:REACT_32276
has db xref: Reactome:REACT_33502
has db xref: Reactome:REACT_33809
has db xref: Reactome:REACT_77843
has db xref: Reactome:REACT_779
has db xref: Reactome:REACT_82306
has db xref: Reactome:REACT_82765
has db xref: Reactome:REACT_88022
has db xref: Reactome:REACT_88604
has db xref: Reactome:REACT_91074
has db xref: Reactome:REACT_98776
has exact synonym: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity
has exact synonym: GlcNAc-PI de-N-acetylase activity
has exact synonym: GlcNAc-PI deacetylase activity
has exact synonym: N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity
has exact synonym: N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity
has exact synonym: acetylglucosaminylphosphatidylinositol deacetylase activity
has OBO namespace: molecular_function
id: GO:0000225
type: Class
comment: Note that this function was formerly EC:3.1.1.69.
subclass of: GO_0016811
subclass of: GO_0019213

microtubule cytoskeleton organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
has exact synonym: microtubule cytoskeleton organisation
has exact synonym: microtubule dynamics
has OBO namespace: biological_process
has related synonym: microtubule cytoskeleton organization and biogenesis
id: GO:0000226
type: Class
subclass of: GO_0007010
subclass of: GO_0007017

oxaloacetate secondary active transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
has OBO namespace: molecular_function
has related synonym: oxaloacetate carrier activity
id: GO:0000227
type: Class
subclass of: GO_0015131
subclass of: GO_0015291

nuclear chromosome
IAO_0000115: A chromosome found in the nucleus of a eukaryotic cell.
has narrow synonym: nuclear interphase chromosome
has OBO namespace: cellular_component
id: GO:0000228
in subset: goslim generic
type: Class
subclass of: GO_0005694
subclass of: GO_0044428
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634
subclass of: Restriction
  on property: part_of
  some values from: GO_0031981

cytoplasmic chromosome
IAO_0000115: A chromosome found in the cytoplasm.
has narrow synonym: cytoplasmic interphase chromosome
has OBO namespace: cellular_component
id: GO:0000229
in subset: goslim generic
in subset: gosubset prok
type: Class
subclass of: GO_0005694
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737

nuclear mitotic chromosome
IAO_0000115: OBSOLETE. A chromosome found in the nucleus during mitosis.
consider: GO:0000794
has OBO namespace: cellular_component
id: GO:0000230
type: Class
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
deprecated: true

cytoplasmic mitotic chromosome
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm during mitosis.
consider: GO:0000793
has OBO namespace: cellular_component
id: GO:0000231
type: Class
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
deprecated: true

nuclear interphase chromosome
IAO_0000115: OBSOLETE. A chromosome found in the nucleus during interphase.
consider: GO:0000228
has OBO namespace: cellular_component
id: GO:0000232
type: Class
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
deprecated: true

cytoplasmic interphase chromosome
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm during interphase.
consider: GO:0000229
has OBO namespace: cellular_component
id: GO:0000233
type: Class
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
deprecated: true

phosphoethanolamine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate.
has db xref: EC:2.1.1.103
has db xref: KEGG:R02037
has db xref: MetaCyc:2.1.1.103-RXN
has db xref: RHEA:20366
has db xref: RHEA:20368
has exact synonym: S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity
has exact synonym: phosphoethanolamine methyltransferase activity
has OBO namespace: molecular_function
id: GO:0000234
type: Class
subclass of: GO_0008170
subclass of: GO_0008757

astral microtubule
IAO_0000115: Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
has OBO namespace: cellular_component
id: GO:0000235
type: Class
subclass of: GO_0005876
subclass of: GO_0005881
subclass of: Restriction
  on property: part_of
  some values from: GO_0005818

mitotic prometaphase
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
has db xref: Reactome:REACT_102823
has db xref: Reactome:REACT_104270
has db xref: Reactome:REACT_105082
has db xref: Reactome:REACT_114704
has db xref: Reactome:REACT_118069
has db xref: Reactome:REACT_118526
has db xref: Reactome:REACT_118539
has db xref: Reactome:REACT_31336
has db xref: Reactome:REACT_31385
has db xref: Reactome:REACT_682
has db xref: Reactome:REACT_79351
has db xref: Reactome:REACT_83126
has db xref: Reactome:REACT_98905
has db xref: Reactome:REACT_99376
has OBO namespace: biological_process
id: GO:0000236
type: Class
subclass of: GO_0022403
subclass of: Restriction
  on property: part_of
  some values from: GO_0007067

leptotene
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through the first stage of prophase I in meiosis, in which chromosomes first become visible.
has db xref: Wikipedia:Leptotene
has db xref: Wikipedia:Meiosis#Leptotene
has OBO namespace: biological_process
id: GO:0000237
type: Class
subclass of: GO_0022403
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007128

zygotene
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.
has db xref: Wikipedia:Meiosis#Zygotene
has db xref: Wikipedia:Zygotene
has OBO namespace: biological_process
id: GO:0000238
type: Class
subclass of: GO_0022403
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007128

pachytene
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.
has db xref: Wikipedia:Meiosis#Pachytene
has db xref: Wikipedia:Pachytene
has OBO namespace: biological_process
id: GO:0000239
type: Class
subclass of: GO_0022403
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007128

diplotene
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.
has db xref: Wikipedia:Diplotene
has db xref: Wikipedia:Meiosis#Diplotene
has OBO namespace: biological_process
id: GO:0000240
type: Class
subclass of: GO_0022403
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007128

diakinesis
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I.
has db xref: Wikipedia:Diakinesis
has db xref: Wikipedia:Meiosis#Diakinesis
has OBO namespace: biological_process
id: GO:0000241
type: Class
subclass of: GO_0022403
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007128

pericentriolar material
IAO_0000115: A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
has OBO namespace: cellular_component
id: GO:0000242
type: Class
subclass of: GO_0044450
subclass of: Restriction
  on property: part_of
  some values from: GO_0005813

commitment complex
IAO_0000115: A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.
has narrow synonym: mammalian spliceosomal E complex
has narrow synonym: mammalian spliceosomal complex E
has narrow synonym: yeast spliceosomal complex CC
has OBO namespace: cellular_component
id: GO:0000243
type: Class
subclass of: GO_0005684

assembly of spliceosomal tri-snRNP
IAO_0000115: The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
has alternative id: GO:0000351
has alternative id: GO:0000355
has broad synonym: snRNP recycling
has exact synonym: spliceosomal tri-snRNP assembly
has narrow synonym: assembly of spliceosomal tri-snRNP U4/U6.U5
has narrow synonym: assembly of spliceosomal tri-snRNP U4atac/U6atac.U5
has narrow synonym: spliceosomal tri-snRNP U4/U6.U5 assembly
has narrow synonym: spliceosomal tri-snRNP U4atac/U6atac.U5 assembly
has OBO namespace: biological_process
id: GO:0000244
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal snRNP assembly

spliceosomal complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
has broad synonym: spliceosome assembly
has OBO namespace: biological_process
id: GO:0000245
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: mRNA splicing, via spliceosome

delta24(24-1) sterol reductase activity
IAO_0000115: Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH.
has db xref: EC:1.3.1.71
has db xref: KEGG:R05641
has db xref: MetaCyc:1.3.1.71-RXN
has db xref: RHEA:18504
has exact synonym: C-24(28) sterol reductase activity
has exact synonym: D24(24-1)-sterol reductase activity
has exact synonym: delta24(241)-sterol reductase activity
has exact synonym: ergosterol:NADP+ delta24(241)-oxidoreductase activity
has exact synonym: sterol Delta(24(28))-methylene reductase activity
has exact synonym: sterol Delta(24(28))-reductase activity
has exact synonym: sterol delta-24(28) methylene reductase activity
has exact synonym: sterol delta-24(28) reductase activity
has exact synonym: sterol delta24(28)-methylene reductase activity
has exact synonym: sterol delta24(28)-reductase activity
has OBO namespace: molecular_function
id: GO:0000246
in subset: gosubset prok
type: Class
subclass of: GO_0016628

C-8 sterol isomerase activity
IAO_0000115: Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.
has db xref: EC:5.3.3.-
has exact synonym: delta-8-delta-7 sterol isomerase activity
has OBO namespace: molecular_function
id: GO:0000247
type: Class
subclass of: GO_0016863

C-5 sterol desaturase activity
IAO_0000115: Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
has db xref: Reactome:REACT_10092
has db xref: Reactome:REACT_106801
has db xref: Reactome:REACT_108498
has db xref: Reactome:REACT_110659
has db xref: Reactome:REACT_34122
has db xref: Reactome:REACT_34697
has db xref: Reactome:REACT_79598
has db xref: Reactome:REACT_84206
has db xref: Reactome:REACT_85577
has db xref: Reactome:REACT_86700
has db xref: Reactome:REACT_98513
has exact synonym: sterol-C5-desaturase activity
has OBO namespace: molecular_function
id: GO:0000248
type: Class
subclass of: GO_0016717
subclass of: GO_0070704

C-22 sterol desaturase activity
IAO_0000115: Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
has OBO namespace: molecular_function
id: GO:0000249
type: Class
subclass of: GO_0016717
subclass of: GO_0070704

lanosterol synthase activity
IAO_0000115: Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
has broad synonym: 2,3-oxidosqualene sterol cyclase activity
has broad synonym: squalene epoxidase-cyclase activity
has db xref: EC:5.4.99.7
has db xref: KEGG:R03199
has db xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN
has db xref: RHEA:14624
has db xref: Reactome:REACT_106250
has db xref: Reactome:REACT_112890
has db xref: Reactome:REACT_114747
has db xref: Reactome:REACT_29522
has db xref: Reactome:REACT_33379
has db xref: Reactome:REACT_78122
has db xref: Reactome:REACT_84749
has db xref: Reactome:REACT_86645
has db xref: Reactome:REACT_88346
has db xref: Reactome:REACT_89548
has db xref: Reactome:REACT_92166
has db xref: Reactome:REACT_93681
has db xref: Reactome:REACT_9391
has db xref: Reactome:REACT_96289
has exact synonym: (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
has exact synonym: 2,3-epoxysqualene lanosterol cyclase activity
has exact synonym: 2,3-epoxysqualene--lanosterol cyclase activity
has exact synonym: 2,3-epoxysqualene-lanosterol cyclase activity
has exact synonym: 2,3-oxidosqualene-lanosterol cyclase activity
has exact synonym: OSC
has exact synonym: lanosterol 2,3-oxidosqualene cyclase activity
has exact synonym: oxidosqualene--lanosterol cyclase activity
has exact synonym: oxidosqualene-lanosterol cyclase activity
has exact synonym: oxidosqualene:lanosterol cyclase activity
has exact synonym: squalene 2,3-epoxide:lanosterol cyclase activity
has exact synonym: squalene-2,3-oxide-lanosterol cyclase activity
has OBO namespace: molecular_function
id: GO:0000250
in subset: gosubset prok
type: Class
subclass of: GO_0031559

C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
IAO_0000115: Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
has db xref: EC:1.1.1.-
has db xref: Reactome:REACT_10053
has db xref: Reactome:REACT_103278
has db xref: Reactome:REACT_103729
has db xref: Reactome:REACT_105643
has db xref: Reactome:REACT_106602
has db xref: Reactome:REACT_107465
has db xref: Reactome:REACT_108692
has db xref: Reactome:REACT_108789
has db xref: Reactome:REACT_109155
has db xref: Reactome:REACT_112688
has db xref: Reactome:REACT_112771
has db xref: Reactome:REACT_112854
has db xref: Reactome:REACT_112960
has db xref: Reactome:REACT_112995
has db xref: Reactome:REACT_113072
has db xref: Reactome:REACT_113373
has db xref: Reactome:REACT_113553
has db xref: Reactome:REACT_114106
has db xref: Reactome:REACT_114356
has db xref: Reactome:REACT_115015
has db xref: Reactome:REACT_115441
has db xref: Reactome:REACT_30127
has db xref: Reactome:REACT_31080
has db xref: Reactome:REACT_32363
has db xref: Reactome:REACT_33091
has db xref: Reactome:REACT_77107
has db xref: Reactome:REACT_82876
has db xref: Reactome:REACT_85383
has db xref: Reactome:REACT_89091
has db xref: Reactome:REACT_91545
has db xref: Reactome:REACT_91980
has db xref: Reactome:REACT_9949
has exact synonym: 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
has OBO namespace: molecular_function
has related synonym: 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
has related synonym: 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
has related synonym: 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
has related synonym: C-3 sterol dehydrogenase (C-4 decarboxylase) activity
has related synonym: C-3 sterol dehydrogenase activity
has related synonym: sterol 4alpha-carboxylic decarboxylase activity
has related synonym: sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
has related synonym: sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
id: GO:0000252
type: Class
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
subclass of: GO_0016616

3-keto sterol reductase activity
IAO_0000115: Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
has alternative id: GO:0050576
has db xref: EC:1.1.1.270
has db xref: MetaCyc:1.1.1.270-RXN
has db xref: MetaCyc:RXN3O-4110
has db xref: MetaCyc:RXN66-19
has db xref: MetaCyc:RXN66-24
has db xref: MetaCyc:RXN66-314
has db xref: MetaCyc:RXN66-319
has db xref: RHEA:18412
has db xref: Reactome:REACT_10036
has db xref: Reactome:REACT_10079
has db xref: Reactome:REACT_101014
has db xref: Reactome:REACT_102533
has db xref: Reactome:REACT_103243
has db xref: Reactome:REACT_103645
has db xref: Reactome:REACT_106908
has db xref: Reactome:REACT_107179
has db xref: Reactome:REACT_108259
has db xref: Reactome:REACT_31386
has db xref: Reactome:REACT_69122
has db xref: Reactome:REACT_78849
has db xref: Reactome:REACT_79755
has db xref: Reactome:REACT_82599
has db xref: Reactome:REACT_82943
has db xref: Reactome:REACT_84146
has db xref: Reactome:REACT_88684
has db xref: Reactome:REACT_91551
has db xref: Reactome:REACT_92714
has db xref: Reactome:REACT_95205
has db xref: Reactome:REACT_96469
has db xref: Reactome:REACT_96959
has db xref: Reactome:REACT_96973
has db xref: Reactome:REACT_97126
has exact synonym: 3-KSR activity
has exact synonym: 3-keto-steroid reductase activity
has OBO namespace: molecular_function
has related synonym: 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
id: GO:0000253
type: Class
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
subclass of: GO_0016616

C-4 methylsterol oxidase activity
IAO_0000115: Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.
has db xref: EC:1.14.13.72
has db xref: MetaCyc:1.14.13.72-RXN
has db xref: Reactome:REACT_10059
has db xref: Reactome:REACT_10070
has db xref: Reactome:REACT_104089
has db xref: Reactome:REACT_104631
has db xref: Reactome:REACT_105610
has db xref: Reactome:REACT_105653
has db xref: Reactome:REACT_107576
has db xref: Reactome:REACT_112865
has db xref: Reactome:REACT_115505
has db xref: Reactome:REACT_28712
has db xref: Reactome:REACT_29355
has db xref: Reactome:REACT_31445
has db xref: Reactome:REACT_32207
has db xref: Reactome:REACT_32840
has db xref: Reactome:REACT_76969
has db xref: Reactome:REACT_79112
has db xref: Reactome:REACT_83222
has db xref: Reactome:REACT_84661
has db xref: Reactome:REACT_84707
has db xref: Reactome:REACT_85609
has db xref: Reactome:REACT_86519
has db xref: Reactome:REACT_88988
has db xref: Reactome:REACT_89551
has db xref: Reactome:REACT_94158
has db xref: Reactome:REACT_95387
has db xref: Reactome:REACT_95721
has db xref: Reactome:REACT_96643
has db xref: Reactome:REACT_97328
has db xref: Reactome:REACT_99679
has db xref: Reactome:REACT_99766
has exact synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)
has exact synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
has exact synonym: 4-methylsterol oxidase activity
has OBO namespace: molecular_function
has related synonym: methylsterol hydroxylase activity
has related synonym: methylsterol monooxygenase activity
id: GO:0000254
type: Class
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
subclass of: GO_0016709

allantoin metabolic process
IAO_0000115: The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.
has exact synonym: allantoin metabolism
has OBO namespace: biological_process
id: GO:0000255
in subset: gosubset prok
type: Class
subclass of: GO_0043603
subclass of: GO_0046483
subclass of: GO_1901360
subclass of: GO_1901564

allantoin catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.
has exact synonym: allantoin breakdown
has exact synonym: allantoin catabolism
has exact synonym: allantoin degradation
has OBO namespace: biological_process
id: GO:0000256
in subset: gosubset prok
type: Class
subclass of: allantoin metabolic process
subclass of: GO_0043605
subclass of: GO_0046700
subclass of: GO_1901361
subclass of: GO_1901565

nitrilase activity
IAO_0000115: Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
has db xref: EC:3.5.5.1
has db xref: MetaCyc:3.5.5.1-RXN
has db xref: RHEA:21727
has db xref: UM-BBD_enzymeID:e0283
has exact synonym: acetonitrilase activity
has exact synonym: benzonitrilase activity
has exact synonym: nitrile aminohydrolase activity
has OBO namespace: molecular_function
id: GO:0000257
in subset: gosubset prok
type: Class
subclass of: GO_0016815

isoleucine/valine:sodium symporter activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in).
consider: GO:0005283
consider: GO:0005304
consider: GO:0015188
has OBO namespace: molecular_function
id: GO:0000258
type: Class
comment: This term was made obsolete because it represents a multifunctional gene product.
deprecated: true

intracellular nucleoside transmembrane transporter activity
IAO_0000115: OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell.
IAO_0100001: GO:0005337
IAO_0100001: GO:0005622
has OBO namespace: molecular_function
id: GO:0000259
type: Class
comment: This term was made obsolete because it contains component and function information.
deprecated: true

hydrogen-translocating V-type ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria.
IAO_0100001: GO:0046961
has OBO namespace: molecular_function
id: GO:0000260
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

sodium-translocating V-type ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria.
IAO_0100001: GO:0046962
has OBO namespace: molecular_function
id: GO:0000261
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

mitochondrial chromosome
IAO_0000115: A chromosome found in the mitochondrion of a eukaryotic cell.
has db xref: NIF_Subcellular:sao1186327184
has narrow synonym: mitochondrial DNA
has narrow synonym: mtDNA
has OBO namespace: cellular_component
has related synonym: mitochondrial genome
id: GO:0000262
type: Class
subclass of: cytoplasmic chromosome
subclass of: GO_0044429
subclass of: Restriction
  on property: part_of
  some values from: GO_0042645
subclass of: Restriction
  on property: part_of
  some values from: GO_0005739

heterotrimeric G-protein GTPase, alpha-subunit
IAO_0000115: OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity.
consider: GO:0003924
consider: GO:0005834
has OBO namespace: molecular_function
id: GO:0000263
type: Class
comment: This term was made obsolete because it does not represent a molecular function.
deprecated: true

heterotrimeric G-protein GTPase, beta-subunit
IAO_0000115: OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit.
consider: GO:0003924
consider: GO:0005834
has OBO namespace: molecular_function
id: GO:0000264
type: Class
comment: This term was made obsolete because it does not represent a molecular function.
deprecated: true

heterotrimeric G-protein GTPase, gamma-subunit
IAO_0000115: OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit.
consider: GO:0003924
consider: GO:0005834
has OBO namespace: molecular_function
id: GO:0000265
type: Class
comment: This term was made obsolete because it does not represent a molecular function.
deprecated: true

mitochondrial fission
IAO_0000115: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
has exact synonym: mitochondrial division
has OBO namespace: biological_process
has related synonym: mitochondrial proliferation
id: GO:0000266
type: Class
subclass of: GO_0007005
subclass of: GO_0048285

cell fraction
IAO_0000115: OBSOLETE: A generic term for parts of cells prepared by disruptive biochemical techniques.
consider: GO:0005575
has OBO namespace: cellular_component
id: GO:0000267
in subset: goslim pir
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
deprecated: true

peroxisome targeting sequence binding
IAO_0000115: Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome.
has alternative id: GO:0005051
has exact synonym: PTS binding
has narrow synonym: PTS receptor
has narrow synonym: peroxisome targeting signal receptor
has OBO namespace: molecular_function
id: GO:0000268
type: Class
subclass of: GO_0005048

toxin export channel activity
IAO_0000115: Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
has OBO namespace: molecular_function
id: GO:0000269
type: Class
subclass of: GO_0015288
subclass of: GO_0019534

peptidoglycan metabolic process
IAO_0000115: The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.
has alternative id: GO:0009284
has exact synonym: murein metabolic process
has exact synonym: murein metabolism
has exact synonym: peptidoglycan metabolism
has OBO namespace: biological_process
id: GO:0000270
in subset: gosubset prok
type: Class
subclass of: GO_0030203

polysaccharide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.
has exact synonym: glycan biosynthesis
has exact synonym: glycan biosynthetic process
has exact synonym: polysaccharide anabolism
has exact synonym: polysaccharide biosynthesis
has exact synonym: polysaccharide formation
has exact synonym: polysaccharide synthesis
has OBO namespace: biological_process
id: GO:0000271
in subset: gosubset prok
type: Class
subclass of: GO_0005976
subclass of: GO_0009059
subclass of: GO_0016051

polysaccharide catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.
has exact synonym: polysaccharide breakdown
has exact synonym: polysaccharide catabolism
has exact synonym: polysaccharide degradation
has OBO namespace: biological_process
id: GO:0000272
in subset: gosubset prok
type: Class
subclass of: GO_0005976
subclass of: GO_0009057
subclass of: GO_0044724

mitochondrial proton-transporting ATP synthase, stator stalk
IAO_0000115: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.
has OBO namespace: cellular_component
id: GO:0000274
type: Class
subclass of: GO_0044455
subclass of: GO_0045265
subclass of: Restriction
  on property: part_of
  some values from: GO_0005739
subclass of: Restriction
  on property: part_of
  some values from: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
IAO_0000115: The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.
has broad synonym: hydrogen-transporting ATP synthase, F1 sector
has broad synonym: proton-transporting ATP synthase complex, catalytic core F(1)
has OBO namespace: cellular_component
id: GO:0000275
type: Class
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
subclass of: GO_0044455
subclass of: GO_0045261
subclass of: Restriction
  on property: part_of
  some values from: GO_0005753
subclass of: Restriction
  on property: part_of
  some values from: GO_0005739

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
IAO_0000115: All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.
has OBO namespace: cellular_component
id: GO:0000276
type: Class
subclass of: GO_0044455
subclass of: GO_0045263
subclass of: Restriction
  on property: part_of
  some values from: GO_0005753
subclass of: Restriction
  on property: part_of
  some values from: GO_0005739

[cytochrome c]-lysine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c.
has db xref: EC:2.1.1.59
has db xref: MetaCyc:2.1.1.59-RXN
has exact synonym: S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity
has exact synonym: cytochrome c (lysine) methyltransferase activity
has exact synonym: cytochrome c methyltransferase activity
has exact synonym: cytochrome c-lysine N-methyltransferase activity
has exact synonym: cytochrome c-specific protein methylase III activity
has exact synonym: cytochrome c-specific protein-lysine methyltransferase activity
has OBO namespace: molecular_function
id: GO:0000277
type: Class
subclass of: GO_0016279

mitotic cell cycle
IAO_0000115: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has db xref: Reactome:REACT_100451
has db xref: Reactome:REACT_104035
has db xref: Reactome:REACT_104195
has db xref: Reactome:REACT_105856
has db xref: Reactome:REACT_108233
has db xref: Reactome:REACT_152
has db xref: Reactome:REACT_28464
has db xref: Reactome:REACT_28953
has db xref: Reactome:REACT_33388
has db xref: Reactome:REACT_53493
has db xref: Reactome:REACT_79085
has db xref: Reactome:REACT_84794
has db xref: Reactome:REACT_85137
has db xref: Reactome:REACT_85950
has db xref: Reactome:REACT_90332
has db xref: Reactome:REACT_90846
has db xref: Reactome:REACT_96281
has db xref: Reactome:REACT_97744
has db xref: Reactome:REACT_98208
has OBO namespace: biological_process
id: GO:0000278
in subset: goslim yeast
type: Class
subclass of: GO_0007049

M phase
IAO_0000115: A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.
has db xref: Wikipedia:M_phase
has exact synonym: M-phase
has OBO namespace: biological_process
id: GO:0000279
type: Class
subclass of: GO_0022403

nuclear division
IAO_0000115: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
has OBO namespace: biological_process
has related synonym: karyokinesis
id: GO:0000280
in subset: goslim pir
type: Class
subclass of: GO_0048285

cytokinesis after mitosis
IAO_0000115: A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
has OBO namespace: biological_process
id: GO:0000281
type: Class
subclass of: GO_0033205

cellular bud site selection
IAO_0000115: The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
has broad synonym: bud site selection/establishment of cell polarity
has OBO namespace: biological_process
id: GO:0000282
type: Class
comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010).
subclass of: GO_0007105
subclass of: GO_0030010
subclass of: Restriction
  on property: part_of
  some values from: GO_0033205

shmoo orientation
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0000753
has OBO namespace: biological_process
id: GO:0000284
type: Class
comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable.
deprecated: true

1-phosphatidylinositol-3-phosphate 5-kinase activity
IAO_0000115: Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
has db xref: EC:2.7.1.150
has db xref: KEGG:R05802
has db xref: MetaCyc:2.7.1.150-RXN
has db xref: RHEA:13612
has exact synonym: ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity
has exact synonym: phosphatidylinositol 3-phosphate 5-kinase activity
has exact synonym: phosphatidylinositol-3-phosphate 5-kinase activity
has OBO namespace: molecular_function
has related synonym: type III PIP kinase activity
id: GO:0000285
type: Class
subclass of: GO_0016307

alanine dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+).
has db xref: EC:1.4.1.1
has db xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN
has db xref: RHEA:18408
has exact synonym: L-alanine dehydrogenase activity
has exact synonym: L-alanine:NAD+ oxidoreductase (deaminating)
has exact synonym: NAD-dependent alanine dehydrogenase activity
has exact synonym: NAD-linked alanine dehydrogenase activity
has exact synonym: NADH-dependent alanine dehydrogenase activity
has exact synonym: alanine oxidoreductase activity
has exact synonym: alpha-alanine dehydrogenase activity
has OBO namespace: molecular_function
has related synonym: AlaDH
id: GO:0000286
in subset: gosubset prok
type: Class
subclass of: GO_0016638

magnesium ion binding
IAO_0000115: Interacting selectively and non-covalently with magnesium (Mg) ions.
has exact synonym: magnesium binding
has OBO namespace: molecular_function
id: GO:0000287
in subset: gosubset prok
type: Class
subclass of: GO_0046872

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
IAO_0000115: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
has db xref: Reactome:REACT_102357
has db xref: Reactome:REACT_103296
has db xref: Reactome:REACT_105200
has db xref: Reactome:REACT_110041
has db xref: Reactome:REACT_20639
has db xref: Reactome:REACT_49520
has db xref: Reactome:REACT_79530
has db xref: Reactome:REACT_82315
has db xref: Reactome:REACT_83961
has db xref: Reactome:REACT_89647
has db xref: Reactome:REACT_90397
has db xref: Reactome:REACT_93483
has db xref: Reactome:REACT_95045
has db xref: Reactome:REACT_95337
has db xref: Reactome:REACT_96238
has db xref: Reactome:REACT_96993
has db xref: Reactome:REACT_97186
has db xref: Reactome:REACT_99680
has exact synonym: deadenylation-dependent mRNA decay
has exact synonym: mRNA breakdown, deadenylation-dependent decay
has exact synonym: mRNA catabolic process, deadenylation-dependent
has exact synonym: mRNA catabolic process, deadenylylation-dependent
has exact synonym: mRNA catabolism, deadenylation-dependent
has exact synonym: mRNA catabolism, deadenylylation-dependent
has exact synonym: mRNA degradation, deadenylation-dependent decay
has exact synonym: nuclear mRNA catabolic process, deadenylation-dependent decay
has OBO namespace: biological_process
id: GO:0000288
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA poly(A) tail shortening
IAO_0000115: Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
has db xref: Reactome:REACT_102415
has db xref: Reactome:REACT_104397
has db xref: Reactome:REACT_109691
has db xref: Reactome:REACT_111968
has db xref: Reactome:REACT_20514
has db xref: Reactome:REACT_30693
has db xref: Reactome:REACT_31579
has db xref: Reactome:REACT_78492
has db xref: Reactome:REACT_83021
has OBO namespace: biological_process
has related synonym: 3' to 5' mRNA deadenylation
has related synonym: mRNA deadenylation
has related synonym: nuclear mRNA poly(A) tail shortening
id: GO:0000289
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
subclass of: GO_0031124
subclass of: Restriction
  on property: part_of
  some values from: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

deadenylation-dependent decapping of nuclear-transcribed mRNA
IAO_0000115: Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
has exact synonym: deadenylation-dependent decapping of nuclear mRNA
has exact synonym: deadenylylation-dependent decapping
has OBO namespace: biological_process
id: GO:0000290
type: Class
subclass of: nuclear-transcribed mRNA catabolic process
subclass of: Restriction
  on property: part_of
  some values from: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nuclear-transcribed mRNA catabolic process, exonucleolytic
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail.
has exact synonym: exonucleolytic degradation of mRNA
has exact synonym: mRNA breakdown, exonucleolytic
has exact synonym: mRNA degradation, exonucleolytic
has exact synonym: nuclear mRNA catabolic process, exonucleolytic
has OBO namespace: biological_process
id: GO:0000291
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

RNA fragment catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing.
has alternative id: GO:0030452
has exact synonym: RNA fragment breakdown
has exact synonym: RNA fragment catabolism
has exact synonym: RNA fragment degradation
has narrow synonym: group I intron catabolic process
has OBO namespace: biological_process
id: GO:0000292
in subset: gosubset prok
type: Class
subclass of: GO_0006401

ferric-chelate reductase activity
IAO_0000115: Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+).
has db xref: EC:1.16.1.7
has db xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN
has db xref: RHEA:15064
has exact synonym: Fe(II):NAD+ oxidoreductase activity
has exact synonym: NADH2:Fe3+ oxidoreductase activity
has exact synonym: NADH:Fe(3+) oxidoreductase activity
has exact synonym: NADH:Fe(3+)-EDTA reductase activity
has exact synonym: NADH:Fe3+ oxidoreductase activity
has exact synonym: NADH:Fe3+-EDTA reductase activity
has exact synonym: ferric chelate reductase activity
has OBO namespace: molecular_function
has related synonym: iron chelate reductase activity
id: GO:0000293
type: Class
comment: Note that this function was formerly EC:1.6.99.13.
subclass of: GO_0016723

nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
IAO_0000115: A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.
has exact synonym: endonucleolytic mRNA decay
has exact synonym: mRNA breakdown, endonucleolytic cleavage-dependent decay
has exact synonym: mRNA catabolic process, endonucleolytic
has exact synonym: mRNA catabolism, endonucleolytic
has exact synonym: mRNA degradation, endonucleolytic cleavage-dependent decay
has exact synonym: nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay
has OBO namespace: biological_process
id: GO:0000294
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

adenine nucleotide transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other.
has db xref: Reactome:REACT_101864
has db xref: Reactome:REACT_107442
has db xref: Reactome:REACT_113419
has db xref: Reactome:REACT_16948
has db xref: Reactome:REACT_28950
has db xref: Reactome:REACT_30244
has db xref: Reactome:REACT_33254
has db xref: Reactome:REACT_80715
has db xref: Reactome:REACT_83323
has db xref: Reactome:REACT_85299
has db xref: Reactome:REACT_86138
has db xref: Reactome:REACT_86805
has db xref: Reactome:REACT_89005
has db xref: Reactome:REACT_91614
has OBO namespace: molecular_function
id: GO:0000295
type: Class
subclass of: GO_0015216

spermine transport
IAO_0000115: The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has OBO namespace: biological_process
id: GO:0000296
type: Class
subclass of: GO_0006812
subclass of: GO_0015846

spermine transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
has OBO namespace: molecular_function
id: GO:0000297
type: Class
subclass of: GO_0008324
subclass of: GO_0015203

endopolyphosphatase activity
IAO_0000115: Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.
has broad synonym: metaphosphatase activity
has broad synonym: polyphosphatase activity
has broad synonym: polyphosphate depolymerase activity
has db xref: EC:3.6.1.10
has db xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN
has exact synonym: polymetaphosphatase activity
has exact synonym: polyphosphate polyphosphohydrolase activity
has OBO namespace: molecular_function
id: GO:0000298
type: Class
subclass of: GO_0016462

integral to membrane of membrane fraction
IAO_0000115: OBSOLETE: Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes.
consider: GO:0016021
has OBO namespace: cellular_component
id: GO:0000299
type: Class
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
deprecated: true

peripheral to membrane of membrane fraction
IAO_0000115: OBSOLETE: Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH.
consider: GO:0019898
has OBO namespace: cellular_component
id: GO:0000300
type: Class
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
deprecated: true

retrograde transport, vesicle recycling within Golgi
IAO_0000115: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.
has exact synonym: retrograde (vesicle recycling within Golgi) transport
has OBO namespace: biological_process
id: GO:0000301
type: Class
subclass of: GO_0006891

response to reactive oxygen species
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
has exact synonym: response to AOS
has exact synonym: response to ROI
has exact synonym: response to ROS
has exact synonym: response to active oxygen species
has exact synonym: response to reactive oxidative species
has exact synonym: response to reactive oxygen intermediate
has OBO namespace: biological_process
id: GO:0000302
in subset: gosubset prok
type: Class
subclass of: GO_0006979
subclass of: GO_1901700

response to superoxide
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
has OBO namespace: biological_process
id: GO:0000303
in subset: gosubset prok
type: Class
subclass of: response to reactive oxygen species

response to singlet oxygen
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.
has OBO namespace: biological_process
id: GO:0000304
in subset: gosubset prok
type: Class
subclass of: response to reactive oxygen species

response to oxygen radical
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion.
has OBO namespace: biological_process
id: GO:0000305
in subset: gosubset prok
type: Class
subclass of: response to reactive oxygen species

extrinsic to vacuolar membrane
IAO_0000115: Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region.
has OBO namespace: cellular_component
id: GO:0000306
type: Class
subclass of: GO_0031312
subclass of: GO_0044437
subclass of: Restriction
  on property: part_of
  some values from: GO_0005774

cyclin-dependent protein kinase holoenzyme complex
IAO_0000115: Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
has exact synonym: CDK holoenzyme
has OBO namespace: cellular_component
id: GO:0000307
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044424

cytoplasmic cyclin-dependent protein kinase holoenzyme complex
IAO_0000115: Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
has broad synonym: CDK holoenzyme
has OBO namespace: cellular_component
id: GO:0000308
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737

nicotinamide-nucleotide adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.
has db xref: EC:2.7.7.1
has db xref: MetaCyc:2.7.7.1-RXN
has db xref: RHEA:21363
has db xref: Reactome:REACT_101807
has db xref: Reactome:REACT_102033
has db xref: Reactome:REACT_103802
has db xref: Reactome:REACT_105839
has db xref: Reactome:REACT_107769
has db xref: Reactome:REACT_107952
has db xref: Reactome:REACT_108630
has db xref: Reactome:REACT_108997
has db xref: Reactome:REACT_11116
has db xref: Reactome:REACT_11196
has db xref: Reactome:REACT_112138
has db xref: Reactome:REACT_11237
has db xref: Reactome:REACT_112385
has db xref: Reactome:REACT_114383
has db xref: Reactome:REACT_114560
has db xref: Reactome:REACT_114828
has db xref: Reactome:REACT_115028
has db xref: Reactome:REACT_29972
has db xref: Reactome:REACT_30979
has db xref: Reactome:REACT_31171
has db xref: Reactome:REACT_31453
has db xref: Reactome:REACT_70840
has db xref: Reactome:REACT_77837
has db xref: Reactome:REACT_78904
has db xref: Reactome:REACT_79519
has db xref: Reactome:REACT_79745
has db xref: Reactome:REACT_79909
has db xref: Reactome:REACT_80724
has db xref: Reactome:REACT_80917
has db xref: Reactome:REACT_81520
has db xref: Reactome:REACT_81532
has db xref: Reactome:REACT_83285
has db xref: Reactome:REACT_84119
has db xref: Reactome:REACT_86854
has db xref: Reactome:REACT_90006
has db xref: Reactome:REACT_92077
has db xref: Reactome:REACT_93517
has db xref: Reactome:REACT_95186
has db xref: Reactome:REACT_96395
has db xref: Reactome:REACT_96707
has db xref: Reactome:REACT_97201
has db xref: Reactome:REACT_97323
has db xref: Reactome:REACT_97434
has db xref: Reactome:REACT_98853
has exact synonym: ATP:NMN adenylyltransferase activity
has exact synonym: ATP:nicotinamide-nucleotide adenylyltransferase activity
has exact synonym: NAD+ diphosphorylase activity
has exact synonym: NAD+ pyrophosphorylase activity
has exact synonym: adenosine triphosphate-nicotinamide mononucleotide transadenylase activity
has narrow synonym: NAD(+) diphosphorylase activity
has narrow synonym: NAD(+) pyrophosphorylase activity
has narrow synonym: NMN adenylyltransferase activity
has narrow synonym: NMNAT activity
has narrow synonym: nicotinamide adenine dinucleotide pyrophosphorylase activity
has narrow synonym: nicotinamide mononucleotide adenylyltransferase activity
has OBO namespace: molecular_function
has related synonym: diphosphopyridine nucleotide pyrophosphorylase activity
id: GO:0000309
in subset: gosubset prok
type: Class
subclass of: GO_0070566

xanthine phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate.
has alternative id: GO:0009043
has db xref: EC:2.4.2.22
has db xref: MetaCyc:XANPRIBOSYLTRAN-RXN
has db xref: RHEA:10803
has exact synonym: 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity
has exact synonym: XMP pyrophosphorylase activity
has exact synonym: XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity
has exact synonym: Xan phosphoribosyltransferase activity
has exact synonym: xanthine-guanine phosphoribosyltransferase activity
has exact synonym: xanthosine 5'-phosphate pyrophosphorylase activity
has exact synonym: xanthylate pyrophosphorylase activity
has exact synonym: xanthylic pyrophosphorylase activity
has OBO namespace: molecular_function
id: GO:0000310
in subset: gosubset prok
type: Class
subclass of: GO_0016763

plastid large ribosomal subunit
IAO_0000115: The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
has OBO namespace: cellular_component
id: GO:0000311
type: Class
subclass of: organellar large ribosomal subunit
subclass of: GO_0044435
subclass of: Restriction
  on property: part_of
  some values from: GO_0009547

plastid small ribosomal subunit
IAO_0000115: The smaller of the two subunits of a plastid ribosome.
has OBO namespace: cellular_component
id: GO:0000312
type: Class
subclass of: organellar small ribosomal subunit
subclass of: GO_0044435
subclass of: Restriction
  on property: part_of
  some values from: GO_0009547

organellar ribosome
IAO_0000115: A ribosome contained within a subcellular membrane-bounded organelle.
has OBO namespace: cellular_component
id: GO:0000313
type: Class
subclass of: GO_0005840
subclass of: GO_0044422
subclass of: Restriction
  on property: part_of
  some values from: GO_0043226

organellar small ribosomal subunit
IAO_0000115: The smaller of the two subunits of an organellar ribosome.
has OBO namespace: cellular_component
id: GO:0000314
type: Class
subclass of: GO_0015935
subclass of: Restriction
  on property: part_of
  some values from: organellar ribosome

organellar large ribosomal subunit
IAO_0000115: The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
has OBO namespace: cellular_component
id: GO:0000315
type: Class
subclass of: GO_0015934
subclass of: Restriction
  on property: part_of
  some values from: organellar ribosome

sulfite transport
IAO_0000115: The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: sulphite transport
has OBO namespace: biological_process
id: GO:0000316
type: Class
subclass of: GO_0015698
subclass of: GO_0072348

sulfite transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of sulfite ions from one side of a membrane to the other.
has exact synonym: sulphite transporter activity
has OBO namespace: molecular_function
id: GO:0000319
type: Class
subclass of: GO_0015103
subclass of: GO_1901682

re-entry into mitotic cell cycle
IAO_0000115: The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.
has OBO namespace: biological_process
id: GO:0000320
type: Class
subclass of: GO_0022402

re-entry into mitotic cell cycle after pheromone arrest
IAO_0000115: The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.
has OBO namespace: biological_process
id: GO:0000321
type: Class
subclass of: re-entry into mitotic cell cycle
subclass of: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion

storage vacuole
IAO_0000115: A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.
has OBO namespace: cellular_component
id: GO:0000322
type: Class
subclass of: GO_0005773

lytic vacuole
IAO_0000115: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.
has OBO namespace: cellular_component
id: GO:0000323
type: Class
subclass of: GO_0005773

fungal-type vacuole
IAO_0000115: A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
has exact synonym: vacuole, cell cycle-correlated morphology
has OBO namespace: cellular_component
id: GO:0000324
type: Class
subclass of: storage vacuole
subclass of: lytic vacuole

plant-type vacuole
IAO_0000115: A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
has exact synonym: vacuole, cell cycle-independent morphology
has OBO namespace: cellular_component
id: GO:0000325
type: Class
subclass of: GO_0005773

protein storage vacuole
IAO_0000115: A storage vacuole that contains a lytic vacuole; identified in plants.
has OBO namespace: cellular_component
id: GO:0000326
type: Class
subclass of: storage vacuole
subclass of: plant-type vacuole

lytic vacuole within protein storage vacuole
IAO_0000115: A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole.
has OBO namespace: cellular_component
id: GO:0000327
type: Class
subclass of: lytic vacuole
subclass of: GO_0044437
subclass of: Restriction
  on property: part_of
  some values from: protein storage vacuole

fungal-type vacuole lumen
IAO_0000115: The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: lumen of vacuole with cell cycle-correlated morphology
has OBO namespace: cellular_component
id: GO:0000328
type: Class
subclass of: GO_0005775
subclass of: Restriction
  on property: part_of
  some values from: fungal-type vacuole

fungal-type vacuole membrane
IAO_0000115: The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: membrane of vacuole with cell cycle-correlated morphology
has OBO namespace: cellular_component
has related synonym: fungal-type vacuolar membrane
id: GO:0000329
type: Class
subclass of: GO_0005774
subclass of: Restriction
  on property: part_of
  some values from: fungal-type vacuole

plant-type vacuole lumen
IAO_0000115: The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana.
has exact synonym: lumen of vacuole with cell cycle-independent morphology
has OBO namespace: cellular_component
id: GO:0000330
type: Class
subclass of: GO_0005775
subclass of: Restriction
  on property: part_of
  some values from: plant-type vacuole

contractile vacuole
IAO_0000115: A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.
has db xref: Wikipedia:Contractile_vacuole
has OBO namespace: cellular_component
id: GO:0000331
type: Class
subclass of: GO_0005773
subclass of: GO_0016023

template for synthesis of G-rich strand of telomere DNA activity
IAO_0000115: Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA.
has exact synonym: telomerase RNA
has exact synonym: telomerase, template
has OBO namespace: molecular_function
id: GO:0000332
type: Class
comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins.
subclass of: base pairing with DNA
subclass of: Restriction
  on property: part_of
  some values from: telomerase activity

telomerase catalytic core complex
IAO_0000115: The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.
has OBO namespace: cellular_component
id: GO:0000333
type: Class
subclass of: GO_0005697

3-hydroxyanthranilate 3,4-dioxygenase activity
IAO_0000115: Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+).
has db xref: EC:1.13.11.6
has db xref: KEGG:R02665
has db xref: MetaCyc:1.13.11.6-RXN
has db xref: RHEA:17956
has db xref: Reactome:REACT_106067
has db xref: Reactome:REACT_107237
has db xref: Reactome:REACT_108663
has db xref: Reactome:REACT_108942
has db xref: Reactome:REACT_612
has db xref: Reactome:REACT_78765
has db xref: Reactome:REACT_81621
has db xref: Reactome:REACT_83535
has db xref: Reactome:REACT_83862
has db xref: Reactome:REACT_84121
has db xref: Reactome:REACT_86308
has db xref: Reactome:REACT_93632
has db xref: Reactome:REACT_94190
has db xref: UM-BBD_reactionID:r1027
has exact synonym: 3-hydroxyanthranilate oxygenase activity
has exact synonym: 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
has exact synonym: 3-hydroxyanthranilic acid dioxygenase activity
has exact synonym: 3-hydroxyanthranilic acid oxygenase activity
has exact synonym: 3-hydroxyanthranilic oxygenase activity
has OBO namespace: molecular_function
has related synonym: 3HAO
id: GO:0000334
in subset: gosubset prok
type: Class
subclass of: GO_0016702

negative regulation of transposition, DNA-mediated
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition.
has exact synonym: down regulation of DNA transposition
has exact synonym: down-regulation of DNA transposition
has exact synonym: downregulation of DNA transposition
has exact synonym: negative regulation of DNA transposition
has narrow synonym: inhibition of DNA transposition
has OBO namespace: biological_process
id: GO:0000335
in subset: gosubset prok
type: Class
subclass of: regulation of transposition, DNA-mediated
subclass of: GO_0010529
subclass of: GO_0045910
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0006313

positive regulation of transposition, DNA-mediated
IAO_0000115: Any process that activates or increases the frequency, rate or extent of DNA transposition.
has exact synonym: positive regulation of DNA transposition
has exact synonym: up regulation of DNA transposition
has exact synonym: up-regulation of DNA transposition
has exact synonym: upregulation of DNA transposition
has narrow synonym: activation of DNA transposition
has narrow synonym: stimulation of DNA transposition
has OBO namespace: biological_process
id: GO:0000336
in subset: gosubset prok
type: Class
subclass of: regulation of transposition, DNA-mediated
subclass of: GO_0010530
subclass of: GO_0045911
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0006313

regulation of transposition, DNA-mediated
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule.
has exact synonym: regulation of DNA transposition
has OBO namespace: biological_process
id: GO:0000337
in subset: gosubset prok
type: Class
subclass of: regulation of DNA recombination
subclass of: GO_0010528
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006313

protein deneddylation
IAO_0000115: The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
has OBO namespace: biological_process
id: GO:0000338
type: Class
subclass of: GO_0070646

RNA cap binding
IAO_0000115: Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
has narrow synonym: binding to mRNA cap
has narrow synonym: mRNA cap binding
has narrow synonym: snRNA cap binding
has OBO namespace: molecular_function
id: GO:0000339
type: Class
subclass of: RNA binding

RNA 7-methylguanosine cap binding
IAO_0000115: Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
has exact synonym: RNA m7G cap binding
has OBO namespace: molecular_function
id: GO:0000340
type: Class
subclass of: RNA cap binding

RNA trimethylguanosine cap binding
IAO_0000115: Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans.
has exact synonym: RNA m2,2,7G cap binding
has OBO namespace: molecular_function
id: GO:0000341
type: Class
subclass of: RNA cap binding

RNA cap 4 binding
IAO_0000115: Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa.
has OBO namespace: molecular_function
id: GO:0000342
type: Class
subclass of: RNA cap binding

plastid-encoded plastid RNA polymerase complex A
IAO_0000115: A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex.
has exact synonym: PEP-A
has OBO namespace: cellular_component
id: GO:0000343
type: Class
subclass of: plastid-encoded plastid RNA polymerase complex

plastid-encoded plastid RNA polymerase complex B
IAO_0000115: A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation.
has exact synonym: PEP-B
has OBO namespace: cellular_component
id: GO:0000344
type: Class
subclass of: plastid-encoded plastid RNA polymerase complex

cytosolic DNA-directed RNA polymerase complex
IAO_0000115: The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity.
has OBO namespace: cellular_component
id: GO:0000345
in subset: gosubset prok
type: Class
subclass of: DNA-directed RNA polymerase complex
subclass of: GO_0044445

transcription export complex
IAO_0000115: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
has exact synonym: TREX complex
has OBO namespace: cellular_component
id: GO:0000346
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044428

THO complex
IAO_0000115: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
has OBO namespace: cellular_component
id: GO:0000347
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044428

mRNA branch site recognition
IAO_0000115: Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome.
has alternative id: GO:0000370
has alternative id: GO:0000371
has exact synonym: nuclear mRNA branch site recognition
has narrow synonym: U12-type nuclear mRNA branch site recognition
has narrow synonym: U2-type nuclear mRNA branch site recognition
has narrow synonym: spliceosomal A complex biosynthesis
has narrow synonym: spliceosomal A complex formation
has narrow synonym: spliceosomal B complex biosynthesis
has narrow synonym: spliceosomal B complex formation
has OBO namespace: biological_process
id: GO:0000348
type: Class
comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian).
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal complex assembly

generation of catalytic spliceosome for first transesterification step
IAO_0000115: Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome.
has alternative id: GO:0000356
has alternative id: GO:0000357
has exact synonym: formation of catalytic spliceosome for first transesterification step
has narrow synonym: U12-type catalytic spliceosome formation for first transesterification step
has narrow synonym: U2-type catalytic spliceosome formation for first transesterification step
has narrow synonym: spliceosomal A2-2 complex biosynthesis
has narrow synonym: spliceosomal A2-2 complex formation
has narrow synonym: spliceosomal C1 complex biosynthesis
has narrow synonym: spliceosomal C1 complex formation
has OBO namespace: biological_process
has related synonym: catalytic spliceosome assembly for first transesterification step
id: GO:0000349
type: Class
comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian).
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal conformational changes to generate catalytic conformation

generation of catalytic spliceosome for second transesterification step
IAO_0000115: Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.
has alternative id: GO:0000358
has alternative id: GO:0000359
has exact synonym: formation of catalytic spliceosome for second transesterification step
has narrow synonym: formation of catalytic U12-type spliceosome for second transesterification step
has narrow synonym: formation of catalytic U2-type spliceosome for second transesterification step
has narrow synonym: formation of spliceosomal A2-2 complex
has narrow synonym: formation of spliceosomal C1 complex
has narrow synonym: spliceosomal A2-3 complex biosynthesis
has narrow synonym: spliceosomal A2-3 complex formation
has narrow synonym: spliceosomal C2 complex biosynthesis
has narrow synonym: spliceosomal C2 complex formation
has OBO namespace: biological_process
has related synonym: catalytic spliceosome assembly for second transesterification step
has related synonym: lariat formation, 5'-splice site cleavage
id: GO:0000350
type: Class
comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian).
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal conformational changes to generate catalytic conformation

trans assembly of SL-containing precatalytic spliceosome
IAO_0000115: Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA.
has exact synonym: trans assembly of spliced leader-containing precatalytic spliceosome
has OBO namespace: biological_process
id: GO:0000352
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0045291
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal complex assembly

formation of quadruple SL/U4/U5/U6 snRNP
IAO_0000115: Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA.
has OBO namespace: biological_process
id: GO:0000353
type: Class
comment: Note that this step is analogous to 5' splice site selection in cis-splicing.
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0045291

cis assembly of pre-catalytic spliceosome
IAO_0000115: Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.
has alternative id: GO:0000360
has alternative id: GO:0000361
has narrow synonym: cis assembly of U12-type pre-catalytic spliceosome
has narrow synonym: cis assembly of U2-type pre-catalytic spliceosome
has narrow synonym: formation of spliceosomal A2-1 complex
has narrow synonym: formation of spliceosomal B1 complex
has narrow synonym: spliceosomal A2-1 complex biosynthesis
has narrow synonym: spliceosomal A2-1 complex formation
has narrow synonym: spliceosomal B1 complex biosynthesis
has narrow synonym: spliceosomal B1 complex formation
has OBO namespace: biological_process
id: GO:0000354
type: Class
comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals).
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal complex assembly
subclass of: Restriction
  on property: part_of
  some values from: GO_0045292

first U2-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins.
IAO_0100001: GO:0000384
has broad synonym: lariat formation, 5'-splice site cleavage
has OBO namespace: molecular_function
id: GO:0000362
type: Class
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
deprecated: true

first U12-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins.
IAO_0100001: GO:0000384
has broad synonym: lariat formation, 5'-splice site cleavage
has OBO namespace: molecular_function
id: GO:0000363
type: Class
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
deprecated: true

second U2-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.
IAO_0100001: GO:0000386
has broad synonym: 3'-splice site cleavage, exon ligation
has OBO namespace: molecular_function
id: GO:0000364
type: Class
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
deprecated: true

mRNA trans splicing, via spliceosome
IAO_0000115: The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
has exact synonym: nuclear mRNA trans splicing, via spliceosome
has narrow synonym: nuclear mRNA trans splicing, via U2-type spliceosome
has OBO namespace: biological_process
id: GO:0000365
type: Class
subclass of: mRNA splicing, via spliceosome

intergenic mRNA trans splicing
IAO_0000115: The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing.
has exact synonym: intergenic nuclear mRNA trans splicing
has OBO namespace: biological_process
id: GO:0000366
type: Class
subclass of: mRNA trans splicing, via spliceosome
subclass of: alternative mRNA splicing, via spliceosome

second U12-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.
IAO_0100001: GO:0000386
has broad synonym: 3'-splice site cleavage, exon ligation
has OBO namespace: molecular_function
id: GO:0000367
type: Class
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
deprecated: true

Group I intron splicing
IAO_0000115: The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize).
has OBO namespace: biological_process
has related synonym: mRNA splicing
id: GO:0000372
in subset: gosubset prok
type: Class
comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone).
subclass of: RNA splicing, via transesterification reactions with guanosine as nucleophile

Group II intron splicing
IAO_0000115: The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat.
has OBO namespace: biological_process
has related synonym: mRNA splicing
id: GO:0000373
in subset: gosubset prok
type: Class
comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria.
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

Group III intron splicing
IAO_0000115: The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved.
has OBO namespace: biological_process
has related synonym: mRNA splicing
id: GO:0000374
in subset: gosubset prok
type: Class
comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists.
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

RNA splicing, via transesterification reactions
IAO_0000115: Splicing of RNA via a series of two transesterification reactions.
has alternative id: GO:0000385
has alternative id: GO:0031202
has OBO namespace: biological_process
has related synonym: RNA splicing factor activity, transesterification mechanism
has related synonym: pre-mRNA splicing factor activity
has related synonym: spliceosomal catalysis
id: GO:0000375
in subset: gosubset prok
type: Class
comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
subclass of: GO_0008380

RNA splicing, via transesterification reactions with guanosine as nucleophile
IAO_0000115: Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile.
has OBO namespace: biological_process
id: GO:0000376
in subset: gosubset prok
type: Class
subclass of: RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
IAO_0000115: Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.
has OBO namespace: biological_process
has related synonym: lariat RNA biosynthesis
has related synonym: lariat RNA formation
id: GO:0000377
in subset: gosubset prok
type: Class
subclass of: RNA splicing, via transesterification reactions

RNA exon ligation
IAO_0000115: The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.
has OBO namespace: biological_process
id: GO:0000378
in subset: gosubset prok
type: Class
comment: Note that this is not a part of spliceosomal RNA splicing.
subclass of: GO_0016070
subclass of: Restriction
  on property: part_of
  some values from: RNA splicing, via endonucleolytic cleavage and ligation

tRNA-type intron splice site recognition and cleavage
IAO_0000115: RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.
has OBO namespace: biological_process
id: GO:0000379
in subset: gosubset prok
type: Class
subclass of: GO_0006396
subclass of: Restriction
  on property: part_of
  some values from: GO_0006388

alternative mRNA splicing, via spliceosome
IAO_0000115: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
has broad synonym: splice site selection
has exact synonym: alternative nuclear mRNA splicing, via spliceosome
has OBO namespace: biological_process
id: GO:0000380
type: Class
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
subclass of: mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome
IAO_0000115: Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
has broad synonym: splice site selection
has exact synonym: regulation of alternative nuclear mRNA splicing, via spliceosome
has OBO namespace: biological_process
id: GO:0000381
type: Class
subclass of: GO_0048024
subclass of: Restriction
  on property: RO_0002211
  some values from: alternative mRNA splicing, via spliceosome

first spliceosomal transesterification activity
IAO_0000115: Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.
has OBO namespace: molecular_function
has related synonym: lariat formation, 5'-splice site cleavage
id: GO:0000384
type: Class
subclass of: catalytic activity

second spliceosomal transesterification activity
IAO_0000115: Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
has broad synonym: 3'-splice site cleavage, exon ligation
has OBO namespace: molecular_function
has related synonym: lariat formation, 5'-splice site cleavage
id: GO:0000386
type: Class
subclass of: catalytic activity

spliceosomal snRNP assembly
IAO_0000115: The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
has db xref: Reactome:REACT_10002
has db xref: Reactome:REACT_10041
has db xref: Reactome:REACT_100869
has db xref: Reactome:REACT_100915
has db xref: Reactome:REACT_101141
has db xref: Reactome:REACT_102135
has db xref: Reactome:REACT_102362
has db xref: Reactome:REACT_107811
has db xref: Reactome:REACT_108169
has db xref: Reactome:REACT_108689
has db xref: Reactome:REACT_109502
has db xref: Reactome:REACT_11066
has db xref: Reactome:REACT_112455
has db xref: Reactome:REACT_29060
has db xref: Reactome:REACT_29381
has db xref: Reactome:REACT_29703
has db xref: Reactome:REACT_29866
has db xref: Reactome:REACT_30125
has db xref: Reactome:REACT_30397
has db xref: Reactome:REACT_30799
has db xref: Reactome:REACT_30895
has db xref: Reactome:REACT_31007
has db xref: Reactome:REACT_31363
has db xref: Reactome:REACT_31615
has db xref: Reactome:REACT_32359
has db xref: Reactome:REACT_54083
has db xref: Reactome:REACT_77054
has db xref: Reactome:REACT_79845
has db xref: Reactome:REACT_81235
has db xref: Reactome:REACT_81911
has db xref: Reactome:REACT_82745
has db xref: Reactome:REACT_85882
has db xref: Reactome:REACT_86133
has db xref: Reactome:REACT_88437
has db xref: Reactome:REACT_88858
has db xref: Reactome:REACT_93259
has db xref: Reactome:REACT_93444
has db xref: Reactome:REACT_93869
has db xref: Reactome:REACT_95210
has db xref: Reactome:REACT_99021
has db xref: Reactome:REACT_9946
has db xref: Reactome:REACT_9957
has OBO namespace: biological_process
has related synonym: spliceosomal snRNP biogenesis
id: GO:0000387
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: mRNA splicing, via spliceosome

spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
IAO_0000115: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).
has alternative id: GO:0000396
has alternative id: GO:0000397
has broad synonym: 3'-splice site cleavage, exon ligation
has narrow synonym: U12-type spliceosome conformational change to release U4atac and U11
has narrow synonym: U2-type spliceosome conformational change to release U4 and U1
has narrow synonym: spliceosomal A1 complex biosynthesis
has narrow synonym: spliceosomal A1 complex formation
has narrow synonym: spliceosomal B2 complex biosynthesis
has narrow synonym: spliceosomal B2 complex formation
has OBO namespace: biological_process
id: GO:0000388
type: Class
comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian).
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: spliceosomal conformational changes to generate catalytic conformation

mRNA 3'-splice site recognition
IAO_0000115: Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.
has alternative id: GO:0000382
has alternative id: GO:0000383
has exact synonym: nuclear mRNA 3'-splice site recognition
has narrow synonym: U12-type nuclear mRNA 3'-splice site recognition
has narrow synonym: U2-type nuclear mRNA 3'-splice site recognition
has OBO namespace: biological_process
id: GO:0000389
type: Class
subclass of: GO_0006376

spliceosomal complex disassembly
IAO_0000115: Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.
has alternative id: GO:0000391
has alternative id: GO:0000392
has broad synonym: spliceosome disassembly
has exact synonym: spliceosome complex disassembly
has narrow synonym: U12-type spliceosome disassembly
has narrow synonym: U2-type spliceosome disassembly
has OBO namespace: biological_process
id: GO:0000390
type: Class
subclass of: GO_0032988
subclass of: Restriction
  on property: part_of
  some values from: mRNA splicing, via spliceosome

spliceosomal conformational changes to generate catalytic conformation
IAO_0000115: Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.
has broad synonym: 3'-splice site cleavage, exon ligation
has OBO namespace: biological_process
id: GO:0000393
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: mRNA splicing, via spliceosome

RNA splicing, via endonucleolytic cleavage and ligation
IAO_0000115: Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
has broad synonym: mRNA splicing
has OBO namespace: biological_process
id: GO:0000394
in subset: gosubset prok
type: Class
comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subclass of: GO_0008380

mRNA 5'-splice site recognition
IAO_0000115: Recognition of the intron 5'-splice site by components of the assembling spliceosome.
has alternative id: GO:0000368
has alternative id: GO:0000369
has exact synonym: nuclear mRNA 5' splice site recognition
has exact synonym: nuclear mRNA 5'-splice site recognition
has narrow synonym: U12-type nuclear mRNA 5' splice site recognition
has narrow synonym: U12-type nuclear mRNA 5'-splice site recognition
has narrow synonym: U2-type nuclear mRNA 5' splice site recognition
has narrow synonym: U2-type nuclear mRNA 5'-splice site recognition
has narrow synonym: spliceosomal CC complex biosynthesis
has narrow synonym: spliceosomal CC complex formation
has narrow synonym: spliceosomal E complex biosynthesis
has narrow synonym: spliceosomal E complex formation
has narrow synonym: spliceosomal commitment complex biosynthesis
has narrow synonym: spliceosomal commitment complex formation
has OBO namespace: biological_process
id: GO:0000395
type: Class
comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian).
subclass of: GO_0006376
subclass of: Restriction
  on property: part_of
  some values from: GO_0045292

mRNA splicing, via spliceosome
IAO_0000115: The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
has alternative id: GO:0006374
has alternative id: GO:0006375
has broad synonym: mRNA splicing
has broad synonym: pre-mRNA splicing
has db xref: Reactome:REACT_101135
has db xref: Reactome:REACT_101749
has db xref: Reactome:REACT_106268
has db xref: Reactome:REACT_107907
has db xref: Reactome:REACT_109091
has db xref: Reactome:REACT_112200
has db xref: Reactome:REACT_114266
has db xref: Reactome:REACT_114738
has db xref: Reactome:REACT_1753
has db xref: Reactome:REACT_30984
has db xref: Reactome:REACT_32449
has db xref: Reactome:REACT_34020
has db xref: Reactome:REACT_467
has db xref: Reactome:REACT_81417
has db xref: Reactome:REACT_82149
has db xref: Reactome:REACT_85452
has db xref: Reactome:REACT_86489
has db xref: Reactome:REACT_88186
has db xref: Reactome:REACT_89168
has db xref: Reactome:REACT_90296
has db xref: Reactome:REACT_91088
has db xref: Reactome:REACT_91611
has db xref: Reactome:REACT_91773
has db xref: Reactome:REACT_93740
has db xref: Reactome:REACT_93843
has db xref: Reactome:REACT_95764
has db xref: Reactome:REACT_99123
has db xref: Reactome:REACT_99763
has exact synonym: nuclear mRNA splicing, via spliceosome
has narrow synonym: nuclear mRNA splicing via U12-type spliceosome
has narrow synonym: nuclear mRNA splicing via U2-type spliceosome
has OBO namespace: biological_process
has related synonym: splicing AT-AC intron
has related synonym: splicing GT-AG intron
id: GO:0000398
type: Class
comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
subclass of: GO_0006397

cellular bud neck septin structure
IAO_0000115: Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle.
has OBO namespace: cellular_component
id: GO:0000399
type: Class
subclass of: GO_0032155
subclass of: Restriction
  on property: part_of
  some values from: GO_0005935

four-way junction DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
has broad synonym: forked DNA binding
has exact synonym: Holliday junction binding
has OBO namespace: molecular_function
id: GO:0000400
type: Class
subclass of: DNA secondary structure binding

open form four-way junction DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.
has exact synonym: open form Holliday junction binding
has OBO namespace: molecular_function
id: GO:0000401
type: Class
subclass of: four-way junction DNA binding

crossed form four-way junction DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands.
has exact synonym: crossed form Holliday junction binding
has OBO namespace: molecular_function
id: GO:0000402
type: Class
subclass of: four-way junction DNA binding

Y-form DNA binding
IAO_0000115: Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.
has broad synonym: forked DNA binding
has exact synonym: splayed Y-form DNA binding
has OBO namespace: molecular_function
id: GO:0000403
type: Class
subclass of: DNA secondary structure binding

loop DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.
has OBO namespace: molecular_function
id: GO:0000404
type: Class
subclass of: DNA secondary structure binding
subclass of: GO_0032135

bubble DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.
has OBO namespace: molecular_function
id: GO:0000405
type: Class
subclass of: DNA secondary structure binding

double-strand/single-strand DNA junction binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA.
has OBO namespace: molecular_function
id: GO:0000406
type: Class
subclass of: DNA secondary structure binding

pre-autophagosomal structure
IAO_0000115: A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.
has exact synonym: PAS
has narrow synonym: perivacuolar space
has OBO namespace: cellular_component
has related synonym: isolation membrane
has related synonym: phagophore
has related synonym: phagophore assembly site
id: GO:0000407
type: Class
subclass of: GO_0044444

EKC/KEOPS complex
IAO_0000115: A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
has exact synonym: Endopeptidase-like Kinase Chromatin-associated protein complex
has exact synonym: Kinase, putative Endopeptidase and Other Proteins of Small size protein complex
has OBO namespace: cellular_component
id: GO:0000408
type: Class
subclass of: GO_0043234
subclass of: GO_0044424

regulation of transcription by galactose
IAO_0000115: Any process involving galactose that modulates the frequency, rate or extent or transcription.
has OBO namespace: biological_process
id: GO:0000409
in subset: gosubset prok
type: Class
subclass of: GO_0045990

negative regulation of transcription by galactose
IAO_0000115: Any process involving galactose that stops, prevents or reduces the rate of transcription.
has exact synonym: down regulation of transcription by galactose
has exact synonym: down-regulation of transcription by galactose
has exact synonym: downregulation of transcription by galactose
has narrow synonym: inhibition of transcription by galactose
has OBO namespace: biological_process
id: GO:0000410
type: Class
subclass of: regulation of transcription by galactose
subclass of: GO_0045013

positive regulation of transcription by galactose
IAO_0000115: Any process involving galactose that activates or increases the rate of transcription.
has exact synonym: up regulation of transcription by galactose
has exact synonym: up-regulation of transcription by galactose
has exact synonym: upregulation of transcription by galactose
has narrow synonym: activation of transcription by galactose
has narrow synonym: stimulation of transcription by galactose
has OBO namespace: biological_process
id: GO:0000411
type: Class
subclass of: regulation of transcription by galactose
subclass of: GO_0045991

histone peptidyl-prolyl isomerization
IAO_0000115: The modification of a histone by cis-trans isomerization of a proline residue.
has exact synonym: histone proline isomerization
has OBO namespace: biological_process
id: GO:0000412
type: Class
subclass of: protein peptidyl-prolyl isomerization
subclass of: GO_0016570

protein peptidyl-prolyl isomerization
IAO_0000115: The modification of a protein by cis-trans isomerization of a proline residue.
has exact synonym: protein proline isomerization
has OBO namespace: biological_process
id: GO:0000413
type: Class
subclass of: GO_0018208

regulation of histone H3-K36 methylation
IAO_0000115: Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has OBO namespace: biological_process
id: GO:0000414
type: Class
subclass of: GO_0031060
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0010452

negative regulation of histone H3-K36 methylation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has exact synonym: down regulation of histone H3-K36 methylation
has exact synonym: down-regulation of histone H3-K36 methylation
has exact synonym: downregulation of histone H3-K36 methylation
has narrow synonym: inhibition of histone H3-K36 methylation
has OBO namespace: biological_process
id: GO:0000415
type: Class
subclass of: regulation of histone H3-K36 methylation
subclass of: GO_0031061
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0010452

positive regulation of histone H3-K36 methylation
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has exact synonym: up regulation of histone H3-K36 methylation
has exact synonym: up-regulation of histone H3-K36 methylation
has exact synonym: upregulation of histone H3-K36 methylation
has narrow synonym: activation of histone H3-K36 methylation
has narrow synonym: stimulation of histone H3-K36 methylation
has OBO namespace: biological_process
id: GO:0000416
type: Class
subclass of: regulation of histone H3-K36 methylation
subclass of: GO_0031062
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0010452

HIR complex
IAO_0000115: A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.
has exact synonym: HIRA complex
has OBO namespace: cellular_component
id: GO:0000417
type: Class
subclass of: GO_0005678

DNA-directed RNA polymerase IV complex
IAO_0000115: RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex.
has alternative id: GO:0000420
has exact synonym: DNA-directed RNA polymerase IVa complex
has OBO namespace: cellular_component
id: GO:0000418
type: Class
subclass of: GO_0044451
subclass of: GO_0055029

DNA-directed RNA polymerase V complex
IAO_0000115: RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits.
has alternative id: GO:0080137
has exact synonym: DNA-directed RNA polymerase IVb complex
has OBO namespace: cellular_component
id: GO:0000419
type: Class
subclass of: GO_0055029

autophagic vacuole membrane
IAO_0000115: The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
has exact synonym: autophagosome membrane
has OBO namespace: cellular_component
id: GO:0000421
type: Class
subclass of: GO_0005774
subclass of: Restriction
  on property: part_of
  some values from: GO_0005776

mitochondrion degradation
IAO_0000115: The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
has db xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy
has db xref: Wikipedia:Mitophagy
has exact synonym: mitophagy
has OBO namespace: biological_process
id: GO:0000422
type: Class
subclass of: GO_0006914

macromitophagy
IAO_0000115: Degradation of a mitochondrion by macroautophagy.
has OBO namespace: biological_process
id: GO:0000423
type: Class
subclass of: mitochondrion degradation
subclass of: GO_0016236

micromitophagy
IAO_0000115: Degradation of a mitochondrion by microautophagy.
has OBO namespace: biological_process
id: GO:0000424
type: Class
subclass of: mitochondrion degradation
subclass of: GO_0016237

macropexophagy
IAO_0000115: Degradation of a peroxisome by macropexophagy.
has OBO namespace: biological_process
id: GO:0000425
type: Class
subclass of: GO_0016236
subclass of: GO_0030242

micropexophagy
IAO_0000115: Degradation of a peroxisome by micropexophagy.
has OBO namespace: biological_process
id: GO:0000426
type: Class
subclass of: GO_0016237
subclass of: GO_0030242

plastid-encoded plastid RNA polymerase complex
IAO_0000115: An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition.
has OBO namespace: cellular_component
id: GO:0000427
type: Class
subclass of: DNA-directed RNA polymerase complex
subclass of: GO_0044435
subclass of: Restriction
  on property: part_of
  some values from: GO_0009536

DNA-directed RNA polymerase complex
IAO_0000115: A protein complex that possesses DNA-directed RNA polymerase activity.
has OBO namespace: cellular_component
id: GO:0000428
type: Class
subclass of: GO_0030880

carbon catabolite regulation of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
has exact synonym: regulation of transcription from RNA polymerase II promoter by carbon catabolites
has OBO namespace: biological_process
id: GO:0000429
type: Class
subclass of: GO_0006357
subclass of: GO_0045990

regulation of transcription from RNA polymerase II promoter by glucose
IAO_0000115: Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has OBO namespace: biological_process
id: GO:0000430
type: Class
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0046015

regulation of transcription from RNA polymerase II promoter by galactose
IAO_0000115: Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has OBO namespace: biological_process
id: GO:0000431
type: Class
subclass of: regulation of transcription by galactose
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter

positive regulation of transcription from RNA polymerase II promoter by glucose
IAO_0000115: Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
has exact synonym: up regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: up-regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: upregulation of transcription from RNA polymerase II promoter by glucose
has narrow synonym: activation of transcription from RNA polymerase II promoter by glucose
has narrow synonym: stimulation of transcription from RNA polymerase II promoter by glucose
has OBO namespace: biological_process
id: GO:0000432
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter by glucose
subclass of: carbon catabolite activation of transcription from RNA polymerase II promoter
subclass of: GO_0046016

negative regulation of transcription from RNA polymerase II promoter by glucose
IAO_0000115: Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
has exact synonym: down regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: down-regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: downregulation of transcription from RNA polymerase II promoter by glucose
has narrow synonym: inhibition of transcription from RNA polymerase II promoter by glucose
has OBO namespace: biological_process
id: GO:0000433
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter by glucose
subclass of: carbon catabolite repression of transcription from RNA polymerase II promoter
subclass of: GO_0045014

negative regulation of transcription from RNA polymerase II promoter by galactose
IAO_0000115: Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
has exact synonym: down regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: down-regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: downregulation of transcription from RNA polymerase II promoter by galactose
has narrow synonym: inhibition of transcription from RNA polymerase II promoter by galactose
has OBO namespace: biological_process
id: GO:0000434
type: Class
subclass of: negative regulation of transcription by galactose
subclass of: regulation of transcription from RNA polymerase II promoter by galactose
subclass of: carbon catabolite repression of transcription from RNA polymerase II promoter

positive regulation of transcription from RNA polymerase II promoter by galactose
IAO_0000115: Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
has exact synonym: up regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: up-regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: upregulation of transcription from RNA polymerase II promoter by galactose
has narrow synonym: activation of transcription from RNA polymerase II promoter by galactose
has narrow synonym: stimulation of transcription from RNA polymerase II promoter by galactose
has OBO namespace: biological_process
id: GO:0000435
type: Class
subclass of: positive regulation of transcription by galactose
subclass of: regulation of transcription from RNA polymerase II promoter by galactose
subclass of: carbon catabolite activation of transcription from RNA polymerase II promoter

carbon catabolite activation of transcription from RNA polymerase II promoter
IAO_0000115: Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has exact synonym: positive regulation of transcription from RNA polymerase II promoter by carbon catabolites
has OBO namespace: biological_process
id: GO:0000436
type: Class
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0045944
subclass of: GO_0045991

carbon catabolite repression of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
has exact synonym: negative regulation of transcription from RNA polymerase II promoter by carbon catabolites
has OBO namespace: biological_process
id: GO:0000437
type: Class
subclass of: negative regulation of transcription from RNA polymerase II promoter
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0045013

core TFIIH complex portion of holo TFIIH complex
IAO_0000115: The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.
has OBO namespace: cellular_component
id: GO:0000438
type: Class
subclass of: core TFIIH complex
subclass of: GO_0044451
subclass of: Restriction
  on property: part_of
  some values from: GO_0005675
subclass of: Restriction
  on property: part_of
  some values from: SSL2-core TFIIH complex portion of holo TFIIH complex

core TFIIH complex
IAO_0000115: The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34.
has OBO namespace: cellular_component
id: GO:0000439
type: Class
subclass of: GO_0032806
subclass of: Restriction
  on property: part_of
  some values from: SSL2-core TFIIH complex

core TFIIH complex portion of NEF3 complex
IAO_0000115: The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.
has OBO namespace: cellular_component
id: GO:0000440
type: Class
subclass of: core TFIIH complex
subclass of: Restriction
  on property: part_of
  some values from: nucleotide-excision repair factor 3 complex
subclass of: Restriction
  on property: part_of
  some values from: SSL2-core TFIIH complex portion of NEF3 complex

SSL2-core TFIIH complex
IAO_0000115: A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.
has OBO namespace: cellular_component
id: GO:0000441
in subset: goslim pir
type: Class
subclass of: GO_0043234

SSL2-core TFIIH complex portion of NEF3 complex
IAO_0000115: The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.
has OBO namespace: cellular_component
id: GO:0000442
type: Class
subclass of: SSL2-core TFIIH complex
subclass of: GO_0044428
subclass of: Restriction
  on property: part_of
  some values from: nucleotide-excision repair factor 3 complex

SSL2-core TFIIH complex portion of holo TFIIH complex
IAO_0000115: The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.
has OBO namespace: cellular_component
id: GO:0000443
type: Class
subclass of: SSL2-core TFIIH complex
subclass of: GO_0044451
subclass of: Restriction
  on property: part_of
  some values from: GO_0005675

MIS12/MIND type complex
IAO_0000115: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
has narrow synonym: Mis12 complex
has OBO namespace: cellular_component
id: GO:0000444
type: Class
subclass of: GO_0043234
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome kinetochore

THO complex part of transcription export complex
IAO_0000115: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
has exact synonym: THO complex part of TREX complex
has OBO namespace: cellular_component
id: GO:0000445
type: Class
subclass of: THO complex
subclass of: Restriction
  on property: part_of
  some values from: transcription export complex

nucleoplasmic THO complex
IAO_0000115: The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
has OBO namespace: cellular_component
id: GO:0000446
type: Class
subclass of: THO complex
subclass of: GO_0008023

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has narrow synonym: endonucleolytic cleavage at A2
has OBO namespace: biological_process
id: GO:0000447
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has alternative id: GO:0000490
has exact synonym: cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
has OBO namespace: biological_process
has related synonym: cleavage at C2
id: GO:0000448
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0000449
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species.
has OBO namespace: biological_process
id: GO:0000450
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

rRNA 2'-O-methylation
IAO_0000115: The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis.
has OBO namespace: biological_process
id: GO:0000451
type: Class
subclass of: GO_0031167

snoRNA guided rRNA 2'-O-methylation
IAO_0000115: The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation.
has OBO namespace: biological_process
has related synonym: snoRNA guided rRNA 2'-O-ribose methylation
id: GO:0000452
type: Class
subclass of: rRNA 2'-O-methylation

enzyme-directed rRNA 2'-O-methylation
IAO_0000115: The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA.
has OBO namespace: biological_process
id: GO:0000453
type: Class
subclass of: rRNA 2'-O-methylation

snoRNA guided rRNA pseudouridine synthesis
IAO_0000115: The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation.
has OBO namespace: biological_process
id: GO:0000454
type: Class
subclass of: GO_0031118

enzyme-directed rRNA pseudouridine synthesis
IAO_0000115: The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.
has OBO namespace: biological_process
id: GO:0000455
type: Class
subclass of: GO_0031118

dimethylation involved in SSU-rRNA maturation
IAO_0000115: Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes.
has OBO namespace: biological_process
id: GO:0000456
type: Class
subclass of: GO_0031167
subclass of: Restriction
  on property: part_of
  some values from: GO_0030490

endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
IAO_0000115: Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0000457
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
subclass of: Restriction
  on property: part_of
  some values from: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
IAO_0000115: Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0000458
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

exonucleolytic trimming involved in rRNA processing
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule.
has OBO namespace: biological_process
has related synonym: exonucleolytic trimming during rRNA processing
id: GO:0000459
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: GO_0090503
subclass of: Restriction
  on property: part_of
  some values from: GO_0006364

maturation of 5.8S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.
has OBO namespace: biological_process
id: GO:0000460
type: Class
subclass of: GO_0006364

endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
has narrow synonym: endonucleolytic cleavage at site D
has OBO namespace: biological_process
id: GO:0000461
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: GO_0031125
subclass of: Restriction
  on property: part_of
  some values from: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000462
type: Class
subclass of: GO_0030490

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000463
type: Class
subclass of: maturation of LSU-rRNA

endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.
has narrow synonym: endonucleolytic cleavage at A3
has OBO namespace: biological_process
id: GO:0000464
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000465
type: Class
subclass of: exonucleolytic trimming involved in rRNA processing
subclass of: rRNA 5'-end processing
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000466
type: Class
subclass of: maturation of 5.8S rRNA

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000467
type: Class
subclass of: exonucleolytic trimming involved in rRNA processing
subclass of: GO_0031125
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has narrow synonym: processing at B2
has OBO namespace: biological_process
id: GO:0000468
type: Class
subclass of: GO_0031125
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cleavage involved in rRNA processing
IAO_0000115: Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.
has OBO namespace: biological_process
has related synonym: cleavage during rRNA processing
id: GO:0000469
type: Class
subclass of: GO_0090501
subclass of: Restriction
  on property: part_of
  some values from: GO_0006364

maturation of LSU-rRNA
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.
has OBO namespace: biological_process
id: GO:0000470
type: Class
subclass of: GO_0006364
subclass of: Restriction
  on property: part_of
  some values from: GO_0042273

endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events.
has OBO namespace: biological_process
id: GO:0000471
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
has narrow synonym: endonucleolytic cleavage at A1
has OBO namespace: biological_process
id: GO:0000472
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: rRNA 5'-end processing
subclass of: Restriction
  on property: part_of
  some values from: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000473
type: Class
subclass of: maturation of LSU-rRNA

maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000474
type: Class
subclass of: GO_0030490

maturation of 2S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule.
has OBO namespace: biological_process
id: GO:0000475
type: Class
subclass of: GO_0006364

maturation of 4.5S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule.
has OBO namespace: biological_process
id: GO:0000476
type: Class
subclass of: GO_0006364

generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has narrow synonym: processing at C1
has OBO namespace: biological_process
id: GO:0000477
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: rRNA 5'-end processing
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA.
has OBO namespace: biological_process
has related synonym: endonucleolytic cleavage during rRNA processing
id: GO:0000478
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: GO_0090502
subclass of: Restriction
  on property: part_of
  some values from: GO_0006364

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.
has OBO namespace: biological_process
id: GO:0000479
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
has narrow synonym: endonucleolytic cleavage at A-prime
has narrow synonym: endonucleolytic cleavage at A0
has OBO namespace: biological_process
id: GO:0000480
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.
has OBO namespace: biological_process
id: GO:0000481
type: Class
subclass of: GO_0006364

maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000482
type: Class
subclass of: maturation of 5S rRNA

endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species.
has OBO namespace: biological_process
id: GO:0000483
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000484
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000485
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of 2S rRNA

cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000486
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: Restriction
  on property: part_of
  some values from: maturation of 2S rRNA
subclass of: Restriction
  on property: part_of
  some values from: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000487
type: Class
subclass of: maturation of 5.8S rRNA

maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000488
type: Class
subclass of: maturation of LSU-rRNA

maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0000489
type: Class
subclass of: GO_0030490

small nucleolar ribonucleoprotein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: snoRNP assembly
has OBO namespace: biological_process
id: GO:0000491
type: Class
subclass of: GO_0022618

box C/D snoRNP assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: box C/D small nucleolar ribonucleoprotein complex assembly
has OBO namespace: biological_process
id: GO:0000492
type: Class
subclass of: small nucleolar ribonucleoprotein complex assembly

box H/ACA snoRNP assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: box H/ACA small nucleolar ribonucleoprotein complex assembly
has OBO namespace: biological_process
id: GO:0000493
type: Class
subclass of: small nucleolar ribonucleoprotein complex assembly

box C/D snoRNA 3'-end processing
IAO_0000115: Any process involved in forming the mature 3' end of a box C/D snoRNA molecule.
has exact synonym: box C/D snoRNA 3' end processing
has OBO namespace: biological_process
id: GO:0000494
type: Class
subclass of: GO_0031126
subclass of: GO_0034963

box H/ACA snoRNA 3'-end processing
IAO_0000115: Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule.
has exact synonym: box H/ACA snoRNA 3' end processing
has OBO namespace: biological_process
id: GO:0000495
type: Class
subclass of: GO_0031126
subclass of: GO_0034964

base pairing
IAO_0000115: Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule.
has db xref: Wikipedia:Base_pair
has OBO namespace: molecular_function
id: GO:0000496
type: Class
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: nucleic acid binding

base pairing with DNA
IAO_0000115: Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule.
has OBO namespace: molecular_function
id: GO:0000497
type: Class
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: base pairing
subclass of: DNA binding

base pairing with RNA
IAO_0000115: Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule.
has OBO namespace: molecular_function
id: GO:0000498
type: Class
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: base pairing
subclass of: RNA binding

base pairing with mRNA
IAO_0000115: Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule.
has OBO namespace: molecular_function
id: GO:0000499
type: Class
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: base pairing with RNA

RNA polymerase I upstream activating factor complex
IAO_0000115: A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
has exact synonym: RNA polymerase I upstream activation factor complex
has exact synonym: UAF
has OBO namespace: cellular_component
id: GO:0000500
type: Class
subclass of: RNA polymerase I transcription factor complex

flocculation via cell wall protein-carbohydrate interaction
IAO_0000115: The non-sexual aggregation of cells mediated by protein (flocculin)-carbohydrate interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae.
has OBO namespace: biological_process
id: GO:0000501
in subset: gosubset prok
type: Class
subclass of: flocculation

proteasome complex
IAO_0000115: A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
has narrow synonym: 26S proteasome
has OBO namespace: cellular_component
id: GO:0000502
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044424

proteasome regulatory particle (sensu Bacteria)
IAO_0000115: OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
has narrow synonym: 26S proteasome
has OBO namespace: cellular_component
id: GO:0000504
type: Class
comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase.
deprecated: true

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
IAO_0000115: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.
has exact synonym: GPI-GlcNAc transferase complex
has exact synonym: GPI-GnT complex
has exact synonym: GPI-N-acetylglucosaminyltransferase complex
has OBO namespace: cellular_component
id: GO:0000506
type: Class
comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
subclass of: GO_0043234
subclass of: GO_0044432

embryonic axis specification
IAO_0000115: The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
has OBO namespace: biological_process
has related synonym: embryonic axis determination
id: GO:0000578
type: Class
subclass of: GO_0009798
subclass of: GO_0009880

mismatch base pair DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
has OBO namespace: molecular_function
id: GO:0000700
type: Class
subclass of: GO_0019104

purine-specific mismatch base pair DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
has db xref: EC:3.2.2.-
has narrow synonym: A/G-specific adenine DNA glycosylase activity
has OBO namespace: molecular_function
id: GO:0000701
type: Class
subclass of: mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
has OBO namespace: molecular_function
id: GO:0000702
in subset: gosubset prok
type: Class
subclass of: GO_0019104

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
has alternative id: GO:0019004
has broad synonym: DNA glycosylase/AP-lyase
has broad synonym: DNA glycosylase/beta-lyase
has broad synonym: bifunctional DNA glycosylase
has db xref: Reactome:REACT_101001
has db xref: Reactome:REACT_101090
has db xref: Reactome:REACT_101315
has db xref: Reactome:REACT_101744
has db xref: Reactome:REACT_102306
has db xref: Reactome:REACT_103688
has db xref: Reactome:REACT_103837
has db xref: Reactome:REACT_104179
has db xref: Reactome:REACT_104266
has db xref: Reactome:REACT_104313
has db xref: Reactome:REACT_105538
has db xref: Reactome:REACT_105622
has db xref: Reactome:REACT_105635
has db xref: Reactome:REACT_105967
has db xref: Reactome:REACT_106253
has db xref: Reactome:REACT_107207
has db xref: Reactome:REACT_107703
has db xref: Reactome:REACT_107763
has db xref: Reactome:REACT_108637
has db xref: Reactome:REACT_108860
has db xref: Reactome:REACT_109023
has db xref: Reactome:REACT_109743
has db xref: Reactome:REACT_2021
has db xref: Reactome:REACT_2157
has db xref: Reactome:REACT_2255
has db xref: Reactome:REACT_28127
has db xref: Reactome:REACT_28180
has db xref: Reactome:REACT_29323
has db xref: Reactome:REACT_29518
has db xref: Reactome:REACT_30621
has db xref: Reactome:REACT_30642
has db xref: Reactome:REACT_30750
has db xref: Reactome:REACT_32240
has db xref: Reactome:REACT_32421
has db xref: Reactome:REACT_32931
has db xref: Reactome:REACT_33078
has db xref: Reactome:REACT_33307
has db xref: Reactome:REACT_33417
has db xref: Reactome:REACT_33820
has db xref: Reactome:REACT_33839
has db xref: Reactome:REACT_33951
has db xref: Reactome:REACT_34296
has db xref: Reactome:REACT_77336
has db xref: Reactome:REACT_77526
has db xref: Reactome:REACT_78108
has db xref: Reactome:REACT_78298
has db xref: Reactome:REACT_78343
has db xref: Reactome:REACT_78458
has db xref: Reactome:REACT_78529
has db xref: Reactome:REACT_79663
has db xref: Reactome:REACT_79864
has db xref: Reactome:REACT_80155
has db xref: Reactome:REACT_81464
has db xref: Reactome:REACT_81531
has db xref: Reactome:REACT_82850
has db xref: Reactome:REACT_83701
has db xref: Reactome:REACT_83784
has db xref: Reactome:REACT_84042
has db xref: Reactome:REACT_84141
has db xref: Reactome:REACT_84471
has db xref: Reactome:REACT_85485
has db xref: Reactome:REACT_87055
has db xref: Reactome:REACT_87146
has db xref: Reactome:REACT_87389
has db xref: Reactome:REACT_87494
has db xref: Reactome:REACT_87850
has db xref: Reactome:REACT_87925
has db xref: Reactome:REACT_890
has db xref: Reactome:REACT_89137
has db xref: Reactome:REACT_89396
has db xref: Reactome:REACT_90163
has db xref: Reactome:REACT_90552
has db xref: Reactome:REACT_92193
has db xref: Reactome:REACT_92466
has db xref: Reactome:REACT_93244

pyrimidine dimer DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
has OBO namespace: molecular_function
id: GO:0000704
type: Class
subclass of: DNA-(apurinic or apyrimidinic site) lyase activity
subclass of: endodeoxyribonuclease activity
subclass of: GO_0019104

achiasmate meiosis I
IAO_0000115: The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata.
has OBO namespace: biological_process
id: GO:0000705
type: Class
subclass of: GO_0007127

meiotic DNA double-strand break processing
IAO_0000115: The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.
has OBO namespace: biological_process
id: GO:0000706
type: Class
subclass of: DNA double-strand break processing
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321

meiotic DNA recombinase assembly
IAO_0000115: During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.
has OBO namespace: biological_process
id: GO:0000707
type: Class
subclass of: DNA recombinase assembly
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321
subclass of: Restriction
  on property: part_of
  some values from: GO_0007127

meiotic strand invasion
IAO_0000115: The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis.
has OBO namespace: biological_process
has related synonym: meiotic D-loop biosynthesis
has related synonym: meiotic D-loop formation
has related synonym: meiotic displacement loop biosynthesis
has related synonym: meiotic displacement loop formation
id: GO:0000708
type: Class
subclass of: GO_0022402
subclass of: GO_0042148
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321
subclass of: Restriction
  on property: part_of
  some values from: GO_0007127

meiotic joint molecule formation
IAO_0000115: The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.
has OBO namespace: biological_process
id: GO:0000709
type: Class
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007131

meiotic mismatch repair
IAO_0000115: A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.
has OBO namespace: biological_process
id: GO:0000710
type: Class
subclass of: GO_0006298
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321
subclass of: Restriction
  on property: part_of
  some values from: GO_0007127

meiotic DNA repair synthesis
IAO_0000115: During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template.
has OBO namespace: biological_process
id: GO:0000711
type: Class
subclass of: DNA synthesis involved in DNA repair
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007127

resolution of meiotic recombination intermediates
IAO_0000115: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.
has exact synonym: homologous chromosome separation at meiosis I
has narrow synonym: crossover biosynthesis
has narrow synonym: crossover formation
has narrow synonym: formation of chiasmata
has narrow synonym: resolution of meiotic joint molecules as recombinants
has OBO namespace: biological_process
has related synonym: meiotic homologous chromosome separation
id: GO:0000712
type: Class
subclass of: GO_0051307
subclass of: Restriction
  on property: part_of
  some values from: GO_0007131

meiotic heteroduplex formation
IAO_0000115: During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.
has OBO namespace: biological_process
id: GO:0000713
type: Class
subclass of: GO_0022402
subclass of: GO_0030491
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321
subclass of: Restriction
  on property: part_of
  some values from: GO_0007127
subclass of: Restriction
  on property: part_of
  some values from: GO_0006310

meiotic strand displacement
IAO_0000115: The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis.
has OBO namespace: biological_process
has related synonym: meiotic D-loop dissociation
has related synonym: meiotic D-loop processing
has related synonym: meiotic displacement loop dissociation
has related synonym: meiotic displacement loop processing
id: GO:0000714
type: Class
subclass of: strand displacement
subclass of: GO_0022402
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007127
subclass of: Restriction
  on property: part_of
  some values from: GO_0051321

nucleotide-excision repair, DNA damage recognition
IAO_0000115: The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.
has db xref: Reactome:REACT_107456
has db xref: Reactome:REACT_112311
has db xref: Reactome:REACT_115249
has db xref: Reactome:REACT_115544
has db xref: Reactome:REACT_29640
has db xref: Reactome:REACT_30130
has db xref: Reactome:REACT_31764
has db xref: Reactome:REACT_476
has db xref: Reactome:REACT_77558
has db xref: Reactome:REACT_81184
has db xref: Reactome:REACT_82635
has db xref: Reactome:REACT_86796
has db xref: Reactome:REACT_89770
has db xref: Reactome:REACT_92224
has db xref: Reactome:REACT_94418
has db xref: Reactome:REACT_95988
has db xref: Reactome:REACT_97740
has db xref: Reactome:REACT_98000
has OBO namespace: biological_process
has related synonym: pyrimidine-dimer repair, DNA damage recognition
id: GO:0000715
in subset: gosubset prok
type: Class
subclass of: GO_0051276
subclass of: Restriction
  on property: part_of
  some values from: GO_0006289

transcription-coupled nucleotide-excision repair, DNA damage recognition
IAO_0000115: The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway.
has db xref: Reactome:REACT_100470
has db xref: Reactome:REACT_100673
has db xref: Reactome:REACT_100817
has db xref: Reactome:REACT_101583
has db xref: Reactome:REACT_103224
has db xref: Reactome:REACT_104426
has db xref: Reactome:REACT_106854
has db xref: Reactome:REACT_1947
has db xref: Reactome:REACT_78581
has db xref: Reactome:REACT_78888
has db xref: Reactome:REACT_80099
has db xref: Reactome:REACT_86060
has db xref: Reactome:REACT_86572
has db xref: Reactome:REACT_86848
has db xref: Reactome:REACT_88150
has db xref: Reactome:REACT_90318
has db xref: Reactome:REACT_96982
has OBO namespace: biological_process
has related synonym: pyrimidine-dimer repair, DNA damage recognition
id: GO:0000716
in subset: gosubset prok
type: Class
subclass of: nucleotide-excision repair, DNA damage recognition
subclass of: Restriction
  on property: part_of
  some values from: GO_0006283

nucleotide-excision repair, DNA duplex unwinding
IAO_0000115: The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.
has db xref: Reactome:REACT_101247
has db xref: Reactome:REACT_101644
has db xref: Reactome:REACT_1033
has db xref: Reactome:REACT_106346
has db xref: Reactome:REACT_107072
has db xref: Reactome:REACT_110827
has db xref: Reactome:REACT_113177
has db xref: Reactome:REACT_29217
has db xref: Reactome:REACT_34016
has db xref: Reactome:REACT_78462
has db xref: Reactome:REACT_81682
has db xref: Reactome:REACT_83794
has db xref: Reactome:REACT_84565
has db xref: Reactome:REACT_89030
has db xref: Reactome:REACT_95993
has db xref: Reactome:REACT_98302
has OBO namespace: biological_process
id: GO:0000717
in subset: gosubset prok
type: Class
subclass of: GO_0032508
subclass of: Restriction
  on property: part_of
  some values from: GO_0006289

nucleotide-excision repair, DNA damage removal
IAO_0000115: The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage.
has db xref: Reactome:REACT_102444
has db xref: Reactome:REACT_104645
has db xref: Reactome:REACT_109019
has db xref: Reactome:REACT_30192
has db xref: Reactome:REACT_311
has db xref: Reactome:REACT_31322
has db xref: Reactome:REACT_32014
has db xref: Reactome:REACT_52725
has db xref: Reactome:REACT_89200
has db xref: Reactome:REACT_90961
has db xref: Reactome:REACT_91383
has db xref: Reactome:REACT_92216
has db xref: Reactome:REACT_92900
has db xref: Reactome:REACT_93068
has db xref: Reactome:REACT_96787
has db xref: Reactome:REACT_99802
has OBO namespace: biological_process
id: GO:0000718
in subset: gosubset prok
type: Class
subclass of: GO_0006308
subclass of: GO_0044349
subclass of: Restriction
  on property: part_of
  some values from: GO_0006289

photoreactive repair
IAO_0000115: The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.
has narrow synonym: pyrimidine-dimer repair by photolyase
has OBO namespace: biological_process
id: GO:0000719
in subset: gosubset prok
type: Class
subclass of: GO_0006290

pyrimidine dimer repair by nucleotide-excision repair
IAO_0000115: The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
has OBO namespace: biological_process
id: GO:0000720
in subset: gosubset prok
type: Class
comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'.
subclass of: GO_0006289
subclass of: GO_0006290

(R,R)-butanediol dehydrogenase activity
IAO_0000115: Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+).
has db xref: EC:1.1.1.4
has db xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN
has db xref: RHEA:24343
has exact synonym: (R)-2,3-butanediol dehydrogenase activity
has exact synonym: (R)-diacetyl reductase activity
has exact synonym: 1-amino-2-propanol dehydrogenase activity
has exact synonym: 1-amino-2-propanol oxidoreductase activity
has exact synonym: 2,3-butanediol dehydrogenase activity
has exact synonym: D-(-)-butanediol dehydrogenase activity
has exact synonym: D-1-amino-2-propanol dehydrogenase activity
has exact synonym: D-1-amino-2-propanol:NAD(2) oxidoreductase activity
has exact synonym: D-aminopropanol dehydrogenase activity
has exact synonym: D-butanediol dehydrogenase activity
has exact synonym: aminopropanol oxidoreductase activity
has exact synonym: butylene glycol dehydrogenase activity
has exact synonym: butyleneglycol dehydrogenase activity
has OBO namespace: molecular_function
has related synonym: diacetyl (acetoin) reductase activity
id: GO:0000721
in subset: gosubset prok
type: Class
subclass of: GO_0016616

telomere maintenance via recombination
IAO_0000115: Any recombinational process that contributes to the maintenance of proper telomeric length.
has db xref: Reactome:REACT_101373
has db xref: Reactome:REACT_101439
has db xref: Reactome:REACT_101498
has db xref: Reactome:REACT_101756
has db xref: Reactome:REACT_101953
has db xref: Reactome:REACT_102170
has db xref: Reactome:REACT_102248
has db xref: Reactome:REACT_102860
has db xref: Reactome:REACT_102881
has db xref: Reactome:REACT_103207
has db xref: Reactome:REACT_103350
has db xref: Reactome:REACT_103501
has db xref: Reactome:REACT_103857
has db xref: Reactome:REACT_104171
has db xref: Reactome:REACT_104453
has db xref: Reactome:REACT_104638
has db xref: Reactome:REACT_104914
has db xref: Reactome:REACT_105177
has db xref: Reactome:REACT_105258
has db xref: Reactome:REACT_105462
has db xref: Reactome:REACT_105491
has db xref: Reactome:REACT_106206
has db xref: Reactome:REACT_106874
has db xref: Reactome:REACT_106919
has db xref: Reactome:REACT_106924
has db xref: Reactome:REACT_106994
has db xref: Reactome:REACT_107163
has db xref: Reactome:REACT_107299
has db xref: Reactome:REACT_107682
has db xref: Reactome:REACT_108058
has db xref: Reactome:REACT_108279
has db xref: Reactome:REACT_108285
has db xref: Reactome:REACT_108323
has db xref: Reactome:REACT_108876
has db xref: Reactome:REACT_109084
has db xref: Reactome:REACT_109593
has db xref: Reactome:REACT_109676
has db xref: Reactome:REACT_110206
has db xref: Reactome:REACT_110252
has db xref: Reactome:REACT_110586
has db xref: Reactome:REACT_110741
has db xref: Reactome:REACT_28103
has db xref: Reactome:REACT_28301
has db xref: Reactome:REACT_28337
has db xref: Reactome:REACT_28438
has db xref: Reactome:REACT_28735
has db xref: Reactome:REACT_28845
has db xref: Reactome:REACT_29030
has db xref: Reactome:REACT_29091
has db xref: Reactome:REACT_29268
has db xref: Reactome:REACT_29498
has db xref: Reactome:REACT_29561
has db xref: Reactome:REACT_29730
has db xref: Reactome:REACT_29736
has db xref: Reactome:REACT_30132
has db xref: Reactome:REACT_30146
has db xref: Reactome:REACT_30357
has db xref: Reactome:REACT_30676
has db xref: Reactome:REACT_31415
has db xref: Reactome:REACT_31855
has db xref: Reactome:REACT_31896
has db xref: Reactome:REACT_32409
has db xref: Reactome:REACT_32656
has db xref: Reactome:REACT_32714
has db xref: Reactome:REACT_32801
has db xref: Reactome:REACT_33015
has db xref: Reactome:REACT_33071
has db xref: Reactome:REACT_33514
has db xref: Reactome:REACT_33663
has db xref: Reactome:REACT_33974
has db xref: Reactome:REACT_34757
has db xref: Reactome:REACT_57279
has db xref: Reactome:REACT_77128
has db xref: Reactome:REACT_77820
has db xref: Reactome:REACT_77906
has db xref: Reactome:REACT_77925
has db xref: Reactome:REACT_78056
has db xref: Reactome:REACT_78182
has db xref: Reactome:REACT_78501

telomere maintenance
IAO_0000115: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences.
has db xref: Reactome:REACT_102051
has db xref: Reactome:REACT_102166
has db xref: Reactome:REACT_103257
has db xref: Reactome:REACT_103618
has db xref: Reactome:REACT_104398
has db xref: Reactome:REACT_105276
has db xref: Reactome:REACT_105401
has db xref: Reactome:REACT_105641
has db xref: Reactome:REACT_107344
has db xref: Reactome:REACT_109055
has db xref: Reactome:REACT_110319
has db xref: Reactome:REACT_115102
has db xref: Reactome:REACT_115503
has db xref: Reactome:REACT_115535
has db xref: Reactome:REACT_31996
has db xref: Reactome:REACT_32322
has db xref: Reactome:REACT_78001
has db xref: Reactome:REACT_78680
has db xref: Reactome:REACT_7954
has db xref: Reactome:REACT_7963
has db xref: Reactome:REACT_7970
has db xref: Reactome:REACT_80940
has db xref: Reactome:REACT_82431
has db xref: Reactome:REACT_83277
has db xref: Reactome:REACT_84888
has db xref: Reactome:REACT_85317
has db xref: Reactome:REACT_85782
has db xref: Reactome:REACT_86038
has db xref: Reactome:REACT_86194
has db xref: Reactome:REACT_87184
has db xref: Reactome:REACT_88530
has db xref: Reactome:REACT_94176
has db xref: Reactome:REACT_94707
has db xref: Reactome:REACT_96013
has db xref: Reactome:REACT_96166
has OBO namespace: biological_process
has related synonym: regulation of telomere length
id: GO:0000723
type: Class
subclass of: GO_0006259
subclass of: GO_0032200
subclass of: GO_0060249

double-strand break repair via homologous recombination
IAO_0000115: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
has alternative id: GO:0016924
has db xref: Reactome:REACT_103005
has db xref: Reactome:REACT_108237
has db xref: Reactome:REACT_115539
has db xref: Reactome:REACT_115585
has db xref: Reactome:REACT_115626
has db xref: Reactome:REACT_115651
has db xref: Reactome:REACT_115715
has db xref: Reactome:REACT_115769
has db xref: Reactome:REACT_115931
has db xref: Reactome:REACT_115936
has db xref: Reactome:REACT_1874
has db xref: Reactome:REACT_29815
has db xref: Reactome:REACT_33853
has db xref: Reactome:REACT_42307
has db xref: Reactome:REACT_80576
has db xref: Reactome:REACT_82771
has db xref: Reactome:REACT_83941
has db xref: Reactome:REACT_84594
has db xref: Reactome:REACT_84793
has db xref: Reactome:REACT_85965
has db xref: Reactome:REACT_87979
has db xref: Reactome:REACT_90944
has db xref: Reactome:REACT_92384
has db xref: Reactome:REACT_92897
has db xref: Reactome:REACT_97339
has db xref: Reactome:REACT_99066
has db xref: Reactome:REACT_99423
has exact synonym: HDR
has exact synonym: HRR
has exact synonym: Rad51-dependent recombinational repair
has exact synonym: Rhp51-dependent recombinational repair
has exact synonym: homologous recombinational repair
has exact synonym: homology-directed repair
has OBO namespace: biological_process
id: GO:0000724
in subset: gosubset prok
type: Class
subclass of: recombinational repair
subclass of: GO_0006302

recombinational repair
IAO_0000115: A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.
has db xref: Wikipedia:Recombinational_repair
has OBO namespace: biological_process
id: GO:0000725
in subset: gosubset prok
type: Class
subclass of: GO_0006281
subclass of: GO_0006310

non-recombinational repair
IAO_0000115: A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA.
has OBO namespace: biological_process
id: GO:0000726
in subset: gosubset prok
type: Class
subclass of: GO_0006281

double-strand break repair via break-induced replication
IAO_0000115: The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
has OBO namespace: biological_process
id: GO:0000727
in subset: gosubset prok
type: Class
subclass of: double-strand break repair via homologous recombination

gene conversion at mating-type locus, DNA double-strand break formation
IAO_0000115: The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another.
has OBO namespace: biological_process
id: GO:0000728
type: Class
subclass of: GO_0048610
subclass of: GO_0090305
subclass of: Restriction
  on property: part_of
  some values from: GO_0007534

DNA double-strand break processing
IAO_0000115: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.
has db xref: Reactome:REACT_172
has OBO namespace: biological_process
id: GO:0000729
type: Class
subclass of: DNA catabolic process, exonucleolytic
subclass of: Restriction
  on property: part_of
  some values from: GO_0006302

DNA recombinase assembly
IAO_0000115: The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.
has db xref: Reactome:REACT_100225
has db xref: Reactome:REACT_100616
has db xref: Reactome:REACT_101062
has db xref: Reactome:REACT_102016
has db xref: Reactome:REACT_103788
has db xref: Reactome:REACT_104366
has db xref: Reactome:REACT_106498
has db xref: Reactome:REACT_110494
has db xref: Reactome:REACT_2141
has db xref: Reactome:REACT_28107
has db xref: Reactome:REACT_32257
has db xref: Reactome:REACT_78586
has db xref: Reactome:REACT_79561
has db xref: Reactome:REACT_81810
has db xref: Reactome:REACT_82066
has db xref: Reactome:REACT_85201
has db xref: Reactome:REACT_88197
has db xref: Reactome:REACT_96901
has exact synonym: Rad51 nucleoprotein filament formation
has OBO namespace: biological_process
id: GO:0000730
type: Class
subclass of: GO_0065004
subclass of: Restriction
  on property: part_of
  some values from: GO_0045003

DNA synthesis involved in DNA repair
IAO_0000115: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.
has broad synonym: DNA repair synthesis
has db xref: Reactome:REACT_973
has narrow synonym: mitotic DNA repair synthesis
has OBO namespace: biological_process
has related synonym: DNA synthesis during DNA repair
id: GO:0000731
in subset: gosubset prok
type: Class
subclass of: GO_0071897
subclass of: Restriction
  on property: part_of
  some values from: GO_0006281

strand displacement
IAO_0000115: The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.
has db xref: Reactome:REACT_287
has OBO namespace: biological_process
has related synonym: D-loop dissociation
has related synonym: D-loop processing
has related synonym: displacement loop dissociation
has related synonym: displacement loop processing
id: GO:0000732
in subset: gosubset prok
type: Class
subclass of: GO_0006259
subclass of: Restriction
  on property: part_of
  some values from: GO_0006310

DNA strand renaturation
IAO_0000115: The identification and annealing of complementary base pairs in single-strand DNA.
has OBO namespace: biological_process
id: GO:0000733
in subset: gosubset prok
type: Class
subclass of: GO_0006259

gene conversion at mating-type locus, DNA repair synthesis
IAO_0000115: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus.
has OBO namespace: biological_process
id: GO:0000734
type: Class
subclass of: DNA synthesis involved in DNA repair
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007534

removal of nonhomologous ends
IAO_0000115: The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.
has OBO namespace: biological_process
id: GO:0000735
type: Class
subclass of: DNA catabolic process, endonucleolytic
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0007534

double-strand break repair via single-strand annealing, removal of nonhomologous ends
IAO_0000115: During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.
has OBO namespace: biological_process
id: GO:0000736
in subset: gosubset prok
type: Class
subclass of: removal of nonhomologous ends
subclass of: Restriction
  on property: part_of
  some values from: GO_0045002

DNA catabolic process, endonucleolytic
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has exact synonym: DNA breakdown, endonucleolytic
has exact synonym: DNA degradation, endonucleolytic
has exact synonym: endonucleolytic DNA catabolism
has exact synonym: endonucleolytic degradation of DNA
has OBO namespace: biological_process
id: GO:0000737
in subset: gosubset prok
type: Class
subclass of: GO_0006308
subclass of: GO_0090305

DNA catabolic process, exonucleolytic
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has exact synonym: DNA breakdown, exonucleolytic
has exact synonym: DNA degradation, exonucleolytic
has exact synonym: exonucleolytic degradation of DNA
has OBO namespace: biological_process
id: GO:0000738
in subset: gosubset prok
type: Class
subclass of: GO_0006308
subclass of: GO_0090305

DNA strand annealing activity
IAO_0000115: OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA.
consider: GO:0000733
consider: GO:0036292
consider: GO:0036310
has OBO namespace: molecular_function
id: GO:0000739
type: Class
comment: This term was made obsolete because it describes a process and not an activity.
deprecated: true

nuclear membrane fusion
IAO_0000115: The joining of 2 or more lipid bilayer membranes that surround the nucleus.
has OBO namespace: biological_process
id: GO:0000740
type: Class
subclass of: GO_0090174

karyogamy
IAO_0000115: The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.
has alternative id: GO:0007335
has db xref: Wikipedia:Karyogamy
has exact synonym: nuclear fusion
has exact synonym: nuclear fusion during karyogamy
has OBO namespace: biological_process
id: GO:0000741
type: Class
subclass of: GO_0048284
subclass of: Restriction
  on property: part_of
  some values from: GO_0006997

karyogamy involved in conjugation with cellular fusion
IAO_0000115: During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.
has OBO namespace: biological_process
has related synonym: karyogamy during conjugation with cellular fusion
id: GO:0000742
type: Class
subclass of: karyogamy
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: conjugation with cellular fusion

nuclear migration involved in conjugation with cellular fusion
IAO_0000115: The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion.
has alternative id: GO:0006946
has broad synonym: nuclear congression
has OBO namespace: biological_process
has related synonym: nuclear migration during conjugation with cellular fusion
id: GO:0000743
type: Class
subclass of: GO_0030473
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: conjugation with cellular fusion

karyogamy involved in conjugation with mutual genetic exchange
IAO_0000115: During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei.
has exact synonym: karyogamy involved in conjugation without cellular fusion
has OBO namespace: biological_process
id: GO:0000744
type: Class
subclass of: karyogamy
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange

nuclear migration involved in conjugation with mutual genetic exchange
IAO_0000115: The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion.
has exact synonym: nuclear migration involved in conjugation without cellular fusion
has OBO namespace: biological_process
has related synonym: nuclear exchange during conjugation without cellular fusion
id: GO:0000745
type: Class
subclass of: GO_0007097
subclass of: Restriction
  on property: part_of
  some values from: karyogamy involved in conjugation with mutual genetic exchange
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange

conjugation
IAO_0000115: The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms.
has db xref: Wikipedia:Conjugation
has OBO namespace: biological_process
id: GO:0000746
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim yeast
in subset: gosubset prok
type: Class
subclass of: GO_0044764

conjugation with cellular fusion
IAO_0000115: A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
has alternative id: GO:0007322
has alternative id: GO:0007333
has alternative id: GO:0030461
has alternative id: GO:0030477
has OBO namespace: biological_process
has related synonym: cell fusion
has related synonym: mating
id: GO:0000747
in subset: goslim pombe
type: Class
subclass of: conjugation
subclass of: GO_0019953

conjugation with mutual genetic exchange
IAO_0000115: A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange.
has exact synonym: conjugation without cellular fusion
has OBO namespace: biological_process
id: GO:0000748
type: Class
subclass of: conjugation

response to pheromone involved in conjugation with cellular fusion
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
has alternative id: GO:0007328
has alternative id: GO:0030434
has OBO namespace: biological_process
has related synonym: response to pheromone during conjugation with cellular fusion
id: GO:0000749
type: Class
subclass of: GO_0048610
subclass of: GO_0071444
subclass of: Restriction
  on property: part_of
  some values from: conjugation with cellular fusion

pheromone-dependent signal transduction involved in conjugation with cellular fusion
IAO_0000115: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
has alternative id: GO:0007330
has alternative id: GO:0030454
has broad synonym: transduction of mating signal
has OBO namespace: biological_process
id: GO:0000750
type: Class
subclass of: GO_0007186
subclass of: GO_0032005
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with cellular fusion

cell cycle arrest in response to pheromone
IAO_0000115: The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae.
has alternative id: GO:0030571
has OBO namespace: biological_process
id: GO:0000751
type: Class
subclass of: GO_0007050
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with cellular fusion

agglutination involved in conjugation with cellular fusion
IAO_0000115: During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae.
has alternative id: GO:0007334
has broad synonym: agglutination
has exact synonym: cell-cell adhesion during conjugation with cellular fusion
has exact synonym: cell-cell adhesion during mating
has OBO namespace: biological_process
id: GO:0000752
type: Class
subclass of: agglutination involved in conjugation
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with cellular fusion
subclass of: Restriction
  on property: part_of
  some values from: conjugation with cellular fusion

cell morphogenesis involved in conjugation with cellular fusion
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion.
has alternative id: GO:0007332
has narrow synonym: shmoo orientation
has narrow synonym: shmooing
has OBO namespace: biological_process
id: GO:0000753
type: Class
subclass of: cell morphogenesis involved in conjugation
subclass of: developmental process involved in reproduction
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: conjugation with cellular fusion
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with cellular fusion

adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
IAO_0000115: In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
has alternative id: GO:0007331
has alternative id: GO:0030453
has exact synonym: adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion
has exact synonym: desensitization to pheromone during conjugation with cellular fusion
has OBO namespace: biological_process
has related synonym: adaptation to pheromone during conjugation with cellular fusion
id: GO:0000754
type: Class
subclass of: response to pheromone involved in conjugation with cellular fusion
subclass of: GO_0023058

cytogamy
IAO_0000115: During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
has alternative id: GO:0000218
has alternative id: GO:0030462
has OBO namespace: biological_process
has related synonym: zygote formation
id: GO:0000755
type: Class
subclass of: GO_0022413
subclass of: Restriction
  on property: part_of
  some values from: conjugation with cellular fusion

response to pheromone involved in conjugation with mutual genetic exchange
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion.
has exact synonym: response to pheromone involved in conjugation without cellular fusion
has OBO namespace: biological_process
id: GO:0000756
type: Class
subclass of: GO_0007154
subclass of: GO_0071444
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange

signal transduction involved in conjugation with mutual genetic exchange
IAO_0000115: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion.
has exact synonym: signal transduction involved in conjugation without cellular fusion
has OBO namespace: biological_process
id: GO:0000757
type: Class
subclass of: GO_0007186
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with mutual genetic exchange

agglutination involved in conjugation with mutual genetic exchange
IAO_0000115: During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions.
has exact synonym: agglutination involved in conjugation without cellular fusion
has OBO namespace: biological_process
id: GO:0000758
type: Class
subclass of: agglutination involved in conjugation
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with mutual genetic exchange
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange

cell morphogenesis involved in conjugation with mutual genetic exchange
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion.
has exact synonym: cellular morphogenesis involved in conjugation without cellular fusion
has OBO namespace: biological_process
id: GO:0000759
type: Class
subclass of: cell morphogenesis involved in conjugation
subclass of: Restriction
  on property: part_of
  some values from: response to pheromone involved in conjugation with mutual genetic exchange
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange

adaptation to pheromone involved in conjugation with mutual genetic exchange
IAO_0000115: In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses.
has exact synonym: desensitization to pheromone during conjugation without cellular fusion
has OBO namespace: biological_process
has related synonym: adaptation to pheromone involved conjugation without cellular fusion
id: GO:0000760
type: Class
subclass of: response to pheromone involved in conjugation with mutual genetic exchange
subclass of: GO_0022401

conjugant formation
IAO_0000115: During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing.
has OBO namespace: biological_process
id: GO:0000761
type: Class
subclass of: GO_0016337
subclass of: Restriction
  on property: part_of
  some values from: conjugation with mutual genetic exchange

pheromone-induced unidirectional conjugation
IAO_0000115: The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types.
has OBO namespace: biological_process
id: GO:0000762
type: Class
subclass of: GO_0009291

cell morphogenesis involved in unidirectional conjugation
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation.
has OBO namespace: biological_process
id: GO:0000763
type: Class
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
deprecated: true

cellular morphogenesis involved in pheromone-induced unidirectional conjugation
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation.
has OBO namespace: biological_process
has related synonym: cellular morphogenesis during pheromone-induced unidirectional
id: GO:0000764
type: Class
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
deprecated: true

response to pheromone involved in pheromone-induced unidirectional conjugation
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation.
has OBO namespace: biological_process
has related synonym: response to pheromone during pheromone-induced unidirectional
id: GO:0000765
type: Class
subclass of: GO_0019236
subclass of: Restriction
  on property: part_of
  some values from: pheromone-induced unidirectional conjugation

negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
IAO_0000115: In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses.
has exact synonym: desensitization to pheromone during pheromone-induced unidirectional conjugation
has exact synonym: negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
has OBO namespace: biological_process
has related synonym: adaptation to pheromone during pheromone-induced unidirectional conjugation
id: GO:0000766
type: Class
subclass of: response to pheromone involved in pheromone-induced unidirectional conjugation
subclass of: GO_0022401

cell morphogenesis involved in conjugation
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types.
has OBO namespace: biological_process
id: GO:0000767
type: Class
subclass of: cell morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: conjugation

syncytium formation by plasma membrane fusion
IAO_0000115: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
has broad synonym: cell fusion
has exact synonym: cell-cell fusion
has OBO namespace: biological_process
id: GO:0000768
type: Class
subclass of: GO_0006949

syncytium formation by mitosis without cytokinesis
IAO_0000115: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis.
has OBO namespace: biological_process
has related synonym: syncytium formation by mitosis without cell division
id: GO:0000769
type: Class
subclass of: GO_0006949

peptide pheromone export
IAO_0000115: The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones.
has alternative id: GO:0007325
has exact synonym: peptide pheromone secretion
has narrow synonym: a-factor export
has OBO namespace: biological_process
id: GO:0000770
type: Class
subclass of: GO_0030072

agglutination involved in conjugation
IAO_0000115: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation.
has OBO namespace: biological_process
id: GO:0000771
type: Class
subclass of: GO_0007157
subclass of: Restriction
  on property: part_of
  some values from: conjugation

mating pheromone activity
IAO_0000115: The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.
has OBO namespace: molecular_function
id: GO:0000772
type: Class
subclass of: GO_0005186

phosphatidyl-N-methylethanolamine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
has db xref: EC:2.1.1.71
has db xref: MetaCyc:2.1.1.71-RXN
has exact synonym: PLMT
has exact synonym: S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity
has exact synonym: phosphatidyl-N-methylethanolamine methyltransferase activity
has exact synonym: phosphatidyl-N-monomethylethanolamine methyltransferase activity
has exact synonym: phosphatidylmonomethylethanolamine methyltransferase activity
has exact synonym: phospholipid methyltransferase activity
has OBO namespace: molecular_function
has related synonym: methyltransferase II
has related synonym: phosphatidylethanolamine methyltransferase I
id: GO:0000773
in subset: gosubset prok
type: Class
subclass of: GO_0008170
subclass of: GO_0008757

adenyl-nucleotide exchange factor activity
IAO_0000115: Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
has OBO namespace: molecular_function
id: GO:0000774
in subset: gosubset prok
type: Class
subclass of: GO_0030554
subclass of: GO_0060590

chromosome, centromeric region
IAO_0000115: The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: chromosome, centric region
has OBO namespace: cellular_component
has related synonym: centromere
has related synonym: chromosome, pericentric region
id: GO:0000775
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
subclass of: GO_0044427

kinetochore
IAO_0000115: A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
has alternative id: GO:0005699
has db xref: Wikipedia:Kinetochore
has OBO namespace: cellular_component
id: GO:0000776
in subset: goslim pir
type: Class
comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore.
subclass of: GO_0043232
subclass of: GO_0043234
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: chromosome, centromeric region

condensed chromosome kinetochore
IAO_0000115: A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
has OBO namespace: cellular_component
id: GO:0000777
type: Class
subclass of: kinetochore
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome, centromeric region
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome

condensed nuclear chromosome kinetochore
IAO_0000115: A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules.
has OBO namespace: cellular_component
id: GO:0000778
type: Class
subclass of: condensed chromosome kinetochore
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome, centromeric region

condensed chromosome, centromeric region
IAO_0000115: The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: condensed chromosome, centric region
has OBO namespace: cellular_component
has related synonym: condensed chromosome, centromere
has related synonym: condensed chromosome, pericentric region
id: GO:0000779
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
subclass of: chromosome, centromeric region
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome

condensed nuclear chromosome, centromeric region
IAO_0000115: The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: condensed nuclear chromosome, centric region
has OBO namespace: cellular_component
has related synonym: condensed nuclear chromosome, centromere
has related synonym: condensed nuclear chromosome, pericentric region
id: GO:0000780
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
subclass of: condensed chromosome, centromeric region
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

chromosome, telomeric region
IAO_0000115: The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
has OBO namespace: cellular_component
has related synonym: telomere
id: GO:0000781
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
subclass of: GO_0044427

telomere cap complex
IAO_0000115: A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.
has OBO namespace: cellular_component
id: GO:0000782
in subset: goslim pir
in subset: gosubset prok
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subclass of: GO_0032993
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: chromosome, telomeric region

nuclear telomere cap complex
IAO_0000115: A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
has OBO namespace: cellular_component
id: GO:0000783
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subclass of: telomere cap complex
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: nuclear chromosome, telomeric region
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

nuclear chromosome, telomeric region
IAO_0000115: The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins.
has exact synonym: nuclear chromosome, telomere
has OBO namespace: cellular_component
id: GO:0000784
type: Class
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
subclass of: chromosome, telomeric region
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

chromatin
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
has alternative id: GO:0005717
has db xref: NIF_Subcellular:sao1615953555
has OBO namespace: cellular_component
has related synonym: chromosome scaffold
id: GO:0000785
type: Class
subclass of: GO_0044427

nucleosome
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
has alternative id: GO:0005718
has db xref: Wikipedia:Nucleosome
has OBO namespace: cellular_component
id: GO:0000786
in subset: goslim pir
type: Class
subclass of: GO_0032993
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: chromatin

cytoplasmic nucleosome
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures.
has OBO namespace: cellular_component
id: GO:0000787
type: Class
subclass of: nucleosome
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic chromatin

nuclear nucleosome
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
has OBO namespace: cellular_component
id: GO:0000788
type: Class
subclass of: nucleosome
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634
subclass of: Restriction
  on property: part_of
  some values from: nuclear chromatin

cytoplasmic chromatin
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm.
has OBO namespace: cellular_component
id: GO:0000789
type: Class
subclass of: chromatin
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic chromosome

nuclear chromatin
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
has OBO namespace: cellular_component
id: GO:0000790
type: Class
subclass of: chromatin
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

euchromatin
IAO_0000115: A dispersed and relatively uncompacted form of chromatin.
has db xref: NIF_Subcellular:sao445485807
has db xref: Wikipedia:Euchromatin
has OBO namespace: cellular_component
id: GO:0000791
type: Class
subclass of: chromatin

heterochromatin
IAO_0000115: A compact and highly condensed form of chromatin.
has db xref: NIF_Subcellular:sao581845896
has db xref: Wikipedia:Heterochromatin
has OBO namespace: cellular_component
id: GO:0000792
type: Class
subclass of: chromatin

condensed chromosome
IAO_0000115: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
has OBO namespace: cellular_component
has related synonym: cytoplasmic mitotic chromosome
has related synonym: metaphase chromosome
has related synonym: mitotic chromosome
id: GO:0000793
type: Class
comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
subclass of: GO_0005694

condensed nuclear chromosome
IAO_0000115: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.
has OBO namespace: cellular_component
has related synonym: meiotic chromosome
has related synonym: nuclear mitotic chromosome
id: GO:0000794
type: Class
comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
subclass of: nuclear chromosome
subclass of: condensed chromosome
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

synaptonemal complex
IAO_0000115: A proteinaceous scaffold found between homologous chromosomes during meiosis.
has alternative id: GO:0005716
has db xref: Wikipedia:Synaptonemal_complex
has OBO namespace: cellular_component
id: GO:0000795
type: Class
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome

condensin complex
IAO_0000115: A multisubunit protein complex that plays a central role in chromosome condensation.
has alternative id: GO:0005676
has alternative id: GO:0008620
has narrow synonym: 13S condensin complex
has OBO namespace: cellular_component
has related synonym: SMC complex
id: GO:0000796
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome

condensin core heterodimer
IAO_0000115: The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation.
has alternative id: GO:0008621
has narrow synonym: 8S condensin complex
has narrow synonym: Smc2-Smc4 complex
has OBO namespace: cellular_component
id: GO:0000797
type: Class
subclass of: GO_0043234
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: condensin complex

nuclear cohesin complex
IAO_0000115: A cohesin complex required for cohesion between sister chromatids that remain in the nucleus.
has OBO namespace: cellular_component
id: GO:0000798
type: Class
comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
subclass of: GO_0008278
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome

nuclear condensin complex
IAO_0000115: A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus.
has OBO namespace: cellular_component
id: GO:0000799
type: Class
subclass of: condensin complex
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634

lateral element
IAO_0000115: A proteinaceous core found between sister chromatids during meiotic prophase.
has exact synonym: axial element
has OBO namespace: cellular_component
id: GO:0000800
type: Class
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: synaptonemal complex

central element
IAO_0000115: A structural unit of the synaptonemal complex found between the lateral elements.
has OBO namespace: cellular_component
id: GO:0000801
type: Class
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: synaptonemal complex

transverse filament
IAO_0000115: A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.
has OBO namespace: cellular_component
id: GO:0000802
type: Class
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: synaptonemal complex

sex chromosome
IAO_0000115: A chromosome involved in sex determination.
has OBO namespace: cellular_component
id: GO:0000803
type: Class
subclass of: GO_0005694

W chromosome
IAO_0000115: The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females.
has db xref: Wikipedia:ZW_sex-determination_system
has OBO namespace: cellular_component
id: GO:0000804
type: Class
subclass of: sex chromosome

X chromosome
IAO_0000115: The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.
has db xref: Wikipedia:X_chromosome
has OBO namespace: cellular_component
id: GO:0000805
type: Class
subclass of: sex chromosome

Y chromosome
IAO_0000115: The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.
has db xref: Wikipedia:Y_chromosome
has OBO namespace: cellular_component
id: GO:0000806
type: Class
subclass of: sex chromosome

Z chromosome
IAO_0000115: The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females.
has db xref: Wikipedia:ZW_sex-determination_system
has OBO namespace: cellular_component
id: GO:0000807
type: Class
subclass of: sex chromosome

origin recognition complex
IAO_0000115: A multisubunit complex that is located at the replication origins of a chromosome.
has db xref: Wikipedia:Origin_recognition_complex
has exact synonym: ORC
has exact synonym: origin of replication recognition complex
has OBO namespace: cellular_component
id: GO:0000808
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0043234
subclass of: GO_0044427

cytoplasmic origin of replication recognition complex
IAO_0000115: A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.
has exact synonym: cytoplasmic ORC
has OBO namespace: cellular_component
has related synonym: prokaryotic ORC
id: GO:0000809
in subset: gosubset prok
type: Class
subclass of: origin recognition complex
subclass of: GO_0044444
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic chromosome
subclass of: Restriction
  on property: part_of
  some values from: GO_0005737

diacylglycerol diphosphate phosphatase activity
IAO_0000115: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.
has db xref: EC:3.1.3.81
has db xref: MetaCyc:RXN-11277
has exact synonym: DGPP phosphatase activity
has exact synonym: DGPP phosphohydrolase activity
has exact synonym: diacylglycerol pyrophosphate phosphatase activity
has OBO namespace: molecular_function
id: GO:0000810
type: Class
comment: The enzyme entry for EC 3.1.3.81 states that this is a bifunctional enzyme (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/81.html). However, reaction details are only provided for the cumulative enzymatic activity, therefore this term has not been split into two.
subclass of: GO_0016462

GINS complex
IAO_0000115: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
has exact synonym: Go, Ichi, Ni and San complex
has OBO namespace: cellular_component
id: GO:0000811
type: Class
subclass of: GO_0031261
subclass of: GO_0044454

Swr1 complex
IAO_0000115: A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
has exact synonym: SWR-C
has OBO namespace: cellular_component
id: GO:0000812
type: Class
subclass of: GO_0044454
subclass of: GO_0097346
subclass of: Restriction
  on property: part_of
  some values from: nuclear chromatin

ESCRT I complex
IAO_0000115: An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
has broad synonym: Endosomal Sorting Complex Required for Transport
has OBO namespace: cellular_component
id: GO:0000813
type: Class
subclass of: GO_0043234
subclass of: GO_0044425
subclass of: GO_0044440
subclass of: Restriction
  on property: part_of
  some values from: GO_0010008

ESCRT II complex
IAO_0000115: An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
has broad synonym: Endosomal Sorting Complex Required for Transport
has OBO namespace: cellular_component
id: GO:0000814
type: Class
subclass of: GO_0043234
subclass of: GO_0044425
subclass of: GO_0044440
subclass of: Restriction
  on property: part_of
  some values from: GO_0010008

ESCRT III complex
IAO_0000115: An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.
has broad synonym: Endosomal Sorting Complex Required for Transport
has OBO namespace: cellular_component
id: GO:0000815
type: Class
subclass of: GO_0043234
subclass of: GO_0044425
subclass of: GO_0044440
subclass of: Restriction
  on property: part_of
  some values from: GO_0010008

COMA complex
IAO_0000115: A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly.
has exact synonym: Ctf19p-Okp1p-Mcm1p-Ame1p complex
has OBO namespace: cellular_component
id: GO:0000817
type: Class
subclass of: GO_0043234
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome kinetochore

nuclear MIS12/MIND complex
IAO_0000115: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
has exact synonym: MIND complex
has exact synonym: Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex
has OBO namespace: cellular_component
id: GO:0000818
type: Class
subclass of: MIS12/MIND type complex
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: GO_0005634
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome kinetochore

sister chromatid segregation
IAO_0000115: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
has OBO namespace: biological_process
id: GO:0000819
type: Class
subclass of: GO_0007059
subclass of: GO_0022402
subclass of: GO_0051276

regulation of glutamine family amino acid metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
has exact synonym: regulation of glutamine family amino acid metabolism
has OBO namespace: biological_process
id: GO:0000820
type: Class
subclass of: GO_0006521
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0009064

regulation of arginine metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
has exact synonym: regulation of arginine metabolism
has OBO namespace: biological_process
id: GO:0000821
type: Class
subclass of: regulation of glutamine family amino acid metabolic process
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006525

inositol hexakisphosphate binding
IAO_0000115: Interacting selectively and non-covalently with inositol hexakisphosphate.
has exact synonym: IP6 binding
has exact synonym: InsP6 binding
has OBO namespace: molecular_function
id: GO:0000822
type: Class
subclass of: GO_0043168
subclass of: GO_0043178

inositol-1,4,5-trisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+).
has broad synonym: IpmK
has broad synonym: inositol polyphosphate multikinase activity
has broad synonym: inositol trisphosphate 6-kinase activity
has db xref: EC:2.7.1.151
has db xref: KEGG:R05800
has db xref: MetaCyc:2.7.1.151-RXN
has exact synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity
has OBO namespace: molecular_function
id: GO:0000823
type: Class
subclass of: GO_0051766

inositol tetrakisphosphate 3-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
has broad synonym: EC:2.7.1.151
has broad synonym: IpmK
has broad synonym: inositol polyphosphate multikinase activity
has exact synonym: 1D-myo-inositol-tetrakisphosphate 3-kinase activity
has exact synonym: inositol 1,4,5,6-tetrakisphosphate 3-kinase activity
has OBO namespace: molecular_function
id: GO:0000824
type: Class
subclass of: GO_0051765

inositol tetrakisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.
has db xref: MetaCyc:RXN-7184
has exact synonym: 1D-myo-inositol-tetrakisphosphate 6-kinase activity
has exact synonym: inositol 1,3,4,5-tetrakisphosphate 6-kinase activity
has OBO namespace: molecular_function
id: GO:0000825
type: Class
subclass of: GO_0051765

inositol pyrophosphate synthase activity
IAO_0000115: OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds.
consider: GO:0052746
has exact synonym: inositol diphosphate synthase activity
has OBO namespace: molecular_function
id: GO:0000826
type: Class
comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them.
deprecated: true

inositol-1,3,4,5,6-pentakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.
has broad synonym: EC:2.7.4.21
has OBO namespace: molecular_function
id: GO:0000827
type: Class
subclass of: GO_0016776

inositol hexakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
has OBO namespace: molecular_function
id: GO:0000828
type: Class
subclass of: GO_0016776

inositol heptakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.
has OBO namespace: molecular_function
id: GO:0000829
type: Class
subclass of: GO_0016776

inositol hexakisphosphate 4-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate.
has OBO namespace: molecular_function
id: GO:0000830
type: Class
subclass of: inositol hexakisphosphate kinase activity

inositol hexakisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.
has OBO namespace: molecular_function
id: GO:0000831
type: Class
subclass of: inositol hexakisphosphate kinase activity

inositol hexakisphosphate 5-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
has db xref: EC:2.7.4.21
has db xref: KEGG:R09087
has db xref: MetaCyc:2.7.1.152-RXN
has exact synonym: ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity
has OBO namespace: molecular_function
id: GO:0000832
type: Class
subclass of: inositol hexakisphosphate kinase activity

inositol heptakisphosphate 4-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate.
has exact synonym: IP7 4-kinase activity
has exact synonym: diphosphoinositol-pentakisphosphate 4-kinase activity
has OBO namespace: molecular_function
id: GO:0000833
type: Class
subclass of: inositol heptakisphosphate kinase activity

inositol heptakisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
has OBO namespace: molecular_function
id: GO:0000834
type: Class
subclass of: inositol heptakisphosphate kinase activity

ER ubiquitin ligase complex
IAO_0000115: A ubiquitin ligase complex found in the ER.
has OBO namespace: cellular_component
id: GO:0000835
type: Class
subclass of: cytoplasmic ubiquitin ligase complex
subclass of: GO_0044425
subclass of: GO_0044432
subclass of: Restriction
  on property: part_of
  some values from: GO_0005789
subclass of: Restriction
  on property: part_of
  some values from: GO_0005783

Hrd1p ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
has OBO namespace: cellular_component
id: GO:0000836
type: Class
subclass of: ER ubiquitin ligase complex

Doa10p ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.
has exact synonym: Ssm4p ubiquitin ligase complex
has OBO namespace: cellular_component
id: GO:0000837
type: Class
subclass of: ER ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-M complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
has OBO namespace: cellular_component
id: GO:0000838
type: Class
subclass of: Hrd1p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
has OBO namespace: cellular_component
id: GO:0000839
type: Class
subclass of: Hrd1p ubiquitin ligase complex

translation repressor activity, nucleic acid binding
IAO_0000115: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
has OBO namespace: molecular_function
id: GO:0000900
type: Class
subclass of: GO_0030371
subclass of: GO_0090079

translation repressor activity, non-nucleic acid binding
IAO_0000115: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.
has OBO namespace: molecular_function
id: GO:0000901
type: Class
subclass of: GO_0030371
subclass of: GO_0045183

cell morphogenesis
IAO_0000115: The developmental process in which the size or shape of a cell is generated and organized.
has alternative id: GO:0007148
has alternative id: GO:0045790
has alternative id: GO:0045791
has exact synonym: cellular morphogenesis
has OBO namespace: biological_process
id: GO:0000902
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim yeast
in subset: gosubset prok
type: Class
subclass of: GO_0032989

regulation of cell shape during vegetative growth phase
IAO_0000115: Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods.
has alternative id: GO:0090061
has OBO namespace: biological_process
has related synonym: cell morphogenesis during vegetative growth phase
has related synonym: cellular morphogenesis during vegetative growth
has related synonym: regulation of cell morphogenesis during vegetative growth phase
id: GO:0000903
type: Class
subclass of: GO_0008360
subclass of: Restriction
  on property: part_of
  some values from: GO_0072690

cell morphogenesis involved in differentiation
IAO_0000115: The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
has OBO namespace: biological_process
id: GO:0000904
type: Class
subclass of: cell morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: GO_0048468

sporocarp development involved in asexual reproduction
IAO_0000115: The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction.
has broad synonym: fruiting body formation involved in asexual reproduction
has narrow synonym: conidium development
has narrow synonym: imperfect stage fruiting body development
has OBO namespace: biological_process
has related synonym: haploid fruiting
has related synonym: homokaryotic fruiting
has related synonym: monokaryotic fruiting
id: GO:0000905
type: Class
subclass of: GO_0030584
subclass of: Restriction
  on property: part_of
  some values from: GO_0019954

6,7-dimethyl-8-ribityllumazine synthase activity
IAO_0000115: Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
has broad synonym: lumazine synthase activity
has db xref: EC:5.4.-.-
has OBO namespace: molecular_function
id: GO:0000906
type: Class
subclass of: GO_0016867

sulfonate dioxygenase activity
IAO_0000115: Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.
has db xref: EC:1.14.11.-
has exact synonym: sulfonate/alpha-ketoglutarate dioxygenase activity
has exact synonym: sulphonate dioxygenase activity
has OBO namespace: molecular_function
id: GO:0000907
in subset: gosubset prok
type: Class
subclass of: GO_0016706

taurine dioxygenase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite.
has db xref: EC:1.14.11.17
has db xref: KEGG:R05320
has db xref: MetaCyc:RXN0-299
has db xref: RHEA:15912
has exact synonym: 2-aminoethanesulfonate dioxygenase activity
has exact synonym: alpha-ketoglutarate-dependent taurine dioxygenase activity
has exact synonym: taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)
has OBO namespace: molecular_function
id: GO:0000908
in subset: gosubset prok
type: Class
subclass of: GO_0016706

sporocarp development involved in sexual reproduction
IAO_0000115: The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi.
has broad synonym: fruiting body development involved in sexual reproduction
has broad synonym: fruiting body formation involved in sexual reproduction
has narrow synonym: ascus development
has narrow synonym: perfect stage fruiting body development
has OBO namespace: biological_process
id: GO:0000909
type: Class
subclass of: GO_0030584
subclass of: Restriction
  on property: part_of
  some values from: GO_0019953

cytokinesis
IAO_0000115: The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components, and occurs after division of the nucleus.
has alternative id: GO:0007104
has alternative id: GO:0016288
has db xref: Reactome:REACT_101918
has db xref: Reactome:REACT_108805
has db xref: Reactome:REACT_1932
has db xref: Reactome:REACT_30667
has db xref: Reactome:REACT_32636
has db xref: Reactome:REACT_78494
has db xref: Reactome:REACT_84722
has db xref: Reactome:REACT_87726
has db xref: Reactome:REACT_92849
has db xref: Reactome:REACT_93374
has db xref: Reactome:REACT_94382
has db xref: Reactome:REACT_98952
has db xref: Reactome:REACT_99118
has db xref: Wikipedia:Cytokinesis
has OBO namespace: biological_process
id: GO:0000910
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim pombe
in subset: goslim yeast
in subset: gosubset prok
type: Class
comment: Note that most eukaryotic gene products involved in canonical cytokinesis during the cell cycle can be annotated to 'cell cycle cytokinesis ; GO:0033205' or its descendants. See also 'cell division ; GO:0051301'. Note that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division.
subclass of: GO_0044763
subclass of: Restriction
  on property: part_of
  some values from: GO_0051301

cytokinesis by cell plate formation
IAO_0000115: The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana.
has OBO namespace: biological_process
id: GO:0000911
type: Class
subclass of: GO_0033205

assembly of actomyosin apparatus involved in cell cycle cytokinesis
IAO_0000115: The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis.
has exact synonym: actomyosin apparatus assembly involved in cytokinesis
has exact synonym: cytokinesis, formation of actomyosin apparatus
has OBO namespace: biological_process
has related synonym: formation of actomyosin apparatus involved in cytokinesis
id: GO:0000912
type: Class
subclass of: GO_0022607
subclass of: GO_0031032
subclass of: GO_0032506
subclass of: Restriction
  on property: part_of
  some values from: GO_0033205

preprophase band assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation.
has OBO namespace: biological_process
has related synonym: preprophase band formation
id: GO:0000913
type: Class
subclass of: GO_0007105
subclass of: GO_0022607
subclass of: Restriction
  on property: part_of
  some values from: cytokinesis by cell plate formation

phragmoplast assembly
IAO_0000115: The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles).
has OBO namespace: biological_process
has related synonym: phragmoplast formation
id: GO:0000914
type: Class
subclass of: assembly of actomyosin apparatus involved in cell cycle cytokinesis
subclass of: Restriction
  on property: part_of
  some values from: cytokinesis by cell plate formation

cytokinesis, actomyosin contractile ring assembly
IAO_0000115: The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
has alternative id: GO:0045573
has exact synonym: contractile ring assembly
has narrow synonym: constriction ring assembly
has OBO namespace: biological_process
has related synonym: cytokinesis, actomyosin contractile ring formation
has related synonym: cytokinesis, actomyosin ring biosynthesis
has related synonym: cytokinesis, actomyosin ring formation
has related synonym: cytokinesis, contractile ring assembly
id: GO:0000915
type: Class
subclass of: assembly of actomyosin apparatus involved in cell cycle cytokinesis

actomyosin contractile ring contraction
IAO_0000115: The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle.
has broad synonym: contractile ring constriction
has broad synonym: cytokinesis, contractile ring contraction
has exact synonym: contractile ring contraction involved in cell cycle cytokinesis
has exact synonym: cytokinesis, actomyosin ring contraction
has OBO namespace: biological_process
id: GO:0000916
type: Class
subclass of: GO_0036213
subclass of: Restriction
  on property: part_of
  some values from: GO_0033205

barrier septum assembly
IAO_0000115: The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material.
has broad synonym: septation
has exact synonym: barrier septum formation
has exact synonym: formation of barrier septum
has OBO namespace: biological_process
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum formation
id: GO:0000917
type: Class
subclass of: GO_0022607
subclass of: GO_0032506

barrier septum site selection
IAO_0000115: The process of marking the site where a barrier septum will form.
has broad synonym: septin assembly and septum biosynthesis
has broad synonym: septin assembly and septum formation
has exact synonym: selection of site for barrier cell septum biosynthesis
has exact synonym: selection of site for barrier cell septum formation
has exact synonym: selection of site for barrier septum formation
has exact synonym: septum positioning
has OBO namespace: biological_process
id: GO:0000918
type: Class
subclass of: GO_0032506
subclass of: Restriction
  on property: part_of
  some values from: barrier septum assembly

cell plate assembly
IAO_0000115: The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast.
has OBO namespace: biological_process
has related synonym: cell plate formation
id: GO:0000919
type: Class
subclass of: GO_0022607
subclass of: GO_0032506
subclass of: Restriction
  on property: part_of
  some values from: cytokinesis by cell plate formation

cytokinetic cell separation
IAO_0000115: The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components.
has narrow synonym: rotokinesis
has OBO namespace: biological_process
has related synonym: cell separation during cytokinesis
id: GO:0000920
type: Class
subclass of: GO_0032506

septin ring assembly
IAO_0000115: The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.
has broad synonym: septin assembly and septum biosynthesis
has broad synonym: septin assembly and septum formation
has OBO namespace: biological_process
id: GO:0000921
in subset: gosubset prok
type: Class
subclass of: GO_0043623
subclass of: Restriction
  on property: part_of
  some values from: GO_0031106

spindle pole
IAO_0000115: Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
has alternative id: GO:0030615
has OBO namespace: cellular_component
id: GO:0000922
type: Class
subclass of: GO_0044430
subclass of: Restriction
  on property: part_of
  some values from: GO_0005819

equatorial microtubule organizing center
IAO_0000115: A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.
has exact synonym: EMTOC
has exact synonym: equatorial microtubule organising centre
has OBO namespace: cellular_component
id: GO:0000923
type: Class
subclass of: GO_0005815
subclass of: GO_0032155
subclass of: Restriction
  on property: part_of
  some values from: GO_0032153

gamma-tubulin ring complex, centrosomal
IAO_0000115: A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring.
has alternative id: GO:0000925
has alternative id: GO:0000926
has exact synonym: gamma-tubulin large complex, centrosomal
has OBO namespace: cellular_component
id: GO:0000924
type: Class
subclass of: GO_0008274
subclass of: Restriction
  on property: part_of
  some values from: pericentriolar material

gamma-tubulin small complex, centrosomal
IAO_0000115: A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus.
has OBO namespace: cellular_component
id: GO:0000927
type: Class
subclass of: GO_0008275

gamma-tubulin small complex, spindle pole body
IAO_0000115: A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: Tub4 complex
has OBO namespace: cellular_component
id: GO:0000928
type: Class
subclass of: GO_0008275
subclass of: Restriction
  on property: part_of
  some values from: GO_0005816

gamma-tubulin complex
IAO_0000115: A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.
has OBO namespace: cellular_component
id: GO:0000930
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044450

gamma-tubulin large complex
IAO_0000115: A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.
has alternative id: GO:0000929
has OBO namespace: cellular_component
id: GO:0000931
type: Class
subclass of: gamma-tubulin complex

cytoplasmic mRNA processing body
IAO_0000115: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.
has db xref: Wikipedia:P_body
has exact synonym: P body
has exact synonym: P-body
has OBO namespace: cellular_component
has related synonym: cytoplasmic foci
id: GO:0000932
type: Class
subclass of: GO_0035770
subclass of: GO_0044444

adventitious septum
IAO_0000115: A cell septum whose formation is independent of nuclear division.
has OBO namespace: cellular_component
id: GO:0000933
type: Class
subclass of: GO_0030428

porous cell septum
IAO_0000115: A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments.
has broad synonym: porous septum
has OBO namespace: cellular_component
id: GO:0000934
type: Class
subclass of: GO_0030428

barrier septum
IAO_0000115: A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
has exact synonym: complete septum
has OBO namespace: cellular_component
id: GO:0000935
type: Class
subclass of: GO_0030428

primary cell septum
IAO_0000115: A cell septum that forms following nuclear division.
has broad synonym: primary septum
has OBO namespace: cellular_component
id: GO:0000936
type: Class
subclass of: GO_0030428

dolipore septum
IAO_0000115: A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome).
has OBO namespace: cellular_component
id: GO:0000937
type: Class
subclass of: porous cell septum

GARP complex
IAO_0000115: A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.
has exact synonym: Golgi associated retrograde protein complex
has exact synonym: VFT tethering complex
has exact synonym: Vps fifty three tethering complex
has OBO namespace: cellular_component
id: GO:0000938
type: Class
subclass of: GO_0043234
subclass of: GO_0044431
subclass of: GO_0044433
subclass of: Restriction
  on property: part_of
  some values from: GO_0016023

condensed chromosome inner kinetochore
IAO_0000115: The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
has exact synonym: inner kinetochore of condensed chromosome
has narrow synonym: inner kinetochore plate
has OBO namespace: cellular_component
has related synonym: inner centromere core complex
id: GO:0000939
type: Class
subclass of: GO_0043234
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome kinetochore

condensed chromosome outer kinetochore
IAO_0000115: The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
has exact synonym: outer kinetochore of condensed chromosome
has narrow synonym: outer kinetochore plate
has OBO namespace: cellular_component
id: GO:0000940
type: Class
subclass of: GO_0043234
subclass of: GO_0044427
subclass of: Restriction
  on property: part_of
  some values from: condensed chromosome kinetochore

condensed nuclear chromosome inner kinetochore
IAO_0000115: The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
has exact synonym: inner kinetochore of condensed nuclear chromosome
has OBO namespace: cellular_component
id: GO:0000941
type: Class
subclass of: condensed chromosome inner kinetochore
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome kinetochore

condensed nuclear chromosome outer kinetochore
IAO_0000115: The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
has exact synonym: outer kinetochore of condensed nuclear chromosome
has OBO namespace: cellular_component
id: GO:0000942
type: Class
subclass of: condensed chromosome outer kinetochore
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: condensed nuclear chromosome kinetochore

retrotransposon nucleocapsid
IAO_0000115: A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog.
has db xref: Wikipedia:Virus-like_particle
has exact synonym: VLP
has exact synonym: Virus-like particle
has OBO namespace: cellular_component
id: GO:0000943
type: Class
subclass of: GO_0044428

base pairing with rRNA
IAO_0000115: Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule.
has OBO namespace: molecular_function
id: GO:0000944
type: Class
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: base pairing with RNA
subclass of: GO_0019843

base pairing with snRNA
IAO_0000115: Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule.
has OBO namespace: molecular_function
id: GO:0000945
type: Class
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: base pairing with RNA
subclass of: GO_0017069

base pairing with tRNA
IAO_0000115: Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule.
has OBO namespace: molecular_function
id: GO:0000946
type: Class
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
subclass of: tRNA binding
subclass of: base pairing with RNA

amino acid catabolic process to alcohol via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
has OBO namespace: biological_process
id: GO:0000947
type: Class
subclass of: amino acid catabolic process via Ehrlich pathway
subclass of: GO_0046165

amino acid catabolic process to carboxylic acid via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
has OBO namespace: biological_process
id: GO:0000948
type: Class
subclass of: amino acid catabolic process via Ehrlich pathway
subclass of: GO_0046394

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
has OBO namespace: biological_process
id: GO:0000949
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009074

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
has exact synonym: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway
has OBO namespace: biological_process
id: GO:0000950
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009083

methionine catabolic process to 3-methylthiopropanol
IAO_0000115: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
has OBO namespace: biological_process
id: GO:0000951
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009087
subclass of: GO_0044272

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
has OBO namespace: biological_process
id: GO:0000952
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0009074

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
has exact synonym: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway
has OBO namespace: biological_process
id: GO:0000953
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0009083

methionine catabolic process to 3-methylthiopropanoate
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
has OBO namespace: biological_process
id: GO:0000954
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0006633
subclass of: GO_0009087
subclass of: GO_0044272

amino acid catabolic process via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.
has OBO namespace: biological_process
id: GO:0000955
type: Class
subclass of: GO_0009063

nuclear-transcribed mRNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
has exact synonym: nuclear mRNA breakdown
has exact synonym: nuclear mRNA catabolism
has exact synonym: nuclear mRNA degradation
has OBO namespace: biological_process
id: GO:0000956
type: Class
subclass of: GO_0006402

mitochondrial RNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
has OBO namespace: biological_process
id: GO:0000957
type: Class
subclass of: mitochondrial RNA metabolic process
subclass of: GO_0006401

mitochondrial mRNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
has OBO namespace: biological_process
id: GO:0000958
type: Class
subclass of: mitochondrial RNA catabolic process
subclass of: GO_0006402

mitochondrial RNA metabolic process
IAO_0000115: The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
has OBO namespace: biological_process
id: GO:0000959
type: Class
subclass of: GO_0016070

regulation of mitochondrial RNA catabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
has OBO namespace: biological_process
id: GO:0000960
type: Class
subclass of: GO_0031329
subclass of: GO_0051252
subclass of: Restriction
  on property: RO_0002211
  some values from: mitochondrial RNA catabolic process

negative regulation of mitochondrial RNA catabolic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
has OBO namespace: biological_process
id: GO:0000961
type: Class
subclass of: regulation of mitochondrial RNA catabolic process
subclass of: GO_0031330
subclass of: GO_0051253
subclass of: Restriction
  on property: RO_0002212
  some values from: mitochondrial RNA catabolic process

positive regulation of mitochondrial RNA catabolic process
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
has OBO namespace: biological_process
id: GO:0000962
type: Class
subclass of: regulation of mitochondrial RNA catabolic process
subclass of: GO_0031331
subclass of: GO_0051254
subclass of: Restriction
  on property: RO_0002213
  some values from: mitochondrial RNA catabolic process

mitochondrial RNA processing
IAO_0000115: The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.
has OBO namespace: biological_process
id: GO:0000963
type: Class
subclass of: mitochondrial RNA metabolic process
subclass of: GO_0006396
subclass of: GO_0007005

mitochondrial RNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
has OBO namespace: biological_process
has related synonym: mitochondrial RNA 5' end processing
id: GO:0000964
type: Class
subclass of: mitochondrial RNA processing
subclass of: RNA 5'-end processing

mitochondrial RNA 3'-end processing
IAO_0000115: Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
has OBO namespace: biological_process
has related synonym: mitochondrial RNA 3' end processing
id: GO:0000965
type: Class
subclass of: mitochondrial RNA processing
subclass of: GO_0031123

RNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an RNA molecule.
has exact synonym: RNA 5' end processing
has OBO namespace: biological_process
id: GO:0000966
type: Class
subclass of: GO_0006396

rRNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an rRNA molecule.
has exact synonym: rRNA 5' end processing
has OBO namespace: biological_process
id: GO:0000967
type: Class
subclass of: GO_0034471

tRNA exon ligation
IAO_0000115: An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed.
has OBO namespace: biological_process
id: GO:0000968
type: Class
subclass of: RNA exon ligation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006388

tRNA exon ligation utilizing ATP as source of linkage phosphate
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species.
has OBO namespace: biological_process
id: GO:0000969
type: Class
subclass of: tRNA exon ligation

tRNA exon ligation utilizing GTP as source of linkage phosphate
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process.
has OBO namespace: biological_process
id: GO:0000970
type: Class
subclass of: tRNA exon ligation

tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans.
has OBO namespace: biological_process
id: GO:0000971
type: Class
subclass of: tRNA exon ligation

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
IAO_0000115: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.
has OBO namespace: biological_process
id: GO:0000972
type: Class
subclass of: GO_0051276

posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
IAO_0000115: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.
has OBO namespace: biological_process
id: GO:0000973
type: Class
subclass of: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Prp19 complex
IAO_0000115: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
has narrow synonym: Prp19/CDC5 complex
has narrow synonym: nineteen complex
has OBO namespace: cellular_component
has related synonym: NTC
id: GO:0000974
type: Class
subclass of: GO_0043234

regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
has OBO namespace: molecular_function
id: GO:0000975
type: Class
subclass of: regulatory region nucleic acid binding
subclass of: DNA binding

transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0000976
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: GO_0043565
subclass of: GO_0044212

RNA polymerase II regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
has OBO namespace: molecular_function
id: GO:0000977
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: RNA polymerase II regulatory region DNA binding

RNA polymerase II core promoter proximal region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
has OBO namespace: molecular_function
has related synonym: RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding
id: GO:0000978
type: Class
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
subclass of: RNA polymerase II regulatory region sequence-specific DNA binding
subclass of: core promoter proximal region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
has OBO namespace: molecular_function
id: GO:0000979
type: Class
subclass of: RNA polymerase II regulatory region sequence-specific DNA binding
subclass of: core promoter sequence-specific DNA binding

RNA polymerase II distal enhancer sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
has OBO namespace: molecular_function
id: GO:0000980
type: Class
comment: Note that distal enhancers of the type found in mammalian cells are not known to occur in either Saccharomyces cerevisiae or Schizosaccharomyces pombe. While some S. cerevisiae literature does refer to sequences distal to the initiation site, these distal sites do not seem to function independently of position or orientation as mammalian distal enhancers do and are not considered to be enhancers.
subclass of: RNA polymerase II regulatory region sequence-specific DNA binding
subclass of: enhancer sequence-specific DNA binding

sequence-specific DNA binding RNA polymerase II transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0000981
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0000982
type: Class
subclass of: sequence-specific DNA binding RNA polymerase II transcription factor activity

RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0000983
type: Class
subclass of: sequence-specific DNA binding RNA polymerase II transcription factor activity

bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase.
has OBO namespace: molecular_function
has related synonym: eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding
id: GO:0000984
in subset: gosubset prok
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: bacterial-type RNA polymerase regulatory region DNA binding

bacterial-type RNA polymerase core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in a bacterial-type RNA polymerase core promoter, the region composed of the transcription start site and binding sites for transcription factors of the basal transcription machinery, in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has exact synonym: eubacterial-type RNA polymerase core promoter sequence-specific DNA binding
has OBO namespace: molecular_function
id: GO:0000985
in subset: gosubset prok
type: Class
subclass of: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
subclass of: core promoter sequence-specific DNA binding

bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase.
has exact synonym: eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding
has OBO namespace: molecular_function
id: GO:0000986
in subset: gosubset prok
type: Class
subclass of: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
subclass of: core promoter proximal region sequence-specific DNA binding

core promoter proximal region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0000987
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: core promoter proximal region DNA binding

protein binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has broad synonym: transcription factor activity
has OBO namespace: molecular_function
id: GO:0000988
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim yeast
in subset: high level annotation qc
type: Class
subclass of: molecular_function

transcription factor binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0000989
type: Class
subclass of: protein binding transcription factor activity

core RNA polymerase binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0000990
type: Class
subclass of: protein binding transcription factor activity

core RNA polymerase II binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0000991
type: Class
subclass of: core RNA polymerase binding transcription factor activity

polymerase III regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes.
has OBO namespace: molecular_function
id: GO:0000992
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III regulatory region DNA binding

RNA polymerase II core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
has OBO namespace: molecular_function
id: GO:0000993
type: Class
subclass of: basal RNA polymerase II transcription machinery binding
subclass of: GO_0032403
subclass of: GO_0043175

RNA polymerase III core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
has OBO namespace: molecular_function
id: GO:0000994
type: Class
subclass of: GO_0043175

core RNA polymerase III binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0000995
type: Class
subclass of: core RNA polymerase binding transcription factor activity

core DNA-dependent RNA polymerase binding promoter specificity activity
IAO_0000115: Interacting selectively and non-covalently with a DNA-dependent core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of promoter DNA sequence motifs.
has OBO namespace: molecular_function
id: GO:0000996
type: Class
subclass of: core RNA polymerase binding transcription factor activity

mitochondrial RNA polymerase core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is part of the core promoter for the mitochondrial RNA polymerase.
has OBO namespace: molecular_function
id: GO:0000997
type: Class
subclass of: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
subclass of: core promoter sequence-specific DNA binding

RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 1 promoters require TFIIIA for promoter recognition, which then recruits TFIIIC. TFIIIC in turn recruits TFIIIB, which recruits Pol III to the promoter.
has OBO namespace: biological_process
id: GO:0000999
type: Class
subclass of: GO_0070898
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from RNA polymerase III type 1 promoter

bacterial-type RNA polymerase core enzyme binding
IAO_0000115: Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.
has exact synonym: eubacterial-type RNA polymerase core enzyme binding
has OBO namespace: molecular_function
id: GO:0001000
in subset: gosubset prok
type: Class
comment: Should omega be included here?
subclass of: GO_0043175

mitochondrial single-subunit type RNA polymerase binding
IAO_0000115: Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
has OBO namespace: molecular_function
id: GO:0001001
type: Class
subclass of: single-subunit type RNA polymerase binding

RNA polymerase III type 1 promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
has OBO namespace: molecular_function
id: GO:0001002
type: Class
subclass of: polymerase III regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III type 1 promoter DNA binding

RNA polymerase III type 2 promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
has OBO namespace: molecular_function
id: GO:0001003
type: Class
subclass of: polymerase III regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III type 2 promoter DNA binding

RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
IAO_0000115: The function of binding to a specific DNA sequence motif in an RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter.
has OBO namespace: molecular_function
id: GO:0001004
type: Class
subclass of: sequence-specific DNA binding transcription factor recruiting transcription factor activity
subclass of: sequence-specific DNA binding RNA polymerase III transcription factor activity
subclass of: RNA polymerase III transcription factor recruiting transcription factor activity

RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
IAO_0000115: The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC.
has OBO namespace: molecular_function
has related synonym: TFIIIA activity
has related synonym: TFIIIC-type activity
id: GO:0001005
type: Class
comment: This represents TFIIIA.
subclass of: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity

RNA polymerase III type 3 promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
has OBO namespace: molecular_function
id: GO:0001006
type: Class
subclass of: polymerase III regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III type 3 promoter DNA binding

RNA polymerase III transcription factor binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001007
type: Class
subclass of: transcription factor binding transcription factor activity

RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence motif in a type 2 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 2 Pol III promoters, this requires TFIIIC activity.
has exact synonym: type 2 RNA polymerase III promoter recognition
has OBO namespace: molecular_function
has related synonym: TFIIIC-type activity
id: GO:0001008
type: Class
subclass of: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity

transcription from RNA polymerase III type 2 promoter
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 2 RNAP III promoter. Type 2 RNAP III promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
has OBO namespace: biological_process
id: GO:0001009
type: Class
subclass of: GO_0006383

sequence-specific DNA binding transcription factor recruiting transcription factor activity
IAO_0000115: The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
has OBO namespace: molecular_function
id: GO:0001010
type: Class
subclass of: transcription factor recruiting transcription factor activity
subclass of: sequence-specific DNA binding transcription factor activity

sequence-specific DNA binding RNA polymerase recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC).
has OBO namespace: molecular_function
id: GO:0001011
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

RNA polymerase II regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has OBO namespace: molecular_function
id: GO:0001012
type: Class
subclass of: GO_0044212

RNA polymerase I regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has OBO namespace: molecular_function
id: GO:0001013
type: Class
subclass of: GO_0044212

snoRNA transcription from a type 2 RNA polymerase III promoter
IAO_0000115: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter.
has OBO namespace: biological_process
id: GO:0001014
type: Class
subclass of: transcription from RNA polymerase III type 2 promoter
subclass of: GO_0009302

snoRNA transcription from an RNA polymerase II promoter
IAO_0000115: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
has OBO namespace: biological_process
id: GO:0001015
type: Class
subclass of: GO_0006366
subclass of: GO_0009302

RNA polymerase III regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has OBO namespace: molecular_function
id: GO:0001016
type: Class
subclass of: GO_0044212

bacterial-type RNA polymerase regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has exact synonym: eubacterial-type RNA polymerase regulatory region DNA binding
has OBO namespace: molecular_function
id: GO:0001017
in subset: gosubset prok
type: Class
subclass of: GO_0044212

mitochondrial RNA polymerase regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by mitochondrial RNA polymerase. Binding may occur as a high affinity and sequence specific interaction or as a lower affinity interaction observed once a factor has been recruited to the DNA by other factors.
has OBO namespace: molecular_function
id: GO:0001018
type: Class
subclass of: GO_0044212

plastid RNA polymerase regulatory region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has OBO namespace: molecular_function
id: GO:0001019
type: Class
subclass of: GO_0044212

RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription.
has OBO namespace: biological_process
id: GO:0001020
type: Class
subclass of: GO_0070898
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from RNA polymerase III type 3 promoter

RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on a type 2 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 2 promoters require TFIIIC for promoter recognition, which then recruits TFIIIB, which in turn which recruits Pol III to the promoter.
has OBO namespace: biological_process
id: GO:0001021
type: Class
subclass of: GO_0070898
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from RNA polymerase III type 2 promoter

transcription initiation from RNA polymerase III type 1 promoter
IAO_0000115: A transcription initiation process on a type 1 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
has OBO namespace: biological_process
id: GO:0001022
type: Class
subclass of: GO_0006384
subclass of: Restriction
  on property: part_of
  some values from: GO_0042791

transcription initiation from RNA polymerase III type 2 promoter
IAO_0000115: A transcription initiation process on a type 2 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
has OBO namespace: biological_process
id: GO:0001023
type: Class
subclass of: GO_0006384
subclass of: Restriction
  on property: part_of
  some values from: transcription from RNA polymerase III type 2 promoter

transcription initiation from RNA polymerase III type 3 promoter
IAO_0000115: A transcription initiation process on a type 3 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
has OBO namespace: biological_process
id: GO:0001024
type: Class
subclass of: GO_0006384
subclass of: Restriction
  on property: part_of
  some values from: transcription from RNA polymerase III type 3 promoter

RNA polymerase III transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III.
has OBO namespace: molecular_function
id: GO:0001025
type: Class
subclass of: GO_0008134

TFIIIB-type transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
has exact synonym: RNA polymerase III recruiting transcription factor activity
has OBO namespace: molecular_function
id: GO:0001026
type: Class
subclass of: core RNA polymerase III binding transcription factor activity
subclass of: RNA polymerase III transcription factor binding transcription factor activity

RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
has OBO namespace: molecular_function
has related synonym: RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity
id: GO:0001027
type: Class
subclass of: TFIIIB-type transcription factor activity

RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
has OBO namespace: molecular_function
has related synonym: RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity
id: GO:0001028
type: Class
subclass of: TFIIIB-type transcription factor activity

RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
has OBO namespace: molecular_function
has related synonym: RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity
id: GO:0001029
type: Class
subclass of: TFIIIB-type transcription factor activity

RNA polymerase III type 1 promoter DNA binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
has OBO namespace: molecular_function
id: GO:0001030
type: Class
subclass of: RNA polymerase III regulatory region DNA binding
subclass of: GO_0080084

RNA polymerase III type 2 promoter DNA binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
has OBO namespace: molecular_function
id: GO:0001031
type: Class
subclass of: RNA polymerase III regulatory region DNA binding

RNA polymerase III type 3 promoter DNA binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
has OBO namespace: molecular_function
id: GO:0001032
type: Class
subclass of: RNA polymerase III regulatory region DNA binding

RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity
IAO_0000115: The function of binding to a specific DNA sequence motif in a type 3 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 3 Pol III promoters, this requires SNAPc activity.
has exact synonym: type 3 RNA polymerase III promoter recognition
has OBO namespace: molecular_function
has related synonym: SNAPc-type activity
id: GO:0001033
type: Class
comment: This represents TFIIIC.
subclass of: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity

sequence-specific DNA binding RNA polymerase III transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase III. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001034
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

transcription from RNA polymerase III type 3 promoter
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 3 RNAP III promoter. A type 3 RNAP III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
has narrow synonym: U6 snRNA transcription (mammalian)
has OBO namespace: biological_process
id: GO:0001035
type: Class
subclass of: GO_0006383

transcription initiation from RNA polymerase III hybrid type promoter
IAO_0000115: A transcription initiation process on a hybrid type RNA polymerase III (Pol III) that results in RNA synthesis by Pol III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.
has OBO namespace: biological_process
id: GO:0001036
type: Class
subclass of: GO_0006384
subclass of: Restriction
  on property: part_of
  some values from: transcription from a RNA polymerase III hybrid type promoter

RNA polymerase III hybrid type promoter DNA binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.
has OBO namespace: molecular_function
id: GO:0001037
type: Class
subclass of: RNA polymerase III regulatory region DNA binding

RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity
IAO_0000115: Once recruited to an RNA polymerase III hybrid type promoter by sequence-specific DNA binding transcription factors, direct DNA binding, or a combination of both, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
has OBO namespace: molecular_function
id: GO:0001038
type: Class
subclass of: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity

RNA polymerase III hybrid type promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.
has OBO namespace: molecular_function
id: GO:0001039
type: Class
subclass of: polymerase III regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III hybrid type promoter DNA binding

RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
has OBO namespace: molecular_function
id: GO:0001040
type: Class
subclass of: TFIIIB-type transcription factor activity

transcription from a RNA polymerase III hybrid type promoter
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase III, originating at a hybrid type RNA polymerase III (RNAP III) promoter. A hybrid RNAP III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.
has narrow synonym: U2 snRNA transcription (S. cerevisiae)
has OBO namespace: biological_process
id: GO:0001041
type: Class
subclass of: GO_0006383

RNA polymerase I core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
has OBO namespace: molecular_function
id: GO:0001042
type: Class
subclass of: GO_0043175

RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on a hybrid type RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Hybrid type promoters contain both gene-internal and upstream elements. An example of a hybrid promoter is the U6 snRNA gene.
has OBO namespace: biological_process
id: GO:0001043
type: Class
subclass of: GO_0070898

mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that controls the transcription of a region of DNA by mitochondrial RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001044
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: mitochondrial RNA polymerase regulatory region DNA binding

mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001045
type: Class
subclass of: core promoter proximal region sequence-specific DNA binding
subclass of: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding

core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0001046
type: Class
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: core promoter binding

core promoter binding
IAO_0000115: Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has OBO namespace: molecular_function
id: GO:0001047
type: Class
subclass of: GO_0044212

RNA polymerase IV core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production.
has OBO namespace: molecular_function
id: GO:0001048
type: Class
subclass of: GO_0043175

RNA polymerase V core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing.
has OBO namespace: molecular_function
id: GO:0001049
type: Class
subclass of: GO_0043175

single-subunit type RNA polymerase binding
IAO_0000115: Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
has exact synonym: SP6-type RNA polymerase binding
has exact synonym: T3-type RNA polymerase binding
has exact synonym: T3/T7 type RNA polymerase binding
has exact synonym: T7-type RNA polymerase binding
has OBO namespace: molecular_function
id: GO:0001050
type: Class
subclass of: GO_0070063

plastid single-subunit type RNA polymerase binding
IAO_0000115: Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
has OBO namespace: molecular_function
id: GO:0001051
type: Class
subclass of: single-subunit type RNA polymerase binding

plastid PEP RNA polymerase core enzyme binding
IAO_0000115: Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.
has OBO namespace: molecular_function
id: GO:0001052
type: Class
subclass of: bacterial-type RNA polymerase core enzyme binding

plastid sigma factor activity
IAO_0000115: Interacting selectively and non-covalently with a plastid PEP core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of plastid PEP core promoter DNA sequence motifs.
has OBO namespace: molecular_function
has related synonym: sigma transcription factor
id: GO:0001053
in subset: gosubset prok
type: Class
subclass of: GO_0016987

RNA polymerase I activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter
has OBO namespace: molecular_function
id: GO:0001054
type: Class
subclass of: DNA-directed RNA polymerase activity

RNA polymerase II activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter
has OBO namespace: molecular_function
id: GO:0001055
type: Class
subclass of: DNA-directed RNA polymerase activity

RNA polymerase III activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter
has OBO namespace: molecular_function
id: GO:0001056
type: Class
subclass of: DNA-directed RNA polymerase activity

RNA polymerase IV activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter
has OBO namespace: molecular_function
id: GO:0001057
type: Class
subclass of: DNA-directed RNA polymerase activity

RNA polymerase V activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter
has OBO namespace: molecular_function
id: GO:0001058
type: Class
subclass of: DNA-directed RNA polymerase activity

transcription from RNA polymerase IV promoter
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase IV (Pol III), originating at a Pol IV-specific promoter.
has exact synonym: transcription from RNA pol IV promoter
has OBO namespace: biological_process
id: GO:0001059
type: Class
subclass of: GO_0006351

transcription from RNA polymerase V promoter
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase V (Pol III), originating at a Pol V-specific promoter.
has exact synonym: transcription from RNA pol V promoter
has OBO namespace: biological_process
id: GO:0001060
type: Class
subclass of: GO_0006351

bacterial-type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has OBO namespace: molecular_function
id: GO:0001061
type: Class
subclass of: DNA-directed RNA polymerase activity

plastid PEP-A RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has OBO namespace: molecular_function
id: GO:0001062
type: Class
subclass of: bacterial-type RNA polymerase activity

plastid PEP-B RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has OBO namespace: molecular_function
id: GO:0001063
type: Class
subclass of: bacterial-type RNA polymerase activity

single subunit type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: T3/T7 type RNA polymerase activity
has OBO namespace: molecular_function
id: GO:0001064
type: Class
subclass of: DNA-directed RNA polymerase activity

mitochondrial single subunit type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type mitochondrial RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has OBO namespace: molecular_function
id: GO:0001065
type: Class
subclass of: single subunit type RNA polymerase activity

plastid single subunit type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has OBO namespace: molecular_function
id: GO:0001066
type: Class
subclass of: single subunit type RNA polymerase activity

regulatory region nucleic acid binding
IAO_0000115: Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
has OBO namespace: molecular_function
id: GO:0001067
type: Class
subclass of: nucleic acid binding

transcription regulatory region RNA binding
IAO_0000115: Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0001068
type: Class
subclass of: regulatory region RNA binding

regulatory region RNA binding
IAO_0000115: Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
has OBO namespace: molecular_function
id: GO:0001069
type: Class
subclass of: regulatory region nucleic acid binding
subclass of: RNA binding

RNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has broad synonym: transcription factor activity
has OBO namespace: molecular_function
id: GO:0001070
type: Class
subclass of: nucleic acid binding transcription factor activity

nucleic acid binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has broad synonym: transcription factor activity
has OBO namespace: molecular_function
id: GO:0001071
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim yeast
in subset: high level annotation qc
type: Class
subclass of: molecular_function

RNA binding transcription antitermination factor activity
IAO_0000115: Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein.
has OBO namespace: molecular_function
id: GO:0001072
in subset: gosubset prok
type: Class
subclass of: RNA binding transcription factor activity

DNA binding transcription antitermination factor activity
IAO_0000115: Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.
has OBO namespace: molecular_function
id: GO:0001073
in subset: gosubset prok
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.
has OBO namespace: molecular_function
id: GO:0001074
type: Class
subclass of: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity

RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.
has exact synonym: sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly
has OBO namespace: molecular_function
id: GO:0001075
type: Class
subclass of: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity

RNA polymerase II transcription factor binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001076
type: Class
subclass of: transcription factor binding transcription factor activity

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
has OBO namespace: molecular_function
id: GO:0001077
type: Class
subclass of: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has OBO namespace: molecular_function
id: GO:0001078
type: Class
subclass of: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

nitrogen catabolite regulation of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
has OBO namespace: biological_process
id: GO:0001079
type: Class
subclass of: GO_0006357
subclass of: GO_0090293

nitrogen catabolite activation of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
has OBO namespace: biological_process
id: GO:0001080
type: Class
subclass of: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0090294

nitrogen catabolite repression of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
has OBO namespace: biological_process
id: GO:0001081
type: Class
subclass of: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0090295

RNA polymerase I transcription factor binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001082
type: Class
subclass of: transcription factor binding transcription factor activity

RNA polymerase II basal transcription factor binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001083
type: Class
subclass of: RNA polymerase II transcription factor binding transcription factor activity

TFIID-class binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has OBO namespace: molecular_function
id: GO:0001084
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

RNA polymerase II transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
has OBO namespace: molecular_function
id: GO:0001085
type: Class
subclass of: GO_0008134

TFIIA-class binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has OBO namespace: molecular_function
id: GO:0001086
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

TFIIB-class binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has OBO namespace: molecular_function
id: GO:0001087
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

TFIIE-class binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has OBO namespace: molecular_function
id: GO:0001088
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

TFIIF-class binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has OBO namespace: molecular_function
id: GO:0001089
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

TFIIH-class binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has OBO namespace: molecular_function
id: GO:0001090
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

RNA polymerase II basal transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001091
type: Class
subclass of: RNA polymerase II transcription factor binding
subclass of: basal RNA polymerase II transcription machinery binding

TFIIA-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001092
type: Class
subclass of: RNA polymerase II basal transcription factor binding

TFIIB-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001093
type: Class
subclass of: RNA polymerase II basal transcription factor binding

TFIID-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001094
type: Class
subclass of: RNA polymerase II basal transcription factor binding

TFIIE-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001095
type: Class
subclass of: RNA polymerase II basal transcription factor binding

TFIIF-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001096
type: Class
subclass of: RNA polymerase II basal transcription factor binding

TFIIH-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has OBO namespace: molecular_function
id: GO:0001097
type: Class
subclass of: RNA polymerase II basal transcription factor binding

basal transcription machinery binding
IAO_0000115: Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001098
type: Class
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
subclass of: GO_0005515

basal RNA polymerase II transcription machinery binding
IAO_0000115: Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001099
type: Class
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
subclass of: basal transcription machinery binding

negative regulation of exit from mitosis
IAO_0000115: Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
has exact synonym: down regulation of exit from mitosis
has exact synonym: down-regulation of exit from mitosis
has exact synonym: downregulation of exit from mitosis
has narrow synonym: inhibition of exit from mitosis
has OBO namespace: biological_process
id: GO:0001100
type: Class
subclass of: GO_0007096
subclass of: GO_0010948
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0010458

response to acid
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus.
has OBO namespace: biological_process
id: GO:0001101
type: Class
subclass of: GO_0042221

RNA polymerase II activating transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
has OBO namespace: molecular_function
id: GO:0001102
type: Class
subclass of: RNA polymerase II transcription factor binding
subclass of: GO_0033613

RNA polymerase II repressing transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
has OBO namespace: molecular_function
id: GO:0001103
type: Class
subclass of: RNA polymerase II transcription factor binding
subclass of: GO_0070491

RNA polymerase II transcription cofactor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
has alternative id: GO:0016455
has exact synonym: RNA polymerase II transcriptional co-regulator
has exact synonym: RNA polymerase II transcriptional cofactor activity
has OBO namespace: molecular_function
has related synonym: RNA polymerase II transcription mediator activity
has related synonym: TRAP protein
has related synonym: thyroid receptor-associated protein
id: GO:0001104
in subset: gosubset prok
type: Class
subclass of: RNA polymerase II transcription factor binding transcription factor activity
subclass of: transcription cofactor activity

RNA polymerase II transcription coactivator activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
has exact synonym: RNA polymerase II transcription co-activator activity
has OBO namespace: molecular_function
id: GO:0001105
in subset: gosubset prok
type: Class
comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
subclass of: RNA polymerase II transcription cofactor activity
subclass of: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
subclass of: transcription coactivator activity

RNA polymerase II transcription corepressor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
has exact synonym: RNA polymerase II transcription co-repressor activity
has OBO namespace: molecular_function
id: GO:0001106
type: Class
subclass of: RNA polymerase II transcription cofactor activity
subclass of: RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
subclass of: transcription corepressor activity

bacterial-type RNA polymerase holo enzyme binding
IAO_0000115: Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
has exact synonym: basal bacterial-type RNA polymerase transcription machinery binding
has OBO namespace: molecular_function
id: GO:0001108
in subset: gosubset prok
type: Class
subclass of: basal transcription machinery binding

promoter clearance during DNA-dependent transcription
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has broad synonym: promoter escape
has OBO namespace: biological_process
id: GO:0001109
type: Class
subclass of: GO_0032774
subclass of: Restriction
  on property: part_of
  some values from: GO_0006351

promoter clearance from RNA polymerase III promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase.
has OBO namespace: biological_process
id: GO:0001110
type: Class
subclass of: promoter clearance during DNA-dependent transcription
subclass of: Restriction
  on property: part_of
  some values from: GO_0006383

promoter clearance from RNA polymerase II promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has exact synonym: promoter escape from RNA polymerase II promoter
has OBO namespace: biological_process
id: GO:0001111
type: Class
subclass of: promoter clearance during DNA-dependent transcription
subclass of: Restriction
  on property: part_of
  some values from: GO_0006366

DNA-dependent transcriptional open complex formation
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has broad synonym: promoter melting
has OBO namespace: biological_process
id: GO:0001112
type: Class
subclass of: protein-DNA complex remodeling
subclass of: Restriction
  on property: part_of
  some values from: GO_0006352

transcriptional open complex formation at RNA polymerase II promoter
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: RNA polymerase II promoter melting
has OBO namespace: biological_process
id: GO:0001113
type: Class
subclass of: DNA-dependent transcriptional open complex formation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006367

protein-DNA-RNA complex
IAO_0000115: A macromolecular complex containing protein, DNA, and RNA molecules.
has OBO namespace: cellular_component
id: GO:0001114
type: Class
subclass of: GO_0032991

protein-DNA-RNA complex subunit organization
IAO_0000115: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex.
has exact synonym: protein-DNA-RNA complex subunit organisation
has OBO namespace: biological_process
id: GO:0001115
type: Class
subclass of: GO_0043933

protein-DNA-RNA complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.
has OBO namespace: biological_process
id: GO:0001116
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0034622

protein-DNA-RNA complex disassembly
IAO_0000115: The disaggregation of a protein-DNA-RNA complex into its constituent components.
has OBO namespace: biological_process
id: GO:0001117
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0032984

transcription ternary complex disassembly
IAO_0000115: The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components.
has exact synonym: transcription protein-DNA-RNA complex disassembly
has OBO namespace: biological_process
id: GO:0001118
type: Class
subclass of: protein-DNA-RNA complex disassembly
subclass of: Restriction
  on property: part_of
  some values from: GO_0006353

protein-DNA-RNA complex remodeling
IAO_0000115: The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex.
has OBO namespace: biological_process
id: GO:0001119
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0034367

protein-DNA complex remodeling
IAO_0000115: The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex.
has OBO namespace: biological_process
id: GO:0001120
type: Class
subclass of: GO_0034367
subclass of: GO_0071824

transcription from bacterial-type RNA polymerase promoter
IAO_0000115: The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter.
has OBO namespace: biological_process
id: GO:0001121
type: Class
subclass of: GO_0006351

promoter clearance from bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor.
has OBO namespace: biological_process
id: GO:0001122
type: Class
subclass of: promoter clearance during DNA-dependent transcription
subclass of: Restriction
  on property: part_of
  some values from: transcription from bacterial-type RNA polymerase promoter

transcription initiation from bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
has OBO namespace: biological_process
id: GO:0001123
type: Class
subclass of: GO_0006352
subclass of: Restriction
  on property: part_of
  some values from: transcription from bacterial-type RNA polymerase promoter

transcription elongation from bacterial-type RNA polymerase promoter
IAO_0000115: The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase.
has exact synonym: RNA elongation from bacterial-type RNA polymerase promoter
has OBO namespace: biological_process
id: GO:0001124
type: Class
subclass of: GO_0006354
subclass of: Restriction
  on property: part_of
  some values from: transcription from bacterial-type RNA polymerase promoter

transcription termination from bacterial-type RNA polymerase promoter
IAO_0000115: The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed.
has OBO namespace: biological_process
id: GO:0001125
type: Class
subclass of: GO_0006353
subclass of: Restriction
  on property: part_of
  some values from: transcription from bacterial-type RNA polymerase promoter

bacterial-type RNA polymerase preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
has exact synonym: bacterial-type RNA polymerase transcription PIC biosynthesis
has exact synonym: bacterial-type RNA polymerase transcription PIC formation
has exact synonym: bacterial-type RNA polymerase transcriptional preinitiation complex formation
has OBO namespace: biological_process
id: GO:0001126
type: Class
subclass of: GO_0070897
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from bacterial-type RNA polymerase promoter

transcriptional open complex formation at bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has OBO namespace: biological_process
id: GO:0001127
type: Class
subclass of: DNA-dependent transcriptional open complex formation
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from bacterial-type RNA polymerase promoter

RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
has OBO namespace: molecular_function
id: GO:0001128
type: Class
comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
subclass of: RNA polymerase II transcription coactivator activity

TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly
IAO_0000115: Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
has narrow synonym: TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly
has OBO namespace: molecular_function
id: GO:0001129
type: Class
comment: For example, both TFIIA as well as TFIIB interact with TBP bound to DNA to stabilize formation of the preinitiation complex.
subclass of: TBP-class protein binding RNA polymerase II transcription factor activity

sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001130
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001131
type: Class
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

TBP-class protein binding RNA polymerase II transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
has narrow synonym: TATA-binding protein binding RNA polymerase II transcription factor activity
has narrow synonym: TRF protein binding RNA polymerase II transcription factor activity
has OBO namespace: molecular_function
id: GO:0001132
type: Class
subclass of: RNA polymerase II basal transcription factor binding transcription factor activity

sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001133
type: Class
subclass of: sequence-specific DNA binding transcription factor recruiting transcription factor activity

transcription factor recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001134
type: Class
subclass of: transcription factor binding transcription factor activity

RNA polymerase II transcription factor recruiting transcription factor activity
IAO_0000115: The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001135
type: Class
subclass of: RNA polymerase II transcription factor binding transcription factor activity
subclass of: transcription factor recruiting transcription factor activity

TFIIE-class transcription factor recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIE-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001136
type: Class
subclass of: TFIIE-class binding transcription factor activity
subclass of: RNA polymerase II transcription factor recruiting transcription factor activity

TFIIF-class transcription factor recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIF-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001137
type: Class
subclass of: TFIIF-class binding transcription factor activity
subclass of: RNA polymerase II transcription factor recruiting transcription factor activity

TFIIH-class transcription factor recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001138
type: Class
subclass of: TFIIH-class binding transcription factor activity
subclass of: RNA polymerase II transcription factor recruiting transcription factor activity

core RNA polymerase II recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001139
type: Class
subclass of: core RNA polymerase II binding transcription factor activity

bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001140
type: Class
subclass of: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription

bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter.
has OBO namespace: molecular_function
id: GO:0001141
type: Class
subclass of: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription

sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001142
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence that is part of the core promoter for mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001143
type: Class
subclass of: sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity

mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001144
type: Class
subclass of: sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity

mitochondrial RNA polymerase termination site sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001145
type: Class
subclass of: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
subclass of: transcription termination site sequence-specific DNA binding

mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase in order to promote transcription termination by mitochondrial RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001146
type: Class
subclass of: sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity

transcription termination site sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0001147
type: Class
comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation.
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: transcription termination site DNA binding

bacterial-type RNA polymerase termination site sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001148
type: Class
subclass of: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
subclass of: transcription termination site sequence-specific DNA binding

bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase.
has OBO namespace: molecular_function
id: GO:0001149
type: Class
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

bacterial-type RNA polymerase enhancer sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences.
has exact synonym: bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding
has OBO namespace: molecular_function
id: GO:0001150
type: Class
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
subclass of: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
subclass of: enhancer sequence-specific DNA binding

bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a bacterial-type enhancer region in order to activate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences.
has OBO namespace: molecular_function
id: GO:0001151
type: Class
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity
IAO_0000115: The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter.
has exact synonym: type 1 RNA polymerase III promoter recognition
has OBO namespace: molecular_function
has related synonym: TFIIIA activity
id: GO:0001152
type: Class
comment: This represents TFIIIA.
subclass of: sequence-specific DNA binding transcription factor recruiting transcription factor activity
subclass of: RNA polymerase III transcription factor recruiting transcription factor activity

RNA polymerase III transcription factor recruiting transcription factor activity
IAO_0000115: The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III.
has OBO namespace: molecular_function
id: GO:0001153
type: Class
subclass of: RNA polymerase III transcription factor binding transcription factor activity
subclass of: transcription factor recruiting transcription factor activity

TFIIIB-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
has OBO namespace: molecular_function
id: GO:0001154
type: Class
subclass of: RNA polymerase III transcription factor binding

TFIIIA-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at type 1 promoters (5S genes) by RNA polymerase III.
has OBO namespace: molecular_function
id: GO:0001155
type: Class
subclass of: RNA polymerase III transcription factor binding

TFIIIC-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
has OBO namespace: molecular_function
id: GO:0001156
type: Class
subclass of: RNA polymerase III transcription factor binding

RNA polymerase III type 1 promoter TFIIIB recruiting transcription factor activity
IAO_0000115: The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC.
has OBO namespace: molecular_function
has related synonym: TFIIIC-type activity
id: GO:0001157
type: Class
comment: This represents TFIIIA.
subclass of: RNA polymerase III transcription factor recruiting transcription factor activity

enhancer sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
has OBO namespace: molecular_function
id: GO:0001158
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding
subclass of: GO_0035326

core promoter proximal region DNA binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0001159
type: Class
subclass of: GO_0044212

transcription termination site DNA binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
has OBO namespace: molecular_function
id: GO:0001160
type: Class
subclass of: GO_0044212

intronic transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within.
has OBO namespace: molecular_function
id: GO:0001161
type: Class
subclass of: GO_0044213

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.
has OBO namespace: molecular_function
id: GO:0001162
type: Class
subclass of: RNA polymerase II regulatory region sequence-specific DNA binding
subclass of: intronic transcription regulatory region sequence-specific DNA binding

RNA polymerase I regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I.
has OBO namespace: molecular_function
id: GO:0001163
type: Class
subclass of: RNA polymerase I regulatory region DNA binding

RNA polymerase I CORE element sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
has exact synonym: RNA polymerase I core element sequence-specific DNA binding
has exact synonym: RNA polymerase I core promoter sequence-specific DNA binding
has OBO namespace: molecular_function
id: GO:0001164
type: Class
subclass of: core promoter sequence-specific DNA binding
subclass of: RNA polymerase I regulatory region sequence-specific DNA binding

RNA polymerase I upstream control element sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I.
has OBO namespace: molecular_function
has related synonym: RNA polymerase I upstream element sequence-specific DNA binding
id: GO:0001165
type: Class
subclass of: core promoter proximal region sequence-specific DNA binding
subclass of: RNA polymerase I regulatory region sequence-specific DNA binding

RNA polymerase I enhancer sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
has OBO namespace: molecular_function
id: GO:0001166
type: Class
subclass of: enhancer sequence-specific DNA binding
subclass of: RNA polymerase I regulatory region sequence-specific DNA binding

sequence-specific DNA binding RNA polymerase I transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001167
type: Class
subclass of: sequence-specific DNA binding transcription factor activity

RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I.
has OBO namespace: molecular_function
id: GO:0001168
type: Class
subclass of: sequence-specific DNA binding RNA polymerase I transcription factor activity

RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I.
has exact synonym: RNA polymerase I core promoter sequence-specific DNA binding transcription factor
has OBO namespace: molecular_function
id: GO:0001169
type: Class
subclass of: sequence-specific DNA binding RNA polymerase I transcription factor activity

RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I.
has OBO namespace: molecular_function
id: GO:0001170
type: Class
subclass of: sequence-specific DNA binding RNA polymerase I transcription factor activity

reverse transcription
IAO_0000115: A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis.
has db xref: Wikipedia:Reverse_transcription
has OBO namespace: biological_process
id: GO:0001171
type: Class
subclass of: GO_0006278

transcription, RNA-dependent
IAO_0000115: The cellular synthesis of RNA on a template of RNA.
has OBO namespace: biological_process
id: GO:0001172
in subset: gosubset prok
type: Class
subclass of: GO_0032774

DNA-dependent transcriptional start site selection
IAO_0000115: Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has OBO namespace: biological_process
id: GO:0001173
type: Class
subclass of: GO_0032774
subclass of: Restriction
  on property: part_of
  some values from: GO_0006352

transcriptional start site selection at RNA polymerase II promoter
IAO_0000115: Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has OBO namespace: biological_process
id: GO:0001174
type: Class
subclass of: DNA-dependent transcriptional start site selection
subclass of: Restriction
  on property: part_of
  some values from: GO_0006367

transcriptional start site selection at RNA polymerase III promoter
IAO_0000115: Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has OBO namespace: biological_process
id: GO:0001175
type: Class
subclass of: DNA-dependent transcriptional start site selection
subclass of: Restriction
  on property: part_of
  some values from: GO_0006384

transcriptional start site selection at bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has OBO namespace: biological_process
id: GO:0001176
type: Class
subclass of: DNA-dependent transcriptional start site selection
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from bacterial-type RNA polymerase promoter

regulation of transcriptional open complex formation at RNA polymerase II promoter
IAO_0000115: Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has OBO namespace: biological_process
id: GO:0001177
type: Class
subclass of: GO_0060260
subclass of: Restriction
  on property: RO_0002211
  some values from: transcriptional open complex formation at RNA polymerase II promoter

regulation of transcriptional start site selection at RNA polymerase II promoter
IAO_0000115: Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has OBO namespace: biological_process
id: GO:0001178
type: Class
subclass of: GO_0060260
subclass of: Restriction
  on property: RO_0002211
  some values from: transcriptional start site selection at RNA polymerase II promoter

RNA polymerase I transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I.
has OBO namespace: molecular_function
id: GO:0001179
type: Class
subclass of: GO_0008134

transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
IAO_0000115: Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript, resulting in the subsequent synthesis of rRNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
has OBO namespace: biological_process
id: GO:0001180
type: Class
subclass of: GO_0006361
subclass of: Restriction
  on property: part_of
  some values from: GO_0042790

core RNA polymerase I binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase I (RNAP I) complex, typically composed of fourteen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001181
type: Class
subclass of: core RNA polymerase binding transcription factor activity

promoter clearance from RNA polymerase I promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has OBO namespace: biological_process
id: GO:0001182
type: Class
subclass of: promoter clearance during DNA-dependent transcription
subclass of: Restriction
  on property: part_of
  some values from: GO_0006360

transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript
IAO_0000115: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I.
has OBO namespace: biological_process
id: GO:0001183
type: Class
subclass of: GO_0006362
subclass of: Restriction
  on property: part_of
  some values from: GO_0042790

promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has OBO namespace: biological_process
id: GO:0001184
type: Class
subclass of: promoter clearance from RNA polymerase I promoter
subclass of: Restriction
  on property: part_of
  some values from: GO_0042790

termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript
IAO_0000115: The process in which the synthesis of an rRNA molecule from a promoter for the nuclear large ribosomal RNA (rRNA) transcript by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
has OBO namespace: biological_process
id: GO:0001185
type: Class
subclass of: GO_0006363
subclass of: Restriction
  on property: part_of
  some values from: GO_0042790

RNA polymerase I transcription factor recruiting transcription factor activity
IAO_0000115: The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I.
has OBO namespace: molecular_function
id: GO:0001186
type: Class
subclass of: RNA polymerase I transcription factor binding transcription factor activity
subclass of: transcription factor recruiting transcription factor activity

RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I.
has OBO namespace: molecular_function
id: GO:0001187
type: Class
subclass of: RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity
subclass of: RNA polymerase I transcription factor recruiting transcription factor activity

RNA polymerase I transcriptional preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.
has OBO namespace: biological_process
id: GO:0001188
type: Class
subclass of: GO_0070897
subclass of: Restriction
  on property: part_of
  some values from: GO_0006361

RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
IAO_0000115: The aggregation, arrangement and bonding together of proteins on CORE promoter element DNA of the nuclear large ribosomal RNA (rRNA) transcript to form a transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the large rRNA promoter, resulting in the subsequent synthesis of the large rRNA transcript.
has OBO namespace: biological_process
id: GO:0001189
type: Class
subclass of: RNA polymerase I transcriptional preinitiation complex assembly
subclass of: Restriction
  on property: part_of
  some values from: transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript

RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001190
type: Class
subclass of: RNA polymerase II transcription factor binding transcription factor activity

RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
has OBO namespace: molecular_function
id: GO:0001191
type: Class
subclass of: RNA polymerase II transcription factor binding transcription factor activity

maintenance of transcriptional fidelity during DNA-dependent transcription elongation
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template.
has OBO namespace: biological_process
id: GO:0001192
type: Class
subclass of: GO_0032774
subclass of: Restriction
  on property: part_of
  some values from: GO_0006354

maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.
has OBO namespace: biological_process
id: GO:0001193
type: Class
subclass of: maintenance of transcriptional fidelity during DNA-dependent transcription elongation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006368

maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter.
has OBO namespace: biological_process
id: GO:0001194
type: Class
subclass of: maintenance of transcriptional fidelity during DNA-dependent transcription elongation
subclass of: Restriction
  on property: part_of
  some values from: transcription elongation from bacterial-type RNA polymerase promoter

maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter.
has OBO namespace: biological_process
id: GO:0001195
type: Class
subclass of: maintenance of transcriptional fidelity during DNA-dependent transcription elongation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006385

regulation of mating-type specific transcription from RNA polymerase II promoter
IAO_0000115: Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has OBO namespace: biological_process
id: GO:0001196
type: Class
subclass of: GO_0006357
subclass of: GO_0007532

positive regulation of mating-type specific transcription from RNA polymerase II promoter
IAO_0000115: Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter.
has exact synonym: up regulation of transcription from an RNA polymerase II promoter, mating-type specific
has exact synonym: up-regulation of transcription from an RNA polymerase II promoter, mating-type specific
has exact synonym: upregulation of transcription from an RNA polymerase II promoter, mating-type specific
has narrow synonym: activation of transcription from an RNA polymerase II promoter, mating-type specific
has narrow synonym: stimulation of transcription from an RNA polymerase II promoter, mating-type specific
has OBO namespace: biological_process
id: GO:0001197
type: Class
subclass of: regulation of mating-type specific transcription from RNA polymerase II promoter
subclass of: GO_0045895

negative regulation of mating-type specific transcription from RNA polymerase II promoter
IAO_0000115: Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
has exact synonym: down regulation of RNA polymerase II transcription, mating-type specific
has exact synonym: down-regulation of RNA polymerase II transcription, mating-type specific
has exact synonym: downregulation of RNA polymerase II transcription, mating-type specific
has narrow synonym: inhibition of RNA polymerase II transcription, mating-type specific
has OBO namespace: biological_process
id: GO:0001198
type: Class
subclass of: regulation of mating-type specific transcription from RNA polymerase II promoter
subclass of: GO_0045894

metal ion regulated sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001199
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: sequence-specific DNA binding transcription factor activity

metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001200
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: sequence-specific DNA binding RNA polymerase II transcription factor activity
subclass of: metal ion regulated sequence-specific DNA binding transcription factor activity

metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor that binds the core promoter proximal region in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001201
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
subclass of: metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity

copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001202
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity

zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), in such a way that zinc ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II.
has OBO namespace: molecular_function
id: GO:0001203
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity

metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001204
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
subclass of: metal ion regulated sequence-specific DNA binding transcription factor activity

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
has exact synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has OBO namespace: molecular_function
id: GO:0001205
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
subclass of: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has exact synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
has OBO namespace: molecular_function
id: GO:0001206
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
subclass of: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

histone displacement
IAO_0000115: The removal of histones, including histone dimers, from nucleosomes within chromatin.
has OBO namespace: biological_process
id: GO:0001207
type: Class
subclass of: GO_0034728

histone H2A-H2B dimer displacement
IAO_0000115: The removal of a H2A-H2B histone dimer from a nucleosome within chromatin.
has OBO namespace: biological_process
id: GO:0001208
type: Class
subclass of: histone displacement

metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001209
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: metal ion regulated sequence-specific DNA binding transcription factor activity

metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001210
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: metal ion regulated sequence-specific DNA binding transcription factor activity

copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
has OBO namespace: molecular_function
id: GO:0001211
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
subclass of: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription

zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
has OBO namespace: molecular_function
id: GO:0001212
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
subclass of: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription

metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
has OBO namespace: molecular_function
id: GO:0001213
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
subclass of: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity

metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has OBO namespace: molecular_function
id: GO:0001214
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
subclass of: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity

metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001215
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
subclass of: metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001216
type: Class
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has OBO namespace: molecular_function
id: GO:0001217
type: Class
subclass of: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
has OBO namespace: molecular_function
id: GO:0001218
type: Class
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
subclass of: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
subclass of: metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), in such a way that copper ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase.
has OBO namespace: molecular_function
has related synonym: copper ion sensor
id: GO:0001219
type: Class
subclass of: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription

cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with cadmium (Cd) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd), in such a way that cadmium (Cd) ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase.
has OBO namespace: molecular_function
has related synonym: cadmium ion sensor
id: GO:0001220
type: Class
subclass of: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription

transcription cofactor binding
IAO_0000115: Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
has OBO namespace: molecular_function
id: GO:0001221
type: Class
subclass of: GO_0008134

transcription corepressor binding
IAO_0000115: Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
has OBO namespace: molecular_function
id: GO:0001222
type: Class
subclass of: transcription cofactor binding

transcription coactivator binding
IAO_0000115: Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
has OBO namespace: molecular_function
id: GO:0001223
type: Class
subclass of: transcription cofactor binding

RNA polymerase II transcription cofactor binding
IAO_0000115: Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II.
has OBO namespace: molecular_function
id: GO:0001224
type: Class
subclass of: transcription cofactor binding

RNA polymerase II transcription coactivator binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II.
has OBO namespace: molecular_function
id: GO:0001225
type: Class
subclass of: transcription coactivator binding
subclass of: RNA polymerase II transcription cofactor binding

RNA polymerase II transcription corepressor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.
has OBO namespace: molecular_function
id: GO:0001226
type: Class
subclass of: transcription corepressor binding
subclass of: RNA polymerase II transcription cofactor binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has OBO namespace: molecular_function
id: GO:0001227
type: Class
subclass of: sequence-specific DNA binding RNA polymerase II transcription factor activity

RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
has OBO namespace: molecular_function
id: GO:0001228
type: Class
subclass of: sequence-specific DNA binding RNA polymerase II transcription factor activity

chronological cell aging
IAO_0000115: The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
has exact synonym: chronological cell ageing
has OBO namespace: biological_process
id: GO:0001300
type: Class
subclass of: GO_0007569

progressive alteration of chromatin involved in cell aging
IAO_0000115: The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype.
has exact synonym: progressive alteration of chromatin during cell ageing
has OBO namespace: biological_process
has related synonym: age-dependent accumulation of genetic damage
has related synonym: progressive alteration of chromatin during cell aging
id: GO:0001301
type: Class
subclass of: GO_0016568
subclass of: Restriction
  on property: part_of
  some values from: GO_0007569

replicative cell aging
IAO_0000115: The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
has exact synonym: replicative cell ageing
has OBO namespace: biological_process
id: GO:0001302
type: Class
subclass of: GO_0007569

nucleolar fragmentation involved in replicative aging
IAO_0000115: A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells.
has OBO namespace: biological_process
has related synonym: nucleolar fragmentation during replicative ageing
has related synonym: nucleolar fragmentation during replicative aging
id: GO:0001303
type: Class
subclass of: GO_0007576
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging

progressive alteration of chromatin involved in replicative cell aging
IAO_0000115: A process that results in changes in chromatin structure contributing to replicative cell aging.
has exact synonym: progressive alteration of chromatin during replicative cell ageing
has OBO namespace: biological_process
has related synonym: progressive alteration of chromatin during replicative cell aging
id: GO:0001304
type: Class
subclass of: progressive alteration of chromatin involved in cell aging
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging

progressive alteration of chromatin involved in chronological cell aging
IAO_0000115: A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells.
has OBO namespace: biological_process
has related synonym: progressive alteration of chromatin during chronological cell ageing
has related synonym: progressive alteration of chromatin during chronological cell aging
id: GO:0001305
type: Class
subclass of: progressive alteration of chromatin involved in cell aging
subclass of: Restriction
  on property: part_of
  some values from: chronological cell aging

age-dependent response to oxidative stress
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism.
has OBO namespace: biological_process
id: GO:0001306
type: Class
subclass of: GO_0006979
subclass of: Restriction
  on property: part_of
  some values from: GO_0007571

extrachromosomal circular DNA accumulation involved in replicative cell aging
IAO_0000115: Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.
has OBO namespace: biological_process
has related synonym: extrachromosomal circular DNA accumulation during replicative cell ageing
has related synonym: extrachromosomal circular DNA accumulation during replicative cell aging
id: GO:0001307
type: Class
subclass of: progressive alteration of chromatin involved in replicative cell aging
subclass of: GO_0007580

negative regulation of chromatin silencing involved in replicative cell aging
IAO_0000115: The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins.
has exact synonym: loss of chromatin silencing involved in replicative cell aging
has OBO namespace: biological_process
has related synonym: loss of chromatin silencing during replicative cell ageing
id: GO:0001308
type: Class
subclass of: progressive alteration of chromatin involved in replicative cell aging
subclass of: GO_0031936
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0006342

age-dependent telomere shortening
IAO_0000115: Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process.
has OBO namespace: biological_process
id: GO:0001309
type: Class
subclass of: progressive alteration of chromatin involved in replicative cell aging
subclass of: GO_0010834

extrachromosomal rDNA circle accumulation involved in replicative cell aging
IAO_0000115: Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.
has OBO namespace: biological_process
has related synonym: extrachromosomal rDNA circle accumulation during replicative cell ageing
has related synonym: extrachromosomal rDNA circle accumulation during replicative cell aging
has related synonym: extrachromosomal ribosomal DNA circle accumulation during replicative cell aging
id: GO:0001310
type: Class
subclass of: extrachromosomal circular DNA accumulation involved in replicative cell aging

formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
IAO_0000115: Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age.
has OBO namespace: biological_process
has related synonym: assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
has related synonym: formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing
has related synonym: formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging
has related synonym: formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging
id: GO:0001311
type: Class
subclass of: formation of extrachromosomal circular DNA involved in replicative cell aging
subclass of: Restriction
  on property: part_of
  some values from: extrachromosomal rDNA circle accumulation involved in replicative cell aging

replication of extrachromosomal rDNA circles involved in replicative cell aging
IAO_0000115: Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication.
has OBO namespace: biological_process
has related synonym: replication of extrachromosomal rDNA circles during replicative cell ageing
has related synonym: replication of extrachromosomal rDNA circles during replicative cell aging
has related synonym: replication of extrachromosomal ribosomal DNA circles during replicative cell aging
id: GO:0001312
type: Class
subclass of: replication of extrachromosomal circular DNA involved in replicative cell aging
subclass of: Restriction
  on property: part_of
  some values from: extrachromosomal rDNA circle accumulation involved in replicative cell aging

formation of extrachromosomal circular DNA involved in replicative cell aging
IAO_0000115: Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age.
has exact synonym: assembly of extrachromosomal circular DNA involved in replicative cell aging
has OBO namespace: biological_process
has related synonym: formation of extrachromosomal circular DNA during replicative cell ageing
has related synonym: formation of extrachromosomal circular DNA during replicative cell aging
id: GO:0001313
type: Class
subclass of: formation of extrachromosomal circular DNA
subclass of: Restriction
  on property: part_of
  some values from: extrachromosomal circular DNA accumulation involved in replicative cell aging
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging

replication of extrachromosomal circular DNA involved in replicative cell aging
IAO_0000115: Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.
has exact synonym: replication of extrachromosomal circular DNA during replicative cell ageing
has OBO namespace: biological_process
has related synonym: replication of extrachromosomal circular DNA during replicative cell aging
id: GO:0001314
type: Class
subclass of: replication of extrachromosomal circular DNA
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging
subclass of: Restriction
  on property: part_of
  some values from: extrachromosomal circular DNA accumulation involved in replicative cell aging

age-dependent response to reactive oxygen species
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
has exact synonym: age-dependent response to AOS
has exact synonym: age-dependent response to ROI
has exact synonym: age-dependent response to ROS
has exact synonym: age-dependent response to active oxygen species
has exact synonym: age-dependent response to reactive oxidative species
has exact synonym: age-dependent response to reactive oxygen intermediate
has OBO namespace: biological_process
id: GO:0001315
in subset: gosubset prok
type: Class
subclass of: response to reactive oxygen species
subclass of: age-dependent response to oxidative stress

age-dependent response to reactive oxygen species involved in replicative cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
has exact synonym: age-dependent response to AOS during replicative cell aging
has exact synonym: age-dependent response to reactive oxidative species during replicative cell aging
has exact synonym: age-dependent response to reactive oxygen species during replicative cell ageing
has OBO namespace: biological_process
has related synonym: age-dependent response to ROI during replicative cell aging
has related synonym: age-dependent response to ROS during replicative cell aging
has related synonym: age-dependent response to active oxygen species during replicative cell aging
has related synonym: age-dependent response to reactive oxygen intermediate during replicative cell aging
has related synonym: age-dependent response to reactive oxygen species during replicative cell aging
id: GO:0001316
type: Class
subclass of: age-dependent response to oxidative stress involved in replicative cell aging
subclass of: GO_0072353
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging

accumulation of oxidatively modified proteins involved in replicative cell aging
IAO_0000115: Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.
has OBO namespace: biological_process
has related synonym: accumulation of oxidatively modified proteins during replicative cell ageing
has related synonym: accumulation of oxidatively modified proteins during replicative cell aging
id: GO:0001317
type: Class
subclass of: age-dependent response to reactive oxygen species involved in replicative cell aging

formation of oxidatively modified proteins involved in replicative cell aging
IAO_0000115: Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.
has OBO namespace: biological_process
has related synonym: formation of oxidatively modified proteins during replicative cell ageing
has related synonym: formation of oxidatively modified proteins during replicative cell aging
id: GO:0001318
type: Class
subclass of: GO_0006464
subclass of: Restriction
  on property: part_of
  some values from: accumulation of oxidatively modified proteins involved in replicative cell aging

inheritance of oxidatively modified proteins involved in replicative cell aging
IAO_0000115: A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells.
has OBO namespace: biological_process
has related synonym: inheritance of oxidatively modified proteins during replicative cell ageing
has related synonym: inheritance of oxidatively modified proteins during replicative cell aging
id: GO:0001319
type: Class
subclass of: GO_0008105
subclass of: Restriction
  on property: part_of
  some values from: accumulation of oxidatively modified proteins involved in replicative cell aging

age-dependent response to reactive oxygen species involved in chronological cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
has OBO namespace: biological_process
has related synonym: age-dependent response to AOS during chronological cell aging
has related synonym: age-dependent response to ROI during chronological cell aging
has related synonym: age-dependent response to ROS during chronological cell aging
has related synonym: age-dependent response to active oxygen species during chronological cell aging
has related synonym: age-dependent response to reactive oxidative species during chronological cell aging
has related synonym: age-dependent response to reactive oxygen intermediate during chronological cell aging
has related synonym: age-dependent response to reactive oxygen species during chronological cell ageing
has related synonym: age-dependent response to reactive oxygen species during chronological cell aging
id: GO:0001320
type: Class
subclass of: age-dependent response to oxidative stress involved in chronological cell aging
subclass of: GO_0072353
subclass of: Restriction
  on property: part_of
  some values from: chronological cell aging

age-dependent general metabolic decline involved in replicative cell aging
IAO_0000115: A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.
has OBO namespace: biological_process
has related synonym: age-dependent general metabolic decline during replicative cell ageing
has related synonym: age-dependent general metabolic decline involved in replicative cell aging
id: GO:0001321
type: Class
subclass of: GO_0007571
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging

age-dependent response to oxidative stress involved in replicative cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.
has OBO namespace: biological_process
has related synonym: age-dependent response to oxidative stress during replicative cell ageing
has related synonym: age-dependent response to oxidative stress during replicative cell aging
id: GO:0001322
type: Class
subclass of: age-dependent response to oxidative stress
subclass of: GO_0034599
subclass of: Restriction
  on property: part_of
  some values from: age-dependent general metabolic decline involved in replicative cell aging
subclass of: Restriction
  on property: part_of
  some values from: replicative cell aging

age-dependent general metabolic decline involved in chronological cell aging
IAO_0000115: A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.
has OBO namespace: biological_process
has related synonym: age-dependent general metabolic decline during chronological cell ageing
has related synonym: age-dependent general metabolic decline during chronological cell aging
id: GO:0001323
type: Class
subclass of: GO_0007571
subclass of: Restriction
  on property: part_of
  some values from: chronological cell aging

age-dependent response to oxidative stress involved in chronological cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.
has OBO namespace: biological_process
has related synonym: age-dependent response to oxidative stress during chronological cell ageing
has related synonym: age-dependent response to oxidative stress during chronological cell aging
id: GO:0001324
type: Class
subclass of: age-dependent response to oxidative stress
subclass of: GO_0034599
subclass of: Restriction
  on property: part_of
  some values from: age-dependent general metabolic decline involved in chronological cell aging
subclass of: Restriction
  on property: part_of
  some values from: chronological cell aging

formation of extrachromosomal circular DNA
IAO_0000115: Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats.
has exact synonym: assembly of extrachromosomal circular DNA
has OBO namespace: biological_process
id: GO:0001325
in subset: gosubset prok
type: Class
subclass of: GO_0006259
subclass of: GO_0022607

replication of extrachromosomal circular DNA
IAO_0000115: Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.
has OBO namespace: biological_process
id: GO:0001326
in subset: gosubset prok
type: Class
subclass of: GO_0006260

mating projection base
IAO_0000115: The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone.
has narrow synonym: base of shmoo tip
has narrow synonym: conjugation tube base
has OBO namespace: cellular_component
id: GO:0001400
type: Class
subclass of: GO_0044463
subclass of: Restriction
  on property: part_of
  some values from: GO_0005937

mitochondrial sorting and assembly machinery complex
IAO_0000115: A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.
has exact synonym: SAM complex
has exact synonym: TOB complex
has OBO namespace: cellular_component
id: GO:0001401
type: Class
comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
subclass of: GO_0043234
subclass of: GO_0044455
subclass of: Restriction
  on property: part_of
  some values from: GO_0005741

signal transduction involved in filamentous growth
IAO_0000115: Relaying of environmental signals promoting filamentous growth.
has OBO namespace: biological_process
has related synonym: MAPKKK cascade (pseudohyphal growth)
has related synonym: signal transduction during filamentous growth
id: GO:0001402
type: Class
subclass of: GO_0007165
subclass of: Restriction
  on property: part_of
  some values from: GO_0030447

invasive growth in response to glucose limitation
IAO_0000115: A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
has OBO namespace: biological_process
has related synonym: colony morphology
id: GO:0001403
in subset: goslim yeast
type: Class
comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO.
subclass of: GO_0036267

invasive growth
IAO_0000115: OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue.
consider: GO:0044409
has exact synonym: tissue invasion
has OBO namespace: biological_process
id: GO:0001404
type: Class
comment: This term was made obsolete because more appropriate terms were created.
deprecated: true

presequence translocase-associated import motor
IAO_0000115: Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix.
has exact synonym: PAM complex
has exact synonym: mitochondrial import motor
has exact synonym: pre-sequence translocase-associated import motor
has OBO namespace: cellular_component
id: GO:0001405
type: Class
subclass of: GO_0043234
subclass of: GO_0044455
subclass of: Restriction
  on property: part_of
  some values from: GO_0005744

glycerophosphodiester transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.
has OBO namespace: molecular_function
id: GO:0001406
type: Class
subclass of: GO_0015605

glycerophosphodiester transport
IAO_0000115: The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.
has OBO namespace: biological_process
id: GO:0001407
type: Class
subclass of: GO_0015711
subclass of: GO_0015748
subclass of: GO_1901264

guanine nucleotide transport
IAO_0000115: The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has OBO namespace: biological_process
id: GO:0001408
type: Class
subclass of: GO_0015858
subclass of: GO_0015868

guanine nucleotide transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other.
has OBO namespace: molecular_function
id: GO:0001409
type: Class
subclass of: GO_0015216

chlamydospore formation
IAO_0000115: The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans.
has alternative id: GO:0055027
has exact synonym: chlamydospore development
has OBO namespace: biological_process
id: GO:0001410
type: Class
subclass of: GO_0043936
subclass of: GO_0048468

hyphal tip
IAO_0000115: The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
has OBO namespace: cellular_component
id: GO:0001411
in subset: goslim candida
type: Class
subclass of: GO_0030427

skeletal system development
IAO_0000115: The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
has exact synonym: skeletal development
has OBO namespace: biological_process
id: GO:0001501
type: Class
subclass of: GO_0048731

cartilage condensation
IAO_0000115: The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
has OBO namespace: biological_process
id: GO:0001502
type: Class
subclass of: GO_0016337
subclass of: Restriction
  on property: part_of
  some values from: GO_0051216
subclass of: Restriction
  on property: part_of
  some values from: GO_0048705

ossification
IAO_0000115: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
has db xref: Wikipedia:Ossification
has exact synonym: bone biosynthesis
has exact synonym: bone formation
has exact synonym: osteogenesis
has OBO namespace: biological_process
id: GO:0001503
type: Class
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
subclass of: GO_0044707

neurotransmitter uptake
IAO_0000115: The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft.
has broad synonym: neurotransmitter recycling
has db xref: Reactome:REACT_106095
has db xref: Reactome:REACT_106673
has db xref: Reactome:REACT_107830
has db xref: Reactome:REACT_114027
has db xref: Reactome:REACT_13594
has db xref: Reactome:REACT_29399
has db xref: Reactome:REACT_30311
has db xref: Reactome:REACT_82534
has db xref: Reactome:REACT_88126
has db xref: Reactome:REACT_89424
has db xref: Reactome:REACT_92363
has db xref: Reactome:REACT_93291
has db xref: Reactome:REACT_94616
has db xref: Reactome:REACT_97761
has db xref: Reactome:REACT_98224
has db xref: Reactome:REACT_98482
has db xref: Reactome:REACT_98978
has db xref: Reactome:REACT_99735
has exact synonym: neurotransmitter import
has exact synonym: neurotransmitter reuptake
has narrow synonym: neurotransmitter import into glial cell
has narrow synonym: neurotransmitter import into neuron
has OBO namespace: biological_process
id: GO:0001504
type: Class
subclass of: regulation of neurotransmitter levels
subclass of: GO_0006836

regulation of neurotransmitter levels
IAO_0000115: Any process that modulates levels of neurotransmitter.
has OBO namespace: biological_process
id: GO:0001505
type: Class
subclass of: GO_0065008
subclass of: Restriction
  on property: part_of
  some values from: GO_0007268

neurotransmitter biosynthetic process and storage
IAO_0000115: OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules.
consider: GO:0042136
consider: GO:0042137
has exact synonym: neurotransmitter anabolism and storage
has exact synonym: neurotransmitter formation and storage
has exact synonym: neurotransmitter synthesis and storage
has OBO namespace: biological_process
id: GO:0001506
type: Class
comment: This term was made obsolete because it is an amalgamation of its two children.
deprecated: true

acetylcholine catabolic process in synaptic cleft
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.
has exact synonym: acetylcholine breakdown in synaptic cleft
has exact synonym: acetylcholine degradation in synaptic cleft
has OBO namespace: biological_process
id: GO:0001507
type: Class
subclass of: GO_0006581
subclass of: Restriction
  on property: part_of
  some values from: GO_0007271

regulation of action potential
IAO_0000115: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.
has OBO namespace: biological_process
id: GO:0001508
type: Class
subclass of: GO_0042391

legumain activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.
IAO_0100001: GO:0004197
has db xref: EC:3.4.22.34
has db xref: MetaCyc:3.4.22.34-RXN
has OBO namespace: molecular_function
has related synonym: PRSC1 gene product (Homo sapiens)
has related synonym: asparaginyl endopeptidase activity
has related synonym: bean endopeptidase activity
has related synonym: citvac
has related synonym: hemoglobinase activity
has related synonym: phaseolin activity
has related synonym: proteinase B
has related synonym: vicilin peptidohydrolase activity
id: GO:0001509
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

RNA methylation
IAO_0000115: Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
has OBO namespace: biological_process
id: GO:0001510
in subset: gosubset prok
type: Class
subclass of: GO_0009451
subclass of: GO_0043414

fibrillin
IAO_0000115: OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome.
consider: GO:0001527
consider: GO:0005509
has OBO namespace: molecular_function
id: GO:0001511
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

dihydronicotinamide riboside quinone reductase activity
IAO_0000115: Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
has db xref: EC:1.10.99.2
has db xref: MetaCyc:1.10.99.2-RXN
has exact synonym: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity
has exact synonym: N-ribosyldihydronicotinamide dehydrogenase (quinone) activity
has exact synonym: NAD(P)H:quinone oxidoreductase 2 activity
has exact synonym: NQO(2) activity
has exact synonym: ribosyldihydronicotinamide dehydrogenase (quinone) activity
has narrow synonym: NRH:quinone oxidoreductase 2 activity
has OBO namespace: molecular_function
has related synonym: NAD(P)H:quinone oxidoreductase-2
has related synonym: NAD(P)H:quinone oxidoreductase2
has related synonym: NQO2
has related synonym: QR2 activity
has related synonym: quinone reductase 2 activity
id: GO:0001512
type: Class
subclass of: GO_0016491

selenocysteine incorporation
IAO_0000115: The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.
has db xref: RESID:AA0022
has OBO namespace: biological_process
id: GO:0001514
in subset: gosubset prok
type: Class
subclass of: GO_0006451

opioid peptide activity
IAO_0000115: Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.
has OBO namespace: molecular_function
id: GO:0001515
type: Class
subclass of: GO_0005102

prostaglandin biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
has exact synonym: prostaglandin anabolism
has exact synonym: prostaglandin biosynthesis
has exact synonym: prostaglandin formation
has exact synonym: prostaglandin synthesis
has OBO namespace: biological_process
id: GO:0001516
in subset: gosubset prok
type: Class
subclass of: GO_0006693
subclass of: GO_0046457

N-acetylglucosamine 6-O-sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.
has db xref: EC:2.8.2.-
has exact synonym: N-acetylglucosamine 6-O-sulphotransferase activity
has OBO namespace: molecular_function
id: GO:0001517
type: Class
subclass of: GO_0008146

voltage-gated sodium channel complex
IAO_0000115: A sodium channel in a cell membrane whose opening is governed by the membrane potential.
has db xref: NIF_Subcellular:sao785001660
has exact synonym: voltage gated sodium channel complex
has exact synonym: voltage-dependent sodium channel complex
has exact synonym: voltage-sensitive sodium channel complex
has OBO namespace: cellular_component
id: GO:0001518
type: Class
subclass of: GO_0034706
subclass of: GO_0044459
subclass of: Restriction
  on property: part_of
  some values from: GO_0005887

peptide amidation
IAO_0000115: The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions.
has OBO namespace: biological_process
id: GO:0001519
in subset: gosubset prok
type: Class
subclass of: GO_0031179

outer dense fiber
IAO_0000115: Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile.
has exact synonym: outer dense fibre
has OBO namespace: cellular_component
id: GO:0001520
type: Class
subclass of: GO_0044447

pseudouridine synthesis
IAO_0000115: The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.
has db xref: Wikipedia:Pseudouridine
has db xref: Wikipedia:Pseudouridylation
has exact synonym: pseudouridylation
has OBO namespace: biological_process
id: GO:0001522
in subset: gosubset prok
type: Class
subclass of: GO_0009451

retinoid metabolic process
IAO_0000115: The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
has db xref: Reactome:REACT_24968
has exact synonym: retinoid metabolism
has OBO namespace: biological_process
id: GO:0001523
in subset: gosubset prok
type: Class
subclass of: GO_0016101

globin
IAO_0000115: OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins.
IAO_0100001: GO:0005344
has OBO namespace: molecular_function
id: GO:0001524
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

angiogenesis
IAO_0000115: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
has db xref: Wikipedia:Angiogenesis
has exact synonym: blood vessel formation from pre-existing blood vessels
has OBO namespace: biological_process
id: GO:0001525
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0048514

proteoglycan sulfate transfer
IAO_0000115: OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate.
consider: GO:0006029
consider: GO:0006790
consider: GO:0050698
has exact synonym: proteoglycan sulphate transfer
has OBO namespace: biological_process
id: GO:0001526
type: Class
comment: This term was made obsolete because it represents a group of molecular functions.
deprecated: true

microfibril
IAO_0000115: Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
has exact synonym: extended fibrils
has OBO namespace: cellular_component
has related synonym: fibrillin
id: GO:0001527
type: Class
subclass of: GO_0043205

elastin
IAO_0000115: OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues.
IAO_0100001: GO:0030023
has OBO namespace: molecular_function
id: GO:0001528
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

elastin
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0030023
has OBO namespace: cellular_component
id: GO:0001529
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

lipopolysaccharide binding
IAO_0000115: Interacting selectively and non-covalently with lipopolysaccharide.
has broad synonym: endotoxin binding
has exact synonym: LPS binding
has OBO namespace: molecular_function
id: GO:0001530
type: Class
subclass of: GO_0008289

interleukin-21 receptor binding
IAO_0000115: Interacting selectively and non-covalently with the interleukin-21 receptor.
has narrow synonym: IL-21
has narrow synonym: interleukin-21 receptor ligand
has OBO namespace: molecular_function
id: GO:0001531
type: Class
subclass of: GO_0005126

interleukin-21 receptor activity
IAO_0000115: Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: IL-21 receptor activity
has exact synonym: IL-21R
has OBO namespace: molecular_function
id: GO:0001532
type: Class
subclass of: GO_0004896

cornified envelope
IAO_0000115: An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells.
has OBO namespace: cellular_component
id: GO:0001533
type: Class
subclass of: GO_0005856

radial spoke
IAO_0000115: Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.
has db xref: Wikipedia:Radial_spoke
has OBO namespace: cellular_component
id: GO:0001534
in subset: goslim pir
type: Class
subclass of: GO_0043234
subclass of: GO_0044447

radial spokehead
IAO_0000115: Protein complex forming part of eukaryotic flagellar apparatus.
has OBO namespace: cellular_component
id: GO:0001535
type: Class
subclass of: GO_0043234
subclass of: GO_0044447
subclass of: Restriction
  on property: part_of
  some values from: radial spoke

radial spoke stalk
IAO_0000115: Globular portion of the radial spoke that projects towards the central pair of microtubules.
has OBO namespace: cellular_component
id: GO:0001536
type: Class
subclass of: GO_0043234
subclass of: GO_0044447
subclass of: Restriction
  on property: part_of
  some values from: radial spoke

N-acetylgalactosamine 4-O-sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.
has db xref: EC:2.8.2.-
has exact synonym: N-acetylgalactosamine 4-O-sulphotransferase activity
has OBO namespace: molecular_function
id: GO:0001537
type: Class
subclass of: GO_0008146

ciliary or flagellar motility
IAO_0000115: Cell motility due to movement of cilia or flagella.
has exact synonym: ciliary/flagellar motility
has OBO namespace: biological_process
id: GO:0001539
in subset: gosubset prok
type: Class
subclass of: GO_0048870

beta-amyloid binding
IAO_0000115: Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor.
has OBO namespace: molecular_function
id: GO:0001540
type: Class
subclass of: GO_0042277

ovarian follicle development
IAO_0000115: The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
has OBO namespace: biological_process
has related synonym: follicular phase
id: GO:0001541
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: GO_0008585

ovulation from ovarian follicle
IAO_0000115: The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.
has OBO namespace: biological_process
id: GO:0001542
type: Class
subclass of: GO_0022602
subclass of: GO_0030728
subclass of: Restriction
  on property: part_of
  some values from: GO_0008585

ovarian follicle rupture
IAO_0000115: Disruption of theca cell layer releasing follicular fluid and/or the oocyte.
has OBO namespace: biological_process
id: GO:0001543
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: ovulation from ovarian follicle

initiation of primordial ovarian follicle growth
IAO_0000115: Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle).
has OBO namespace: biological_process
id: GO:0001544
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: ovarian follicle development

primary ovarian follicle growth
IAO_0000115: Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).
has OBO namespace: biological_process
id: GO:0001545
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: ovarian follicle development

preantral ovarian follicle growth
IAO_0000115: Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation.
has OBO namespace: biological_process
id: GO:0001546
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: GO_0048162
subclass of: Restriction
  on property: part_of
  some values from: ovarian follicle development

antral ovarian follicle growth
IAO_0000115: Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.
has OBO namespace: biological_process
id: GO:0001547
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0022602
subclass of: GO_0048589
subclass of: Restriction
  on property: part_of
  some values from: ovarian follicle development

follicular fluid formation in ovarian follicle antrum
IAO_0000115: The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis.
has exact synonym: ovarian follicle antrum/follicular fluid biosynthesis
has exact synonym: ovarian follicle antrum/follicular fluid formation
has OBO namespace: biological_process
id: GO:0001548
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: antral ovarian follicle growth

cumulus cell differentiation
IAO_0000115: The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.
has exact synonym: ovarian cumulus cell differentiation
has OBO namespace: biological_process
id: GO:0001549
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0030154
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0048165
subclass of: Restriction
  on property: part_of
  some values from: antral ovarian follicle growth

ovarian cumulus expansion
IAO_0000115: Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.
has OBO namespace: biological_process
has related synonym: ovarian cumulus growth
id: GO:0001550
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: antral ovarian follicle growth
subclass of: Restriction
  on property: part_of
  some values from: GO_0048165

ovarian follicle endowment
IAO_0000115: Association of oocytes with supporting epithelial granulosa cells to form primordial follicles.
has OBO namespace: biological_process
id: GO:0001551
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: ovarian follicle development

ovarian follicle atresia
IAO_0000115: A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed.
has OBO namespace: biological_process
id: GO:0001552
type: Class
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0008585

luteinization
IAO_0000115: The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
has db xref: Wikipedia:Luteal_phase
has db xref: Wikipedia:Luteinization
has OBO namespace: biological_process
has related synonym: luteal phase
id: GO:0001553
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: GO_0008585

luteolysis
IAO_0000115: The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.
has db xref: Wikipedia:Luteolysis
has OBO namespace: biological_process
id: GO:0001554
type: Class
subclass of: GO_0022602
subclass of: Restriction
  on property: part_of
  some values from: GO_0008585

oocyte growth
IAO_0000115: The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
has OBO namespace: biological_process
id: GO:0001555
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0048588
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0048599

oocyte maturation
IAO_0000115: A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
has db xref: Wikipedia:Oocyte_maturation
has OBO namespace: biological_process
id: GO:0001556
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0048469
subclass of: GO_0048610
subclass of: Restriction
  on property: part_of
  some values from: GO_0048599

metabolic process resulting in cell growth
IAO_0000115: OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell.
IAO_0100001: GO:0008152
IAO_0100001: GO:0016049
has OBO namespace: biological_process
id: GO:0001557
type: Class
comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms.
deprecated: true

regulation of cell growth
IAO_0000115: Any process that modulates the frequency, rate, extent or direction of cell growth.
has db xref: Reactome:REACT_6201
has OBO namespace: biological_process
id: GO:0001558
in subset: gosubset prok
type: Class
subclass of: GO_0040008
subclass of: GO_0051128
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0016049

regulation of cell growth by detection of nuclear:cytoplasmic ratio
IAO_0000115: Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
has exact synonym: detection of nuclear:cytoplasmic ratio to regulate cell growth
has exact synonym: interpretation of nuclear:cytoplasmic ratio to regulate cell growth
has exact synonym: regulation of cell growth by nuclear:cytoplasmic ratio
has exact synonym: regulation of cell growth by sensing of nuclear:cytoplasmic ratio
has OBO namespace: biological_process
id: GO:0001559
type: Class
subclass of: GO_0016475
subclass of: GO_0061387

regulation of cell growth by extracellular stimulus
IAO_0000115: Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
has exact synonym: interpretation of external signals that regulate cell growth
has exact synonym: regulation of cell growth by detection of exogenous stimulus
has exact synonym: regulation of cell growth by sensing of exogenous stimulus
has exact synonym: regulation of growth by exogenous signal
has exact synonym: regulation of growth by exogenous stimuli
has exact synonym: regulation of growth by exogenous stimulus
has exact synonym: regulation of growth by external signal
has exact synonym: regulation of growth by external stimuli
has exact synonym: regulation of growth by external stimulus
has OBO namespace: biological_process
id: GO:0001560
type: Class
subclass of: regulation of cell growth
subclass of: Restriction
  on property: part_of
  some values from: GO_0031668

fatty acid alpha-oxidation
IAO_0000115: A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
has db xref: MetaCyc:PWY-2501
has db xref: Reactome:REACT_103076
has db xref: Reactome:REACT_106518
has db xref: Reactome:REACT_106956
has db xref: Reactome:REACT_107335
has db xref: Reactome:REACT_109097
has db xref: Reactome:REACT_17003
has db xref: Reactome:REACT_29885
has db xref: Reactome:REACT_47735
has db xref: Reactome:REACT_78088
has db xref: Reactome:REACT_81097
has db xref: Reactome:REACT_83317
has db xref: Reactome:REACT_87622
has db xref: Reactome:REACT_87835
has db xref: Reactome:REACT_90750
has db xref: Reactome:REACT_92361
has db xref: Reactome:REACT_94726
has db xref: Reactome:REACT_94872
has db xref: Reactome:REACT_96409
has db xref: Reactome:REACT_98637
has OBO namespace: biological_process
id: GO:0001561
in subset: gosubset prok
type: Class
subclass of: GO_0009062
subclass of: GO_0019395

response to protozoan
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
has alternative id: GO:0042833
has exact synonym: response to protozoa
has exact synonym: response to protozoon
has OBO namespace: biological_process
has related synonym: resistance to pathogenic protozoa
id: GO:0001562
type: Class
subclass of: GO_0051707

detection of protozoan
IAO_0000115: The series of events in which a stimulus from a protozoan is received and converted into a molecular signal.
has exact synonym: detection of protozoa
has exact synonym: detection of protozoon
has OBO namespace: biological_process
has related synonym: perception of protozoa
id: GO:0001563
type: Class
subclass of: response to protozoan
subclass of: GO_0009581
subclass of: GO_0009595

resistance to pathogenic protozoa
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0001562
has OBO namespace: biological_process
id: GO:0001564
type: Class
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
deprecated: true

phorbol ester receptor activity
IAO_0000115: Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001565
type: Class
subclass of: GO_0038023

non-kinase phorbol ester receptor activity
IAO_0000115: Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.
has OBO namespace: molecular_function
id: GO:0001566
type: Class
subclass of: phorbol ester receptor activity

cholesterol 25-hydroxylase activity
IAO_0000115: Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O.
has db xref: EC:1.14.99.38
has db xref: KEGG:R07218
has db xref: MetaCyc:1.14.99.38-RXN
has db xref: RHEA:21107
has exact synonym: cholesterol 25-monooxygenase activity
has exact synonym: cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity
has OBO namespace: molecular_function
id: GO:0001567
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

blood vessel development
IAO_0000115: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
has OBO namespace: biological_process
id: GO:0001568
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: vasculature development

patterning of blood vessels
IAO_0000115: The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
has exact synonym: branching involved in blood vessel morphogenesis
has OBO namespace: biological_process
id: GO:0001569
type: Class
subclass of: GO_0007389
subclass of: GO_0048754
subclass of: GO_0061138
subclass of: Restriction
  on property: part_of
  some values from: angiogenesis

vasculogenesis
IAO_0000115: The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
has db xref: Wikipedia:Vasculogenesis
has exact synonym: vascular morphogenesis
has OBO namespace: biological_process
id: GO:0001570
type: Class
subclass of: GO_0030154
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0048514

non-tyrosine kinase fibroblast growth factor receptor activity
IAO_0000115: Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity.
has exact synonym: non-tyrosine kinase FGF receptor activity
has exact synonym: non-tyrosine kinase FGFR activity
has OBO namespace: molecular_function
id: GO:0001571
type: Class
subclass of: GO_0004888

lactosylceramide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides.
has exact synonym: lactosylceramide anabolism
has exact synonym: lactosylceramide biosynthesis
has exact synonym: lactosylceramide formation
has exact synonym: lactosylceramide synthesis
has OBO namespace: biological_process
id: GO:0001572
in subset: gosubset prok
type: Class
subclass of: GO_0006688
subclass of: GO_0046478
subclass of: GO_0046513

ganglioside metabolic process
IAO_0000115: The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
has exact synonym: ganglioside metabolism
has OBO namespace: biological_process
id: GO:0001573
in subset: gosubset prok
type: Class
subclass of: GO_0006672
subclass of: GO_0006687

ganglioside biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
has exact synonym: ganglioside anabolism
has exact synonym: ganglioside biosynthesis
has exact synonym: ganglioside formation
has exact synonym: ganglioside synthesis
has OBO namespace: biological_process
id: GO:0001574
in subset: gosubset prok
type: Class
subclass of: ganglioside metabolic process
subclass of: GO_0006688
subclass of: GO_0046513

globoside metabolic process
IAO_0000115: The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
has exact synonym: globoside metabolism
has OBO namespace: biological_process
id: GO:0001575
in subset: gosubset prok
type: Class
subclass of: GO_0006687

globoside biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).
has exact synonym: globoside anabolism
has exact synonym: globoside biosynthesis
has exact synonym: globoside formation
has exact synonym: globoside synthesis
has OBO namespace: biological_process
id: GO:0001576
in subset: gosubset prok
type: Class
subclass of: globoside metabolic process
subclass of: GO_0006688

galectin
IAO_0000115: OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars.
consider: GO:0007157
consider: GO:0016936
has exact synonym: S-type lectin
has OBO namespace: molecular_function
id: GO:0001577
type: Class
comment: This term was made obsolete because it refers to a class of gene products.
deprecated: true

microtubule bundle formation
IAO_0000115: A process that results in a parallel arrangement of microtubules.
has exact synonym: microtubule bundling
has OBO namespace: biological_process
id: GO:0001578
type: Class
subclass of: microtubule cytoskeleton organization

medium-chain fatty acid transport
IAO_0000115: The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.
has OBO namespace: biological_process
id: GO:0001579
type: Class
subclass of: GO_0015908

detection of chemical stimulus involved in sensory perception of bitter taste
IAO_0000115: The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
has exact synonym: bitter taste detection
has exact synonym: perception of bitter taste, detection of chemical stimulus
has exact synonym: perception of bitter taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of bitter taste
has exact synonym: sensory detection of chemical stimulus during perception of bitter taste
has exact synonym: sensory transduction of bitter taste
has exact synonym: sensory transduction of chemical stimulus during perception of bitter taste
has OBO namespace: biological_process
id: GO:0001580
type: Class
subclass of: GO_0050912
subclass of: Restriction
  on property: part_of
  some values from: GO_0050913

detection of chemical stimulus involved in sensory perception of sour taste
IAO_0000115: The series of events required for a sour taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of sour taste, detection of chemical stimulus
has exact synonym: perception of sour taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of chemical stimulus during perception of sour taste
has exact synonym: sensory detection of sour taste
has exact synonym: sensory transduction of chemical stimulus during perception of sour taste
has exact synonym: sensory transduction of sour taste
has exact synonym: sour taste detection
has OBO namespace: biological_process
id: GO:0001581
type: Class
subclass of: GO_0050912
subclass of: Restriction
  on property: part_of
  some values from: GO_0050915

detection of chemical stimulus involved in sensory perception of sweet taste
IAO_0000115: The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of sweet taste, detection of chemical stimulus
has exact synonym: perception of sweet taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of chemical stimulus during perception of sweet taste
has exact synonym: sensory detection of sweet taste
has exact synonym: sensory transduction of chemical stimulus during perception of sweet taste
has exact synonym: sensory transduction of sweet taste
has exact synonym: sweet taste detection
has OBO namespace: biological_process
id: GO:0001582
type: Class
subclass of: GO_0050912
subclass of: Restriction
  on property: part_of
  some values from: GO_0050916

detection of chemical stimulus involved in sensory perception of salty taste
IAO_0000115: The series of events required for a salty taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of salty taste, detection of chemical stimulus
has exact synonym: perception of salty taste, sensory transduction of chemical stimulus
has exact synonym: salty taste detection
has exact synonym: sensory detection of chemical stimulus during perception of salty taste
has exact synonym: sensory detection of salty taste
has exact synonym: sensory transduction of chemical stimulus during perception of salty taste
has exact synonym: sensory transduction of salty taste
has OBO namespace: biological_process
id: GO:0001583
type: Class
subclass of: GO_0050912
subclass of: Restriction
  on property: part_of
  some values from: GO_0050914

rhodopsin-like receptor activity
IAO_0000115: OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor.
has alternative id: GO:0001620
has exact synonym: Class A G protein coupled receptor
has exact synonym: Class A G-protein coupled receptor
has exact synonym: Class A GPCR
has exact synonym: class A orphan receptor activity
has OBO namespace: molecular_function
id: GO:0001584
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
deprecated: true

Gi/o-coupled serotonin receptor activity
IAO_0000115: Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
has exact synonym: 5-HT1 receptor activity
has exact synonym: serotonin receptor activity, coupled via Gi/o
has OBO namespace: molecular_function
id: GO:0001586
type: Class
subclass of: GO_0004993

Gq/11-coupled serotonin receptor activity
IAO_0000115: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
has broad synonym: 5-HT2 receptor activity
has exact synonym: serotonin receptor activity, coupled via Gq/11
has OBO namespace: molecular_function
id: GO:0001587
type: Class
subclass of: GO_0004993

dopamine receptor activity, coupled via Gs
IAO_0000115: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
has alternative id: GO:0001589
has alternative id: GO:0001590
has narrow synonym: dopamine D1 receptor activity
has narrow synonym: dopamine D5 receptor activity
has OBO namespace: molecular_function
id: GO:0001588
type: Class
subclass of: GO_0004952

dopamine receptor activity, coupled via Gi/Go
IAO_0000115: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
has alternative id: GO:0001592
has alternative id: GO:0001593
has alternative id: GO:0001670
has narrow synonym: dopamine D2 receptor activity
has narrow synonym: dopamine D3 receptor activity
has narrow synonym: dopamine D4 receptor activity
has OBO namespace: molecular_function
id: GO:0001591
type: Class
subclass of: GO_0004952

trace-amine receptor activity
IAO_0000115: Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
has OBO namespace: molecular_function
id: GO:0001594
type: Class
subclass of: GO_0008227

angiotensin receptor activity
IAO_0000115: Combining with angiotensin to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001595
type: Class
subclass of: GO_0008528

angiotensin type I receptor activity
IAO_0000115: An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.
has OBO namespace: molecular_function
id: GO:0001596
type: Class
subclass of: angiotensin receptor activity

apelin-like receptor
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0031704
has exact synonym: APJ-like receptor
has OBO namespace: molecular_function
id: GO:0001597
type: Class
comment: This term was made obsolete because the function it represents does not exist.
deprecated: true

chemokine receptor-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001598
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

peptide YY receptor activity
IAO_0000115: Combining with gut peptide YY to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001601
type: Class
subclass of: GO_0004983

pancreatic polypeptide receptor activity
IAO_0000115: Combining with pancreatic polypeptide PP to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001602
type: Class
subclass of: GO_0004983

vasopressin-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001603
type: Class
deprecated: true

urotensin II receptor activity
IAO_0000115: Combining with urotensin II to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001604
type: Class
subclass of: GO_0008528

adrenomedullin receptor activity
IAO_0000115: Combining with adrenomedullin to initiate a change in cell activity.
has narrow synonym: G10D receptor
has OBO namespace: molecular_function
id: GO:0001605
type: Class
subclass of: GO_0008528

GPR37/endothelin B-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001606
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

neuromedin U receptor activity
IAO_0000115: Combining with neuromedin U to initiate a change in cell activity.
has exact synonym: NMUR activity
has OBO namespace: molecular_function
id: GO:0001607
type: Class
subclass of: GO_0008188

G-protein coupled nucleotide receptor activity
IAO_0000115: Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein coupled nucleotide receptor activity
has exact synonym: G-protein-coupled nucleotide receptor activity
has exact synonym: nucleotide receptor activity, G protein coupled
has exact synonym: nucleotide receptor activity, G-protein coupled
has OBO namespace: molecular_function
id: GO:0001608
type: Class
subclass of: GO_0004930

G-protein coupled adenosine receptor activity
IAO_0000115: Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has alternative id: GO:0001610
has alternative id: GO:0001611
has alternative id: GO:0001612
has alternative id: GO:0001613
has alternative id: GO:0008501
has broad synonym: adenosine nucleotide receptor
has db xref: Reactome:REACT_105855
has db xref: Reactome:REACT_110350
has db xref: Reactome:REACT_11079
has db xref: Reactome:REACT_29695
has db xref: Reactome:REACT_36513
has db xref: Reactome:REACT_79823
has db xref: Reactome:REACT_89799
has db xref: Reactome:REACT_97530
has db xref: Reactome:REACT_9980
has db xref: Reactome:REACT_99869
has exact synonym: G protein coupled adenosine receptor activity
has exact synonym: G-protein-coupled adenosine receptor activity
has exact synonym: P1 receptor
has exact synonym: adenosine receptor activity, G protein coupled
has exact synonym: adenosine receptor activity, G-protein coupled
has narrow synonym: A1 adenosine receptor activity, G protein coupled
has narrow synonym: A1 adenosine receptor activity, G-protein coupled
has narrow synonym: A2A adenosine receptor activity, G protein coupled
has narrow synonym: A2A adenosine receptor activity, G-protein coupled
has narrow synonym: A2B adenosine receptor activity, G protein coupled
has narrow synonym: A2B adenosine receptor activity, G-protein coupled
has narrow synonym: A3 adenosine receptor activity, G protein coupled
has narrow synonym: A3 adenosine receptor activity, G-protein coupled
has narrow synonym: G protein coupled A1 adenosine receptor activity
has narrow synonym: G protein coupled A2A adenosine receptor activity
has narrow synonym: G protein coupled A2B adenosine receptor activity
has narrow synonym: G protein coupled A3 adenosine receptor activity
has narrow synonym: G-protein-coupled A1 adenosine receptor activity
has narrow synonym: G-protein-coupled A2A adenosine receptor activity
has narrow synonym: G-protein-coupled A2B adenosine receptor activity
has narrow synonym: G-protein-coupled A3 adenosine receptor activity
has OBO namespace: molecular_function
id: GO:0001609
type: Class
subclass of: GO_0004930
subclass of: GO_0035586

purinergic nucleotide receptor activity
IAO_0000115: Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
has related synonym: P2 receptor
id: GO:0001614
type: Class
subclass of: GO_0016502
subclass of: GO_0035586

thyrotropin releasing hormone and secretagogue-like receptors activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001615
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

growth hormone secretagogue receptor activity
IAO_0000115: Combining with ghrelin to initiate a change in cell activity.
has exact synonym: ghrelin receptor activity
has OBO namespace: molecular_function
id: GO:0001616
type: Class
subclass of: GO_0004930

growth hormone secretagogue-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001617
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

viral receptor activity
IAO_0000115: Combining with a virus component and mediating entry of the virus into the cell.
has OBO namespace: molecular_function
id: GO:0001618
type: Class
subclass of: GO_0004872

lysosphingolipid and lysophosphatidic acid receptor activity
IAO_0000115: Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity.
consider: GO:0038036
consider: GO:0070915
has OBO namespace: molecular_function
id: GO:0001619
type: Class
deprecated: true

ADP receptor activity
IAO_0000115: Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has narrow synonym: K101 receptor
has narrow synonym: platelet ADP receptor activity
has OBO namespace: molecular_function
id: GO:0001621
type: Class
subclass of: GO_0045028

nociceptin receptor activity
IAO_0000115: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.
has exact synonym: OFQ receptor activity
has exact synonym: ORPH receptor
has exact synonym: nociceptin/orphanin-FQ receptor activity
has exact synonym: orphanin-FQ receptor activity
has OBO namespace: molecular_function
has related synonym: X-opioid receptor activity
id: GO:0001626
type: Class
subclass of: GO_0004985

leucine-rich G-protein receptor-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has exact synonym: LGR-like receptor
has exact synonym: leucine-rich G protein receptor-like receptor activity
has OBO namespace: molecular_function
id: GO:0001627
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

gastropyloric receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has exact synonym: GPR receptor
has OBO namespace: molecular_function
id: GO:0001628
type: Class
comment: This term was made obsolete because the gastropyloric receptor is a type of neuron.
deprecated: true

G-protein receptor 45-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has exact synonym: G protein receptor 45-like receptor activity
has exact synonym: GPR45-like receptor
has OBO namespace: molecular_function
id: GO:0001629
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

GP40-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001630
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

cysteinyl leukotriene receptor activity
IAO_0000115: Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.
has exact synonym: CysLT receptor
has OBO namespace: molecular_function
id: GO:0001631
type: Class
subclass of: GO_0004974

leukotriene B4 receptor activity
IAO_0000115: Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.
has narrow synonym: BLT receptor
has OBO namespace: molecular_function
id: GO:0001632
type: Class
subclass of: GO_0004974

secretin-like receptor activity
IAO_0000115: OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor.
has alternative id: GO:0001638
has exact synonym: class B G protein coupled receptor
has exact synonym: class B G-protein coupled receptor
has exact synonym: class B GPCR
has exact synonym: class B orphan receptor activity
has OBO namespace: molecular_function
id: GO:0001633
type: Class
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
deprecated: true

pituitary adenylate cyclase-activating polypeptide receptor activity
IAO_0000115: A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide.
has alternative id: GO:0016522
has db xref: Reactome:REACT_10128
has db xref: Reactome:REACT_101685
has db xref: Reactome:REACT_109490
has db xref: Reactome:REACT_11114
has db xref: Reactome:REACT_34105
has db xref: Reactome:REACT_86120
has db xref: Reactome:REACT_87714
has db xref: Reactome:REACT_91558
has db xref: Reactome:REACT_92997
has db xref: Reactome:REACT_96326
has exact synonym: PACAP receptor
has exact synonym: pituitary adenylate cyclase activating polypeptide receptor
has exact synonym: pituitary adenylate cyclase activating protein receptor activity
has exact synonym: pituitary adenylyl cyclase activating protein receptor activity
has OBO namespace: molecular_function
has related synonym: pituitary adenylate cyclase-activating peptide receptor activity
has related synonym: pituitary adenylate cyclase-activating polypeptide receptor activity
id: GO:0001634
type: Class
subclass of: GO_0004930

calcitonin gene-related polypeptide receptor activity
IAO_0000115: Combining with a calcitonin gene-related polypeptide to initiate a change in cell activity.
has db xref: Wikipedia:CALCRL
has exact synonym: CGRP receptor
has OBO namespace: molecular_function
id: GO:0001635
type: Class
subclass of: GO_0004930

corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0001636
type: Class
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
deprecated: true

G-protein coupled chemoattractant receptor activity
IAO_0000115: Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein chemoattractant receptor activity
has exact synonym: G-protein chemoattractant receptor activity
has OBO namespace: molecular_function
id: GO:0001637
type: Class
subclass of: GO_0008528

PLC activating G-protein coupled glutamate receptor activity
IAO_0000115: A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.
has exact synonym: PLC activating metabotropic glutamate receptor activity
has exact synonym: phospholipase C activating metabotropic glutamate receptor activity
has OBO namespace: molecular_function
has related synonym: Group I metabotropic glutamate receptor
has related synonym: group I metabotropic glutamate receptor activity
id: GO:0001639
type: Class
subclass of: GO_0008066

adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
IAO_0000115: Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
has exact synonym: adenylyl cyclase inhibiting metabotropic glutamate receptor activity
has OBO namespace: molecular_function
has related synonym: adenylate cyclase inhibiting metabotropic glutamate receptor activity
id: GO:0001640
type: Class
subclass of: GO_0004930
subclass of: GO_0008066

group II metabotropic glutamate receptor activity
IAO_0000115: A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.
has OBO namespace: molecular_function
id: GO:0001641
type: Class
subclass of: adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

group III metabotropic glutamate receptor activity
IAO_0000115: A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.
has OBO namespace: molecular_function
id: GO:0001642
type: Class
subclass of: adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

cAMP receptor activity
IAO_0000115: Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has alternative id: GO:0001644
has broad synonym: class E G protein coupled receptor
has broad synonym: class E G-protein coupled receptor
has broad synonym: class E GPCR
has exact synonym: 3',5' cAMP receptor activity
has exact synonym: 3',5'-cAMP receptor activity
has exact synonym: adenosine 3',5'-cyclophosphate receptor activity
has exact synonym: cyclic AMP receptor activity
has OBO namespace: molecular_function
id: GO:0001646
type: Class
subclass of: purinergic nucleotide receptor activity

G-protein coupled cytokinin receptor activity
IAO_0000115: Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein coupled cytokinin receptor activity
has exact synonym: G-protein-coupled cytokinin receptor activity
has exact synonym: cytokinin receptor activity, G-protein coupled
has OBO namespace: molecular_function
id: GO:0001647
type: Class
subclass of: GO_0004930
subclass of: GO_0009884

proteinase activated receptor activity
IAO_0000115: A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
has OBO namespace: molecular_function
id: GO:0001648
type: Class
subclass of: GO_0008528

osteoblast differentiation
IAO_0000115: The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
has exact synonym: osteoblast cell differentiation
has OBO namespace: biological_process
id: GO:0001649
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: ossification

fibrillar center
IAO_0000115: A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
has exact synonym: fibrillar centre
has OBO namespace: cellular_component
id: GO:0001650
type: Class
subclass of: GO_0044452

dense fibrillar component
IAO_0000115: A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
has OBO namespace: cellular_component
id: GO:0001651
type: Class
subclass of: GO_0044452

granular component
IAO_0000115: A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
has OBO namespace: cellular_component
id: GO:0001652
type: Class
subclass of: GO_0044452

peptide receptor activity
IAO_0000115: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
has narrow synonym: endogenous peptide receptor activity
has narrow synonym: exogenous peptide receptor activity
has OBO namespace: molecular_function
id: GO:0001653
type: Class
subclass of: GO_0038023

eye development
IAO_0000115: The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
has alternative id: GO:0042460
has db xref: Wikipedia:Eye_development
has OBO namespace: biological_process
id: GO:0001654
type: Class
subclass of: GO_0007423

urogenital system development
IAO_0000115: The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0001655
type: Class
subclass of: GO_0048731

metanephros development
IAO_0000115: The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
has OBO namespace: biological_process
id: GO:0001656
type: Class
subclass of: kidney development

ureteric bud development
IAO_0000115: The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0001657
type: Class
subclass of: GO_0035295
subclass of: Restriction
  on property: part_of
  some values from: GO_0072001

branching involved in ureteric bud morphogenesis
IAO_0000115: The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
has exact synonym: ureteric bud branching
has OBO namespace: biological_process
id: GO:0001658
type: Class
subclass of: GO_0048754
subclass of: GO_0061138
subclass of: Restriction
  on property: part_of
  some values from: GO_0060675

temperature homeostasis
IAO_0000115: A homeostatic process in which an organism modulates its internal body temperature.
has db xref: Wikipedia:Thermoregulation
has exact synonym: thermoregulation
has OBO namespace: biological_process
id: GO:0001659
type: Class
subclass of: GO_0048871

fever generation
IAO_0000115: The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
has broad synonym: pyrexia
has db xref: Wikipedia:Fever
has OBO namespace: biological_process
id: GO:0001660
type: Class
subclass of: GO_0006953
subclass of: GO_0031649

conditioned taste aversion
IAO_0000115: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
has db xref: Wikipedia:Conditioned_taste_aversion
has db xref: Wikipedia:Taste_aversion
has OBO namespace: biological_process
id: GO:0001661
type: Class
subclass of: GO_0007631
subclass of: GO_0008306

behavioral fear response
IAO_0000115: An acute behavioral change resulting from a perceived external threat.
has exact synonym: behavioural fear response
has OBO namespace: biological_process
id: GO:0001662
type: Class
subclass of: behavioral defense response
subclass of: GO_0042596
subclass of: GO_0044708

G-protein coupled receptor binding
IAO_0000115: Interacting selectively and non-covalently with a G-protein coupled receptor.
has db xref: Reactome:REACT_21309
has exact synonym: G protein coupled receptor binding
has exact synonym: G-protein-coupled receptor binding
has narrow synonym: G protein coupled receptor ligand
has narrow synonym: G-protein-coupled receptor ligand
has OBO namespace: molecular_function
id: GO:0001664
type: Class
subclass of: GO_0005102

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.
has db xref: EC:2.4.99.3
has db xref: MetaCyc:2.4.99.3-RXN
has exact synonym: CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity
has exact synonym: GalNAc alpha-2,6-sialyltransferase I activity
has OBO namespace: molecular_function
id: GO:0001665
type: Class
subclass of: GO_0008373

response to hypoxia
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
has exact synonym: response to hypoxic stress
has exact synonym: response to lowered oxygen tension
has OBO namespace: biological_process
id: GO:0001666
type: Class
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
subclass of: GO_0006950
subclass of: GO_0036293

ameboidal cell migration
IAO_0000115: Cell migration that is accomplished by extension and retraction of a pseudopodium.
has exact synonym: ameboid cell migration
has exact synonym: amoeboid cell migration
has exact synonym: amoeboidal cell migration
has OBO namespace: biological_process
id: GO:0001667
type: Class
subclass of: GO_0016477

acrosomal vesicle
IAO_0000115: A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
has db xref: Wikipedia:Acrosome
has exact synonym: acrosomal granule
has OBO namespace: cellular_component
has related synonym: acrosome
id: GO:0001669
type: Class
subclass of: GO_0030141

ATPase activator activity
IAO_0000115: Functions to increase the rate of ATP hydrolysis.
has exact synonym: ATPase stimulator activity
has OBO namespace: molecular_function
id: GO:0001671
type: Class
subclass of: GO_0008047
subclass of: GO_0060590

regulation of chromatin assembly or disassembly
IAO_0000115: Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.
has exact synonym: regulation of chromatin assembly/disassembly
has OBO namespace: biological_process
id: GO:0001672
type: Class
subclass of: GO_0033044
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006333

male germ cell nucleus
IAO_0000115: The nucleus of a male germ cell, a reproductive cell in males.
has alternative id: GO:0043081
has exact synonym: male germ-cell nucleus
has OBO namespace: cellular_component
id: GO:0001673
type: Class
subclass of: GO_0043073

female germ cell nucleus
IAO_0000115: The nucleus of the female germ cell, a reproductive cell in females.
has alternative id: GO:0043080
has exact synonym: female germ-cell nucleus
has OBO namespace: cellular_component
id: GO:0001674
type: Class
subclass of: GO_0043073

acrosome assembly
IAO_0000115: The formation of the acrosome from the spermatid Golgi.
has exact synonym: acrosome formation
has OBO namespace: biological_process
id: GO:0001675
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0010927
subclass of: GO_0022412
subclass of: Restriction
  on property: part_of
  some values from: GO_0007286

long-chain fatty acid metabolic process
IAO_0000115: The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has exact synonym: long-chain fatty acid metabolism
has OBO namespace: biological_process
id: GO:0001676
in subset: gosubset prok
type: Class
subclass of: GO_0006631

formation of translation initiation ternary complex
IAO_0000115: Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
has exact synonym: translation initiation ternary complex assembly
has OBO namespace: biological_process
id: GO:0001677
in subset: gosubset prok
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0006413

cellular glucose homeostasis
IAO_0000115: A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
has exact synonym: cell glucose homeostasis
has OBO namespace: biological_process
id: GO:0001678
in subset: gosubset prok
type: Class
subclass of: GO_0042593
subclass of: GO_0055082

tRNA 3'-terminal CCA addition
IAO_0000115: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.
has broad synonym: ATP(CTP)-tRNA nucleotidyltransferase activity
has broad synonym: ATP(CTP):tRNA nucleotidyltransferase activity
has broad synonym: CCA tRNA nucleotidyltransferase activity
has broad synonym: CTP(ATP):tRNA nucleotidyltransferase activity
has broad synonym: tRNA adenylyl(cytidylyl)transferase activity
has broad synonym: tRNA-nucleotidyltransferase activity
has broad synonym: transfer ribonucleate nucleotidyltransferase activity
has broad synonym: transfer ribonucleic acid nucleotidyl transferase activity
has broad synonym: transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity
has broad synonym: transfer-RNA nucleotidyltransferase activity
has db xref: EC:2.7.7.72
has db xref: KEGG:R09382
has db xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN
has exact synonym: CCA-adding enzyme activity
has exact synonym: CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity
has exact synonym: ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity
has narrow synonym: CTP:tRNA cytidylyltransferase activity
has narrow synonym: ribonucleic cytidylyltransferase activity
has narrow synonym: tRNA cytidylyltransferase activity
has narrow synonym: transfer RNA adenylyltransferase activity
has narrow synonym: transfer ribonucleate adenyltransferase activity
has narrow synonym: transfer ribonucleate adenylyltransferase activity
has narrow synonym: transfer ribonucleate cytidylyltransferase activity
has OBO namespace: biological_process
has related synonym: -C-C-A pyrophosphorylase activity
has related synonym: tRNA CCA-diphosphorylase activity
has related synonym: transfer ribonucleic adenylyl (cytidylyl) transferase activity
id: GO:0001680
in subset: gosubset prok
type: Class
subclass of: GO_0042780

sialate O-acetylesterase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.
has db xref: EC:3.1.1.53
has db xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN
has exact synonym: N-acetylneuraminate acetyltransferase activity
has exact synonym: N-acyl-O-acetylneuraminate O-acetylhydrolase activity
has exact synonym: sialate 9(4)-O-acetylesterase activity
has OBO namespace: molecular_function
id: GO:0001681
in subset: gosubset prok
type: Class
subclass of: GO_0008126

tRNA 5'-leader removal
IAO_0000115: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
has exact synonym: tRNA 5' leader removal
has OBO namespace: biological_process
id: GO:0001682
in subset: gosubset prok
type: Class
subclass of: GO_0008033

axonemal dynein heavy chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005858
has OBO namespace: cellular_component
id: GO:0001683
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

axonemal dynein intermediate chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005858
has OBO namespace: cellular_component
id: GO:0001684
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

axonemal dynein intermediate light chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005858
has OBO namespace: cellular_component
id: GO:0001685
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

axonemal dynein light chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005858
has OBO namespace: cellular_component
id: GO:0001686
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

cytoplasmic dynein heavy chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005868
has OBO namespace: cellular_component
id: GO:0001687
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

cytoplasmic dynein intermediate chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005868
has OBO namespace: cellular_component
id: GO:0001688
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

cytoplasmic dynein intermediate light chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005868
has OBO namespace: cellular_component
id: GO:0001689
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

cytoplasmic dynein light chain
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0005868
has OBO namespace: cellular_component
id: GO:0001690
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

pseudophosphatase activity
IAO_0000115: Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.
has OBO namespace: molecular_function
id: GO:0001691
type: Class
subclass of: GO_0019212

histamine metabolic process
IAO_0000115: The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine metabolism
has OBO namespace: biological_process
id: GO:0001692
type: Class
subclass of: GO_0006576
subclass of: GO_0052803

histamine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has alternative id: GO:0001693
has db xref: Reactome:REACT_115661
has exact synonym: histamine anabolism
has exact synonym: histamine biosynthesis
has exact synonym: histamine formation
has exact synonym: histamine synthesis
has OBO namespace: biological_process
id: GO:0001694
type: Class
subclass of: histamine metabolic process
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_0042401
subclass of: GO_1901362

histamine catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine breakdown
has exact synonym: histamine catabolism
has exact synonym: histamine degradation
has OBO namespace: biological_process
id: GO:0001695
type: Class
subclass of: histamine metabolic process
subclass of: GO_0042135
subclass of: GO_0042402
subclass of: GO_0052805

gastric acid secretion
IAO_0000115: The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
has narrow synonym: hydrochloric acid secretion
has OBO namespace: biological_process
id: GO:0001696
type: Class
subclass of: GO_0022600
subclass of: GO_0046717

histamine-induced gastric acid secretion
IAO_0000115: The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.
has OBO namespace: biological_process
id: GO:0001697
type: Class
subclass of: gastric acid secretion

gastrin-induced gastric acid secretion
IAO_0000115: The regulated release of gastric acid induced by the interaction of gastrin with its receptor.
has OBO namespace: biological_process
id: GO:0001698
type: Class
subclass of: gastric acid secretion

acetylcholine-induced gastric acid secretion
IAO_0000115: The regulated release of gastric acid by parietal cells in response to acetylcholine.
has OBO namespace: biological_process
id: GO:0001699
type: Class
subclass of: gastric acid secretion

embryonic development via the syncytial blastoderm
IAO_0000115: The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.
has OBO namespace: biological_process
id: GO:0001700
type: Class
subclass of: GO_0009792

in utero embryonic development
IAO_0000115: The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
has OBO namespace: biological_process
id: GO:0001701
type: Class
subclass of: GO_0043009

gastrulation with mouth forming second
IAO_0000115: A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
has alternative id: GO:0010003
has alternative id: GO:0048276
has exact synonym: deuterostomic gastrulation
has OBO namespace: biological_process
id: GO:0001702
type: Class
subclass of: GO_0007369

gastrulation with mouth forming first
IAO_0000115: A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.
has narrow synonym: protostomic gastrulation
has OBO namespace: biological_process
id: GO:0001703
type: Class
subclass of: GO_0007369

formation of primary germ layer
IAO_0000115: The formation of the ectoderm, mesoderm and endoderm during gastrulation.
has OBO namespace: biological_process
id: GO:0001704
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0007369

ectoderm formation
IAO_0000115: The formation of ectoderm during gastrulation.
has OBO namespace: biological_process
id: GO:0001705
type: Class
subclass of: formation of primary germ layer
subclass of: Restriction
  on property: part_of
  some values from: GO_0007398

endoderm formation
IAO_0000115: The formation of the endoderm during gastrulation.
has narrow synonym: endoblast formation
has OBO namespace: biological_process
id: GO:0001706
type: Class
subclass of: formation of primary germ layer
subclass of: Restriction
  on property: part_of
  some values from: GO_0007492

mesoderm formation
IAO_0000115: The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
has OBO namespace: biological_process
id: GO:0001707
type: Class
subclass of: formation of primary germ layer
subclass of: Restriction
  on property: part_of
  some values from: GO_0048332

cell fate specification
IAO_0000115: The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
has OBO namespace: biological_process
id: GO:0001708
type: Class
subclass of: GO_0048869
subclass of: Restriction
  on property: part_of
  some values from: GO_0045165

cell fate determination
IAO_0000115: A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
has db xref: Wikipedia:Cell_fate_determination
has OBO namespace: biological_process
id: GO:0001709
type: Class
subclass of: GO_0048869
subclass of: Restriction
  on property: part_of
  some values from: GO_0045165

mesodermal cell fate commitment
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the mesoderm.
has exact synonym: mesoderm cell fate commitment
has OBO namespace: biological_process
id: GO:0001710
type: Class
subclass of: GO_0060795
subclass of: Restriction
  on property: part_of
  some values from: GO_0048333

endodermal cell fate commitment
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the endoderm.
has exact synonym: endoderm cell fate commitment
has OBO namespace: biological_process
id: GO:0001711
type: Class
subclass of: GO_0060795
subclass of: Restriction
  on property: part_of
  some values from: GO_0035987

ectodermal cell fate commitment
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the ectoderm.
has exact synonym: ectoderm cell fate commitment
has OBO namespace: biological_process
id: GO:0001712
type: Class
subclass of: GO_0060795
subclass of: Restriction
  on property: part_of
  some values from: GO_0010668
subclass of: Restriction
  on property: part_of
  some values from: ectoderm formation

ectodermal cell fate determination
IAO_0000115: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
has exact synonym: ectoderm cell fate determination
has OBO namespace: biological_process
id: GO:0001713
type: Class
subclass of: cell fate determination
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: ectodermal cell fate commitment

endodermal cell fate specification
IAO_0000115: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
has exact synonym: endoderm cell fate specification
has OBO namespace: biological_process
id: GO:0001714
type: Class
subclass of: cell fate specification
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: endodermal cell fate commitment

ectodermal cell fate specification
IAO_0000115: The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
has exact synonym: ectoderm cell fate specification
has OBO namespace: biological_process
id: GO:0001715
type: Class
subclass of: cell fate specification
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: ectodermal cell fate commitment

L-amino-acid oxidase activity
IAO_0000115: Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
has db xref: EC:1.4.3.2
has db xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN
has db xref: RHEA:13784
has exact synonym: L-amino-acid:oxygen oxidoreductase (deaminating)
has exact synonym: ophio-amino-acid oxidase activity
has OBO namespace: molecular_function
id: GO:0001716
in subset: gosubset prok
type: Class
subclass of: GO_0016641

conversion of seryl-tRNAsec to selenocys-tRNAsec
IAO_0000115: The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine.
has OBO namespace: biological_process
id: GO:0001717
in subset: gosubset prok
type: Class
subclass of: GO_0019988

conversion of lysyl-tRNA to pyrrolysyl-tRNA
IAO_0000115: The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate).
has OBO namespace: biological_process
id: GO:0001720
in subset: gosubset prok
type: Class
subclass of: GO_0019988

intermediate filament associated protein
IAO_0000115: OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks.
IAO_0100001: GO:0005882
has exact synonym: IFAP
has OBO namespace: cellular_component
id: GO:0001721
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

type I intermediate filament associated protein
IAO_0000115: OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates.
IAO_0100001: GO:0005882
has OBO namespace: cellular_component
id: GO:0001722
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

type II intermediate filament associated protein
IAO_0000115: OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks.
IAO_0100001: GO:0005882
has OBO namespace: cellular_component
id: GO:0001723
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

type III intermediate filament associated protein
IAO_0000115: OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane.
IAO_0100001: GO:0045098
has OBO namespace: cellular_component
id: GO:0001724
type: Class
comment: This term was made obsolete because it represents a single gene product and not a complex.
deprecated: true

stress fiber
IAO_0000115: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
has exact synonym: stress fibre
has OBO namespace: cellular_component
has related synonym: actin cable
id: GO:0001725
type: Class
subclass of: GO_0032432
subclass of: GO_0042641

ruffle
IAO_0000115: Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
has OBO namespace: cellular_component
has related synonym: membrane ruffle
id: GO:0001726
type: Class
subclass of: GO_0042995
subclass of: Restriction
  on property: part_of
  some values from: GO_0031252

lipid kinase activity
IAO_0000115: Catalysis of the phosphorylation of a simple or complex lipid.
has OBO namespace: molecular_function
id: GO:0001727
in subset: gosubset prok
type: Class
subclass of: GO_0016301

ceramide kinase activity
IAO_0000115: Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.
has db xref: EC:2.7.1.138
has db xref: MetaCyc:CERAMIDE-KINASE-RXN
has db xref: RHEA:17932
has db xref: Reactome:REACT_116045
has exact synonym: ATP:ceramide 1-phosphotransferase activity
has exact synonym: acylsphingosine kinase activity
has OBO namespace: molecular_function
id: GO:0001729
type: Class
subclass of: lipid kinase activity

2'-5'-oligoadenylate synthetase activity
IAO_0000115: Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
has db xref: MetaCyc:RXN-10798
has exact synonym: (2-5')oligo(A) synthetase activity
has exact synonym: 2'-5' oligoadenylate synthetase activity
has exact synonym: 2-5A synthetase activity
has exact synonym: oligo-2',5'-adenylate synthetase activity
has OBO namespace: molecular_function
id: GO:0001730
type: Class
subclass of: GO_0070566

formation of translation preinitiation complex
IAO_0000115: The joining of the small ribosomal subunit, ternary complex, and mRNA.
has exact synonym: formation of translation pre-initiation complex
has exact synonym: translation preinitiation complex assembly
has OBO namespace: biological_process
id: GO:0001731
in subset: gosubset prok
type: Class
comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children.
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0006413

formation of translation initiation complex
IAO_0000115: Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
has exact synonym: translation initiation complex assembly
has OBO namespace: biological_process
id: GO:0001732
in subset: gosubset prok
type: Class
subclass of: GO_0022618
subclass of: Restriction
  on property: part_of
  some values from: GO_0006413

galactosylceramide sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
has db xref: EC:2.8.2.11
has db xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN
has db xref: RHEA:20616
has db xref: Reactome:REACT_115577
has exact synonym: 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity
has exact synonym: 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity
has exact synonym: GSase
has exact synonym: cerebroside sulfotransferase activity
has exact synonym: galactocerebroside sulfotransferase activity
has exact synonym: galactolipid sulfotransferase activity
has exact synonym: galactosylceramide sulphotransferase activity
has exact synonym: glycolipid sulfotransferase activity
has exact synonym: glycosphingolipid sulfotransferase activity
has OBO namespace: molecular_function
id: GO:0001733
type: Class
subclass of: GO_0050694

mRNA (N6-adenosine)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.
has db xref: Reactome:REACT_101890
has db xref: Reactome:REACT_1720
has db xref: Reactome:REACT_28538
has db xref: Reactome:REACT_28726
has db xref: Reactome:REACT_30916
has db xref: Reactome:REACT_32129
has db xref: Reactome:REACT_85371
has db xref: Reactome:REACT_88666
has db xref: Reactome:REACT_90117
has db xref: Reactome:REACT_91818
has db xref: Reactome:REACT_92618
has db xref: Reactome:REACT_96892
has OBO namespace: molecular_function
id: GO:0001734
type: Class
subclass of: GO_0008174

prenylcysteine oxidase activity
IAO_0000115: Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.
has db xref: EC:1.8.3.5
has db xref: MetaCyc:1.8.3.5-RXN
has exact synonym: S-prenyl-L-cysteine:oxygen oxidoreductase activity
has exact synonym: prenylcysteine lyase activity
has OBO namespace: molecular_function
id: GO:0001735
type: Class
subclass of: GO_0016670

establishment of planar polarity
IAO_0000115: Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
has narrow synonym: establishment of planar cell polarity
has OBO namespace: biological_process
id: GO:0001736
type: Class
subclass of: GO_0007164
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: morphogenesis of a polarized epithelium

establishment of imaginal disc-derived wing hair orientation
IAO_0000115: Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
has exact synonym: establishment of wing hair orientation
has OBO namespace: biological_process
id: GO:0001737
type: Class
subclass of: establishment of planar polarity
subclass of: GO_0009886
subclass of: Restriction
  on property: part_of
  some values from: GO_0035317

morphogenesis of a polarized epithelium
IAO_0000115: The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
has exact synonym: epithelial polarization
has OBO namespace: biological_process
id: GO:0001738
type: Class
subclass of: morphogenesis of an epithelium

sex chromatin
IAO_0000115: A condensed mass of compacted chromatin that represents an inactivated X chromosome.
has OBO namespace: cellular_component
id: GO:0001739
type: Class
subclass of: GO_0005720
subclass of: Restriction
  on property: part_of
  some values from: sex chromosome

Barr body
IAO_0000115: A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
has db xref: Wikipedia:Barr_body
has OBO namespace: cellular_component
id: GO:0001740
type: Class
subclass of: nuclear chromosome
subclass of: X chromosome

XY body
IAO_0000115: A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
has OBO namespace: cellular_component
id: GO:0001741
type: Class
subclass of: sex chromosome

oenocyte differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.
has exact synonym: oenocyte cell differentiation
has OBO namespace: biological_process
id: GO:0001742
type: Class
subclass of: GO_0030154

optic placode formation
IAO_0000115: The initial developmental process that will lead to the formation of an eye.
has OBO namespace: biological_process
id: GO:0001743
type: Class
subclass of: GO_0060788
subclass of: Restriction
  on property: part_of
  some values from: GO_0048598

optic lobe placode formation
IAO_0000115: Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system.
has alternative id: GO:0007457
has exact synonym: optic lobe and Bolwig's organ precursor formation
has OBO namespace: biological_process
id: GO:0001744
type: Class
subclass of: optic placode formation
subclass of: Restriction
  on property: part_of
  some values from: optic lobe placode development

compound eye morphogenesis
IAO_0000115: The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
has exact synonym: insect-type retina morphogenesis
has OBO namespace: biological_process
id: GO:0001745
type: Class
subclass of: GO_0048592
subclass of: Restriction
  on property: part_of
  some values from: GO_0048749

Bolwig's organ morphogenesis
IAO_0000115: The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.
has OBO namespace: biological_process
id: GO:0001746
type: Class
subclass of: GO_0048592
subclass of: Restriction
  on property: part_of
  some values from: GO_0055034

optic lobe placode development
IAO_0000115: The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster.
has alternative id: GO:0048049
has broad synonym: optic placode development
has exact synonym: optic lobe and Bolwig's organ precursor development
has OBO namespace: biological_process
id: GO:0001748
type: Class
subclass of: GO_0048856

photoreceptor outer segment
IAO_0000115: The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.
has OBO namespace: cellular_component
id: GO:0001750
type: Class
subclass of: GO_0031513

compound eye photoreceptor cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
has OBO namespace: biological_process
id: GO:0001751
type: Class
subclass of: eye photoreceptor cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: compound eye morphogenesis

compound eye photoreceptor fate commitment
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.
has alternative id: GO:0007459
has OBO namespace: biological_process
id: GO:0001752
type: Class
subclass of: GO_0042706
subclass of: Restriction
  on property: part_of
  some values from: compound eye photoreceptor cell differentiation

adult eye photoreceptor development (sensu Drosophila)
IAO_0000115: OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye.
consider: GO:0042051
has OBO namespace: biological_process
id: GO:0001753
type: Class
comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins.
deprecated: true

eye photoreceptor cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
has OBO namespace: biological_process
id: GO:0001754
type: Class
subclass of: GO_0046530
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0048592

neural crest cell migration
IAO_0000115: The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
has OBO namespace: biological_process
id: GO:0001755
type: Class
subclass of: ameboidal cell migration
subclass of: Restriction
  on property: part_of
  some values from: GO_0014032

somitogenesis
IAO_0000115: The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
has db xref: Wikipedia:Somitogenesis
has exact synonym: formation of mesodermal clusters
has OBO namespace: biological_process
id: GO:0001756
type: Class
subclass of: GO_0009952
subclass of: GO_0035282
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0061053
subclass of: Restriction
  on property: part_of
  some values from: GO_0043009

somite specification
IAO_0000115: The process in which individual somites establish identity during embryogenesis.
has OBO namespace: biological_process
id: GO:0001757
type: Class
subclass of: GO_0007379
subclass of: GO_0009880
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: somitogenesis

retinal dehydrogenase activity
IAO_0000115: Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
has db xref: EC:1.2.1.36
has db xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN
has db xref: RHEA:16180
has exact synonym: cytosolic retinal dehydrogenase activity
has exact synonym: retinal:NAD+ oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0001758
type: Class
subclass of: GO_0016620

organ induction
IAO_0000115: The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.
has exact synonym: induction of an organ
has OBO namespace: biological_process
id: GO:0001759
type: Class
subclass of: regulation of organ formation
subclass of: GO_0031128
subclass of: GO_0051094
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0010092

aminocarboxymuconate-semialdehyde decarboxylase activity
IAO_0000115: Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2).
has db xref: EC:4.1.1.45
has db xref: KEGG:R04323
has db xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN
has db xref: RHEA:16560
has exact synonym: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)
has exact synonym: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity
has exact synonym: 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity
has exact synonym: alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity
has exact synonym: alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity
has exact synonym: picolinic acid carboxylase activity
has exact synonym: picolinic acid decarboxylase activity
has OBO namespace: molecular_function
id: GO:0001760
in subset: gosubset prok
type: Class
subclass of: GO_0016831

beta-alanine transmembrane transporter activity
IAO_0000115: Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.
has broad synonym: beta-alanine transporter activity
has OBO namespace: molecular_function
id: GO:0001761
type: Class
subclass of: GO_0015175

beta-alanine transport
IAO_0000115: The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has OBO namespace: biological_process
id: GO:0001762
type: Class
subclass of: GO_0015804

morphogenesis of a branching structure
IAO_0000115: The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
has exact synonym: branching morphogenesis
has OBO namespace: biological_process
id: GO:0001763
type: Class
subclass of: GO_0009653
subclass of: GO_0044707

neuron migration
IAO_0000115: The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
has db xref: Wikipedia:Neural_development#Neuron_migration
has db xref: Wikipedia:Neuron_migration
has exact synonym: neuron chemotaxis
has exact synonym: neuronal migration
has OBO namespace: biological_process
has related synonym: neuron guidance
id: GO:0001764
type: Class
subclass of: GO_0016477
subclass of: Restriction
  on property: part_of
  some values from: GO_0048699

membrane raft assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
has exact synonym: lipid raft assembly
has OBO namespace: biological_process
has related synonym: lipid raft formation
has related synonym: membrane raft formation
id: GO:0001765
type: Class
subclass of: GO_0022607
subclass of: GO_0031579

membrane raft polarization
IAO_0000115: The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes.
has exact synonym: lipid raft polarization
has OBO namespace: biological_process
id: GO:0001766
type: Class
subclass of: GO_0031580

establishment of lymphocyte polarity
IAO_0000115: The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.
has exact synonym: lymphocyte polarization
has OBO namespace: biological_process
id: GO:0001767
type: Class
subclass of: GO_0030010
subclass of: Restriction
  on property: part_of
  some values from: GO_0046649

establishment of T cell polarity
IAO_0000115: The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.
has exact synonym: T cell polarization
has exact synonym: T lymphocyte polarization
has exact synonym: T-cell polarization
has exact synonym: establishment of T lymphocyte polarity
has exact synonym: establishment of T-cell polarity
has exact synonym: establishment of T-lymphocyte polarity
has OBO namespace: biological_process
id: GO:0001768
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: Restriction
  on property: part_of
  some values from: GO_0042110

establishment of B cell polarity
IAO_0000115: The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.
has exact synonym: B cell polarization
has exact synonym: B lymphocyte polarization
has exact synonym: B-cell polarization
has exact synonym: establishment of B lymphocyte polarity
has exact synonym: establishment of B-cell polarity
has exact synonym: establishment of B-lymphocyte polarity
has OBO namespace: biological_process
id: GO:0001769
type: Class
comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
subclass of: establishment of lymphocyte polarity
subclass of: Restriction
  on property: part_of
  some values from: GO_0042113

establishment of natural killer cell polarity
IAO_0000115: The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.
has exact synonym: NK cell polarization
has exact synonym: establishment of NK cell polarity
has exact synonym: natural killer cell polarization
has OBO namespace: biological_process
id: GO:0001770
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: Restriction
  on property: part_of
  some values from: GO_0030101

immunological synapse formation
IAO_0000115: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
has exact synonym: formation of immunological synapse
has OBO namespace: biological_process
id: GO:0001771
type: Class
subclass of: GO_0009988
subclass of: Restriction
  on property: part_of
  some values from: GO_0046649

immunological synapse
IAO_0000115: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
has db xref: Wikipedia:Immunological_synapse
has exact synonym: supramolecular activation cluster
has narrow synonym: c-SMAC
has OBO namespace: cellular_component
id: GO:0001772
type: Class
subclass of: GO_0044459

myeloid dendritic cell activation
IAO_0000115: The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
has OBO namespace: biological_process
id: GO:0001773
type: Class
subclass of: myeloid leukocyte activation

microglial cell activation
IAO_0000115: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
has OBO namespace: biological_process
id: GO:0001774
type: Class
subclass of: GO_0042116

cell activation
IAO_0000115: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
has OBO namespace: biological_process
id: GO:0001775
in subset: goslim pir
type: Class
subclass of: GO_0044763

leukocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has exact synonym: immune cell homeostasis
has exact synonym: leucocyte homeostasis
has OBO namespace: biological_process
id: GO:0001776
type: Class
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
subclass of: immune system process
subclass of: GO_0048872

T cell homeostatic proliferation
IAO_0000115: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
has exact synonym: T lymphocyte homeostatic proliferation
has exact synonym: T-cell homeostatic proliferation
has exact synonym: T-lymphocyte homeostatic proliferation
has exact synonym: resting T cell proliferation
has exact synonym: resting T-cell proliferation
has OBO namespace: biological_process
id: GO:0001777
type: Class
subclass of: GO_0042098
subclass of: Restriction
  on property: part_of
  some values from: GO_0043029

plasma membrane repair
IAO_0000115: The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
has OBO namespace: biological_process
id: GO:0001778
type: Class
subclass of: GO_0007009
subclass of: Restriction
  on property: part_of
  some values from: GO_0042060

natural killer cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
has exact synonym: NK cell differentiation
has OBO namespace: biological_process
has related synonym: natural killer cell development
id: GO:0001779
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0030098
subclass of: GO_0030101

neutrophil homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has OBO namespace: biological_process
id: GO:0001780
type: Class
comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
subclass of: leukocyte homeostasis
subclass of: myeloid cell homeostasis

neutrophil apoptotic process
IAO_0000115: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
has exact synonym: apoptosis of neutrophils
has exact synonym: neutrophil programmed cell death by apoptosis
has exact synonym: programmed cell death of neutrophils by apoptosis
has exact synonym: programmed cell death, neutrophils
has narrow synonym: neutrophil apoptosis
has OBO namespace: biological_process
id: GO:0001781
type: Class
subclass of: GO_0006925
subclass of: GO_0033028
subclass of: Restriction
  on property: part_of
  some values from: neutrophil homeostasis

B cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has exact synonym: B lymphocyte homeostasis
has exact synonym: B-cell homeostasis
has exact synonym: B-lymphocyte homeostasis
has OBO namespace: biological_process
id: GO:0001782
type: Class
comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
subclass of: lymphocyte homeostasis

B cell apoptotic process
IAO_0000115: Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
has exact synonym: B cell programmed cell death by apoptosis
has exact synonym: B lymphocyte apoptosis
has exact synonym: B lymphocyte programmed cell death by apoptosis
has exact synonym: B-cell apoptosis
has exact synonym: B-cell programmed cell death by apoptosis
has exact synonym: B-lymphocyte apoptosis
has exact synonym: B-lymphocyte programmed cell death by apoptosis
has exact synonym: apoptosis of B cells
has exact synonym: apoptosis of B lymphocytes
has exact synonym: apoptosis of B-cells
has exact synonym: apoptosis of B-lymphocytes
has exact synonym: programmed cell death of B cells by apoptosis
has exact synonym: programmed cell death of B lymphocytes by apoptosis
has exact synonym: programmed cell death of B-cells by apoptosis
has exact synonym: programmed cell death of B-lymphocytes by apoptosis
has exact synonym: programmed cell death, B cells
has exact synonym: programmed cell death, B lymphocytes
has exact synonym: programmed cell death, B-cells
has exact synonym: programmed cell death, B-lymphocytes
has narrow synonym: B cell apoptosis
has OBO namespace: biological_process
id: GO:0001783
type: Class
subclass of: GO_0070227

phosphotyrosine binding
IAO_0000115: Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
has OBO namespace: molecular_function
id: GO:0001784
type: Class
subclass of: GO_0045309

prostaglandin J receptor activity
IAO_0000115: Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.
has exact synonym: PGJ(2) receptor activity
has OBO namespace: molecular_function
has related synonym: PGJ receptor activity
id: GO:0001785
type: Class
subclass of: GO_0004955

phosphatidylserine binding
IAO_0000115: Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
has OBO namespace: molecular_function
id: GO:0001786
type: Class
subclass of: GO_0005543
subclass of: GO_0072341

natural killer cell proliferation
IAO_0000115: The expansion of a natural killer cell population by cell division.
has exact synonym: NK cell proliferation
has OBO namespace: biological_process
id: GO:0001787
type: Class
subclass of: GO_0030101
subclass of: GO_0046651

antibody-dependent cellular cytotoxicity
IAO_0000115: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
has db xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity
has db xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity
has exact synonym: ADCC
has exact synonym: antibody dependent cell death
has exact synonym: antibody dependent cell killing
has exact synonym: antibody-dependent cell death
has exact synonym: antibody-dependent cell killing
has exact synonym: type VI hypersensitivity
has OBO namespace: biological_process
id: GO:0001788
type: Class
subclass of: type IIa hypersensitivity
subclass of: leukocyte mediated cytotoxicity

G-protein coupled receptor signaling pathway, coupled to S1P second messenger
IAO_0000115: The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of sphingosine kinase and a subsequent increase in cellular levels of sphingosine-1-phosphate (S1P).
has exact synonym: G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)
has exact synonym: G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)
has exact synonym: G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)
has exact synonym: GPCR signaling pathway via activation of sphingosine kinase activity
has exact synonym: sphingosine kinase-activating G-protein coupled receptor signaling pathway
has exact synonym: sphingosine kinase-activating GPCR signaling pathway
has OBO namespace: biological_process
id: GO:0001789
type: Class
subclass of: GO_0007186

polymeric immunoglobulin binding
IAO_0000115: Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.
has OBO namespace: molecular_function
id: GO:0001790
type: Class
subclass of: GO_0019865

IgM binding
IAO_0000115: Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype.
has OBO namespace: molecular_function
id: GO:0001791
type: Class
subclass of: GO_0019865

polymeric immunoglobulin receptor activity
IAO_0000115: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001792
type: Class
subclass of: GO_0019763

IgM receptor activity
IAO_0000115: Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001793
type: Class
subclass of: GO_0019763

type IIa hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.
has OBO namespace: biological_process
id: GO:0001794
type: Class
comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.
subclass of: type II hypersensitivity

type IIb hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
has exact synonym: type V hypersensitivity
has OBO namespace: biological_process
id: GO:0001795
type: Class
comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity.
subclass of: type II hypersensitivity

regulation of type IIa hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.
has OBO namespace: biological_process
id: GO:0001796
type: Class
subclass of: regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002211
  some values from: type IIa hypersensitivity

negative regulation of type IIa hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type IIa hypersensitivity
has exact synonym: down-regulation of type IIa hypersensitivity
has exact synonym: downregulation of type IIa hypersensitivity
has narrow synonym: inhibition of type IIa hypersensitivity
has OBO namespace: biological_process
id: GO:0001797
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: negative regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002212
  some values from: type IIa hypersensitivity

positive regulation of type IIa hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type IIa hypersensitivity
has exact synonym: up-regulation of type IIa hypersensitivity
has exact synonym: upregulation of type IIa hypersensitivity
has narrow synonym: activation of type IIa hypersensitivity
has narrow synonym: stimulation of type IIa hypersensitivity
has OBO namespace: biological_process
id: GO:0001798
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: positive regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002213
  some values from: type IIa hypersensitivity

regulation of type IIb hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.
has OBO namespace: biological_process
id: GO:0001799
type: Class
subclass of: regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002211
  some values from: type IIb hypersensitivity

negative regulation of type IIb hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type IIb hypersensitivity
has exact synonym: down-regulation of type IIb hypersensitivity
has exact synonym: downregulation of type IIb hypersensitivity
has narrow synonym: inhibition of type IIb hypersensitivity
has OBO namespace: biological_process
id: GO:0001800
type: Class
subclass of: regulation of type IIb hypersensitivity
subclass of: negative regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002212
  some values from: type IIb hypersensitivity

positive regulation of type IIb hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type IIb hypersensitivity
has exact synonym: up-regulation of type IIb hypersensitivity
has exact synonym: upregulation of type IIb hypersensitivity
has narrow synonym: activation of type IIb hypersensitivity
has narrow synonym: stimulation of type IIb hypersensitivity
has OBO namespace: biological_process
id: GO:0001801
type: Class
subclass of: regulation of type IIb hypersensitivity
subclass of: positive regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002213
  some values from: type IIb hypersensitivity

type III hypersensitivity
IAO_0000115: An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue.
has db xref: Wikipedia:Type_III_hypersensitivity
has OBO namespace: biological_process
id: GO:0001802
type: Class
comment: Note that the Arthus reaction is an example of type III hypersensitivity.
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: GO_0016064

regulation of type III hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.
has OBO namespace: biological_process
id: GO:0001803
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: type III hypersensitivity

negative regulation of type III hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type III hypersensitivity
has exact synonym: down-regulation of type III hypersensitivity
has exact synonym: downregulation of type III hypersensitivity
has narrow synonym: inhibition of type III hypersensitivity
has OBO namespace: biological_process
id: GO:0001804
type: Class
subclass of: regulation of type III hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: type III hypersensitivity

positive regulation of type III hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type III hypersensitivity
has exact synonym: up-regulation of type III hypersensitivity
has exact synonym: upregulation of type III hypersensitivity
has narrow synonym: activation of type III hypersensitivity
has narrow synonym: stimulation of type III hypersensitivity
has OBO namespace: biological_process
id: GO:0001805
type: Class
subclass of: regulation of type III hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: type III hypersensitivity

type IV hypersensitivity
IAO_0000115: An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
has alternative id: GO:0016069
has db xref: Wikipedia:Type_IV_hypersensitivity
has exact synonym: delayed hypersensitivity response
has exact synonym: delayed-type hypersensitivity
has OBO namespace: biological_process
id: GO:0001806
type: Class
subclass of: T cell mediated immunity
subclass of: hypersensitivity

regulation of type IV hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.
has OBO namespace: biological_process
id: GO:0001807
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of hypersensitivity
subclass of: Restriction
  on property: RO_0002211
  some values from: type IV hypersensitivity

negative regulation of type IV hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type IV hypersensitivity
has exact synonym: down-regulation of type IV hypersensitivity
has exact synonym: downregulation of type IV hypersensitivity
has narrow synonym: inhibition of type IV hypersensitivity
has OBO namespace: biological_process
id: GO:0001808
type: Class
subclass of: regulation of type IV hypersensitivity
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of hypersensitivity
subclass of: Restriction
  on property: RO_0002212
  some values from: type IV hypersensitivity

positive regulation of type IV hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type IV hypersensitivity
has exact synonym: up-regulation of type IV hypersensitivity
has exact synonym: upregulation of type IV hypersensitivity
has narrow synonym: activation of type IV hypersensitivity
has narrow synonym: stimulation of type IV hypersensitivity
has OBO namespace: biological_process
id: GO:0001809
type: Class
subclass of: regulation of type IV hypersensitivity
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of hypersensitivity
subclass of: Restriction
  on property: RO_0002213
  some values from: type IV hypersensitivity

regulation of type I hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.
has OBO namespace: biological_process
id: GO:0001810
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0016068

negative regulation of type I hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type I hypersensitivity
has exact synonym: down-regulation of type I hypersensitivity
has exact synonym: downregulation of type I hypersensitivity
has narrow synonym: inhibition of type I hypersensitivity
has OBO namespace: biological_process
id: GO:0001811
type: Class
subclass of: regulation of type I hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0016068

positive regulation of type I hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type I hypersensitivity
has exact synonym: up-regulation of type I hypersensitivity
has exact synonym: upregulation of type I hypersensitivity
has narrow synonym: activation of type I hypersensitivity
has narrow synonym: stimulation of type I hypersensitivity
has OBO namespace: biological_process
id: GO:0001812
type: Class
subclass of: regulation of type I hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0016068

regulation of antibody-dependent cellular cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.
has exact synonym: regulation of antibody dependent cell death
has exact synonym: regulation of antibody dependent cell killing
has exact synonym: regulation of antibody-dependent cell death
has exact synonym: regulation of antibody-dependent cell killing
has OBO namespace: biological_process
id: GO:0001813
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: Restriction
  on property: RO_0002211
  some values from: antibody-dependent cellular cytotoxicity

negative regulation of antibody-dependent cellular cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.
has exact synonym: down regulation of antibody-dependent cellular cytotoxicity
has exact synonym: down-regulation of antibody-dependent cellular cytotoxicity
has exact synonym: downregulation of antibody-dependent cellular cytotoxicity
has exact synonym: negative regulation of antibody dependent cell death
has exact synonym: negative regulation of antibody dependent cell killing
has exact synonym: negative regulation of antibody-dependent cell death
has exact synonym: negative regulation of antibody-dependent cell killing
has narrow synonym: inhibition of antibody-dependent cellular cytotoxicity
has OBO namespace: biological_process
id: GO:0001814
type: Class
subclass of: negative regulation of type IIa hypersensitivity
subclass of: regulation of antibody-dependent cellular cytotoxicity
subclass of: negative regulation of leukocyte mediated cytotoxicity
subclass of: Restriction
  on property: RO_0002212
  some values from: antibody-dependent cellular cytotoxicity

positive regulation of antibody-dependent cellular cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.
has exact synonym: positive regulation of antibody dependent cell death
has exact synonym: positive regulation of antibody dependent cell killing
has exact synonym: positive regulation of antibody-dependent cell death
has exact synonym: positive regulation of antibody-dependent cell killing
has exact synonym: up regulation of antibody-dependent cellular cytotoxicity
has exact synonym: up-regulation of antibody-dependent cellular cytotoxicity
has exact synonym: upregulation of antibody-dependent cellular cytotoxicity
has narrow synonym: activation of antibody-dependent cellular cytotoxicity
has narrow synonym: stimulation of antibody-dependent cellular cytotoxicity
has OBO namespace: biological_process
id: GO:0001815
type: Class
subclass of: positive regulation of type IIa hypersensitivity
subclass of: regulation of antibody-dependent cellular cytotoxicity
subclass of: positive regulation of leukocyte mediated cytotoxicity
subclass of: Restriction
  on property: RO_0002213
  some values from: antibody-dependent cellular cytotoxicity

cytokine production
IAO_0000115: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has narrow synonym: interferon production
has narrow synonym: interleukin production
has OBO namespace: biological_process
id: GO:0001816
in subset: goslim pir
type: Class
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
subclass of: GO_0044707

regulation of cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of production of a cytokine.
has OBO namespace: biological_process
id: GO:0001817
type: Class
subclass of: GO_0051239
subclass of: Restriction
  on property: RO_0002211
  some values from: cytokine production

negative regulation of cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the rate of production of a cytokine.
has exact synonym: down regulation of cytokine production
has exact synonym: down-regulation of cytokine production
has exact synonym: downregulation of cytokine production
has narrow synonym: inhibition of cytokine production
has OBO namespace: biological_process
id: GO:0001818
type: Class
subclass of: regulation of cytokine production
subclass of: GO_0051241
subclass of: Restriction
  on property: RO_0002212
  some values from: cytokine production

positive regulation of cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate or extent of production of a cytokine.
has exact synonym: up regulation of cytokine production
has exact synonym: up-regulation of cytokine production
has exact synonym: upregulation of cytokine production
has narrow synonym: activation of cytokine production
has narrow synonym: stimulation of cytokine production
has OBO namespace: biological_process
id: GO:0001819
type: Class
subclass of: regulation of cytokine production
subclass of: GO_0051240
subclass of: Restriction
  on property: RO_0002213
  some values from: cytokine production

serotonin secretion
IAO_0000115: The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
has exact synonym: 5-HT secretion
has exact synonym: 5-hydroxytryptamine secretion
has OBO namespace: biological_process
has related synonym: serotonin release
id: GO:0001820
type: Class
subclass of: GO_0006837
subclass of: GO_0023061
subclass of: GO_0032940

histamine secretion
IAO_0000115: The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.
has OBO namespace: biological_process
id: GO:0001821
type: Class
subclass of: GO_0046903
subclass of: GO_0051608

kidney development
IAO_0000115: The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
has db xref: Wikipedia:Kidney_development
has OBO namespace: biological_process
has related synonym: nephrogenesis
id: GO:0001822
type: Class
subclass of: GO_0048513
subclass of: Restriction
  on property: part_of
  some values from: GO_0072001

mesonephros development
IAO_0000115: The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
has OBO namespace: biological_process
id: GO:0001823
type: Class
subclass of: kidney development

blastocyst development
IAO_0000115: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
has OBO namespace: biological_process
id: GO:0001824
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: in utero embryonic development

blastocyst formation
IAO_0000115: The initial formation of a blastocyst from a solid ball of cells known as a morula.
has OBO namespace: biological_process
id: GO:0001825
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: blastocyst development

inner cell mass cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.
has OBO namespace: biological_process
id: GO:0001826
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
subclass of: GO_0030154
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: blastocyst formation

inner cell mass cell fate commitment
IAO_0000115: The cell fate commitment of precursor cells that will become inner cell mass cells.
has OBO namespace: biological_process
id: GO:0001827
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'.
subclass of: GO_0045165
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: inner cell mass cell differentiation

inner cell mass cellular morphogenesis
IAO_0000115: The morphogenesis of cells in the inner cell mass.
has OBO namespace: biological_process
id: GO:0001828
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
subclass of: cell morphogenesis involved in differentiation
subclass of: GO_0048598
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: inner cell mass cell differentiation

trophectodermal cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
has exact synonym: trophectoderm cell differentiation
has OBO namespace: biological_process
id: GO:0001829
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
subclass of: GO_0030154
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: blastocyst formation

trophectodermal cell fate commitment
IAO_0000115: The cell fate commitment of precursor cells that will become trophectoderm cells.
has exact synonym: trophectoderm cell fate commitment
has OBO namespace: biological_process
id: GO:0001830
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
subclass of: GO_0045165
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: trophectodermal cell differentiation

trophectodermal cellular morphogenesis
IAO_0000115: The morphogenesis of trophectoderm cells.
has exact synonym: trophectoderm cellular morphogenesis
has OBO namespace: biological_process
id: GO:0001831
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
subclass of: cell morphogenesis involved in differentiation
subclass of: GO_0048598
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: trophectodermal cell differentiation

blastocyst growth
IAO_0000115: An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
has OBO namespace: biological_process
id: GO:0001832
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
subclass of: GO_0048589
subclass of: Restriction
  on property: part_of
  some values from: blastocyst development

inner cell mass cell proliferation
IAO_0000115: The proliferation of cells in the inner cell mass.
has OBO namespace: biological_process
id: GO:0001833
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
subclass of: GO_0008283
subclass of: Restriction
  on property: part_of
  some values from: blastocyst growth

trophectodermal cell proliferation
IAO_0000115: The proliferation of cells in the trophectoderm.
has exact synonym: trophectoderm cell proliferation
has OBO namespace: biological_process
id: GO:0001834
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
subclass of: GO_0008283
subclass of: Restriction
  on property: part_of
  some values from: blastocyst growth

blastocyst hatching
IAO_0000115: The hatching of the cellular blastocyst from the zona pellucida.
has OBO namespace: biological_process
id: GO:0001835
type: Class
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'.
subclass of: GO_0035188
subclass of: Restriction
  on property: part_of
  some values from: blastocyst development

release of cytochrome c from mitochondria
IAO_0000115: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
has OBO namespace: biological_process
id: GO:0001836
type: Class
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process.
subclass of: GO_0008637
subclass of: Restriction
  on property: part_of
  some values from: GO_0097190

epithelial to mesenchymal transition
IAO_0000115: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
has exact synonym: EMT
has exact synonym: epithelial-mesenchymal transition
has OBO namespace: biological_process
id: GO:0001837
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: Restriction
  on property: part_of
  some values from: GO_0014031

embryonic epithelial tube formation
IAO_0000115: The morphogenesis of an embryonic epithelium into a tube-shaped structure.
has OBO namespace: biological_process
id: GO:0001838
type: Class
subclass of: GO_0072175
subclass of: Restriction
  on property: part_of
  some values from: GO_0016331

neural plate morphogenesis
IAO_0000115: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
has OBO namespace: biological_process
id: GO:0001839
type: Class
subclass of: GO_0016331
subclass of: Restriction
  on property: part_of
  some values from: neural plate development

neural plate development
IAO_0000115: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
has OBO namespace: biological_process
id: GO:0001840
type: Class
subclass of: GO_0060429
subclass of: Restriction
  on property: part_of
  some values from: GO_0043009

neural tube formation
IAO_0000115: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
has alternative id: GO:0001679
has db xref: Wikipedia:Neurulation
has exact synonym: neural tube morphogenesis
has exact synonym: neurulation
has OBO namespace: biological_process
id: GO:0001841
type: Class
subclass of: embryonic epithelial tube formation
subclass of: Restriction
  on property: part_of
  some values from: GO_0021915

neural fold formation
IAO_0000115: The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.
has OBO namespace: biological_process
has related synonym: neural groove formation
id: GO:0001842
type: Class
subclass of: GO_0016331
subclass of: GO_0048646
subclass of: GO_0060571
subclass of: Restriction
  on property: part_of
  some values from: GO_0014020

neural tube closure
IAO_0000115: The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
has OBO namespace: biological_process
id: GO:0001843
type: Class
subclass of: GO_0060606
subclass of: Restriction
  on property: part_of
  some values from: GO_0014020

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
IAO_0000115: The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.
has db xref: Reactome:REACT_101395
has db xref: Reactome:REACT_101818
has db xref: Reactome:REACT_102379
has db xref: Reactome:REACT_104
has db xref: Reactome:REACT_105818
has db xref: Reactome:REACT_105883
has db xref: Reactome:REACT_109143
has db xref: Reactome:REACT_110253
has db xref: Reactome:REACT_110902
has db xref: Reactome:REACT_112264
has db xref: Reactome:REACT_112484
has db xref: Reactome:REACT_112773
has db xref: Reactome:REACT_113120
has db xref: Reactome:REACT_113968
has db xref: Reactome:REACT_115488
has db xref: Reactome:REACT_1286
has db xref: Reactome:REACT_1585
has db xref: Reactome:REACT_2046
has db xref: Reactome:REACT_32202
has db xref: Reactome:REACT_32704
has db xref: Reactome:REACT_600
has db xref: Reactome:REACT_750
has db xref: Reactome:REACT_78961
has db xref: Reactome:REACT_81932
has db xref: Reactome:REACT_83771
has db xref: Reactome:REACT_85921
has db xref: Reactome:REACT_87251
has db xref: Reactome:REACT_87865
has db xref: Reactome:REACT_89314
has db xref: Reactome:REACT_91622
has db xref: Reactome:REACT_92580
has db xref: Reactome:REACT_94530
has db xref: Reactome:REACT_95929
has db xref: Reactome:REACT_97369
has db xref: Reactome:REACT_97409
has db xref: Reactome:REACT_97453
has db xref: Reactome:REACT_99030
has db xref: Reactome:REACT_99700
has narrow synonym: insertion of proteins into mitochondrial membranes during the induction of apoptosis
has narrow synonym: protein insertion into mitochondrial membrane during induction of apoptosis
has narrow synonym: protein insertion into mitochondrial membrane involved in induction of apoptosis
has narrow synonym: protein insertion into mitochondrion membrane during induction of apoptosis
has OBO namespace: biological_process
id: GO:0001844
type: Class
comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program.
subclass of: GO_0051204
subclass of: Restriction
  on property: part_of
  some values from: GO_0097190
subclass of: Restriction
  on property: part_of
  some values from: GO_0097345

phagolysosome assembly
IAO_0000115: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
has OBO namespace: biological_process
has related synonym: late phagosome biosynthesis
has related synonym: late phagosome formation
has related synonym: phagolysosome formation
id: GO:0001845
type: Class
subclass of: GO_0070925
subclass of: Restriction
  on property: part_of
  some values from: GO_0090382
subclass of: Restriction
  on property: part_of
  some values from: GO_0006909

opsonin binding
IAO_0000115: Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.
has OBO namespace: molecular_function
id: GO:0001846
type: Class
comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties.
subclass of: GO_0005515

opsonin receptor activity
IAO_0000115: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001847
type: Class
subclass of: GO_0004888

complement binding
IAO_0000115: Interacting selectively and non-covalently with any component or product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001848
type: Class
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
subclass of: GO_0005515

complement component C1q binding
IAO_0000115: Interacting selectively and non-covalently with the C1q component of the classical complement cascade.
has OBO namespace: molecular_function
id: GO:0001849
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component C3a binding
IAO_0000115: Interacting selectively and non-covalently with the C3a product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001850
type: Class
subclass of: complement binding

complement component C3b binding
IAO_0000115: Interacting selectively and non-covalently with the C3b product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001851
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component iC3b binding
IAO_0000115: Interacting selectively and non-covalently with the iC3b product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001852
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component C3dg binding
IAO_0000115: Interacting selectively and non-covalently with the C3dg product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001853
type: Class
subclass of: complement binding

complement component C3d binding
IAO_0000115: Interacting selectively and non-covalently with the C3d product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001854
type: Class
subclass of: complement binding

complement component C4b binding
IAO_0000115: Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
has OBO namespace: molecular_function
id: GO:0001855
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component C5a binding
IAO_0000115: Interacting selectively and non-covalently with the C5a product of the complement cascade.
has OBO namespace: molecular_function
id: GO:0001856
type: Class
subclass of: complement binding

complement component C1q receptor activity
IAO_0000115: Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001857
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875

complement component iC3b receptor activity
IAO_0000115: Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001858
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875

complement component C3dg receptor activity
IAO_0000115: Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001859
type: Class
subclass of: GO_0004875

complement component C3d receptor activity
IAO_0000115: Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001860
type: Class
subclass of: GO_0004875

complement component C4b receptor activity
IAO_0000115: Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001861
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875

collectin binding
IAO_0000115: Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.
has OBO namespace: molecular_function
id: GO:0001862
type: Class
comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D).
subclass of: opsonin binding

collectin receptor activity
IAO_0000115: Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001863
type: Class
comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D).
subclass of: opsonin receptor activity

pentraxin binding
IAO_0000115: Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.
has OBO namespace: molecular_function
id: GO:0001864
type: Class
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
subclass of: opsonin binding

NK T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a NK T cell.
has exact synonym: NK T lymphocyte differentiation
has exact synonym: NK T-cell differentiation
has exact synonym: NK T-lymphocyte differentiation
has exact synonym: NKT cell differentiation
has exact synonym: NT cell differentiation
has exact synonym: natural T cell differentiation
has exact synonym: natural killer T cell differentiation
has OBO namespace: biological_process
has related synonym: NK T cell development
id: GO:0001865
type: Class
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0046632

NK T cell proliferation
IAO_0000115: The expansion of a NK T cell population by cell division.
has exact synonym: NK T lymphocyte proliferation
has exact synonym: NK T-cell proliferation
has exact synonym: NK T-lymphocyte proliferation
has exact synonym: NKT cell proliferation
has exact synonym: NT cell proliferation
has exact synonym: natural T cell proliferation
has exact synonym: natural killer T cell proliferation
has OBO namespace: biological_process
id: GO:0001866
type: Class
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
subclass of: GO_0046633

complement activation, lectin pathway
IAO_0000115: Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
has db xref: Reactome:REACT_114752
has db xref: Reactome:REACT_30334
has db xref: Reactome:REACT_31122
has db xref: Reactome:REACT_33084
has db xref: Reactome:REACT_7964
has db xref: Reactome:REACT_89631
has db xref: Reactome:REACT_96749
has exact synonym: complement cascade, lectin pathway
has OBO namespace: biological_process
id: GO:0001867
type: Class
comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
subclass of: GO_0006956
subclass of: GO_0045087

regulation of complement activation, lectin pathway
IAO_0000115: Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.
has exact synonym: regulation of complement cascade, lectin pathway
has OBO namespace: biological_process
id: GO:0001868
type: Class
subclass of: GO_0030449
subclass of: GO_0045088
subclass of: Restriction
  on property: RO_0002211
  some values from: complement activation, lectin pathway

negative regulation of complement activation, lectin pathway
IAO_0000115: Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
has exact synonym: down regulation of complement activation, lectin pathway
has exact synonym: down-regulation of complement activation, lectin pathway
has exact synonym: downregulation of complement activation, lectin pathway
has exact synonym: negative regulation of complement cascade, lectin pathway
has narrow synonym: inhibition of complement activation, lectin pathway
has OBO namespace: biological_process
id: GO:0001869
type: Class
subclass of: regulation of complement activation, lectin pathway
subclass of: GO_0045824
subclass of: GO_0045916
subclass of: Restriction
  on property: RO_0002212
  some values from: complement activation, lectin pathway

positive regulation of complement activation, lectin pathway
IAO_0000115: Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.
has exact synonym: positive regulation of complement cascade, lectin pathway
has exact synonym: up regulation of complement activation, lectin pathway
has exact synonym: up-regulation of complement activation, lectin pathway
has exact synonym: upregulation of complement activation, lectin pathway
has narrow synonym: activation of complement activation, lectin pathway
has narrow synonym: stimulation of complement activation, lectin pathway
has OBO namespace: biological_process
id: GO:0001870
type: Class
subclass of: regulation of complement activation, lectin pathway
subclass of: GO_0045089
subclass of: GO_0045917
subclass of: Restriction
  on property: RO_0002213
  some values from: complement activation, lectin pathway

pattern binding
IAO_0000115: Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.
has broad synonym: pattern recognition activity
has OBO namespace: molecular_function
id: GO:0001871
in subset: goslim pir
in subset: gosubset prok
type: Class
comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead.
subclass of: GO_0005488

(1->3)-beta-D-glucan binding
IAO_0000115: Interacting selectively and non-covalently with (1->3)-beta-D-glucans.
has alternative id: GO:0080087
has exact synonym: 1,3-beta-D-glucan binding
has narrow synonym: callose binding
has narrow synonym: zymosan binding
has OBO namespace: molecular_function
id: GO:0001872
type: Class
subclass of: GO_0030247

polysaccharide receptor activity
IAO_0000115: Combining with a polysaccharide to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0001873
type: Class
subclass of: GO_0008329

(1->3)-beta-D-glucan receptor activity
IAO_0000115: Combining with (1->3)-beta-D-glucans to initiate a change in cell activity.
has exact synonym: (1,3)-beta-D-glucan receptor activity
has exact synonym: 1,3-beta-D-glucan receptor activity
has exact synonym: beta-1,3-D-glucan receptor activity
has narrow synonym: zymosan receptor activity
has OBO namespace: molecular_function
id: GO:0001874
type: Class
subclass of: polysaccharide receptor activity

lipopolysaccharide receptor activity
IAO_0000115: Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
has broad synonym: endotoxin receptor activity
has exact synonym: LPS receptor activity
has OBO namespace: molecular_function
id: GO:0001875
type: Class
subclass of: GO_0008329

lipoarabinomannan binding
IAO_0000115: Interacting selectively and non-covalently with lipoarabinomannan.
has exact synonym: LAM binding
has OBO namespace: molecular_function
id: GO:0001876
type: Class
subclass of: pattern binding
subclass of: GO_0034235

lipoarabinomannan receptor activity
IAO_0000115: Combining with lipoarabinomannan to initiate a change in cell activity.
has exact synonym: LAM receptor activity
has OBO namespace: molecular_function
id: GO:0001877
type: Class
subclass of: GO_0008329

response to yeast
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
has OBO namespace: biological_process
id: GO:0001878
type: Class
subclass of: GO_0009620

detection of yeast
IAO_0000115: The series of events in which a stimulus from a yeast is received and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0001879
type: Class
subclass of: response to yeast
subclass of: GO_0016046

Mullerian duct regression
IAO_0000115: The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.
has OBO namespace: biological_process
id: GO:0001880
type: Class
subclass of: developmental process involved in reproduction
subclass of: GO_0060033
subclass of: Restriction
  on property: part_of
  some values from: GO_0046661

receptor recycling
IAO_0000115: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
has OBO namespace: biological_process
id: GO:0001881
type: Class
subclass of: GO_0043112
subclass of: Restriction
  on property: part_of
  some values from: GO_0023051

nucleoside binding
IAO_0000115: Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
has OBO namespace: molecular_function
id: GO:0001882
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0036094
subclass of: GO_0097159
subclass of: GO_1901363

purine nucleoside binding
IAO_0000115: Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.
has OBO namespace: molecular_function
id: GO:0001883
type: Class
subclass of: nucleoside binding

pyrimidine nucleoside binding
IAO_0000115: Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose.
has OBO namespace: molecular_function
id: GO:0001884
type: Class
subclass of: nucleoside binding

endothelial cell development
IAO_0000115: The progression of an endothelial cell over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0001885
type: Class
subclass of: epithelial cell development
subclass of: Restriction
  on property: part_of
  some values from: GO_0045446

endothelial cell morphogenesis
IAO_0000115: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
has OBO namespace: biological_process
id: GO:0001886
type: Class
subclass of: epithelial cell morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: endothelial cell development

selenium compound metabolic process
IAO_0000115: The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
has exact synonym: selenium compound metabolism
has exact synonym: selenium metabolic process
has exact synonym: selenium metabolism
has OBO namespace: biological_process
id: GO:0001887
in subset: gosubset prok
type: Class
subclass of: GO_0044237

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.
has db xref: EC:2.4.1.223
has db xref: MetaCyc:2.4.1.223-RXN
has exact synonym: UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: alpha-1,4-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-N-acetylglucosaminyltransferase I activity
has exact synonym: alpha1,4-N-acetylglucosaminyltransferase activity
has exact synonym: glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
has OBO namespace: molecular_function
id: GO:0001888
type: Class
subclass of: GO_0008375

liver development
IAO_0000115: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
has OBO namespace: biological_process
id: GO:0001889
type: Class
subclass of: GO_0048513
subclass of: Restriction
  on property: part_of
  some values from: GO_0061008

placenta development
IAO_0000115: The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has exact synonym: placental development
has exact synonym: placentation
has OBO namespace: biological_process
id: GO:0001890
type: Class
subclass of: GO_0048513

phagocytic cup
IAO_0000115: An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
has OBO namespace: cellular_component
id: GO:0001891
type: Class
subclass of: GO_0044459

embryonic placenta development
IAO_0000115: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has exact synonym: fetal placenta development
has OBO namespace: biological_process
id: GO:0001892
type: Class
subclass of: GO_0048568
subclass of: Restriction
  on property: part_of
  some values from: in utero embryonic development
subclass of: Restriction
  on property: part_of
  some values from: placenta development

maternal placenta development
IAO_0000115: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has OBO namespace: biological_process
has related synonym: decidua development
id: GO:0001893
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: placenta development

tissue homeostasis
IAO_0000115: A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
has narrow synonym: tissue maintenance
has OBO namespace: biological_process
id: GO:0001894
type: Class
subclass of: GO_0060249
subclass of: Restriction
  on property: part_of
  some values from: GO_0048871

retina homeostasis
IAO_0000115: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.
has OBO namespace: biological_process
id: GO:0001895
type: Class
subclass of: tissue homeostasis

autolysis
IAO_0000115: The spontaneous death by lysis of bacteria in response to environmental conditions.
has db xref: Wikipedia:Autolysis
has OBO namespace: biological_process
id: GO:0001896
in subset: gosubset prok
type: Class
subclass of: GO_0019835

cytolysis by symbiont of host cells
IAO_0000115: The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: cytolysis by organism of host cells
has OBO namespace: biological_process
id: GO:0001897
in subset: gosubset prok
type: Class
subclass of: killing by symbiont of host cells
subclass of: GO_0051801

regulation of cytolysis by symbiont of host cells
IAO_0000115: Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: regulation by symbiont of cytolysis of host cells
has OBO namespace: biological_process
id: GO:0001898
in subset: gosubset prok
type: Class
subclass of: GO_0051802
subclass of: Restriction
  on property: RO_0002211
  some values from: cytolysis by symbiont of host cells

negative regulation of cytolysis by symbiont of host cells
IAO_0000115: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: down regulation by symbiont of cytolysis of host cells
has exact synonym: down-regulation by symbiont of cytolysis of host cells
has exact synonym: downregulation by symbiont of cytolysis of host cells
has exact synonym: negative regulation by symbiont of cytolysis of host cells
has narrow synonym: inhibition by symbiont of cytolysis of host cells
has OBO namespace: biological_process
id: GO:0001899
in subset: gosubset prok
type: Class
subclass of: regulation of cytolysis by symbiont of host cells
subclass of: GO_0051803
subclass of: Restriction
  on property: RO_0002212
  some values from: cytolysis by symbiont of host cells

positive regulation of cytolysis by symbiont of host cells
IAO_0000115: Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: positive regulation by symbiont of cytolysis of host cells
has exact synonym: up regulation by symbiont of cytolysis of host cells
has exact synonym: up-regulation by symbiont of cytolysis of host cells
has exact synonym: upregulation by symbiont of cytolysis of host cells
has narrow synonym: activation by symbiont of cytolysis of host cells
has narrow synonym: stimulation by symbiont of cytolysis of host cells
has OBO namespace: biological_process
id: GO:0001900
in subset: gosubset prok
type: Class
subclass of: regulation of cytolysis by symbiont of host cells
subclass of: GO_0051804
subclass of: Restriction
  on property: RO_0002213
  some values from: cytolysis by symbiont of host cells

activation of membrane attack complex
IAO_0000115: The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
has exact synonym: MAC assembly
has exact synonym: MAC formation
has exact synonym: activation of MAC
has exact synonym: membrane attack complex assembly
has exact synonym: membrane attack complex formation
has narrow synonym: activation of TCC
has narrow synonym: activation of terminal complement complex
has narrow synonym: activation of the terminal complement cascade
has OBO namespace: biological_process
id: GO:0001905
type: Class
subclass of: GO_0006956

cell killing
IAO_0000115: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
has OBO namespace: biological_process
has related synonym: necrosis
id: GO:0001906
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0008150

killing by symbiont of host cells
IAO_0000115: Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has OBO namespace: biological_process
id: GO:0001907
in subset: gosubset prok
type: Class
subclass of: GO_0044004
subclass of: GO_0051883

leukocyte mediated cytotoxicity
IAO_0000115: The directed killing of a target cell by a leukocyte.
has exact synonym: immune cell mediated cell death
has exact synonym: immune cell mediated cell killing
has exact synonym: immune cell mediated cytotoxicity
has exact synonym: leucocyte mediated cytotoxicity
has OBO namespace: biological_process
id: GO:0001909
type: Class
comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
subclass of: cell killing
subclass of: immune effector process
subclass of: GO_0044699

regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
has exact synonym: regulation of immune cell mediated cell death
has exact synonym: regulation of immune cell mediated cell killing
has exact synonym: regulation of immune cell mediated cytotoxicity
has exact synonym: regulation of leucocyte mediated cytotoxicity
has OBO namespace: biological_process
id: GO:0001910
type: Class
subclass of: regulation of immune effector process
subclass of: GO_0031341
subclass of: Restriction
  on property: RO_0002211
  some values from: leukocyte mediated cytotoxicity

negative regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
has exact synonym: down regulation of leukocyte mediated cytotoxicity
has exact synonym: down-regulation of leukocyte mediated cytotoxicity
has exact synonym: downregulation of leukocyte mediated cytotoxicity
has exact synonym: negative regulation of immune cell mediated cytotoxicity
has exact synonym: negative regulation of leucocyte mediated cytotoxicity
has narrow synonym: inhibition of leukocyte mediated cytotoxicity
has OBO namespace: biological_process
id: GO:0001911
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: negative regulation of immune effector process
subclass of: GO_0031342
subclass of: Restriction
  on property: RO_0002212
  some values from: leukocyte mediated cytotoxicity

positive regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
has exact synonym: positive regulation of immune cell mediated cytotoxicity
has exact synonym: positive regulation of leucocyte mediated cytotoxicity
has exact synonym: up regulation of leukocyte mediated cytotoxicity
has exact synonym: up-regulation of leukocyte mediated cytotoxicity
has exact synonym: upregulation of leukocyte mediated cytotoxicity
has narrow synonym: activation of leukocyte mediated cytotoxicity
has narrow synonym: stimulation of leukocyte mediated cytotoxicity
has OBO namespace: biological_process
id: GO:0001912
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: positive regulation of immune effector process
subclass of: GO_0031343
subclass of: Restriction
  on property: RO_0002213
  some values from: leukocyte mediated cytotoxicity

T cell mediated cytotoxicity
IAO_0000115: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: T cell mediated apoptosis
has exact synonym: T cell mediated cell death
has exact synonym: T cell mediated cell killing
has exact synonym: T lymphocyte mediated cytotoxicity
has exact synonym: T-cell mediated apoptosis
has exact synonym: T-cell mediated cell death
has exact synonym: T-cell mediated cell killing
has exact synonym: T-cell mediated cytotoxicity
has exact synonym: T-lymphocyte mediated cytotoxicity
has OBO namespace: biological_process
has related synonym: T cell mediated cytolysis
id: GO:0001913
type: Class
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
subclass of: leukocyte mediated cytotoxicity
subclass of: T cell mediated immunity

regulation of T cell mediated cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
has exact synonym: regulation of T cell mediated apoptosis
has exact synonym: regulation of T cell mediated cell death
has exact synonym: regulation of T cell mediated cell killing
has exact synonym: regulation of T lymphocyte mediated cytotoxicity
has exact synonym: regulation of T-cell mediated apoptosis
has exact synonym: regulation of T-cell mediated cell death
has exact synonym: regulation of T-cell mediated cell killing
has exact synonym: regulation of T-cell mediated cytotoxicity
has exact synonym: regulation of T-lymphocyte mediated cytotoxicity
has OBO namespace: biological_process
has related synonym: regulation of T cell mediated cytolysis
has related synonym: regulation of T-cell mediated cytolysis
id: GO:0001914
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell mediated cytotoxicity

negative regulation of T cell mediated cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
has exact synonym: down regulation of T cell mediated cytotoxicity
has exact synonym: down-regulation of T cell mediated cytotoxicity
has exact synonym: downregulation of T cell mediated cytotoxicity
has exact synonym: negative regulation of T cell mediated apoptosis
has exact synonym: negative regulation of T cell mediated cell death
has exact synonym: negative regulation of T cell mediated cell killing
has exact synonym: negative regulation of T lymphocyte mediated cytotoxicity
has exact synonym: negative regulation of T-cell mediated apoptosis
has exact synonym: negative regulation of T-cell mediated cell death
has exact synonym: negative regulation of T-cell mediated cell killing
has exact synonym: negative regulation of T-cell mediated cytotoxicity
has exact synonym: negative regulation of T-lymphocyte mediated cytotoxicity
has narrow synonym: inhibition of T cell mediated cytotoxicity
has OBO namespace: biological_process
has related synonym: negative regulation of T cell mediated cytolysis
has related synonym: negative regulation of T-cell mediated cytolysis
id: GO:0001915
type: Class
subclass of: negative regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated cytotoxicity
subclass of: negative regulation of T cell mediated immunity
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
has exact synonym: positive regulation of T cell mediated apoptosis
has exact synonym: positive regulation of T cell mediated cell death
has exact synonym: positive regulation of T cell mediated cell killing
has exact synonym: positive regulation of T lymphocyte mediated cytotoxicity
has exact synonym: positive regulation of T-cell mediated apoptosis
has exact synonym: positive regulation of T-cell mediated cell death
has exact synonym: positive regulation of T-cell mediated cell killing
has exact synonym: positive regulation of T-cell mediated cytotoxicity
has exact synonym: positive regulation of T-lymphocyte mediated cytotoxicity
has exact synonym: up regulation of T cell mediated cytotoxicity
has exact synonym: up-regulation of T cell mediated cytotoxicity
has exact synonym: upregulation of T cell mediated cytotoxicity
has narrow synonym: activation of T cell mediated cytotoxicity
has narrow synonym: stimulation of T cell mediated cytotoxicity
has OBO namespace: biological_process
has related synonym: positive regulation of T cell mediated cytolysis
has related synonym: positive regulation of T-cell mediated cytolysis
id: GO:0001916
type: Class
subclass of: positive regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated cytotoxicity
subclass of: positive regulation of T cell mediated immunity
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell mediated cytotoxicity

photoreceptor inner segment
IAO_0000115: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
has OBO namespace: cellular_component
id: GO:0001917
in subset: goslim pir
type: Class
subclass of: GO_0044464

farnesylated protein binding
IAO_0000115: Interacting selectively and non-covalently with a farnesylated protein.
has OBO namespace: molecular_function
id: GO:0001918
type: Class
subclass of: GO_0005515

regulation of receptor recycling
IAO_0000115: Any process that modulates the frequency, rate, or extent of receptor recycling.
has OBO namespace: biological_process
id: GO:0001919
type: Class
subclass of: GO_0023051
subclass of: GO_0031323
subclass of: GO_0060255
subclass of: Restriction
  on property: RO_0002211
  some values from: receptor recycling

negative regulation of receptor recycling
IAO_0000115: Any process that stops, prevents, or reduces the rate of receptor recycling.
has exact synonym: down regulation of receptor recycling
has exact synonym: down-regulation of receptor recycling
has exact synonym: downregulation of receptor recycling
has narrow synonym: inhibition of receptor recycling
has OBO namespace: biological_process
id: GO:0001920
type: Class
subclass of: regulation of receptor recycling
subclass of: GO_0010605
subclass of: GO_0023057
subclass of: GO_0031324
subclass of: Restriction
  on property: RO_0002212
  some values from: receptor recycling

positive regulation of receptor recycling
IAO_0000115: Any process that activates or increases the frequency, rate or extent of receptor recycling.
has exact synonym: up regulation of receptor recycling
has exact synonym: up-regulation of receptor recycling
has exact synonym: upregulation of receptor recycling
has narrow synonym: activation of receptor recycling
has narrow synonym: stimulation of receptor recycling
has OBO namespace: biological_process
id: GO:0001921
type: Class
subclass of: regulation of receptor recycling
subclass of: GO_0010604
subclass of: GO_0023056
subclass of: GO_0031325
subclass of: Restriction
  on property: RO_0002213
  some values from: receptor recycling

B-1 B cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: B-1 B lymphocyte homeostasis
has exact synonym: B-1 B-cell homeostasis
has exact synonym: B-1 B-lymphocyte homeostasis
has OBO namespace: biological_process
id: GO:0001922
type: Class
comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
subclass of: B cell homeostasis

B-1 B cell differentiation
IAO_0000115: The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: B-1 B lymphocyte differentiation
has exact synonym: B-1 B-cell differentiation
has exact synonym: B-1 B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: B-1 B cell development
id: GO:0001923
type: Class
subclass of: mature B cell differentiation

regulation of B-1 B cell differentiation
IAO_0000115: Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: regulation of B-1 B lymphocyte differentiation
has exact synonym: regulation of B-1 B-cell differentiation
has exact synonym: regulation of B-1 B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: regulation of B-1 B cell development
id: GO:0001924
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0045577
subclass of: Restriction
  on property: RO_0002211
  some values from: B-1 B cell differentiation

negative regulation of B-1 B cell differentiation
IAO_0000115: Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.
has exact synonym: down regulation of B-1 B cell differentiation
has exact synonym: down-regulation of B-1 B cell differentiation
has exact synonym: downregulation of B-1 B cell differentiation
has exact synonym: negative regulation of B-1 B lymphocyte differentiation
has exact synonym: negative regulation of B-1 B-cell differentiation
has exact synonym: negative regulation of B-1 B-lymphocyte differentiation
has narrow synonym: inhibition of B-1 B cell differentiation
has OBO namespace: biological_process
has related synonym: negative regulation of B-1 B cell development
id: GO:0001925
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: regulation of B-1 B cell differentiation
subclass of: GO_0045578
subclass of: Restriction
  on property: RO_0002212
  some values from: B-1 B cell differentiation

positive regulation of B-1 B cell differentiation
IAO_0000115: Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation.
has exact synonym: positive regulation of B-1 B lymphocyte differentiation
has exact synonym: positive regulation of B-1 B-cell differentiation
has exact synonym: positive regulation of B-1 B-lymphocyte differentiation
has exact synonym: up regulation of B-1 B cell differentiation
has exact synonym: up-regulation of B-1 B cell differentiation
has exact synonym: upregulation of B-1 B cell differentiation
has narrow synonym: activation of B-1 B cell differentiation
has narrow synonym: stimulation of B-1 B cell differentiation
has OBO namespace: biological_process
has related synonym: positive regulation of B-1 B cell development
id: GO:0001926
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: regulation of B-1 B cell differentiation
subclass of: GO_0045579
subclass of: Restriction
  on property: RO_0002213
  some values from: B-1 B cell differentiation

exocyst assembly
IAO_0000115: The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.
has OBO namespace: biological_process
id: GO:0001927
type: Class
subclass of: GO_0043623
subclass of: Restriction
  on property: part_of
  some values from: GO_0006904

regulation of exocyst assembly
IAO_0000115: Any process that modulates the frequency, rate or extent of exocyst assembly.
has OBO namespace: biological_process
id: GO:0001928
type: Class
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
subclass of: GO_0017157
subclass of: GO_0043254
subclass of: Restriction
  on property: RO_0002211
  some values from: exocyst assembly

negative regulation of exocyst assembly
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of exocyst assembly.
has exact synonym: down regulation of exocyst assembly
has exact synonym: down-regulation of exocyst assembly
has exact synonym: downregulation of exocyst assembly
has narrow synonym: inhibition of exocyst assembly
has OBO namespace: biological_process
id: GO:0001929
type: Class
subclass of: regulation of exocyst assembly
subclass of: GO_0031333
subclass of: Restriction
  on property: RO_0002212
  some values from: exocyst assembly

positive regulation of exocyst assembly
IAO_0000115: Any process that increases the rate or extent of exocyst assembly.
has exact synonym: up regulation of exocyst assembly
has exact synonym: up-regulation of exocyst assembly
has exact synonym: upregulation of exocyst assembly
has narrow synonym: activation of exocyst assembly
has narrow synonym: stimulation of exocyst assembly
has OBO namespace: biological_process
id: GO:0001930
type: Class
subclass of: regulation of exocyst assembly
subclass of: GO_0031334
subclass of: Restriction
  on property: RO_0002213
  some values from: exocyst assembly

uropod
IAO_0000115: A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.
has exact synonym: uropodium
has OBO namespace: cellular_component
has related synonym: distal pole complex
has related synonym: retractile pole
id: GO:0001931
type: Class
subclass of: GO_0042995
subclass of: Restriction
  on property: part_of
  some values from: GO_0031254

regulation of protein phosphorylation
IAO_0000115: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
has exact synonym: regulation of protein amino acid phosphorylation
has OBO namespace: biological_process
id: GO:0001932
in subset: gosubset prok
type: Class
subclass of: GO_0031399
subclass of: GO_0042325
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006468

negative regulation of protein phosphorylation
IAO_0000115: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
has exact synonym: down regulation of protein amino acid phosphorylation
has exact synonym: down-regulation of protein amino acid phosphorylation
has exact synonym: downregulation of protein amino acid phosphorylation
has exact synonym: negative regulation of protein amino acid phosphorylation
has narrow synonym: inhibition of protein amino acid phosphorylation
has OBO namespace: biological_process
id: GO:0001933
in subset: gosubset prok
type: Class
subclass of: regulation of protein phosphorylation
subclass of: GO_0031400
subclass of: GO_0042326
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0006468

positive regulation of protein phosphorylation
IAO_0000115: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
has exact synonym: positive regulation of protein amino acid phosphorylation
has exact synonym: up regulation of protein amino acid phosphorylation
has exact synonym: up-regulation of protein amino acid phosphorylation
has exact synonym: upregulation of protein amino acid phosphorylation
has narrow synonym: activation of protein amino acid phosphorylation
has narrow synonym: stimulation of protein amino acid phosphorylation
has OBO namespace: biological_process
id: GO:0001934
in subset: gosubset prok
type: Class
subclass of: regulation of protein phosphorylation
subclass of: GO_0031401
subclass of: GO_0042327
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0006468

endothelial cell proliferation
IAO_0000115: The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
has OBO namespace: biological_process
id: GO:0001935
type: Class
subclass of: GO_0050673

regulation of endothelial cell proliferation
IAO_0000115: Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.
has OBO namespace: biological_process
id: GO:0001936
type: Class
subclass of: GO_0050678
subclass of: Restriction
  on property: RO_0002211
  some values from: endothelial cell proliferation

negative regulation of endothelial cell proliferation
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
has exact synonym: down regulation of endothelial cell proliferation
has exact synonym: down-regulation of endothelial cell proliferation
has exact synonym: downregulation of endothelial cell proliferation
has narrow synonym: inhibition of endothelial cell proliferation
has OBO namespace: biological_process
id: GO:0001937
type: Class
subclass of: regulation of endothelial cell proliferation
subclass of: GO_0050680
subclass of: Restriction
  on property: RO_0002212
  some values from: endothelial cell proliferation

positive regulation of endothelial cell proliferation
IAO_0000115: Any process that activates or increases the rate or extent of endothelial cell proliferation.
has exact synonym: up regulation of endothelial cell proliferation
has exact synonym: up-regulation of endothelial cell proliferation
has exact synonym: upregulation of endothelial cell proliferation
has narrow synonym: activation of endothelial cell proliferation
has narrow synonym: stimulation of endothelial cell proliferation
has OBO namespace: biological_process
id: GO:0001938
type: Class
subclass of: regulation of endothelial cell proliferation
subclass of: GO_0050679
subclass of: Restriction
  on property: RO_0002213
  some values from: endothelial cell proliferation

female pronucleus
IAO_0000115: The pronucleus originating from the ovum that is being fertilized.
has OBO namespace: cellular_component
id: GO:0001939
type: Class
subclass of: GO_0045120

male pronucleus
IAO_0000115: The pronucleus originating from the spermatozoa that was involved in fertilization.
has OBO namespace: cellular_component
id: GO:0001940
type: Class
subclass of: GO_0045120

postsynaptic membrane organization
IAO_0000115: The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
has exact synonym: post-synaptic membrane organization
has exact synonym: postsynaptic membrane organisation
has OBO namespace: biological_process
id: GO:0001941
type: Class
subclass of: GO_0016044

hair follicle development
IAO_0000115: The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
has alternative id: GO:0001943
has OBO namespace: biological_process
id: GO:0001942
type: Class
subclass of: GO_0008544
subclass of: GO_0022405

vasculature development
IAO_0000115: The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
has OBO namespace: biological_process
has related synonym: vascular system development
id: GO:0001944
type: Class
subclass of: GO_0048731
subclass of: Restriction
  on property: part_of
  some values from: GO_0072358

lymph vessel development
IAO_0000115: The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0001945
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: vasculature development

lymphangiogenesis
IAO_0000115: Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
has db xref: Wikipedia:Lymphangiogenesis
has exact synonym: lymph vessel formation
has OBO namespace: biological_process
id: GO:0001946
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0036303

heart looping
IAO_0000115: The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration.
has exact synonym: cardiac looping
has OBO namespace: biological_process
id: GO:0001947
type: Class
subclass of: GO_0035239
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0061371
subclass of: Restriction
  on property: part_of
  some values from: embryonic heart tube morphogenesis

glycoprotein binding
IAO_0000115: Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.
has OBO namespace: molecular_function
id: GO:0001948
type: Class
subclass of: GO_0005515

sebaceous gland cell differentiation
IAO_0000115: The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.
has narrow synonym: sebocytes differentiation
has OBO namespace: biological_process
id: GO:0001949
type: Class
subclass of: GO_0009913
subclass of: Restriction
  on property: part_of
  some values from: GO_0048733

plasma membrane enriched fraction
IAO_0000115: OBSOLETE: The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes.
consider: GO:0005886
has OBO namespace: cellular_component
has related synonym: PME fraction
id: GO:0001950
type: Class
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
deprecated: true

intestinal D-glucose absorption
IAO_0000115: Uptake of D-glucose into the blood by absorption from the small intestine.
has OBO namespace: biological_process
id: GO:0001951
type: Class
subclass of: GO_0015758
subclass of: GO_0050892

regulation of cell-matrix adhesion
IAO_0000115: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.
has OBO namespace: biological_process
id: GO:0001952
type: Class
subclass of: GO_0010810
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0007160

negative regulation of cell-matrix adhesion
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
has exact synonym: down regulation of cell-matrix adhesion
has exact synonym: down-regulation of cell-matrix adhesion
has exact synonym: downregulation of cell-matrix adhesion
has narrow synonym: inhibition of cell-matrix adhesion
has OBO namespace: biological_process
id: GO:0001953
type: Class
subclass of: regulation of cell-matrix adhesion
subclass of: GO_0010812
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0007160

positive regulation of cell-matrix adhesion
IAO_0000115: Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
has exact synonym: up regulation of cell-matrix adhesion
has exact synonym: up-regulation of cell-matrix adhesion
has exact synonym: upregulation of cell-matrix adhesion
has narrow synonym: activation of cell-matrix adhesion
has narrow synonym: stimulation of cell-matrix adhesion
has OBO namespace: biological_process
id: GO:0001954
type: Class
subclass of: regulation of cell-matrix adhesion
subclass of: GO_0010811
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0007160

blood vessel maturation
IAO_0000115: A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
has OBO namespace: biological_process
id: GO:0001955
type: Class
subclass of: GO_0071695
subclass of: Restriction
  on property: part_of
  some values from: blood vessel development

positive regulation of neurotransmitter secretion
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
has exact synonym: up regulation of neurotransmitter secretion
has exact synonym: up-regulation of neurotransmitter secretion
has exact synonym: upregulation of neurotransmitter secretion
has narrow synonym: activation of neurotransmitter secretion
has narrow synonym: stimulation of neurotransmitter secretion
has OBO namespace: biological_process
id: GO:0001956
type: Class
subclass of: GO_0046928
subclass of: GO_0048522
subclass of: GO_0051047
subclass of: GO_0051590
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0007269

intramembranous ossification
IAO_0000115: Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.
has db xref: Wikipedia:Intramembranous_ossification
has narrow synonym: dermal ossification
has OBO namespace: biological_process
id: GO:0001957
type: Class
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
subclass of: GO_0036072

endochondral ossification
IAO_0000115: Replacement ossification wherein bone tissue replaces cartilage.
has db xref: Wikipedia:Endochondral_ossification
has OBO namespace: biological_process
id: GO:0001958
type: Class
subclass of: GO_0036075
subclass of: Restriction
  on property: part_of
  some values from: GO_0060350

regulation of cytokine-mediated signaling pathway
IAO_0000115: Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
has exact synonym: regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: regulation of cytokine mediated signaling pathway
has exact synonym: regulation of cytokine mediated signalling pathway
has OBO namespace: biological_process
id: GO:0001959
type: Class
subclass of: GO_0009966
subclass of: GO_0060759
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0019221

negative regulation of cytokine-mediated signaling pathway
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
has exact synonym: down regulation of cytokine mediated signaling pathway
has exact synonym: down-regulation of cytokine mediated signaling pathway
has exact synonym: downregulation of cytokine mediated signaling pathway
has exact synonym: negative regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: negative regulation of cytokine mediated signaling pathway
has exact synonym: negative regulation of cytokine mediated signalling pathway
has narrow synonym: inhibition of cytokine mediated signaling pathway
has OBO namespace: biological_process
id: GO:0001960
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: GO_0009968
subclass of: GO_0060761
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0019221

positive regulation of cytokine-mediated signaling pathway
IAO_0000115: Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
has exact synonym: positive regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: positive regulation of cytokine mediated signaling pathway
has exact synonym: positive regulation of cytokine mediated signalling pathway
has exact synonym: up regulation of cytokine mediated signaling pathway
has exact synonym: up-regulation of cytokine mediated signaling pathway
has exact synonym: upregulation of cytokine mediated signaling pathway
has narrow synonym: activation of cytokine mediated signaling pathway
has narrow synonym: stimulation of cytokine mediated signaling pathway
has OBO namespace: biological_process
id: GO:0001961
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: GO_0009967
subclass of: GO_0060760
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0019221

alpha-1,3-galactosyltransferase activity
IAO_0000115: Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage.
has db xref: EC:2.4.1.-
has narrow synonym: isoglobotriaosylceramide synthase
has OBO namespace: molecular_function
id: GO:0001962
type: Class
subclass of: GO_0008378

synaptic transmission, dopaminergic
IAO_0000115: The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
has OBO namespace: biological_process
id: GO:0001963
type: Class
subclass of: GO_0007270

startle response
IAO_0000115: An action or movement due to the application of a sudden unexpected stimulus.
has db xref: Wikipedia:Startle_reaction
has OBO namespace: biological_process
id: GO:0001964
type: Class
subclass of: GO_0009605
subclass of: GO_0050905

G-protein alpha-subunit binding
IAO_0000115: Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
has exact synonym: G-alpha protein subunit binding
has OBO namespace: molecular_function
id: GO:0001965
type: Class
subclass of: GO_0005515

thigmotaxis
IAO_0000115: The directed movement of a motile cell or organism in response to touch.
has broad synonym: taxis in response to mechanical stimulus
has exact synonym: stereotaxis
has exact synonym: taxis in response to touch stimulus
has OBO namespace: biological_process
id: GO:0001966
type: Class
subclass of: GO_0042330

suckling behavior
IAO_0000115: Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast.
has exact synonym: nursing behavior
has OBO namespace: biological_process
id: GO:0001967
type: Class
subclass of: GO_0007631
subclass of: GO_0051705

fibronectin binding
IAO_0000115: Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
has OBO namespace: molecular_function
id: GO:0001968
type: Class
subclass of: GO_0005515

regulation of activation of membrane attack complex
IAO_0000115: Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: regulation of MAC assembly
has exact synonym: regulation of MAC formation
has exact synonym: regulation of activation of MAC
has exact synonym: regulation of membrane attack complex assembly
has exact synonym: regulation of membrane attack complex formation
has narrow synonym: regulation of activation of TCC
has narrow synonym: regulation of activation of terminal complement complex
has narrow synonym: regulation of activation of the terminal complement cascade
has OBO namespace: biological_process
id: GO:0001969
type: Class
subclass of: GO_0030449
subclass of: Restriction
  on property: RO_0002211
  some values from: activation of membrane attack complex

positive regulation of activation of membrane attack complex
IAO_0000115: Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: positive regulation of MAC assembly
has exact synonym: positive regulation of MAC formation
has exact synonym: positive regulation of activation of MAC
has exact synonym: positive regulation of membrane attack complex assembly
has exact synonym: positive regulation of membrane attack complex formation
has exact synonym: up regulation of activation of membrane attack complex
has exact synonym: up-regulation of activation of membrane attack complex
has exact synonym: upregulation of activation of membrane attack complex
has narrow synonym: activation of activation of membrane attack complex
has narrow synonym: positive regulation of activation of TCC
has narrow synonym: positive regulation of activation of terminal complement complex
has narrow synonym: positive regulation of activation of the terminal complement cascade
has narrow synonym: stimulation of activation of membrane attack complex
has OBO namespace: biological_process
id: GO:0001970
type: Class
subclass of: regulation of activation of membrane attack complex
subclass of: GO_0045917
subclass of: Restriction
  on property: RO_0002213
  some values from: activation of membrane attack complex

negative regulation of activation of membrane attack complex
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: down regulation of activation of membrane attack complex
has exact synonym: down-regulation of activation of membrane attack complex
has exact synonym: downregulation of activation of membrane attack complex
has exact synonym: negative regulation of MAC assembly
has exact synonym: negative regulation of MAC formation
has exact synonym: negative regulation of activation of MAC
has exact synonym: negative regulation of membrane attack complex assembly
has exact synonym: negative regulation of membrane attack complex formation
has narrow synonym: inhibition of activation of membrane attack complex
has narrow synonym: negative regulation of activation of TCC
has narrow synonym: negative regulation of activation of terminal complement complex
has narrow synonym: negative regulation of activation of the terminal complement cascade
has OBO namespace: biological_process
id: GO:0001971
type: Class
subclass of: regulation of activation of membrane attack complex
subclass of: GO_0045916
subclass of: Restriction
  on property: RO_0002212
  some values from: activation of membrane attack complex

retinoic acid binding
IAO_0000115: Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.
has OBO namespace: molecular_function
id: GO:0001972
type: Class
subclass of: GO_0005501
subclass of: GO_0033293

adenosine receptor signaling pathway
IAO_0000115: The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
has exact synonym: P1 receptor signaling pathway
has exact synonym: adenosine receptor signaling pathway, G-protein coupled
has exact synonym: adenosine receptor signalling pathway
has OBO namespace: biological_process
id: GO:0001973
type: Class
subclass of: GO_0035588

blood vessel remodeling
IAO_0000115: The reorganization or renovation of existing blood vessels.
has OBO namespace: biological_process
id: GO:0001974
type: Class
subclass of: GO_0048771

response to amphetamine
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
has OBO namespace: biological_process
id: GO:0001975
type: Class
subclass of: GO_0014075

neurological system process involved in regulation of systemic arterial blood pressure
IAO_0000115: The regulation of blood pressure mediated by detection of stimuli and a neurological response.
has exact synonym: blood pressure regulation by neurological process
has exact synonym: neurological process involved in regulation of systemic arterial blood pressure
has OBO namespace: biological_process
has related synonym: fast control of arterial pressure
id: GO:0001976
type: Class
subclass of: GO_0050877
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure

renal system process involved in regulation of blood volume
IAO_0000115: A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.
has OBO namespace: biological_process
has related synonym: renal blood volume control of blood pressure
has related synonym: renal regulation of blood volume
id: GO:0001977
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: GO_0050878

regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
IAO_0000115: The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control.
has exact synonym: carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure
has OBO namespace: biological_process
has related synonym: baroreceptor feedback control of blood pressure
has related synonym: baroreceptor pressure buffer system
id: GO:0001978
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by baroreceptor feedback

regulation of systemic arterial blood pressure by chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by chemoreceptor signalling
has OBO namespace: biological_process
has related synonym: chemoreceptor control of blood pressure
id: GO:0001979
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by ischemic conditions
IAO_0000115: The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.
has exact synonym: ischemic regulation of systemic arterial blood pressure
has OBO namespace: biological_process
has related synonym: CNS ischemic response
has related synonym: ischemic control of blood pressure
id: GO:0001980
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure

baroreceptor detection of arterial stretch
IAO_0000115: The series of events by which the change in diameter of an artery is detected and converted to a molecular signal.
has OBO namespace: biological_process
id: GO:0001981
type: Class
subclass of: vascular process in circulatory system
subclass of: GO_0050982
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

baroreceptor response to decreased systemic arterial blood pressure
IAO_0000115: The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels.
has OBO namespace: biological_process
id: GO:0001982
type: Class
subclass of: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
subclass of: positive regulation of systemic arterial blood pressure

baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels.
has OBO namespace: biological_process
id: GO:0001983
type: Class
subclass of: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
subclass of: negative regulation of systemic arterial blood pressure

vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure.
has OBO namespace: biological_process
id: GO:0001984
type: Class
subclass of: GO_0042311
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to increased systemic arterial blood pressure

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.
has exact synonym: down regulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: down-regulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: downregulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: negative control of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: negative regulation of heart contraction rate in baroreceptor response to increased blood pressure
has narrow synonym: inhibition of heart contraction rate in baroreceptor response to increased blood pressure
has OBO namespace: biological_process
has related synonym: negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure
id: GO:0001985
type: Class
subclass of: GO_0010459
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to increased systemic arterial blood pressure

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.
has exact synonym: decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure
has exact synonym: decreased strength of cardiac contraction during baroreceptor response to increased blood pressure
has OBO namespace: biological_process
id: GO:0001986
type: Class
subclass of: GO_0045822
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to increased systemic arterial blood pressure

vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure.
has OBO namespace: biological_process
id: GO:0001987
type: Class
subclass of: GO_0042310
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to decreased systemic arterial blood pressure

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
IAO_0000115: Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.
has exact synonym: positive control of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: up regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: upregulation of heart contraction rate in baroreceptor response to decreased blood pressure
has narrow synonym: activation of heart contraction rate in baroreceptor response to decreased blood pressure
has narrow synonym: stimulation of heart contraction rate in baroreceptor response to decreased blood pressure
has OBO namespace: biological_process
has related synonym: positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure
id: GO:0001988
type: Class
subclass of: GO_0010460
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to decreased systemic arterial blood pressure

positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure.
has OBO namespace: biological_process
has related synonym: increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure
has related synonym: increased strength of cardiac contraction during baroreceptor response to decreased blood pressure
has related synonym: positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure
id: GO:0001989
type: Class
subclass of: GO_0045823
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to decreased systemic arterial blood pressure

regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: blood pressure regulation by hormone
has exact synonym: hormonal regulation of blood pressure
has OBO namespace: biological_process
has related synonym: hormonal control of blood pressure
id: GO:0001990
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: GO_0050886

regulation of systemic arterial blood pressure by circulatory renin-angiotensin
IAO_0000115: The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
has exact synonym: circulatory renin-angiotensin blood pressure regulation
has exact synonym: circulatory renin-angiotensin regulation of blood pressure
has OBO namespace: biological_process
has related synonym: circulatory renin-angiotensin control of blood pressure
has related synonym: control of blood pressure by circulatory renin-angiotensin
has related synonym: renin-angiotensin blood pressure control
id: GO:0001991
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin

regulation of systemic arterial blood pressure by vasopressin
IAO_0000115: The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.
has exact synonym: blood pressure regulation by vasopressin
has OBO namespace: biological_process
has related synonym: vasopressin control of blood pressure
id: GO:0001992
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

regulation of systemic arterial blood pressure by norepinephrine-epinephrine
IAO_0000115: The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system.
has exact synonym: norepinephrine-epinephrine blood pressure regulation
has OBO namespace: biological_process
has related synonym: noradrenaline-adrenaline regulation of blood pressure
has related synonym: norepinephrine-epinephrine blood pressure control
id: GO:0001993
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
IAO_0000115: A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.
has exact synonym: noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure
has exact synonym: norepinephrine-epinephrine vasoconstriction during blood pressure regulation
has OBO namespace: biological_process
has related synonym: norepinephrine-epinephrine vasoconstriction during blood pressure control
has related synonym: norepinephrine-epinephrine vasoconstriction during control of blood pressure
id: GO:0001994
type: Class
subclass of: GO_0042310
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of blood pressure by epinephrine-norepinephrine

norepinephrine-epinephrine catabolic process in blood stream
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream.
has exact synonym: noradrenaline-adrenalin catabolic process in blood stream
has OBO namespace: biological_process
id: GO:0001995
type: Class
subclass of: GO_0042419
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by norepinephrine-epinephrine

positive regulation of heart rate by epinephrine-norepinephrine
IAO_0000115: The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.
has exact synonym: positive regulation of cardiac contraction rate by epinephrine-norepinephrine
has exact synonym: positive regulation of heart contraction rate by adrenaline-noradrenaline
has exact synonym: up regulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: up-regulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: upregulation of heart contraction rate by epinephrine-norepinephrine
has narrow synonym: activation of heart contraction rate by epinephrine-norepinephrine
has narrow synonym: stimulation of heart contraction rate by epinephrine-norepinephrine
has OBO namespace: biological_process
has related synonym: increased chronotropy by epinephrine-norepinephrine
has related synonym: positive control of heart contraction rate by epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction rate by epinephrine-norepinephrine
id: GO:0001996
type: Class
subclass of: GO_0010460
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of blood pressure by epinephrine-norepinephrine

positive regulation of the force of heart contraction by epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.
has exact synonym: increased force of heart contraction by adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine
has exact synonym: increased strength of cardiac contraction by epinephrine-norepinephrine
has OBO namespace: biological_process
has related synonym: increased inotropy by epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by epinephrine-norepinephrine
id: GO:0001997
type: Class
subclass of: positive regulation of the force of heart contraction by chemical signal
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of blood pressure by epinephrine-norepinephrine

angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
IAO_0000115: The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.
has exact synonym: angiotensin mediated vasoconstriction during blood pressure regulation
has OBO namespace: biological_process
has related synonym: angiotensin mediated vasoconstriction during blood pressure control
has related synonym: angiotensin mediated vasoconstriction during control of blood pressure
id: GO:0001998
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: Restriction
  on property: part_of
  some values from: regulation of blood vessel size by renin-angiotensin

renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
IAO_0000115: The physiological response of the kidneys to a decrease in blood flow.
has OBO namespace: biological_process
has related synonym: renal response to blood flow during renin-angiotensin control of blood pressure
id: GO:0001999
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by circulatory renin-angiotensin

detection of renal blood flow
IAO_0000115: The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal.
has OBO namespace: biological_process
id: GO:0002000
type: Class
subclass of: GO_0050982
subclass of: Restriction
  on property: part_of
  some values from: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

renin secretion into blood stream
IAO_0000115: The regulated release of renin into the blood stream by juxtoglomerular cells.
has exact synonym: renin release into blood stream
has OBO namespace: biological_process
id: GO:0002001
type: Class
subclass of: GO_0009306
subclass of: Restriction
  on property: part_of
  some values from: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

regulation of angiotensin levels in blood
IAO_0000115: The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin.
has exact synonym: regulation of blood angiotensin level
has OBO namespace: biological_process
has related synonym: control of angiotensin levels in blood
has related synonym: control of blood angiotensin level
id: GO:0002002
type: Class
subclass of: GO_0010817
subclass of: GO_0060177
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by circulatory renin-angiotensin

angiotensin maturation
IAO_0000115: The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.
has OBO namespace: biological_process
id: GO:0002003
type: Class
subclass of: GO_0016486
subclass of: Restriction
  on property: part_of
  some values from: regulation of angiotensin levels in blood

secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
IAO_0000115: The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure.
has OBO namespace: biological_process
has related synonym: secretion of vasopressin during fast control of blood pressure
has related synonym: secretion of vasopressin during fast regulation of systemic arterial blood pressure
id: GO:0002004
type: Class
subclass of: GO_0030103
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by vasopressin

angiotensin catabolic process in blood
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood.
has OBO namespace: biological_process
id: GO:0002005
type: Class
subclass of: GO_0044254
subclass of: Restriction
  on property: part_of
  some values from: regulation of angiotensin levels in blood

vasoconstriction by vasopressin involved in systemic arterial blood pressure control
IAO_0000115: The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream.
has exact synonym: vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control
has OBO namespace: biological_process
id: GO:0002006
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by vasopressin

detection of hypoxic conditions in blood by chemoreceptor signaling
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of hypoxic conditions in blood by chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0002007
type: Class
subclass of: GO_0009593
subclass of: GO_0010850
subclass of: GO_0070887
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by chemoreceptor signaling

excitation of vasomotor center by chemoreceptor signaling
IAO_0000115: The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0002008
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by chemoreceptor signaling

morphogenesis of an epithelium
IAO_0000115: The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
has OBO namespace: biological_process
id: GO:0002009
type: Class
subclass of: GO_0048729
subclass of: Restriction
  on property: part_of
  some values from: GO_0060429

excitation of vasomotor center by baroreceptor signaling
IAO_0000115: The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure.
has exact synonym: excitation of vasomotor center by baroreceptor signalling
has OBO namespace: biological_process
id: GO:0002010
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to decreased systemic arterial blood pressure

morphogenesis of an epithelial sheet
IAO_0000115: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.
has OBO namespace: biological_process
id: GO:0002011
type: Class
subclass of: morphogenesis of an epithelium

vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has OBO namespace: biological_process
id: GO:0002012
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by chemoreceptor signaling

detection of carbon dioxide by vasomotor center
IAO_0000115: The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system.
has OBO namespace: biological_process
id: GO:0002013
type: Class
subclass of: detection of carbon dioxide
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by ischemic conditions

vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
IAO_0000115: The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.
has OBO namespace: biological_process
id: GO:0002014
type: Class
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by ischemic conditions

regulation of systemic arterial blood pressure by atrial baroreceptor feedback
IAO_0000115: A process that controls blood pressure by sensing the amount of stretch occurring in the atria.
has exact synonym: atrial baroreceptor regulation of systemic arterial blood pressure
has exact synonym: atrial low pressure baroreceptor regulation of blood pressure
has OBO namespace: biological_process
has related synonym: atrial control of blood pressure
has related synonym: atrial reflex
id: GO:0002015
type: Class
subclass of: heart process
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by baroreceptor feedback

regulation of blood volume by renin-angiotensin
IAO_0000115: The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.
has exact synonym: renin-angiotensin regulation of blood volume
has OBO namespace: biological_process
has related synonym: renin-angiotensin control of body fluid levels
id: GO:0002016
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin

regulation of blood volume by renal aldosterone
IAO_0000115: The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.
has exact synonym: aldosterone mediated regulation of blood volume
has exact synonym: renal regulation of blood volume by aldosterone
has OBO namespace: biological_process
has related synonym: aldosterone mediated control of body fluids
id: GO:0002017
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: regulation of systemic arterial blood pressure by hormone
subclass of: positive regulation of systemic arterial blood pressure

renin-angiotensin regulation of aldosterone production
IAO_0000115: The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
has OBO namespace: biological_process
has related synonym: renin-angiotensin control of aldosterone production
id: GO:0002018
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of blood volume by renin-angiotensin

regulation of renal output by angiotensin
IAO_0000115: The process in which angiotensin directly modulates the rate of urine output by the kidney.
has exact synonym: angiotensin mediated regulation of renal output
has exact synonym: angiotensin-mediated regulation of renal output
has OBO namespace: biological_process
has related synonym: angiotensin mediated control of renal output
id: GO:0002019
type: Class
subclass of: regulation of blood volume by renin-angiotensin

protease binding
IAO_0000115: Interacting selectively and non-covalently with any protease or peptidase.
has OBO namespace: molecular_function
id: GO:0002020
type: Class
subclass of: GO_0019899

response to dietary excess
IAO_0000115: The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
has OBO namespace: biological_process
id: GO:0002021
type: Class
subclass of: GO_0044707
subclass of: GO_0050896
subclass of: Restriction
  on property: part_of
  some values from: GO_0040014

detection of dietary excess
IAO_0000115: The neurological process in which the brain senses excessive caloric intake.
has OBO namespace: biological_process
id: GO:0002022
type: Class
subclass of: GO_0050877
subclass of: Restriction
  on property: part_of
  some values from: response to dietary excess

reduction of food intake in response to dietary excess
IAO_0000115: The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food.
has OBO namespace: biological_process
id: GO:0002023
type: Class
subclass of: GO_0042755
subclass of: Restriction
  on property: part_of
  some values from: response to dietary excess

diet induced thermogenesis
IAO_0000115: The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
has OBO namespace: biological_process
id: GO:0002024
type: Class
subclass of: GO_0044253
subclass of: Restriction
  on property: part_of
  some values from: response to dietary excess

vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
IAO_0000115: A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.
has exact synonym: noradrenaline-adrenaline vasodilation involved in regulation of blood pressure
has exact synonym: norepinephrine-epinephrine vasodilation during blood pressure regulation
has OBO namespace: biological_process
id: GO:0002025
type: Class
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by norepinephrine-epinephrine

regulation of the force of heart contraction
IAO_0000115: Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
has exact synonym: cardiac inotropy
has exact synonym: heart inotropy
has OBO namespace: biological_process
id: GO:0002026
type: Class
subclass of: GO_0008016
subclass of: GO_0065008

regulation of heart rate
IAO_0000115: Any process that modulates the frequency or rate of heart contraction.
has exact synonym: cardiac chronotropy
has exact synonym: regulation of heart contraction rate
has exact synonym: regulation of rate of heart contraction
has OBO namespace: biological_process
id: GO:0002027
type: Class
subclass of: GO_0008016
subclass of: GO_0065008

regulation of sodium ion transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: regulation of Na+ transport
has exact synonym: regulation of sodium transport
has OBO namespace: biological_process
id: GO:0002028
type: Class
subclass of: GO_0010959
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006814

desensitization of G-protein coupled receptor protein signaling pathway
IAO_0000115: The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway.
has exact synonym: desensitisation of G-protein coupled receptor protein signalling pathway
has OBO namespace: biological_process
id: GO:0002029
type: Class
subclass of: GO_0022401
subclass of: GO_0045744

inhibitory G-protein coupled receptor phosphorylation
IAO_0000115: The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site.
has OBO namespace: biological_process
id: GO:0002030
type: Class
subclass of: GO_0006468
subclass of: Restriction
  on property: part_of
  some values from: desensitization of G-protein coupled receptor protein signaling pathway

G-protein coupled receptor internalization
IAO_0000115: The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle.
has OBO namespace: biological_process
id: GO:0002031
type: Class
subclass of: GO_0031623
subclass of: Restriction
  on property: part_of
  some values from: desensitization of G-protein coupled receptor protein signaling pathway

desensitization of G-protein coupled receptor protein signaling pathway by arrestin
IAO_0000115: The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.
has exact synonym: arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway
has exact synonym: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway
has exact synonym: arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway
has OBO namespace: biological_process
id: GO:0002032
type: Class
subclass of: desensitization of G-protein coupled receptor protein signaling pathway
subclass of: GO_0032091

vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
IAO_0000115: The process that increases the size of a blood vessel via the renin-angiotensin system.
has OBO namespace: biological_process
id: GO:0002033
type: Class
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311
subclass of: Restriction
  on property: part_of
  some values from: regulation of blood vessel size by renin-angiotensin

regulation of blood vessel size by renin-angiotensin
IAO_0000115: The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.
has exact synonym: renin-angiotensin regulation of blood vessel size
has OBO namespace: biological_process
id: GO:0002034
type: Class
subclass of: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin
subclass of: GO_0050880

brain renin-angiotensin system
IAO_0000115: The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.
has OBO namespace: biological_process
id: GO:0002035
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: regulation of blood volume by renin-angiotensin

regulation of L-glutamate transport
IAO_0000115: Any process that modulates the frequency, rate or extent of L-glutamate transport.
has OBO namespace: biological_process
id: GO:0002036
type: Class
subclass of: GO_0051955
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0015813

negative regulation of L-glutamate transport
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport.
has exact synonym: down regulation of L-glutamate transport
has exact synonym: down-regulation of L-glutamate transport
has exact synonym: downregulation of L-glutamate transport
has narrow synonym: inhibition of L-glutamate transport
has OBO namespace: biological_process
id: GO:0002037
type: Class
subclass of: regulation of L-glutamate transport
subclass of: GO_0051956
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0015813

positive regulation of L-glutamate transport
IAO_0000115: Any process that activates or increases the frequency, rate or extent of L-glutamate transport.
has exact synonym: up regulation of L-glutamate transport
has exact synonym: up-regulation of L-glutamate transport
has exact synonym: upregulation of L-glutamate transport
has narrow synonym: activation of L-glutamate transport
has narrow synonym: stimulation of L-glutamate transport
has OBO namespace: biological_process
id: GO:0002038
type: Class
subclass of: regulation of L-glutamate transport
subclass of: GO_0051957
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0015813

p53 binding
IAO_0000115: Interacting selectively and non-covalently with one of the p53 family of proteins.
has OBO namespace: molecular_function
id: GO:0002039
type: Class
subclass of: GO_0005515

sprouting angiogenesis
IAO_0000115: The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.
has OBO namespace: biological_process
id: GO:0002040
type: Class
subclass of: angiogenesis

intussusceptive angiogenesis
IAO_0000115: The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.
has OBO namespace: biological_process
id: GO:0002041
type: Class
subclass of: angiogenesis

cell migration involved in sprouting angiogenesis
IAO_0000115: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
has OBO namespace: biological_process
id: GO:0002042
type: Class
subclass of: GO_0043534
subclass of: Restriction
  on property: part_of
  some values from: sprouting angiogenesis

blood vessel endothelial cell proliferation involved in sprouting angiogenesis
IAO_0000115: The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
has OBO namespace: biological_process
has related synonym: blood vessel endothelial cell proliferation during sprouting angiogenesis
id: GO:0002043
type: Class
subclass of: endothelial cell proliferation
subclass of: Restriction
  on property: part_of
  some values from: sprouting angiogenesis

blood vessel endothelial cell migration involved in intussusceptive angiogenesis
IAO_0000115: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis.
has OBO namespace: biological_process
id: GO:0002044
type: Class
subclass of: GO_0043534
subclass of: Restriction
  on property: part_of
  some values from: intussusceptive angiogenesis

regulation of cell adhesion involved in intussusceptive angiogenesis
IAO_0000115: The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis.
has OBO namespace: biological_process
id: GO:0002045
type: Class
subclass of: GO_0030155
subclass of: Restriction
  on property: part_of
  some values from: intussusceptive angiogenesis

opsin binding
IAO_0000115: Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.
has alternative id: GO:0016030
has narrow synonym: metarhodopsin binding
has OBO namespace: molecular_function
id: GO:0002046
type: Class
subclass of: GO_0005515

phenazine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
has OBO namespace: biological_process
has related synonym: acridizine biosynthesis
has related synonym: acridizine biosynthetic process
has related synonym: azophenylene biosynthesis
has related synonym: azophenylene biosynthetic process
has related synonym: dibenzo-p-diazine biosynthesis
has related synonym: dibenzo-p-diazine biosynthetic process
has related synonym: dibenzopyrazine biosynthesis
has related synonym: dibenzopyrazine biosynthetic process
id: GO:0002047
in subset: gosubset prok
type: Class
subclass of: GO_0017000
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_0044271
subclass of: GO_1901362
subclass of: GO_1901566

pyoverdine metabolic process
IAO_0000115: The chemical reactions and pathways involving the siderochrome pyoverdine.
has exact synonym: pyoverdine metabolism
has OBO namespace: biological_process
id: GO:0002048
type: Class
subclass of: GO_0009237

pyoverdine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
has OBO namespace: biological_process
id: GO:0002049
type: Class
subclass of: pyoverdine metabolic process
subclass of: GO_0019290

pyoverdine catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine.
has OBO namespace: biological_process
id: GO:0002050
type: Class
subclass of: pyoverdine metabolic process
subclass of: GO_0046215

osteoblast fate commitment
IAO_0000115: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
has OBO namespace: biological_process
id: GO:0002051
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: osteoblast differentiation

positive regulation of neuroblast proliferation
IAO_0000115: Any process that activates or increases the rate of neuroblast proliferation.
has exact synonym: up regulation of neuroblast proliferation
has exact synonym: up-regulation of neuroblast proliferation
has exact synonym: upregulation of neuroblast proliferation
has narrow synonym: activation of neuroblast proliferation
has narrow synonym: stimulation of neuroblast proliferation
has OBO namespace: biological_process
id: GO:0002052
type: Class
subclass of: GO_0050769
subclass of: GO_2000179
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0007405

positive regulation of mesenchymal cell proliferation
IAO_0000115: The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
has exact synonym: up regulation of mesenchymal cell proliferation
has exact synonym: up-regulation of mesenchymal cell proliferation
has exact synonym: upregulation of mesenchymal cell proliferation
has narrow synonym: activation of mesenchymal cell proliferation
has narrow synonym: stimulation of mesenchymal cell proliferation
has OBO namespace: biological_process
id: GO:0002053
type: Class
subclass of: GO_0008284
subclass of: GO_0010464
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0010463

nucleobase binding
IAO_0000115: Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.
has OBO namespace: molecular_function
id: GO:0002054
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0036094
subclass of: GO_0097159
subclass of: GO_1901363

adenine binding
IAO_0000115: Interacting selectively and non-covalently with adenine, a purine base.
has exact synonym: 6-aminopurine binding
has OBO namespace: molecular_function
id: GO:0002055
type: Class
subclass of: purine nucleobase binding

cytosine binding
IAO_0000115: Interacting selectively and non-covalently with cytosine.
has OBO namespace: molecular_function
id: GO:0002056
type: Class
subclass of: pyrimidine nucleobase binding

guanine binding
IAO_0000115: Interacting selectively and non-covalently with guanine.
has OBO namespace: molecular_function
id: GO:0002057
type: Class
subclass of: purine nucleobase binding

uracil binding
IAO_0000115: Interacting selectively and non-covalently with uracil.
has OBO namespace: molecular_function
id: GO:0002058
type: Class
subclass of: pyrimidine nucleobase binding

thymine binding
IAO_0000115: Interacting selectively and non-covalently with thymine.
has OBO namespace: molecular_function
id: GO:0002059
type: Class
subclass of: pyrimidine nucleobase binding

purine nucleobase binding
IAO_0000115: Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.
has exact synonym: purine base binding
has OBO namespace: molecular_function
has related synonym: purine binding
id: GO:0002060
type: Class
subclass of: nucleobase binding

pyrimidine nucleobase binding
IAO_0000115: Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton.
has exact synonym: pyrimidine base binding
has narrow synonym: 1,3-diazine binding
has OBO namespace: molecular_function
has related synonym: pyrimidine binding
id: GO:0002061
type: Class
subclass of: nucleobase binding

chondrocyte differentiation
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
has OBO namespace: biological_process
id: GO:0002062
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0051216

chondrocyte development
IAO_0000115: The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
has OBO namespace: biological_process
id: GO:0002063
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: chondrocyte differentiation

epithelial cell development
IAO_0000115: The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
has OBO namespace: biological_process
id: GO:0002064
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: GO_0030855

columnar/cuboidal epithelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
has OBO namespace: biological_process
id: GO:0002065
type: Class
subclass of: GO_0030855

columnar/cuboidal epithelial cell development
IAO_0000115: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
has OBO namespace: biological_process
id: GO:0002066
type: Class
subclass of: epithelial cell development
subclass of: Restriction
  on property: part_of
  some values from: columnar/cuboidal epithelial cell differentiation

glandular epithelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
has OBO namespace: biological_process
id: GO:0002067
type: Class
subclass of: columnar/cuboidal epithelial cell differentiation

glandular epithelial cell development
IAO_0000115: The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
has OBO namespace: biological_process
id: GO:0002068
type: Class
subclass of: columnar/cuboidal epithelial cell development
subclass of: Restriction
  on property: part_of
  some values from: glandular epithelial cell differentiation

columnar/cuboidal epithelial cell maturation
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
has OBO namespace: biological_process
id: GO:0002069
type: Class
subclass of: epithelial cell maturation
subclass of: Restriction
  on property: part_of
  some values from: columnar/cuboidal epithelial cell development

epithelial cell maturation
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
has OBO namespace: biological_process
id: GO:0002070
type: Class
subclass of: GO_0048469
subclass of: Restriction
  on property: part_of
  some values from: epithelial cell development

glandular epithelial cell maturation
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
has OBO namespace: biological_process
id: GO:0002071
type: Class
subclass of: columnar/cuboidal epithelial cell maturation
subclass of: Restriction
  on property: part_of
  some values from: glandular epithelial cell development

optic cup morphogenesis involved in camera-type eye development
IAO_0000115: The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.
has exact synonym: optic cup morphogenesis involved in camera-style eye development
has OBO namespace: biological_process
id: GO:0002072
type: Class
subclass of: GO_0016331
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0060900

extraocular skeletal muscle development
IAO_0000115: The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.
has OBO namespace: biological_process
id: GO:0002074
type: Class
subclass of: GO_0007519
subclass of: Restriction
  on property: part_of
  some values from: GO_0043010

somitomeric trunk muscle development
IAO_0000115: The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.
has OBO namespace: biological_process
id: GO:0002075
type: Class
subclass of: GO_0007519

osteoblast development
IAO_0000115: The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
has OBO namespace: biological_process
id: GO:0002076
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: osteoblast differentiation

acrosome matrix dispersal
IAO_0000115: The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg.
has OBO namespace: biological_process
id: GO:0002077
type: Class
subclass of: GO_0048610
subclass of: GO_0051603
subclass of: Restriction
  on property: part_of
  some values from: GO_0007340

membrane fusion involved in acrosome reaction
IAO_0000115: The fusion of the plasma membrane of the sperm with the outer acrosomal membrane.
has exact synonym: membrane fusion involved in the acrosomal reaction
has OBO namespace: biological_process
id: GO:0002078
type: Class
subclass of: GO_0006944
subclass of: GO_0022412
subclass of: Restriction
  on property: part_of
  some values from: GO_0007340

inner acrosomal membrane
IAO_0000115: The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.
has OBO namespace: cellular_component
id: GO:0002079
type: Class
comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
subclass of: GO_0044425
subclass of: GO_0044433
subclass of: Restriction
  on property: part_of
  some values from: acrosomal membrane

acrosomal membrane
IAO_0000115: The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.
has OBO namespace: cellular_component
id: GO:0002080
type: Class
subclass of: GO_0030667
subclass of: Restriction
  on property: part_of
  some values from: acrosomal vesicle

outer acrosomal membrane
IAO_0000115: The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.
has OBO namespace: cellular_component
id: GO:0002081
type: Class
comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
subclass of: GO_0044425
subclass of: GO_0044433
subclass of: Restriction
  on property: part_of
  some values from: acrosomal membrane

regulation of oxidative phosphorylation
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
has OBO namespace: biological_process
id: GO:0002082
type: Class
subclass of: GO_0042325
subclass of: GO_0043467
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006119

4-hydroxybenzoate decaprenyltransferase activity
IAO_0000115: Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.
has db xref: EC:2.5.1.39
has db xref: MetaCyc:RXN-9230
has OBO namespace: molecular_function
id: GO:0002083
type: Class
subclass of: polyprenyltransferase activity

protein depalmitoylation
IAO_0000115: The removal of palymitoyl groups from a lipoprotein.
has OBO namespace: biological_process
id: GO:0002084
type: Class
subclass of: GO_0035601
subclass of: GO_0042159

inhibition of neuroepithelial cell differentiation
IAO_0000115: Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.
has narrow synonym: negative regulation of neural plate formation
has narrow synonym: repression of premature neural plate formation
has OBO namespace: biological_process
id: GO:0002085
type: Class
subclass of: GO_0022603
subclass of: GO_0045596
subclass of: GO_0045995
subclass of: GO_0048505
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0060563

diaphragm contraction
IAO_0000115: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.
has OBO namespace: biological_process
id: GO:0002086
type: Class
subclass of: involuntary skeletal muscle contraction
subclass of: respiratory system process

regulation of respiratory gaseous exchange by neurological system process
IAO_0000115: A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
has exact synonym: neurological control of breathing
has OBO namespace: biological_process
id: GO:0002087
type: Class
subclass of: GO_0044065
subclass of: GO_0050877

lens development in camera-type eye
IAO_0000115: The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
has exact synonym: lens development
has exact synonym: lens development in camera-style eye
has OBO namespace: biological_process
id: GO:0002088
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0043010

lens morphogenesis in camera-type eye
IAO_0000115: The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
has exact synonym: lens morphogenesis
has exact synonym: lens morphogenesis in camera-style eye
has OBO namespace: biological_process
id: GO:0002089
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0048593
subclass of: Restriction
  on property: part_of
  some values from: lens development in camera-type eye

regulation of receptor internalization
IAO_0000115: Any process that modulates the frequency, rate or extent of receptor internalization.
has OBO namespace: biological_process
id: GO:0002090
type: Class
subclass of: GO_0031323
subclass of: GO_0048259
subclass of: GO_0060255
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0031623

negative regulation of receptor internalization
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
has exact synonym: down regulation of receptor internalization
has exact synonym: down-regulation of receptor internalization
has exact synonym: downregulation of receptor internalization
has narrow synonym: inhibition of receptor internalization
has OBO namespace: biological_process
id: GO:0002091
type: Class
subclass of: regulation of receptor internalization
subclass of: GO_0010605
subclass of: GO_0031324
subclass of: GO_0048261
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0031623

positive regulation of receptor internalization
IAO_0000115: Any process that activates or increases the frequency, rate or extent of receptor internalization.
has exact synonym: up regulation of receptor internalization
has exact synonym: up-regulation of receptor internalization
has exact synonym: upregulation of receptor internalization
has narrow synonym: activation of receptor internalization
has narrow synonym: stimulation of receptor internalization
has OBO namespace: biological_process
id: GO:0002092
type: Class
subclass of: regulation of receptor internalization
subclass of: GO_0010604
subclass of: GO_0031325
subclass of: GO_0048260
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0031623

auditory receptor cell morphogenesis
IAO_0000115: Any process that alters the size or shape of an auditory receptor cell.
has broad synonym: hair cell morphogenesis
has OBO namespace: biological_process
id: GO:0002093
type: Class
subclass of: GO_0048598
subclass of: GO_0048646
subclass of: GO_0048667
subclass of: Restriction
  on property: part_of
  some values from: GO_0060117
subclass of: Restriction
  on property: part_of
  some values from: GO_0042472

polyprenyltransferase activity
IAO_0000115: Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).
has OBO namespace: molecular_function
id: GO:0002094
in subset: gosubset prok
type: Class
subclass of: GO_0004659

caveolar macromolecular signaling complex
IAO_0000115: A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
has exact synonym: caveolar macromolecular signalling complex
has OBO namespace: cellular_component
id: GO:0002095
type: Class
subclass of: GO_0043234
subclass of: GO_0044459
subclass of: Restriction
  on property: part_of
  some values from: GO_0005901

polkadots
IAO_0000115: A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.
has OBO namespace: cellular_component
id: GO:0002096
type: Class
comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.
subclass of: GO_0043234
subclass of: GO_0044444

tRNA wobble base modification
IAO_0000115: The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.
has OBO namespace: biological_process
id: GO:0002097
type: Class
subclass of: GO_0006400

tRNA wobble uridine modification
IAO_0000115: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.
has OBO namespace: biological_process
id: GO:0002098
type: Class
subclass of: tRNA wobble base modification

tRNA wobble guanine modification
IAO_0000115: The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified.
has OBO namespace: biological_process
id: GO:0002099
type: Class
subclass of: tRNA wobble base modification

tRNA wobble adenosine to inosine editing
IAO_0000115: The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.
has OBO namespace: biological_process
id: GO:0002100
type: Class
subclass of: tRNA wobble base modification

tRNA wobble cytosine modification
IAO_0000115: The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.
has OBO namespace: biological_process
id: GO:0002101
type: Class
subclass of: tRNA wobble base modification

podosome
IAO_0000115: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
has db xref: Wikipedia:Podosome
has OBO namespace: cellular_component
id: GO:0002102
type: Class
comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
subclass of: GO_0043232
subclass of: GO_0043234
subclass of: GO_0044430
subclass of: Restriction
  on property: part_of
  some values from: GO_0015629

endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0002103
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0002104
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0002105
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
has OBO namespace: biological_process
id: GO:0002106
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
IAO_0000115: The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end.
has OBO namespace: biological_process
id: GO:0002107
type: Class
subclass of: maturation of 5S rRNA
subclass of: GO_0031125

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0002108
type: Class
subclass of: maturation of LSU-rRNA

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.
has OBO namespace: biological_process
id: GO:0002109
type: Class
subclass of: GO_0030490

cotranscriptional mitochondrial rRNA nucleotide insertion
IAO_0000115: The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis.
has OBO namespace: biological_process
id: GO:0002110
type: Class
subclass of: rRNA modification
subclass of: GO_0070705

BRCA2-BRAF35 complex
IAO_0000115: A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.
has OBO namespace: cellular_component
id: GO:0002111
type: Class
subclass of: GO_0043234
subclass of: GO_0044428

interleukin-33 receptor binding
IAO_0000115: Interacting selectively and non-covalently with the interleukin-33 receptor.
has narrow synonym: IL-33
has narrow synonym: interleukin-33 receptor ligand
has OBO namespace: molecular_function
id: GO:0002112
type: Class
subclass of: GO_0005126

interleukin-33 binding
IAO_0000115: Interacting selectively and non-covalently with interleukin-33.
has exact synonym: IL-33 binding
has OBO namespace: molecular_function
id: GO:0002113
type: Class
subclass of: GO_0019955

interleukin-33 receptor activity
IAO_0000115: Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: IL-33 receptor activity
has exact synonym: IL-33R
has OBO namespace: molecular_function
id: GO:0002114
type: Class
subclass of: GO_0004896

store-operated calcium entry
IAO_0000115: A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
has broad synonym: calcium ion import
has exact synonym: SOCE
has exact synonym: capacitative calcium entry
has exact synonym: store-operated calcium import
has OBO namespace: biological_process
id: GO:0002115
type: Class
comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
subclass of: GO_0006816

semaphorin receptor complex
IAO_0000115: A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
has exact synonym: plexin-neurophilin complex
has OBO namespace: cellular_component
id: GO:0002116
type: Class
subclass of: GO_0043235

amphibian larval development
IAO_0000115: The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form.
has OBO namespace: biological_process
id: GO:0002117
type: Class
subclass of: larval development

aggressive behavior
IAO_0000115: A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.
has db xref: Wikipedia:Aggression
has exact synonym: aggression
has OBO namespace: biological_process
id: GO:0002118
type: Class
subclass of: GO_0051705

nematode larval development
IAO_0000115: The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
has OBO namespace: biological_process
id: GO:0002119
type: Class
subclass of: larval development

predatory behavior
IAO_0000115: Aggressive behavior involving attack on prey by a predator.
has exact synonym: predatory aggression
has exact synonym: predatory aggressive behavior
has OBO namespace: biological_process
id: GO:0002120
type: Class
subclass of: aggressive behavior
subclass of: GO_0044366

inter-male aggressive behavior
IAO_0000115: Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
has exact synonym: inter-male aggression
has OBO namespace: biological_process
id: GO:0002121
type: Class
subclass of: aggressive behavior

fear-induced aggressive behavior
IAO_0000115: Aggressive behavior associated with attempts to flee from a threat.
has exact synonym: fear-induced aggression
has OBO namespace: biological_process
id: GO:0002122
type: Class
subclass of: aggressive behavior

irritable aggressive behavior
IAO_0000115: Aggressive behavior induced by frustration and directed against an available target.
has exact synonym: irritable aggression
has OBO namespace: biological_process
id: GO:0002123
type: Class
subclass of: aggressive behavior

territorial aggressive behavior
IAO_0000115: Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.
has exact synonym: territorial aggression
has OBO namespace: biological_process
id: GO:0002124
type: Class
subclass of: aggressive behavior

maternal aggressive behavior
IAO_0000115: Aggressive behavior of a female to protect her offspring from a threat.
has exact synonym: maternal aggression
has OBO namespace: biological_process
id: GO:0002125
type: Class
comment: Paternal aggression also exists. Serves to protect the offspring from intruders.
subclass of: aggressive behavior

instrumental aggressive behavior
IAO_0000115: Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation.
has exact synonym: instrumental aggression
has OBO namespace: biological_process
id: GO:0002126
type: Class
subclass of: aggressive behavior

wobble base cytosine methylation
IAO_0000115: The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.
has exact synonym: wobble position m5C biosynthesis
has OBO namespace: biological_process
id: GO:0002127
type: Class
subclass of: tRNA wobble cytosine modification
subclass of: tRNA C5-cytosine methylation

tRNA nucleoside ribose methylation
IAO_0000115: The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position.
has OBO namespace: biological_process
id: GO:0002128
type: Class
subclass of: GO_0030488

wobble position guanine ribose methylation
IAO_0000115: The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
has OBO namespace: biological_process
id: GO:0002129
type: Class
subclass of: wobble position ribose methylation
subclass of: tRNA guanine ribose methylation

wobble position ribose methylation
IAO_0000115: The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position.
has OBO namespace: biological_process
id: GO:0002130
type: Class
subclass of: tRNA nucleoside ribose methylation

wobble position cytosine ribose methylation
IAO_0000115: The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
has OBO namespace: biological_process
id: GO:0002131
type: Class
subclass of: wobble position ribose methylation

wobble position uridine ribose methylation
IAO_0000115: The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
has OBO namespace: biological_process
id: GO:0002132
type: Class
subclass of: wobble position ribose methylation

polycystin complex
IAO_0000115: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.
has OBO namespace: cellular_component
id: GO:0002133
type: Class
comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
subclass of: GO_0043234

UTP binding
IAO_0000115: Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate.
has OBO namespace: molecular_function
id: GO:0002134
type: Class
subclass of: GO_0032551
subclass of: GO_0032557
subclass of: GO_0043168

CTP binding
IAO_0000115: Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate.
has OBO namespace: molecular_function
id: GO:0002135
type: Class
subclass of: GO_0032551
subclass of: GO_0032557
subclass of: GO_0043168

wobble base lysidine biosynthesis
IAO_0000115: The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.
has OBO namespace: biological_process
id: GO:0002136
type: Class
comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP.
subclass of: tRNA wobble cytosine modification

nuclear cluster
IAO_0000115: Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1).
has OBO namespace: cellular_component
id: GO:0002137
type: Class
subclass of: GO_0044454
subclass of: Restriction
  on property: part_of
  some values from: GO_0031618

retinoic acid biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
has exact synonym: retinoic acid anabolic process
has OBO namespace: biological_process
id: GO:0002138
type: Class
subclass of: GO_0016102
subclass of: GO_0042573
subclass of: GO_0072330

stereocilia coupling link
IAO_0000115: A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.
has OBO namespace: cellular_component
id: GO:0002139
type: Class
subclass of: GO_0044464

stereocilia tip link
IAO_0000115: A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia.
has OBO namespace: cellular_component
id: GO:0002140
type: Class
subclass of: stereocilia coupling link

stereocilia ankle link
IAO_0000115: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.
has OBO namespace: cellular_component
id: GO:0002141
type: Class
subclass of: stereocilia coupling link

stereocilia ankle link complex
IAO_0000115: A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.
has OBO namespace: cellular_component
id: GO:0002142
type: Class
subclass of: GO_0043234
subclass of: GO_0044464
subclass of: Restriction
  on property: part_of
  some values from: stereocilia ankle link

tRNA wobble position uridine thiolation
IAO_0000115: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
has exact synonym: tRNA wobble uridine thiolation
has exact synonym: wobble position s2U biosynthesis
has OBO namespace: biological_process
id: GO:0002143
type: Class
comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
subclass of: tRNA wobble uridine modification
subclass of: GO_0034227

cytosolic tRNA wobble base thiouridylase complex
IAO_0000115: A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes.
has broad synonym: tRNA thiouridylase
has narrow synonym: Cut1-Cut2 complex
has OBO namespace: cellular_component
id: GO:0002144
type: Class
subclass of: GO_0043234
subclass of: GO_0044445

4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
IAO_0000115: Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+).
has db xref: MetaCyc:RXN0-3543
has exact synonym: HMP-PP diphosphatase
has exact synonym: HMP-PP pyrophosphatase
has OBO namespace: molecular_function
id: GO:0002145
type: Class
subclass of: GO_0016462

steroid hormone receptor import into nucleus
IAO_0000115: The directed movement of a steroid hormone receptor into the nucleus.
has narrow synonym: steroid hormone receptor nuclear translocation
has OBO namespace: biological_process
id: GO:0002146
type: Class
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
subclass of: GO_0006606

glucocorticoid receptor import into nucleus
IAO_0000115: The directed movement of a glucocorticoid receptor into the nucleus.
has narrow synonym: glucocorticoid receptor nuclear translocation
has OBO namespace: biological_process
id: GO:0002147
type: Class
subclass of: steroid hormone receptor import into nucleus
subclass of: Restriction
  on property: part_of
  some values from: GO_0042921

hypochlorous acid metabolic process
IAO_0000115: The chemical reactions and pathways involving hypochlorous acid.
has exact synonym: HClO metabolic process
has exact synonym: HOCl metabolic process
has exact synonym: hypochlorous acid metabolism
has OBO namespace: biological_process
has related synonym: hypochlorite metabolic process
id: GO:0002148
type: Class
subclass of: GO_0043436
subclass of: GO_0072593

hypochlorous acid biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of hypochlorous acid.
has exact synonym: HClO biosynthetic process
has exact synonym: HOCl biosynthetic process
has exact synonym: hypochlorous acid biosynthesis
has OBO namespace: biological_process
has related synonym: hypochlorite biosynthetic process
id: GO:0002149
type: Class
comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils.
subclass of: hypochlorous acid metabolic process
subclass of: GO_0044283

hypochlorous acid catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of hypochlorous acid.
has exact synonym: HClO catabolic process
has exact synonym: HOCl catabolic process
has exact synonym: hypochlorous acid catabolism
has OBO namespace: biological_process
has related synonym: hypochlorite catabolic process
id: GO:0002150
type: Class
subclass of: hypochlorous acid metabolic process
subclass of: GO_0044282

G-quadruplex RNA binding
IAO_0000115: Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
has broad synonym: G quartet binding
has broad synonym: G-quartet binding
has exact synonym: G quadruplex binding
has exact synonym: G quartet RNA binding
has OBO namespace: molecular_function
id: GO:0002151
type: Class
comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure.
subclass of: RNA binding

bile acid conjugation
IAO_0000115: The process in which bile acids are covalently linked to taurine or glycine.
has OBO namespace: biological_process
id: GO:0002152
type: Class
comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine).
subclass of: GO_0008206

steroid receptor RNA activator RNA binding
IAO_0000115: Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
has exact synonym: SRA binding
has OBO namespace: molecular_function
id: GO:0002153
type: Class
comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken).
subclass of: single-stranded RNA binding

thyroid hormone mediated signaling pathway
IAO_0000115: A series of molecular signals mediated by the detection of a thyroid hormone.
has exact synonym: thyroid hormone mediated signalling pathway
has OBO namespace: biological_process
id: GO:0002154
type: Class
subclass of: GO_0009755
subclass of: GO_0030522

regulation of thyroid hormone mediated signaling pathway
IAO_0000115: Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
has exact synonym: regulation of thyroid hormone mediated signalling pathway
has OBO namespace: biological_process
id: GO:0002155
type: Class
subclass of: GO_0009966
subclass of: Restriction
  on property: RO_0002211
  some values from: thyroid hormone mediated signaling pathway

negative regulation of thyroid hormone mediated signaling pathway
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway.
has exact synonym: negative regulation of thyroid hormone mediated signalling pathway
has OBO namespace: biological_process
id: GO:0002156
type: Class
subclass of: regulation of thyroid hormone mediated signaling pathway
subclass of: GO_0009968
subclass of: Restriction
  on property: RO_0002212
  some values from: thyroid hormone mediated signaling pathway

positive regulation of thyroid hormone mediated signaling pathway
IAO_0000115: Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway.
has exact synonym: positive regulation of thyroid hormone mediated signalling pathway
has OBO namespace: biological_process
id: GO:0002157
type: Class
subclass of: regulation of thyroid hormone mediated signaling pathway
subclass of: GO_0009967
subclass of: Restriction
  on property: RO_0002213
  some values from: thyroid hormone mediated signaling pathway

osteoclast proliferation
IAO_0000115: The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.
has OBO namespace: biological_process
id: GO:0002158
type: Class
subclass of: GO_0070661

desmosome assembly
IAO_0000115: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
has OBO namespace: biological_process
id: GO:0002159
type: Class
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
subclass of: desmosome organization
subclass of: GO_0007043

desmosome maintenance
IAO_0000115: The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
has OBO namespace: biological_process
id: GO:0002160
type: Class
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
subclass of: desmosome organization
subclass of: GO_0045217

aminoacyl-tRNA editing activity
IAO_0000115: The hydrolysis of an incorrectly aminoacylated tRNA.
has OBO namespace: molecular_function
has related synonym: amino acid proofreading activity
has related synonym: aminoacyl-tRNA hydrolysis activity
id: GO:0002161
type: Class
subclass of: GO_0052689

dystroglycan binding
IAO_0000115: Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
has alternative id: GO:0002163
has alternative id: GO:0002166
has narrow synonym: alpha-dystroglycan binding
has narrow synonym: beta-dystroglycan binding
has OBO namespace: molecular_function
id: GO:0002162
type: Class
subclass of: glycoprotein binding

larval development
IAO_0000115: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.
has OBO namespace: biological_process
id: GO:0002164
type: Class
subclass of: GO_0009791

instar larval or pupal development
IAO_0000115: The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.
has OBO namespace: biological_process
id: GO:0002165
type: Class
subclass of: GO_0009791

VRK3/VHR/ERK complex
IAO_0000115: A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.
has OBO namespace: cellular_component
id: GO:0002167
type: Class
subclass of: GO_0043234

instar larval development
IAO_0000115: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
has OBO namespace: biological_process
id: GO:0002168
type: Class
subclass of: larval development
subclass of: instar larval or pupal development

3-methylcrotonyl-CoA carboxylase complex, mitochondrial
IAO_0000115: A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
has OBO namespace: cellular_component
id: GO:0002169
type: Class
subclass of: GO_0043234
subclass of: GO_0044429

high affinity IgA receptor activity
IAO_0000115: Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0002170
type: Class
subclass of: GO_0019766

low affinity IgA receptor activity
IAO_0000115: Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0002171
type: Class
subclass of: GO_0019766

high affinity IgM receptor activity
IAO_0000115: Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0002172
type: Class
subclass of: IgM receptor activity

low affinity IgM receptor activity
IAO_0000115: Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has OBO namespace: molecular_function
id: GO:0002173
type: Class
subclass of: IgM receptor activity

mammary stem cell proliferation
IAO_0000115: The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ.
has OBO namespace: biological_process
id: GO:0002174
type: Class
subclass of: GO_0008283
subclass of: Restriction
  on property: part_of
  some values from: GO_0030879

protein localization to paranode region of axon
IAO_0000115: A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.
has exact synonym: protein localisation to paranode region of axon
has OBO namespace: biological_process
id: GO:0002175
type: Class
subclass of: GO_0034613

male germ cell proliferation
IAO_0000115: The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.
has OBO namespace: biological_process
id: GO:0002176
type: Class
subclass of: GO_0036093

manchette
IAO_0000115: A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation.
has OBO namespace: cellular_component
id: GO:0002177
type: Class
subclass of: GO_0044430
subclass of: Restriction
  on property: part_of
  some values from: GO_0015630

palmitoyltransferase complex
IAO_0000115: A protein complex with palmitoyltransferase activity.
has OBO namespace: cellular_component
id: GO:0002178
type: Class
subclass of: GO_0043234

homodimeric serine palmitoyltransferase complex
IAO_0000115: A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.
has OBO namespace: cellular_component
id: GO:0002179
type: Class
comment: This complex occurs primarily in bacteria.
subclass of: palmitoyltransferase complex

5-lipoxygenase complex
IAO_0000115: An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.
has OBO namespace: cellular_component
id: GO:0002180
type: Class
subclass of: GO_0043234
subclass of: GO_0044453

cytoplasmic translation
IAO_0000115: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
has OBO namespace: biological_process
id: GO:0002181
in subset: goslim pombe
in subset: goslim yeast
type: Class
subclass of: GO_0006412

cytoplasmic translational elongation
IAO_0000115: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.
has OBO namespace: biological_process
id: GO:0002182
type: Class
subclass of: GO_0006414
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic translation

cytoplasmic translational initiation
IAO_0000115: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
has OBO namespace: biological_process
id: GO:0002183
type: Class
subclass of: GO_0006413
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic translation

cytoplasmic translational termination
IAO_0000115: The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
has OBO namespace: biological_process
id: GO:0002184
type: Class
subclass of: GO_0006415
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic translation

creatine kinase complex
IAO_0000115: A protein complex having creatine kinase activity.
has OBO namespace: cellular_component
id: GO:0002185
type: Class
subclass of: GO_0043234

cytosolic creatine kinase complex
IAO_0000115: A dimeric protein complex having creatine kinase activity.
has OBO namespace: cellular_component
id: GO:0002186
type: Class
subclass of: creatine kinase complex
subclass of: GO_0044445

mitochondrial creatine kinase complex
IAO_0000115: An octomeric protein complex having creatine kinase activity.
has OBO namespace: cellular_component
id: GO:0002187
type: Class
subclass of: creatine kinase complex
subclass of: GO_0044429

translation reinitiation
IAO_0000115: A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
has OBO namespace: biological_process
id: GO:0002188
type: Class
subclass of: cytoplasmic translational initiation

ribose phosphate diphosphokinase complex
IAO_0000115: A protein complex having ribose phosphate diphosphokinase activity.
has exact synonym: PRPP synthetase complex
has exact synonym: phosphoribosylpyrophosphate synthetase complex
has OBO namespace: cellular_component
id: GO:0002189
type: Class
comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits.
subclass of: GO_0043234

cap-independent translational initiation
IAO_0000115: The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
has OBO namespace: biological_process
id: GO:0002190
type: Class
subclass of: cytoplasmic translational initiation

cap-dependent translational initiation
IAO_0000115: The process where the "Cap structure" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a "molecular tag" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
has OBO namespace: biological_process
id: GO:0002191
type: Class
subclass of: cytoplasmic translational initiation

IRES-dependent translational initiation
IAO_0000115: The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
has OBO namespace: biological_process
id: GO:0002192
type: Class
subclass of: cap-independent translational initiation

MAML1-RBP-Jkappa- ICN1 complex
IAO_0000115: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
has exact synonym: MAML1-CSL-ICN1
has exact synonym: MAML1-CSL-Notch1 complex
has exact synonym: MAML1-RBP-Jkappa-Notch1 complex
has OBO namespace: cellular_component
id: GO:0002193
type: Class
subclass of: GO_0043234

hepatocyte cell migration
IAO_0000115: The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.
has OBO namespace: biological_process
id: GO:0002194
type: Class
subclass of: GO_0016477

2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
IAO_0000115: The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs.
has OBO namespace: biological_process
id: GO:0002195
type: Class
comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli.
subclass of: GO_0006400

Ser-tRNA(Ala) hydrolase activity
IAO_0000115: Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).
has OBO namespace: molecular_function
id: GO:0002196
type: Class
subclass of: aminoacyl-tRNA editing activity

xanthine dehydrogenase complex
IAO_0000115: A homodimeric protein complex having xanthine dehydrogenase activity.
has OBO namespace: cellular_component
id: GO:0002197
type: Class
subclass of: GO_0043234

S/G2 transition of mitotic cell cycle
IAO_0000115: The transition from a cell in the S phase to the G2 phase.
has OBO namespace: biological_process
id: GO:0002198
type: Class
subclass of: GO_0022402
subclass of: Restriction
  on property: part_of
  some values from: GO_0051329

zona pellucida receptor complex
IAO_0000115: A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
has OBO namespace: cellular_component
has related synonym: sperm protein complex I
id: GO:0002199
type: Class
subclass of: GO_0043234

somatic diversification of immune receptors
IAO_0000115: The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
has OBO namespace: biological_process
id: GO:0002200
type: Class
comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.
subclass of: immune system process
subclass of: Restriction
  on property: part_of
  some values from: immune system development

somatic diversification of DSCAM-based immune receptors
IAO_0000115: The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects.
has OBO namespace: biological_process
id: GO:0002201
type: Class
comment: Note that this type of immune receptor may not be limited to insects.
subclass of: somatic diversification of immune receptors

somatic diversification of variable lymphocyte receptors of jawless fish
IAO_0000115: The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish.
has OBO namespace: biological_process
id: GO:0002202
type: Class
comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762).
subclass of: somatic diversification of immune receptors

proteolysis by cytosolic proteases associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002203
type: Class
comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497).
subclass of: proteolysis associated with antigen processing and presentation

somatic recombination of immunoglobulin genes involved in immune response
IAO_0000115: The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.
has OBO namespace: biological_process
has related synonym: somatic recombination of antibody genes during immune response
has related synonym: somatic recombination of immunoglobulin genes during immune response
id: GO:0002204
type: Class
subclass of: somatic diversification of immunoglobulins involved in immune response
subclass of: GO_0016447

somatic hypermutation of immunoglobulin genes involved in immune response
IAO_0000115: Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response.
has OBO namespace: biological_process
has related synonym: somatic hypermutation of antibody genes during immune response
has related synonym: somatic hypermutation of immunoglobulin genes during immune response
id: GO:0002205
type: Class
subclass of: somatic diversification of immunoglobulins involved in immune response
subclass of: GO_0016446
subclass of: Restriction
  on property: part_of
  some values from: B cell affinity maturation

gene conversion of immunoglobulin genes
IAO_0000115: The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion.
has exact synonym: gene conversion of antibody genes
has OBO namespace: biological_process
id: GO:0002206
type: Class
subclass of: somatic diversification of immune receptors via gene conversion
subclass of: GO_0016445
subclass of: GO_0035822

gene conversion of immunoglobulin genes involved in immune response
IAO_0000115: The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response.
has OBO namespace: biological_process
has related synonym: gene conversion of antibody genes during immune response
has related synonym: gene conversion of immunoglobulin genes during immune response
id: GO:0002207
type: Class
subclass of: gene conversion of immunoglobulin genes
subclass of: somatic diversification of immunoglobulins involved in immune response

somatic diversification of immunoglobulins involved in immune response
IAO_0000115: The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.
has OBO namespace: biological_process
has related synonym: somatic diversification of antibodies during immune response
has related synonym: somatic diversification of immunoglobulins during immune response
id: GO:0002208
type: Class
subclass of: GO_0016445
subclass of: Restriction
  on property: part_of
  some values from: immunoglobulin production involved in immunoglobulin mediated immune response

behavioral defense response
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat to that organism.
has exact synonym: behavioural defense response
has OBO namespace: biological_process
id: GO:0002209
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0006952
subclass of: GO_0007610

behavioral response to wounding
IAO_0000115: A behavioral response resulting from wounding.
has exact synonym: behavioural response to wounding
has OBO namespace: biological_process
id: GO:0002210
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0009611
subclass of: GO_0044708

behavioral defense response to insect
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism.
has exact synonym: behavioural defense response to insect
has OBO namespace: biological_process
id: GO:0002211
type: Class
subclass of: behavioral defense response
subclass of: defense response to insect
subclass of: GO_0051705

behavioral defense response to nematode
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism.
has exact synonym: behavioural defense response to nematode
has OBO namespace: biological_process
id: GO:0002212
type: Class
subclass of: behavioral defense response
subclass of: defense response to nematode
subclass of: GO_0051705

defense response to insect
IAO_0000115: A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.
has alternative id: GO:0002214
has exact synonym: physiological defense response to insect
has OBO namespace: biological_process
id: GO:0002213
type: Class
subclass of: GO_0006952
subclass of: GO_0009625

defense response to nematode
IAO_0000115: A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
has alternative id: GO:0002216
has exact synonym: physiological defense response to nematode
has OBO namespace: biological_process
id: GO:0002215
type: Class
subclass of: GO_0006952
subclass of: GO_0009624

activation of innate immune response
IAO_0000115: Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
has alternative id: GO:0002219
has db xref: Reactome:REACT_75835
has OBO namespace: biological_process
id: GO:0002218
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: activation of immune response
subclass of: GO_0045089

innate immune response activating cell surface receptor signaling pathway
IAO_0000115: Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor.
has exact synonym: activation of innate immune response by cell surface receptor signaling pathway
has exact synonym: innate immune response activating cell surface receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002220
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway
subclass of: innate immune response-activating signal transduction

pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
has exact synonym: PAMP receptor signaling pathway
has exact synonym: PRR signaling pathway
has exact synonym: pathogen receptor signaling pathway
has exact synonym: pathogen receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002221
type: Class
subclass of: innate immune response-activating signal transduction

stimulatory killer cell immunoglobulin-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation.
has exact synonym: stimulatory KIR signaling pathway
has exact synonym: stimulatory killer cell immunoglobulin-like receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002222
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: innate immune response activating cell surface receptor signaling pathway

stimulatory C-type lectin receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
has exact synonym: stimulatory C-type lectin receptor signalling pathway
has narrow synonym: stimulatory Ly49 family receptor signaling pathway.
has OBO namespace: biological_process
id: GO:0002223
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: innate immune response activating cell surface receptor signaling pathway

toll-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has db xref: Reactome:REACT_25035
has exact synonym: TLR signaling pathway
has exact synonym: toll-like receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002224
type: Class
comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
subclass of: pattern recognition receptor signaling pathway

positive regulation of antimicrobial peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
has exact synonym: antimicrobial peptide induction
has exact synonym: up regulation of antimicrobial peptide production
has exact synonym: up-regulation of antimicrobial peptide production
has exact synonym: upregulation of antimicrobial peptide production
has narrow synonym: activation of antimicrobial peptide production
has narrow synonym: stimulation of antimicrobial peptide production
has OBO namespace: biological_process
id: GO:0002225
type: Class
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial peptide production
subclass of: Restriction
  on property: RO_0002213
  some values from: antimicrobial peptide production

innate immune response in mucosa
IAO_0000115: Any process of the innate immune response that takes place in the mucosal tissues.
has OBO namespace: biological_process
id: GO:0002227
type: Class
subclass of: mucosal immune response
subclass of: GO_0045087

natural killer cell mediated immunity
IAO_0000115: The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
has exact synonym: NK cell mediated immunity
has OBO namespace: biological_process
id: GO:0002228
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: lymphocyte mediated immunity
subclass of: GO_0045087

defense response to oomycetes
IAO_0000115: Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.
has OBO namespace: biological_process
id: GO:0002229
type: Class
subclass of: response to oomycetes
subclass of: GO_0006952

positive regulation of defense response to virus by host
IAO_0000115: Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
has exact synonym: positive regulation of antiviral response by host
has exact synonym: up regulation of antiviral response by host
has exact synonym: up-regulation of antiviral response by host
has exact synonym: upregulation of antiviral response by host
has narrow synonym: activation of antiviral response by host
has narrow synonym: stimulation of antiviral response by host
has OBO namespace: biological_process
id: GO:0002230
type: Class
subclass of: GO_0050691

detection of oomycetes
IAO_0000115: The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0002231
type: Class
subclass of: response to oomycetes
subclass of: GO_0009581
subclass of: GO_0009595

leukocyte chemotaxis involved in inflammatory response
IAO_0000115: The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
has OBO namespace: biological_process
has related synonym: immune cell chemotaxis during inflammatory response
has related synonym: leucocyte chemotaxis during inflammatory response
has related synonym: leukocyte chemotaxis during inflammatory response
id: GO:0002232
type: Class
subclass of: leukocyte migration involved in inflammatory response
subclass of: GO_0030595
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

leukocyte chemotaxis involved in immune response
IAO_0000115: The movement of an immune cell in response to an external stimulus a part of an immune response.
has exact synonym: immune cell chemotaxis during immune response
has exact synonym: leucocyte chemotaxis during immune response
has OBO namespace: biological_process
id: GO:0002233
type: Class
subclass of: leukocyte migration involved in immune response
subclass of: GO_0030595
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

detection of endoplasmic reticulum overloading
IAO_0000115: The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.
has exact synonym: detection of ER overloading
has OBO namespace: biological_process
id: GO:0002234
type: Class
subclass of: GO_0006983
subclass of: GO_0009595

detection of unfolded protein
IAO_0000115: The series of events in which an unfolded protein stimulus is received and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0002235
type: Class
subclass of: GO_0006986
subclass of: GO_0009593

detection of misfolded protein
IAO_0000115: The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0002236
type: Class
subclass of: GO_0009593
subclass of: GO_0051788

response to molecule of bacterial origin
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
has exact synonym: response to bacteria associated molecule
has exact synonym: response to bacterial associated molecule
has exact synonym: response to bacterium associated molecule
has OBO namespace: biological_process
id: GO:0002237
type: Class
subclass of: GO_0009607
subclass of: GO_0010033
subclass of: Restriction
  on property: part_of
  some values from: GO_0009617

response to molecule of fungal origin
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
has exact synonym: response to fungus associated molecule
has OBO namespace: biological_process
id: GO:0002238
type: Class
subclass of: GO_0009607
subclass of: GO_0010033
subclass of: Restriction
  on property: part_of
  some values from: GO_0009620

response to oomycetes
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes.
has OBO namespace: biological_process
id: GO:0002239
type: Class
subclass of: GO_0051707

response to molecule of oomycetes origin
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin.
has exact synonym: response to oomycetes associated molecule
has OBO namespace: biological_process
id: GO:0002240
type: Class
subclass of: GO_0009607
subclass of: GO_0010033
subclass of: Restriction
  on property: part_of
  some values from: response to oomycetes

response to parasitic plant
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant.
has OBO namespace: biological_process
id: GO:0002241
type: Class
subclass of: GO_0009608

defense response to parasitic plant
IAO_0000115: Reactions triggered in response to the presence of a parasitic plant that act to protect an organism.
has OBO namespace: biological_process
id: GO:0002242
type: Class
subclass of: response to parasitic plant
subclass of: GO_0006952

detection of parasitic plant
IAO_0000115: The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0002243
type: Class
subclass of: response to parasitic plant
subclass of: GO_0009602

hematopoietic progenitor cell differentiation
IAO_0000115: The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
has exact synonym: haematopoietic progenitor cell differentiation
has exact synonym: haemopoietic progenitor cell differentiation
has exact synonym: hemopoietic progenitor cell differentiation
has OBO namespace: biological_process
id: GO:0002244
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0030097

wound healing involved in inflammatory response
IAO_0000115: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
has OBO namespace: biological_process
has related synonym: healing during inflammatory response
has related synonym: inflammatory response wound healing
id: GO:0002246
type: Class
subclass of: GO_0042060
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

clearance of damaged tissue involved in inflammatory response wound healing
IAO_0000115: The series of events leading to removal of necrotic debris that contribute to an inflammatory response.
has OBO namespace: biological_process
has related synonym: clearance of damaged tissue during inflammatory response
id: GO:0002247
type: Class
subclass of: GO_0048771
subclass of: Restriction
  on property: part_of
  some values from: wound healing involved in inflammatory response

connective tissue replacement involved in inflammatory response wound healing
IAO_0000115: The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.
has narrow synonym: fibrosis during inflammatory response
has OBO namespace: biological_process
has related synonym: connective tissue replacement during inflammatory response
id: GO:0002248
type: Class
subclass of: GO_0048771
subclass of: Restriction
  on property: part_of
  some values from: wound healing involved in inflammatory response

lymphocyte anergy
IAO_0000115: Any process contributing to lymphocyte anergy, a state of functional inactivation.
has OBO namespace: biological_process
id: GO:0002249
type: Class
subclass of: tolerance induction

adaptive immune response
IAO_0000115: An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
has db xref: Wikipedia:Adaptive_immune_system
has exact synonym: acquired immune response
has OBO namespace: biological_process
id: GO:0002250
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0006955

organ or tissue specific immune response
IAO_0000115: An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.
has exact synonym: immune response in organ or tissue
has OBO namespace: biological_process
id: GO:0002251
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0006955

immune effector process
IAO_0000115: Any process of the immune system that can potentially contribute to an immune response.
has OBO namespace: biological_process
id: GO:0002252
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune system process

activation of immune response
IAO_0000115: Any process that initiates an immune response.
has OBO namespace: biological_process
id: GO:0002253
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune system process
subclass of: GO_0050778

kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
has OBO namespace: biological_process
id: GO:0002254
type: Class
subclass of: acute inflammatory response
subclass of: GO_0072376

tissue kallikrein-kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
has exact synonym: glandular kallikrein-kinin cascade
has OBO namespace: biological_process
id: GO:0002255
type: Class
subclass of: kinin cascade

regulation of kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the kinin cascade.
has OBO namespace: biological_process
id: GO:0002256
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_2000257
subclass of: Restriction
  on property: RO_0002211
  some values from: kinin cascade

negative regulation of kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.
has exact synonym: down regulation of kinin cascade
has exact synonym: down-regulation of kinin cascade
has exact synonym: downregulation of kinin cascade
has narrow synonym: inhibition of kinin cascade
has OBO namespace: biological_process
id: GO:0002257
type: Class
subclass of: regulation of kinin cascade
subclass of: negative regulation of acute inflammatory response
subclass of: GO_2000258
subclass of: Restriction
  on property: RO_0002212
  some values from: kinin cascade

positive regulation of kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the kinin cascade.
has exact synonym: up regulation of kinin cascade
has exact synonym: up-regulation of kinin cascade
has exact synonym: upregulation of kinin cascade
has narrow synonym: activation of kinin cascade
has narrow synonym: stimulation of kinin cascade
has OBO namespace: biological_process
id: GO:0002258
type: Class
subclass of: regulation of kinin cascade
subclass of: positive regulation of acute inflammatory response
subclass of: GO_2000259
subclass of: Restriction
  on property: RO_0002213
  some values from: kinin cascade

endothelial cell activation within high endothelial venule involved in immune response
IAO_0000115: A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: endothelial cell activation within high endothelial venule during immune response
id: GO:0002259
type: Class
subclass of: endothelial cell activation involved in immune response

lymphocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has OBO namespace: biological_process
id: GO:0002260
type: Class
subclass of: leukocyte homeostasis

mucosal lymphocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus.
has OBO namespace: biological_process
id: GO:0002261
type: Class
subclass of: lymphocyte homeostasis

myeloid cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has OBO namespace: biological_process
id: GO:0002262
type: Class
subclass of: immune system process
subclass of: GO_0048872

cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: cell activation during immune response
id: GO:0002263
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: cell activation
subclass of: immune effector process
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

endothelial cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: endothelial cell activation during immune response
id: GO:0002264
type: Class
subclass of: cell activation involved in immune response
subclass of: GO_0042118
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

astrocyte activation involved in immune response
IAO_0000115: A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: astrocyte activation during immune response
id: GO:0002265
type: Class
subclass of: cell activation involved in immune response
subclass of: GO_0048143
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

follicular dendritic cell activation
IAO_0000115: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
has OBO namespace: biological_process
id: GO:0002266
type: Class
subclass of: cell activation

follicular dendritic cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: follicular dendritic cell activation during immune response
id: GO:0002267
type: Class
subclass of: cell activation involved in immune response
subclass of: follicular dendritic cell activation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

follicular dendritic cell differentiation
IAO_0000115: The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.
has OBO namespace: biological_process
id: GO:0002268
type: Class
subclass of: follicular dendritic cell activation
subclass of: GO_0030154

leukocyte activation involved in inflammatory response
IAO_0000115: A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
has OBO namespace: biological_process
has related synonym: immune cell activation during inflammatory response
has related synonym: leukocyte activation during inflammatory response
id: GO:0002269
type: Class
subclass of: GO_0045321
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

plasmacytoid dendritic cell activation
IAO_0000115: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
has OBO namespace: biological_process
id: GO:0002270
type: Class
subclass of: GO_0045321

plasmacytoid dendritic cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: plasmacytoid dendritic cell activation during immune response
id: GO:0002271
type: Class
subclass of: plasmacytoid dendritic cell activation
subclass of: leukocyte activation involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

plasmacytoid dendritic cell differentiation involved in immune response
IAO_0000115: The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response.
has OBO namespace: biological_process
has related synonym: plasmacytoid dendritic cell differentiation during immune response
id: GO:0002272
type: Class
subclass of: plasmacytoid dendritic cell activation involved in immune response
subclass of: plasmacytoid dendritic cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

plasmacytoid dendritic cell differentiation
IAO_0000115: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.
has OBO namespace: biological_process
id: GO:0002273
type: Class
subclass of: plasmacytoid dendritic cell activation
subclass of: leukocyte differentiation

myeloid leukocyte activation
IAO_0000115: A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
has exact synonym: myeloid leucocyte activation
has OBO namespace: biological_process
id: GO:0002274
type: Class
subclass of: GO_0045321

myeloid cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: myeloid cell activation during immune response
id: GO:0002275
type: Class
subclass of: myeloid leukocyte activation
subclass of: leukocyte activation involved in immune response

basophil activation involved in immune response
IAO_0000115: A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: basophil activation during immune response
id: GO:0002276
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0045575
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

myeloid dendritic cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: myeloid dendritic cell activation during immune response
id: GO:0002277
type: Class
subclass of: myeloid dendritic cell activation
subclass of: myeloid cell activation involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

eosinophil activation involved in immune response
IAO_0000115: The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: eosinophil activation during immune response
id: GO:0002278
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0043307
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

mast cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: mast cell activation during immune response
id: GO:0002279
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0045576
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

monocyte activation involved in immune response
IAO_0000115: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: monocyte activation during immune response
id: GO:0002280
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0042117
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

macrophage activation involved in immune response
IAO_0000115: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: macrophage activation during immune response
id: GO:0002281
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0042116
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

microglial cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: microglial cell activation during immune response
id: GO:0002282
type: Class
subclass of: microglial cell activation
subclass of: macrophage activation involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

neutrophil activation involved in immune response
IAO_0000115: The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: neutrophil activation during immune response
id: GO:0002283
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: GO_0042119
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

myeloid dendritic cell differentiation involved in immune response
IAO_0000115: The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.
has OBO namespace: biological_process
has related synonym: myeloid dendritic cell differentiation during immune response
id: GO:0002284
type: Class
subclass of: myeloid dendritic cell activation involved in immune response
subclass of: GO_0043011
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

lymphocyte activation involved in immune response
IAO_0000115: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: lymphocyte activation during immune response
id: GO:0002285
type: Class
subclass of: leukocyte activation involved in immune response
subclass of: GO_0046649
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: T cell activation during immune response
has related synonym: T lymphocyte activation during immune response
has related synonym: T-cell activation during immune response
has related synonym: T-lymphocyte activation during immune response
id: GO:0002286
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: GO_0042110
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

alpha-beta T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: alpha-beta T cell activation during immune response
has related synonym: alpha-beta T lymphocyte activation during immune response
has related synonym: alpha-beta T-cell activation during immune response
has related synonym: alpha-beta T-lymphocyte activation during immune response
id: GO:0002287
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0046631
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

NK T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: NK T cell activation during immune response
has related synonym: NK T lymphocyte activation during immune response
has related synonym: NK T-cell activation during immune response
has related synonym: NK T-lymphocyte activation during immune response
has related synonym: natural killer T lymphocyte activation during immune response
has related synonym: natural killer T-cell activation during immune response
has related synonym: natural killer T-lymphocyte activation during immune response
id: GO:0002288
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: GO_0051132
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

NK T cell proliferation involved in immune response
IAO_0000115: The expansion of a NK T cell population by cell division as part of an immune response.
has OBO namespace: biological_process
has related synonym: NK T cell proliferation during immune response
has related synonym: NK T lymphocyte proliferation during immune response
has related synonym: NK T-cell proliferation during immune response
has related synonym: NK T-lymphocyte proliferation during immune response
has related synonym: natural killer T lymphocyte proliferation during immune response
has related synonym: natural killer T-cell proliferation during immune response
has related synonym: natural killer T-lymphocyte proliferation during immune response
id: GO:0002289
type: Class
subclass of: NK T cell proliferation
subclass of: NK T cell activation involved in immune response
subclass of: alpha-beta T cell proliferation involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

gamma-delta T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: gamma-delta T cell activation during immune response
has related synonym: gamma-delta T lymphocyte activation during immune response
has related synonym: gamma-delta T-cell activation during immune response
has related synonym: gamma-delta T-lymphocyte activation during immune response
id: GO:0002290
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0046629
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
IAO_0000115: The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
has exact synonym: T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has exact synonym: T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has exact synonym: T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has OBO namespace: biological_process
id: GO:0002291
type: Class
subclass of: T cell activation involved in immune response

T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has OBO namespace: biological_process
has related synonym: T cell development involved in immune response
has related synonym: T cell differentiation during immune response
has related synonym: T lymphocyte differentiation during immune response
has related synonym: T-cell differentiation during immune response
has related synonym: T-lymphocyte differentiation during immune response
id: GO:0002292
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: T cell activation involved in immune response
subclass of: GO_0030217
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

alpha-beta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has OBO namespace: biological_process
has related synonym: alpha-beta T cell development involved in immune response
has related synonym: alpha-beta T cell differentiation during immune response
has related synonym: alpha-beta T lymphocyte differentiation during immune response
has related synonym: alpha-beta T-cell differentiation during immune response
has related synonym: alpha-beta T-lymphocyte differentiation during immune response
id: GO:0002293
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: alpha-beta T cell activation involved in immune response
subclass of: T cell differentiation involved in immune response
subclass of: GO_0046632
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

CD4-positive, alpha-beta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has OBO namespace: biological_process
has related synonym: CD4-positive, alpha-beta T cell development involved in immune response
has related synonym: CD4-positive, alpha-beta T cell differentiation during immune response
has related synonym: CD4-positive, alpha-beta T lymphocyte differentiation during immune response
has related synonym: CD4-positive, alpha-beta T-cell differentiation during immune response
has related synonym: CD4-positive, alpha-beta T-lymphocyte differentiation during immune response
id: GO:0002294
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: alpha-beta T cell differentiation involved in immune response
subclass of: GO_0043367
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

T-helper cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.
has exact synonym: T-helper cell fate commitment
has OBO namespace: biological_process
has related synonym: Th0 lineage commitment
has related synonym: Thp lineage commitment
id: GO:0002295
type: Class
subclass of: T cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: GO_0042093

T-helper 1 cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
has exact synonym: T-helper 1 cell fate commitment
has exact synonym: Th1 cell lineage commitment
has exact synonym: Th1 fate commitment
has OBO namespace: biological_process
id: GO:0002296
type: Class
subclass of: T-helper cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: GO_0045063

T-helper 2 cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy.
has exact synonym: T-helper 2 cell fate commitment
has exact synonym: Th2 fate commitment
has OBO namespace: biological_process
id: GO:0002297
type: Class
subclass of: T-helper cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: GO_0045064

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response.
has OBO namespace: biological_process
has related synonym: CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response
id: GO:0002298
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: CD4-positive, alpha-beta T cell differentiation involved in immune response
subclass of: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

alpha-beta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: alpha-beta intraepithelial T-cell differentiation
has exact synonym: alpha-beta intraepithelial T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: alpha-beta intraepithelial T cell development
id: GO:0002299
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0046632

CD8-positive, alpha-beta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta intraepithelial T-cell differentiation
has exact synonym: CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD8-positive, alpha-beta intraepithelial T cell development
id: GO:0002300
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: alpha-beta intraepithelial T cell differentiation
subclass of: GO_0043374

CD4-positive, alpha-beta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: CD4-positive, alpha-beta intraepithelial T-cell differentiation
has exact synonym: CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD4-positive, alpha-beta intraepithelial T cell development
id: GO:0002301
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: alpha-beta intraepithelial T cell differentiation
subclass of: GO_0043367

CD8-positive, alpha-beta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has OBO namespace: biological_process
has related synonym: CD8-positive, alpha-beta T cell differentiation during immune response
has related synonym: CD8-positive, alpha-beta T lymphocyte differentiation during immune response
has related synonym: CD8-positive, alpha-beta T-cell differentiation during immune response
has related synonym: CD8-positive, alpha-beta T-lymphocyte differentiation during immune response
has related synonym: CD8-positive, alpha-beta intraepithelial T cell development
id: GO:0002302
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: alpha-beta T cell differentiation involved in immune response
subclass of: GO_0043374
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

gamma-delta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has OBO namespace: biological_process
has related synonym: gamma-delta T cell development involved in immune response
has related synonym: gamma-delta T cell differentiation during immune response
has related synonym: gamma-delta T lymphocyte differentiation during immune response
has related synonym: gamma-delta T-cell differentiation during immune response
has related synonym: gamma-delta T-lymphocyte differentiation during immune response
id: GO:0002303
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: gamma-delta T cell activation involved in immune response
subclass of: T cell differentiation involved in immune response
subclass of: GO_0042492
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: gamma-delta intraepithelial T-cell differentiation
has exact synonym: gamma-delta intraepithelial T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: gamma-delta intraepithelial T cell development
id: GO:0002304
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0042492

CD8-positive, gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: CD8-positive, gamma-delta intraepithelial T-cell differentiation
has exact synonym: CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD8-positive, gamma-delta intraepithelial T cell development
id: GO:0002305
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: gamma-delta intraepithelial T cell differentiation

CD4-positive gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: CD4-positive, gamma-delta intraepithelial T-cell differentiation
has exact synonym: CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD4-positive, gamma-delta intraepithelial T cell development
id: GO:0002306
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: gamma-delta intraepithelial T cell differentiation

CD8-positive, alpha-beta regulatory T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell.
has exact synonym: CD8-positive, alpha-beta regulatory T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta regulatory T-cell differentiation
has exact synonym: CD8-positive, alpha-beta regulatory T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD8-positive, alpha-beta regulatory T cell development
id: GO:0002307
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0043374
subclass of: GO_0045066

CD8-positive, alpha-beta cytotoxic T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell.
has exact synonym: CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta cytotoxic T-cell differentiation
has exact synonym: CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD8-positive, alpha-beta cytotoxic T cell development
id: GO:0002308
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0043374
subclass of: GO_0045065

T cell proliferation involved in immune response
IAO_0000115: The expansion of a T cell population by cell division as part of an immune response.
has OBO namespace: biological_process
has related synonym: T cell proliferation during immune response
has related synonym: T lymphocyte proliferation during immune response
has related synonym: T-cell proliferation during immune response
has related synonym: T-lymphocyte proliferation during immune response
id: GO:0002309
type: Class
subclass of: T cell activation involved in immune response
subclass of: GO_0042098
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

alpha-beta T cell proliferation involved in immune response
IAO_0000115: The expansion of an alpha-beta T cell population by cell division as part of an immune response.
has OBO namespace: biological_process
has related synonym: alpha-beta T cell proliferation during immune response
has related synonym: alpha-beta T lymphocyte proliferation during immune response
has related synonym: alpha-beta T-cell proliferation during immune response
has related synonym: alpha-beta T-lymphocyte proliferation during immune response
id: GO:0002310
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: T cell proliferation involved in immune response
subclass of: GO_0046633
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

gamma-delta T cell proliferation involved in immune response
IAO_0000115: The expansion of a gamma-delta T cell population by cell division as part of an immune response.
has OBO namespace: biological_process
has related synonym: gamma-delta T cell proliferation during immune response
has related synonym: gamma-delta T lymphocyte proliferation during immune response
has related synonym: gamma-delta T-cell proliferation during immune response
has related synonym: gamma-delta T-lymphocyte proliferation during immune response
id: GO:0002311
type: Class
subclass of: gamma-delta T cell activation involved in immune response
subclass of: T cell proliferation involved in immune response
subclass of: GO_0046630
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

B cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
has OBO namespace: biological_process
has related synonym: B cell activation during immune response
has related synonym: B lymphocyte activation during immune response
has related synonym: B-cell activation during immune response
has related synonym: B-lymphocyte activation during immune response
id: GO:0002312
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: GO_0042113
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

mature B cell differentiation involved in immune response
IAO_0000115: The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.
has OBO namespace: biological_process
has related synonym: mature B cell development involved in immune response
has related synonym: mature B cell differentiation during immune response
has related synonym: mature B lymphocyte differentiation during immune response
has related synonym: mature B-cell differentiation during immune response
has related synonym: mature B-lymphocyte differentiation during immune response
id: GO:0002313
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: B cell activation involved in immune response
subclass of: mature B cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

germinal center B cell differentiation
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
has exact synonym: germinal center B lymphocyte differentiation
has exact synonym: germinal center B-cell differentiation
has exact synonym: germinal center B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: germinal center B cell development
id: GO:0002314
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: mature B cell differentiation involved in immune response

marginal zone B cell differentiation
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
has exact synonym: marginal zone B lymphocyte differentiation
has exact synonym: marginal zone B-cell differentiation
has exact synonym: marginal zone B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: marginal zone B cell development
id: GO:0002315
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: mature B cell differentiation involved in immune response

follicular B cell differentiation
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.
has exact synonym: follicular B lymphocyte differentiation
has exact synonym: follicular B-cell differentiation
has exact synonym: follicular B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: follicular B cell development
id: GO:0002316
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: mature B cell differentiation involved in immune response

plasma cell differentiation
IAO_0000115: The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
has OBO namespace: biological_process
has related synonym: plasma cell development
id: GO:0002317
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: mature B cell differentiation involved in immune response

myeloid progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.
has OBO namespace: biological_process
id: GO:0002318
type: Class
subclass of: hematopoietic progenitor cell differentiation

memory B cell differentiation
IAO_0000115: The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.
has exact synonym: memory B lymphocyte differentiation
has exact synonym: memory B-cell differentiation
has exact synonym: memory B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: memory B cell development
id: GO:0002319
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: mature B cell differentiation involved in immune response

lymphoid progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.
has OBO namespace: biological_process
id: GO:0002320
type: Class
subclass of: hematopoietic progenitor cell differentiation

natural killer cell progenitor differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.
has OBO namespace: biological_process
id: GO:0002321
type: Class
subclass of: lymphoid progenitor cell differentiation

B cell proliferation involved in immune response
IAO_0000115: The expansion of a B cell population by cell division following B cell activation during an immune response.
has OBO namespace: biological_process
has related synonym: B cell proliferation during immune response
has related synonym: B lymphocyte proliferation during immune response
has related synonym: B-cell proliferation during immune response
has related synonym: B-lymphocyte proliferation during immune response
id: GO:0002322
type: Class
subclass of: B cell activation involved in immune response
subclass of: GO_0042100
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

natural killer cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: NK cell activation during immune response
has related synonym: natural killer cell activation during immune response
id: GO:0002323
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: GO_0030101
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

natural killer cell proliferation involved in immune response
IAO_0000115: The expansion of a natural killer cell population by cell division as part of an immune response.
has OBO namespace: biological_process
has related synonym: NK cell proliferation during immune response
has related synonym: natural killer cell proliferation during immune response
id: GO:0002324
type: Class
subclass of: natural killer cell proliferation
subclass of: natural killer cell activation involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

natural killer cell differentiation involved in immune response
IAO_0000115: The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.
has OBO namespace: biological_process
has related synonym: NK cell differentiation during immune response
has related synonym: natural killer cell development involved in immune response
has related synonym: natural killer cell differentiation during immune response
id: GO:0002325
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: natural killer cell differentiation
subclass of: natural killer cell activation involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

B cell lineage commitment
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.
has exact synonym: B lymphocyte lineage commitment
has exact synonym: B-cell lineage commitment
has exact synonym: B-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002326
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: GO_0030183

immature B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of an immature B cell.
has exact synonym: immature B lymphocyte differentiation
has exact synonym: immature B-cell differentiation
has exact synonym: immature B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: immature B cell development
id: GO:0002327
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0030183

pro-B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
has exact synonym: pro-B lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: pro-B cell development
id: GO:0002328
type: Class
subclass of: lymphoid progenitor cell differentiation

pre-B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
has exact synonym: pre-B lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: pre-B cell development
id: GO:0002329
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: immature B cell differentiation

pre-B cell receptor expression
IAO_0000115: The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface.
has OBO namespace: biological_process
id: GO:0002330
type: Class
subclass of: pre-B cell differentiation

pre-B cell allelic exclusion
IAO_0000115: Expression of a single heavy chain allele during pre-B cell differentiation.
has exact synonym: pre-B lymphocyte allelic exclusion
has OBO namespace: biological_process
id: GO:0002331
type: Class
subclass of: pre-B cell differentiation

transitional stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.
has exact synonym: transitional stage B lymphocyte differentiation
has exact synonym: transitional stage B-cell differentiation
has exact synonym: transitional stage B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: transitional stage B cell development
id: GO:0002332
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: immature B cell differentiation

transitional one stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
has exact synonym: T1 stage B cell differentiation
has exact synonym: transitional one stage B lymphocyte differentiation
has exact synonym: transitional one stage B-cell differentiation
has exact synonym: transitional one stage B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: transitional one stage B cell development
id: GO:0002333
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: transitional stage B cell differentiation

transitional two stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.
has exact synonym: T2 stage B cell differentiation
has exact synonym: transitional two stage B lymphocyte differentiation
has exact synonym: transitional two stage B-cell differentiation
has exact synonym: transitional two stage B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: transitional two stage B cell development
id: GO:0002334
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: transitional stage B cell differentiation

mature B cell differentiation
IAO_0000115: The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
has exact synonym: mature B lymphocyte differentiation
has exact synonym: mature B-cell differentiation
has exact synonym: mature B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: mature cell development
id: GO:0002335
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0030183

B-1 B cell lineage commitment
IAO_0000115: The process in which an immature B cell becomes committed to become a B-1 B cell.
has exact synonym: B-1 B lymphocyte lineage commitment
has exact synonym: B-1 B-cell lineage commitment
has exact synonym: B-1 B-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002336
type: Class
subclass of: B cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: B-1 B cell differentiation

B-1a B cell differentiation
IAO_0000115: The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
has exact synonym: B-1a B lymphocyte differentiation
has exact synonym: B-1a B-cell differentiation
has exact synonym: B-1a B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: B-1a B cell development
id: GO:0002337
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: B-1 B cell differentiation

B-1b B cell differentiation
IAO_0000115: The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.
has exact synonym: B-1b B lymphocyte differentiation
has exact synonym: B-1b B-cell differentiation
has exact synonym: B-1b B-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: B-1b B cell development
id: GO:0002338
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: B-1 B cell differentiation

B cell selection
IAO_0000115: The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
has exact synonym: B lymphocyte selection
has exact synonym: B-cell selection
has exact synonym: B-lymphocyte selection
has OBO namespace: biological_process
id: GO:0002339
type: Class
subclass of: immune system process
subclass of: Restriction
  on property: part_of
  some values from: GO_0030183

central B cell selection
IAO_0000115: Any B cell selection process that occurs in the bone marrow.
has exact synonym: central B lymphocyte selection
has exact synonym: central B-cell selection
has exact synonym: central B-lymphocyte selection
has OBO namespace: biological_process
id: GO:0002340
type: Class
subclass of: B cell selection

central B cell anergy
IAO_0000115: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.
has exact synonym: central B lymphocyte anergy
has exact synonym: central B-cell anergy
has exact synonym: central B-lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002341
type: Class
subclass of: B cell anergy
subclass of: Restriction
  on property: part_of
  some values from: central B cell selection
subclass of: Restriction
  on property: part_of
  some values from: central B cell tolerance induction

central B cell deletion
IAO_0000115: The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.
has exact synonym: central B lymphocyte deletion
has exact synonym: central B-cell deletion
has exact synonym: central B-lymphocyte deletion
has OBO namespace: biological_process
id: GO:0002342
type: Class
subclass of: B cell deletion
subclass of: Restriction
  on property: part_of
  some values from: central B cell selection
subclass of: Restriction
  on property: part_of
  some values from: central B cell tolerance induction

peripheral B cell selection
IAO_0000115: Any B cell selection process that occurs in the periphery.
has exact synonym: peripheral B lymphocyte selection
has exact synonym: peripheral B-cell selection
has exact synonym: peripheral B-lymphocyte selection
has OBO namespace: biological_process
id: GO:0002343
type: Class
subclass of: B cell selection

B cell affinity maturation
IAO_0000115: The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
has exact synonym: B lymphocyte affinity maturation
has exact synonym: B-cell affinity maturation
has exact synonym: B-lymphocyte affinity maturation
has OBO namespace: biological_process
id: GO:0002344
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: peripheral B cell selection
subclass of: Restriction
  on property: part_of
  some values from: immunoglobulin production involved in immunoglobulin mediated immune response

peripheral B cell receptor editing
IAO_0000115: The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.
has exact synonym: peripheral B lymphocyte receptor editing
has exact synonym: peripheral B-cell receptor editing
has exact synonym: peripheral B-lymphocyte receptor editing
has OBO namespace: biological_process
id: GO:0002345
type: Class
subclass of: B cell receptor editing

B cell positive selection
IAO_0000115: Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor.
has exact synonym: B lymphocyte positive selection
has exact synonym: B-cell positive selection
has exact synonym: B-lymphocyte positive selection
has OBO namespace: biological_process
id: GO:0002346
type: Class
subclass of: B cell selection

response to tumor cell
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.
has OBO namespace: biological_process
id: GO:0002347
type: Class
subclass of: GO_0009607

central B cell positive selection
IAO_0000115: Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
has exact synonym: central B lymphocyte positive selection
has exact synonym: central B-cell positive selection
has exact synonym: central B-lymphocyte positive selection
has OBO namespace: biological_process
id: GO:0002348
type: Class
subclass of: central B cell selection
subclass of: B cell positive selection

histamine production involved in inflammatory response
IAO_0000115: The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: histamine production involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002349
type: Class
subclass of: production of molecular mediator involved in inflammatory response

peripheral B cell positive selection
IAO_0000115: Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
has exact synonym: peripheral B lymphocyte positive selection
has exact synonym: peripheral B-cell positive selection
has exact synonym: peripheral B-lymphocyte positive selection
has OBO namespace: biological_process
id: GO:0002350
type: Class
subclass of: peripheral B cell selection
subclass of: B cell positive selection

serotonin production involved in inflammatory response
IAO_0000115: The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: serotonin production involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002351
type: Class
subclass of: production of molecular mediator involved in inflammatory response

B cell negative selection
IAO_0000115: Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.
has exact synonym: B lymphocyte negative selection
has exact synonym: B-cell negative selection
has exact synonym: B-lymphocyte negative selection
has OBO namespace: biological_process
id: GO:0002352
type: Class
subclass of: B cell selection

plasma kallikrein-kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
has OBO namespace: biological_process
id: GO:0002353
type: Class
subclass of: kinin cascade

central B cell negative selection
IAO_0000115: Any process leading to negative selection of B cells in the bone marrow.
has exact synonym: central B lymphocyte negative selection
has exact synonym: central B-cell negative selection
has exact synonym: central B-lymphocyte negative selection
has OBO namespace: biological_process
id: GO:0002354
type: Class
subclass of: central B cell selection
subclass of: B cell negative selection

detection of tumor cell
IAO_0000115: The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0002355
type: Class
subclass of: response to tumor cell
subclass of: GO_0009595

peripheral B cell negative selection
IAO_0000115: Any process leading to negative selection of B cells in the periphery.
has exact synonym: peripheral B lymphocyte negative selection
has exact synonym: peripheral B-cell negative selection
has exact synonym: peripheral B-lymphocyte negative selection
has OBO namespace: biological_process
id: GO:0002356
type: Class
subclass of: peripheral B cell selection
subclass of: B cell negative selection

defense response to tumor cell
IAO_0000115: Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
has OBO namespace: biological_process
id: GO:0002357
type: Class
subclass of: response to tumor cell
subclass of: GO_0006952

B cell homeostatic proliferation
IAO_0000115: The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.
has exact synonym: B lymphocyte homeostatic proliferation
has exact synonym: B-cell homeostatic proliferation
has exact synonym: B-lymphocyte homeostatic proliferation
has OBO namespace: biological_process
id: GO:0002358
type: Class
subclass of: GO_0042100

B-1 B cell proliferation
IAO_0000115: The expansion of a B-1 B cell by cell division. Follows B cell activation.
has exact synonym: B-1 B lymphocyte proliferation
has exact synonym: B-1 B-cell proliferation
has exact synonym: B-1 B-lymphocyte proliferation
has OBO namespace: biological_process
id: GO:0002359
type: Class
subclass of: GO_0042100

T cell lineage commitment
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
has exact synonym: T lymphocyte lineage commitment
has exact synonym: T-cell lineage commitment
has exact synonym: T-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002360
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: GO_0030217

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation
has OBO namespace: biological_process
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell development
id: GO:0002361
type: Class
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
subclass of: GO_0043367
subclass of: GO_0045066

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002362
type: Class
subclass of: T cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta T cell lineage commitment
IAO_0000115: The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.
has exact synonym: alpha-beta T lymphocyte lineage commitment
has exact synonym: alpha-beta T-cell lineage commitment
has exact synonym: alpha-beta T-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002363
type: Class
subclass of: T cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: GO_0046632

NK T cell lineage commitment
IAO_0000115: The process in which a pro-T cell becomes committed to becoming an NK T cell.
has exact synonym: NK T lymphocyte lineage commitment
has exact synonym: NK T-cell lineage commitment
has exact synonym: NK T-lymphocyte lineage commitment
has exact synonym: natural killer T lymphocyte lineage commitment
has exact synonym: natural killer T-cell lineage commitment
has exact synonym: natural killer T-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002364
type: Class
subclass of: T cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: NK T cell differentiation

gamma-delta T cell lineage commitment
IAO_0000115: The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.
has exact synonym: gamma-delta T lymphocyte lineage commitment
has exact synonym: gamma-delta T-cell lineage commitment
has exact synonym: gamma-delta T-lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002365
type: Class
subclass of: T cell lineage commitment
subclass of: Restriction
  on property: part_of
  some values from: GO_0042492

leukocyte activation involved in immune response
IAO_0000115: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has OBO namespace: biological_process
has related synonym: immune cell activation during immune response
has related synonym: leucocyte activation during immune response
has related synonym: leukocyte activation during immune response
id: GO:0002366
type: Class
subclass of: cell activation involved in immune response
subclass of: GO_0045321
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

cytokine production involved in immune response
IAO_0000115: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
has OBO namespace: biological_process
has related synonym: cytokine production during immune response
id: GO:0002367
type: Class
comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
subclass of: cytokine production
subclass of: production of molecular mediator of immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

B cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a B cell.
has exact synonym: B lymphocyte cytokine production
has exact synonym: B-cell cytokine production
has exact synonym: B-lymphocyte cytokine production
has OBO namespace: biological_process
id: GO:0002368
type: Class
subclass of: cytokine production involved in immune response
subclass of: GO_0019724

T cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a T cell.
has exact synonym: T lymphocyte cytokine production
has exact synonym: T-cell cytokine production
has exact synonym: T-lymphocyte cytokine production
has OBO namespace: biological_process
id: GO:0002369
type: Class
subclass of: cytokine production involved in immune response
subclass of: T cell mediated immunity

natural killer cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a natural killer cell.
has exact synonym: NK cell cytokine production
has OBO namespace: biological_process
id: GO:0002370
type: Class
subclass of: natural killer cell mediated immunity
subclass of: cytokine production involved in immune response

dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a dendritic cell.
has OBO namespace: biological_process
id: GO:0002371
type: Class
subclass of: cytokine production involved in immune response

myeloid dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a myeloid dendritic cell.
has OBO namespace: biological_process
id: GO:0002372
type: Class
subclass of: dendritic cell cytokine production
subclass of: GO_0061082

plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.
has OBO namespace: biological_process
id: GO:0002373
type: Class
subclass of: dendritic cell cytokine production

cytokine secretion involved in immune response
IAO_0000115: The regulated release of cytokines from a cell or group of cells that contributes to an immune response.
has OBO namespace: biological_process
has related synonym: cytokine secretion during immune response
id: GO:0002374
type: Class
subclass of: GO_0050663
subclass of: Restriction
  on property: part_of
  some values from: cytokine production involved in immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

cytokine biosynthetic process involved in immune response
IAO_0000115: The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response.
has OBO namespace: biological_process
has related synonym: cytokine biosynthetic process during immune response
id: GO:0002375
type: Class
subclass of: GO_0042089
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955
subclass of: Restriction
  on property: part_of
  some values from: cytokine production involved in immune response

immune system process
IAO_0000115: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
has db xref: Wikipedia:Immune_system
has OBO namespace: biological_process
id: GO:0002376
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
type: Class
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
subclass of: GO_0008150

immunoglobulin production
IAO_0000115: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has exact synonym: antibody production
has OBO namespace: biological_process
id: GO:0002377
type: Class
subclass of: production of molecular mediator of immune response

immunoglobulin biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of immunoglobulin.
has exact synonym: antibody biosynthesis
has exact synonym: antibody biosynthetic process
has OBO namespace: biological_process
id: GO:0002378
type: Class
subclass of: GO_0009059
subclass of: Restriction
  on property: part_of
  some values from: immunoglobulin production

immunoglobulin biosynthetic process involved in immune response
IAO_0000115: The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response.
has OBO namespace: biological_process
has related synonym: antibody biosynthesis during immune response
has related synonym: antibody biosynthetic process during immune response
has related synonym: immunoglobulin biosynthetic process during immune response
id: GO:0002379
type: Class
subclass of: immunoglobulin biosynthetic process
subclass of: Restriction
  on property: part_of
  some values from: immunoglobulin production involved in immunoglobulin mediated immune response

immunoglobulin secretion involved in immune response
IAO_0000115: The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response.
has OBO namespace: biological_process
has related synonym: antibody secretion during immune response
has related synonym: immunoglobulin secretion during immune response
id: GO:0002380
type: Class
subclass of: GO_0048305
subclass of: Restriction
  on property: part_of
  some values from: immunoglobulin production involved in immunoglobulin mediated immune response

immunoglobulin production involved in immunoglobulin mediated immune response
IAO_0000115: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
has OBO namespace: biological_process
has related synonym: antibody production during immune response
has related synonym: immunoglobulin production during immune response
has related synonym: immunoglobulin production involved in immune response
id: GO:0002381
type: Class
subclass of: immunoglobulin production
subclass of: Restriction
  on property: part_of
  some values from: GO_0016064

regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: regulation of glandular kallikrein-kinin cascade
has OBO namespace: biological_process
id: GO:0002382
type: Class
subclass of: regulation of kinin cascade
subclass of: Restriction
  on property: RO_0002211
  some values from: tissue kallikrein-kinin cascade

immune response in brain or nervous system
IAO_0000115: An immune response taking place in the brain or nervous system.
has OBO namespace: biological_process
id: GO:0002383
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: organ or tissue specific immune response

hepatic immune response
IAO_0000115: An immune response taking place in the liver.
has OBO namespace: biological_process
id: GO:0002384
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: organ or tissue specific immune response

mucosal immune response
IAO_0000115: An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
has OBO namespace: biological_process
id: GO:0002385
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: organ or tissue specific immune response

immune response in mucosal-associated lymphoid tissue
IAO_0000115: Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes.
has exact synonym: immune response in MALT
has OBO namespace: biological_process
id: GO:0002386
type: Class
subclass of: mucosal immune response

immune response in gut-associated lymphoid tissue
IAO_0000115: Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.
has exact synonym: immune response in GALT
has OBO namespace: biological_process
id: GO:0002387
type: Class
subclass of: immune response in mucosal-associated lymphoid tissue

immune response in Peyer's patch
IAO_0000115: Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine.
has OBO namespace: biological_process
id: GO:0002388
type: Class
subclass of: immune response in gut-associated lymphoid tissue

tolerance induction in Peyer's patch
IAO_0000115: Tolerance induction taking place in the Peyer's patches.
has OBO namespace: biological_process
id: GO:0002389
type: Class
subclass of: immune response in Peyer's patch
subclass of: tolerance induction in gut-associated lymphoid tissue

platelet activating factor production
IAO_0000115: The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels.
has OBO namespace: biological_process
id: GO:0002390
type: Class
subclass of: cytokine production

platelet activating factor production involved in inflammatory response
IAO_0000115: The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: platelet activating factor production involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002391
type: Class
subclass of: platelet activating factor production
subclass of: cytokine production involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

platelet activating factor secretion
IAO_0000115: The regulated release of platelet activating factor by a cell or group of cells.
has OBO namespace: biological_process
id: GO:0002392
type: Class
subclass of: GO_0006812
subclass of: GO_0015697
subclass of: GO_0015850
subclass of: GO_0015914
subclass of: GO_0050663

lysosomal enzyme production involved in inflammatory response
IAO_0000115: The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels.
has broad synonym: lysosomal enzyme production involved in acute inflammatory response
has broad synonym: production of lysosomal enzymes involved in acute inflammatory response
has exact synonym: production of lysosomal enzymes involved in inflammatory response
has OBO namespace: biological_process
id: GO:0002393
type: Class
subclass of: production of molecular mediator involved in inflammatory response

tolerance induction in gut-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the gut-associated lymphoid tissue (GALT).
has exact synonym: tolerance induction in GALT
has OBO namespace: biological_process
has related synonym: oral tolerance
id: GO:0002394
type: Class
subclass of: immune response in gut-associated lymphoid tissue
subclass of: tolerance induction in mucosal-associated lymphoid tissue

immune response in nasopharyngeal-associated lymphoid tissue
IAO_0000115: An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.
has exact synonym: immune response in NALT
has OBO namespace: biological_process
id: GO:0002395
type: Class
subclass of: immune response in mucosal-associated lymphoid tissue

MHC protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002396
type: Class
subclass of: GO_0043623

MHC class I protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.
has OBO namespace: biological_process
id: GO:0002397
type: Class
subclass of: MHC protein complex assembly

MHC class Ib protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules.
has OBO namespace: biological_process
id: GO:0002398
type: Class
subclass of: MHC protein complex assembly

MHC class II protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.
has OBO namespace: biological_process
id: GO:0002399
type: Class
subclass of: MHC protein complex assembly

tolerance induction in nasopharyngeal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).
has exact synonym: tolerance induction in NALT
has OBO namespace: biological_process
has related synonym: nasal tolerance
id: GO:0002400
type: Class
subclass of: immune response in nasopharyngeal-associated lymphoid tissue
subclass of: tolerance induction in mucosal-associated lymphoid tissue

tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).
has exact synonym: tolerance induction in MALT
has OBO namespace: biological_process
id: GO:0002401
type: Class
subclass of: immune response in mucosal-associated lymphoid tissue
subclass of: mucosal tolerance induction

B cell tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.
has exact synonym: B cell tolerance induction in MALT
has OBO namespace: biological_process
id: GO:0002402
type: Class
subclass of: tolerance induction in mucosal-associated lymphoid tissue
subclass of: peripheral B cell tolerance induction

T cell tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.
has exact synonym: T cell tolerance induction in MALT
has OBO namespace: biological_process
id: GO:0002403
type: Class
subclass of: tolerance induction in mucosal-associated lymphoid tissue
subclass of: peripheral T cell tolerance induction

antigen sampling in mucosal-associated lymphoid tissue
IAO_0000115: The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling in MALT
has OBO namespace: biological_process
has related synonym: antigen transport in MALT
has related synonym: antigen transport in mucosal-associated lymphoid tissue
id: GO:0002404
type: Class
subclass of: immune system process
subclass of: Restriction
  on property: part_of
  some values from: immune response in mucosal-associated lymphoid tissue

antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling by dendritic cells in MALT
has OBO namespace: biological_process
id: GO:0002405
type: Class
subclass of: antigen sampling in mucosal-associated lymphoid tissue
subclass of: Restriction
  on property: part_of
  some values from: dendritic cell antigen processing and presentation

antigen sampling by M cells in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling by M cells in MALT
has OBO namespace: biological_process
id: GO:0002406
type: Class
subclass of: antigen sampling in mucosal-associated lymphoid tissue

dendritic cell chemotaxis
IAO_0000115: The movement of a dendritic cell in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002407
type: Class
subclass of: GO_0030595
subclass of: GO_0036336

myeloid dendritic cell chemotaxis
IAO_0000115: The movement of a myeloid dendritic cell in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002408
type: Class
subclass of: dendritic cell chemotaxis

Langerhans cell chemotaxis
IAO_0000115: The movement of a Langerhans cell in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002409
type: Class
subclass of: myeloid dendritic cell chemotaxis

plasmacytoid dendritic cell chemotaxis
IAO_0000115: The movement of a plasmacytoid dendritic cell in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002410
type: Class
subclass of: dendritic cell chemotaxis

T cell tolerance induction to tumor cell
IAO_0000115: A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor.
has OBO namespace: biological_process
id: GO:0002411
type: Class
subclass of: tolerance induction to tumor cell
subclass of: T cell mediated immune response to tumor cell
subclass of: peripheral T cell tolerance induction

antigen transcytosis by M cells in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.
has exact synonym: antigen transcytosis by M cells in MALT
has exact synonym: antigen transport by M cells in MALT
has exact synonym: antigen transport by M cells in mucosal-associated lymphoid tissue
has OBO namespace: biological_process
id: GO:0002412
type: Class
subclass of: GO_0045056
subclass of: Restriction
  on property: part_of
  some values from: antigen sampling by M cells in mucosal-associated lymphoid tissue

tolerance induction to tumor cell
IAO_0000115: A process of tolerance induction which leads to immunological tolerance of a tumor.
has OBO namespace: biological_process
id: GO:0002413
type: Class
subclass of: immune response to tumor cell
subclass of: peripheral tolerance induction

immunoglobulin transcytosis in epithelial cells
IAO_0000115: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.
has OBO namespace: biological_process
id: GO:0002414
type: Class
subclass of: GO_0045056

immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
IAO_0000115: The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
has exact synonym: antibody transcytosis mediated by pIgR
has exact synonym: immunoglobulin transcytosis mediated by pIgR
has OBO namespace: biological_process
id: GO:0002415
type: Class
subclass of: immunoglobulin transcytosis in epithelial cells
subclass of: Restriction
  on property: part_of
  some values from: immune response in mucosal-associated lymphoid tissue

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
IAO_0000115: The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
has exact synonym: IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
has exact synonym: IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor
has OBO namespace: biological_process
id: GO:0002416
type: Class
subclass of: immunoglobulin transcytosis in epithelial cells

B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
IAO_0000115: B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor.
has exact synonym: B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
has exact synonym: B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen
has exact synonym: B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
has OBO namespace: biological_process
id: GO:0002417
type: Class
subclass of: B cell antigen processing and presentation
subclass of: antigen processing and presentation following receptor mediated endocytosis

immune response to tumor cell
IAO_0000115: An immune system process that functions in the response of an organism to a tumor cell.
has OBO namespace: biological_process
id: GO:0002418
type: Class
subclass of: response to tumor cell
subclass of: GO_0006955

T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: T lymphocyte mediated cytotoxicity directed against tumor cell target
has exact synonym: T-cell mediated cytotoxicity directed against tumor cell target
has exact synonym: T-lymphocyte mediated cytotoxicity directed against tumor cell target
has OBO namespace: biological_process
id: GO:0002419
type: Class
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
subclass of: T cell mediated cytotoxicity
subclass of: T cell mediated immune response to tumor cell

natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: NK cell mediated cytotoxicity directed against tumor cell target
has OBO namespace: biological_process
id: GO:0002420
type: Class
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
subclass of: natural killer cell mediated immune response to tumor cell
subclass of: GO_0042267

B cell antigen processing and presentation following pinocytosis
IAO_0000115: B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
has exact synonym: B lymphocyte antigen processing and presentation following pinocytosis
has exact synonym: B-cell antigen processing and presentation following pinocytosis
has exact synonym: B-lymphocyte antigen processing and presentation following pinocytosis
has OBO namespace: biological_process
id: GO:0002421
type: Class
subclass of: B cell antigen processing and presentation
subclass of: antigen processing and presentation following pinocytosis

immune response in urogenital tract
IAO_0000115: An immune response taking place in the urogenital tract. The urogenital tract.
has OBO namespace: biological_process
id: GO:0002422
type: Class
subclass of: mucosal immune response

natural killer cell mediated immune response to tumor cell
IAO_0000115: An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell.
has OBO namespace: biological_process
id: GO:0002423
type: Class
subclass of: natural killer cell mediated immunity
subclass of: immune response to tumor cell

T cell mediated immune response to tumor cell
IAO_0000115: An immune response mediated by a T cell triggered in response to the presence of a tumor cell.
has OBO namespace: biological_process
id: GO:0002424
type: Class
comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
subclass of: immune response to tumor cell
subclass of: T cell mediated immunity

tolerance induction in urogenital tract
IAO_0000115: Tolerance induction taking place in the urogenital tract.
has OBO namespace: biological_process
id: GO:0002425
type: Class
subclass of: immune response in urogenital tract
subclass of: mucosal tolerance induction

immunoglobulin production in mucosal tissue
IAO_0000115: The synthesis and release of immunoglobulin in the mucosal tissue.
has exact synonym: antibody production in mucosal tissue
has OBO namespace: biological_process
id: GO:0002426
type: Class
subclass of: immunoglobulin production involved in immunoglobulin mediated immune response
subclass of: Restriction
  on property: part_of
  some values from: mucosal immune response

mucosal tolerance induction
IAO_0000115: Tolerance induction taking place in the mucosal tissues.
has OBO namespace: biological_process
id: GO:0002427
type: Class
subclass of: mucosal immune response
subclass of: tolerance induction to nonself antigen

antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family.
has exact synonym: peptide antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002428
type: Class
subclass of: antigen processing and presentation via MHC class Ib
subclass of: GO_0048002

immune response-activating cell surface receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.
has exact synonym: activation of immune response by cell surface receptor signaling pathway
has exact synonym: immune response-activating cell surface receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002429
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune response-activating signal transduction
subclass of: immune response-regulating cell surface receptor signaling pathway

complement receptor mediated signaling pathway
IAO_0000115: A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
has broad synonym: immune response-regulating cell surface receptor signalling pathway
has exact synonym: complement receptor mediated signalling pathway
has OBO namespace: biological_process
id: GO:0002430
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune response-activating cell surface receptor signaling pathway

Fc receptor mediated stimulatory signaling pathway
IAO_0000115: A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
has exact synonym: Fc receptor mediated stimulatory signalling pathway
has exact synonym: Fc-receptor mediated stimulatory signaling pathway
has OBO namespace: biological_process
id: GO:0002431
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune response-activating cell surface receptor signaling pathway

granuloma formation
IAO_0000115: The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.
has OBO namespace: biological_process
id: GO:0002432
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune effector process
subclass of: Restriction
  on property: part_of
  some values from: chronic inflammatory response

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
IAO_0000115: An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
has exact synonym: immune response-regulating cell surface receptor signalling pathway involved in phagocytosis
has exact synonym: phagocytosis triggered by activation of immune response cell surface activating receptor
has OBO namespace: biological_process
id: GO:0002433
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune effector process
subclass of: immune response-regulating cell surface receptor signaling pathway
subclass of: Restriction
  on property: part_of
  some values from: GO_0006909

immune complex clearance
IAO_0000115: A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.
has OBO namespace: biological_process
id: GO:0002434
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune effector process

immune complex clearance by erythrocytes
IAO_0000115: The process of immune complex clearance by erythrocytes.
has exact synonym: immune complex clearance by RBCs
has exact synonym: immune complex clearance by red blood cells
has OBO namespace: biological_process
id: GO:0002435
type: Class
subclass of: immune complex clearance

immune complex clearance by monocytes and macrophages
IAO_0000115: The process of immune complex clearance by monocytes or macrophages.
has OBO namespace: biological_process
id: GO:0002436
type: Class
subclass of: immune complex clearance

inflammatory response to antigenic stimulus
IAO_0000115: An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
has OBO namespace: biological_process
id: GO:0002437
type: Class
subclass of: GO_0006954
subclass of: GO_0006955

acute inflammatory response to antigenic stimulus
IAO_0000115: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
has OBO namespace: biological_process
id: GO:0002438
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: inflammatory response to antigenic stimulus
subclass of: acute inflammatory response

chronic inflammatory response to antigenic stimulus
IAO_0000115: A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.
has OBO namespace: biological_process
id: GO:0002439
type: Class
subclass of: inflammatory response to antigenic stimulus
subclass of: chronic inflammatory response

production of molecular mediator of immune response
IAO_0000115: The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
has OBO namespace: biological_process
has related synonym: production of cellular mediator of immune response
id: GO:0002440
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune system process

histamine secretion involved in inflammatory response
IAO_0000115: The regulated release of histamine by a cell or group of cells as part of an inflammatory response.
has broad synonym: histamine secretion involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002441
type: Class
subclass of: histamine secretion
subclass of: GO_0046879
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954
subclass of: Restriction
  on property: part_of
  some values from: histamine production involved in inflammatory response

serotonin secretion involved in inflammatory response
IAO_0000115: The regulated release of serotonin by a cell or group of cells as part of an inflammatory response.
has broad synonym: serotonin secretion involved in acute inflammatory response
has OBO namespace: biological_process
has related synonym: serotonin release involved in inflammatory response
id: GO:0002442
type: Class
subclass of: serotonin secretion
subclass of: Restriction
  on property: part_of
  some values from: serotonin production involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a leukocyte.
has alternative id: GO:0019723
has alternative id: GO:0042087
has exact synonym: immune cell effector process
has exact synonym: immune cell mediated immunity
has exact synonym: leucocyte immune effector process
has exact synonym: leucocyte mediated immunity
has exact synonym: leukocyte immune effector process
has OBO namespace: biological_process
has related synonym: cell-mediated immune response
has related synonym: cellular immune response
id: GO:0002443
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune effector process

myeloid leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a myeloid leukocyte.
has exact synonym: myeloid leucocyte immune effector process
has exact synonym: myeloid leucocyte mediated immunity
has exact synonym: myeloid leukocyte immune effector process
has OBO namespace: biological_process
id: GO:0002444
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: leukocyte mediated immunity

type II hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
has db xref: Wikipedia:Type_II_hypersensitivity
has OBO namespace: biological_process
id: GO:0002445
type: Class
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: GO_0016064

neutrophil mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a neutrophil.
has OBO namespace: biological_process
id: GO:0002446
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: myeloid leukocyte mediated immunity

eosinophil mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by an eosinophil.
has OBO namespace: biological_process
id: GO:0002447
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: myeloid leukocyte mediated immunity

mast cell mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a mast cell.
has OBO namespace: biological_process
id: GO:0002448
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: myeloid leukocyte mediated immunity

lymphocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a lymphocyte.
has broad synonym: cell-mediated immunity
has broad synonym: cellular immune response
has OBO namespace: biological_process
id: GO:0002449
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: leukocyte mediated immunity

B cell antigen processing and presentation
IAO_0000115: The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has exact synonym: B lymphocyte antigen processing and presentation
has exact synonym: B-cell antigen processing and presentation
has exact synonym: B-lymphocyte antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002450
type: Class
subclass of: GO_0019882
subclass of: Restriction
  on property: part_of
  some values from: GO_0019724

peripheral B cell tolerance induction
IAO_0000115: Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.
has exact synonym: peripheral B lymphocyte tolerance induction
has exact synonym: peripheral B-cell tolerance induction
has exact synonym: peripheral B-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002451
type: Class
subclass of: peripheral tolerance induction
subclass of: B cell tolerance induction
subclass of: GO_0019724

B cell receptor editing
IAO_0000115: The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.
has exact synonym: B lymphocyte receptor editing
has exact synonym: B-cell receptor editing
has exact synonym: B-lymphocyte receptor editing
has OBO namespace: biological_process
id: GO:0002452
type: Class
subclass of: GO_0016447

peripheral B cell anergy
IAO_0000115: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells.
has exact synonym: peripheral B lymphocyte anergy
has exact synonym: peripheral B-cell anergy
has exact synonym: peripheral B-lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002453
type: Class
subclass of: B cell anergy
subclass of: Restriction
  on property: part_of
  some values from: peripheral B cell tolerance induction

peripheral B cell deletion
IAO_0000115: The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection.
has exact synonym: peripheral B lymphocyte deletion
has exact synonym: peripheral B-cell deletion
has exact synonym: peripheral B-lymphocyte deletion
has OBO namespace: biological_process
id: GO:0002454
type: Class
subclass of: B cell deletion
subclass of: Restriction
  on property: part_of
  some values from: peripheral B cell tolerance induction

humoral immune response mediated by circulating immunoglobulin
IAO_0000115: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
has exact synonym: circulating antibody mediated immune response
has exact synonym: circulating immunoglobulin mediated immune response
has exact synonym: humoral immune response mediated by circulating antibody
has OBO namespace: biological_process
has related synonym: humoral defence mechanism
id: GO:0002455
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0006959
subclass of: GO_0016064

T cell mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a T cell.
has broad synonym: cell-mediated immunity
has broad synonym: cellular immune response
has exact synonym: T lymphocyte mediated immunity
has exact synonym: T-cell mediated immunity
has exact synonym: T-lymphocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002456
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: lymphocyte mediated immunity
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

T cell antigen processing and presentation
IAO_0000115: The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has exact synonym: T lymphocyte antigen processing and presentation
has exact synonym: T-cell antigen processing and presentation
has exact synonym: T-lymphocyte antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002457
type: Class
subclass of: GO_0019882
subclass of: Restriction
  on property: part_of
  some values from: T cell mediated immunity

peripheral T cell tolerance induction
IAO_0000115: Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus.
has exact synonym: peripheral T lymphocyte tolerance induction
has exact synonym: peripheral T-cell tolerance induction
has exact synonym: peripheral T-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002458
type: Class
subclass of: T cell mediated immunity
subclass of: peripheral tolerance induction
subclass of: T cell tolerance induction

adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
IAO_0000115: An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae).
has exact synonym: adaptive immune response based on somatic recombination of VLR built from LRR domains
has exact synonym: adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains
has exact synonym: adaptive immune response in jawless fish
has OBO namespace: biological_process
id: GO:0002459
type: Class
subclass of: adaptive immune response

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
has OBO namespace: biological_process
id: GO:0002460
type: Class
subclass of: adaptive immune response

tolerance induction dependent upon immune response
IAO_0000115: Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.
has exact synonym: immune response-dependent tolerance induction
has OBO namespace: biological_process
id: GO:0002461
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: tolerance induction

tolerance induction to nonself antigen
IAO_0000115: Tolerance induction in response to nonself antigens.
has OBO namespace: biological_process
id: GO:0002462
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: tolerance induction dependent upon immune response

central tolerance induction to nonself antigen
IAO_0000115: Tolerance induction to nonself antigens in the central lymphoid organs.
has OBO namespace: biological_process
id: GO:0002463
type: Class
subclass of: tolerance induction to nonself antigen
subclass of: central tolerance induction

peripheral tolerance induction to nonself antigen
IAO_0000115: Tolerance induction to nonself antigens in the periphery.
has OBO namespace: biological_process
id: GO:0002464
type: Class
subclass of: tolerance induction to nonself antigen
subclass of: peripheral tolerance induction

peripheral tolerance induction
IAO_0000115: Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
has OBO namespace: biological_process
id: GO:0002465
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: tolerance induction dependent upon immune response

peripheral tolerance induction to self antigen
IAO_0000115: Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
has OBO namespace: biological_process
id: GO:0002466
type: Class
subclass of: peripheral tolerance induction
subclass of: tolerance induction to self antigen

germinal center formation
IAO_0000115: The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.
has OBO namespace: biological_process
id: GO:0002467
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

dendritic cell antigen processing and presentation
IAO_0000115: The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002468
type: Class
subclass of: GO_0019882

myeloid dendritic cell antigen processing and presentation
IAO_0000115: The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002469
type: Class
subclass of: dendritic cell antigen processing and presentation

plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002470
type: Class
subclass of: dendritic cell antigen processing and presentation

monocyte antigen processing and presentation
IAO_0000115: The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002471
type: Class
subclass of: GO_0019882

macrophage antigen processing and presentation
IAO_0000115: The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002472
type: Class
subclass of: GO_0019882

non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils.
has OBO namespace: biological_process
id: GO:0002473
type: Class
subclass of: GO_0019882

antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
has db xref: Reactome:REACT_110097
has db xref: Reactome:REACT_114442
has db xref: Reactome:REACT_75820
has db xref: Reactome:REACT_77569
has db xref: Reactome:REACT_83138
has db xref: Reactome:REACT_84092
has db xref: Reactome:REACT_86224
has db xref: Reactome:REACT_88020
has db xref: Reactome:REACT_90151
has db xref: Reactome:REACT_94042
has exact synonym: peptide antigen processing and presentation via MHC class I
has OBO namespace: biological_process
id: GO:0002474
type: Class
subclass of: GO_0048002

antigen processing and presentation via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.
has OBO namespace: biological_process
id: GO:0002475
type: Class
subclass of: GO_0019882

antigen processing and presentation of endogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002476
type: Class
subclass of: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: antigen processing and presentation of endogenous peptide antigen

antigen processing and presentation of exogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002477
type: Class
subclass of: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: antigen processing and presentation of exogenous peptide antigen
subclass of: Restriction
  on property: part_of
  some values from: GO_0042638

antigen processing and presentation of exogenous peptide antigen
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.
has exact synonym: exogenous peptide antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002478
type: Class
subclass of: GO_0019884
subclass of: GO_0048002
subclass of: Restriction
  on property: part_of
  some values from: GO_0042638

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
has broad synonym: cross presentation
has broad synonym: cross-presentation
has db xref: Reactome:REACT_111056
has db xref: Reactome:REACT_111174
has db xref: Reactome:REACT_111178
has exact synonym: TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I
has exact synonym: TAP-dependent exogenous peptide antigen processing and presentation via MHC class I
has exact synonym: exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent
has OBO namespace: biological_process
id: GO:0002479
type: Class
subclass of: GO_0042590

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.
has broad synonym: cross presentation
has broad synonym: cross-presentation
has db xref: Reactome:REACT_111168
has exact synonym: TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I
has exact synonym: TAP-independent exogenous peptide antigen processing and presentation via MHC class I
has exact synonym: exogenous peptide antigen processing and presentation via MHC class I, TAP-independent
has OBO namespace: biological_process
id: GO:0002480
type: Class
subclass of: GO_0042590

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib
has exact synonym: TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent
has OBO namespace: biological_process
id: GO:0002481
type: Class
subclass of: antigen processing and presentation of exogenous peptide antigen via MHC class Ib

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib
has exact synonym: TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent
has OBO namespace: biological_process
id: GO:0002482
type: Class
subclass of: antigen processing and presentation of exogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.
has exact synonym: endogenous peptide antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002483
type: Class
subclass of: GO_0019883
subclass of: GO_0048002

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway
has OBO namespace: biological_process
id: GO:0002484
type: Class
subclass of: GO_0019885

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.
has exact synonym: TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
has exact synonym: TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent
has OBO namespace: biological_process
id: GO:0002485
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.
has exact synonym: TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
has exact synonym: TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent
has OBO namespace: biological_process
id: GO:0002486
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway
has OBO namespace: biological_process
id: GO:0002487
type: Class
subclass of: GO_0019885

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway
has OBO namespace: biological_process
id: GO:0002488
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
has exact synonym: TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent
has OBO namespace: biological_process
id: GO:0002489
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
has exact synonym: TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent
has OBO namespace: biological_process
id: GO:0002490
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class II
has OBO namespace: biological_process
id: GO:0002491
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen
subclass of: antigen processing and presentation of peptide antigen via MHC class II

peptide antigen assembly with MHC class Ib protein complex
IAO_0000115: The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has OBO namespace: biological_process
id: GO:0002492
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: Restriction
  on property: part_of
  some values from: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: Restriction
  on property: part_of
  some values from: MHC class Ib protein complex assembly

lipid antigen assembly with MHC class Ib protein complex
IAO_0000115: The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family.
has OBO namespace: biological_process
id: GO:0002493
type: Class
subclass of: GO_0065005
subclass of: Restriction
  on property: part_of
  some values from: GO_0048003
subclass of: Restriction
  on property: part_of
  some values from: MHC class Ib protein complex assembly

lipid antigen transport
IAO_0000115: The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has OBO namespace: biological_process
id: GO:0002494
type: Class
subclass of: GO_0006869
subclass of: Restriction
  on property: part_of
  some values from: GO_0048003

antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
has exact synonym: peptide antigen processing and presentation via MHC class II
has OBO namespace: biological_process
id: GO:0002495
type: Class
subclass of: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: GO_0048002

proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002496
type: Class
subclass of: GO_0051603
subclass of: Restriction
  on property: part_of
  some values from: GO_0048002

proteasomal proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002497
type: Class
subclass of: proteolysis associated with antigen processing and presentation
subclass of: GO_0043161

proteolysis within endoplasmic reticulum associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation.
has exact synonym: ER proteolysis associated with antigen processing and presentation
has exact synonym: endoplasmic reticulum proteolysis associated with antigen processing and presentation
has exact synonym: proteolysis within ER associated with antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002498
type: Class
subclass of: proteolysis associated with antigen processing and presentation

proteolysis within endosome associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation.
has exact synonym: endosomal proteolysis associated with antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002499
type: Class
subclass of: proteolysis associated with antigen processing and presentation

proteolysis within lysosome associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation.
has exact synonym: lysosomal proteolysis associated with antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002500
type: Class
subclass of: proteolysis associated with antigen processing and presentation
subclass of: GO_0007039

peptide antigen assembly with MHC protein complex
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC protein complex.
has OBO namespace: biological_process
id: GO:0002501
type: Class
subclass of: GO_0043623
subclass of: Restriction
  on property: part_of
  some values from: MHC protein complex assembly
subclass of: Restriction
  on property: part_of
  some values from: GO_0048002

peptide antigen assembly with MHC class I protein complex
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.
has OBO namespace: biological_process
id: GO:0002502
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: Restriction
  on property: part_of
  some values from: MHC class I protein complex assembly
subclass of: Restriction
  on property: part_of
  some values from: antigen processing and presentation of peptide antigen via MHC class I

peptide antigen assembly with MHC class II protein complex
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC class II protein complex.
has OBO namespace: biological_process
id: GO:0002503
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: Restriction
  on property: part_of
  some values from: antigen processing and presentation of peptide antigen via MHC class II
subclass of: Restriction
  on property: part_of
  some values from: MHC class II protein complex assembly

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.
has exact synonym: peptide or polysaccharide antigen processing and presentation of via MHC class II
has OBO namespace: biological_process
id: GO:0002504
type: Class
subclass of: GO_0019882

antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex.
has exact synonym: polysaccharide antigen processing and presentation via MHC class II
has OBO namespace: biological_process
id: GO:0002505
type: Class
subclass of: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

polysaccharide assembly with MHC class II protein complex
IAO_0000115: The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex.
has OBO namespace: biological_process
id: GO:0002506
type: Class
subclass of: GO_0065006
subclass of: Restriction
  on property: part_of
  some values from: antigen processing and presentation of polysaccharide antigen via MHC class II
subclass of: Restriction
  on property: part_of
  some values from: MHC class II protein complex assembly

tolerance induction
IAO_0000115: A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
has OBO namespace: biological_process
id: GO:0002507
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: immune system process
subclass of: Restriction
  on property: part_of
  some values from: immune system development

central tolerance induction
IAO_0000115: Tolerance induction in the central lymphoid organs: the thymus and bone marrow.
has OBO namespace: biological_process
id: GO:0002508
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: tolerance induction

central tolerance induction to self antigen
IAO_0000115: Tolerance induction in the central lymphoid organs directed at self antigens.
has OBO namespace: biological_process
id: GO:0002509
type: Class
subclass of: central tolerance induction
subclass of: tolerance induction to self antigen

central B cell tolerance induction
IAO_0000115: Tolerance induction of B cells in the bone marrow.
has exact synonym: central B lymphocyte tolerance induction
has exact synonym: central B-cell tolerance induction
has exact synonym: central B-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002510
type: Class
subclass of: central tolerance induction
subclass of: B cell tolerance induction

central B cell receptor editing
IAO_0000115: Receptor editing occurring in B cells in the bone marrow.
has exact synonym: central B lymphocyte receptor editing
has exact synonym: central B-cell receptor editing
has exact synonym: central B-lymphocyte receptor editing
has OBO namespace: biological_process
id: GO:0002511
type: Class
subclass of: B cell receptor editing

central T cell tolerance induction
IAO_0000115: Tolerance induction of T cells in the thymus.
has exact synonym: central T lymphocyte tolerance induction
has exact synonym: central T-cell tolerance induction
has exact synonym: central T-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002512
type: Class
subclass of: central tolerance induction
subclass of: T cell tolerance induction

tolerance induction to self antigen
IAO_0000115: Tolerance induction directed at self antigens.
has OBO namespace: biological_process
id: GO:0002513
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: tolerance induction

B cell tolerance induction
IAO_0000115: A process involving any mechanism for tolerance induction in B cells.
has exact synonym: B lymphocyte tolerance induction
has exact synonym: B-cell tolerance induction
has exact synonym: B-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002514
type: Class
subclass of: tolerance induction

B cell anergy
IAO_0000115: Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction.
has exact synonym: B lymphocyte anergy
has exact synonym: B-cell anergy
has exact synonym: B-lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002515
type: Class
subclass of: lymphocyte anergy
subclass of: B cell tolerance induction

B cell deletion
IAO_0000115: The apoptotic death of B cells which is part of B cell tolerance induction.
has exact synonym: B lymphocyte deletion
has exact synonym: B-cell deletion
has exact synonym: B-lymphocyte deletion
has OBO namespace: biological_process
id: GO:0002516
type: Class
subclass of: B cell apoptotic process
subclass of: Restriction
  on property: part_of
  some values from: B cell tolerance induction

T cell tolerance induction
IAO_0000115: A process involving any mechanism for tolerance induction in T cells.
has exact synonym: T lymphocyte tolerance induction
has exact synonym: T-cell tolerance induction
has exact synonym: T-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002517
type: Class
subclass of: tolerance induction

lymphocyte chemotaxis across high endothelial venule
IAO_0000115: The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002518
type: Class
subclass of: GO_0048247

natural killer cell tolerance induction
IAO_0000115: Tolerance induction of natural killer cells.
has exact synonym: NK cell tolerance induction
has OBO namespace: biological_process
id: GO:0002519
type: Class
subclass of: tolerance induction

immune system development
IAO_0000115: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
has OBO namespace: biological_process
id: GO:0002520
type: Class
subclass of: immune system process
subclass of: GO_0048731

leukocyte differentiation
IAO_0000115: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
has exact synonym: immune cell differentiation
has exact synonym: leucocyte differentiation
has OBO namespace: biological_process
id: GO:0002521
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0030097

leukocyte migration involved in immune response
IAO_0000115: The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.
has exact synonym: immune cell migration during immune response
has exact synonym: immune cell trafficking during immune response
has exact synonym: leucocyte migration during immune response
has exact synonym: leucocyte trafficking during immune response
has exact synonym: leukocyte trafficking during immune response
has OBO namespace: biological_process
id: GO:0002522
type: Class
subclass of: immune effector process
subclass of: GO_0050900
subclass of: Restriction
  on property: part_of
  some values from: GO_0006955

leukocyte migration involved in inflammatory response
IAO_0000115: The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
has OBO namespace: biological_process
has related synonym: immune cell migration during inflammatory response
has related synonym: immune cell trafficking during inflammatory response
has related synonym: leucocyte migration during inflammatory response
has related synonym: leucocyte trafficking during inflammatory response
has related synonym: leukocyte migration during inflammatory response
has related synonym: leukocyte trafficking during inflammatory response
id: GO:0002523
type: Class
subclass of: GO_0050900
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

hypersensitivity
IAO_0000115: An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
has db xref: Wikipedia:Hypersensitivity
has OBO namespace: biological_process
has related synonym: hypersensitivity response
id: GO:0002524
type: Class
subclass of: acute inflammatory response to antigenic stimulus

acute inflammatory response to non-antigenic stimulus
IAO_0000115: An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma.
has OBO namespace: biological_process
id: GO:0002525
type: Class
subclass of: acute inflammatory response

acute inflammatory response
IAO_0000115: Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
has OBO namespace: biological_process
id: GO:0002526
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0006954

vasodilation involved in acute inflammatory response
IAO_0000115: An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response.
has OBO namespace: biological_process
has related synonym: vasodilation during acute inflammatory response
id: GO:0002527
type: Class
subclass of: GO_0042311
subclass of: Restriction
  on property: part_of
  some values from: acute inflammatory response

regulation of vascular permeability involved in acute inflammatory response
IAO_0000115: Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.
has OBO namespace: biological_process
has related synonym: regulation of vascular permeability during acute inflammatory response
id: GO:0002528
type: Class
subclass of: GO_0043114
subclass of: Restriction
  on property: part_of
  some values from: acute inflammatory response

regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has OBO namespace: biological_process
id: GO:0002529
type: Class
subclass of: regulation of kinin cascade
subclass of: Restriction
  on property: RO_0002211
  some values from: plasma kallikrein-kinin cascade

regulation of systemic arterial blood pressure involved in acute-phase response
IAO_0000115: Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.
has OBO namespace: biological_process
has related synonym: blood pressure regulation during acute phase response
has related synonym: regulation of systemic arterial blood pressure during acute phase response
id: GO:0002530
type: Class
subclass of: regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: GO_0006953

regulation of heart contraction involved in acute-phase response
IAO_0000115: Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.
has OBO namespace: biological_process
has related synonym: regulation of cardiac contraction during acute phase response
has related synonym: regulation of heart contraction during acute phase response
id: GO:0002531
type: Class
subclass of: GO_0008016
subclass of: Restriction
  on property: part_of
  some values from: GO_0006953

production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: production of molecular mediator involved in acute inflammatory response
has OBO namespace: biological_process
has related synonym: production of cellular mediator of acute inflammation
id: GO:0002532
type: Class
subclass of: GO_0044707
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

lysosomal enzyme secretion involved in inflammatory response
IAO_0000115: The regulated release of lysosomal enzymes by a cell or group of cells as part of an inflammatory response.
has broad synonym: secretion of lysosomal enzymes involved in acute inflammatory response
has exact synonym: secretion of lysosomal enzymes involved in inflammatory response
has OBO namespace: biological_process
has related synonym: lysosomal enzyme secretion involved in acute inflammatory response
id: GO:0002533
type: Class
subclass of: GO_0033299
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954
subclass of: Restriction
  on property: part_of
  some values from: lysosomal enzyme production involved in inflammatory response

cytokine production involved in inflammatory response
IAO_0000115: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: cytokine production involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002534
type: Class
subclass of: cytokine production
subclass of: production of molecular mediator involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

platelet activating factor secretion involved in inflammatory response
IAO_0000115: The regulated release of platelet activating factor by a cell or group of cells as part of an inflammatory response.
has broad synonym: platelet activating factor secretion involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002535
type: Class
subclass of: platelet activating factor secretion
subclass of: Restriction
  on property: part_of
  some values from: platelet activating factor production involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

respiratory burst involved in inflammatory response
IAO_0000115: A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.
has broad synonym: oxidative burst during acute inflammatory response
has broad synonym: production of reactive oxygen species during acute inflammatory response
has broad synonym: respiratory burst involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002536
type: Class
subclass of: production of molecular mediator involved in inflammatory response
subclass of: respiratory burst involved in defense response
subclass of: Restriction
  on property: part_of
  some values from: GO_0006954

nitric oxide production involved in inflammatory response
IAO_0000115: The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: nitric oxide production involved in acute inflammatory response
has broad synonym: production of nitric oxide involved in acute inflammatory response
has exact synonym: production of nitric oxide involved in inflammatory response
has OBO namespace: biological_process
id: GO:0002537
type: Class
subclass of: production of molecular mediator involved in inflammatory response

arachidonic acid metabolite production involved in inflammatory response
IAO_0000115: The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels.
has broad synonym: arachidonic acid metabolite production involved in acute inflammatory response
has broad synonym: production of arachidonic acid metabolites involved in acute inflammatory response
has exact synonym: production of arachidonic acid metabolites involved in inflammatory response
has OBO namespace: biological_process
id: GO:0002538
type: Class
subclass of: production of molecular mediator involved in inflammatory response

prostaglandin production involved in inflammatory response
IAO_0000115: The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: prostaglandin production involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002539
type: Class
subclass of: arachidonic acid metabolite production involved in inflammatory response

leukotriene production involved in inflammatory response
IAO_0000115: The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has broad synonym: leukotriene production involved in acute inflammatory response
has OBO namespace: biological_process
id: GO:0002540
type: Class
subclass of: arachidonic acid metabolite production involved in inflammatory response

activation of plasma proteins involved in acute inflammatory response
IAO_0000115: Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
has OBO namespace: biological_process
id: GO:0002541
type: Class
subclass of: GO_0016485
subclass of: Restriction
  on property: part_of
  some values from: acute inflammatory response

Factor XII activation
IAO_0000115: Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
has exact synonym: Hageman factor activation
has OBO namespace: biological_process
id: GO:0002542
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0010954
subclass of: Restriction
  on property: part_of
  some values from: plasma kallikrein-kinin cascade
subclass of: Restriction
  on property: RO_0002213
  some values from: activation of plasma proteins involved in acute inflammatory response

activation of blood coagulation via clotting cascade
IAO_0000115: Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.
has exact synonym: activation of clotting cascade
has OBO namespace: biological_process
id: GO:0002543
type: Class
subclass of: GO_0030194
subclass of: Restriction
  on property: part_of
  some values from: acute inflammatory response

chronic inflammatory response
IAO_0000115: Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.
has OBO namespace: biological_process
id: GO:0002544
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: GO_0006954

chronic inflammatory response to non-antigenic stimulus
IAO_0000115: A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma.
has OBO namespace: biological_process
id: GO:0002545
type: Class
subclass of: chronic inflammatory response

negative regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: down regulation of tissue kallikrein-kinin cascade
has exact synonym: down-regulation of tissue kallikrein-kinin cascade
has exact synonym: downregulation of tissue kallikrein-kinin cascade
has exact synonym: negative regulation of glandular kallikrein-kinin cascade
has narrow synonym: inhibition of tissue kallikrein-kinin cascade
has OBO namespace: biological_process
id: GO:0002546
type: Class
subclass of: negative regulation of kinin cascade
subclass of: regulation of tissue kallikrein-kinin cascade
subclass of: Restriction
  on property: RO_0002212
  some values from: tissue kallikrein-kinin cascade

positive regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: positive regulation of glandular kallikrein-kinin cascade
has exact synonym: up regulation of tissue kallikrein-kinin cascade
has exact synonym: up-regulation of tissue kallikrein-kinin cascade
has exact synonym: upregulation of tissue kallikrein-kinin cascade
has narrow synonym: activation of tissue kallikrein-kinin cascade
has narrow synonym: stimulation of tissue kallikrein-kinin cascade
has OBO namespace: biological_process
id: GO:0002547
type: Class
subclass of: positive regulation of kinin cascade
subclass of: regulation of tissue kallikrein-kinin cascade
subclass of: Restriction
  on property: RO_0002213
  some values from: tissue kallikrein-kinin cascade

monocyte chemotaxis
IAO_0000115: The movement of a monocyte in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002548
type: Class
subclass of: GO_0030595

negative regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has exact synonym: down regulation of plasma kallikrein-kinin cascade
has exact synonym: down-regulation of plasma kallikrein-kinin cascade
has exact synonym: downregulation of plasma kallikrein-kinin cascade
has narrow synonym: inhibition of plasma kallikrein-kinin cascade
has OBO namespace: biological_process
id: GO:0002549
type: Class
subclass of: negative regulation of kinin cascade
subclass of: regulation of plasma kallikrein-kinin cascade
subclass of: Restriction
  on property: RO_0002212
  some values from: plasma kallikrein-kinin cascade

positive regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has exact synonym: up regulation of plasma kallikrein-kinin cascade
has exact synonym: up-regulation of plasma kallikrein-kinin cascade
has exact synonym: upregulation of plasma kallikrein-kinin cascade
has narrow synonym: activation of plasma kallikrein-kinin cascade
has narrow synonym: stimulation of plasma kallikrein-kinin cascade
has OBO namespace: biological_process
id: GO:0002550
type: Class
subclass of: positive regulation of kinin cascade
subclass of: regulation of plasma kallikrein-kinin cascade
subclass of: Restriction
  on property: RO_0002213
  some values from: plasma kallikrein-kinin cascade

mast cell chemotaxis
IAO_0000115: The movement of a mast cell in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002551
type: Class
subclass of: GO_0030595

serotonin secretion by mast cell
IAO_0000115: The regulated release of serotonin by a mast cell or group of mast cells.
has OBO namespace: biological_process
has related synonym: serotonin release by mast cell
id: GO:0002552
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: GO_0043303

histamine secretion by mast cell
IAO_0000115: The regulated release of histamine by a mast cell or group of mast cells.
has OBO namespace: biological_process
id: GO:0002553
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: GO_0043303

serotonin secretion by platelet
IAO_0000115: The regulated release of serotonin by a platelet or group of platelets.
has OBO namespace: biological_process
has related synonym: serotonin release by platelet
id: GO:0002554
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: platelet degranulation

histamine secretion by platelet
IAO_0000115: The regulated release of histamine by a platelet or group of platelets.
has OBO namespace: biological_process
id: GO:0002555
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: platelet degranulation

serotonin secretion by basophil
IAO_0000115: The regulated release of serotonin by a basophil or group of basophils.
has OBO namespace: biological_process
has related synonym: serotonin release by basophil
id: GO:0002556
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: basophil degranulation

histamine secretion by basophil
IAO_0000115: The regulated release of histamine by a basophil or group of basophils.
has OBO namespace: biological_process
id: GO:0002557
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: Restriction
  on property: part_of
  some values from: basophil degranulation

type I hypersensitivity mediated by mast cells
IAO_0000115: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
has OBO namespace: biological_process
id: GO:0002558
type: Class
subclass of: mast cell mediated immunity
subclass of: GO_0016068

type I hypersensitivity mediated by basophils
IAO_0000115: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
has OBO namespace: biological_process
id: GO:0002559
type: Class
subclass of: basophil mediated immunity
subclass of: GO_0016068

basophil mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a basophil.
has OBO namespace: biological_process
id: GO:0002560
type: Class
subclass of: myeloid leukocyte mediated immunity

basophil degranulation
IAO_0000115: The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil.
has OBO namespace: biological_process
id: GO:0002561
type: Class
subclass of: basophil activation involved in immune response
subclass of: GO_0043299
subclass of: Restriction
  on property: part_of
  some values from: basophil mediated immunity

somatic diversification of immune receptors via germline recombination within a single locus
IAO_0000115: The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.
has OBO namespace: biological_process
id: GO:0002562
type: Class
subclass of: somatic diversification of immune receptors
subclass of: GO_0016444

somatic diversification of immune receptors via alternate splicing
IAO_0000115: The process in which immune receptor genes are diversified through alternate splicing.
has OBO namespace: biological_process
id: GO:0002563
type: Class
subclass of: somatic diversification of immune receptors

alternate splicing of immunoglobulin genes
IAO_0000115: The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons.
has exact synonym: alternate splicing of antibody genes
has OBO namespace: biological_process
id: GO:0002564
type: Class
subclass of: somatic diversification of immune receptors via alternate splicing
subclass of: GO_0016445

somatic diversification of immune receptors via gene conversion
IAO_0000115: The process in which immune receptor genes are diversified through gene conversion.
has OBO namespace: biological_process
id: GO:0002565
type: Class
subclass of: somatic diversification of immune receptors
subclass of: GO_0016444

somatic diversification of immune receptors via somatic mutation
IAO_0000115: The process in which immune receptor genes are diversified through somatic mutation.
has OBO namespace: biological_process
id: GO:0002566
type: Class
subclass of: somatic diversification of immune receptors

somatic diversification of FREP-based immune receptors
IAO_0000115: The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails.
has OBO namespace: biological_process
id: GO:0002567
type: Class
comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species.
subclass of: somatic diversification of immune receptors

somatic diversification of T cell receptor genes
IAO_0000115: The somatic process that results in the generation of sequence diversity of T cell receptor genes.
has exact synonym: somatic diversification of TCR genes
has OBO namespace: biological_process
id: GO:0002568
type: Class
subclass of: somatic diversification of immune receptors
subclass of: Restriction
  on property: part_of
  some values from: GO_0030217

somatic diversification of immune receptors by N region addition
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene.
has OBO namespace: biological_process
id: GO:0002569
type: Class
subclass of: somatic diversification of immune receptors

somatic diversification of immunoglobulin genes by N region addition
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions.
has exact synonym: somatic diversification of antibody genes by N region addition
has OBO namespace: biological_process
id: GO:0002570
type: Class
subclass of: somatic diversification of immune receptors by N region addition
subclass of: GO_0016445
subclass of: Restriction
  on property: part_of
  some values from: GO_0016447

somatic diversification of T cell receptor genes by N region addition
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene.
has exact synonym: somatic diversification of TCR genes by N region addition
has OBO namespace: biological_process
id: GO:0002571
type: Class
subclass of: somatic diversification of T cell receptor genes
subclass of: somatic diversification of immune receptors by N region addition
subclass of: Restriction
  on property: part_of
  some values from: somatic recombination of T cell receptor gene segments

pro-T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.
has exact synonym: pro-T lymphocyte differentiation
has OBO namespace: biological_process
id: GO:0002572
type: Class
subclass of: lymphoid progenitor cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: GO_0030217

myeloid leukocyte differentiation
IAO_0000115: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
has exact synonym: myeloid leucocyte differentiation
has OBO namespace: biological_process
id: GO:0002573
type: Class
subclass of: leukocyte differentiation
subclass of: GO_0030099

thrombocyte differentiation
IAO_0000115: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
has OBO namespace: biological_process
id: GO:0002574
type: Class
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
subclass of: GO_0030099

basophil chemotaxis
IAO_0000115: The movement of a basophil in response to an external stimulus.
has OBO namespace: biological_process
id: GO:0002575
type: Class
subclass of: GO_0030595

platelet degranulation
IAO_0000115: The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
has db xref: Reactome:REACT_100828
has db xref: Reactome:REACT_102232
has db xref: Reactome:REACT_102739
has db xref: Reactome:REACT_102744
has db xref: Reactome:REACT_104057
has db xref: Reactome:REACT_104856
has db xref: Reactome:REACT_118371
has db xref: Reactome:REACT_29845
has db xref: Reactome:REACT_30497
has db xref: Reactome:REACT_31557
has db xref: Reactome:REACT_318
has db xref: Reactome:REACT_33703
has db xref: Reactome:REACT_80537
has db xref: Reactome:REACT_81075
has db xref: Reactome:REACT_81265
has db xref: Reactome:REACT_81408
has db xref: Reactome:REACT_87179
has db xref: Reactome:REACT_97581
has db xref: Reactome:REACT_99712
has exact synonym: platelet exocytosis
has OBO namespace: biological_process
id: GO:0002576
type: Class
subclass of: GO_0006887

regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002577
type: Class
subclass of: regulation of immune system process
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0019882

negative regulation of antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.
has exact synonym: down regulation of antigen processing and presentation
has exact synonym: down-regulation of antigen processing and presentation
has exact synonym: downregulation of antigen processing and presentation
has narrow synonym: inhibition of antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002578
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: negative regulation of immune system process
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0019882

positive regulation of antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.
has exact synonym: up regulation of antigen processing and presentation
has exact synonym: up-regulation of antigen processing and presentation
has exact synonym: upregulation of antigen processing and presentation
has narrow synonym: activation of antigen processing and presentation
has narrow synonym: stimulation of antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002579
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: positive regulation of immune system process
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0019882

regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
has OBO namespace: biological_process
id: GO:0002580
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
has narrow synonym: inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has OBO namespace: biological_process
id: GO:0002581
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002212
  some values from: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
has exact synonym: up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has narrow synonym: activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has narrow synonym: stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has OBO namespace: biological_process
id: GO:0002582
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002213
  some values from: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: regulation of peptide antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002583
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0048002

negative regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen
has exact synonym: downregulation of antigen processing and presentation of peptide antigen
has exact synonym: negative regulation of peptide antigen processing and presentation
has narrow synonym: inhibition of antigen processing and presentation of peptide antigen
has OBO namespace: biological_process
id: GO:0002584
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0048002

positive regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: positive regulation of peptide antigen processing and presentation
has exact synonym: up regulation of antigen processing and presentation of peptide antigen
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen
has exact synonym: upregulation of antigen processing and presentation of peptide antigen
has narrow synonym: activation of antigen processing and presentation of peptide antigen
has narrow synonym: stimulation of antigen processing and presentation of peptide antigen
has OBO namespace: biological_process
id: GO:0002585
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0048002

regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class II
has OBO namespace: biological_process
id: GO:0002586
type: Class
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: Restriction
  on property: RO_0002211
  some values from: antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class II
has narrow synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class II
has OBO namespace: biological_process
id: GO:0002587
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002212
  some values from: antigen processing and presentation of peptide antigen via MHC class II

positive regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class II
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class II
has narrow synonym: activation of antigen processing and presentation of peptide antigen via MHC class II
has narrow synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class II
has OBO namespace: biological_process
id: GO:0002588
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002213
  some values from: antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class I
has OBO namespace: biological_process
id: GO:0002589
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: Restriction
  on property: RO_0002211
  some values from: antigen processing and presentation of peptide antigen via MHC class I

negative regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class I
has narrow synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class I
has OBO namespace: biological_process
id: GO:0002590
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class I
subclass of: Restriction
  on property: RO_0002212
  some values from: antigen processing and presentation of peptide antigen via MHC class I

positive regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class I
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class I
has narrow synonym: activation of antigen processing and presentation of peptide antigen via MHC class I
has narrow synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class I
has OBO namespace: biological_process
id: GO:0002591
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class I
subclass of: Restriction
  on property: RO_0002213
  some values from: antigen processing and presentation of peptide antigen via MHC class I

regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has OBO namespace: biological_process
id: GO:0002592
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has exact synonym: down regulation of antigen processing and presentation via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation via MHC class Ib
has exact synonym: downregulation of antigen processing and presentation via MHC class Ib
has narrow synonym: inhibition of antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002593
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation via MHC class Ib
subclass of: Restriction
  on property: RO_0002212
  some values from: antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has exact synonym: up regulation of antigen processing and presentation via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation via MHC class Ib
has narrow synonym: activation of antigen processing and presentation via MHC class Ib
has narrow synonym: stimulation of antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002594
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation via MHC class Ib
subclass of: Restriction
  on property: RO_0002213
  some values from: antigen processing and presentation via MHC class Ib

regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002595
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation via MHC class Ib
subclass of: Restriction
  on property: RO_0002211
  some values from: antigen processing and presentation of peptide antigen via MHC class Ib

negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class Ib
has narrow synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class Ib
has OBO namespace: biological_process
id: GO:0002596
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: negative regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: Restriction
  on property: RO_0002212
  some values from: antigen processing and presentation of peptide antigen via MHC class Ib

positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class Ib
has narrow synonym: activation of antigen processing and presentation of peptide antigen via MHC class Ib
has narrow synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class Ib
has OBO namespace: biological_process
id: GO:0002597
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: positive regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: Restriction
  on property: RO_0002213
  some values from: antigen processing and presentation of peptide antigen via MHC class Ib

regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: regulation of lipid antigen processing and presentation via MHC class Ib
has OBO namespace: biological_process
id: GO:0002598
type: Class
subclass of: regulation of antigen processing and presentation via MHC class Ib
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0048003

negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: down regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: downregulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: negative regulation of lipid antigen processing and presentation via MHC class Ib
has narrow synonym: inhibition of antigen processing and presentation of lipid antigen via MHC class Ib
has OBO namespace: biological_process
id: GO:0002599
type: Class
subclass of: negative regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0048003

positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: positive regulation of lipid antigen processing and presentation via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation of lipid antigen via MHC class Ib
has narrow synonym: activation of antigen processing and presentation of lipid antigen via MHC class Ib
has narrow synonym: stimulation of antigen processing and presentation of lipid antigen via MHC class Ib
has OBO namespace: biological_process
id: GO:0002600
type: Class
subclass of: positive regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0048003

regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: regulation of polysaccharide antigen processing and presentation via MHC class II
has OBO namespace: biological_process
id: GO:0002601
type: Class
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002211
  some values from: antigen processing and presentation of polysaccharide antigen via MHC class II

negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: negative regulation of polysaccharide antigen processing and presentation via MHC class II
has narrow synonym: inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II
has OBO namespace: biological_process
id: GO:0002602
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002212
  some values from: antigen processing and presentation of polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: positive regulation of polysaccharide antigen processing and presentation via MHC class II
has exact synonym: up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has narrow synonym: activation of antigen processing and presentation of polysaccharide antigen via MHC class II
has narrow synonym: stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has OBO namespace: biological_process
id: GO:0002603
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
subclass of: Restriction
  on property: RO_0002213
  some values from: antigen processing and presentation of polysaccharide antigen via MHC class II

regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002604
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: dendritic cell antigen processing and presentation

negative regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has exact synonym: down regulation of dendritic cell antigen processing and presentation
has exact synonym: down-regulation of dendritic cell antigen processing and presentation
has exact synonym: downregulation of dendritic cell antigen processing and presentation
has narrow synonym: inhibition of dendritic cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002605
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: dendritic cell antigen processing and presentation

positive regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has exact synonym: up regulation of dendritic cell antigen processing and presentation
has exact synonym: up-regulation of dendritic cell antigen processing and presentation
has exact synonym: upregulation of dendritic cell antigen processing and presentation
has narrow synonym: activation of dendritic cell antigen processing and presentation
has narrow synonym: stimulation of dendritic cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002606
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: dendritic cell antigen processing and presentation

regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002607
type: Class
subclass of: regulation of dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: myeloid dendritic cell antigen processing and presentation

negative regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has exact synonym: down regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: down-regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: downregulation of myeloid dendritic cell antigen processing and presentation
has narrow synonym: inhibition of myeloid dendritic cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002608
type: Class
subclass of: negative regulation of dendritic cell antigen processing and presentation
subclass of: regulation of myeloid dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: myeloid dendritic cell antigen processing and presentation

positive regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has exact synonym: up regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: up-regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: upregulation of myeloid dendritic cell antigen processing and presentation
has narrow synonym: activation of myeloid dendritic cell antigen processing and presentation
has narrow synonym: stimulation of myeloid dendritic cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002609
type: Class
subclass of: positive regulation of dendritic cell antigen processing and presentation
subclass of: regulation of myeloid dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: myeloid dendritic cell antigen processing and presentation

regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002610
type: Class
subclass of: regulation of dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: plasmacytoid dendritic cell antigen processing and presentation

negative regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has exact synonym: down regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: down-regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: downregulation of plasmacytoid dendritic cell antigen processing and presentation
has narrow synonym: inhibition of plasmacytoid dendritic cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002611
type: Class
subclass of: negative regulation of dendritic cell antigen processing and presentation
subclass of: regulation of plasmacytoid dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: plasmacytoid dendritic cell antigen processing and presentation

positive regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has exact synonym: up regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: up-regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: upregulation of plasmacytoid dendritic cell antigen processing and presentation
has narrow synonym: activation of plasmacytoid dendritic cell antigen processing and presentation
has narrow synonym: stimulation of plasmacytoid dendritic cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002612
type: Class
subclass of: positive regulation of dendritic cell antigen processing and presentation
subclass of: regulation of plasmacytoid dendritic cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: plasmacytoid dendritic cell antigen processing and presentation

regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002613
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: monocyte antigen processing and presentation

negative regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.
has exact synonym: down regulation of monocyte antigen processing and presentation
has exact synonym: down-regulation of monocyte antigen processing and presentation
has exact synonym: downregulation of monocyte antigen processing and presentation
has narrow synonym: inhibition of monocyte antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002614
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of monocyte antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: monocyte antigen processing and presentation

positive regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.
has exact synonym: up regulation of monocyte antigen processing and presentation
has exact synonym: up-regulation of monocyte antigen processing and presentation
has exact synonym: upregulation of monocyte antigen processing and presentation
has narrow synonym: activation of monocyte antigen processing and presentation
has narrow synonym: stimulation of monocyte antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002615
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of monocyte antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: monocyte antigen processing and presentation

regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002616
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: macrophage antigen processing and presentation

negative regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.
has exact synonym: down regulation of macrophage antigen processing and presentation
has exact synonym: down-regulation of macrophage antigen processing and presentation
has exact synonym: downregulation of macrophage antigen processing and presentation
has narrow synonym: inhibition of macrophage antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002617
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of macrophage antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: macrophage antigen processing and presentation

positive regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.
has exact synonym: up regulation of macrophage antigen processing and presentation
has exact synonym: up-regulation of macrophage antigen processing and presentation
has exact synonym: upregulation of macrophage antigen processing and presentation
has narrow synonym: activation of macrophage antigen processing and presentation
has narrow synonym: stimulation of macrophage antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002618
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of macrophage antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: macrophage antigen processing and presentation

regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002619
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: Restriction
  on property: RO_0002211
  some values from: non-professional antigen presenting cell antigen processing and presentation

negative regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has exact synonym: down regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: down-regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: downregulation of non-professional antigen presenting cell antigen processing and presentation
has narrow synonym: inhibition of non-professional antigen presenting cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002620
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of non-professional antigen presenting cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: non-professional antigen presenting cell antigen processing and presentation

positive regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has exact synonym: up regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: up-regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: upregulation of non-professional antigen presenting cell antigen processing and presentation
has narrow synonym: activation of non-professional antigen presenting cell antigen processing and presentation
has narrow synonym: stimulation of non-professional antigen presenting cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002621
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of non-professional antigen presenting cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: non-professional antigen presenting cell antigen processing and presentation

regulation of B cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: regulation of B lymphocyte antigen processing and presentation
has exact synonym: regulation of B-cell antigen processing and presentation
has exact synonym: regulation of B-lymphocyte antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002622
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: regulation of B cell mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: B cell antigen processing and presentation

negative regulation of B cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: down regulation of B cell antigen processing and presentation
has exact synonym: down-regulation of B cell antigen processing and presentation
has exact synonym: downregulation of B cell antigen processing and presentation
has exact synonym: negative regulation of B lymphocyte antigen processing and presentation
has exact synonym: negative regulation of B-cell antigen processing and presentation
has exact synonym: negative regulation of B-lymphocyte antigen processing and presentation
has narrow synonym: inhibition of B cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002623
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of B cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: B cell antigen processing and presentation

positive regulation of B cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: positive regulation of B lymphocyte antigen processing and presentation
has exact synonym: positive regulation of B-cell antigen processing and presentation
has exact synonym: positive regulation of B-lymphocyte antigen processing and presentation
has exact synonym: up regulation of B cell antigen processing and presentation
has exact synonym: up-regulation of B cell antigen processing and presentation
has exact synonym: upregulation of B cell antigen processing and presentation
has narrow synonym: activation of B cell antigen processing and presentation
has narrow synonym: stimulation of B cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002624
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of B cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: B cell antigen processing and presentation

regulation of T cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: regulation of T lymphocyte antigen processing and presentation
has exact synonym: regulation of T-cell antigen processing and presentation
has exact synonym: regulation of T-lymphocyte antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002625
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: regulation of T cell mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell antigen processing and presentation

negative regulation of T cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: down regulation of T cell antigen processing and presentation
has exact synonym: down-regulation of T cell antigen processing and presentation
has exact synonym: downregulation of T cell antigen processing and presentation
has exact synonym: negative regulation of T lymphocyte antigen processing and presentation
has exact synonym: negative regulation of T-cell antigen processing and presentation
has exact synonym: negative regulation of T-lymphocyte antigen processing and presentation
has narrow synonym: inhibition of T cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002626
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of T cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell antigen processing and presentation

positive regulation of T cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: positive regulation of T lymphocyte antigen processing and presentation
has exact synonym: positive regulation of T-cell antigen processing and presentation
has exact synonym: positive regulation of T-lymphocyte antigen processing and presentation
has exact synonym: up regulation of T cell antigen processing and presentation
has exact synonym: up-regulation of T cell antigen processing and presentation
has exact synonym: upregulation of T cell antigen processing and presentation
has narrow synonym: activation of T cell antigen processing and presentation
has narrow synonym: stimulation of T cell antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002627
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of T cell antigen processing and presentation
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell antigen processing and presentation

regulation of proteolysis associated with antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has OBO namespace: biological_process
id: GO:0002628
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: GO_0030162
subclass of: GO_0031329
subclass of: GO_0032268
subclass of: GO_0042176
subclass of: Restriction
  on property: RO_0002211
  some values from: proteolysis associated with antigen processing and presentation

negative regulation of proteolysis associated with antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has exact synonym: down regulation of proteolysis associated with antigen processing and presentation
has exact synonym: down-regulation of proteolysis associated with antigen processing and presentation
has exact synonym: downregulation of proteolysis associated with antigen processing and presentation
has narrow synonym: inhibition of proteolysis associated with antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002629
type: Class
subclass of: regulation of proteolysis associated with antigen processing and presentation
subclass of: GO_0031330
subclass of: GO_0042177
subclass of: GO_0045861
subclass of: Restriction
  on property: RO_0002212
  some values from: proteolysis associated with antigen processing and presentation

positive regulation of proteolysis associated with antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has exact synonym: up regulation of proteolysis associated with antigen processing and presentation
has exact synonym: up-regulation of proteolysis associated with antigen processing and presentation
has exact synonym: upregulation of proteolysis associated with antigen processing and presentation
has narrow synonym: activation of proteolysis associated with antigen processing and presentation
has narrow synonym: stimulation of proteolysis associated with antigen processing and presentation
has OBO namespace: biological_process
id: GO:0002630
type: Class
subclass of: regulation of proteolysis associated with antigen processing and presentation
subclass of: GO_0031331
subclass of: GO_0045732
subclass of: GO_0045862
subclass of: Restriction
  on property: RO_0002213
  some values from: proteolysis associated with antigen processing and presentation

regulation of granuloma formation
IAO_0000115: Any process that modulates the frequency, rate, or extent of granuloma formation.
has OBO namespace: biological_process
id: GO:0002631
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: RO_0002211
  some values from: granuloma formation

negative regulation of granuloma formation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation.
has exact synonym: down regulation of granuloma formation
has exact synonym: down-regulation of granuloma formation
has exact synonym: downregulation of granuloma formation
has narrow synonym: inhibition of granuloma formation
has OBO namespace: biological_process
id: GO:0002632
type: Class
subclass of: regulation of granuloma formation
subclass of: negative regulation of immune effector process
subclass of: Restriction
  on property: RO_0002212
  some values from: granuloma formation

positive regulation of granuloma formation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of granuloma formation.
has exact synonym: up regulation of granuloma formation
has exact synonym: up-regulation of granuloma formation
has exact synonym: upregulation of granuloma formation
has narrow synonym: activation of granuloma formation
has narrow synonym: stimulation of granuloma formation
has OBO namespace: biological_process
id: GO:0002633
type: Class
subclass of: regulation of granuloma formation
subclass of: positive regulation of immune effector process
subclass of: Restriction
  on property: RO_0002213
  some values from: granuloma formation

regulation of germinal center formation
IAO_0000115: Any process that modulates the frequency, rate, or extent of germinal center formation.
has OBO namespace: biological_process
id: GO:0002634
type: Class
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002211
  some values from: germinal center formation

negative regulation of germinal center formation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.
has exact synonym: down regulation of germinal center formation
has exact synonym: down-regulation of germinal center formation
has exact synonym: downregulation of germinal center formation
has narrow synonym: inhibition of germinal center formation
has OBO namespace: biological_process
id: GO:0002635
type: Class
subclass of: regulation of germinal center formation
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002212
  some values from: germinal center formation

positive regulation of germinal center formation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of germinal center formation.
has exact synonym: up regulation of germinal center formation
has exact synonym: up-regulation of germinal center formation
has exact synonym: upregulation of germinal center formation
has narrow synonym: activation of germinal center formation
has narrow synonym: stimulation of germinal center formation
has OBO namespace: biological_process
id: GO:0002636
type: Class
subclass of: regulation of germinal center formation
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002213
  some values from: germinal center formation

regulation of immunoglobulin production
IAO_0000115: Any process that modulates the frequency, rate, or extent of immunoglobulin production.
has OBO namespace: biological_process
id: GO:0002637
type: Class
subclass of: regulation of production of molecular mediator of immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: immunoglobulin production

negative regulation of immunoglobulin production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.
has exact synonym: down regulation of immunoglobulin production
has exact synonym: down-regulation of immunoglobulin production
has exact synonym: downregulation of immunoglobulin production
has narrow synonym: inhibition of immunoglobulin production
has OBO namespace: biological_process
id: GO:0002638
type: Class
subclass of: regulation of immunoglobulin production
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: immunoglobulin production

positive regulation of immunoglobulin production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
has exact synonym: up regulation of immunoglobulin production
has exact synonym: up-regulation of immunoglobulin production
has exact synonym: upregulation of immunoglobulin production
has narrow synonym: activation of immunoglobulin production
has narrow synonym: stimulation of immunoglobulin production
has OBO namespace: biological_process
id: GO:0002639
type: Class
subclass of: regulation of immunoglobulin production
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: immunoglobulin production

regulation of immunoglobulin biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis.
has OBO namespace: biological_process
id: GO:0002640
type: Class
subclass of: regulation of immunoglobulin production
subclass of: GO_0010556
subclass of: Restriction
  on property: RO_0002211
  some values from: immunoglobulin biosynthetic process

negative regulation of immunoglobulin biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis.
has exact synonym: down regulation of immunoglobulin biosynthetic process
has exact synonym: down-regulation of immunoglobulin biosynthetic process
has exact synonym: downregulation of immunoglobulin biosynthetic process
has narrow synonym: inhibition of immunoglobulin biosynthetic process
has OBO namespace: biological_process
id: GO:0002641
type: Class
subclass of: regulation of immunoglobulin biosynthetic process
subclass of: GO_0010558
subclass of: Restriction
  on property: RO_0002212
  some values from: immunoglobulin biosynthetic process

positive regulation of immunoglobulin biosynthetic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis.
has exact synonym: up regulation of immunoglobulin biosynthetic process
has exact synonym: up-regulation of immunoglobulin biosynthetic process
has exact synonym: upregulation of immunoglobulin biosynthetic process
has narrow synonym: activation of immunoglobulin biosynthetic process
has narrow synonym: stimulation of immunoglobulin biosynthetic process
has OBO namespace: biological_process
id: GO:0002642
type: Class
subclass of: regulation of immunoglobulin biosynthetic process
subclass of: GO_0010557
subclass of: Restriction
  on property: RO_0002213
  some values from: immunoglobulin biosynthetic process

regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction.
has OBO namespace: biological_process
id: GO:0002643
type: Class
subclass of: regulation of immune system process
subclass of: GO_2000026
subclass of: Restriction
  on property: RO_0002211
  some values from: tolerance induction

negative regulation of tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.
has exact synonym: down regulation of tolerance induction
has exact synonym: down-regulation of tolerance induction
has exact synonym: downregulation of tolerance induction
has narrow synonym: inhibition of tolerance induction
has OBO namespace: biological_process
id: GO:0002644
type: Class
subclass of: regulation of tolerance induction
subclass of: negative regulation of immune system process
subclass of: Restriction
  on property: RO_0002212
  some values from: tolerance induction

positive regulation of tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction.
has exact synonym: up regulation of tolerance induction
has exact synonym: up-regulation of tolerance induction
has exact synonym: upregulation of tolerance induction
has narrow synonym: activation of tolerance induction
has narrow synonym: stimulation of tolerance induction
has OBO namespace: biological_process
id: GO:0002645
type: Class
subclass of: regulation of tolerance induction
subclass of: positive regulation of immune system process
subclass of: Restriction
  on property: RO_0002213
  some values from: tolerance induction

regulation of central tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of central tolerance induction.
has OBO namespace: biological_process
id: GO:0002646
type: Class
subclass of: regulation of tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: central tolerance induction

negative regulation of central tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction.
has exact synonym: down regulation of central tolerance induction
has exact synonym: down-regulation of central tolerance induction
has exact synonym: downregulation of central tolerance induction
has narrow synonym: inhibition of central tolerance induction
has OBO namespace: biological_process
id: GO:0002647
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of central tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: central tolerance induction

positive regulation of central tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central tolerance induction.
has exact synonym: up regulation of central tolerance induction
has exact synonym: up-regulation of central tolerance induction
has exact synonym: upregulation of central tolerance induction
has narrow synonym: activation of central tolerance induction
has narrow synonym: stimulation of central tolerance induction
has OBO namespace: biological_process
id: GO:0002648
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of central tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: central tolerance induction

regulation of tolerance induction to self antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen.
has OBO namespace: biological_process
id: GO:0002649
type: Class
subclass of: regulation of tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: tolerance induction to self antigen

negative regulation of tolerance induction to self antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen.
has exact synonym: down regulation of tolerance induction to self antigen
has exact synonym: down-regulation of tolerance induction to self antigen
has exact synonym: downregulation of tolerance induction to self antigen
has narrow synonym: inhibition of tolerance induction to self antigen
has OBO namespace: biological_process
id: GO:0002650
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of tolerance induction to self antigen
subclass of: Restriction
  on property: RO_0002212
  some values from: tolerance induction to self antigen

positive regulation of tolerance induction to self antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen.
has exact synonym: up regulation of tolerance induction to self antigen
has exact synonym: up-regulation of tolerance induction to self antigen
has exact synonym: upregulation of tolerance induction to self antigen
has narrow synonym: activation of tolerance induction to self antigen
has narrow synonym: stimulation of tolerance induction to self antigen
has OBO namespace: biological_process
id: GO:0002651
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of tolerance induction to self antigen
subclass of: Restriction
  on property: RO_0002213
  some values from: tolerance induction to self antigen

regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: regulation of immune response-dependent tolerance induction
has OBO namespace: biological_process
id: GO:0002652
type: Class
subclass of: regulation of tolerance induction
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002211
  some values from: tolerance induction dependent upon immune response

negative regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: down regulation of tolerance induction dependent upon immune response
has exact synonym: down-regulation of tolerance induction dependent upon immune response
has exact synonym: downregulation of tolerance induction dependent upon immune response
has exact synonym: negative regulation of immune response-dependent tolerance induction
has narrow synonym: inhibition of tolerance induction dependent upon immune response
has OBO namespace: biological_process
id: GO:0002653
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002212
  some values from: tolerance induction dependent upon immune response

positive regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: positive regulation of immune response-dependent tolerance induction
has exact synonym: up regulation of tolerance induction dependent upon immune response
has exact synonym: up-regulation of tolerance induction dependent upon immune response
has exact synonym: upregulation of tolerance induction dependent upon immune response
has narrow synonym: activation of tolerance induction dependent upon immune response
has narrow synonym: stimulation of tolerance induction dependent upon immune response
has OBO namespace: biological_process
id: GO:0002654
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002213
  some values from: tolerance induction dependent upon immune response

regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen.
has OBO namespace: biological_process
id: GO:0002655
type: Class
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: tolerance induction to nonself antigen

negative regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen.
has exact synonym: down regulation of tolerance induction to nonself antigen
has exact synonym: down-regulation of tolerance induction to nonself antigen
has exact synonym: downregulation of tolerance induction to nonself antigen
has narrow synonym: inhibition of tolerance induction to nonself antigen
has OBO namespace: biological_process
id: GO:0002656
type: Class
subclass of: negative regulation of tolerance induction dependent upon immune response
subclass of: regulation of tolerance induction to nonself antigen
subclass of: Restriction
  on property: RO_0002212
  some values from: tolerance induction to nonself antigen

positive regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.
has exact synonym: up regulation of tolerance induction to nonself antigen
has exact synonym: up-regulation of tolerance induction to nonself antigen
has exact synonym: upregulation of tolerance induction to nonself antigen
has narrow synonym: activation of tolerance induction to nonself antigen
has narrow synonym: stimulation of tolerance induction to nonself antigen
has OBO namespace: biological_process
id: GO:0002657
type: Class
subclass of: positive regulation of tolerance induction dependent upon immune response
subclass of: regulation of tolerance induction to nonself antigen
subclass of: Restriction
  on property: RO_0002213
  some values from: tolerance induction to nonself antigen

regulation of peripheral tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.
has OBO namespace: biological_process
id: GO:0002658
type: Class
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: peripheral tolerance induction

negative regulation of peripheral tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.
has exact synonym: down regulation of peripheral tolerance induction
has exact synonym: down-regulation of peripheral tolerance induction
has exact synonym: downregulation of peripheral tolerance induction
has narrow synonym: inhibition of peripheral tolerance induction
has OBO namespace: biological_process
id: GO:0002659
type: Class
subclass of: negative regulation of tolerance induction dependent upon immune response
subclass of: regulation of peripheral tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: peripheral tolerance induction

positive regulation of peripheral tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.
has exact synonym: up regulation of peripheral tolerance induction
has exact synonym: up-regulation of peripheral tolerance induction
has exact synonym: upregulation of peripheral tolerance induction
has narrow synonym: activation of peripheral tolerance induction
has narrow synonym: stimulation of peripheral tolerance induction
has OBO namespace: biological_process
id: GO:0002660
type: Class
subclass of: positive regulation of tolerance induction dependent upon immune response
subclass of: regulation of peripheral tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: peripheral tolerance induction

regulation of B cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: regulation of B lymphocyte tolerance induction
has exact synonym: regulation of B-cell tolerance induction
has exact synonym: regulation of B-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002661
type: Class
subclass of: regulation of tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: B cell tolerance induction

negative regulation of B cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: down regulation of B cell tolerance induction
has exact synonym: down-regulation of B cell tolerance induction
has exact synonym: downregulation of B cell tolerance induction
has exact synonym: negative regulation of B lymphocyte tolerance induction
has exact synonym: negative regulation of B-cell tolerance induction
has exact synonym: negative regulation of B-lymphocyte tolerance induction
has narrow synonym: inhibition of B cell tolerance induction
has OBO namespace: biological_process
id: GO:0002662
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of B cell tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: B cell tolerance induction

positive regulation of B cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: positive regulation of B lymphocyte tolerance induction
has exact synonym: positive regulation of B-cell tolerance induction
has exact synonym: positive regulation of B-lymphocyte tolerance induction
has exact synonym: up regulation of B cell tolerance induction
has exact synonym: up-regulation of B cell tolerance induction
has exact synonym: upregulation of B cell tolerance induction
has narrow synonym: activation of B cell tolerance induction
has narrow synonym: stimulation of B cell tolerance induction
has OBO namespace: biological_process
id: GO:0002663
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of B cell tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: B cell tolerance induction

regulation of T cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: regulation of T lymphocyte tolerance induction
has exact synonym: regulation of T-cell tolerance induction
has exact synonym: regulation of T-lymphocyte tolerance induction
has OBO namespace: biological_process
id: GO:0002664
type: Class
subclass of: regulation of tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell tolerance induction

negative regulation of T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: down regulation of T cell tolerance induction
has exact synonym: down-regulation of T cell tolerance induction
has exact synonym: downregulation of T cell tolerance induction
has exact synonym: negative regulation of T lymphocyte tolerance induction
has exact synonym: negative regulation of T-cell tolerance induction
has exact synonym: negative regulation of T-lymphocyte tolerance induction
has narrow synonym: inhibition of T cell tolerance induction
has OBO namespace: biological_process
id: GO:0002665
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of T cell tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell tolerance induction

positive regulation of T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: positive regulation of T lymphocyte tolerance induction
has exact synonym: positive regulation of T-cell tolerance induction
has exact synonym: positive regulation of T-lymphocyte tolerance induction
has exact synonym: up regulation of T cell tolerance induction
has exact synonym: up-regulation of T cell tolerance induction
has exact synonym: upregulation of T cell tolerance induction
has narrow synonym: activation of T cell tolerance induction
has narrow synonym: stimulation of T cell tolerance induction
has OBO namespace: biological_process
id: GO:0002666
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of T cell tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell tolerance induction

regulation of T cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell anergy.
has exact synonym: regulation of T lymphocyte anergy
has exact synonym: regulation of T-cell anergy
has exact synonym: regulation of T-lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002667
type: Class
subclass of: regulation of T cell tolerance induction
subclass of: regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell anergy

negative regulation of T cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy.
has exact synonym: down regulation of T cell anergy
has exact synonym: down-regulation of T cell anergy
has exact synonym: downregulation of T cell anergy
has exact synonym: negative regulation of T lymphocyte anergy
has exact synonym: negative regulation of T-cell anergy
has exact synonym: negative regulation of T-lymphocyte anergy
has narrow synonym: inhibition of T cell anergy
has OBO namespace: biological_process
id: GO:0002668
type: Class
subclass of: negative regulation of T cell tolerance induction
subclass of: regulation of T cell anergy
subclass of: negative regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell anergy

positive regulation of T cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell anergy.
has exact synonym: positive regulation of T lymphocyte anergy
has exact synonym: positive regulation of T-cell anergy
has exact synonym: positive regulation of T-lymphocyte anergy
has exact synonym: up regulation of T cell anergy
has exact synonym: up-regulation of T cell anergy
has exact synonym: upregulation of T cell anergy
has narrow synonym: activation of T cell anergy
has narrow synonym: stimulation of T cell anergy
has OBO namespace: biological_process
id: GO:0002669
type: Class
subclass of: positive regulation of T cell tolerance induction
subclass of: regulation of T cell anergy
subclass of: positive regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell anergy

regulation of B cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell anergy.
has exact synonym: regulation of B lymphocyte anergy
has exact synonym: regulation of B-cell anergy
has exact synonym: regulation of B-lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002670
type: Class
subclass of: regulation of B cell tolerance induction
subclass of: regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002211
  some values from: B cell anergy

negative regulation of B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy.
has exact synonym: down regulation of B cell anergy
has exact synonym: down-regulation of B cell anergy
has exact synonym: downregulation of B cell anergy
has exact synonym: negative regulation of B lymphocyte anergy
has exact synonym: negative regulation of B-cell anergy
has exact synonym: negative regulation of B-lymphocyte anergy
has narrow synonym: inhibition of B cell anergy
has OBO namespace: biological_process
id: GO:0002671
type: Class
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of B cell anergy
subclass of: negative regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002212
  some values from: B cell anergy

positive regulation of B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell anergy.
has exact synonym: positive regulation of B lymphocyte anergy
has exact synonym: positive regulation of B-cell anergy
has exact synonym: positive regulation of B-lymphocyte anergy
has exact synonym: up regulation of B cell anergy
has exact synonym: up-regulation of B cell anergy
has exact synonym: upregulation of B cell anergy
has narrow synonym: activation of B cell anergy
has narrow synonym: stimulation of B cell anergy
has OBO namespace: biological_process
id: GO:0002672
type: Class
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of B cell anergy
subclass of: positive regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002213
  some values from: B cell anergy

regulation of acute inflammatory response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
has OBO namespace: biological_process
id: GO:0002673
type: Class
subclass of: GO_0050727
subclass of: Restriction
  on property: RO_0002211
  some values from: acute inflammatory response

negative regulation of acute inflammatory response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
has exact synonym: down regulation of acute inflammatory response
has exact synonym: down-regulation of acute inflammatory response
has exact synonym: downregulation of acute inflammatory response
has narrow synonym: inhibition of acute inflammatory response
has OBO namespace: biological_process
id: GO:0002674
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0050728
subclass of: Restriction
  on property: RO_0002212
  some values from: acute inflammatory response

positive regulation of acute inflammatory response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
has exact synonym: up regulation of acute inflammatory response
has exact synonym: up-regulation of acute inflammatory response
has exact synonym: upregulation of acute inflammatory response
has narrow synonym: activation of acute inflammatory response
has narrow synonym: stimulation of acute inflammatory response
has OBO namespace: biological_process
id: GO:0002675
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0050729
subclass of: Restriction
  on property: RO_0002213
  some values from: acute inflammatory response

regulation of chronic inflammatory response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.
has OBO namespace: biological_process
id: GO:0002676
type: Class
subclass of: GO_0050727
subclass of: Restriction
  on property: RO_0002211
  some values from: chronic inflammatory response

negative regulation of chronic inflammatory response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
has exact synonym: down regulation of chronic inflammatory response
has exact synonym: down-regulation of chronic inflammatory response
has exact synonym: downregulation of chronic inflammatory response
has narrow synonym: inhibition of chronic inflammatory response
has OBO namespace: biological_process
id: GO:0002677
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: GO_0050728
subclass of: Restriction
  on property: RO_0002212
  some values from: chronic inflammatory response

positive regulation of chronic inflammatory response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.
has exact synonym: up regulation of chronic inflammatory response
has exact synonym: up-regulation of chronic inflammatory response
has exact synonym: upregulation of chronic inflammatory response
has narrow synonym: activation of chronic inflammatory response
has narrow synonym: stimulation of chronic inflammatory response
has OBO namespace: biological_process
id: GO:0002678
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: GO_0050729
subclass of: Restriction
  on property: RO_0002213
  some values from: chronic inflammatory response

respiratory burst involved in defense response
IAO_0000115: A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
has OBO namespace: biological_process
id: GO:0002679
type: Class
subclass of: immune effector process
subclass of: GO_0045730
subclass of: Restriction
  on property: part_of
  some values from: GO_0006952

pro-T cell lineage commitment
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell.
has exact synonym: pro-T cell fate commitment
has exact synonym: pro-T lymphocyte fate commitment
has exact synonym: pro-T lymphocyte lineage commitment
has OBO namespace: biological_process
id: GO:0002680
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: pro-T cell differentiation

somatic recombination of T cell receptor gene segments
IAO_0000115: The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments.
has exact synonym: somatic recombination of TCR gene segments
has OBO namespace: biological_process
id: GO:0002681
type: Class
subclass of: somatic diversification of immune receptors via germline recombination within a single locus
subclass of: somatic diversification of T cell receptor genes

regulation of immune system process
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune system process.
has OBO namespace: biological_process
id: GO:0002682
type: Class
subclass of: GO_0050789
subclass of: Restriction
  on property: RO_0002211
  some values from: immune system process

negative regulation of immune system process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
has exact synonym: down regulation of immune system process
has exact synonym: down-regulation of immune system process
has exact synonym: downregulation of immune system process
has narrow synonym: inhibition of immune system process
has OBO namespace: biological_process
id: GO:0002683
type: Class
subclass of: regulation of immune system process
subclass of: GO_0048519
subclass of: Restriction
  on property: RO_0002212
  some values from: immune system process

positive regulation of immune system process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune system process.
has exact synonym: up regulation of immune system process
has exact synonym: up-regulation of immune system process
has exact synonym: upregulation of immune system process
has narrow synonym: activation of immune system process
has narrow synonym: stimulation of immune system process
has OBO namespace: biological_process
id: GO:0002684
type: Class
subclass of: regulation of immune system process
subclass of: GO_0048518
subclass of: Restriction
  on property: RO_0002213
  some values from: immune system process

regulation of leukocyte migration
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte migration.
has exact synonym: regulation of immune cell migration
has exact synonym: regulation of leucocyte migration
has OBO namespace: biological_process
id: GO:0002685
type: Class
subclass of: regulation of immune system process
subclass of: GO_0030334
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0050900

negative regulation of leukocyte migration
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
has exact synonym: down regulation of leukocyte migration
has exact synonym: down-regulation of leukocyte migration
has exact synonym: downregulation of leukocyte migration
has exact synonym: negative regulation of immune cell migration
has exact synonym: negative regulation of leucocyte migration
has narrow synonym: inhibition of leukocyte migration
has OBO namespace: biological_process
id: GO:0002686
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte migration
subclass of: GO_0030336
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0050900

positive regulation of leukocyte migration
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
has exact synonym: positive regulation of immune cell migration
has exact synonym: positive regulation of leucocyte migration
has exact synonym: up regulation of leukocyte migration
has exact synonym: up-regulation of leukocyte migration
has exact synonym: upregulation of leukocyte migration
has narrow synonym: activation of leukocyte migration
has narrow synonym: stimulation of leukocyte migration
has OBO namespace: biological_process
id: GO:0002687
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte migration
subclass of: GO_0030335
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0050900

regulation of leukocyte chemotaxis
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: regulation of immune cell chemotaxis
has exact synonym: regulation of leucocyte chemotaxis
has OBO namespace: biological_process
id: GO:0002688
type: Class
subclass of: regulation of leukocyte migration
subclass of: GO_0050920
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0030595

negative regulation of leukocyte chemotaxis
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: down regulation of leukocyte chemotaxis
has exact synonym: down-regulation of leukocyte chemotaxis
has exact synonym: downregulation of leukocyte chemotaxis
has exact synonym: negative regulation of immune cell chemotaxis
has exact synonym: negative regulation of leucocyte chemotaxis
has narrow synonym: inhibition of leukocyte chemotaxis
has OBO namespace: biological_process
id: GO:0002689
type: Class
subclass of: negative regulation of leukocyte migration
subclass of: regulation of leukocyte chemotaxis
subclass of: GO_0050922
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0030595

positive regulation of leukocyte chemotaxis
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: positive regulation of immune cell chemotaxis
has exact synonym: positive regulation of leucocyte chemotaxis
has exact synonym: up regulation of leukocyte chemotaxis
has exact synonym: up-regulation of leukocyte chemotaxis
has exact synonym: upregulation of leukocyte chemotaxis
has narrow synonym: activation of leukocyte chemotaxis
has narrow synonym: stimulation of leukocyte chemotaxis
has OBO namespace: biological_process
id: GO:0002690
type: Class
subclass of: positive regulation of leukocyte migration
subclass of: regulation of leukocyte chemotaxis
subclass of: GO_0050921
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0030595

regulation of cellular extravasation
IAO_0000115: Any process that modulates the frequency, rate, or extent of cellular extravasation.
has OBO namespace: biological_process
id: GO:0002691
type: Class
subclass of: regulation of leukocyte migration
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0045123

negative regulation of cellular extravasation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.
has exact synonym: down regulation of cellular extravasation
has exact synonym: down-regulation of cellular extravasation
has exact synonym: downregulation of cellular extravasation
has narrow synonym: inhibition of cellular extravasation
has OBO namespace: biological_process
id: GO:0002692
type: Class
subclass of: negative regulation of leukocyte migration
subclass of: regulation of cellular extravasation
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0045123

positive regulation of cellular extravasation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cellular extravasation.
has exact synonym: up regulation of cellular extravasation
has exact synonym: up-regulation of cellular extravasation
has exact synonym: upregulation of cellular extravasation
has narrow synonym: activation of cellular extravasation
has narrow synonym: stimulation of cellular extravasation
has OBO namespace: biological_process
id: GO:0002693
type: Class
subclass of: positive regulation of leukocyte migration
subclass of: regulation of cellular extravasation
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0045123

regulation of leukocyte activation
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte activation.
has exact synonym: regulation of immune cell activation
has exact synonym: regulation of leucocyte activation
has OBO namespace: biological_process
id: GO:0002694
type: Class
subclass of: regulation of immune system process
subclass of: GO_0050865
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0045321

negative regulation of leukocyte activation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
has exact synonym: down regulation of leukocyte activation
has exact synonym: down-regulation of leukocyte activation
has exact synonym: downregulation of leukocyte activation
has exact synonym: negative regulation of immune cell activation
has exact synonym: negative regulation of leucocyte activation
has narrow synonym: inhibition of leukocyte activation
has OBO namespace: biological_process
id: GO:0002695
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050866
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0045321

positive regulation of leukocyte activation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
has exact synonym: positive regulation of immune cell activation
has exact synonym: positive regulation of leucocyte activation
has exact synonym: up regulation of leukocyte activation
has exact synonym: up-regulation of leukocyte activation
has exact synonym: upregulation of leukocyte activation
has narrow synonym: activation of leukocyte activation
has narrow synonym: stimulation of leukocyte activation
has OBO namespace: biological_process
id: GO:0002696
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050867
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0045321

regulation of immune effector process
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune effector process.
has OBO namespace: biological_process
id: GO:0002697
type: Class
subclass of: regulation of immune system process
subclass of: Restriction
  on property: RO_0002211
  some values from: immune effector process

negative regulation of immune effector process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
has exact synonym: down regulation of immune effector process
has exact synonym: down-regulation of immune effector process
has exact synonym: downregulation of immune effector process
has narrow synonym: inhibition of immune effector process
has OBO namespace: biological_process
id: GO:0002698
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: RO_0002212
  some values from: immune effector process

positive regulation of immune effector process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune effector process.
has exact synonym: up regulation of immune effector process
has exact synonym: up-regulation of immune effector process
has exact synonym: upregulation of immune effector process
has narrow synonym: activation of immune effector process
has narrow synonym: stimulation of immune effector process
has OBO namespace: biological_process
id: GO:0002699
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: RO_0002213
  some values from: immune effector process

regulation of production of molecular mediator of immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.
has OBO namespace: biological_process
id: GO:0002700
type: Class
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: RO_0002211
  some values from: production of molecular mediator of immune response

negative regulation of production of molecular mediator of immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.
has exact synonym: down regulation of production of molecular mediator of immune response
has exact synonym: down-regulation of production of molecular mediator of immune response
has exact synonym: downregulation of production of molecular mediator of immune response
has narrow synonym: inhibition of production of molecular mediator of immune response
has OBO namespace: biological_process
id: GO:0002701
type: Class
subclass of: negative regulation of immune effector process
subclass of: regulation of production of molecular mediator of immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: production of molecular mediator of immune response

positive regulation of production of molecular mediator of immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.
has exact synonym: up regulation of production of molecular mediator of immune response
has exact synonym: up-regulation of production of molecular mediator of immune response
has exact synonym: upregulation of production of molecular mediator of immune response
has narrow synonym: activation of production of molecular mediator of immune response
has narrow synonym: stimulation of production of molecular mediator of immune response
has OBO namespace: biological_process
id: GO:0002702
type: Class
subclass of: positive regulation of immune effector process
subclass of: regulation of production of molecular mediator of immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: production of molecular mediator of immune response

regulation of leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: regulation of immune cell mediated immunity
has exact synonym: regulation of leucocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002703
type: Class
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: RO_0002211
  some values from: leukocyte mediated immunity

negative regulation of leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: down regulation of leukocyte mediated immunity
has exact synonym: down-regulation of leukocyte mediated immunity
has exact synonym: downregulation of leukocyte mediated immunity
has exact synonym: negative regulation of immune cell mediated immunity
has exact synonym: negative regulation of leucocyte mediated immunity
has narrow synonym: inhibition of leukocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002704
type: Class
subclass of: negative regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: RO_0002212
  some values from: leukocyte mediated immunity

positive regulation of leukocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: positive regulation of immune cell mediated immunity
has exact synonym: positive regulation of leucocyte mediated immunity
has exact synonym: up regulation of leukocyte mediated immunity
has exact synonym: up-regulation of leukocyte mediated immunity
has exact synonym: upregulation of leukocyte mediated immunity
has narrow synonym: activation of leukocyte mediated immunity
has narrow synonym: stimulation of leukocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002705
type: Class
subclass of: positive regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: RO_0002213
  some values from: leukocyte mediated immunity

regulation of lymphocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
has OBO namespace: biological_process
id: GO:0002706
type: Class
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: lymphocyte mediated immunity

negative regulation of lymphocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
has exact synonym: down regulation of lymphocyte mediated immunity
has exact synonym: down-regulation of lymphocyte mediated immunity
has exact synonym: downregulation of lymphocyte mediated immunity
has narrow synonym: inhibition of lymphocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002707
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity
subclass of: Restriction
  on property: RO_0002212
  some values from: lymphocyte mediated immunity

positive regulation of lymphocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
has exact synonym: up regulation of lymphocyte mediated immunity
has exact synonym: up-regulation of lymphocyte mediated immunity
has exact synonym: upregulation of lymphocyte mediated immunity
has narrow synonym: activation of lymphocyte mediated immunity
has narrow synonym: stimulation of lymphocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002708
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity
subclass of: Restriction
  on property: RO_0002213
  some values from: lymphocyte mediated immunity

regulation of T cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: regulation of T lymphocyte mediated immunity
has exact synonym: regulation of T-cell mediated immunity
has exact synonym: regulation of T-lymphocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002709
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell mediated immunity

negative regulation of T cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: down regulation of T cell mediated immunity
has exact synonym: down-regulation of T cell mediated immunity
has exact synonym: downregulation of T cell mediated immunity
has exact synonym: negative regulation of T lymphocyte mediated immunity
has exact synonym: negative regulation of T-cell mediated immunity
has exact synonym: negative regulation of T-lymphocyte mediated immunity
has narrow synonym: inhibition of T cell mediated immunity
has OBO namespace: biological_process
id: GO:0002710
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of T cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell mediated immunity

positive regulation of T cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: positive regulation of T lymphocyte mediated immunity
has exact synonym: positive regulation of T-cell mediated immunity
has exact synonym: positive regulation of T-lymphocyte mediated immunity
has exact synonym: up regulation of T cell mediated immunity
has exact synonym: up-regulation of T cell mediated immunity
has exact synonym: upregulation of T cell mediated immunity
has narrow synonym: activation of T cell mediated immunity
has narrow synonym: stimulation of T cell mediated immunity
has OBO namespace: biological_process
id: GO:0002711
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of T cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell mediated immunity

regulation of B cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: regulation of B lymphocyte mediated immunity
has exact synonym: regulation of B-cell mediated immunity
has exact synonym: regulation of B-lymphocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002712
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0019724

negative regulation of B cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: down regulation of B cell mediated immunity
has exact synonym: down-regulation of B cell mediated immunity
has exact synonym: downregulation of B cell mediated immunity
has exact synonym: negative regulation of B lymphocyte mediated immunity
has exact synonym: negative regulation of B-cell mediated immunity
has exact synonym: negative regulation of B-lymphocyte mediated immunity
has narrow synonym: inhibition of B cell mediated immunity
has OBO namespace: biological_process
id: GO:0002713
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0019724

positive regulation of B cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: positive regulation of B lymphocyte mediated immunity
has exact synonym: positive regulation of B-cell mediated immunity
has exact synonym: positive regulation of B-lymphocyte mediated immunity
has exact synonym: up regulation of B cell mediated immunity
has exact synonym: up-regulation of B cell mediated immunity
has exact synonym: upregulation of B cell mediated immunity
has narrow synonym: activation of B cell mediated immunity
has narrow synonym: stimulation of B cell mediated immunity
has OBO namespace: biological_process
id: GO:0002714
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0019724

regulation of natural killer cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.
has alternative id: GO:0045845
has exact synonym: regulation of NK cell mediated immunity
has OBO namespace: biological_process
has related synonym: regulation of natural killer cell activity
id: GO:0002715
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: GO_0045088
subclass of: Restriction
  on property: RO_0002211
  some values from: natural killer cell mediated immunity

negative regulation of natural killer cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.
has alternative id: GO:0030102
has exact synonym: down regulation of natural killer cell mediated immunity
has exact synonym: down-regulation of natural killer cell mediated immunity
has exact synonym: downregulation of natural killer cell mediated immunity
has exact synonym: negative regulation of NK cell mediated immunity
has narrow synonym: inhibition of natural killer cell mediated immunity
has OBO namespace: biological_process
has related synonym: negative regulation of NK cell activity
has related synonym: negative regulation of natural killer cell activity
id: GO:0002716
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of natural killer cell mediated immunity
subclass of: GO_0045824
subclass of: Restriction
  on property: RO_0002212
  some values from: natural killer cell mediated immunity

positive regulation of natural killer cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.
has alternative id: GO:0045846
has exact synonym: positive regulation of NK cell mediated immunity
has exact synonym: up regulation of natural killer cell mediated immunity
has exact synonym: up-regulation of natural killer cell mediated immunity
has exact synonym: upregulation of natural killer cell mediated immunity
has narrow synonym: activation of natural killer cell mediated immunity
has narrow synonym: stimulation of natural killer cell mediated immunity
has OBO namespace: biological_process
has related synonym: positive regulation of NK cell activity
has related synonym: positive regulation of natural killer cell activity
id: GO:0002717
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of natural killer cell mediated immunity
subclass of: GO_0045089
subclass of: Restriction
  on property: RO_0002213
  some values from: natural killer cell mediated immunity

regulation of cytokine production involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.
has OBO namespace: biological_process
has related synonym: regulation of cytokine production during immune response
id: GO:0002718
type: Class
subclass of: regulation of cytokine production
subclass of: regulation of production of molecular mediator of immune response
subclass of: GO_0050776
subclass of: Restriction
  on property: RO_0002211
  some values from: cytokine production involved in immune response

negative regulation of cytokine production involved in immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.
has exact synonym: down-regulation of cytokine production during immune response
has OBO namespace: biological_process
has related synonym: down regulation of cytokine production during immune response
has related synonym: downregulation of cytokine production during immune response
has related synonym: inhibition of cytokine production during immune response
has related synonym: negative regulation of cytokine production during immune response
id: GO:0002719
type: Class
subclass of: negative regulation of cytokine production
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: regulation of cytokine production involved in immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: cytokine production involved in immune response

positive regulation of cytokine production involved in immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
has narrow synonym: activation of cytokine production during immune response
has narrow synonym: stimulation of cytokine production during immune response
has OBO namespace: biological_process
has related synonym: positive regulation of cytokine production during immune response
has related synonym: up regulation of cytokine production during immune response
has related synonym: up-regulation of cytokine production during immune response
has related synonym: upregulation of cytokine production during immune response
id: GO:0002720
type: Class
subclass of: positive regulation of cytokine production
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: regulation of cytokine production involved in immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: cytokine production involved in immune response

regulation of B cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell cytokine production.
has exact synonym: regulation of B lymphocyte cytokine production
has exact synonym: regulation of B-cell cytokine production
has exact synonym: regulation of B-lymphocyte cytokine production
has OBO namespace: biological_process
id: GO:0002721
type: Class
subclass of: regulation of B cell mediated immunity
subclass of: regulation of cytokine production involved in immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: B cell cytokine production

negative regulation of B cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production.
has exact synonym: down regulation of B cell cytokine production
has exact synonym: down-regulation of B cell cytokine production
has exact synonym: downregulation of B cell cytokine production
has exact synonym: negative regulation of B lymphocyte cytokine production
has exact synonym: negative regulation of B-cell cytokine production
has exact synonym: negative regulation of B-lymphocyte cytokine production
has narrow synonym: inhibition of B cell cytokine production
has OBO namespace: biological_process
id: GO:0002722
type: Class
subclass of: negative regulation of B cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of B cell cytokine production
subclass of: Restriction
  on property: RO_0002212
  some values from: B cell cytokine production

positive regulation of B cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell cytokine production.
has exact synonym: positive regulation of B lymphocyte cytokine production
has exact synonym: positive regulation of B-cell cytokine production
has exact synonym: positive regulation of B-lymphocyte cytokine production
has exact synonym: up regulation of B cell cytokine production
has exact synonym: up-regulation of B cell cytokine production
has exact synonym: upregulation of B cell cytokine production
has narrow synonym: activation of B cell cytokine production
has narrow synonym: stimulation of B cell cytokine production
has OBO namespace: biological_process
id: GO:0002723
type: Class
subclass of: positive regulation of B cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of B cell cytokine production
subclass of: Restriction
  on property: RO_0002213
  some values from: B cell cytokine production

regulation of T cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell cytokine production.
has exact synonym: regulation of T lymphocyte cytokine production
has exact synonym: regulation of T-cell cytokine production
has exact synonym: regulation of T-lymphocyte cytokine production
has OBO namespace: biological_process
id: GO:0002724
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of cytokine production involved in immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell cytokine production

negative regulation of T cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
has exact synonym: down regulation of T cell cytokine production
has exact synonym: down-regulation of T cell cytokine production
has exact synonym: downregulation of T cell cytokine production
has exact synonym: negative regulation of T lymphocyte cytokine production
has exact synonym: negative regulation of T-cell cytokine production
has exact synonym: negative regulation of T-lymphocyte cytokine production
has narrow synonym: inhibition of T cell cytokine production
has OBO namespace: biological_process
id: GO:0002725
type: Class
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of T cell cytokine production
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell cytokine production

positive regulation of T cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
has exact synonym: positive regulation of T lymphocyte cytokine production
has exact synonym: positive regulation of T-cell cytokine production
has exact synonym: positive regulation of T-lymphocyte cytokine production
has exact synonym: up regulation of T cell cytokine production
has exact synonym: up-regulation of T cell cytokine production
has exact synonym: upregulation of T cell cytokine production
has narrow synonym: activation of T cell cytokine production
has narrow synonym: stimulation of T cell cytokine production
has OBO namespace: biological_process
id: GO:0002726
type: Class
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of T cell cytokine production
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell cytokine production

regulation of natural killer cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: regulation of NK cell cytokine production
has OBO namespace: biological_process
id: GO:0002727
type: Class
subclass of: regulation of natural killer cell mediated immunity
subclass of: regulation of cytokine production involved in immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: natural killer cell cytokine production

negative regulation of natural killer cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: down regulation of natural killer cell cytokine production
has exact synonym: down-regulation of natural killer cell cytokine production
has exact synonym: downregulation of natural killer cell cytokine production
has exact synonym: negative regulation of NK cell cytokine production
has narrow synonym: inhibition of natural killer cell cytokine production
has OBO namespace: biological_process
id: GO:0002728
type: Class
subclass of: negative regulation of natural killer cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of natural killer cell cytokine production
subclass of: Restriction
  on property: RO_0002212
  some values from: natural killer cell cytokine production

positive regulation of natural killer cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: positive regulation of NK cell cytokine production
has exact synonym: up regulation of natural killer cell cytokine production
has exact synonym: up-regulation of natural killer cell cytokine production
has exact synonym: upregulation of natural killer cell cytokine production
has narrow synonym: activation of natural killer cell cytokine production
has narrow synonym: stimulation of natural killer cell cytokine production
has OBO namespace: biological_process
id: GO:0002729
type: Class
subclass of: positive regulation of natural killer cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of natural killer cell cytokine production
subclass of: Restriction
  on property: RO_0002213
  some values from: natural killer cell cytokine production

regulation of dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.
has OBO namespace: biological_process
id: GO:0002730
type: Class
subclass of: regulation of cytokine production involved in immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: dendritic cell cytokine production

negative regulation of dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.
has exact synonym: down regulation of dendritic cell cytokine production
has exact synonym: down-regulation of dendritic cell cytokine production
has exact synonym: downregulation of dendritic cell cytokine production
has narrow synonym: inhibition of dendritic cell cytokine production
has OBO namespace: biological_process
id: GO:0002731
type: Class
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002212
  some values from: dendritic cell cytokine production

positive regulation of dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.
has exact synonym: up regulation of dendritic cell cytokine production
has exact synonym: up-regulation of dendritic cell cytokine production
has exact synonym: upregulation of dendritic cell cytokine production
has narrow synonym: activation of dendritic cell cytokine production
has narrow synonym: stimulation of dendritic cell cytokine production
has OBO namespace: biological_process
id: GO:0002732
type: Class
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002213
  some values from: dendritic cell cytokine production

regulation of myeloid dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has OBO namespace: biological_process
id: GO:0002733
type: Class
subclass of: regulation of dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002211
  some values from: myeloid dendritic cell cytokine production

negative regulation of myeloid dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has exact synonym: down regulation of myeloid dendritic cell cytokine production
has exact synonym: down-regulation of myeloid dendritic cell cytokine production
has exact synonym: downregulation of myeloid dendritic cell cytokine production
has narrow synonym: inhibition of myeloid dendritic cell cytokine production
has OBO namespace: biological_process
id: GO:0002734
type: Class
subclass of: negative regulation of dendritic cell cytokine production
subclass of: regulation of myeloid dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002212
  some values from: myeloid dendritic cell cytokine production

positive regulation of myeloid dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has exact synonym: up regulation of myeloid dendritic cell cytokine production
has exact synonym: up-regulation of myeloid dendritic cell cytokine production
has exact synonym: upregulation of myeloid dendritic cell cytokine production
has narrow synonym: activation of myeloid dendritic cell cytokine production
has narrow synonym: stimulation of myeloid dendritic cell cytokine production
has OBO namespace: biological_process
id: GO:0002735
type: Class
subclass of: positive regulation of dendritic cell cytokine production
subclass of: regulation of myeloid dendritic cell cytokine production
subclass of: GO_0061081
subclass of: Restriction
  on property: RO_0002213
  some values from: myeloid dendritic cell cytokine production

regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has OBO namespace: biological_process
id: GO:0002736
type: Class
subclass of: regulation of dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002211
  some values from: plasmacytoid dendritic cell cytokine production

negative regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has exact synonym: down regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: down-regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: downregulation of plasmacytoid dendritic cell cytokine production
has narrow synonym: inhibition of plasmacytoid dendritic cell cytokine production
has OBO namespace: biological_process
id: GO:0002737
type: Class
subclass of: negative regulation of dendritic cell cytokine production
subclass of: regulation of plasmacytoid dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002212
  some values from: plasmacytoid dendritic cell cytokine production

positive regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has exact synonym: up regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: up-regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: upregulation of plasmacytoid dendritic cell cytokine production
has narrow synonym: activation of plasmacytoid dendritic cell cytokine production
has narrow synonym: stimulation of plasmacytoid dendritic cell cytokine production
has OBO namespace: biological_process
id: GO:0002738
type: Class
subclass of: positive regulation of dendritic cell cytokine production
subclass of: regulation of plasmacytoid dendritic cell cytokine production
subclass of: Restriction
  on property: RO_0002213
  some values from: plasmacytoid dendritic cell cytokine production

regulation of cytokine secretion involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response.
has OBO namespace: biological_process
has related synonym: regulation of cytokine secretion during immune response
id: GO:0002739
type: Class
subclass of: regulation of cytokine production involved in immune response
subclass of: GO_0050707
subclass of: Restriction
  on property: RO_0002211
  some values from: cytokine secretion involved in immune response

negative regulation of cytokine secretion involved in immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response.
has narrow synonym: inhibition of cytokine secretion during immune response
has OBO namespace: biological_process
has related synonym: down regulation of cytokine secretion during immune response
has related synonym: down-regulation of cytokine secretion during immune response
has related synonym: downregulation of cytokine secretion during immune response
has related synonym: negative regulation of cytokine secretion during immune response
id: GO:0002740
type: Class
subclass of: regulation of cytokine secretion involved in immune response
subclass of: GO_0050710
subclass of: Restriction
  on property: RO_0002212
  some values from: cytokine secretion involved in immune response

positive regulation of cytokine secretion involved in immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response.
has narrow synonym: activation of cytokine secretion during immune response
has narrow synonym: stimulation of cytokine secretion during immune response
has OBO namespace: biological_process
has related synonym: positive regulation of cytokine secretion during immune response
has related synonym: up regulation of cytokine secretion during immune response
has related synonym: up-regulation of cytokine secretion during immune response
has related synonym: upregulation of cytokine secretion during immune response
id: GO:0002741
type: Class
subclass of: regulation of cytokine secretion involved in immune response
subclass of: GO_0050715
subclass of: Restriction
  on property: RO_0002213
  some values from: cytokine secretion involved in immune response

regulation of cytokine biosynthetic process involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response.
has OBO namespace: biological_process
has related synonym: regulation of cytokine biosynthetic process during immune response
id: GO:0002742
type: Class
subclass of: regulation of cytokine production involved in immune response
subclass of: GO_0042035
subclass of: Restriction
  on property: RO_0002211
  some values from: cytokine biosynthetic process involved in immune response

negative regulation of cytokine biosynthetic process involved in immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response.
has narrow synonym: inhibition of cytokine biosynthetic process during immune response
has OBO namespace: biological_process
has related synonym: down regulation of cytokine biosynthetic process during immune response
has related synonym: down-regulation of cytokine biosynthetic process during immune response
has related synonym: downregulation of cytokine biosynthetic process during immune response
has related synonym: negative regulation of cytokine biosynthetic process during immune response
id: GO:0002743
type: Class
subclass of: regulation of cytokine biosynthetic process involved in immune response
subclass of: GO_0042036
subclass of: Restriction
  on property: RO_0002212
  some values from: cytokine biosynthetic process involved in immune response

positive regulation of cytokine biosynthetic process involved in immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response.
has narrow synonym: activation of cytokine biosynthetic process during immune response
has narrow synonym: stimulation of cytokine biosynthetic process during immune response
has OBO namespace: biological_process
has related synonym: positive regulation of cytokine biosynthetic process during immune response
has related synonym: up regulation of cytokine biosynthetic process during immune response
has related synonym: up-regulation of cytokine biosynthetic process during immune response
has related synonym: upregulation of cytokine biosynthetic process during immune response
id: GO:0002744
type: Class
subclass of: regulation of cytokine biosynthetic process involved in immune response
subclass of: GO_0042108
subclass of: Restriction
  on property: RO_0002213
  some values from: cytokine biosynthetic process involved in immune response

antigen processing and presentation initiated by receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor.
has OBO namespace: biological_process
id: GO:0002745
type: Class
subclass of: GO_0019882

antigen processing and presentation following pinocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
has OBO namespace: biological_process
id: GO:0002746
type: Class
subclass of: GO_0019882

antigen processing and presentation following phagocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis.
has OBO namespace: biological_process
id: GO:0002747
type: Class
subclass of: GO_0019882

antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR).
has exact synonym: antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen
has exact synonym: antigen processing and presentation initiated by PRR mediated uptake of antigen
has OBO namespace: biological_process
id: GO:0002748
type: Class
subclass of: antigen processing and presentation initiated by receptor mediated uptake of antigen

antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
IAO_0000115: Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR).
has exact synonym: antigen processing and presentation initiated by TLR mediated phagocytosis of antigen
has OBO namespace: biological_process
id: GO:0002749
type: Class
subclass of: antigen processing and presentation following phagocytosis
subclass of: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

antigen processing and presentation following macropinocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis.
has OBO namespace: biological_process
id: GO:0002750
type: Class
subclass of: antigen processing and presentation following pinocytosis

antigen processing and presentation following receptor mediated endocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis.
has OBO namespace: biological_process
id: GO:0002751
type: Class
subclass of: antigen processing and presentation initiated by receptor mediated uptake of antigen

cell surface pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
has exact synonym: cell surface PAMP receptor signaling pathway
has exact synonym: cell surface PRR signaling pathway
has exact synonym: cell surface pathogen receptor signaling pathway
has exact synonym: cell surface pattern recognition receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002752
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway
subclass of: pattern recognition receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located in the cytoplasm. Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
has exact synonym: cytoplasmic PAMP receptor signaling pathway
has exact synonym: cytoplasmic PRR signaling pathway
has exact synonym: cytoplasmic pathogen receptor signaling pathway
has exact synonym: cytoplasmic pattern recognition receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002753
type: Class
subclass of: pattern recognition receptor signaling pathway
subclass of: GO_0030522
subclass of: GO_0035556

intracellular vesicle pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
has exact synonym: intracellular vesicle PAMP receptor signaling pathway
has exact synonym: intracellular vesicle PRR signaling pathway
has exact synonym: intracellular vesicle pathogen receptor signaling pathway
has exact synonym: intracellular vesicle pattern recognition receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002754
type: Class
subclass of: pattern recognition receptor signaling pathway
subclass of: GO_0030522

MyD88-dependent toll-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has db xref: Reactome:REACT_100168
has db xref: Reactome:REACT_101942
has db xref: Reactome:REACT_104035
has db xref: Reactome:REACT_106952
has db xref: Reactome:REACT_107977
has db xref: Reactome:REACT_110031
has db xref: Reactome:REACT_25089
has db xref: Reactome:REACT_27215
has db xref: Reactome:REACT_27254
has db xref: Reactome:REACT_27259
has db xref: Reactome:REACT_28050
has db xref: Reactome:REACT_30270
has db xref: Reactome:REACT_32510
has db xref: Reactome:REACT_34594
has db xref: Reactome:REACT_6788
has db xref: Reactome:REACT_79855
has db xref: Reactome:REACT_80624
has db xref: Reactome:REACT_80969
has db xref: Reactome:REACT_81173
has db xref: Reactome:REACT_81183
has db xref: Reactome:REACT_85347
has db xref: Reactome:REACT_85793
has db xref: Reactome:REACT_88707
has db xref: Reactome:REACT_88909
has db xref: Reactome:REACT_90702
has db xref: Reactome:REACT_92018
has db xref: Reactome:REACT_92143
has db xref: Reactome:REACT_93524
has db xref: Reactome:REACT_93873
has db xref: Reactome:REACT_95154
has db xref: Reactome:REACT_95427
has db xref: Reactome:REACT_95678
has db xref: Reactome:REACT_96158
has db xref: Reactome:REACT_96187
has db xref: Reactome:REACT_96209
has db xref: Reactome:REACT_99530
has db xref: Reactome:REACT_99838
has exact synonym: MyD88-dependent TLR signaling pathway
has exact synonym: MyD88-dependent toll-like receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002755
type: Class
subclass of: toll-like receptor signaling pathway

MyD88-independent toll-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has db xref: Reactome:REACT_100200
has db xref: Reactome:REACT_102299
has db xref: Reactome:REACT_102509
has db xref: Reactome:REACT_102886
has db xref: Reactome:REACT_104655
has db xref: Reactome:REACT_105840
has db xref: Reactome:REACT_105924
has db xref: Reactome:REACT_106037
has db xref: Reactome:REACT_106039
has db xref: Reactome:REACT_106964
has db xref: Reactome:REACT_109458
has db xref: Reactome:REACT_110829
has db xref: Reactome:REACT_110980
has db xref: Reactome:REACT_114143
has db xref: Reactome:REACT_25148
has db xref: Reactome:REACT_28259
has db xref: Reactome:REACT_28395
has db xref: Reactome:REACT_28410
has db xref: Reactome:REACT_28525
has db xref: Reactome:REACT_29826
has db xref: Reactome:REACT_30390
has db xref: Reactome:REACT_31920
has db xref: Reactome:REACT_32587
has db xref: Reactome:REACT_32888
has db xref: Reactome:REACT_33115
has db xref: Reactome:REACT_33276
has db xref: Reactome:REACT_33454
has db xref: Reactome:REACT_33857
has db xref: Reactome:REACT_34578
has db xref: Reactome:REACT_6782
has db xref: Reactome:REACT_6809
has db xref: Reactome:REACT_6898
has db xref: Reactome:REACT_6976
has db xref: Reactome:REACT_70758
has db xref: Reactome:REACT_78892
has db xref: Reactome:REACT_79777
has db xref: Reactome:REACT_81045
has db xref: Reactome:REACT_81308
has db xref: Reactome:REACT_81312
has db xref: Reactome:REACT_82068
has db xref: Reactome:REACT_83083
has db xref: Reactome:REACT_85389
has db xref: Reactome:REACT_85560
has db xref: Reactome:REACT_85813
has db xref: Reactome:REACT_87120
has db xref: Reactome:REACT_88311
has db xref: Reactome:REACT_88396
has db xref: Reactome:REACT_88627
has db xref: Reactome:REACT_89370
has db xref: Reactome:REACT_89942
has db xref: Reactome:REACT_90312
has db xref: Reactome:REACT_91487
has db xref: Reactome:REACT_91606
has db xref: Reactome:REACT_92796
has db xref: Reactome:REACT_93657
has db xref: Reactome:REACT_94894
has db xref: Reactome:REACT_95971
has db xref: Reactome:REACT_96392
has db xref: Reactome:REACT_96482
has db xref: Reactome:REACT_97209
has db xref: Reactome:REACT_98583
has db xref: Reactome:REACT_99022
has db xref: Reactome:REACT_99202
has db xref: Reactome:REACT_99347
has db xref: Reactome:REACT_99643
has exact synonym: MyD88-independent TLR signaling pathway
has exact synonym: MyD88-independent toll-like receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002756
type: Class
subclass of: toll-like receptor signaling pathway

immune response-activating signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response.
has OBO namespace: biological_process
id: GO:0002757
type: Class
subclass of: activation of immune response
subclass of: immune response-regulating signaling pathway

innate immune response-activating signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response.
has OBO namespace: biological_process
id: GO:0002758
type: Class
comment: This term was added by GO_REF:0000022.
subclass of: activation of innate immune response
subclass of: immune response-activating signal transduction

regulation of antimicrobial humoral response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.
has OBO namespace: biological_process
id: GO:0002759
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: regulation of humoral immune response
subclass of: GO_0043900
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0019730

positive regulation of antimicrobial humoral response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.
has exact synonym: up regulation of antimicrobial humoral response
has exact synonym: up-regulation of antimicrobial humoral response
has exact synonym: upregulation of antimicrobial humoral response
has narrow synonym: activation of antimicrobial humoral response
has narrow synonym: stimulation of antimicrobial humoral response
has OBO namespace: biological_process
id: GO:0002760
type: Class
subclass of: regulation of antimicrobial humoral response
subclass of: positive regulation of response to biotic stimulus
subclass of: positive regulation of humoral immune response
subclass of: GO_0043902
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0019730

regulation of myeloid leukocyte differentiation
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.
has OBO namespace: biological_process
id: GO:0002761
type: Class
subclass of: GO_0045637
subclass of: Restriction
  on property: RO_0002211
  some values from: myeloid leukocyte differentiation

negative regulation of myeloid leukocyte differentiation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
has exact synonym: down regulation of myeloid leukocyte differentiation
has exact synonym: down-regulation of myeloid leukocyte differentiation
has exact synonym: downregulation of myeloid leukocyte differentiation
has narrow synonym: inhibition of myeloid leukocyte differentiation
has OBO namespace: biological_process
id: GO:0002762
type: Class
subclass of: regulation of myeloid leukocyte differentiation
subclass of: GO_0045638
subclass of: Restriction
  on property: RO_0002212
  some values from: myeloid leukocyte differentiation

positive regulation of myeloid leukocyte differentiation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
has exact synonym: up regulation of myeloid leukocyte differentiation
has exact synonym: up-regulation of myeloid leukocyte differentiation
has exact synonym: upregulation of myeloid leukocyte differentiation
has narrow synonym: activation of myeloid leukocyte differentiation
has narrow synonym: stimulation of myeloid leukocyte differentiation
has OBO namespace: biological_process
id: GO:0002763
type: Class
subclass of: regulation of myeloid leukocyte differentiation
subclass of: GO_0045639
subclass of: Restriction
  on property: RO_0002213
  some values from: myeloid leukocyte differentiation

immune response-regulating signaling pathway
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.
has exact synonym: immune response-regulating signalling pathway
has OBO namespace: biological_process
id: GO:0002764
type: Class
subclass of: GO_0007165
subclass of: GO_0050776

immune response-inhibiting signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.
has OBO namespace: biological_process
id: GO:0002765
type: Class
subclass of: immune response-regulating signaling pathway

innate immune response-inhibiting signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response.
has OBO namespace: biological_process
id: GO:0002766
type: Class
subclass of: immune response-inhibiting signal transduction

immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.
has exact synonym: immune response-inhibiting cell surface receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002767
type: Class
subclass of: immune response-inhibiting signal transduction
subclass of: immune response-regulating cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
has exact synonym: immune response-regulating cell surface receptor signalling pathway
has OBO namespace: biological_process
id: GO:0002768
type: Class
subclass of: immune response-regulating signaling pathway
subclass of: GO_0007166

natural killer cell inhibitory signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: NK cell inhibitory signaling pathway
has exact synonym: natural killer cell inhibitory signalling pathway
has narrow synonym: inhibitory KIR signaling pathway
has narrow synonym: killer cell inhibitory receptor signaling pathway
has OBO namespace: biological_process
has related synonym: Ly49 inhibitory receptor signaling pathway
id: GO:0002769
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

T cell inhibitory signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: T cell inhibitory signalling pathway
has exact synonym: T lymphocyte inhibitory signaling pathway
has exact synonym: T-cell inhibitory signaling pathway
has exact synonym: T-lymphocyte inhibitory signaling pathway
has OBO namespace: biological_process
id: GO:0002770
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

inhibitory killer cell immunoglobulin-like receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: KIR signaling pathway
has exact synonym: inhibitory killer cell immunoglobulin-like receptor signalling pathway
has exact synonym: killer cell inhibitory receptor signaling pathway
has OBO namespace: biological_process
id: GO:0002771
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

inhibitory C-type lectin receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: inhibitory C-type lectin receptor signalling pathway
has OBO namespace: biological_process
has related synonym: Ly49 inhibitory receptor signaling pathway
id: GO:0002772
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

B cell inhibitory signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: B cell inhibitory signalling pathway
has exact synonym: B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway
has exact synonym: B-cell inhibitory signaling pathway
has OBO namespace: biological_process
id: GO:0002773
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

Fc receptor mediated inhibitory signaling pathway
IAO_0000115: A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
has exact synonym: Fc receptor mediated inhibitory signalling pathway
has exact synonym: Fc-receptor mediated inhibitory signaling pathway
has OBO namespace: biological_process
id: GO:0002774
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

antimicrobial peptide production
IAO_0000115: The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
has OBO namespace: biological_process
id: GO:0002775
type: Class
subclass of: production of molecular mediator of immune response
subclass of: Restriction
  on property: part_of
  some values from: GO_0019730

antimicrobial peptide secretion
IAO_0000115: The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
has OBO namespace: biological_process
id: GO:0002776
type: Class
subclass of: peptide secretion
subclass of: Restriction
  on property: part_of
  some values from: antimicrobial peptide production

antimicrobial peptide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
has OBO namespace: biological_process
id: GO:0002777
type: Class
subclass of: GO_0043043
subclass of: Restriction
  on property: part_of
  some values from: antimicrobial peptide production

antibacterial peptide production
IAO_0000115: The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
has OBO namespace: biological_process
id: GO:0002778
type: Class
subclass of: antimicrobial peptide production
subclass of: Restriction
  on property: part_of
  some values from: GO_0019731

antibacterial peptide secretion
IAO_0000115: The regulated release of an antibacterial peptide from a cell or group of cells.
has OBO namespace: biological_process
id: GO:0002779
type: Class
subclass of: antimicrobial peptide secretion
subclass of: Restriction
  on property: part_of
  some values from: antibacterial peptide production

antibacterial peptide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide.
has OBO namespace: biological_process
id: GO:0002780
type: Class
subclass of: antimicrobial peptide biosynthetic process
subclass of: Restriction
  on property: part_of
  some values from: antibacterial peptide production

antifungal peptide production
IAO_0000115: The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
has OBO namespace: biological_process
id: GO:0002781
type: Class
subclass of: antimicrobial peptide production
subclass of: Restriction
  on property: part_of
  some values from: GO_0019732

antifungal peptide secretion
IAO_0000115: The regulated release of an antifungal peptide from a cell or group of cells.
has OBO namespace: biological_process
id: GO:0002782
type: Class
subclass of: antimicrobial peptide secretion
subclass of: Restriction
  on property: part_of
  some values from: antifungal peptide production

antifungal peptide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antifungal peptide.
has OBO namespace: biological_process
id: GO:0002783
type: Class
subclass of: antimicrobial peptide biosynthetic process
subclass of: Restriction
  on property: part_of
  some values from: antifungal peptide production

regulation of antimicrobial peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.
has OBO namespace: biological_process
id: GO:0002784
type: Class
subclass of: regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial humoral response
subclass of: Restriction
  on property: RO_0002211
  some values from: antimicrobial peptide production

negative regulation of antimicrobial peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.
has exact synonym: down regulation of antimicrobial peptide production
has exact synonym: down-regulation of antimicrobial peptide production
has exact synonym: downregulation of antimicrobial peptide production
has narrow synonym: inhibition of antimicrobial peptide production
has OBO namespace: biological_process
id: GO:0002785
type: Class
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial peptide production
subclass of: Restriction
  on property: RO_0002212
  some values from: antimicrobial peptide production

regulation of antibacterial peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide production.
has OBO namespace: biological_process
id: GO:0002786
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_1900424
subclass of: Restriction
  on property: RO_0002211
  some values from: antibacterial peptide production

negative regulation of antibacterial peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production.
has exact synonym: down regulation of antibacterial peptide production
has exact synonym: down-regulation of antibacterial peptide production
has exact synonym: downregulation of antibacterial peptide production
has narrow synonym: inhibition of antibacterial peptide production
has OBO namespace: biological_process
id: GO:0002787
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antibacterial peptide production
subclass of: Restriction
  on property: RO_0002212
  some values from: antibacterial peptide production

regulation of antifungal peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide production.
has OBO namespace: biological_process
id: GO:0002788
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_1900150
subclass of: Restriction
  on property: RO_0002211
  some values from: antifungal peptide production

negative regulation of antifungal peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production.
has exact synonym: down regulation of antifungal peptide production
has exact synonym: down-regulation of antifungal peptide production
has exact synonym: downregulation of antifungal peptide production
has narrow synonym: inhibition of antifungal peptide production
has OBO namespace: biological_process
id: GO:0002789
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antifungal peptide production
subclass of: Restriction
  on property: RO_0002212
  some values from: antifungal peptide production

peptide secretion
IAO_0000115: The controlled release of a peptide from a cell or group of cells.
has OBO namespace: biological_process
id: GO:0002790
type: Class
subclass of: GO_0015833
subclass of: GO_0046903

regulation of peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of peptide secretion.
has OBO namespace: biological_process
id: GO:0002791
type: Class
subclass of: GO_0051046
subclass of: GO_0090087
subclass of: Restriction
  on property: RO_0002211
  some values from: peptide secretion

negative regulation of peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
has exact synonym: down regulation of peptide secretion
has exact synonym: down-regulation of peptide secretion
has exact synonym: downregulation of peptide secretion
has narrow synonym: inhibition of peptide secretion
has OBO namespace: biological_process
id: GO:0002792
type: Class
subclass of: regulation of peptide secretion
subclass of: GO_0051048
subclass of: Restriction
  on property: RO_0002212
  some values from: peptide secretion

positive regulation of peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peptide secretion.
has exact synonym: up regulation of peptide secretion
has exact synonym: up-regulation of peptide secretion
has exact synonym: upregulation of peptide secretion
has narrow synonym: activation of peptide secretion
has narrow synonym: stimulation of peptide secretion
has OBO namespace: biological_process
id: GO:0002793
type: Class
subclass of: regulation of peptide secretion
subclass of: GO_0051047
subclass of: Restriction
  on property: RO_0002213
  some values from: peptide secretion

regulation of antimicrobial peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.
has OBO namespace: biological_process
id: GO:0002794
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: regulation of peptide secretion
subclass of: Restriction
  on property: RO_0002211
  some values from: antimicrobial peptide secretion

negative regulation of antimicrobial peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.
has exact synonym: down regulation of antimicrobial peptide secretion
has exact synonym: down-regulation of antimicrobial peptide secretion
has exact synonym: downregulation of antimicrobial peptide secretion
has narrow synonym: inhibition of antimicrobial peptide secretion
has OBO namespace: biological_process
id: GO:0002795
type: Class
subclass of: negative regulation of peptide secretion
subclass of: regulation of antimicrobial peptide secretion
subclass of: Restriction
  on property: RO_0002212
  some values from: antimicrobial peptide secretion

positive regulation of antimicrobial peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.
has exact synonym: up regulation of antimicrobial peptide secretion
has exact synonym: up-regulation of antimicrobial peptide secretion
has exact synonym: upregulation of antimicrobial peptide secretion
has narrow synonym: activation of antimicrobial peptide secretion
has narrow synonym: stimulation of antimicrobial peptide secretion
has OBO namespace: biological_process
id: GO:0002796
type: Class
subclass of: positive regulation of peptide secretion
subclass of: regulation of antimicrobial peptide secretion
subclass of: Restriction
  on property: RO_0002213
  some values from: antimicrobial peptide secretion

regulation of antibacterial peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion.
has OBO namespace: biological_process
id: GO:0002797
type: Class
subclass of: regulation of antibacterial peptide production
subclass of: regulation of antimicrobial peptide secretion
subclass of: Restriction
  on property: RO_0002211
  some values from: antibacterial peptide secretion

negative regulation of antibacterial peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion.
has exact synonym: down regulation of antibacterial peptide secretion
has exact synonym: down-regulation of antibacterial peptide secretion
has exact synonym: downregulation of antibacterial peptide secretion
has narrow synonym: inhibition of antibacterial peptide secretion
has OBO namespace: biological_process
id: GO:0002798
type: Class
subclass of: negative regulation of antimicrobial peptide secretion
subclass of: regulation of antibacterial peptide secretion
subclass of: Restriction
  on property: RO_0002212
  some values from: antibacterial peptide secretion

positive regulation of antibacterial peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion.
has exact synonym: up regulation of antibacterial peptide secretion
has exact synonym: up-regulation of antibacterial peptide secretion
has exact synonym: upregulation of antibacterial peptide secretion
has narrow synonym: activation of antibacterial peptide secretion
has narrow synonym: stimulation of antibacterial peptide secretion
has OBO namespace: biological_process
id: GO:0002799
type: Class
subclass of: positive regulation of antimicrobial peptide secretion
subclass of: regulation of antibacterial peptide secretion
subclass of: Restriction
  on property: RO_0002213
  some values from: antibacterial peptide secretion

regulation of antifungal peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide secretion.
has OBO namespace: biological_process
id: GO:0002800
type: Class
subclass of: regulation of antifungal peptide production
subclass of: regulation of antimicrobial peptide secretion
subclass of: Restriction
  on property: RO_0002211
  some values from: antifungal peptide secretion

negative regulation of antifungal peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion.
has exact synonym: down regulation of antifungal peptide secretion
has exact synonym: down-regulation of antifungal peptide secretion
has exact synonym: downregulation of antifungal peptide secretion
has narrow synonym: inhibition of antifungal peptide secretion
has OBO namespace: biological_process
id: GO:0002801
type: Class
subclass of: negative regulation of antimicrobial peptide secretion
subclass of: regulation of antifungal peptide secretion
subclass of: Restriction
  on property: RO_0002212
  some values from: antifungal peptide secretion

positive regulation of antifungal peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion.
has exact synonym: up regulation of antifungal peptide secretion
has exact synonym: up-regulation of antifungal peptide secretion
has exact synonym: upregulation of antifungal peptide secretion
has narrow synonym: activation of antifungal peptide secretion
has narrow synonym: stimulation of antifungal peptide secretion
has OBO namespace: biological_process
id: GO:0002802
type: Class
subclass of: positive regulation of antimicrobial peptide secretion
subclass of: regulation of antifungal peptide secretion
subclass of: Restriction
  on property: RO_0002213
  some values from: antifungal peptide secretion

positive regulation of antibacterial peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production.
has exact synonym: up regulation of antibacterial peptide production
has exact synonym: up-regulation of antibacterial peptide production
has exact synonym: upregulation of antibacterial peptide production
has narrow synonym: activation of antibacterial peptide production
has narrow synonym: stimulation of antibacterial peptide production
has OBO namespace: biological_process
id: GO:0002803
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antibacterial peptide production
subclass of: Restriction
  on property: RO_0002213
  some values from: antibacterial peptide production

positive regulation of antifungal peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.
has exact synonym: up regulation of antifungal peptide production
has exact synonym: up-regulation of antifungal peptide production
has exact synonym: upregulation of antifungal peptide production
has narrow synonym: activation of antifungal peptide production
has narrow synonym: stimulation of antifungal peptide production
has OBO namespace: biological_process
id: GO:0002804
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antifungal peptide production
subclass of: Restriction
  on property: RO_0002213
  some values from: antifungal peptide production

regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has OBO namespace: biological_process
id: GO:0002805
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_0031326
subclass of: GO_0034248
subclass of: Restriction
  on property: RO_0002211
  some values from: antimicrobial peptide biosynthetic process

negative regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has exact synonym: down regulation of antimicrobial peptide biosynthetic process
has exact synonym: down-regulation of antimicrobial peptide biosynthetic process
has exact synonym: downregulation of antimicrobial peptide biosynthetic process
has narrow synonym: inhibition of antimicrobial peptide biosynthetic process
has OBO namespace: biological_process
id: GO:0002806
type: Class
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: GO_0031327
subclass of: GO_0034249
subclass of: Restriction
  on property: RO_0002212
  some values from: antimicrobial peptide biosynthetic process

positive regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has exact synonym: up regulation of antimicrobial peptide biosynthetic process
has exact synonym: up-regulation of antimicrobial peptide biosynthetic process
has exact synonym: upregulation of antimicrobial peptide biosynthetic process
has narrow synonym: activation of antimicrobial peptide biosynthetic process
has narrow synonym: stimulation of antimicrobial peptide biosynthetic process
has OBO namespace: biological_process
id: GO:0002807
type: Class
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: GO_0031328
subclass of: GO_0034250
subclass of: Restriction
  on property: RO_0002213
  some values from: antimicrobial peptide biosynthetic process

regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis.
has OBO namespace: biological_process
id: GO:0002808
type: Class
subclass of: regulation of antibacterial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: Restriction
  on property: RO_0002211
  some values from: antibacterial peptide biosynthetic process

negative regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.
has exact synonym: down regulation of antibacterial peptide biosynthetic process
has exact synonym: down-regulation of antibacterial peptide biosynthetic process
has exact synonym: downregulation of antibacterial peptide biosynthetic process
has narrow synonym: inhibition of antibacterial peptide biosynthetic process
has OBO namespace: biological_process
id: GO:0002809
type: Class
subclass of: negative regulation of antimicrobial peptide biosynthetic process
subclass of: regulation of antibacterial peptide biosynthetic process
subclass of: Restriction
  on property: RO_0002212
  some values from: antibacterial peptide biosynthetic process

regulation of antifungal peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis.
has OBO namespace: biological_process
id: GO:0002810
type: Class
subclass of: regulation of antifungal peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: Restriction
  on property: RO_0002211
  some values from: antifungal peptide biosynthetic process

negative regulation of antifungal peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis.
has exact synonym: down regulation of antifungal peptide biosynthetic process
has exact synonym: down-regulation of antifungal peptide biosynthetic process
has exact synonym: downregulation of antifungal peptide biosynthetic process
has narrow synonym: inhibition of antifungal peptide biosynthetic process
has OBO namespace: biological_process
id: GO:0002811
type: Class
subclass of: negative regulation of antimicrobial peptide biosynthetic process
subclass of: regulation of antifungal peptide biosynthetic process
subclass of: Restriction
  on property: RO_0002212
  some values from: antifungal peptide biosynthetic process

biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria.
has OBO namespace: biological_process
id: GO:0002812
type: Class
subclass of: antibacterial peptide biosynthetic process
subclass of: Restriction
  on property: part_of
  some values from: GO_0050829

regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
has OBO namespace: biological_process
id: GO:0002813
type: Class
subclass of: regulation of antibacterial peptide biosynthetic process
subclass of: Restriction
  on property: RO_0002211
  some values from: biosynthetic process of antibacterial peptides active against Gram-negative bacteria

negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
has exact synonym: down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has exact synonym: down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has exact synonym: downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has narrow synonym: inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has OBO namespace: biological_process
id: GO:0002814
type: Class
subclass of: negative regulation of antibacterial peptide biosynthetic process
subclass of: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
subclass of: Restriction
  on property: RO_0002212
  some values from: biosynthetic process of antibacterial peptides active against Gram-negative bacteria

biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria.
has OBO namespace: biological_process
id: GO:0002815
type: Class
subclass of: antibacterial peptide biosynthetic process
subclass of: Restriction
  on property: part_of
  some values from: GO_0050830

regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
has OBO namespace: biological_process
id: GO:0002816
type: Class
subclass of: regulation of antibacterial peptide biosynthetic process
subclass of: Restriction
  on property: RO_0002211
  some values from: biosynthetic process of antibacterial peptides active against Gram-positive bacteria

negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
has exact synonym: down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has exact synonym: down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has exact synonym: downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has narrow synonym: inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has OBO namespace: biological_process
id: GO:0002817
type: Class
subclass of: negative regulation of antibacterial peptide biosynthetic process
subclass of: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
subclass of: Restriction
  on property: RO_0002212
  some values from: biosynthetic process of antibacterial peptides active against Gram-positive bacteria

intracellular defense response
IAO_0000115: A physiological defense response which occurs intracellularly.
has exact synonym: intracellular defence response
has OBO namespace: biological_process
id: GO:0002818
type: Class
subclass of: GO_0006968
subclass of: GO_0033554

regulation of adaptive immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an adaptive immune response.
has OBO namespace: biological_process
id: GO:0002819
type: Class
subclass of: GO_0050776
subclass of: Restriction
  on property: RO_0002211
  some values from: adaptive immune response

negative regulation of adaptive immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
has exact synonym: down regulation of adaptive immune response
has exact synonym: down-regulation of adaptive immune response
has exact synonym: downregulation of adaptive immune response
has narrow synonym: inhibition of adaptive immune response
has OBO namespace: biological_process
id: GO:0002820
type: Class
subclass of: regulation of adaptive immune response
subclass of: GO_0050777
subclass of: Restriction
  on property: RO_0002212
  some values from: adaptive immune response

positive regulation of adaptive immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
has exact synonym: up regulation of adaptive immune response
has exact synonym: up-regulation of adaptive immune response
has exact synonym: upregulation of adaptive immune response
has narrow synonym: activation of adaptive immune response
has narrow synonym: stimulation of adaptive immune response
has OBO namespace: biological_process
id: GO:0002821
type: Class
subclass of: regulation of adaptive immune response
subclass of: GO_0050778
subclass of: Restriction
  on property: RO_0002213
  some values from: adaptive immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
has OBO namespace: biological_process
id: GO:0002822
type: Class
subclass of: regulation of adaptive immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
has OBO namespace: biological_process
id: GO:0002823
type: Class
subclass of: negative regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002212
  some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
has OBO namespace: biological_process
id: GO:0002824
type: Class
subclass of: positive regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002213
  some values from: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

regulation of T-helper 1 type immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response.
has OBO namespace: biological_process
id: GO:0002825
type: Class
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0042088

negative regulation of T-helper 1 type immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.
has exact synonym: down regulation of T-helper 1 type immune response
has exact synonym: down-regulation of T-helper 1 type immune response
has exact synonym: downregulation of T-helper 1 type immune response
has narrow synonym: inhibition of T-helper 1 type immune response
has OBO namespace: biological_process
id: GO:0002826
type: Class
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of T-helper 1 type immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0042088

positive regulation of T-helper 1 type immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
has exact synonym: up regulation of T-helper 1 type immune response
has exact synonym: up-regulation of T-helper 1 type immune response
has exact synonym: upregulation of T-helper 1 type immune response
has narrow synonym: activation of T-helper 1 type immune response
has narrow synonym: stimulation of T-helper 1 type immune response
has OBO namespace: biological_process
id: GO:0002827
type: Class
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of T-helper 1 type immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0042088

regulation of type 2 immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a type 2 immune response.
has narrow synonym: regulation of T-helper 2 type immune response
has narrow synonym: regulation of Th2 immune response
has OBO namespace: biological_process
id: GO:0002828
type: Class
subclass of: GO_0050776
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0042092

negative regulation of type 2 immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
has exact synonym: down regulation of type 2 immune response
has exact synonym: down-regulation of type 2 immune response
has exact synonym: downregulation of type 2 immune response
has narrow synonym: inhibition of type 2 immune response
has narrow synonym: negative regulation of T-helper 2 type immune response
has narrow synonym: negative regulation of Th2 immune response
has OBO namespace: biological_process
id: GO:0002829
type: Class
subclass of: regulation of type 2 immune response
subclass of: GO_0050777
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0042092

positive regulation of type 2 immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
has exact synonym: up regulation of type 2 immune response
has exact synonym: up-regulation of type 2 immune response
has exact synonym: upregulation of type 2 immune response
has narrow synonym: activation of type 2 immune response
has narrow synonym: positive regulation of T-helper 2 type immune response
has narrow synonym: positive regulation of Th2 immune response
has narrow synonym: stimulation of type 2 immune response
has OBO namespace: biological_process
id: GO:0002830
type: Class
subclass of: regulation of type 2 immune response
subclass of: GO_0050778
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0042092

regulation of response to biotic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
has OBO namespace: biological_process
id: GO:0002831
type: Class
subclass of: GO_0048583
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0009607

negative regulation of response to biotic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
has exact synonym: down regulation of response to biotic stimulus
has exact synonym: down-regulation of response to biotic stimulus
has exact synonym: downregulation of response to biotic stimulus
has narrow synonym: inhibition of response to biotic stimulus
has OBO namespace: biological_process
id: GO:0002832
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: GO_0048585
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0009607

positive regulation of response to biotic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
has exact synonym: up regulation of response to biotic stimulus
has exact synonym: up-regulation of response to biotic stimulus
has exact synonym: upregulation of response to biotic stimulus
has narrow synonym: activation of response to biotic stimulus
has narrow synonym: stimulation of response to biotic stimulus
has OBO namespace: biological_process
id: GO:0002833
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: GO_0048584
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0009607

regulation of response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of a response to tumor cell.
has exact synonym: regulation of response to tumour cell
has OBO namespace: biological_process
id: GO:0002834
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: Restriction
  on property: RO_0002211
  some values from: response to tumor cell

negative regulation of response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell.
has exact synonym: down regulation of response to tumor cell
has exact synonym: down-regulation of response to tumor cell
has exact synonym: downregulation of response to tumor cell
has exact synonym: negative regulation of response to tumour cell
has narrow synonym: inhibition of response to tumor cell
has OBO namespace: biological_process
id: GO:0002835
type: Class
subclass of: negative regulation of response to biotic stimulus
subclass of: regulation of response to tumor cell
subclass of: Restriction
  on property: RO_0002212
  some values from: response to tumor cell

positive regulation of response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a response to tumor cell.
has exact synonym: positive regulation of response to tumour cell
has exact synonym: up regulation of response to tumor cell
has exact synonym: up-regulation of response to tumor cell
has exact synonym: upregulation of response to tumor cell
has narrow synonym: activation of response to tumor cell
has narrow synonym: stimulation of response to tumor cell
has OBO namespace: biological_process
id: GO:0002836
type: Class
subclass of: positive regulation of response to biotic stimulus
subclass of: regulation of response to tumor cell
subclass of: Restriction
  on property: RO_0002213
  some values from: response to tumor cell

regulation of immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: regulation of immune response to tumour cell
has OBO namespace: biological_process
id: GO:0002837
type: Class
subclass of: regulation of response to tumor cell
subclass of: GO_0050776
subclass of: Restriction
  on property: RO_0002211
  some values from: immune response to tumor cell

negative regulation of immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: down regulation of immune response to tumor cell
has exact synonym: down-regulation of immune response to tumor cell
has exact synonym: downregulation of immune response to tumor cell
has exact synonym: negative regulation of immune response to tumour cell
has narrow synonym: inhibition of immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002838
type: Class
subclass of: negative regulation of response to tumor cell
subclass of: regulation of immune response to tumor cell
subclass of: GO_0050777
subclass of: Restriction
  on property: RO_0002212
  some values from: immune response to tumor cell

positive regulation of immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: positive regulation of immune response to tumour cell
has exact synonym: up regulation of immune response to tumor cell
has exact synonym: up-regulation of immune response to tumor cell
has exact synonym: upregulation of immune response to tumor cell
has narrow synonym: activation of immune response to tumor cell
has narrow synonym: stimulation of immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002839
type: Class
subclass of: positive regulation of response to tumor cell
subclass of: regulation of immune response to tumor cell
subclass of: GO_0050778
subclass of: Restriction
  on property: RO_0002213
  some values from: immune response to tumor cell

regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: regulation of T cell mediated immune response to tumour cell
has exact synonym: regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: regulation of T-cell mediated immune response to tumor cell
has exact synonym: regulation of T-lymphocyte mediated immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002840
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of immune response to tumor cell
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell mediated immune response to tumor cell

negative regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: down regulation of T cell mediated immune response to tumor cell
has exact synonym: down-regulation of T cell mediated immune response to tumor cell
has exact synonym: downregulation of T cell mediated immune response to tumor cell
has exact synonym: negative regulation of T cell mediated immune response to tumour cell
has exact synonym: negative regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: negative regulation of T-cell mediated immune response to tumor cell
has exact synonym: negative regulation of T-lymphocyte mediated immune response to tumor cell
has narrow synonym: inhibition of T cell mediated immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002841
type: Class
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of T cell mediated immune response to tumor cell
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell mediated immune response to tumor cell

positive regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: positive regulation of T cell mediated immune response to tumour cell
has exact synonym: positive regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: positive regulation of T-cell mediated immune response to tumor cell
has exact synonym: positive regulation of T-lymphocyte mediated immune response to tumor cell
has exact synonym: up regulation of T cell mediated immune response to tumor cell
has exact synonym: up-regulation of T cell mediated immune response to tumor cell
has exact synonym: upregulation of T cell mediated immune response to tumor cell
has narrow synonym: activation of T cell mediated immune response to tumor cell
has narrow synonym: stimulation of T cell mediated immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002842
type: Class
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of T cell mediated immune response to tumor cell
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell mediated immune response to tumor cell

regulation of tolerance induction to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: regulation of tolerance induction to tumour cell
has OBO namespace: biological_process
id: GO:0002843
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of immune response to tumor cell
subclass of: Restriction
  on property: RO_0002211
  some values from: tolerance induction to tumor cell

negative regulation of tolerance induction to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: down regulation of tolerance induction to tumor cell
has exact synonym: down-regulation of tolerance induction to tumor cell
has exact synonym: downregulation of tolerance induction to tumor cell
has exact synonym: negative regulation of tolerance induction to tumour cell
has narrow synonym: inhibition of tolerance induction to tumor cell
has OBO namespace: biological_process
id: GO:0002844
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
subclass of: Restriction
  on property: RO_0002212
  some values from: tolerance induction to tumor cell

positive regulation of tolerance induction to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: positive regulation of tolerance induction to tumour cell
has exact synonym: up regulation of tolerance induction to tumor cell
has exact synonym: up-regulation of tolerance induction to tumor cell
has exact synonym: upregulation of tolerance induction to tumor cell
has narrow synonym: activation of tolerance induction to tumor cell
has narrow synonym: stimulation of tolerance induction to tumor cell
has OBO namespace: biological_process
id: GO:0002845
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
subclass of: Restriction
  on property: RO_0002213
  some values from: tolerance induction to tumor cell

regulation of T cell tolerance induction to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has OBO namespace: biological_process
id: GO:0002846
type: Class
subclass of: regulation of T cell mediated immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
subclass of: regulation of peripheral T cell tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell tolerance induction to tumor cell

negative regulation of T cell tolerance induction to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has exact synonym: down regulation of T cell tolerance induction to tumor cell
has exact synonym: down-regulation of T cell tolerance induction to tumor cell
has exact synonym: downregulation of T cell tolerance induction to tumor cell
has narrow synonym: inhibition of T cell tolerance induction to tumor cell
has OBO namespace: biological_process
id: GO:0002847
type: Class
subclass of: negative regulation of T cell mediated immune response to tumor cell
subclass of: negative regulation of tolerance induction to tumor cell
subclass of: regulation of T cell tolerance induction to tumor cell
subclass of: negative regulation of peripheral T cell tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell tolerance induction to tumor cell

positive regulation of T cell tolerance induction to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has exact synonym: up regulation of T cell tolerance induction to tumor cell
has exact synonym: up-regulation of T cell tolerance induction to tumor cell
has exact synonym: upregulation of T cell tolerance induction to tumor cell
has narrow synonym: activation of T cell tolerance induction to tumor cell
has narrow synonym: stimulation of T cell tolerance induction to tumor cell
has OBO namespace: biological_process
id: GO:0002848
type: Class
subclass of: positive regulation of T cell mediated immune response to tumor cell
subclass of: positive regulation of tolerance induction to tumor cell
subclass of: regulation of T cell tolerance induction to tumor cell
subclass of: positive regulation of peripheral T cell tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell tolerance induction to tumor cell

regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction.
has OBO namespace: biological_process
id: GO:0002849
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of T cell tolerance induction
subclass of: regulation of T cell mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: peripheral T cell tolerance induction

negative regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction.
has exact synonym: down regulation of peripheral T cell tolerance induction
has exact synonym: down-regulation of peripheral T cell tolerance induction
has exact synonym: downregulation of peripheral T cell tolerance induction
has narrow synonym: inhibition of peripheral T cell tolerance induction
has OBO namespace: biological_process
id: GO:0002850
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of T cell tolerance induction
subclass of: negative regulation of T cell mediated immunity
subclass of: regulation of peripheral T cell tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: peripheral T cell tolerance induction

positive regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.
has exact synonym: up regulation of peripheral T cell tolerance induction
has exact synonym: up-regulation of peripheral T cell tolerance induction
has exact synonym: upregulation of peripheral T cell tolerance induction
has narrow synonym: activation of peripheral T cell tolerance induction
has narrow synonym: stimulation of peripheral T cell tolerance induction
has OBO namespace: biological_process
id: GO:0002851
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of T cell tolerance induction
subclass of: positive regulation of T cell mediated immunity
subclass of: regulation of peripheral T cell tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: peripheral T cell tolerance induction

regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has OBO namespace: biological_process
id: GO:0002852
type: Class
subclass of: regulation of T cell mediated cytotoxicity
subclass of: regulation of T cell mediated immune response to tumor cell
subclass of: Restriction
  on property: RO_0002211
  some values from: T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has exact synonym: down regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down-regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: downregulation of T cell mediated cytotoxicity directed against tumor cell target
has narrow synonym: inhibition of T cell mediated cytotoxicity directed against tumor cell target
has OBO namespace: biological_process
id: GO:0002853
type: Class
subclass of: negative regulation of T cell mediated cytotoxicity
subclass of: negative regulation of T cell mediated immune response to tumor cell
subclass of: regulation of T cell mediated cytotoxicity directed against tumor cell target
subclass of: Restriction
  on property: RO_0002212
  some values from: T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has exact synonym: up regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up-regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: upregulation of T cell mediated cytotoxicity directed against tumor cell target
has narrow synonym: activation of T cell mediated cytotoxicity directed against tumor cell target
has narrow synonym: stimulation of T cell mediated cytotoxicity directed against tumor cell target
has OBO namespace: biological_process
id: GO:0002854
type: Class
subclass of: positive regulation of T cell mediated cytotoxicity
subclass of: positive regulation of T cell mediated immune response to tumor cell
subclass of: regulation of T cell mediated cytotoxicity directed against tumor cell target
subclass of: Restriction
  on property: RO_0002213
  some values from: T cell mediated cytotoxicity directed against tumor cell target

regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has OBO namespace: biological_process
id: GO:0002855
type: Class
subclass of: regulation of natural killer cell mediated immunity
subclass of: regulation of immune response to tumor cell
subclass of: Restriction
  on property: RO_0002211
  some values from: natural killer cell mediated immune response to tumor cell

negative regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has exact synonym: down regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: down-regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: downregulation of natural killer cell mediated immune response to tumor cell
has narrow synonym: inhibition of natural killer cell mediated immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002856
type: Class
subclass of: negative regulation of natural killer cell mediated immunity
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of natural killer cell mediated immune response to tumor cell
subclass of: Restriction
  on property: RO_0002212
  some values from: natural killer cell mediated immune response to tumor cell

positive regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has exact synonym: up regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: up-regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: upregulation of natural killer cell mediated immune response to tumor cell
has narrow synonym: activation of natural killer cell mediated immune response to tumor cell
has narrow synonym: stimulation of natural killer cell mediated immune response to tumor cell
has OBO namespace: biological_process
id: GO:0002857
type: Class
subclass of: positive regulation of natural killer cell mediated immunity
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of natural killer cell mediated immune response to tumor cell
subclass of: Restriction
  on property: RO_0002213
  some values from: natural killer cell mediated immune response to tumor cell

regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has OBO namespace: biological_process
id: GO:0002858
type: Class
subclass of: regulation of natural killer cell mediated immune response to tumor cell
subclass of: GO_0042269
subclass of: Restriction
  on property: RO_0002211
  some values from: natural killer cell mediated cytotoxicity directed against tumor cell target

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has exact synonym: down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has narrow synonym: inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target
has OBO namespace: biological_process
id: GO:0002859
type: Class
subclass of: negative regulation of natural killer cell mediated immune response to tumor cell
subclass of: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
subclass of: GO_0045953
subclass of: Restriction
  on property: RO_0002212
  some values from: natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has exact synonym: up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has narrow synonym: activation of natural killer cell mediated cytotoxicity directed against tumor cell target
has narrow synonym: stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has OBO namespace: biological_process
id: GO:0002860
type: Class
subclass of: positive regulation of natural killer cell mediated immune response to tumor cell
subclass of: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
subclass of: GO_0045954
subclass of: Restriction
  on property: RO_0002213
  some values from: natural killer cell mediated cytotoxicity directed against tumor cell target

regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has OBO namespace: biological_process
id: GO:0002861
type: Class
subclass of: GO_0050727
subclass of: GO_0050776
subclass of: Restriction
  on property: RO_0002211
  some values from: inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has exact synonym: down regulation of inflammatory response to antigenic stimulus
has exact synonym: down-regulation of inflammatory response to antigenic stimulus
has exact synonym: downregulation of inflammatory response to antigenic stimulus
has narrow synonym: inhibition of inflammatory response to antigenic stimulus
has OBO namespace: biological_process
id: GO:0002862
type: Class
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050728
subclass of: GO_0050777
subclass of: Restriction
  on property: RO_0002212
  some values from: inflammatory response to antigenic stimulus

positive regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has exact synonym: up regulation of inflammatory response to antigenic stimulus
has exact synonym: up-regulation of inflammatory response to antigenic stimulus
has exact synonym: upregulation of inflammatory response to antigenic stimulus
has narrow synonym: activation of inflammatory response to antigenic stimulus
has narrow synonym: stimulation of inflammatory response to antigenic stimulus
has OBO namespace: biological_process
id: GO:0002863
type: Class
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050729
subclass of: GO_0050778
subclass of: Restriction
  on property: RO_0002213
  some values from: inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has OBO namespace: biological_process
id: GO:0002864
type: Class
subclass of: regulation of acute inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002211
  some values from: acute inflammatory response to antigenic stimulus

negative regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has exact synonym: down regulation of acute inflammatory response to antigenic stimulus
has exact synonym: down-regulation of acute inflammatory response to antigenic stimulus
has exact synonym: downregulation of acute inflammatory response to antigenic stimulus
has narrow synonym: inhibition of acute inflammatory response to antigenic stimulus
has OBO namespace: biological_process
id: GO:0002865
type: Class
subclass of: negative regulation of acute inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002212
  some values from: acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has exact synonym: up regulation of acute inflammatory response to antigenic stimulus
has exact synonym: up-regulation of acute inflammatory response to antigenic stimulus
has exact synonym: upregulation of acute inflammatory response to antigenic stimulus
has narrow synonym: activation of acute inflammatory response to antigenic stimulus
has narrow synonym: stimulation of acute inflammatory response to antigenic stimulus
has OBO namespace: biological_process
id: GO:0002866
type: Class
subclass of: positive regulation of acute inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002213
  some values from: acute inflammatory response to antigenic stimulus

regulation of B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell deletion.
has exact synonym: regulation of B lymphocyte deletion
has exact synonym: regulation of B-cell deletion
has exact synonym: regulation of B-lymphocyte deletion
has OBO namespace: biological_process
id: GO:0002867
type: Class
subclass of: regulation of B cell tolerance induction
subclass of: regulation of B cell apoptotic process
subclass of: Restriction
  on property: RO_0002211
  some values from: B cell deletion

negative regulation of B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion.
has exact synonym: down regulation of B cell deletion
has exact synonym: down-regulation of B cell deletion
has exact synonym: downregulation of B cell deletion
has exact synonym: negative regulation of B lymphocyte deletion
has exact synonym: negative regulation of B-cell deletion
has exact synonym: negative regulation of B-lymphocyte deletion
has narrow synonym: inhibition of B cell deletion
has OBO namespace: biological_process
id: GO:0002868
type: Class
subclass of: regulation of acute inflammatory response
subclass of: regulation of B cell deletion
subclass of: negative regulation of B cell apoptotic process
subclass of: Restriction
  on property: RO_0002212
  some values from: B cell deletion

positive regulation of B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell deletion.
has exact synonym: positive regulation of B lymphocyte deletion
has exact synonym: positive regulation of B-cell deletion
has exact synonym: positive regulation of B-lymphocyte deletion
has exact synonym: up regulation of B cell deletion
has exact synonym: up-regulation of B cell deletion
has exact synonym: upregulation of B cell deletion
has narrow synonym: activation of B cell deletion
has narrow synonym: stimulation of B cell deletion
has OBO namespace: biological_process
id: GO:0002869
type: Class
subclass of: regulation of acute inflammatory response
subclass of: regulation of B cell deletion
subclass of: positive regulation of B cell apoptotic process
subclass of: Restriction
  on property: RO_0002213
  some values from: B cell deletion

T cell anergy
IAO_0000115: Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction.
has exact synonym: T lymphocyte anergy
has exact synonym: T-cell anergy
has exact synonym: T-lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002870
type: Class
subclass of: lymphocyte anergy
subclass of: T cell tolerance induction

regulation of natural killer cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: regulation of NK cell tolerance induction
has OBO namespace: biological_process
id: GO:0002871
type: Class
subclass of: regulation of tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: natural killer cell tolerance induction

negative regulation of natural killer cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: down regulation of natural killer cell tolerance induction
has exact synonym: down-regulation of natural killer cell tolerance induction
has exact synonym: downregulation of natural killer cell tolerance induction
has exact synonym: negative regulation of NK cell tolerance induction
has narrow synonym: inhibition of natural killer cell tolerance induction
has OBO namespace: biological_process
id: GO:0002872
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of natural killer cell tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: natural killer cell tolerance induction

positive regulation of natural killer cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: positive regulation of NK cell tolerance induction
has exact synonym: up regulation of natural killer cell tolerance induction
has exact synonym: up-regulation of natural killer cell tolerance induction
has exact synonym: upregulation of natural killer cell tolerance induction
has narrow synonym: activation of natural killer cell tolerance induction
has narrow synonym: stimulation of natural killer cell tolerance induction
has OBO namespace: biological_process
id: GO:0002873
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of natural killer cell tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: natural killer cell tolerance induction

regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has OBO namespace: biological_process
id: GO:0002874
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002211
  some values from: chronic inflammatory response to antigenic stimulus

negative regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has exact synonym: down regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: down-regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: downregulation of chronic inflammatory response to antigenic stimulus
has narrow synonym: inhibition of chronic inflammatory response to antigenic stimulus
has OBO namespace: biological_process
id: GO:0002875
type: Class
subclass of: negative regulation of chronic inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of chronic inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002212
  some values from: chronic inflammatory response to antigenic stimulus

positive regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has exact synonym: up regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: up-regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: upregulation of chronic inflammatory response to antigenic stimulus
has narrow synonym: activation of chronic inflammatory response to antigenic stimulus
has narrow synonym: stimulation of chronic inflammatory response to antigenic stimulus
has OBO namespace: biological_process
id: GO:0002876
type: Class
subclass of: positive regulation of chronic inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of chronic inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002213
  some values from: chronic inflammatory response to antigenic stimulus

regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has OBO namespace: biological_process
id: GO:0002877
type: Class
subclass of: regulation of acute inflammatory response
subclass of: Restriction
  on property: RO_0002211
  some values from: acute inflammatory response to non-antigenic stimulus

negative regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has exact synonym: down regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: down-regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: downregulation of acute inflammatory response to non-antigenic stimulus
has narrow synonym: inhibition of acute inflammatory response to non-antigenic stimulus
has OBO namespace: biological_process
id: GO:0002878
type: Class
subclass of: negative regulation of acute inflammatory response
subclass of: regulation of acute inflammatory response to non-antigenic stimulus
subclass of: Restriction
  on property: RO_0002212
  some values from: acute inflammatory response to non-antigenic stimulus

positive regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has exact synonym: up regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: up-regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: upregulation of acute inflammatory response to non-antigenic stimulus
has narrow synonym: activation of acute inflammatory response to non-antigenic stimulus
has narrow synonym: stimulation of acute inflammatory response to non-antigenic stimulus
has OBO namespace: biological_process
id: GO:0002879
type: Class
subclass of: positive regulation of acute inflammatory response
subclass of: regulation of acute inflammatory response to non-antigenic stimulus
subclass of: Restriction
  on property: RO_0002213
  some values from: acute inflammatory response to non-antigenic stimulus

regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has OBO namespace: biological_process
id: GO:0002880
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: Restriction
  on property: RO_0002211
  some values from: chronic inflammatory response to non-antigenic stimulus

negative regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has exact synonym: down regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: down-regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: downregulation of chronic inflammatory response to non-antigenic stimulus
has narrow synonym: inhibition of chronic inflammatory response to non-antigenic stimulus
has OBO namespace: biological_process
id: GO:0002881
type: Class
subclass of: negative regulation of chronic inflammatory response
subclass of: regulation of chronic inflammatory response to non-antigenic stimulus
subclass of: Restriction
  on property: RO_0002212
  some values from: chronic inflammatory response to non-antigenic stimulus

positive regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has exact synonym: up regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: up-regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: upregulation of chronic inflammatory response to non-antigenic stimulus
has narrow synonym: activation of chronic inflammatory response to non-antigenic stimulus
has narrow synonym: stimulation of chronic inflammatory response to non-antigenic stimulus
has OBO namespace: biological_process
id: GO:0002882
type: Class
subclass of: positive regulation of chronic inflammatory response
subclass of: regulation of chronic inflammatory response to non-antigenic stimulus
subclass of: Restriction
  on property: RO_0002213
  some values from: chronic inflammatory response to non-antigenic stimulus

regulation of hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of hypersensitivity.
has OBO namespace: biological_process
id: GO:0002883
type: Class
subclass of: regulation of acute inflammatory response to antigenic stimulus
subclass of: Restriction
  on property: RO_0002211
  some values from: hypersensitivity

negative regulation of hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.
has exact synonym: down regulation of hypersensitivity
has exact synonym: down-regulation of hypersensitivity
has exact synonym: downregulation of hypersensitivity
has narrow synonym: inhibition of hypersensitivity
has OBO namespace: biological_process
id: GO:0002884
type: Class
subclass of: negative regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity
subclass of: Restriction
  on property: RO_0002212
  some values from: hypersensitivity

positive regulation of hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.
has exact synonym: up regulation of hypersensitivity
has exact synonym: up-regulation of hypersensitivity
has exact synonym: upregulation of hypersensitivity
has narrow synonym: activation of hypersensitivity
has narrow synonym: stimulation of hypersensitivity
has OBO namespace: biological_process
id: GO:0002885
type: Class
subclass of: positive regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity
subclass of: Restriction
  on property: RO_0002213
  some values from: hypersensitivity

regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has OBO namespace: biological_process
id: GO:0002886
type: Class
subclass of: regulation of leukocyte mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: myeloid leukocyte mediated immunity

negative regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has exact synonym: down regulation of myeloid leukocyte mediated immunity
has exact synonym: down-regulation of myeloid leukocyte mediated immunity
has exact synonym: downregulation of myeloid leukocyte mediated immunity
has narrow synonym: inhibition of myeloid leukocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002887
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: Restriction
  on property: RO_0002212
  some values from: myeloid leukocyte mediated immunity

positive regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has exact synonym: up regulation of myeloid leukocyte mediated immunity
has exact synonym: up-regulation of myeloid leukocyte mediated immunity
has exact synonym: upregulation of myeloid leukocyte mediated immunity
has narrow synonym: activation of myeloid leukocyte mediated immunity
has narrow synonym: stimulation of myeloid leukocyte mediated immunity
has OBO namespace: biological_process
id: GO:0002888
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: Restriction
  on property: RO_0002213
  some values from: myeloid leukocyte mediated immunity

regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.
has OBO namespace: biological_process
id: GO:0002889
type: Class
subclass of: regulation of B cell mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0016064

negative regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.
has exact synonym: down regulation of immunoglobulin mediated immune response
has exact synonym: down-regulation of immunoglobulin mediated immune response
has exact synonym: downregulation of immunoglobulin mediated immune response
has narrow synonym: inhibition of immunoglobulin mediated immune response
has OBO namespace: biological_process
id: GO:0002890
type: Class
subclass of: negative regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0016064

positive regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
has exact synonym: up regulation of immunoglobulin mediated immune response
has exact synonym: up-regulation of immunoglobulin mediated immune response
has exact synonym: upregulation of immunoglobulin mediated immune response
has narrow synonym: activation of immunoglobulin mediated immune response
has narrow synonym: stimulation of immunoglobulin mediated immune response
has OBO namespace: biological_process
id: GO:0002891
type: Class
subclass of: positive regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0016064

regulation of type II hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type II hypersensitivity.
has OBO namespace: biological_process
id: GO:0002892
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: type II hypersensitivity

negative regulation of type II hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.
has exact synonym: down regulation of type II hypersensitivity
has exact synonym: down-regulation of type II hypersensitivity
has exact synonym: downregulation of type II hypersensitivity
has narrow synonym: inhibition of type II hypersensitivity
has OBO namespace: biological_process
id: GO:0002893
type: Class
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002212
  some values from: type II hypersensitivity

positive regulation of type II hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.
has exact synonym: up regulation of type II hypersensitivity
has exact synonym: up-regulation of type II hypersensitivity
has exact synonym: upregulation of type II hypersensitivity
has narrow synonym: activation of type II hypersensitivity
has narrow synonym: stimulation of type II hypersensitivity
has OBO namespace: biological_process
id: GO:0002894
type: Class
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity
subclass of: Restriction
  on property: RO_0002213
  some values from: type II hypersensitivity

regulation of central B cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell tolerance induction.
has OBO namespace: biological_process
id: GO:0002895
type: Class
subclass of: regulation of central tolerance induction
subclass of: regulation of B cell tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: central B cell tolerance induction

negative regulation of central B cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction.
has exact synonym: down regulation of central B cell tolerance induction
has exact synonym: down-regulation of central B cell tolerance induction
has exact synonym: downregulation of central B cell tolerance induction
has narrow synonym: inhibition of central B cell tolerance induction
has OBO namespace: biological_process
id: GO:0002896
type: Class
subclass of: negative regulation of central tolerance induction
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of central B cell tolerance induction
subclass of: Restriction
  on property: RO_0002212
  some values from: central B cell tolerance induction

positive regulation of central B cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction.
has exact synonym: up regulation of central B cell tolerance induction
has exact synonym: up-regulation of central B cell tolerance induction
has exact synonym: upregulation of central B cell tolerance induction
has narrow synonym: activation of central B cell tolerance induction
has narrow synonym: stimulation of central B cell tolerance induction
has OBO namespace: biological_process
id: GO:0002897
type: Class
subclass of: positive regulation of central tolerance induction
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of central B cell tolerance induction
subclass of: Restriction
  on property: RO_0002213
  some values from: central B cell tolerance induction

regulation of central B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell deletion.
has OBO namespace: biological_process
id: GO:0002898
type: Class
subclass of: regulation of B cell deletion
subclass of: regulation of central B cell tolerance induction
subclass of: GO_0045577
subclass of: Restriction
  on property: RO_0002211
  some values from: central B cell deletion

negative regulation of central B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion.
has exact synonym: down regulation of central B cell deletion
has exact synonym: down-regulation of central B cell deletion
has exact synonym: downregulation of central B cell deletion
has narrow synonym: inhibition of central B cell deletion
has OBO namespace: biological_process
id: GO:0002899
type: Class
subclass of: negative regulation of B cell deletion
subclass of: regulation of central B cell deletion
subclass of: Restriction
  on property: RO_0002212
  some values from: central B cell deletion

positive regulation of central B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell deletion.
has exact synonym: up regulation of central B cell deletion
has exact synonym: up-regulation of central B cell deletion
has exact synonym: upregulation of central B cell deletion
has narrow synonym: activation of central B cell deletion
has narrow synonym: stimulation of central B cell deletion
has OBO namespace: biological_process
id: GO:0002900
type: Class
subclass of: positive regulation of B cell deletion
subclass of: regulation of central B cell deletion
subclass of: Restriction
  on property: RO_0002213
  some values from: central B cell deletion

mature B cell apoptotic process
IAO_0000115: Any apoptotic process in a B cell that is mature, having left the bone marrow.
has exact synonym: apoptosis of mature B cells
has exact synonym: apoptosis of mature B lymphocytes
has exact synonym: apoptosis of mature B-cells
has exact synonym: apoptosis of mature B-lymphocytes
has exact synonym: mature B cell programmed cell death by apoptosis
has exact synonym: mature B lymphocyte apoptosis
has exact synonym: mature B lymphocyte programmed cell death by apoptosis
has exact synonym: mature B-cell apoptosis
has exact synonym: mature B-cell programmed cell death by apoptosis
has exact synonym: mature B-lymphocyte apoptosis
has exact synonym: mature B-lymphocyte programmed cell death by apoptosis
has exact synonym: programmed cell death of mature B cells by apoptosis
has exact synonym: programmed cell death of mature B lymphocytes by apoptosis
has exact synonym: programmed cell death of mature B-cells by apoptosis
has exact synonym: programmed cell death of mature B-lymphocytes by apoptosis
has exact synonym: programmed cell death, mature B cells
has exact synonym: programmed cell death, mature B lymphocytes
has exact synonym: programmed cell death, mature B-cells
has exact synonym: programmed cell death, mature B-lymphocytes
has narrow synonym: mature B cell apoptosis
has OBO namespace: biological_process
id: GO:0002901
type: Class
subclass of: B cell apoptotic process
subclass of: Restriction
  on property: part_of
  some values from: B cell homeostasis

regulation of B cell apoptotic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell apoptotic process.
has narrow synonym: regulation of B cell apoptosis
has OBO namespace: biological_process
id: GO:0002902
type: Class
subclass of: GO_0070228
subclass of: Restriction
  on property: RO_0002211
  some values from: B cell apoptotic process

negative regulation of B cell apoptotic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
has exact synonym: down regulation of B cell apoptosis
has exact synonym: down-regulation of B cell apoptosis
has exact synonym: downregulation of B cell apoptosis
has narrow synonym: inhibition of B cell apoptosis
has narrow synonym: negative regulation of B cell apoptosis
has OBO namespace: biological_process
id: GO:0002903
type: Class
subclass of: regulation of B cell apoptotic process
subclass of: GO_0070229
subclass of: Restriction
  on property: RO_0002212
  some values from: B cell apoptotic process

positive regulation of B cell apoptotic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.
has exact synonym: up regulation of B cell apoptosis
has exact synonym: up-regulation of B cell apoptosis
has exact synonym: upregulation of B cell apoptosis
has narrow synonym: activation of B cell apoptosis
has narrow synonym: positive regulation of B cell apoptosis
has narrow synonym: stimulation of B cell apoptosis
has OBO namespace: biological_process
id: GO:0002904
type: Class
subclass of: regulation of B cell apoptotic process
subclass of: GO_0070230
subclass of: Restriction
  on property: RO_0002213
  some values from: B cell apoptotic process

regulation of mature B cell apoptotic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process.
has narrow synonym: regulation of mature B cell apoptosis
has OBO namespace: biological_process
id: GO:0002905
type: Class
subclass of: regulation of immune system process
subclass of: regulation of B cell apoptotic process
subclass of: GO_0032844
subclass of: Restriction
  on property: RO_0002211
  some values from: mature B cell apoptotic process

negative regulation of mature B cell apoptotic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process.
has exact synonym: down regulation of mature B cell apoptosis
has exact synonym: down-regulation of mature B cell apoptosis
has exact synonym: downregulation of mature B cell apoptosis
has narrow synonym: inhibition of mature B cell apoptosis
has narrow synonym: negative regulation of mature B cell apoptosis
has OBO namespace: biological_process
id: GO:0002906
type: Class
subclass of: negative regulation of B cell apoptotic process
subclass of: regulation of mature B cell apoptotic process
subclass of: Restriction
  on property: RO_0002212
  some values from: mature B cell apoptotic process

positive regulation of mature B cell apoptotic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process.
has exact synonym: up regulation of mature B cell apoptosis
has exact synonym: up-regulation of mature B cell apoptosis
has exact synonym: upregulation of mature B cell apoptosis
has narrow synonym: activation of mature B cell apoptosis
has narrow synonym: positive regulation of mature B cell apoptosis
has narrow synonym: stimulation of mature B cell apoptosis
has OBO namespace: biological_process
id: GO:0002907
type: Class
subclass of: positive regulation of B cell apoptotic process
subclass of: regulation of mature B cell apoptotic process
subclass of: Restriction
  on property: RO_0002213
  some values from: mature B cell apoptotic process

regulation of peripheral B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral B cell deletion.
has OBO namespace: biological_process
id: GO:0002908
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of B cell mediated immunity
subclass of: regulation of B cell deletion
subclass of: Restriction
  on property: RO_0002211
  some values from: peripheral B cell deletion

negative regulation of peripheral B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion.
has exact synonym: down regulation of peripheral B cell deletion
has exact synonym: down-regulation of peripheral B cell deletion
has exact synonym: downregulation of peripheral B cell deletion
has narrow synonym: inhibition of peripheral B cell deletion
has OBO namespace: biological_process
id: GO:0002909
type: Class
subclass of: negative regulation of B cell deletion
subclass of: regulation of peripheral B cell deletion
subclass of: Restriction
  on property: RO_0002212
  some values from: peripheral B cell deletion

positive regulation of peripheral B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion.
has exact synonym: up regulation of peripheral B cell deletion
has exact synonym: up-regulation of peripheral B cell deletion
has exact synonym: upregulation of peripheral B cell deletion
has narrow synonym: activation of peripheral B cell deletion
has narrow synonym: stimulation of peripheral B cell deletion
has OBO namespace: biological_process
id: GO:0002910
type: Class
subclass of: positive regulation of B cell deletion
subclass of: regulation of peripheral B cell deletion
subclass of: Restriction
  on property: RO_0002213
  some values from: peripheral B cell deletion

regulation of lymphocyte anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of lymphocyte anergy.
has OBO namespace: biological_process
id: GO:0002911
type: Class
subclass of: regulation of tolerance induction
subclass of: Restriction
  on property: RO_0002211
  some values from: lymphocyte anergy

negative regulation of lymphocyte anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy.
has exact synonym: down regulation of lymphocyte anergy
has exact synonym: down-regulation of lymphocyte anergy
has exact synonym: downregulation of lymphocyte anergy
has narrow synonym: inhibition of lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002912
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002212
  some values from: lymphocyte anergy

positive regulation of lymphocyte anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy.
has exact synonym: up regulation of lymphocyte anergy
has exact synonym: up-regulation of lymphocyte anergy
has exact synonym: upregulation of lymphocyte anergy
has narrow synonym: activation of lymphocyte anergy
has narrow synonym: stimulation of lymphocyte anergy
has OBO namespace: biological_process
id: GO:0002913
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of lymphocyte anergy
subclass of: Restriction
  on property: RO_0002213
  some values from: lymphocyte anergy

regulation of central B cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell anergy.
has OBO namespace: biological_process
id: GO:0002914
type: Class
subclass of: regulation of B cell anergy
subclass of: regulation of central B cell tolerance induction
subclass of: GO_0045577
subclass of: Restriction
  on property: RO_0002211
  some values from: central B cell anergy

negative regulation of central B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy.
has exact synonym: down regulation of central B cell anergy
has exact synonym: down-regulation of central B cell anergy
has exact synonym: downregulation of central B cell anergy
has narrow synonym: inhibition of central B cell anergy
has OBO namespace: biological_process
id: GO:0002915
type: Class
subclass of: negative regulation of B cell anergy
subclass of: regulation of central B cell anergy
subclass of: Restriction
  on property: RO_0002212
  some values from: central B cell anergy

positive regulation of central B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell anergy.
has exact synonym: up regulation of central B cell anergy
has exact synonym: up-regulation of central B cell anergy
has exact synonym: upregulation of central B cell anergy
has narrow synonym: activation of central B cell anergy
has narrow synonym: stimulation of central B cell anergy
has OBO namespace: biological_process
id: GO:0002916
type: Class
subclass of: positive regulation of B cell anergy
subclass of: regulation of central B cell anergy
subclass of: Restriction
  on property: RO_0002213
  some values from: central B cell anergy

regulation of peripheral B cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral B cell anergy.
has OBO namespace: biological_process
id: GO:0002917
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of B cell anergy
subclass of: regulation of B cell mediated immunity
subclass of: Restriction
  on property: RO_0002211
  some values from: peripheral B cell anergy

negative regulation of peripheral B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy.
has exact synonym: down regulation of peripheral B cell anergy
has exact synonym: down-regulation of peripheral B cell anergy
has exact synonym: downregulation of peripheral B cell anergy
has narrow synonym: inhibition of peripheral B cell anergy
has OBO namespace: biological_process
id: GO:0002918
type: Class
subclass of: negative regulation of B cell anergy
subclass of: regulation of peripheral B cell anergy
subclass of: Restriction
  on property: RO_0002212
  some values from: peripheral B cell anergy

positive regulation of peripheral B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy.
has exact synonym: up regulation of peripheral B cell anergy
has exact synonym: up-regulation of peripheral B cell anergy
has exact synonym: upregulation of peripheral B cell anergy
has narrow synonym: activation of peripheral B cell anergy
has narrow synonym: stimulation of peripheral B cell anergy
has OBO namespace: biological_process
id: GO:0002919
type: Class
subclass of: positive regulation of B cell anergy
subclass of: regulation of peripheral B cell anergy
subclass of: Restriction
  on property: RO_0002213
  some values from: peripheral B cell anergy

regulation of humoral immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a humoral immune response.
has OBO namespace: biological_process
id: GO:0002920
type: Class
subclass of: GO_0050776
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0006959

negative regulation of humoral immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.
has exact synonym: down regulation of humoral immune response
has exact synonym: down-regulation of humoral immune response
has exact synonym: downregulation of humoral immune response
has narrow synonym: inhibition of humoral immune response
has OBO namespace: biological_process
id: GO:0002921
type: Class
subclass of: regulation of humoral immune response
subclass of: GO_0050777
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0006959

positive regulation of humoral immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a humoral immune response.
has exact synonym: up regulation of humoral immune response
has exact synonym: up-regulation of humoral immune response
has exact synonym: upregulation of humoral immune response
has narrow synonym: activation of humoral immune response
has narrow synonym: stimulation of humoral immune response
has OBO namespace: biological_process
id: GO:0002922
type: Class
subclass of: regulation of humoral immune response
subclass of: GO_0050778
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0006959

regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has OBO namespace: biological_process
id: GO:0002923
type: Class
subclass of: regulation of immunoglobulin mediated immune response
subclass of: regulation of humoral immune response
subclass of: Restriction
  on property: RO_0002211
  some values from: humoral immune response mediated by circulating immunoglobulin

negative regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has exact synonym: down regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: down-regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: downregulation of humoral immune response mediated by circulating immunoglobulin
has narrow synonym: inhibition of humoral immune response mediated by circulating immunoglobulin
has OBO namespace: biological_process
id: GO:0002924
type: Class
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: negative regulation of humoral immune response
subclass of: regulation of humoral immune response mediated by circulating immunoglobulin
subclass of: Restriction
  on property: RO_0002212
  some values from: humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has exact synonym: up regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: up-regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: upregulation of humoral immune response mediated by circulating immunoglobulin
has narrow synonym: activation of humoral immune response mediated by circulating immunoglobulin
has narrow synonym: stimulation of humoral immune response mediated by circulating immunoglobulin
has OBO namespace: biological_process
id: GO:0002925
type: Class
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: positive regulation of humoral immune response
subclass of: regulation of humoral immune response mediated by circulating immunoglobulin
subclass of: Restriction
  on property: RO_0002213
  some values from: humoral immune response mediated by circulating immunoglobulin

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.
IAO_0000115: The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
has exact synonym: mcm5s2U34 biosynthesis
has OBO namespace: biological_process
id: GO:0002926
type: Class
subclass of: tRNA wobble uridine modification

archaeosine-tRNA biosynthetic process
IAO_0000115: The chemical reactions and pathways involved in the biosynthesis of archaeosine, a an archaea-specific modified base found at position 15 in the in the D-loop of certain archaeal tRNAs.
has OBO namespace: biological_process
id: GO:0002927
type: Class
comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine.
subclass of: GO_0006400

MECO complex
IAO_0000115: A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.
has exact synonym: meta-coactivator complex
has OBO namespace: cellular_component
id: GO:0002929
type: Class
subclass of: GO_0043234

trabecular meshwork development
IAO_0000115: The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.
has OBO namespace: biological_process
id: GO:0002930
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0043010

response to ischemia
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
has OBO namespace: biological_process
id: GO:0002931
type: Class
comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia .
subclass of: GO_0006950

tendon sheath development
IAO_0000115: The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.
has OBO namespace: biological_process
id: GO:0002932
type: Class
subclass of: GO_0061448
subclass of: Restriction
  on property: part_of
  some values from: GO_0035989

lipid hydroxylation
IAO_0000115: The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
has OBO namespace: biological_process
has related synonym: fatty acid hydroxylation
id: GO:0002933
type: Class
subclass of: GO_0030258

desmosome organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
has OBO namespace: biological_process
id: GO:0002934
type: Class
subclass of: GO_0045216

tRNA (adenine-C2-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA.
has OBO namespace: molecular_function
id: GO:0002935
type: Class
subclass of: GO_0008169
subclass of: GO_0016426

bradykinin biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin.
has OBO namespace: biological_process
id: GO:0002936
type: Class
subclass of: GO_0043043

tRNA 4-thiouridine biosynthesis
IAO_0000115: The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs.
has OBO namespace: biological_process
id: GO:0002937
type: Class
comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to he unidentified intermediate. NuvC also participate sin thiamine synthesis.
subclass of: GO_0034227

tRNA guanine ribose methylation
IAO_0000115: The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety.
has OBO namespace: biological_process
id: GO:0002938
type: Class
subclass of: tRNA nucleoside ribose methylation

tRNA N1-guanine methylation
IAO_0000115: The process whereby a guanine in tRNA is methylated at position N1 of the guanine.
has OBO namespace: biological_process
has related synonym: tRNA m1-guanine biosynthesis
id: GO:0002939
type: Class
subclass of: GO_0030488

tRNA N2-guanine methylation
IAO_0000115: The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.
has OBO namespace: biological_process
has related synonym: tRNA m2-guanine biosynthesis
id: GO:0002940
type: Class
subclass of: GO_0030488

synoviocyte proliferation
IAO_0000115: The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues.
has OBO namespace: biological_process
id: GO:0002941
type: Class
subclass of: GO_0008283

tRNA m2,2-guanine biosynthesis
IAO_0000115: The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position.
has OBO namespace: biological_process
id: GO:0002942
type: Class
subclass of: GO_0030488

tRNA dihydrouridine synthesis
IAO_0000115: The process whereby a uridine in a transfer RNA is converted to dihydrouridine.
has OBO namespace: biological_process
id: GO:0002943
type: Class
comment: Dihydrouridine is found in numerous positions within loop I, the so called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b.
subclass of: GO_0006400

cyclin K-CDK12 complex
IAO_0000115: A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
has OBO namespace: cellular_component
has related synonym: CycK/Cdk12 complex
id: GO:0002944
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex

cyclin K-CDK13 complex
IAO_0000115: A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
has OBO namespace: cellular_component
has related synonym: CycK/Cdk13 complex
id: GO:0002945
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex

tRNA C5-cytosine methylation
IAO_0000115: The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine.
has OBO namespace: biological_process
has related synonym: tRNA 5-methylcytosine biosynthesis
id: GO:0002946
type: Class
subclass of: GO_0030488

generation of a signal involved in cell-cell signaling
IAO_0000115: The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
has broad synonym: formation of a signal
has broad synonym: signal generation
has exact synonym: generation of a signal involved in cell-cell signalling
has OBO namespace: biological_process
id: GO:0003001
type: Class
subclass of: GO_0044763
subclass of: Restriction
  on property: part_of
  some values from: GO_0007267

regionalization
IAO_0000115: The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
has OBO namespace: biological_process
has related synonym: pattern formation
id: GO:0003002
type: Class
subclass of: GO_0007389

follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
IAO_0000115: The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis.
has OBO namespace: biological_process
has related synonym: follicular fluid formation in ovarian follicle antrum during fused antrum stage
id: GO:0003003
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: Restriction
  on property: part_of
  some values from: GO_0048165

follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
IAO_0000115: The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis.
has OBO namespace: biological_process
has related synonym: follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage
id: GO:0003004
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: Restriction
  on property: part_of
  some values from: GO_0048164

follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
IAO_0000115: The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis.
has OBO namespace: biological_process
has related synonym: follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage
id: GO:0003005
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: Restriction
  on property: part_of
  some values from: GO_0048163

developmental process involved in reproduction
IAO_0000115: A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
has OBO namespace: biological_process
has related synonym: reproductive developmental process
id: GO:0003006
type: Class
subclass of: GO_0032502
subclass of: GO_0044702
subclass of: Restriction
  on property: part_of
  some values from: reproduction

heart morphogenesis
IAO_0000115: The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
has OBO namespace: biological_process
has related synonym: cardiac morphogenesis
id: GO:0003007
type: Class
subclass of: GO_0009887
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

system process
IAO_0000115: A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
has exact synonym: organ system process
has OBO namespace: biological_process
id: GO:0003008
type: Class
subclass of: GO_0044707

skeletal muscle contraction
IAO_0000115: A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
has OBO namespace: biological_process
id: GO:0003009
type: Class
subclass of: GO_0006941
subclass of: Restriction
  on property: part_of
  some values from: GO_0050881

voluntary skeletal muscle contraction
IAO_0000115: A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.
has OBO namespace: biological_process
id: GO:0003010
type: Class
subclass of: skeletal muscle contraction

involuntary skeletal muscle contraction
IAO_0000115: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control.
has OBO namespace: biological_process
id: GO:0003011
type: Class
subclass of: skeletal muscle contraction

muscle system process
IAO_0000115: A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
has OBO namespace: biological_process
has related synonym: muscle physiological process
id: GO:0003012
type: Class
subclass of: system process

circulatory system process
IAO_0000115: A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
has db xref: Wikipedia:Circulatory_system
has OBO namespace: biological_process
id: GO:0003013
in subset: goslim generic
type: Class
subclass of: system process

renal system process
IAO_0000115: A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism.
has exact synonym: excretory system process
has OBO namespace: biological_process
has related synonym: kidney system process
id: GO:0003014
type: Class
subclass of: system process

heart process
IAO_0000115: A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
has OBO namespace: biological_process
has related synonym: cardiac process
id: GO:0003015
type: Class
subclass of: circulatory system process

respiratory system process
IAO_0000115: A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
has alternative id: GO:0010802
has exact synonym: respiratory gaseous exchange by respiratory system
has OBO namespace: biological_process
id: GO:0003016
type: Class
subclass of: system process
subclass of: GO_0007585

lymph circulation
IAO_0000115: The flow of lymph through the body of an animal.
has OBO namespace: biological_process
id: GO:0003017
type: Class
subclass of: circulatory system process

vascular process in circulatory system
IAO_0000115: A circulatory process that occurs at the level of the vasculature.
has exact synonym: vasculature process
has OBO namespace: biological_process
id: GO:0003018
type: Class
subclass of: circulatory system process

central nervous system control of baroreceptor feedback
IAO_0000115: The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris.
has OBO namespace: biological_process
id: GO:0003019
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

detection of reduced oxygen by chemoreceptor signaling
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of reduced oxygen by chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003020
type: Class
subclass of: GO_0070483
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by chemoreceptor signaling

detection of increased carbon dioxide by chemoreceptor signaling
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of increased carbon dioxide by chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003021
type: Class
subclass of: detection of carbon dioxide
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by chemoreceptor signaling

detection of pH by chemoreceptor signaling
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of pH by chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003022
type: Class
subclass of: detection of hydrogen ion
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by chemoreceptor signaling

baroreceptor detection of increased arterial stretch
IAO_0000115: The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal.
has OBO namespace: biological_process
id: GO:0003023
type: Class
subclass of: baroreceptor detection of arterial stretch
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to increased systemic arterial blood pressure

baroreceptor detection of decreased arterial stretch
IAO_0000115: The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal.
has OBO namespace: biological_process
id: GO:0003024
type: Class
subclass of: baroreceptor detection of arterial stretch
subclass of: Restriction
  on property: part_of
  some values from: baroreceptor response to decreased systemic arterial blood pressure

regulation of systemic arterial blood pressure by baroreceptor feedback
IAO_0000115: The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.
has exact synonym: baroreceptor regulation of systemic arterial blood pressure
has OBO namespace: biological_process
id: GO:0003025
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
IAO_0000115: The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.
has exact synonym: aortic arch baroreceptor control of systemic arterial blood pressure
has OBO namespace: biological_process
id: GO:0003026
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by baroreceptor feedback

regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has broad synonym: vagal reflex
has exact synonym: carotid body chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: carotid body chemoreceptor response to lowering of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003027
type: Class
subclass of: regulation of systemic arterial blood pressure by chemoreceptor signaling

regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: aortic body chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: aortic body chemoreceptor response to lowering of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003028
type: Class
subclass of: regulation of systemic arterial blood pressure by chemoreceptor signaling

detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies.
has exact synonym: detection of hypoxic conditions in blood by carotid body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003029
type: Class
subclass of: detection of hypoxic conditions in blood by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

detection of hydrogen ion
IAO_0000115: The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0003030
type: Class
subclass of: GO_0009593

detection of carbon dioxide
IAO_0000115: The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0003031
type: Class
subclass of: GO_0009593

detection of oxygen
IAO_0000115: The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.
has OBO namespace: biological_process
id: GO:0003032
type: Class
subclass of: GO_0009593
subclass of: GO_0070482

detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies.
has exact synonym: detection of hypoxic conditions in blood by aortic body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003033
type: Class
subclass of: detection of hypoxic conditions in blood by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

detection of increased carbon dioxide by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of increased carbon dioxide by aortic body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003034
type: Class
subclass of: detection of increased carbon dioxide by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

detection of increased carbon dioxide by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of increased carbon dioxide by carotid body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003035
type: Class
subclass of: detection of increased carbon dioxide by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

detection of pH by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of pH by aortic body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003036
type: Class
subclass of: detection of pH by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

detection of pH by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of pH by carotid body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003037
type: Class
subclass of: detection of pH by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

detection of reduced oxygen by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of reduced oxygen by aortic body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003038
type: Class
subclass of: detection of reduced oxygen by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

detection of reduced oxygen by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of reduced oxygen by carotid body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003039
type: Class
subclass of: detection of reduced oxygen by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

excitation of vasomotor center by aortic body chemoreceptor signaling
IAO_0000115: The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by aortic body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003040
type: Class
subclass of: excitation of vasomotor center by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

excitation of vasomotor center by carotid body chemoreceptor signaling
IAO_0000115: The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by carotid body chemoreceptor signalling
has OBO namespace: biological_process
id: GO:0003041
type: Class
subclass of: excitation of vasomotor center by chemoreceptor signaling
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has OBO namespace: biological_process
has related synonym: vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure
id: GO:0003042
type: Class
subclass of: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has OBO namespace: biological_process
has related synonym: vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure
id: GO:0003043
type: Class
subclass of: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

regulation of systemic arterial blood pressure mediated by a chemical signal
IAO_0000115: The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.
has exact synonym: blood pressure regulation mediated by a chemical signal
has OBO namespace: biological_process
id: GO:0003044
type: Class
subclass of: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by physical factors
IAO_0000115: The regulation of blood pressure mediated by detection of forces within the circulatory system.
has exact synonym: blood pressure regulation by physical factors
has OBO namespace: biological_process
id: GO:0003045
type: Class
subclass of: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by stress relaxation
IAO_0000115: The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs.
has exact synonym: blood pressure regulation by stress relaxation
has OBO namespace: biological_process
id: GO:0003046
type: Class
subclass of: regulation of systemic arterial blood pressure by physical factors
subclass of: negative regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by epinephrine
IAO_0000115: The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine.
has exact synonym: regulation of blood pressure by adrenaline
has OBO namespace: biological_process
has related synonym: blood pressure regulation by epinephrine
id: GO:0003047
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by norepinephrine-epinephrine

regulation of systemic arterial blood pressure by norepinephrine
IAO_0000115: The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.
has exact synonym: regulation of blood pressure by noradrenaline
has OBO namespace: biological_process
has related synonym: blood pressure regulation by norepinephrine
id: GO:0003048
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by norepinephrine-epinephrine

regulation of systemic arterial blood pressure by capillary fluid shift
IAO_0000115: The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment.
has exact synonym: blood pressure regulation by capillary fluid shift
has OBO namespace: biological_process
id: GO:0003049
type: Class
subclass of: regulation of systemic arterial blood pressure by physical factors

regulation of systemic arterial blood pressure by atrial natriuretic peptide
IAO_0000115: The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
has exact synonym: blood pressure regulation by atrial natriuretic peptide
has OBO namespace: biological_process
has related synonym: blood pressure regulation by ANP
id: GO:0003050
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

angiotensin-mediated drinking behavior
IAO_0000115: The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.
has exact synonym: angiotensin mediated drinking behavior
has OBO namespace: biological_process
id: GO:0003051
type: Class
subclass of: GO_0042756
subclass of: Restriction
  on property: part_of
  some values from: brain renin-angiotensin system

circadian regulation of systemic arterial blood pressure
IAO_0000115: Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours.
has OBO namespace: biological_process
id: GO:0003052
type: Class
subclass of: regulation of systemic arterial blood pressure
subclass of: GO_0007623

circadian regulation of heart rate
IAO_0000115: Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours.
has OBO namespace: biological_process
has related synonym: circadian regulation of heart contraction rate
id: GO:0003053
type: Class
subclass of: regulation of heart rate
subclass of: GO_0007623

circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
IAO_0000115: The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours.
has exact synonym: SCN regulation of blood pressure
has exact synonym: master pacemaker clock regulation of blood pressure
has OBO namespace: biological_process
id: GO:0003054
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: circadian regulation of systemic arterial blood pressure

circadian regulation of heart rate by the suprachiasmatic nucleus
IAO_0000115: The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours.
has exact synonym: SCN regulation of heart rate
has exact synonym: master pacemaker clock regulation of heart rate
has OBO namespace: biological_process
has related synonym: circadian regulation of heart contraction rate by the suprachiasmatic nucleus
id: GO:0003055
type: Class
subclass of: circadian regulation of heart rate

regulation of vascular smooth muscle contraction
IAO_0000115: Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.
has OBO namespace: biological_process
id: GO:0003056
type: Class
subclass of: GO_0006940
subclass of: GO_0019229
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0014829

regulation of the force of heart contraction by chemical signal
IAO_0000115: The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: chemical cardiac inotropy
has OBO namespace: biological_process
has related synonym: regulation of the force of heart muscle contraction by chemical signal
id: GO:0003057
type: Class
subclass of: regulation of the force of heart contraction

hormonal regulation of the force of heart contraction
IAO_0000115: The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: hormonal cardiac inotropy
has OBO namespace: biological_process
has related synonym: hormonal regulation of the force of heart muscle contraction
id: GO:0003058
type: Class
subclass of: regulation of the force of heart contraction by chemical signal

positive regulation of the force of heart contraction by epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction.
has exact synonym: adrenaline cardiac inotropy
has exact synonym: adrenaline regulation of the strength of heart muscle contraction
has exact synonym: epinephrine cardiac inotropy
has exact synonym: increased force of heart contraction by epinephrine
has OBO namespace: biological_process
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by epinephrine
id: GO:0003059
type: Class
subclass of: positive regulation of the force of heart contraction by chemical signal
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of the force of heart contraction by epinephrine-norepinephrine

negative regulation of the force of heart contraction by acetylcholine
IAO_0000115: The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction.
has exact synonym: decreased force of heart contraction by acetylcholine
has OBO namespace: biological_process
id: GO:0003060
type: Class
subclass of: negative regulation of the force of heart contraction by chemical signal
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by acetylcholine

positive regulation of the force of heart contraction by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction.
has exact synonym: increased force of heart contraction by norepinephrine
has exact synonym: noradrenaline cardiac inotropy
has exact synonym: noradrenaline regulation of the strength of heart muscle contraction
has exact synonym: norepinephrine cardiac inotropy
has OBO namespace: biological_process
has related synonym: increased force of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by norepinephrine
id: GO:0003061
type: Class
subclass of: positive regulation of the force of heart contraction by chemical signal
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate by chemical signal
IAO_0000115: The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: chemical cardiac chronotropy
has exact synonym: chemical signal regulation of heart rate
has OBO namespace: biological_process
has related synonym: chemical signal regulation of heart contraction rate
id: GO:0003062
type: Class
subclass of: regulation of heart rate

negative regulation of heart rate by acetylcholine
IAO_0000115: The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction.
has OBO namespace: biological_process
has related synonym: negative regulation of heart contraction rate by acetylcholine
id: GO:0003063
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: GO_0010459
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by acetylcholine

regulation of heart rate by hormone
IAO_0000115: The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: hormonal cardiac chronotropy
has exact synonym: regulation of the rate of heart contraction by hormone
has OBO namespace: biological_process
id: GO:0003064
type: Class
subclass of: regulation of heart rate by chemical signal

positive regulation of heart rate by epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: adrenaline cardiac chronotropy
has exact synonym: adrenaline regulation of the rate of heart muscle contraction
has exact synonym: epinephrine cardiac chronotropy
has OBO namespace: biological_process
has related synonym: positive regulation of heart contraction rate by epinephrine
has related synonym: positive regulation of heart rate by adrenaline
id: GO:0003065
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: GO_0010460
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of heart rate by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: noradrenaline cardiac chronotropy
has exact synonym: noradrenaline regulation of the rate of heart muscle contraction
has exact synonym: norepinephrine cardiac chronotropy
has exact synonym: positive regulation of heart rate by adrenaline
has OBO namespace: biological_process
has related synonym: positive regulation of heart contraction rate by norepinephrine
id: GO:0003066
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: GO_0010460
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of heart rate by epinephrine-norepinephrine

circadian regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has OBO namespace: biological_process
id: GO:0003067
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
subclass of: Restriction
  on property: part_of
  some values from: circadian regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by acetylcholine
IAO_0000115: The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter.
has exact synonym: blood pressure regulation by acetylcholine
has OBO namespace: biological_process
id: GO:0003068
type: Class
subclass of: regulation of systemic arterial blood pressure by neurotransmitter

vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
IAO_0000115: The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.
has OBO namespace: biological_process
id: GO:0003069
type: Class
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure by acetylcholine

regulation of systemic arterial blood pressure by neurotransmitter
IAO_0000115: The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
has OBO namespace: biological_process
id: GO:0003070
type: Class
subclass of: neurological system process involved in regulation of systemic arterial blood pressure
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal

renal system process involved in regulation of systemic arterial blood pressure
IAO_0000115: Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
has exact synonym: renal control of blood pressure
has exact synonym: renal regulation of systemic arterial blood pressure
has OBO namespace: biological_process
id: GO:0003071
type: Class
subclass of: renal system process
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure

renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
IAO_0000115: The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature.
has exact synonym: regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence
has exact synonym: renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence
has OBO namespace: biological_process
id: GO:0003072
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure
IAO_0000115: The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
has OBO namespace: biological_process
id: GO:0003073
type: Class
subclass of: GO_0008217

regulation of diuresis
IAO_0000115: OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.
consider: GO:0035809
has OBO namespace: biological_process
id: GO:0003074
type: Class
comment: This term was made obsolete because its definition was inaccurate.
deprecated: true

renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
IAO_0000115: The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system.
has exact synonym: renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system
has OBO namespace: biological_process
id: GO:0003075
type: Class
subclass of: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

negative regulation of diuresis
IAO_0000115: OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion.
consider: GO:0035811
has OBO namespace: biological_process
id: GO:0003077
type: Class
comment: This term was made obsolete because its definition was inaccurate.
deprecated: true

regulation of natriuresis
IAO_0000115: OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.
consider: GO:0035813
has OBO namespace: biological_process
id: GO:0003078
type: Class
comment: This term was made obsolete because its definition was inaccurate.
deprecated: true

positive regulation of natriuresis
IAO_0000115: OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis.
consider: GO:0035815
has OBO namespace: biological_process
id: GO:0003079
type: Class
comment: This term was made obsolete because its definition was inaccurate.
deprecated: true

negative regulation of natriuresis
IAO_0000115: OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.
consider: GO:0035814
has OBO namespace: biological_process
id: GO:0003080
type: Class
comment: This term was made obsolete because its definition was inaccurate.
deprecated: true

regulation of systemic arterial blood pressure by renin-angiotensin
IAO_0000115: The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
has exact synonym: blood pressure regulation by renin-angiotensin
has OBO namespace: biological_process
id: GO:0003081
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

positive regulation of renal output by angiotensin
IAO_0000115: OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney.
has exact synonym: angiotensin mediated positive regulation of renal output
has exact synonym: angiotensin-mediated positive regulation of renal output
has OBO namespace: biological_process
id: GO:0003082
type: Class
comment: This term was made obsolete because the term is misleading.
deprecated: true

negative regulation of renal output by angiotensin
IAO_0000115: The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney.
has exact synonym: angiotensin mediated negative regulation of renal output
has exact synonym: angiotensin-mediated negative regulation of renal output
has OBO namespace: biological_process
id: GO:0003083
type: Class
subclass of: regulation of renal output by angiotensin
subclass of: positive regulation of systemic arterial blood pressure

positive regulation of systemic arterial blood pressure
IAO_0000115: The process that increases the force with which blood travels through the systemic arterial circulatory system.
has OBO namespace: biological_process
id: GO:0003084
type: Class
subclass of: GO_0045777
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure

negative regulation of systemic arterial blood pressure
IAO_0000115: The process that reduces the force with which blood travels through the systemic arterial circulatory system.
has OBO namespace: biological_process
id: GO:0003085
type: Class
subclass of: GO_0045776
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by local renal renin-angiotensin
IAO_0000115: The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen.
has OBO namespace: biological_process
id: GO:0003086
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin

positive regulation of the force of heart contraction by neuronal epinephrine
IAO_0000115: The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by epinephrine released from the nerve endings
has exact synonym: increased force of heart contraction by neuronal epinephrine
has OBO namespace: biological_process
has related synonym: increased force of heart contraction by neuronal adrenaline
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by neuronal epinephrine
id: GO:0003087
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine

positive regulation of the force of heart contraction by circulating epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by epinephrine in the bloodstream
has OBO namespace: biological_process
has related synonym: increased force of heart contraction by circulating adrenaline
has related synonym: positive regulation of heart contraction by circulating adrenaline
has related synonym: positive regulation of heart contraction by circulating epinephrine
id: GO:0003088
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine
subclass of: Restriction
  on property: part_of
  some values from: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine

positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream.
has exact synonym: increased force of heart contraction by circulating adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by circulating epinephrine-norepinephrine
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine in the blood stream
has OBO namespace: biological_process
has related synonym: positive regulation of heart contraction by circulating adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by circulating epinephrine-norepinephrine
id: GO:0003089
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings.
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings
has exact synonym: increased force of heart contraction by neuronal adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by neuronal epinephrine-norepinephrine
has OBO namespace: biological_process
has related synonym: positive regulation of heart contraction by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by epinephrine-norepinephrine
id: GO:0003090
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine-norepinephrine

renal water homeostasis
IAO_0000115: Renal process involved in the maintenance of an internal steady state of water in the body.
has exact synonym: water homeostasis by the kidney
has OBO namespace: biological_process
id: GO:0003091
type: Class
subclass of: renal system process
subclass of: GO_0050891

renal water retention
IAO_0000115: The process in which renal water excretion is decreased.
has exact synonym: negative regulation of renal water excretion
has OBO namespace: biological_process
id: GO:0003092
type: Class
subclass of: GO_0035811

regulation of glomerular filtration
IAO_0000115: Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.
has OBO namespace: biological_process
id: GO:0003093
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: GO_0044057
subclass of: Restriction
  on property: RO_0002211
  some values from: glomerular filtration

glomerular filtration
IAO_0000115: The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
has OBO namespace: biological_process
id: GO:0003094
type: Class
subclass of: GO_0097205

pressure natriuresis
IAO_0000115: The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis).
has OBO namespace: biological_process
id: GO:0003095
type: Class
subclass of: renal system process involved in regulation of blood volume

renal sodium ion transport
IAO_0000115: The directed movement of sodium ions (Na+) by the kidney.
has OBO namespace: biological_process
id: GO:0003096
type: Class
subclass of: renal system process
subclass of: GO_0006814

renal water transport
IAO_0000115: The directed movement of water (H2O) by the kidney.
has OBO namespace: biological_process
id: GO:0003097
type: Class
subclass of: renal system process
subclass of: GO_0006833
subclass of: Restriction
  on property: part_of
  some values from: renal water homeostasis

tubuloglomerular feedback
IAO_0000115: The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.
has db xref: Wikipedia:Tubuloglomerular_feedback
has OBO namespace: biological_process
id: GO:0003098
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: Restriction
  on property: part_of
  some values from: regulation of glomerular filtration

positive regulation of the force of heart contraction by chemical signal
IAO_0000115: Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: positive regulation of the force of heart muscle contraction by chemical signal
has OBO namespace: biological_process
id: GO:0003099
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
subclass of: GO_0045823

regulation of systemic arterial blood pressure by endothelin
IAO_0000115: The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.
has OBO namespace: biological_process
id: GO:0003100
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
IAO_0000115: The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system.
has OBO namespace: biological_process
has related synonym: regulation of blood pressure by circulating adrenaline-noradrenaline
id: GO:0003101
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

positive regulation of diuresis by angiotensin
IAO_0000115: OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis.
consider: GO:0035810
has exact synonym: angiotensin-mediated positive regulation of diuresis
has OBO namespace: biological_process
id: GO:0003102
type: Class
comment: This term was made obsolete because the term is misleading.
deprecated: true

positive regulation of diuresis
IAO_0000115: OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion.
consider: GO:0035810
has OBO namespace: biological_process
id: GO:0003103
type: Class
comment: This term was made obsolete because its definition was inaccurate.
deprecated: true

positive regulation of glomerular filtration
IAO_0000115: Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
has OBO namespace: biological_process
id: GO:0003104
type: Class
subclass of: regulation of glomerular filtration
subclass of: GO_0051240
subclass of: Restriction
  on property: RO_0002213
  some values from: glomerular filtration

negative regulation of glomerular filtration
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
has OBO namespace: biological_process
id: GO:0003105
type: Class
subclass of: regulation of glomerular filtration
subclass of: GO_0051241
subclass of: Restriction
  on property: RO_0002212
  some values from: glomerular filtration

negative regulation of glomerular filtration by angiotensin
IAO_0000115: The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
has broad synonym: angiotensin-mediated regulation of glomerular filtration
has broad synonym: regulation of glomerular filtration by angiotensin
has OBO namespace: biological_process
id: GO:0003106
type: Class
subclass of: negative regulation of renal output by angiotensin
subclass of: Restriction
  on property: part_of
  some values from: negative regulation of glomerular filtration

positive regulation of natriuresis by angiotensin
IAO_0000115: OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion.
has exact synonym: angiotensin-mediated positive regulation of natriuresis
has OBO namespace: biological_process
id: GO:0003107
type: Class
comment: This term was made obsolete because the term is misleading.
deprecated: true

negative regulation of the force of heart contraction by chemical signal
IAO_0000115: Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has OBO namespace: biological_process
has related synonym: negative regulation of the force of heart muscle contraction by chemical signal
id: GO:0003108
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
subclass of: GO_0045822

positive regulation of the force of heart contraction by circulating norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by circulating norepinephrine
has OBO namespace: biological_process
has related synonym: increased force of heart contraction by circulating noradrenaline
id: GO:0003109
type: Class
subclass of: positive regulation of the force of heart contraction by norepinephrine

positive regulation of the force of heart contraction by neuronal norepinephrine
IAO_0000115: The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by neuronal norepinephrine
has OBO namespace: biological_process
has related synonym: increased force of heart contraction by neuronal noradrenaline
id: GO:0003110
type: Class
subclass of: positive regulation of the force of heart contraction by norepinephrine

positive regulation of heart rate by circulating epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by circulating adrenaline
has OBO namespace: biological_process
id: GO:0003111
type: Class
subclass of: positive regulation of heart rate by epinephrine

positive regulation of heart rate by neuronal epinephrine
IAO_0000115: The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by neuronal adrenaline
has OBO namespace: biological_process
id: GO:0003112
type: Class
subclass of: positive regulation of heart rate by epinephrine

positive regulation of heart rate by neuronal norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by neuronal noradrenaline
has OBO namespace: biological_process
id: GO:0003113
type: Class
subclass of: positive regulation of heart rate by norepinephrine

positive regulation of heart rate by circulating norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by circulating noradrenaline
has OBO namespace: biological_process
id: GO:0003114
type: Class
subclass of: positive regulation of heart rate by norepinephrine

regulation of vasoconstriction by epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings.
has OBO namespace: biological_process
id: GO:0003115
type: Class
subclass of: GO_0019229

regulation of vasoconstriction by norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings.
has OBO namespace: biological_process
id: GO:0003116
type: Class
subclass of: GO_0019229

regulation of vasoconstriction by circulating norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.
has exact synonym: regulation of vasoconstriction by circulating noradrenaline
has OBO namespace: biological_process
id: GO:0003117
type: Class
subclass of: regulation of vasoconstriction by norepinephrine

regulation of vasoconstriction by neuronal norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings.
has exact synonym: regulation of vasoconstriction by neuronal noradrenaline
has OBO namespace: biological_process
id: GO:0003118
type: Class
subclass of: regulation of vasoconstriction by norepinephrine

regulation of vasoconstriction by neuronal epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings.
has exact synonym: regulation of vasoconstriction by neuronal adrenaline
has OBO namespace: biological_process
id: GO:0003119
type: Class
subclass of: regulation of vasoconstriction by epinephrine

regulation of vasoconstriction by circulating epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.
has exact synonym: regulation of vasoconstriction by circulating adrenaline
has OBO namespace: biological_process
id: GO:0003120
type: Class
subclass of: regulation of vasoconstriction by epinephrine

regulation of vasodilation by epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings.
has exact synonym: regulation of vasodilation by adrenaline
has OBO namespace: biological_process
id: GO:0003121
type: Class
subclass of: GO_0042312

regulation of vasodilation by norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings.
has exact synonym: regulation of vasodilation by noradrenaline
has OBO namespace: biological_process
id: GO:0003122
type: Class
subclass of: GO_0042312

regulation of vasodilation by circulating epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.
has exact synonym: regulation of vasodilation by circulating adrenaline
has OBO namespace: biological_process
id: GO:0003123
type: Class
subclass of: regulation of vasodilation by epinephrine

regulation of vasodilation by neuronal epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings.
has exact synonym: regulation of vasodilation by neuronal adrenaline
has OBO namespace: biological_process
id: GO:0003124
type: Class
subclass of: regulation of vasodilation by epinephrine

regulation of vasodilation by circulating norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.
has exact synonym: regulation of vasodilation by circulating noradrenaline
has OBO namespace: biological_process
id: GO:0003125
type: Class
subclass of: regulation of vasodilation by norepinephrine

regulation of vasodilation by neuronal norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings.
has exact synonym: regulation of vasodilation by neuronal noradrenaline
has OBO namespace: biological_process
id: GO:0003126
type: Class
subclass of: regulation of vasodilation by norepinephrine

detection of nodal flow
IAO_0000115: The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.
has OBO namespace: biological_process
id: GO:0003127
type: Class
subclass of: GO_0009726
subclass of: Restriction
  on property: part_of
  some values from: GO_0007368

heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.
has OBO namespace: biological_process
id: GO:0003128
type: Class
subclass of: GO_0010092
subclass of: Restriction
  on property: part_of
  some values from: GO_0060914

heart induction
IAO_0000115: The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.
has OBO namespace: biological_process
id: GO:0003129
type: Class
subclass of: organ induction
subclass of: GO_2000826
subclass of: Restriction
  on property: RO_0002213
  some values from: heart field specification

BMP signaling pathway involved in heart induction
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.
has exact synonym: BMP signalling pathway involved in heart induction
has OBO namespace: biological_process
id: GO:0003130
type: Class
subclass of: GO_0060850
subclass of: GO_0061312
subclass of: Restriction
  on property: part_of
  some values from: heart induction
subclass of: Restriction
  on property: part_of
  some values from: endodermal-mesodermal cell signaling involved in heart induction

mesodermal-endodermal cell signaling
IAO_0000115: Any process that mediates the transfer of information from mesodermal cells to endodermal cells.
has exact synonym: mesodermal-endodermal cell signalling
has OBO namespace: biological_process
id: GO:0003131
type: Class
subclass of: GO_0007267

mesodermal-endodermal cell signaling involved in heart induction
IAO_0000115: Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction.
has exact synonym: mesodermal-endodermal cell signalling involved in heart induction
has OBO namespace: biological_process
id: GO:0003132
type: Class
subclass of: mesodermal-endodermal cell signaling
subclass of: GO_0045168
subclass of: Restriction
  on property: part_of
  some values from: heart induction

endodermal-mesodermal cell signaling
IAO_0000115: Any process that mediates the transfer of information from endodermal cells to mesodermal cells.
has exact synonym: endodermal-mesodermal cell signalling
has OBO namespace: biological_process
id: GO:0003133
type: Class
subclass of: GO_0007267

endodermal-mesodermal cell signaling involved in heart induction
IAO_0000115: Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction.
has exact synonym: endodermal-mesodermal cell signalling involved in heart induction
has OBO namespace: biological_process
id: GO:0003134
type: Class
subclass of: endodermal-mesodermal cell signaling
subclass of: GO_0045168
subclass of: Restriction
  on property: part_of
  some values from: heart induction

fibroblast growth factor receptor signaling pathway involved in heart induction
IAO_0000115: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction.
has exact synonym: fibroblast growth factor receptor signalling pathway involved in heart induction
has OBO namespace: biological_process
id: GO:0003135
type: Class
subclass of: GO_0061313
subclass of: Restriction
  on property: part_of
  some values from: heart induction

negative regulation of heart induction by canonical Wnt receptor signaling pathway
IAO_0000115: Any canonical Wnt receptor signaling that decreases the rate, frequency or extent of heart induction.
has exact synonym: negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt receptor signalling pathway
has OBO namespace: biological_process
id: GO:0003136
type: Class
subclass of: GO_0009997
subclass of: GO_0061316
subclass of: GO_1901320
subclass of: Restriction
  on property: RO_0002212
  some values from: heart induction

Notch signaling pathway involved in heart induction
IAO_0000115: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.
has exact synonym: Notch signalling pathway involved in heart induction
has OBO namespace: biological_process
id: GO:0003137
type: Class
subclass of: GO_0061314
subclass of: Restriction
  on property: part_of
  some values from: heart induction

primary heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
has exact synonym: FHS specification
has exact synonym: first heart field specification
has OBO namespace: biological_process
id: GO:0003138
type: Class
subclass of: heart field specification

secondary heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
has exact synonym: SHF specification
has exact synonym: second heart field specification
has narrow synonym: anterior heart field specification
has OBO namespace: biological_process
id: GO:0003139
type: Class
subclass of: heart field specification

determination of left/right asymmetry in lateral mesoderm
IAO_0000115: The establishment of the lateral mesoderm with respect to the left and right halves.
has OBO namespace: biological_process
id: GO:0003140
type: Class
subclass of: GO_0007368
subclass of: Restriction
  on property: part_of
  some values from: GO_0048368

transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
IAO_0000115: OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination.
IAO_0100001: GO:1900164
has exact synonym: TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
has exact synonym: TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry
has exact synonym: TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
has exact synonym: TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry
has exact synonym: transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination
has exact synonym: transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry
has OBO namespace: biological_process
id: GO:0003141
type: Class
comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
deprecated: true

cardiogenic plate morphogenesis
IAO_0000115: The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.
has exact synonym: cardiac crescent morphogenesis
has OBO namespace: biological_process
id: GO:0003142
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

embryonic heart tube morphogenesis
IAO_0000115: The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
has OBO namespace: biological_process
id: GO:0003143
type: Class
subclass of: GO_0048598
subclass of: GO_0048646
subclass of: GO_0060562
subclass of: Restriction
  on property: part_of
  some values from: GO_0035050
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

embryonic heart tube formation
IAO_0000115: The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
has OBO namespace: biological_process
id: GO:0003144
type: Class
subclass of: embryonic epithelial tube formation
subclass of: Restriction
  on property: part_of
  some values from: embryonic heart tube morphogenesis

embryonic heart tube formation via epithelial folding
IAO_0000115: The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.
has OBO namespace: biological_process
id: GO:0003145
type: Class
subclass of: embryonic heart tube formation

heart jogging
IAO_0000115: The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.
has exact synonym: cardiac jogging
has OBO namespace: biological_process
id: GO:0003146
type: Class
subclass of: GO_0035239
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: embryonic heart tube morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: GO_0061371

neural crest cell migration involved in heart formation
IAO_0000115: The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.
has OBO namespace: biological_process
id: GO:0003147
type: Class
subclass of: neural crest cell migration
subclass of: GO_0060974
subclass of: Restriction
  on property: part_of
  some values from: GO_0061308
subclass of: Restriction
  on property: part_of
  some values from: GO_0060914

outflow tract septum morphogenesis
IAO_0000115: The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
has OBO namespace: biological_process
id: GO:0003148
type: Class
subclass of: GO_0060411
subclass of: Restriction
  on property: part_of
  some values from: outflow tract morphogenesis

membranous septum morphogenesis
IAO_0000115: The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
has OBO namespace: biological_process
id: GO:0003149
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0060412

muscular septum morphogenesis
IAO_0000115: The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
has OBO namespace: biological_process
id: GO:0003150
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0060412

outflow tract morphogenesis
IAO_0000115: The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
has OBO namespace: biological_process
id: GO:0003151
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

morphogenesis of an epithelial fold involved in embryonic heart tube formation
IAO_0000115: The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.
has OBO namespace: biological_process
id: GO:0003152
type: Class
subclass of: GO_0048598
subclass of: GO_0048646
subclass of: GO_0060571
subclass of: Restriction
  on property: part_of
  some values from: embryonic heart tube formation
subclass of: Restriction
  on property: part_of
  some values from: embryonic heart tube formation via epithelial folding

closure of embryonic heart tube
IAO_0000115: Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.
has OBO namespace: biological_process
id: GO:0003153
type: Class
subclass of: GO_0060606
subclass of: Restriction
  on property: part_of
  some values from: embryonic heart tube formation via epithelial folding

BMP signaling pathway involved in determination of left/right symmetry
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
has exact synonym: BMP signaling pathway involved in determination of left/right asymmetry
has exact synonym: BMP signalling pathway involved in determination of left/right symmetry
has OBO namespace: biological_process
id: GO:0003154
type: Class
subclass of: GO_0030509
subclass of: GO_1900094
subclass of: Restriction
  on property: part_of
  some values from: GO_0007368

BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
IAO_0000115: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry.
has exact synonym: BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination
has exact synonym: BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry
has OBO namespace: biological_process
id: GO:0003155
type: Class
subclass of: BMP signaling pathway involved in determination of left/right symmetry
subclass of: Restriction
  on property: part_of
  some values from: determination of left/right asymmetry in lateral mesoderm

regulation of organ formation
IAO_0000115: Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
has OBO namespace: biological_process
id: GO:0003156
type: Class
subclass of: GO_2000027
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0048645

endocardium development
IAO_0000115: The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
has OBO namespace: biological_process
id: GO:0003157
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

endothelium development
IAO_0000115: The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities,and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
has OBO namespace: biological_process
id: GO:0003158
type: Class
subclass of: GO_0009888

morphogenesis of an endothelium
IAO_0000115: The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
has OBO namespace: biological_process
id: GO:0003159
type: Class
subclass of: morphogenesis of an epithelium
subclass of: Restriction
  on property: part_of
  some values from: endothelium development

endocardium morphogenesis
IAO_0000115: The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
has OBO namespace: biological_process
id: GO:0003160
type: Class
subclass of: GO_0009653
subclass of: Restriction
  on property: part_of
  some values from: endocardium development

cardiac conduction system development
IAO_0000115: The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
has exact synonym: cardiac impulse conducting system development
has exact synonym: heart conduction system development
has OBO namespace: biological_process
id: GO:0003161
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

atrioventricular node development
IAO_0000115: The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.
has exact synonym: AV node development
has OBO namespace: biological_process
id: GO:0003162
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: cardiac conduction system development

sinoatrial node development
IAO_0000115: The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.
has exact synonym: SA node development
has exact synonym: SAN development
has narrow synonym: sinus node development
has OBO namespace: biological_process
id: GO:0003163
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: cardiac conduction system development

His-Purkinje system development
IAO_0000115: The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.
has OBO namespace: biological_process
id: GO:0003164
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: cardiac conduction system development

Purkinje myocyte development
IAO_0000115: The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.
has exact synonym: cardiac Purkinje fiber development
has OBO namespace: biological_process
id: GO:0003165
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: His-Purkinje system development

bundle of His development
IAO_0000115: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.
has exact synonym: atrioventricular bundle development
has OBO namespace: biological_process
id: GO:0003166
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: His-Purkinje system development

atrioventricular bundle cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.
has exact synonym: AV bundle cell differentiation
has OBO namespace: biological_process
id: GO:0003167
type: Class
subclass of: GO_0060932
subclass of: Restriction
  on property: part_of
  some values from: bundle of His development

Purkinje myocyte differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.
has exact synonym: cardiac Purkinje fiber cell differentiation
has OBO namespace: biological_process
id: GO:0003168
type: Class
subclass of: GO_0060932
subclass of: Restriction
  on property: part_of
  some values from: Purkinje myocyte development

coronary vein morphogenesis
IAO_0000115: The process in which the anatomical structures of veins of the heart are generated and organized.
has OBO namespace: biological_process
id: GO:0003169
type: Class
subclass of: GO_0048845
subclass of: GO_0060977

heart valve development
IAO_0000115: The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.
has exact synonym: cardiac valve development
has OBO namespace: biological_process
id: GO:0003170
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

atrioventricular valve development
IAO_0000115: The progression of the atrioventricular valve over time, from its formation to the mature structure.
has exact synonym: AV valve development
has OBO namespace: biological_process
id: GO:0003171
type: Class
subclass of: heart valve development

sinoatrial valve development
IAO_0000115: The progression of the sinoatrial valve over time, from its formation to the mature structure.
has exact synonym: SA valve development
has OBO namespace: biological_process
id: GO:0003172
type: Class
subclass of: heart valve development

ventriculo bulbo valve development
IAO_0000115: The progression of the ventriculo bulbo valve over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003173
type: Class
subclass of: heart valve development

mitral valve development
IAO_0000115: The progression of the mitral valve over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003174
type: Class
subclass of: heart valve development

tricuspid valve development
IAO_0000115: The progression of the tricuspid valve over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003175
type: Class
subclass of: heart valve development

aortic valve development
IAO_0000115: The progression of the aortic valve over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003176
type: Class
subclass of: heart valve development

pulmonary valve development
IAO_0000115: The progression of the pulmonary valve over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003177
type: Class
subclass of: heart valve development

coronary sinus valve development
IAO_0000115: The progression of the valve of the coronary sinus over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003178
type: Class
subclass of: heart valve development

heart valve morphogenesis
IAO_0000115: The process in which the structure of a heart valve is generated and organized.
has narrow synonym: heart valve remodeling
has narrow synonym: heart valve remodelling
has OBO namespace: biological_process
id: GO:0003179
type: Class
subclass of: GO_0009653
subclass of: Restriction
  on property: part_of
  some values from: heart valve development

aortic valve morphogenesis
IAO_0000115: The process in which the structure of the aortic valve is generated and organized.
has OBO namespace: biological_process
id: GO:0003180
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: aortic valve development

atrioventricular valve morphogenesis
IAO_0000115: The process in which the structure of the atrioventricular valve is generated and organized.
has exact synonym: AV valve morphogenesis
has OBO namespace: biological_process
id: GO:0003181
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: atrioventricular valve development

coronary sinus valve morphogenesis
IAO_0000115: The process in which the structure of the coronary sinus valve is generated and organized.
has OBO namespace: biological_process
id: GO:0003182
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: coronary sinus valve development

mitral valve morphogenesis
IAO_0000115: The process in which the structure of the mitral valve is generated and organized.
has OBO namespace: biological_process
id: GO:0003183
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: mitral valve development

pulmonary valve morphogenesis
IAO_0000115: The process in which the structure of the pulmonary valve is generated and organized.
has OBO namespace: biological_process
id: GO:0003184
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: pulmonary valve development

sinoatrial valve morphogenesis
IAO_0000115: The process in which the structure of the sinoatrial valve is generated and organized.
has exact synonym: SA valve morphogenesis
has OBO namespace: biological_process
id: GO:0003185
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: sinoatrial valve development

tricuspid valve morphogenesis
IAO_0000115: The process in which the structure of the tricuspid valve is generated and organized.
has OBO namespace: biological_process
id: GO:0003186
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: tricuspid valve development

ventriculo bulbo valve morphogenesis
IAO_0000115: The process in which the structure of the ventriculo bulbo valve is generated and organized.
has OBO namespace: biological_process
id: GO:0003187
type: Class
subclass of: heart valve morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: ventriculo bulbo valve development

heart valve formation
IAO_0000115: The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003188
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: heart valve morphogenesis

aortic valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003189
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: aortic valve morphogenesis

atrioventricular valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has exact synonym: AV valve formation
has OBO namespace: biological_process
id: GO:0003190
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: atrioventricular valve morphogenesis

coronary sinus valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003191
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: coronary sinus valve morphogenesis

mitral valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003192
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: mitral valve morphogenesis

pulmonary valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003193
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: pulmonary valve morphogenesis

sinoatrial valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has exact synonym: SA valve formation
has OBO namespace: biological_process
id: GO:0003194
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: sinoatrial valve morphogenesis

tricuspid valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003195
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: tricuspid valve morphogenesis

ventriculo bulbo valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has OBO namespace: biological_process
id: GO:0003196
type: Class
subclass of: heart valve formation
subclass of: Restriction
  on property: part_of
  some values from: ventriculo bulbo valve morphogenesis

endocardial cushion development
IAO_0000115: The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has OBO namespace: biological_process
id: GO:0003197
type: Class
subclass of: GO_0060485
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

epithelial to mesenchymal transition involved in endocardial cushion formation
IAO_0000115: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.
has OBO namespace: biological_process
id: GO:0003198
type: Class
subclass of: GO_0060317
subclass of: Restriction
  on property: part_of
  some values from: endocardial cushion formation

endocardial cushion to mesenchymal transition involved in heart valve formation
IAO_0000115: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
has exact synonym: endocardial cushion to mesenchymal transition involved in valve formation
has OBO namespace: biological_process
id: GO:0003199
type: Class
subclass of: GO_0090500
subclass of: Restriction
  on property: part_of
  some values from: heart valve formation

endocardial cushion to mesenchymal transition involved in heart chamber septation
IAO_0000115: A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum.
has OBO namespace: biological_process
id: GO:0003200
type: Class
subclass of: GO_0090500
subclass of: Restriction
  on property: part_of
  some values from: GO_0060411

epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
IAO_0000115: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature.
has OBO namespace: biological_process
id: GO:0003201
type: Class
subclass of: GO_0060317
subclass of: Restriction
  on property: part_of
  some values from: GO_0060977

endocardial cushion to mesenchymal transition involved in cardiac skeleton development
IAO_0000115: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton.
has OBO namespace: biological_process
id: GO:0003202
type: Class
subclass of: GO_0090500
subclass of: Restriction
  on property: part_of
  some values from: cardiac skeleton development

endocardial cushion morphogenesis
IAO_0000115: The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has OBO namespace: biological_process
id: GO:0003203
type: Class
subclass of: GO_0072132
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: endocardial cushion development

cardiac skeleton development
IAO_0000115: The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.
has exact synonym: heart fibrous skeleton development
has OBO namespace: biological_process
id: GO:0003204
type: Class
subclass of: GO_0061448
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

cardiac chamber development
IAO_0000115: The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
has OBO namespace: biological_process
id: GO:0003205
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

cardiac chamber morphogenesis
IAO_0000115: The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
has exact synonym: heart chamber morphogenesis
has OBO namespace: biological_process
id: GO:0003206
type: Class
subclass of: GO_0009653
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cardiac chamber development

cardiac chamber formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
has exact synonym: heart chamber formation
has OBO namespace: biological_process
id: GO:0003207
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: cardiac chamber morphogenesis

cardiac ventricle morphogenesis
IAO_0000115: The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
has OBO namespace: biological_process
id: GO:0003208
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cardiac ventricle development

cardiac atrium morphogenesis
IAO_0000115: The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
has OBO namespace: biological_process
id: GO:0003209
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cardiac atrium development

cardiac atrium formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
has OBO namespace: biological_process
id: GO:0003210
type: Class
subclass of: cardiac chamber formation
subclass of: Restriction
  on property: part_of
  some values from: cardiac atrium morphogenesis

cardiac ventricle formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
has OBO namespace: biological_process
id: GO:0003211
type: Class
subclass of: cardiac chamber formation
subclass of: Restriction
  on property: part_of
  some values from: cardiac ventricle morphogenesis

cardiac left atrium morphogenesis
IAO_0000115: The process in which the left cardiac atrium is generated and organized.
has OBO namespace: biological_process
id: GO:0003212
type: Class
subclass of: cardiac atrium morphogenesis

cardiac right atrium morphogenesis
IAO_0000115: The process in which the right cardiac atrium is generated and organized.
has OBO namespace: biological_process
id: GO:0003213
type: Class
subclass of: cardiac atrium morphogenesis

cardiac left ventricle morphogenesis
IAO_0000115: The process in which the left cardiac ventricle is generated and organized.
has OBO namespace: biological_process
id: GO:0003214
type: Class
subclass of: cardiac ventricle morphogenesis

cardiac right ventricle morphogenesis
IAO_0000115: The process in which the right cardiac ventricle is generated and organized.
has OBO namespace: biological_process
id: GO:0003215
type: Class
subclass of: cardiac ventricle morphogenesis

cardiac left atrium formation
IAO_0000115: The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.
has OBO namespace: biological_process
id: GO:0003216
type: Class
subclass of: cardiac atrium formation
subclass of: Restriction
  on property: part_of
  some values from: cardiac left atrium morphogenesis

cardiac right atrium formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.
has OBO namespace: biological_process
id: GO:0003217
type: Class
subclass of: cardiac atrium formation
subclass of: Restriction
  on property: part_of
  some values from: cardiac right atrium morphogenesis

cardiac left ventricle formation
IAO_0000115: The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.
has OBO namespace: biological_process
id: GO:0003218
type: Class
subclass of: cardiac ventricle formation
subclass of: Restriction
  on property: part_of
  some values from: cardiac left ventricle morphogenesis

cardiac right ventricle formation
IAO_0000115: The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.
has OBO namespace: biological_process
id: GO:0003219
type: Class
subclass of: cardiac ventricle formation
subclass of: Restriction
  on property: part_of
  some values from: cardiac right ventricle morphogenesis

left ventricular cardiac muscle tissue morphogenesis
IAO_0000115: The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.
has exact synonym: left ventricular myocardium morphogenesis
has OBO namespace: biological_process
id: GO:0003220
type: Class
subclass of: GO_0055010
subclass of: Restriction
  on property: part_of
  some values from: cardiac left ventricle morphogenesis

right ventricular cardiac muscle tissue morphogenesis
IAO_0000115: The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.
has exact synonym: right ventricle myocardium morphogenesis
has OBO namespace: biological_process
id: GO:0003221
type: Class
subclass of: GO_0055010
subclass of: Restriction
  on property: part_of
  some values from: cardiac right ventricle morphogenesis

ventricular trabecula myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
has OBO namespace: biological_process
has related synonym: trabecula carnea morphogenesis
id: GO:0003222
type: Class
subclass of: GO_0055010
subclass of: GO_0061384

ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.
has OBO namespace: biological_process
id: GO:0003223
type: Class
subclass of: GO_0055010

left ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized.
has OBO namespace: biological_process
id: GO:0003224
type: Class
subclass of: left ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular compact myocardium morphogenesis

left ventricular trabecular myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.
has OBO namespace: biological_process
id: GO:0003225
type: Class
subclass of: left ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular trabecula myocardium morphogenesis

right ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized.
has OBO namespace: biological_process
id: GO:0003226
type: Class
subclass of: right ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular compact myocardium morphogenesis

right ventricular trabecular myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the right ventricular myocardium are generated and organized.
has OBO namespace: biological_process
id: GO:0003227
type: Class
subclass of: right ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular trabecula myocardium morphogenesis

atrial cardiac muscle tissue development
IAO_0000115: The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.
has exact synonym: atrial myocardium development
has OBO namespace: biological_process
id: GO:0003228
type: Class
subclass of: GO_0048738

ventricular cardiac muscle tissue development
IAO_0000115: The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
has exact synonym: ventricular myocardium development
has OBO namespace: biological_process
id: GO:0003229
type: Class
subclass of: GO_0048738

cardiac atrium development
IAO_0000115: The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
has OBO namespace: biological_process
id: GO:0003230
type: Class
subclass of: cardiac chamber development

cardiac ventricle development
IAO_0000115: The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
has OBO namespace: biological_process
id: GO:0003231
type: Class
subclass of: cardiac chamber development

bulbus arteriosus development
IAO_0000115: The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber.
has OBO namespace: biological_process
id: GO:0003232
type: Class
subclass of: cardiac chamber development

bulbus arteriosus morphogenesis
IAO_0000115: The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber.
has OBO namespace: biological_process
id: GO:0003233
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: bulbus arteriosus development

bulbus arteriosus formation
IAO_0000115: The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart.
has OBO namespace: biological_process
id: GO:0003234
type: Class
subclass of: cardiac chamber formation
subclass of: Restriction
  on property: part_of
  some values from: bulbus arteriosus morphogenesis

sinus venosus development
IAO_0000115: The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
has OBO namespace: biological_process
id: GO:0003235
type: Class
subclass of: cardiac chamber development

sinus venosus morphogenesis
IAO_0000115: The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
has OBO namespace: biological_process
id: GO:0003236
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: sinus venosus development

sinus venosus formation
IAO_0000115: The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
has OBO namespace: biological_process
id: GO:0003237
type: Class
subclass of: cardiac chamber formation
subclass of: Restriction
  on property: part_of
  some values from: sinus venosus morphogenesis

conus arteriosus development
IAO_0000115: The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
has OBO namespace: biological_process
id: GO:0003238
type: Class
subclass of: cardiac chamber development

conus arteriosus morphogenesis
IAO_0000115: The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
has OBO namespace: biological_process
id: GO:0003239
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: conus arteriosus development

conus arteriosus formation
IAO_0000115: The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
has OBO namespace: biological_process
id: GO:0003240
type: Class
subclass of: cardiac chamber formation
subclass of: Restriction
  on property: part_of
  some values from: conus arteriosus morphogenesis

growth involved in heart morphogenesis
IAO_0000115: Developmental growth that contributes to the shaping of the heart.
has OBO namespace: biological_process
id: GO:0003241
type: Class
subclass of: GO_0060560
subclass of: Restriction
  on property: part_of
  some values from: GO_0060419
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

cardiac chamber ballooning
IAO_0000115: The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping.
has OBO namespace: biological_process
id: GO:0003242
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cardiac chamber morphogenesis

circumferential growth involved in left ventricle morphogenesis
IAO_0000115: The morphogenetic growth in which the left ventricle grows expanding its external boundary.
has OBO namespace: biological_process
id: GO:0003243
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cardiac left ventricle morphogenesis

radial growth involved in right ventricle morphogenesis
IAO_0000115: The morphogenic growth in which the right ventricle grows along a radial axis.
has OBO namespace: biological_process
id: GO:0003244
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cardiac right ventricle morphogenesis

cardiac muscle tissue growth involved in heart morphogenesis
IAO_0000115: The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.
has OBO namespace: biological_process
id: GO:0003245
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: GO_0055017
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: GO_0055008

embryonic cardiac muscle cell growth involved in heart morphogenesis
IAO_0000115: The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart.
has exact synonym: embryonic cardiac muscle physiological hypertrophy
has OBO namespace: biological_process
id: GO:0003246
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: GO_0061049
subclass of: Restriction
  on property: part_of
  some values from: cardiac muscle tissue growth involved in heart morphogenesis

post-embryonic cardiac muscle cell growth involved in heart morphogenesis
IAO_0000115: The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.
has OBO namespace: biological_process
id: GO:0003247
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: GO_0048588
subclass of: Restriction
  on property: part_of
  some values from: cardiac muscle tissue growth involved in heart morphogenesis

heart capillary growth
IAO_0000115: The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.
has OBO namespace: biological_process
id: GO:0003248
type: Class
subclass of: GO_0048589
subclass of: Restriction
  on property: part_of
  some values from: GO_0060419
subclass of: Restriction
  on property: part_of
  some values from: GO_0060976

cell proliferation involved in heart valve morphogenesis
IAO_0000115: The multiplication or reproduction of cells that contributes to the shaping of a heart valve.
has OBO namespace: biological_process
id: GO:0003249
type: Class
subclass of: GO_0061323
subclass of: GO_2000793
subclass of: Restriction
  on property: part_of
  some values from: heart valve morphogenesis

regulation of cell proliferation involved in heart valve morphogenesis
IAO_0000115: Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
has OBO namespace: biological_process
id: GO:0003250
type: Class
subclass of: GO_2000136
subclass of: Restriction
  on property: RO_0002211
  some values from: cell proliferation involved in heart valve morphogenesis

positive regulation of cell proliferation involved in heart valve morphogenesis
IAO_0000115: Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
has OBO namespace: biological_process
id: GO:0003251
type: Class
subclass of: regulation of cell proliferation involved in heart valve morphogenesis
subclass of: GO_2000138
subclass of: Restriction
  on property: RO_0002213
  some values from: cell proliferation involved in heart valve morphogenesis

negative regulation of cell proliferation involved in heart valve morphogenesis
IAO_0000115: Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
has OBO namespace: biological_process
id: GO:0003252
type: Class
subclass of: regulation of cell proliferation involved in heart valve morphogenesis
subclass of: GO_2000137
subclass of: Restriction
  on property: RO_0002212
  some values from: cell proliferation involved in heart valve morphogenesis

cardiac neural crest cell migration involved in outflow tract morphogenesis
IAO_0000115: The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.
has OBO namespace: biological_process
id: GO:0003253
type: Class
subclass of: neural crest cell migration
subclass of: GO_0060973
subclass of: Restriction
  on property: part_of
  some values from: GO_0061309
subclass of: Restriction
  on property: part_of
  some values from: outflow tract morphogenesis

regulation of membrane depolarization
IAO_0000115: Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
has OBO namespace: biological_process
id: GO:0003254
type: Class
subclass of: GO_0050794
subclass of: GO_2000021
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0051899

endocardial precursor cell differentiation
IAO_0000115: The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate.
has OBO namespace: biological_process
id: GO:0003255
type: Class
subclass of: GO_0010002

regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
IAO_0000115: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.
has OBO namespace: biological_process
id: GO:0003256
type: Class
subclass of: GO_1901213
subclass of: Restriction
  on property: part_of
  some values from: GO_0060379

positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
IAO_0000115: Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.
has OBO namespace: biological_process
id: GO:0003257
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
subclass of: GO_1901228
subclass of: Restriction
  on property: part_of
  some values from: GO_0060379

regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
IAO_0000115: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell.
has OBO namespace: biological_process
id: GO:0003258
type: Class
subclass of: GO_1901213
subclass of: Restriction
  on property: part_of
  some values from: endocardial precursor cell differentiation

cardioblast anterior-lateral migration
IAO_0000115: The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has OBO namespace: biological_process
id: GO:0003259
type: Class
subclass of: cardioblast migration

cardioblast migration
IAO_0000115: The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has OBO namespace: biological_process
id: GO:0003260
type: Class
subclass of: GO_0060974
subclass of: Restriction
  on property: part_of
  some values from: GO_0060914

cardiac muscle progenitor cell migration to the midline involved in heart field formation
IAO_0000115: The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart.
has exact synonym: myocardial progenitor cell midline convergence
has OBO namespace: biological_process
id: GO:0003261
type: Class
subclass of: GO_0060975

endocardial progenitor cell migration to the midline involved in heart field formation
IAO_0000115: The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.
has OBO namespace: biological_process
id: GO:0003262
type: Class
subclass of: GO_0060975

cardioblast proliferation
IAO_0000115: The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has OBO namespace: biological_process
id: GO:0003263
type: Class
subclass of: GO_0061323
subclass of: Restriction
  on property: part_of
  some values from: GO_0060914

regulation of cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has OBO namespace: biological_process
id: GO:0003264
type: Class
subclass of: regulation of organ formation
subclass of: GO_2000136
subclass of: Restriction
  on property: RO_0002211
  some values from: cardioblast proliferation

regulation of primary heart field cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle.
has exact synonym: regulation of FHF cardioblast proliferation
has exact synonym: regulation of first heart field cardioblast proliferation
has OBO namespace: biological_process
has related synonym: regulation of first heart field cardiac proliferation
id: GO:0003265
type: Class
subclass of: regulation of cardioblast proliferation

regulation of secondary heart field cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).
has exact synonym: regulation of SHF cardioblast proliferation
has exact synonym: regulation of second heart field cardioblast proliferation
has OBO namespace: biological_process
id: GO:0003266
type: Class
subclass of: regulation of cardioblast proliferation

canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation
has exact synonym: canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation
has OBO namespace: biological_process
id: GO:0003267
type: Class
subclass of: GO_0044340
subclass of: GO_0061316
subclass of: Restriction
  on property: part_of
  some values from: GO_0072513

fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation
has exact synonym: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation
has exact synonym: fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation
has OBO namespace: biological_process
id: GO:0003268
type: Class
subclass of: GO_0061313
subclass of: Restriction
  on property: part_of
  some values from: regulation of secondary heart field cardioblast proliferation

BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: BMP signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation
has OBO namespace: biological_process
id: GO:0003269
type: Class
subclass of: GO_0061312
subclass of: Restriction
  on property: part_of
  some values from: regulation of secondary heart field cardioblast proliferation

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation
has OBO namespace: biological_process
has related synonym: Notch signaling pathway involved in regulation of second heart field cardioblast proliferation
id: GO:0003270
type: Class
subclass of: GO_0061314
subclass of: Restriction
  on property: part_of
  some values from: regulation of secondary heart field cardioblast proliferation

smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: hh signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
has exact synonym: smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation
has OBO namespace: biological_process
id: GO:0003271
type: Class
subclass of: GO_0007224
subclass of: GO_0061311
subclass of: Restriction
  on property: part_of
  some values from: regulation of secondary heart field cardioblast proliferation

endocardial cushion formation
IAO_0000115: The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has OBO namespace: biological_process
id: GO:0003272
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: endocardial cushion morphogenesis

cell migration involved in endocardial cushion formation
IAO_0000115: The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has OBO namespace: biological_process
id: GO:0003273
type: Class
subclass of: GO_0060973
subclass of: Restriction
  on property: part_of
  some values from: endocardial cushion formation

endocardial cushion fusion
IAO_0000115: The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.
has OBO namespace: biological_process
id: GO:0003274
type: Class
subclass of: GO_0016337
subclass of: GO_0061343
subclass of: Restriction
  on property: part_of
  some values from: endocardial cushion morphogenesis

apoptotic process involved in outflow tract morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.
has narrow synonym: apoptosis involved in outflow tract morphogenesis
has OBO namespace: biological_process
id: GO:0003275
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: outflow tract morphogenesis

apoptotic process involved in heart valve morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of a heart valve.
has narrow synonym: apoptosis involved in heart valve morphogenesis
has OBO namespace: biological_process
id: GO:0003276
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: heart valve morphogenesis

apoptotic process involved in endocardial cushion morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has narrow synonym: apoptosis involved in endocardial cushion morphogenesis
has OBO namespace: biological_process
id: GO:0003277
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: endocardial cushion morphogenesis

apoptotic process involved in heart morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of the heart.
has narrow synonym: apoptosis involved in heart morphogenesis
has OBO namespace: biological_process
id: GO:0003278
type: Class
subclass of: GO_0060561
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

cardiac septum development
IAO_0000115: The progression of a cardiac septum over time, from its initial formation to the mature structure.
has exact synonym: heart septum development
has OBO namespace: biological_process
id: GO:0003279
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: cardiac chamber development

ventricular septum development
IAO_0000115: The progression of the ventricular septum over time from its formation to the mature structure.
has exact synonym: interventricular septum development
has narrow synonym: septum inferius development
has OBO namespace: biological_process
id: GO:0003281
type: Class
subclass of: cardiac septum development
subclass of: Restriction
  on property: part_of
  some values from: cardiac ventricle development

ventricular septum intermedium development
IAO_0000115: The progression of the ventricular septum intermedium over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003282
type: Class
subclass of: ventricular septum development

atrial septum development
IAO_0000115: The progression of the atrial septum over time, from its initial formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003283
type: Class
subclass of: cardiac septum development
subclass of: Restriction
  on property: part_of
  some values from: cardiac atrium development

septum primum development
IAO_0000115: The progression of the septum primum over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003284
type: Class
subclass of: atrial septum development

septum secundum development
IAO_0000115: The progression of the septum secundum over time, from its initial formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003285
type: Class
subclass of: atrial septum development

atrial septum intermedium development
IAO_0000115: The progression of the atrial septum intermedium over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003286
type: Class
subclass of: atrial septum development

ventricular septum intermedium morphogenesis
IAO_0000115: The developmental process in which a ventricular septum intermedium is generated and organized.
has OBO namespace: biological_process
id: GO:0003288
type: Class
subclass of: GO_0060412

atrial septum primum morphogenesis
IAO_0000115: The process in which anatomical structure of an atrial septum primum is generated and organized.
has OBO namespace: biological_process
id: GO:0003289
type: Class
subclass of: GO_0060413
subclass of: Restriction
  on property: part_of
  some values from: septum primum development

atrial septum secundum morphogenesis
IAO_0000115: The process in which anatomical structure of an atrial septum secundum is generated and organized.
has OBO namespace: biological_process
id: GO:0003290
type: Class
subclass of: GO_0060413
subclass of: Restriction
  on property: part_of
  some values from: septum secundum development

atrial septum intermedium morphogenesis
IAO_0000115: The process in which anatomical structure of an atrial septum intermedium is generated and organized.
has OBO namespace: biological_process
id: GO:0003291
type: Class
subclass of: GO_0060413
subclass of: Restriction
  on property: part_of
  some values from: atrial septum intermedium development

cardiac septum cell differentiation
IAO_0000115: The process in which an endocardial cushion cell becomes a cell of a cardiac septum.
has OBO namespace: biological_process
id: GO:0003292
type: Class
subclass of: GO_0035051
subclass of: Restriction
  on property: part_of
  some values from: cardiac septum development

heart valve cell differentiation
IAO_0000115: The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.
has OBO namespace: biological_process
id: GO:0003293
type: Class
subclass of: GO_0035051
subclass of: Restriction
  on property: part_of
  some values from: heart valve development

atrial ventricular junction remodeling
IAO_0000115: The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.
has exact synonym: atrioventricular junction remodeling
has OBO namespace: biological_process
has related synonym: atrio-ventricular junction remodeling
id: GO:0003294
type: Class
subclass of: GO_0048771
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

cell proliferation involved in atrial ventricular junction remodeling
IAO_0000115: The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
has exact synonym: cell proliferation involved in atrio-ventricular junction remodeling
has exact synonym: cell proliferation involved in atrioventricular junction remodeling
has OBO namespace: biological_process
id: GO:0003295
type: Class
subclass of: GO_0061323
subclass of: Restriction
  on property: part_of
  some values from: atrial ventricular junction remodeling

apoptotic process involved in atrial ventricular junction remodeling
IAO_0000115: Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
has exact synonym: apoptosis involved in atrio-ventricular junction remodeling
has exact synonym: apoptosis involved in atrioventricular junction remodeling
has narrow synonym: apoptosis involved in atrial ventricular junction remodeling
has OBO namespace: biological_process
id: GO:0003296
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: atrial ventricular junction remodeling

heart wedging
IAO_0000115: The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart.
has OBO namespace: biological_process
id: GO:0003297
type: Class
subclass of: GO_0035239
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: heart morphogenesis

physiological muscle hypertrophy
IAO_0000115: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.
has OBO namespace: biological_process
id: GO:0003298
type: Class
subclass of: GO_0014896

muscle hypertrophy in response to stress
IAO_0000115: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.
has OBO namespace: biological_process
id: GO:0003299
type: Class
subclass of: GO_0006950
subclass of: GO_0014896
subclass of: GO_0043500

cardiac muscle hypertrophy
IAO_0000115: The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
has OBO namespace: biological_process
id: GO:0003300
type: Class
subclass of: GO_0014897

physiological cardiac muscle hypertrophy
IAO_0000115: The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.
has OBO namespace: biological_process
id: GO:0003301
type: Class
subclass of: physiological muscle hypertrophy
subclass of: cardiac muscle hypertrophy
subclass of: Restriction
  on property: part_of
  some values from: GO_0055017

transforming growth factor beta receptor signaling pathway involved in heart jogging
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.
has exact synonym: transforming growth factor beta receptor signalling pathway involved in heart jogging
has OBO namespace: biological_process
id: GO:0003302
type: Class
subclass of: GO_0035463
subclass of: GO_0061311
subclass of: Restriction
  on property: part_of
  some values from: heart jogging

BMP signaling pathway involved in heart jogging
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.
has exact synonym: BMP signalling pathway involved in heart jogging
has OBO namespace: biological_process
id: GO:0003303
type: Class
subclass of: BMP signaling pathway involved in determination of left/right symmetry
subclass of: GO_0061312
subclass of: Restriction
  on property: part_of
  some values from: heart jogging

myocardial epithelial involution involved in heart jogging
IAO_0000115: The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging.
has OBO namespace: biological_process
id: GO:0003304
type: Class
subclass of: GO_0048646
subclass of: GO_0060571
subclass of: Restriction
  on property: part_of
  some values from: heart jogging

cell migration involved in heart jogging
IAO_0000115: The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging.
has OBO namespace: biological_process
id: GO:0003305
type: Class
subclass of: GO_0060973
subclass of: Restriction
  on property: part_of
  some values from: heart jogging

Wnt receptor signaling pathway involved in heart development
IAO_0000115: The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: Wnt receptor signalling pathway involved in heart development
has OBO namespace: biological_process
id: GO:0003306
type: Class
subclass of: GO_0016055
subclass of: GO_0061311
subclass of: Restriction
  on property: part_of
  some values from: GO_0007507

regulation of Wnt receptor signaling pathway involved in heart development
IAO_0000115: Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: regulation of Wnt receptor signalling pathway involved in heart development
has OBO namespace: biological_process
id: GO:0003307
type: Class
subclass of: GO_0030111
subclass of: GO_2000026
subclass of: Restriction
  on property: RO_0002211
  some values from: Wnt receptor signaling pathway involved in heart development

negative regulation of Wnt receptor signaling pathway involved in heart development
IAO_0000115: Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: negative regulation of Wnt receptor signalling pathway involved in heart development
has OBO namespace: biological_process
id: GO:0003308
type: Class
subclass of: regulation of Wnt receptor signaling pathway involved in heart development
subclass of: GO_0030178
subclass of: Restriction
  on property: RO_0002212
  some values from: Wnt receptor signaling pathway involved in heart development

type B pancreatic cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell differentiation
has exact synonym: pancreatic beta cell differentiation
has OBO namespace: biological_process
id: GO:0003309
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0031018

pancreatic A cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has exact synonym: pancreatic alpha cell differentiation
has OBO namespace: biological_process
id: GO:0003310
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0031018

pancreatic D cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
has exact synonym: pancreatic delta cell differentiation
has OBO namespace: biological_process
id: GO:0003311
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0031018

pancreatic PP cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
has exact synonym: pancreatic polypeptide-producing cell differentiation
has OBO namespace: biological_process
id: GO:0003312
type: Class
subclass of: GO_0030154
subclass of: Restriction
  on property: part_of
  some values from: GO_0031018

heart rudiment development
IAO_0000115: The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
has exact synonym: heart cone development
has OBO namespace: biological_process
id: GO:0003313
type: Class
subclass of: GO_0060429
subclass of: Restriction
  on property: part_of
  some values from: GO_0035050

heart rudiment morphogenesis
IAO_0000115: The process in which the anatomical structures of the heart rudiment are generated and organized.
has exact synonym: heart cone morphogenesis
has OBO namespace: biological_process
id: GO:0003314
type: Class
subclass of: morphogenesis of an epithelium
subclass of: GO_0048598
subclass of: Restriction
  on property: part_of
  some values from: heart rudiment development

heart rudiment formation
IAO_0000115: The developmental process pertaining to the initial formation of the heart rudiment.
has exact synonym: heart cone formation
has OBO namespace: biological_process
id: GO:0003315
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: heart rudiment morphogenesis

establishment of myocardial progenitor cell apical/basal polarity
IAO_0000115: The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment.
has exact synonym: myocardial progenitor epithelial polarization
has OBO namespace: biological_process
id: GO:0003316
type: Class
subclass of: GO_0045198
subclass of: Restriction
  on property: part_of
  some values from: heart rudiment formation

cardioblast cell midline fusion
IAO_0000115: The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment.
has exact synonym: cardiac progenitor cell midline fusion
has OBO namespace: biological_process
id: GO:0003317
type: Class
subclass of: GO_0016337
subclass of: Restriction
  on property: part_of
  some values from: heart rudiment formation

cell migration to the midline involved in heart development
IAO_0000115: The orderly movement of a cell toward the midline that contributes to the progression of the heart over time.
has OBO namespace: biological_process
id: GO:0003318
type: Class
subclass of: GO_0060973

cardioblast migration to the midline involved in heart rudiment formation
IAO_0000115: The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.
has OBO namespace: biological_process
id: GO:0003319
type: Class
subclass of: cell migration to the midline involved in heart development
subclass of: Restriction
  on property: part_of
  some values from: heart rudiment formation

heart rudiment involution
IAO_0000115: The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube.
has OBO namespace: biological_process
id: GO:0003320
type: Class
subclass of: morphogenesis of an epithelial fold involved in embryonic heart tube formation

positive regulation of blood pressure by epinephrine-norepinephrine
IAO_0000115: Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine.
has OBO namespace: biological_process
id: GO:0003321
type: Class
subclass of: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
subclass of: GO_0045777

pancreatic A cell development
IAO_0000115: The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has exact synonym: pancreatic alpha cell development
has OBO namespace: biological_process
id: GO:0003322
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: pancreatic A cell differentiation

type B pancreatic cell development
IAO_0000115: The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell development
has exact synonym: pancreatic beta cell development
has OBO namespace: biological_process
id: GO:0003323
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: type B pancreatic cell differentiation

pancreatic D cell development
IAO_0000115: The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.
has exact synonym: pancreatic delta cell development
has OBO namespace: biological_process
id: GO:0003324
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: pancreatic D cell differentiation

pancreatic PP cell development
IAO_0000115: The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
has OBO namespace: biological_process
id: GO:0003325
type: Class
subclass of: GO_0048468
subclass of: Restriction
  on property: part_of
  some values from: pancreatic PP cell differentiation

pancreatic A cell fate commitment
IAO_0000115: The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has OBO namespace: biological_process
id: GO:0003326
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: pancreatic A cell differentiation

type B pancreatic cell fate commitment
IAO_0000115: The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell fate commitment
has OBO namespace: biological_process
id: GO:0003327
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: type B pancreatic cell differentiation

pancreatic D cell fate commitment
IAO_0000115: The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin.
has OBO namespace: biological_process
id: GO:0003328
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: pancreatic D cell differentiation

pancreatic PP cell fate commitment
IAO_0000115: The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
has OBO namespace: biological_process
id: GO:0003329
type: Class
subclass of: GO_0045165
subclass of: Restriction
  on property: part_of
  some values from: pancreatic PP cell differentiation

regulation of extracellular matrix constituent secretion
IAO_0000115: Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
has OBO namespace: biological_process
id: GO:0003330
type: Class
subclass of: GO_0051046
subclass of: GO_0051128
subclass of: GO_0060341
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0070278

positive regulation of extracellular matrix constituent secretion
IAO_0000115: Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
has OBO namespace: biological_process
id: GO:0003331
type: Class
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_0048522
subclass of: GO_0051047
subclass of: Restriction
  on property: RO_0002213
  some values from: GO_0070278

negative regulation of extracellular matrix constituent secretion
IAO_0000115: Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
has OBO namespace: biological_process
id: GO:0003332
type: Class
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_0048523
subclass of: GO_0051048
subclass of: Restriction
  on property: RO_0002212
  some values from: GO_0070278

amino acid transmembrane transport
IAO_0000115: The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore.
has OBO namespace: biological_process
id: GO:0003333
type: Class
subclass of: GO_0006865
subclass of: GO_0034220

keratinocyte development
IAO_0000115: The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.
has OBO namespace: biological_process
id: GO:0003334
type: Class
subclass of: epithelial cell development
subclass of: Restriction
  on property: part_of
  some values from: GO_0030216

corneocyte development
IAO_0000115: The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.
has OBO namespace: biological_process
id: GO:0003335
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: Restriction
  on property: part_of
  some values from: keratinocyte development

corneocyte desquamation
IAO_0000115: The delamination process that results in the shedding of a corneocyte from the surface of the epidermis.
has exact synonym: epidermal desquamation
has OBO namespace: biological_process
id: GO:0003336
type: Class
subclass of: GO_0060232
subclass of: Restriction
  on property: part_of
  some values from: corneocyte development

mesenchymal to epithelial transition involved in metanephros morphogenesis
IAO_0000115: A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
has OBO namespace: biological_process
has related synonym: metanephric mesenchyme to epithelial transition
id: GO:0003337
type: Class
subclass of: GO_0048646
subclass of: GO_0060231
subclass of: Restriction
  on property: part_of
  some values from: metanephros morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: GO_0072283

metanephros morphogenesis
IAO_0000115: The process in which the anatomical structures of the metanephros are generated and organized.
has OBO namespace: biological_process
id: GO:0003338
type: Class
subclass of: GO_0060993
subclass of: Restriction
  on property: part_of
  some values from: metanephros development

regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
IAO_0000115: Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
has OBO namespace: biological_process
id: GO:0003339
type: Class
subclass of: GO_0010769
subclass of: GO_0030856
subclass of: GO_0072215
subclass of: GO_2000027
subclass of: Restriction
  on property: RO_0002211
  some values from: mesenchymal to epithelial transition involved in metanephros morphogenesis

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
IAO_0000115: Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
has OBO namespace: biological_process
id: GO:0003340
type: Class
subclass of: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
subclass of: GO_0010771
subclass of: Restriction
  on property: RO_0002212
  some values from: mesenchymal to epithelial transition involved in metanephros morphogenesis

cilium movement
IAO_0000115: The directed, self-propelled movement of a cilium.
has OBO namespace: biological_process
has related synonym: ciliary motility
has related synonym: cilium beating
id: GO:0003341
type: Class
subclass of: GO_0007018

proepicardium development
IAO_0000115: The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.
has OBO namespace: biological_process
id: GO:0003342
type: Class
subclass of: GO_0060485
subclass of: Restriction
  on property: part_of
  some values from: septum transversum development

septum transversum development
IAO_0000115: The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.
has OBO namespace: biological_process
id: GO:0003343
type: Class
subclass of: GO_0060485

pericardium morphogenesis
IAO_0000115: The process in which the anatomical structure of the pericardium is generated and organized.
has OBO namespace: biological_process
id: GO:0003344
type: Class
subclass of: morphogenesis of an epithelial sheet
subclass of: GO_0048598
subclass of: Restriction
  on property: part_of
  some values from: GO_0060039

proepicardium cell migration involved in pericardium morphogenesis
IAO_0000115: The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart.
has OBO namespace: biological_process
id: GO:0003345
type: Class
subclass of: GO_0060973
subclass of: Restriction
  on property: part_of
  some values from: pericardium morphogenesis

epicardium-derived cell migration to the myocardium
IAO_0000115: The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium.
has OBO namespace: biological_process
id: GO:0003346
type: Class
subclass of: GO_0060973

epicardial cell to mesenchymal cell transition
IAO_0000115: A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.
has OBO namespace: biological_process
id: GO:0003347
type: Class
subclass of: epithelial to mesenchymal transition

cardiac endothelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.
has OBO namespace: biological_process
id: GO:0003348
type: Class
subclass of: GO_0035051

epicardium-derived cardiac endothelial cell differentiation
IAO_0000115: The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.
has OBO namespace: biological_process
id: GO:0003349
type: Class
subclass of: cardiac endothelial cell differentiation

pulmonary myocardium development
IAO_0000115: The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.
has OBO namespace: biological_process
id: GO:0003350
type: Class
subclass of: GO_0014706
subclass of: Restriction
  on property: part_of
  some values from: GO_0060841

epithelial cilium movement
IAO_0000115: The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid.
has OBO namespace: biological_process
has related synonym: epithelial cilium beating
id: GO:0003351
type: Class
subclass of: cilium movement

regulation of cilium movement
IAO_0000115: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has OBO namespace: biological_process
id: GO:0003352
type: Class
subclass of: GO_0060632
subclass of: Restriction
  on property: RO_0002211
  some values from: cilium movement

positive regulation of cilium movement
IAO_0000115: Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has OBO namespace: biological_process
id: GO:0003353
type: Class
subclass of: regulation of cilium movement
subclass of: GO_0051272
subclass of: Restriction
  on property: RO_0002213
  some values from: cilium movement

negative regulation of cilium movement
IAO_0000115: Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has OBO namespace: biological_process
id: GO:0003354
type: Class
subclass of: regulation of cilium movement
subclass of: GO_0051271
subclass of: Restriction
  on property: RO_0002212
  some values from: cilium movement

cilium movement involved in otolith formation
IAO_0000115: The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles.
has OBO namespace: biological_process
id: GO:0003355
type: Class
subclass of: epithelial cilium movement
subclass of: Restriction
  on property: part_of
  some values from: GO_0032475

regulation of cilium beat frequency
IAO_0000115: Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.
has OBO namespace: biological_process
id: GO:0003356
type: Class
subclass of: regulation of cilium movement

noradrenergic neuron differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.
has exact synonym: norepinephrine secreting neuron differentiation
has OBO namespace: biological_process
id: GO:0003357
type: Class
subclass of: GO_0030182

noradrenergic neuron development
IAO_0000115: The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has exact synonym: norepinephrine secreting neuron development
has OBO namespace: biological_process
id: GO:0003358
type: Class
subclass of: GO_0048666
subclass of: Restriction
  on property: part_of
  some values from: noradrenergic neuron differentiation

noradrenergic neuron fate commitment
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron.
has exact synonym: norepinephrine secreting neuron fate commitment
has OBO namespace: biological_process
id: GO:0003359
type: Class
subclass of: GO_0048663
subclass of: Restriction
  on property: part_of
  some values from: noradrenergic neuron differentiation

brainstem development
IAO_0000115: The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.
has OBO namespace: biological_process
id: GO:0003360
type: Class
subclass of: GO_0048856

noradrenergic neuron differentiation involved in brainstem development
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem.
has OBO namespace: biological_process
id: GO:0003361
type: Class
subclass of: noradrenergic neuron differentiation
subclass of: Restriction
  on property: part_of
  some values from: brainstem development

noradrenergic neuron fate commitment involved in brainstem development
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem.
has OBO namespace: biological_process
id: GO:0003362
type: Class
subclass of: noradrenergic neuron fate commitment
subclass of: Restriction
  on property: part_of
  some values from: brainstem development
subclass of: Restriction
  on property: part_of
  some values from: noradrenergic neuron differentiation involved in brainstem development

lamellipodium assembly involved in ameboidal cell migration
IAO_0000115: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.
has OBO namespace: biological_process
id: GO:0003363
type: Class
subclass of: GO_0030032
subclass of: Restriction
  on property: part_of
  some values from: ameboidal cell migration

lamellipodium assembly involved in mesendodermal cell migration
IAO_0000115: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell.
has OBO namespace: biological_process
id: GO:0003364
type: Class
subclass of: lamellipodium assembly involved in ameboidal cell migration
subclass of: GO_0010927
subclass of: Restriction
  on property: part_of
  some values from: GO_0090134

establishment of cell polarity involved in ameboidal cell migration
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.
has OBO namespace: biological_process
id: GO:0003365
type: Class
subclass of: GO_0030010
subclass of: Restriction
  on property: part_of
  some values from: ameboidal cell migration

cell-matrix adhesion involved in ameboidal cell migration
IAO_0000115: The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.
has OBO namespace: biological_process
id: GO:0003366
type: Class
subclass of: GO_0007160
subclass of: Restriction
  on property: part_of
  some values from: ameboidal cell migration

cell-cell adhesion involved in ameboidal cell migration
IAO_0000115: The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells.
has OBO namespace: biological_process
id: GO:0003367
type: Class
subclass of: GO_0016337
subclass of: Restriction
  on property: part_of
  some values from: establishment of cell polarity involved in ameboidal cell migration

cell-matrix adhesion involved in mesendodermal cell migration
IAO_0000115: The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell.
has OBO namespace: biological_process
id: GO:0003368
type: Class
subclass of: cell-matrix adhesion involved in ameboidal cell migration
subclass of: Restriction
  on property: part_of
  some values from: GO_0090134

establishment of cell polarity involved in mesendodermal cell migration
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell.
has OBO namespace: biological_process
id: GO:0003369
type: Class
subclass of: establishment of cell polarity involved in gastrulation cell migration
subclass of: Restriction
  on property: part_of
  some values from: GO_0090134

cell-cell adhesion involved in mesendodermal cell migration
IAO_0000115: The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm.
has OBO namespace: biological_process
id: GO:0003370
type: Class
subclass of: cell-cell adhesion involved in ameboidal cell migration
subclass of: GO_0070586
subclass of: Restriction
  on property: part_of
  some values from: establishment of cell polarity involved in mesendodermal cell migration

establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.
has OBO namespace: biological_process
id: GO:0003371
type: Class
subclass of: GO_0030952
subclass of: Restriction
  on property: part_of
  some values from: establishment of cell polarity involved in ameboidal cell migration
subclass of: Restriction
  on property: part_of
  some values from: ameboidal cell migration

establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.
has OBO namespace: biological_process
id: GO:0003372
type: Class
subclass of: establishment or maintenance of cytoskeleton polarity involved in gastrulation
subclass of: Restriction
  on property: part_of
  some values from: GO_0090134
subclass of: Restriction
  on property: part_of
  some values from: establishment of cell polarity involved in mesendodermal cell migration

dynamin polymerization involved in membrane fission
IAO_0000115: The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission.
has OBO namespace: biological_process
id: GO:0003373
type: Class
subclass of: GO_0051258
subclass of: Restriction
  on property: part_of
  some values from: GO_0090148

dynamin polymerization involved in mitochondrial fission
IAO_0000115: The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission.
has OBO namespace: biological_process
id: GO:0003374
type: Class
subclass of: dynamin polymerization involved in membrane fission

regulation of dynamin polymerization involved in membrane fission
IAO_0000115: Any process that modulates the rate, frequency, or extent of membrane fission.
has OBO namespace: biological_process
id: GO:0003375
type: Class
subclass of: GO_0032271
subclass of: Restriction
  on property: RO_0002211
  some values from: dynamin polymerization involved in membrane fission

sphingosine-1-phosphate signaling pathway
IAO_0000115: A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
has broad synonym: sphingolipid signaling pathway
has broad synonym: sphingolipid signalling pathway
has db xref: Reactome:REACT_18416.2
has exact synonym: S1P receptor signaling pathway
has exact synonym: S1P signaling pathway
has exact synonym: S1P-activated G-protein coupled receptor signaling pathway
has exact synonym: S1P-activated GPCR signaling pathway
has exact synonym: S1P-stimulated signal transduction pathway
has OBO namespace: biological_process
id: GO:0003376
type: Class
comment: Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
subclass of: GO_0007186

regulation of apoptosis by sphingosine-1-phosphate signaling pathway
IAO_0000115: A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis.
has broad synonym: regulation of apoptosis by sphingolipid signaling pathway
has broad synonym: regulation of apoptosis by sphingolipid signalling pathway
has OBO namespace: biological_process
id: GO:0003377
type: Class
subclass of: sphingosine-1-phosphate signaling pathway
subclass of: GO_0042981

regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
IAO_0000115: A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response.
has broad synonym: regulation of inflammatory response by sphingolipid signaling pathway
has broad synonym: regulation of inflammatory response by sphingolipid signalling pathway
has OBO namespace: biological_process
id: GO:0003378
type: Class
subclass of: sphingosine-1-phosphate signaling pathway
subclass of: GO_0050727

establishment of cell polarity involved in gastrulation cell migration
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.
has OBO namespace: biological_process
id: GO:0003379
type: Class
subclass of: establishment of cell polarity involved in ameboidal cell migration
subclass of: Restriction
  on property: part_of
  some values from: GO_0042074

establishment or maintenance of cytoskeleton polarity involved in gastrulation
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.
has OBO namespace: biological_process
id: GO:0003380
type: Class
subclass of: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
subclass of: Restriction
  on property: part_of
  some values from: establishment of cell polarity involved in gastrulation cell migration
subclass of: Restriction
  on property: part_of
  some values from: GO_0007369

epithelial cell morphogenesis involved in gastrulation
IAO_0000115: The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.
has OBO namespace: biological_process
id: GO:0003381
type: Class
subclass of: epithelial cell morphogenesis
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0007369

epithelial cell morphogenesis
IAO_0000115: The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.
has OBO namespace: biological_process
id: GO:0003382
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: Restriction
  on property: part_of
  some values from: epithelial cell development

apical constriction
IAO_0000115: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.
has OBO namespace: biological_process
id: GO:0003383
type: Class
subclass of: GO_0070252
subclass of: Restriction
  on property: part_of
  some values from: epithelial cell morphogenesis

apical constriction involved in gastrulation
IAO_0000115: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.
has OBO namespace: biological_process
id: GO:0003384
type: Class
subclass of: apical constriction
subclass of: Restriction
  on property: part_of
  some values from: GO_0007369
subclass of: Restriction
  on property: part_of
  some values from: epithelial cell morphogenesis involved in gastrulation

cell-cell signaling involved in amphid sensory organ development
IAO_0000115: Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state.
has exact synonym: cell-cell signalling involved in amphid sensory organ development
has OBO namespace: biological_process
id: GO:0003385
type: Class
subclass of: GO_0007267
subclass of: Restriction
  on property: part_of
  some values from: amphid sensory organ development

amphid sensory organ development
IAO_0000115: The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes.
has OBO namespace: biological_process
id: GO:0003386
type: Class
subclass of: GO_0007423

neuron differentiation involved in amphid sensory organ development
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland.
has OBO namespace: biological_process
id: GO:0003387
type: Class
subclass of: GO_0030182
subclass of: Restriction
  on property: part_of
  some values from: amphid sensory organ development

neuron development involved in amphid sensory organ development
IAO_0000115: The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ.
has OBO namespace: biological_process
id: GO:0003388
type: Class
subclass of: GO_0048666
subclass of: Restriction
  on property: part_of
  some values from: neuron differentiation involved in amphid sensory organ development
subclass of: Restriction
  on property: part_of
  some values from: amphid sensory organ development

retrograde extension
IAO_0000115: The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.
has OBO namespace: biological_process
id: GO:0003389
type: Class
subclass of: GO_0031175

dendrite development by retrograde extension
IAO_0000115: The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point.
has exact synonym: dendrite retrograde extension
has OBO namespace: biological_process
id: GO:0003390
type: Class
subclass of: retrograde extension
subclass of: GO_0016358

amphid sensory organ dendrite retrograde extension
IAO_0000115: The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.
has OBO namespace: biological_process
id: GO:0003391
type: Class
subclass of: dendrite development by retrograde extension
subclass of: Restriction
  on property: part_of
  some values from: neuron development involved in amphid sensory organ development

cell adhesion involved in retrograde extension
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension.
has OBO namespace: biological_process
id: GO:0003392
type: Class
subclass of: GO_0007155
subclass of: Restriction
  on property: part_of
  some values from: retrograde extension

neuron migration involved in retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension.
has OBO namespace: biological_process
id: GO:0003393
type: Class
subclass of: neuron migration
subclass of: Restriction
  on property: part_of
  some values from: retrograde extension

cell adhesion involved in dendrite retrograde extension
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite.
has OBO namespace: biological_process
id: GO:0003394
type: Class
subclass of: cell adhesion involved in retrograde extension
subclass of: Restriction
  on property: part_of
  some values from: dendrite development by retrograde extension

neuron migration involved in dendrite retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite.
has OBO namespace: biological_process
id: GO:0003395
type: Class
subclass of: neuron migration involved in retrograde extension
subclass of: Restriction
  on property: part_of
  some values from: dendrite development by retrograde extension

cell adhesion involved in amphid sensory organ dendrite retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ.
has OBO namespace: biological_process
id: GO:0003396
type: Class
subclass of: cell adhesion involved in dendrite retrograde extension
subclass of: Restriction
  on property: part_of
  some values from: amphid sensory organ dendrite retrograde extension

neuron migration involved in amphid sensory organ dendrite retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ.
has OBO namespace: biological_process
id: GO:0003397
type: Class
subclass of: neuron migration involved in dendrite retrograde extension
subclass of: Restriction
  on property: part_of
  some values from: amphid sensory organ dendrite retrograde extension

glial cell differentiation involved in amphid sensory organ development
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ.
has OBO namespace: biological_process
id: GO:0003398
type: Class
subclass of: GO_0010001
subclass of: Restriction
  on property: part_of
  some values from: amphid sensory organ development

cytoneme morphogenesis
IAO_0000115: The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell.
has OBO namespace: biological_process
id: GO:0003399
type: Class
subclass of: GO_0048858

regulation of COPII vesicle coating
IAO_0000115: Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
has OBO namespace: biological_process
id: GO:0003400
type: Class
subclass of: GO_0033043
subclass of: GO_0048209
subclass of: GO_0090113
subclass of: Restriction
  on property: RO_0002211
  some values from: GO_0048208

axis elongation
IAO_0000115: The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.
has OBO namespace: biological_process
has related synonym: elongation of an axis
id: GO:0003401
type: Class
subclass of: GO_0060560

planar cell polarity pathway involved in axis elongation
IAO_0000115: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.
has OBO namespace: biological_process
id: GO:0003402
type: Class
subclass of: GO_0060071
subclass of: Restriction
  on property: part_of
  some values from: axis elongation

optic vesicle formation
IAO_0000115: The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
has OBO namespace: biological_process
id: GO:0003403
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0060900
subclass of: Restriction
  on property: part_of
  some values from: optic vesicle morphogenesis

optic vesicle morphogenesis
IAO_0000115: The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
has OBO namespace: biological_process
id: GO:0003404
type: Class
subclass of: GO_0048598
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0048596

optic vesicle elongation
IAO_0000115: The developmental growth that results in the lengthening of the optic vesicle in the posterior direction.
has OBO namespace: biological_process
id: GO:0003405
type: Class
subclass of: GO_0060560
subclass of: Restriction
  on property: part_of
  some values from: optic vesicle morphogenesis

retinal pigment epithelium development
IAO_0000115: The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
has OBO namespace: biological_process
has related synonym: RPE development
id: GO:0003406
type: Class
subclass of: GO_0060429
subclass of: Restriction
  on property: part_of
  some values from: GO_0060041

neural retina development
IAO_0000115: The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
has OBO namespace: biological_process
id: GO:0003407
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0060041

optic cup formation involved in camera-type eye development
IAO_0000115: The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.
has OBO namespace: biological_process
id: GO:0003408
type: Class
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: optic cup morphogenesis involved in camera-type eye development

optic cup structural organization
IAO_0000115: The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure.
has exact synonym: optic cup structural organisation
has OBO namespace: biological_process
id: GO:0003409
type: Class
subclass of: GO_0048532
subclass of: Restriction
  on property: part_of
  some values from: optic cup morphogenesis involved in camera-type eye development

anterior rotation of the optic cup
IAO_0000115: A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis.
has OBO namespace: biological_process
id: GO:0003410
type: Class
subclass of: GO_0048856
subclass of: Restriction
  on property: part_of
  some values from: GO_0043010

cell motility involved in camera-type eye morphogenesis
IAO_0000115: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.
has OBO namespace: biological_process
id: GO:0003411
type: Class
subclass of: GO_0048870
subclass of: Restriction
  on property: part_of
  some values from: GO_0048593

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
IAO_0000115: The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.
has OBO namespace: biological_process
id: GO:0003412
type: Class
subclass of: GO_0045198
subclass of: Restriction
  on property: part_of
  some values from: GO_0048593

chondrocyte differentiation involved in endochondral bone morphogenesis
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
has OBO namespace: biological_process
id: GO:0003413
type: Class
subclass of: chondrocyte differentiation
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0060350
subclass of: Restriction
  on property: part_of
  some values from: GO_0060351

chondrocyte morphogenesis involved in endochondral bone morphogenesis
IAO_0000115: The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.
has OBO namespace: biological_process
id: GO:0003414
type: Class
subclass of: GO_0048646
subclass of: GO_0090171
subclass of: Restriction
  on property: part_of
  some values from: chondrocyte development involved in endochondral bone morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: GO_0060350

chondrocyte hypertrophy
IAO_0000115: The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time.
has OBO namespace: biological_process
id: GO:0003415
type: Class
subclass of: GO_0048588
subclass of: Restriction
  on property: part_of
  some values from: chondrocyte development

endochondral bone growth
IAO_0000115: The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.
has OBO namespace: biological_process
id: GO:0003416
type: Class
subclass of: GO_0060560
subclass of: Restriction
  on property: part_of
  some values from: GO_0060350

growth plate cartilage development
IAO_0000115: The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.
has OBO namespace: biological_process
id: GO:0003417
type: Class
subclass of: GO_0060351
subclass of: Restriction
  on property: part_of
  some values from: endochondral bone growth

growth plate cartilage chondrocyte differentiation
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
has OBO namespace: biological_process
id: GO:0003418
type: Class
subclass of: chondrocyte differentiation involved in endochondral bone morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage development

growth plate cartilage chondrocyte proliferation
IAO_0000115: The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
has OBO namespace: biological_process
id: GO:0003419
type: Class
subclass of: GO_0008283
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage development

regulation of growth plate cartilage chondrocyte proliferation
IAO_0000115: Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
has OBO namespace: biological_process
id: GO:0003420
type: Class
subclass of: GO_0042127
subclass of: GO_0048638
subclass of: GO_0061035
subclass of: GO_2000027
subclass of: Restriction
  on property: RO_0002211
  some values from: growth plate cartilage chondrocyte proliferation

growth plate cartilage axis specification
IAO_0000115: The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth.
has OBO namespace: biological_process
has related synonym: growth plate cartilage axis determination
id: GO:0003421
type: Class
subclass of: GO_0009798
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage morphogenesis

growth plate cartilage morphogenesis
IAO_0000115: The process in which the anatomical structures of cartilage are generated and organized.
has OBO namespace: biological_process
id: GO:0003422
type: Class
subclass of: GO_0060536
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage development

growth plate cartilage chondrocyte division
IAO_0000115: The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate.
has OBO namespace: biological_process
id: GO:0003423
type: Class
subclass of: GO_0051301
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte proliferation

establishment of cell polarity involved in growth plate cartilage chondrocyte division
IAO_0000115: The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte.
has OBO namespace: biological_process
has related synonym: growth plate cartilage chondrocyte polarization
id: GO:0003424
type: Class
subclass of: establishment of planar polarity
subclass of: GO_0030010
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte division

establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
IAO_0000115: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate.
has OBO namespace: biological_process
id: GO:0003425
type: Class
subclass of: establishment of mitotic spindle orientation
subclass of: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
subclass of: GO_0090176
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte division

cytoskeleton polarization involved in growth plate cartilage chondrocyte division
IAO_0000115: A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.
has OBO namespace: biological_process
id: GO:0003426
type: Class
subclass of: GO_0030952
subclass of: Restriction
  on property: part_of
  some values from: establishment of cell polarity involved in growth plate cartilage chondrocyte division

regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
IAO_0000115: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.
has exact synonym: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway
has OBO namespace: biological_process
id: GO:0003427
type: Class
subclass of: regulation of growth plate cartilage chondrocyte proliferation
subclass of: GO_0051302
subclass of: GO_0051493
subclass of: GO_0060071
subclass of: GO_2000114
subclass of: Restriction
  on property: RO_0002211
  some values from: cytoskeleton polarization involved in growth plate cartilage chondrocyte division

chondrocyte intercalation involved in growth plate cartilage morphogenesis
IAO_0000115: The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.
has OBO namespace: biological_process
id: GO:0003428
type: Class
subclass of: GO_0016477
subclass of: Restriction
  on property: part_of
  some values from: GO_0060029
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage morphogenesis

growth plate cartilage chondrocyte morphogenesis
IAO_0000115: The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.
has OBO namespace: biological_process
id: GO:0003429
type: Class
subclass of: chondrocyte morphogenesis involved in endochondral bone morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte differentiation

growth plate cartilage chondrocyte growth
IAO_0000115: The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.
has exact synonym: growth plate cartilage chondrocyte hypertrophy
has OBO namespace: biological_process
id: GO:0003430
type: Class
subclass of: chondrocyte hypertrophy
subclass of: GO_0060560
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte development

growth plate cartilage chondrocyte development
IAO_0000115: The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell.
has OBO namespace: biological_process
id: GO:0003431
type: Class
subclass of: chondrocyte development involved in endochondral bone morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte differentiation

cell growth involved in growth plate cartilage chondrocyte morphogenesis
IAO_0000115: The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time.
has OBO namespace: biological_process
id: GO:0003432
type: Class
subclass of: growth plate cartilage chondrocyte growth
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte morphogenesis

chondrocyte development involved in endochondral bone morphogenesis
IAO_0000115: The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.
has OBO namespace: biological_process
id: GO:0003433
type: Class
subclass of: chondrocyte development
subclass of: GO_0048646
subclass of: Restriction
  on property: part_of
  some values from: GO_0060350
subclass of: Restriction
  on property: part_of
  some values from: chondrocyte differentiation involved in endochondral bone morphogenesis

BMP signaling pathway involved in growth plate cartilage chondrocyte development
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.
has exact synonym: BMP signalling pathway involved in growth plate cartilage chondrocyte development
has OBO namespace: biological_process
id: GO:0003434
type: Class
subclass of: GO_0030509
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte development

smoothened signaling pathway involved in growth plate cartilage chondrocyte development
IAO_0000115: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time.
has exact synonym: hedgehog signaling pathway involved in growth plate cartilage chondrocyte development
has exact synonym: hh signaling pathway involved in growth plate cartilage chondrocyte development
has exact synonym: smoothened signalling pathway involved in growth plate cartilage chondrocyte development
has OBO namespace: biological_process
id: GO:0003435
type: Class
subclass of: GO_0007224
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage chondrocyte development

regulation of cell adhesion involved in growth plate cartilage morphogenesis
IAO_0000115: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone.
has OBO namespace: biological_process
id: GO:0003436
type: Class
subclass of: GO_0030155
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage morphogenesis

regulation of cell communication involved in growth plate cartilage morphogenesis
IAO_0000115: Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage.
has OBO namespace: biological_process
id: GO:0003437
type: Class
subclass of: GO_0010646
subclass of: Restriction
  on property: part_of
  some values from: growth plate cartilage morphogenesis

Gene_Ontology
IAO_0000115: OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes.
has OBO namespace: biological_process
id: GO:0003673
type: Class
comment: This term was made obsolete because more specific terms were created.
deprecated: true

molecular_function
IAO_0000115: Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
has alternative id: GO:0005554
has exact synonym: molecular function
has narrow synonym: molecular function unknown
has OBO namespace: molecular_function
id: GO:0003674
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast
in subset: gosubset prok
type: Class
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
disjoint with: GO_0005575
disjoint with: GO_0008150

protein
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: cellular_component
id: GO:0003675
type: Class
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
deprecated: true

nucleic acid binding
IAO_0000115: Interacting selectively and non-covalently with any nucleic acid.
has OBO namespace: molecular_function
id: GO:0003676
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: gosubset prok
type: Class
subclass of: GO_0097159
subclass of: GO_1901363

DNA binding
IAO_0000115: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has narrow synonym: plasmid binding
has OBO namespace: molecular_function
has related synonym: microtubule/chromatin interaction
id: GO:0003677
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim generic
in subset: goslim plant
in subset: goslim yeast
in subset: gosubset prok
type: Class
subclass of: nucleic acid binding

DNA helicase activity
IAO_0000115: Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
has alternative id: GO:0003679
has db xref: Reactome:REACT_116013
has OBO namespace: molecular_function
id: GO:0003678
in subset: gosubset prok
type: Class
subclass of: helicase activity

AT DNA binding
IAO_0000115: Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
has exact synonym: AT binding
has OBO namespace: molecular_function
id: GO:0003680
type: Class
subclass of: GO_0043565

bent DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA in a bent conformation.
has OBO namespace: molecular_function
id: GO:0003681
in subset: gosubset prok
type: Class
subclass of: GO_0043566

chromatin binding
IAO_0000115: Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
has broad synonym: lamin/chromatin binding
has narrow synonym: nuclear membrane vesicle binding to chromatin
has OBO namespace: molecular_function
has related synonym: microtubule/chromatin interaction
id: GO:0003682
in subset: goslim pir
in subset: goslim plant
type: Class
subclass of: GO_0005488

lamin/chromatin binding
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0003682
IAO_0100001: GO:0005521
has OBO namespace: molecular_function
id: GO:0003683
type: Class
comment: This term was made obsolete because it represents two functions.
deprecated: true

damaged DNA binding
IAO_0000115: Interacting selectively and non-covalently with damaged DNA.
has db xref: Reactome:REACT_100664
has db xref: Reactome:REACT_101048
has db xref: Reactome:REACT_101116
has db xref: Reactome:REACT_103019
has db xref: Reactome:REACT_103328
has db xref: Reactome:REACT_103380
has db xref: Reactome:REACT_103899
has db xref: Reactome:REACT_104175
has db xref: Reactome:REACT_104346
has db xref: Reactome:REACT_105157
has db xref: Reactome:REACT_105628
has db xref: Reactome:REACT_106525
has db xref: Reactome:REACT_110972
has db xref: Reactome:REACT_110979
has db xref: Reactome:REACT_113582
has db xref: Reactome:REACT_113713
has db xref: Reactome:REACT_113838
has db xref: Reactome:REACT_114851
has db xref: Reactome:REACT_1435
has db xref: Reactome:REACT_1696
has db xref: Reactome:REACT_1934
has db xref: Reactome:REACT_2185
has db xref: Reactome:REACT_28366
has db xref: Reactome:REACT_29673
has db xref: Reactome:REACT_30891
has db xref: Reactome:REACT_31436
has db xref: Reactome:REACT_33416
has db xref: Reactome:REACT_33600
has db xref: Reactome:REACT_33888
has db xref: Reactome:REACT_462
has db xref: Reactome:REACT_52866
has db xref: Reactome:REACT_77587
has db xref: Reactome:REACT_783
has db xref: Reactome:REACT_79824
has db xref: Reactome:REACT_81071
has db xref: Reactome:REACT_81112
has db xref: Reactome:REACT_81735
has db xref: Reactome:REACT_82167
has db xref: Reactome:REACT_83944
has db xref: Reactome:REACT_84763
has db xref: Reactome:REACT_84781
has db xref: Reactome:REACT_84951
has db xref: Reactome:REACT_85779
has db xref: Reactome:REACT_86067
has db xref: Reactome:REACT_87009
has db xref: Reactome:REACT_88774
has db xref: Reactome:REACT_88901
has db xref: Reactome:REACT_89666
has db xref: Reactome:REACT_89685
has db xref: Reactome:REACT_89917
has db xref: Reactome:REACT_90545
has db xref: Reactome:REACT_91221
has db xref: Reactome:REACT_91729
has db xref: Reactome:REACT_91817
has db xref: Reactome:REACT_92004
has db xref: Reactome:REACT_92429
has db xref: Reactome:REACT_93699
has db xref: Reactome:REACT_93716
has db xref: Reactome:REACT_93739
has db xref: Reactome:REACT_94142
has db xref: Reactome:REACT_94682
has db xref: Reactome:REACT_95130
has db xref: Reactome:REACT_97138
has db xref: Reactome:REACT_97358
has db xref: Reactome:REACT_98435
has db xref: Reactome:REACT_98953
has OBO namespace: molecular_function
has related synonym: DNA repair enzyme
has related synonym: DNA repair protein
id: GO:0003684
in subset: gosubset prok
type: Class
subclass of: DNA binding

DNA repair protein
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0003684
has OBO namespace: molecular_function
id: GO:0003685
type: Class
comment: This term was made obsolete because it includes a process term.
deprecated: true

DNA repair enzyme
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0003684
has OBO namespace: molecular_function
id: GO:0003686
type: Class
comment: This term was made obsolete because it includes a process term.
deprecated: true

DNA replication factor
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0006260
has OBO namespace: molecular_function
id: GO:0003687
type: Class
comment: This term was made obsolete because it does not represent a true molecular function.
deprecated: true

DNA replication origin binding
IAO_0000115: Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
has narrow synonym: ARS binding
has OBO namespace: molecular_function
id: GO:0003688
in subset: gosubset prok
type: Class
subclass of: GO_0043565

DNA clamp loader activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex.
has db xref: Reactome:REACT_106382
has db xref: Reactome:REACT_107423
has db xref: Reactome:REACT_113703
has db xref: Reactome:REACT_29764
has db xref: Reactome:REACT_33572
has db xref: Reactome:REACT_50018
has db xref: Reactome:REACT_6729
has db xref: Reactome:REACT_79188
has db xref: Reactome:REACT_88384
has db xref: Reactome:REACT_90809
has db xref: Reactome:REACT_92527
has db xref: Reactome:REACT_92644
has db xref: Reactome:REACT_96998
has exact synonym: DNA clamp loading ATPase activity
has narrow synonym: PCNA loading activity
has narrow synonym: PCNA loading complex activity
has OBO namespace: molecular_function
id: GO:0003689
in subset: gosubset prok
type: Class
subclass of: DNA binding
subclass of: GO_0033170

double-stranded DNA binding
IAO_0000115: Interacting selectively and non-covalently with double-stranded DNA.
has exact synonym: dsDNA binding
has OBO namespace: molecular_function
id: GO:0003690
in subset: gosubset prok
type: Class
subclass of: GO_0043566

double-stranded telomeric DNA binding
IAO_0000115: Interacting selectively and non-covalently with double-stranded telomere-associated DNA.
has OBO namespace: molecular_function
id: GO:0003691
type: Class
subclass of: double-stranded DNA binding
subclass of: GO_0042162

left-handed Z-DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.
has OBO namespace: molecular_function
id: GO:0003692
type: Class
subclass of: GO_0043566

P-element binding
IAO_0000115: Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis.
has OBO namespace: molecular_function
id: GO:0003693
type: Class
subclass of: GO_0043565

plasmid binding
IAO_0000115: OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms.
consider: GO:0003677
consider: GO:0005727
has OBO namespace: molecular_function
has related synonym: plasmid-associated protein
id: GO:0003694
type: Class
comment: This term was made obsolete because it refers to component information.
deprecated: true

random coil DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA in a random coil configuration.
has alternative id: GO:0016017
has exact synonym: random coil binding
has OBO namespace: molecular_function
id: GO:0003695
type: Class
subclass of: GO_0043566

satellite DNA binding
IAO_0000115: Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.
has OBO namespace: molecular_function
id: GO:0003696
type: Class
subclass of: GO_0043565

single-stranded DNA binding
IAO_0000115: Interacting selectively and non-covalently with single-stranded DNA.
has alternative id: GO:0003698
has alternative id: GO:0003699
has exact synonym: ssDNA binding
has OBO namespace: molecular_function
id: GO:0003697
in subset: gosubset prok
type: Class
comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA.
subclass of: GO_0043566

sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has alternative id: GO:0000130
has broad synonym: transcription factor activity
has OBO namespace: molecular_function
id: GO:0003700
in subset: goslim plant
in subset: gosubset prok
type: Class
subclass of: nucleic acid binding transcription factor activity

RNA polymerase I transcription factor activity
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription.
consider: GO:0001082
consider: GO:0001167
consider: GO:0006360
has OBO namespace: molecular_function
id: GO:0003701
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

RNA polymerase II transcription factor activity
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription.
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366
has OBO namespace: molecular_function
id: GO:0003702
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

specific RNA polymerase II transcription factor activity
IAO_0000115: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II.
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366
has OBO namespace: molecular_function
id: GO:0003704
type: Class
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
has exact synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
has OBO namespace: molecular_function
id: GO:0003705
type: Class
subclass of: sequence-specific DNA binding RNA polymerase II transcription factor activity

ligand-regulated transcription factor activity
IAO_0000115: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand.
consider: GO:0004879
consider: GO:0038049
has OBO namespace: molecular_function
id: GO:0003706
type: Class
comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism.
deprecated: true

steroid hormone receptor activity
IAO_0000115: Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
has OBO namespace: molecular_function
id: GO:0003707
type: Class
comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
subclass of: GO_0038023

retinoic acid receptor activity
IAO_0000115: Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A.
has broad synonym: vitamin A receptor activity
has OBO namespace: molecular_function
id: GO:0003708
type: Class
subclass of: GO_0004879

RNA polymerase III transcription factor activity
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription.
consider: GO:0000995
consider: GO:0001007
consider: GO:0001034
consider: GO:0006383
has OBO namespace: molecular_function
id: GO:0003709
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

transcription elongation regulator activity
IAO_0000115: OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.
consider: GO:0032784
has exact synonym: transcription elongation factor activity
has exact synonym: transcriptional elongation regulator activity
has OBO namespace: molecular_function
id: GO:0003711
in subset: gosubset prok
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

transcription cofactor activity
IAO_0000115: Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
has exact synonym: transcriptional co-regulator
has exact synonym: transcriptional cofactor activity
has OBO namespace: molecular_function
id: GO:0003712
in subset: gosubset prok
type: Class
subclass of: transcription factor binding transcription factor activity

transcription coactivator activity
IAO_0000115: Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
has exact synonym: transcription co-activator activity
has OBO namespace: molecular_function
id: GO:0003713
in subset: gosubset prok
type: Class
subclass of: transcription cofactor activity

transcription corepressor activity
IAO_0000115: Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
has exact synonym: transcription co-repressor activity
has OBO namespace: molecular_function
id: GO:0003714
type: Class
subclass of: transcription cofactor activity

transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription.
consider: GO:0006353
has exact synonym: transcriptional termination factor activity
has OBO namespace: molecular_function
id: GO:0003715
in subset: gosubset prok
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

RNA polymerase I transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I.
consider: GO:0006363
has exact synonym: Pol I transcription termination factor activity
has OBO namespace: molecular_function
id: GO:0003716
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

RNA polymerase II transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II.
consider: GO:0006369
has exact synonym: Pol II transcription termination factor activity
has OBO namespace: molecular_function
id: GO:0003717
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

RNA polymerase III transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III.
consider: GO:0006386
has exact synonym: Pol III transcription termination factor activity
has OBO namespace: molecular_function
id: GO:0003718
type: Class
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
deprecated: true

transcription factor binding, cytoplasmic sequestering
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0042994
has OBO namespace: molecular_function
id: GO:0003719
type: Class
comment: This term was made obsolete because sequestering is a process rather than a function.
deprecated: true

telomerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
has db xref: EC:2.7.7.-
has db xref: Reactome:REACT_104705
has db xref: Reactome:REACT_106476
has db xref: Reactome:REACT_108407
has db xref: Reactome:REACT_109443
has db xref: Reactome:REACT_113385
has db xref: Reactome:REACT_114466
has db xref: Reactome:REACT_115824
has db xref: Reactome:REACT_116122
has db xref: Reactome:REACT_28249
has db xref: Reactome:REACT_30494
has db xref: Reactome:REACT_30995
has db xref: Reactome:REACT_31549
has db xref: Reactome:REACT_33436
has db xref: Reactome:REACT_77280
has db xref: Reactome:REACT_7985
has db xref: Reactome:REACT_8019
has db xref: Reactome:REACT_80834
has db xref: Reactome:REACT_81691
has db xref: Reactome:REACT_83982
has db xref: Reactome:REACT_85286
has db xref: Reactome:REACT_86666
has db xref: Reactome:REACT_90823
has db xref: Reactome:REACT_93232
has db xref: Reactome:REACT_94534
has db xref: Reactome:REACT_94768
has db xref: Reactome:REACT_95176
has db xref: Reactome:REACT_96912
has db xref: Reactome:REACT_97770
has OBO namespace: molecular_function
id: GO:0003720
type: Class
subclass of: RNA-directed DNA polymerase activity

telomeric template RNA reverse transcriptase activity
IAO_0000115: Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.
has exact synonym: telomerase, catalyst
has OBO namespace: molecular_function
id: GO:0003721
type: Class
subclass of: RNA-directed DNA polymerase activity
subclass of: Restriction
  on property: part_of
  some values from: telomerase activity

RNA binding
IAO_0000115: Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
has db xref: Reactome:REACT_101703
has db xref: Reactome:REACT_103323
has db xref: Reactome:REACT_106430
has db xref: Reactome:REACT_107757
has db xref: Reactome:REACT_108232
has db xref: Reactome:REACT_108368
has db xref: Reactome:REACT_109723
has db xref: Reactome:REACT_12458
has db xref: Reactome:REACT_29965
has db xref: Reactome:REACT_77167
has db xref: Reactome:REACT_78197
has db xref: Reactome:REACT_87164
has db xref: Reactome:REACT_89329
has db xref: Reactome:REACT_90531
has db xref: Reactome:REACT_98683
has OBO namespace: molecular_function
id: GO:0003723
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim generic
in subset: goslim plant
in subset: goslim yeast
in subset: gosubset prok
type: Class
subclass of: nucleic acid binding

RNA helicase activity
IAO_0000115: Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix.
has db xref: EC:2.7.7.-
has db xref: Reactome:REACT_110845
has db xref: Reactome:REACT_112817
has db xref: Reactome:REACT_1521
has db xref: Reactome:REACT_31034
has db xref: Reactome:REACT_84574
has db xref: Reactome:REACT_85111
has db xref: Reactome:REACT_98745
has OBO namespace: molecular_function
id: GO:0003724
in subset: gosubset prok
type: Class
subclass of: helicase activity

double-stranded RNA binding
IAO_0000115: Interacting selectively and non-covalently with double-stranded RNA.
has exact synonym: dsRNA binding
has OBO namespace: molecular_function
id: GO:0003725
in subset: gosubset prok
type: Class
subclass of: RNA binding

double-stranded RNA adenosine deaminase activity
IAO_0000115: Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
has alternative id: GO:0003971
has db xref: Reactome:REACT_100080
has db xref: Reactome:REACT_104541
has db xref: Reactome:REACT_110356
has db xref: Reactome:REACT_1105
has db xref: Reactome:REACT_112019
has db xref: Reactome:REACT_112024
has db xref: Reactome:REACT_113770
has db xref: Reactome:REACT_114900
has db xref: Reactome:REACT_115470
has db xref: Reactome:REACT_29892
has db xref: Reactome:REACT_31966
has db xref: Reactome:REACT_32015
has db xref: Reactome:REACT_365
has db xref: Reactome:REACT_79183
has db xref: Reactome:REACT_79641
has db xref: Reactome:REACT_80597
has db xref: Reactome:REACT_80662
has db xref: Reactome:REACT_86066
has db xref: Reactome:REACT_86370
has db xref: Reactome:REACT_86554
has db xref: Reactome:REACT_87527
has db xref: Reactome:REACT_90605
has db xref: Reactome:REACT_90645
has db xref: Reactome:REACT_92526
has db xref: Reactome:REACT_99543
has db xref: Reactome:REACT_99769
has OBO namespace: molecular_function
has related synonym: double-stranded RNA specific editase activity
id: GO:0003726
in subset: gosubset prok
type: Class
subclass of: adenosine deaminase activity

single-stranded RNA binding
IAO_0000115: Interacting selectively and non-covalently with single-stranded RNA.
has alternative id: GO:0003728
has exact synonym: ssRNA binding
has OBO namespace: molecular_function
id: GO:0003727
type: Class
subclass of: RNA binding

mRNA binding
IAO_0000115: Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
has OBO namespace: molecular_function
id: GO:0003729
in subset: goslim generic
in subset: goslim yeast
in subset: gosubset prok
type: Class
subclass of: RNA binding

mRNA 3'-UTR binding
IAO_0000115: Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
has exact synonym: mRNA 3' UTR binding
has OBO namespace: molecular_function
id: GO:0003730
type: Class
subclass of: mRNA binding

mRNA cap binding
IAO_0000115: OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript.
consider: GO:0000339
has OBO namespace: molecular_function
id: GO:0003731
type: Class
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
deprecated: true

snRNA cap binding
IAO_0000115: OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule.
consider: GO:0000339
has OBO namespace: molecular_function
id: GO:0003732
type: Class
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
deprecated: true

ribonucleoprotein
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0030529
has OBO namespace: molecular_function
id: GO:0003733
type: Class
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
deprecated: true

small nuclear ribonucleoprotein
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0030532
has exact synonym: snRNP
has OBO namespace: molecular_function
id: GO:0003734
type: Class
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
deprecated: true

structural constituent of ribosome
IAO_0000115: The action of a molecule that contributes to the structural integrity of the ribosome.
has alternative id: GO:0003736
has alternative id: GO:0003737
has alternative id: GO:0003738
has alternative id: GO:0003739
has alternative id: GO:0003740
has alternative id: GO:0003741
has alternative id: GO:0003742
has broad synonym: ribosomal protein
has OBO namespace: molecular_function
has related synonym: ribosomal RNA
id: GO:0003735
in subset: goslim generic
in subset: goslim yeast
in subset: gosubset prok
type: Class
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.
subclass of: GO_0005198

translation initiation factor activity
IAO_0000115: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
has alternative id: GO:0003744
has alternative id: GO:0003745
has db xref: Reactome:REACT_102411
has db xref: Reactome:REACT_102747
has db xref: Reactome:REACT_104592
has db xref: Reactome:REACT_104947
has db xref: Reactome:REACT_105336
has db xref: Reactome:REACT_105545
has db xref: Reactome:REACT_105772
has db xref: Reactome:REACT_106049
has db xref: Reactome:REACT_107324
has db xref: Reactome:REACT_108980
has db xref: Reactome:REACT_112013
has db xref: Reactome:REACT_114676
has db xref: Reactome:REACT_115071
has db xref: Reactome:REACT_115079
has db xref: Reactome:REACT_115451
has db xref: Reactome:REACT_1401
has db xref: Reactome:REACT_1516
has db xref: Reactome:REACT_29285
has db xref: Reactome:REACT_31248
has db xref: Reactome:REACT_31637
has db xref: Reactome:REACT_32686
has db xref: Reactome:REACT_33398
has db xref: Reactome:REACT_33544
has db xref: Reactome:REACT_57036
has db xref: Reactome:REACT_60464
has db xref: Reactome:REACT_656
has db xref: Reactome:REACT_78159
has db xref: Reactome:REACT_78773
has db xref: Reactome:REACT_79007
has db xref: Reactome:REACT_81171
has db xref: Reactome:REACT_82224
has db xref: Reactome:REACT_83059
has db xref: Reactome:REACT_83547
has db xref: Reactome:REACT_83592
has db xref: Reactome:REACT_88632
has db xref: Reactome:REACT_88913
has db xref: Reactome:REACT_88955
has db xref: Reactome:REACT_91084
has db xref: Reactome:REACT_91415
has db xref: Reactome:REACT_91967
has db xref: Reactome:REACT_91979
has db xref: Reactome:REACT_93372
has db xref: Reactome:REACT_93678
has db xref: Reactome:REACT_95840
has db xref: Reactome:REACT_96533
has db xref: Reactome:REACT_96726
has db xref: Reactome:REACT_99607
has OBO namespace: molecular_function
id: GO:0003743
in subset: gosubset prok
type: Class
subclass of: GO_0008135

translation elongation factor activity
IAO_0000115: Functions in chain elongation during polypeptide synthesis at the ribosome.
has alternative id: GO:0008182
has alternative id: GO:0008183
has db xref: Reactome:REACT_9514
has db xref: Reactome:REACT_9524
has OBO namespace: molecular_function
id: GO:0003746
in subset: gosubset prok
type: Class
subclass of: GO_0008135

translation release factor activity
IAO_0000115: Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
has alternative id: GO:0003748
has alternative id: GO:0003749
has OBO namespace: molecular_function
id: GO:0003747
in subset: gosubset prok
type: Class
subclass of: GO_0008079

cell cycle regulator
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0051726
has OBO namespace: molecular_function
id: GO:0003750
type: Class
comment: This term was made obsolete because it does not represent a single molecular function.
deprecated: true

chaperone activity
IAO_0000115: OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function.
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082
has alternative id: GO:0003757
has alternative id: GO:0003758
has alternative id: GO:0003760
has alternative id: GO:0003761
has OBO namespace: molecular_function
id: GO:0003754
type: Class
comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes.
deprecated: true

peptidyl-prolyl cis-trans isomerase activity
IAO_0000115: Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
has alternative id: GO:0004752
has alternative id: GO:0042028
has db xref: EC:5.2.1.8
has db xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
has exact synonym: PPIase activity
has exact synonym: cis-trans proline isomerase activity
has exact synonym: peptide bond isomerase activity
has exact synonym: peptidylproline cis-trans-isomerase activity
has exact synonym: peptidylprolyl cis-trans isomerase activity
has exact synonym: peptidylprolyl isomerase activity
has exact synonym: rotamase activity
has narrow synonym: FK506-sensitive peptidyl-prolyl cis-trans isomerase
has narrow synonym: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
has narrow synonym: juglone-sensitive cis-trans proline isomerase activity
has narrow synonym: juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
has OBO namespace: molecular_function
has related synonym: cyclophilin activity
has related synonym: immunophilin
has related synonym: parvulin
has related synonym: peptidyl-prolyl isomerase B reaction
id: GO:0003755
in subset: gosubset prok
type: Class
subclass of: GO_0016859

protein disulfide isomerase activity
IAO_0000115: Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
has alternative id: GO:0006467
has broad synonym: protein disulfide-isomerase
has db xref: EC:5.3.4.1
has db xref: MetaCyc:5.3.4.1-RXN
has exact synonym: disulphide bond biosynthesis
has exact synonym: disulphide bond formation
has exact synonym: protein disulfide-isomerase reaction
has exact synonym: protein disulphide isomerase activity
has exact synonym: protein thiol-disulfide exchange
has exact synonym: protein thiol-disulphide exchange
has OBO namespace: molecular_function
has related synonym: S-S rearrangase activity
has related synonym: protein cysteine-thiol oxidation
id: GO:0003756
in subset: gosubset prok
type: Class
subclass of: GO_0016862
subclass of: GO_0016864

glycoprotein-specific chaperone activity
IAO_0000115: OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins.
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082
has OBO namespace: molecular_function
id: GO:0003759
type: Class
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
deprecated: true

histone-specific chaperone activity
IAO_0000115: OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function.
consider: GO:0006333
consider: GO:0006334
consider: GO:0034728
consider: GO:0042393
consider: GO:0043486
consider: GO:0044183
consider: GO:0051082
has exact synonym: nucleosome assembly chaperone
has OBO namespace: molecular_function
id: GO:0003762
type: Class
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
deprecated: true

chaperonin ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.
IAO_0100001: GO:0042623
consider: GO:0006457
has alternative id: GO:0003764
has alternative id: GO:0003765
has alternative id: GO:0003766
has exact synonym: chaperonin
has OBO namespace: molecular_function
id: GO:0003763
type: Class
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
deprecated: true

co-chaperone activity
IAO_0000115: OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity.
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087
has alternative id: GO:0003768
has alternative id: GO:0003769
has alternative id: GO:0003770
has alternative id: GO:0003771
has OBO namespace: molecular_function
id: GO:0003767
type: Class
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
deprecated: true

co-chaperonin activity
IAO_0000115: OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity.
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087
has OBO namespace: molecular_function
id: GO:0003772
type: Class
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
deprecated: true

heat shock protein activity
IAO_0000115: OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones.
consider: GO:0006986
consider: GO:0042026
has OBO namespace: molecular_function
id: GO:0003773
type: Class
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
deprecated: true

motor activity
IAO_0000115: Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.
has OBO namespace: molecular_function
id: GO:0003774
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: gosubset prok
type: Class
subclass of: GO_0017111

axonemal motor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0003777
consider: GO:0005930
has OBO namespace: molecular_function
id: GO:0003775
type: Class
comment: This term was made obsolete because it includes cellular component information.
deprecated: true

muscle motor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0000146
consider: GO:0006936
consider: GO:0043292
has OBO namespace: molecular_function
id: GO:0003776
type: Class
comment: This term was made obsolete because it includes anatomy information.
deprecated: true

microtubule motor activity
IAO_0000115: Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
has broad synonym: dynein
has broad synonym: kinesin
has db xref: Reactome:REACT_102513
has db xref: Reactome:REACT_103791
has db xref: Reactome:REACT_105852
has db xref: Reactome:REACT_106252
has db xref: Reactome:REACT_113466
has db xref: Reactome:REACT_115371
has db xref: Reactome:REACT_12385
has db xref: Reactome:REACT_15477
has db xref: Reactome:REACT_20570
has db xref: Reactome:REACT_31982
has db xref: Reactome:REACT_32872
has db xref: Reactome:REACT_33543
has db xref: Reactome:REACT_77014
has db xref: Reactome:REACT_78584
has db xref: Reactome:REACT_86678
has db xref: Reactome:REACT_87390
has db xref: Reactome:REACT_89365
has db xref: Reactome:REACT_92428
has db xref: Reactome:REACT_94549
has db xref: Reactome:REACT_95164
has narrow synonym: axonemal motor activity
has narrow synonym: dynein ATPase activity
has narrow synonym: kinesin motor activity
has narrow synonym: kinetochore motor activity
has OBO namespace: molecular_function
id: GO:0003777
type: Class
comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'.
subclass of: motor activity

dynactin motor
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0003778
type: Class
comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex.
deprecated: true

actin binding
IAO_0000115: Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
has narrow synonym: membrane associated actin binding
has OBO namespace: molecular_function
id: GO:0003779
type: Class
subclass of: GO_0008092

actin cross-linking activity
IAO_0000115: OBSOLETE. Interacting selectively with two actin filaments to anchor them together.
IAO_0100001: GO:0030674
IAO_0100001: GO:0051015
has OBO namespace: molecular_function
id: GO:0003780
type: Class
comment: This term was made obsolete because it represents a combination of molecular functions.
deprecated: true

actin bundling activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0051017
has OBO namespace: molecular_function
id: GO:0003781
type: Class
comment: This term was made obsolete because it represents a biological process.
deprecated: true

F-actin capping activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0051016
has OBO namespace: molecular_function
id: GO:0003782
type: Class
comment: This term was made obsolete because it describes a biological process.
deprecated: true

barbed-end actin capping activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0051016
has OBO namespace: molecular_function
id: GO:0003783
type: Class
comment: This term was made obsolete because it describes a biological process.
deprecated: true

barbed-end actin capping/severing activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0051014
IAO_0100001: GO:0051016
has OBO namespace: molecular_function
id: GO:0003784
type: Class
comment: This term was made obsolete because it describes two biological processes.
deprecated: true

actin monomer binding
IAO_0000115: Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
has exact synonym: G actin binding
has OBO namespace: molecular_function
id: GO:0003785
type: Class
subclass of: actin binding

actin lateral binding
IAO_0000115: Interacting selectively and non-covalently with an actin filament along its length.
has OBO namespace: molecular_function
id: GO:0003786
type: Class
subclass of: GO_0051015

actin depolymerizing activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0030042
has OBO namespace: molecular_function
id: GO:0003787
type: Class
comment: This term was made obsolete because it represents a biological process.
deprecated: true

actin monomer sequestering activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0042989
has OBO namespace: molecular_function
id: GO:0003788
type: Class
comment: This term was made obsolete because sequestering is a process, not an activity.
deprecated: true

actin filament severing activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0051014
has OBO namespace: molecular_function
id: GO:0003789
type: Class
comment: This term was made obsolete because it describes a biological process.
deprecated: true

actin modulating activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0030036
has OBO namespace: molecular_function
id: GO:0003790
type: Class
comment: This term was made obsolete because it does not make sense.
deprecated: true

membrane associated actin binding
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0003779
consider: GO:0016020
has OBO namespace: molecular_function
id: GO:0003791
type: Class
comment: This term was made obsolete because it contains both component and function information.
deprecated: true

regulation of actin thin filament length activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0030832
has OBO namespace: molecular_function
id: GO:0003792
type: Class
comment: This term was made obsolete because the term belongs in the process ontology.
deprecated: true

defense/immunity protein activity
IAO_0000115: OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.
consider: GO:0006952
has exact synonym: defence/immunity protein activity
has OBO namespace: molecular_function
id: GO:0003793
type: Class
comment: This term was made obsolete because it refers to involvement in a biological process.
deprecated: true

acute-phase response protein activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0006953
has OBO namespace: molecular_function
id: GO:0003794
type: Class
comment: This term was made obsolete because it refers to involvement in a biological process.
deprecated: true

antimicrobial peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.
consider: GO:0006952
has OBO namespace: molecular_function
id: GO:0003795
type: Class
comment: This term was made obsolete because it describes involvement in a process and not a function.
deprecated: true

lysozyme activity
IAO_0000115: Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
has db xref: EC:3.2.1.17
has db xref: MetaCyc:3.2.1.17-RXN
has exact synonym: 1,4-N-acetylmuramidase activity
has exact synonym: N,O-diacetylmuramidase activity
has exact synonym: mucopeptide N-acetylmuramoylhydrolase activity
has exact synonym: mucopeptide glucohydrolase activity
has exact synonym: muramidase activity
has exact synonym: peptidoglycan N-acetylmuramoylhydrolase activity
has OBO namespace: molecular_function
has related synonym: L-7001
has related synonym: PR1-lysozyme
has related synonym: globulin G
has related synonym: globulin G1
has related synonym: lysozyme g
id: GO:0003796
in subset: gosubset prok
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

antibacterial peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.
consider: GO:0042742
has OBO namespace: molecular_function
id: GO:0003797
type: Class
comment: This term was made obsolete because it describes involvement in a process and not a function.
deprecated: true

male-specific antibacterial peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.
consider: GO:0050831
has OBO namespace: molecular_function
id: GO:0003798
type: Class
comment: This term was made obsolete because it describes involvement in a process and not a function.
deprecated: true

antifungal peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.
consider: GO:0050832
has OBO namespace: molecular_function
id: GO:0003799
type: Class
comment: This term was made obsolete because it describes involvement in a process and not a function.
deprecated: true

antiviral response protein activity
IAO_0000115: OBSOLETE. A protein involved in an antiviral response.
consider: GO:0009615
has OBO namespace: molecular_function
id: GO:0003800
type: Class
comment: This term was made obsolete because it refers to involvement in a biological process.
deprecated: true

blood coagulation factor activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0004252
consider: GO:0007596
has OBO namespace: molecular_function
id: GO:0003801
type: Class
comment: This term was made obsolete because it refers to involvement in a biological process.
deprecated: true

coagulation factor VIIa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.21
has db xref: MetaCyc:3.4.21.21-RXN
has exact synonym: blood coagulation factor VII activity
has OBO namespace: molecular_function
has related synonym: activated blood coagulation factor VII
has related synonym: blood-coagulation factor VIIa
id: GO:0003802
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

coagulation factor IXa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.22
has db xref: MetaCyc:3.4.21.22-RXN
has exact synonym: Christmas factor activity
has exact synonym: blood coagulation factor IX activity
has OBO namespace: molecular_function
has related synonym: activated blood coagulation factor XI
has related synonym: activated blood-coagulation factor IX
has related synonym: activated christmas factor
has related synonym: autoprothrombin II
has related synonym: blood platelet cofactor II
has related synonym: blood-coagulation factor IXa
id: GO:0003803
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

coagulation factor Xa activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.6
has db xref: MetaCyc:3.4.21.6-RXN
has exact synonym: Stuart factor activity
has exact synonym: blood coagulation factor X activity
has exact synonym: prothrombase activity
has exact synonym: prothrombinase activity
has exact synonym: thrombokinase activity
has OBO namespace: molecular_function
has related synonym: Stuart factor
has related synonym: activated Stuart-Prower factor
has related synonym: activated blood-coagulation factor X
has related synonym: activated factor X
has related synonym: autoprothrombin C
has related synonym: factor Xa
has related synonym: plasma thromboplastin
has related synonym: thromboplastin
id: GO:0003804
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

coagulation factor XIa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.27
has db xref: MetaCyc:3.4.21.27-RXN
has exact synonym: blood coagulation factor XI activity
has exact synonym: plasma thromboplastin antecedent activity
has OBO namespace: molecular_function
has related synonym: activated blood-coagulation factor XI
has related synonym: activated plasma thromboplastin antecedent
has related synonym: blood-coagulation factor XIa
id: GO:0003805
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

coagulation factor XIIa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.38
has db xref: MetaCyc:3.4.21.38-RXN
has exact synonym: blood coagulation factor XII activity
has exact synonym: hageman factor activity
has OBO namespace: molecular_function
has related synonym: activated beta blood-coagulation factor XII
has related synonym: blood-coagulation factor XIIabeta
has related synonym: blood-coagulation factor XIIf
has related synonym: hageman factor (activated)
has related synonym: hageman factor beta-fragment
has related synonym: hageman factor fragment HFf
has related synonym: kallikreinogen activator
has related synonym: prealbumin activator
has related synonym: prekallikrein activator
id: GO:0003806
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

plasma kallikrein activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.
IAO_0100001: GO:0004252
has broad synonym: bradykininogenase
has broad synonym: kallidinogenase
has broad synonym: kininogenase
has db xref: EC:3.4.21.34
has db xref: MetaCyc:3.4.21.34-RXN
has exact synonym: serum kallikrein activity
has OBO namespace: molecular_function
has related synonym: callicrein
has related synonym: depot-padutin
has related synonym: dilminal D
has related synonym: glumorin
has related synonym: kallikrein
has related synonym: kallikrein I
has related synonym: kallikrein II
has related synonym: kininogenin activity
has related synonym: onokrein P
has related synonym: padreatin
has related synonym: padutin
has related synonym: panceatic kallikrein
has related synonym: urinary kallikrein
has related synonym: urokallikrein
id: GO:0003807
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

protein C (activated) activity
IAO_0000115: OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.69
has db xref: MetaCyc:3.4.21.69-RXN
has exact synonym: activated blood coagulation factor XIV activity
has exact synonym: autoprothrombin IIA activity
has OBO namespace: molecular_function
has related synonym: GSAPC
has related synonym: activated protein C
has related synonym: autoprothrombin II-A
has related synonym: blood-coagulation factor XIVa
has related synonym: protein Ca
id: GO:0003808
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

thrombin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.5
has db xref: MetaCyc:3.4.21.5-RXN
has exact synonym: fibrinogenase activity
has exact synonym: thrombase activity
has OBO namespace: molecular_function
has related synonym: E thrombin
has related synonym: activated blood-coagulation factor II
has related synonym: beta-thrombin
has related synonym: blood-coagulation factor IIa
has related synonym: factor IIa
has related synonym: gamma-thrombin
has related synonym: thrombin-C
has related synonym: thrombofort
has related synonym: topical
has related synonym: tropostasin
id: GO:0003809
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

protein-glutamine gamma-glutamyltransferase activity
IAO_0000115: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
has db xref: EC:2.3.2.13
has db xref: MetaCyc:2.3.2.13-RXN
has db xref: RESID:AA0124
has db xref: Reactome:REACT_101525
has db xref: Reactome:REACT_112106
has db xref: Reactome:REACT_112367
has db xref: Reactome:REACT_112902
has db xref: Reactome:REACT_1852
has db xref: Reactome:REACT_37344
has db xref: Reactome:REACT_82525
has db xref: Reactome:REACT_82887
has db xref: Reactome:REACT_89774
has db xref: Reactome:REACT_97354
has db xref: Reactome:REACT_98243
has exact synonym: R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
has exact synonym: TGase activity
has exact synonym: fibrinoligase activity
has exact synonym: glutaminylpeptide gamma-glutamyltransferase activity
has exact synonym: protein-glutamine:amine gamma-glutamyltransferase
has exact synonym: transglutaminase activity
has narrow synonym: tissue transglutaminase
has OBO namespace: molecular_function
has related synonym: factor XIIIa
has related synonym: fibrin stabilizing factor
has related synonym: polyamine transglutaminase activity
id: GO:0003810
in subset: gosubset prok
type: Class
subclass of: GO_0016755

complement activity
IAO_0000115: OBSOLETE. Any of a set of activities involved in the complement cascade.
consider: GO:0006956
has OBO namespace: molecular_function
id: GO:0003811
type: Class
comment: This term was made obsolete because it refers to involvement in a biological process.
deprecated: true

alternative-complement-pathway C3/C5 convertase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.
IAO_0100001: GO:0004252
has broad synonym: C3 convertase activity
has broad synonym: C5 convertase activity
has db xref: EC:3.4.21.47
has db xref: MetaCyc:3.4.21.47-RXN
has exact synonym: C3b,Bb,CVF,Bb,C5 convertase activity
has exact synonym: alternative complement pathway C3(C5) convertase activity
has exact synonym: complement C 3(C 5) convertase (amplification)
has exact synonym: complement component C3/C5 convertase (alternative) activity
has exact synonym: complement factor B activity
has exact synonym: proenzyme factor B
has exact synonym: properdin factor B activity
has narrow synonym: cobra venom factor-dependent C3 convertase
has OBO namespace: molecular_function
has related synonym: (C3b)n,Bb
has related synonym: (CVF)-dependent glycine-rich-beta-glucoprotein
has related synonym: C3 proactivator
has related synonym: CVF,Bb
has related synonym: glycine-rich beta-glycoprotein
has related synonym: heat-labile factor
id: GO:0003812
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

classical-complement-pathway C3/C5 convertase activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.
IAO_0100001: GO:0004252
has broad synonym: C3 convertase activity
has broad synonym: C5 convertase activity
has broad synonym: complement C2 activity
has db xref: EC:3.4.21.43
has db xref: MetaCyc:3.4.21.43-RXN
has exact synonym: complement C3 convertase activity
has OBO namespace: molecular_function
has related synonym: C42
has related synonym: C423
has related synonym: C4b,2a
has related synonym: C4b,2a,3b
has related synonym: complement C42
id: GO:0003813
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

complement component C1r activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.41
has db xref: MetaCyc:3.4.21.41-RXN
has exact synonym: C1r esterase activity
has OBO namespace: molecular_function
has related synonym: activated complement C1r
has related synonym: complement subcomponent C1r
id: GO:0003815
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

complement component C1s activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.42
has db xref: MetaCyc:3.4.21.42-RXN
has exact synonym: C1 esterase activity
has exact synonym: C1s esterase activity
has OBO namespace: molecular_function
has related synonym: activated complement C1s
has related synonym: complement C1s
has related synonym: complement subcomponent C1s
id: GO:0003816
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

complement factor D activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.46
has db xref: MetaCyc:3.4.21.46-RXN
has exact synonym: C3 convertase activator activity
has exact synonym: C3 proactivator convertase activity
has exact synonym: adipsin
has exact synonym: properdin factor D esterase activity
has OBO namespace: molecular_function
has related synonym: factor D
has related synonym: factor D (complement)
id: GO:0003817
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

complement factor I activity
IAO_0000115: OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.45
has db xref: MetaCyc:3.4.21.45-RXN
has exact synonym: C3b/C4b inactivator activity
has exact synonym: complement component C3b inactivator activity
has narrow synonym: C3b inactivator activity
has OBO namespace: molecular_function
has related synonym: C3bINA
has related synonym: complement C3b inactivator
has related synonym: complement C3b/C4b inactivator
has related synonym: complement C4b inactivator
has related synonym: complement C4bi
has related synonym: conglutinogen-activating factor C
has related synonym: factor I
id: GO:0003818
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

major histocompatibility complex antigen
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has exact synonym: MHC protein
has OBO namespace: molecular_function
id: GO:0003819
type: Class
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
deprecated: true

class I major histocompatibility complex antigen
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0042612
has OBO namespace: molecular_function
id: GO:0003820
type: Class
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
deprecated: true

class II major histocompatibility complex antigen
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0042613
has OBO namespace: molecular_function
id: GO:0003821
type: Class
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
deprecated: true

MHC-interacting protein
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0003822
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

antigen binding
IAO_0000115: Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
has OBO namespace: molecular_function
has related synonym: B cell receptor activity
has related synonym: antibody
has related synonym: immunoglobulin
has related synonym: opsonin activity
id: GO:0003823
in subset: goslim pir
type: Class
subclass of: GO_0005488

catalytic activity
IAO_0000115: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
has db xref: Wikipedia:Enzyme
has exact synonym: enzyme activity
has OBO namespace: molecular_function
id: GO:0003824
in subset: goslim pir
in subset: goslim plant
in subset: gosubset prok
type: Class
subclass of: molecular_function

alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.
has db xref: EC:2.4.1.15
has db xref: MetaCyc:TREHALOSE6PSYN-RXN
has db xref: RHEA:18892
has db xref: Reactome:REACT_27138
has exact synonym: UDP-glucose-glucose-phosphate glucosyltransferase activity
has exact synonym: UDP-glucose-glucosephosphate glucosyltransferase activity
has exact synonym: UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
has exact synonym: UDPglucose-glucose-phosphate glucosyltransferase activity
has exact synonym: UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
has exact synonym: alpha,alpha-trehalose phosphate synthase (UDP-forming)
has exact synonym: phosphotrehalose-uridine diphosphate transglucosylase activity
has exact synonym: transglucosylase activity
has exact synonym: trehalose 6-phosphate synthase activity
has exact synonym: trehalose 6-phosphate synthetase activity
has exact synonym: trehalose phosphate synthase activity
has exact synonym: trehalose phosphate synthetase activity
has exact synonym: trehalose phosphate-uridine diphosphate glucosyltransferase activity
has exact synonym: trehalose-P synthetase activity
has exact synonym: trehalose-phosphate synthase activity
has exact synonym: trehalose-phosphate synthetase activity
has exact synonym: trehalosephosphate-UDP glucosyl transferase activity
has exact synonym: trehalosephosphate-UDP glucosyltransferase activity
has exact synonym: uridine diphosphoglucose phosphate glucosyltransferase activity
has OBO namespace: molecular_function
id: GO:0003825
in subset: gosubset prok
type: Class
subclass of: GO_0035251

alpha-ketoacid dehydrogenase activity
IAO_0000115: Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid.
has db xref: Reactome:REACT_101696
has db xref: Reactome:REACT_101855
has db xref: Reactome:REACT_102398
has db xref: Reactome:REACT_109062
has db xref: Reactome:REACT_113399
has db xref: Reactome:REACT_1813
has db xref: Reactome:REACT_30155
has db xref: Reactome:REACT_30632
has db xref: Reactome:REACT_30883
has db xref: Reactome:REACT_33771
has db xref: Reactome:REACT_34024
has db xref: Reactome:REACT_34280
has db xref: Reactome:REACT_81262
has db xref: Reactome:REACT_86541
has db xref: Reactome:REACT_88849
has db xref: Reactome:REACT_92556
has db xref: Reactome:REACT_95085
has db xref: Reactome:REACT_96212
has OBO namespace: molecular_function
id: GO:0003826
in subset: gosubset prok
type: Class
subclass of: GO_0016491

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP.
has db xref: EC:2.4.1.101
has db xref: KEGG:R05983
has db xref: MetaCyc:2.4.1.101-RXN
has db xref: RHEA:11459
has db xref: Reactome:REACT_25236
has exact synonym: GNTI activity
has exact synonym: N-acetylglucosaminyltransferase I activity
has exact synonym: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
has exact synonym: UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity
has exact synonym: UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity
has exact synonym: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has OBO namespace: molecular_function
has related synonym: GnTI
id: GO:0003827
type: Class
subclass of: GO_0008375

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
has db xref: EC:2.4.99.8
has db xref: MetaCyc:2.4.99.8-RXN
has db xref: RHEA:19316
has db xref: Reactome:REACT_103372
has db xref: Reactome:REACT_103428
has db xref: Reactome:REACT_104790
has db xref: Reactome:REACT_105388
has db xref: Reactome:REACT_110734
has db xref: Reactome:REACT_18324
has db xref: Reactome:REACT_25115
has db xref: Reactome:REACT_32138
has db xref: Reactome:REACT_34632
has db xref: Reactome:REACT_85065
has db xref: Reactome:REACT_86310
has exact synonym: CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity
has exact synonym: CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity
has exact synonym: CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity
has exact synonym: GD3 synthase activity
has exact synonym: alpha-2,8-sialyltransferase activity
has exact synonym: alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
has exact synonym: ganglioside GD3 synthase activity
has exact synonym: ganglioside GD3 synthetase sialyltransferase activity
has OBO namespace: molecular_function
has related synonym: SAT-2
has related synonym: cytidine monophosphoacetylneuraminate-ganglioside GM3
id: GO:0003828
type: Class
subclass of: GO_0008373

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.
has db xref: EC:2.4.1.102
has db xref: MetaCyc:2.4.1.102-RXN
has db xref: RHEA:18708
has db xref: Reactome:REACT_115554
has db xref: Reactome:REACT_115905
has exact synonym: O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
has exact synonym: UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: beta(6)-N-acetylglucosaminyltransferase activity
has exact synonym: beta6-N-acetylglucosaminyltransferase activity
has exact synonym: core 2 acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity
has OBO namespace: molecular_function
has related synonym: core 6-beta-GlcNAc-transferase A
id: GO:0003829
type: Class
subclass of: GO_0008375

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.
has db xref: EC:2.4.1.144
has db xref: MetaCyc:2.4.1.144-RXN
has db xref: Reactome:REACT_25005
has exact synonym: GnTIII activity
has exact synonym: N-acetylglucosaminyltransferase III activity
has exact synonym: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity
has exact synonym: UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
has exact synonym: beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity
has OBO namespace: molecular_function
has related synonym: uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
id: GO:0003830
in subset: gosubset prok
type: Class
subclass of: GO_0008375

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.
has db xref: EC:2.4.1.38
has db xref: MetaCyc:2.4.1.38-RXN
has db xref: RHEA:22935
has db xref: Reactome:REACT_25178
has exact synonym: UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity
has exact synonym: UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity
has exact synonym: UDP-galactose--glycoprotein galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
has exact synonym: UDPgalactose-glycoprotein galactosyltransferase activity
has exact synonym: UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
has exact synonym: beta-N-acetyl-beta-(1,4)-galactosyltransferase activity
has exact synonym: beta-N-acetyl-beta-1,4-galactosyltransferase activity
has exact synonym: glycoprotein 4-beta-galactosyl-transferase activity
has exact synonym: glycoprotein 4-beta-galactosyltransferase activity
has exact synonym: glycoprotein beta-galactosyltransferase activity
has exact synonym: uridine diphosphogalactose-glycoprotein galactosyltransferase activity
has narrow synonym: thyroid galactosyltransferase activity
has narrow synonym: thyroid glycoprotein beta-galactosyltransferase
has OBO namespace: molecular_function
has related synonym: GalT activity
id: GO:0003831
type: Class
subclass of: GO_0035250

beta-alanyl-dopamine hydrolase activity
IAO_0000115: Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine.
has exact synonym: N-beta-alanyl-dopamine hydrolase activity
has exact synonym: NBAD hydrolase activity
has OBO namespace: molecular_function
id: GO:0003832
type: Class
subclass of: GO_0016787

beta-alanyl-dopamine synthase activity
IAO_0000115: Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine).
has exact synonym: N-beta-alanyl dopamine synthetase activity
has exact synonym: NBAD transferase activity
has OBO namespace: molecular_function
id: GO:0003833
type: Class
subclass of: GO_0016874

beta-carotene 15,15'-monooxygenase activity
IAO_0000115: Catalysis of the reaction: beta-carotene + O(2) = 2 retinal.
has db xref: EC:1.14.99.36
has db xref: KEGG:R00032
has db xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN
has db xref: RHEA:10407
has db xref: Reactome:REACT_25117
has exact synonym: beta-carotene 15,15'-dioxygenase activity
has exact synonym: beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)
has exact synonym: carotene 15,15'-dioxygenase activity
has exact synonym: carotene dioxygenase activity
has OBO namespace: molecular_function
id: GO:0003834
type: Class
comment: Note that this function was formerly EC:1.13.11.21.
subclass of: GO_0016702

beta-galactoside alpha-2,6-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.
has db xref: EC:2.4.99.1
has db xref: MetaCyc:2.4.99.1-RXN
has db xref: RHEA:11839
has db xref: Reactome:REACT_115891
has db xref: Reactome:REACT_115991
has db xref: Reactome:REACT_24990
has exact synonym: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity
has exact synonym: CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity
has exact synonym: beta-galactosamide alpha-2,6-sialyltransferase activity
has OBO namespace: molecular_function
id: GO:0003835
type: Class
subclass of: GO_0008373

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.
has db xref: EC:2.4.99.4
has db xref: MetaCyc:2.4.99.4-RXN
has db xref: RHEA:21619
has db xref: Reactome:REACT_116038
has db xref: Reactome:REACT_25121
has exact synonym: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity
has exact synonym: CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity
has OBO namespace: molecular_function
id: GO:0003836
type: Class
subclass of: GO_0008373

beta-ureidopropionase activity
IAO_0000115: Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.
has db xref: EC:3.5.1.6
has db xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN
has db xref: RHEA:11187
has db xref: Reactome:REACT_101423
has db xref: Reactome:REACT_102071
has db xref: Reactome:REACT_102892
has db xref: Reactome:REACT_103635
has db xref: Reactome:REACT_103759
has db xref: Reactome:REACT_104624
has db xref: Reactome:REACT_104670
has db xref: Reactome:REACT_105623
has db xref: Reactome:REACT_108466
has db xref: Reactome:REACT_110755
has db xref: Reactome:REACT_112730
has db xref: Reactome:REACT_115012
has db xref: Reactome:REACT_2183
has db xref: Reactome:REACT_28778
has db xref: Reactome:REACT_29340
has db xref: Reactome:REACT_34440
has db xref: Reactome:REACT_79448
has db xref: Reactome:REACT_82451
has db xref: Reactome:REACT_84087
has db xref: Reactome:REACT_84098
has db xref: Reactome:REACT_84968
has db xref: Reactome:REACT_87205
has db xref: Reactome:REACT_87574
has db xref: Reactome:REACT_87832
has db xref: Reactome:REACT_902
has db xref: Reactome:REACT_90983
has db xref: Reactome:REACT_92584
has db xref: Reactome:REACT_96079
has db xref: Reactome:REACT_96886
has db xref: Reactome:REACT_98071
has db xref: Reactome:REACT_99446
has db xref: Reactome:REACT_99655
has exact synonym: N-carbamoyl-beta-alanine amidohydrolase activity
has OBO namespace: molecular_function
id: GO:0003837
in subset: gosubset prok
type: Class
subclass of: GO_0016811

sterol 24-C-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
has db xref: EC:2.1.1.41
has db xref: MetaCyc:RXN3O-178
has db xref: RHEA:21131
has exact synonym: 24-sterol C-methyltransferase activity
has exact synonym: S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity
has exact synonym: S-adenosyl-4-methionine:sterol delta24-methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity
has exact synonym: delta(24)-methyltransferase activity
has exact synonym: delta(24)-sterol C-methyltransferase activity
has exact synonym: delta(24)-sterol methyltransferase activity
has exact synonym: delta24-methyltransferase activity
has exact synonym: delta24-sterol methyltransferase activity
has narrow synonym: SMT1 activity
has narrow synonym: phytosterol methyltransferase activity
has narrow synonym: zymosterol-24-methyltransferase activity
has OBO namespace: molecular_function
id: GO:0003838
in subset: gosubset prok
type: Class
subclass of: GO_0008169
subclass of: GO_0008757

gamma-glutamylcyclotransferase activity
IAO_0000115: Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
has db xref: EC:2.3.2.4
has db xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
has db xref: Reactome:REACT_75867
has db xref: Reactome:REACT_75929
has exact synonym: (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)
has exact synonym: L-glutamic cyclase activity
has exact synonym: gamma-L-glutamylcyclotransferase activity
has exact synonym: gamma-glutamyl-amino acid cyclotransferase activity
has OBO namespace: molecular_function
id: GO:0003839
type: Class
subclass of: GO_0016755

gamma-glutamyltransferase activity
IAO_0000115: Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.
has db xref: EC:2.3.2.2
has db xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN
has db xref: RHEA:28810
has db xref: Reactome:REACT_105103
has db xref: Reactome:REACT_107509
has db xref: Reactome:REACT_108503
has db xref: Reactome:REACT_109920
has db xref: Reactome:REACT_114722
has db xref: Reactome:REACT_15356
has db xref: Reactome:REACT_28900
has db xref: Reactome:REACT_29202
has db xref: Reactome:REACT_75920
has db xref: Reactome:REACT_79594
has db xref: Reactome:REACT_80649
has db xref: Reactome:REACT_82062
has db xref: Reactome:REACT_85164
has db xref: Reactome:REACT_92059
has db xref: Reactome:REACT_97168
has db xref: Reactome:REACT_99498
has exact synonym: (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity
has exact synonym: L-gamma-glutamyl transpeptidase activity
has exact synonym: L-gamma-glutamyltransferase activity
has exact synonym: L-glutamyltransferase activity
has exact synonym: alpha-glutamyl transpeptidase activity
has exact synonym: gamma-glutamyl peptidyltransferase activity
has exact synonym: gamma-glutamyl transpeptidase activity
has exact synonym: glutamyl transpeptidase activity
has OBO namespace: molecular_function
has related synonym: gamma-GPT
has related synonym: gamma-GT
has related synonym: gamma-GTP
id: GO:0003840
in subset: gosubset prok
type: Class
subclass of: GO_0016755

1-acylglycerol-3-phosphate O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
has alternative id: GO:0004469
has db xref: EC:2.3.1.51
has db xref: MetaCyc:RXN-1623
has db xref: RHEA:19712
has db xref: Reactome:REACT_100569
has db xref: Reactome:REACT_101159
has db xref: Reactome:REACT_104719
has db xref: Reactome:REACT_108799
has db xref: Reactome:REACT_109082
has db xref: Reactome:REACT_113184
has db xref: Reactome:REACT_113260
has db xref: Reactome:REACT_115377
has db xref: Reactome:REACT_2042
has db xref: Reactome:REACT_30683
has db xref: Reactome:REACT_32891
has db xref: Reactome:REACT_79417
has db xref: Reactome:REACT_81957
has db xref: Reactome:REACT_84904
has db xref: Reactome:REACT_93954
has db xref: Reactome:REACT_93992
has db xref: Reactome:REACT_96723
has db xref: Reactome:REACT_97949
has db xref: Reactome:REACT_99430
has exact synonym: 1-acyl-sn-glycero-3-phosphate acyltransferase activity
has exact synonym: 1-acyl-sn-glycerol 3-phosphate acyltransferase activity
has exact synonym: 1-acyl-sn-glycerol-3-phosphate acyltransferase activity
has exact synonym: 1-acylglycero-3-phosphate acyltransferase activity
has exact synonym: 1-acylglycerolphosphate acyltransferase activity
has exact synonym: 1-acylglycerophosphate acyltransferase activity
has exact synonym: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity
has exact synonym: lysophosphatidate acyltransferase activity
has OBO namespace: molecular_function
has related synonym: lysophosphatidic acid-acyltransferase activity
id: GO:0003841
in subset: gosubset prok
type: Class
subclass of: GO_0016411

1-pyrroline-5-carboxylate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
has broad synonym: 1-pyrroline dehydrogenase
has db xref: EC:1.5.1.12
has db xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN
has db xref: RHEA:16420
has db xref: Reactome:REACT_101154
has db xref: Reactome:REACT_2180
has db xref: Reactome:REACT_28267
has db xref: Reactome:REACT_29350
has db xref: Reactome:REACT_30746
has db xref: Reactome:REACT_32976
has db xref: Reactome:REACT_33427
has db xref: Reactome:REACT_77246
has db xref: Reactome:REACT_78368
has db xref: Reactome:REACT_79652
has db xref: Reactome:REACT_82290
has db xref: Reactome:REACT_83335
has db xref: Reactome:REACT_84624
has db xref: Reactome:REACT_88645
has db xref: Reactome:REACT_91287
has db xref: Reactome:REACT_94154
has db xref: Reactome:REACT_97859
has exact synonym: 1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity
has exact synonym: L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity
has exact synonym: delta1-pyrroline-5-carboxylate dehydrogenase activity
has exact synonym: pyrroline-5-carboxylate dehydrogenase activity
has exact synonym: pyrroline-5-carboxylic acid dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0003842
in subset: gosubset prok
type: Class
subclass of: GO_0016646

1,3-beta-D-glucan synthase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
has alternative id: GO:0009981
has db xref: EC:2.4.1.34
has db xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN
has exact synonym: (1,3)-beta-glucan (callose) synthase activity
has exact synonym: 1,3-beta-D-glucan synthetase activity
has exact synonym: 1,3-beta-D-glucan-UDP glucosyltransferase activity
has exact synonym: 1,3-beta-glucan synthase activity
has exact synonym: 1,3-beta-glucan-uridine diphosphoglucosyltransferase activity
has exact synonym: UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity
has exact synonym: UDP-glucose-1,3-beta-glucan glucosyltransferase activity
has exact synonym: UDP-glucose-beta-glucan glucosyltransferase activity
has exact synonym: UDP-glucose:(1,3)beta-glucan synthase activity
has exact synonym: UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
has exact synonym: UDPglucose-1,3-beta-D-glucan glucosyltransferase activity
has exact synonym: UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
has exact synonym: beta-1,3-glucan synthase activity
has exact synonym: beta-1,3-glucan synthetase activity
has exact synonym: callose synthase activity
has exact synonym: callose synthetase activity
has exact synonym: uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity
has OBO namespace: molecular_function
has related synonym: GS-II
has related synonym: paramylon synthetase
id: GO:0003843
type: Class
subclass of: GO_0035251

1,4-alpha-glucan branching enzyme activity
IAO_0000115: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
has db xref: EC:2.4.1.18
has db xref: MetaCyc:GLYCOGEN-BRANCH-RXN
has db xref: Reactome:REACT_105148
has db xref: Reactome:REACT_106694
has db xref: Reactome:REACT_107726
has db xref: Reactome:REACT_115406
has db xref: Reactome:REACT_1560
has db xref: Reactome:REACT_30904
has db xref: Reactome:REACT_32069
has db xref: Reactome:REACT_34100
has db xref: Reactome:REACT_86636
has db xref: Reactome:REACT_89477
has db xref: Reactome:REACT_89641
has db xref: Reactome:REACT_94260
has db xref: Reactome:REACT_94674
has db xref: Reactome:REACT_96621
has exact synonym: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity
has exact synonym: 1,4-glucan-6-(1,4-glucano)-transferase activity
has exact synonym: alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity
has exact synonym: alpha-glucan-branching glycosyltransferase activity
has exact synonym: amylo-(1,4 to 1,6)transglucosidase activity
has exact synonym: amylo-(1,4->1,6)-transglycosylase activity
has exact synonym: amylose isomerase activity
has exact synonym: branching glycosyltransferase activity
has exact synonym: glucosan transglycosylase activity
has exact synonym: glycogen branching enzyme activity
has OBO namespace: molecular_function
has related synonym: Q-enzyme
has related synonym: branching enzyme activity
has related synonym: enzymatic branching factor
has related synonym: enzyme Q
has related synonym: plant branching enzyme
has related synonym: starch branching enzyme
id: GO:0003844
in subset: gosubset prok
type: Class
subclass of: GO_0016758

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
IAO_0000115: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+).
has broad synonym: beta-hydroxysteroid dehydrogenase
has db xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
has db xref: Reactome:REACT_10043
has db xref: Reactome:REACT_102267
has db xref: Reactome:REACT_114165
has db xref: Reactome:REACT_31438
has db xref: Reactome:REACT_32859
has db xref: Reactome:REACT_82916
has db xref: Reactome:REACT_84167
has db xref: Reactome:REACT_84288
has db xref: Reactome:REACT_86323
has db xref: Reactome:REACT_86610
has db xref: Reactome:REACT_93487
has db xref: Reactome:REACT_95677
has db xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
has exact synonym: 11beta-hydroxy steroid dehydrogenase
has exact synonym: 11beta-hydroxysteroid dehydrogenase
has exact synonym: dehydrogenase, 11beta-hydroxy steroid
has OBO namespace: molecular_function
has related synonym: corticosteroid 11-reductase
has related synonym: corticosteroid 11beta-dehydrogenase
id: GO:0003845
in subset: gosubset prok
type: Class
subclass of: GO_0033764

2-acylglycerol O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
has db xref: EC:2.3.1.22
has db xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
has db xref: RHEA:16744
has exact synonym: acyl coenzyme A-monoglyceride acyltransferase activity
has exact synonym: acyl-CoA:2-acylglycerol O-acyltransferase activity
has exact synonym: acylglycerol palmitoyltransferase activity
has exact synonym: monoacylglycerol acyltransferase activity
has exact synonym: monoglyceride acyltransferase activity
has OBO namespace: molecular_function
id: GO:0003846
type: Class
subclass of: GO_0016411

1-alkyl-2-acetylglycerophosphocholine esterase activity
IAO_0000115: Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
has db xref: EC:3.1.1.47
has db xref: MetaCyc:3.1.1.47-RXN
has db xref: RHEA:17780
has exact synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity
has exact synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity
has exact synonym: 2-acetyl-1-alkylglycerophosphocholine esterase activity
has exact synonym: alkylacetyl-GPC:acetylhydrolase activity
has OBO namespace: molecular_function
has related synonym: LDL-PLA(2) activity
has related synonym: LDL-PLA2
has related synonym: LDL-associated phospholipase A(2) activity
has related synonym: LDL-associated phospholipase A2
has related synonym: PAF 2-acylhydrolase activity
has related synonym: PAF acetylhydrolase activity
has related synonym: platelet-activating factor acetylhydrolase activity
id: GO:0003847
in subset: gosubset prok
type: Class
subclass of: GO_0052689

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
has db xref: EC:2.7.6.3
has db xref: KEGG:R03503
has db xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
has db xref: RHEA:11415
has exact synonym: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
has exact synonym: 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
has exact synonym: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
has exact synonym: 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
has exact synonym: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
has exact synonym: 7,8-dihydroxymethylpterin-pyrophosphokinase activity
has exact synonym: ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
has exact synonym: H2-pteridine-CH2OH pyrophosphokinase activity
has exact synonym: hydroxymethyldihydropteridine pyrophosphokinase activity
has OBO namespace: molecular_function
has related synonym: HPPK
id: GO:0003848
in subset: gosubset prok
type: Class
subclass of: GO_0016778

3-deoxy-7-phosphoheptulonate synthase activity
IAO_0000115: Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.
has db xref: EC:2.5.1.54
has db xref: KEGG:R01826
has db xref: MetaCyc:DAHPSYN-RXN
has db xref: RHEA:14720
has db xref: Reactome:REACT_27267
has exact synonym: 2-dehydro-3-deoxy-phosphoheptonate aldolase activity
has exact synonym: 2-dehydro-3-deoxyphosphoheptonate aldolase activity
has exact synonym: 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity
has exact synonym: 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity
has exact synonym: 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity
has exact synonym: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity
has exact synonym: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
has exact synonym: 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
has exact synonym: D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity
has exact synonym: DAH7-P synthase activity
has exact synonym: DAHP synthase activity
has exact synonym: DHAP synthase activity
has exact synonym: KDPH synthase activity
has exact synonym: KDPH synthetase activity
has exact synonym: deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity
has exact synonym: phospho-2-dehydro-3-deoxyheptonate aldolase activity
has exact synonym: phospho-2-keto-3-deoxyheptanoate aldolase activity
has exact synonym: phospho-2-keto-3-deoxyheptonate aldolase activity
has exact synonym: phospho-2-keto-3-deoxyheptonic aldolase activity
has exact synonym: phospho-2-oxo-3-deoxyheptonate aldolase activity
has exact synonym: phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
has OBO namespace: molecular_function
has related synonym: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
has related synonym: D-erythrose-4-phosphate-lyase activity
has related synonym: DS-Co activity
has related synonym: DS-Mn activity
id: GO:0003849
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.2.15.
subclass of: GO_0016765

2-deoxyglucose-6-phosphatase activity
IAO_0000115: Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
has db xref: EC:3.1.3.68
has db xref: KEGG:R02587
has db xref: MetaCyc:3.1.3.68-RXN
has db xref: RHEA:22239
has exact synonym: 2-deoxy-D-glucose-6-phosphate phosphohydrolase activity
has exact synonym: 2-deoxyglucose-6-phosphate phosphatase activity
has OBO namespace: molecular_function
id: GO:0003850
type: Class
subclass of: GO_0050308

2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.
has db xref: EC:2.4.1.45
has db xref: MetaCyc:2.4.1.45-RXN
has db xref: RHEA:10859
has exact synonym: UDP-galactose-ceramide galactosyltransferase activity
has exact synonym: UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
has exact synonym: UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity
has exact synonym: UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
has exact synonym: UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity
has exact synonym: UDPgalactose:ceramide galactosyltransferase activity
has exact synonym: cerebroside synthase activity
has exact synonym: uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity
has OBO namespace: molecular_function
id: GO:0003851
type: Class
subclass of: GO_0035250

2-isopropylmalate synthase activity
IAO_0000115: Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
has db xref: EC:2.3.3.13
has db xref: KEGG:R01213
has db xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN
has db xref: RHEA:21527
has exact synonym: 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
has exact synonym: acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has exact synonym: alpha-IPM synthetase activity
has exact synonym: alpha-isopropylmalate synthase activity
has exact synonym: alpha-isopropylmalate synthetase activity
has exact synonym: alpha-isopropylmalic synthetase activity
has exact synonym: isopropylmalate synthase activity
has exact synonym: isopropylmalate synthetase activity
has OBO namespace: molecular_function
id: GO:0003852
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.3.12.
subclass of: GO_0046912

2-methylacyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor.
has db xref: EC:1.3.99.12
has db xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN
has db xref: RHEA:13264
has exact synonym: 2-methyl branched chain acyl-CoA dehydrogenase activity
has exact synonym: 2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity
has exact synonym: 2-methylbutanoyl-CoA:acceptor oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: branched-chain acyl-CoA dehydrogenase activity
id: GO:0003853
type: Class
subclass of: acyl-CoA dehydrogenase activity

3-beta-hydroxy-delta5-steroid dehydrogenase activity
IAO_0000115: Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+).
has broad synonym: 3beta-hydroxy-delta5-C27-steroid oxidoreductase
has broad synonym: progesterone reductase activity
has db xref: EC:1.1.1.145
has db xref: MetaCyc:1.1.1.145-RXN
has db xref: Reactome:REACT_10031
has db xref: Reactome:REACT_10067
has db xref: Reactome:REACT_100839
has db xref: Reactome:REACT_10090
has db xref: Reactome:REACT_10115
has db xref: Reactome:REACT_101983
has db xref: Reactome:REACT_103390
has db xref: Reactome:REACT_103657
has db xref: Reactome:REACT_103990
has db xref: Reactome:REACT_104422
has db xref: Reactome:REACT_104615
has db xref: Reactome:REACT_105565
has db xref: Reactome:REACT_106120
has db xref: Reactome:REACT_106214
has db xref: Reactome:REACT_106644
has db xref: Reactome:REACT_108035
has db xref: Reactome:REACT_108087
has db xref: Reactome:REACT_108432
has db xref: Reactome:REACT_109510
has db xref: Reactome:REACT_111989
has db xref: Reactome:REACT_112248
has db xref: Reactome:REACT_113096
has db xref: Reactome:REACT_113257
has db xref: Reactome:REACT_113772
has db xref: Reactome:REACT_114424
has db xref: Reactome:REACT_114777
has db xref: Reactome:REACT_114921
has db xref: Reactome:REACT_115275
has db xref: Reactome:REACT_115303
has db xref: Reactome:REACT_28427
has db xref: Reactome:REACT_28467
has db xref: Reactome:REACT_29450
has db xref: Reactome:REACT_30525
has db xref: Reactome:REACT_30795
has db xref: Reactome:REACT_30899
has db xref: Reactome:REACT_32283
has db xref: Reactome:REACT_32783
has db xref: Reactome:REACT_32924
has db xref: Reactome:REACT_33199
has db xref: Reactome:REACT_33352
has db xref: Reactome:REACT_34556
has db xref: Reactome:REACT_77900
has db xref: Reactome:REACT_78893
has db xref: Reactome:REACT_79104
has db xref: Reactome:REACT_79525
has db xref: Reactome:REACT_79553
has db xref: Reactome:REACT_80359
has db xref: Reactome:REACT_80746
has db xref: Reactome:REACT_81646
has db xref: Reactome:REACT_82293
has db xref: Reactome:REACT_82688
has db xref: Reactome:REACT_84251
has db xref: Reactome:REACT_85738
has db xref: Reactome:REACT_86717
has db xref: Reactome:REACT_87612
has db xref: Reactome:REACT_88118
has db xref: Reactome:REACT_88292
has db xref: Reactome:REACT_88643
has db xref: Reactome:REACT_91120
has db xref: Reactome:REACT_93787
has db xref: Reactome:REACT_94450
has db xref: Reactome:REACT_96507
has db xref: Reactome:REACT_99573
has db xref: Reactome:REACT_99689
has db xref: Reactome:REACT_9989
has exact synonym: 3-beta-hydroxy-5-ene steroid dehydrogenase activity
has exact synonym: 3-beta-hydroxy-D5-steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy steroid dehydrogenase/isomerase activity
has exact synonym: 3beta-hydroxy-5-ene steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy-5-ene-steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy-5-ene-steroid oxidoreductase activity
has exact synonym: 3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity
has exact synonym: 3beta-hydroxy-delta5-steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity
has exact synonym: 5-ene-3-beta-hydroxysteroid dehydrogenase activity

3-dehydroquinate dehydratase activity
IAO_0000115: Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
has db xref: EC:4.2.1.10
has db xref: KEGG:R03084
has db xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN
has db xref: RHEA:21099
has db xref: Reactome:REACT_27221
has exact synonym: 3-dehydroquinase activity
has exact synonym: 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
has exact synonym: 3-dehydroquinate hydro-lyase activity
has exact synonym: 3-dehydroquinate hydrolase activity
has exact synonym: 5-dehydroquinase activity
has exact synonym: 5-dehydroquinate dehydratase activity
has exact synonym: 5-dehydroquinate hydro-lyase activity
has exact synonym: DHQase
has exact synonym: dehydroquinase activity
has exact synonym: dehydroquinate dehydratase activity
has OBO namespace: molecular_function
id: GO:0003855
in subset: gosubset prok
type: Class
subclass of: GO_0016836

3-dehydroquinate synthase activity
IAO_0000115: Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.
has db xref: EC:4.2.3.4
has db xref: KEGG:R03083
has db xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN
has db xref: RHEA:21971
has db xref: Reactome:REACT_27251
has exact synonym: 3-dehydroquinate synthetase activity
has exact synonym: 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)
has exact synonym: 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)
has exact synonym: 3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)
has exact synonym: 5-dehydroquinate synthase activity
has exact synonym: 5-dehydroquinic acid synthetase activity
has exact synonym: DHQ synthase
has exact synonym: DHQS
has exact synonym: dehydroquinate synthase activity
has OBO namespace: molecular_function
id: GO:0003856
in subset: gosubset prok
type: Class
subclass of: GO_0016838

3-hydroxyacyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
has broad synonym: beta-ketoacyl-CoA reductase
has db xref: EC:1.1.1.35
has db xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN
has db xref: RHEA:22435
has db xref: Reactome:REACT_100238
has db xref: Reactome:REACT_100408
has db xref: Reactome:REACT_100617
has db xref: Reactome:REACT_10065
has db xref: Reactome:REACT_101468
has db xref: Reactome:REACT_101506
has db xref: Reactome:REACT_101519
has db xref: Reactome:REACT_101647
has db xref: Reactome:REACT_101913
has db xref: Reactome:REACT_101921
has db xref: Reactome:REACT_102671
has db xref: Reactome:REACT_102910
has db xref: Reactome:REACT_102920
has db xref: Reactome:REACT_103002
has db xref: Reactome:REACT_103054
has db xref: Reactome:REACT_103256
has db xref: Reactome:REACT_103362
has db xref: Reactome:REACT_103856
has db xref: Reactome:REACT_104004
has db xref: Reactome:REACT_104064
has db xref: Reactome:REACT_104792
has db xref: Reactome:REACT_105101
has db xref: Reactome:REACT_105286
has db xref: Reactome:REACT_105300
has db xref: Reactome:REACT_106598
has db xref: Reactome:REACT_106630
has db xref: Reactome:REACT_106706
has db xref: Reactome:REACT_106767
has db xref: Reactome:REACT_106920
has db xref: Reactome:REACT_106947
has db xref: Reactome:REACT_106969
has db xref: Reactome:REACT_106993
has db xref: Reactome:REACT_107615
has db xref: Reactome:REACT_107618
has db xref: Reactome:REACT_107700
has db xref: Reactome:REACT_107858
has db xref: Reactome:REACT_107953
has db xref: Reactome:REACT_107981
has db xref: Reactome:REACT_108093
has db xref: Reactome:REACT_108518
has db xref: Reactome:REACT_108521
has db xref: Reactome:REACT_109194
has db xref: Reactome:REACT_109636
has db xref: Reactome:REACT_109679
has db xref: Reactome:REACT_109823
has db xref: Reactome:REACT_109984
has db xref: Reactome:REACT_110388
has db xref: Reactome:REACT_110947
has db xref: Reactome:REACT_112490
has db xref: Reactome:REACT_113301
has db xref: Reactome:REACT_113705
has db xref: Reactome:REACT_115146
has db xref: Reactome:REACT_115227
has db xref: Reactome:REACT_16971
has db xref: Reactome:REACT_16976
has db xref: Reactome:REACT_1908
has db xref: Reactome:REACT_21320
has db xref: Reactome:REACT_2187
has db xref: Reactome:REACT_2195
has db xref: Reactome:REACT_2238
has db xref: Reactome:REACT_242
has db xref: Reactome:REACT_28171
has db xref: Reactome:REACT_28279
has db xref: Reactome:REACT_28310
has db xref: Reactome:REACT_28475
has db xref: Reactome:REACT_28502
has db xref: Reactome:REACT_28542
has db xref: Reactome:REACT_28734
has db xref: Reactome:REACT_28832
has db xref: Reactome:REACT_28849
has db xref: Reactome:REACT_29078
has db xref: Reactome:REACT_29670
has db xref: Reactome:REACT_29976
has db xref: Reactome:REACT_29995
has db xref: Reactome:REACT_29997

3-hydroxybutyrate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
has db xref: EC:1.1.1.30
has db xref: KEGG:R01361
has db xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
has db xref: RHEA:20524
has db xref: Reactome:REACT_100598
has db xref: Reactome:REACT_100701
has db xref: Reactome:REACT_101716
has db xref: Reactome:REACT_103885
has db xref: Reactome:REACT_104408
has db xref: Reactome:REACT_108608
has db xref: Reactome:REACT_110558
has db xref: Reactome:REACT_1493
has db xref: Reactome:REACT_31121
has db xref: Reactome:REACT_31745
has db xref: Reactome:REACT_32814
has db xref: Reactome:REACT_631
has db xref: Reactome:REACT_81074
has db xref: Reactome:REACT_84906
has db xref: Reactome:REACT_85059
has db xref: Reactome:REACT_87253
has db xref: Reactome:REACT_87733
has db xref: Reactome:REACT_89789
has db xref: Reactome:REACT_90360
has db xref: Reactome:REACT_91670
has db xref: Reactome:REACT_95508
has db xref: Reactome:REACT_97547
has exact synonym: D-beta-hydroxybutyrate dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0003858
in subset: gosubset prok
type: Class
subclass of: GO_0016616

3-hydroxybutyryl-CoA dehydratase activity
IAO_0000115: Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O.
has broad synonym: enoyl coenzyme A hydrase (D)
has db xref: EC:4.2.1.55
has db xref: KEGG:R03027
has db xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN
has db xref: RHEA:17852
has exact synonym: (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)
has exact synonym: (3R)-3-hydroxybutanoyl-CoA hydro-lyase activity
has exact synonym: D-3-hydroxybutyryl coenzyme A dehydratase activity
has exact synonym: D-3-hydroxybutyryl-CoA dehydratase activity
has exact synonym: crotonase activity
has OBO namespace: molecular_function
id: GO:0003859
in subset: gosubset prok
type: Class
subclass of: GO_0016836

3-hydroxyisobutyryl-CoA hydrolase activity
IAO_0000115: Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.
has db xref: EC:3.1.2.4
has db xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
has db xref: RHEA:20891
has db xref: Reactome:REACT_101449
has db xref: Reactome:REACT_102854
has db xref: Reactome:REACT_104494
has db xref: Reactome:REACT_106977
has db xref: Reactome:REACT_107222
has db xref: Reactome:REACT_111014
has db xref: Reactome:REACT_115031
has db xref: Reactome:REACT_29772
has db xref: Reactome:REACT_34277
has db xref: Reactome:REACT_77522
has db xref: Reactome:REACT_78256
has db xref: Reactome:REACT_83318
has db xref: Reactome:REACT_919
has db xref: Reactome:REACT_92394
has db xref: Reactome:REACT_93703
has db xref: Reactome:REACT_95071
has db xref: Reactome:REACT_96788
has db xref: Reactome:REACT_97387
has db xref: Reactome:REACT_99747
has exact synonym: 3-hydroxy-2-methylpropanoyl-CoA hydrolase activity
has exact synonym: 3-hydroxy-isobutyryl CoA hydrolase activity
has exact synonym: HIB CoA deacylase activity
has OBO namespace: molecular_function
id: GO:0003860
in subset: gosubset prok
type: Class
subclass of: GO_0016289

3-isopropylmalate dehydratase activity
IAO_0000115: Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O.
has db xref: EC:4.2.1.33
has db xref: MetaCyc:3-ISOPROPYLMALISOM-RXN
has exact synonym: (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
has exact synonym: (2R,3S)-3-isopropylmalate hydro-lyase activity
has exact synonym: alpha-IPM isomerase activity
has exact synonym: alpha-isopropylmalate isomerase activity
has exact synonym: beta-isopropylmalate dehydratase activity
has exact synonym: isopropylmalate isomerase activity
has OBO namespace: molecular_function
id: GO:0003861
in subset: gosubset prok
type: Class
subclass of: GO_0016836

3-isopropylmalate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
has db xref: EC:1.1.1.85
has db xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN
has db xref: RHEA:25082
has exact synonym: (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity
has exact synonym: 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity
has exact synonym: IMDH activity
has exact synonym: beta-IPM dehydrogenase activity
has exact synonym: beta-isopropylmalate dehydrogenase activity
has exact synonym: threo-Ds-3-isopropylmalate dehydrogenase activity
has OBO namespace: molecular_function
has related synonym: IPMDH
has related synonym: beta-isopropylmalic enzyme
id: GO:0003862
in subset: gosubset prok
type: Class
subclass of: GO_0016616

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
IAO_0000115: Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.
has db xref: EC:1.2.4.4
has db xref: MetaCyc:1.2.4.4-RXN
has exact synonym: 2-oxoisocaproate dehydrogenase activity
has exact synonym: 2-oxoisovalerate (lipoate) dehydrogenase activity
has exact synonym: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
has exact synonym: 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
has exact synonym: 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
has exact synonym: alpha-keto-alpha-methylvalerate dehydrogenase activity
has exact synonym: alpha-ketoisocaproate dehydrogenase activity
has exact synonym: alpha-ketoisocaproic dehydrogenase activity
has exact synonym: alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
has exact synonym: alpha-ketoisovalerate dehydrogenase activity
has exact synonym: alpha-oxoisocaproate dehydrogenase activity
has exact synonym: dehydrogenase, 2-oxoisovalerate (lipoate) activity
has OBO namespace: molecular_function
has related synonym: BCKDH activity
has related synonym: BCOAD activity
has related synonym: branched chain keto acid dehydrogenase activity
has related synonym: branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
has related synonym: branched-chain 2-keto acid dehydrogenase activity
has related synonym: branched-chain 2-oxo acid dehydrogenase activity
has related synonym: branched-chain alpha-keto acid dehydrogenase activity
has related synonym: branched-chain alpha-oxo acid dehydrogenase activity
has related synonym: branched-chain keto acid dehydrogenase activity
has related synonym: branched-chain ketoacid dehydrogenase activity
has related synonym: dehydrogenase, branched chain alpha-keto acid activity
id: GO:0003863
in subset: gosubset prok
type: Class
subclass of: GO_0016624

3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.
has db xref: EC:2.1.2.11
has db xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
has db xref: RHEA:11827
has exact synonym: 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity
has exact synonym: 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity
has exact synonym: alpha-ketoisovalerate hydroxymethyltransferase activity
has exact synonym: dehydropantoate hydroxymethyltransferase activity
has exact synonym: ketopantoate hydroxymethyltransferase activity
has exact synonym: oxopantoate hydroxymethyltransferase activity
has OBO namespace: molecular_function
id: GO:0003864
in subset: gosubset prok
type: Class
subclass of: GO_0016742

3-oxo-5-alpha-steroid 4-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.
has broad synonym: 3-oxosteroid delta4-dehydrogenase
has broad synonym: 5alpha-reductase
has broad synonym: delta4-3-oxosteroid-5alpha-reductase
has broad synonym: steroid 5 alpha reductase
has broad synonym: steroid 5-alpha-reductase activity
has broad synonym: steroid 5alpha-reductase
has broad synonym: testosterone 5alpha-reductase
has db xref: EC:1.3.99.5
has db xref: MetaCyc:1.3.99.5-RXN
has db xref: Reactome:REACT_22210
has exact synonym: 3-keto-delta4-steroid-5alpha-reductase activity
has exact synonym: 3-oxo-5alpha-steroid 4-dehydrogenase activity
has exact synonym: 3-oxo-5alpha-steroid delta4-dehydrogenase activity
has exact synonym: 3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity
has exact synonym: 3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity
has exact synonym: 4-ene-3-ketosteroid-5alpha-oxidoreductase activity
has exact synonym: delta4-3-keto steroid 5alpha-reductase activity
has exact synonym: delta4-3-ketosteroid5alpha-oxidoreductase activity
has exact synonym: delta4-3-oxo steroid reductase activity
has exact synonym: delta4-5alpha-dehydrogenase activity
has exact synonym: steroid delta4-5alpha-reductase activity
has OBO namespace: molecular_function
id: GO:0003865
type: Class
subclass of: GO_0033765

3-phosphoshikimate 1-carboxyvinyltransferase activity
IAO_0000115: Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate.
has db xref: EC:2.5.1.19
has db xref: KEGG:R03460
has db xref: MetaCyc:2.5.1.19-RXN
has db xref: RHEA:21259
has db xref: Reactome:REACT_27315
has exact synonym: 3-enol-pyruvoylshikimate-5-phosphate synthase activity
has exact synonym: 5-enolpyruvylshikimate-3-phosphate synthase activity
has exact synonym: EPSP synthase activity
has exact synonym: phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity
has OBO namespace: molecular_function
id: GO:0003866
in subset: gosubset prok
type: Class
subclass of: GO_0016765

4-aminobutyrate transaminase activity
IAO_0000115: Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
has db xref: EC:2.6.1.19
has db xref: MetaCyc:GABATRANSAM-RXN
has db xref: RHEA:23355
has db xref: Reactome:REACT_23980
has exact synonym: 4-aminobutanoate transaminase activity
has exact synonym: 4-aminobutyrate aminotransferase activity
has exact synonym: 4-aminobutyric acid aminotransferase activity
has exact synonym: GABA aminotransferase activity
has exact synonym: GABA transaminase activity
has exact synonym: GABA transferase activity
has exact synonym: aminobutyrate aminotransferase activity
has exact synonym: aminobutyrate transaminase activity
has exact synonym: gamma-amino-N-butyrate transaminase activity
has exact synonym: gamma-aminobutyrate aminotransaminase activity
has exact synonym: gamma-aminobutyrate transaminase activity
has exact synonym: gamma-aminobutyric acid aminotransferase activity
has exact synonym: gamma-aminobutyric acid transaminase activity
has exact synonym: gamma-aminobutyric transaminase activity
has exact synonym: glutamate-succinic semialdehyde transaminase activity
has OBO namespace: molecular_function
has related synonym: beta-alanine aminotransferase
has related synonym: beta-alanine--oxoglutarate aminotransferase activity
has related synonym: beta-alanine-oxoglutarate transaminase activity
id: GO:0003867
in subset: gosubset prok
type: Class
subclass of: GO_0008483

4-hydroxyphenylpyruvate dioxygenase activity
IAO_0000115: Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
has db xref: EC:1.13.11.27
has db xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN
has db xref: RHEA:16192
has db xref: Reactome:REACT_101650
has db xref: Reactome:REACT_1145
has db xref: Reactome:REACT_29808
has db xref: Reactome:REACT_33537
has db xref: Reactome:REACT_33740
has db xref: Reactome:REACT_77319
has db xref: Reactome:REACT_77991
has db xref: Reactome:REACT_81665
has db xref: Reactome:REACT_85018
has db xref: Reactome:REACT_86998
has db xref: Reactome:REACT_92448
has db xref: Reactome:REACT_93903
has db xref: Reactome:REACT_94777
has db xref: Reactome:REACT_95395
has db xref: Reactome:REACT_99639
has db xref: UM-BBD_reactionID:r0298
has exact synonym: 4-hydroxyphenylpyruvate hydroxylase activity
has exact synonym: 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)
has exact synonym: 4-hydroxyphenylpyruvic acid dioxygenase activity
has exact synonym: p-hydroxyphenylpyruvate dioxygenase activity
has exact synonym: p-hydroxyphenylpyruvate hydroxylase activity
has exact synonym: p-hydroxyphenylpyruvate oxidase activity
has exact synonym: p-hydroxyphenylpyruvic acid hydroxylase activity
has exact synonym: p-hydroxyphenylpyruvic hydroxylase activity
has exact synonym: p-hydroxyphenylpyruvic oxidase activity
has OBO namespace: molecular_function
id: GO:0003868
in subset: gosubset prok
type: Class
subclass of: GO_0016702

4-nitrophenylphosphatase activity
IAO_0000115: Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate.
has db xref: EC:3.1.3.41
has db xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN
has db xref: RHEA:21667
has exact synonym: 4-nitrophenylphosphate phosphohydrolase activity
has exact synonym: K-pNPPase activity
has exact synonym: NPPase activity
has exact synonym: PNPPase activity
has exact synonym: ecto-p-nitrophenyl phosphatase activity
has exact synonym: nitrophenyl phosphatase activity
has exact synonym: p-nitrophenylphosphatase activity
has exact synonym: p-nitrophenylphosphate phosphohydrolase activity
has exact synonym: para-nitrophenyl phosphatase activity
has OBO namespace: molecular_function
id: GO:0003869
in subset: gosubset prok
type: Class
subclass of: GO_0016791

5-aminolevulinate synthase activity
IAO_0000115: Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
has db xref: EC:2.3.1.37
has db xref: KEGG:R00830
has db xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
has db xref: RHEA:12924
has db xref: Reactome:REACT_100294
has db xref: Reactome:REACT_100365
has db xref: Reactome:REACT_101248
has db xref: Reactome:REACT_101495
has db xref: Reactome:REACT_105074
has db xref: Reactome:REACT_106523
has db xref: Reactome:REACT_107818
has db xref: Reactome:REACT_116003
has db xref: Reactome:REACT_33006
has db xref: Reactome:REACT_84625
has db xref: Reactome:REACT_86826
has db xref: Reactome:REACT_89048
has db xref: Reactome:REACT_9463
has db xref: Reactome:REACT_96967
has db xref: Reactome:REACT_97632
has db xref: Reactome:REACT_98622
has exact synonym: 5-aminolevulinate synthetase activity
has exact synonym: 5-aminolevulinic acid synthase activity
has exact synonym: 5-aminolevulinic acid synthetase activity
has exact synonym: ALA synthase activity
has exact synonym: ALA synthetase activity
has exact synonym: ALAS activity
has exact synonym: alpha-aminolevulinic acid synthase activity
has exact synonym: aminolevulinate synthase activity
has exact synonym: aminolevulinate synthetase activity
has exact synonym: aminolevulinic acid synthase activity
has exact synonym: aminolevulinic acid synthetase activity
has exact synonym: aminolevulinic synthetase activity
has exact synonym: delta-ALA synthetase activity
has exact synonym: delta-aminolevulinate synthase activity
has exact synonym: delta-aminolevulinate synthetase activity
has exact synonym: delta-aminolevulinic acid synthase activity
has exact synonym: delta-aminolevulinic acid synthetase activity
has exact synonym: delta-aminolevulinic synthetase activity
has exact synonym: succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
has OBO namespace: molecular_function
id: GO:0003870
in subset: gosubset prok
type: Class
subclass of: GO_0016749

5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
IAO_0000115: Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
has db xref: EC:2.1.1.14
has db xref: KEGG:R04405
has db xref: MetaCyc:HOMOCYSMET-RXN
has db xref: RHEA:21199
has exact synonym: 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity
has exact synonym: cobalamin-independent methionine synthase activity
has exact synonym: homocysteine methylase activity
has exact synonym: methionine synthase (cobalamin-independent) activity
has exact synonym: methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity
has exact synonym: methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity
has exact synonym: tetrahydropteroylglutamate-homocysteine transmethylase activity
has exact synonym: tetrahydropteroyltriglutamate methyltransferase activity
has OBO namespace: molecular_function
has related synonym: MetE
id: GO:0003871
in subset: gosubset prok
type: Class
subclass of: GO_0008172
subclass of: GO_0042085

6-phosphofructokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
has broad synonym: phosphohexokinase activity
has db xref: EC:2.7.1.11
has db xref: MetaCyc:6PFRUCTPHOS-RXN
has db xref: RHEA:16112
has db xref: Reactome:REACT_102109
has db xref: Reactome:REACT_106558
has db xref: Reactome:REACT_107208
has db xref: Reactome:REACT_109655
has db xref: Reactome:REACT_110932
has db xref: Reactome:REACT_112049
has db xref: Reactome:REACT_114580
has db xref: Reactome:REACT_115926
has db xref: Reactome:REACT_31439
has db xref: Reactome:REACT_32340
has db xref: Reactome:REACT_736
has db xref: Reactome:REACT_77055
has db xref: Reactome:REACT_79025
has db xref: Reactome:REACT_83230
has db xref: Reactome:REACT_84532
has db xref: Reactome:REACT_85052
has db xref: Reactome:REACT_88450
has db xref: Reactome:REACT_91497
has db xref: Reactome:REACT_91731
has db xref: Reactome:REACT_96419
has db xref: Reactome:REACT_97626
has exact synonym: 6-phosphofructokinase reduction
has exact synonym: 6-phosphofructose 1-kinase activity
has exact synonym: ATP-dependent phosphofructokinase activity
has exact synonym: ATP:D-fructose-6-phosphate 1-phosphotransferase activity
has exact synonym: D-fructose-6-phosphate 1-phosphotransferase activity
has exact synonym: fructose 6-phosphate kinase activity
has exact synonym: fructose 6-phosphokinase activity
has exact synonym: nucleotide triphosphate-dependent phosphofructokinase activity
has exact synonym: phospho-1,6-fructokinase activity
has exact synonym: phosphofructokinase (phosphorylating)
has exact synonym: phosphofructokinase I activity
has OBO namespace: molecular_function
has related synonym: PFK
id: GO:0003872
in subset: gosubset prok
type: Class
subclass of: GO_0008443

6-phosphofructo-2-kinase activity
IAO_0000115: Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
has db xref: EC:2.7.1.105
has db xref: KEGG:R02732
has db xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN
has db xref: RHEA:15656
has db xref: Reactome:REACT_104172
has db xref: Reactome:REACT_105291
has db xref: Reactome:REACT_107963
has db xref: Reactome:REACT_115709
has db xref: Reactome:REACT_28048
has db xref: Reactome:REACT_29034
has db xref: Reactome:REACT_291
has db xref: Reactome:REACT_29935
has db xref: Reactome:REACT_31693
has db xref: Reactome:REACT_33667
has db xref: Reactome:REACT_34412
has db xref: Reactome:REACT_38435
has db xref: Reactome:REACT_78095
has db xref: Reactome:REACT_86368
has db xref: Reactome:REACT_87540
has db xref: Reactome:REACT_88240
has db xref: Reactome:REACT_91876
has db xref: Reactome:REACT_98327
has exact synonym: 6-phosphofructo-2-kinase (phosphorylating)
has exact synonym: 6-phosphofructose 2-kinase activity
has exact synonym: ATP:D-fructose-6-phosphate 2-phosphotransferase activity
has exact synonym: ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity
has exact synonym: fructose 6-phosphate 2-kinase activity
has exact synonym: phosphofructokinase 2 activity
has OBO namespace: molecular_function
id: GO:0003873
type: Class
subclass of: GO_0008443

6-pyruvoyltetrahydropterin synthase activity
IAO_0000115: Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate.
has db xref: EC:4.2.3.12
has db xref: KEGG:R04286
has db xref: MetaCyc:4.2.3.12-RXN
has db xref: RHEA:22051
has db xref: Reactome:REACT_111082
has exact synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity
has exact synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
has exact synonym: 6-pyruvoyl tetrahydrobiopterin synthase activity
has exact synonym: PTPS activity
has OBO namespace: molecular_function
id: GO:0003874
in subset: gosubset prok
type: Class
subclass of: GO_0016838

ADP-ribosylarginine hydrolase activity
IAO_0000115: Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose.
has db xref: EC:3.2.2.19
has db xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN
has db xref: RHEA:20787
has exact synonym: ADP-ribose-L-arginine cleavage enzyme activity
has exact synonym: ADP-ribose-L-arginine cleaving enzyme activity
has exact synonym: ADPribosylarginine hydrolase activity
has exact synonym: N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has exact synonym: nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has exact synonym: omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has exact synonym: protein ADP-ribosylarginine hydrolase activity
has exact synonym: protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has OBO namespace: molecular_function
id: GO:0003875
in subset: gosubset prok
type: Class
subclass of: GO_0016799

AMP deaminase activity
IAO_0000115: Catalysis of the reaction: AMP + H2O = IMP + NH3.
has db xref: EC:3.5.4.6
has db xref: MetaCyc:AMP-DEAMINASE-RXN
has db xref: RHEA:14780
has db xref: Reactome:REACT_101530
has db xref: Reactome:REACT_104690
has db xref: Reactome:REACT_105150
has db xref: Reactome:REACT_109344
has db xref: Reactome:REACT_111015
has db xref: Reactome:REACT_64973
has db xref: Reactome:REACT_700
has db xref: Reactome:REACT_77256
has db xref: Reactome:REACT_79516
has db xref: Reactome:REACT_79653
has db xref: Reactome:REACT_81794
has db xref: Reactome:REACT_83409
has db xref: Reactome:REACT_87577
has db xref: Reactome:REACT_95231
has db xref: Reactome:REACT_98379
has db xref: Reactome:REACT_98734
has db xref: Reactome:REACT_99903
has exact synonym: 5-AMP deaminase activity
has exact synonym: 5-adenylate deaminase activity
has exact synonym: 5-adenylic acid deaminase activity
has exact synonym: AMP aminase activity
has exact synonym: AMP aminohydrolase activity
has exact synonym: adenosine 5-monophosphate deaminase activity
has exact synonym: adenosine 5-phosphate aminohydrolase activity
has exact synonym: adenosine monophosphate deaminase activity
has exact synonym: adenyl deaminase activity
has exact synonym: adenylate aminohydrolase activity
has exact synonym: adenylate deaminase activity
has exact synonym: adenylate deaminase reaction
has exact synonym: adenylate desaminase activity
has exact synonym: adenylic acid deaminase activity
has exact synonym: adenylic deaminase activity
has narrow synonym: myoadenylate deaminase activity
has OBO namespace: molecular_function
id: GO:0003876
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

ATP adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
has db xref: EC:2.7.7.53
has db xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN
has db xref: RHEA:16580
has exact synonym: ADP:ATP adenylyltransferase activity
has exact synonym: AP-4-A phosphorylase activity
has exact synonym: adenine triphosphate adenylyltransferase activity
has exact synonym: bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity
has exact synonym: diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity
has exact synonym: diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)
has exact synonym: diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity
has exact synonym: diadenosinetetraphosphate alpha-beta-phosphorylase activity
has exact synonym: diadenosinetetraphosphate alphabeta-phosphorylase activity
has exact synonym: dinucleoside oligophosphate alphabeta-phosphorylase activity
has OBO namespace: molecular_function
id: GO:0003877
in subset: gosubset prok
type: Class
subclass of: GO_0070566

ATP citrate synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA.
has alternative id: GO:0046913
has db xref: EC:2.3.3.8
has db xref: KEGG:R00352
has db xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN
has db xref: MetaCyc:PWY-5172
has db xref: RHEA:21163
has db xref: Reactome:REACT_103402
has db xref: Reactome:REACT_105575
has db xref: Reactome:REACT_1141
has db xref: Reactome:REACT_114344
has db xref: Reactome:REACT_114419
has db xref: Reactome:REACT_29907
has db xref: Reactome:REACT_31411
has db xref: Reactome:REACT_34626
has db xref: Reactome:REACT_34711
has db xref: Reactome:REACT_78048
has db xref: Reactome:REACT_78150
has db xref: Reactome:REACT_83858
has db xref: Reactome:REACT_86684
has db xref: Reactome:REACT_90155
has db xref: Reactome:REACT_92200
has db xref: Reactome:REACT_93895
has db xref: Reactome:REACT_99638
has exact synonym: ATP citrate (pro-S)-lyase activity
has exact synonym: ATP-citrate (pro-S)-lyase activity
has exact synonym: ATP-citrate (pro-S-)-lyase activity
has exact synonym: ATP-citric lyase activity
has exact synonym: ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity
has exact synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity
has exact synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
has exact synonym: adenosine triphosphate citrate lyase activity
has exact synonym: citrate-ATP lyase activity
has OBO namespace: molecular_function
has related synonym: ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)
has related synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
has related synonym: citrate cleavage enzyme activity
has related synonym: citric cleavage enzyme activity
id: GO:0003878
type: Class
comment: Note that this function was formerly EC:4.1.3.8.
subclass of: GO_0046912

ATP phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
has db xref: EC:2.4.2.17
has db xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN
has db xref: RHEA:18476
has exact synonym: 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity
has exact synonym: adenosine triphosphate phosphoribosyltransferase activity
has exact synonym: phosphoribosyl ATP synthetase activity
has exact synonym: phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity
has exact synonym: phosphoribosyl-ATP diphosphorylase activity
has exact synonym: phosphoribosyl-ATP pyrophosphorylase activity
has exact synonym: phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity
has exact synonym: phosphoribosyladenosine triphosphate pyrophosphorylase activity
has exact synonym: phosphoribosyladenosine triphosphate synthetase activity
has exact synonym: phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity
has OBO namespace: molecular_function
id: GO:0003879
in subset: gosubset prok
type: Class
subclass of: GO_0016763

protein C-terminal carboxyl O-methyltransferase activity
IAO_0000115: Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.
has db xref: EC:2.1.1.-
has exact synonym: C-terminal protein carboxyl methyltransferase activity
has OBO namespace: molecular_function
id: GO:0003880
in subset: gosubset prok
type: Class
subclass of: GO_0051998

CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
IAO_0000115: Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+).
has db xref: EC:2.7.8.11
has db xref: KEGG:R01802
has db xref: MetaCyc:2.7.8.11-RXN
has db xref: RHEA:11583
has exact synonym: CDP diglyceride-inositol phosphatidyltransferase activity
has exact synonym: CDP-DG:inositol transferase activity
has exact synonym: CDP-diacylglycerol--inositol phosphatidyltransferase activity
has exact synonym: CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity
has exact synonym: CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity
has exact synonym: CDP-diglyceride-inositol transferase activity
has exact synonym: CDP-diglyceride:inositol transferase activity
has exact synonym: CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity
has exact synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity
has exact synonym: cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity
has exact synonym: cytidine diphosphoglyceride-inositol phosphatidyltransferase activity
has exact synonym: cytidine diphosphoglyceride-inositol transferase activity
has exact synonym: phosphatidylinositol synthase activity
has OBO namespace: molecular_function
id: GO:0003881
in subset: gosubset prok
type: Class
subclass of: GO_0017169

CDP-diacylglycerol-serine O-phosphatidyltransferase activity
IAO_0000115: Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine.
has broad synonym: serine exchange enzyme
has db xref: EC:2.7.8.8
has db xref: MetaCyc:PHOSPHASERSYN-RXN
has db xref: RHEA:16916
has exact synonym: CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity
has exact synonym: CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity
has exact synonym: CDP-diglyceride-L-serine phosphatidyltransferase activity
has exact synonym: CDP-diglyceride:serine phosphatidyltransferase activity
has exact synonym: CDP-diglycerine-serine O-phosphatidyltransferase activity
has exact synonym: CDPdiacylglycerol-serine O-phosphatidyltransferase activity
has exact synonym: CDPdiglyceride-serine O-phosphatidyltransferase activity
has exact synonym: PS synthase activity
has exact synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity
has exact synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity
has exact synonym: cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity
has exact synonym: phosphatidylserine synthase activity
has exact synonym: phosphatidylserine synthetase activity
has OBO namespace: molecular_function
id: GO:0003882
in subset: gosubset prok
type: Class
subclass of: GO_0017169

CTP synthase activity
IAO_0000115: Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
has db xref: EC:6.3.4.2
has db xref: MetaCyc:CTPSYN-RXN
has db xref: RHEA:16600
has db xref: Reactome:REACT_101507
has db xref: Reactome:REACT_102614
has db xref: Reactome:REACT_102874
has db xref: Reactome:REACT_105827
has db xref: Reactome:REACT_108024
has db xref: Reactome:REACT_109286
has db xref: Reactome:REACT_109358
has db xref: Reactome:REACT_110148
has db xref: Reactome:REACT_21305
has db xref: Reactome:REACT_28893
has db xref: Reactome:REACT_29290
has db xref: Reactome:REACT_32806
has db xref: Reactome:REACT_33151
has db xref: Reactome:REACT_34398
has db xref: Reactome:REACT_574
has db xref: Reactome:REACT_77809
has db xref: Reactome:REACT_78348
has db xref: Reactome:REACT_79156
has db xref: Reactome:REACT_79789
has db xref: Reactome:REACT_81861
has db xref: Reactome:REACT_82397
has db xref: Reactome:REACT_83666
has db xref: Reactome:REACT_83762
has db xref: Reactome:REACT_85039
has db xref: Reactome:REACT_85189
has db xref: Reactome:REACT_89739
has db xref: Reactome:REACT_89978
has db xref: Reactome:REACT_91233
has db xref: Reactome:REACT_93144
has db xref: Reactome:REACT_93220
has db xref: Reactome:REACT_96180
has db xref: Reactome:REACT_96817
has db xref: Reactome:REACT_98673
has db xref: Reactome:REACT_98846
has db xref: Reactome:REACT_99502
has exact synonym: CTP synthetase activity
has exact synonym: UTP--ammonia ligase activity
has exact synonym: UTP:ammonia ligase (ADP-forming)
has exact synonym: cytidine 5'-triphosphate synthetase activity
has exact synonym: cytidine triphosphate synthetase activity
has exact synonym: uridine triphosphate aminase activity
has OBO namespace: molecular_function
id: GO:0003883
in subset: gosubset prok
type: Class
subclass of: GO_0016879

D-amino-acid oxidase activity
IAO_0000115: Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
has db xref: EC:1.4.3.3
has db xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN
has db xref: RHEA:21819
has db xref: Reactome:REACT_106309
has db xref: Reactome:REACT_113962
has db xref: Reactome:REACT_114219
has db xref: Reactome:REACT_115360
has db xref: Reactome:REACT_115482
has db xref: Reactome:REACT_17049
has db xref: Reactome:REACT_31469
has db xref: Reactome:REACT_34652
has db xref: Reactome:REACT_77556
has db xref: Reactome:REACT_77723
has db xref: Reactome:REACT_88459
has db xref: Reactome:REACT_88556
has db xref: Reactome:REACT_88963
has db xref: Reactome:REACT_93508
has db xref: Reactome:REACT_93867
has exact synonym: D-amino-acid:oxygen oxidoreductase (deaminating)
has exact synonym: L-amino acid:O2 oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: new yellow enzyme
id: GO:0003884
in subset: gosubset prok
type: Class
subclass of: GO_0016641

D-arabinono-1,4-lactone oxidase activity
IAO_0000115: Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).
has db xref: EC:1.1.3.37
has db xref: KEGG:R02715
has db xref: MetaCyc:1.1.3.37-RXN
has db xref: RHEA:23759
has exact synonym: D-arabinono-1,4-lactone:oxygen oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0003885
in subset: gosubset prok
type: Class
subclass of: GO_0016899

DNA (cytosine-5-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
has alternative id: GO:0008326
has broad synonym: DNA cytosine methylase activity
has broad synonym: DNA-cytosine methyltransferase activity
has broad synonym: cytosine DNA methylase activity
has broad synonym: cytosine DNA methyltransferase activity
has broad synonym: deoxyribonucleic methylase activity
has db xref: EC:2.1.1.37
has db xref: MetaCyc:2.1.1.73-RXN
has exact synonym: DNA 5-cytosine methylase activity
has exact synonym: DNA cytosine C(5) methylase activity
has exact synonym: DNA cytosine C5 methylase activity
has exact synonym: DNA-cytosine 5-methylase activity
has exact synonym: S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity
has exact synonym: cytosine 5-methyltransferase activity
has exact synonym: cytosine-specific DNA methyltransferase activity
has exact synonym: deoxyribonucleic (cytosine-5-)-methyltransferase activity
has exact synonym: deoxyribonucleic acid (cytosine-5-)-methyltransferase activity
has narrow synonym: site-specific DNA-methyltransferase (cytosine-specific) activity
has OBO namespace: molecular_function
has related synonym: methylphosphotriester-DNA methyltransferase activity
has related synonym: modification methylase activity
has related synonym: restriction-modification system activity
has related synonym: type II DNA methylase activity
id: GO:0003886
in subset: gosubset prok
type: Class
comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37).
subclass of: GO_0008757
subclass of: GO_0009008

DNA-directed DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer.
has alternative id: GO:0003888
has alternative id: GO:0003889
has alternative id: GO:0003890
has alternative id: GO:0003891
has alternative id: GO:0003893
has alternative id: GO:0003894
has alternative id: GO:0003895
has alternative id: GO:0008723
has alternative id: GO:0015999
has alternative id: GO:0016000
has alternative id: GO:0016448
has alternative id: GO:0016449
has alternative id: GO:0016450
has alternative id: GO:0016451
has alternative id: GO:0016452
has alternative id: GO:0019984
has broad synonym: duplicase
has db xref: EC:2.7.7.7
has db xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN
has db xref: Reactome:REACT_101168
has db xref: Reactome:REACT_101456
has db xref: Reactome:REACT_101578
has db xref: Reactome:REACT_102164
has db xref: Reactome:REACT_1024
has db xref: Reactome:REACT_102850
has db xref: Reactome:REACT_102905
has db xref: Reactome:REACT_103072
has db xref: Reactome:REACT_103285
has db xref: Reactome:REACT_103439
has db xref: Reactome:REACT_103520
has db xref: Reactome:REACT_103531
has db xref: Reactome:REACT_104153
has db xref: Reactome:REACT_104851
has db xref: Reactome:REACT_104914
has db xref: Reactome:REACT_104973
has db xref: Reactome:REACT_105070
has db xref: Reactome:REACT_105462
has db xref: Reactome:REACT_105659
has db xref: Reactome:REACT_105733
has db xref: Reactome:REACT_105794
has db xref: Reactome:REACT_105961
has db xref: Reactome:REACT_106002
has db xref: Reactome:REACT_106057
has db xref: Reactome:REACT_106334
has db xref: Reactome:REACT_106776
has db xref: Reactome:REACT_106994
has db xref: Reactome:REACT_107125
has db xref: Reactome:REACT_107358
has db xref: Reactome:REACT_107480
has db xref: Reactome:REACT_107781
has db xref: Reactome:REACT_107879
has db xref: Reactome:REACT_107930
has db xref: Reactome:REACT_108241
has db xref: Reactome:REACT_108640
has db xref: Reactome:REACT_108802
has db xref: Reactome:REACT_109069
has db xref: Reactome:REACT_109329
has db xref: Reactome:REACT_109542
has db xref: Reactome:REACT_109593
has db xref: Reactome:REACT_109749
has db xref: Reactome:REACT_109858
has db xref: Reactome:REACT_109873
has db xref: Reactome:REACT_109947
has db xref: Reactome:REACT_110252
has db xref: Reactome:REACT_112231
has db xref: Reactome:REACT_112289
has db xref: Reactome:REACT_112468
has db xref: Reactome:REACT_1196
has db xref: Reactome:REACT_1324
has db xref: Reactome:REACT_1479
has db xref: Reactome:REACT_2016
has db xref: Reactome:REACT_2214
has db xref: Reactome:REACT_2224
has db xref: Reactome:REACT_28103
has db xref: Reactome:REACT_28619
has db xref: Reactome:REACT_28865
has db xref: Reactome:REACT_29011
has db xref: Reactome:REACT_29030
has db xref: Reactome:REACT_292

proliferating cell nuclear antigen
IAO_0000115: OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair.
has alternative id: GO:0005661
has exact synonym: PCNA
has OBO namespace: molecular_function
id: GO:0003892
type: Class
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
deprecated: true

DNA primase activity
IAO_0000115: Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase.
has alternative id: GO:0003897
has alternative id: GO:0003898
has db xref: EC:2.7.7.-
has OBO namespace: molecular_function
id: GO:0003896
in subset: gosubset prok
type: Class
subclass of: DNA-directed RNA polymerase activity

DNA-directed RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has alternative id: GO:0000129
has broad synonym: transcriptase
has db xref: EC:2.7.7.6
has db xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN
has db xref: Reactome:REACT_100344
has db xref: Reactome:REACT_100410
has db xref: Reactome:REACT_101111
has db xref: Reactome:REACT_101858
has db xref: Reactome:REACT_101953
has db xref: Reactome:REACT_101994
has db xref: Reactome:REACT_102121
has db xref: Reactome:REACT_102441
has db xref: Reactome:REACT_102466
has db xref: Reactome:REACT_102706
has db xref: Reactome:REACT_102769
has db xref: Reactome:REACT_102802
has db xref: Reactome:REACT_102951
has db xref: Reactome:REACT_103006
has db xref: Reactome:REACT_103501
has db xref: Reactome:REACT_103871
has db xref: Reactome:REACT_103959
has db xref: Reactome:REACT_104171
has db xref: Reactome:REACT_104334
has db xref: Reactome:REACT_104618
has db xref: Reactome:REACT_105022
has db xref: Reactome:REACT_105177
has db xref: Reactome:REACT_105539
has db xref: Reactome:REACT_105890
has db xref: Reactome:REACT_106497
has db xref: Reactome:REACT_106762
has db xref: Reactome:REACT_106790
has db xref: Reactome:REACT_108159
has db xref: Reactome:REACT_1082
has db xref: Reactome:REACT_108279
has db xref: Reactome:REACT_108323
has db xref: Reactome:REACT_108648
has db xref: Reactome:REACT_109090
has db xref: Reactome:REACT_109161
has db xref: Reactome:REACT_110305
has db xref: Reactome:REACT_110458
has db xref: Reactome:REACT_110741
has db xref: Reactome:REACT_112737
has db xref: Reactome:REACT_112968
has db xref: Reactome:REACT_113943
has db xref: Reactome:REACT_12505
has db xref: Reactome:REACT_1611
has db xref: Reactome:REACT_1817
has db xref: Reactome:REACT_209
has db xref: Reactome:REACT_28131
has db xref: Reactome:REACT_28303
has db xref: Reactome:REACT_28467
has db xref: Reactome:REACT_28810
has db xref: Reactome:REACT_28970
has db xref: Reactome:REACT_29155
has db xref: Reactome:REACT_29681
has db xref: Reactome:REACT_29818
has db xref: Reactome:REACT_30335
has db xref: Reactome:REACT_31554
has db xref: Reactome:REACT_31831
has db xref: Reactome:REACT_32533
has db xref: Reactome:REACT_32905
has db xref: Reactome:REACT_34518
has db xref: Reactome:REACT_40
has db xref: Reactome:REACT_581
has db xref: Reactome:REACT_6172
has db xref: Reactome:REACT_6184
has db xref: Reactome:REACT_6208
has db xref: Reactome:REACT_6240
has db xref: Reactome:REACT_6325
has db xref: Reactome:REACT_77161
has db xref: Reactome:REACT_77417
has db xref: Reactome:REACT_77879
has db xref: Reactome:REACT_78158
has db xref: Reactome:REACT_79759
has db xref: Reactome:REACT_7998
has db xref: Reactome:REACT_80162
has db xref: Reactome:REACT_80268
has db xref: Reactome:REACT_80325
has db xref: Reactome:REACT_80396

DNA-directed RNA polymerase I activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
IAO_0100001: GO:0003899
has OBO namespace: molecular_function
id: GO:0003900
type: Class
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'.
deprecated: true

DNA-directed RNA polymerase II activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
IAO_0100001: GO:0003899
has OBO namespace: molecular_function
id: GO:0003901
type: Class
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'.
deprecated: true

DNA-directed RNA polymerase III activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
IAO_0100001: GO:0003899
has OBO namespace: molecular_function
id: GO:0003902
type: Class
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'.
deprecated: true

deoxyribodipyrimidine photo-lyase activity
IAO_0000115: Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.
has db xref: EC:4.1.99.3
has db xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN
has exact synonym: CPD photolyase activity
has exact synonym: DNA cyclobutane dipyrimidine photolyase activity
has exact synonym: PhrB photolyase activity
has exact synonym: deoxyribocyclobutadipyrimidine pyrimidine-lyase activity
has exact synonym: deoxyribodipyrimidine photolyase activity
has exact synonym: deoxyribonucleate pyrimidine dimer lyase (photosensitive)
has exact synonym: deoxyribonucleic cyclobutane dipyrimidine photolyase activity
has exact synonym: deoxyribonucleic photolyase activity
has exact synonym: dipyrimidine photolyase (photosensitive)
has exact synonym: photolyase activity
has exact synonym: phr A photolyase activity
has OBO namespace: molecular_function
has related synonym: DNA-photoreactivating enzyme
has related synonym: PRE
has related synonym: photoreactivating enzyme activity
id: GO:0003904
in subset: gosubset prok
type: Class
subclass of: DNA photolyase activity

alkylbase DNA N-glycosylase activity
IAO_0000115: Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
has alternative id: GO:0004036
has broad synonym: alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
has db xref: EC:3.2.2.21
has db xref: MetaCyc:3.2.2.21-RXN
has exact synonym: DNA glycosidase II activity
has exact synonym: DNA-3-methyladenine glycosidase II activity
has exact synonym: alkylbase DNA glycosidase activity
has OBO namespace: molecular_function
has related synonym: 3-methyladenine DNA glycosylase II
has related synonym: AlkA
has related synonym: DNA-3-methyladenine glycosylase II
has related synonym: deoxyribonucleate 3-methyladenine glycosidase II
id: GO:0003905
in subset: gosubset prok
type: Class
subclass of: GO_0019104

DNA-(apurinic or apyrimidinic site) lyase activity
IAO_0000115: Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
has broad synonym: phage-T4 UV endonuclease
has db xref: EC:4.2.99.18
has db xref: MetaCyc:4.2.99.18-RXN
has db xref: Reactome:REACT_103252
has db xref: Reactome:REACT_1215
has db xref: Reactome:REACT_32396
has db xref: Reactome:REACT_55273
has db xref: Reactome:REACT_79844
has db xref: Reactome:REACT_83849
has db xref: Reactome:REACT_85754
has db xref: Reactome:REACT_96683
has db xref: Reactome:REACT_97368
has db xref: Reactome:REACT_99910
has exact synonym: AP lyase activity
has exact synonym: AP site-DNA 5'-phosphomonoester-lyase activity
has exact synonym: DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity
has exact synonym: deoxyribonuclease (apurinic or apyrimidinic) activity
has exact synonym: endodeoxyribonuclease (apurinic or apyrimidinic) activity
has narrow synonym: AP endonuclease class I activity
has narrow synonym: E. coli endonuclease III activity
has narrow synonym: Micrococcus luteus UV endonuclease activity
has narrow synonym: Phage-T(4) UV endonuclease activity
has narrow synonym: Phage-T4 UV endonuclease activity
has narrow synonym: micrococcus luteus UV endonuclease
has OBO namespace: molecular_function
has related synonym: E. coli endonuclease III
has related synonym: X-ray endonuclease III
has related synonym: endonuclease VIII activity
id: GO:0003906
in subset: gosubset prok
type: Class
subclass of: GO_0016835

methylated-DNA-[protein]-cysteine S-methyltransferase activity
IAO_0000115: Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
has broad synonym: O6-alkylguanine-DNA alkyltransferase
has db xref: EC:2.1.1.63
has db xref: MetaCyc:2.1.1.63-RXN
has db xref: Reactome:REACT_102488
has db xref: Reactome:REACT_103267
has db xref: Reactome:REACT_103543
has db xref: Reactome:REACT_104382
has db xref: Reactome:REACT_108289
has db xref: Reactome:REACT_115725
has db xref: Reactome:REACT_1876
has db xref: Reactome:REACT_28063
has db xref: Reactome:REACT_29167
has db xref: Reactome:REACT_31652
has db xref: Reactome:REACT_82211
has db xref: Reactome:REACT_89238
has db xref: Reactome:REACT_92208
has db xref: Reactome:REACT_94426
has db xref: Reactome:REACT_96080
has db xref: Reactome:REACT_98636
has exact synonym: 6-O-methylguanine-DNA methyltransferase activity
has exact synonym: DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity
has exact synonym: DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity
has exact synonym: MGMT
has exact synonym: O-6-methylguanine-DNA-alkyltransferase activity
has exact synonym: methylated-DNA-protein-cysteine S-methyltransferase activity
has OBO namespace: molecular_function
id: GO:0003908
in subset: gosubset prok
type: Class
subclass of: GO_0008172

DNA ligase activity
IAO_0000115: Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.
has db xref: EC:6.5.1.-
has db xref: Reactome:REACT_100095
has db xref: Reactome:REACT_100592
has db xref: Reactome:REACT_101774
has db xref: Reactome:REACT_102755
has db xref: Reactome:REACT_102810
has db xref: Reactome:REACT_102989
has db xref: Reactome:REACT_103194
has db xref: Reactome:REACT_103238
has db xref: Reactome:REACT_103332
has db xref: Reactome:REACT_103589
has db xref: Reactome:REACT_103607
has db xref: Reactome:REACT_103914
has db xref: Reactome:REACT_104033
has db xref: Reactome:REACT_105041
has db xref: Reactome:REACT_105804
has db xref: Reactome:REACT_106130
has db xref: Reactome:REACT_106909
has db xref: Reactome:REACT_106919
has db xref: Reactome:REACT_107577
has db xref: Reactome:REACT_107734
has db xref: Reactome:REACT_107864
has db xref: Reactome:REACT_108464
has db xref: Reactome:REACT_108675
has db xref: Reactome:REACT_109229
has db xref: Reactome:REACT_109434
has db xref: Reactome:REACT_109730
has db xref: Reactome:REACT_109841
has db xref: Reactome:REACT_110352
has db xref: Reactome:REACT_112118
has db xref: Reactome:REACT_112246
has db xref: Reactome:REACT_113076
has db xref: Reactome:REACT_113217
has db xref: Reactome:REACT_113661
has db xref: Reactome:REACT_113851
has db xref: Reactome:REACT_114038
has db xref: Reactome:REACT_114285
has db xref: Reactome:REACT_114706
has db xref: Reactome:REACT_115886
has db xref: Reactome:REACT_12
has db xref: Reactome:REACT_1247
has db xref: Reactome:REACT_1659
has db xref: Reactome:REACT_1889
has db xref: Reactome:REACT_2181
has db xref: Reactome:REACT_29134
has db xref: Reactome:REACT_29359
has db xref: Reactome:REACT_29498
has db xref: Reactome:REACT_29665
has db xref: Reactome:REACT_29882
has db xref: Reactome:REACT_30614
has db xref: Reactome:REACT_31624
has db xref: Reactome:REACT_31707
has db xref: Reactome:REACT_31800
has db xref: Reactome:REACT_32203
has db xref: Reactome:REACT_32488
has db xref: Reactome:REACT_33776
has db xref: Reactome:REACT_34177
has db xref: Reactome:REACT_34490
has db xref: Reactome:REACT_527
has db xref: Reactome:REACT_77023
has db xref: Reactome:REACT_77057
has db xref: Reactome:REACT_78542
has db xref: Reactome:REACT_78969
has db xref: Reactome:REACT_79227
has db xref: Reactome:REACT_79753
has db xref: Reactome:REACT_7994
has db xref: Reactome:REACT_80840
has db xref: Reactome:REACT_81358
has db xref: Reactome:REACT_81832
has db xref: Reactome:REACT_819
has db xref: Reactome:REACT_81990
has db xref: Reactome:REACT_82032
has db xref: Reactome:REACT_82667
has db xref: Reactome:REACT_82701
has db xref: Reactome:REACT_82930
has db xref: Reactome:REACT_83571
has db xref: Reactome:REACT_84527
has db xref: Reactome:REACT_84993
has db xref: Reactome:REACT_85398

DNA ligase (ATP) activity
IAO_0000115: Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
has broad synonym: DNA joinase activity
has broad synonym: deoxyribonucleate ligase
has broad synonym: deoxyribonucleic acid joinase
has broad synonym: deoxyribonucleic acid ligase
has broad synonym: deoxyribonucleic joinase
has broad synonym: deoxyribonucleic ligase
has broad synonym: polynucleotide ligase
has db xref: EC:6.5.1.1
has db xref: MetaCyc:DNA-LIGASE-ATP-RXN
has exact synonym: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
has exact synonym: polydeoxyribonucleotide synthase (ATP) activity
has exact synonym: polynucleotide ligase (ATP) activity
has OBO namespace: molecular_function
has related synonym: DNA repair enzyme activity
has related synonym: DNA-joining enzyme
has related synonym: deoxyribonucleic acid repair enzyme
has related synonym: deoxyribonucleic acid-joining enzyme
has related synonym: deoxyribonucleic repair enzyme
has related synonym: deoxyribonucleic-joining enzyme
has related synonym: sealase activity
id: GO:0003910
in subset: gosubset prok
type: Class
subclass of: DNA ligase activity

DNA ligase (NAD+) activity
IAO_0000115: Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
has broad synonym: DNA joinase activity
has broad synonym: deoxyribonucleate ligase
has broad synonym: deoxyribonucleic acid joinase
has broad synonym: deoxyribonucleic acid ligase
has broad synonym: deoxyribonucleic joinase
has broad synonym: deoxyribonucleic ligase
has broad synonym: polynucleotide ligase
has db xref: EC:6.5.1.2
has db xref: MetaCyc:DNA-LIGASE-NAD+-RXN
has exact synonym: DNA ligase (NAD)
has exact synonym: Polydeoxyribonucleotide synthase (NAD(+)) activity
has exact synonym: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
has exact synonym: polydeoxyribonucleotide synthase (NAD)
has exact synonym: polydeoxyribonucleotide synthase (NAD+) activity
has exact synonym: polynucleotide ligase (NAD(+)) activity
has exact synonym: polynucleotide ligase (NAD)
has exact synonym: polynucleotide ligase (NAD+) activity
has exact synonym: polynucleotide ligase (nicotinamide adenine dinucleotide)
has exact synonym: polynucleotide synthetase (nicotinamide adenine dinucleotide)
has exact synonym: polynucleotide synthetase activity
has OBO namespace: molecular_function
has related synonym: DNA repair enzyme activity
has related synonym: DNA-joining enzyme
has related synonym: deoxyribonucleic repair enzyme
has related synonym: deoxyribonucleic-joining enzyme
id: GO:0003911
in subset: gosubset prok
type: Class
subclass of: DNA ligase activity

DNA nucleotidylexotransferase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
has db xref: EC:2.7.7.31
has db xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN
has exact synonym: addase activity
has exact synonym: deoxynucleotidyl terminal transferase activity
has exact synonym: deoxyribonucleic acid nucleotidyltransferase activity
has exact synonym: deoxyribonucleic nucleotidyltransferase activity
has exact synonym: nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity
has exact synonym: terminal deoxynucleotide transferase activity
has exact synonym: terminal deoxynucleotidyltransferase activity
has exact synonym: terminal deoxyribonucleotidyltransferase activity
has exact synonym: terminal transferase activity
has OBO namespace: molecular_function
has related synonym: TdT
has related synonym: terminal addition enzyme activity
id: GO:0003912
type: Class
subclass of: GO_0016779

DNA photolyase activity
IAO_0000115: Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA.
has db xref: EC:4.1.99.-
has db xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN
has OBO namespace: molecular_function
id: GO:0003913
in subset: gosubset prok
type: Class
subclass of: GO_0016830

DNA (6-4) photolyase activity
IAO_0000115: Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA.
has db xref: EC:4.1.99.13
has db xref: MetaCyc:RXN-10771
has OBO namespace: molecular_function
id: GO:0003914
type: Class
subclass of: DNA photolyase activity

DNA topoisomerase activity
IAO_0000115: Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
has alternative id: GO:0009387
has db xref: EC:5.99.1.-
has db xref: MetaCyc:5.99.1.2-RXN
has OBO namespace: molecular_function
id: GO:0003916
in subset: gosubset prok
type: Class
subclass of: DNA binding
subclass of: GO_0016853

DNA topoisomerase type I activity
IAO_0000115: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
has broad synonym: deoxyribonucleate topoisomerase
has broad synonym: topoisomerase
has db xref: EC:5.99.1.2
has db xref: MetaCyc:5.99.1.2-RXN
has exact synonym: type I DNA topoisomerase activity
has exact synonym: type I topoisomerase activity
has narrow synonym: DNA topoisomerase I activity
has OBO namespace: molecular_function
has related synonym: nicking-closing enzyme activity
has related synonym: omega-protein activity
has related synonym: relaxing enzyme activity
has related synonym: swivelase activity
has related synonym: untwisting enzyme activity
id: GO:0003917
in subset: gosubset prok
type: Class
comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
subclass of: DNA topoisomerase activity

DNA topoisomerase (ATP-hydrolyzing) activity
IAO_0000115: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
has broad synonym: DNA topoisomerase (ATP-hydrolysing)
has broad synonym: deoxyribonucleate topoisomerase
has broad synonym: topoisomerase
has db xref: EC:5.99.1.3
has db xref: MetaCyc:5.99.1.3-RXN
has db xref: Wikipedia:Type_II_topoisomerase
has exact synonym: DNA gyrase activity
has exact synonym: DNA topoisomerase IV activity
has exact synonym: DNA topoisomerase type II activity
has exact synonym: DNA-gyrase activity
has exact synonym: deoxyribonucleic topoisomerase activity
has exact synonym: topoisomerase II
has exact synonym: type II DNA topoisomerase activity
has OBO namespace: molecular_function
has related synonym: DNA topoisomerase II
id: GO:0003918
in subset: gosubset prok
type: Class
subclass of: DNA topoisomerase activity
subclass of: GO_0008094

FMN adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + FMN = diphosphate + FAD.
has db xref: EC:2.7.7.2
has db xref: KEGG:R00161
has db xref: MetaCyc:FADSYN-RXN
has db xref: RHEA:17240
has db xref: Reactome:REACT_100498
has db xref: Reactome:REACT_101323
has db xref: Reactome:REACT_101363
has db xref: Reactome:REACT_103632
has db xref: Reactome:REACT_11128
has db xref: Reactome:REACT_32090
has db xref: Reactome:REACT_32724
has db xref: Reactome:REACT_34649
has db xref: Reactome:REACT_80112
has db xref: Reactome:REACT_81244
has db xref: Reactome:REACT_85313
has db xref: Reactome:REACT_85342
has db xref: Reactome:REACT_85926
has db xref: Reactome:REACT_91206
has db xref: Reactome:REACT_92304
has db xref: Reactome:REACT_92992
has exact synonym: ATP:FMN adenylyltransferase activity
has exact synonym: FAD diphosphorylase activity
has exact synonym: FAD pyrophosphorylase activity
has exact synonym: FAD synthetase activity
has exact synonym: adenosine triphosphate-riboflavin mononucleotide transadenylase activity
has exact synonym: adenosine triphosphate-riboflavine mononucleotide transadenylase activity
has exact synonym: flavin adenine dinucleotide synthetase activity
has exact synonym: riboflavin adenine dinucleotide pyrophosphorylase activity
has exact synonym: riboflavin mononucleotide adenylyltransferase activity
has exact synonym: riboflavine adenine dinucleotide adenylyltransferase activity
has OBO namespace: molecular_function
id: GO:0003919
in subset: gosubset prok
type: Class
subclass of: GO_0070566

GMP reductase activity
IAO_0000115: Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH.
has db xref: EC:1.7.1.7
has db xref: KEGG:R01134
has db xref: MetaCyc:GMP-REDUCT-RXN
has db xref: RHEA:17188
has db xref: Reactome:REACT_21383
has exact synonym: NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)
has exact synonym: NADPH:GMP oxidoreductase (deaminating) activity
has exact synonym: NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity
has exact synonym: guanosine 5'-monophosphate oxidoreductase activity
has exact synonym: guanosine 5'-monophosphate reductase activity
has exact synonym: guanosine 5'-phosphate reductase activity
has exact synonym: guanosine monophosphate reductase activity
has exact synonym: inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
has OBO namespace: molecular_function
has related synonym: guanylate reductase activity
id: GO:0003920
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:1.6.6.8.
subclass of: GO_0016657

GMP synthase activity
IAO_0000115: Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP.
has db xref: EC:6.3.4.1
has db xref: MetaCyc:GMP-SYN-NH3-RXN
has db xref: RHEA:18304
has db xref: Reactome:REACT_101174
has db xref: Reactome:REACT_105280
has db xref: Reactome:REACT_106308
has db xref: Reactome:REACT_107658
has db xref: Reactome:REACT_108131
has db xref: Reactome:REACT_109470
has db xref: Reactome:REACT_110787
has db xref: Reactome:REACT_114078
has db xref: Reactome:REACT_28584
has db xref: Reactome:REACT_29905
has db xref: Reactome:REACT_32520
has db xref: Reactome:REACT_32733
has db xref: Reactome:REACT_37631
has db xref: Reactome:REACT_62336
has db xref: Reactome:REACT_628
has db xref: Reactome:REACT_78067
has db xref: Reactome:REACT_82243
has db xref: Reactome:REACT_90423
has db xref: Reactome:REACT_91249
has db xref: Reactome:REACT_96003
has db xref: Reactome:REACT_96357
has exact synonym: XMP aminase activity
has exact synonym: Xanthosine-5'-phosphate--ammonia ligase activity
has exact synonym: guanylate synthetase activity
has exact synonym: xanthosine 5'-monophosphate aminase activity
has exact synonym: xanthosine-5'-phosphate-ammonia ligase activity
has exact synonym: xanthosine-5'-phosphate:ammonia ligase (AMP-forming)
has OBO namespace: molecular_function
id: GO:0003921
type: Class
subclass of: GO_0016879

GMP synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.
has db xref: EC:6.3.5.2
has db xref: MetaCyc:GMP-SYN-GLUT-RXN
has db xref: RHEA:11683
has db xref: Reactome:REACT_116095
has db xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing)
has exact synonym: GMP synthase (glutamine-hydrolysing)
has exact synonym: GMP synthetase (glutamine-hydrolysing)
has exact synonym: GMP synthetase (glutamine-hydrolyzing) activity
has exact synonym: glutamine amidotransferase activity
has exact synonym: guanosine 5'-monophosphate synthetase activity
has exact synonym: guanosine monophosphate synthetase (glutamine-hydrolyzing)
has exact synonym: guanylate synthetase (glutamine-hydrolyzing)
has exact synonym: xanthosine 5'-phosphate amidotransferase activity
has exact synonym: xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
has OBO namespace: molecular_function
id: GO:0003922
in subset: gosubset prok
type: Class
subclass of: GO_0016884

GPI-anchor transamidase activity
IAO_0000115: Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.
has db xref: EC:3.-.-.-
has db xref: Reactome:REACT_100692
has db xref: Reactome:REACT_101782
has db xref: Reactome:REACT_103715
has db xref: Reactome:REACT_113833
has db xref: Reactome:REACT_1777
has db xref: Reactome:REACT_34799
has db xref: Reactome:REACT_90230
has db xref: Reactome:REACT_92319
has OBO namespace: molecular_function
id: GO:0003923
type: Class
subclass of: GO_0016787

GTPase activity
IAO_0000115: Catalysis of the reaction: GTP + H2O = GDP + phosphate.
has broad synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
has db xref: RHEA:19672
has db xref: Reactome:REACT_100432
has db xref: Reactome:REACT_100708
has db xref: Reactome:REACT_101121
has db xref: Reactome:REACT_101520
has db xref: Reactome:REACT_101563
has db xref: Reactome:REACT_101678
has db xref: Reactome:REACT_102040
has db xref: Reactome:REACT_102208
has db xref: Reactome:REACT_102307
has db xref: Reactome:REACT_102371
has db xref: Reactome:REACT_102510
has db xref: Reactome:REACT_102532
has db xref: Reactome:REACT_103518
has db xref: Reactome:REACT_104081
has db xref: Reactome:REACT_104477
has db xref: Reactome:REACT_104739
has db xref: Reactome:REACT_105323
has db xref: Reactome:REACT_105697
has db xref: Reactome:REACT_105708
has db xref: Reactome:REACT_105854
has db xref: Reactome:REACT_106121
has db xref: Reactome:REACT_106217
has db xref: Reactome:REACT_106301
has db xref: Reactome:REACT_106528
has db xref: Reactome:REACT_107176
has db xref: Reactome:REACT_107306
has db xref: Reactome:REACT_107730
has db xref: Reactome:REACT_107820
has db xref: Reactome:REACT_108363
has db xref: Reactome:REACT_108653
has db xref: Reactome:REACT_108825
has db xref: Reactome:REACT_108837
has db xref: Reactome:REACT_109360
has db xref: Reactome:REACT_109897
has db xref: Reactome:REACT_110131
has db xref: Reactome:REACT_110443
has db xref: Reactome:REACT_110557
has db xref: Reactome:REACT_110859
has db xref: Reactome:REACT_110879
has db xref: Reactome:REACT_110931
has db xref: Reactome:REACT_111994
has db xref: Reactome:REACT_112104
has db xref: Reactome:REACT_112254
has db xref: Reactome:REACT_112389
has db xref: Reactome:REACT_112587
has db xref: Reactome:REACT_112651
has db xref: Reactome:REACT_112671
has db xref: Reactome:REACT_113058
has db xref: Reactome:REACT_113209
has db xref: Reactome:REACT_113727
has db xref: Reactome:REACT_113832
has db xref: Reactome:REACT_113952
has db xref: Reactome:REACT_113954
has db xref: Reactome:REACT_114148
has db xref: Reactome:REACT_114153
has db xref: Reactome:REACT_114188
has db xref: Reactome:REACT_114210
has db xref: Reactome:REACT_114331
has db xref: Reactome:REACT_114379
has db xref: Reactome:REACT_114384
has db xref: Reactome:REACT_114532
has db xref: Reactome:REACT_114620
has db xref: Reactome:REACT_114824
has db xref: Reactome:REACT_115229
has db xref: Reactome:REACT_115324
has db xref: Reactome:REACT_12396
has db xref: Reactome:REACT_12397
has db xref: Reactome:REACT_12456
has db xref: Reactome:REACT_12612
has db xref: Reactome:REACT_15316
has db xref: Reactome:REACT_15335
has db xref: Reactome:REACT_15449
has db xref: Reactome:REACT_15495
has db xref: Reactome:REACT_19123
has db xref: Reactome:REACT_19178
has db xref: Reactome:REACT_19186
has db xref: Reactome:REACT_19194

small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
IAO_0100001: GO:0003924
has OBO namespace: molecular_function
id: GO:0003925
type: Class
comment: This term was made obsolete because it represents a gene product and contains cellular component information.
deprecated: true

ARF small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
IAO_0100001: GO:0003924
consider: GO:0016191
consider: GO:0016192
has OBO namespace: molecular_function
id: GO:0003926
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

heterotrimeric G-protein GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase.
IAO_0100001: GO:0003924
IAO_0100001: GO:0005834
has OBO namespace: molecular_function
id: GO:0003927
type: Class
comment: This term was made obsolete because it represents a cellular component.
deprecated: true

RAB small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
IAO_0100001: GO:0003924
consider: GO:0016191
consider: GO:0016192
has OBO namespace: molecular_function
id: GO:0003928
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

RAN small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
IAO_0100001: GO:0003924
consider: GO:0006606
has OBO namespace: molecular_function
id: GO:0003929
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

RAS small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
IAO_0100001: GO:0003924
consider: GO:0001558
has OBO namespace: molecular_function
id: GO:0003930
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

Rho small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
IAO_0100001: GO:0003924
consider: GO:0007010
has OBO namespace: molecular_function
id: GO:0003931
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

SAR small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
IAO_0100001: GO:0003924
consider: GO:0046903
has OBO namespace: molecular_function
id: GO:0003932
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

GTP cyclohydrolase activity
IAO_0000115: Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.
has db xref: EC:3.5.4.-
has OBO namespace: molecular_function
id: GO:0003933
in subset: gosubset prok
type: Class
subclass of: GO_0019238

GTP cyclohydrolase I activity
IAO_0000115: Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
has db xref: EC:3.5.4.16
has db xref: KEGG:R00424
has db xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN
has db xref: RHEA:17476
has db xref: Reactome:REACT_111143
has exact synonym: GTP 7,8-8,9-dihydrolase activity
has exact synonym: GTP 8-formylhydrolase activity
has exact synonym: dihydroneopterin triphosphate synthase activity
has exact synonym: guanosine triphosphate 8-deformylase activity
has exact synonym: guanosine triphosphate cyclohydrolase activity
has OBO namespace: molecular_function
id: GO:0003934
in subset: gosubset prok
type: Class
subclass of: GTP cyclohydrolase activity

GTP cyclohydrolase II activity
IAO_0000115: Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+).
has db xref: EC:3.5.4.25
has db xref: KEGG:R00425
has db xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN
has db xref: RHEA:23707
has exact synonym: GTP 7,8-8,9-dihydrolase (diphosphate-forming)
has exact synonym: GTP-8-formylhydrolase activity
has OBO namespace: molecular_function
has related synonym: guanosine triphosphate cyclohydrolase II
id: GO:0003935
in subset: gosubset prok
type: Class
subclass of: GTP cyclohydrolase activity

hydrogen-transporting two-sector ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out).
consider: GO:0046933
consider: GO:0046961
has alternative id: GO:0004006
has alternative id: GO:0008729
has exact synonym: proton-transporting two-sector ATPase activity
has OBO namespace: molecular_function
id: GO:0003936
type: Class
comment: This term was made obsolete because it refers to a bifunctional gene product.
deprecated: true

IMP cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
has db xref: EC:3.5.4.10
has db xref: MetaCyc:IMPCYCLOHYDROLASE-RXN
has db xref: RHEA:18448
has db xref: Reactome:REACT_100264
has db xref: Reactome:REACT_101327
has db xref: Reactome:REACT_101441
has db xref: Reactome:REACT_101852
has db xref: Reactome:REACT_105279
has db xref: Reactome:REACT_107619
has db xref: Reactome:REACT_110740
has db xref: Reactome:REACT_116131
has db xref: Reactome:REACT_263
has db xref: Reactome:REACT_29038
has db xref: Reactome:REACT_30340
has db xref: Reactome:REACT_30737
has db xref: Reactome:REACT_79659
has db xref: Reactome:REACT_80364
has db xref: Reactome:REACT_80795
has db xref: Reactome:REACT_80881
has db xref: Reactome:REACT_83814
has db xref: Reactome:REACT_93074
has db xref: Reactome:REACT_93482
has db xref: Reactome:REACT_94292
has db xref: Reactome:REACT_98029
has exact synonym: IMP 1,2-hydrolase (decyclizing)
has exact synonym: IMP synthetase activity
has exact synonym: inosinate cyclohydrolase activity
has exact synonym: inosinicase activity
has OBO namespace: molecular_function
id: GO:0003937
in subset: gosubset prok
type: Class
subclass of: GO_0019238

IMP dehydrogenase activity
IAO_0000115: Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
has db xref: EC:1.1.1.205
has db xref: MetaCyc:IMP-DEHYDROG-RXN
has db xref: RHEA:11711
has db xref: Reactome:REACT_102501
has db xref: Reactome:REACT_110875
has db xref: Reactome:REACT_116090
has db xref: Reactome:REACT_1488
has db xref: Reactome:REACT_31646
has db xref: Reactome:REACT_32201
has db xref: Reactome:REACT_33579
has db xref: Reactome:REACT_33597
has db xref: Reactome:REACT_33701
has db xref: Reactome:REACT_77612
has db xref: Reactome:REACT_79622
has db xref: Reactome:REACT_80105
has db xref: Reactome:REACT_86742
has db xref: Reactome:REACT_86832
has db xref: Reactome:REACT_88830
has db xref: Reactome:REACT_94520
has db xref: Reactome:REACT_94662
has db xref: Reactome:REACT_96045
has db xref: Reactome:REACT_96517
has db xref: Reactome:REACT_96945
has db xref: Reactome:REACT_97319
has db xref: Reactome:REACT_98553
has exact synonym: IMP oxidoreductase activity
has exact synonym: IMP:NAD+ oxidoreductase activity
has exact synonym: inosine 5'-monophosphate dehydrogenase activity
has exact synonym: inosine monophosphate dehydrogenase activity
has exact synonym: inosine monophosphate oxidoreductase activity
has exact synonym: inosine-5'-phosphate dehydrogenase activity
has OBO namespace: molecular_function
has related synonym: inosinate dehydrogenase activity
has related synonym: inosinic acid dehydrogenase activity
id: GO:0003938
in subset: gosubset prok
type: Class
subclass of: GO_0016616

L-iditol 2-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
has broad synonym: polyol dehydrogenase activity
has db xref: EC:1.1.1.14
has db xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN
has db xref: RHEA:10163
has exact synonym: L-iditol:NAD oxidoreductase activity
has exact synonym: L-iditol:NAD+ 5-oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: L-iditol (sorbitol) dehydrogenase activity
has related synonym: NAD+-dependent sorbitol dehydrogenase activity
has related synonym: NAD-dependent sorbitol dehydrogenase activity
has related synonym: NAD-sorbitol dehydrogenase
has related synonym: glucitol dehydrogenase activity
has related synonym: sorbitol dehydrogenase activity
id: GO:0003939
in subset: gosubset prok
type: Class
comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols.
subclass of: GO_0016616

L-iduronidase activity
IAO_0000115: Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate.
has db xref: EC:3.2.1.76
has db xref: MetaCyc:3.2.1.76-RXN
has exact synonym: alpha-L-iduronidase activity
has exact synonym: glycosaminoglycan alpha-L-iduronohydrolase activity
has OBO namespace: molecular_function
id: GO:0003940
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

L-serine ammonia-lyase activity
IAO_0000115: Catalysis of the reaction: L-serine = pyruvate + NH3.
has broad synonym: L-hydroxyaminoacid dehydratase activity
has broad synonym: L-serine dehydratase activity
has broad synonym: serine deaminase activity
has db xref: EC:4.3.1.17
has db xref: MetaCyc:4.3.1.17-RXN
has db xref: RHEA:19172
has exact synonym: L-serine ammonia-lyase (pyruvate-forming) activity
has exact synonym: L-serine deaminase activity
has exact synonym: L-serine hydro-lyase (deaminating) activity
has OBO namespace: molecular_function
id: GO:0003941
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.3.1.13.
subclass of: GO_0016841

N-acetyl-gamma-glutamyl-phosphate reductase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
has broad synonym: NAGSA dehydrogenase activity
has db xref: EC:1.2.1.38
has db xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN
has db xref: RHEA:21591
has exact synonym: N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
has exact synonym: N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
has exact synonym: N-acetyl-glutamate semialdehyde dehydrogenase activity
has exact synonym: N-acetylglutamate 5-semialdehyde dehydrogenase activity
has exact synonym: N-acetylglutamic gamma-semialdehyde dehydrogenase activity
has exact synonym: reductase, acetyl-gamma-glutamyl phosphate
has OBO namespace: molecular_function
id: GO:0003942
in subset: gosubset prok
type: Class
subclass of: GO_0016620

N-acetylgalactosamine-4-sulfatase activity
IAO_0000115: Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.
has broad synonym: chondroitinsulfatase
has db xref: EC:3.1.6.12
has db xref: MetaCyc:3.1.6.12-RXN
has db xref: Wikipedia:Arylsulfatase_B
has exact synonym: N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity
has exact synonym: N-acetylgalactosamine 4-sulfate sulfohydrolase activity
has exact synonym: N-acetylgalactosamine-4-sulphatase activity
has exact synonym: acetylgalactosamine 4-sulfatase activity
has exact synonym: arylsulfatase B
has OBO namespace: molecular_function
id: GO:0003943
in subset: gosubset prok
type: Class
subclass of: GO_0008484

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
IAO_0000115: Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.
has db xref: EC:3.1.4.45
has db xref: MetaCyc:3.1.4.45-RXN
has exact synonym: 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity
has exact synonym: alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity
has exact synonym: alpha-N-acetylglucosaminyl phosphodiesterase activity
has exact synonym: glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity
has exact synonym: phosphodiester glycosidase activity
has narrow synonym: lysosomal alpha-N-acetylglucosaminidase activity
has OBO namespace: molecular_function
id: GO:0003944
type: Class
subclass of: GO_0015929

N-acetyllactosamine synthase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
has db xref: EC:2.4.1.90
has db xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN
has db xref: RHEA:17748
has exact synonym: N-acetylglucosamine (beta-1,4)galactosyltransferase activity
has exact synonym: N-acetylglucosamine beta-(1,4)-galactosyltransferase activity
has exact synonym: N-acetyllactosamine synthetase activity
has exact synonym: NAL synthetase activity
has exact synonym: UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity
has exact synonym: UDP-beta-1,4-galactosyltransferase activity
has exact synonym: UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity
has exact synonym: UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity
has exact synonym: UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity
has exact synonym: UDP-galactose-N-acetylglucosamine galactosyltransferase activity
has exact synonym: UDP-galactose-acetylglucosamine galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity
has exact synonym: UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity
has exact synonym: UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
has exact synonym: UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity
has exact synonym: acetyllactosamine synthetase activity
has exact synonym: beta-(1,4)-galactosyltransferase activity
has exact synonym: beta-1,4-galactosyltransferase activity
has exact synonym: beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity
has exact synonym: lactosamine synthase activity
has exact synonym: lactosamine synthetase activity
has exact synonym: uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity
has OBO namespace: molecular_function
has related synonym: Gal-T
has related synonym: beta-1,4-GalT
has related synonym: lactose synthetase A protein
id: GO:0003945
in subset: gosubset prok
type: Class
subclass of: GO_0035250

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.
has db xref: EC:2.4.1.92
has db xref: MetaCyc:2.4.1.92-RXN
has db xref: RHEA:12591
has exact synonym: GM2 synthase activity
has exact synonym: GM2/GD2-synthase activity
has exact synonym: GalNAc-T activity
has exact synonym: UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity
has exact synonym: asialo-GM2 synthase activity
has exact synonym: beta-1,4N-aetylgalactosaminyltransferase activity
has exact synonym: ganglioside GM2 synthase activity
has exact synonym: ganglioside GM3 acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity
has OBO namespace: molecular_function
id: GO:0003947
type: Class
subclass of: GO_0008376

N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
IAO_0000115: Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).
has db xref: EC:3.5.1.26
has db xref: KEGG:R03421
has db xref: MetaCyc:3.5.1.26-RXN
has db xref: RHEA:11547
has exact synonym: 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
has exact synonym: N-aspartyl-beta-glucosaminidase activity
has exact synonym: N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
has exact synonym: aspartylglucosaminidase activity
has exact synonym: aspartylglucosylaminase activity
has exact synonym: aspartylglucosylamine deaspartylase activity
has exact synonym: aspartylglucosylaminidase activity
has exact synonym: aspartylglycosylamine amidohydrolase activity
has exact synonym: beta-aspartylglucosylamine amidohydrolase activity
has exact synonym: glycosylasparaginase activity
has OBO namespace: molecular_function
has related synonym: glucosylamidase activity
id: GO:0003948
in subset: gosubset prok
type: Class
subclass of: GO_0016811

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
IAO_0000115: Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
has db xref: EC:5.3.1.16
has db xref: KEGG:R04640
has db xref: MetaCyc:PRIBFAICARPISOM-RXN
has db xref: RHEA:15472
has exact synonym: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity
has exact synonym: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity
has exact synonym: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity
has exact synonym: N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity
has exact synonym: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity
has exact synonym: phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity
has OBO namespace: molecular_function
id: GO:0003949
in subset: gosubset prok
type: Class
subclass of: GO_0016861

NAD+ ADP-ribosyltransferase activity
IAO_0000115: Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
has db xref: EC:2.4.2.30
has db xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN
has exact synonym: ADP-ribosyltransferase (polymerizing) activity
has exact synonym: NAD ADP-ribosyltransferase activity
has exact synonym: NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity
has exact synonym: poly(ADP-ribose) synthase activity
has exact synonym: poly(ADP-ribose) synthetase activity
has exact synonym: poly(ADP-ribose)polymerase activity
has exact synonym: poly(adenosine diphosphate ribose) polymerase activity
has OBO namespace: molecular_function
id: GO:0003950
in subset: gosubset prok
type: Class
subclass of: GO_0016763

NAD+ kinase activity
IAO_0000115: Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+).
has db xref: EC:2.7.1.23
has db xref: KEGG:R00104
has db xref: MetaCyc:NAD-KIN-RXN
has db xref: RHEA:18632
has db xref: Reactome:REACT_100710
has db xref: Reactome:REACT_102495
has db xref: Reactome:REACT_104124
has db xref: Reactome:REACT_105015
has db xref: Reactome:REACT_106084
has db xref: Reactome:REACT_106904
has db xref: Reactome:REACT_11234
has db xref: Reactome:REACT_28799
has db xref: Reactome:REACT_30450
has db xref: Reactome:REACT_32843
has db xref: Reactome:REACT_82142
has db xref: Reactome:REACT_86304
has db xref: Reactome:REACT_88716
has db xref: Reactome:REACT_93050
has db xref: Reactome:REACT_94691
has exact synonym: ATP:NAD+ 2'-phosphotransferase activity
has exact synonym: NAD kinase activity
has exact synonym: nicotinamide adenine dinucleotide kinase (phosphorylating)
has exact synonym: nicotinamide adenine dinucleotide kinase activity
has OBO namespace: molecular_function
has related synonym: DPN kinase activity
has related synonym: NADK
id: GO:0003951
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

NAD+ synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.
has db xref: EC:6.3.5.1
has db xref: MetaCyc:NAD-SYNTH-GLN-RXN
has db xref: RHEA:24387
has db xref: Reactome:REACT_101777
has db xref: Reactome:REACT_106358
has db xref: Reactome:REACT_11135
has db xref: Reactome:REACT_112596
has db xref: Reactome:REACT_33314
has db xref: Reactome:REACT_34274
has db xref: Reactome:REACT_34563
has db xref: Reactome:REACT_78384
has db xref: Reactome:REACT_79027
has db xref: Reactome:REACT_80179
has db xref: Reactome:REACT_81822
has db xref: Reactome:REACT_84016
has db xref: Reactome:REACT_86176
has db xref: Reactome:REACT_86976
has db xref: Reactome:REACT_90083
has db xref: Reactome:REACT_90698
has db xref: Reactome:REACT_93162
has db xref: Reactome:REACT_98272
has db xref: Reactome:REACT_98584
has db xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing)
has exact synonym: DPN synthetase activity
has exact synonym: NAD synthase (glutamine-hydrolyzing) activity
has exact synonym: NAD synthetase (glutamine-hydrolysing)
has exact synonym: NAD(+) synthetase (glutamine-hydrolyzing) activity
has exact synonym: NAD+ synthase (glutamine-hydrolysing)
has exact synonym: NAD+ synthetase (glutamine-hydrolyzing)
has exact synonym: deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
has exact synonym: desamidonicotinamide adenine dinucleotide amidotransferase activity
has exact synonym: nicotinamide adenine dinucleotide synthetase (glutamine) activity
has OBO namespace: molecular_function
id: GO:0003952
in subset: gosubset prok
type: Class
subclass of: GO_0016884

NAD+ nucleosidase activity
IAO_0000115: Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.
has db xref: EC:3.2.2.5
has db xref: MetaCyc:NADNUCLEOSID-RXN
has db xref: RHEA:16304
has exact synonym: DPN hydrolase activity
has exact synonym: DPNase activity
has exact synonym: NAD glycohydrolase activity
has exact synonym: NAD hydrolase activity
has exact synonym: NAD nucleosidase activity
has exact synonym: NAD+ glycohydrolase activity
has exact synonym: NADase activity
has exact synonym: diphosphopyridine nucleosidase activity
has exact synonym: nicotinamide adenine dinucleotide glycohydrolase activity
has exact synonym: nicotinamide adenine dinucleotide nucleosidase activity
has OBO namespace: molecular_function
has related synonym: ADP-ribosyl cyclase activity
id: GO:0003953
in subset: gosubset prok
type: Class
subclass of: GO_0016799

NADH dehydrogenase activity
IAO_0000115: Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
has broad synonym: diaphorase activity
has db xref: EC:1.6.99.3
has db xref: MetaCyc:NADH-DEHYDROGENASE-RXN
has db xref: RHEA:11359
has exact synonym: DPNH diaphorase activity
has exact synonym: NADH diaphorase activity
has exact synonym: NADH hydrogenase activity
has exact synonym: NADH oxidoreductase activity
has exact synonym: NADH2 dehydrogenase activity
has exact synonym: NADH:(acceptor) oxidoreductase activity
has exact synonym: NADH:acceptor oxidoreductase activity
has exact synonym: beta-NADH dehydrogenase dinucleotide activity
has exact synonym: dihydrocodehydrogenase I dehydrogenase activity
has exact synonym: dihydronicotinamide adenine dinucleotide dehydrogenase activity
has exact synonym: diphosphopyridine diaphorase activity
has exact synonym: diphosphopyrinase activity
has exact synonym: reduced diphosphopyridine nucleotide diaphorase activity
has narrow synonym: NADH-menadione oxidoreductase activity
has narrow synonym: NADH:cytochrome c oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: cytochrome c reductase activity
has related synonym: type 1 dehydrogenase activity
has related synonym: type I dehydrogenase activity
id: GO:0003954
in subset: gosubset prok
type: Class
subclass of: GO_0016651

NAD(P)H dehydrogenase (quinone) activity
IAO_0000115: Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.
has broad synonym: NAD(P)H menadione reductase activity
has broad synonym: NAD(P)H: menadione oxidoreductase activity
has broad synonym: azoreductase activity
has broad synonym: diaphorase activity
has db xref: EC:1.6.5.2
has db xref: MetaCyc:NQOR-RXN
has db xref: UM-BBD_reactionID:r0227
has exact synonym: DT-diaphorase activity
has exact synonym: NAD(P)H dehydrogenase activity
has exact synonym: NAD(P)H(2) dehydrogenase (quinone) activity
has exact synonym: NAD(P)H-quinone dehydrogenase activity
has exact synonym: NAD(P)H-quinone oxidoreductase activity
has exact synonym: NAD(P)H2 dehydrogenase (quinone)
has exact synonym: NAD(P)H:(quinone-acceptor)oxidoreductase activity
has exact synonym: NAD(P)H:quinone oxidoreductase activity
has exact synonym: dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity
has exact synonym: flavoprotein NAD(P)H-quinone reductase activity
has exact synonym: naphthoquinone reductase activity
has exact synonym: quinone reductase activity
has exact synonym: reduced NAD(P)H dehydrogenase activity
has exact synonym: reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity
has narrow synonym: NADH-menadione reductase activity
has narrow synonym: Naphthoquinone reductase activity
has narrow synonym: menadione oxidoreductase activity
has narrow synonym: menadione reductase activity
has narrow synonym: p-benzoquinone reductase activity
has narrow synonym: phylloquinone reductase activity
has narrow synonym: viologen accepting pyridine nucleotide oxidoreductase activity
has narrow synonym: vitamin K reductase activity
has narrow synonym: vitamin-K reductase activity
has OBO namespace: molecular_function
has related synonym: NQO1
has related synonym: QR1
id: GO:0003955
in subset: gosubset prok
type: Class
subclass of: GO_0016655

NAD(P)+-protein-arginine ADP-ribosyltransferase activity
IAO_0000115: Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.
has broad synonym: ADP-ribosyltransferase activity
has broad synonym: mono(ADP-ribosyl)transferase activity
has broad synonym: mono(ADPribosyl)transferase activity
has db xref: EC:2.4.2.31
has db xref: MetaCyc:2.4.2.31-RXN
has exact synonym: NAD(+):L-arginine ADP-D-ribosyltransferase activity
has exact synonym: NAD(P)(+)--arginine ADP-ribosyltransferase activity
has exact synonym: NAD(P)+-arginine ADP-ribosyltransferase activity
has exact synonym: NAD(P)+:L-arginine ADP-D-ribosyltransferase activity
has exact synonym: NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity
has exact synonym: NAD(P)-arginine ADP-ribosyltransferase activity
has exact synonym: NAD+:L-arginine ADP-D-ribosyltransferase activity
has exact synonym: peptidyl-arginine ADP-ribosylation activity
has exact synonym: protein-arginine ADP-ribosyltransferase activity
has OBO namespace: molecular_function
id: GO:0003956
type: Class
subclass of: GO_0016763

NAD(P)+ transhydrogenase (B-specific) activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
has broad synonym: H+-thase
has broad synonym: NAD transhydrogenase
has broad synonym: NADH transhydrogenase
has broad synonym: NADH-NADP-transhydrogenase
has broad synonym: NADPH-NAD oxidoreductase
has broad synonym: NADPH-NAD transhydrogenase
has broad synonym: NADPH:NAD+ transhydrogenase
has broad synonym: nicotinamide adenine dinucleotide (phosphate) transhydrogenase
has broad synonym: nicotinamide nucleotide transhydrogenase activity
has broad synonym: pyridine nucleotide transferase
has broad synonym: pyridine nucleotide transhydrogenase activity
has db xref: EC:1.6.1.1
has db xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN
has db xref: RHEA:11695
has exact synonym: NAD(P) transhydrogenase (B-specific) activity
has exact synonym: NADPH:NAD+ oxidoreductase (B-specific)
has exact synonym: non-energy-linked transhydrogenase activity
has OBO namespace: molecular_function
id: GO:0003957
in subset: gosubset prok
type: Class
subclass of: GO_0008746
subclass of: GO_0015078

NADPH-hemoprotein reductase activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
has db xref: EC:1.6.2.4
has db xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
has exact synonym: NADPH-cytochrome P-450 oxidoreductase activity
has exact synonym: NADPH-cytochrome p-450 reductase activity
has exact synonym: NADPH-ferrihemoprotein reductase activity
has exact synonym: NADPH:P-450 reductase activity
has exact synonym: NADPH:cytochrome P450 reductase activity
has exact synonym: NADPH:cytochrome c reductase activity
has exact synonym: NADPH:ferrihemoprotein oxidoreductase activity
has exact synonym: NADPH:hemoprotein oxidoreductase activity
has exact synonym: TPNH2 cytochrome c reductase activity
has exact synonym: cytochrome P-450 reductase activity
has narrow synonym: NADP--cytochrome c reductase activity
has narrow synonym: NADP--cytochrome reductase activity
has narrow synonym: NADPH--cytochrome P450 oxidoreductase activity
has narrow synonym: NADPH--cytochrome P450 reductase activity
has narrow synonym: NADPH--cytochrome c oxidoreductase activity
has narrow synonym: NADPH--cytochrome c reductase activity
has narrow synonym: NADPH--ferricytochrome c oxidoreductase activity
has narrow synonym: NADPH--ferrihemoprotein reductase activity
has narrow synonym: NADPH-dependent cytochrome c reductase activity
has narrow synonym: NADPH:P450 reductase activity
has narrow synonym: TPNH(2) cytochrome c reductase activity
has narrow synonym: TPNH-cytochrome c reductase activity
has narrow synonym: cytochrome P450 reductase activity
has narrow synonym: cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
has narrow synonym: dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
has narrow synonym: reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
has narrow synonym: reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
has OBO namespace: molecular_function
has related synonym: CPR activity
has related synonym: FAD-cytochrome c reductase activity
has related synonym: POR
has related synonym: aldehyde reductase (NADPH-dependent) activity
has related synonym: ferrihemoprotein P-450 reductase activity
id: GO:0003958
in subset: gosubset prok
type: Class
subclass of: GO_0016653

NADPH dehydrogenase activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone.
has alternative id: GO:0008468
has alternative id: GO:0016660
has db xref: EC:1.6.99.1
has db xref: MetaCyc:NADPH-DEHYDROGENASE-RXN
has db xref: UM-BBD_enzymeID:e0523
has exact synonym: NADPH diaphorase activity
has exact synonym: NADPH-dehydrogenase activity
has exact synonym: NADPH2 diaphorase activity
has exact synonym: NADPH2-dehydrogenase activity
has exact synonym: NADPH:(acceptor) oxidoreductase activity
has exact synonym: NADPH:acceptor oxidoreductase activity
has exact synonym: TPNH dehydrogenase activity
has exact synonym: TPNH-diaphorase activity
has exact synonym: dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity
has exact synonym: reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity
has exact synonym: triphosphopyridine diaphorase activity
has exact synonym: triphosphopyridine nucleotide diaphorase activity
has OBO namespace: molecular_function
has related synonym: OYE
has related synonym: old yellow enzyme
id: GO:0003959
in subset: gosubset prok
type: Class
subclass of: GO_0016651

NADPH:quinone reductase activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.
has broad synonym: quinone oxidoreductase activity
has db xref: EC:1.6.5.5
has db xref: MetaCyc:QOR-RXN
has exact synonym: NADPH:quinone oxidoreductase activity
has narrow synonym: zeta-crystallin activity
has OBO namespace: molecular_function
id: GO:0003960
in subset: gosubset prok
type: Class
subclass of: GO_0016655

O-acetylhomoserine aminocarboxypropyltransferase activity
IAO_0000115: Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.
has alternative id: GO:0019282
has db xref: EC:2.5.1.49
has db xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN
has db xref: RHEA:10051
has exact synonym: L-methionine anabolism, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine formation, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine synthesis, direct, from O-acetyl-L-homoserine
has exact synonym: O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity
has exact synonym: O-acetyl-L-homoserine sulfhydrolase activity
has exact synonym: O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity
has exact synonym: O-acetylhomoserine (thiol)-lyase activity
has exact synonym: O-acetylhomoserine sulfhydrolase activity
has exact synonym: OAH sulfhydrylase activity
has exact synonym: methionine biosynthetic process, direct, from O-acetyl-L-homoserine
has OBO namespace: molecular_function
has related synonym: 4.2.99.9
id: GO:0003961
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.2.99.10.
subclass of: GO_0016765

cystathionine gamma-synthase activity
IAO_0000115: Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.
has alternative id: GO:0000505
has broad synonym: homoserine O-transsuccinylase activity
has broad synonym: homoserine transsuccinylase activity
has db xref: EC:2.5.1.48
has db xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN
has db xref: RHEA:20400
has exact synonym: CTT gamma synthase activity
has exact synonym: O-succinyl-L-homoserine (thiol)-lyase activity
has exact synonym: O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity
has exact synonym: O-succinyl-L-homoserine succinate-lyase activity
has exact synonym: O-succinylhomoserine (thiol)-lyase activity
has exact synonym: O-succinylhomoserine synthase activity
has exact synonym: O-succinylhomoserine synthetase activity
has exact synonym: O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity
has exact synonym: cystathionine g-synthase activity
has exact synonym: cystathionine gamma synthase activity
has exact synonym: cystathionine synthase activity
has exact synonym: cystathionine synthetase activity
has OBO namespace: molecular_function
id: GO:0003962
in subset: gosubset prok
type: Class
comment: Formerly EC 4.2.99.9.
subclass of: GO_0016765

RNA-3'-phosphate cyclase activity
IAO_0000115: Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.
has db xref: EC:6.5.1.4
has db xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN
has exact synonym: RNA 3'-terminal phosphate cyclase activity
has exact synonym: RNA cyclase activity
has exact synonym: RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)
has OBO namespace: molecular_function
id: GO:0003963
in subset: gosubset prok
type: Class
subclass of: GO_0009975
subclass of: GO_0016886

RNA-directed DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
has db xref: EC:2.7.7.49
has db xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN
has db xref: Reactome:REACT_9039
has db xref: Reactome:REACT_9049
has exact synonym: DNA nucleotidyltransferase (RNA-directed) activity
has exact synonym: RNA revertase activity
has exact synonym: RNA-dependent DNA polymerase activity
has exact synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase activity
has exact synonym: RNA-instructed DNA polymerase activity
has exact synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
has exact synonym: reverse transcriptase activity
has narrow synonym: RNA-directed DNA polymerase, group II intron encoded
has narrow synonym: RNA-directed DNA polymerase, transposon encoded
has OBO namespace: molecular_function
has related synonym: RT
has related synonym: revertase activity
id: GO:0003964
in subset: gosubset prok
type: Class
subclass of: GO_0034061

RNA-directed DNA polymerase, transposon encoded
IAO_0000115: OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.
IAO_0100001: GO:0003964
has OBO namespace: molecular_function
id: GO:0003966
type: Class
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
deprecated: true

RNA-directed DNA polymerase, group II intron encoded
IAO_0000115: OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.
IAO_0100001: GO:0003964
has OBO namespace: molecular_function
id: GO:0003967
type: Class
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
deprecated: true

RNA-directed RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template.
has broad synonym: transcriptase
has db xref: EC:2.7.7.48
has db xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN
has db xref: Reactome:REACT_6210
has db xref: Reactome:REACT_6239
has db xref: Reactome:REACT_6264
has db xref: Reactome:REACT_9404
has db xref: Reactome:REACT_9438
has db xref: Reactome:REACT_9487
has db xref: Reactome:REACT_9513
has exact synonym: 3D polymerase activity
has exact synonym: Q-beta replicase activity
has exact synonym: RNA nucleotidyltransferase (RNA-directed) activity
has exact synonym: RNA replicase activity
has exact synonym: RNA-dependent RNA polymerase activity
has exact synonym: RNA-dependent RNA replicase activity
has exact synonym: RNA-dependent ribonucleate nucleotidyltransferase activity
has exact synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
has exact synonym: ribonucleic acid replicase activity
has exact synonym: ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity
has exact synonym: ribonucleic acid-dependent ribonucleic acid polymerase activity
has exact synonym: ribonucleic replicase activity
has narrow synonym: phage f2 replicase
has OBO namespace: molecular_function
has related synonym: PB1 proteins
has related synonym: PB2 proteins
has related synonym: RDRP
has related synonym: RNA synthetase activity
has related synonym: polymerase L
has related synonym: ribonucleic synthetase activity
id: GO:0003968
in subset: gosubset prok
type: Class
subclass of: GO_0034062

RNA editase activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
has OBO namespace: molecular_function
id: GO:0003969
type: Class
comment: This term was made obsolete because it describes a biological process.
deprecated: true

RNA ligase (ATP) activity
IAO_0000115: Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).
has broad synonym: ribonucleic ligase activity
has db xref: EC:6.5.1.3
has db xref: MetaCyc:RNA-LIGASE-ATP-RXN
has exact synonym: poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)
has exact synonym: polyribonucleotide ligase activity
has exact synonym: polyribonucleotide synthase (ATP) activity
has OBO namespace: molecular_function
id: GO:0003972
in subset: gosubset prok
type: Class
subclass of: GO_0008452

(S)-2-hydroxy-acid oxidase activity
IAO_0000115: Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.
has db xref: EC:1.1.3.15
has db xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN
has exact synonym: (S)-2-hydroxy-acid:oxygen 2-oxidoreductase
has exact synonym: L-2-hydroxy acid oxidase
has exact synonym: L-alpha-hydroxy acid oxidase
has exact synonym: oxidase, L-2-hydroxy acid
has narrow synonym: hydroxy-acid oxidase A activity
has narrow synonym: hydroxy-acid oxidase B activity
has OBO namespace: molecular_function
has related synonym: hydroxyacid oxidase A
id: GO:0003973
in subset: gosubset prok
type: Class
subclass of: GO_0016899

UDP-N-acetylglucosamine 4-epimerase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.
has db xref: EC:5.1.3.7
has db xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN
has db xref: RHEA:20520
has exact synonym: UDP acetylglucosamine epimerase activity
has exact synonym: UDP-GlcNAc 4-epimerase activity
has exact synonym: UDP-N-acetyl-D-glucosamine 4-epimerase activity
has exact synonym: uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity
has exact synonym: uridine diphosphate N-acetylglucosamine-4-epimerase activity
has exact synonym: uridine diphosphoacetylglucosamine epimerase activity
has OBO namespace: molecular_function
id: GO:0003974
in subset: gosubset prok
type: Class
subclass of: GO_0016857

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
has db xref: EC:2.7.8.15
has db xref: MetaCyc:2.7.8.15-RXN
has db xref: RHEA:13292
has db xref: Reactome:REACT_22147
has exact synonym: GlcNAc-1-P transferase activity
has exact synonym: N-acetylglucosamine-1-phosphate transferase activity
has exact synonym: UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity
has exact synonym: UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity
has exact synonym: UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity
has exact synonym: UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity
has exact synonym: chitobiosylpyrophosphoryldolichol synthase activity
has exact synonym: dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity
has OBO namespace: molecular_function
id: GO:0003975
in subset: gosubset prok
type: Class
subclass of: GO_0016780

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.
has db xref: EC:2.7.8.17
has db xref: MetaCyc:2.7.8.17-RXN
has exact synonym: N-acetylglucosaminyl phosphotransferase activity
has exact synonym: UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity
has OBO namespace: molecular_function
has related synonym: N-acetylglucosaminylphosphotransferase activity
id: GO:0003976
type: Class
subclass of: GO_0016780

UDP-N-acetylglucosamine diphosphorylase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.
has broad synonym: acetylglucosamine 1-phosphate uridylyltransferase
has db xref: EC:2.7.7.23
has db xref: KEGG:R00416
has db xref: MetaCyc:NAG1P-URIDYLTRANS-RXN
has db xref: RHEA:13512
has db xref: Reactome:REACT_22397
has exact synonym: GlmU uridylyltransferase activity
has exact synonym: N-acetylglucosamine-1-phosphate uridyltransferase activity
has exact synonym: UDP-GlcNAc pyrophosphorylase activity
has exact synonym: UDP-N-acetylglucosamine pyrophosphorylase activity
has exact synonym: UDP-acetylglucosamine pyrophosphorylase activity
has exact synonym: UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity
has exact synonym: UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity
has exact synonym: uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity
has exact synonym: uridine diphosphoacetylglucosamine phosphorylase activity
has exact synonym: uridine diphosphoacetylglucosamine pyrophosphorylase activity
has OBO namespace: molecular_function
id: GO:0003977
in subset: gosubset prok
type: Class
subclass of: GO_0070569

UDP-glucose 4-epimerase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose = UDP-galactose.
has db xref: EC:5.1.3.2
has db xref: MetaCyc:UDPGLUCEPIM-RXN
has db xref: RHEA:22171
has db xref: Reactome:REACT_102168
has db xref: Reactome:REACT_115000
has db xref: Reactome:REACT_115332
has db xref: Reactome:REACT_115411
has db xref: Reactome:REACT_1315
has db xref: Reactome:REACT_31550
has db xref: Reactome:REACT_33528
has db xref: Reactome:REACT_34575
has db xref: Reactome:REACT_78749
has db xref: Reactome:REACT_78984
has db xref: Reactome:REACT_83662
has db xref: Reactome:REACT_84187
has db xref: Reactome:REACT_87173
has db xref: Reactome:REACT_87677
has db xref: Reactome:REACT_90321
has db xref: Reactome:REACT_91321
has db xref: Reactome:REACT_94034
has db xref: Reactome:REACT_97325
has exact synonym: 4-epimerase activity
has exact synonym: UDP-D-galactose 4-epimerase activity
has exact synonym: UDP-galactose 4-epimerase activity
has exact synonym: UDP-glucose epimerase activity
has exact synonym: UDPG-4-epimerase activity
has exact synonym: UDPgalactose 4-epimerase activity
has exact synonym: UDPglucose 4-epimerase activity
has exact synonym: uridine diphosphate galactose 4-epimerase activity
has exact synonym: uridine diphosphate glucose 4-epimerase activity
has exact synonym: uridine diphospho-galactose-4-epimerase activity
has exact synonym: uridine diphosphoglucose 4-epimerase activity
has exact synonym: uridine diphosphoglucose epimerase activity
has OBO namespace: molecular_function
has related synonym: galactowaldenase activity
id: GO:0003978
in subset: gosubset prok
type: Class
subclass of: GO_0016857

UDP-glucose 6-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.
has db xref: EC:1.1.1.22
has db xref: KEGG:R00286
has db xref: MetaCyc:UGD-RXN
has db xref: RHEA:23599
has db xref: Reactome:REACT_101674
has db xref: Reactome:REACT_102401
has db xref: Reactome:REACT_103324
has db xref: Reactome:REACT_104028
has db xref: Reactome:REACT_106090
has db xref: Reactome:REACT_112524
has db xref: Reactome:REACT_28362
has db xref: Reactome:REACT_30359
has db xref: Reactome:REACT_32524
has db xref: Reactome:REACT_6876
has db xref: Reactome:REACT_82981
has db xref: Reactome:REACT_90704
has db xref: Reactome:REACT_90852
has db xref: Reactome:REACT_93404
has db xref: Reactome:REACT_98306
has db xref: Reactome:REACT_98484
has OBO namespace: molecular_function
id: GO:0003979
in subset: gosubset prok
type: Class
subclass of: GO_0016616

UDP-glucose:glycoprotein glucosyltransferase activity
IAO_0000115: Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.
has db xref: EC:2.4.1.-
has db xref: Reactome:REACT_25264
has exact synonym: UGGT activity
has OBO namespace: molecular_function
id: GO:0003980
type: Class
subclass of: GO_0035251

UTP:glucose-1-phosphate uridylyltransferase activity
IAO_0000115: Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.
has db xref: EC:2.7.7.9
has db xref: KEGG:R00289
has db xref: MetaCyc:GLUC1PURIDYLTRANS-RXN
has db xref: RHEA:19892
has db xref: Reactome:REACT_101085
has db xref: Reactome:REACT_101096
has db xref: Reactome:REACT_103410
has db xref: Reactome:REACT_103497
has db xref: Reactome:REACT_104734
has db xref: Reactome:REACT_105080
has db xref: Reactome:REACT_110476
has db xref: Reactome:REACT_82849
has db xref: Reactome:REACT_84996
has db xref: Reactome:REACT_85597
has db xref: Reactome:REACT_86
has db xref: Reactome:REACT_87986
has db xref: Reactome:REACT_90031
has db xref: Reactome:REACT_91019
has db xref: Reactome:REACT_94840
has db xref: Reactome:REACT_95999
has db xref: Reactome:REACT_98501
has exact synonym: UDP glucose pyrophosphorylase activity
has exact synonym: UDP-glucose diphosphorylase activity
has exact synonym: UDP-glucose pyrophosphorylase activity
has exact synonym: UDPG phosphorylase activity
has exact synonym: UDPG pyrophosphorylase activity
has exact synonym: UTP-glucose-1-phosphate uridylyltransferase activity
has exact synonym: UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity
has exact synonym: glucose-1-phosphate uridylyltransferase activity
has exact synonym: uridine 5'-diphosphoglucose pyrophosphorylase activity
has exact synonym: uridine diphosphate-D-glucose pyrophosphorylase activity
has exact synonym: uridine diphosphoglucose pyrophosphorylase activity
has exact synonym: uridine-diphosphate glucose pyrophosphorylase activity
has OBO namespace: molecular_function
id: GO:0003983
in subset: gosubset prok
type: Class
subclass of: GO_0051748

acetolactate synthase activity
IAO_0000115: Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
has db xref: EC:2.2.1.6
has db xref: MetaCyc:ACETOLACTSYN-RXN
has db xref: RHEA:20504
has exact synonym: acetohydroxy acid synthetase activity
has exact synonym: acetohydroxyacid synthase activity
has exact synonym: acetolactate pyruvate-lyase (carboxylating) activity
has exact synonym: acetolactic synthetase activity
has exact synonym: alpha-acetohydroxy acid synthetase activity
has exact synonym: alpha-acetohydroxyacid synthase activity
has exact synonym: alpha-acetolactate synthase activity
has exact synonym: alpha-acetolactate synthetase activity
has exact synonym: pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
has OBO namespace: molecular_function
id: GO:0003984
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.3.18.
subclass of: GO_0016744

acetyl-CoA C-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
has broad synonym: 2-methylacetoacetyl-CoA thiolase
has db xref: EC:2.3.1.9
has db xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN
has db xref: RHEA:21039
has db xref: Reactome:REACT_100461
has db xref: Reactome:REACT_102319
has db xref: Reactome:REACT_102321
has db xref: Reactome:REACT_102563
has db xref: Reactome:REACT_102876
has db xref: Reactome:REACT_103568
has db xref: Reactome:REACT_103940
has db xref: Reactome:REACT_104958
has db xref: Reactome:REACT_105003
has db xref: Reactome:REACT_105426
has db xref: Reactome:REACT_105877
has db xref: Reactome:REACT_106542
has db xref: Reactome:REACT_109820
has db xref: Reactome:REACT_109899
has db xref: Reactome:REACT_112932
has db xref: Reactome:REACT_113533
has db xref: Reactome:REACT_114812
has db xref: Reactome:REACT_1478
has db xref: Reactome:REACT_28462
has db xref: Reactome:REACT_28526
has db xref: Reactome:REACT_28646
has db xref: Reactome:REACT_31277
has db xref: Reactome:REACT_31739
has db xref: Reactome:REACT_31976
has db xref: Reactome:REACT_32156
has db xref: Reactome:REACT_47
has db xref: Reactome:REACT_79103
has db xref: Reactome:REACT_79150
has db xref: Reactome:REACT_80792
has db xref: Reactome:REACT_81504
has db xref: Reactome:REACT_82257
has db xref: Reactome:REACT_83250
has db xref: Reactome:REACT_83764
has db xref: Reactome:REACT_84180
has db xref: Reactome:REACT_84285
has db xref: Reactome:REACT_85056
has db xref: Reactome:REACT_85622
has db xref: Reactome:REACT_86508
has db xref: Reactome:REACT_88187
has db xref: Reactome:REACT_884
has db xref: Reactome:REACT_92663
has db xref: Reactome:REACT_92854
has db xref: Reactome:REACT_93534
has db xref: Reactome:REACT_93658
has db xref: Reactome:REACT_93946
has db xref: Reactome:REACT_96819
has db xref: Reactome:REACT_97416
has db xref: Reactome:REACT_97821
has db xref: UM-BBD_enzymeID:e0144
has exact synonym: 3-oxothiolase activity
has exact synonym: acetoacetyl-CoA thiolase activity
has exact synonym: acetyl coenzyme A thiolase activity
has exact synonym: acetyl-CoA acetyltransferase activity
has exact synonym: acetyl-CoA:N-acetyltransferase activity
has exact synonym: acetyl-CoA:acetyl-CoA C-acetyltransferase activity
has exact synonym: beta-acetoacetyl coenzyme A thiolase activity
has OBO namespace: molecular_function
has related synonym: thiolase II
id: GO:0003985
in subset: gosubset prok
type: Class
subclass of: acetyl-CoA C-acyltransferase activity
subclass of: GO_0016453

acetyl-CoA hydrolase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
has db xref: EC:3.1.2.1
has db xref: KEGG:R00227
has db xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN
has db xref: RHEA:20292
has db xref: Reactome:REACT_102494
has db xref: Reactome:REACT_104855
has db xref: Reactome:REACT_105619
has db xref: Reactome:REACT_105926
has db xref: Reactome:REACT_109012
has db xref: Reactome:REACT_109195
has db xref: Reactome:REACT_16974
has db xref: Reactome:REACT_77871
has db xref: Reactome:REACT_83459
has db xref: Reactome:REACT_86591
has db xref: Reactome:REACT_88142
has db xref: Reactome:REACT_89514
has db xref: Reactome:REACT_94225
has db xref: Reactome:REACT_94231
has db xref: Reactome:REACT_98144
has db xref: Reactome:REACT_99433
has exact synonym: acetyl coenzyme A acylase activity
has exact synonym: acetyl coenzyme A deacylase activity
has exact synonym: acetyl coenzyme A hydrolase activity
has exact synonym: acetyl-CoA acylase activity
has exact synonym: acetyl-CoA deacylase activity
has exact synonym: acetyl-CoA thiol esterase activity
has OBO namespace: molecular_function
id: GO:0003986
in subset: gosubset prok
type: Class
subclass of: GO_0016289

acetate-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
has broad synonym: acetate thiokinase activity
has broad synonym: acyl-activating enzyme activity
has db xref: EC:6.2.1.1
has db xref: MetaCyc:ACETATE--COA-LIGASE-RXN
has db xref: RHEA:23179
has db xref: Reactome:REACT_101761
has db xref: Reactome:REACT_102092
has db xref: Reactome:REACT_103963
has db xref: Reactome:REACT_106135
has db xref: Reactome:REACT_107058
has db xref: Reactome:REACT_112167
has db xref: Reactome:REACT_21284
has db xref: Reactome:REACT_30831
has db xref: Reactome:REACT_31444
has db xref: Reactome:REACT_32745
has db xref: Reactome:REACT_553
has db xref: Reactome:REACT_80622
has db xref: Reactome:REACT_84415
has db xref: Reactome:REACT_85826
has db xref: Reactome:REACT_92738
has db xref: Reactome:REACT_96131
has db xref: Reactome:REACT_98155
has exact synonym: acetate:CoA ligase (AMP-forming)
has exact synonym: acetic thiokinase activity
has exact synonym: acetyl CoA ligase activity
has exact synonym: acetyl CoA synthase activity
has exact synonym: acetyl coenzyme A synthetase activity
has exact synonym: acetyl-CoA synthase activity
has exact synonym: acetyl-CoA synthetase activity
has exact synonym: acetyl-activating enzyme activity
has exact synonym: acetyl-coenzyme A synthase activity
has exact synonym: short chain fatty acyl-CoA synthetase activity
has exact synonym: short-chain acyl-coenzyme A synthetase activity
has OBO namespace: molecular_function
has related synonym: ACS
has related synonym: acetate to acetyl-CoA
has related synonym: acetyl activating enzyme
id: GO:0003987
in subset: gosubset prok
type: Class
subclass of: GO_0016405
subclass of: GO_0016878

acetyl-CoA C-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
has broad synonym: 2-methylacetoacetyl-CoA thiolase
has db xref: EC:2.3.1.16
has db xref: MetaCyc:KETOACYLCOATHIOL-RXN
has db xref: RHEA:21567
has db xref: Reactome:REACT_106127
has db xref: Reactome:REACT_106648
has db xref: Reactome:REACT_106889
has db xref: Reactome:REACT_110593
has db xref: Reactome:REACT_16946
has db xref: Reactome:REACT_29227
has db xref: Reactome:REACT_30577
has db xref: Reactome:REACT_79644
has db xref: Reactome:REACT_83687
has db xref: Reactome:REACT_85643
has db xref: Reactome:REACT_87029
has db xref: Reactome:REACT_88222
has db xref: Reactome:REACT_93039
has db xref: Reactome:REACT_94311
has db xref: Reactome:REACT_99914
has db xref: UM-BBD_reactionID:r1051
has exact synonym: 2-keto-acyl thiolase activity
has exact synonym: 3-ketoacyl CoA thiolase activity
has exact synonym: 3-ketoacyl coenzyme A thiolase activity
has exact synonym: 3-ketoacyl thiolase activity
has exact synonym: 3-ketoacyl-CoA thiolase activity
has exact synonym: 3-ketothiolase activity
has exact synonym: 3-oxoacyl-CoA thiolase activity
has exact synonym: 3-oxoacyl-coenzyme A thiolase activity
has exact synonym: 6-oxoacyl-CoA thiolase activity
has exact synonym: acetoacetyl-CoA beta-ketothiolase activity
has exact synonym: acetyl-CoA acyltransferase activity
has exact synonym: acyl-CoA:acetyl-CoA C-acyltransferase activity
has exact synonym: beta-ketoacyl coenzyme A thiolase activity
has exact synonym: beta-ketoacyl-CoA thiolase activity
has exact synonym: beta-ketoadipyl coenzyme A thiolase activity
has exact synonym: beta-ketoadipyl-CoA thiolase activity
has exact synonym: beta-ketothiolase activity
has exact synonym: ketoacyl-CoA acyltransferase activity
has exact synonym: ketoacyl-coenzyme A thiolase activity
has exact synonym: long-chain 3-oxoacyl-CoA thiolase activity
has exact synonym: oxoacyl-coenzyme A thiolase activity
has exact synonym: pro-3-ketoacyl-CoA thiolase activity
has OBO namespace: molecular_function
has related synonym: KAT
has related synonym: thiolase I
id: GO:0003988
in subset: gosubset prok
type: Class
subclass of: GO_0016408

acetyl-CoA carboxylase activity
IAO_0000115: Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
has db xref: EC:6.4.1.2
has db xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN
has db xref: RHEA:11311
has db xref: Reactome:REACT_100526
has db xref: Reactome:REACT_100609
has db xref: Reactome:REACT_103671
has db xref: Reactome:REACT_104374
has db xref: Reactome:REACT_105410
has db xref: Reactome:REACT_109995
has db xref: Reactome:REACT_11201
has db xref: Reactome:REACT_114007
has db xref: Reactome:REACT_28375
has db xref: Reactome:REACT_28966
has db xref: Reactome:REACT_29662
has db xref: Reactome:REACT_30959
has db xref: Reactome:REACT_32583
has db xref: Reactome:REACT_33034
has db xref: Reactome:REACT_34127
has db xref: Reactome:REACT_34284
has db xref: Reactome:REACT_590
has db xref: Reactome:REACT_77884
has db xref: Reactome:REACT_80005
has db xref: Reactome:REACT_81142
has db xref: Reactome:REACT_84058
has db xref: Reactome:REACT_87135
has db xref: Reactome:REACT_88443
has db xref: Reactome:REACT_90395
has db xref: Reactome:REACT_90662
has db xref: Reactome:REACT_92102
has db xref: Reactome:REACT_92269
has db xref: Reactome:REACT_93364
has db xref: Reactome:REACT_95365
has db xref: Reactome:REACT_97953
has db xref: Reactome:REACT_98607
has db xref: Reactome:REACT_99199
has exact synonym: acetyl coenzyme A carboxylase activity
has exact synonym: acetyl-CoA:carbon-dioxide ligase (ADP-forming)
has OBO namespace: molecular_function
id: GO:0003989
in subset: gosubset prok
type: Class
subclass of: GO_0016421

acetylcholinesterase activity
IAO_0000115: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.
has db xref: EC:3.1.1.7
has db xref: MetaCyc:ACETYLCHOLINESTERASE-RXN
has db xref: RHEA:17564
has db xref: Reactome:REACT_109174
has db xref: Reactome:REACT_14816
has db xref: Reactome:REACT_85985
has db xref: Reactome:REACT_89645
has db xref: Reactome:REACT_96859
has db xref: Reactome:REACT_99846
has exact synonym: acetyl.beta-methylcholinesterase activity
has exact synonym: acetylcholine acetylhydrolase activity
has exact synonym: acetylcholine hydrolase activity
has exact synonym: acetylthiocholinesterase activity
has exact synonym: choline esterase I activity
has exact synonym: true cholinesterase activity
has OBO namespace: molecular_function
has related synonym: AcCholE
id: GO:0003990
in subset: gosubset prok
type: Class
subclass of: cholinesterase activity

acetylglutamate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate.
has db xref: EC:2.7.2.8
has db xref: MetaCyc:ACETYLGLUTKIN-RXN
has db xref: RHEA:14632
has exact synonym: ATP:N-acetyl-L-glutamate 5-phosphotransferase activity
has exact synonym: N-acetylglutamate 5-phosphotransferase activity
has exact synonym: N-acetylglutamate kinase activity
has exact synonym: N-acetylglutamate phosphokinase activity
has exact synonym: N-acetylglutamic 5-phosphotransferase activity
has exact synonym: acetylglutamate phosphokinase activity
has OBO namespace: molecular_function
id: GO:0003991
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016774

N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
has alternative id: GO:0047318
has broad synonym: acetylornithine aminotransferase activity
has broad synonym: acetylornithine transaminase activity
has broad synonym: succinylornithine aminotransferase activity
has db xref: EC:2.6.1.11
has db xref: KEGG:R02283
has db xref: MetaCyc:ACETYLORNTRANSAM-RXN
has db xref: RHEA:18052
has exact synonym: 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
has exact synonym: ACOAT activity
has exact synonym: N(2)-acetylornithine 5-transaminase activity
has exact synonym: N-acetylornithine aminotransferase activity
has exact synonym: N-acetylornithine-delta-transaminase activity
has exact synonym: N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity
has exact synonym: N2-acetylornithine 5-aminotransferase activity
has exact synonym: N2-acetylornithine 5-transaminase activity
has exact synonym: acetylornithine 5-aminotransferase activity
has exact synonym: acetylornithine delta-transaminase activity
has OBO namespace: molecular_function
id: GO:0003992
in subset: gosubset prok
type: Class
subclass of: GO_0008483

acid phosphatase activity
IAO_0000115: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
has broad synonym: glycerophosphatase activity
has broad synonym: phosphomonoesterase activity
has db xref: EC:3.1.3.2
has db xref: MetaCyc:ACID-PHOSPHATASE-RXN
has db xref: Reactome:REACT_104847
has db xref: Reactome:REACT_11171
has db xref: Reactome:REACT_80951
has db xref: Reactome:REACT_82194
has db xref: Reactome:REACT_82472
has db xref: Reactome:REACT_83480
has db xref: Reactome:REACT_83568
has db xref: Reactome:REACT_84333
has db xref: Reactome:REACT_97154
has db xref: Reactome:REACT_97735
has db xref: Reactome:REACT_99971
has exact synonym: acid monophosphatase activity
has exact synonym: acid nucleoside diphosphate phosphatase activity
has exact synonym: acid phosphohydrolase activity
has exact synonym: acid phosphomonoester hydrolase activity
has exact synonym: acid phosphomonoesterase activity
has exact synonym: orthophosphoric-monoester phosphohydrolase (acid optimum)
has exact synonym: phosphate-monoester phosphohydrolase (acid optimum)
has OBO namespace: molecular_function
has related synonym: uteroferrin
id: GO:0003993
in subset: gosubset prok
type: Class
subclass of: GO_0016791

aconitate hydratase activity
IAO_0000115: Catalysis of the reactions: citrate = cis-aconitate + H2O, and cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
has broad synonym: citrate hydro-lyase activity
has db xref: EC:4.2.1.3
has db xref: RHEA:10231
has db xref: RHEA:22148
has db xref: Reactome:REACT_106698
has db xref: Reactome:REACT_115701
has db xref: Reactome:REACT_116024
has db xref: Reactome:REACT_1898
has db xref: Reactome:REACT_21262
has db xref: Reactome:REACT_30406
has db xref: Reactome:REACT_32627
has db xref: Reactome:REACT_46526
has db xref: Reactome:REACT_77059
has db xref: Reactome:REACT_77875
has db xref: Reactome:REACT_77983
has db xref: Reactome:REACT_78997
has db xref: Reactome:REACT_81376
has db xref: Reactome:REACT_82548
has db xref: Reactome:REACT_83980
has db xref: Reactome:REACT_86078
has db xref: Reactome:REACT_90644
has db xref: Reactome:REACT_97737
has exact synonym: aconitase activity
has exact synonym: cis-aconitase activity
has exact synonym: citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
has exact synonym: citrate(isocitrate) hydro-lyase activity
has OBO namespace: molecular_function
id: GO:0003994
in subset: gosubset prok
type: Class
comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'.
subclass of: GO_0016836

acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
has alternative id: GO:0019109
has db xref: EC:1.3.99.3
has db xref: MetaCyc:ACYLCOADEHYDROG-RXN
has db xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
has db xref: Reactome:REACT_100103
has db xref: Reactome:REACT_100162
has db xref: Reactome:REACT_100783
has db xref: Reactome:REACT_101760
has db xref: Reactome:REACT_102752
has db xref: Reactome:REACT_102754
has db xref: Reactome:REACT_102759
has db xref: Reactome:REACT_103113
has db xref: Reactome:REACT_103307
has db xref: Reactome:REACT_103703
has db xref: Reactome:REACT_103943
has db xref: Reactome:REACT_105107
has db xref: Reactome:REACT_105146
has db xref: Reactome:REACT_105296
has db xref: Reactome:REACT_105300
has db xref: Reactome:REACT_106191
has db xref: Reactome:REACT_106900
has db xref: Reactome:REACT_107615
has db xref: Reactome:REACT_107729
has db xref: Reactome:REACT_107750
has db xref: Reactome:REACT_108764
has db xref: Reactome:REACT_108765
has db xref: Reactome:REACT_108767
has db xref: Reactome:REACT_108853
has db xref: Reactome:REACT_108930
has db xref: Reactome:REACT_109051
has db xref: Reactome:REACT_109106
has db xref: Reactome:REACT_109954
has db xref: Reactome:REACT_110072
has db xref: Reactome:REACT_110834
has db xref: Reactome:REACT_110858
has db xref: Reactome:REACT_1111
has db xref: Reactome:REACT_113088
has db xref: Reactome:REACT_113123
has db xref: Reactome:REACT_114274
has db xref: Reactome:REACT_1177
has db xref: Reactome:REACT_1285
has db xref: Reactome:REACT_1592
has db xref: Reactome:REACT_1742
has db xref: Reactome:REACT_1862
has db xref: Reactome:REACT_1912
has db xref: Reactome:REACT_2238
has db xref: Reactome:REACT_28111
has db xref: Reactome:REACT_28194
has db xref: Reactome:REACT_28196
has db xref: Reactome:REACT_28454
has db xref: Reactome:REACT_28855
has db xref: Reactome:REACT_30090
has db xref: Reactome:REACT_31237
has db xref: Reactome:REACT_31733
has db xref: Reactome:REACT_31777
has db xref: Reactome:REACT_31820
has db xref: Reactome:REACT_32022
has db xref: Reactome:REACT_32213
has db xref: Reactome:REACT_32236
has db xref: Reactome:REACT_32631
has db xref: Reactome:REACT_32695
has db xref: Reactome:REACT_32711
has db xref: Reactome:REACT_32796
has db xref: Reactome:REACT_33031
has db xref: Reactome:REACT_33392
has db xref: Reactome:REACT_33795
has db xref: Reactome:REACT_34132
has db xref: Reactome:REACT_34359
has db xref: Reactome:REACT_34562
has db xref: Reactome:REACT_398
has db xref: Reactome:REACT_43718
has db xref: Reactome:REACT_440
has db xref: Reactome:REACT_442
has db xref: Reactome:REACT_48070
has db xref: Reactome:REACT_62169
has db xref: Reactome:REACT_630
has db xref: Reactome:REACT_77605
has db xref: Reactome:REACT_77947
has db xref: Reactome:REACT_79468

acyl-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C13 to C22.
has db xref: EC:6.2.1.-
has OBO namespace: molecular_function
id: GO:0003996
in subset: gosubset prok
type: Class
subclass of: GO_0016405
subclass of: GO_0016878

acyl-CoA oxidase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
has db xref: EC:1.3.3.6
has db xref: MetaCyc:ACYL-COA-OXIDASE-RXN
has db xref: Reactome:REACT_10003
has db xref: Reactome:REACT_10074
has db xref: Reactome:REACT_101202
has db xref: Reactome:REACT_102703
has db xref: Reactome:REACT_103315
has db xref: Reactome:REACT_104041
has db xref: Reactome:REACT_105955
has db xref: Reactome:REACT_107417
has db xref: Reactome:REACT_107469
has db xref: Reactome:REACT_109809
has db xref: Reactome:REACT_114247
has db xref: Reactome:REACT_115434
has db xref: Reactome:REACT_17054
has db xref: Reactome:REACT_28592
has db xref: Reactome:REACT_29191
has db xref: Reactome:REACT_30183
has db xref: Reactome:REACT_30256
has db xref: Reactome:REACT_30656
has db xref: Reactome:REACT_33505
has db xref: Reactome:REACT_34639
has db xref: Reactome:REACT_34682
has db xref: Reactome:REACT_78214
has db xref: Reactome:REACT_78286
has db xref: Reactome:REACT_78800
has db xref: Reactome:REACT_80085
has db xref: Reactome:REACT_81057
has db xref: Reactome:REACT_81512
has db xref: Reactome:REACT_86463
has db xref: Reactome:REACT_86667
has db xref: Reactome:REACT_89834
has db xref: Reactome:REACT_90722
has db xref: Reactome:REACT_95380
has db xref: Reactome:REACT_97066
has db xref: Reactome:REACT_97420
has db xref: Reactome:REACT_97865
has db xref: Reactome:REACT_98266
has exact synonym: acyl coenzyme A oxidase activity
has exact synonym: acyl-CoA:oxygen 2-oxidoreductase activity
has exact synonym: fatty acyl-CoA oxidase activity
has exact synonym: fatty acyl-coenzyme A oxidase activity
has OBO namespace: molecular_function
id: GO:0003997
in subset: gosubset prok
type: Class
subclass of: GO_0016634

acylphosphatase activity
IAO_0000115: Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
has db xref: EC:3.6.1.7
has db xref: MetaCyc:ACYLPHOSPHATASE-RXN
has db xref: RHEA:14968
has exact synonym: 1,3-diphosphoglycerate phosphatase activity
has exact synonym: acetic phosphatase activity
has exact synonym: acetylphosphatase activity
has exact synonym: acylphosphate phosphohydrolase activity
has OBO namespace: molecular_function
has related synonym: GP 1-3
has related synonym: Ho 1-3
id: GO:0003998
in subset: gosubset prok
type: Class
subclass of: GO_0016818

adenine phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
has db xref: EC:2.4.2.7
has db xref: MetaCyc:ADENPRIBOSYLTRAN-RXN
has db xref: RHEA:16612
has db xref: Reactome:REACT_101521
has db xref: Reactome:REACT_103283
has db xref: Reactome:REACT_103528
has db xref: Reactome:REACT_104835
has db xref: Reactome:REACT_104879
has db xref: Reactome:REACT_165
has db xref: Reactome:REACT_32070
has db xref: Reactome:REACT_32930
has db xref: Reactome:REACT_79242
has db xref: Reactome:REACT_84269
has db xref: Reactome:REACT_84345
has db xref: Reactome:REACT_85331
has db xref: Reactome:REACT_87474
has db xref: Reactome:REACT_87859
has db xref: Reactome:REACT_88309
has db xref: Reactome:REACT_90224
has db xref: Reactome:REACT_90510
has exact synonym: AMP diphosphorylase activity
has exact synonym: AMP pyrophosphorylase activity
has exact synonym: AMP-pyrophosphate phosphoribosyltransferase activity
has exact synonym: AMP:diphosphate phospho-D-ribosyltransferase activity
has exact synonym: APRT activity
has exact synonym: adenine phosphoribosylpyrophosphate transferase activity
has exact synonym: adenosine phosphoribosyltransferase activity
has exact synonym: adenylate pyrophosphorylase activity
has exact synonym: adenylic pyrophosphorylase activity
has OBO namespace: molecular_function
has related synonym: transphosphoribosidase activity
id: GO:0003999
in subset: gosubset prok
type: Class
subclass of: GO_0016763

adenosine deaminase activity
IAO_0000115: Catalysis of the reaction: adenosine + H2O = inosine + NH3.
has db xref: EC:3.5.4.4
has db xref: MetaCyc:ADENODEAMIN-RXN
has db xref: RHEA:24411
has db xref: Reactome:REACT_107117
has db xref: Reactome:REACT_107659
has db xref: Reactome:REACT_113447
has db xref: Reactome:REACT_114346
has db xref: Reactome:REACT_2135
has db xref: Reactome:REACT_32268
has db xref: Reactome:REACT_34635
has db xref: Reactome:REACT_84913
has db xref: Reactome:REACT_92015
has db xref: Reactome:REACT_93814
has db xref: Reactome:REACT_98610
has exact synonym: adenosine aminohydrolase activity
has exact synonym: adenosine deaminase reaction
has OBO namespace: molecular_function
id: GO:0004000
in subset: gosubset prok
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

adenosine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + adenosine = ADP + AMP.
has db xref: EC:2.7.1.20
has db xref: MetaCyc:ADENOSINE-KINASE-RXN
has db xref: RHEA:20827
has db xref: Reactome:REACT_102294
has db xref: Reactome:REACT_103994
has db xref: Reactome:REACT_110560
has db xref: Reactome:REACT_112074
has db xref: Reactome:REACT_114269
has db xref: Reactome:REACT_1728
has db xref: Reactome:REACT_32035
has db xref: Reactome:REACT_32321
has db xref: Reactome:REACT_33598
has db xref: Reactome:REACT_78205
has db xref: Reactome:REACT_78906
has db xref: Reactome:REACT_80139
has db xref: Reactome:REACT_80336
has db xref: Reactome:REACT_86275
has db xref: Reactome:REACT_95743
has db xref: Reactome:REACT_96492
has exact synonym: ATP:adenosine 5'-phosphotransferase activity
has exact synonym: adenosine 5-phosphotransferase activity
has exact synonym: adenosine kinase (phosphorylating)
has OBO namespace: molecular_function
id: GO:0004001
in subset: gosubset prok
type: Class
subclass of: GO_0019206

ATP-dependent DNA helicase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
has OBO namespace: molecular_function
id: GO:0004003
in subset: gosubset prok
type: Class
subclass of: DNA helicase activity
subclass of: GO_0008026
subclass of: GO_0008094

ATP-dependent RNA helicase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
has db xref: Reactome:REACT_75794
has OBO namespace: molecular_function
id: GO:0004004
in subset: gosubset prok
type: Class
subclass of: RNA helicase activity
subclass of: GO_0008026
subclass of: GO_0008186

plasma membrane cation-transporting ATPase
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0005886
consider: GO:0019829
has OBO namespace: molecular_function
id: GO:0004005
type: Class
comment: This term was made obsolete because it contains both component and function information.
deprecated: true

heavy metal-exporting ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate.
consider: GO:0046873
has OBO namespace: molecular_function
id: GO:0004007
type: Class
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
deprecated: true

copper-exporting ATPase activity
IAO_0000115: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out).
has db xref: EC:3.6.3.4
has db xref: MetaCyc:3.6.3.4-RXN
has db xref: RHEA:10379
has db xref: Reactome:REACT_25071
has exact synonym: ATP phosphohydrolase (Cu2+-exporting)
has exact synonym: Cu(2+)-exporting ATPase activity
has exact synonym: Cu2+-exporting ATPase activity
has exact synonym: copper exporting ATPase activity
has OBO namespace: molecular_function
has related synonym: copper-translocating P-type ATPase activity
id: GO:0004008
in subset: gosubset prok
type: Class
subclass of: GO_0043682

ATP-binding cassette (ABC) transporter activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0042626
consider: GO:0043190
has OBO namespace: molecular_function
id: GO:0004009
type: Class
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
deprecated: true

phospholipid-translocating ATPase activity
IAO_0000115: Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
has alternative id: GO:0008557
has broad synonym: flippase activity
has db xref: EC:3.6.3.1
has db xref: MetaCyc:3.6.3.1-RXN
has db xref: RHEA:14992
has db xref: Reactome:REACT_115892
has db xref: Reactome:REACT_24989
has exact synonym: ATP phosphohydrolase (phospholipid-flipping)
has exact synonym: Mg2+-ATPase activity
has exact synonym: phospholipid translocating ATPase activity
has exact synonym: phospholipid-transporting ATPase activity
has narrow synonym: aminophospholipid-transporting ATPase
has OBO namespace: molecular_function
has related synonym: Mg(2+)-ATPase activity
has related synonym: magnesium-ATPase activity
id: GO:0004012
in subset: gosubset prok
type: Class
subclass of: GO_0005548
subclass of: GO_0043492

adenosylhomocysteinase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
has broad synonym: S-adenosylhomocysteine hydrolase activity
has db xref: EC:3.3.1.1
has db xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN
has db xref: RHEA:21711
has db xref: Reactome:REACT_100355
has db xref: Reactome:REACT_100496
has db xref: Reactome:REACT_102024
has db xref: Reactome:REACT_107160
has db xref: Reactome:REACT_109196
has db xref: Reactome:REACT_109745
has db xref: Reactome:REACT_110610
has db xref: Reactome:REACT_28097
has db xref: Reactome:REACT_30892
has db xref: Reactome:REACT_31016
has db xref: Reactome:REACT_6756
has db xref: Reactome:REACT_77798
has db xref: Reactome:REACT_77951
has db xref: Reactome:REACT_80809
has db xref: Reactome:REACT_88005
has db xref: Reactome:REACT_95489
has db xref: Reactome:REACT_99437
has exact synonym: AdoHcyase activity
has exact synonym: S-adenosyl-L-homocysteine hydrolase activity
has exact synonym: S-adenosylhomocysteinase activity
has exact synonym: S-adenosylhomocysteine synthase activity
has exact synonym: SAHase activity
has exact synonym: adenosylhomocysteine hydrolase activity
has OBO namespace: molecular_function
id: GO:0004013
in subset: gosubset prok
type: Class
subclass of: GO_0016802

adenosylmethionine decarboxylase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2).
has db xref: EC:4.1.1.50
has db xref: KEGG:R00178
has db xref: MetaCyc:SAMDECARB-RXN
has db xref: RHEA:15984
has db xref: Reactome:REACT_102265
has db xref: Reactome:REACT_106380
has db xref: Reactome:REACT_106530
has db xref: Reactome:REACT_108018
has db xref: Reactome:REACT_109548
has db xref: Reactome:REACT_110722
has db xref: Reactome:REACT_14840
has db xref: Reactome:REACT_28215
has db xref: Reactome:REACT_78516
has db xref: Reactome:REACT_79319
has db xref: Reactome:REACT_80263
has db xref: Reactome:REACT_81987
has db xref: Reactome:REACT_89351
has db xref: Reactome:REACT_90930
has db xref: Reactome:REACT_96438
has exact synonym: S-adenosyl-L-methionine carboxy-lyase activity
has exact synonym: S-adenosyl-L-methionine decarboxylase activity
has exact synonym: S-adenosylmethionine decarboxylase activity
has exact synonym: adenosyl methionine decarboxylase activity
has OBO namespace: molecular_function
has related synonym: S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]
id: GO:0004014
in subset: gosubset prok
type: Class
subclass of: GO_0016831

adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAO_0000115: Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.
has db xref: EC:2.6.1.62
has db xref: KEGG:R03231
has db xref: MetaCyc:DAPASYN-RXN
has db xref: RHEA:16864
has exact synonym: 7,8-diamino-pelargonic acid aminotransferase activity
has exact synonym: 7,8-diaminonanoate transaminase activity
has exact synonym: 7,8-diaminononanoate aminotransferase activity
has exact synonym: 7,8-diaminononanoate transaminase activity
has exact synonym: 7,8-diaminopelargonic acid aminotransferase activity
has exact synonym: 7-keto-8-aminopelargonic acid aminotransferase activity
has exact synonym: DAPA aminotransferase activity
has exact synonym: DAPA transaminase activity
has exact synonym: S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity
has exact synonym: adenosyl methionine-8-amino-7-oxononanoate transaminase activity
has exact synonym: adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity
has exact synonym: adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity
has exact synonym: diaminopelargonate synthase activity
has OBO namespace: molecular_function
has related synonym: 7-keto-8-aminopelargonic acid
id: GO:0004015
in subset: gosubset prok
type: Class
subclass of: GO_0008483

adenylate cyclase activity
IAO_0000115: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
has db xref: EC:4.6.1.1
has db xref: MetaCyc:ADENYLATECYC-RXN
has db xref: RHEA:15392
has db xref: Reactome:REACT_101083
has db xref: Reactome:REACT_103498
has db xref: Reactome:REACT_104211
has db xref: Reactome:REACT_106348
has db xref: Reactome:REACT_110132
has db xref: Reactome:REACT_110346
has db xref: Reactome:REACT_114273
has db xref: Reactome:REACT_114694
has db xref: Reactome:REACT_1292
has db xref: Reactome:REACT_15399
has db xref: Reactome:REACT_18321
has db xref: Reactome:REACT_19249
has db xref: Reactome:REACT_19407
has db xref: Reactome:REACT_20564
has db xref: Reactome:REACT_28885
has db xref: Reactome:REACT_28984
has db xref: Reactome:REACT_30072
has db xref: Reactome:REACT_30354
has db xref: Reactome:REACT_32296
has db xref: Reactome:REACT_77589
has db xref: Reactome:REACT_77648
has db xref: Reactome:REACT_77920
has db xref: Reactome:REACT_78464
has db xref: Reactome:REACT_78878
has db xref: Reactome:REACT_79135
has db xref: Reactome:REACT_79837
has db xref: Reactome:REACT_80253
has db xref: Reactome:REACT_80404
has db xref: Reactome:REACT_80465
has db xref: Reactome:REACT_80777
has db xref: Reactome:REACT_81089
has db xref: Reactome:REACT_81527
has db xref: Reactome:REACT_81605
has db xref: Reactome:REACT_84068
has db xref: Reactome:REACT_84304
has db xref: Reactome:REACT_84639
has db xref: Reactome:REACT_85469
has db xref: Reactome:REACT_85953
has db xref: Reactome:REACT_86733
has db xref: Reactome:REACT_87138
has db xref: Reactome:REACT_92664
has db xref: Reactome:REACT_92794
has db xref: Reactome:REACT_93757
has db xref: Reactome:REACT_94136
has db xref: Reactome:REACT_97516
has exact synonym: 3',5'-cyclic AMP synthetase activity
has exact synonym: ATP diphosphate-lyase (cyclizing) activity
has exact synonym: ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
has exact synonym: ATP pyrophosphate-lyase activity
has exact synonym: adenyl cyclase activity
has exact synonym: adenylyl cyclase activity
has exact synonym: adenylylcyclase activity
has OBO namespace: molecular_function
has related synonym: cAMP generating peptide activity
id: GO:0004016
in subset: gosubset prok
type: Class
subclass of: GO_0009975
subclass of: GO_0016849

adenylate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + AMP = 2 ADP.
has db xref: EC:2.7.4.3
has db xref: MetaCyc:ADENYL-KIN-RXN
has db xref: RHEA:12976
has db xref: Reactome:REACT_100300
has db xref: Reactome:REACT_100354
has db xref: Reactome:REACT_100509
has db xref: Reactome:REACT_100999
has db xref: Reactome:REACT_101925
has db xref: Reactome:REACT_101986
has db xref: Reactome:REACT_102985
has db xref: Reactome:REACT_103652
has db xref: Reactome:REACT_104314
has db xref: Reactome:REACT_106139
has db xref: Reactome:REACT_107217
has db xref: Reactome:REACT_109890
has db xref: Reactome:REACT_110965
has db xref: Reactome:REACT_114340
has db xref: Reactome:REACT_114949
has db xref: Reactome:REACT_2031
has db xref: Reactome:REACT_29050
has db xref: Reactome:REACT_29136
has db xref: Reactome:REACT_31416
has db xref: Reactome:REACT_31539
has db xref: Reactome:REACT_32379
has db xref: Reactome:REACT_32517
has db xref: Reactome:REACT_33002
has db xref: Reactome:REACT_33987
has db xref: Reactome:REACT_34796
has db xref: Reactome:REACT_390
has db xref: Reactome:REACT_643
has db xref: Reactome:REACT_763
has db xref: Reactome:REACT_78886
has db xref: Reactome:REACT_78917
has db xref: Reactome:REACT_79891
has db xref: Reactome:REACT_80849
has db xref: Reactome:REACT_80989
has db xref: Reactome:REACT_82847
has db xref: Reactome:REACT_84010
has db xref: Reactome:REACT_84704
has db xref: Reactome:REACT_85367
has db xref: Reactome:REACT_85846
has db xref: Reactome:REACT_87077
has db xref: Reactome:REACT_87621
has db xref: Reactome:REACT_88917
has db xref: Reactome:REACT_88924
has db xref: Reactome:REACT_90905
has db xref: Reactome:REACT_91426
has db xref: Reactome:REACT_91927
has db xref: Reactome:REACT_92343
has db xref: Reactome:REACT_92843
has db xref: Reactome:REACT_92937
has db xref: Reactome:REACT_93851
has db xref: Reactome:REACT_94373
has db xref: Reactome:REACT_95537
has db xref: Reactome:REACT_96203
has db xref: Reactome:REACT_96441
has db xref: Reactome:REACT_97658
has db xref: Reactome:REACT_98806
has db xref: Reactome:REACT_99365
has exact synonym: 5'-AMP-kinase activity
has exact synonym: ATP:AMP phosphotransferase activity
has exact synonym: adenylic kinase activity
has exact synonym: adenylokinase activity
has narrow synonym: myokinase activity
has OBO namespace: molecular_function
id: GO:0004017
in subset: gosubset prok
type: Class
subclass of: GO_0016776
subclass of: GO_0019201

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
IAO_0000115: Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
has broad synonym: adenylosuccinase activity
has broad synonym: adenylosuccinate lyase activity
has broad synonym: succino AMP-lyase activity
has db xref: EC:4.3.2.2
has db xref: KEGG:R01083
has db xref: MetaCyc:AMPSYN-RXN
has db xref: RHEA:16856
has db xref: Reactome:REACT_101613
has db xref: Reactome:REACT_101814
has db xref: Reactome:REACT_102293
has db xref: Reactome:REACT_103002
has db xref: Reactome:REACT_1042
has db xref: Reactome:REACT_104702
has db xref: Reactome:REACT_105061
has db xref: Reactome:REACT_106004
has db xref: Reactome:REACT_115559
has db xref: Reactome:REACT_1463
has db xref: Reactome:REACT_28507
has db xref: Reactome:REACT_29780
has db xref: Reactome:REACT_29974
has db xref: Reactome:REACT_32835
has db xref: Reactome:REACT_41804
has db xref: Reactome:REACT_80345
has db xref: Reactome:REACT_80474
has db xref: Reactome:REACT_80585
has db xref: Reactome:REACT_80701
has db xref: Reactome:REACT_81241
has db xref: Reactome:REACT_81311
has db xref: Reactome:REACT_83223
has db xref: Reactome:REACT_84337
has db xref: Reactome:REACT_85458
has db xref: Reactome:REACT_87024
has db xref: Reactome:REACT_88636
has db xref: Reactome:REACT_89158
has db xref: Reactome:REACT_90078
has db xref: Reactome:REACT_95334
has db xref: Reactome:REACT_95492
has db xref: Reactome:REACT_99110
has db xref: Reactome:REACT_99135
has db xref: Reactome:REACT_99570
has exact synonym: 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity
has exact synonym: N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity
has OBO namespace: molecular_function
id: GO:0004018
in subset: gosubset prok
type: Class
subclass of: GO_0016842

adenylosuccinate synthase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
has db xref: EC:6.3.4.4
has db xref: KEGG:R01135
has db xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN
has db xref: RHEA:15756
has db xref: Reactome:REACT_101481
has db xref: Reactome:REACT_102582
has db xref: Reactome:REACT_106893
has db xref: Reactome:REACT_108314
has db xref: Reactome:REACT_108485
has db xref: Reactome:REACT_110282
has db xref: Reactome:REACT_110567
has db xref: Reactome:REACT_110657
has db xref: Reactome:REACT_115645
has db xref: Reactome:REACT_1719
has db xref: Reactome:REACT_2217
has db xref: Reactome:REACT_34115
has db xref: Reactome:REACT_77813
has db xref: Reactome:REACT_80422
has db xref: Reactome:REACT_81626
has db xref: Reactome:REACT_81912
has db xref: Reactome:REACT_84271
has db xref: Reactome:REACT_86165
has db xref: Reactome:REACT_92014
has db xref: Reactome:REACT_93976
has db xref: Reactome:REACT_97311
has db xref: Reactome:REACT_98715
has db xref: Reactome:REACT_99701
has exact synonym: IMP--aspartate ligase activity
has exact synonym: IMP:L-aspartate ligase (GDP-forming)
has exact synonym: adenylosuccinate synthetase activity
has exact synonym: succino-AMP synthetase activity
has exact synonym: succinoadenylic kinosynthetase activity
has OBO namespace: molecular_function
id: GO:0004019
in subset: gosubset prok
type: Class
subclass of: GO_0016879

adenylylsulfate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.
has db xref: EC:2.7.1.25
has db xref: MetaCyc:ADENYLYLSULFKIN-RXN
has db xref: RHEA:24155
has db xref: Reactome:REACT_102982
has db xref: Reactome:REACT_106160
has db xref: Reactome:REACT_107506
has db xref: Reactome:REACT_108569
has db xref: Reactome:REACT_109087
has db xref: Reactome:REACT_109654
has db xref: Reactome:REACT_112719
has db xref: Reactome:REACT_27248
has db xref: Reactome:REACT_29708
has db xref: Reactome:REACT_30753
has db xref: Reactome:REACT_34307
has db xref: Reactome:REACT_6792
has db xref: Reactome:REACT_77453
has db xref: Reactome:REACT_80762
has db xref: Reactome:REACT_96385
has db xref: Reactome:REACT_98813
has exact synonym: 5'-phosphoadenosine sulfate kinase activity
has exact synonym: APS kinase activity
has exact synonym: ATP:adenylyl-sulfate 3'-phosphotransferase activity
has exact synonym: adenosine 5'-phosphosulfate kinase activity
has exact synonym: adenosine phosphosulfate kinase activity
has exact synonym: adenosine phosphosulfokinase activity
has exact synonym: adenosine-5'-phosphosulfate 3'-phosphotransferase activity
has exact synonym: adenosine-5'-phosphosulfate-3'-phosphokinase activity
has exact synonym: adenosine-5'-phosphosulphate 3'-phosphotransferase activity
has exact synonym: adenylyl-sulfate kinase activity
has exact synonym: adenylyl-sulphate kinase activity
has exact synonym: adenylylsulfate kinase (phosphorylating)
has OBO namespace: molecular_function
id: GO:0004020
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

L-alanine:2-oxoglutarate aminotransferase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
has broad synonym: L-alanine aminotransferase activity
has broad synonym: L-alanine transaminase activity
has broad synonym: alanine aminotransferase activity
has broad synonym: alanine transaminase activity
has broad synonym: beta-alanine aminotransferase
has broad synonym: pyruvate transaminase activity
has db xref: EC:2.6.1.2
has db xref: KEGG:R00258
has db xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN
has db xref: RHEA:19456
has db xref: Reactome:REACT_101406
has db xref: Reactome:REACT_101725
has db xref: Reactome:REACT_102570
has db xref: Reactome:REACT_104815
has db xref: Reactome:REACT_104823
has db xref: Reactome:REACT_106468
has db xref: Reactome:REACT_110990
has db xref: Reactome:REACT_196
has db xref: Reactome:REACT_21263
has db xref: Reactome:REACT_21311
has db xref: Reactome:REACT_29599
has db xref: Reactome:REACT_30303
has db xref: Reactome:REACT_31969
has db xref: Reactome:REACT_32776
has db xref: Reactome:REACT_356
has db xref: Reactome:REACT_60750
has db xref: Reactome:REACT_78782
has db xref: Reactome:REACT_79645
has db xref: Reactome:REACT_80629
has db xref: Reactome:REACT_80730
has db xref: Reactome:REACT_82015
has db xref: Reactome:REACT_83615
has db xref: Reactome:REACT_87728
has db xref: Reactome:REACT_88275
has db xref: Reactome:REACT_88337
has db xref: Reactome:REACT_89745
has db xref: Reactome:REACT_91288
has db xref: Reactome:REACT_91807
has db xref: Reactome:REACT_92910
has db xref: Reactome:REACT_93831
has db xref: Reactome:REACT_94700
has db xref: Reactome:REACT_99170
has exact synonym: L-alanine-alpha-ketoglutarate aminotransferase activity
has exact synonym: alanine-alpha-ketoglutarate aminotransferase activity
has exact synonym: alanine-pyruvate aminotransferase activity
has exact synonym: glutamic acid-pyruvic acid transaminase activity
has exact synonym: glutamic--alanine transaminase activity
has exact synonym: glutamic--pyruvic transaminase activity
has exact synonym: glutamic-pyruvic aminotransferase activity
has exact synonym: pyruvate-alanine aminotransferase activity
has exact synonym: pyruvate-glutamate transaminase activity
has OBO namespace: molecular_function
has related synonym: ALT
has related synonym: GPT
id: GO:0004021
in subset: gosubset prok
type: Class
subclass of: GO_0047635

alcohol dehydrogenase (NAD) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
has broad synonym: alcohol dehydrogenase activity
has broad synonym: primary alcohol dehydrogenase
has db xref: EC:1.1.1.1
has db xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN
has db xref: UM-BBD_enzymeID:e0023
has exact synonym: NAD-dependent alcohol dehydrogenase
has exact synonym: NAD-specific aromatic alcohol dehydrogenase
has exact synonym: NADH-alcohol dehydrogenase
has exact synonym: NADH-aldehyde dehydrogenase
has exact synonym: alcohol:NAD+ oxidoreductase
has exact synonym: aldo-keto reductase (NAD) activity
has narrow synonym: aldehyde dehydrogenase (NAD) activity
has narrow synonym: aliphatic alcohol dehydrogenase
has narrow synonym: ethanol dehydrogenase
has narrow synonym: yeast alcohol dehydrogenase
has OBO namespace: molecular_function
has related synonym: ADH
id: GO:0004022
in subset: gosubset prok
type: Class
subclass of: GO_0016616

alcohol dehydrogenase activity, metal ion-independent
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion.
has OBO namespace: molecular_function
id: GO:0004023
type: Class
subclass of: alcohol dehydrogenase (NAD) activity

alcohol dehydrogenase activity, zinc-dependent
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.
has db xref: Reactome:REACT_107562
has db xref: Reactome:REACT_1431
has db xref: Reactome:REACT_28919
has db xref: Reactome:REACT_31030
has db xref: Reactome:REACT_33588
has db xref: Reactome:REACT_52273
has db xref: Reactome:REACT_90358
has db xref: Reactome:REACT_90708
has db xref: Reactome:REACT_92592
has OBO namespace: molecular_function
id: GO:0004024
in subset: gosubset prok
type: Class
subclass of: alcohol dehydrogenase (NAD) activity

alcohol dehydrogenase activity, iron-dependent
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron.
has OBO namespace: molecular_function
id: GO:0004025
in subset: gosubset prok
type: Class
subclass of: alcohol dehydrogenase (NAD) activity

alcohol O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.
has db xref: EC:2.3.1.84
has db xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN
has exact synonym: AATASE activity
has exact synonym: acetyl-CoA:alcohol O-acetyltransferase activity
has exact synonym: alcohol acetyltransferase activity
has OBO namespace: molecular_function
id: GO:0004026
type: Class
subclass of: GO_0016413
subclass of: GO_0034318

alcohol sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
has broad synonym: estrogen sulfotransferase
has broad synonym: steroid alcohol sulfotransferase
has db xref: EC:2.8.2.2
has db xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN
has db xref: Reactome:REACT_101584
has db xref: Reactome:REACT_34593
has db xref: Reactome:REACT_59193
has db xref: Reactome:REACT_6881
has db xref: Reactome:REACT_6957
has db xref: Reactome:REACT_79006
has db xref: Reactome:REACT_80452
has db xref: Reactome:REACT_94728
has db xref: Reactome:REACT_95422
has db xref: Reactome:REACT_96417
has exact synonym: 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity
has exact synonym: 3-hydroxysteroid sulfotransferase activity
has exact synonym: 3beta-hydroxy steroid sulfotransferase activity
has exact synonym: 3beta-hydroxysteroid sulfotransferase activity
has exact synonym: 5alpha-androstenol sulfotransferase activity
has exact synonym: alcohol sulphotransferase activity
has exact synonym: alcohol/hydroxysteroid sulfotransferase activity
has exact synonym: dehydroepiandrosterone sulfotransferase activity
has exact synonym: delta5-3beta-hydroxysteroid sulfokinase activity
has exact synonym: estrogen sulfokinase activity
has exact synonym: hydroxysteroid sulfotransferase activity
has exact synonym: steroid sulfokinase activity
has exact synonym: sterol sulfokinase activity
has exact synonym: sterol sulfotransferase activity
has OBO namespace: molecular_function
has related synonym: HST
id: GO:0004027
in subset: gosubset prok
type: Class
subclass of: GO_0008146

3-chloroallyl aldehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
has db xref: EC:1.2.1.-
has db xref: Reactome:REACT_100428
has db xref: Reactome:REACT_102182
has db xref: Reactome:REACT_102594
has db xref: Reactome:REACT_104268
has db xref: Reactome:REACT_220
has db xref: Reactome:REACT_32159
has db xref: Reactome:REACT_54249
has db xref: Reactome:REACT_78707
has db xref: Reactome:REACT_80702
has db xref: Reactome:REACT_86482
has db xref: Reactome:REACT_99167
has db xref: Reactome:REACT_99233
has db xref: UM-BBD_enzymeID:e0432
has OBO namespace: molecular_function
id: GO:0004028
in subset: gosubset prok
type: Class
subclass of: GO_0016620

aldehyde dehydrogenase (NAD) activity
IAO_0000115: Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
has db xref: EC:1.2.1.3
has db xref: MetaCyc:ALDHDEHYDROG-RXN
has db xref: RHEA:16188
has db xref: Reactome:REACT_100473
has db xref: Reactome:REACT_103621
has db xref: Reactome:REACT_104849
has db xref: Reactome:REACT_105050
has db xref: Reactome:REACT_105669
has db xref: Reactome:REACT_105847
has db xref: Reactome:REACT_105932
has db xref: Reactome:REACT_1080
has db xref: Reactome:REACT_110301
has db xref: Reactome:REACT_110943
has db xref: Reactome:REACT_112729
has db xref: Reactome:REACT_112808
has db xref: Reactome:REACT_113173
has db xref: Reactome:REACT_113214
has db xref: Reactome:REACT_113740
has db xref: Reactome:REACT_114032
has db xref: Reactome:REACT_114609
has db xref: Reactome:REACT_115403
has db xref: Reactome:REACT_15407
has db xref: Reactome:REACT_16919
has db xref: Reactome:REACT_2127
has db xref: Reactome:REACT_30242
has db xref: Reactome:REACT_30317
has db xref: Reactome:REACT_30455
has db xref: Reactome:REACT_31589
has db xref: Reactome:REACT_34252
has db xref: Reactome:REACT_78762
has db xref: Reactome:REACT_80267
has db xref: Reactome:REACT_81293
has db xref: Reactome:REACT_83193
has db xref: Reactome:REACT_83627
has db xref: Reactome:REACT_83939
has db xref: Reactome:REACT_84001
has db xref: Reactome:REACT_85596
has db xref: Reactome:REACT_86116
has db xref: Reactome:REACT_86294
has db xref: Reactome:REACT_86661
has db xref: Reactome:REACT_87336
has db xref: Reactome:REACT_88233
has db xref: Reactome:REACT_89302
has db xref: Reactome:REACT_89718
has db xref: Reactome:REACT_91587
has db xref: Reactome:REACT_91840
has db xref: Reactome:REACT_93677
has db xref: Reactome:REACT_97751
has db xref: Reactome:REACT_99086
has db xref: UM-BBD_enzymeID:e0024
has db xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+)
has exact synonym: CoA-independent aldehyde dehydrogenase activity
has exact synonym: NAD-aldehyde dehydrogenase activity
has exact synonym: NAD-dependent 4-hydroxynonenal dehydrogenase activity
has exact synonym: NAD-dependent aldehyde dehydrogenase activity
has exact synonym: NAD-linked aldehyde dehydrogenase activity
has exact synonym: aldehyde dehydrogenase (NAD+)
has exact synonym: aldehyde:NAD+ oxidoreductase activity
has exact synonym: m-methylbenzaldehyde dehydrogenase activity
has exact synonym: propionaldehyde dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004029
in subset: gosubset prok
type: Class
subclass of: GO_0016620

aldehyde dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
has db xref: EC:1.2.1.5
has db xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN
has exact synonym: aldehyde:NAD(P)+ oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: ALDH
id: GO:0004030
in subset: gosubset prok
type: Class
subclass of: GO_0016620

aldehyde oxidase activity
IAO_0000115: Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
has db xref: EC:1.2.3.1
has db xref: MetaCyc:ALDEHYDE-OXIDASE-RXN
has db xref: RHEA:16832
has exact synonym: aldehyde:oxygen oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: quinoline oxidase activity
id: GO:0004031
in subset: gosubset prok
type: Class
subclass of: GO_0016623

alditol:NADP+ 1-oxidoreductase activity
IAO_0000115: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
has db xref: EC:1.1.1.21
has db xref: KEGG:R02820
has db xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN
has db xref: Reactome:REACT_105330
has db xref: Reactome:REACT_107111
has db xref: Reactome:REACT_110163
has db xref: Reactome:REACT_112305
has db xref: Reactome:REACT_112358
has db xref: Reactome:REACT_114284
has db xref: Reactome:REACT_31934
has db xref: Reactome:REACT_32005
has db xref: Reactome:REACT_32567
has db xref: Reactome:REACT_32715
has db xref: Reactome:REACT_91048
has db xref: Reactome:REACT_92726
has db xref: Reactome:REACT_94458
has db xref: Reactome:REACT_9986
has exact synonym: aldose reductase activity
has OBO namespace: molecular_function
has related synonym: polyol dehydrogenase (NADP(+)) activity
id: GO:0004032
in subset: gosubset prok
type: Class
subclass of: GO_0008106

aldo-keto reductase (NADP) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
has db xref: EC:1.1.1.-
has db xref: Reactome:REACT_10008
has db xref: Reactome:REACT_10018
has db xref: Reactome:REACT_10038
has db xref: Reactome:REACT_10044
has db xref: Reactome:REACT_100460
has db xref: Reactome:REACT_10048
has db xref: Reactome:REACT_10054
has db xref: Reactome:REACT_10068
has db xref: Reactome:REACT_10086
has db xref: Reactome:REACT_10102
has db xref: Reactome:REACT_10120
has db xref: Reactome:REACT_10131
has db xref: Reactome:REACT_101534
has db xref: Reactome:REACT_101629
has db xref: Reactome:REACT_101931
has db xref: Reactome:REACT_104573
has db xref: Reactome:REACT_104664
has db xref: Reactome:REACT_104786
has db xref: Reactome:REACT_105193
has db xref: Reactome:REACT_106036
has db xref: Reactome:REACT_106194
has db xref: Reactome:REACT_106928
has db xref: Reactome:REACT_108439
has db xref: Reactome:REACT_108757
has db xref: Reactome:REACT_110383
has db xref: Reactome:REACT_110687
has db xref: Reactome:REACT_110920
has db xref: Reactome:REACT_11100
has db xref: Reactome:REACT_111993
has db xref: Reactome:REACT_112004
has db xref: Reactome:REACT_112078
has db xref: Reactome:REACT_112094
has db xref: Reactome:REACT_112136
has db xref: Reactome:REACT_112164
has db xref: Reactome:REACT_112352
has db xref: Reactome:REACT_112380
has db xref: Reactome:REACT_112446
has db xref: Reactome:REACT_112477
has db xref: Reactome:REACT_112538
has db xref: Reactome:REACT_112546
has db xref: Reactome:REACT_112547
has db xref: Reactome:REACT_112635
has db xref: Reactome:REACT_112765
has db xref: Reactome:REACT_112786
has db xref: Reactome:REACT_112971
has db xref: Reactome:REACT_113067
has db xref: Reactome:REACT_113108
has db xref: Reactome:REACT_113453
has db xref: Reactome:REACT_113482
has db xref: Reactome:REACT_113545
has db xref: Reactome:REACT_113590
has db xref: Reactome:REACT_113657
has db xref: Reactome:REACT_113694
has db xref: Reactome:REACT_113742
has db xref: Reactome:REACT_113762
has db xref: Reactome:REACT_113791
has db xref: Reactome:REACT_113879
has db xref: Reactome:REACT_113982
has db xref: Reactome:REACT_114182
has db xref: Reactome:REACT_114303
has db xref: Reactome:REACT_114413
has db xref: Reactome:REACT_114451
has db xref: Reactome:REACT_114529
has db xref: Reactome:REACT_114561
has db xref: Reactome:REACT_114574
has db xref: Reactome:REACT_114601
has db xref: Reactome:REACT_114670
has db xref: Reactome:REACT_114682
has db xref: Reactome:REACT_114688
has db xref: Reactome:REACT_114788
has db xref: Reactome:REACT_114934
has db xref: Reactome:REACT_114943
has db xref: Reactome:REACT_114951
has db xref: Reactome:REACT_115178
has db xref: Reactome:REACT_115352
has db xref: Reactome:REACT_115369
has db xref: Reactome:REACT_115407
has db xref: Reactome:REACT_28191

aldose 1-epimerase activity
IAO_0000115: Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose.
has db xref: EC:5.1.3.3
has db xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN
has db xref: RHEA:10267
has OBO namespace: molecular_function
has related synonym: aldose mutarotase activity
has related synonym: mutarotase activity
id: GO:0004034
in subset: gosubset prok
type: Class
subclass of: GO_0016857

alkaline phosphatase activity
IAO_0000115: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
has broad synonym: glycerophosphatase activity
has broad synonym: phosphomonoesterase activity
has db xref: EC:3.1.3.1
has db xref: MetaCyc:ALKAPHOSPHA-RXN
has exact synonym: alkaline phenyl phosphatase activity
has exact synonym: alkaline phosphohydrolase activity
has exact synonym: alkaline phosphomonoesterase activity
has exact synonym: orthophosphoric-monoester phosphohydrolase (alkaline optimum)
has exact synonym: phosphate-monoester phosphohydrolase (alkaline optimum)
has OBO namespace: molecular_function
id: GO:0004035
in subset: gosubset prok
type: Class
subclass of: GO_0016791

allantoicase activity
IAO_0000115: Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea.
has db xref: EC:3.5.3.4
has db xref: KEGG:R02422
has db xref: MetaCyc:ALLANTOICASE-RXN
has db xref: RHEA:11019
has exact synonym: allantoate amidinohydrolase activity
has exact synonym: allantoine amidinohydrolase activity
has OBO namespace: molecular_function
id: GO:0004037
in subset: gosubset prok
type: Class
subclass of: GO_0016813

allantoinase activity
IAO_0000115: Catalysis of the reaction: allantoin + H2O = allantoate.
has db xref: EC:3.5.2.5
has db xref: MetaCyc:ALLANTOINASE-RXN
has db xref: RHEA:17032
has exact synonym: (S)-allantoin amidohydrolase activity
has OBO namespace: molecular_function
id: GO:0004038
in subset: gosubset prok
type: Class
subclass of: GO_0016812

allophanate hydrolase activity
IAO_0000115: Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+).
has db xref: EC:3.5.1.54
has db xref: KEGG:R00005
has db xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN
has db xref: RHEA:19032
has db xref: UM-BBD_reactionID:r0848
has exact synonym: allophanate lyase activity
has exact synonym: urea-1-carboxylate amidohydrolase activity
has OBO namespace: molecular_function
id: GO:0004039
in subset: gosubset prok
type: Class
subclass of: GO_0016811

amidase activity
IAO_0000115: Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.
has db xref: EC:3.5.1.4
has db xref: MetaCyc:AMIDASE-RXN
has db xref: UM-BBD_enzymeID:e0068
has exact synonym: N-acetylaminohydrolase activity
has exact synonym: acetamidase activity
has exact synonym: acylamidase activity
has exact synonym: acylamide amidohydrolase activity
has exact synonym: acylase activity
has exact synonym: amidohydrolase activity
has exact synonym: fatty acylamidase activity
has OBO namespace: molecular_function
id: GO:0004040
in subset: gosubset prok
type: Class
subclass of: GO_0016811

acetyl-CoA:L-glutamate N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+).
has broad synonym: N-acetylglutamate synthase activity
has broad synonym: amino-acid N-acetyltransferase activity
has db xref: EC:2.3.1.1
has db xref: KEGG:R00259
has db xref: MetaCyc:N-ACETYLTRANSFER-RXN
has db xref: RHEA:24295
has db xref: Reactome:REACT_102238
has db xref: Reactome:REACT_108325
has db xref: Reactome:REACT_2139
has db xref: Reactome:REACT_29654
has db xref: Reactome:REACT_31801
has db xref: Reactome:REACT_81010
has db xref: Reactome:REACT_81256
has db xref: Reactome:REACT_85183
has db xref: Reactome:REACT_89124
has db xref: Reactome:REACT_94579
has db xref: Reactome:REACT_99960
has exact synonym: acetylglutamate acetylglutamate synthetase activity
has exact synonym: amino acid acetyltransferase activity
has OBO namespace: molecular_function
has related synonym: AGAS
id: GO:0004042
in subset: gosubset prok
type: Class
subclass of: GO_0008080

L-aminoadipate-semialdehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
has db xref: EC:1.2.1.31
has db xref: MetaCyc:1.2.1.31-RXN
has db xref: Reactome:REACT_110440
has db xref: Reactome:REACT_1540
has db xref: Reactome:REACT_34232
has db xref: Reactome:REACT_34396
has db xref: Reactome:REACT_77435
has db xref: Reactome:REACT_79544
has db xref: Reactome:REACT_80215
has db xref: Reactome:REACT_80324
has db xref: Reactome:REACT_81404
has db xref: Reactome:REACT_84541
has db xref: Reactome:REACT_86291
has db xref: Reactome:REACT_88752
has db xref: Reactome:REACT_92070
has db xref: Reactome:REACT_92791
has db xref: Reactome:REACT_95793
has db xref: Reactome:REACT_97958
has exact synonym: 2-aminoadipate semialdehyde dehydrogenase activity
has exact synonym: 2-aminoadipic semialdehyde dehydrogenase activity
has exact synonym: AAR
has exact synonym: L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
has exact synonym: L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
has exact synonym: L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
has exact synonym: L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
has exact synonym: alpha-aminoadipate reductase activity
has exact synonym: alpha-aminoadipate-semialdehyde dehydrogenase activity
has exact synonym: aminoadipate semialdehyde dehydrogenase activity
has exact synonym: aminoadipate-semialdehyde dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004043
in subset: gosubset prok
type: Class
subclass of: GO_0016620

amidophosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.
has db xref: EC:2.4.2.14
has db xref: KEGG:R01072
has db xref: MetaCyc:PRPPAMIDOTRANS-RXN
has db xref: RHEA:14908
has db xref: Reactome:REACT_102786
has db xref: Reactome:REACT_103149
has db xref: Reactome:REACT_106474
has db xref: Reactome:REACT_116094
has db xref: Reactome:REACT_30841
has db xref: Reactome:REACT_32820
has db xref: Reactome:REACT_33476
has db xref: Reactome:REACT_740
has db xref: Reactome:REACT_76986
has db xref: Reactome:REACT_78155
has db xref: Reactome:REACT_80319
has db xref: Reactome:REACT_84289
has db xref: Reactome:REACT_85912
has db xref: Reactome:REACT_86712
has db xref: Reactome:REACT_87917
has db xref: Reactome:REACT_90579
has db xref: Reactome:REACT_93984
has db xref: Reactome:REACT_94540
has db xref: Reactome:REACT_95631
has db xref: Reactome:REACT_98124
has db xref: Reactome:REACT_99042
has exact synonym: 5'-phosphoribosylpyrophosphate amidotransferase activity
has exact synonym: 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
has exact synonym: 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
has exact synonym: 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
has exact synonym: alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
has exact synonym: glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
has exact synonym: glutamine phosphoribosyldiphosphate amidotransferase activity
has exact synonym: glutamine phosphoribosylpyrophosphate amidotransferase activity
has exact synonym: glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
has exact synonym: phosphoribose pyrophosphate amidotransferase activity
has exact synonym: phosphoribosyl pyrophosphate amidotransferase activity
has exact synonym: phosphoribosyldiphosphate 5-amidotransferase activity
has exact synonym: phosphoribosylpyrophosphate glutamyl amidotransferase activity
has OBO namespace: molecular_function
id: GO:0004044
in subset: gosubset prok
type: Class
subclass of: GO_0016763

aminoacyl-tRNA hydrolase activity
IAO_0000115: Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
has alternative id: GO:0019850
has alternative id: GO:0019851
has db xref: EC:3.1.1.29
has db xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN
has exact synonym: N-substituted aminoacyl transfer RNA hydrolase activity
has exact synonym: aminoacyl-tRNA aminoacylhydrolase activity
has exact synonym: aminoacyl-tRNA hydrolase reaction
has exact synonym: aminoacyl-transfer ribonucleate hydrolase activity
has exact synonym: peptidyl-tRNA hydrolase activity
has narrow synonym: D-tyrosyl-tRNA hydrolase activity
has OBO namespace: molecular_function
id: GO:0004045
in subset: gosubset prok
type: Class
subclass of: GO_0052689

aminoacylase activity
IAO_0000115: Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.
has db xref: EC:3.5.1.14
has db xref: MetaCyc:AMINOACYLASE-RXN
has db xref: RHEA:15568
has exact synonym: L-amino-acid acylase activity
has exact synonym: L-aminoacylase activity
has exact synonym: N-acyl-L-amino-acid amidohydrolase activity
has exact synonym: alpha-N-acylaminoacid hydrolase activity
has exact synonym: amido acid deacylase activity
has exact synonym: hippurase activity
has exact synonym: long acyl amidoacylase activity
has exact synonym: short acyl amidoacylase activity
has narrow synonym: acylase I activity
has narrow synonym: aminoacylase I activity
has narrow synonym: dehydropeptidase II activity
has OBO namespace: molecular_function
has related synonym: benzamidase activity
has related synonym: histozyme activity
id: GO:0004046
in subset: gosubset prok
type: Class
subclass of: GO_0016811

aminomethyltransferase activity
IAO_0000115: Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
has db xref: EC:2.1.2.10
has db xref: MetaCyc:GCVT-RXN
has db xref: RHEA:16948
has exact synonym: S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has exact synonym: protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has exact synonym: protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has exact synonym: tetrahydrofolate aminomethyltransferase activity
has OBO namespace: molecular_function
has related synonym: T-protein
has related synonym: glycine synthase activity
has related synonym: glycine-cleavage system T-protein activity
id: GO:0004047
in subset: gosubset prok
type: Class
subclass of: GO_0008168

anthranilate phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.
has db xref: EC:2.4.2.18
has db xref: KEGG:R01073
has db xref: MetaCyc:PRTRANS-RXN
has db xref: RHEA:11771
has exact synonym: N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity
has exact synonym: anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity
has exact synonym: anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity
has exact synonym: anthranilate-PP-ribose-P phosphoribosyltransferase activity
has exact synonym: phosphoribosyl-anthranilate diphosphorylase activity
has exact synonym: phosphoribosyl-anthranilate pyrophosphorylase activity
has exact synonym: phosphoribosylanthranilate pyrophosphorylase activity
has exact synonym: phosphoribosylanthranilate transferase activity
has OBO namespace: molecular_function
has related synonym: PRT
id: GO:0004048
in subset: gosubset prok
type: Class
subclass of: GO_0016763

anthranilate synthase activity
IAO_0000115: Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
has db xref: EC:4.1.3.27
has db xref: MetaCyc:ANTHRANSYN-RXN
has db xref: RHEA:21735
has exact synonym: anthranilate synthetase activity
has exact synonym: chorismate pyruvate-lyase (amino-accepting) activity
has OBO namespace: molecular_function
id: GO:0004049
in subset: gosubset prok
type: Class
subclass of: GO_0016833

apyrase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate.
consider: GO:0017110
consider: GO:0017111
has OBO namespace: molecular_function
id: GO:0004050
type: Class
comment: This term was made obsolete because it represents a gene product which can catalyze two reactions.
deprecated: true

arachidonate 5-lipoxygenase activity
IAO_0000115: Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.
has broad synonym: leukotriene A4 synthase
has db xref: EC:1.13.11.34
has db xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN
has db xref: RHEA:24751
has db xref: Reactome:REACT_101081
has db xref: Reactome:REACT_102776
has db xref: Reactome:REACT_104725
has db xref: Reactome:REACT_107795
has db xref: Reactome:REACT_107991
has db xref: Reactome:REACT_109247
has db xref: Reactome:REACT_110901
has db xref: Reactome:REACT_113814
has db xref: Reactome:REACT_115370
has db xref: Reactome:REACT_15337
has db xref: Reactome:REACT_15453
has db xref: Reactome:REACT_28749
has db xref: Reactome:REACT_76963
has db xref: Reactome:REACT_77245
has db xref: Reactome:REACT_78626
has db xref: Reactome:REACT_79548
has db xref: Reactome:REACT_80928
has db xref: Reactome:REACT_84095
has db xref: Reactome:REACT_84894
has db xref: Reactome:REACT_87806
has db xref: Reactome:REACT_90210
has db xref: Reactome:REACT_99738
has exact synonym: 5-delta-lipoxygenase activity
has exact synonym: 5-lipoxygenase activity
has exact synonym: 5Delta-lipoxygenase activity
has exact synonym: arachidonate:oxygen 5-oxidoreductase activity
has exact synonym: arachidonic 5-lipoxygenase activity
has exact synonym: arachidonic acid 5-lipoxygenase activity
has exact synonym: delta5-lipoxygenase activity
has exact synonym: leukotriene-A4 synthase activity
has narrow synonym: LTA synthase activity
has narrow synonym: leukotriene-A(4) synthase activity
has OBO namespace: molecular_function
has related synonym: C-5-lipoxygenase activity
has related synonym: delta(5)-lipoxygenase activity
id: GO:0004051
in subset: gosubset prok
type: Class
subclass of: GO_0016702

arachidonate 12-lipoxygenase activity
IAO_0000115: Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
has broad synonym: leukotriene A4 synthase
has db xref: EC:1.13.11.31
has db xref: KEGG:R01596
has db xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN
has db xref: RHEA:10431
has exact synonym: 12Delta-lipoxygenase activity
has exact synonym: 12S-lipoxygenase activity
has exact synonym: C-12 lipoxygenase activity
has exact synonym: LTA4 synthase activity
has exact synonym: arachidonate:oxygen 12-oxidoreductase activity
has exact synonym: delta12-lipoxygenase activity
has OBO namespace: molecular_function
has related synonym: 12-lipoxygenase activity
id: GO:0004052
type: Class
subclass of: GO_0016702

arginase activity
IAO_0000115: Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
has db xref: EC:3.5.3.1
has db xref: MetaCyc:ARGINASE-RXN
has db xref: RHEA:20572
has db xref: Reactome:REACT_104545
has db xref: Reactome:REACT_105138
has db xref: Reactome:REACT_105399
has db xref: Reactome:REACT_112789
has db xref: Reactome:REACT_115584
has db xref: Reactome:REACT_21325
has db xref: Reactome:REACT_29262
has db xref: Reactome:REACT_394
has db xref: Reactome:REACT_80504
has db xref: Reactome:REACT_83897
has db xref: Reactome:REACT_84916
has db xref: Reactome:REACT_94417
has db xref: Reactome:REACT_94917
has db xref: Reactome:REACT_99000
has db xref: Reactome:REACT_99109
has db xref: Reactome:REACT_99872
has exact synonym: L-arginase activity
has exact synonym: L-arginine amidinohydrolase activity
has exact synonym: arginine amidinase activity
has exact synonym: arginine transamidinase activity
has exact synonym: canavanase activity
has OBO namespace: molecular_function
id: GO:0004053
in subset: gosubset prok
type: Class
subclass of: GO_0016813

arginine kinase activity
IAO_0000115: Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+).
has db xref: EC:2.7.3.3
has db xref: KEGG:R00554
has db xref: MetaCyc:ARGININE-KINASE-RXN
has db xref: RHEA:22943
has exact synonym: ATP:L-arginine N-phosphotransferase activity
has exact synonym: adenosine 5'-triphosphate-arginine phosphotransferase activity
has exact synonym: arginine phosphokinase activity
has OBO namespace: molecular_function
has related synonym: adenosine 5'-triphosphate:L-arginine
id: GO:0004054
type: Class
subclass of: GO_0016775
subclass of: GO_0019202

argininosuccinate synthase activity
IAO_0000115: Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
has db xref: EC:6.3.4.5
has db xref: MetaCyc:ARGSUCCINSYN-RXN
has db xref: RHEA:10935
has db xref: Reactome:REACT_102781
has db xref: Reactome:REACT_102882
has db xref: Reactome:REACT_110988
has db xref: Reactome:REACT_113640
has db xref: Reactome:REACT_115870
has db xref: Reactome:REACT_29799
has db xref: Reactome:REACT_31033
has db xref: Reactome:REACT_482
has db xref: Reactome:REACT_77511
has db xref: Reactome:REACT_78098
has db xref: Reactome:REACT_82273
has db xref: Reactome:REACT_85713
has db xref: Reactome:REACT_93966
has db xref: Reactome:REACT_94014
has db xref: Reactome:REACT_94088
has db xref: Reactome:REACT_95275
has db xref: Reactome:REACT_98246
has db xref: Reactome:REACT_98815
has db xref: Reactome:REACT_99835
has exact synonym: L-citrulline:L-aspartate ligase (AMP-forming)
has exact synonym: arginine succinate synthetase activity
has exact synonym: argininosuccinate synthetase activity
has exact synonym: argininosuccinic acid synthetase activity
has exact synonym: arginosuccinate synthetase activity
has exact synonym: citrulline--aspartate ligase activity
has OBO namespace: molecular_function
id: GO:0004055
in subset: gosubset prok
type: Class
subclass of: GO_0016879

argininosuccinate lyase activity
IAO_0000115: Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.
has db xref: EC:4.3.2.1
has db xref: MetaCyc:ARGSUCCINLYA-RXN
has db xref: RHEA:24023
has db xref: Reactome:REACT_105702
has db xref: Reactome:REACT_107201
has db xref: Reactome:REACT_107341
has db xref: Reactome:REACT_107497
has db xref: Reactome:REACT_108281
has db xref: Reactome:REACT_110613
has db xref: Reactome:REACT_113182
has db xref: Reactome:REACT_114192
has db xref: Reactome:REACT_114884
has db xref: Reactome:REACT_115252
has db xref: Reactome:REACT_116009
has db xref: Reactome:REACT_1378
has db xref: Reactome:REACT_79360
has db xref: Reactome:REACT_79752
has db xref: Reactome:REACT_83325
has db xref: Reactome:REACT_92799
has db xref: Reactome:REACT_94002
has db xref: Reactome:REACT_98490
has db xref: Reactome:REACT_98521
has exact synonym: 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
has exact synonym: 2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)
has exact synonym: N-(L-argininosuccinate) arginine-lyase activity
has exact synonym: arginine-succinate lyase activity
has exact synonym: argininosuccinic acid lyase activity
has exact synonym: arginosuccinase activity
has exact synonym: omega-N-(L-arginino)succinate arginine-lyase activity
has OBO namespace: molecular_function
id: GO:0004056
in subset: gosubset prok
type: Class
subclass of: GO_0016842

arginyltransferase activity
IAO_0000115: Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.
has alternative id: GO:0042172
has db xref: EC:2.3.2.8
has db xref: MetaCyc:ARGINYLTRANSFERASE-RXN
has exact synonym: L-arginyl-tRNA:protein arginyltransferase activity
has exact synonym: arginine transferase activity
has exact synonym: arginyl-tRNA protein transferase activity
has exact synonym: arginyl-tRNA--protein transferase activity
has exact synonym: arginyl-tRNA-protein transferase activity
has exact synonym: arginyl-transfer ribonucleate-protein aminoacyltransferase activity
has exact synonym: arginyl-transfer ribonucleate-protein transferase activity
has OBO namespace: molecular_function
id: GO:0004057
in subset: gosubset prok
type: Class
subclass of: GO_0016755

aromatic-L-amino-acid decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-tryptophan = tryptamine + CO2.
has alternative id: GO:0016400
has db xref: EC:4.1.1.28
has db xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN
has db xref: Reactome:REACT_102788
has db xref: Reactome:REACT_104092
has db xref: Reactome:REACT_107239
has db xref: Reactome:REACT_109359
has db xref: Reactome:REACT_110116
has db xref: Reactome:REACT_110361
has db xref: Reactome:REACT_15382
has db xref: Reactome:REACT_15546
has db xref: Reactome:REACT_29601
has db xref: Reactome:REACT_32557
has db xref: Reactome:REACT_32559
has db xref: Reactome:REACT_32861
has db xref: Reactome:REACT_40024
has db xref: Reactome:REACT_77761
has db xref: Reactome:REACT_78186
has db xref: Reactome:REACT_82232
has db xref: Reactome:REACT_85510
has db xref: Reactome:REACT_87158
has db xref: Reactome:REACT_92081
has db xref: Reactome:REACT_93251
has db xref: Reactome:REACT_96152
has db xref: Reactome:REACT_96639
has db xref: Reactome:REACT_97213
has db xref: Reactome:REACT_97677
has db xref: Reactome:REACT_99387
has db xref: Reactome:REACT_99826
has exact synonym: 5-hydroxytryptophan decarboxylase activity
has exact synonym: DOPA decarboxylase activity
has exact synonym: L-DOPA decarboxylase activity
has exact synonym: aromatic amino acid decarboxylase activity
has exact synonym: aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
has exact synonym: aromatic-L-amino-acid carboxy-lyase activity
has exact synonym: hydroxytryptophan decarboxylase activity
has exact synonym: tryptophan decarboxylase activity
has OBO namespace: molecular_function
id: GO:0004058
type: Class
subclass of: GO_0016831

aralkylamine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.
has db xref: EC:2.3.1.87
has db xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN
has db xref: Reactome:REACT_102250
has db xref: Reactome:REACT_102805
has db xref: Reactome:REACT_104511
has db xref: Reactome:REACT_15290
has db xref: Reactome:REACT_29536
has db xref: Reactome:REACT_33625
has db xref: Reactome:REACT_81480
has db xref: Reactome:REACT_85448
has db xref: Reactome:REACT_86020
has db xref: Reactome:REACT_92297
has exact synonym: AANAT activity
has exact synonym: acetyl-CoA:2-arylethylamine N-acetyltransferase activity
has exact synonym: arylalkylamine N-acetyltransferase activity
has narrow synonym: serotonin N-acetyltransferase activity
has narrow synonym: serotonin acetylase activity
has narrow synonym: serotonin acetyltransferase activity
has OBO namespace: molecular_function
has related synonym: melatonin rhythm enzyme activity
id: GO:0004059
type: Class
subclass of: GO_0008080

arylamine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
has db xref: EC:2.3.1.5
has db xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN
has db xref: Reactome:REACT_104415
has db xref: Reactome:REACT_105583
has db xref: Reactome:REACT_108176
has db xref: Reactome:REACT_113266
has db xref: Reactome:REACT_115264
has db xref: Reactome:REACT_28496
has db xref: Reactome:REACT_29504
has db xref: Reactome:REACT_32809
has db xref: Reactome:REACT_33982
has db xref: Reactome:REACT_6832
has db xref: Reactome:REACT_6944
has db xref: Reactome:REACT_82229
has db xref: Reactome:REACT_83190
has db xref: Reactome:REACT_83509
has db xref: Reactome:REACT_83772
has db xref: Reactome:REACT_84287
has db xref: Reactome:REACT_85456
has db xref: Reactome:REACT_85532
has db xref: Reactome:REACT_88074
has db xref: Reactome:REACT_91678
has db xref: Reactome:REACT_91780
has db xref: Reactome:REACT_99622
has db xref: UM-BBD_enzymeID:e0341
has exact synonym: 2-naphthylamine N-acetyltransferase activity
has exact synonym: 4-aminobiphenyl N-acetyltransferase activity
has exact synonym: acetyl CoA-arylamine N-acetyltransferase activity
has exact synonym: acetyl-CoA:arylamine N-acetyltransferase activity
has exact synonym: arylamine acetylase activity
has exact synonym: arylamine acetyltransferase activity
has exact synonym: beta-naphthylamine N-acetyltransferase activity
has exact synonym: indoleamine N-acetyltransferase activity
has exact synonym: p-aminosalicylate N-acetyltransferase activity
has OBO namespace: molecular_function
id: GO:0004060
in subset: gosubset prok
type: Class
subclass of: GO_0008080

arylformamidase activity
IAO_0000115: Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
has db xref: EC:3.5.1.9
has db xref: MetaCyc:ARYLFORMAMIDASE-RXN
has db xref: RHEA:13012
has db xref: Reactome:REACT_101177
has db xref: Reactome:REACT_101720
has db xref: Reactome:REACT_105730
has db xref: Reactome:REACT_106733
has db xref: Reactome:REACT_110747
has db xref: Reactome:REACT_1187
has db xref: Reactome:REACT_1804
has db xref: Reactome:REACT_31432
has db xref: Reactome:REACT_46660
has db xref: Reactome:REACT_97680
has exact synonym: aryl-formylamine amidohydrolase activity
has exact synonym: formylase activity
has exact synonym: formylkynureninase activity
has exact synonym: formylkynurenine formamidase activity
has exact synonym: kynurenine formamidase activity
has OBO namespace: molecular_function
has related synonym: formamidase I
has related synonym: formamidase II
id: GO:0004061
in subset: gosubset prok
type: Class
subclass of: GO_0016811

aryl sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
has broad synonym: arylsulfotransferase
has db xref: EC:2.8.2.1
has db xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN
has db xref: Reactome:REACT_101593
has db xref: Reactome:REACT_101626
has db xref: Reactome:REACT_103168
has db xref: Reactome:REACT_103360
has db xref: Reactome:REACT_103392
has db xref: Reactome:REACT_103811
has db xref: Reactome:REACT_104618
has db xref: Reactome:REACT_105302
has db xref: Reactome:REACT_105483
has db xref: Reactome:REACT_106988
has db xref: Reactome:REACT_107852
has db xref: Reactome:REACT_109219
has db xref: Reactome:REACT_112861
has db xref: Reactome:REACT_113420
has db xref: Reactome:REACT_113755
has db xref: Reactome:REACT_113826
has db xref: Reactome:REACT_114350
has db xref: Reactome:REACT_114511
has db xref: Reactome:REACT_114894
has db xref: Reactome:REACT_115246
has db xref: Reactome:REACT_115272
has db xref: Reactome:REACT_28338
has db xref: Reactome:REACT_28779
has db xref: Reactome:REACT_30659
has db xref: Reactome:REACT_31265
has db xref: Reactome:REACT_31366
has db xref: Reactome:REACT_32021
has db xref: Reactome:REACT_32963
has db xref: Reactome:REACT_33894
has db xref: Reactome:REACT_34807
has db xref: Reactome:REACT_6722
has db xref: Reactome:REACT_6740
has db xref: Reactome:REACT_6765
has db xref: Reactome:REACT_6855
has db xref: Reactome:REACT_6868
has db xref: Reactome:REACT_6897
has db xref: Reactome:REACT_6961
has db xref: Reactome:REACT_77729
has db xref: Reactome:REACT_78668
has db xref: Reactome:REACT_80310
has db xref: Reactome:REACT_80654
has db xref: Reactome:REACT_80880
has db xref: Reactome:REACT_81976
has db xref: Reactome:REACT_83825
has db xref: Reactome:REACT_83936
has db xref: Reactome:REACT_84713
has db xref: Reactome:REACT_87537
has db xref: Reactome:REACT_88863
has db xref: Reactome:REACT_89258
has db xref: Reactome:REACT_89426
has db xref: Reactome:REACT_90170
has db xref: Reactome:REACT_90269
has db xref: Reactome:REACT_90981
has db xref: Reactome:REACT_91386
has db xref: Reactome:REACT_91525
has db xref: Reactome:REACT_91946
has db xref: Reactome:REACT_92808
has db xref: Reactome:REACT_94928
has db xref: Reactome:REACT_95232
has exact synonym: 1-naphthol phenol sulfotransferase activity
has exact synonym: 2-naphtholsulfotransferase activity
has exact synonym: 3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity
has exact synonym: 4-nitrocatechol sulfokinase activity
has exact synonym: aryl sulphotransferase activity
has exact synonym: dopamine sulfotransferase activity
has exact synonym: p-nitrophenol sulfotransferase activity
has exact synonym: phenol sulfokinase activity
has exact synonym: phenol sulfotransferase activity
has exact synonym: ritodrine sulfotransferase activity
has OBO namespace: molecular_function
has related synonym: PST
has related synonym: sulfokinase activity
id: GO:0004062
in subset: gosubset prok
type: Class

aryldialkylphosphatase activity
IAO_0000115: Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
has broad synonym: A-esterase activity
has broad synonym: paraoxon hydrolase activity
has broad synonym: paraoxonase activity
has db xref: EC:3.1.8.1
has db xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN
has db xref: UM-BBD_enzymeID:e0054
has exact synonym: aryltriphosphatase activity
has exact synonym: aryltriphosphate dialkylphosphohydrolase activity
has exact synonym: organophosphate esterase activity
has exact synonym: organophosphate hydrolase activity
has exact synonym: organophosphorus acid anhydrase activity
has exact synonym: organophosphorus hydrolase activity
has exact synonym: paraoxon esterase activity
has exact synonym: phosphotriesterase activity
has exact synonym: pirimiphos-methyloxon esterase activity
has OBO namespace: molecular_function
has related synonym: OPH
has related synonym: esterase B1
has related synonym: esterase E4
id: GO:0004063
in subset: gosubset prok
type: Class
subclass of: GO_0016791

arylesterase activity
IAO_0000115: Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.
has broad synonym: A-esterase activity
has broad synonym: paraoxonase activity
has db xref: EC:3.1.1.2
has db xref: MetaCyc:ARYLESTERASE-RXN
has db xref: UM-BBD_reactionID:r0757
has narrow synonym: aromatic esterase
has narrow synonym: aryl-ester hydrolase
has OBO namespace: molecular_function
id: GO:0004064
in subset: gosubset prok
type: Class
subclass of: GO_0052689

arylsulfatase activity
IAO_0000115: Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.
has db xref: EC:3.1.6.1
has db xref: MetaCyc:ARYLSULFAT-RXN
has exact synonym: 4-methylumbelliferyl sulfatase activity
has exact synonym: aryl-sulfate sulfohydrolase activity
has exact synonym: aryl-sulfate sulphohydrolase activity
has exact synonym: aryl-sulphate sulphohydrolase activity
has exact synonym: arylsulfohydrolase activity
has exact synonym: arylsulphatase activity
has exact synonym: estrogen sulfatase activity
has exact synonym: nitrocatechol sulfatase activity
has exact synonym: p-nitrophenyl sulfatase activity
has exact synonym: phenolsulfatase activity
has exact synonym: phenylsulfatase activity
has OBO namespace: molecular_function
has related synonym: sulfatase activity
id: GO:0004065
in subset: gosubset prok
type: Class
subclass of: GO_0008484

asparagine synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
has db xref: EC:6.3.5.4
has db xref: MetaCyc:ASNSYNB-RXN
has db xref: RHEA:24877
has db xref: Reactome:REACT_102336
has db xref: Reactome:REACT_107530
has db xref: Reactome:REACT_109835
has db xref: Reactome:REACT_112740
has db xref: Reactome:REACT_113607
has db xref: Reactome:REACT_114769
has db xref: Reactome:REACT_277
has db xref: Reactome:REACT_30477
has db xref: Reactome:REACT_31824
has db xref: Reactome:REACT_31879
has db xref: Reactome:REACT_34512
has db xref: Reactome:REACT_80145
has db xref: Reactome:REACT_80719
has db xref: Reactome:REACT_81036
has db xref: Reactome:REACT_86665
has db xref: Reactome:REACT_86705
has db xref: Reactome:REACT_91813
has db xref: Reactome:REACT_94577
has db xref: Reactome:REACT_95520
has db xref: Reactome:REACT_97491
has exact synonym: AS-B activity
has exact synonym: L-aspartate:L-glutamine amido-ligase (AMP-forming)
has exact synonym: asparagine synthase (glutamine-hydrolysing)
has exact synonym: asparagine synthetase (glutamine-hydrolysing)
has exact synonym: asparagine synthetase (glutamine-hydrolyzing) activity
has exact synonym: asparagine synthetase B activity
has exact synonym: glutamine-dependent asparagine synthetase activity
has OBO namespace: molecular_function
has related synonym: AS
id: GO:0004066
in subset: gosubset prok
type: Class
subclass of: GO_0016884

asparaginase activity
IAO_0000115: Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
has db xref: EC:3.5.1.1
has db xref: MetaCyc:ASPARAGHYD-RXN
has db xref: RHEA:21019
has exact synonym: L-asparaginase activity
has exact synonym: L-asparagine amidohydrolase activity
has exact synonym: alpha-asparaginase activity
has exact synonym: colaspase activity
has exact synonym: leunase activity
has OBO namespace: molecular_function
has related synonym: asparaginase II
has related synonym: crasnitin
has related synonym: elspar
id: GO:0004067
in subset: gosubset prok
type: Class
subclass of: GO_0016811

aspartate 1-decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-aspartate = beta-alanine + CO2.
has broad synonym: aspartic alpha-decarboxylase
has db xref: EC:4.1.1.11
has db xref: MetaCyc:ASPDECARBOX-RXN
has db xref: MetaCyc:PWY-5155
has db xref: RHEA:19500
has exact synonym: L-aspartate 1-carboxy-lyase (beta-alanine-forming)
has exact synonym: L-aspartate 1-carboxy-lyase activity
has exact synonym: L-aspartate alpha-decarboxylase activity
has exact synonym: aspartate alpha-decarboxylase activity
has OBO namespace: molecular_function
id: GO:0004068
in subset: gosubset prok
type: Class
subclass of: GO_0016831

L-aspartate:2-oxoglutarate aminotransferase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
has broad synonym: L-aspartate transaminase activity
has broad synonym: L-aspartic aminotransferase activity
has broad synonym: aspartate aminotransferase activity
has broad synonym: aspartate transaminase activity
has broad synonym: aspartic acid aminotransferase activity
has broad synonym: aspartic aminotransferase activity
has broad synonym: aspartyl aminotransferase activity
has db xref: EC:2.6.1.1
has db xref: MetaCyc:ASPAMINOTRANS-RXN
has db xref: Reactome:REACT_100250
has db xref: Reactome:REACT_100619
has db xref: Reactome:REACT_101098
has db xref: Reactome:REACT_102229
has db xref: Reactome:REACT_102338
has db xref: Reactome:REACT_104061
has db xref: Reactome:REACT_104242
has db xref: Reactome:REACT_104365
has db xref: Reactome:REACT_104429
has db xref: Reactome:REACT_105965
has db xref: Reactome:REACT_106583
has db xref: Reactome:REACT_107401
has db xref: Reactome:REACT_107422
has db xref: Reactome:REACT_107443
has db xref: Reactome:REACT_107885
has db xref: Reactome:REACT_108823
has db xref: Reactome:REACT_109829
has db xref: Reactome:REACT_110632
has db xref: Reactome:REACT_110701
has db xref: Reactome:REACT_112410
has db xref: Reactome:REACT_112542
has db xref: Reactome:REACT_113079
has db xref: Reactome:REACT_115016
has db xref: Reactome:REACT_115018
has db xref: Reactome:REACT_115062
has db xref: Reactome:REACT_115765
has db xref: Reactome:REACT_115783
has db xref: Reactome:REACT_115863
has db xref: Reactome:REACT_115958
has db xref: Reactome:REACT_1558
has db xref: Reactome:REACT_1632
has db xref: Reactome:REACT_2078
has db xref: Reactome:REACT_280
has db xref: Reactome:REACT_28947
has db xref: Reactome:REACT_28965
has db xref: Reactome:REACT_31038
has db xref: Reactome:REACT_31146
has db xref: Reactome:REACT_32675
has db xref: Reactome:REACT_34387
has db xref: Reactome:REACT_34754
has db xref: Reactome:REACT_67549
has db xref: Reactome:REACT_77562
has db xref: Reactome:REACT_77740
has db xref: Reactome:REACT_79228
has db xref: Reactome:REACT_80018
has db xref: Reactome:REACT_80569
has db xref: Reactome:REACT_80879
has db xref: Reactome:REACT_82087
has db xref: Reactome:REACT_82808
has db xref: Reactome:REACT_82944
has db xref: Reactome:REACT_83266
has db xref: Reactome:REACT_84706
has db xref: Reactome:REACT_84867
has db xref: Reactome:REACT_85085
has db xref: Reactome:REACT_86159
has db xref: Reactome:REACT_86367
has db xref: Reactome:REACT_87626
has db xref: Reactome:REACT_89219
has db xref: Reactome:REACT_89337
has db xref: Reactome:REACT_89398
has db xref: Reactome:REACT_89436
has db xref: Reactome:REACT_90427
has db xref: Reactome:REACT_91145
has db xref: Reactome:REACT_91482
has db xref: Reactome:REACT_91798
has db xref: Reactome:REACT_92155
has db xref: Reactome:REACT_92692
has db xref: Reactome:REACT_93130
has db xref: Reactome:REACT_93870
has db xref: Reactome:REACT_94071

aspartate carbamoyltransferase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
has db xref: EC:2.1.3.2
has db xref: KEGG:R01397
has db xref: MetaCyc:ASPCARBTRANS-RXN
has db xref: RHEA:20016
has db xref: Reactome:REACT_103105
has db xref: Reactome:REACT_105018
has db xref: Reactome:REACT_107363
has db xref: Reactome:REACT_110200
has db xref: Reactome:REACT_115976
has db xref: Reactome:REACT_1965
has db xref: Reactome:REACT_30409
has db xref: Reactome:REACT_30529
has db xref: Reactome:REACT_80965
has db xref: Reactome:REACT_89217
has db xref: Reactome:REACT_90716
has db xref: Reactome:REACT_91724
has db xref: Reactome:REACT_96047
has db xref: Reactome:REACT_98356
has db xref: Reactome:REACT_98452
has exact synonym: ATCase activity
has exact synonym: L-aspartate transcarbamoylase activity
has exact synonym: L-aspartate transcarbamylase activity
has exact synonym: aspartate carbamyltransferase activity
has exact synonym: aspartate transcarbamoylase activity
has exact synonym: aspartate transcarbamylase activity
has exact synonym: aspartic acid transcarbamoylase activity
has exact synonym: aspartic carbamyltransferase activity
has exact synonym: aspartic transcarbamylase activity
has exact synonym: carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
has exact synonym: carbamoylaspartotranskinase activity
has exact synonym: carbamylaspartotranskinase activity
has OBO namespace: molecular_function
id: GO:0004070
in subset: gosubset prok
type: Class
subclass of: GO_0016743

aspartate-ammonia ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.
has db xref: EC:6.3.1.1
has db xref: MetaCyc:ASNSYNA-RXN
has db xref: RHEA:11375
has exact synonym: L-asparagine synthetase activity
has exact synonym: L-aspartate:ammonia ligase (AMP-forming)
has exact synonym: asparagine synthetase activity
has OBO namespace: molecular_function
id: GO:0004071
in subset: gosubset prok
type: Class
subclass of: GO_0016211

aspartate kinase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+).
has db xref: EC:2.7.2.4
has db xref: KEGG:R00480
has db xref: MetaCyc:ASPARTATEKIN-RXN
has db xref: RHEA:23779
has exact synonym: ATP:L-aspartate 4-phosphotransferase activity
has exact synonym: aspartic kinase activity
has exact synonym: aspartokinase activity
has exact synonym: beta-aspartokinase activity
has OBO namespace: molecular_function
id: GO:0004072
in subset: gosubset prok
type: Class
subclass of: GO_0016774
subclass of: GO_0019202

aspartate-semialdehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH.
has db xref: EC:1.2.1.11
has db xref: KEGG:R02291
has db xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
has db xref: RHEA:24287
has exact synonym: ASA dehydrogenase activity
has exact synonym: L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
has exact synonym: L-aspartate-beta-semialdehyde dehydrogenase activity
has exact synonym: L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)
has exact synonym: aspartate semialdehyde dehydrogenase activity
has exact synonym: aspartic beta-semialdehyde dehydrogenase activity
has exact synonym: aspartic semialdehyde dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004073
in subset: gosubset prok
type: Class
subclass of: GO_0016620

biliverdin reductase activity
IAO_0000115: Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.
has db xref: EC:1.3.1.24
has db xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN
has db xref: Reactome:REACT_22177
has db xref: Reactome:REACT_31500
has db xref: Reactome:REACT_32959
has db xref: Reactome:REACT_34270
has db xref: Reactome:REACT_81350
has db xref: Reactome:REACT_82319
has db xref: Reactome:REACT_88875
has db xref: Reactome:REACT_89833
has db xref: Reactome:REACT_91067
has db xref: Reactome:REACT_91178
has db xref: Reactome:REACT_93458
has exact synonym: bilirubin:NAD(P)+ oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004074
type: Class
subclass of: GO_0016628

biotin carboxylase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.
has db xref: EC:6.3.4.14
has db xref: MetaCyc:BIOTIN-CARBOXYL-RXN
has exact synonym: biotin carboxylase (component of acetyl CoA carboxylase) activity
has exact synonym: biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity
has OBO namespace: molecular_function
id: GO:0004075
in subset: gosubset prok
type: Class
subclass of: GO_0016879

biotin synthase activity
IAO_0000115: Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
has db xref: EC:2.8.1.6
has db xref: KEGG:R01078
has db xref: MetaCyc:2.8.1.6-RXN
has db xref: RHEA:22063
has exact synonym: biotin synthetase activity
has exact synonym: dethiobiotin:sulfur sulfurtransferase activity
has OBO namespace: molecular_function
id: GO:0004076
in subset: gosubset prok
type: Class
subclass of: GO_0016783
subclass of: GO_0070283

biotin-[acetyl-CoA-carboxylase] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).
has broad synonym: biotin-acetyl-CoA carboxylase synthetase
has db xref: EC:6.3.4.15
has db xref: MetaCyc:BIOTINLIG-RXN
has exact synonym: acetyl CoA holocarboxylase synthetase activity
has exact synonym: acetyl coenzyme A holocarboxylase synthetase activity
has exact synonym: acetyl-CoA carboxylase biotin holoenzyme synthetase activity
has exact synonym: biotin holoenzyme synthetase activity
has exact synonym: biotin--[acetyl-CoA carboxylase] synthetase activity
has exact synonym: biotin-acetyl coenzyme A carboxylase synthetase activity
has exact synonym: biotin-acetyl-CoA-carboxylase ligase activity
has exact synonym: biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has exact synonym: biotin:apocarboxylase ligase activity
has OBO namespace: molecular_function
has related synonym: HCS
has related synonym: biotin--protein ligase activity
id: GO:0004077
in subset: gosubset prok
type: Class
subclass of: GO_0018271

biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).
has broad synonym: biotin-methylcrotonoyl-CoA-carboxylase synthetase
has db xref: EC:6.3.4.11
has db xref: MetaCyc:6.3.4.11-RXN
has exact synonym: beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity
has exact synonym: biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity
has exact synonym: biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity
has exact synonym: biotin-methylcrotonoyl-CoA-carboxylase ligase activity
has exact synonym: biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has exact synonym: holocarboxylase-synthetase activity
has OBO namespace: molecular_function
id: GO:0004078
type: Class
subclass of: GO_0018271

biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).
has broad synonym: biotin-methylmalonyl-CoA-carboxyltransferase synthetase
has db xref: EC:6.3.4.9
has db xref: MetaCyc:6.3.4.9-RXN
has exact synonym: biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity
has exact synonym: biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity
has exact synonym: biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity
has exact synonym: biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity
has exact synonym: biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity
has exact synonym: biotin-methylmalonyl-CoA-carboxyltransferase ligase activity
has exact synonym: biotin-methylmalonyl-CoA-carboxytransferase ligase activity
has exact synonym: biotin-methylmalonyl-CoA-carboxytransferase synthetase activity
has exact synonym: biotin-transcarboxylase synthetase activity
has exact synonym: biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)
has exact synonym: biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)
has exact synonym: methylmalonyl coenzyme A holotranscarboxylase synthetase activity
has OBO namespace: molecular_function
id: GO:0004079
type: Class
subclass of: GO_0018271

biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).
has db xref: EC:6.3.4.10
has db xref: MetaCyc:6.3.4.10-RXN
has exact synonym: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity
has exact synonym: biotin-propionyl coenzyme A carboxylase synthetase activity
has exact synonym: biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity
has exact synonym: biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity
has exact synonym: biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has exact synonym: holocarboxylase synthetase activity
has exact synonym: propionyl coenzyme A holocarboxylase synthetase activity
has exact synonym: propionyl-CoA holocarboxylase synthetase activity
has OBO namespace: molecular_function
id: GO:0004080
type: Class
subclass of: GO_0018271

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
IAO_0000115: Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate.
has broad synonym: Ap(4)A hydrolase activity
has broad synonym: Ap(4)Aase activity
has broad synonym: Ap4A hydrolase activity
has broad synonym: Ap4Aase activity
has db xref: EC:3.6.1.17
has db xref: MetaCyc:3.6.1.17-RXN
has db xref: RHEA:22487
has exact synonym: 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
has exact synonym: P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
has exact synonym: diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity
has exact synonym: diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity
has exact synonym: diadenosine P1,P4-tetraphosphatase activity
has exact synonym: dinucleoside tetraphosphatase activity
has exact synonym: dinucleosidetetraphosphatase (asymmetrical) activity
has narrow synonym: bis(5'-adenosyl)-tetraphosphatase activity
has narrow synonym: bis(5'-guanosyl)-tetraphosphatase activity
has narrow synonym: diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase
has narrow synonym: diadenosinetetraphosphatase (asymmetrical) activity
has narrow synonym: diguanosinetetraphosphatase (asymmetrical) activity
has OBO namespace: molecular_function
id: GO:0004081
in subset: gosubset prok
type: Class
subclass of: GO_0008796

bisphosphoglycerate mutase activity
IAO_0000115: Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
has broad synonym: bisphosphoglyceromutase
has db xref: EC:5.4.2.4
has db xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN
has db xref: RHEA:17768
has exact synonym: 2,3-bisphosphoglycerate mutase activity
has exact synonym: 2,3-bisphosphoglycerate synthase activity
has exact synonym: 2,3-diphosphoglycerate mutase activity
has exact synonym: 2,3-diphosphoglycerate synthase activity
has exact synonym: 2,3-diphosphoglyceromutase activity
has exact synonym: 3-phospho-D-glycerate 1,2-phosphomutase activity
has exact synonym: BPGM activity
has exact synonym: biphosphoglycerate synthase activity
has exact synonym: bisphosphoglycerate synthase activity
has exact synonym: diphosphoglycerate mutase activity
has exact synonym: diphosphoglyceric mutase activity
has exact synonym: diphosphoglyceromutase activity
has exact synonym: glycerate phosphomutase activity
has OBO namespace: molecular_function
has related synonym: DPGM
id: GO:0004082
type: Class
subclass of: GO_0016868

bisphosphoglycerate 2-phosphatase activity
IAO_0000115: Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
has broad synonym: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity
has db xref: EC:3.1.3.13
has db xref: KEGG:R01516
has db xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN
has db xref: RHEA:21907
has OBO namespace: molecular_function
id: GO:0004083
type: Class
subclass of: GO_0034416

branched-chain-amino-acid transaminase activity
IAO_0000115: Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.
has db xref: EC:2.6.1.42
has db xref: Reactome:REACT_103033
has db xref: Reactome:REACT_104255
has db xref: Reactome:REACT_109061
has db xref: Reactome:REACT_112447
has db xref: Reactome:REACT_1136
has db xref: Reactome:REACT_2034
has db xref: Reactome:REACT_21283
has db xref: Reactome:REACT_21409
has db xref: Reactome:REACT_29623
has db xref: Reactome:REACT_31174
has db xref: Reactome:REACT_31737
has db xref: Reactome:REACT_31924
has db xref: Reactome:REACT_32127
has db xref: Reactome:REACT_76927
has db xref: Reactome:REACT_81549
has db xref: Reactome:REACT_84147
has db xref: Reactome:REACT_85686
has db xref: Reactome:REACT_87300
has db xref: Reactome:REACT_87826
has db xref: Reactome:REACT_89738
has db xref: Reactome:REACT_93129
has db xref: Reactome:REACT_95349
has db xref: Reactome:REACT_95545
has db xref: Reactome:REACT_96261
has db xref: Reactome:REACT_96398
has db xref: Reactome:REACT_97251
has db xref: Reactome:REACT_97510
has db xref: Reactome:REACT_97898
has db xref: Reactome:REACT_99130
has db xref: Reactome:REACT_99998
has exact synonym: L-branched chain amino acid aminotransferase activity
has exact synonym: branched-chain amino acid aminotransferase activity
has exact synonym: branched-chain amino acid-glutamate transaminase activity
has exact synonym: branched-chain aminotransferase activity
has exact synonym: branched-chain-amino-acid:2-oxoglutarate aminotransferase activity
has exact synonym: glutamate-branched-chain amino acid transaminase activity
has OBO namespace: molecular_function
has related synonym: transaminase B activity
id: GO:0004084
in subset: gosubset prok
type: Class
subclass of: GO_0008483

butyryl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.
has db xref: EC:1.3.8.1
has db xref: KEGG:R01178
has db xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN
has db xref: UM-BBD_reactionID:r0013
has exact synonym: 3-hydroxyacyl CoA reductase activity
has exact synonym: butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity
has exact synonym: butanoyl-CoA:acceptor 2,3-oxidoreductase activity
has exact synonym: butyryl coenzyme A dehydrogenase activity
has exact synonym: butyryl dehydrogenase activity
has exact synonym: enoyl-coenzyme A reductase activity
has exact synonym: ethylene reductase activity
has exact synonym: short-chain acyl CoA dehydrogenase activity
has exact synonym: short-chain acyl-coenzyme A dehydrogenase activity
has exact synonym: unsaturated acyl coenzyme A reductase activity
has OBO namespace: molecular_function
has related synonym: short-chain-acyl-CoA dehydrogenase activity
has related synonym: unsaturated acyl-CoA reductase activity
id: GO:0004085
in subset: gosubset prok
type: Class
subclass of: GO_0052890

carbamoyl-phosphate synthase activity
IAO_0000115: OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate.
consider: GO:0004087
consider: GO:0004088
has exact synonym: carbamoyl phosphate synthase activity
has OBO namespace: molecular_function
id: GO:0004086
type: Class
comment: This term was made obsolete because it is a grouping term based on name, rather than on function.
deprecated: true

carbamoyl-phosphate synthase (ammonia) activity
IAO_0000115: Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate.
has db xref: EC:6.3.4.16
has db xref: KEGG:R00149
has db xref: MetaCyc:6.3.4.16-RXN
has db xref: RHEA:10627
has db xref: Reactome:REACT_104425
has db xref: Reactome:REACT_112052
has db xref: Reactome:REACT_112191
has db xref: Reactome:REACT_112781
has db xref: Reactome:REACT_1701
has db xref: Reactome:REACT_28657
has db xref: Reactome:REACT_32408
has db xref: Reactome:REACT_32830
has db xref: Reactome:REACT_45108
has db xref: Reactome:REACT_78285
has db xref: Reactome:REACT_79612
has db xref: Reactome:REACT_81920
has db xref: Reactome:REACT_87223
has db xref: Reactome:REACT_89630
has exact synonym: carbamoyl phosphate synthase (ammonia) activity
has exact synonym: carbamoyl-phosphate synthetase (ammonia) activity
has exact synonym: carbamoyl-phosphate synthetase I activity
has exact synonym: carbamoylphosphate synthase (ammonia)
has exact synonym: carbamoylphosphate synthase activity
has exact synonym: carbamoylphosphate synthetase (ammonia) activity
has exact synonym: carbamylphosphate synthetase activity
has exact synonym: carbmoylphosphate synthetase activity
has exact synonym: carbon-dioxide--ammonia ligase activity
has exact synonym: carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
has narrow synonym: CPS I activity
has OBO namespace: molecular_function
has related synonym: carbamylphosphate synthetase I
id: GO:0004087
in subset: gosubset prok
type: Class
subclass of: GO_0016879

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
has db xref: EC:6.3.5.5
has db xref: MetaCyc:CARBPSYN-RXN
has db xref: RHEA:24654
has db xref: Reactome:REACT_102934
has db xref: Reactome:REACT_115736
has db xref: Reactome:REACT_28976
has db xref: Reactome:REACT_29452
has db xref: Reactome:REACT_30926
has db xref: Reactome:REACT_478
has db xref: Reactome:REACT_77966
has db xref: Reactome:REACT_79566
has db xref: Reactome:REACT_83511
has db xref: Reactome:REACT_86599
has db xref: Reactome:REACT_86815
has db xref: Reactome:REACT_88920
has db xref: Reactome:REACT_89432
has db xref: Reactome:REACT_94822
has db xref: Reactome:REACT_96943
has exact synonym: CPS activity
has exact synonym: GD-CPSase activity
has exact synonym: carbamoyl phosphate synthase (glutamine-hydrolyzing) activity
has exact synonym: carbamoyl phosphate synthetase activity
has exact synonym: carbamoyl-phosphate synthase (glutamine-hydrolysing) activity
has exact synonym: carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity
has exact synonym: carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity
has exact synonym: carbamoylphosphate synthetase II activity
has exact synonym: carbamyl phosphate synthetase (glutamine) activity
has exact synonym: carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
has exact synonym: glutamine-dependent carbamoyl-phosphate synthase activity
has exact synonym: glutamine-dependent carbamyl phosphate synthetase activity
has exact synonym: hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
has OBO namespace: molecular_function
id: GO:0004088
in subset: gosubset prok
type: Class
subclass of: GO_0016884

carbonate dehydratase activity
IAO_0000115: Catalysis of the reaction: H2CO3 = CO2 + H2O.
has db xref: EC:4.2.1.1
has db xref: MetaCyc:CARBODEHYDRAT-RXN
has db xref: RHEA:10751
has exact synonym: anhydrase activity
has exact synonym: carbonate anhydrase activity
has exact synonym: carbonate hydro-lyase (carbon-dioxide-forming)
has exact synonym: carbonate hydro-lyase activity
has exact synonym: carbonic acid anhydrase activity
has exact synonym: carbonic anhydrase activity
has exact synonym: carbonic dehydratase activity
has exact synonym: carboxyanhydrase activity
has OBO namespace: molecular_function
has related synonym: carbonic anhydrase A
id: GO:0004089
in subset: gosubset prok
type: Class
subclass of: GO_0016836

carbonyl reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
has db xref: EC:1.1.1.184
has db xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN
has db xref: RHEA:19260
has exact synonym: NADPH-dependent carbonyl reductase activity
has exact synonym: NADPH2-dependent carbonyl reductase activity
has exact synonym: carbonyl reductase activity
has exact synonym: nonspecific NADPH-dependent carbonyl reductase activity
has exact synonym: secondary-alcohol:NADP+ oxidoreductase activity
has narrow synonym: prostaglandin 9-ketoreductase activity
has narrow synonym: xenobiotic ketone reductase activity
has OBO namespace: molecular_function
has related synonym: ALR3
has related synonym: aldehyde reductase 1
has related synonym: aldehyde reductase I activity
id: GO:0004090
in subset: gosubset prok
type: Class
subclass of: GO_0016616

carboxylesterase activity
IAO_0000115: Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion.
has alternative id: GO:0004302
has alternative id: GO:0004759
has alternative id: GO:0016789
has db xref: EC:3.1.1.1
has db xref: KEGG:R00630
has db xref: MetaCyc:CARBOXYLESTERASE-RXN
has db xref: UM-BBD_reactionID:r1025
has exact synonym: ali-esterase activity
has exact synonym: alpha-carboxylesterase activity
has exact synonym: carboxyesterase activity
has exact synonym: carboxylate esterase activity
has exact synonym: carboxylic acid esterase activity
has exact synonym: carboxylic esterase activity
has exact synonym: nonspecific carboxylesterase activity
has exact synonym: serine esterase activity
has narrow synonym: cocaine esterase activity
has narrow synonym: procaine esterase activity
has narrow synonym: triacetin esterase
has narrow synonym: vitamin A esterase
has OBO namespace: molecular_function
has related synonym: Ali-esterase activity
has related synonym: B-esterase activity
has related synonym: carboxyl ester hydrolase activity
has related synonym: carboxylic ester hydrolase activity
has related synonym: esterase A
has related synonym: esterase B
id: GO:0004091
in subset: gosubset prok
type: Class
subclass of: GO_0052689

carnitine O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.
has alternative id: GO:0004093
has alternative id: GO:0004094
has db xref: EC:2.3.1.7
has db xref: KEGG:R02396
has db xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN
has db xref: RHEA:21139
has db xref: Reactome:REACT_106381
has db xref: Reactome:REACT_107669
has db xref: Reactome:REACT_16949
has db xref: Reactome:REACT_16977
has db xref: Reactome:REACT_32144
has db xref: Reactome:REACT_34276
has db xref: Reactome:REACT_34588
has db xref: Reactome:REACT_34633
has db xref: Reactome:REACT_34692
has db xref: Reactome:REACT_77010
has db xref: Reactome:REACT_77298
has db xref: Reactome:REACT_78054
has db xref: Reactome:REACT_79550
has db xref: Reactome:REACT_85497
has db xref: Reactome:REACT_87499
has db xref: Reactome:REACT_87701
has db xref: Reactome:REACT_90661
has db xref: Reactome:REACT_92700
has db xref: Reactome:REACT_94633
has db xref: Reactome:REACT_98210
has exact synonym: acetyl-CoA-carnitine O-acetyltransferase activity
has exact synonym: acetyl-CoA:carnitine O-acetyltransferase activity
has exact synonym: acetylcarnitine transferase activity
has exact synonym: carnitine acetyl coenzyme A transferase activity
has exact synonym: carnitine acetylase activity
has exact synonym: carnitine acetyltransferase activity
has exact synonym: carnitine-acetyl-CoA transferase activity
has narrow synonym: carnitine O-acetyltransferase I activity
has narrow synonym: carnitine O-acetyltransferase II activity
has OBO namespace: molecular_function
has related synonym: CATC
id: GO:0004092
in subset: gosubset prok
type: Class
subclass of: GO_0016406
subclass of: GO_0016413

carnitine O-palmitoyltransferase activity
IAO_0000115: Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
has db xref: EC:2.3.1.21
has db xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN
has db xref: RHEA:12664
has db xref: Reactome:REACT_106987
has db xref: Reactome:REACT_108163
has db xref: Reactome:REACT_11133
has db xref: Reactome:REACT_11185
has db xref: Reactome:REACT_30467
has db xref: Reactome:REACT_33707
has db xref: Reactome:REACT_34534
has db xref: Reactome:REACT_77063
has db xref: Reactome:REACT_78400
has db xref: Reactome:REACT_78721
has db xref: Reactome:REACT_83067
has db xref: Reactome:REACT_83898
has db xref: Reactome:REACT_86504
has db xref: Reactome:REACT_86687
has db xref: Reactome:REACT_87240
has db xref: Reactome:REACT_88030
has db xref: Reactome:REACT_88075
has db xref: Reactome:REACT_89612
has db xref: Reactome:REACT_92120
has db xref: Reactome:REACT_94774
has db xref: Reactome:REACT_95110
has db xref: Reactome:REACT_95133
has db xref: Reactome:REACT_95851
has db xref: Reactome:REACT_99269
has exact synonym: L-carnitine palmitoyltransferase activity
has exact synonym: acylcarnitine transferase activity
has exact synonym: carnitine palmitoyltransferase activity
has exact synonym: outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity
has exact synonym: palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity
has exact synonym: palmitoylcarnitine transferase activity
has OBO namespace: molecular_function
has related synonym: CPT
has related synonym: CPT I (outer membrane carnitine palmitoyl transferase)
has related synonym: CPT-A
has related synonym: CPT-B
has related synonym: CPTi
has related synonym: CPTo
has related synonym: carnitine palmitoyltransferase I
has related synonym: carnitine palmitoyltransferase II
has related synonym: carnitine palmitoyltransferase-A
id: GO:0004095
type: Class
subclass of: GO_0016406
subclass of: GO_0016416

catalase activity
IAO_0000115: Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
has alternative id: GO:0016952
has alternative id: GO:0016953
has db xref: EC:1.11.1.6
has db xref: MetaCyc:CATAL-RXN
has db xref: RHEA:20312
has db xref: Reactome:REACT_101648
has db xref: Reactome:REACT_108235
has db xref: Reactome:REACT_112160
has db xref: Reactome:REACT_30681
has db xref: Reactome:REACT_30704
has db xref: Reactome:REACT_30957
has db xref: Reactome:REACT_615
has db xref: Reactome:REACT_79013
has db xref: Reactome:REACT_79757
has db xref: Reactome:REACT_85074
has db xref: Reactome:REACT_85170
has db xref: Reactome:REACT_87638
has db xref: Reactome:REACT_89864
has db xref: Reactome:REACT_90743
has db xref: Reactome:REACT_91037
has db xref: Reactome:REACT_91307
has db xref: Reactome:REACT_96832
has db xref: UM-BBD_enzymeID:e0834
has exact synonym: caperase activity
has exact synonym: catalase reaction
has exact synonym: catalase-peroxidase activity
has exact synonym: equilase activity
has exact synonym: hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity
has exact synonym: optidase activity
has narrow synonym: bacterial catalase-peroxidase activity
has narrow synonym: haem catalase activity
has narrow synonym: heme catalase activity
has narrow synonym: manganese catalase activity
has OBO namespace: molecular_function
has related synonym: CAT
id: GO:0004096
in subset: gosubset prok
type: Class
subclass of: GO_0004601

catechol oxidase activity
IAO_0000115: Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O.
has broad synonym: catecholase
has broad synonym: dopa oxidase
has broad synonym: o-diphenol oxidoreductase
has broad synonym: o-diphenol:oxygen oxidoreductase
has broad synonym: phenolase activity
has broad synonym: pyrocatechol oxidase
has broad synonym: tyrosinase activity
has db xref: EC:1.10.3.1
has db xref: MetaCyc:CATECHOL-OXIDASE-RXN
has db xref: RHEA:21635
has exact synonym: 1,2-benzenediol:oxygen oxidoreductase activity
has exact synonym: diphenol oxidase activity
has exact synonym: o-diphenolase activity
has exact synonym: polyphenol oxidase activity
has OBO namespace: molecular_function
id: GO:0004097
in subset: gosubset prok
type: Class
comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'.
subclass of: GO_0016682

cerebroside-sulfatase activity
IAO_0000115: Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.
has db xref: EC:3.1.6.8
has db xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN
has db xref: Reactome:REACT_115556
has exact synonym: arylsulfatase A activity
has exact synonym: cerebroside sulfate sulfatase activity
has exact synonym: cerebroside-3-sulfate 3-sulfohydrolase activity
has exact synonym: cerebroside-sulphatase activity
has OBO namespace: molecular_function
id: GO:0004098
in subset: gosubset prok
type: Class
subclass of: GO_0008484

chitin deacetylase activity
IAO_0000115: Catalysis of the reaction: chitin + H2O = chitosan + acetate.
has db xref: EC:3.5.1.41
has db xref: MetaCyc:CHITIN-DEACETYLASE-RXN
has db xref: RHEA:10467
has exact synonym: chitin amidohydrolase activity
has OBO namespace: molecular_function
id: GO:0004099
in subset: gosubset prok
type: Class
subclass of: GO_0016811
subclass of: GO_0019213

chitin synthase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).
has db xref: EC:2.4.1.16
has db xref: MetaCyc:CHITIN-SYNTHASE-RXN
has exact synonym: UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity
has exact synonym: chitin synthetase activity
has exact synonym: chitin-UDP N-acetylglucosaminyltransferase activity
has exact synonym: chitin-UDP acetyl-glucosaminyl transferase activity
has exact synonym: chitin-uridine diphosphate acetylglucosaminyltransferase activity
has exact synonym: trans-N-acetylglucosaminosylase activity
has OBO namespace: molecular_function
id: GO:0004100
in subset: gosubset prok
type: Class
subclass of: GO_0008375

choline O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
has db xref: EC:2.3.1.6
has db xref: KEGG:R01023
has db xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN
has db xref: RHEA:18824
has db xref: Reactome:REACT_105936
has db xref: Reactome:REACT_108136
has db xref: Reactome:REACT_109278
has db xref: Reactome:REACT_15484
has db xref: Reactome:REACT_29952
has db xref: Reactome:REACT_31186
has db xref: Reactome:REACT_77093
has db xref: Reactome:REACT_87316
has db xref: Reactome:REACT_94484
has db xref: Reactome:REACT_96109
has db xref: Reactome:REACT_97062
has db xref: Reactome:REACT_98162
has exact synonym: CHOACTase activity
has exact synonym: acetyl-CoA:choline O-acetyltransferase activity
has exact synonym: choline acetylase activity
has exact synonym: choline acetyltransferase activity
has OBO namespace: molecular_function
id: GO:0004102
in subset: gosubset prok
type: Class
subclass of: GO_0016413

choline kinase activity
IAO_0000115: Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
has db xref: EC:2.7.1.32
has db xref: KEGG:R01021
has db xref: MetaCyc:CHOLINE-KINASE-RXN
has db xref: RHEA:12840
has exact synonym: ATP:choline phosphotransferase activity
has exact synonym: choline kinase (phosphorylating)
has exact synonym: choline phosphokinase activity
has exact synonym: choline-ethanolamine kinase activity
has OBO namespace: molecular_function
id: GO:0004103
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

cholinesterase activity
IAO_0000115: Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
has db xref: EC:3.1.1.8
has db xref: MetaCyc:CHOLINESTERASE-RXN
has db xref: RHEA:21967
has exact synonym: BtChoEase activity
has exact synonym: acylcholine acylhydrolase activity
has exact synonym: anticholineesterase activity
has exact synonym: benzoylcholinesterase activity
has exact synonym: butyrylcholine esterase activity
has exact synonym: butyrylcholinesterase activity
has exact synonym: choline esterase II (unspecific) activity
has exact synonym: choline esterase activity
has exact synonym: non-specific cholinesterase activity
has exact synonym: propionylcholinesterase activity
has exact synonym: pseudocholinesterase activity
has OBO namespace: molecular_function
id: GO:0004104
in subset: gosubset prok
type: Class
subclass of: GO_0052689

choline-phosphate cytidylyltransferase activity
IAO_0000115: Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.
has db xref: EC:2.7.7.15
has db xref: MetaCyc:2.7.7.15-RXN
has db xref: RHEA:19000
has exact synonym: CDP-choline pyrophosphorylase activity
has exact synonym: CDP-choline synthetase activity
has exact synonym: CTP-phosphocholine cytidylyltransferase activity
has exact synonym: CTP:choline-phosphate cytidylyltransferase activity
has exact synonym: CTP:phosphocholine cytidylyltransferase activity
has exact synonym: CTP:phosphorylcholine cytidylyltransferase activity
has exact synonym: choline phosphate cytidylyltransferase activity
has exact synonym: cytidine diphosphocholine pyrophosphorylase activity
has exact synonym: phosphocholine cytidylyltransferase activity
has exact synonym: phosphorylcholine cytidylyltransferase activity
has exact synonym: phosphorylcholine transferase activity
has exact synonym: phosphorylcholine:CTP cytidylyltransferase activity
has OBO namespace: molecular_function
id: GO:0004105
in subset: gosubset prok
type: Class
subclass of: GO_0070567

chorismate mutase activity
IAO_0000115: Catalysis of the reaction: chorismate = prephenate.
has broad synonym: hydroxyphenylpyruvate synthase activity
has db xref: EC:5.4.99.5
has db xref: KEGG:R01715
has db xref: MetaCyc:CHORISMATEMUT-RXN
has db xref: RHEA:13900
has exact synonym: chorismate pyruvatemutase activity
has OBO namespace: molecular_function
id: GO:0004106
in subset: gosubset prok
type: Class
subclass of: GO_0016866

chorismate synthase activity
IAO_0000115: Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.
has db xref: EC:4.2.3.5
has db xref: KEGG:R01714
has db xref: MetaCyc:CHORISMATE-SYNTHASE-RXN
has db xref: RHEA:21023
has db xref: Reactome:REACT_27204
has exact synonym: 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)
has exact synonym: 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity
has exact synonym: 5-enolpyruvylshikimate-3-phosphate phospholyase activity
has OBO namespace: molecular_function
id: GO:0004107
in subset: gosubset prok
type: Class
subclass of: GO_0016838

citrate (Si)-synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
has broad synonym: citrate synthase activity
has broad synonym: condensing enzyme activity
has db xref: EC:2.3.3.1
has db xref: MetaCyc:CITSYN-RXN
has db xref: RHEA:16848
has db xref: Reactome:REACT_100557
has db xref: Reactome:REACT_100736
has db xref: Reactome:REACT_103631
has db xref: Reactome:REACT_107569
has db xref: Reactome:REACT_108814
has db xref: Reactome:REACT_115605
has db xref: Reactome:REACT_1282
has db xref: Reactome:REACT_32191
has db xref: Reactome:REACT_33399
has db xref: Reactome:REACT_81174
has db xref: Reactome:REACT_81802
has db xref: Reactome:REACT_83386
has db xref: Reactome:REACT_87177
has db xref: Reactome:REACT_88391
has db xref: Reactome:REACT_91540
has db xref: Reactome:REACT_94285
has db xref: Reactome:REACT_96879
has exact synonym: (R)-citric synthase activity
has exact synonym: citrate condensing enzyme activity
has exact synonym: citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
has exact synonym: citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
has exact synonym: citrate oxaloacetate-lyase, CoA-acetylating activity
has exact synonym: citrate synthetase activity
has exact synonym: citric synthase activity
has exact synonym: citric-condensing enzyme activity
has exact synonym: citrogenase activity
has exact synonym: oxalacetic transacetase activity
has exact synonym: oxaloacetate transacetase activity
has OBO namespace: molecular_function
has related synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
has related synonym: citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
id: GO:0004108
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.3.7.
subclass of: GO_0046912

coproporphyrinogen oxidase activity
IAO_0000115: Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.
has db xref: EC:1.3.3.3
has db xref: KEGG:R03220
has db xref: MetaCyc:RXN0-1461
has db xref: RHEA:18260
has db xref: Reactome:REACT_100303
has db xref: Reactome:REACT_102127
has db xref: Reactome:REACT_106413
has db xref: Reactome:REACT_109036
has db xref: Reactome:REACT_109488
has db xref: Reactome:REACT_116046
has db xref: Reactome:REACT_28640
has db xref: Reactome:REACT_31610
has db xref: Reactome:REACT_33035
has db xref: Reactome:REACT_33168
has db xref: Reactome:REACT_79367
has db xref: Reactome:REACT_82126
has db xref: Reactome:REACT_83357
has db xref: Reactome:REACT_90082
has db xref: Reactome:REACT_90208
has db xref: Reactome:REACT_91427
has db xref: Reactome:REACT_93659
has db xref: Reactome:REACT_9421
has db xref: Reactome:REACT_98194
has exact synonym: coprogen oxidase activity
has exact synonym: coproporphyrinogen-III oxidase activity
has exact synonym: coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
has exact synonym: coproporphyrinogenase activity
has OBO namespace: molecular_function
id: GO:0004109
in subset: gosubset prok
type: Class
subclass of: GO_0016634

corticosteroid side-chain-isomerase activity
IAO_0000115: Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al.
has db xref: EC:5.3.1.21
has db xref: KEGG:R04165
has db xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN
has db xref: RHEA:17864
has exact synonym: 11-deoxycorticosterone aldose-ketose-isomerase activity
has exact synonym: 11-deoxycorticosterone ketol-isomerase activity
has OBO namespace: molecular_function
id: GO:0004110
type: Class
subclass of: GO_0016861

creatine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
has db xref: EC:2.7.3.2
has db xref: KEGG:R01881
has db xref: MetaCyc:CREATINE-KINASE-RXN
has db xref: RHEA:17160
has db xref: Reactome:REACT_100539
has db xref: Reactome:REACT_101438
has db xref: Reactome:REACT_105411
has db xref: Reactome:REACT_108499
has db xref: Reactome:REACT_109981
has db xref: Reactome:REACT_110682
has db xref: Reactome:REACT_11155
has db xref: Reactome:REACT_11156
has db xref: Reactome:REACT_111938
has db xref: Reactome:REACT_112531
has db xref: Reactome:REACT_113875
has db xref: Reactome:REACT_31867
has db xref: Reactome:REACT_32596
has db xref: Reactome:REACT_34284
has db xref: Reactome:REACT_84876
has db xref: Reactome:REACT_87789
has db xref: Reactome:REACT_90123
has db xref: Reactome:REACT_94681
has db xref: Reactome:REACT_94782
has db xref: Reactome:REACT_96287
has db xref: Reactome:REACT_99155
has exact synonym: ATP:creatine N-phosphotransferase activity
has exact synonym: ATP:creatine phosphotransferase activity
has exact synonym: adenosine triphosphate-creatine transphosphorylase activity
has exact synonym: creatine phosphokinase activity
has exact synonym: creatine phosphotransferase activity
has exact synonym: phosphocreatine kinase activity
has OBO namespace: molecular_function
has related synonym: BB-CK
has related synonym: CK
has related synonym: CK-BB
has related synonym: CK-MB
has related synonym: CK-MM
has related synonym: CKMiMi
has related synonym: MB-CK
has related synonym: MM-CK
has related synonym: Mi-CK
has related synonym: MiMi-CK
id: GO:0004111
type: Class
subclass of: GO_0016301
subclass of: GO_0016775

cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
has db xref: EC:3.1.4.-
has OBO namespace: molecular_function
id: GO:0004112
in subset: gosubset prok
type: Class
subclass of: GO_0008081

2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
has broad synonym: 2',3'-cyclic nucleoside monophosphate phosphodiesterase
has broad synonym: 2',3'-cyclic nucleotide phosphohydrolase
has broad synonym: cyclic 2',3'-nucleotide phosphodiesterase
has db xref: EC:3.1.4.37
has db xref: MetaCyc:3.1.4.37-RXN
has exact synonym: 2',3'-cyclic AMP phosphodiesterase activity
has exact synonym: 2',3'-cyclic nucleotide 3'-phosphodiesterase activity
has exact synonym: 2',3'-cyclic nucleotide 3'-phosphohydrolase activity
has exact synonym: 2':3'-CNMP-3'-ase activity
has exact synonym: 2':3'-cyclic nucleotide 3'-phosphodiesterase activity
has exact synonym: CNPase activity
has exact synonym: cyclic 2',3'-nucleotide 3'-phosphodiesterase activity
has exact synonym: nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity
has narrow synonym: cyclic-CMP phosphodiesterase activity
has OBO namespace: molecular_function
id: GO:0004113
in subset: gosubset prok
type: Class
subclass of: cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
has db xref: EC:3.1.4.17
has db xref: MetaCyc:3.1.4.17-RXN
has db xref: RHEA:14656
has db xref: Reactome:REACT_105099
has db xref: Reactome:REACT_106371
has db xref: Reactome:REACT_109851
has db xref: Reactome:REACT_114232
has db xref: Reactome:REACT_28964
has db xref: Reactome:REACT_325
has db xref: Reactome:REACT_80740
has db xref: Reactome:REACT_82008
has db xref: Reactome:REACT_83917
has db xref: Reactome:REACT_91190
has db xref: Reactome:REACT_98934
has db xref: Reactome:REACT_99156
has exact synonym: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity
has exact synonym: 3',5' cyclic-nucleotide phosphodiesterase activity
has exact synonym: 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity
has exact synonym: 3',5'-cyclonucleotide phosphodiesterase activity
has exact synonym: 3',5'-nucleotide phosphodiesterase activity
has exact synonym: 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity
has exact synonym: 3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity
has exact synonym: cyclic 3',5'-mononucleotide phosphodiesterase activity
has exact synonym: cyclic 3',5'-nucleotide phosphodiesterase activity
has exact synonym: cyclic 3',5'-phosphodiesterase activity
has exact synonym: cyclic 3',5-nucleotide monophosphate phosphodiesterase activity
has exact synonym: cyclic nucleotide phosphodiesterase activity
has exact synonym: cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity
has exact synonym: nucleoside 3',5'-cyclic phosphate diesterase activity
has exact synonym: nucleoside-3',5-monophosphate phosphodiesterase activity
has narrow synonym: cyclic AMP phosphodiesterase activity
has OBO namespace: molecular_function
has related synonym: PDE
id: GO:0004114
in subset: gosubset prok
type: Class
subclass of: cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
has db xref: EC:3.1.4.-
has db xref: MetaCyc:RXN0-5038
has db xref: Reactome:REACT_103170
has db xref: Reactome:REACT_104009
has db xref: Reactome:REACT_109814
has db xref: Reactome:REACT_110463
has db xref: Reactome:REACT_112238
has db xref: Reactome:REACT_115186
has db xref: Reactome:REACT_1257
has db xref: Reactome:REACT_19387
has db xref: Reactome:REACT_30870
has db xref: Reactome:REACT_31083
has db xref: Reactome:REACT_31890
has db xref: Reactome:REACT_33515
has db xref: Reactome:REACT_33747
has db xref: Reactome:REACT_34147
has db xref: Reactome:REACT_34190
has db xref: Reactome:REACT_77308
has db xref: Reactome:REACT_82598
has db xref: Reactome:REACT_85939
has db xref: Reactome:REACT_86709
has db xref: Reactome:REACT_88948
has db xref: Reactome:REACT_89237
has db xref: Reactome:REACT_94229
has db xref: Reactome:REACT_96329
has db xref: Reactome:REACT_96372
has db xref: Reactome:REACT_98400
has db xref: Reactome:REACT_99458
has db xref: Reactome:REACT_99647
has db xref: Reactome:REACT_99851
has exact synonym: 3',5' cAMP-specific phosphodiesterase activity
has exact synonym: 3',5'-cAMP-specific phosphodiesterase activity
has exact synonym: 3',5'-cyclic-AMP-specific phosphodiesterase activity
has exact synonym: adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
has exact synonym: cAMP-specific phosphodiesterase activity
has exact synonym: cyclic AMP-specific phosphodiesterase activity
has OBO namespace: molecular_function
id: GO:0004115
in subset: gosubset prok
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
has db xref: EC:3.1.4.-
has db xref: Reactome:REACT_100660
has db xref: Reactome:REACT_102161
has db xref: Reactome:REACT_104978
has db xref: Reactome:REACT_105407
has db xref: Reactome:REACT_105998
has db xref: Reactome:REACT_114149
has db xref: Reactome:REACT_114485
has db xref: Reactome:REACT_28755
has db xref: Reactome:REACT_33765
has db xref: Reactome:REACT_82138
has db xref: Reactome:REACT_827
has db xref: Reactome:REACT_83188
has db xref: Reactome:REACT_83224
has db xref: Reactome:REACT_85278
has OBO namespace: molecular_function
id: GO:0004117
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
has db xref: EC:3.1.4.-
has OBO namespace: molecular_function
id: GO:0004118
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.
has db xref: EC:3.1.4.-
has OBO namespace: molecular_function
id: GO:0004119
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

photoreceptor cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide.
has db xref: EC:3.1.4.-
has OBO namespace: molecular_function
id: GO:0004120
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

cystathionine beta-lyase activity
IAO_0000115: Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate.
has alternative id: GO:0008799
has db xref: EC:4.4.1.8
has db xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN
has db xref: RHEA:13968
has exact synonym: L-cystathionine L-homocysteine-lyase (deaminating)
has exact synonym: L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)
has exact synonym: beta C-S lyase activity
has exact synonym: beta-cystathionase activity
has exact synonym: cystathionine L-homocysteine-lyase (deaminating)
has exact synonym: cystine lyase activity
has OBO namespace: molecular_function
id: GO:0004121
in subset: gosubset prok
type: Class
subclass of: GO_0016846

cystathionine beta-synthase activity
IAO_0000115: Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
has db xref: EC:4.2.1.22
has db xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
has db xref: RHEA:10115
has db xref: Reactome:REACT_115874
has exact synonym: L-serine hydro-lyase (adding homocysteine)
has exact synonym: L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
has exact synonym: beta-thionase activity
has exact synonym: methylcysteine synthase activity
has exact synonym: serine sulfhydrase activity
has exact synonym: serine sulfhydrylase activity
has OBO namespace: molecular_function
id: GO:0004122
in subset: gosubset prok
type: Class
subclass of: GO_0016836

cystathionine gamma-lyase activity
IAO_0000115: Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
has alternative id: GO:0016225
has broad synonym: L-cystathionine cysteine-lyase (deaminating)
has broad synonym: gamma-cystathionase activity
has db xref: EC:4.4.1.1
has db xref: KEGG:R01001
has db xref: MetaCyc:CYSTAGLY-RXN
has db xref: RHEA:24918
has db xref: Reactome:REACT_116098
has db xref: Reactome:REACT_27170
has exact synonym: L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
has OBO namespace: molecular_function
has related synonym: homoserine deaminase activity
has related synonym: homoserine deaminase-cystathionase activity
has related synonym: homoserine dehydratase activity
id: GO:0004123
type: Class
subclass of: GO_0016846

cysteine synthase activity
IAO_0000115: Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
has db xref: EC:2.5.1.47
has db xref: MetaCyc:ACSERLY-RXN
has db xref: RHEA:14832
has db xref: Reactome:REACT_27172
has db xref: Reactome:REACT_27282
has exact synonym: 3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
has exact synonym: O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity
has exact synonym: O-acetyl-L-serine sulfhydrylase activity
has exact synonym: O-acetyl-L-serine sulfohydrolase activity
has exact synonym: O-acetylserine (thiol)-lyase activity
has exact synonym: O-acetylserine sulfhydrylase activity
has exact synonym: O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)
has exact synonym: O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
has exact synonym: OAS sulfhydrylase activity
has exact synonym: acetylserine sulfhydrylase activity
has exact synonym: cysteine synthetase activity
has narrow synonym: O-acetylserine (thiol)-lyase A activity
has OBO namespace: molecular_function
id: GO:0004124
in subset: gosubset prok
type: Class
comment: Note that this function was formerly 4.2.99.8.
subclass of: GO_0016835

L-seryl-tRNASec selenium transferase activity
IAO_0000115: Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.
has db xref: EC:2.9.1.1
has db xref: MetaCyc:2.9.1.1-RXN
has exact synonym: L-selenocysteinyl-tRNA(Sec) synthase activity
has exact synonym: L-selenocysteinyl-tRNA(Sel) synthase activity
has exact synonym: L-selenocysteinyl-tRNASec synthase activity
has exact synonym: L-selenocysteinyl-tRNASel synthase activity
has exact synonym: L-seryl-tRNA(Ser) selenium transferase activity
has exact synonym: cysteinyl-tRNA(Sec)-selenium transferase activity
has exact synonym: cysteinyl-tRNA(Sel)-selenium transferase activity
has exact synonym: cysteinyl-tRNA(Ser) selenium transferase activity
has exact synonym: cysteinyl-tRNASec-selenium transferase activity
has exact synonym: cysteinyl-tRNASel-selenium transferase activity
has exact synonym: selenocysteine synthase activity
has exact synonym: selenocysteinyl-tRNA(Ser) synthase activity
has exact synonym: selenophosphate:L-seryl-tRNASec selenium transferase activity
has OBO namespace: molecular_function
id: GO:0004125
in subset: gosubset prok
type: Class
subclass of: GO_0016785

cytidine deaminase activity
IAO_0000115: Catalysis of the reaction: cytidine + H2O = uridine + NH3.
has db xref: EC:3.5.4.5
has db xref: MetaCyc:CYTIDEAM2-RXN
has db xref: RHEA:16072
has db xref: Reactome:REACT_100555
has db xref: Reactome:REACT_102821
has db xref: Reactome:REACT_103670
has db xref: Reactome:REACT_104831
has db xref: Reactome:REACT_105043
has db xref: Reactome:REACT_106971
has db xref: Reactome:REACT_107871
has db xref: Reactome:REACT_108941
has db xref: Reactome:REACT_30951
has db xref: Reactome:REACT_376
has db xref: Reactome:REACT_80189
has db xref: Reactome:REACT_81775
has db xref: Reactome:REACT_86483
has db xref: Reactome:REACT_86734
has db xref: Reactome:REACT_869
has db xref: Reactome:REACT_89154
has db xref: Reactome:REACT_91892
has db xref: Reactome:REACT_92525
has db xref: Reactome:REACT_92541
has db xref: Reactome:REACT_92713
has db xref: Reactome:REACT_94503
has db xref: Reactome:REACT_94636
has db xref: Reactome:REACT_94708
has exact synonym: cytidine aminohydrolase activity
has exact synonym: cytosine nucleoside deaminase activity
has OBO namespace: molecular_function
id: GO:0004126
in subset: gosubset prok
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

cytidylate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.
has broad synonym: deoxycytidylate kinase activity
has db xref: EC:2.7.4.14
has db xref: MetaCyc:CMPKI-RXN
has db xref: RHEA:11604
has db xref: RHEA:25097
has exact synonym: ATP:CMP phosphotransferase activity
has exact synonym: ATP:UMP-CMP phosphotransferase activity
has exact synonym: CTP:CMP phosphotransferase activity
has exact synonym: UMP-CMP kinase activity
has exact synonym: cytidine monophosphate kinase activity
has exact synonym: deoxycytidine monophosphokinase activity
has exact synonym: pyrimidine nucleoside monophosphate kinase activity
has narrow synonym: CMP kinase activity
has narrow synonym: dCMP kinase activity
has OBO namespace: molecular_function
id: GO:0004127
in subset: gosubset prok
type: Class
subclass of: GO_0019201

cytochrome-b5 reductase activity
IAO_0000115: Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
has db xref: EC:1.6.2.2
has db xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
has db xref: Reactome:REACT_103424
has db xref: Reactome:REACT_104486
has db xref: Reactome:REACT_11182
has db xref: Reactome:REACT_30308
has db xref: Reactome:REACT_78517
has db xref: Reactome:REACT_79858
has db xref: Reactome:REACT_85388
has db xref: Reactome:REACT_90736
has db xref: Reactome:REACT_90791
has db xref: Reactome:REACT_95419
has exact synonym: NADH 5alpha-reductase activity
has exact synonym: NADH-cytochrome b5 reductase activity
has exact synonym: NADH-cytochrome-b5 reductase activity
has exact synonym: NADH-ferricytochrome b5 oxidoreductase activity
has exact synonym: NADH:ferricytochrome-b5 oxidoreductase activity
has exact synonym: cytochrome b5 reductase activity
has exact synonym: dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
has exact synonym: reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity
has OBO namespace: molecular_function
id: GO:0004128
type: Class
subclass of: GO_0016653

cytochrome-c oxidase activity
IAO_0000115: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
has db xref: EC:1.9.3.1
has db xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN
has db xref: Reactome:REACT_113276
has db xref: Reactome:REACT_113311
has db xref: Reactome:REACT_113736
has db xref: Reactome:REACT_115027
has db xref: Reactome:REACT_33608
has db xref: Reactome:REACT_6149
has db xref: Reactome:REACT_78871
has db xref: Reactome:REACT_99789
has exact synonym: NADH cytochrome c oxidase
has narrow synonym: aa3-type cytochrome c oxidase
has narrow synonym: ba3-type cytochrome c oxidase
has narrow synonym: caa3-type cytochrome c oxidase
has narrow synonym: cbb3-type cytochrome c oxidase
has narrow synonym: cytochrome a3 activity
has narrow synonym: cytochrome aa3 activity
has narrow synonym: ferrocytochrome c oxidase
has narrow synonym: ferrocytochrome-c:oxygen oxidoreductase
has narrow synonym: indophenol oxidase
has narrow synonym: indophenolase
has OBO namespace: molecular_function
has related synonym: complex IV (mitochondrial electron transport) activity
has related synonym: cytochrome oxidase activity
has related synonym: warburg's respiratory enzyme activity
id: GO:0004129
in subset: gosubset prok
type: Class
comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
subclass of: GO_0015002
subclass of: GO_0015078
subclass of: GO_0016676

cytochrome-c peroxidase activity
IAO_0000115: Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O.
has db xref: EC:1.11.1.5
has db xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN
has exact synonym: apocytochrome c peroxidase activity
has exact synonym: cytochrome c peroxidase activity
has exact synonym: cytochrome c-551 peroxidase activity
has exact synonym: cytochrome c-H2O oxidoreductase activity
has exact synonym: cytochrome peroxidase activity
has exact synonym: ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: mesocytochrome c peroxidase azide
has related synonym: mesocytochrome c peroxidase cyanate
has related synonym: mesocytochrome c peroxidase cyanide
id: GO:0004130
in subset: gosubset prok
type: Class
subclass of: GO_0004601

cytosine deaminase activity
IAO_0000115: Catalysis of the reaction: cytosine + H2O = uracil + NH3.
has db xref: EC:3.5.4.1
has db xref: MetaCyc:CYTDEAM-RXN
has db xref: RHEA:20608
has exact synonym: cytosine aminohydrolase activity
has exact synonym: isocytosine deaminase activity
has OBO namespace: molecular_function
id: GO:0004131
in subset: gosubset prok
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

dCMP deaminase activity
IAO_0000115: Catalysis of the reaction: dCMP + H2O = dUMP + NH3.
has db xref: EC:3.5.4.12
has db xref: MetaCyc:DCMP-DEAMINASE-RXN
has db xref: RHEA:22927
has db xref: Reactome:REACT_101387
has db xref: Reactome:REACT_102792
has db xref: Reactome:REACT_105322
has db xref: Reactome:REACT_105695
has db xref: Reactome:REACT_106595
has db xref: Reactome:REACT_110788
has db xref: Reactome:REACT_30304
has db xref: Reactome:REACT_31119
has db xref: Reactome:REACT_33008
has db xref: Reactome:REACT_34269
has db xref: Reactome:REACT_81043
has db xref: Reactome:REACT_82206
has db xref: Reactome:REACT_84263
has db xref: Reactome:REACT_879
has db xref: Reactome:REACT_90963
has db xref: Reactome:REACT_95511
has db xref: Reactome:REACT_95855
has exact synonym: dCMP aminohydrolase activity
has exact synonym: deoxy-CMP-deaminase activity
has exact synonym: deoxycytidine monophosphate deaminase activity
has exact synonym: deoxycytidine-5'-monophosphate aminohydrolase activity
has exact synonym: deoxycytidine-5'-phosphate deaminase activity
has exact synonym: deoxycytidylate aminohydrolase activity
has exact synonym: deoxycytidylate deaminase activity
has OBO namespace: molecular_function
id: GO:0004132
in subset: gosubset prok
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

glycogen debranching enzyme activity
IAO_0000115: Catalysis of the cleavage of branch points in branched glycogen polymers.
has OBO namespace: molecular_function
id: GO:0004133
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: catalytic activity

4-alpha-glucanotransferase activity
IAO_0000115: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.
has db xref: EC:2.4.1.25
has db xref: MetaCyc:AMYLOMALT-RXN
has db xref: MetaCyc:RXN-1828
has db xref: MetaCyc:RXN-9023
has db xref: Reactome:REACT_102056
has db xref: Reactome:REACT_1507
has db xref: Reactome:REACT_29429
has db xref: Reactome:REACT_29453
has db xref: Reactome:REACT_31073
has db xref: Reactome:REACT_32827
has db xref: Reactome:REACT_34234
has db xref: Reactome:REACT_80055
has db xref: Reactome:REACT_82649
has db xref: Reactome:REACT_83752
has db xref: Reactome:REACT_88252
has db xref: Reactome:REACT_88797
has exact synonym: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity
has exact synonym: amylomaltase activity
has exact synonym: debranching enzyme maltodextrin glycosyltransferase activity
has exact synonym: dextrin transglycosylase activity
has exact synonym: oligo-1,4-1,4-glucantransferase activity
has OBO namespace: molecular_function
has related synonym: D-enzyme activity
has related synonym: dextrin glycosyltransferase activity
has related synonym: disproportionating enzyme activity
id: GO:0004134
in subset: gosubset prok
type: Class
subclass of: glycogen debranching enzyme activity
subclass of: GO_0016758

amylo-alpha-1,6-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.
has db xref: EC:3.2.1.33
has db xref: MetaCyc:3.2.1.33-RXN
has db xref: Reactome:REACT_106625
has db xref: Reactome:REACT_108579
has db xref: Reactome:REACT_108658
has db xref: Reactome:REACT_1433
has db xref: Reactome:REACT_79503
has db xref: Reactome:REACT_83785
has db xref: Reactome:REACT_84618
has db xref: Reactome:REACT_88815
has db xref: Reactome:REACT_90121
has db xref: Reactome:REACT_93342
has db xref: Reactome:REACT_95109
has db xref: Reactome:REACT_97615
has exact synonym: amylo-1,6-glucosidase activity
has exact synonym: amylopectin 1,6-glucosidase activity
has exact synonym: dextrin-1,6-glucosidase activity
has exact synonym: glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity
has OBO namespace: molecular_function
has related synonym: dextrin 6-alpha-D-glucosidase activity
id: GO:0004135
in subset: gosubset prok
type: Class
subclass of: glycogen debranching enzyme activity
subclass of: alpha-glucosidase activity

deoxyadenosine kinase activity
IAO_0000115: Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+).
has db xref: EC:2.7.1.76
has db xref: KEGG:R02089
has db xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN
has db xref: RHEA:23455
has exact synonym: ATP:deoxyadenosine 5'-phosphotransferase activity
has exact synonym: deoxyadenosine kinase (phosphorylating)
has exact synonym: purine-deoxyribonucleoside kinase activity
has OBO namespace: molecular_function
id: GO:0004136
in subset: gosubset prok
type: Class
subclass of: GO_0019136

deoxycytidine kinase activity
IAO_0000115: Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
has db xref: EC:2.7.1.74
has db xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN
has db xref: RHEA:20064
has exact synonym: 2'-deoxycytidine kinase activity
has exact synonym: Ara-C kinase activity
has exact synonym: NTP:deoxycytidine 5'-phosphotransferase activity
has exact synonym: arabinofuranosylcytosine kinase activity
has exact synonym: deoxycytidine kinase (phosphorylating)
has exact synonym: deoxycytidine-cytidine kinase activity
has OBO namespace: molecular_function
id: GO:0004137
in subset: gosubset prok
type: Class
subclass of: GO_0019136

deoxyguanosine kinase activity
IAO_0000115: Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
has db xref: EC:2.7.1.113
has db xref: KEGG:R01967
has db xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN
has db xref: RHEA:19204
has exact synonym: (dihydroxypropoxymethyl)guanine kinase activity
has exact synonym: 2'-deoxyguanosine kinase activity
has exact synonym: ATP:deoxyguanosine 5'-phosphotransferase activity
has exact synonym: NTP-deoxyguanosine 5'-phosphotransferase activity
has exact synonym: deoxyguanosine kinase (phosphorylating)
has OBO namespace: molecular_function
id: GO:0004138
in subset: gosubset prok
type: Class
subclass of: GO_0019136

deoxyribose-phosphate aldolase activity
IAO_0000115: Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
has db xref: EC:4.1.2.4
has db xref: KEGG:R01066
has db xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN
has db xref: RHEA:12824
has exact synonym: 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
has exact synonym: 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity
has exact synonym: 2-deoxyribose-5-phosphate aldolase activity
has exact synonym: deoxyribose-5-phosphate aldolase activity
has exact synonym: phosphodeoxyriboaldolase activity
has OBO namespace: molecular_function
has related synonym: deoxyriboaldolase activity
id: GO:0004139
in subset: gosubset prok
type: Class
subclass of: GO_0016832

dephospho-CoA kinase activity
IAO_0000115: Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+).
has db xref: EC:2.7.1.24
has db xref: KEGG:R00130
has db xref: MetaCyc:DEPHOSPHOCOAKIN-RXN
has db xref: RHEA:18248
has db xref: Reactome:REACT_102484
has db xref: Reactome:REACT_110357
has db xref: Reactome:REACT_11093
has db xref: Reactome:REACT_112662
has db xref: Reactome:REACT_30468
has db xref: Reactome:REACT_30902
has db xref: Reactome:REACT_32306
has db xref: Reactome:REACT_33500
has db xref: Reactome:REACT_82321
has db xref: Reactome:REACT_89804
has db xref: Reactome:REACT_90005
has db xref: Reactome:REACT_93983
has db xref: Reactome:REACT_99187
has exact synonym: 3'-dephospho-CoA kinase activity
has exact synonym: ATP:dephospho-CoA 3'-phosphotransferase activity
has exact synonym: dephosphocoenzyme A kinase (phosphorylating)
has OBO namespace: molecular_function
has related synonym: dephosphocoenzyme A kinase activity
id: GO:0004140
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

dethiobiotin synthase activity
IAO_0000115: Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate.
has db xref: EC:6.3.3.3
has db xref: KEGG:R03182
has db xref: MetaCyc:DETHIOBIOTIN-SYN-RXN
has db xref: RHEA:15808
has exact synonym: 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)
has exact synonym: DTB synthetase activity
has exact synonym: desthiobiotin synthase activity
has OBO namespace: molecular_function
id: GO:0004141
in subset: gosubset prok
type: Class
subclass of: GO_0016882

diacylglycerol cholinephosphotransferase activity
IAO_0000115: Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.
has db xref: EC:2.7.8.2
has db xref: MetaCyc:RXN-5781
has db xref: RHEA:10311
has exact synonym: 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity
has exact synonym: 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity
has exact synonym: 1-alkyl-2-acetylglycerol cholinephosphotransferase activity
has exact synonym: CDP-choline diglyceride phosphotransferase activity
has exact synonym: CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity
has exact synonym: alkylacylglycerol choline phosphotransferase activity
has exact synonym: alkylacylglycerol cholinephosphotransferase activity
has exact synonym: cytidine diphosphocholine glyceride transferase activity
has exact synonym: cytidine diphosphorylcholine diglyceride transferase activity
has exact synonym: diacylglycerol choline phosphotransferase activity
has exact synonym: phosphocholine diacylglyceroltransferase activity
has exact synonym: phosphorylcholine--glyceride transferase activity
has exact synonym: sn-1,2-diacylglycerol cholinephosphotransferase activity
has OBO namespace: molecular_function
has related synonym: CPT
has related synonym: cholinephosphotransferase activity
id: GO:0004142
type: Class
subclass of: GO_0017169

diacylglycerol kinase activity
IAO_0000115: Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
has db xref: EC:2.7.1.107
has db xref: MetaCyc:DIACYLGLYKIN-RXN
has db xref: RHEA:10275
has db xref: Reactome:REACT_100005
has db xref: Reactome:REACT_101911
has db xref: Reactome:REACT_107713
has db xref: Reactome:REACT_109578
has db xref: Reactome:REACT_109644
has db xref: Reactome:REACT_109845
has db xref: Reactome:REACT_19402
has db xref: Reactome:REACT_78206
has db xref: Reactome:REACT_79070
has db xref: Reactome:REACT_93530
has db xref: Reactome:REACT_95006
has db xref: Reactome:REACT_99113
has db xref: Reactome:REACT_99297
has db xref: Reactome:REACT_99856
has db xref: Reactome:REACT_99935
has exact synonym: 1,2-diacylglycerol kinase (phosphorylating)
has exact synonym: 1,2-diacylglycerol kinase activity
has exact synonym: DG kinase activity
has exact synonym: DGK activity
has exact synonym: arachidonoyl-specific diacylglycerol kinase activity
has exact synonym: diglyceride kinase activity
has exact synonym: sn-1,2-diacylglycerol kinase activity
has narrow synonym: ATP:1,2-diacylglycerol 3-phosphotransferase activity
has narrow synonym: ATP:diacylglycerol phosphotransferase activity
has narrow synonym: CTP:diacylglycerol kinase activity
has narrow synonym: diacylglycerol:ATP kinase activity
has OBO namespace: molecular_function
id: GO:0004143
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

diacylglycerol O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
has db xref: EC:2.3.1.20
has db xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
has db xref: RHEA:10871
has db xref: Reactome:REACT_100155
has db xref: Reactome:REACT_103886
has db xref: Reactome:REACT_104139
has db xref: Reactome:REACT_104875
has db xref: Reactome:REACT_110678
has db xref: Reactome:REACT_112540
has db xref: Reactome:REACT_112715
has db xref: Reactome:REACT_114635
has db xref: Reactome:REACT_22179
has db xref: Reactome:REACT_28123
has db xref: Reactome:REACT_28392
has db xref: Reactome:REACT_31769
has db xref: Reactome:REACT_32550
has db xref: Reactome:REACT_659
has db xref: Reactome:REACT_77149
has db xref: Reactome:REACT_77431
has db xref: Reactome:REACT_81790
has db xref: Reactome:REACT_88501
has db xref: Reactome:REACT_89294
has db xref: Reactome:REACT_89429
has db xref: Reactome:REACT_92156
has db xref: Reactome:REACT_92925
has db xref: Reactome:REACT_93842
has db xref: Reactome:REACT_95845
has db xref: Reactome:REACT_96341
has db xref: Reactome:REACT_98065
has db xref: Reactome:REACT_98763
has db xref: Reactome:REACT_99469
has db xref: Reactome:REACT_99733
has exact synonym: 1,2-diacylglycerol acyltransferase activity
has exact synonym: acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
has exact synonym: diacylglycerol acyltransferase activity
has exact synonym: diglyceride O-acyltransferase activity
has exact synonym: diglyceride acyltransferase activity
has exact synonym: palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
has OBO namespace: molecular_function
id: GO:0004144
in subset: gosubset prok
type: Class
subclass of: GO_0016411

diamine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
has db xref: EC:2.3.1.57
has db xref: MetaCyc:DIAMACTRANS-RXN
has db xref: RHEA:25184
has db xref: Reactome:REACT_102979
has db xref: Reactome:REACT_103903
has db xref: Reactome:REACT_106439
has db xref: Reactome:REACT_106602
has db xref: Reactome:REACT_108255
has db xref: Reactome:REACT_108956
has db xref: Reactome:REACT_14811
has db xref: Reactome:REACT_14817
has db xref: Reactome:REACT_29565
has db xref: Reactome:REACT_31206
has db xref: Reactome:REACT_31654
has db xref: Reactome:REACT_32986
has db xref: Reactome:REACT_33438
has db xref: Reactome:REACT_78089
has db xref: Reactome:REACT_79405
has db xref: Reactome:REACT_80061
has db xref: Reactome:REACT_81463
has db xref: Reactome:REACT_81666
has db xref: Reactome:REACT_82051
has db xref: Reactome:REACT_85748
has db xref: Reactome:REACT_85868
has db xref: Reactome:REACT_86359
has db xref: Reactome:REACT_86990
has db xref: Reactome:REACT_90627
has db xref: Reactome:REACT_91691
has db xref: Reactome:REACT_92415
has db xref: Reactome:REACT_92789
has db xref: Reactome:REACT_93269
has db xref: Reactome:REACT_95402
has db xref: Reactome:REACT_95517
has db xref: Reactome:REACT_96189
has db xref: Reactome:REACT_96567
has db xref: Reactome:REACT_97328
has db xref: Reactome:REACT_99684
has exact synonym: acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity
has exact synonym: diamine acetyltransferase activity
has exact synonym: spermidine N1-acetyltransferase activity
has exact synonym: spermidine/spermine N1-acetyltransferase activity
has narrow synonym: acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity
has narrow synonym: putrescine (diamine)-acetylating enzyme activity
has narrow synonym: putrescine N-acetyltransferase activity
has narrow synonym: putrescine acetylase activity
has narrow synonym: putrescine acetyltransferase activity
has narrow synonym: spermidine N(1)-acetyltransferase activity
has narrow synonym: spermidine acetyltransferase activity
has narrow synonym: spermine N(1)-acetyltransferase
has narrow synonym: spermine acetyltransferase
has OBO namespace: molecular_function
has related synonym: spermine N-acetyltransferase
id: GO:0004145
in subset: gosubset prok
type: Class
subclass of: GO_0008080

dihydrofolate reductase activity
IAO_0000115: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
has db xref: EC:1.5.1.3
has db xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN
has db xref: RHEA:15012
has db xref: Reactome:REACT_111041
has db xref: Reactome:REACT_115762
has exact synonym: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
has exact synonym: 7,8-dihydrofolate reductase activity
has exact synonym: NADPH-dihydrofolate reductase activity
has exact synonym: dihydrofolate reductase:thymidylate synthase activity
has exact synonym: dihydrofolate reduction
has exact synonym: dihydrofolic acid reductase activity
has exact synonym: dihydrofolic reductase activity
has exact synonym: folic acid reductase activity
has exact synonym: folic reductase activity
has exact synonym: pteridine reductase:dihydrofolate reductase activity
has exact synonym: tetrahydrofolate dehydrogenase activity
has exact synonym: thymidylate synthetase-dihydrofolate reductase activity
has OBO namespace: molecular_function
has related synonym: DHFR
id: GO:0004146
in subset: gosubset prok
type: Class
subclass of: GO_0016646

dihydrolipoamide branched chain acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain.
has db xref: EC:2.3.1.-
has exact synonym: dihydrolipoamide branched chain transacylase activity
has OBO namespace: molecular_function
id: GO:0004147
in subset: gosubset prok
type: Class
subclass of: GO_0030523

dihydrolipoyl dehydrogenase activity
IAO_0000115: Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
has db xref: EC:1.8.1.4
has db xref: MetaCyc:DIHYDLIPOXN-RXN
has db xref: RHEA:15048
has exact synonym: dehydrolipoate dehydrogenase activity
has exact synonym: diaphorase activity
has exact synonym: dihydrolipoamide dehydrogenase activity
has exact synonym: dihydrolipoamide:NAD+ oxidoreductase
has exact synonym: dihydrolipoic dehydrogenase activity
has exact synonym: dihydrothioctic dehydrogenase activity
has exact synonym: lipoamide dehydrogenase (NADH) activity
has exact synonym: lipoamide oxidoreductase (NADH) activity
has exact synonym: lipoamide reductase (NADH) activity
has exact synonym: lipoamide reductase activity
has exact synonym: lipoate dehydrogenase activity
has exact synonym: lipoic acid dehydrogenase activity
has exact synonym: lipoyl dehydrogenase activity
has exact synonym: protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
has exact synonym: protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
has narrow synonym: LDP-Glc activity
has narrow synonym: LDP-Val activity
has OBO namespace: molecular_function
has related synonym: E3 component of alpha-ketoacid dehydrogenase complexes activity
has related synonym: L-protein activity
has related synonym: dihydrolipoamide reduction
has related synonym: dihydrolipoylprotein reduction
has related synonym: glycine-cleavage system L-protein activity
id: GO:0004148
in subset: gosubset prok
type: Class
subclass of: GO_0016668

dihydrolipoyllysine-residue succinyltransferase activity
IAO_0000115: Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
has db xref: EC:2.3.1.61
has exact synonym: dihydrolipoamide S-succinyltransferase activity
has exact synonym: dihydrolipoamide succinyltransferase activity
has exact synonym: dihydrolipoic transsuccinylase activity
has exact synonym: dihydrolipolyl transsuccinylase activity
has exact synonym: dihydrolipoyl transsuccinylase activity
has exact synonym: enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
has exact synonym: lipoate succinyltransferase (Escherichia coli) activity
has exact synonym: lipoate succinyltransferase activity
has exact synonym: lipoic transsuccinylase activity
has exact synonym: lipoyl transsuccinylase activity
has exact synonym: succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
has exact synonym: succinyl-CoA:dihydrolipoate S-succinyltransferase activity
has exact synonym: succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
has exact synonym: succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity
has OBO namespace: molecular_function
id: GO:0004149
in subset: gosubset prok
type: Class
subclass of: GO_0016751

dihydroneopterin aldolase activity
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
has db xref: EC:4.1.2.25
has db xref: MetaCyc:H2NEOPTERINALDOL-RXN
has db xref: RHEA:10543
has exact synonym: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)
has exact synonym: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity
has OBO namespace: molecular_function
id: GO:0004150
in subset: gosubset prok
type: Class
subclass of: GO_0016832

dihydroorotase activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+).
has db xref: EC:3.5.2.3
has db xref: KEGG:R01993
has db xref: MetaCyc:DIHYDROOROT-RXN
has db xref: RHEA:24299
has db xref: Reactome:REACT_100968
has db xref: Reactome:REACT_103707
has db xref: Reactome:REACT_104176
has db xref: Reactome:REACT_107004
has db xref: Reactome:REACT_109520
has db xref: Reactome:REACT_115876
has db xref: Reactome:REACT_30522
has db xref: Reactome:REACT_32485
has db xref: Reactome:REACT_32516
has db xref: Reactome:REACT_33026
has db xref: Reactome:REACT_744
has db xref: Reactome:REACT_78664
has db xref: Reactome:REACT_80045
has db xref: Reactome:REACT_89075
has db xref: Reactome:REACT_99796
has exact synonym: (S)-dihydroorotate amidohydrolase activity
has exact synonym: DHOase activity
has exact synonym: carbamoylaspartic dehydrase activity
has exact synonym: dihydroorotate hydrolase activity
has OBO namespace: molecular_function
id: GO:0004151
in subset: gosubset prok
type: Class
subclass of: GO_0016812

dihydroorotate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
has db xref: EC:1.3.5.2
has db xref: KEGG:R01868
has db xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN
has db xref: RHEA:18076
has db xref: Reactome:REACT_100074
has db xref: Reactome:REACT_101561
has db xref: Reactome:REACT_104099
has db xref: Reactome:REACT_105823
has db xref: Reactome:REACT_106035
has db xref: Reactome:REACT_109840
has db xref: Reactome:REACT_116075
has db xref: Reactome:REACT_32121
has db xref: Reactome:REACT_32336
has db xref: Reactome:REACT_32754
has db xref: Reactome:REACT_34767
has db xref: Reactome:REACT_669
has db xref: Reactome:REACT_77905
has db xref: Reactome:REACT_79091
has db xref: Reactome:REACT_82404
has db xref: Reactome:REACT_87685
has db xref: Reactome:REACT_89913
has db xref: Reactome:REACT_90116
has db xref: Reactome:REACT_96217
has db xref: Reactome:REACT_98035
has db xref: Reactome:REACT_99640
has exact synonym: (S)-dihydroorotate:quinone oxidoreductase activity
has exact synonym: DHOdehase activity
has exact synonym: dihydoorotic acid dehydrogenase activity
has narrow synonym: dihydroorotate:ubiquinone oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: (DHO) dehydrogenase activity
id: GO:0004152
in subset: gosubset prok
type: Class
subclass of: GO_0016635

dihydropterin deaminase activity
IAO_0000115: Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.
has OBO namespace: molecular_function
id: GO:0004153
type: Class
subclass of: GO_0019239

dihydropterin oxidase activity
IAO_0000115: Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide.
has db xref: EC:1.5.3.-
has OBO namespace: molecular_function
id: GO:0004154
type: Class
subclass of: GO_0016491

6,7-dihydropteridine reductase activity
IAO_0000115: Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.
has db xref: EC:1.5.1.34
has db xref: MetaCyc:1.5.1.34-RXN
has db xref: Reactome:REACT_101242
has db xref: Reactome:REACT_101276
has db xref: Reactome:REACT_1925
has db xref: Reactome:REACT_29183
has db xref: Reactome:REACT_30563
has db xref: Reactome:REACT_33125
has db xref: Reactome:REACT_33238
has db xref: Reactome:REACT_87568
has db xref: Reactome:REACT_92488
has db xref: Reactome:REACT_92901
has db xref: Reactome:REACT_93858
has db xref: Reactome:REACT_94721
has exact synonym: 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity
has exact synonym: 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity
has exact synonym: 6,7-dihydropteridine:NAD(P)H oxidoreductase activity
has exact synonym: DHPR activity
has exact synonym: NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity
has exact synonym: NAD(P)H2:6,7-dihydropteridine oxidoreductase activity
has exact synonym: NADH-dihydropteridine reductase activity
has exact synonym: NADPH-dihydropteridine reductase activity
has exact synonym: NADPH-specific dihydropteridine reductase activity
has exact synonym: dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity
has exact synonym: dihydropteridine reductase (NADH) activity
has exact synonym: dihydropteridine reductase activity
has OBO namespace: molecular_function
has related synonym: dihydropteridine reduction
id: GO:0004155
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:1.6.99.7.
subclass of: GO_0016646

dihydropteroate synthase activity
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
has db xref: EC:2.5.1.15
has db xref: MetaCyc:H2PTEROATESYNTH-RXN
has db xref: RHEA:19952
has exact synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
has exact synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
has exact synonym: 7,8-dihydropteroate synthase activity
has exact synonym: 7,8-dihydropteroate synthetase activity
has exact synonym: 7,8-dihydropteroic acid synthetase activity
has exact synonym: DHPS activity
has exact synonym: dihydropteroate diphosphorylase activity
has exact synonym: dihydropteroate pyrophosphorylase activity
has exact synonym: dihydropteroate synthetase activity
has exact synonym: dihydropteroic synthetase activity
has OBO namespace: molecular_function
id: GO:0004156
in subset: gosubset prok
type: Class
subclass of: GO_0016765

dihydropyrimidinase activity
IAO_0000115: Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.
has db xref: EC:3.5.2.2
has db xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN
has db xref: RHEA:16124
has db xref: Reactome:REACT_100830
has db xref: Reactome:REACT_101446
has db xref: Reactome:REACT_102809
has db xref: Reactome:REACT_103556
has db xref: Reactome:REACT_105429
has db xref: Reactome:REACT_107309
has db xref: Reactome:REACT_107362
has db xref: Reactome:REACT_108290
has db xref: Reactome:REACT_109169
has db xref: Reactome:REACT_113000
has db xref: Reactome:REACT_113669
has db xref: Reactome:REACT_1977
has db xref: Reactome:REACT_2169
has db xref: Reactome:REACT_29706
has db xref: Reactome:REACT_31178
has db xref: Reactome:REACT_31256
has db xref: Reactome:REACT_56207
has db xref: Reactome:REACT_81062
has db xref: Reactome:REACT_82327
has db xref: Reactome:REACT_82436
has db xref: Reactome:REACT_85710
has db xref: Reactome:REACT_87087
has db xref: Reactome:REACT_87711
has db xref: Reactome:REACT_89192
has db xref: Reactome:REACT_89935
has db xref: Reactome:REACT_90336
has db xref: Reactome:REACT_95295
has db xref: Reactome:REACT_95705
has db xref: Reactome:REACT_98259
has db xref: Reactome:REACT_99864
has exact synonym: 5,6-dihydropyrimidine amidohydrolase activity
has exact synonym: D-hydantoinase activity
has exact synonym: hydantoin peptidase activity
has exact synonym: hydantoinase activity
has exact synonym: hydropyrimidine hydrase activity
has exact synonym: pyrimidine hydrase activity
has OBO namespace: molecular_function
id: GO:0004157
in subset: gosubset prok
type: Class
subclass of: GO_0016812

dihydroorotate oxidase activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate.
has db xref: EC:1.3.3.1
has db xref: RHEA:15444
has exact synonym: (S)-dihydroorotate:oxygen oxidoreductase activity
has exact synonym: 4,5-L-dihydroorotate:oxygen oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004158
in subset: mf needs review
type: Class
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subclass of: dihydroorotate dehydrogenase activity
subclass of: GO_0016634

dihydrouracil dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+.
has db xref: EC:1.3.1.1
has db xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN
has db xref: RHEA:20192
has exact synonym: 5,6-dihydrouracil:NAD+ oxidoreductase activity
has exact synonym: dehydrogenase, dihydrouracil
has exact synonym: pyrimidine reductase activity
has exact synonym: thymine reductase activity
has exact synonym: uracil reductase activity
has OBO namespace: molecular_function
id: GO:0004159
type: Class
subclass of: GO_0016628

dihydroxy-acid dehydratase activity
IAO_0000115: Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
has db xref: EC:4.2.1.9
has db xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN
has db xref: RHEA:20939
has exact synonym: 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
has exact synonym: 2,3-dihydroxy-acid hydro-lyase activity
has exact synonym: 2,3-dihydroxyisovalerate dehydratase activity
has exact synonym: acetohydroxyacid dehydratase activity
has exact synonym: alpha,beta-dihydroxyacid dehydratase activity
has exact synonym: alpha,beta-dihydroxyisovalerate dehydratase activity
has exact synonym: dihydroxy acid dehydrase activity
has OBO namespace: molecular_function
has related synonym: DHAD
id: GO:0004160
in subset: gosubset prok
type: Class
subclass of: GO_0016836

dimethylallyltranstransferase activity
IAO_0000115: Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
has db xref: EC:2.5.1.1
has db xref: MetaCyc:GPPSYN-RXN
has db xref: RHEA:22411
has db xref: Reactome:REACT_100741
has db xref: Reactome:REACT_102050
has db xref: Reactome:REACT_102118
has db xref: Reactome:REACT_102935
has db xref: Reactome:REACT_103677
has db xref: Reactome:REACT_104071
has db xref: Reactome:REACT_107473
has db xref: Reactome:REACT_108928
has db xref: Reactome:REACT_109017
has db xref: Reactome:REACT_34263
has db xref: Reactome:REACT_34609
has db xref: Reactome:REACT_79289
has db xref: Reactome:REACT_87054
has db xref: Reactome:REACT_88460
has db xref: Reactome:REACT_89249
has db xref: Reactome:REACT_9467
has db xref: Reactome:REACT_96140
has db xref: Reactome:REACT_99636
has exact synonym: (2E,6E)-farnesyl diphosphate synthetase activity
has exact synonym: DMAPP:IPP-dimethylallyltransferase activity
has exact synonym: dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity
has exact synonym: dimethylallyltransferase activity
has exact synonym: diprenyltransferase activity
has exact synonym: geranyl pyrophosphate synthase activity
has exact synonym: geranyl pyrophosphate synthetase activity
has exact synonym: trans-farnesyl pyrophosphate synthetase activity
has OBO namespace: molecular_function
has related synonym: geranyl-diphosphate synthase activity
id: GO:0004161
in subset: gosubset prok
type: Class
comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
subclass of: GO_0004659

dimethylnitrosamine demethylase activity
IAO_0000115: Catalysis of the removal of a methyl group from N-nitrosodimethylamine.
has exact synonym: N-nitrosodimethylamine demethylase activity
has OBO namespace: molecular_function
id: GO:0004162
type: Class
subclass of: GO_0032451

diphosphomevalonate decarboxylase activity
IAO_0000115: Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.
has db xref: EC:4.1.1.33
has db xref: KEGG:R01121
has db xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN
has db xref: RHEA:23735
has db xref: Reactome:REACT_100521
has db xref: Reactome:REACT_101376
has db xref: Reactome:REACT_102913
has db xref: Reactome:REACT_104999
has db xref: Reactome:REACT_105125
has db xref: Reactome:REACT_108444
has db xref: Reactome:REACT_109965
has db xref: Reactome:REACT_28129
has db xref: Reactome:REACT_33654
has db xref: Reactome:REACT_78028
has db xref: Reactome:REACT_80726
has db xref: Reactome:REACT_81266
has db xref: Reactome:REACT_81926
has db xref: Reactome:REACT_81997
has db xref: Reactome:REACT_92755
has db xref: Reactome:REACT_9488
has db xref: Reactome:REACT_95775
has exact synonym: 5-pyrophosphomevalonate decarboxylase activity
has exact synonym: ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
has exact synonym: ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)
has exact synonym: mevalonate 5-diphosphate decarboxylase activity
has exact synonym: mevalonate diphosphate decarboxylase activity
has exact synonym: mevalonate pyrophosphate decarboxylase activity
has exact synonym: mevalonate-5-pyrophosphate decarboxylase activity
has exact synonym: pyrophosphomevalonate decarboxylase activity
has exact synonym: pyrophosphomevalonic acid decarboxylase activity
has OBO namespace: molecular_function
id: GO:0004163
in subset: gosubset prok
type: Class
subclass of: GO_0016831

diphthine synthase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.
has db xref: EC:2.1.1.98
has db xref: MetaCyc:RXN-11370
has db xref: RHEA:20148
has exact synonym: S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity
has exact synonym: diphthine methyltransferase activity
has OBO namespace: molecular_function
id: GO:0004164
in subset: gosubset prok
type: Class
subclass of: GO_0008757

dodecenoyl-CoA delta-isomerase activity
IAO_0000115: Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA.
has alternative id: GO:0008461
has broad synonym: delta3-cis-delta2-trans-enoyl-CoA isomerase
has db xref: EC:5.3.3.8
has db xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN
has db xref: RHEA:23719
has db xref: Reactome:REACT_104001
has db xref: Reactome:REACT_28905
has db xref: Reactome:REACT_588
has db xref: Reactome:REACT_78170
has db xref: Reactome:REACT_87434
has db xref: Reactome:REACT_88442
has db xref: Reactome:REACT_88978
has db xref: Reactome:REACT_95247
has db xref: Reactome:REACT_95915
has db xref: Reactome:REACT_96247
has db xref: Reactome:REACT_98886
has exact synonym: 3,2-trans-enoyl-CoA isomerase activity
has exact synonym: acetylene-allene isomerase activity
has exact synonym: delta(3),Delta(2)-enoyl-CoA isomerase activity
has exact synonym: delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity
has exact synonym: delta3,Delta2-enoyl-CoA isomerase activity
has exact synonym: dodecenoyl-CoA (3Z)-(2E)-isomerase activity
has exact synonym: dodecenoyl-CoA D-isomerase activity
has exact synonym: dodecenoyl-CoA Delta-isomerase activity
has exact synonym: dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity
has exact synonym: dodecenoyl-CoA isomerase activity
has OBO namespace: molecular_function
id: GO:0004165
in subset: gosubset prok
type: Class
subclass of: GO_0016863

dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.
has alternative id: GO:0004101
has db xref: EC:2.4.1.153
has db xref: MetaCyc:2.4.1.153-RXN
has db xref: RHEA:14696
has exact synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity
has exact synonym: dolichyl phosphate N-acetylglucosaminyltransferase activity
has exact synonym: dolichyl phosphate acetylglucosaminyltransferase activity
has exact synonym: dolichyl-phosphate N-acetylglucosaminyltransferase activity
has exact synonym: dolichyl-phosphate acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity
has OBO namespace: molecular_function
id: GO:0004166
type: Class
subclass of: GO_0008375

dopachrome isomerase activity
IAO_0000115: Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
has alternative id: GO:0048059
has broad synonym: dopachrome conversion activity
has broad synonym: dopachrome conversion factor activity
has db xref: EC:5.3.3.12
has db xref: KEGG:R03673
has db xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN
has db xref: RHEA:13044
has exact synonym: DCF activity
has exact synonym: DCT activity
has exact synonym: L-dopachrome isomerase activity
has exact synonym: L-dopachrome keto-enol isomerase activity
has exact synonym: L-dopachrome-methyl ester tautomerase activity
has exact synonym: TRP activity
has exact synonym: dopachrome Delta(7),Delta(2)-isomerase activity
has exact synonym: dopachrome delta-isomerase activity
has exact synonym: dopachrome delta7,Delta2-isomerase activity
has exact synonym: dopachrome keto-enol isomerase activity
has exact synonym: dopachrome oxidoreductase activity
has exact synonym: dopachrome rearranging enzyme activity
has exact synonym: dopachrome tautomerase activity
has exact synonym: tyrosinase-related protein 2 activity
has OBO namespace: molecular_function
has related synonym: TRP-1
has related synonym: TRP-2
has related synonym: TRP2
has related synonym: dopachrome-rearranging enzyme
has related synonym: tryosinase-related protein-2
id: GO:0004167
type: Class
subclass of: GO_0016863

dolichol kinase activity
IAO_0000115: Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.
has db xref: EC:2.7.1.108
has db xref: MetaCyc:DOLICHOL-KINASE-RXN
has db xref: RHEA:13136
has db xref: Reactome:REACT_22276
has exact synonym: CTP:dolichol O-phosphotransferase activity
has exact synonym: dolichol phosphokinase activity
has OBO namespace: molecular_function
id: GO:0004168
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

dolichyl-phosphate-mannose-protein mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.
has broad synonym: O-glycoside mannosyltransferase
has db xref: EC:2.4.1.109
has db xref: MetaCyc:2.4.1.109-RXN
has exact synonym: dolichol phosphomannose-protein mannosyltransferase activity
has exact synonym: dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity
has exact synonym: dolichyl-phosphate-mannose-protein O-mannosyltransferase activity
has exact synonym: protein O-D-mannosyltransferase activity
has exact synonym: protein O-mannosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004169
in subset: gosubset prok
type: Class
subclass of: mannosyltransferase activity

dUTP diphosphatase activity
IAO_0000115: Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate.
has db xref: EC:3.6.1.23
has db xref: KEGG:R02100
has db xref: MetaCyc:DUTP-PYROP-RXN
has db xref: RHEA:10251
has db xref: Reactome:REACT_103311
has db xref: Reactome:REACT_106534
has db xref: Reactome:REACT_108277
has db xref: Reactome:REACT_108948
has db xref: Reactome:REACT_109343
has db xref: Reactome:REACT_150
has db xref: Reactome:REACT_30531
has db xref: Reactome:REACT_54215
has db xref: Reactome:REACT_76954
has db xref: Reactome:REACT_77124
has db xref: Reactome:REACT_81301
has db xref: Reactome:REACT_82609
has db xref: Reactome:REACT_87407
has db xref: Reactome:REACT_92173
has db xref: Reactome:REACT_92619
has db xref: Reactome:REACT_96660
has db xref: Reactome:REACT_96711
has db xref: Reactome:REACT_97265
has exact synonym: dUTP nucleotidohydrolase activity
has exact synonym: dUTP pyrophosphatase activity
has exact synonym: dUTPase activity
has exact synonym: deoxyuridine-triphosphatase activity
has exact synonym: desoxyuridine 5'-triphosphatase activity
has exact synonym: desoxyuridine 5'-triphosphate nucleotidohydrolase activity
has OBO namespace: molecular_function
id: GO:0004170
in subset: gosubset prok
type: Class
subclass of: GO_0047429

deoxyhypusine synthase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
IAO_0100001: GO:0008612
IAO_0100001: GO:0034038
IAO_0100001: GO:0050983
has OBO namespace: molecular_function
has related synonym: [eIF-5A]-deoxyhypusine synthase
id: GO:0004171
type: Class
comment: This term was made obsolete because it represents a multistep reaction.
deprecated: true

ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0050488
has OBO namespace: molecular_function
id: GO:0004172
type: Class
comment: This term was made obsolete because it represents two molecular functions.
deprecated: true

ecdysone O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate.
has db xref: EC:2.3.1.139
has db xref: KEGG:R02375
has db xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN
has db xref: RHEA:15220
has exact synonym: acyl-CoA:ecdysone acyltransferase activity
has exact synonym: fatty acyl-CoA:ecdysone acyltransferase activity
has exact synonym: palmitoyl-CoA:ecdysone palmitoyltransferase activity
has OBO namespace: molecular_function
id: GO:0004173
type: Class
subclass of: GO_0008374

electron-transferring-flavoprotein dehydrogenase activity
IAO_0000115: Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol.
has db xref: EC:1.5.5.1
has db xref: MetaCyc:1.5.5.1-RXN
has db xref: Reactome:REACT_101766
has db xref: Reactome:REACT_108322
has db xref: Reactome:REACT_108711
has db xref: Reactome:REACT_32375
has db xref: Reactome:REACT_32665
has db xref: Reactome:REACT_32923
has db xref: Reactome:REACT_34198
has db xref: Reactome:REACT_6169
has db xref: Reactome:REACT_82024
has db xref: Reactome:REACT_82357
has db xref: Reactome:REACT_84406
has db xref: Reactome:REACT_84920
has db xref: Reactome:REACT_85394
has db xref: Reactome:REACT_88723
has db xref: Reactome:REACT_88890
has db xref: Reactome:REACT_95350
has db xref: Reactome:REACT_98526
has exact synonym: ETF dehydrogenase activity
has exact synonym: ETF-QO activity
has exact synonym: ETF-ubiquinone oxidoreductase activity
has exact synonym: ETF:ubiquinone oxidoreductase activity
has exact synonym: electron transfer flavoprotein Q oxidoreductase activity
has exact synonym: electron transfer flavoprotein dehydrogenase activity
has exact synonym: electron transfer flavoprotein reductase activity
has exact synonym: electron transfer flavoprotein-ubiquinone oxidoreductase activity
has exact synonym: electron-transferring-flavoprotein:ubiquinone oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004174
in subset: gosubset prok
type: Class
subclass of: GO_0016649

endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
has alternative id: GO:0016809
has broad synonym: proteinase
has db xref: Reactome:REACT_10017
has db xref: Reactome:REACT_101348
has db xref: Reactome:REACT_101866
has db xref: Reactome:REACT_101873
has db xref: Reactome:REACT_102952
has db xref: Reactome:REACT_103814
has db xref: Reactome:REACT_104331
has db xref: Reactome:REACT_104435
has db xref: Reactome:REACT_104684
has db xref: Reactome:REACT_104793
has db xref: Reactome:REACT_105135
has db xref: Reactome:REACT_105245
has db xref: Reactome:REACT_105748
has db xref: Reactome:REACT_106234
has db xref: Reactome:REACT_106385
has db xref: Reactome:REACT_106617
has db xref: Reactome:REACT_106687
has db xref: Reactome:REACT_107139
has db xref: Reactome:REACT_107146
has db xref: Reactome:REACT_108185
has db xref: Reactome:REACT_108448
has db xref: Reactome:REACT_108642
has db xref: Reactome:REACT_109047
has db xref: Reactome:REACT_109186
has db xref: Reactome:REACT_109261
has db xref: Reactome:REACT_110165
has db xref: Reactome:REACT_110191
has db xref: Reactome:REACT_110448
has db xref: Reactome:REACT_110469
has db xref: Reactome:REACT_110487
has db xref: Reactome:REACT_110752
has db xref: Reactome:REACT_111098
has db xref: Reactome:REACT_111104
has db xref: Reactome:REACT_111172
has db xref: Reactome:REACT_112076
has db xref: Reactome:REACT_113623
has db xref: Reactome:REACT_113749
has db xref: Reactome:REACT_114002
has db xref: Reactome:REACT_114449
has db xref: Reactome:REACT_114993
has db xref: Reactome:REACT_115363
has db xref: Reactome:REACT_115913
has db xref: Reactome:REACT_1210
has db xref: Reactome:REACT_13413
has db xref: Reactome:REACT_13491
has db xref: Reactome:REACT_13505
has db xref: Reactome:REACT_1355
has db xref: Reactome:REACT_13609
has db xref: Reactome:REACT_1471
has db xref: Reactome:REACT_15476
has db xref: Reactome:REACT_1673
has db xref: Reactome:REACT_20637
has db xref: Reactome:REACT_2142
has db xref: Reactome:REACT_25343
has db xref: Reactome:REACT_28448
has db xref: Reactome:REACT_28452
has db xref: Reactome:REACT_28694
has db xref: Reactome:REACT_29497
has db xref: Reactome:REACT_29888
has db xref: Reactome:REACT_30554
has db xref: Reactome:REACT_31644
has db xref: Reactome:REACT_32286
has db xref: Reactome:REACT_32345
has db xref: Reactome:REACT_32454
has db xref: Reactome:REACT_33103
has db xref: Reactome:REACT_33361
has db xref: Reactome:REACT_33702
has db xref: Reactome:REACT_34207
has db xref: Reactome:REACT_34441
has db xref: Reactome:REACT_38775
has db xref: Reactome:REACT_480
has db xref: Reactome:REACT_6715
has db xref: Reactome:REACT_6777
has db xref: Reactome:REACT_6826
has db xref: Reactome:REACT_6878
has db xref: Reactome:REACT_6937
has db xref: Reactome:REACT_75798

ATP-dependent peptidase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.
has alternative id: GO:0004280
has OBO namespace: molecular_function
has related synonym: ATP-dependent proteolysis
id: GO:0004176
in subset: gosubset prok
type: Class
subclass of: GO_0042623
subclass of: GO_0070011

aminopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
has db xref: EC:3.4.11
has db xref: Reactome:REACT_111222
has db xref: Reactome:REACT_75931
has OBO namespace: molecular_function
id: GO:0004177
in subset: gosubset prok
type: Class
subclass of: GO_0008238

leucyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.
IAO_0100001: GO:0004177
IAO_0100001: GO:0008235
has db xref: EC:3.4.11.1
has db xref: MetaCyc:3.4.11.1-RXN
has exact synonym: L-leucine aminopeptidase activity
has exact synonym: leucinamide aminopeptidase activity
has exact synonym: leucinaminopeptidase activity
has exact synonym: leucine aminopeptidase activity
has exact synonym: leucyl peptidase activity
has narrow synonym: cytosol aminopeptidase activity
has narrow synonym: peptidase S activity
has OBO namespace: molecular_function
has related synonym: FTBL proteins
has related synonym: aminopeptidase II
has related synonym: cathepsin III
has related synonym: proteinates FTBL
id: GO:0004178
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

membrane alanyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
IAO_0100001: GO:0004177
IAO_0100001: GO:0008235
has broad synonym: peptidase E activity
has db xref: EC:3.4.11.2
has db xref: MetaCyc:3.4.11.2-RXN
has exact synonym: L-alanine aminopeptidase activity
has exact synonym: alanine-specific aminopeptidase activity
has exact synonym: alanyl aminopeptidase activity
has exact synonym: amino-oligopeptidase activity
has exact synonym: cysteinylglycinase activity
has exact synonym: cysteinylglycine dipeptidase activity
has exact synonym: pseudo leucine aminopeptidase activity
has narrow synonym: aminopeptidase M activity
has narrow synonym: aminopeptidase N activity
has narrow synonym: membrane alanine aminopeptidase activity
has narrow synonym: membrane aminopeptidase I activity
has narrow synonym: microsomal aminopeptidase activity
has narrow synonym: particle-bound aminopeptidase activity
has OBO namespace: molecular_function
has related synonym: CD13
id: GO:0004179
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

carboxypeptidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
has db xref: Reactome:REACT_75845
has OBO namespace: molecular_function
id: GO:0004180
in subset: gosubset prok
type: Class
subclass of: GO_0008238

metallocarboxypeptidase activity
IAO_0000115: Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
has db xref: EC:3.4.17
has db xref: Reactome:REACT_103434
has db xref: Reactome:REACT_104808
has db xref: Reactome:REACT_15374
has db xref: Reactome:REACT_30489
has db xref: Reactome:REACT_31280
has db xref: Reactome:REACT_34275
has db xref: Reactome:REACT_76942
has db xref: Reactome:REACT_85582
has db xref: Reactome:REACT_93274
has OBO namespace: molecular_function
id: GO:0004181
in subset: gosubset prok
type: Class
subclass of: carboxypeptidase activity
subclass of: GO_0008235

carboxypeptidase A activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
IAO_0100001: GO:0004181
has alternative id: GO:0008731
has db xref: EC:3.4.17.1
has db xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN
has exact synonym: carboxypolypeptidase activity
has OBO namespace: molecular_function
has related synonym: pancreatic carboxypeptidase A
has related synonym: tissue carboxypeptidase A
id: GO:0004182
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

carboxypeptidase E activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.
IAO_0100001: GO:0004181
has broad synonym: peptidyl-L-lysine(-L-arginine) hydrolase
has db xref: EC:3.4.17.10
has db xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN
has exact synonym: carboxypeptidase H activity
has exact synonym: cobalt-stimulated chromaffin granule carboxypeptidase activity
has exact synonym: enkephalin precursor carboxypeptidase activity
has exact synonym: enkephalin-precursor endopeptidase activity
has exact synonym: insulin granule-associated carboxypeptidase activity
has exact synonym: membrane-bound carboxypeptidase activity
has narrow synonym: enkephalin convertase activity
has OBO namespace: molecular_function
id: GO:0004183
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

lysine carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
IAO_0100001: GO:0004181
has broad synonym: peptidyl-L-lysine(-L-arginine) hydrolase
has db xref: EC:3.4.17.3
has db xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN
has exact synonym: arginine carboxypeptidase activity
has exact synonym: bradykinase activity
has exact synonym: carboxypeptidase N activity
has exact synonym: creatinine kinase convertase activity
has exact synonym: hippuryllysine hydrolase activity
has exact synonym: kininase I activity
has exact synonym: lysine (arginine) carboxypeptidase activity
has exact synonym: lysine(arginine) carboxypeptidase activity
has narrow synonym: anaphylatoxin inactivator activity
has OBO namespace: molecular_function
has related synonym: CPase N
has related synonym: bradykinin-decomposing enzyme
has related synonym: creatine kinase conversion factor
has related synonym: kininase Ia
has related synonym: plasma carboxypeptidase B
id: GO:0004184
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

serine-type carboxypeptidase activity
IAO_0000115: Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
has db xref: EC:3.4.16
has db xref: Reactome:REACT_109426
has db xref: Reactome:REACT_6
has db xref: Reactome:REACT_79406
has db xref: Reactome:REACT_83670
has db xref: Reactome:REACT_92499
has db xref: Reactome:REACT_95826
has db xref: Reactome:REACT_98506
has exact synonym: serine carboxypeptidase activity
has OBO namespace: molecular_function
id: GO:0004185
in subset: gosubset prok
type: Class
subclass of: carboxypeptidase activity
subclass of: GO_0070008

carboxypeptidase C activity
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.
IAO_0100001: GO:0004185
has db xref: EC:3.4.16.5
has db xref: MetaCyc:3.4.16.5-RXN
has exact synonym: carboxypeptidase Y activity
has exact synonym: serine carboxypeptidase I activity
has exact synonym: serine-type carboxypeptidase I activity
has narrow synonym: cathepsin A activity
has narrow synonym: lysosomal carboxypeptidase A
has narrow synonym: lysosomal protective protein activity
has narrow synonym: vacuolar carboxypeptidase Y
has OBO namespace: molecular_function
has related synonym: deamidase
id: GO:0004186
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

carboxypeptidase D activity
IAO_0000115: OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.
IAO_0100001: GO:0004185
has db xref: EC:3.4.16.6
has db xref: MetaCyc:3.4.16.6-RXN
has exact synonym: KEX1 carboxypeptidase activity
has exact synonym: KEX1 proteinase activity
has exact synonym: carboxypeptidase S1 activity
has narrow synonym: carboxypeptidase KEX1 activity
has narrow synonym: gene KEX1 serine carboxypeptidase
has OBO namespace: molecular_function
has related synonym: CPDW-II
has related synonym: KEX1DELTAp
has related synonym: carboxypeptidase Kex1
has related synonym: cereal serine carboxypeptidase II
has related synonym: saccharomyces cerevisiae KEX1 gene product
id: GO:0004187
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

serine-type Pro-X carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
IAO_0100001: GO:0004185
has alternative id: GO:0008323
has db xref: EC:3.4.16.2
has db xref: MetaCyc:3.4.16.2-RXN
has exact synonym: aminoacylproline carboxypeptidase activity
has exact synonym: lysosomal Pro-Xaa carboxypeptidase activity
has exact synonym: peptidylprolylamino acid carboxypeptidase activity
has exact synonym: proline carboxypeptidase activity
has exact synonym: prolyl carboxypeptidase activity
has narrow synonym: angiotensinase C activity
has narrow synonym: lysosomal Pro-X carboxypeptidase activity
has narrow synonym: lysosomal carboxypeptidase C activity
has OBO namespace: molecular_function
has related synonym: PCP
has related synonym: proline-specific carboxypeptidase P
id: GO:0004188
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

tubulinyl-Tyr carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
IAO_0100001: GO:0004181
has db xref: EC:3.4.17.17
has db xref: MetaCyc:3.4.17.17-RXN
has exact synonym: TTCPase activity
has exact synonym: brain I carboxypeptidase activity
has exact synonym: carboxypeptidase-tubulin activity
has exact synonym: tubulin carboxypeptidase activity
has exact synonym: tubulin-tyrosine carboxypeptidase activity
has exact synonym: tubulinyl-tyrosine carboxypeptidase activity
has exact synonym: tubulinyltyrosine carboxypeptidase activity
has exact synonym: tyrosinotubulin carboxypeptidase activity
has exact synonym: tyrosyltubulin carboxypeptidase activity
has OBO namespace: molecular_function
has related synonym: soluble carboxypeptidase activity
id: GO:0004189
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

aspartic-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
has db xref: EC:3.4.23
has db xref: Reactome:REACT_100150
has db xref: Reactome:REACT_100746
has db xref: Reactome:REACT_102828
has db xref: Reactome:REACT_103663
has db xref: Reactome:REACT_103855
has db xref: Reactome:REACT_106913
has db xref: Reactome:REACT_108687
has db xref: Reactome:REACT_108752
has db xref: Reactome:REACT_110055
has db xref: Reactome:REACT_114839
has db xref: Reactome:REACT_114927
has db xref: Reactome:REACT_1306
has db xref: Reactome:REACT_1784
has db xref: Reactome:REACT_1803
has db xref: Reactome:REACT_28604
has db xref: Reactome:REACT_29012
has db xref: Reactome:REACT_29591
has db xref: Reactome:REACT_30254
has db xref: Reactome:REACT_32331
has db xref: Reactome:REACT_34376
has db xref: Reactome:REACT_77061
has db xref: Reactome:REACT_78562
has db xref: Reactome:REACT_78689
has db xref: Reactome:REACT_80559
has db xref: Reactome:REACT_82242
has db xref: Reactome:REACT_82441
has db xref: Reactome:REACT_89773
has db xref: Reactome:REACT_89990
has db xref: Reactome:REACT_93093
has db xref: Reactome:REACT_93980
has db xref: Reactome:REACT_95514
has db xref: Reactome:REACT_96133
has db xref: Reactome:REACT_96159
has db xref: Reactome:REACT_965
has db xref: Reactome:REACT_97765
has exact synonym: aspartate protease activity
has exact synonym: aspartic endopeptidase activity
has exact synonym: aspartic protease activity
has exact synonym: aspartyl protease activity
has exact synonym: carboxyl protease activity
has OBO namespace: molecular_function
id: GO:0004190
in subset: gosubset prok
type: Class
subclass of: endopeptidase activity
subclass of: GO_0070001

barrierpepsin activity
IAO_0000115: OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.
IAO_0100001: GO:0004190
has db xref: EC:3.4.23.35
has db xref: MetaCyc:3.4.23.35-RXN
has exact synonym: barrier proteinase activity
has narrow synonym: Bar proteinase activity
has OBO namespace: molecular_function
has related synonym: extracellular 'barrier' protein activity
id: GO:0004191
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cathepsin D activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
IAO_0100001: GO:0004190
has db xref: EC:3.4.23.5
has db xref: MetaCyc:3.4.23.5-RXN
has OBO namespace: molecular_function
id: GO:0004192
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cathepsin E activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.
IAO_0100001: GO:0004190
has db xref: EC:3.4.23.34
has db xref: MetaCyc:3.4.23.34-RXN
has exact synonym: cathepsin D-like acid proteinase activity
has exact synonym: cathepsin D-type proteinase activity
has exact synonym: cathepsin E-like acid proteinase activity
has exact synonym: non-pepsin proteinase activity
has narrow synonym: erythrocyte membrane aspartic proteinase activity
has OBO namespace: molecular_function
has related synonym: EMAP
has related synonym: SMP
has related synonym: slow-moving proteinase activity
id: GO:0004193
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

pepsin A activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.
IAO_0100001: GO:0004190
has broad synonym: pepsin activity
has db xref: EC:3.4.23.1
has db xref: MetaCyc:3.4.23.1-RXN
has OBO namespace: molecular_function
has related synonym: P I
has related synonym: P II
has related synonym: elixir lactate of pepsin
has related synonym: fundus-pepsin
has related synonym: lactated pepsin
has related synonym: lactated pepsin elixir
has related synonym: pepsin D
has related synonym: pepsin R
has related synonym: pepsin fortior
id: GO:0004194
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

renin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.
IAO_0100001: GO:0004190
has db xref: EC:3.4.23.15
has db xref: MetaCyc:3.4.23.15-RXN
has exact synonym: angiotensin-forming enzyme activity
has exact synonym: angiotensinogenase activity
has OBO namespace: molecular_function
id: GO:0004195
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

saccharopepsin activity
IAO_0000115: OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.
IAO_0100001: GO:0004190
has db xref: EC:3.4.23.25
has db xref: MetaCyc:3.4.23.25-RXN
has exact synonym: saccharomyces aspartic proteinase activity
has narrow synonym: Saccharomyces aspartic proteinase activity
has narrow synonym: yeast endopeptidase A activity
has OBO namespace: molecular_function
has related synonym: PRA
has related synonym: aspartic proteinase yscA
has related synonym: proteinase A
has related synonym: proteinase yscA
has related synonym: saccharomyces cerevisiae aspartic proteinase A
has related synonym: yeast proteinase A
id: GO:0004196
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cysteine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
has db xref: EC:3.4.22
has db xref: Reactome:REACT_100050
has db xref: Reactome:REACT_100093
has db xref: Reactome:REACT_100258
has db xref: Reactome:REACT_100371
has db xref: Reactome:REACT_100591
has db xref: Reactome:REACT_100749
has db xref: Reactome:REACT_100786
has db xref: Reactome:REACT_100806
has db xref: Reactome:REACT_101275
has db xref: Reactome:REACT_101388
has db xref: Reactome:REACT_101482
has db xref: Reactome:REACT_101496
has db xref: Reactome:REACT_101535
has db xref: Reactome:REACT_101617
has db xref: Reactome:REACT_102211
has db xref: Reactome:REACT_102224
has db xref: Reactome:REACT_102308
has db xref: Reactome:REACT_102448
has db xref: Reactome:REACT_102624
has db xref: Reactome:REACT_102731
has db xref: Reactome:REACT_102903
has db xref: Reactome:REACT_103130
has db xref: Reactome:REACT_103265
has db xref: Reactome:REACT_103288
has db xref: Reactome:REACT_103478
has db xref: Reactome:REACT_103480
has db xref: Reactome:REACT_103527
has db xref: Reactome:REACT_103538
has db xref: Reactome:REACT_103796
has db xref: Reactome:REACT_103879
has db xref: Reactome:REACT_103993
has db xref: Reactome:REACT_103997
has db xref: Reactome:REACT_104056
has db xref: Reactome:REACT_104095
has db xref: Reactome:REACT_104234
has db xref: Reactome:REACT_104249
has db xref: Reactome:REACT_104338
has db xref: Reactome:REACT_104344
has db xref: Reactome:REACT_104391
has db xref: Reactome:REACT_104407
has db xref: Reactome:REACT_104493
has db xref: Reactome:REACT_104700
has db xref: Reactome:REACT_104895
has db xref: Reactome:REACT_105045
has db xref: Reactome:REACT_105170
has db xref: Reactome:REACT_105481
has db xref: Reactome:REACT_105581
has db xref: Reactome:REACT_105957
has db xref: Reactome:REACT_105958
has db xref: Reactome:REACT_106680
has db xref: Reactome:REACT_107019
has db xref: Reactome:REACT_107128
has db xref: Reactome:REACT_107302
has db xref: Reactome:REACT_107511
has db xref: Reactome:REACT_107529
has db xref: Reactome:REACT_107629
has db xref: Reactome:REACT_107758
has db xref: Reactome:REACT_107853
has db xref: Reactome:REACT_108026
has db xref: Reactome:REACT_108198
has db xref: Reactome:REACT_108258
has db xref: Reactome:REACT_108537
has db xref: Reactome:REACT_108621
has db xref: Reactome:REACT_108783
has db xref: Reactome:REACT_108820
has db xref: Reactome:REACT_108938
has db xref: Reactome:REACT_108946
has db xref: Reactome:REACT_109026
has db xref: Reactome:REACT_109078
has db xref: Reactome:REACT_109269
has db xref: Reactome:REACT_109374
has db xref: Reactome:REACT_109414
has db xref: Reactome:REACT_109547
has db xref: Reactome:REACT_109908
has db xref: Reactome:REACT_110043
has db xref: Reactome:REACT_110086
has db xref: Reactome:REACT_110544
has db xref: Reactome:REACT_110842

calcium-dependent cysteine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
has narrow synonym: calpain activity
has OBO namespace: molecular_function
id: GO:0004198
in subset: gosubset prok
type: Class
subclass of: cysteine-type endopeptidase activity

signaling (initiator) caspase activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
consider: GO:0006915
has exact synonym: signalling (initiator) caspase activity
has OBO namespace: molecular_function
id: GO:0004200
type: Class
comment: This term was made obsolete because it includes biological process information.
deprecated: true

caspase-1 activity
IAO_0000115: OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec.
IAO_0100001: GO:0004197
has broad synonym: ICE
has OBO namespace: molecular_function
id: GO:0004201
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-2 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004202
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-4 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004203
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-5 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004204
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-8 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004205
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-10 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004206
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

effector caspase activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
consider: GO:0006915
has OBO namespace: molecular_function
id: GO:0004207
type: Class
comment: This term was made obsolete because it includes biological process information.
deprecated: true

caspase-3 activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis.
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004208
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-6 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004209
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-7 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004210
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

caspase-9 activity
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
IAO_0100001: GO:0004197
has OBO namespace: molecular_function
id: GO:0004211
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

lysosomal cysteine-type endopeptidase
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0004197
consider: GO:0005764
has OBO namespace: molecular_function
id: GO:0004212
type: Class
comment: This term was made obsolete because it contains both component and function information.
deprecated: true

cathepsin B activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
IAO_0100001: GO:0004197
has db xref: EC:3.4.22.1
has db xref: MetaCyc:3.4.22.1-RXN
has exact synonym: cathepsin B1 activity
has OBO namespace: molecular_function
has related synonym: cathepsin II
id: GO:0004213
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

dipeptidyl-peptidase I activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.
IAO_0100001: GO:0008234
IAO_0100001: GO:0008239
has db xref: EC:3.4.14.1
has db xref: MetaCyc:3.4.14.1-RXN
has exact synonym: cathepsin C activity
has exact synonym: cathepsin J activity
has exact synonym: dipeptidyl aminopeptidase I activity
has exact synonym: dipeptidyl transferase activity
has OBO namespace: molecular_function
has related synonym: DAP I
has related synonym: dipeptide arylamidase I
id: GO:0004214
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cathepsin H activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.
IAO_0100001: GO:0004197
has db xref: EC:3.4.22.16
has db xref: MetaCyc:3.4.22.16-RXN
has exact synonym: N-benzoylarginine-beta-naphthylamide hydrolase activity
has exact synonym: aleurain activity
has exact synonym: benzoylarginine-naphthylamide (BANA) hydrolase activity
has exact synonym: cathepsin B3 activity
has exact synonym: cathepsin BA activity
has OBO namespace: molecular_function
has related synonym: cathepsin Ba
id: GO:0004215
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cathepsin K activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
IAO_0100001: GO:0004197
has db xref: EC:3.4.22.38
has db xref: MetaCyc:3.4.22.38-RXN
has exact synonym: cathepsin O activity
has exact synonym: cathepsin O2 activity
has exact synonym: cathepsin X activity
has OBO namespace: molecular_function
id: GO:0004216
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cathepsin L activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
IAO_0100001: GO:0004197
has db xref: EC:3.4.22.15
has db xref: MetaCyc:3.4.22.15-RXN
has narrow synonym: Aldrichina grahami cysteine proteinase
has OBO namespace: molecular_function
id: GO:0004217
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cathepsin S activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.
IAO_0100001: GO:0004197
has db xref: EC:3.4.22.27
has db xref: MetaCyc:3.4.22.27-RXN
has OBO namespace: molecular_function
id: GO:0004218
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

pyroglutamyl-peptidase I activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.
IAO_0100001: GO:0008234
IAO_0100001: GO:0016920
has db xref: EC:3.4.19.3
has db xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN
has exact synonym: 5-oxoprolyl-peptidase activity
has exact synonym: L-pyroglutamyl peptide hydrolase activity
has exact synonym: L-pyrrolidonecarboxylate peptidase activity
has exact synonym: PYRase activity
has exact synonym: pyroglutamate aminopeptidase activity
has exact synonym: pyroglutamidase activity
has exact synonym: pyroglutamyl aminopeptidase activity
has exact synonym: pyrrolidone carboxyl peptidase activity
has exact synonym: pyrrolidone-carboxyl peptidase activity
has exact synonym: pyrrolidone-carboxylate peptidase activity
has exact synonym: pyrrolidonecarboxylyl peptidase activity
has exact synonym: pyrrolidonyl peptidase activity
has OBO namespace: molecular_function
id: GO:0004219
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

ubiquitin thiolesterase activity
IAO_0000115: Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
has alternative id: GO:0008577
has db xref: EC:3.1.2.15
has db xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN
has exact synonym: ubiquitin carboxy-terminal esterase activity
has exact synonym: ubiquitin thioesterase activity
has exact synonym: ubiquitin-C-terminal-thioester hydrolase activity
has narrow synonym: ubiquitinyl hydrolase 1 activity
has OBO namespace: molecular_function
has related synonym: ubiquitin C-terminal hydrolase activity
has related synonym: ubiquitin carboxy-terminal hydrolase activity
id: GO:0004221
in subset: gosubset prok
type: Class
comment: Note that this term is distinguished from 'ubiquitin-specific protease activity ; GO:0004843' in that it specifically refers to hydrolysis of thiolester bonds, but encompasses the removal of any substrate attached to ubiquitin via a thiolester bond.
subclass of: GO_0016790

metalloendopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
has db xref: EC:3.4.24
has db xref: Reactome:REACT_100500
has db xref: Reactome:REACT_102187
has db xref: Reactome:REACT_102738
has db xref: Reactome:REACT_104692
has db xref: Reactome:REACT_104704
has db xref: Reactome:REACT_105137
has db xref: Reactome:REACT_105311
has db xref: Reactome:REACT_109473
has db xref: Reactome:REACT_11089
has db xref: Reactome:REACT_111084
has db xref: Reactome:REACT_111197
has db xref: Reactome:REACT_11130
has db xref: Reactome:REACT_11146
has db xref: Reactome:REACT_11158
has db xref: Reactome:REACT_11165
has db xref: Reactome:REACT_11179
has db xref: Reactome:REACT_11195
has db xref: Reactome:REACT_115618
has db xref: Reactome:REACT_115992
has db xref: Reactome:REACT_13407
has db xref: Reactome:REACT_15304
has db xref: Reactome:REACT_15447
has db xref: Reactome:REACT_15475
has db xref: Reactome:REACT_28155
has db xref: Reactome:REACT_28465
has db xref: Reactome:REACT_30819
has db xref: Reactome:REACT_30876
has db xref: Reactome:REACT_31204
has db xref: Reactome:REACT_31767
has db xref: Reactome:REACT_32065
has db xref: Reactome:REACT_33032
has db xref: Reactome:REACT_33649
has db xref: Reactome:REACT_34637
has db xref: Reactome:REACT_46117
has db xref: Reactome:REACT_48941
has db xref: Reactome:REACT_79685
has db xref: Reactome:REACT_81221
has db xref: Reactome:REACT_83047
has db xref: Reactome:REACT_84535
has db xref: Reactome:REACT_85568
has db xref: Reactome:REACT_85944
has db xref: Reactome:REACT_87955
has db xref: Reactome:REACT_89938
has db xref: Reactome:REACT_9030
has db xref: Reactome:REACT_90847
has db xref: Reactome:REACT_91391
has db xref: Reactome:REACT_93439
has db xref: Reactome:REACT_9423
has db xref: Reactome:REACT_96741
has db xref: Reactome:REACT_97379
has db xref: Reactome:REACT_97836
has db xref: Reactome:REACT_98257
has db xref: Reactome:REACT_98581
has exact synonym: metalloendoprotease activity
has exact synonym: metalloendoproteinase activity
has OBO namespace: molecular_function
id: GO:0004222
in subset: gosubset prok
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008237

Gly-X carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.
IAO_0100001: GO:0004181
has db xref: EC:3.4.17.4
has db xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
has exact synonym: Gly-Xaa carboxypeptidase activity
has exact synonym: carboxypeptidase S activity
has exact synonym: glycine carboxypeptidase activity
has exact synonym: yeast carboxypeptidase activity
has OBO namespace: molecular_function
has related synonym: carboxypeptidase a
has related synonym: peptidase alpha
id: GO:0004226
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

gelatinase A activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.
IAO_0100001: GO:0004222
has broad synonym: type IV collagen metalloproteinase
has db xref: EC:3.4.24.24
has db xref: MetaCyc:3.4.24.24-RXN
has exact synonym: 3/4 collagenase activity
has exact synonym: MMP-2
has exact synonym: matrix metalloproteinase 2 activity
has exact synonym: type IV collagenase activity
has exact synonym: type IV collagenase/gelatinase activity
has narrow synonym: 72-kDa gelatinase activity
has OBO namespace: molecular_function
has related synonym: 72 kDa gelatinase type A
has related synonym: MMP 2
has related synonym: collagenase IV
has related synonym: collagenase type IV
has related synonym: matrix metalloproteinase 5
id: GO:0004228
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

gelatinase B activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.
IAO_0100001: GO:0004222
has broad synonym: type IV collagen metalloproteinase
has db xref: EC:3.4.24.35
has db xref: MetaCyc:3.4.24.35-RXN
has exact synonym: 95 kDa type IV collagenase/gelatinase activity
has exact synonym: MMP-9
has exact synonym: matrix metalloproteinase 9 activity
has exact synonym: type V collagenase activity
has narrow synonym: 92-kDa gelatinase activity
has narrow synonym: 92-kDa type IV collagenase activity
has narrow synonym: macrophage gelatinase activity
has OBO namespace: molecular_function
has related synonym: MMP 9
has related synonym: collagenase IV
has related synonym: collagenase type IV
has related synonym: gelatinase MMP 9
id: GO:0004229
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

glutamyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
IAO_0100001: GO:0004177
IAO_0100001: GO:0008235
has db xref: EC:3.4.11.7
has db xref: MetaCyc:3.4.11.7-RXN
has exact synonym: Ca2+-activated glutamate aminopeptidase activity
has exact synonym: L-aspartate aminopeptidase activity
has exact synonym: aspartate aminopeptidase activity
has exact synonym: glutamyl peptidase activity
has OBO namespace: molecular_function
has related synonym: aminopeptidase A
has related synonym: angiotensinase A
has related synonym: angiotensinase A2
has related synonym: antigen BP-1/6C3 of mouse B lymphocytes
has related synonym: membrane aminopeptidase II
id: GO:0004230
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

insulysin activity
IAO_0000115: OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.56
has db xref: MetaCyc:3.4.24.56-RXN
has exact synonym: insulin protease activity
has exact synonym: insulin proteinase activity
has exact synonym: insulin-degrading enzyme activity
has exact synonym: insulin-degrading neutral proteinase activity
has exact synonym: insulin-glucagon protease activity
has exact synonym: insulin-specific protease activity
has exact synonym: insulinase activity
has exact synonym: metalloinsulinase activity
has OBO namespace: molecular_function
has related synonym: IDE
id: GO:0004231
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

interstitial collagenase activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
IAO_0100001: GO:0004252
has db xref: EC:3.4.24.7
has db xref: MetaCyc:3.4.24.7-RXN
has exact synonym: MMP-1
has exact synonym: matrix metalloproteinase 1
has exact synonym: vertebrate collagenase activity
has OBO namespace: molecular_function
id: GO:0004232
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

macrophage elastase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.
IAO_0100001: GO:0004175
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.65
has db xref: MetaCyc:3.4.24.65-RXN
has exact synonym: MMP-12
has exact synonym: human macrophage metalloelastase (HME)
has exact synonym: matrix metalloproteinase 12 activity
has exact synonym: metalloelastase activity
has exact synonym: metalloesterase activity
has OBO namespace: molecular_function
id: GO:0004234
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

matrilysin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.23
has db xref: MetaCyc:3.4.24.23-RXN
has exact synonym: MMP-7
has exact synonym: PUMP-1 proteinase activity
has exact synonym: matrin activity
has exact synonym: matrix metalloproteinase 7 activity
has exact synonym: putative metalloproteinase activity
has narrow synonym: PUMP-1 activity
has narrow synonym: putative (or punctuated) metalloproteinase-1 activity
has narrow synonym: uterine metalloendopeptidase activity
has OBO namespace: molecular_function
has related synonym: MMP
has related synonym: MMP 7
has related synonym: PUMP
has related synonym: matrix metalloproteinase pump 1
has related synonym: metalloproteinase pump-1
id: GO:0004235
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

membrane dipeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of dipeptides.
IAO_0100001: GO:0008235
IAO_0100001: GO:0016805
has broad synonym: dipeptide hydrolase
has db xref: EC:3.4.13.19
has db xref: MetaCyc:3.4.13.19-RXN
has exact synonym: aminodipeptidase activity
has exact synonym: dehydropeptidase I activity
has exact synonym: dipeptidyl hydrolase activity
has exact synonym: glycosyl-phosphatidylinositol-anchored renal dipeptidase activity
has exact synonym: nonspecific dipeptidase activity
has narrow synonym: DPH I activity
has narrow synonym: microsomal dipeptidase activity
has narrow synonym: renal dipeptidase activity
has OBO namespace: molecular_function
has related synonym: MDP
has related synonym: dehydropeptidase I (DPH I)
id: GO:0004237
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

meprin A activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
IAO_0100001: GO:0004222
has broad synonym: endopeptidase-2 activity
has db xref: EC:3.4.24.18
has db xref: MetaCyc:3.4.24.18-RXN
has exact synonym: N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity
has exact synonym: PABA-peptide hydrolase activity
has OBO namespace: molecular_function
has related synonym: PPH
has related synonym: meprin
has related synonym: meprin-a
id: GO:0004238
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

methionyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
IAO_0100001: GO:0004177
IAO_0100001: GO:0008235
consider: GO:0070084
has db xref: EC:3.4.11.18
has db xref: MetaCyc:3.4.11.18-RXN
has exact synonym: L-methionine aminopeptidase activity
has exact synonym: methionine aminopeptidase activity
has exact synonym: peptidase M activity
has OBO namespace: molecular_function
has related synonym: MAP
id: GO:0004239
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

mitochondrial processing peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.64
has db xref: MetaCyc:3.4.24.64-RXN
has exact synonym: MPP
has exact synonym: mitochondrial protein precursor-processing proteinase activity
has narrow synonym: alpha-mitochondrial processing peptidase
has narrow synonym: beta-mitochondrial processing peptidase
has narrow synonym: processing enhancing peptidase activity
has OBO namespace: molecular_function
has related synonym: matrix peptidase
has related synonym: matrix processing peptidase
has related synonym: matrix processing proteinase
has related synonym: processing enhancing peptidase (for one of two subunits)
id: GO:0004240
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

alpha-mitochondrial processing peptidase
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0004222
consider: GO:0005739
has exact synonym: alpha-MPP
has OBO namespace: molecular_function
id: GO:0004241
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

beta-mitochondrial processing peptidase
IAO_0000115: OBSOLETE (was not defined before being made obsolete).
consider: GO:0004222
consider: GO:0005739
has exact synonym: beta-MPP
has OBO namespace: molecular_function
id: GO:0004242
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

mitochondrial intermediate peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.
IAO_0100001: GO:0004222
has broad synonym: MIP
has db xref: EC:3.4.24.59
has db xref: MetaCyc:3.4.24.59-RXN
has exact synonym: mitochondrial intermediate precursor-processing proteinase activity
has OBO namespace: molecular_function
id: GO:0004243
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

mitochondrial inner membrane peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.
IAO_0100001: GO:0004175
has broad synonym: IMP
has db xref: EC:3.4.99.-
has OBO namespace: molecular_function
id: GO:0004244
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

neprilysin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
IAO_0100001: GO:0004222
has broad synonym: endopeptidase-2 activity
has db xref: EC:3.4.24.11
has db xref: MetaCyc:3.4.24.11-RXN
has exact synonym: enkephalinase activity
has exact synonym: neutral endopeptidase activity
has exact synonym: neutral metallendopeptidase activity
has narrow synonym: kidney-brush-border neutral endopeptidase
has narrow synonym: kidney-brush-border neutral peptidase
has narrow synonym: kidney-brush-border neutral proteinase activity
has narrow synonym: membrane metalloendopeptidase activity
has OBO namespace: molecular_function
has related synonym: CALLA
has related synonym: CALLA (common acute lymphoblastic leukemia-associated) antigens
has related synonym: CALLA antigen
has related synonym: CALLA glycoprotein
has related synonym: CALLA glycoproteins
has related synonym: CD10
has related synonym: acute lymphoblastic leukemia antigen
has related synonym: common acute lymphoblastic leukemia antigen
has related synonym: common acute lymphoblastic leukemia-associated antigens
has related synonym: endopeptidase 24.11
has related synonym: neutral endopeptidase 24.11
id: GO:0004245
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

peptidyl-dipeptidase A activity
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
IAO_0100001: GO:0008237
IAO_0100001: GO:0008241
has broad synonym: ACE activity
has broad synonym: dipeptide hydrolase
has db xref: EC:3.4.15.1
has db xref: MetaCyc:3.4.15.1-RXN
has exact synonym: angiotensin I-converting enzyme activity
has exact synonym: carboxycathepsin activity
has exact synonym: dipeptidyl carboxypeptidase I activity
has exact synonym: endothelial cell peptidyl dipeptidase activity
has exact synonym: kininase II activity
has exact synonym: peptidase P activity
has exact synonym: peptidyl dipeptidase I activity
has exact synonym: peptidyl dipeptide hydrolase activity
has exact synonym: peptidyl-dipeptide hydrolase activity
has exact synonym: peptidyldipeptide hydrolase activity
has OBO namespace: molecular_function
has related synonym: DCP
has related synonym: PDH
has related synonym: angiotensin converting enzyme
has related synonym: peptidyl dipeptidase A
has related synonym: peptidyl dipeptidase-4
id: GO:0004246
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

saccharolysin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.37
has db xref: MetaCyc:3.4.24.37-RXN
has narrow synonym: oligopeptidase yscD activity
has narrow synonym: proteinase yscD activity
has narrow synonym: yeast cysteine proteinase D activity
has OBO namespace: molecular_function
has related synonym: saccharomyces cerevisiae proteinase yscD
id: GO:0004247
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

stromelysin 1 activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.17
has db xref: MetaCyc:3.4.24.17-RXN
has exact synonym: MMP-3
has exact synonym: matrix metalloproteinase 3 activity
has exact synonym: neutral proteoglycanase activity
has exact synonym: proteoglycanase activity
has exact synonym: transin activity
has OBO namespace: molecular_function
has related synonym: collagen-activating protein
has related synonym: collagenase activating protein
has related synonym: procollagenase activator
has related synonym: stromelysin
id: GO:0004248
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

stromelysin 3 activity
IAO_0000115: OBSOLETE. Was not defined before being made obsolete.
IAO_0100001: GO:0004222
has db xref: EC:3.4.24.-
has exact synonym: MMP-11
has exact synonym: matrix metalloproteinase 11
has OBO namespace: molecular_function
id: GO:0004249
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

aminopeptidase I activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.
IAO_0100001: GO:0004177
IAO_0100001: GO:0008235
has db xref: EC:3.4.11.22
has db xref: MetaCyc:3.4.11.22-RXN
has exact synonym: aminopeptidase III activity
has exact synonym: leucine aminopeptidase IV activity
has narrow synonym: aminopeptidase yscI activity
has narrow synonym: vacuolar aminopeptidase I activity
has OBO namespace: molecular_function
has related synonym: yeast aminopeptidase I
id: GO:0004250
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

X-Pro dipeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
IAO_0100001: GO:0008235
IAO_0100001: GO:0016805
has db xref: EC:3.4.13.9
has db xref: MetaCyc:3.4.13.9-RXN
has exact synonym: Xaa-Pro dipeptidase activity
has exact synonym: gamma-peptidase activity
has exact synonym: imidodipeptidase activity
has exact synonym: prolidase activity
has exact synonym: proline dipeptidase activity
has OBO namespace: molecular_function
has related synonym: peptidase D
id: GO:0004251
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

serine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
has db xref: EC:3.4.21
has db xref: Reactome:REACT_100031
has db xref: Reactome:REACT_100125
has db xref: Reactome:REACT_100194
has db xref: Reactome:REACT_100271
has db xref: Reactome:REACT_100321
has db xref: Reactome:REACT_10058
has db xref: Reactome:REACT_100669
has db xref: Reactome:REACT_100764
has db xref: Reactome:REACT_100842
has db xref: Reactome:REACT_100919
has db xref: Reactome:REACT_100938
has db xref: Reactome:REACT_101008
has db xref: Reactome:REACT_101012
has db xref: Reactome:REACT_101033
has db xref: Reactome:REACT_101265
has db xref: Reactome:REACT_101293
has db xref: Reactome:REACT_101358
has db xref: Reactome:REACT_101408
has db xref: Reactome:REACT_101486
has db xref: Reactome:REACT_101710
has db xref: Reactome:REACT_102047
has db xref: Reactome:REACT_102222
has db xref: Reactome:REACT_102226
has db xref: Reactome:REACT_102247
has db xref: Reactome:REACT_102300
has db xref: Reactome:REACT_102318
has db xref: Reactome:REACT_102435
has db xref: Reactome:REACT_102450
has db xref: Reactome:REACT_102555
has db xref: Reactome:REACT_102564
has db xref: Reactome:REACT_102660
has db xref: Reactome:REACT_102717
has db xref: Reactome:REACT_102762
has db xref: Reactome:REACT_103193
has db xref: Reactome:REACT_103297
has db xref: Reactome:REACT_103317
has db xref: Reactome:REACT_103386
has db xref: Reactome:REACT_103434
has db xref: Reactome:REACT_103529
has db xref: Reactome:REACT_103532
has db xref: Reactome:REACT_103534
has db xref: Reactome:REACT_103821
has db xref: Reactome:REACT_104063
has db xref: Reactome:REACT_104096
has db xref: Reactome:REACT_104436
has db xref: Reactome:REACT_104461
has db xref: Reactome:REACT_104513
has db xref: Reactome:REACT_104582
has db xref: Reactome:REACT_104633
has db xref: Reactome:REACT_104789
has db xref: Reactome:REACT_104808
has db xref: Reactome:REACT_104872
has db xref: Reactome:REACT_104930
has db xref: Reactome:REACT_105381
has db xref: Reactome:REACT_105667
has db xref: Reactome:REACT_105786
has db xref: Reactome:REACT_106150
has db xref: Reactome:REACT_106201
has db xref: Reactome:REACT_106288
has db xref: Reactome:REACT_106360
has db xref: Reactome:REACT_106442
has db xref: Reactome:REACT_1065
has db xref: Reactome:REACT_106545
has db xref: Reactome:REACT_106587
has db xref: Reactome:REACT_106621
has db xref: Reactome:REACT_106696
has db xref: Reactome:REACT_106726
has db xref: Reactome:REACT_106877
has db xref: Reactome:REACT_106997
has db xref: Reactome:REACT_107059
has db xref: Reactome:REACT_1071
has db xref: Reactome:REACT_107173
has db xref: Reactome:REACT_107386
has db xref: Reactome:REACT_107456
has db xref: Reactome:REACT_107494
has db xref: Reactome:REACT_107597
has db xref: Reactome:REACT_107831
has db xref: Reactome:REACT_107946

gamma-renin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.54
has db xref: MetaCyc:3.4.21.54-RXN
has OBO namespace: molecular_function
id: GO:0004253
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

acylaminoacyl-peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.
IAO_0100001: GO:0004252
has db xref: EC:3.4.19.1
has db xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN
has exact synonym: N-acylpeptide hydrolase activity
has exact synonym: N-formylmethionine (fMet) aminopeptidase activity
has exact synonym: acylamino-acid-releasing enzyme activity
has exact synonym: alpha-N-acylpeptide hydrolase activity
has OBO namespace: molecular_function
id: GO:0004254
in subset: gosubset prok
type: Class
deprecated: true

vacuolar carboxypeptidase Y
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.
consider: GO:0004185
consider: GO:0005773
has OBO namespace: molecular_function
id: GO:0004258
type: Class
comment: This term was made obsolete because it contains both component and function information.
deprecated: true

cathepsin G activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.20
has db xref: MetaCyc:3.4.21.20-RXN
has exact synonym: chymotrypsin-like proteinase activity
has exact synonym: neutral proteinase activity
has OBO namespace: molecular_function
id: GO:0004261
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

cerevisin activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.48
has db xref: MetaCyc:3.4.21.48-RXN
has narrow synonym: brewer's yeast proteinase
has narrow synonym: proteinase yscB activity
has narrow synonym: yeast proteinase B activity
has OBO namespace: molecular_function
has related synonym: baker's yeast proteinase B
has related synonym: peptidase beta
id: GO:0004262
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

chymotrypsin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.1
has db xref: MetaCyc:3.4.21.1-RXN
has exact synonym: quimotrase activity
has narrow synonym: alpha-chymotrypsin activity
has narrow synonym: chymotrypsin A activity
has narrow synonym: chymotrypsin B activity
has OBO namespace: molecular_function
has related synonym: alpha-chymar
has related synonym: alpha-chymar ophth
has related synonym: alpha-chymotrypsin A
has related synonym: avazyme
has related synonym: chymar
has related synonym: chymotest
has related synonym: chymotrypsins A and B
has related synonym: enzeon
has related synonym: quimar
id: GO:0004263
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

dipeptidyl-peptidase IV activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
IAO_0100001: GO:0008236
IAO_0100001: GO:0008239
has db xref: EC:3.4.14.5
has db xref: MetaCyc:3.4.14.5-RXN
has exact synonym: DPP IV activity
has exact synonym: Gly-Pro naphthylamidase activity
has exact synonym: Xaa-Pro-dipeptidyl-aminopeptidase activity
has exact synonym: Xaa-Pro-dipeptidylaminopeptidase activity
has exact synonym: amino acyl-prolyl dipeptidyl aminopeptidase activity
has exact synonym: dipeptidyl aminopeptidase IV activity
has exact synonym: dipeptidyl-peptide hydrolase activity
has exact synonym: glycylproline aminopeptidase activity
has exact synonym: glycylprolyl aminopeptidase activity
has exact synonym: glycylprolyl dipeptidylaminopeptidase activity
has exact synonym: post-proline dipeptidyl aminopeptidase IV activity
has OBO namespace: molecular_function
has related synonym: DPP IV/CD26
has related synonym: T cell triggering molecule Tp103
has related synonym: X-PDAP
has related synonym: dipeptidyl peptidase IV
has related synonym: dipeptidyl-aminopeptidase IV
has related synonym: glycoprotein GP110
has related synonym: leukocyte antigen CD26
has related synonym: lymphocyte antigen CD26
has related synonym: pep X
has related synonym: postproline dipeptidyl aminopeptidase IV
id: GO:0004274
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

enteropeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.9
has db xref: MetaCyc:3.4.21.9-RXN
has OBO namespace: molecular_function
has related synonym: enterokinase activity
id: GO:0004275
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

furin activity
IAO_0000115: OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.75
has db xref: MetaCyc:3.4.21.75-RXN
has exact synonym: dibasic processing enzyme activity
has exact synonym: paired basic amino acid residue cleaving enzyme activity
has narrow synonym: prohormone convertase activity
has OBO namespace: molecular_function
has related synonym: PACE
has related synonym: SPC3
has related synonym: paired basic amino acid cleaving enzyme
has related synonym: paired basic amino acid converting enzyme
has related synonym: serine proteinase PACE
id: GO:0004276
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

granzyme A activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.78
has db xref: MetaCyc:3.4.21.78-RXN
has narrow synonym: T-cell derived serine proteinase
has narrow synonym: cytotoxic T lymphocyte serine protease
has narrow synonym: cytotoxic T-lymphocyte proteinase 1 activity
has OBO namespace: molecular_function
has related synonym: CTLA3
has related synonym: HuTPS
has related synonym: T-cell associated protease 1
has related synonym: TSP-1
id: GO:0004277
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

granzyme B activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.79
has db xref: MetaCyc:3.4.21.79-RXN
has narrow synonym: CCP1 proteinase
has narrow synonym: cytotoxic t-lymphocyte proteinase 2 activity
has OBO namespace: molecular_function
has related synonym: CCPII
has related synonym: CTLA1
has related synonym: cytotoxic cell proteinase-1
has related synonym: granzyme G
has related synonym: granzyme H
id: GO:0004278
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

pancreatic elastase II activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.71
has db xref: MetaCyc:3.4.21.71-RXN
has OBO namespace: molecular_function
has related synonym: pancreatic elastase 2
id: GO:0004281
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

plasmin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.7
has db xref: MetaCyc:3.4.21.7-RXN
has exact synonym: actase activity
has exact synonym: fibrinase activity
has exact synonym: fibrinolysin activity
has exact synonym: serum tryptase activity
has OBO namespace: molecular_function
has related synonym: thrombolysin
id: GO:0004283
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

acrosin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.10
has db xref: MetaCyc:3.4.21.10-RXN
has exact synonym: acrosin amidase activity
has exact synonym: acrosomal protease activity
has exact synonym: acrosomal proteinase activity
has exact synonym: acrozonase activity
has OBO namespace: molecular_function
has related synonym: alpha-acrosin
has related synonym: beta-acrosin
has related synonym: psi-acrosin
id: GO:0004284
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

proprotein convertase 1 activity
IAO_0000115: OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.93
has db xref: MetaCyc:3.4.21.93-RXN
has narrow synonym: NEC 1 activity
has narrow synonym: PC1 activity
has narrow synonym: neuroendocrine convertase 1 activity
has narrow synonym: prohormone convertase I activity
has OBO namespace: molecular_function
has related synonym: prohormone convertase 3
id: GO:0004285
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

proprotein convertase 2 activity
IAO_0000115: OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.94
has db xref: MetaCyc:3.4.21.94-RXN
has narrow synonym: NEC 2 activity
has narrow synonym: PC2 activity
has narrow synonym: neuroendocrine convertase 2 activity
has narrow synonym: prohormone convertase II activity
has OBO namespace: molecular_function
id: GO:0004286
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

prolyl oligopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.26
has db xref: MetaCyc:3.4.21.26-RXN
has exact synonym: endoprolylpeptidase activity
has exact synonym: post-proline cleaving enzyme activity
has exact synonym: post-proline endopeptidase activity
has exact synonym: proline endopeptidase activity
has exact synonym: proline-specific endopeptidase activity
has exact synonym: prolyl endopeptidase activity
has OBO namespace: molecular_function
id: GO:0004287
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

subtilase activity
IAO_0000115: OBSOLETE. Was not defined before being made obsolete.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.-
has OBO namespace: molecular_function
id: GO:0004289
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

kexin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.61
has db xref: MetaCyc:3.4.21.61-RXN
has exact synonym: paired-basic endopeptidase activity
has exact synonym: prohormone-processing proteinase activity
has narrow synonym: Kex 2p proteinase
has narrow synonym: Kex2 endopeptidase
has narrow synonym: Kex2 endoprotease
has narrow synonym: Kex2 endoproteinase
has narrow synonym: Kex2 protease
has narrow synonym: Kex2 proteinase
has narrow synonym: Kex2-like endoproteinase
has narrow synonym: Kex2-like precursor protein processing endoprotease
has narrow synonym: gene KEX2 dibasic proteinase
has narrow synonym: prohormone-processing KEX2 proteinase
has narrow synonym: proteinase yscF activity
has narrow synonym: yeast KEX2 protease activity
has OBO namespace: molecular_function
has related synonym: andrenorphin-Gly-generating enzyme
has related synonym: endoproteinase Kex2p
has related synonym: prohormone-processing endoprotease activity
has related synonym: protease KEX2
has related synonym: proteinase Kex2p
has related synonym: yeast cysteine proteinase F
id: GO:0004290
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

subtilisin activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
IAO_0100001: GO:0004252
has broad synonym: thermoase
has db xref: EC:3.4.21.62
has db xref: MetaCyc:3.4.21.62-RXN
has exact synonym: alcalase activity
has exact synonym: bacillus subtilis alkaline proteinase activity
has exact synonym: bacillus subtilis alkaline proteinase bioprase activity
has exact synonym: colistinase activity
has exact synonym: esperase activity
has exact synonym: kazusase activity
has exact synonym: maxatase activity
has exact synonym: savinase activity
has exact synonym: subtilopeptidase activity
has exact synonym: superase activity
has OBO namespace: molecular_function
has related synonym: ALK-enzyme
has related synonym: SP 266
has related synonym: alcalase 0.6L
has related synonym: alcalase 2.5L
has related synonym: bacillopeptidase A
has related synonym: bacillopeptidase B
has related synonym: bioprase AL 15
has related synonym: bioprase APL 30
has related synonym: genenase I
has related synonym: opticlean
has related synonym: orientase 10B
has related synonym: protease S
has related synonym: protease VIII
has related synonym: protease XXVII
has related synonym: protin A 3L
has related synonym: savinase 16.0L
has related synonym: savinase 32.0 L EX
has related synonym: savinase 4.0T
has related synonym: savinase 8.0L
has related synonym: subtilisin BL
has related synonym: subtilisin DY
has related synonym: subtilisin E
has related synonym: subtilisin GX
has related synonym: subtilisin J
has related synonym: subtilisin S41
has related synonym: subtilisin sendai
has related synonym: thermoase PC 10
id: GO:0004291
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

tissue kallikrein activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
IAO_0100001: GO:0004252
has alternative id: GO:0004279
has broad synonym: bradykininogenase
has broad synonym: kallidinogenase
has broad synonym: kininogenase
has db xref: EC:3.4.21.35
has db xref: MetaCyc:3.4.21.35-RXN
has OBO namespace: molecular_function
has related synonym: callicrein
has related synonym: depot-padutin
has related synonym: dilminal D
has related synonym: glandular kallikrein activity
has related synonym: glumorin
has related synonym: kallikrein
has related synonym: kidney kallikrein
has related synonym: kininogenin activity
has related synonym: onokrein P
has related synonym: padreatin
has related synonym: padutin
has related synonym: pancreatic kallikrein
has related synonym: salivary kallikrein
has related synonym: submandibular kallikrein
has related synonym: submaxillary kallikrein
has related synonym: urinary kallikrein
has related synonym: urokallikrein
id: GO:0004293
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

tripeptidyl-peptidase II activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.
IAO_0100001: GO:0008240
has broad synonym: tripeptidyl aminopeptidase activity
has broad synonym: tripeptidyl peptidase activity
has db xref: EC:3.4.14.10
has db xref: MetaCyc:3.4.14.10-RXN
has OBO namespace: molecular_function
has related synonym: TPP
has related synonym: tripeptidyl aminopeptidase II
has related synonym: tripeptidyl peptidase II
id: GO:0004294
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

trypsin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.
IAO_0100001: GO:0004252
has db xref: EC:3.4.21.4
has db xref: MetaCyc:3.4.21.4-RXN
has exact synonym: cocoonase activity
has exact synonym: sperm receptor hydrolase activity
has narrow synonym: alpha-trypsin activity
has narrow synonym: beta-trypsin activity
has OBO namespace: molecular_function
has related synonym: parenzyme
has related synonym: parenzymol
has related synonym: pseudotrypsin
has related synonym: tripcellim
has related synonym: tryptar
has related synonym: trypure
id: GO:0004295
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it represents a gene product.
deprecated: true

threonine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
has db xref: EC:3.4.25
has exact synonym: threonine endopeptidase activity
has narrow synonym: large multicatalytic protease
has narrow synonym: lens neutral proteinase
has narrow synonym: multicatalytic proteinase
has narrow synonym: multicatalytic proteinase (complex)
has narrow synonym: proteasome endopeptidase complex
has narrow synonym: tricorn protease
has narrow synonym: tricorn proteinase
has OBO namespace: molecular_function
has related synonym: 26S protease
has related synonym: MCP
has related synonym: alkaline protease
has related synonym: ingensin
has related synonym: multicatalytic endopeptidase complex
has related synonym: prosome
id: GO:0004298
in subset: gosubset prok
type: Class
subclass of: endopeptidase activity
subclass of: GO_0070003

proteasome endopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity.
consider: GO:0004175
consider: GO:0008233
has OBO namespace: molecular_function
has related synonym: multicatalytic endopeptidase
has related synonym: proteasome
has related synonym: proteasome endopeptidase complex
id: GO:0004299
type: Class
comment: This term was made obsolete because it mentions a component term in the text string.
deprecated: true

enoyl-CoA hydratase activity
IAO_0000115: Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
has alternative id: GO:0016510
has broad synonym: D-3-hydroxyacyl-CoA dehydratase
has broad synonym: enoyl coenzyme A hydrase (D)
has db xref: EC:4.2.1.17
has db xref: MetaCyc:ENOYL-COA-HYDRAT-RXN
has db xref: RHEA:16108
has db xref: Reactome:REACT_100244
has db xref: Reactome:REACT_101009
has db xref: Reactome:REACT_102396
has db xref: Reactome:REACT_103471
has db xref: Reactome:REACT_103986
has db xref: Reactome:REACT_104078
has db xref: Reactome:REACT_104151
has db xref: Reactome:REACT_104418
has db xref: Reactome:REACT_104448
has db xref: Reactome:REACT_105085
has db xref: Reactome:REACT_105300
has db xref: Reactome:REACT_105444
has db xref: Reactome:REACT_105604
has db xref: Reactome:REACT_106492
has db xref: Reactome:REACT_106863
has db xref: Reactome:REACT_107470
has db xref: Reactome:REACT_107615
has db xref: Reactome:REACT_107774
has db xref: Reactome:REACT_107955
has db xref: Reactome:REACT_1081
has db xref: Reactome:REACT_108453
has db xref: Reactome:REACT_109
has db xref: Reactome:REACT_109467
has db xref: Reactome:REACT_110285
has db xref: Reactome:REACT_110603
has db xref: Reactome:REACT_110864
has db xref: Reactome:REACT_1513
has db xref: Reactome:REACT_1582
has db xref: Reactome:REACT_2238
has db xref: Reactome:REACT_28724
has db xref: Reactome:REACT_28770
has db xref: Reactome:REACT_29458
has db xref: Reactome:REACT_297
has db xref: Reactome:REACT_31820
has db xref: Reactome:REACT_32105
has db xref: Reactome:REACT_32676
has db xref: Reactome:REACT_32695
has db xref: Reactome:REACT_32816
has db xref: Reactome:REACT_32949
has db xref: Reactome:REACT_33031
has db xref: Reactome:REACT_33248
has db xref: Reactome:REACT_33368
has db xref: Reactome:REACT_33412
has db xref: Reactome:REACT_33601
has db xref: Reactome:REACT_33795
has db xref: Reactome:REACT_34057
has db xref: Reactome:REACT_34615
has db xref: Reactome:REACT_34665
has db xref: Reactome:REACT_386
has db xref: Reactome:REACT_440
has db xref: Reactome:REACT_45972
has db xref: Reactome:REACT_52162
has db xref: Reactome:REACT_583
has db xref: Reactome:REACT_64
has db xref: Reactome:REACT_65800
has db xref: Reactome:REACT_77114
has db xref: Reactome:REACT_77283
has db xref: Reactome:REACT_78294
has db xref: Reactome:REACT_78515
has db xref: Reactome:REACT_78642
has db xref: Reactome:REACT_79462
has db xref: Reactome:REACT_79591
has db xref: Reactome:REACT_80706
has db xref: Reactome:REACT_80753
has db xref: Reactome:REACT_81483
has db xref: Reactome:REACT_82337
has db xref: Reactome:REACT_82344
has db xref: Reactome:REACT_83439
has db xref: Reactome:REACT_83846
has db xref: Reactome:REACT_84610
has db xref: Reactome:REACT_86074
has db xref: Reactome:REACT_86077
has db xref: Reactome:REACT_86167

epoxide hydrolase activity
IAO_0000115: Catalysis of the reaction: an epoxide + H2O = a glycol.
has broad synonym: arene-oxide hydratase activity
has broad synonym: aryl epoxide hydrase activity
has broad synonym: epoxide hydrase activity
has broad synonym: epoxide hydratase activity
has db xref: EC:3.3.2.10
has db xref: MetaCyc:3.3.2.10-RXN
has db xref: UM-BBD_enzymeID:e0397
has exact synonym: cytosolic epoxide hydrolase activity
has exact synonym: trans-stilbene oxide hydrolase activity
has narrow synonym: soluble epoxide hydrolase activity
has OBO namespace: molecular_function
has related synonym: sEH
id: GO:0004301
in subset: gosubset prok
type: Class
subclass of: GO_0016803

estradiol 17-beta-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
has broad synonym: 17-beta-HSD activity
has broad synonym: 17-beta-hydroxysteroid dehydrogenase activity
has broad synonym: 20alpha-hydroxysteroid dehydrogenase
has db xref: EC:1.1.1.62
has db xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
has db xref: Reactome:REACT_25243
has exact synonym: 17-beta-estradiol dehydrogenase activity
has exact synonym: 17beta,20alpha-hydroxysteroid dehydrogenase activity
has exact synonym: 17beta-estradiol dehydrogenase activity
has exact synonym: 17beta-hydroxysteroid dehydrogenase activity
has exact synonym: estradiol 17beta-dehydrogenase activity
has exact synonym: estradiol dehydrogenase activity
has exact synonym: estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
has exact synonym: estrogen 17-oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: 17beta-HSD
id: GO:0004303
type: Class
subclass of: GO_0033764

estrone sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
has broad synonym: estrogen sulfotransferase
has db xref: EC:2.8.2.4
has db xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN
has db xref: RHEA:15976
has db xref: Reactome:REACT_101309
has db xref: Reactome:REACT_102402
has db xref: Reactome:REACT_110189
has db xref: Reactome:REACT_113027
has db xref: Reactome:REACT_28523
has db xref: Reactome:REACT_28969
has db xref: Reactome:REACT_6874
has db xref: Reactome:REACT_80747
has db xref: Reactome:REACT_92523
has exact synonym: 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity
has exact synonym: 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity
has exact synonym: 3'-phosphoadenylylsulfate:oestrone sulfotransferase activity
has exact synonym: estrogen sulphotransferase activity
has exact synonym: estrone sulphotransferase activity
has exact synonym: oestrogen sulphotransferase activity
has OBO namespace: molecular_function
id: GO:0004304
type: Class
subclass of: GO_0008146

ethanolamine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.
has db xref: EC:2.7.1.82
has db xref: KEGG:R01468
has db xref: MetaCyc:ETHANOLAMINE-KINASE-RXN
has db xref: RHEA:13072
has exact synonym: ATP:ethanolamine O-phosphotransferase activity
has exact synonym: ethanolamine kinase (phosphorylating)
has exact synonym: ethanolamine phosphokinase activity
has OBO namespace: molecular_function
id: GO:0004305
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

ethanolamine-phosphate cytidylyltransferase activity
IAO_0000115: Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
has broad synonym: phosphorylethanolamine transferase activity
has db xref: EC:2.7.7.14
has db xref: MetaCyc:2.7.7.14-RXN
has db xref: RHEA:24595
has exact synonym: CTP-phosphoethanolamine cytidylyltransferase activity
has exact synonym: CTP:ethanolamine-phosphate cytidylyltransferase activity
has exact synonym: CTP:phosphoethanolamine cytidylyltransferase activity
has exact synonym: ethanolamine phosphate cytidylyltransferase activity
has exact synonym: phosphoethanolamine cytidylyltransferase activity
has OBO namespace: molecular_function
has related synonym: ET
id: GO:0004306
type: Class
subclass of: GO_0070567

ethanolaminephosphotransferase activity
IAO_0000115: Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.
has db xref: EC:2.7.8.1
has db xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN
has db xref: RHEA:14596
has exact synonym: CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity
has exact synonym: CDPethanolamine diglyceride phosphotransferase activity
has exact synonym: diacylglycerol ethanolaminephosphotransferase activity
has exact synonym: phosphorylethanolamine-glyceride transferase activity
has OBO namespace: molecular_function
has related synonym: EPT
id: GO:0004307
type: Class
subclass of: GO_0017169

exo-alpha-sialidase activity
IAO_0000115: Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
has db xref: EC:3.2.1.18
has db xref: MetaCyc:3.2.1.18-RXN
has db xref: Reactome:REACT_115699
has db xref: Reactome:REACT_115906
has db xref: Reactome:REACT_116118
has db xref: Reactome:REACT_6348
has exact synonym: N-acylneuraminate glycohydrolase activity
has exact synonym: acetylneuraminidase activity
has exact synonym: acetylneuraminyl hydrolase activity
has exact synonym: alpha-neuraminidase activity
has exact synonym: neuraminidase activity
has exact synonym: sialidase activity
has OBO namespace: molecular_function
id: GO:0004308
in subset: gosubset prok
type: Class
subclass of: GO_0016997

exopolyphosphatase activity
IAO_0000115: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.
has broad synonym: metaphosphatase activity
has db xref: EC:3.6.1.11
has db xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN
has exact synonym: Gra-Pase activity
has exact synonym: acid phosphoanhydride phosphohydrolase activity
has exact synonym: exopolypase activity
has exact synonym: polyphosphate phosphohydrolase activity
has OBO namespace: molecular_function
id: GO:0004309
in subset: gosubset prok
type: Class
subclass of: GO_0016462

farnesyl-diphosphate farnesyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
has db xref: EC:2.5.1.21
has db xref: MetaCyc:2.5.1.21-RXN
has db xref: Reactome:REACT_101662
has db xref: Reactome:REACT_105154
has db xref: Reactome:REACT_106161
has db xref: Reactome:REACT_107400
has db xref: Reactome:REACT_108729
has db xref: Reactome:REACT_108746
has db xref: Reactome:REACT_110869
has db xref: Reactome:REACT_112589
has db xref: Reactome:REACT_112901
has db xref: Reactome:REACT_29867
has db xref: Reactome:REACT_77262
has db xref: Reactome:REACT_79816
has db xref: Reactome:REACT_80102
has db xref: Reactome:REACT_80447
has db xref: Reactome:REACT_80862
has db xref: Reactome:REACT_86856
has db xref: Reactome:REACT_87065
has db xref: Reactome:REACT_89846
has db xref: Reactome:REACT_91748
has db xref: Reactome:REACT_93117
has db xref: Reactome:REACT_93181
has db xref: Reactome:REACT_93268
has db xref: Reactome:REACT_9504
has db xref: Reactome:REACT_9512
has db xref: Reactome:REACT_95255
has db xref: Reactome:REACT_96060
has db xref: Reactome:REACT_98548
has db xref: Reactome:REACT_99523
has exact synonym: farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity
has exact synonym: presqualene synthase activity
has exact synonym: presqualene-diphosphate synthase activity
has OBO namespace: molecular_function
id: GO:0004310
in subset: gosubset prok
type: Class
comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'.
subclass of: farnesyltranstransferase activity

farnesyltranstransferase activity
IAO_0000115: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
has broad synonym: farnesyltransferase activity
has db xref: EC:2.5.1.29
has db xref: KEGG:R02061
has db xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN
has db xref: RHEA:17656
has exact synonym: geranylgeranyl pyrophosphate synthase activity
has exact synonym: geranylgeranyl pyrophosphate synthetase activity
has exact synonym: geranylgeranyl-PP synthetase activity
has exact synonym: geranylgeranyl-diphosphate synthase activity
has exact synonym: trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity
has OBO namespace: molecular_function
id: GO:0004311
in subset: gosubset prok
type: Class
subclass of: GO_0004659

fatty acid synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
has db xref: EC:2.3.1.85
has db xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN
has db xref: Reactome:REACT_112198
has db xref: Reactome:REACT_113128
has db xref: Reactome:REACT_1497
has db xref: Reactome:REACT_28371
has db xref: Reactome:REACT_78047
has db xref: Reactome:REACT_81687
has db xref: Reactome:REACT_81811
has db xref: Reactome:REACT_83657
has db xref: Reactome:REACT_83733
has db xref: Reactome:REACT_91445
has db xref: Reactome:REACT_96308
has db xref: Reactome:REACT_97636
has exact synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
has exact synonym: fatty-acid synthase activity
has OBO namespace: molecular_function
id: GO:0004312
in subset: gosubset prok
type: Class
subclass of: GO_0016747

[acyl-carrier-protein] S-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].
has broad synonym: ACAT activity
has db xref: EC:2.3.1.38
has db xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN
has exact synonym: ACP S-acetyltransferase activity
has exact synonym: ACP acetyltransferase activity
has exact synonym: ACPacetyltransferase activity
has exact synonym: [acyl-carrier protein] S-acetyltransferase activity
has exact synonym: acetyl coenzyme A-acyl-carrier-protein transacylase activity
has exact synonym: acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity
has exact synonym: acyl-carrier-protein S-acetyltransferase activity
has exact synonym: acyl-carrier-protein acetyltransferase activity
has exact synonym: acyl-carrier-proteinacetyltransferase activity
has OBO namespace: molecular_function
id: GO:0004313
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016418

[acyl-carrier-protein] S-malonyltransferase activity
IAO_0000115: Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].
has broad synonym: malonyl transacylase activity
has broad synonym: malonyl transferase activity
has db xref: EC:2.3.1.39
has db xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN
has exact synonym: ACP S-malonyltransferase activity
has exact synonym: MCAT activity
has exact synonym: [acyl-carrier protein] S-malonyltransferase activity
has exact synonym: acyl carrier protein malonyltransferase activity
has exact synonym: acyl carrier proteinmalonyltransferase activity
has exact synonym: acyl-carrier-protein S-malonyltransferase activity
has exact synonym: malonyl coenzyme A-acyl carrier protein transacylase activity
has exact synonym: malonyl-CoA-acyl carrier protein transacylase activity
has exact synonym: malonyl-CoA:ACP transacylase activity
has exact synonym: malonyl-CoA:AcpM transacylase activity
has exact synonym: malonyl-CoA:acyl carrier protein transacylase activity
has exact synonym: malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity
has OBO namespace: molecular_function
has related synonym: FabD
has related synonym: MAT
id: GO:0004314
in subset: gosubset prok
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016419

3-oxoacyl-[acyl-carrier-protein] synthase activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].
has broad synonym: condensing enzyme activity
has broad synonym: fatty acid condensing enzyme activity
has db xref: EC:2.3.1.41
has db xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN
has exact synonym: 3-ketoacyl-acyl carrier protein synthase activity
has exact synonym: 3-oxoacyl-ACP synthase activity
has exact synonym: 3-oxoacyl-[acyl-carrier protein] synthase activity
has exact synonym: 3-oxoacyl-acyl-carrier-protein synthase activity
has exact synonym: acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)
has exact synonym: acyl-malonyl acyl carrier protein-condensing enzyme activity
has exact synonym: acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity
has exact synonym: beta-ketoacyl acyl carrier protein synthase activity
has exact synonym: beta-ketoacyl synthetase activity
has exact synonym: beta-ketoacyl-ACP synthase I activity
has exact synonym: beta-ketoacyl-ACP synthetase activity
has exact synonym: beta-ketoacyl-[acyl carrier protein] synthase activity
has exact synonym: beta-ketoacyl-acyl carrier protein synthase activity
has exact synonym: beta-ketoacyl-acyl carrier protein synthetase activity
has exact synonym: beta-ketoacylsynthase activity
has exact synonym: ketoacyl-ACP synthase activity
has narrow synonym: KAS I activity
has OBO namespace: molecular_function
has related synonym: 3-oxoacyl:ACP synthase I
has related synonym: FabB
has related synonym: FabF1
has related synonym: KASI
has related synonym: beta-ketoacyl-acyl-carrier-protein synthase I
id: GO:0004315
in subset: gosubset prok
type: Class
subclass of: fatty acid synthase activity

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.
has db xref: EC:1.1.1.100
has db xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN
has exact synonym: (3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity
has exact synonym: 3-ketoacyl acyl carrier protein reductase activity
has exact synonym: 3-oxoacyl-ACP reductase activity
has exact synonym: 3-oxoacyl-ACPreductase activity
has exact synonym: 3-oxoacyl-[acyl-carrier protein] reductase activity
has exact synonym: 3-oxoacyl-acyl-carrier-protein reductase activity
has exact synonym: NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity
has exact synonym: beta-ketoacyl acyl carrier protein (ACP) reductase activity
has exact synonym: beta-ketoacyl reductase activity
has exact synonym: beta-ketoacyl thioester reductase activity
has exact synonym: beta-ketoacyl-ACP reductase activity
has exact synonym: beta-ketoacyl-acyl carrier protein reductase activity
has exact synonym: beta-ketoacyl-acyl-carrier protein(ACP) reductase activity
has OBO namespace: molecular_function
id: GO:0004316
in subset: gosubset prok
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016616

3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
IAO_0000115: Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.
has db xref: EC:4.2.1.61
has db xref: KEGG:R04462
has db xref: MetaCyc:4.2.1.61-RXN
has exact synonym: (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity
has exact synonym: (3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)
has exact synonym: (3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity
has exact synonym: 3-hydroxypalmitoyl-ACP dehydratase activity
has exact synonym: 3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity
has exact synonym: 3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
has exact synonym: D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
has exact synonym: D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
has exact synonym: beta-hydroxypalmitoyl thioester dehydratase activity
has exact synonym: beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity
has exact synonym: beta-hydroxypalmityl-ACP dehydrase activity
has OBO namespace: molecular_function
id: GO:0004317
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0019171

enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+.
has db xref: EC:1.3.1.9
has db xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN
has exact synonym: NADH-enoyl acyl carrier protein reductase activity
has exact synonym: NADH-specific enoyl-ACP reductase activity
has exact synonym: acyl-acyl-carrier-protein:NAD+ oxidoreductase
has exact synonym: enoyl-ACP reductase (NADH) activity
has exact synonym: enoyl-[acyl-carrier protein] reductase (NADH) activity
has exact synonym: enoyl-acyl-carrier-protein reductase (NADH)
has OBO namespace: molecular_function
id: GO:0004318
in subset: gosubset prok
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016628

enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.
has db xref: EC:1.3.1.10
has db xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN
has exact synonym: NADPH 2-enoyl Co A reductase activity
has exact synonym: acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)
has exact synonym: enoyl acyl-carrier-protein reductase activity
has exact synonym: enoyl-ACP reductase (NADPH, B-specific) activity
has exact synonym: enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity
has exact synonym: enoyl-acyl-carrier-protein reductase (NADPH, B-specific)
has exact synonym: enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)
has exact synonym: reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)
has OBO namespace: molecular_function
id: GO:0004319
in subset: gosubset prok
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016628

oleoyl-[acyl-carrier-protein] hydrolase activity
IAO_0000115: Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate.
has broad synonym: oleoyl-acyl-carrier-protein hydrolase
has db xref: EC:3.1.2.14
has db xref: MetaCyc:3.1.2.14-RXN
has db xref: MetaCyc:PWY-5142
has exact synonym: oleoyl-ACP hydrolase activity
has exact synonym: oleoyl-ACP thioesterase activity
has exact synonym: oleoyl-[acyl-carrier protein] hydrolase activity
has exact synonym: oleoyl-acyl carrier protein thioesterase activity
has OBO namespace: molecular_function
id: GO:0004320
in subset: gosubset prok
type: Class
subclass of: GO_0016297

fatty-acyl-CoA synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
has db xref: EC:2.3.1.86
has db xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN
has exact synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
has exact synonym: fatty acyl CoA synthase activity
has narrow synonym: yeast fatty acid synthase activity
has OBO namespace: molecular_function
id: GO:0004321
type: Class
subclass of: GO_0016408

ferroxidase activity
IAO_0000115: Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
has db xref: EC:1.16.3.1
has db xref: MetaCyc:RXN0-1483
has db xref: RHEA:11151
has db xref: Reactome:REACT_115629
has db xref: Reactome:REACT_25098
has db xref: Reactome:REACT_25198
has exact synonym: Fe(II):oxygen oxidoreductase activity
has exact synonym: ferro:O2 oxidoreductase activity
has exact synonym: ferroxidase, iron II:oxygen oxidoreductase activity
has exact synonym: iron(II): oxygen oxidoreductase activity
has narrow synonym: ceruloplasmin activity
has narrow synonym: multicopper ferroxidase iron transport mediator activity
has OBO namespace: molecular_function
has related synonym: caeruloplasmin
has related synonym: ferroxidase I
id: GO:0004322
in subset: gosubset prok
type: Class
subclass of: GO_0016724

multicopper ferroxidase iron transport mediator activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
consider: GO:0004322
consider: GO:0005381
has OBO namespace: molecular_function
id: GO:0004323
type: Class
comment: This term was made obsolete because it represents a multifunctional gene product.
deprecated: true

ferredoxin-NADP+ reductase activity
IAO_0000115: Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.
has db xref: EC:1.18.1.2
has db xref: MetaCyc:1.18.1.2-RXN
has exact synonym: NADP:ferredoxin oxidoreductase activity
has exact synonym: NADPH:ferredoxin oxidoreductase activity
has exact synonym: TPNH-ferredoxin reductase activity
has exact synonym: ferredoxin-NADP oxidoreductase activity
has exact synonym: ferredoxin-NADP reductase activity
has exact synonym: ferredoxin-NADP-oxidoreductase activity
has exact synonym: ferredoxin-TPN reductase activity
has exact synonym: ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity
has exact synonym: ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity
has exact synonym: ferredoxin:NADP+ oxidoreductase activity
has exact synonym: reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity
has OBO namespace: molecular_function
id: GO:0004324
in subset: gosubset prok
type: Class
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'.
subclass of: GO_0016731

ferrochelatase activity
IAO_0000115: Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX.
has db xref: EC:4.99.1.1
has db xref: KEGG:R00310
has db xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN
has db xref: RHEA:22587
has db xref: Reactome:REACT_102151
has db xref: Reactome:REACT_103500
has db xref: Reactome:REACT_113497
has db xref: Reactome:REACT_115167
has db xref: Reactome:REACT_115628
has db xref: Reactome:REACT_31724
has db xref: Reactome:REACT_34447
has db xref: Reactome:REACT_52193
has db xref: Reactome:REACT_77614
has db xref: Reactome:REACT_78000
has db xref: Reactome:REACT_78120
has db xref: Reactome:REACT_80925
has db xref: Reactome:REACT_83976
has db xref: Reactome:REACT_87767
has db xref: Reactome:REACT_90534
has db xref: Reactome:REACT_92687
has db xref: Reactome:REACT_93298
has db xref: Reactome:REACT_9461
has db xref: Reactome:REACT_96094
has db xref: Reactome:REACT_96730
has db xref: Reactome:REACT_97060
has exact synonym: ferro-protoporphyrin chelatase activity
has exact synonym: heme synthase activity
has exact synonym: heme synthetase activity
has exact synonym: iron chelatase activity
has exact synonym: protoheme ferro-lyase (protoporphyrin-forming)
has exact synonym: protoheme ferro-lyase activity
has exact synonym: protoheme ferrolyase activity
has OBO namespace: molecular_function
id: GO:0004325
in subset: gosubset prok
type: Class
subclass of: GO_0016829

tetrahydrofolylpolyglutamate synthase activity
IAO_0000115: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
has db xref: EC:6.3.2.17
has db xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
has db xref: Reactome:REACT_101002
has db xref: Reactome:REACT_101642
has db xref: Reactome:REACT_102351
has db xref: Reactome:REACT_102476
has db xref: Reactome:REACT_103881
has db xref: Reactome:REACT_103964
has db xref: Reactome:REACT_104258
has db xref: Reactome:REACT_104550
has db xref: Reactome:REACT_104661
has db xref: Reactome:REACT_104755
has db xref: Reactome:REACT_105205
has db xref: Reactome:REACT_107192
has db xref: Reactome:REACT_108051
has db xref: Reactome:REACT_108617
has db xref: Reactome:REACT_109321
has db xref: Reactome:REACT_109341
has db xref: Reactome:REACT_109757
has db xref: Reactome:REACT_110084
has db xref: Reactome:REACT_11083
has db xref: Reactome:REACT_11098
has db xref: Reactome:REACT_11134
has db xref: Reactome:REACT_28245
has db xref: Reactome:REACT_28993
has db xref: Reactome:REACT_30882
has db xref: Reactome:REACT_31048
has db xref: Reactome:REACT_31179
has db xref: Reactome:REACT_31465
has db xref: Reactome:REACT_31897
has db xref: Reactome:REACT_32176
has db xref: Reactome:REACT_32353
has db xref: Reactome:REACT_32481
has db xref: Reactome:REACT_33340
has db xref: Reactome:REACT_34097
has db xref: Reactome:REACT_34214
has db xref: Reactome:REACT_34227
has db xref: Reactome:REACT_34370
has db xref: Reactome:REACT_34481
has db xref: Reactome:REACT_77255
has db xref: Reactome:REACT_78566
has db xref: Reactome:REACT_79142
has db xref: Reactome:REACT_79493
has db xref: Reactome:REACT_82730
has db xref: Reactome:REACT_83339
has db xref: Reactome:REACT_83909
has db xref: Reactome:REACT_84744
has db xref: Reactome:REACT_85520
has db xref: Reactome:REACT_85664
has db xref: Reactome:REACT_86615
has db xref: Reactome:REACT_87310
has db xref: Reactome:REACT_88455
has db xref: Reactome:REACT_88637
has db xref: Reactome:REACT_88916
has db xref: Reactome:REACT_90378
has db xref: Reactome:REACT_91152
has db xref: Reactome:REACT_92262
has db xref: Reactome:REACT_95920
has db xref: Reactome:REACT_97118
has db xref: Reactome:REACT_97580
has db xref: Reactome:REACT_97776
has db xref: Reactome:REACT_99456
has exact synonym: FPGS activity
has exact synonym: N(10)-formyltetrahydropteroyldiglutamate synthetase activity
has exact synonym: N10-formyltetrahydropteroyldiglutamate synthetase activity
has exact synonym: folate polyglutamate synthetase activity
has exact synonym: folylpoly(gamma-glutamate) synthase activity
has exact synonym: folylpoly-gamma-glutamate synthase activity
has exact synonym: folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
has exact synonym: folylpolyglutamate synthase activity
has exact synonym: folylpolyglutamate synthetase activity
has exact synonym: folylpolyglutamyl synthetase activity
has exact synonym: formyltetrahydropteroyldiglutamate synthetase activity
has exact synonym: tetrahydrofolate synthase activity
has exact synonym: tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
has exact synonym: tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
has exact synonym: tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
has OBO namespace: molecular_function
id: GO:0004326

formaldehyde dehydrogenase (glutathione) activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+.
consider: GO:0051903
consider: GO:0051907
has OBO namespace: molecular_function
id: GO:0004327
in subset: gosubset prok
type: Class
comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries.
deprecated: true

formamidase activity
IAO_0000115: Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+).
has alternative id: GO:0034566
has db xref: EC:3.5.1.49
has db xref: KEGG:R00524
has db xref: MetaCyc:FORMAMIDASE-RXN
has db xref: RHEA:21951
has db xref: UM-BBD_reactionID:r0873
has exact synonym: formamide amidohydrolase activity
has exact synonym: formamide hydrolase activity
has OBO namespace: molecular_function
id: GO:0004328
in subset: gosubset prok
type: Class
subclass of: GO_0016811

formate-tetrahydrofolate ligase activity
IAO_0000115: Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
has db xref: EC:6.3.4.3
has db xref: MetaCyc:FORMATETHFLIG-RXN
has db xref: RHEA:20224
has db xref: Reactome:REACT_101414
has db xref: Reactome:REACT_104328
has db xref: Reactome:REACT_109830
has db xref: Reactome:REACT_11109
has db xref: Reactome:REACT_112991
has db xref: Reactome:REACT_34410
has db xref: Reactome:REACT_78582
has db xref: Reactome:REACT_84185
has db xref: Reactome:REACT_87843
has db xref: Reactome:REACT_89407
has db xref: Reactome:REACT_89474
has db xref: Reactome:REACT_91046
has db xref: Reactome:REACT_97400
has db xref: Reactome:REACT_98873
has exact synonym: 10-formyl-THF synthetase activity
has exact synonym: 10-formyltetrahydrofolate synthetase activity
has exact synonym: formate:tetrahydrofolate ligase (ADP-forming)
has exact synonym: formyltetrahydrofolate synthetase activity
has exact synonym: tetrahydrofolate formylase activity
has exact synonym: tetrahydrofolic formylase activity
has OBO namespace: molecular_function
id: GO:0004329
in subset: gosubset prok
type: Class
subclass of: GO_0016879

fructose-2,6-bisphosphate 2-phosphatase activity
IAO_0000115: Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
has alternative id: GO:0004330
has db xref: EC:3.1.3.46
has db xref: MetaCyc:3.1.3.46-RXN
has db xref: RHEA:17292
has db xref: Reactome:REACT_102107
has db xref: Reactome:REACT_103429
has db xref: Reactome:REACT_1084
has db xref: Reactome:REACT_108509
has db xref: Reactome:REACT_109004
has db xref: Reactome:REACT_113676
has db xref: Reactome:REACT_116155
has db xref: Reactome:REACT_28511
has db xref: Reactome:REACT_30510
has db xref: Reactome:REACT_31865
has db xref: Reactome:REACT_32951
has db xref: Reactome:REACT_33560
has db xref: Reactome:REACT_34794
has db xref: Reactome:REACT_61251
has db xref: Reactome:REACT_80450
has db xref: Reactome:REACT_82116
has db xref: Reactome:REACT_88106
has db xref: Reactome:REACT_91852
has exact synonym: D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
has exact synonym: beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
has exact synonym: fructose-2,6-bisphosphatase activity
has OBO namespace: molecular_function
id: GO:0004331
in subset: gosubset prok
type: Class
subclass of: GO_0050308

fructose-bisphosphate aldolase activity
IAO_0000115: Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
has broad synonym: aldolase activity
has db xref: EC:4.1.2.13
has db xref: MetaCyc:F16ALDOLASE-RXN
has db xref: RHEA:14732
has db xref: Reactome:REACT_100157
has db xref: Reactome:REACT_103150
has db xref: Reactome:REACT_103723
has db xref: Reactome:REACT_104551
has db xref: Reactome:REACT_105453
has db xref: Reactome:REACT_106543
has db xref: Reactome:REACT_109373
has db xref: Reactome:REACT_109674
has db xref: Reactome:REACT_115951
has db xref: Reactome:REACT_116035
has db xref: Reactome:REACT_1602
has db xref: Reactome:REACT_2013
has db xref: Reactome:REACT_235
has db xref: Reactome:REACT_28350
has db xref: Reactome:REACT_29075
has db xref: Reactome:REACT_29122
has db xref: Reactome:REACT_29507
has db xref: Reactome:REACT_31345
has db xref: Reactome:REACT_33880
has db xref: Reactome:REACT_34216
has db xref: Reactome:REACT_34422
has db xref: Reactome:REACT_34557
has db xref: Reactome:REACT_34732
has db xref: Reactome:REACT_46393
has db xref: Reactome:REACT_61775
has db xref: Reactome:REACT_77422
has db xref: Reactome:REACT_79711
has db xref: Reactome:REACT_79785
has db xref: Reactome:REACT_80109
has db xref: Reactome:REACT_80843
has db xref: Reactome:REACT_82777
has db xref: Reactome:REACT_83035
has db xref: Reactome:REACT_85023
has db xref: Reactome:REACT_86042
has db xref: Reactome:REACT_86101
has db xref: Reactome:REACT_87126
has db xref: Reactome:REACT_88404
has db xref: Reactome:REACT_88447
has db xref: Reactome:REACT_90018
has db xref: Reactome:REACT_90029
has db xref: Reactome:REACT_91667
has db xref: Reactome:REACT_91845
has db xref: Reactome:REACT_92822
has db xref: Reactome:REACT_94406
has db xref: Reactome:REACT_94423
has db xref: Reactome:REACT_95451
has db xref: Reactome:REACT_97153
has db xref: Reactome:REACT_97915
has db xref: Reactome:REACT_98113
has db xref: Reactome:REACT_99298
has exact synonym: 1,6-diphosphofructose aldolase activity
has exact synonym: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
has exact synonym: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity
has exact synonym: diphosphofructose aldolase activity
has exact synonym: fructoaldolase activity
has exact synonym: fructose 1,6-diphosphate aldolase activity
has exact synonym: fructose 1-monophosphate aldolase activity
has exact synonym: fructose 1-phosphate aldolase activity
has exact synonym: fructose diphosphate aldolase activity
has exact synonym: fructose-1,6-bisphosphate triosephosphate-lyase activity
has exact synonym: ketose 1-phosphate aldolase activity
has exact synonym: phosphofructoaldolase activity
has exact synonym: zymohexase activity
has OBO namespace: molecular_function
has related synonym: SMALDO
id: GO:0004332
in subset: gosubset prok
type: Class
subclass of: GO_0016832

fumarate hydratase activity
IAO_0000115: Catalysis of the reaction: (S)-malate = fumarate + H(2)O.
has db xref: EC:4.2.1.2
has db xref: KEGG:R01082
has db xref: MetaCyc:FUMHYDR-RXN
has db xref: RHEA:12463
has db xref: Reactome:REACT_100573
has db xref: Reactome:REACT_102283
has db xref: Reactome:REACT_102637
has db xref: Reactome:REACT_103835
has db xref: Reactome:REACT_104675
has db xref: Reactome:REACT_109085
has db xref: Reactome:REACT_115295
has db xref: Reactome:REACT_115714
has db xref: Reactome:REACT_115901
has db xref: Reactome:REACT_1656
has db xref: Reactome:REACT_21360
has db xref: Reactome:REACT_33209
has db xref: Reactome:REACT_77316
has db xref: Reactome:REACT_82795
has db xref: Reactome:REACT_82946
has db xref: Reactome:REACT_90400
has db xref: Reactome:REACT_91925
has db xref: Reactome:REACT_93250
has db xref: Reactome:REACT_93953
has db xref: Reactome:REACT_94620
has db xref: Reactome:REACT_96178
has exact synonym: (S)-malate hydro-lyase (fumarate-forming)
has exact synonym: (S)-malate hydro-lyase activity
has exact synonym: L-malate hydro-lyase activity
has exact synonym: fumarase activity
has OBO namespace: molecular_function
id: GO:0004333
in subset: gosubset prok
type: Class
subclass of: GO_0016836

fumarylacetoacetase activity
IAO_0000115: Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
has db xref: EC:3.7.1.2
has db xref: KEGG:R01364
has db xref: MetaCyc:FUMARYLACETOACETASE-RXN
has db xref: RHEA:10247
has db xref: Reactome:REACT_101871
has db xref: Reactome:REACT_102851
has db xref: Reactome:REACT_105315
has db xref: Reactome:REACT_109988
has db xref: Reactome:REACT_1297
has db xref: Reactome:REACT_31058
has db xref: Reactome:REACT_31994
has db xref: Reactome:REACT_77401
has db xref: Reactome:REACT_80968
has db xref: Reactome:REACT_87154
has db xref: Reactome:REACT_87657
has db xref: Reactome:REACT_90501
has db xref: Reactome:REACT_94208
has db xref: Reactome:REACT_96671
has db xref: Reactome:REACT_97148
has db xref: UM-BBD_reactionID:r0107
has exact synonym: 4-fumarylacetoacetate fumarylhydrolase activity
has exact synonym: beta-diketonase activity
has exact synonym: fumarylacetoacetate hydrolase activity
has OBO namespace: molecular_function
id: GO:0004334
in subset: gosubset prok
type: Class
subclass of: GO_0016823

galactokinase activity
IAO_0000115: Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).
has db xref: EC:2.7.1.6
has db xref: KEGG:R01092
has db xref: MetaCyc:GALACTOKIN-RXN
has db xref: RHEA:13556
has db xref: Reactome:REACT_101502
has db xref: Reactome:REACT_104899
has db xref: Reactome:REACT_106662
has db xref: Reactome:REACT_107666
has db xref: Reactome:REACT_113809
has db xref: Reactome:REACT_1246
has db xref: Reactome:REACT_32797
has db xref: Reactome:REACT_89577
has db xref: Reactome:REACT_91072
has db xref: Reactome:REACT_91251
has db xref: Reactome:REACT_94404
has db xref: Reactome:REACT_99486
has exact synonym: ATP:D-galactose 1-phosphotransferase activity
has exact synonym: ATP:D-galactose-1-phosphotransferase activity
has exact synonym: galactokinase (phosphorylating)
has OBO namespace: molecular_function
id: GO:0004335
in subset: gosubset prok
type: Class
subclass of: GO_0016773
subclass of: GO_0019200

galactosylceramidase activity
IAO_0000115: Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.
has db xref: EC:3.2.1.46
has db xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN
has db xref: RHEA:14300
has db xref: Reactome:REACT_115737
has exact synonym: D-galactosyl-N-acylsphingosine galactohydrolase activity
has exact synonym: beta-galactocerebrosidase activity
has exact synonym: beta-galactosylceramidase activity
has exact synonym: ceramide galactosidase activity
has exact synonym: cerebroside beta-galactosidase activity
has exact synonym: cerebroside galactosidase activity
has exact synonym: galactocerebrosidase activity
has exact synonym: galactocerebroside beta-galactosidase activity
has exact synonym: galactocerebroside galactosidase activity
has exact synonym: galactocerebroside-beta-D-galactosidase activity
has exact synonym: galactosylceramide beta-galactosidase activity
has exact synonym: galactosylcerebrosidase activity
has exact synonym: galcerase activity
has exact synonym: lactosylceramidase activity
has OBO namespace: molecular_function
has related synonym: galactosylceramidase I
has related synonym: lactosylceramidase I
id: GO:0004336
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

geranyltranstransferase activity
IAO_0000115: Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.
has db xref: EC:2.5.1.10
has db xref: KEGG:R02003
has db xref: MetaCyc:FPPSYN-RXN
has db xref: RHEA:19364
has db xref: Reactome:REACT_106226
has db xref: Reactome:REACT_106273
has db xref: Reactome:REACT_106937
has db xref: Reactome:REACT_108353
has db xref: Reactome:REACT_110008
has db xref: Reactome:REACT_31479
has db xref: Reactome:REACT_32096
has db xref: Reactome:REACT_32332
has db xref: Reactome:REACT_80399
has db xref: Reactome:REACT_80850
has db xref: Reactome:REACT_82492
has db xref: Reactome:REACT_86369
has db xref: Reactome:REACT_87629
has db xref: Reactome:REACT_9451
has db xref: Reactome:REACT_95036
has db xref: Reactome:REACT_95560
has db xref: Reactome:REACT_96641
has db xref: Reactome:REACT_99168
has exact synonym: FPP synthetase activity
has exact synonym: farnesyl diphosphate synthetase activity
has exact synonym: farnesyl pyrophosphate synthetase activity
has exact synonym: farnesyl-diphosphate synthase activity
has exact synonym: farnesylpyrophosphate synthetase activity
has exact synonym: geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity
has exact synonym: geranyltransferase activity
has OBO namespace: molecular_function
has related synonym: geranyl transferase I
id: GO:0004337
in subset: gosubset prok
type: Class
comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
subclass of: GO_0004659

glucan exo-1,3-beta-glucosidase activity
IAO_0000115: Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.
has broad synonym: 1,3-beta-glucan glucohydrolase activity
has broad synonym: glucan 1,3-beta-glucosidase activity
has db xref: EC:3.2.1.58
has db xref: MetaCyc:3.2.1.58-RXN
has exact synonym: beta-1,3-glucan exo-hydrolase activity
has exact synonym: exo (1->3)-beta-glucanase activity
has exact synonym: exo-1,3-beta-D-glucanase activity
has exact synonym: exo-1,3-beta-glucanase activity
has exact synonym: exo-1,3-beta-glucosidase activity
has exact synonym: exo-beta-(1->3)-D-glucanase activity
has exact synonym: exo-beta-(1->3)-glucanohydrolase activity
has exact synonym: exo-beta-1,3-D-glucanase activity
has exact synonym: exo-beta-1,3-glucanase activity
has OBO namespace: molecular_function
id: GO:0004338
type: Class
subclass of: GO_0008422

glucan 1,4-alpha-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.
has broad synonym: lysosomal alpha-glucosidase activity
has db xref: EC:3.2.1.3
has db xref: MetaCyc:3.2.1.3-RXN
has exact synonym: 1,4-alpha-D-glucan glucohydrolase activity
has exact synonym: amyloglucosidase activity
has exact synonym: exo-1,4-alpha-glucosidase activity
has exact synonym: gamma-1,4-glucan glucohydrolase activity
has exact synonym: gamma-amylase activity
has exact synonym: glucoamylase activity
has exact synonym: glucose amylase activity
has OBO namespace: molecular_function
id: GO:0004339
in subset: gosubset prok
type: Class
comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0004558', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0004558 alpha-D-glucose is released.
subclass of: GO_0015926

glucokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
has db xref: EC:2.7.1.2
has db xref: MetaCyc:GLUCOKIN-RXN
has db xref: RHEA:17828
has db xref: Reactome:REACT_109618
has db xref: Reactome:REACT_115950
has db xref: Reactome:REACT_1827
has db xref: Reactome:REACT_28331
has db xref: Reactome:REACT_28504
has db xref: Reactome:REACT_31619
has db xref: Reactome:REACT_33904
has db xref: Reactome:REACT_34118
has db xref: Reactome:REACT_80323
has db xref: Reactome:REACT_81488
has db xref: Reactome:REACT_82793
has db xref: Reactome:REACT_84021
has db xref: Reactome:REACT_85927
has db xref: Reactome:REACT_88172
has db xref: Reactome:REACT_90073
has db xref: Reactome:REACT_92495
has db xref: Reactome:REACT_96462
has exact synonym: ATP:D-glucose 6-phosphotransferase activity
has exact synonym: glucokinase (phosphorylating)
has exact synonym: glucose kinase activity
has OBO namespace: molecular_function
id: GO:0004340
in subset: gosubset prok
type: Class
subclass of: hexokinase activity

gluconolactonase activity
IAO_0000115: Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
has broad synonym: lactonase activity
has db xref: EC:3.1.1.17
has db xref: MetaCyc:GLUCONOLACT-RXN
has db xref: RHEA:10443
has exact synonym: D-glucono-1,5-lactone lactonohydrolase activity
has exact synonym: aldonolactonase activity
has exact synonym: glucono-delta-lactonase activity
has exact synonym: gulonolactonase activity
has OBO namespace: molecular_function
id: GO:0004341
in subset: gosubset prok
type: Class
subclass of: GO_0052689

glucosamine-6-phosphate deaminase activity
IAO_0000115: Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+).
has broad synonym: glucosaminephosphate isomerase
has db xref: EC:3.5.99.6
has db xref: KEGG:R00765
has db xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN
has db xref: RHEA:12175
has exact synonym: 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
has exact synonym: GlcN6P deaminase activity
has exact synonym: aminodeoxyglucosephosphate isomerase activity
has exact synonym: glucosamine phosphate deaminase activity
has exact synonym: glucosamine-6-phosphate isomerase activity
has exact synonym: phosphoglucosamine isomerase activity
has exact synonym: phosphoglucosaminisomerase activity
has OBO namespace: molecular_function
id: GO:0004342
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:5.3.1.10.
subclass of: GO_0016861
subclass of: GO_0019239

glucosamine 6-phosphate N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+).
has db xref: EC:2.3.1.4
has db xref: KEGG:R02058
has db xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN
has db xref: RHEA:10295
has db xref: Reactome:REACT_22233
has exact synonym: D-glucosamine-6-P N-acetyltransferase activity
has exact synonym: N-acetylglucosamine-6-phosphate synthase activity
has exact synonym: acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity
has exact synonym: aminodeoxyglucosephosphate acetyltransferase activity
has exact synonym: glucosamine 6-phosphate acetylase activity
has exact synonym: glucosamine-6-phosphate acetylase activity
has exact synonym: glucosamine-phosphate N-acetyltransferase activity
has exact synonym: phosphoglucosamine N-acetylase activity
has exact synonym: phosphoglucosamine acetylase activity
has exact synonym: phosphoglucosamine transacetylase activity
has OBO namespace: molecular_function
id: GO:0004343
in subset: gosubset prok
type: Class
subclass of: GO_0008080

glucose dehydrogenase activity
IAO_0000115: Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor.
has alternative id: GO:0008708
has db xref: EC:1.1.99.10
has db xref: KEGG:R00305
has db xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN
has db xref: RHEA:24543
has exact synonym: D-glucose:(acceptor) 1-oxidoreductase
has exact synonym: D-glucose:acceptor 1-oxidoreductase
has exact synonym: glucose dehydrogenase (acceptor) activity
has exact synonym: glucose dehydrogenase (decarboxylating)
has narrow synonym: glucose dehydrogenase (Aspergillus) activity
has OBO namespace: molecular_function
id: GO:0004344
type: Class
subclass of: GO_0016614

glucose-6-phosphate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
has db xref: EC:1.1.1.49
has db xref: MetaCyc:GLU6PDEHYDROG-RXN
has db xref: RHEA:15844
has db xref: Reactome:REACT_102558
has db xref: Reactome:REACT_104275
has db xref: Reactome:REACT_112685
has db xref: Reactome:REACT_114196
has db xref: Reactome:REACT_114740
has db xref: Reactome:REACT_1868
has db xref: Reactome:REACT_28663
has db xref: Reactome:REACT_29982
has db xref: Reactome:REACT_31126
has db xref: Reactome:REACT_33226
has db xref: Reactome:REACT_33546
has db xref: Reactome:REACT_34758
has db xref: Reactome:REACT_80140
has db xref: Reactome:REACT_83159
has db xref: Reactome:REACT_84676
has db xref: Reactome:REACT_87680
has db xref: Reactome:REACT_89131
has db xref: Reactome:REACT_90405
has exact synonym: 6-phosphoglucose dehydrogenase activity
has exact synonym: D-glucose 6-phosphate dehydrogenase activity
has exact synonym: D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity
has exact synonym: G6PD activity
has exact synonym: G6PDH
has exact synonym: NADP-dependent glucose 6-phosphate dehydrogenase activity
has exact synonym: NADP-glucose-6-phosphate dehydrogenase activity
has exact synonym: glucose 6-phosphate dehydrogenase (NADP) activity
has exact synonym: glucose-6-phosphate 1-dehydrogenase activity
has OBO namespace: molecular_function
has related synonym: 6-phosphoglucose dehydrogenas
has related synonym: Entner-doudoroff enzyme
has related synonym: GDH
has related synonym: Zwischenferment
has related synonym: zwischenferment
id: GO:0004345
in subset: gosubset prok
type: Class
subclass of: GO_0016616

glucose-6-phosphatase activity
IAO_0000115: Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.
has db xref: EC:3.1.3.9
has db xref: KEGG:R00303
has db xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN
has db xref: RHEA:16692
has db xref: Reactome:REACT_101074
has db xref: Reactome:REACT_101088
has db xref: Reactome:REACT_115845
has db xref: Reactome:REACT_1682
has db xref: Reactome:REACT_30178
has db xref: Reactome:REACT_33577
has db xref: Reactome:REACT_85407
has db xref: Reactome:REACT_85737
has db xref: Reactome:REACT_89941
has db xref: Reactome:REACT_94617
has db xref: Reactome:REACT_94861
has db xref: Reactome:REACT_97985
has exact synonym: D-glucose-6-phosphate phosphohydrolase activity
has exact synonym: glucose 6-phosphate phosphatase activity
has OBO namespace: molecular_function
id: GO:0004346
in subset: gosubset prok
type: Class
subclass of: GO_0050309

glucose-6-phosphate isomerase activity
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.
has broad synonym: hexose monophosphate isomerase activity
has broad synonym: hexosephosphate isomerase activity
has broad synonym: phosphohexoisomerase activity
has broad synonym: phosphohexomutase activity
has broad synonym: phosphohexose isomerase activity
has broad synonym: phosphosaccharomutase activity
has db xref: EC:5.3.1.9
has db xref: MetaCyc:PGLUCISOM-RXN
has db xref: RHEA:11819
has db xref: Reactome:REACT_100001
has db xref: Reactome:REACT_100164
has db xref: Reactome:REACT_100236
has db xref: Reactome:REACT_100583
has db xref: Reactome:REACT_101103
has db xref: Reactome:REACT_102104
has db xref: Reactome:REACT_102404
has db xref: Reactome:REACT_103273
has db xref: Reactome:REACT_105129
has db xref: Reactome:REACT_105396
has db xref: Reactome:REACT_106541
has db xref: Reactome:REACT_107983
has db xref: Reactome:REACT_109795
has db xref: Reactome:REACT_109950
has db xref: Reactome:REACT_110852
has db xref: Reactome:REACT_113483
has db xref: Reactome:REACT_115143
has db xref: Reactome:REACT_115648
has db xref: Reactome:REACT_115859
has db xref: Reactome:REACT_1255
has db xref: Reactome:REACT_1690
has db xref: Reactome:REACT_29005
has db xref: Reactome:REACT_30934
has db xref: Reactome:REACT_32507
has db xref: Reactome:REACT_33390
has db xref: Reactome:REACT_78538
has db xref: Reactome:REACT_78791
has db xref: Reactome:REACT_79357
has db xref: Reactome:REACT_79978
has db xref: Reactome:REACT_82677
has db xref: Reactome:REACT_85092
has db xref: Reactome:REACT_85936
has db xref: Reactome:REACT_86098
has db xref: Reactome:REACT_87510
has db xref: Reactome:REACT_90932
has db xref: Reactome:REACT_94008
has db xref: Reactome:REACT_96038
has db xref: Reactome:REACT_97996
has db xref: Reactome:REACT_98117
has db xref: Reactome:REACT_98949
has db xref: Reactome:REACT_99481
has db xref: Reactome:REACT_99765
has exact synonym: D-glucose-6-phosphate aldose-ketose-isomerase activity
has exact synonym: D-glucose-6-phosphate ketol-isomerase activity
has exact synonym: glucose phosphate isomerase activity
has exact synonym: hexose phosphate isomerase activity
has exact synonym: phosphoglucoisomerase activity
has exact synonym: phosphoglucose isomerase activity
has OBO namespace: molecular_function
has related synonym: oxoisomerase activity
id: GO:0004347
in subset: gosubset prok
type: Class
subclass of: GO_0016861

glucosylceramidase activity
IAO_0000115: Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
has db xref: EC:3.2.1.45
has db xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN
has db xref: RHEA:13272
has db xref: Reactome:REACT_115656
has db xref: Reactome:REACT_115663
has db xref: Reactome:REACT_115724
has exact synonym: D-glucosyl-N-acylsphingosine glucohydrolase activity
has exact synonym: GlcCer-beta-glucosidase activity
has exact synonym: acid beta-glucosidase activity
has exact synonym: beta-D-glucocerebrosidase activity
has exact synonym: beta-glucocerebrosidase activity
has exact synonym: beta-glucosylceramidase activity
has exact synonym: ceramide glucosidase activity
has exact synonym: glucocerebrosidase activity
has exact synonym: glucosphingosine glucosylhydrolase activity
has exact synonym: glucosylcerebrosidase activity
has exact synonym: glucosylsphingosine beta-D-glucosidase activity
has exact synonym: glucosylsphingosine beta-glucosidase activity
has exact synonym: psychosine hydrolase activity
has OBO namespace: molecular_function
id: GO:0004348
in subset: gosubset prok
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

glutamate 5-kinase activity
IAO_0000115: Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
has db xref: EC:2.7.2.11
has db xref: KEGG:R00239
has db xref: MetaCyc:GLUTKIN-RXN
has db xref: RHEA:14880
has exact synonym: ATP-L-glutamate 5-phosphotransferase activity
has exact synonym: ATP:L-glutamate 5-phosphotransferase activity
has exact synonym: ATP:gamma-L-glutamate phosphotransferase activity
has exact synonym: gamma-glutamate kinase activity
has exact synonym: gamma-glutamyl kinase activity
has exact synonym: glutamate kinase activity
has OBO namespace: molecular_function
id: GO:0004349
in subset: gosubset prok
type: Class
subclass of: GO_0016774
subclass of: GO_0019202

glutamate-5-semialdehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
has alternative id: GO:0001513
has db xref: EC:1.2.1.41
has db xref: KEGG:R03313
has db xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN
has db xref: RHEA:19544
has exact synonym: L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
has exact synonym: beta-glutamylphosphate reductase activity
has exact synonym: gamma-glutamyl phosphate reductase activity
has exact synonym: gamma-glutamylphosphate reductase activity
has exact synonym: glutamate semialdehyde dehydrogenase activity
has exact synonym: glutamate-gamma-semialdehyde dehydrogenase activity
has exact synonym: glutamate-phosphate reductase activity
has exact synonym: glutamyl-gamma-semialdehyde dehydrogenase activity
has exact synonym: glutamylphosphate reductase activity
has OBO namespace: molecular_function
id: GO:0004350
in subset: gosubset prok
type: Class
subclass of: GO_0016620

glutamate decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
has broad synonym: aspartic alpha-decarboxylase
has db xref: EC:4.1.1.15
has db xref: MetaCyc:GLUTDECARBOX-RXN
has db xref: RHEA:17788
has db xref: Reactome:REACT_23866
has db xref: Reactome:REACT_23937
has exact synonym: L-aspartate-alpha-decarboxylase activity
has exact synonym: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
has exact synonym: L-glutamate 1-carboxy-lyase activity
has exact synonym: L-glutamate alpha-decarboxylase activity
has exact synonym: L-glutamic acid decarboxylase activity
has exact synonym: L-glutamic decarboxylase activity
has exact synonym: cysteic acid decarboxylase activity
has exact synonym: gamma-glutamate decarboxylase activity
has OBO namespace: molecular_function
id: GO:0004351
in subset: gosubset prok
type: Class
subclass of: GO_0016831

glutamate dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
has broad synonym: L-glutamate dehydrogenase
has broad synonym: glutamic acid dehydrogenase
has broad synonym: glutamic dehydrogenase activity
has db xref: EC:1.4.1.2
has db xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN
has db xref: RHEA:15136
has exact synonym: L-glutamate:NAD+ oxidoreductase (deaminating)
has exact synonym: NAD-dependent glutamate dehydrogenase activity
has exact synonym: NAD-dependent glutamic dehydrogenase activity
has exact synonym: NAD-glutamate dehydrogenase activity
has exact synonym: NAD-linked glutamate dehydrogenase activity
has exact synonym: NAD-linked glutamic dehydrogenase activity
has exact synonym: NAD-specific glutamate dehydrogenase activity
has exact synonym: NAD-specific glutamic dehydrogenase activity
has exact synonym: NAD:glutamate oxidoreductase activity
has exact synonym: NADH-linked glutamate dehydrogenase activity
has exact synonym: glutamate dehydrogenase (NAD)
has exact synonym: glutamate oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004352
in subset: gosubset prok
type: Class
subclass of: GO_0016639

glutamate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
has broad synonym: glutamic dehydrogenase activity
has db xref: EC:1.4.1.3
has db xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
has db xref: MetaCyc:GLUTAMATE-SYN2-PWY
has db xref: Reactome:REACT_100655
has db xref: Reactome:REACT_100656
has db xref: Reactome:REACT_104090
has db xref: Reactome:REACT_105114
has db xref: Reactome:REACT_106901
has db xref: Reactome:REACT_109912
has db xref: Reactome:REACT_112437
has db xref: Reactome:REACT_112733
has db xref: Reactome:REACT_113249
has db xref: Reactome:REACT_114470
has db xref: Reactome:REACT_1896
has db xref: Reactome:REACT_28386
has db xref: Reactome:REACT_710
has db xref: Reactome:REACT_78365
has db xref: Reactome:REACT_82868
has db xref: Reactome:REACT_83965
has db xref: Reactome:REACT_90113
has db xref: Reactome:REACT_93428
has db xref: Reactome:REACT_94386
has db xref: Reactome:REACT_95081
has db xref: Reactome:REACT_95259
has db xref: Reactome:REACT_96021
has exact synonym: L-glutamate:NAD(P)+ oxidoreductase (deaminating)
has OBO namespace: molecular_function
has related synonym: glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
has related synonym: glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
id: GO:0004353
in subset: gosubset prok
type: Class
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subclass of: GO_0016639

glutamate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
has broad synonym: L-glutamate dehydrogenase
has broad synonym: glutamic acid dehydrogenase
has broad synonym: glutamic dehydrogenase activity
has db xref: EC:1.4.1.4
has db xref: MetaCyc:GLUTDEHYD-RXN
has db xref: MetaCyc:GLUTSYNIII-PWY
has db xref: RHEA:11615
has exact synonym: L-glutamate:NADP+ oxidoreductase (deaminating)
has exact synonym: L-glutamic acid dehydrogenase activity
has exact synonym: NAD(P)-glutamate dehydrogenase activity
has exact synonym: NAD(P)H-dependent glutamate dehydrogenase activity
has exact synonym: dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
has OBO namespace: molecular_function
id: GO:0004354
in subset: gosubset prok
type: Class
subclass of: GO_0016639

glutamate synthase (NADPH) activity
IAO_0000115: Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.
has broad synonym: L-glutamate synthase activity
has broad synonym: L-glutamate synthetase activity
has db xref: EC:1.4.1.13
has db xref: KEGG:R00114
has db xref: MetaCyc:GLUGLNSYN-PWY
has db xref: MetaCyc:GLUTAMATESYN-RXN
has db xref: MetaCyc:GLUTSYN-PWY
has db xref: RHEA:11615
has db xref: RHEA:15504
has db xref: RHEA:15892
has exact synonym: GOGAT activity
has exact synonym: L-glutamate:NADP+ oxidoreductase (transaminating)
has exact synonym: L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity
has exact synonym: NADPH-dependent glutamate synthase activity
has exact synonym: NADPH-glutamate synthase activity
has exact synonym: NADPH-linked glutamate synthase
has exact synonym: glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity
has exact synonym: glutamate synthetase (NADP) activity
has exact synonym: glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity
has exact synonym: glutamine-ketoglutaric aminotransferase activity
has OBO namespace: molecular_function
id: GO:0004355
in subset: gosubset prok
type: Class
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subclass of: GO_0045181

glutamate-ammonia ligase activity
IAO_0000115: Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate.
has db xref: EC:6.3.1.2
has db xref: KEGG:R00253
has db xref: MetaCyc:GLUTAMINESYN-RXN
has db xref: RHEA:16172
has db xref: Reactome:REACT_104006
has db xref: Reactome:REACT_104940
has db xref: Reactome:REACT_110265
has db xref: Reactome:REACT_112105
has db xref: Reactome:REACT_115035
has db xref: Reactome:REACT_1171
has db xref: Reactome:REACT_28913
has db xref: Reactome:REACT_33705
has db xref: Reactome:REACT_34384
has db xref: Reactome:REACT_39662
has db xref: Reactome:REACT_77424
has db xref: Reactome:REACT_77661
has db xref: Reactome:REACT_86685
has db xref: Reactome:REACT_90402
has db xref: Reactome:REACT_90408
has db xref: Reactome:REACT_92620
has exact synonym: L-glutamate:ammonia ligase (ADP-forming)
has exact synonym: L-glutamine synthetase activity
has exact synonym: glutamine synthetase activity
has exact synonym: glutamylhydroxamic synthetase activity
has OBO namespace: molecular_function
id: GO:0004356
in subset: gosubset prok
type: Class
subclass of: GO_0016211

glutamate-cysteine ligase activity
IAO_0000115: Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
has db xref: EC:6.3.2.2
has db xref: KEGG:R00894
has db xref: MetaCyc:GLUTCYSLIG-RXN
has db xref: RHEA:13288
has db xref: Reactome:REACT_28974
has db xref: Reactome:REACT_29140
has db xref: Reactome:REACT_30350
has db xref: Reactome:REACT_32418
has db xref: Reactome:REACT_6970
has db xref: Reactome:REACT_79569
has db xref: Reactome:REACT_82470
has db xref: Reactome:REACT_88007
has db xref: Reactome:REACT_90345
has db xref: Reactome:REACT_91026
has db xref: Reactome:REACT_96699
has db xref: Reactome:REACT_99078
has exact synonym: L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
has exact synonym: gamma-glutamyl-L-cysteine synthetase activity
has exact synonym: gamma-glutamylcysteine synthetase activity
has exact synonym: gamma-glutamylcysteinyl synthetase activity
has OBO namespace: molecular_function
id: GO:0004357
in subset: gosubset prok
type: Class
subclass of: GO_0016881

glutamate N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.
has broad synonym: N-acetyl-L-glutamate synthetase activity
has broad synonym: N-acetylglutamate synthase activity
has broad synonym: N-acetylglutamate synthetase activity
has broad synonym: acetylornithinase activity
has db xref: EC:2.3.1.35
has db xref: KEGG:R02282
has db xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN
has db xref: RHEA:15352
has exact synonym: 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has exact synonym: N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has exact synonym: acetylglutamate synthetase activity
has exact synonym: acetylglutamate-acetylornithine transacetylase activity
has exact synonym: acetylglutamic synthetase activity
has exact synonym: acetylglutamic-acetylornithine transacetylase activity
has exact synonym: acetylornithine glutamate acetyltransferase activity
has exact synonym: alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has exact synonym: glutamate acetyltransferase activity
has exact synonym: ornithine acetyltransferase activity
has exact synonym: ornithine transacetylase activity
has OBO namespace: molecular_function
id: GO:0004358
in subset: gosubset prok
type: Class
subclass of: GO_0008080

glutaminase activity
IAO_0000115: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
has db xref: EC:3.5.1.2
has db xref: MetaCyc:GLUTAMIN-RXN
has db xref: RHEA:15892
has db xref: Reactome:REACT_101863
has db xref: Reactome:REACT_108874
has db xref: Reactome:REACT_1700
has db xref: Reactome:REACT_30789
has db xref: Reactome:REACT_40104
has db xref: Reactome:REACT_81929
has db xref: Reactome:REACT_82434
has db xref: Reactome:REACT_84071
has db xref: Reactome:REACT_91801
has db xref: Reactome:REACT_94730
has db xref: Reactome:REACT_97500
has db xref: Reactome:REACT_98074
has db xref: Reactome:REACT_98880
has exact synonym: L-glutaminase activity
has exact synonym: L-glutamine amidohydrolase activity
has exact synonym: glutamine aminohydrolase activity
has OBO namespace: molecular_function
has related synonym: glutaminase I
id: GO:0004359
in subset: gosubset prok
type: Class
subclass of: GO_0016811

glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAO_0000115: Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.
has broad synonym: glucosaminephosphate isomerase
has db xref: EC:2.6.1.16
has db xref: KEGG:R00768
has db xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN
has db xref: RHEA:13240
has db xref: Reactome:REACT_22115
has exact synonym: D-fructose-6-phosphate amidotransferase activity
has exact synonym: GlcN6P synthase activity
has exact synonym: L-glutamine-D-fructose-6-phosphate amidotransferase activity
has exact synonym: L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
has exact synonym: glucosamine 6-phosphate synthase activity
has exact synonym: glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity
has exact synonym: glucosamine-6-phosphate isomerase (glutamine-forming) activity
has exact synonym: glucosamine-6-phosphate synthase activity
has exact synonym: hexosephosphate aminotransferase activity
has OBO namespace: molecular_function
id: GO:0004360
in subset: gosubset prok
type: Class
subclass of: GO_0070548

glutaryl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.
has db xref: EC:1.3.99.7
has db xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN
has db xref: RHEA:13392
has db xref: Reactome:REACT_108443
has db xref: Reactome:REACT_110967
has db xref: Reactome:REACT_1409
has db xref: Reactome:REACT_29149
has db xref: Reactome:REACT_79092
has db xref: Reactome:REACT_87295
has db xref: Reactome:REACT_93502
has db xref: Reactome:REACT_93650
has db xref: Reactome:REACT_94738
has db xref: Reactome:REACT_94848
has db xref: Reactome:REACT_96762
has db xref: Reactome:REACT_96865
has db xref: Reactome:REACT_97682
has db xref: Reactome:REACT_98305
has db xref: UM-BBD_reactionID:r0198
has exact synonym: glutaryl coenzyme A dehydrogenase activity
has exact synonym: glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)
has exact synonym: glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)
has OBO namespace: molecular_function
id: GO:0004361
in subset: gosubset prok
type: Class
subclass of: acyl-CoA dehydrogenase activity

glutathione-disulfide reductase activity
IAO_0000115: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
has db xref: EC:1.8.1.7
has db xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
has db xref: RHEA:11743
has db xref: Reactome:REACT_100755
has db xref: Reactome:REACT_105351
has db xref: Reactome:REACT_106052
has db xref: Reactome:REACT_107331
has db xref: Reactome:REACT_108894
has db xref: Reactome:REACT_2220
has db xref: Reactome:REACT_31135
has db xref: Reactome:REACT_33636
has db xref: Reactome:REACT_34766
has db xref: Reactome:REACT_82516
has db xref: Reactome:REACT_87466
has db xref: Reactome:REACT_91212
has db xref: Reactome:REACT_91373
has db xref: Reactome:REACT_93897
has db xref: Reactome:REACT_95299
has db xref: Reactome:REACT_95410
has db xref: Reactome:REACT_98360
has exact synonym: GSH reductase activity
has exact synonym: GSSG reductase activity
has exact synonym: NADPH-GSSG reductase activity
has exact synonym: NADPH-glutathione reductase activity
has exact synonym: NADPH:oxidized-glutathione oxidoreductase activity
has exact synonym: glutathione S-reductase activity
has exact synonym: glutathione reductase (NADPH) activity
has exact synonym: glutathione reductase activity
has exact synonym: glutathione-disulphide reductase activity
has exact synonym: glutathione:NADP+ oxidoreductase activity
has OBO namespace: molecular_function
has related synonym: oxidized glutathione reduction
id: GO:0004362
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:1.6.4.2.
subclass of: GO_0015038
subclass of: GO_0016209
subclass of: GO_0016668

glutathione synthase activity
IAO_0000115: Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
has db xref: EC:6.3.2.3
has db xref: KEGG:R00497
has db xref: MetaCyc:GLUTATHIONE-SYN-RXN
has db xref: RHEA:13560
has db xref: Reactome:REACT_100394
has db xref: Reactome:REACT_104397
has db xref: Reactome:REACT_105605
has db xref: Reactome:REACT_105891
has db xref: Reactome:REACT_108106
has db xref: Reactome:REACT_108848
has db xref: Reactome:REACT_6886
has db xref: Reactome:REACT_80709
has db xref: Reactome:REACT_81099
has db xref: Reactome:REACT_82957
has db xref: Reactome:REACT_84994
has db xref: Reactome:REACT_86625
has db xref: Reactome:REACT_86921
has db xref: Reactome:REACT_87951
has db xref: Reactome:REACT_90100
has db xref: Reactome:REACT_93797
has db xref: Reactome:REACT_99493
has db xref: Reactome:REACT_99980
has exact synonym: GSH synthetase activity
has exact synonym: gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
has exact synonym: glutathione synthetase activity
has OBO namespace: molecular_function
id: GO:0004363
in subset: gosubset prok
type: Class
subclass of: GO_0016881

glutathione transferase activity
IAO_0000115: Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
has db xref: EC:2.5.1.18
has db xref: MetaCyc:GSHTRAN-RXN
has db xref: Reactome:REACT_100785
has db xref: Reactome:REACT_101029
has db xref: Reactome:REACT_108390
has db xref: Reactome:REACT_110631
has db xref: Reactome:REACT_113981
has db xref: Reactome:REACT_114178
has db xref: Reactome:REACT_114437
has db xref: Reactome:REACT_114776
has db xref: Reactome:REACT_30282
has db xref: Reactome:REACT_32347
has db xref: Reactome:REACT_6854
has db xref: Reactome:REACT_6947
has db xref: Reactome:REACT_78100
has db xref: Reactome:REACT_78483
has db xref: Reactome:REACT_80590
has db xref: Reactome:REACT_83452
has db xref: Reactome:REACT_84786
has db xref: Reactome:REACT_84896
has db xref: Reactome:REACT_85283
has db xref: Reactome:REACT_85369
has db xref: Reactome:REACT_87985
has db xref: Reactome:REACT_89910
has db xref: Reactome:REACT_92411
has db xref: Reactome:REACT_93234
has db xref: Reactome:REACT_93830
has db xref: Reactome:REACT_94550
has db xref: Reactome:REACT_97954
has db xref: Reactome:REACT_98524
has db xref: Reactome:REACT_99142
has exact synonym: RX:glutathione R-transferase activity
has exact synonym: S-(hydroxyalkyl)glutathione lyase activity
has exact synonym: glutathione S-alkyl transferase activity
has exact synonym: glutathione S-alkyltransferase activity
has exact synonym: glutathione S-aralkyltransferase activity
has exact synonym: glutathione S-aryltransferase activity
has exact synonym: glutathione S-transferase activity
has exact synonym: glutathione conjugation reaction
has OBO namespace: molecular_function
id: GO:0004364
in subset: gosubset prok
type: Class
subclass of: GO_0016765

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IAO_0000115: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
has broad synonym: triosephosphate dehydrogenase activity
has db xref: EC:1.2.1.12
has db xref: MetaCyc:GAPOXNPHOSPHN-RXN
has db xref: RHEA:10303
has db xref: Reactome:REACT_100096
has db xref: Reactome:REACT_100121
has db xref: Reactome:REACT_101212
has db xref: Reactome:REACT_103017
has db xref: Reactome:REACT_103197
has db xref: Reactome:REACT_103214
has db xref: Reactome:REACT_104299
has db xref: Reactome:REACT_105091
has db xref: Reactome:REACT_106850
has db xref: Reactome:REACT_112334
has db xref: Reactome:REACT_112690
has db xref: Reactome:REACT_112805
has db xref: Reactome:REACT_113461
has db xref: Reactome:REACT_113644
has db xref: Reactome:REACT_113850
has db xref: Reactome:REACT_114520
has db xref: Reactome:REACT_115033
has db xref: Reactome:REACT_115268
has db xref: Reactome:REACT_115436
has db xref: Reactome:REACT_115700
has db xref: Reactome:REACT_115940
has db xref: Reactome:REACT_1593
has db xref: Reactome:REACT_1847
has db xref: Reactome:REACT_28184
has db xref: Reactome:REACT_32076
has db xref: Reactome:REACT_32485
has db xref: Reactome:REACT_77380
has db xref: Reactome:REACT_80434
has db xref: Reactome:REACT_80815
has db xref: Reactome:REACT_83464
has db xref: Reactome:REACT_85937
has db xref: Reactome:REACT_87656
has db xref: Reactome:REACT_89732
has db xref: Reactome:REACT_93301
has db xref: Reactome:REACT_95562
has db xref: Reactome:REACT_98283
has db xref: Reactome:REACT_99054
has db xref: Reactome:REACT_99793
has exact synonym: 3-phosphoglyceraldehyde dehydrogenase activity
has exact synonym: D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
has exact synonym: GAPDH activity
has exact synonym: NAD-dependent glyceraldehyde phosphate dehydrogenase activity
has exact synonym: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity
has exact synonym: NADH-glyceraldehyde phosphate dehydrogenase activity
has exact synonym: dehydrogenase, glyceraldehyde phosphate
has exact synonym: glyceraldehyde phosphate dehydrogenase (NAD)
has exact synonym: glyceraldehyde-3-P-dehydrogenase activity
has exact synonym: phosphoglyceraldehyde dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004365
in subset: gosubset prok
type: Class
subclass of: GO_0016620

glycerol-3-phosphate O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
has db xref: EC:2.3.1.15
has db xref: MetaCyc:RXN-1381
has db xref: RHEA:15328
has db xref: Reactome:REACT_102260
has db xref: Reactome:REACT_103249
has db xref: Reactome:REACT_104688
has db xref: Reactome:REACT_105427
has db xref: Reactome:REACT_106143
has db xref: Reactome:REACT_106172
has db xref: Reactome:REACT_109516
has db xref: Reactome:REACT_110268
has db xref: Reactome:REACT_112568
has db xref: Reactome:REACT_113073
has db xref: Reactome:REACT_114086
has db xref: Reactome:REACT_114724
has db xref: Reactome:REACT_22419
has db xref: Reactome:REACT_28205
has db xref: Reactome:REACT_29766
has db xref: Reactome:REACT_31766
has db xref: Reactome:REACT_32967
has db xref: Reactome:REACT_64502
has db xref: Reactome:REACT_78811
has db xref: Reactome:REACT_80589
has db xref: Reactome:REACT_81620
has db xref: Reactome:REACT_839
has db xref: Reactome:REACT_84188
has db xref: Reactome:REACT_85896
has db xref: Reactome:REACT_87756
has db xref: Reactome:REACT_93755
has db xref: Reactome:REACT_94514
has db xref: Reactome:REACT_96423
has exact synonym: 3-glycerophosphate acyltransferase activity
has exact synonym: ACP:sn-glycerol-3-phosphate acyltransferase activity
has exact synonym: acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity
has exact synonym: alpha-glycerophosphate acyltransferase activity
has exact synonym: glycerol 3-phosphate acyltransferase activity
has exact synonym: glycerol phosphate acyltransferase activity
has exact synonym: glycerol phosphate transacylase activity
has exact synonym: glycerophosphate acyltransferase activity
has exact synonym: glycerophosphate transacylase activity
has exact synonym: sn-glycerol 3-phosphate acyltransferase activity
has exact synonym: sn-glycerol-3-phosphate acyltransferase activity
has OBO namespace: molecular_function
id: GO:0004366
in subset: gosubset prok
type: Class
subclass of: GO_0008374

glycerol-3-phosphate dehydrogenase [NAD+] activity
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+.
has broad synonym: L-alpha-glycerol phosphate dehydrogenase activity
has broad synonym: L-alpha-glycerophosphate dehydrogenase activity
has broad synonym: L-glycerol phosphate dehydrogenase activity
has broad synonym: L-glycerophosphate dehydrogenase activity
has broad synonym: hydroglycerophosphate dehydrogenase activity
has db xref: EC:1.1.1.8
has db xref: MetaCyc:1.1.1.8-RXN
has db xref: RHEA:11095
has db xref: Reactome:REACT_102291
has db xref: Reactome:REACT_102745
has db xref: Reactome:REACT_109811
has db xref: Reactome:REACT_110408
has db xref: Reactome:REACT_113156
has db xref: Reactome:REACT_1146
has db xref: Reactome:REACT_115427
has db xref: Reactome:REACT_28453
has db xref: Reactome:REACT_33169
has db xref: Reactome:REACT_79475
has db xref: Reactome:REACT_95798
has db xref: Reactome:REACT_96371
has exact synonym: NAD-L-glycerol-3-phosphate dehydrogenase activity
has exact synonym: NAD-alpha-glycerophosphate dehydrogenase activity
has exact synonym: NAD-dependent glycerol phosphate dehydrogenase activity
has exact synonym: NAD-dependent glycerol-3-phosphate dehydrogenase activity
has exact synonym: NAD-linked glycerol 3-phosphate dehydrogenase activity
has exact synonym: alpha-glycerol phosphate dehydrogenase (NAD) activity
has exact synonym: alpha-glycerophosphate dehydrogenase (NAD) activity
has exact synonym: glycerol phosphate dehydrogenase (NAD) activity
has exact synonym: glycerol-3-phosphate dehydrogenase (NAD) activity
has exact synonym: glycerophosphate dehydrogenase (NAD) activity
has OBO namespace: molecular_function
has related synonym: NADH-dihydroxyacetone phosphate reductase activity
has related synonym: glycerol 1-phosphate dehydrogenase activity
id: GO:0004367
in subset: gosubset prok
type: Class
subclass of: GO_0016616

glycerol-3-phosphate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
has db xref: EC:1.1.5.3
has db xref: MetaCyc:RXN-9927
has db xref: MetaCyc:RXN0-5260
has db xref: RHEA:18980
has db xref: Reactome:REACT_100144
has db xref: Reactome:REACT_100249
has db xref: Reactome:REACT_102204
has db xref: Reactome:REACT_104083
has db xref: Reactome:REACT_104648
has db xref: Reactome:REACT_112809
has db xref: Reactome:REACT_114651
has db xref: Reactome:REACT_115394
has db xref: Reactome:REACT_16938
has db xref: Reactome:REACT_29747
has db xref: Reactome:REACT_31546
has db xref: Reactome:REACT_32782
has db xref: Reactome:REACT_74143
has db xref: Reactome:REACT_77515
has db xref: Reactome:REACT_80640
has db xref: Reactome:REACT_81759
has db xref: Reactome:REACT_88257
has db xref: Reactome:REACT_90197
has db xref: Reactome:REACT_90540
has db xref: Reactome:REACT_92766
has db xref: Reactome:REACT_99928
has exact synonym: FAD-dependent glycerol-3-phosphate dehydrogenase
has exact synonym: L-glycerophosphate dehydrogenase activity
has exact synonym: flavin-linked glycerol-3-phosphate dehydrogenase
has exact synonym: glycerol-3-phosphate CoQ reductase
has exact synonym: glycerophosphate dehydrogenase activity
has exact synonym: sn-glycerol-3-phosphate dehydrogenase activity
has exact synonym: sn-glycerol-3-phosphate:quinone oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004368
in subset: gosubset prok
type: Class
comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591.
subclass of: GO_0016901

glycerol-3-phosphate oxidase activity
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2).
has db xref: EC:1.1.3.21
has db xref: KEGG:R00846
has db xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN
has db xref: RHEA:18372
has exact synonym: L-alpha-glycerol-3-phosphate oxidase activity
has exact synonym: L-alpha-glycerophosphate oxidase activity
has exact synonym: alpha-glycerophosphate oxidase activity
has exact synonym: glycerol phosphate oxidase activity
has exact synonym: glycerol-1-phosphate oxidase activity
has exact synonym: sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004369
in subset: gosubset prok
type: Class
subclass of: GO_0016899

glycerol kinase activity
IAO_0000115: Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).
has db xref: EC:2.7.1.30
has db xref: KEGG:R00847
has db xref: MetaCyc:GLYCEROL-KIN-RXN
has db xref: RHEA:21647
has db xref: Reactome:REACT_724
has exact synonym: ATP:glycerol 3-phosphotransferase activity
has exact synonym: ATP:glycerol-3-phosphotransferase activity
has exact synonym: glyceric kinase activity
has exact synonym: glycerokinase activity
has exact synonym: glycerol kinase (phosphorylating)
has OBO namespace: molecular_function
has related synonym: GK
id: GO:0004370
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

glycerone kinase activity
IAO_0000115: Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).
has db xref: EC:2.7.1.29
has db xref: KEGG:R01011
has db xref: MetaCyc:GLYCERONE-KINASE-RXN
has db xref: RHEA:15776
has exact synonym: ATP:glycerone phosphotransferase activity
has exact synonym: acetol kinase (phosphorylating)
has exact synonym: acetol kinase activity
has exact synonym: dihydroxyacetone kinase activity
has OBO namespace: molecular_function
id: GO:0004371
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

glycine hydroxymethyltransferase activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
has db xref: EC:2.1.2.1
has db xref: MetaCyc:GLYOHMETRANS-RXN
has db xref: RHEA:15484
has db xref: Reactome:REACT_100551
has db xref: Reactome:REACT_101143
has db xref: Reactome:REACT_103730
has db xref: Reactome:REACT_104026
has db xref: Reactome:REACT_105838
has db xref: Reactome:REACT_106100
has db xref: Reactome:REACT_106938
has db xref: Reactome:REACT_108889
has db xref: Reactome:REACT_109080
has db xref: Reactome:REACT_110497
has db xref: Reactome:REACT_110666
has db xref: Reactome:REACT_110712
has db xref: Reactome:REACT_110780
has db xref: Reactome:REACT_111007
has db xref: Reactome:REACT_11108
has db xref: Reactome:REACT_11159
has db xref: Reactome:REACT_112625
has db xref: Reactome:REACT_112714
has db xref: Reactome:REACT_113302
has db xref: Reactome:REACT_113467
has db xref: Reactome:REACT_114244
has db xref: Reactome:REACT_114305
has db xref: Reactome:REACT_114385
has db xref: Reactome:REACT_114576
has db xref: Reactome:REACT_115121
has db xref: Reactome:REACT_1345
has db xref: Reactome:REACT_30943
has db xref: Reactome:REACT_31482
has db xref: Reactome:REACT_31564
has db xref: Reactome:REACT_31591
has db xref: Reactome:REACT_33927
has db xref: Reactome:REACT_33932
has db xref: Reactome:REACT_34223
has db xref: Reactome:REACT_77050
has db xref: Reactome:REACT_77924
has db xref: Reactome:REACT_78152
has db xref: Reactome:REACT_80167
has db xref: Reactome:REACT_80412
has db xref: Reactome:REACT_81468
has db xref: Reactome:REACT_82542
has db xref: Reactome:REACT_84260
has db xref: Reactome:REACT_86594
has db xref: Reactome:REACT_88214
has db xref: Reactome:REACT_88519
has db xref: Reactome:REACT_89705
has db xref: Reactome:REACT_90130
has db xref: Reactome:REACT_90410
has db xref: Reactome:REACT_91337
has db xref: Reactome:REACT_91776
has db xref: Reactome:REACT_92924
has db xref: Reactome:REACT_93345
has db xref: Reactome:REACT_93885
has db xref: Reactome:REACT_95280
has db xref: Reactome:REACT_95373
has db xref: Reactome:REACT_95737
has db xref: Reactome:REACT_97896
has db xref: Reactome:REACT_99194
has exact synonym: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity
has exact synonym: L-serine hydroxymethyltransferase activity
has exact synonym: allothreonine aldolase activity
has exact synonym: serine aldolase activity
has exact synonym: serine hydroxymethylase activity
has exact synonym: serine hydroxymethyltransferase activity
has exact synonym: serine transhydroxymethylase activity
has OBO namespace: molecular_function
id: GO:0004372
in subset: gosubset prok
type: Class
subclass of: GO_0016742

glycogen (starch) synthase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).
has db xref: EC:2.4.1.11
has db xref: MetaCyc:2.4.1.11-RXN
has db xref: Reactome:REACT_101890
has db xref: Reactome:REACT_1053
has db xref: Reactome:REACT_108629
has db xref: Reactome:REACT_110198
has db xref: Reactome:REACT_1169
has db xref: Reactome:REACT_29331
has db xref: Reactome:REACT_29979
has db xref: Reactome:REACT_32243
has db xref: Reactome:REACT_33183
has db xref: Reactome:REACT_34684
has db xref: Reactome:REACT_77029
has db xref: Reactome:REACT_78218
has db xref: Reactome:REACT_80007
has db xref: Reactome:REACT_80691
has db xref: Reactome:REACT_83229
has db xref: Reactome:REACT_87238
has db xref: Reactome:REACT_89103
has db xref: Reactome:REACT_89171
has db xref: Reactome:REACT_91264
has db xref: Reactome:REACT_91828
has db xref: Reactome:REACT_92346
has db xref: Reactome:REACT_93795
has db xref: Reactome:REACT_95212
has db xref: Reactome:REACT_95765
has exact synonym: UDP-glucose-glycogen glucosyltransferase activity
has exact synonym: UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity
has exact synonym: UDP-glycogen synthase activity
has exact synonym: UDPG-glycogen synthetase activity
has exact synonym: UDPG-glycogen transglucosylase activity
has exact synonym: UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity
has exact synonym: glycogen (starch) synthetase activity
has exact synonym: uridine diphosphoglucose-glycogen glucosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004373
in subset: gosubset prok
type: Class
subclass of: GO_0035251

glycine cleavage system
IAO_0000115: OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating).
IAO_0100001: GO:0019464
has broad synonym: glycine synthase
has OBO namespace: molecular_function
id: GO:0004374
type: Class
comment: This term was made obsolete because it represents a process rather than a function.
deprecated: true

glycine dehydrogenase (decarboxylating) activity
IAO_0000115: Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.
has db xref: EC:1.4.4.2
has db xref: MetaCyc:GCVP-RXN
has exact synonym: glycine decarboxylase activity
has exact synonym: glycine-cleavage complex P-protein activity
has exact synonym: glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
has exact synonym: glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
has narrow synonym: P-protein
has narrow synonym: glycine cleavage system P-protein activity
has narrow synonym: protein P1
has OBO namespace: molecular_function
has related synonym: glycine-cleavage complex
id: GO:0004375
in subset: gosubset prok
type: Class
subclass of: GO_0016642

glycolipid mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.
has alternative id: GO:0004580
has db xref: EC:2.4.1.-
has db xref: Reactome:REACT_101404
has db xref: Reactome:REACT_103363
has db xref: Reactome:REACT_103767
has db xref: Reactome:REACT_104167
has db xref: Reactome:REACT_105006
has db xref: Reactome:REACT_107148
has db xref: Reactome:REACT_108534
has db xref: Reactome:REACT_109154
has db xref: Reactome:REACT_111941
has db xref: Reactome:REACT_1308
has db xref: Reactome:REACT_1848
has db xref: Reactome:REACT_31390
has db xref: Reactome:REACT_32639
has db xref: Reactome:REACT_33046
has db xref: Reactome:REACT_33165
has db xref: Reactome:REACT_78709
has db xref: Reactome:REACT_78994
has db xref: Reactome:REACT_79695
has db xref: Reactome:REACT_79740
has db xref: Reactome:REACT_81302
has db xref: Reactome:REACT_84714
has db xref: Reactome:REACT_85880
has db xref: Reactome:REACT_86157
has db xref: Reactome:REACT_87246
has db xref: Reactome:REACT_88387
has db xref: Reactome:REACT_89761
has db xref: Reactome:REACT_90584
has db xref: Reactome:REACT_92255
has db xref: Reactome:REACT_93107
has db xref: Reactome:REACT_94013
has db xref: Reactome:REACT_96422
has db xref: Reactome:REACT_97884
has db xref: Reactome:REACT_98938
has db xref: Reactome:REACT_99322
has db xref: Reactome:REACT_99674
has exact synonym: glycolipid mannosyl transferase activity
has OBO namespace: molecular_function
id: GO:0004376
type: Class
subclass of: mannosyltransferase activity

GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
has db xref: EC:2.4.1.131
has db xref: MetaCyc:2.4.1.131-RXN
has db xref: RHEA:29526
has exact synonym: GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
has exact synonym: GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
has exact synonym: GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
has exact synonym: glycolipid 2-alpha-mannosyltransferase activity
has exact synonym: guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
has exact synonym: oligosaccharide-lipid mannosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004377
type: Class
subclass of: alpha-1,2-mannosyltransferase activity
subclass of: glycolipid mannosyltransferase activity

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.
has db xref: EC:2.4.1.132
has db xref: MetaCyc:2.4.1.132-RXN
has db xref: RHEA:29518
has exact synonym: GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity
has exact synonym: GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity
has exact synonym: glycolipid 3-alpha-mannosyltransferase activity
has exact synonym: guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity
has exact synonym: mannosyltransferase II activity
has OBO namespace: molecular_function
has related synonym: GDP-mannose-oligosaccharide-lipid mannosyltransferase II
id: GO:0004378
type: Class
subclass of: glycolipid mannosyltransferase activity

glycylpeptide N-tetradecanoyltransferase activity
IAO_0000115: Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
has alternative id: GO:0019106
has db xref: EC:2.3.1.97
has db xref: MetaCyc:2.3.1.97-RXN
has db xref: Reactome:REACT_115774
has exact synonym: N-myristoyltransferase activity
has exact synonym: myristoyl-CoA-protein N-myristoyltransferase activity
has exact synonym: myristoyl-coenzyme A:protein N-myristoyl transferase activity
has exact synonym: peptide N-myristoyltransferase activity
has exact synonym: peptide N-tetradecanoyltransferase activity
has exact synonym: protein N-myristoyltransferase activity
has exact synonym: tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity
has OBO namespace: molecular_function
has related synonym: myristoylating enzymes
id: GO:0004379
type: Class
subclass of: GO_0016410
subclass of: GO_0019107

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
has db xref: EC:2.4.1.40
has db xref: MetaCyc:2.4.1.40-RXN
has exact synonym: A-transferase activity
has exact synonym: UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
has exact synonym: alpha-3-N-acetylgalactosaminyltransferase activity
has exact synonym: blood-group substance A-dependent acetylgalactosaminyltransferase activity
has exact synonym: blood-group substance alpha-acetyltransferase activity
has exact synonym: fucosylgalactose acetylgalactosaminyltransferase activity
has exact synonym: fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity
has exact synonym: fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity
has exact synonym: histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)
has narrow synonym: histo-blood group A acetylgalactosaminyltransferase activity
has OBO namespace: molecular_function
has related synonym: A transferase activity
has related synonym: histo-blood group A transferase activity
id: GO:0004380
type: Class
subclass of: GO_0008376

fucosylgalactoside 3-alpha-galactosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
has db xref: EC:2.4.1.37
has db xref: MetaCyc:2.4.1.37-RXN
has db xref: RHEA:14352
has exact synonym: UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity
has exact synonym: fucosylglycoprotein 3-alpha-galactosyltransferase activity
has exact synonym: glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity
has exact synonym: histo-blood substance B-dependent galactosyltransferase activity
has narrow synonym: [blood group substance] alpha-galactosyltransferase activity
has narrow synonym: blood-group substance B-dependent galactosyltransferase activity
has narrow synonym: blood-group substance beta-dependent galactosyltransferase activity
has narrow synonym: histo-blood group B transferase activity
has narrow synonym: histo-blood substance beta-dependent galactosyltransferase activity
has OBO namespace: molecular_function
has related synonym: B transferase activity
id: GO:0004381
type: Class
subclass of: GO_0035250

guanosine-diphosphatase activity
IAO_0000115: Catalysis of the reaction: GDP + H2O = GMP + phosphate.
has db xref: EC:3.6.1.42
has db xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN
has db xref: RHEA:22159
has exact synonym: GDP phosphohydrolase activity
has exact synonym: GDPase activity
has exact synonym: guanosine 5'-diphosphatase activity
has exact synonym: guanosine diphosphatase activity
has OBO namespace: molecular_function
id: GO:0004382
type: Class
subclass of: GO_0017110

guanylate cyclase activity
IAO_0000115: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
has db xref: EC:4.6.1.2
has db xref: MetaCyc:GUANYLCYC-RXN
has db xref: RHEA:13668
has db xref: Reactome:REACT_108080
has db xref: Reactome:REACT_115231
has db xref: Reactome:REACT_115362
has db xref: Reactome:REACT_23790
has db xref: Reactome:REACT_23978
has db xref: Reactome:REACT_29218
has db xref: Reactome:REACT_30126
has db xref: Reactome:REACT_31354
has db xref: Reactome:REACT_32985
has db xref: Reactome:REACT_83069
has db xref: Reactome:REACT_85642
has db xref: Reactome:REACT_90434
has db xref: Reactome:REACT_96120
has exact synonym: GTP diphosphate-lyase (cyclizing) activity
has exact synonym: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
has exact synonym: guanyl cyclase activity
has exact synonym: guanylyl cyclase activity
has narrow synonym: receptor guanylate cyclase activity
has OBO namespace: molecular_function
id: GO:0004383
in subset: gosubset prok
type: Class
subclass of: GO_0009975
subclass of: GO_0016849

membrane-associated guanylate kinase
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane.
consider: GO:0004385
consider: GO:0005102
consider: GO:0007155
consider: GO:0016021
consider: GO:0050839
has exact synonym: MAGUK
has OBO namespace: molecular_function
id: GO:0004384
type: Class
comment: This term was made obsolete because it represents a gene product and not a function.
deprecated: true

guanylate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + GMP = ADP + GDP.
has db xref: EC:2.7.4.8
has db xref: MetaCyc:GUANYL-KIN-RXN
has db xref: RHEA:20783
has db xref: Reactome:REACT_104133
has db xref: Reactome:REACT_106028
has db xref: Reactome:REACT_106389
has db xref: Reactome:REACT_108666
has db xref: Reactome:REACT_109318
has db xref: Reactome:REACT_110939
has db xref: Reactome:REACT_112127
has db xref: Reactome:REACT_114888
has db xref: Reactome:REACT_115196
has db xref: Reactome:REACT_115456
has db xref: Reactome:REACT_1256
has db xref: Reactome:REACT_1606
has db xref: Reactome:REACT_28761
has db xref: Reactome:REACT_31188
has db xref: Reactome:REACT_31346
has db xref: Reactome:REACT_31866
has db xref: Reactome:REACT_33129
has db xref: Reactome:REACT_33400
has db xref: Reactome:REACT_33774
has db xref: Reactome:REACT_81686
has db xref: Reactome:REACT_84577
has db xref: Reactome:REACT_85414
has db xref: Reactome:REACT_86007
has db xref: Reactome:REACT_86484
has db xref: Reactome:REACT_89391
has db xref: Reactome:REACT_90955
has db xref: Reactome:REACT_91717
has db xref: Reactome:REACT_99219
has exact synonym: 5'-GMP kinase activity
has exact synonym: ATP:(d)GMP phosphotransferase activity
has exact synonym: ATP:GMP phosphotransferase activity
has exact synonym: GMP kinase activity
has exact synonym: guanosine monophosphate kinase activity
has narrow synonym: membrane-associated guanylate kinase
has OBO namespace: molecular_function
has related synonym: deoxyguanylate kinase activity
id: GO:0004385
in subset: gosubset prok
type: Class
subclass of: GO_0016776
subclass of: GO_0019201

helicase activity
IAO_0000115: Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
has db xref: Reactome:REACT_101111
has db xref: Reactome:REACT_101247
has db xref: Reactome:REACT_101622
has db xref: Reactome:REACT_101644
has db xref: Reactome:REACT_101823
has db xref: Reactome:REACT_101994
has db xref: Reactome:REACT_102121
has db xref: Reactome:REACT_102441
has db xref: Reactome:REACT_102560
has db xref: Reactome:REACT_1033
has db xref: Reactome:REACT_103861
has db xref: Reactome:REACT_103881
has db xref: Reactome:REACT_103897
has db xref: Reactome:REACT_103959
has db xref: Reactome:REACT_104221
has db xref: Reactome:REACT_105950
has db xref: Reactome:REACT_106346
has db xref: Reactome:REACT_107072
has db xref: Reactome:REACT_107495
has db xref: Reactome:REACT_108159
has db xref: Reactome:REACT_108648
has db xref: Reactome:REACT_108654
has db xref: Reactome:REACT_109035
has db xref: Reactome:REACT_109161
has db xref: Reactome:REACT_110588
has db xref: Reactome:REACT_110827
has db xref: Reactome:REACT_110845
has db xref: Reactome:REACT_112208
has db xref: Reactome:REACT_112817
has db xref: Reactome:REACT_113177
has db xref: Reactome:REACT_1521
has db xref: Reactome:REACT_1817
has db xref: Reactome:REACT_1844
has db xref: Reactome:REACT_28131
has db xref: Reactome:REACT_28343
has db xref: Reactome:REACT_28810
has db xref: Reactome:REACT_28880
has db xref: Reactome:REACT_29155
has db xref: Reactome:REACT_29217
has db xref: Reactome:REACT_29818
has db xref: Reactome:REACT_29850
has db xref: Reactome:REACT_30013
has db xref: Reactome:REACT_30989
has db xref: Reactome:REACT_31034
has db xref: Reactome:REACT_31090
has db xref: Reactome:REACT_31554
has db xref: Reactome:REACT_32533
has db xref: Reactome:REACT_33205
has db xref: Reactome:REACT_34016
has db xref: Reactome:REACT_34089
has db xref: Reactome:REACT_34560
has db xref: Reactome:REACT_40
has db xref: Reactome:REACT_6134
has db xref: Reactome:REACT_6184
has db xref: Reactome:REACT_6325
has db xref: Reactome:REACT_6758
has db xref: Reactome:REACT_6768
has db xref: Reactome:REACT_6853
has db xref: Reactome:REACT_6922
has db xref: Reactome:REACT_78086
has db xref: Reactome:REACT_78462
has db xref: Reactome:REACT_78667
has db xref: Reactome:REACT_78771
has db xref: Reactome:REACT_79759
has db xref: Reactome:REACT_80107
has db xref: Reactome:REACT_80325
has db xref: Reactome:REACT_80500
has db xref: Reactome:REACT_80532
has db xref: Reactome:REACT_80605
has db xref: Reactome:REACT_81126
has db xref: Reactome:REACT_81335
has db xref: Reactome:REACT_81427
has db xref: Reactome:REACT_81441
has db xref: Reactome:REACT_81682
has db xref: Reactome:REACT_82776
has db xref: Reactome:REACT_83794
has db xref: Reactome:REACT_84565
has db xref: Reactome:REACT_84574
has db xref: Reactome:REACT_84809

heme oxygenase (decyclizing) activity
IAO_0000115: Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O.
has db xref: EC:1.14.99.3
has db xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN
has db xref: Reactome:REACT_22100
has db xref: Reactome:REACT_29672
has db xref: Reactome:REACT_32670
has db xref: Reactome:REACT_34442
has db xref: Reactome:REACT_44544
has db xref: Reactome:REACT_80835
has db xref: Reactome:REACT_86213
has db xref: Reactome:REACT_91230
has db xref: Reactome:REACT_91796
has db xref: Reactome:REACT_99289
has db xref: Reactome:REACT_99482
has exact synonym: haem oxidase activity
has exact synonym: haem oxygenase (decyclizing) activity
has exact synonym: haem oxygenase activity
has exact synonym: heme oxidase activity
has exact synonym: heme oxygenase activity
has exact synonym: heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
has OBO namespace: molecular_function
has related synonym: ORP33 proteins
id: GO:0004392
type: Class
subclass of: GO_0016705

heparan sulfate 2-O-sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.
has db xref: EC:2.8.2.-
has exact synonym: heparan-sulfate 2-O-sulphotransferase activity
has OBO namespace: molecular_function
has related synonym: heparin 2-sulfotransferase activity
has related synonym: heparin-sulphate 2-sulphotransferase activity
id: GO:0004394
type: Class
subclass of: GO_0034483

hexaprenyldihydroxybenzoate methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.
has db xref: EC:2.1.1.114
has db xref: MetaCyc:2.1.1.114-RXN
has db xref: RHEA:14124
has exact synonym: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity
has exact synonym: DHHB methyltransferase activity
has exact synonym: DHHB-Mt activity
has exact synonym: S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity
has exact synonym: dihydroxyhexaprenylbenzoate methyltransferase activity
has OBO namespace: molecular_function
id: GO:0004395
type: Class
subclass of: GO_0010420

hexokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
has db xref: EC:2.7.1.1
has db xref: MetaCyc:HEXOKINASE-RXN
has db xref: RHEA:22743
has exact synonym: ATP-dependent hexokinase activity
has exact synonym: ATP:D-hexose 6-phosphotransferase activity
has exact synonym: glucose ATP phosphotransferase activity
has exact synonym: hexokinase (phosphorylating)
has exact synonym: hexokinase type IV glucokinase activity
has narrow synonym: hexokinase type I activity
has narrow synonym: hexokinase type II activity
has narrow synonym: hexokinase type III activity
has narrow synonym: hexokinase type IV (glucokinase) activity
has OBO namespace: molecular_function
has related synonym: hexokinase D
has related synonym: hexokinase type IV
id: GO:0004396
in subset: gosubset prok
type: Class
subclass of: GO_0016773
subclass of: GO_0019200

histidine ammonia-lyase activity
IAO_0000115: Catalysis of the reaction: L-histidine = urocanate + NH3.
has db xref: EC:4.3.1.3
has db xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN
has db xref: RHEA:21235
has db xref: Reactome:REACT_107886
has db xref: Reactome:REACT_1225
has db xref: Reactome:REACT_31362
has db xref: Reactome:REACT_31818
has db xref: Reactome:REACT_33743
has db xref: Reactome:REACT_77456
has db xref: Reactome:REACT_78794
has db xref: Reactome:REACT_81416
has db xref: Reactome:REACT_82994
has db xref: Reactome:REACT_83342
has db xref: Reactome:REACT_86125
has db xref: Reactome:REACT_94858
has db xref: Reactome:REACT_97533
has exact synonym: L-histidine ammonia-lyase (urocanate-forming)
has exact synonym: L-histidine ammonia-lyase activity
has OBO namespace: molecular_function
has related synonym: histidase activity
has related synonym: histidinase activity
has related synonym: histidine alpha-deaminase activity
id: GO:0004397
in subset: gosubset prok
type: Class
subclass of: GO_0016841

histidine decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-histidine = histamine + CO2.
has db xref: EC:4.1.1.22
has db xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN
has db xref: RHEA:20843
has db xref: Reactome:REACT_115661
has exact synonym: L-histidine carboxy-lyase (histamine-forming)
has exact synonym: L-histidine carboxy-lyase activity
has exact synonym: L-histidine decarboxylase activity
has OBO namespace: molecular_function
id: GO:0004398
in subset: gosubset prok
type: Class
subclass of: GO_0016831

histidinol dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+.
has db xref: EC:1.1.1.23
has db xref: MetaCyc:HISTALDEHYD-RXN
has db xref: MetaCyc:HISTOLDEHYD-RXN
has db xref: RHEA:20644
has OBO namespace: molecular_function
id: GO:0004399
in subset: gosubset prok
type: Class
subclass of: GO_0016616

histidinol-phosphate transaminase activity
IAO_0000115: Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
has db xref: EC:2.6.1.9
has db xref: MetaCyc:HISTAMINOTRANS-RXN
has db xref: RHEA:23747
has exact synonym: IAP transaminase activity
has exact synonym: L-histidinol phosphate aminotransferase activity
has exact synonym: L-histidinol-phosphate:2-oxoglutarate aminotransferase activity
has exact synonym: glutamic-imidazoleacetol phosphate transaminase activity
has exact synonym: histidine:imidazoleacetol phosphate transaminase activity
has exact synonym: histidinol phosphate aminotransferase activity
has exact synonym: histidinol-phosphate aminotransferase activity
has exact synonym: imidazole acetol-phosphate transaminase activity
has exact synonym: imidazoleacetol phosphate transaminase activity
has exact synonym: imidazolylacetolphosphate aminotransferase activity
has exact synonym: imidazolylacetolphosphate transaminase activity
has OBO namespace: molecular_function
id: GO:0004400
in subset: gosubset prok
type: Class
subclass of: GO_0008483

histidinol-phosphatase activity
IAO_0000115: Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
has db xref: EC:3.1.3.15
has db xref: KEGG:R03013
has db xref: MetaCyc:HISTIDPHOS-RXN
has db xref: RHEA:14468
has exact synonym: HPpase activity
has exact synonym: L-histidinol phosphate phosphatase activity
has exact synonym: L-histidinol-phosphate phosphohydrolase activity
has exact synonym: histidinol phosphate phosphatase activity
has exact synonym: histidinolphosphatase activity
has exact synonym: histidinolphosphate phosphatase activity
has OBO namespace: molecular_function
id: GO:0004401
in subset: gosubset prok
type: Class
subclass of: GO_0016791

histone acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
has alternative id: GO:0004403
has alternative id: GO:0004404
has alternative id: GO:0004405
has alternative id: GO:0004406
has alternative id: GO:0043166
has alternative id: GO:0046971
has db xref: EC:2.3.1.48
has db xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN
has exact synonym: acetyl-CoA:histone acetyltransferase activity
has exact synonym: histone acetokinase activity
has exact synonym: histone acetylase activity
has exact synonym: histone lysine acetyltransferase activity
has exact synonym: histone transacetylase activity
has narrow synonym: H2A/H2B histone acetyltransferase activity
has narrow synonym: H3/H4 histone acetyltransferase activity
has narrow synonym: H4/H2 histone acetyltransferase activity
has narrow synonym: H4/H2A acetyltransferase activity
has OBO namespace: molecular_function
has related synonym: nucleosome-histone acetyltransferase activity
id: GO:0004402
type: Class
comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant.
subclass of: GO_0008080

histone deacetylase activity
IAO_0000115: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
has db xref: EC:3.5.1.-
has db xref: MetaCyc:3.5.1.98-RXN
has OBO namespace: molecular_function
id: GO:0004407
type: Class
subclass of: GO_0016811
subclass of: GO_0033558

holocytochrome-c synthase activity
IAO_0000115: Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.
has db xref: EC:4.4.1.17
has db xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN
has exact synonym: cytochrome c heme-lyase activity
has exact synonym: holocytochrome c synthetase activity
has exact synonym: holocytochrome-c apocytochrome-c-lyase (heme-forming)
has exact synonym: holocytochrome-c apocytochrome-c-lyase activity
has OBO namespace: molecular_function
has related synonym: cytochrome c synthase activity
id: GO:0004408
in subset: gosubset prok
type: Class
subclass of: GO_0016846

homoaconitate hydratase activity
IAO_0000115: Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O.
has db xref: EC:4.2.1.36
has db xref: KEGG:R04371
has db xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN
has db xref: RHEA:15488
has exact synonym: 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity
has exact synonym: HACN activity
has exact synonym: cis-homoaconitase activity
has exact synonym: homoaconitase activity
has OBO namespace: molecular_function
has related synonym: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]
has related synonym: Lys4
has related synonym: LysF
id: GO:0004409
in subset: gosubset prok
type: Class
subclass of: GO_0016836

homocitrate synthase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
has db xref: EC:2.3.3.14
has db xref: KEGG:R00271
has db xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN
has db xref: RHEA:12932
has exact synonym: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity
has exact synonym: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
has exact synonym: acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
has exact synonym: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity
has exact synonym: homocitrate synthetase activity
has OBO namespace: molecular_function
id: GO:0004410
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.3.21.
subclass of: GO_0046912

homogentisate 1,2-dioxygenase activity
IAO_0000115: Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
has db xref: EC:1.13.11.5
has db xref: KEGG:R02519
has db xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN
has db xref: RHEA:15452
has db xref: Reactome:REACT_103052
has db xref: Reactome:REACT_103099
has db xref: Reactome:REACT_109538
has db xref: Reactome:REACT_110237
has db xref: Reactome:REACT_110856
has db xref: Reactome:REACT_28670
has db xref: Reactome:REACT_34678
has db xref: Reactome:REACT_34681
has db xref: Reactome:REACT_557
has db xref: Reactome:REACT_77468
has db xref: Reactome:REACT_84706
has db xref: Reactome:REACT_90899
has db xref: Reactome:REACT_93178
has db xref: Reactome:REACT_98158
has db xref: UM-BBD_reactionID:r0105
has exact synonym: homogentisate dioxygenase activity
has exact synonym: homogentisate oxidase activity
has exact synonym: homogentisate oxygenase activity
has exact synonym: homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
has exact synonym: homogentisic acid oxidase activity
has exact synonym: homogentisic acid oxygenase activity
has exact synonym: homogentisic oxygenase activity
has exact synonym: homogentisicase activity
has OBO namespace: molecular_function
id: GO:0004411
in subset: gosubset prok
type: Class
subclass of: GO_0016702

homoserine dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.
has db xref: EC:1.1.1.3
has db xref: MetaCyc:HOMOSERDEHYDROG-RXN
has db xref: RHEA:15764
has OBO namespace: molecular_function
id: GO:0004412
in subset: gosubset prok
type: Class
subclass of: GO_0016616

homoserine kinase activity
IAO_0000115: Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).
has db xref: EC:2.7.1.39
has db xref: KEGG:R01771
has db xref: MetaCyc:HOMOSERKIN-RXN
has db xref: RHEA:13988
has exact synonym: ATP:L-homoserine O-phosphotransferase activity
has exact synonym: homoserine kinase (phosphorylating)
has OBO namespace: molecular_function
has related synonym: HSK
id: GO:0004413
in subset: gosubset prok
type: Class
subclass of: GO_0016773
subclass of: GO_0019202

homoserine O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.
has broad synonym: homoserine transacetylase activity
has db xref: EC:2.3.1.31
has db xref: KEGG:R01776
has db xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN
has db xref: RHEA:13704
has exact synonym: L-homoserine O-acetyltransferase activity
has exact synonym: acetyl-CoA:L-homoserine O-acetyltransferase activity
has exact synonym: homoserine O-trans-acetylase activity
has exact synonym: homoserine acetyltransferase activity
has exact synonym: homoserine-O-transacetylase activity
has OBO namespace: molecular_function
id: GO:0004414
in subset: gosubset prok
type: Class
subclass of: GO_0016413

hyalurononglucosaminidase activity
IAO_0000115: Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
has broad synonym: chondroitinase activity
has broad synonym: hyaluronidase activity
has db xref: EC:3.2.1.35
has db xref: MetaCyc:3.2.1.35-RXN
has exact synonym: chondroitinase I activity
has exact synonym: hyaluronate 4-glycanohydrolase activity
has exact synonym: hyaluronoglucosaminidase activity
has exact synonym: hyaluronoglucosidase activity
has OBO namespace: molecular_function
id: GO:0004415
in subset: gosubset prok
type: Class
subclass of: GO_0015929

hydroxyacylglutathione hydrolase activity
IAO_0000115: Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
has db xref: EC:3.1.2.6
has db xref: MetaCyc:GLYOXII-RXN
has db xref: RHEA:25248
has exact synonym: S-(2-hydroxyacyl)glutathione hydrolase activity
has exact synonym: S-2-hydroxylacylglutathione hydrolase activity
has exact synonym: acetoacetylglutathione hydrolase activity
has exact synonym: glyoxalase II activity
has OBO namespace: molecular_function
id: GO:0004416
in subset: gosubset prok
type: Class
subclass of: GO_0016790

hydroxyethylthiazole kinase activity
IAO_0000115: Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+).
has db xref: EC:2.7.1.50
has db xref: KEGG:R04448
has db xref: MetaCyc:THIAZOLSYN3-RXN
has db xref: RHEA:24215
has exact synonym: 4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity
has exact synonym: ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity
has exact synonym: hydroxyethylthiazole kinase (phosphorylating)
has OBO namespace: molecular_function
id: GO:0004417
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

hydroxymethylbilane synthase activity
IAO_0000115: Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
has db xref: EC:2.5.1.61
has db xref: KEGG:R00084
has db xref: MetaCyc:OHMETHYLBILANESYN-RXN
has db xref: RHEA:13188
has db xref: Reactome:REACT_111975
has db xref: Reactome:REACT_112064
has db xref: Reactome:REACT_112125
has db xref: Reactome:REACT_112182
has db xref: Reactome:REACT_112379
has db xref: Reactome:REACT_112891
has db xref: Reactome:REACT_112987
has db xref: Reactome:REACT_113671
has db xref: Reactome:REACT_113741
has db xref: Reactome:REACT_113842
has db xref: Reactome:REACT_113975
has db xref: Reactome:REACT_113989
has db xref: Reactome:REACT_114353
has db xref: Reactome:REACT_114418
has db xref: Reactome:REACT_114514
has db xref: Reactome:REACT_114679
has db xref: Reactome:REACT_114680
has db xref: Reactome:REACT_115346
has db xref: Reactome:REACT_116165
has db xref: Reactome:REACT_9446
has exact synonym: (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
has exact synonym: (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
has exact synonym: HMB-synthase activity
has exact synonym: porphobilinogen ammonia-lyase (polymerizing)
has exact synonym: porphobilinogen deaminase activity
has exact synonym: porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
has exact synonym: pre-uroporphyrinogen synthase activity
has exact synonym: uroporphyrinogen synthase activity
has exact synonym: uroporphyrinogen synthetase activity
has narrow synonym: uroporphyrinogen I synthase activity
has narrow synonym: uroporphyrinogen I synthetase activity
has OBO namespace: molecular_function
id: GO:0004418
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.3.1.8.
subclass of: GO_0016765

hydroxymethylglutaryl-CoA lyase activity
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.
has db xref: EC:4.1.3.4
has db xref: KEGG:R01360
has db xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
has db xref: RHEA:24407
has db xref: Reactome:REACT_100202
has db xref: Reactome:REACT_104457
has db xref: Reactome:REACT_105243
has db xref: Reactome:REACT_108952
has db xref: Reactome:REACT_110966
has db xref: Reactome:REACT_2103
has db xref: Reactome:REACT_29720
has db xref: Reactome:REACT_31175
has db xref: Reactome:REACT_86954
has db xref: Reactome:REACT_89460
has db xref: Reactome:REACT_90800
has db xref: Reactome:REACT_91737
has db xref: Reactome:REACT_99837
has db xref: Reactome:REACT_99898
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity
has exact synonym: 3-hydroxy-3-methylglutarate-CoA lyase activity
has exact synonym: 3-hydroxy-3-methylglutaryl coenzyme A lyase activity
has exact synonym: 3-hydroxy-3-methylglutaryl-CoA lyase activity
has exact synonym: HMG-CoA lyase activity
has exact synonym: hydroxymethylglutaryl coenzyme A lyase activity
has OBO namespace: molecular_function
has related synonym: 3-hydroxy-3-methylglutaryl CoA cleaving enzyme
has related synonym: hydroxymethylglutaryl coenzyme A-cleaving enzyme
id: GO:0004419
in subset: gosubset prok
type: Class
subclass of: GO_0016833

hydroxymethylglutaryl-CoA reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
has broad synonym: 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
has broad synonym: HMG-CoA reductase activity
has db xref: EC:1.1.1.34
has db xref: KEGG:R02082
has db xref: MetaCyc:1.1.1.34-RXN
has db xref: RHEA:15992
has db xref: Reactome:REACT_100813
has db xref: Reactome:REACT_103521
has db xref: Reactome:REACT_103848
has db xref: Reactome:REACT_105607
has db xref: Reactome:REACT_106886
has db xref: Reactome:REACT_109306
has db xref: Reactome:REACT_111022
has db xref: Reactome:REACT_29404
has db xref: Reactome:REACT_30181
has db xref: Reactome:REACT_80613
has db xref: Reactome:REACT_85139
has db xref: Reactome:REACT_89068
has db xref: Reactome:REACT_91015
has db xref: Reactome:REACT_91582
has db xref: Reactome:REACT_9482
has db xref: Reactome:REACT_97829
has db xref: Reactome:REACT_99024
has OBO namespace: molecular_function
id: GO:0004420
in subset: gosubset prok
type: Class
subclass of: GO_0016616

hydroxymethylglutaryl-CoA synthase activity
IAO_0000115: Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
has db xref: EC:2.3.3.10
has db xref: KEGG:R01978
has db xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
has db xref: RHEA:10191
has db xref: Reactome:REACT_101903
has db xref: Reactome:REACT_102052
has db xref: Reactome:REACT_103138
has db xref: Reactome:REACT_103948
has db xref: Reactome:REACT_109586
has db xref: Reactome:REACT_1099
has db xref: Reactome:REACT_110612
has db xref: Reactome:REACT_28230
has db xref: Reactome:REACT_30057
has db xref: Reactome:REACT_33377
has db xref: Reactome:REACT_52313
has db xref: Reactome:REACT_77956
has db xref: Reactome:REACT_78158
has db xref: Reactome:REACT_79489
has db xref: Reactome:REACT_80026
has db xref: Reactome:REACT_82694
has db xref: Reactome:REACT_83340
has db xref: Reactome:REACT_85905
has db xref: Reactome:REACT_88290
has db xref: Reactome:REACT_90273
has db xref: Reactome:REACT_91175
has db xref: Reactome:REACT_91924
has db xref: Reactome:REACT_94053
has db xref: Reactome:REACT_9443
has db xref: Reactome:REACT_95812
has db xref: Reactome:REACT_96345
has db xref: Reactome:REACT_96349
has db xref: Reactome:REACT_96512
has db xref: Reactome:REACT_97151
has db xref: Reactome:REACT_97227
has db xref: Reactome:REACT_97386
has db xref: Reactome:REACT_99476
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
has exact synonym: (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
has exact synonym: 3-hydroxy-3-methylglutaryl CoA synthetase activity
has exact synonym: 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
has exact synonym: 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
has exact synonym: 3-hydroxy-3-methylglutaryl-CoA synthase activity
has exact synonym: 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
has exact synonym: HMG-CoA synthase activity
has exact synonym: acetoacetyl coenzyme A transacetase activity
has exact synonym: acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has exact synonym: beta-hydroxy-beta-methylglutaryl-CoA synthase activity
has exact synonym: hydroxymethylglutaryl coenzyme A synthase activity
has exact synonym: hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
has OBO namespace: molecular_function
has related synonym: hydroxymethylglutaryl coenzyme A-condensing enzyme
id: GO:0004421
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.3.5.
subclass of: GO_0046912

hypoxanthine phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
has broad synonym: Transphosphoribosidase activity
has broad synonym: guanine-hypoxanthine phosphoribosyltransferase activity
has broad synonym: hypoxanthine-guanine phosphoribosyltransferase activity
has db xref: EC:2.4.2.8
has db xref: KEGG:R01132
has db xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN
has db xref: RHEA:17976
has db xref: Reactome:REACT_101452
has db xref: Reactome:REACT_102346
has db xref: Reactome:REACT_104369
has db xref: Reactome:REACT_104500
has db xref: Reactome:REACT_104785
has db xref: Reactome:REACT_110880
has db xref: Reactome:REACT_1444
has db xref: Reactome:REACT_29023
has db xref: Reactome:REACT_30909
has db xref: Reactome:REACT_31494
has db xref: Reactome:REACT_31788
has db xref: Reactome:REACT_80175
has db xref: Reactome:REACT_85512
has db xref: Reactome:REACT_89700
has db xref: Reactome:REACT_90672
has db xref: Reactome:REACT_92489
has db xref: Reactome:REACT_95149
has db xref: Reactome:REACT_99896
has exact synonym: HGPRTase activity
has exact synonym: IMP diphosphorylase activity
has exact synonym: IMP pyrophosphorylase activity
has exact synonym: IMP-GMP pyrophosphorylase activity
has exact synonym: IMP:diphosphate phospho-D-ribosyltransferase activity
has exact synonym: inosinate pyrophosphorylase activity
has exact synonym: inosine 5'-phosphate pyrophosphorylase activity
has exact synonym: inosinic acid pyrophosphorylase activity
has exact synonym: inosinic pyrophosphorylase activity
has OBO namespace: molecular_function
has related synonym: 6-hydroxypurine phosphoribosyltransferase activity
has related synonym: 6-mercaptopurine phosphoribosyltransferase activity
has related synonym: HPRT
has related synonym: purine-6-thiol phosphoribosyltransferase activity
id: GO:0004422
in subset: gosubset prok
type: Class
subclass of: GO_0016763

iduronate-2-sulfatase activity
IAO_0000115: Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.
has broad synonym: chondroitinsulfatase
has db xref: EC:3.1.6.13
has db xref: MetaCyc:3.1.6.13-RXN
has exact synonym: 2-sulfo-L-iduronate 2-sulfatase activity
has exact synonym: L-iduronate 2-sulfate sulfatase activity
has exact synonym: L-iduronate-2-sulfate 2-sulfohydrolase activity
has exact synonym: L-idurono sulfate sulfatase activity
has exact synonym: L-iduronosulfatase activity
has exact synonym: iduronate sulfatase activity
has exact synonym: iduronate sulfate sulfatase activity
has exact synonym: iduronate-2-sulfate sulfatase activity
has exact synonym: iduronate-2-sulphatase activity
has exact synonym: iduronide-2-sulfate sulfatase activity
has exact synonym: idurono-2-sulfatase activity
has exact synonym: sulfo-L-iduronate sulfatase activity
has exact synonym: sulfoiduronate sulfohydrolase activity
has OBO namespace: molecular_function
id: GO:0004423
in subset: gosubset prok
type: Class
subclass of: GO_0008484

imidazoleglycerol-phosphate dehydratase activity
IAO_0000115: Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
has db xref: EC:4.2.1.19
has db xref: KEGG:R03457
has db xref: MetaCyc:IMIDPHOSDEHYD-RXN
has db xref: RHEA:11043
has exact synonym: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity
has exact synonym: IGP dehydratase activity
has exact synonym: imidazoleglycerol phosphate dehydratase activity
has OBO namespace: molecular_function
has related synonym: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]
id: GO:0004424
in subset: gosubset prok
type: Class
subclass of: GO_0016836

indole-3-glycerol-phosphate synthase activity
IAO_0000115: Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.
has db xref: EC:4.1.1.48
has db xref: MetaCyc:IGPSYN-RXN
has db xref: RHEA:23479
has exact synonym: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)
has exact synonym: indole-3-glycerophosphate synthase activity
has exact synonym: indoleglycerol phosphate synthase activity
has exact synonym: indoleglycerol phosphate synthetase activity
has OBO namespace: molecular_function
has related synonym: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]
id: GO:0004425
in subset: gosubset prok
type: Class
subclass of: GO_0016831

inorganic diphosphatase activity
IAO_0000115: Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate.
has db xref: EC:3.6.1.1
has db xref: KEGG:R00004
has db xref: MetaCyc:INORGPYROPHOSPHAT-RXN
has db xref: RHEA:24579
has db xref: Reactome:REACT_102990
has db xref: Reactome:REACT_103050
has db xref: Reactome:REACT_106554
has db xref: Reactome:REACT_109072
has db xref: Reactome:REACT_113089
has db xref: Reactome:REACT_113725
has db xref: Reactome:REACT_114811
has db xref: Reactome:REACT_115460
has db xref: Reactome:REACT_206
has db xref: Reactome:REACT_21277
has db xref: Reactome:REACT_77713
has db xref: Reactome:REACT_80265
has db xref: Reactome:REACT_80269
has db xref: Reactome:REACT_85089
has db xref: Reactome:REACT_87198
has db xref: Reactome:REACT_87618
has db xref: Reactome:REACT_87837
has db xref: Reactome:REACT_91314
has db xref: Reactome:REACT_92435
has db xref: Reactome:REACT_95722
has exact synonym: diphosphate phosphohydrolase activity
has exact synonym: inorganic pyrophosphatase activity
has exact synonym: pyrophosphate phosphohydrolase activity
has OBO namespace: molecular_function
id: GO:0004427
in subset: gosubset prok
type: Class
subclass of: GO_0016462

inositol or phosphatidylinositol kinase activity
IAO_0000115: OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.
consider: GO:0016307
consider: GO:0019140
consider: GO:0052742
consider: GO:0052813
has exact synonym: inositol/phosphatidylinositol kinase activity
has OBO namespace: molecular_function
id: GO:0004428
type: Class
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
deprecated: true

1-phosphatidylinositol 4-kinase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
has broad synonym: PI kinase activity
has broad synonym: PI4-kinase activity
has broad synonym: PI4K
has broad synonym: PI4K-alpha activity
has broad synonym: PtdIns-4-kinase activity
has broad synonym: phosphatidylinositol 4-kinase activity
has broad synonym: phosphatidylinositol kinase (phosphorylating) activity
has broad synonym: phosphatidylinositol kinase activity
has db xref: EC:2.7.1.67
has db xref: KEGG:R03361
has db xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN
has db xref: RHEA:19880
has exact synonym: ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity
has exact synonym: PI 4-kinase activity
has OBO namespace: molecular_function
has related synonym: type II phosphatidylinositol kinase activity
id: GO:0004430
type: Class
subclass of: GO_0052742

1-phosphatidylinositol-4-phosphate kinase, class IA
IAO_0000115: OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events.
consider: GO:0016308
has OBO namespace: molecular_function
id: GO:0004432
type: Class
comment: This term was made obsolete because it is not a valid molecular function.
deprecated: true

1-phosphatidylinositol-4-phosphate kinase, class IB
IAO_0000115: OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins.
consider: GO:0016308
has OBO namespace: molecular_function
id: GO:0004433
type: Class
comment: This term was made obsolete because it is not a valid molecular function.
deprecated: true

phosphatidylinositol phospholipase C activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
has broad synonym: monophosphatidylinositol phosphodiesterase activity
has broad synonym: triphosphoinositide phosphodiesterase activity
has db xref: EC:3.1.4.11
has db xref: KEGG:R03435
has db xref: MetaCyc:3.1.4.11-RXN
has db xref: RHEA:23915
has db xref: Reactome:REACT_100549
has db xref: Reactome:REACT_101538
has db xref: Reactome:REACT_103918
has db xref: Reactome:REACT_104013
has db xref: Reactome:REACT_104384
has db xref: Reactome:REACT_105056
has db xref: Reactome:REACT_105753
has db xref: Reactome:REACT_106433
has db xref: Reactome:REACT_107694
has db xref: Reactome:REACT_108661
has db xref: Reactome:REACT_109774
has db xref: Reactome:REACT_111977
has db xref: Reactome:REACT_112016
has db xref: Reactome:REACT_112120
has db xref: Reactome:REACT_112432
has db xref: Reactome:REACT_112586
has db xref: Reactome:REACT_113026
has db xref: Reactome:REACT_113134
has db xref: Reactome:REACT_113176
has db xref: Reactome:REACT_113179
has db xref: Reactome:REACT_113201
has db xref: Reactome:REACT_113580
has db xref: Reactome:REACT_113618
has db xref: Reactome:REACT_113733
has db xref: Reactome:REACT_113827
has db xref: Reactome:REACT_113870
has db xref: Reactome:REACT_113925
has db xref: Reactome:REACT_113959
has db xref: Reactome:REACT_114034
has db xref: Reactome:REACT_114083
has db xref: Reactome:REACT_114101
has db xref: Reactome:REACT_114237
has db xref: Reactome:REACT_114264
has db xref: Reactome:REACT_114329
has db xref: Reactome:REACT_114608
has db xref: Reactome:REACT_114663
has db xref: Reactome:REACT_114783
has db xref: Reactome:REACT_115119
has db xref: Reactome:REACT_116048
has db xref: Reactome:REACT_12078
has db xref: Reactome:REACT_12585
has db xref: Reactome:REACT_15353
has db xref: Reactome:REACT_22318
has db xref: Reactome:REACT_22417
has db xref: Reactome:REACT_28616
has db xref: Reactome:REACT_31243
has db xref: Reactome:REACT_34289
has db xref: Reactome:REACT_77907
has db xref: Reactome:REACT_79438
has db xref: Reactome:REACT_80615
has db xref: Reactome:REACT_80913
has db xref: Reactome:REACT_82046
has db xref: Reactome:REACT_84690
has db xref: Reactome:REACT_86163
has db xref: Reactome:REACT_86182
has db xref: Reactome:REACT_87086
has db xref: Reactome:REACT_87142
has db xref: Reactome:REACT_87357
has db xref: Reactome:REACT_87628
has db xref: Reactome:REACT_87970
has db xref: Reactome:REACT_88756
has db xref: Reactome:REACT_88910
has db xref: Reactome:REACT_90807
has db xref: Reactome:REACT_93506
has db xref: Reactome:REACT_94845
has db xref: Reactome:REACT_97327
has db xref: Reactome:REACT_97840
has db xref: Reactome:REACT_98877
has db xref: Reactome:REACT_99371
has exact synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
has exact synonym: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
has exact synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
has exact synonym: PI-PLC activity

phosphatidylinositol diacylglycerol-lyase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.
has broad synonym: monophosphatidylinositol phosphodiesterase activity
has db xref: EC:4.6.1.13
has db xref: MetaCyc:3.1.4.10-RXN
has db xref: RHEA:17096
has exact synonym: 1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)
has exact synonym: 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
has exact synonym: 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)
has exact synonym: 1-phosphatidylinositol phosphodiesterase activity
has OBO namespace: molecular_function
id: GO:0004436
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:3.1.4.10.
subclass of: GO_0016849

inositol or phosphatidylinositol phosphatase activity
IAO_0000115: OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.
consider: GO:0034593
consider: GO:0034594
consider: GO:0052744
consider: GO:0052745
has exact synonym: inositol/phosphatidylinositol phosphatase activity
has OBO namespace: molecular_function
id: GO:0004437
type: Class
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
deprecated: true

phosphatidylinositol-3-phosphatase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
has alternative id: GO:0016315
has db xref: EC:3.1.3.64
has db xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN
has db xref: RHEA:12319
has exact synonym: 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity
has exact synonym: D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity
has exact synonym: inositol 1,3-bisphosphate phosphatase activity
has exact synonym: inositol-1,3-bisphosphate 3-phosphatase activity
has exact synonym: inositol-1,4,-bisphosphate 3-phosphatase activity
has exact synonym: inositol-polyphosphate 3-phosphatase activity
has exact synonym: phosphatidyl-3-phosphate 3-phosphohydrolase activity
has OBO namespace: molecular_function
id: GO:0004438
type: Class
comment: Note that this function includes EC:3.1.3.65.
subclass of: GO_0052744

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
has alternative id: GO:0001668
has broad synonym: phosphatidylinositol 4,5-bisphosphate phosphatase activity
has broad synonym: phosphatidylinositol-bisphosphatase activity
has broad synonym: triphosphoinositide phosphatase activity
has broad synonym: triphosphoinositide phosphomonoesterase activity
has db xref: EC:3.1.3.36
has db xref: KEGG:R04404
has db xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN
has db xref: RHEA:22767
has exact synonym: PtdIns(4,5)P(2) phosphatase activity
has exact synonym: PtdIns(4,5)P2 phosphatase activity
has exact synonym: phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity
has OBO namespace: molecular_function
id: GO:0004439
type: Class
subclass of: GO_0034593
subclass of: GO_0034595

inositol-1,4-bisphosphate 1-phosphatase activity
IAO_0000115: Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.
has broad synonym: inositol polyphosphate 1-phosphatase activity
has db xref: EC:3.1.3.57
has db xref: MetaCyc:3.1.3.57-RXN
has db xref: RHEA:15556
has exact synonym: 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity
has exact synonym: inositol-polyphosphate 1-phosphatase activity
has OBO namespace: molecular_function
id: GO:0004441
type: Class
subclass of: GO_0016312

inositol-1,4,-bisphosphate 3-phosphatase
IAO_0000115: OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate.
consider: GO:0004438
has OBO namespace: molecular_function
id: GO:0004442
type: Class
deprecated: true

inositol-1,4,-bisphosphate 4-phosphatase
IAO_0000115: OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate.
consider: GO:0016316
has OBO namespace: molecular_function
id: GO:0004443
type: Class
deprecated: true

inositol-1,4,5-trisphosphate 1-phosphatase
IAO_0000115: OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate.
consider: GO:0046030
has OBO namespace: molecular_function
id: GO:0004444
type: Class
comment: This term was made obsolete because the existence of this function has not been established.
deprecated: true

inositol-polyphosphate 5-phosphatase activity
IAO_0000115: Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
has broad synonym: L-myo-inositol 1,4,5-trisphosphate-monoesterase activity
has broad synonym: inositol 1,4,5-trisphosphate phosphatase activity
has broad synonym: inositol phosphate 5-phosphomonoesterase activity
has db xref: EC:3.1.3.56
has exact synonym: D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity
has exact synonym: Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity
has exact synonym: inositol polyphosphate-5-phosphatase activity
has exact synonym: inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity
has narrow synonym: 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity
has narrow synonym: D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity
has narrow synonym: D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity
has narrow synonym: Ins(1,4,5)P(3) 5-phosphatase activity
has narrow synonym: Ins(1,4,5)P3 5-phosphatase activity
has narrow synonym: InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity
has narrow synonym: InsP3/Ins(1,3,4,5)P4 5-phosphatase activity
has narrow synonym: inositol-1,4,5-trisphosphate 5-phosphatase activity
has narrow synonym: myo-inositol-1,4,5-trisphosphate 5-phosphatase activity
has narrow synonym: type II inositol-1,4,5-trisphosphate 5-phosphatase activity
has OBO namespace: molecular_function
has related synonym: 5PTase activity
has related synonym: inosine triphosphatase activity
has related synonym: inositol triphosphate 5-phosphomonoesterase activity
has related synonym: inositol trisphosphate phosphomonoesterase activity
has related synonym: type I inositol-polyphosphate phosphatase activity
has related synonym: type II inositol polyphosphate 5-phosphatase activity
id: GO:0004445
type: Class
comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'.
subclass of: GO_0046030

inositol-hexakisphosphate phosphatase activity
IAO_0000115: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.
has broad synonym: MIPP activity
has broad synonym: multiple inositol-polyphosphate phosphatase activity
has db xref: EC:3.1.3.62
has db xref: MetaCyc:RXN-7920
has narrow synonym: 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity
has OBO namespace: molecular_function
has related synonym: inositol tetrakisphosphate phosphomonoesterase activity
id: GO:0004446
type: Class
subclass of: GO_0052745

iodide peroxidase activity
IAO_0000115: Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O.
has db xref: EC:1.11.1.8
has db xref: MetaCyc:IODIDE-PEROXIDASE-RXN
has db xref: RHEA:23339
has exact synonym: iodide peroxidase-tyrosine iodinase activity
has exact synonym: iodide:hydrogen-peroxide oxidoreductase activity
has exact synonym: iodoperoxidase (heme type)
has exact synonym: iodotyrosine deiodase activity
has exact synonym: iodotyrosine deiodinase activity
has exact synonym: monoiodotyrosine deiodinase activity
has exact synonym: tyrosine iodinase activity
has OBO namespace: molecular_function
has related synonym: TPO activity
has related synonym: iodinase activity
has related synonym: thyroid peroxidase activity
has related synonym: thyroperoxidase activity
id: GO:0004447
type: Class
subclass of: GO_0004601

isocitrate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
has db xref: EC:1.1.1.-
has db xref: MetaCyc:ISOCITDEH-RXN
has exact synonym: IDH activity
has exact synonym: IDP activity
has exact synonym: beta-ketoglutaric-isocitric carboxylase activity
has exact synonym: isocitric acid dehydrogenase activity
has exact synonym: isocitric dehydrogenase activity
has exact synonym: oxalosuccinate carboxylase activity
has exact synonym: oxalosuccinate decarboxylase activity
has exact synonym: oxalsuccinic decarboxylase activity
has OBO namespace: molecular_function
has related synonym: IDP1
has related synonym: IDP2
has related synonym: IDP3
id: GO:0004448
in subset: gosubset prok
type: Class
subclass of: GO_0016616

isocitrate dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
has db xref: EC:1.1.1.41
has db xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN
has db xref: RHEA:23635
has db xref: Reactome:REACT_103757
has db xref: Reactome:REACT_104411
has db xref: Reactome:REACT_105047
has db xref: Reactome:REACT_1068
has db xref: Reactome:REACT_112010
has db xref: Reactome:REACT_113241
has db xref: Reactome:REACT_115988
has db xref: Reactome:REACT_33751
has db xref: Reactome:REACT_34198
has db xref: Reactome:REACT_34664
has db xref: Reactome:REACT_78963
has db xref: Reactome:REACT_81678
has db xref: Reactome:REACT_86659
has db xref: Reactome:REACT_90578
has db xref: Reactome:REACT_91953
has db xref: Reactome:REACT_98704
has exact synonym: NAD dependent isocitrate dehydrogenase activity
has exact synonym: NAD isocitrate dehydrogenase activity
has exact synonym: NAD isocitric dehydrogenase activity
has exact synonym: NAD-linked isocitrate dehydrogenase activity
has exact synonym: NAD-specific isocitrate dehydrogenase activity
has exact synonym: isocitrate dehydrogenase (NAD) activity
has exact synonym: isocitrate:NAD+ oxidoreductase (decarboxylating)
has exact synonym: nicotinamide adenine dinucleotide isocitrate dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004449
in subset: gosubset prok
type: Class
subclass of: isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+.
has db xref: EC:1.1.1.42
has db xref: MetaCyc:ISOCITDEH-RXN
has db xref: RHEA:19632
has db xref: Reactome:REACT_104086
has db xref: Reactome:REACT_104798
has db xref: Reactome:REACT_104821
has db xref: Reactome:REACT_104832
has db xref: Reactome:REACT_104911
has db xref: Reactome:REACT_106443
has db xref: Reactome:REACT_108800
has db xref: Reactome:REACT_112251
has db xref: Reactome:REACT_112495
has db xref: Reactome:REACT_113535
has db xref: Reactome:REACT_114848
has db xref: Reactome:REACT_115223
has db xref: Reactome:REACT_115270
has db xref: Reactome:REACT_16932
has db xref: Reactome:REACT_17007
has db xref: Reactome:REACT_21355
has db xref: Reactome:REACT_28361
has db xref: Reactome:REACT_31019
has db xref: Reactome:REACT_78326
has db xref: Reactome:REACT_81511
has db xref: Reactome:REACT_82608
has db xref: Reactome:REACT_83142
has db xref: Reactome:REACT_83540
has db xref: Reactome:REACT_83832
has db xref: Reactome:REACT_85281
has db xref: Reactome:REACT_85959
has db xref: Reactome:REACT_86187
has db xref: Reactome:REACT_86321
has db xref: Reactome:REACT_86533
has db xref: Reactome:REACT_87891
has db xref: Reactome:REACT_91253
has db xref: Reactome:REACT_91802
has db xref: Reactome:REACT_93164
has db xref: Reactome:REACT_94125
has db xref: Reactome:REACT_94261
has db xref: Reactome:REACT_98690
has exact synonym: NADP isocitric dehydrogenase activity
has exact synonym: NADP(+)-ICDH activity
has exact synonym: NADP(+)-IDH activity
has exact synonym: NADP(+)-linked isocitrate dehydrogenase activity
has exact synonym: NADP-dependent isocitrate dehydrogenase activity
has exact synonym: NADP-dependent isocitric dehydrogenase activity
has exact synonym: NADP-linked isocitrate dehydrogenase activity
has exact synonym: NADP-specific isocitrate dehydrogenase activity
has exact synonym: isocitrate (NADP) dehydrogenase activity
has exact synonym: isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
has exact synonym: isocitrate dehydrogenase (NADP) activity
has exact synonym: isocitrate dehydrogenase (NADP-dependent) activity
has exact synonym: isocitrate:NADP+ oxidoreductase (decarboxylating)
has OBO namespace: molecular_function
has related synonym: dual-cofactor-specific isocitrate dehydrogenase activity
has related synonym: triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity
id: GO:0004450
in subset: gosubset prok
type: Class
subclass of: isocitrate dehydrogenase activity

isocitrate lyase activity
IAO_0000115: Catalysis of the reaction: isocitrate = glyoxylate + succinate.
has db xref: EC:4.1.3.1
has db xref: KEGG:R00479
has db xref: MetaCyc:ISOCIT-CLEAV-RXN
has db xref: RHEA:13248
has exact synonym: ICL activity
has exact synonym: isocitrase activity
has exact synonym: isocitratase activity
has exact synonym: isocitrate glyoxylate-lyase (succinate-forming)
has exact synonym: isocitrate glyoxylate-lyase activity
has exact synonym: isocitritase activity
has exact synonym: threo-DS-isocitrate glyoxylate-lyase activity
has OBO namespace: molecular_function
id: GO:0004451
in subset: gosubset prok
type: Class
subclass of: GO_0016833

isopentenyl-diphosphate delta-isomerase activity
IAO_0000115: Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.
has db xref: EC:5.3.3.2
has db xref: KEGG:R01123
has db xref: MetaCyc:IPPISOM-RXN
has db xref: RHEA:23287
has db xref: Reactome:REACT_102787
has db xref: Reactome:REACT_108635
has db xref: Reactome:REACT_110091
has db xref: Reactome:REACT_34029
has db xref: Reactome:REACT_39733
has db xref: Reactome:REACT_78972
has db xref: Reactome:REACT_83548
has db xref: Reactome:REACT_84241
has db xref: Reactome:REACT_86017
has db xref: Reactome:REACT_89273
has db xref: Reactome:REACT_90239
has db xref: Reactome:REACT_91068
has db xref: Reactome:REACT_92472
has db xref: Reactome:REACT_9517
has db xref: Reactome:REACT_97232
has db xref: Reactome:REACT_98735
has db xref: Reactome:REACT_99205
has exact synonym: IPP isomerase activity
has exact synonym: isopentenyl-diphosphate D-isomerase activity
has exact synonym: isopentenyl-diphosphate delta3-delta2-isomerase activity
has exact synonym: isopentenylpyrophosphate delta-isomerase activity
has exact synonym: isopentenylpyrophosphate isomerase activity
has exact synonym: methylbutenylpyrophosphate isomerase activity
has OBO namespace: molecular_function
id: GO:0004452
in subset: gosubset prok
type: Class
subclass of: GO_0016863

juvenile-hormone esterase activity
IAO_0000115: Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.
has db xref: EC:3.1.1.59
has db xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN
has db xref: RHEA:16396
has exact synonym: JH esterase activity
has exact synonym: JH-esterase activity
has exact synonym: juvenile hormone analog esterase activity
has exact synonym: juvenile hormone carboxyesterase activity
has exact synonym: methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity
has OBO namespace: molecular_function
id: GO:0004453
type: Class
subclass of: GO_0052689

ketohexokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.
has db xref: EC:2.7.1.3
has db xref: MetaCyc:KETOHEXOKINASE-RXN
has db xref: RHEA:18148
has db xref: Reactome:REACT_101082
has db xref: Reactome:REACT_110931
has db xref: Reactome:REACT_1927
has db xref: Reactome:REACT_28411
has db xref: Reactome:REACT_82053
has db xref: Reactome:REACT_85703
has db xref: Reactome:REACT_87215
has db xref: Reactome:REACT_94196
has db xref: Reactome:REACT_95161
has db xref: Reactome:REACT_95975
has db xref: Reactome:REACT_99716
has exact synonym: ATP:D-fructose 1-phosphotransferase activity
has exact synonym: ketohexokinase (phosphorylating)
has narrow synonym: hepatic fructokinase activity
has OBO namespace: molecular_function
id: GO:0004454
in subset: gosubset prok
type: Class
subclass of: GO_0016773
subclass of: GO_0019200

ketol-acid reductoisomerase activity
IAO_0000115: Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
has db xref: EC:1.1.1.86
has db xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN
has exact synonym: (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
has exact synonym: 2-hydroxy-3-keto acid reductoisomerase activity
has exact synonym: acetohydroxy acid isomeroreductase activity
has exact synonym: acetohydroxy acid reductoisomerase activity
has exact synonym: acetolactate reductoisomerase activity
has exact synonym: alpha-keto-beta-hydroxylacyl reductoisomerase activity
has exact synonym: dihydroxyisovalerate (isomerizing) dehydrogenase activity
has exact synonym: dihydroxyisovalerate dehydrogenase (isomerizing) activity
has exact synonym: isomeroreductase activity
has exact synonym: ketol acid reductoisomerase activity
has exact synonym: reductoisomerase activity
has OBO namespace: molecular_function
id: GO:0004455
in subset: gosubset prok
type: Class
subclass of: GO_0016616

phosphogluconate dehydratase activity
IAO_0000115: Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O.
has db xref: EC:4.2.1.12
has db xref: KEGG:R02036
has db xref: MetaCyc:PGLUCONDEHYDRAT-RXN
has db xref: RHEA:17280
has exact synonym: 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
has exact synonym: 6-phospho-D-gluconate hydro-lyase activity
has exact synonym: 6-phosphogluconate dehydrase activity
has exact synonym: 6-phosphogluconate dehydratase activity
has exact synonym: 6-phosphogluconic dehydrase activity
has exact synonym: gluconate 6-phosphate dehydratase activity
has exact synonym: gluconate-6-phosphate dehydratase activity
has OBO namespace: molecular_function
id: GO:0004456
in subset: gosubset prok
type: Class
subclass of: GO_0016836

lactate dehydrogenase activity
IAO_0000115: Catalysis of the oxidation of lactate to produce pyruvate.
has db xref: RHEA:23447
has OBO namespace: molecular_function
id: GO:0004457
in subset: gosubset prok
type: Class
subclass of: GO_0016614

D-lactate dehydrogenase (cytochrome) activity
IAO_0000115: Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
has broad synonym: lactic acid dehydrogenase activity
has db xref: EC:1.1.2.4
has db xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
has exact synonym: (R)-lactate:ferricytochrome-c 2-oxidoreductase activity
has exact synonym: D-(-)-lactic cytochrome c reductase activity
has exact synonym: D-lactate (cytochrome) dehydrogenase activity
has exact synonym: D-lactate ferricytochrome c oxidoreductase activity
has exact synonym: D-lactate-cytochrome c reductase activity
has exact synonym: cytochrome-dependent D-(-)-lactate dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004458
in subset: gosubset prok
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016898

L-lactate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
has db xref: EC:1.1.1.27
has db xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN
has db xref: RHEA:23447
has db xref: Reactome:REACT_100002
has db xref: Reactome:REACT_1010
has db xref: Reactome:REACT_101688
has db xref: Reactome:REACT_106663
has db xref: Reactome:REACT_108879
has db xref: Reactome:REACT_109914
has db xref: Reactome:REACT_110161
has db xref: Reactome:REACT_112284
has db xref: Reactome:REACT_112343
has db xref: Reactome:REACT_112780
has db xref: Reactome:REACT_112887
has db xref: Reactome:REACT_113309
has db xref: Reactome:REACT_113500
has db xref: Reactome:REACT_115097
has db xref: Reactome:REACT_115372
has db xref: Reactome:REACT_115608
has db xref: Reactome:REACT_116117
has db xref: Reactome:REACT_178
has db xref: Reactome:REACT_29902
has db xref: Reactome:REACT_31172
has db xref: Reactome:REACT_31282
has db xref: Reactome:REACT_77513
has db xref: Reactome:REACT_78115
has db xref: Reactome:REACT_80242
has db xref: Reactome:REACT_81403
has db xref: Reactome:REACT_81615
has db xref: Reactome:REACT_84410
has db xref: Reactome:REACT_85236
has db xref: Reactome:REACT_87441
has db xref: Reactome:REACT_88565
has db xref: Reactome:REACT_92252
has db xref: Reactome:REACT_93008
has db xref: Reactome:REACT_95105
has db xref: Reactome:REACT_97518
has exact synonym: L-lactic acid dehydrogenase activity
has exact synonym: L-lactic dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004459
in subset: gosubset prok
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016616

L-lactate dehydrogenase (cytochrome) activity
IAO_0000115: Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
has broad synonym: lactic acid dehydrogenase activity
has db xref: EC:1.1.2.3
has db xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
has exact synonym: (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
has exact synonym: L(+)-lactate:cytochrome c oxidoreductase activity
has exact synonym: L-lactate cytochrome c oxidoreductase activity
has exact synonym: L-lactate cytochrome c reductase activity
has exact synonym: L-lactate ferricytochrome c oxidoreductase activity
has exact synonym: dehydrogenase, lactate (cytochrome)
has exact synonym: lactate dehydrogenase (cytochrome)
has exact synonym: lactic cytochrome c reductase activity
has OBO namespace: molecular_function
has related synonym: cytochrome b2
has related synonym: cytochrome b2 (flavin-free derivative of flavocytochrome b2)
has related synonym: flavocytochrome b2
id: GO:0004460
in subset: gosubset prok
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016898

lactose synthase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.
has db xref: EC:2.4.1.22
has db xref: MetaCyc:LACTOSE-SYNTHASE-RXN
has db xref: RHEA:12407
has exact synonym: UDP-galactose-glucose galactosyltransferase activity
has exact synonym: UDP-galactose:D-glucose 4-beta-D-galactotransferase activity
has exact synonym: UDPgalactose-glucose galactosyltransferase activity
has exact synonym: UDPgalactose:D-glucose 4-beta-D-galactotransferase activity
has exact synonym: lactose synthetase activity
has exact synonym: uridine diphosphogalactose-glucose galactosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004461
type: Class
subclass of: GO_0035250

lactoylglutathione lyase activity
IAO_0000115: Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
has db xref: EC:4.4.1.5
has db xref: KEGG:R02530
has db xref: MetaCyc:GLYOXI-RXN
has db xref: RHEA:19072
has exact synonym: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity
has exact synonym: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
has exact synonym: aldoketomutase activity
has exact synonym: glyoxalase I activity
has exact synonym: ketone-aldehyde mutase activity
has exact synonym: methylglyoxalase activity
has OBO namespace: molecular_function
has related synonym: glyoxylase I
id: GO:0004462
in subset: gosubset prok
type: Class
subclass of: GO_0016846

leukotriene-A4 hydrolase activity
IAO_0000115: Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
has db xref: EC:3.3.2.6
has db xref: KEGG:R03057
has db xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN
has db xref: RHEA:22327
has db xref: Reactome:REACT_107223
has db xref: Reactome:REACT_113583
has db xref: Reactome:REACT_113737
has db xref: Reactome:REACT_115125
has db xref: Reactome:REACT_115164
has db xref: Reactome:REACT_15478
has db xref: Reactome:REACT_28633
has db xref: Reactome:REACT_80031
has db xref: Reactome:REACT_82629
has db xref: Reactome:REACT_83037
has db xref: Reactome:REACT_87303
has db xref: Reactome:REACT_91502
has db xref: Reactome:REACT_92157
has db xref: Reactome:REACT_93154
has db xref: Reactome:REACT_94702
has db xref: Reactome:REACT_98948
has exact synonym: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
has exact synonym: LTA-4 hydrolase activity
has exact synonym: LTA4 hydrolase activity
has exact synonym: leukotriene A(4) hydrolase activity
has exact synonym: leukotriene A4 hydrolase activity
has OBO namespace: molecular_function
has related synonym: LTA4H
id: GO:0004463
in subset: gosubset prok
type: Class
subclass of: GO_0016803

leukotriene-C4 synthase activity
IAO_0000115: Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).
has db xref: EC:4.4.1.20
has db xref: KEGG:R03059
has db xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN
has db xref: RHEA:17620
has db xref: Reactome:REACT_104142
has db xref: Reactome:REACT_108117
has db xref: Reactome:REACT_110444
has db xref: Reactome:REACT_15413
has db xref: Reactome:REACT_29500
has db xref: Reactome:REACT_82111
has db xref: Reactome:REACT_84699
has db xref: Reactome:REACT_88206
has db xref: Reactome:REACT_95364
has db xref: Reactome:REACT_95633
has exact synonym: (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)
has exact synonym: (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
has exact synonym: LTC(4) synthase activity
has exact synonym: LTC(4) synthetase activity
has exact synonym: LTC4 synthase activity
has exact synonym: LTC4 synthetase activity
has exact synonym: leukotriene A(4):glutathione S-leukotrienyltransferase activity
has exact synonym: leukotriene A4:glutathione S-leukotrienyltransferase activity
has exact synonym: leukotriene C(4) synthetase activity
has exact synonym: leukotriene C4 synthetase activity
has exact synonym: leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
has OBO namespace: molecular_function
id: GO:0004464
type: Class
comment: Note that this function was EC:2.5.1.37.
subclass of: GO_0016846

lipoprotein lipase activity
IAO_0000115: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
has db xref: EC:3.1.1.34
has db xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN
has db xref: RHEA:12047
has db xref: Reactome:REACT_103845
has db xref: Reactome:REACT_104919
has db xref: Reactome:REACT_33675
has db xref: Reactome:REACT_6734
has db xref: Reactome:REACT_81730
has exact synonym: diacylglycerol hydrolase activity
has exact synonym: diacylglycerol lipase activity
has exact synonym: diglyceride lipase activity
has exact synonym: postheparin esterase activity
has exact synonym: postheparin lipase activity
has exact synonym: triacylglycero-protein acylhydrolase activity
has OBO namespace: molecular_function
has related synonym: clearing factor lipase activity
has related synonym: lipemia-clearing factor
id: GO:0004465
type: Class
subclass of: GO_0016298
subclass of: GO_0052689

long-chain-acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
has db xref: EC:1.3.99.13
has db xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN
has exact synonym: long-chain acyl-coenzyme A dehydrogenase activity
has exact synonym: long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity
has exact synonym: long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity
has exact synonym: palmitoyl-CoA dehydrogenase activity
has exact synonym: palmitoyl-coenzyme A dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004466
in subset: gosubset prok
type: Class
subclass of: acyl-CoA dehydrogenase activity

long-chain fatty acid-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has broad synonym: acyl-activating enzyme activity
has db xref: EC:6.2.1.3
has db xref: MetaCyc:ACYLCOASYN-RXN
has db xref: MetaCyc:PWY-5143
has db xref: Reactome:REACT_10000
has db xref: Reactome:REACT_100146
has db xref: Reactome:REACT_10020
has db xref: Reactome:REACT_10034
has db xref: Reactome:REACT_100377
has db xref: Reactome:REACT_10049
has db xref: Reactome:REACT_10064
has db xref: Reactome:REACT_10087
has db xref: Reactome:REACT_10106
has db xref: Reactome:REACT_10119
has db xref: Reactome:REACT_101550
has db xref: Reactome:REACT_102048
has db xref: Reactome:REACT_102674
has db xref: Reactome:REACT_102719
has db xref: Reactome:REACT_102779
has db xref: Reactome:REACT_103147
has db xref: Reactome:REACT_103154
has db xref: Reactome:REACT_103348
has db xref: Reactome:REACT_104228
has db xref: Reactome:REACT_104748
has db xref: Reactome:REACT_105072
has db xref: Reactome:REACT_105167
has db xref: Reactome:REACT_105842
has db xref: Reactome:REACT_106315
has db xref: Reactome:REACT_106400
has db xref: Reactome:REACT_106582
has db xref: Reactome:REACT_107010
has db xref: Reactome:REACT_107065
has db xref: Reactome:REACT_107825
has db xref: Reactome:REACT_108040
has db xref: Reactome:REACT_108152
has db xref: Reactome:REACT_108327
has db xref: Reactome:REACT_108413
has db xref: Reactome:REACT_109181
has db xref: Reactome:REACT_109281
has db xref: Reactome:REACT_109377
has db xref: Reactome:REACT_109580
has db xref: Reactome:REACT_110284
has db xref: Reactome:REACT_110400
has db xref: Reactome:REACT_110600
has db xref: Reactome:REACT_110635
has db xref: Reactome:REACT_11137
has db xref: Reactome:REACT_112002
has db xref: Reactome:REACT_112185
has db xref: Reactome:REACT_112197
has db xref: Reactome:REACT_112234
has db xref: Reactome:REACT_112314
has db xref: Reactome:REACT_112696
has db xref: Reactome:REACT_113165
has db xref: Reactome:REACT_113283
has db xref: Reactome:REACT_113402
has db xref: Reactome:REACT_113433
has db xref: Reactome:REACT_113477
has db xref: Reactome:REACT_113562
has db xref: Reactome:REACT_113604
has db xref: Reactome:REACT_114408
has db xref: Reactome:REACT_114641
has db xref: Reactome:REACT_114941
has db xref: Reactome:REACT_115449
has db xref: Reactome:REACT_115464
has db xref: Reactome:REACT_22247
has db xref: Reactome:REACT_22376
has db xref: Reactome:REACT_22410
has db xref: Reactome:REACT_28244
has db xref: Reactome:REACT_28477
has db xref: Reactome:REACT_28700
has db xref: Reactome:REACT_29173
has db xref: Reactome:REACT_30197
has db xref: Reactome:REACT_30265
has db xref: Reactome:REACT_32832
has db xref: Reactome:REACT_33155
has db xref: Reactome:REACT_33243
has db xref: Reactome:REACT_34606
has db xref: Reactome:REACT_34728
has db xref: Reactome:REACT_77878

lysine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
has db xref: EC:2.3.1.32
has db xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN
has db xref: RHEA:14420
has exact synonym: LAT activity
has exact synonym: acetyl-phosphate:L-lysine 6-N-acetyltransferase activity
has exact synonym: acetyl-phosphate:L-lysine N6-acetyltransferase activity
has exact synonym: lysine N(6)-acetyltransferase activity
has exact synonym: lysine N6-acetyltransferase activity
has exact synonym: lysine acetyltransferase activity
has OBO namespace: molecular_function
id: GO:0004468
in subset: gosubset prok
type: Class
subclass of: GO_0008080

malic enzyme activity
IAO_0000115: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
has exact synonym: pyruvic-malic carboxylase activity
has OBO namespace: molecular_function
id: GO:0004470
in subset: gosubset prok
type: Class
subclass of: GO_0016615

malate dehydrogenase (decarboxylating) activity
IAO_0000115: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate.
has broad synonym: NAD-malic enzyme activity
has db xref: EC:1.1.1.39
has db xref: MetaCyc:1.1.1.39-RXN
has db xref: RHEA:12656
has exact synonym: (S)-malate:NAD+ oxidoreductase (decarboxylating)
has OBO namespace: molecular_function
has related synonym: 'malic' enzyme
has related synonym: NAD-specific malic enzyme
id: GO:0004471
in subset: gosubset prok
type: Class
subclass of: malic enzyme activity
subclass of: GO_0016616

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
IAO_0000115: Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
has db xref: EC:1.1.1.40
has db xref: MetaCyc:MALIC-NADP-RXN
has db xref: RHEA:18256
has exact synonym: (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
has exact synonym: L-malate:NADP oxidoreductase activity
has exact synonym: NADP-malic enzyme activity
has exact synonym: NADP-specific malate dehydrogenase activity
has exact synonym: malate dehydrogenase (NADP, decarboxylating)
has exact synonym: malate dehydrogenase (decarboxylating, NADP)
has OBO namespace: molecular_function
has related synonym: 'malic' enzyme
has related synonym: NADP-linked decarboxylating malic enzyme
has related synonym: NADP-specific malic enzyme
id: GO:0004473
in subset: gosubset prok
type: Class
subclass of: malic enzyme activity
subclass of: GO_0016616

malate synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
has db xref: EC:2.3.3.9
has db xref: KEGG:R00472
has db xref: MetaCyc:MALSYN-RXN
has db xref: RHEA:18184
has exact synonym: L-malate glyoxylate-lyase (CoA-acetylating) activity
has exact synonym: acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has exact synonym: glyoxylate transacetase activity
has exact synonym: glyoxylate transacetylase activity
has exact synonym: glyoxylic transacetase activity
has exact synonym: malate synthetase activity
has exact synonym: malic synthetase activity
has OBO namespace: molecular_function
has related synonym: malate condensing enzyme activity
has related synonym: malic-condensing enzyme activity
id: GO:0004474
in subset: gosubset prok
type: Class
comment: Note that this function was formerly EC:4.1.3.2.
subclass of: GO_0046912

mannose-1-phosphate guanylyltransferase activity
IAO_0000115: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.
has db xref: EC:2.7.7.13
has db xref: KEGG:R00885
has db xref: MetaCyc:2.7.7.13-RXN
has db xref: RHEA:15232
has db xref: Reactome:REACT_22254
has db xref: Reactome:REACT_22422
has exact synonym: GTP-mannose-1-phosphate guanylyltransferase activity
has exact synonym: GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity
has exact synonym: GTP:mannose-1-phosphate guanylyltransferase activity
has exact synonym: guanosine 5'-diphospho-D-mannose pyrophosphorylase activity
has exact synonym: guanosine diphosphomannose pyrophosphorylase activity
has exact synonym: guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity
has exact synonym: mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
has OBO namespace: molecular_function
has related synonym: GDP-mannose pyrophosphorylase activity
has related synonym: PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)
id: GO:0004475
in subset: gosubset prok
type: Class
subclass of: GO_0008905

mannose-6-phosphate isomerase activity
IAO_0000115: Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
has broad synonym: phosphohexoisomerase activity
has broad synonym: phosphohexomutase activity
has db xref: EC:5.3.1.8
has db xref: MetaCyc:MANNPISOM-RXN
has db xref: RHEA:12359
has db xref: Reactome:REACT_22388
has exact synonym: D-mannose-6-phosphate aldose-ketose-isomerase activity
has exact synonym: D-mannose-6-phosphate ketol-isomerase activity
has exact synonym: mannose phosphate isomerase activity
has exact synonym: phosphomannoisomerase activity
has exact synonym: phosphomannose isomerase activity
has OBO namespace: molecular_function
id: GO:0004476
in subset: gosubset prok
type: Class
subclass of: GO_0016861

methenyltetrahydrofolate cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
has db xref: EC:3.5.4.9
has db xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN
has db xref: RHEA:23703
has db xref: Reactome:REACT_100157
has db xref: Reactome:REACT_101585
has db xref: Reactome:REACT_102491
has db xref: Reactome:REACT_103687
has db xref: Reactome:REACT_106684
has db xref: Reactome:REACT_108601
has db xref: Reactome:REACT_109212
has db xref: Reactome:REACT_110703
has db xref: Reactome:REACT_11074
has db xref: Reactome:REACT_11205
has db xref: Reactome:REACT_112952
has db xref: Reactome:REACT_114540
has db xref: Reactome:REACT_28240
has db xref: Reactome:REACT_29637
has db xref: Reactome:REACT_31039
has db xref: Reactome:REACT_32652
has db xref: Reactome:REACT_33466
has db xref: Reactome:REACT_79321
has db xref: Reactome:REACT_80741
has db xref: Reactome:REACT_82938
has db xref: Reactome:REACT_83916
has db xref: Reactome:REACT_86028
has db xref: Reactome:REACT_86775
has db xref: Reactome:REACT_89595
has db xref: Reactome:REACT_89688
has db xref: Reactome:REACT_89911
has db xref: Reactome:REACT_91311
has db xref: Reactome:REACT_93910
has exact synonym: 5,10-methenyl-THF cyclohydrolase activity
has exact synonym: 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
has exact synonym: citrovorum factor cyclodehydrase activity
has exact synonym: formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
has OBO namespace: molecular_function
id: GO:0004477
in subset: gosubset prok
type: Class
subclass of: GO_0019238

methionine adenosyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.
has db xref: EC:2.5.1.6
has db xref: MetaCyc:S-ADENMETSYN-RXN
has db xref: RHEA:21083
has db xref: Reactome:REACT_103144
has db xref: Reactome:REACT_103329
has db xref: Reactome:REACT_105520
has db xref: Reactome:REACT_115032
has db xref: Reactome:REACT_32402
has db xref: Reactome:REACT_60836
has db xref: Reactome:REACT_6819
has db xref: Reactome:REACT_77762
has db xref: Reactome:REACT_77766
has db xref: Reactome:REACT_77967
has db xref: Reactome:REACT_87465
has db xref: Reactome:REACT_91839
has db xref: Reactome:REACT_92413
has db xref: Reactome:REACT_96978
has exact synonym: ATP-methionine adenosyltransferase activity
has exact synonym: ATP:L-methionine S-adenosyltransferase activity
has exact synonym: AdoMet synthetase activity
has exact synonym: S-adenosyl-L-methionine synthetase activity
has exact synonym: S-adenosylmethionine synthase activity
has exact synonym: S-adenosylmethionine synthetase activity
has exact synonym: adenosylmethionine synthetase activity
has exact synonym: methionine S-adenosyltransferase activity
has OBO namespace: molecular_function
has related synonym: methionine-activating enzyme
id: GO:0004478
in subset: gosubset prok
type: Class
subclass of: GO_0016765

methionyl-tRNA formyltransferase activity
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.
has alternative id: GO:0001718
has alternative id: GO:0070128
has db xref: EC:2.1.2.9
has db xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN
has exact synonym: 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity
has exact synonym: N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
has exact synonym: N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
has exact synonym: formylmethionyl-transfer ribonucleic synthetase activity
has exact synonym: methionyl ribonucleic formyltransferase activity
has exact synonym: methionyl-tRNA Met formyltransferase activity
has exact synonym: methionyl-tRNA transformylase activity
has exact synonym: methionyl-transfer RNA transformylase activity
has exact synonym: methionyl-transfer ribonucleic transformylase activity
has OBO namespace: molecular_function
has related synonym: N-terminal peptidyl-methionine N-formylation
has related synonym: conversion of met-tRNAf to fmet-tRNA
has related synonym: conversion of mitochondrial met-tRNAf to fmet-tRNA
has related synonym: methionyl-transfer ribonucleate methyltransferase activity
has related synonym: mitochondrial N-terminal peptidyl-methionine N-formylation
id: GO:0004479
in subset: gosubset prok
type: Class
subclass of: GO_0016742

methylene-fatty-acyl-phospholipid synthase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.
has broad synonym: cyclopropane synthetase activity
has broad synonym: unsaturated-phospholipid methyltransferase activity
has db xref: EC:2.1.1.16
has db xref: MetaCyc:2.1.1.16-RXN
has exact synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)
has OBO namespace: molecular_function
id: GO:0004481
type: Class
subclass of: GO_0008757

mRNA (guanine-N7-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
has db xref: EC:2.1.1.56
has db xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
has db xref: Reactome:REACT_109033
has db xref: Reactome:REACT_30939
has db xref: Reactome:REACT_34170
has db xref: Reactome:REACT_404
has db xref: Reactome:REACT_84965
has db xref: Reactome:REACT_87975
has db xref: Reactome:REACT_93915
has db xref: Reactome:REACT_96650
has db xref: Reactome:REACT_97203
has db xref: Reactome:REACT_97945
has exact synonym: S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
has exact synonym: guanine-7-methyltransferase activity
has exact synonym: messenger RNA guanine 7-methyltransferase activity
has exact synonym: messenger ribonucleate guanine 7-methyltransferase activity
has OBO namespace: molecular_function
id: GO:0004482
type: Class
subclass of: GO_0008170
subclass of: GO_0008174

mRNA (nucleoside-2'-O-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
has db xref: EC:2.1.1.57
has db xref: MetaCyc:2.1.1.57-RXN
has exact synonym: S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity
has exact synonym: mRNA (adenosine-2'-O-)-methyltransferase activity
has exact synonym: messenger RNA (nucleoside-2'-)-methyltransferase activity
has exact synonym: messenger ribonucleate nucleoside 2'-methyltransferase activity
has OBO namespace: molecular_function
id: GO:0004483
in subset: gosubset prok
type: Class
subclass of: GO_0008171
subclass of: GO_0008174

mRNA guanylyltransferase activity
IAO_0000115: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.
has db xref: EC:2.7.7.50
has db xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN
has db xref: Reactome:REACT_101635
has db xref: Reactome:REACT_102473
has db xref: Reactome:REACT_103446
has db xref: Reactome:REACT_103482
has db xref: Reactome:REACT_107547
has db xref: Reactome:REACT_108251
has db xref: Reactome:REACT_110689
has db xref: Reactome:REACT_1580
has db xref: Reactome:REACT_1968
has db xref: Reactome:REACT_32228
has db xref: Reactome:REACT_36269
has db xref: Reactome:REACT_77279
has db xref: Reactome:REACT_79193
has db xref: Reactome:REACT_79495
has db xref: Reactome:REACT_80509
has db xref: Reactome:REACT_82511
has db xref: Reactome:REACT_83926
has db xref: Reactome:REACT_86486
has db xref: Reactome:REACT_86857
has db xref: Reactome:REACT_88083
has db xref: Reactome:REACT_88699
has db xref: Reactome:REACT_89040
has db xref: Reactome:REACT_90576
has db xref: Reactome:REACT_90910
has db xref: Reactome:REACT_92552
has db xref: Reactome:REACT_93206
has db xref: Reactome:REACT_93667
has db xref: Reactome:REACT_93676
has db xref: Reactome:REACT_95548
has db xref: Reactome:REACT_97427
has exact synonym: GTP--RNA guanylyltransferase activity
has exact synonym: GTP:mRNA guanylyltransferase activity
has exact synonym: messenger RNA guanylyltransferase activity
has OBO namespace: molecular_function
has related synonym: mRNA capping enzyme activity
has related synonym: protein lambda2
id: GO:0004484
type: Class
subclass of: GO_0008192

methylcrotonoyl-CoA carboxylase activity
IAO_0000115: Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
has db xref: EC:6.4.1.4
has db xref: KEGG:R04138
has db xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN
has db xref: RHEA:13592
has db xref: Reactome:REACT_101781
has db xref: Reactome:REACT_104589
has db xref: Reactome:REACT_109417
has db xref: Reactome:REACT_112537
has db xref: Reactome:REACT_1553
has db xref: Reactome:REACT_21275
has db xref: Reactome:REACT_32316
has db xref: Reactome:REACT_34548
has db xref: Reactome:REACT_75262
has db xref: Reactome:REACT_80285
has db xref: Reactome:REACT_82415
has db xref: Reactome:REACT_83431
has db xref: Reactome:REACT_90920
has db xref: Reactome:REACT_97131
has db xref: Reactome:REACT_97587
has db xref: Reactome:REACT_97960
has exact synonym: 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)
has exact synonym: beta-methylcrotonyl CoA carboxylase activity
has exact synonym: beta-methylcrotonyl coenzyme A carboxylase activity
has exact synonym: beta-methylcrotonyl-CoA carboxylase activity
has exact synonym: methylcrotonyl coenzyme A carboxylase activity
has exact synonym: methylcrotonyl-CoA carboxylase activity
has OBO namespace: molecular_function
id: GO:0004485
in subset: gosubset prok
type: Class
subclass of: GO_0016421

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
has db xref: EC:1.5.1.-
has db xref: Reactome:REACT_101357
has db xref: Reactome:REACT_104309
has db xref: Reactome:REACT_106880
has db xref: Reactome:REACT_110641
has db xref: Reactome:REACT_11187
has db xref: Reactome:REACT_11192
has db xref: Reactome:REACT_112142
has db xref: Reactome:REACT_114836
has db xref: Reactome:REACT_31299
has db xref: Reactome:REACT_32770
has db xref: Reactome:REACT_33903
has db xref: Reactome:REACT_79639
has db xref: Reactome:REACT_82275
has db xref: Reactome:REACT_82933
has db xref: Reactome:REACT_85239
has db xref: Reactome:REACT_85625
has db xref: Reactome:REACT_86748
has db xref: Reactome:REACT_89225
has db xref: Reactome:REACT_90581
has db xref: Reactome:REACT_91148
has db xref: Reactome:REACT_91334
has db xref: Reactome:REACT_91781
has db xref: Reactome:REACT_95519
has db xref: Reactome:REACT_95885
has db xref: Reactome:REACT_96601
has db xref: Reactome:REACT_96737
has db xref: Reactome:REACT_97838
has db xref: Reactome:REACT_99193
has exact synonym: 5,10-methylene-THF dehydrogenase activity
has exact synonym: N5,N10-methylenetetrahydrofolate dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004486
in subset: gosubset prok
type: Class
subclass of: GO_0016646

methylenetetrahydrofolate dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
has db xref: EC:1.5.1.15
has db xref: KEGG:R01218
has db xref: MetaCyc:1.5.1.15-RXN
has db xref: RHEA:22895
has exact synonym: 5,10-methylenetetrahydrofolate dehydrogenase activity
has exact synonym: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
has OBO namespace: molecular_function
id: GO:0004487
type: Class
subclass of: GO_0016646

methylenetetrahydrofolate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
has db xref: EC:1.5.1.5
has db xref: KEGG:R01220
has db xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN
has db xref: RHEA:22815
has exact synonym: 5,10-methylenetetrahydrofolate:NADP oxidoreductase activity
has exact synonym: 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004488
in subset: gosubset prok
type: Class
subclass of: GO_0016646

methylenetetrahydrofolate reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
has alternative id: GO:0008702
has broad synonym: 5,10-methylenetetrahydrofolate reductase activity
has broad synonym: 5,10-methylenetetrahydrofolic acid reductase activity
has broad synonym: MTHFR activity
has broad synonym: N(5),N(10)-methylenetetrahydrofolate reductase activity
has broad synonym: N(5,10)-methylenetetrahydrofolate reductase activity
has broad synonym: methylenetetrahydrofolate reductase activity
has broad synonym: methylenetetrahydrofolic acid reductase activity
has db xref: EC:1.5.1.20
has db xref: MetaCyc:1.5.1.20-RXN
has db xref: RHEA:19820
has db xref: RHEA:19825
has db xref: Reactome:REACT_100929
has db xref: Reactome:REACT_102712
has db xref: Reactome:REACT_106752
has db xref: Reactome:REACT_106770
has db xref: Reactome:REACT_109034
has db xref: Reactome:REACT_110093
has db xref: Reactome:REACT_110152
has db xref: Reactome:REACT_11102
has db xref: Reactome:REACT_29352
has db xref: Reactome:REACT_30478
has db xref: Reactome:REACT_33585
has db xref: Reactome:REACT_78371
has db xref: Reactome:REACT_96333
has db xref: Reactome:REACT_97871
has db xref: Reactome:REACT_98681
has exact synonym: 5,10-CH(2)-H(4)folate reductase activity
has exact synonym: 5,10-CH2-H4folate reductase activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (FADH) activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (FADH2) activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (NADPH) activity
has exact synonym: 5,10-methylenetetrahydropteroylglutamate reductase activity
has exact synonym: 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD+ oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NADP+ oxidoreductase activity
has exact synonym: N5,10-methylenetetrahydrofolate reductase activity
has exact synonym: N5,N10-methylenetetrahydrofolate reductase activity
has exact synonym: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
has exact synonym: methylenetetrahydrofolate reductase (NADPH(2)) activity
has exact synonym: methylenetetrahydrofolate reductase (NADPH2)
has OBO namespace: molecular_function
has related synonym: 1.7.99.5
has related synonym: 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
has related synonym: MetF
has related synonym: methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
has related synonym: methylenetetrahydrofolate reductase [NAD(P)H]
id: GO:0004489
in subset: gosubset prok
type: Class
comment: Includes EC 1.7.99.5.
subclass of: GO_0016646

methylglutaconyl-CoA hydratase activity
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.
has db xref: EC:4.2.1.18
has db xref: KEGG:R02085
has db xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN
has db xref: RHEA:21539
has db xref: Reactome:REACT_101172
has db xref: Reactome:REACT_101430
has db xref: Reactome:REACT_104594
has db xref: Reactome:REACT_106638
has db xref: Reactome:REACT_114406
has db xref: Reactome:REACT_1157
has db xref: Reactome:REACT_77810
has db xref: Reactome:REACT_79310
has db xref: Reactome:REACT_83854
has db xref: Reactome:REACT_83970
has db xref: Reactome:REACT_89339
has db xref: Reactome:REACT_91926
has db xref: Reactome:REACT_93670
has db xref: Reactome:REACT_96751
has db xref: Reactome:REACT_97337
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity
has exact synonym: 3-methylglutaconyl CoA hydratase activity
has exact synonym: methylglutaconase activity
has exact synonym: methylglutaconyl coenzyme A hydratase activity
has OBO namespace: molecular_function
id: GO:0004490
in subset: gosubset prok
type: Class
subclass of: GO_0016836

methylmalonate-semialdehyde dehydrogenase (acylating) activity
IAO_0000115: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
has db xref: EC:1.2.1.27
has db xref: MetaCyc:1.2.1.27-RXN
has db xref: RHEA:20807
has db xref: Reactome:REACT_100756
has db xref: Reactome:REACT_101467
has db xref: Reactome:REACT_101605
has db xref: Reactome:REACT_103353
has db xref: Reactome:REACT_104811
has db xref: Reactome:REACT_1077
has db xref: Reactome:REACT_28561
has db xref: Reactome:REACT_30813
has db xref: Reactome:REACT_32679
has db xref: Reactome:REACT_81708
has db xref: Reactome:REACT_84411
has db xref: Reactome:REACT_84866
has db xref: Reactome:REACT_86537
has db xref: Reactome:REACT_89741
has db xref: Reactome:REACT_95710
has db xref: Reactome:REACT_99224
has exact synonym: 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
has exact synonym: MMSA dehydrogenase activity
has exact synonym: MSDH activity
has OBO namespace: molecular_function
id: GO:0004491
in subset: gosubset prok
type: Class
subclass of: GO_0016620

methylmalonyl-CoA decarboxylase activity
IAO_0000115: Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2.
has db xref: EC:4.1.1.41
has db xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN
has db xref: RHEA:21399
has exact synonym: (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity
has exact synonym: (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
has exact synonym: (S)-methylmalonyl-CoA carboxy-lyase activity
has exact synonym: methylmalonyl-coenzyme A decarboxylase activity
has OBO namespace: molecular_function
id: GO:0004492
in subset: gosubset prok
type: Class
subclass of: GO_0016831

methylmalonyl-CoA epimerase activity
IAO_0000115: Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
has db xref: EC:5.1.99.1
has db xref: KEGG:R02765
has db xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN
has db xref: RHEA:20556
has db xref: Reactome:REACT_100697
has db xref: Reactome:REACT_102795
has db xref: Reactome:REACT_104215
has db xref: Reactome:REACT_104256
has db xref: Reactome:REACT_1909
has db xref: Reactome:REACT_32244
has db xref: Reactome:REACT_32925
has db xref: Reactome:REACT_62113
has db xref: Reactome:REACT_84891
has db xref: Reactome:REACT_86324
has db xref: Reactome:REACT_95035
has db xref: Reactome:REACT_95506
has db xref: Reactome:REACT_96525
has exact synonym: 2-methyl-3-oxopropanoyl-CoA 2-epimerase activity
has exact synonym: DL-methylmalonyl-CoA racemase activity
has exact synonym: methylmalonyl coenzyme A racemase activity
has exact synonym: methylmalonyl-CoA 2-epimerase activity
has exact synonym: methylmalonyl-CoA racemase activity
has OBO namespace: molecular_function
id: GO:0004493
in subset: gosubset prok
type: Class
subclass of: GO_0016854

methylmalonyl-CoA mutase activity
IAO_0000115: Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.
has db xref: EC:5.4.99.2
has db xref: KEGG:R00833
has db xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN
has db xref: RHEA:22891
has db xref: Reactome:REACT_110753
has db xref: Reactome:REACT_114493
has db xref: Reactome:REACT_19
has db xref: Reactome:REACT_28603
has db xref: Reactome:REACT_30850
has db xref: Reactome:REACT_32125
has db xref: Reactome:REACT_33463
has db xref: Reactome:REACT_35053
has db xref: Reactome:REACT_86041
has db xref: Reactome:REACT_86718
has db xref: Reactome:REACT_87467
has db xref: Reactome:REACT_95870
has db xref: Reactome:REACT_97766
has db xref: Reactome:REACT_98331
has db xref: UM-BBD_reactionID:r0922
has exact synonym: (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity
has exact synonym: (R)-methylmalonyl-CoA CoA-carbonylmutase activity
has exact synonym: (S)-methylmalonyl-CoA mutase activity
has exact synonym: methylmalonyl coenzyme A carbonylmutase activity
has exact synonym: methylmalonyl coenzyme A mutase activity
has exact synonym: methylmalonyl-CoA CoA-carbonyl mutase activity
has OBO namespace: molecular_function
id: GO:0004494
in subset: gosubset prok
type: Class
subclass of: GO_0016866

mevaldate reductase activity
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor.
has db xref: EC:1.1.1.-
has OBO namespace: molecular_function
id: GO:0004495
type: Class
subclass of: GO_0016616

mevalonate kinase activity
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+).
has db xref: EC:2.7.1.36
has db xref: KEGG:R02245
has db xref: MetaCyc:MEVALONATE-KINASE-RXN
has db xref: RHEA:17068
has db xref: Reactome:REACT_101004
has db xref: Reactome:REACT_101608
has db xref: Reactome:REACT_102374
has db xref: Reactome:REACT_104390
has db xref: Reactome:REACT_105718
has db xref: Reactome:REACT_107959
has db xref: Reactome:REACT_110994
has db xref: Reactome:REACT_29025
has db xref: Reactome:REACT_30351
has db xref: Reactome:REACT_33985
has db xref: Reactome:REACT_78740
has db xref: Reactome:REACT_80823
has db xref: Reactome:REACT_81000
has db xref: Reactome:REACT_87306
has db xref: Reactome:REACT_9448
has db xref: Reactome:REACT_95202
has db xref: Reactome:REACT_98858
has exact synonym: ATP:(R)-mevalonate 5-phosphotransferase activity
has exact synonym: ATP:mevalonate 5-phosphotransferase activity
has exact synonym: MVA kinase activity
has exact synonym: mevalonate 5-phosphotransferase activity
has exact synonym: mevalonate kinase (phosphorylating)
has exact synonym: mevalonate phosphokinase activity
has exact synonym: mevalonic acid kinase activity
has exact synonym: mevalonic kinase activity
has OBO namespace: molecular_function
id: GO:0004496
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

monooxygenase activity
IAO_0000115: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
has db xref: Reactome:REACT_100875
has db xref: Reactome:REACT_101711
has db xref: Reactome:REACT_106539
has db xref: Reactome:REACT_106973
has db xref: Reactome:REACT_107936
has db xref: Reactome:REACT_109390
has db xref: Reactome:REACT_110926
has db xref: Reactome:REACT_113028
has db xref: Reactome:REACT_115238
has db xref: Reactome:REACT_13511
has db xref: Reactome:REACT_13592
has db xref: Reactome:REACT_13740
has db xref: Reactome:REACT_13821
has db xref: Reactome:REACT_30553
has db xref: Reactome:REACT_34685
has db xref: Reactome:REACT_78030
has db xref: Reactome:REACT_79048
has db xref: Reactome:REACT_80846
has db xref: Reactome:REACT_82079
has db xref: Reactome:REACT_84097
has db xref: Reactome:REACT_84242
has db xref: Reactome:REACT_86917
has db xref: Reactome:REACT_88779
has db xref: Reactome:REACT_90320
has db xref: Reactome:REACT_90960
has db xref: Reactome:REACT_90990
has db xref: Reactome:REACT_92968
has db xref: Reactome:REACT_95195
has db xref: Reactome:REACT_96655
has OBO namespace: molecular_function
has related synonym: hydroxylase activity
id: GO:0004497
in subset: goslim pir
in subset: gosubset prok
type: Class
subclass of: GO_0016491

calcidiol 1-monooxygenase activity
IAO_0000115: Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
has db xref: EC:1.14.13.13
has db xref: KEGG:R03610
has db xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
has db xref: RHEA:20576
has db xref: Reactome:REACT_102929
has db xref: Reactome:REACT_106826
has db xref: Reactome:REACT_110331
has db xref: Reactome:REACT_13628
has db xref: Reactome:REACT_83168
has db xref: Reactome:REACT_84663
has db xref: Reactome:REACT_93300
has exact synonym: 25-OHD-1 alpha-hydroxylase activity
has exact synonym: 25-hydroxy D3-1alpha-hydroxylase activity
has exact synonym: 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol 1-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol 1-monooxygenase activity
has exact synonym: 25-hydroxycholecalciferol 1alpha-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol-1-hydroxylase activity
has exact synonym: 25-hydroxyvitamin D-1 alpha hydroxylase activity
has exact synonym: 25-hydroxyvitamin D3 1alpha-hydroxylase activity
has exact synonym: calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
has narrow synonym: cytochrome P450 CYP27B
has OBO namespace: molecular_function
has related synonym: 1-hydroxylase-25-hydroxyvitamin D3 activity
id: GO:0004498
type: Class
subclass of: GO_0016709

N,N-dimethylaniline monooxygenase activity
IAO_0000115: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
has alternative id: GO:0047076
has broad synonym: flavin-containing monooxygenase activity
has db xref: EC:1.14.13.8
has db xref: MetaCyc:1.14.13.8-RXN
has db xref: RHEA:24471
has db xref: Reactome:REACT_101564
has db xref: Reactome:REACT_105482
has db xref: Reactome:REACT_108626
has db xref: Reactome:REACT_109888
has db xref: Reactome:REACT_110026
has db xref: Reactome:REACT_110579
has db xref: Reactome:REACT_113438
has db xref: Reactome:REACT_114014
has db xref: Reactome:REACT_114556
has db xref: Reactome:REACT_13805
has db xref: Reactome:REACT_236
has db xref: Reactome:REACT_45115
has db xref: Reactome:REACT_80104
has db xref: Reactome:REACT_80941
has db xref: Reactome:REACT_84504
has db xref: Reactome:REACT_87365
has db xref: Reactome:REACT_91809
has db xref: Reactome:REACT_95881
has db xref: Reactome:REACT_97774
has db xref: Reactome:REACT_99402
has exact synonym: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity
has exact synonym: DMA oxidase activity
has exact synonym: N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
has exact synonym: dimethylaniline N-oxidase activity
has exact synonym: dimethylaniline monooxygenase (N-oxide-forming) activity
has exact synonym: dimethylaniline oxidase activity
has exact synonym: methylphenyltetrahydropyridine N-monooxygenase activity
has OBO namespace: molecular_function
has related synonym: FAD-containing monooxygenase activity
has related synonym: FMO activity
has related synonym: FMO-I
has related synonym: FMO-II
has related synonym: FMO1
has related synonym: FMO2
has related synonym: FMO3
has related synonym: FMO4
has related synonym: FMO5
has related synonym: Ziegler's enzyme
has related synonym: flavin mixed function oxidase activity
has related synonym: flavin monooxygenase activity
has related synonym: mixed-function amine oxidase activity
id: GO:0004499
in subset: gosubset prok
type: Class
subclass of: GO_0016709

dopamine beta-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O.
has db xref: EC:1.14.17.1
has db xref: KEGG:R02535
has db xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN
has db xref: RHEA:19120
has db xref: Reactome:REACT_105580
has db xref: Reactome:REACT_106750
has db xref: Reactome:REACT_15372
has db xref: Reactome:REACT_28248
has db xref: Reactome:REACT_29465
has db xref: Reactome:REACT_32682
has db xref: Reactome:REACT_79735
has db xref: Reactome:REACT_80521
has db xref: Reactome:REACT_80863
has db xref: Reactome:REACT_89497
has db xref: Reactome:REACT_92696
has db xref: Reactome:REACT_98351
has exact synonym: (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity
has exact synonym: 3,4-dihydroxyphenethylamine beta-oxidase activity
has exact synonym: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
has exact synonym: 4-(2-aminoethyl)pyrocatechol beta-oxidase activity
has exact synonym: dopa beta-hydroxylase activity
has exact synonym: dopamine b-hydroxylase activity
has exact synonym: dopamine beta-hydroxylase activity
has exact synonym: dopamine beta-oxidase activity
has exact synonym: dopamine hydroxylase activity
has exact synonym: dopamine-B-hydroxylase activity
has exact synonym: oxygenase, dopamine beta-mono-
has exact synonym: phenylamine beta-hydroxylase activity
has OBO namespace: molecular_function
has related synonym: MDBH (membrane-associated dopamine beta-monooxygenase)
has related synonym: SDBH (soluble dopamine beta-monooxygenase)
id: GO:0004500
in subset: gosubset prok
type: Class
subclass of: GO_0016715

ecdysone 20-monooxygenase activity
IAO_0000115: Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O.
has broad synonym: ecdysone modification
has db xref: EC:1.14.99.22
has db xref: KEGG:R02374
has db xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN
has db xref: RHEA:14024
has exact synonym: alpha-ecdysone C-20 hydroxylase activity
has exact synonym: ecdysone 20-hydroxylase activity
has exact synonym: ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)
has OBO namespace: molecular_function
id: GO:0004501
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

kynurenine 3-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).
has db xref: EC:1.14.13.9
has db xref: KEGG:R01960
has db xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN
has db xref: RHEA:20548
has db xref: Reactome:REACT_100337
has db xref: Reactome:REACT_100740
has db xref: Reactome:REACT_108549
has db xref: Reactome:REACT_109130
has db xref: Reactome:REACT_79840
has db xref: Reactome:REACT_79885
has db xref: Reactome:REACT_82021
has db xref: Reactome:REACT_84641
has db xref: Reactome:REACT_86351
has db xref: Reactome:REACT_90028
has db xref: Reactome:REACT_927
has db xref: Reactome:REACT_96923
has db xref: Reactome:REACT_98896
has exact synonym: L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
has exact synonym: L-kynurenine-3-hydroxylase activity
has exact synonym: kynurenine 3-hydroxylase activity
has exact synonym: kynurenine hydroxylase activity
has OBO namespace: molecular_function
id: GO:0004502
in subset: gosubset prok
type: Class
subclass of: GO_0016709

monophenol monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
has broad synonym: phenol oxidase activity
has broad synonym: phenolase activity
has broad synonym: pyrocatechol oxidase
has db xref: EC:1.14.18.1
has db xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN
has db xref: RHEA:18120
has exact synonym: L-tyrosine monooxygenase activity
has exact synonym: N-acetyl-6-hydroxytryptophan oxidase activity
has exact synonym: monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity
has exact synonym: monophenol monooxidase activity
has exact synonym: monophenol oxidase activity
has exact synonym: monophenol oxygenase
has exact synonym: monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity
has exact synonym: monophenol,L-dopa:oxygen oxidoreductase activity
has exact synonym: monophenolase activity
has exact synonym: polyaromatic oxidase activity
has exact synonym: polyphenolase activity
has exact synonym: tyrosinase activity
has exact synonym: tyrosine-dopa oxidase activity
has OBO namespace: molecular_function
has related synonym: catecholase
has related synonym: chlorogenic acid oxidase activity
has related synonym: chlorogenic oxidase activity
has related synonym: cresolase activity
has related synonym: dopa oxidase
has related synonym: o-diphenol oxidase activity
has related synonym: o-diphenol oxidoreductase
has related synonym: o-diphenol:O2 oxidoreductase activity
has related synonym: o-diphenol:oxygen oxidoreductase
has related synonym: prophenol oxidase activity
has related synonym: prophenoloxidase activity
id: GO:0004503
in subset: gosubset prok
type: Class
comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children.
subclass of: GO_0016716

peptidylglycine monooxygenase activity
IAO_0000115: Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.
has db xref: EC:1.14.17.3
has db xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN
has exact synonym: PAM activity
has exact synonym: peptide alpha-amide synthase activity
has exact synonym: peptide-alpha-amide synthetase activity
has exact synonym: peptidyl alpha-amidating enzyme activity
has exact synonym: peptidylglycine 2-hydroxylase activity
has exact synonym: peptidylglycine alpha-amidating monooxygenase activity
has exact synonym: peptidylglycine alpha-hydroxylase activity
has exact synonym: peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
has exact synonym: synthase, peptide alpha-amide
has OBO namespace: molecular_function
has related synonym: PAM-A
has related synonym: PAM-B
has related synonym: peptide alpha-amidating enzyme
id: GO:0004504
in subset: gosubset prok
type: Class
subclass of: GO_0016715

phenylalanine 4-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
has db xref: EC:1.14.16.1
has db xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN
has db xref: RHEA:20276
has db xref: Reactome:REACT_104236
has db xref: Reactome:REACT_107202
has db xref: Reactome:REACT_2
has db xref: Reactome:REACT_32661
has db xref: Reactome:REACT_33652
has db xref: Reactome:REACT_78419
has db xref: Reactome:REACT_82050
has db xref: Reactome:REACT_89849
has db xref: Reactome:REACT_90357
has db xref: Reactome:REACT_96148
has db xref: Reactome:REACT_96746
has db xref: Reactome:REACT_99314
has db xref: Reactome:REACT_99414
has exact synonym: L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
has exact synonym: PAH activity
has exact synonym: phenylalaninase activity
has exact synonym: phenylalanine 4-hydroxylase activity
has exact synonym: phenylalanine hydroxylase activity
has OBO namespace: molecular_function
id: GO:0004505
in subset: gosubset prok
type: Class
subclass of: GO_0016714

squalene monooxygenase activity
IAO_0000115: Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
has db xref: EC:1.14.13.132
has db xref: KEGG:R02874
has db xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN
has db xref: RHEA:25285
has db xref: Reactome:REACT_100198
has db xref: Reactome:REACT_103513
has db xref: Reactome:REACT_31775
has db xref: Reactome:REACT_32861
has db xref: Reactome:REACT_34517
has db xref: Reactome:REACT_61044
has db xref: Reactome:REACT_77573
has db xref: Reactome:REACT_80341
has db xref: Reactome:REACT_80464
has db xref: Reactome:REACT_80663
has db xref: Reactome:REACT_90369
has db xref: Reactome:REACT_93218
has db xref: Reactome:REACT_9420
has db xref: Reactome:REACT_96471
has db xref: Reactome:REACT_99719
has exact synonym: squalene 2,3-oxidocyclase activity
has exact synonym: squalene epoxidase activity
has exact synonym: squalene hydroxylase activity
has exact synonym: squalene oxydocyclase activity
has exact synonym: squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
has exact synonym: squalene-2,3-epoxidase activity
has exact synonym: squalene-2,3-epoxide cyclase activity
has OBO namespace: molecular_function
id: GO:0004506
type: Class
subclass of: GO_0016709

steroid 11-beta-monooxygenase activity
IAO_0000115: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
has db xref: EC:1.14.15.4
has db xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN
has db xref: Reactome:REACT_10037
has db xref: Reactome:REACT_100776
has db xref: Reactome:REACT_10117
has db xref: Reactome:REACT_102518
has db xref: Reactome:REACT_104959
has db xref: Reactome:REACT_109791
has db xref: Reactome:REACT_13700
has db xref: Reactome:REACT_32819
has db xref: Reactome:REACT_33302
has db xref: Reactome:REACT_78151
has db xref: Reactome:REACT_89955
has db xref: Reactome:REACT_93332
has db xref: Reactome:REACT_96419
has exact synonym: oxygenase, steroid 11beta -mono-
has exact synonym: steroid 11-beta-hydroxylase activity
has exact synonym: steroid 11-beta/18-hydroxylase activity
has exact synonym: steroid 11beta-hydroxylase activity
has exact synonym: steroid 11beta-monooxygenase activity
has exact synonym: steroid 11beta/18-hydroxylase activity
has exact synonym: steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
has narrow synonym: cytochrome P450 CYP11B1
has narrow synonym: cytochrome P450 CYP11B2
has narrow synonym: cytochrome p450 XIB1 activity
has OBO namespace: molecular_function
id: GO:0004507
type: Class
subclass of: GO_0008395
subclass of: GO_0016713

steroid 17-alpha-monooxygenase activity
IAO_0000115: Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
has db xref: EC:1.14.99.9
has db xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
has db xref: Reactome:REACT_10013
has db xref: Reactome:REACT_10026
has db xref: Reactome:REACT_100552
has db xref: Reactome:REACT_10116
has db xref: Reactome:REACT_101338
has db xref: Reactome:REACT_102153
has db xref: Reactome:REACT_103760
has db xref: Reactome:REACT_112434
has db xref: Reactome:REACT_113135
has db xref: Reactome:REACT_113443
has db xref: Reactome:REACT_114963
has db xref: Reactome:REACT_28596
has db xref: Reactome:REACT_29409
has db xref: Reactome:REACT_33249
has db xref: Reactome:REACT_33293
has db xref: Reactome:REACT_34716
has db xref: Reactome:REACT_78029
has db xref: Reactome:REACT_78073
has db xref: Reactome:REACT_78525
has db xref: Reactome:REACT_80011
has db xref: Reactome:REACT_80170
has db xref: Reactome:REACT_80368
has db xref: Reactome:REACT_80594
has db xref: Reactome:REACT_81577
has db xref: Reactome:REACT_82145
has db xref: Reactome:REACT_82553
has db xref: Reactome:REACT_82875
has db xref: Reactome:REACT_83833
has db xref: Reactome:REACT_85094
has db xref: Reactome:REACT_85131
has db xref: Reactome:REACT_85525
has db xref: Reactome:REACT_85752
has db xref: Reactome:REACT_88873
has db xref: Reactome:REACT_90551
has db xref: Reactome:REACT_90696
has db xref: Reactome:REACT_95449
has db xref: Reactome:REACT_95861
has db xref: Reactome:REACT_98312
has db xref: Reactome:REACT_98314
has db xref: Reactome:REACT_9993
has exact synonym: 17alpha-hydroxylase-C17,20 lyase activity
has exact synonym: steroid 17-alpha-hydroxylase activity
has exact synonym: steroid 17-alpha-hydroxylase-C17-20 lyase activity
has exact synonym: steroid 17-alpha-hydroxylase/17,20 lyase activity
has exact synonym: steroid 17alpha-hydroxylase activity
has exact synonym: steroid 17alpha-monooxygenase activity
has exact synonym: steroid 17alphahydroxylase/17,20 lyase activity
has exact synonym: steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
has narrow synonym: cytochrome P450 CYP17
has narrow synonym: cytochrome p450 XVIIA1 activity
has OBO namespace: molecular_function
has related synonym: cytochrome P-450 (P-45017alpha,lyase)
has related synonym: cytochrome P45017alpha
id: GO:0004508
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

steroid 21-monooxygenase activity
IAO_0000115: Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
has db xref: EC:1.14.99.10
has db xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN
has db xref: Reactome:REACT_10032
has db xref: Reactome:REACT_9996
has exact synonym: 21-hydroxylase activity
has exact synonym: steroid 21-hydroxylase activity
has exact synonym: steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
has narrow synonym: cytochrome P450 CYP21A1
has narrow synonym: cytochrome p450 XXIA1 activity
has OBO namespace: molecular_function
id: GO:0004509
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

tryptophan 5-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.
has db xref: EC:1.14.16.4
has db xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN
has db xref: RHEA:16712
has db xref: Reactome:REACT_100975
has db xref: Reactome:REACT_104965
has db xref: Reactome:REACT_105680
has db xref: Reactome:REACT_106890
has db xref: Reactome:REACT_110501
has db xref: Reactome:REACT_112261
has db xref: Reactome:REACT_15352
has db xref: Reactome:REACT_29220
has db xref: Reactome:REACT_29619
has db xref: Reactome:REACT_34802
has db xref: Reactome:REACT_81276
has db xref: Reactome:REACT_89753
has db xref: Reactome:REACT_99397
has exact synonym: L-tryptophan hydroxylase activity
has exact synonym: L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
has exact synonym: indoleacetic acid-5-hydroxylase activity
has exact synonym: tryptophan 5-hydroxylase activity
has exact synonym: tryptophan hydroxylase activity
has OBO namespace: molecular_function
id: GO:0004510
type: Class
subclass of: GO_0016714

tyrosine 3-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.
has db xref: EC:1.14.16.2
has db xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN
has db xref: RHEA:18204
has db xref: Reactome:REACT_100148
has db xref: Reactome:REACT_100386
has db xref: Reactome:REACT_109224
has db xref: Reactome:REACT_110490
has db xref: Reactome:REACT_114697
has db xref: Reactome:REACT_15366
has db xref: Reactome:REACT_30893
has db xref: Reactome:REACT_31782
has db xref: Reactome:REACT_86771
has db xref: Reactome:REACT_92333
has db xref: Reactome:REACT_93744
has db xref: Reactome:REACT_98531
has exact synonym: L-tyrosine hydroxylase activity
has exact synonym: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
has exact synonym: tyrosine 3-hydroxylase activity
has exact synonym: tyrosine hydroxylase activity
has OBO namespace: molecular_function
id: GO:0004511
type: Class
subclass of: GO_0016714

inositol-3-phosphate synthase activity
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
has db xref: EC:5.5.1.4
has db xref: KEGG:R07324
has db xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
has db xref: RHEA:10719
has db xref: Reactome:REACT_27308
has exact synonym: 1L-myo-inositol-1-phosphate lyase (isomerizing)
has exact synonym: D-glucose 6-phosphate cycloaldolase activity
has exact synonym: glucocycloaldolase activity
has exact synonym: glucose 6-phosphate cyclase activity
has exact synonym: glucose-6-phosphate inositol monophosphate cycloaldolase activity
has exact synonym: inositol 1-phosphate synthatase activity
has exact synonym: inositol 1-phosphate synthetase activity
has exact synonym: myo-inositol-1-phosphate synthase activity
has OBO namespace: molecular_function
id: GO:0004512
in subset: gosubset prok
type: Class
subclass of: GO_0016872

neolactotetraosylceramide alpha-2,3-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide.
has db xref: EC:2.4.99.10
has db xref: MetaCyc:2.4.99.10-RXN
has exact synonym: CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity
has exact synonym: cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity
has OBO namespace: molecular_function
has related synonym: SAT-3
has related synonym: sialyltransferase 3
id: GO:0004513
type: Class
subclass of: GO_0008373

nicotinate-nucleotide diphosphorylase (carboxylating) activity
IAO_0000115: Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate.
has db xref: EC:2.4.2.19
has db xref: KEGG:R03348
has db xref: MetaCyc:QUINOPRIBOTRANS-RXN
has db xref: RHEA:12736
has db xref: Reactome:REACT_103381
has db xref: Reactome:REACT_105632
has db xref: Reactome:REACT_11092
has db xref: Reactome:REACT_28295
has db xref: Reactome:REACT_29883
has db xref: Reactome:REACT_31306
has db xref: Reactome:REACT_85574
has db xref: Reactome:REACT_86011
has db xref: Reactome:REACT_90651
has db xref: Reactome:REACT_90824
has db xref: Reactome:REACT_90894
has db xref: Reactome:REACT_91005
has db xref: Reactome:REACT_91028
has exact synonym: NAD pyrophosphorylase activity
has exact synonym: QAPRTase activity
has exact synonym: nicotinate mononucleotide pyrophosphorylase (carboxylating)
has exact synonym: nicotinate-nucleotide pyrophosphorylase (carboxylating) activity
has exact synonym: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
has exact synonym: quinolinate phosphoribosyltransferase (decarboxylating) activity
has exact synonym: quinolinic acid phosphoribosyltransferase activity
has exact synonym: quinolinic phosphoribosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004514
in subset: gosubset prok
type: Class
subclass of: GO_0016763

nicotinate-nucleotide adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.
has db xref: EC:2.7.7.18
has db xref: MetaCyc:NICONUCADENYLYLTRAN-RXN
has db xref: RHEA:22863
has exact synonym: ATP:nicotinate-nucleotide adenylyltransferase activity
has exact synonym: ATP:nicotinate-ribonucleotide adenylyltransferase activity
has exact synonym: NaMN-ATase activity
has exact synonym: deamido-NAD(+) diphosphorylase activity
has exact synonym: deamido-NAD(+) pyrophosphorylase activity
has exact synonym: deamido-NAD+ pyrophosphorylase activity
has exact synonym: deamidonicotinamide adenine dinucleotide pyrophosphorylase activity
has exact synonym: nicotinate mononucleotide adenylyltransferase activity
has narrow synonym: nicotinic acid mononucleotide adenylyltransferase
has OBO namespace: molecular_function
id: GO:0004515
in subset: gosubset prok
type: Class
subclass of: GO_0070566

nicotinate phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
has db xref: EC:2.4.2.11
has db xref: KEGG:R01724
has db xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN
has db xref: RHEA:13396
has db xref: Reactome:REACT_102849
has db xref: Reactome:REACT_107445
has db xref: Reactome:REACT_11132
has db xref: Reactome:REACT_30177
has db xref: Reactome:REACT_33592
has db xref: Reactome:REACT_78679
has db xref: Reactome:REACT_79312
has db xref: Reactome:REACT_79471
has db xref: Reactome:REACT_79952
has db xref: Reactome:REACT_82193
has db xref: Reactome:REACT_82687
has db xref: Reactome:REACT_83088
has db xref: Reactome:REACT_92507
has db xref: Reactome:REACT_93007
has db xref: Reactome:REACT_93585
has db xref: Reactome:REACT_96814
has exact synonym: niacin ribonucleotidase activity
has exact synonym: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
has exact synonym: nicotinic acid mononucleotide glycohydrolase activity
has exact synonym: nicotinic acid mononucleotide pyrophosphorylase activity
has exact synonym: nicotinic acid phosphoribosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004516
in subset: gosubset prok
type: Class
subclass of: GO_0016763

nitric-oxide synthase activity
IAO_0000115: Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
has db xref: EC:1.14.13.39
has db xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
has db xref: RHEA:24668
has db xref: Reactome:REACT_100132
has db xref: Reactome:REACT_105423
has db xref: Reactome:REACT_113518
has db xref: Reactome:REACT_12443
has db xref: Reactome:REACT_23872
has db xref: Reactome:REACT_29232
has db xref: Reactome:REACT_30996
has db xref: Reactome:REACT_77300
has db xref: Reactome:REACT_77934
has db xref: Reactome:REACT_80256
has db xref: Reactome:REACT_84552
has db xref: Reactome:REACT_85890
has db xref: Reactome:REACT_86754
has db xref: Reactome:REACT_88372
has db xref: Reactome:REACT_90393
has db xref: Reactome:REACT_91384
has db xref: Reactome:REACT_94267
has db xref: Reactome:REACT_99750
has exact synonym: L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
has exact synonym: NADPH-diaphorase activity
has exact synonym: NO synthase activity
has exact synonym: nitric oxide synthase activity
has exact synonym: nitric oxide synthetase activity
has exact synonym: nitric-oxide synthetase activity
has OBO namespace: molecular_function
has related synonym: endothelium-derived relaxation factor-forming enzyme activity
has related synonym: endothelium-derived relaxing factor synthase activity
id: GO:0004517
in subset: gosubset prok
type: Class
subclass of: GO_0016709

nuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids.
has db xref: EC:3.1.-.-
has OBO namespace: molecular_function
id: GO:0004518
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim plant
in subset: goslim yeast
in subset: gosubset prok
type: Class
comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subclass of: GO_0016788

endonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
has db xref: Reactome:REACT_100654
has db xref: Reactome:REACT_101397
has db xref: Reactome:REACT_103600
has db xref: Reactome:REACT_106502
has db xref: Reactome:REACT_108614
has db xref: Reactome:REACT_110731
has db xref: Reactome:REACT_112366
has db xref: Reactome:REACT_1124
has db xref: Reactome:REACT_112509
has db xref: Reactome:REACT_112615
has db xref: Reactome:REACT_112782
has db xref: Reactome:REACT_113127
has db xref: Reactome:REACT_113480
has db xref: Reactome:REACT_113819
has db xref: Reactome:REACT_114931
has db xref: Reactome:REACT_115221
has db xref: Reactome:REACT_115226
has db xref: Reactome:REACT_115382
has db xref: Reactome:REACT_115937
has db xref: Reactome:REACT_116011
has db xref: Reactome:REACT_1914
has db xref: Reactome:REACT_34610
has db xref: Reactome:REACT_6746
has db xref: Reactome:REACT_6774
has db xref: Reactome:REACT_77706
has db xref: Reactome:REACT_78624
has db xref: Reactome:REACT_79198
has db xref: Reactome:REACT_80387
has db xref: Reactome:REACT_80628
has db xref: Reactome:REACT_80681
has db xref: Reactome:REACT_80797
has db xref: Reactome:REACT_81714
has db xref: Reactome:REACT_87541
has db xref: Reactome:REACT_89800
has db xref: Reactome:REACT_90034
has db xref: Reactome:REACT_90935
has db xref: Reactome:REACT_92894
has OBO namespace: molecular_function
id: GO:0004519
in subset: gosubset prok
type: Class
subclass of: nuclease activity

endodeoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
has db xref: Reactome:REACT_101184
has db xref: Reactome:REACT_101250
has db xref: Reactome:REACT_101987
has db xref: Reactome:REACT_103441
has db xref: Reactome:REACT_103771
has db xref: Reactome:REACT_104010
has db xref: Reactome:REACT_104673
has db xref: Reactome:REACT_104703
has db xref: Reactome:REACT_104968
has db xref: Reactome:REACT_106756
has db xref: Reactome:REACT_109040
has db xref: Reactome:REACT_109537
has db xref: Reactome:REACT_109692
has db xref: Reactome:REACT_110386
has db xref: Reactome:REACT_112122
has db xref: Reactome:REACT_112152
has db xref: Reactome:REACT_115154
has db xref: Reactome:REACT_115463
has db xref: Reactome:REACT_115479
has db xref: Reactome:REACT_1274
has db xref: Reactome:REACT_1311
has db xref: Reactome:REACT_1964
has db xref: Reactome:REACT_27164
has db xref: Reactome:REACT_27209
has db xref: Reactome:REACT_28610
has db xref: Reactome:REACT_28960
has db xref: Reactome:REACT_30718
has db xref: Reactome:REACT_31162
has db xref: Reactome:REACT_31548
has db xref: Reactome:REACT_31660
has db xref: Reactome:REACT_31823
has db xref: Reactome:REACT_32833
has db xref: Reactome:REACT_33043
has db xref: Reactome:REACT_78421
has db xref: Reactome:REACT_79265
has db xref: Reactome:REACT_80173
has db xref: Reactome:REACT_80298
has db xref: Reactome:REACT_80967
has db xref: Reactome:REACT_811
has db xref: Reactome:REACT_81197
has db xref: Reactome:REACT_82925
has db xref: Reactome:REACT_83838
has db xref: Reactome:REACT_85019
has db xref: Reactome:REACT_88339
has db xref: Reactome:REACT_90087
has db xref: Reactome:REACT_92741
has db xref: Reactome:REACT_94592
has db xref: Reactome:REACT_94820
has db xref: Reactome:REACT_95903
has db xref: Reactome:REACT_97114
has db xref: Reactome:REACT_98405
has db xref: Reactome:REACT_98417
has db xref: Reactome:REACT_99783
has OBO namespace: molecular_function
has related synonym: DNA nicking activity
has related synonym: endonuclease G activity
id: GO:0004520
in subset: gosubset prok
type: Class
subclass of: endonuclease activity
subclass of: deoxyribonuclease activity

endoribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
has db xref: Reactome:REACT_22313
has db xref: Reactome:REACT_75787
has OBO namespace: molecular_function
has related synonym: endonuclease G activity
id: GO:0004521
in subset: gosubset prok
type: Class
subclass of: endonuclease activity
subclass of: ribonuclease activity

pancreatic ribonuclease activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.
has broad synonym: RNase activity
has db xref: EC:3.1.27.5
has db xref: MetaCyc:3.1.27.5-RXN
has db xref: Wikipedia:Ribonuclease_A
has exact synonym: RNase A activity
has exact synonym: RNase I activity
has exact synonym: alkaline ribonuclease activity
has exact synonym: ceratitis capitata alkaline ribonuclease activity
has exact synonym: pancreatic RNase activity
has exact synonym: ribonuclease A
has exact synonym: ribonuclease I activity
has exact synonym: ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity
has exact synonym: ribonucleic phosphatase activity
has OBO namespace: molecular_function
has related synonym: S-genotype-assocd. glycoproteins
has related synonym: SLSG glycoproteins
has related synonym: endoribonuclease I
has related synonym: gene S glycoproteins
has related synonym: gene S locus-specific glycoproteins
id: GO:0004522
type: Class
subclass of: GO_0016892

ribonuclease H activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
has alternative id: GO:0004524
has db xref: EC:3.1.26.4
has db xref: MetaCyc:3.1.26.4-RXN
has db xref: Reactome:REACT_8999
has db xref: Reactome:REACT_9014
has db xref: Reactome:REACT_9040
has db xref: Reactome:REACT_9046
has db xref: Reactome:REACT_9066
has exact synonym: RNA*DNA hybrid ribonucleotidohydrolase activity
has exact synonym: RNase H activity
has exact synonym: calf thymus ribonuclease H activity
has exact synonym: hybrid nuclease activity
has exact synonym: hybrid ribonuclease activity
has exact synonym: hybridase (ribonuclease H)
has exact synonym: hybridase activity
has narrow synonym: RNase H1 activity
has narrow synonym: RNase H2 activity
has narrow synonym: RNase H3 activity
has narrow synonym: endoribonuclease0 H activity
has narrow synonym: ribonuclease H1 activity
has narrow synonym: ribonuclease H2 activity
has narrow synonym: ribonuclease H3 activity
has OBO namespace: molecular_function
has related synonym: endoribonuclease H
has related synonym: endoribonuclease H (calf thymus)
id: GO:0004523
in subset: gosubset prok
type: Class
comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
subclass of: GO_0016891

ribonuclease III activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
has db xref: EC:3.1.26.3
has db xref: MetaCyc:3.1.26.3-RXN
has db xref: Reactome:REACT_101646
has db xref: Reactome:REACT_103474
has db xref: Reactome:REACT_104119
has db xref: Reactome:REACT_106335
has db xref: Reactome:REACT_107961
has db xref: Reactome:REACT_109221
has db xref: Reactome:REACT_109630
has db xref: Reactome:REACT_115273
has db xref: Reactome:REACT_12414
has db xref: Reactome:REACT_12438
has db xref: Reactome:REACT_33849
has db xref: Reactome:REACT_77295
has db xref: Reactome:REACT_77311
has db xref: Reactome:REACT_77692
has db xref: Reactome:REACT_78540
has db xref: Reactome:REACT_79325
has db xref: Reactome:REACT_80484
has db xref: Reactome:REACT_86280
has db xref: Reactome:REACT_90204
has db xref: Reactome:REACT_91920
has db xref: Reactome:REACT_92676
has db xref: Reactome:REACT_95779
has exact synonym: RNase III activity
has exact synonym: ribonuclease 3 activity
has narrow synonym: pre-mRNA 3'-end processing endonuclease
has OBO namespace: molecular_function
id: GO:0004525
in subset: gosubset prok
type: Class
subclass of: GO_0016891

ribonuclease P activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.
has db xref: EC:3.1.26.5
has db xref: MetaCyc:3.1.26.5-RXN
has db xref: Wikipedia:RNase_P
has exact synonym: RNase P
has exact synonym: tRNA 5' leader endonuclease activity
has OBO namespace: molecular_function
id: GO:0004526
in subset: gosubset prok
type: Class
subclass of: tRNA-specific ribonuclease activity
subclass of: GO_0016891

exonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
has alternative id: GO:0008857
has narrow synonym: exonuclease IX activity
has OBO namespace: molecular_function
id: GO:0004527
in subset: gosubset prok
type: Class
subclass of: nuclease activity

phosphodiesterase I activity
IAO_0000115: Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
has broad synonym: phosphodiesterase activity
has db xref: EC:3.1.4.1
has db xref: MetaCyc:3.1.4.1-RXN
has exact synonym: 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
has exact synonym: PDE I activity
has exact synonym: nucleotide pyrophosphatase/phosphodiesterase I activity
has exact synonym: oligonucleate 5'-nucleotidohydrolase activity
has exact synonym: orthophosphoric diester phosphohydrolase activity
has OBO namespace: molecular_function
has related synonym: 5'-NPDase activity
has related synonym: 5'-PDE activity
has related synonym: 5'-PDase activity
has related synonym: 5'-exonuclease activity
has related synonym: 5'-nucleotide phosphodiesterase activity
has related synonym: 5'-phosphodiesterase activity
has related synonym: 5'NPDE activity
has related synonym: alkaline phosphodiesterase activity
has related synonym: exonuclease I activity
id: GO:0004528
in subset: gosubset prok
type: Class
subclass of: exonuclease activity
subclass of: GO_0008081

exodeoxyribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
has OBO namespace: molecular_function
id: GO:0004529
in subset: gosubset prok
type: Class
subclass of: exonuclease activity
subclass of: deoxyribonuclease activity

deoxyribonuclease I activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.
has db xref: EC:3.1.21.1
has db xref: MetaCyc:3.1.21.1-RXN
has exact synonym: DNA depolymerase activity
has exact synonym: DNA endonuclease activity
has exact synonym: DNA nuclease activity
has exact synonym: DNAase activity
has exact synonym: alkaline DNase activity
has exact synonym: alkaline deoxyribonuclease activity
has exact synonym: deoxyribonucleic phosphatase activity
has exact synonym: thymonuclease, dornase activity
has narrow synonym: DNase activity
has narrow synonym: deoxyribonuclease (pancreatic)
has narrow synonym: pancreatic DNase activity
has narrow synonym: pancreatic deoxyribonuclease
has narrow synonym: pancreatic dornase
has narrow synonym: thymonuclease activity
has OBO namespace: molecular_function
has related synonym: DNase I
has related synonym: Escherichia coli endonuclease I
has related synonym: deoxyribonuclease A
has related synonym: dornava
has related synonym: dornavac
has related synonym: endodeoxyribonuclease I
id: GO:0004530
in subset: gosubset prok
type: Class
subclass of: GO_0016888

deoxyribonuclease II activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.
has db xref: EC:3.1.22.1
has db xref: MetaCyc:3.1.22.1-RXN
has exact synonym: DNase II activity
has exact synonym: acid DNase activity
has exact synonym: acid deoxyribonuclease activity
has exact synonym: deoxyribonucleate 3'-nucleotidohydrolase activity
has narrow synonym: lysosomal DNase II activity
has OBO namespace: molecular_function
has related synonym: pancreatic DNase II
id: GO:0004531
in subset: gosubset prok
type: Class
subclass of: GO_0016889

exoribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
has db xref: Reactome:REACT_109605
has db xref: Reactome:REACT_109680
has db xref: Reactome:REACT_20556
has db xref: Reactome:REACT_29104
has db xref: Reactome:REACT_32104
has db xref: Reactome:REACT_78260
has db xref: Reactome:REACT_79364
has db xref: Reactome:REACT_79874
has db xref: Reactome:REACT_87278
has db xref: Reactome:REACT_88925
has db xref: Reactome:REACT_90233
has db xref: Reactome:REACT_94168
has db xref: Reactome:REACT_99687
has db xref: Reactome:REACT_99790
has OBO namespace: molecular_function
id: GO:0004532
in subset: gosubset prok
type: Class
subclass of: exonuclease activity
subclass of: ribonuclease activity

exoribonuclease H activity
IAO_0000115: Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.
has db xref: EC:3.1.13.2
has db xref: MetaCyc:3.1.13.2-RXN
has OBO namespace: molecular_function
has related synonym: retroviral reverse transcriptase RNaseH
id: GO:0004533
type: Class
subclass of: GO_0016896

5'-3' exoribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.
has db xref: EC:3.1.13.-
has db xref: Reactome:REACT_104850
has db xref: Reactome:REACT_112693
has db xref: Reactome:REACT_112806
has db xref: Reactome:REACT_20533
has db xref: Reactome:REACT_20668
has db xref: Reactome:REACT_29760
has db xref: Reactome:REACT_31570
has db xref: Reactome:REACT_81547
has db xref: Reactome:REACT_87069
has db xref: Reactome:REACT_90919
has db xref: Reactome:REACT_94602
has db xref: Reactome:REACT_96418
has db xref: Reactome:REACT_97923
has db xref: Reactome:REACT_99261
has OBO namespace: molecular_function
id: GO:0004534
type: Class
subclass of: GO_0008409
subclass of: GO_0016896

poly(A)-specific ribonuclease activity
IAO_0000115: Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
has db xref: EC:3.1.13.4
has db xref: MetaCyc:3.1.13.4-RXN
has db xref: Reactome:REACT_102015
has db xref: Reactome:REACT_105563
has db xref: Reactome:REACT_106678
has db xref: Reactome:REACT_106922
has db xref: Reactome:REACT_109187
has db xref: Reactome:REACT_111967
has db xref: Reactome:REACT_112457
has db xref: Reactome:REACT_114879
has db xref: Reactome:REACT_20606
has db xref: Reactome:REACT_20651
has db xref: Reactome:REACT_20662
has db xref: Reactome:REACT_28182
has db xref: Reactome:REACT_30223
has db xref: Reactome:REACT_83122
has db xref: Reactome:REACT_85613
has db xref: Reactome:REACT_89076
has db xref: Reactome:REACT_91463
has db xref: Reactome:REACT_92139
has db xref: Reactome:REACT_97042
has exact synonym: 3'-exoribonuclease activity
has exact synonym: poly(A)-specific RNase activity
has OBO namespace: molecular_function
has related synonym: 2',3'-exoribonuclease activity
id: GO:0004535
type: Class
subclass of: 3'-5'-exoribonuclease activity

deoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
has alternative id: GO:0004537
has db xref: Reactome:REACT_100642
has db xref: Reactome:REACT_101208
has db xref: Reactome:REACT_110575
has db xref: Reactome:REACT_13702
has db xref: Reactome:REACT_29722
has db xref: Reactome:REACT_31853
has db xref: Reactome:REACT_90424
has db xref: Reactome:REACT_95359
has db xref: Reactome:REACT_98682
has narrow synonym: caspase-activated deoxyribonuclease activity
has OBO namespace: molecular_function
id: GO:0004536
in subset: gosubset prok
type: Class
subclass of: nuclease activity

ribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
has OBO namespace: molecular_function
id: GO:0004540
in subset: gosubset prok
type: Class
subclass of: nuclease activity

tRNA-specific ribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
has exact synonym: tRNA-specific RNase activity
has OBO namespace: molecular_function
id: GO:0004549
in subset: gosubset prok
type: Class
subclass of: ribonuclease activity

nucleoside diphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
has db xref: EC:2.7.4.6
has db xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN
has db xref: Reactome:REACT_21273
has db xref: Reactome:REACT_21292
has db xref: Reactome:REACT_21362
has db xref: Reactome:REACT_21416
has exact synonym: ATP:nucleoside-diphosphate phosphotransferase activity
has exact synonym: NDK activity
has exact synonym: UDP kinase activity
has exact synonym: nucleoside 5'-diphosphate kinase activity
has exact synonym: nucleoside 5'-diphosphate phosphotransferase activity
has exact synonym: nucleoside diphosphate (UDP) kinase activity
has exact synonym: nucleoside diphosphokinase activity
has exact synonym: nucleoside-diphosphate kinase activity
has exact synonym: nucleotide phosphate kinase activity
has exact synonym: uridine diphosphate kinase activity
has OBO namespace: molecular_function
id: GO:0004550
in subset: gosubset prok
type: Class
subclass of: GO_0016776
subclass of: GO_0019205

nucleotide diphosphatase activity
IAO_0000115: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.
has db xref: EC:3.6.1.9
has db xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN
has db xref: Reactome:REACT_100849
has db xref: Reactome:REACT_101743
has db xref: Reactome:REACT_105775
has db xref: Reactome:REACT_11150
has db xref: Reactome:REACT_114734
has db xref: Reactome:REACT_31241
has db xref: Reactome:REACT_32231
has db xref: Reactome:REACT_32788
has db xref: Reactome:REACT_79725
has db xref: Reactome:REACT_81072
has db xref: Reactome:REACT_85470
has db xref: Reactome:REACT_88676
has db xref: Reactome:REACT_90125
has db xref: Reactome:REACT_90152
has db xref: Reactome:REACT_93217
has exact synonym: dinucleotide nucleotidohydrolase activity
has exact synonym: nucleotide pyrophosphatase activity
has exact synonym: nucleotide-sugar pyrophosphatase activity
has OBO namespace: molecular_function
id: GO:0004551
in subset: gosubset prok
type: Class
subclass of: GO_0016462

octanol dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH.
has db xref: EC:1.1.1.73
has db xref: KEGG:R02878
has db xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN
has db xref: RHEA:24623
has exact synonym: 1-octanol dehydrogenase activity
has exact synonym: octanol:NAD+ oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004552
type: Class
subclass of: GO_0016616

hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the hydrolysis of any O-glycosyl bond.
has alternative id: GO:0016800
has db xref: EC:3.2.1
has exact synonym: O-glucosyl hydrolase activity
has OBO namespace: molecular_function
id: GO:0004553
in subset: gosubset prok
type: Class
subclass of: GO_0016798

alpha,alpha-trehalase activity
IAO_0000115: Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
has db xref: EC:3.2.1.28
has db xref: MetaCyc:TREHALA-RXN
has db xref: RHEA:20871
has db xref: Reactome:REACT_100752
has db xref: Reactome:REACT_107937
has db xref: Reactome:REACT_108455
has db xref: Reactome:REACT_113083
has db xref: Reactome:REACT_28802
has db xref: Reactome:REACT_33073
has db xref: Reactome:REACT_62235
has db xref: Reactome:REACT_83023
has db xref: Reactome:REACT_85697
has db xref: Reactome:REACT_86912
has db xref: Reactome:REACT_88617
has db xref: Reactome:REACT_91694
has db xref: Reactome:REACT_9425
has db xref: Reactome:REACT_9495
has db xref: Reactome:REACT_96425
has exact synonym: alpha,alpha-trehalose glucohydrolase activity
has OBO namespace: molecular_function
id: GO:0004555
in subset: gosubset prok
type: Class
subclass of: GO_0015927

alpha-amylase activity
IAO_0000115: Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
has broad synonym: glycogenase activity
has db xref: EC:3.2.1.1
has db xref: MetaCyc:ALPHA-AMYL-RXN
has db xref: MetaCyc:RXN-1823
has db xref: MetaCyc:RXN-1825
has db xref: Reactome:REACT_103700
has db xref: Reactome:REACT_104713
has db xref: Reactome:REACT_107842
has db xref: Reactome:REACT_108543
has db xref: Reactome:REACT_108602
has db xref: Reactome:REACT_108724
has db xref: Reactome:REACT_108878
has db xref: Reactome:REACT_28419
has db xref: Reactome:REACT_29745
has db xref: Reactome:REACT_31483
has db xref: Reactome:REACT_32139
has db xref: Reactome:REACT_33479
has db xref: Reactome:REACT_79894
has db xref: Reactome:REACT_80072
has db xref: Reactome:REACT_87127
has db xref: Reactome:REACT_88623
has db xref: Reactome:REACT_90361
has db xref: Reactome:REACT_90841
has db xref: Reactome:REACT_90967
has db xref: Reactome:REACT_91720
has db xref: Reactome:REACT_93726
has db xref: Reactome:REACT_9403
has db xref: Reactome:REACT_94289
has db xref: Reactome:REACT_9475
has exact synonym: 1,4-alpha-D-glucan glucanohydrolase activity
has exact synonym: alpha amylase activity
has exact synonym: endoamylase activity
has OBO namespace: molecular_function
has related synonym: taka-amylase A
id: GO:0004556
in subset: gosubset prok
type: Class
subclass of: GO_0016160

alpha-galactosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase.
has db xref: EC:3.2.1.22
has db xref: MetaCyc:ALPHAGALACTOSID-RXN
has db xref: Reactome:REACT_115752
has exact synonym: alpha-D-galactosidase activity
has exact synonym: alpha-D-galactoside galactohydrolase activity
has exact synonym: alpha-galactoside galactohydrolase activity
has exact synonym: melibiase activity
has OBO namespace: molecular_function
has related synonym: alpha-galactosidase A
id: GO:0004557
in subset: gosubset prok
type: Class
subclass of: GO_0015925

alpha-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
has alternative id: GO:0004562
has alternative id: GO:0016982
has broad synonym: lysosomal alpha-glucosidase activity
has db xref: EC:3.2.1.20
has db xref: MetaCyc:MALTODEXGLUCOSID-RXN
has db xref: Reactome:REACT_100920
has db xref: Reactome:REACT_102012
has db xref: Reactome:REACT_103965
has db xref: Reactome:REACT_103976
has db xref: Reactome:REACT_108880
has db xref: Reactome:REACT_112486
has db xref: Reactome:REACT_113312
has db xref: Reactome:REACT_114036
has db xref: Reactome:REACT_32591
has db xref: Reactome:REACT_53202
has db xref: Reactome:REACT_80032
has db xref: Reactome:REACT_82469
has db xref: Reactome:REACT_82683
has db xref: Reactome:REACT_84778
has db xref: Reactome:REACT_84962
has db xref: Reactome:REACT_88169
has db xref: Reactome:REACT_88678
has db xref: Reactome:REACT_88835
has db xref: Reactome:REACT_89837
has db xref: Reactome:REACT_94010
has db xref: Reactome:REACT_9414
has db xref: Reactome:REACT_9424
has db xref: Reactome:REACT_9426
has db xref: Reactome:REACT_9479
has db xref: Reactome:REACT_9506
has db xref: Reactome:REACT_95331
has db xref: Reactome:REACT_97286
has db xref: Reactome:REACT_97290
has db xref: Reactome:REACT_97456
has exact synonym: acid maltase activity
has exact synonym: alpha-1,4-glucosidase activity
has exact synonym: alpha-D-glucosidase activity
has exact synonym: alpha-D-glucoside glucohydrolase activity
has exact synonym: alpha-glucopyranosidase activity
has exact synonym: alpha-glucoside hydrolase activity
has exact synonym: glucoinvertase activity
has exact synonym: glucosidoinvertase activity
has exact synonym: glucosidosucrase activity
has exact synonym: maltase-glucoamylase activity
has OBO namespace: molecular_function
has related synonym: alpha-glucosidase II
id: GO:0004558
in subset: gosubset prok
type: Class
subclass of: GO_0015926

alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
has db xref: EC:3.2.1.24
has db xref: MetaCyc:3.2.1.24-RXN
has db xref: Reactome:REACT_24995
has db xref: Reactome:REACT_25093
has db xref: Reactome:REACT_25126
has db xref: Reactome:REACT_25313
has exact synonym: alpha-D-mannopyranosidase activity
has exact synonym: alpha-D-mannosidase activity
has exact synonym: alpha-D-mannoside mannohydrolase activity
has exact synonym: exo-alpha-mannosidase activity
has narrow synonym: 1,2-alpha-D-mannosidase activity
has narrow synonym: 1,2-alpha-mannosidase
has narrow synonym: p-nitrophenyl-alpha-mannosidase activity
has OBO namespace: molecular_function
id: GO:0004559
in subset: gosubset prok
type: Class
subclass of: GO_0015923

alpha-L-fucosidase activity
IAO_0000115: Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.
has db xref: EC:3.2.1.51
has db xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN
has exact synonym: alpha-L-fucoside fucohydrolase activity
has exact synonym: alpha-fucosidase activity
has OBO namespace: molecular_function
id: GO:0004560
in subset: gosubset prok
type: Class
subclass of: GO_0015928

alpha-N-acetylglucosaminidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.
has db xref: EC:3.2.1.50
has db xref: MetaCyc:3.2.1.50-RXN
has exact synonym: N-acetyl-alpha-D-glucosaminidase activity
has exact synonym: N-acetyl-alpha-glucosaminidase activity
has exact synonym: NAG activity
has exact synonym: alpha-D-2-acetamido-2-deoxyglucosidase activity
has exact synonym: alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity
has exact synonym: alpha-acetylglucosaminidase activity
has OBO namespace: molecular_function
id: GO:0004561
type: Class
subclass of: GO_0015929

beta-N-acetylhexosaminidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
has db xref: EC:3.2.1.52
has db xref: MetaCyc:3.2.1.52-RXN
has db xref: Reactome:REACT_115753
has db xref: Reactome:REACT_115984
has exact synonym: N-acetyl-beta-D-hexosaminidase activity
has exact synonym: N-acetyl-beta-glucosaminidase activity
has exact synonym: N-acetyl-beta-hexosaminidase activity
has exact synonym: N-acetylhexosaminidase activity
has exact synonym: beta-D-N-acetylhexosaminidase activity
has exact synonym: beta-D-hexosaminidase activity
has exact synonym: beta-N-acetyl-D-hexosaminidase activity
has exact synonym: beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity
has exact synonym: beta-acetylaminodeoxyhexosidase activity
has exact synonym: beta-acetylhexosaminidinase activity
has exact synonym: beta-hexosaminidase activity
has OBO namespace: molecular_function
has related synonym: hexosaminidase A
id: GO:0004563
in subset: gosubset prok
type: Class
subclass of: GO_0015929

beta-fructofuranosidase activity
IAO_0000115: Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside.
has broad synonym: acid invertase activity
has broad synonym: alkaline invertase activity
has broad synonym: invertase activity
has broad synonym: invertin activity
has db xref: EC:3.2.1.26
has db xref: MetaCyc:RXN-9985
has exact synonym: beta-D-fructofuranoside fructohydrolase activity
has OBO namespace: molecular_function
has related synonym: beta-fructosidase activity
has related synonym: beta-h-fructosidase activity
has related synonym: fructosylinvertase activity
has related synonym: glucosucrase activity
has related synonym: maxinvert L 1000 activity
has related synonym: saccharase activity
id: GO:0004564
in subset: gosubset prok
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

beta-galactosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
has db xref: EC:3.2.1.23
has db xref: MetaCyc:3.2.1.23-RXN
has db xref: MetaCyc:BGALACT-PWY
has db xref: Reactome:REACT_115597
has db xref: Reactome:REACT_115930
has exact synonym: beta-D-galactanase activity
has exact synonym: beta-D-galactoside galactohydrolase activity
has exact synonym: beta-D-lactosidase activity
has exact synonym: beta-lactosidase activity
has exact synonym: exo-(1->4)-beta-D-galactanase activity
has exact synonym: trilactase activity
has OBO namespace: molecular_function
has related synonym: S 2107
has related synonym: hydrolact
has related synonym: lactose hydrolysis
has related synonym: lactozym
has related synonym: maxilact
has related synonym: oryzatym
has related synonym: sumiklat
id: GO:0004565
in subset: gosubset prok
type: Class
comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase.
subclass of: GO_0015925

beta-glucuronidase activity
IAO_0000115: Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.
has db xref: EC:3.2.1.31
has db xref: MetaCyc:BETA-GLUCURONID-RXN
has exact synonym: beta-D-glucuronoside glucuronosohydrolase activity
has exact synonym: beta-glucuronide glucuronohydrolase activity
has exact synonym: exo-beta-D-glucuronidase activity
has exact synonym: glucuronidase activity
has exact synonym: ketodase activity
has OBO namespace: molecular_function
id: GO:0004566
in subset: gosubset prok
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

beta-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.
has db xref: EC:3.2.1.25
has db xref: MetaCyc:3.2.1.25-RXN
has exact synonym: beta-D-mannosidase activity
has exact synonym: beta-D-mannoside mannohydrolase activity
has exact synonym: beta-mannoside mannohydrolase activity
has exact synonym: exo-beta-D-mannanase activity
has exact synonym: mannanase activity
has exact synonym: mannase activity
has OBO namespace: molecular_function
id: GO:0004567
in subset: gosubset prok
type: Class
subclass of: GO_0015923

chitinase activity
IAO_0000115: Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.
has db xref: EC:3.2.1.14
has db xref: MetaCyc:3.2.1.14-RXN
has exact synonym: 1,4-beta-poly-N-acetylglucosaminidase activity
has exact synonym: beta-1,4-poly-N-acetyl glucosamidinase activity
has exact synonym: chitodextrinase activity
has exact synonym: poly-beta-glucosaminidase activity
has exact synonym: poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity
has OBO namespace: molecular_function
id: GO:0004568
in subset: gosubset prok
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

glycoprotein endo-alpha-1,2-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.
has db xref: EC:3.2.1.130
has db xref: MetaCyc:3.2.1.130-RXN
has db xref: Reactome:REACT_25136
has exact synonym: endo-alpha-mannosidase activity
has exact synonym: endomannosidase activity
has exact synonym: glucosyl mannosidase activity
has exact synonym: glucosylmannosidase activity
has exact synonym: glycoprotein glucosylmannohydrolase activity
has OBO namespace: molecular_function
id: GO:0004569
type: Class
subclass of: alpha-mannosidase activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
has broad synonym: 1,2-alpha-mannosidase
has db xref: EC:3.2.1.113
has db xref: MetaCyc:3.2.1.113-RXN
has db xref: Reactome:REACT_25205
has db xref: Reactome:REACT_25217
has db xref: Reactome:REACT_25341
has exact synonym: 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
has exact synonym: Man9-mannosidase activity
has exact synonym: exo-alpha-1,2-mannanase activity
has exact synonym: mannose-9 processing alpha-mannosidase activity
has narrow synonym: ManI activity
has narrow synonym: mannosidase 1A activity
has narrow synonym: mannosidase 1B activity
has OBO namespace: molecular_function
has related synonym: glycoprotein processing mannosidase I
has related synonym: man9-mannosidase activity
has related synonym: mannosidase I
id: GO:0004571
in subset: gosubset prok
type: Class
subclass of: GO_0015924

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
has db xref: EC:3.2.1.114
has db xref: MetaCyc:3.2.1.114-RXN
has db xref: Reactome:REACT_25047
has exact synonym: 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity
has exact synonym: GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity
has exact synonym: alpha-(1,3/6)-mannosidase activity
has exact synonym: exo-1,3-1,6-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity
has narrow synonym: ManII activity
has narrow synonym: mannosidase II activity
has OBO namespace: molecular_function
has related synonym: Golgi alpha-mannosidase II
has related synonym: alpha-D-mannosidase II
has related synonym: alpha-mannosidase II
id: GO:0004572
type: Class
subclass of: GO_0015924

mannosyl-oligosaccharide glucosidase activity
IAO_0000115: Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
has db xref: EC:3.2.1.106
has db xref: MetaCyc:3.2.1.106-RXN
has db xref: Reactome:REACT_23855
has exact synonym: Glc3Man9NAc2 oligosaccharide glucosidase activity
has exact synonym: mannosyl-oligosaccharide glucohydrolase activity
has exact synonym: mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity
has OBO namespace: molecular_function
has related synonym: processing A-glucosidase I activity
has related synonym: trimming glucosidase I
id: GO:0004573
type: Class
subclass of: GO_0015926

oligo-1,6-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.
has broad synonym: limit dextrinase (erroneous)
has db xref: EC:3.2.1.10
has db xref: MetaCyc:3.2.1.10-RXN
has exact synonym: alpha-limit dextrinase activity
has exact synonym: dextrin 6-glucanohydrolase activity
has exact synonym: dextrin 6alpha-glucanohydrolase activity
has exact synonym: exo-oligo-1,6-glucosidase activity
has exact synonym: oligosaccharide alpha-1,6-glucohydrolase activity
has exact synonym: oligosaccharide alpha-1,6-glucosidase activity
has OBO namespace: molecular_function
has related synonym: isomaltase activity
has related synonym: sucrase-isomaltase activity
id: GO:0004574
in subset: gosubset prok
type: Class
subclass of: GO_0015926

sucrose alpha-glucosidase activity
IAO_0000115: Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.
has broad synonym: alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis
has broad synonym: beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis
has broad synonym: sucrose hydrolysis
has db xref: EC:3.2.1.26
has db xref: EC:3.2.1.48
has db xref: KEGG:R00802
has db xref: MetaCyc:RXN-1461
has db xref: Reactome:REACT_109028
has db xref: Reactome:REACT_110486
has db xref: Reactome:REACT_113531
has db xref: Reactome:REACT_29388
has db xref: Reactome:REACT_31778
has db xref: Reactome:REACT_46717
has db xref: Reactome:REACT_77700
has db xref: Reactome:REACT_9409
has db xref: Reactome:REACT_97464
has exact synonym: sucrose alpha-D-glucohydrolase activity
has exact synonym: sucrose alpha-glucohydrolase activity
has exact synonym: sucrose-alpha-D-glucohydrolase activity
has OBO namespace: molecular_function
has related synonym: intestinal sucrase activity
has related synonym: sucrase activity
has related synonym: sucrase(invertase)
has related synonym: sucrase-isomaltase activity
id: GO:0004575
type: Class
subclass of: alpha-glucosidase activity
subclass of: beta-fructofuranosidase activity

oligosaccharyl transferase activity
IAO_0000115: Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.
has db xref: EC:2.4.1.-
has exact synonym: oligosaccharide transferase activity
has OBO namespace: molecular_function
id: GO:0004576
in subset: gosubset prok
type: Class
subclass of: GO_0016758

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol.
has db xref: EC:2.4.1.141
has db xref: MetaCyc:2.4.1.141-RXN
has db xref: Reactome:REACT_22332
has exact synonym: N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity
has exact synonym: UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity
has OBO namespace: molecular_function
id: GO:0004577
type: Class
subclass of: GO_0008375

chitobiosyldiphosphodolichol beta-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.
has db xref: EC:2.4.1.142
has db xref: MetaCyc:2.4.1.142-RXN
has db xref: Reactome:REACT_22214
has exact synonym: GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity
has exact synonym: GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity
has exact synonym: guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004578
type: Class
subclass of: GO_0019187

dolichyl-diphosphooligosaccharide-protein glycotransferase activity
IAO_0000115: Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.
has db xref: EC:2.4.1.119
has db xref: MetaCyc:2.4.1.119-RXN
has db xref: Reactome:REACT_100173
has db xref: Reactome:REACT_104542
has db xref: Reactome:REACT_105113
has db xref: Reactome:REACT_107399
has db xref: Reactome:REACT_108138
has db xref: Reactome:REACT_109815
has db xref: Reactome:REACT_110217
has db xref: Reactome:REACT_22208
has db xref: Reactome:REACT_28545
has db xref: Reactome:REACT_32860
has db xref: Reactome:REACT_32942
has db xref: Reactome:REACT_84238
has db xref: Reactome:REACT_85218
has db xref: Reactome:REACT_87422
has db xref: Reactome:REACT_88737
has db xref: Reactome:REACT_94087
has db xref: Reactome:REACT_95564
has exact synonym: asparagine N-glycosyltransferase activity
has exact synonym: dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity
has exact synonym: dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity
has exact synonym: dolichyldiphosphooligosaccharide-protein glycosyltransferase activity
has exact synonym: dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity
has exact synonym: dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity
has exact synonym: dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity
has OBO namespace: molecular_function
has related synonym: oligomannosyltransferase activity
id: GO:0004579
type: Class
subclass of: oligosaccharyl transferase activity

dolichyl-phosphate beta-glucosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.
has db xref: EC:2.4.1.117
has db xref: MetaCyc:2.4.1.117-RXN
has db xref: RHEA:15404
has db xref: Reactome:REACT_100680
has db xref: Reactome:REACT_104794
has db xref: Reactome:REACT_104813
has db xref: Reactome:REACT_107904
has db xref: Reactome:REACT_22143
has db xref: Reactome:REACT_33304
has db xref: Reactome:REACT_80993
has db xref: Reactome:REACT_88104
has db xref: Reactome:REACT_88352
has db xref: Reactome:REACT_89501
has db xref: Reactome:REACT_90951
has db xref: Reactome:REACT_90956
has db xref: Reactome:REACT_92824
has db xref: Reactome:REACT_94061
has db xref: Reactome:REACT_95026
has db xref: Reactome:REACT_95736
has db xref: Reactome:REACT_96949
has exact synonym: UDP-glucose dolichyl-phosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolichol phosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolicholphosphoryl glucosyltransferase activity
has exact synonym: UDP-glucose:dolichyl monophosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolichyl phosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity
has exact synonym: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity
has exact synonym: polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity
has exact synonym: uridine diphosphoglucose-dolichol glucosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004581
in subset: gosubset prok
type: Class
subclass of: GO_0035251

dolichyl-phosphate beta-D-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
has db xref: EC:2.4.1.83
has db xref: MetaCyc:2.4.1.83-RXN
has db xref: RHEA:21187
has db xref: Reactome:REACT_108294
has db xref: Reactome:REACT_2036
has db xref: Reactome:REACT_78249
has db xref: Reactome:REACT_85479
has db xref: Reactome:REACT_92201
has db xref: Reactome:REACT_95377
has db xref: Reactome:REACT_95543
has db xref: Reactome:REACT_97879
has exact synonym: DPM synthase activity
has exact synonym: GDP-mannose-dolichol phosphate mannosyltransferase activity
has exact synonym: GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity
has exact synonym: GDPMan:DolP mannosyltransferase activity
has exact synonym: GDPmannose-dolichylmonophosphate mannosyltransferase activity
has exact synonym: GDPmannose:dolichyl-phosphate mannosyltransferase activity
has exact synonym: dolichol phosphate mannose synthase activity
has exact synonym: dolichol-phosphate mannose synthase activity
has exact synonym: dolichol-phosphate mannosyltransferase activity
has exact synonym: dolichol-phosphate-mannose synthase activity
has exact synonym: dolichyl mannosyl phosphate synthase activity
has exact synonym: dolichyl phosphate mannosyltransferase activity
has exact synonym: dolichyl-phosphate mannose synthase activity
has exact synonym: dolichyl-phospho-mannose synthase activity
has exact synonym: guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity
has exact synonym: mannosylphosphodolichol synthase activity
has exact synonym: mannosylphosphoryldolichol synthase activity
has OBO namespace: molecular_function
id: GO:0004582
in subset: gosubset prok
type: Class
subclass of: mannosyltransferase activity

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
IAO_0000115: Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.
has db xref: EC:2.4.1.-
has db xref: MetaCyc:RXN-5472
has db xref: Reactome:REACT_116026
has db xref: Reactome:REACT_22158
has db xref: Reactome:REACT_22194
has db xref: Reactome:REACT_22406
has OBO namespace: molecular_function
id: GO:0004583
type: Class
subclass of: GO_0046527

dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide.
has broad synonym: oligomannosylsynthase activity
has db xref: EC:2.4.1.130
has db xref: MetaCyc:2.4.1.130-RXN
has exact synonym: dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity
has exact synonym: dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity
has OBO namespace: molecular_function
id: GO:0004584
in subset: mf needs review
type: Class
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subclass of: mannosyltransferase activity

ornithine carbamoyltransferase activity
IAO_0000115: Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
has db xref: EC:2.1.3.3
has db xref: MetaCyc:ORNCARBAMTRANSFER-RXN
has db xref: RHEA:19516
has db xref: Reactome:REACT_102870
has db xref: Reactome:REACT_105226
has db xref: Reactome:REACT_106259
has db xref: Reactome:REACT_108269
has db xref: Reactome:REACT_108782
has db xref: Reactome:REACT_115561
has db xref: Reactome:REACT_29449
has db xref: Reactome:REACT_30313
has db xref: Reactome:REACT_30784
has db xref: Reactome:REACT_32381
has db xref: Reactome:REACT_32826
has db xref: Reactome:REACT_75706
has db xref: Reactome:REACT_77338
has db xref: Reactome:REACT_78698
has db xref: Reactome:REACT_801
has db xref: Reactome:REACT_83411
has db xref: Reactome:REACT_91782
has db xref: Reactome:REACT_95450
has db xref: Reactome:REACT_96735
has exact synonym: L-ornithine carbamoyltransferase activity
has exact synonym: L-ornithine carbamyltransferase activity
has exact synonym: L-ornithine transcarbamylase activity
has exact synonym: OTC activity
has exact synonym: OTCase activity
has exact synonym: carbamoyl-phosphate:L-ornithine carbamoyltransferase activity
has exact synonym: carbamylphosphate-ornithine transcarbamylase activity
has exact synonym: citrulline phosphorylase activity
has exact synonym: ornithine carbamyltransferase activity
has exact synonym: ornithine transcarbamylase activity
has OBO namespace: molecular_function
id: GO:0004585
in subset: gosubset prok
type: Class
subclass of: GO_0016743

ornithine decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine.
has db xref: EC:4.1.1.17
has db xref: KEGG:R00670
has db xref: MetaCyc:ORNDECARBOX-RXN
has db xref: RHEA:22967
has db xref: Reactome:REACT_100009
has db xref: Reactome:REACT_101053
has db xref: Reactome:REACT_104668
has db xref: Reactome:REACT_105219
has db xref: Reactome:REACT_112162
has db xref: Reactome:REACT_112888
has db xref: Reactome:REACT_1211
has db xref: Reactome:REACT_77092
has db xref: Reactome:REACT_80374
has db xref: Reactome:REACT_84059
has db xref: Reactome:REACT_85384
has db xref: Reactome:REACT_86039
has db xref: Reactome:REACT_91626
has db xref: Reactome:REACT_98211
has exact synonym: L-ornithine carboxy-lyase (putrescine-forming)
has narrow synonym: L-ornithine carboxy-lyase activity
has OBO namespace: molecular_function
has related synonym: SpeC
id: GO:0004586
in subset: gosubset prok
type: Class
subclass of: GO_0016831

ornithine-oxo-acid transaminase activity
IAO_0000115: Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
has db xref: EC:2.6.1.13
has db xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
has db xref: Reactome:REACT_103734
has db xref: Reactome:REACT_103755
has db xref: Reactome:REACT_104089
has db xref: Reactome:REACT_104115
has db xref: Reactome:REACT_105173
has db xref: Reactome:REACT_105305
has db xref: Reactome:REACT_105934
has db xref: Reactome:REACT_107551
has db xref: Reactome:REACT_108038
has db xref: Reactome:REACT_108473
has db xref: Reactome:REACT_108492
has db xref: Reactome:REACT_109492
has db xref: Reactome:REACT_110278
has db xref: Reactome:REACT_110724
has db xref: Reactome:REACT_110765
has db xref: Reactome:REACT_112121
has db xref: Reactome:REACT_113272
has db xref: Reactome:REACT_14
has db xref: Reactome:REACT_189
has db xref: Reactome:REACT_31040
has db xref: Reactome:REACT_32966
has db xref: Reactome:REACT_33214
has db xref: Reactome:REACT_33525
has db xref: Reactome:REACT_40426
has db xref: Reactome:REACT_77726
has db xref: Reactome:REACT_79140
has db xref: Reactome:REACT_81862
has db xref: Reactome:REACT_82235
has db xref: Reactome:REACT_82330
has db xref: Reactome:REACT_83055
has db xref: Reactome:REACT_84256
has db xref: Reactome:REACT_84499
has db xref: Reactome:REACT_84818
has db xref: Reactome:REACT_86964
has db xref: Reactome:REACT_87737
has db xref: Reactome:REACT_91344
has db xref: Reactome:REACT_93443
has db xref: Reactome:REACT_96745
has db xref: Reactome:REACT_96800
has db xref: Reactome:REACT_96922
has db xref: Reactome:REACT_99431
has db xref: Reactome:REACT_99615
has exact synonym: L-ornithine 5-aminotransferase activity
has exact synonym: L-ornithine aminotransferase activity
has exact synonym: L-ornithine:2-oxo-acid aminotransferase activity
has exact synonym: L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
has exact synonym: ornithine 5-aminotransferase activity
has exact synonym: ornithine aminotransferase activity
has exact synonym: ornithine delta-transaminase activity
has exact synonym: ornithine ketoacid aminotransferase activity
has exact synonym: ornithine transaminase activity
has exact synonym: ornithine--2-oxoacid aminotransferase activity
has exact synonym: ornithine--alpha-ketoglutarate aminotransferase activity
has exact synonym: ornithine--keto acid aminotransferase activity
has exact synonym: ornithine--keto acid transaminase activity
has exact synonym: ornithine--ketoglutarate aminotransferase activity
has exact synonym: ornithine--oxo acid aminotransferase activity
has exact synonym: ornithine--oxo-acid transaminase activity
has exact synonym: ornithine-oxo-acid aminotransferase activity
has exact synonym: ornithine:alpha-oxoglutarate transaminase activity
has OBO namespace: molecular_function
has related synonym: GabT
has related synonym: OAT
id: GO:0004587
in subset: gosubset prok
type: Class
subclass of: GO_0008483

orotate phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
has db xref: EC:2.4.2.10
has db xref: MetaCyc:OROPRIBTRANS-RXN
has db xref: RHEA:10383
has db xref: Reactome:REACT_103862
has db xref: Reactome:REACT_105415
has db xref: Reactome:REACT_107524
has db xref: Reactome:REACT_109836
has db xref: Reactome:REACT_116017
has db xref: Reactome:REACT_29302
has db xref: Reactome:REACT_31825
has db xref: Reactome:REACT_32164
has db xref: Reactome:REACT_33
has db xref: Reactome:REACT_80131
has db xref: Reactome:REACT_80763
has db xref: Reactome:REACT_81434
has db xref: Reactome:REACT_81573
has db xref: Reactome:REACT_83708
has db xref: Reactome:REACT_85647
has db xref: Reactome:REACT_87670
has db xref: Reactome:REACT_88329
has db xref: Reactome:REACT_89343
has db xref: Reactome:REACT_90104
has db xref: Reactome:REACT_91486
has db xref: Reactome:REACT_98456
has db xref: Reactome:REACT_99043
has exact synonym: OPRT activity
has exact synonym: OPRTase activity
has exact synonym: orotate phosphoribosyl pyrophosphate transferase activity
has exact synonym: orotic acid phosphoribosyltransferase activity
has exact synonym: orotidine 5'-monophosphate pyrophosphorylase activity
has exact synonym: orotidine monophosphate pyrophosphorylase activity
has exact synonym: orotidine phosphoribosyltransferase activity
has exact synonym: orotidine-5'-phosphate diphosphorylase activity
has exact synonym: orotidine-5'-phosphate pyrophosphorylase activity
has exact synonym: orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity
has exact synonym: orotidylate phosphoribosyltransferase activity
has exact synonym: orotidylate pyrophosphorylase activity
has exact synonym: orotidylic acid phosphorylase activity
has exact synonym: orotidylic acid pyrophosphorylase activity
has exact synonym: orotidylic phosphorylase activity
has exact synonym: orotidylic pyrophosphorylase activity
has OBO namespace: molecular_function
id: GO:0004588
in subset: gosubset prok
type: Class
subclass of: GO_0016763

orotate reductase (NADH) activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate.
has db xref: EC:1.3.1.14
has db xref: KEGG:R01869
has db xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN
has db xref: RHEA:13516
has exact synonym: (S)-dihydroorotate:NAD+ oxidoreductase activity
has OBO namespace: molecular_function
id: GO:0004589
type: Class
subclass of: GO_0016628

orotidine-5'-phosphate decarboxylase activity
IAO_0000115: Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.
has db xref: EC:4.1.1.23
has db xref: KEGG:R00965
has db xref: MetaCyc:OROTPDECARB-RXN
has db xref: RHEA:11599
has db xref: Reactome:REACT_100167
has db xref: Reactome:REACT_100807
has db xref: Reactome:REACT_102878
has db xref: Reactome:REACT_105495
has db xref: Reactome:REACT_106941
has db xref: Reactome:REACT_108553
has db xref: Reactome:REACT_110007
has db xref: Reactome:REACT_110276
has db xref: Reactome:REACT_115671
has db xref: Reactome:REACT_225
has db xref: Reactome:REACT_28167
has db xref: Reactome:REACT_31689
has db xref: Reactome:REACT_34349
has db xref: Reactome:REACT_80816
has db xref: Reactome:REACT_82540
has db xref: Reactome:REACT_83379
has db xref: Reactome:REACT_83718
has db xref: Reactome:REACT_85504
has db xref: Reactome:REACT_86018
has db xref: Reactome:REACT_86723
has db xref: Reactome:REACT_91989
has db xref: Reactome:REACT_93464
has exact synonym: ODCase activity
has exact synonym: OMP decarboxylase activity
has exact synonym: OMPdcase activity
has exact synonym: UMP synthase activity
has exact synonym: orotate decarboxylase activity
has exact synonym: orotate monophosphate decarboxylase activity
has exact synonym: orotic decarboxylase activity
has exact synonym: orotidine 5'-phosphate decarboxylase activity
has exact synonym: orotidine monophosphate decarboxylase activity
has exact synonym: orotidine phosphate decarboxylase activity
has exact synonym: orotidine-5'-monophosphate decarboxylase activity
has exact synonym: orotidine-5'-phosphate carboxy-lyase (UMP-forming)
has exact synonym: orotidine-5'-phosphate carboxy-lyase activity
has exact synonym: orotidylic acid decarboxylase activity
has exact synonym: orotidylic decarboxylase activity
has exact synonym: orotodylate decarboxylase activity
has exact synonym: uridine 5'-monophosphate synthase activity
has OBO namespace: molecular_function
has related synonym: OMP-DC
id: GO:0004590
in subset: gosubset prok
type: Class
subclass of: GO_0016831

oxoglutarate dehydrogenase (succinyl-transferring) activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.
has db xref: EC:1.2.4.2
has db xref: MetaCyc:2OXOGLUTDECARB-RXN
has exact synonym: 2-ketoglutarate dehydrogenase activity
has exact synonym: 2-oxoglutarate dehydrogenase activity
has exact synonym: 2-oxoglutarate: lipoate oxidoreductase activity
has exact synonym: 2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
has exact synonym: 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity
has exact synonym: AKGDH activity
has exact synonym: OGDC activity
has exact synonym: alpha-ketoglutarate dehydrogenase activity
has exact synonym: alpha-ketoglutaric acid dehydrogenase activity
has exact synonym: alpha-ketoglutaric dehydrogenase activity
has exact synonym: alpha-oxoglutarate dehydrogenase activity
has exact synonym: ketoglutaric dehydrogenase activity
has exact synonym: oxoglutarate decarboxylase activity
has exact synonym: oxoglutarate dehydrogenase (lipoamide) activity
has exact synonym: oxoglutarate dehydrogenase activity
has OBO namespace: molecular_function
id: GO:0004591
in subset: gosubset prok
type: Class
subclass of: GO_0016624

pantoate-beta-alanine ligase activity
IAO_0000115: Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
has db xref: EC:6.3.2.1
has db xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN
has db xref: RHEA:10915
has exact synonym: (R)-pantoate:beta-alanine ligase (AMP-forming)
has exact synonym: D-pantoate:beta-alanine ligase (AMP-forming)
has exact synonym: pantothenate synthetase activity
has OBO namespace: molecular_function
has related synonym: pantoate-activating enzyme activity
has related synonym: pantoic-activating enzyme activity
id: GO:0004592
in subset: gosubset prok
type: Class
subclass of: GO_0016881

pantothenase activity
IAO_0000115: Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine.
has db xref: EC:3.5.1.22
has db xref: KEGG:R02474
has db xref: MetaCyc:PANTOTHENASE-RXN
has db xref: RHEA:12451
has exact synonym: (R)-pantothenate amidohydrolase activity
has exact synonym: pantothenate amidohydrolase activity
has exact synonym: pantothenate hydrolase activity
has OBO namespace: molecular_function
id: GO:0004593
type: Class
subclass of: GO_0016811

pantothenate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
has db xref: EC:2.7.1.33
has db xref: MetaCyc:PANTOTHENATE-KIN-RXN
has db xref: RHEA:16376
has db xref: Reactome:REACT_100199
has db xref: Reactome:REACT_102890
has db xref: Reactome:REACT_103860
has db xref: Reactome:REACT_106034
has db xref: Reactome:REACT_106911
has db xref: Reactome:REACT_109193
has db xref: Reactome:REACT_11129
has db xref: Reactome:REACT_11197
has db xref: Reactome:REACT_112157
has db xref: Reactome:REACT_112376
has db xref: Reactome:REACT_113306
has db xref: Reactome:REACT_33195
has db xref: Reactome:REACT_34346
has db xref: Reactome:REACT_34667
has db xref: Reactome:REACT_77458
has db xref: Reactome:REACT_78875
has db xref: Reactome:REACT_80667
has db xref: Reactome:REACT_81648
has db xref: Reactome:REACT_84596
has db xref: Reactome:REACT_85838
has db xref: Reactome:REACT_86443
has db xref: Reactome:REACT_86843
has db xref: Reactome:REACT_90072
has db xref: Reactome:REACT_93775
has db xref: Reactome:REACT_94823
has db xref: Reactome:REACT_96043
has exact synonym: ATP:(R)-pantothenate 4'-phosphotransferase activity
has exact synonym: ATP:pantothenate 4'-phosphotransferase activity
has exact synonym: D-pantothenate kinase activity
has exact synonym: pantothenate kinase (phosphorylating) activity
has exact synonym: pantothenic acid kinase activity
has OBO namespace: molecular_function
id: GO:0004594
in subset: gosubset prok
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

pantetheine-phosphate adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.
has db xref: EC:2.7.7.3
has db xref: KEGG:R03035
has db xref: MetaCyc:PANTEPADENYLYLTRAN-RXN
has db xref: RHEA:19804
has db xref: Reactome:REACT_101882
has db xref: Reactome:REACT_107996
has db xref: Reactome:REACT_110459
has db xref: Reactome:REACT_11222
has db xref: Reactome:REACT_113938
has db xref: Reactome:REACT_30920
has db xref: Reactome:REACT_31370
has db xref: Reactome:REACT_34054
has db xref: Reactome:REACT_78737
has db xref: Reactome:REACT_81268
has db xref: Reactome:REACT_84118
has db xref: Reactome:REACT_88574
has db xref: Reactome:REACT_92290
has exact synonym: 3'-dephospho-CoA pyrophosphorylase activity
has exact synonym: ATP:pantetheine-4'-phosphate adenylyltransferase activity
has exact synonym: ATP:pantetheine-phosphate adenylyltransferase activity
has exact synonym: PPAT activity
has exact synonym: dephospho-CoA diphosphorylase activity
has exact synonym: dephospho-CoA pyrophosphorylase activity
has exact synonym: dephospho-coenzyme A pyrophosphorylase activity
has exact synonym: pantetheine phosphate adenylyltransferase activity
has exact synonym: phosphopantetheine adenylyltransferase activity
has OBO namespace: molecular_function
id: GO:0004595
in subset: gosubset prok
type: Class
subclass of: GO_0070566

peptide alpha-N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
has db xref: EC:2.3.1.88
has db xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN
has exact synonym: acetyl-CoA:peptide alpha-N-acetyltransferase activity
has exact synonym: acetyl-CoA:peptide nalpha-acetyltransferase activity
has exact synonym: nalpha-acetyltransferase activity
has exact synonym: protein N-terminal acetyltransferase activity
has narrow synonym: beta-endorphin acetyltransferase activity
has OBO namespace: molecular_function
has related synonym: N(alpha)-acetyltransferase activity
has related synonym: NAT activity
has related synonym: amino-terminal amino acid-acetylating enzyme activity
has related synonym: peptide acetyltransferase activity
id: GO:0004596
in subset: gosubset prok
type: Class
subclass of: GO_0034212

peptide-aspartate beta-dioxygenase activity
IAO_0000115: Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2.
has db xref: EC:1.14.11.16
has db xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN
has exact synonym: aspartate beta-hydroxylase activity
has exact synonym: aspartylpeptide beta-dioxygenase activity
has exact synonym: peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
has OBO namespace: molecular_function
has related synonym: aspartyl/asparaginyl beta-hydroxylase activity
id: GO:0004597
in subset: gosubset prok
type: Class
subclass of: GO_0016706