mitochondrion inheritance
IAO_0000115: The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.
has exact synonym: mitochondrial inheritance
type: Class
subclass of: GO_0048308
subclass of: GO_0048311

mitochondrial genome maintenance
IAO_0000115: The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
type: Class
subclass of: GO_0007005

reproduction
IAO_0000115: The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
has exact synonym: reproductive physiological process
replaces: GO_0019952
replaces: GO_0050876
type: Class
subclass of: GO_0008150

obsolete ribosomal chaperone activity
IAO_0000115: OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function.
type: Class
subclass of: ObsoleteClass

high-affinity zinc transmembrane transporter activity
IAO_0000115: Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
has exact synonym: high affinity zinc uptake transmembrane transporter activity
has related synonym: high-affinity zinc uptake transmembrane transporter activity
type: Class
subclass of: GO_0005385

low-affinity zinc ion transmembrane transporter activity
IAO_0000115: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
type: Class
subclass of: GO_0005385

obsolete thioredoxin
IAO_0000115: OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol.
replaces: GO_0000013
type: Class
subclass of: ObsoleteClass

alpha-1,6-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.
has exact synonym: 1,6-alpha-mannosyltransferase activity
type: Class
subclass of: mannosyltransferase activity

trans-hexaprenyltranstransferase activity
IAO_0000115: Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate.
type: Class
subclass of: GO_0016765

vacuole inheritance
IAO_0000115: The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.
type: Class
subclass of: GO_0007033
subclass of: GO_0048308

single strand break repair
IAO_0000115: The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.
type: Class
subclass of: GO_0006281

single-stranded DNA endodeoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.
has related synonym: single-stranded DNA specific endodeoxyribonuclease activity
has related synonym: ssDNA-specific endodeoxyribonuclease activity
type: Class
subclass of: endodeoxyribonuclease activity

phosphopyruvate hydratase complex
IAO_0000115: A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.
has exact synonym: enolase complex
type: Class
subclass of: part-of-parent-5829
subclass of: GO_1902494

lactase activity
IAO_0000115: Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.
has exact synonym: lactose galactohydrolase activity
has related synonym: lactase-phlorizin hydrolase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

alpha-glucoside transport
IAO_0000115: The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.
type: Class
subclass of: GO_0042946

regulation of DNA recombination
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
type: Class
subclass of: GO_0051052

regulation of mitotic recombination
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
has related synonym: regulation of recombination within rDNA repeats
type: Class
subclass of: regulation of DNA recombination

obsolete negative regulation of recombination within rDNA repeats
IAO_0000115: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.
type: Class
subclass of: ObsoleteClass

mitotic spindle elongation
IAO_0000115: The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.
has exact synonym: spindle elongation during mitosis
type: Class
subclass of: part-of-parent-278
subclass of: part-of-parent-70
subclass of: part-of-parent-7052
subclass of: GO_0051231
subclass of: GO_1903047

maltose metabolic process
IAO_0000115: The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.
has exact synonym: malt sugar metabolic process
has exact synonym: malt sugar metabolism
has exact synonym: maltose metabolism
type: Class
subclass of: GO_0005984

maltose biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).
has exact synonym: malt sugar biosynthesis
has exact synonym: malt sugar biosynthetic process
has exact synonym: maltose anabolism
has exact synonym: maltose biosynthesis
has exact synonym: maltose formation
has exact synonym: maltose synthesis
type: Class
subclass of: maltose metabolic process
subclass of: GO_0046351

maltose catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).
has exact synonym: malt sugar catabolic process
has exact synonym: malt sugar catabolism
has exact synonym: maltose breakdown
has exact synonym: maltose degradation
has related synonym: maltose hydrolysis
type: Class
subclass of: maltose metabolic process
subclass of: GO_0046352

alpha-1,2-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.
type: Class
subclass of: mannosyltransferase activity

ribosomal large subunit assembly
IAO_0000115: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
has related synonym: 50S ribosomal subunit assembly
has related synonym: 60S ribosomal subunit assembly
type: Class
subclass of: part-of-parent-42255
subclass of: part-of-parent-42273
subclass of: GO_0022618

ribosomal small subunit assembly
IAO_0000115: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
has related synonym: 30S ribosomal subunit assembly
has related synonym: 40S ribosomal subunit assembly
type: Class
subclass of: part-of-parent-42255
subclass of: part-of-parent-42274
subclass of: GO_0022618

mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
type: Class
subclass of: part-of-parent-97502
subclass of: GO_0016758

mannosylphosphate transferase activity
IAO_0000115: Catalysis of the transfer of a mannosylphosphate group from one compound to another.
type: Class
subclass of: GO_0016740

cell wall mannoprotein biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
has exact synonym: cell wall mannoprotein anabolism
has exact synonym: cell wall mannoprotein biosynthesis
has exact synonym: cell wall mannoprotein formation
has exact synonym: cell wall mannoprotein synthesis
type: Class
subclass of: GO_0006057
subclass of: GO_0031506

alpha-1,3-mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.
type: Class
subclass of: mannosyltransferase activity

adenine deaminase activity
IAO_0000115: Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3.
has exact synonym: ADase activity
has exact synonym: adenase activity
has exact synonym: adenine aminase activity
has exact synonym: adenine aminohydrolase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

acyl binding
IAO_0000115: Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
has related synonym: acyl-CoA or acyl binding
type: Class
subclass of: GO_0005488

acyl carrier activity
IAO_0000115: Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.
has exact synonym: ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
type: Class
subclass of: part-of-parent-6633
subclass of: GO_0044620
subclass of: GO_0140414

very long-chain fatty acid metabolic process
IAO_0000115: The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
has exact synonym: very long chain fatty acid metabolic process
has exact synonym: very-long-chain fatty acid metabolic process
has exact synonym: very-long-chain fatty acid metabolism
type: Class
subclass of: GO_0006631

obsolete plasma membrane long-chain fatty acid transporter
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

transition metal ion transport
IAO_0000115: The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
has exact synonym: transition metal transport
type: Class
subclass of: GO_0030001

obsolete ascorbate stabilization
IAO_0000115: OBSOLETE. The reduction of the ascorbate free radical to a stable form.
type: Class
subclass of: ObsoleteClass

autophagosome assembly
IAO_0000115: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
has exact synonym: autophagic vacuole assembly
has exact synonym: autophagosome biosynthesis
has exact synonym: autophagosome formation
has related synonym: PAS formation
has related synonym: autophagic vacuole formation
type: Class
subclass of: GO_0070925
subclass of: GO_1905037

obsolete Rieske iron-sulfur protein
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

peptidyltransferase activity
IAO_0000115: Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2).
has exact synonym: peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity
type: Class
subclass of: part-of-parent-6412
subclass of: GO_0016755

tRNA binding
IAO_0000115: Interacting selectively and non-covalently with transfer RNA.
has related synonym: base pairing with tRNA
replaces: GO_0000946
type: Class
subclass of: RNA binding

urea cycle
IAO_0000115: The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
has exact synonym: ornithine cycle
has exact synonym: urea biosynthesis
has exact synonym: urea biosynthetic process
replaces: GO_0006594
replaces: GO_0006871
type: Class
subclass of: GO_0019627
subclass of: GO_0043604
subclass of: GO_1901566

obsolete urea cycle intermediate metabolic process
IAO_0000115: OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
type: Class
subclass of: ObsoleteClass

citrulline metabolic process
IAO_0000115: The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
has exact synonym: citrulline metabolism
type: Class
subclass of: GO_1901605

argininosuccinate metabolic process
IAO_0000115: The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.
has exact synonym: argininosuccinate metabolism
type: Class
subclass of: GO_0006575
subclass of: GO_0072350
subclass of: GO_1901605

ribosomal subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
has exact synonym: ribosomal subunit export from cell nucleus
has exact synonym: ribosomal subunit export out of nucleus
has exact synonym: ribosomal subunit transport from nucleus to cytoplasm
has exact synonym: ribosomal subunit-nucleus export
has related synonym: ribosome export from nucleus
type: Class
subclass of: part-of-parent-42254
subclass of: GO_0033750
subclass of: GO_0051656
subclass of: GO_0071428

ribosomal large subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
has exact synonym: ribosomal large subunit export from cell nucleus
has exact synonym: ribosomal large subunit export out of nucleus
has exact synonym: ribosomal large subunit transport from nucleus to cytoplasm
has exact synonym: ribosomal large subunit-nucleus export
has related synonym: 50S ribosomal subunit export from nucleus
has related synonym: 60S ribosomal subunit export from nucleus
replaces: GO_0000057
type: Class
subclass of: ribosomal subunit export from nucleus

ribosomal small subunit export from nucleus
IAO_0000115: The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
has exact synonym: ribosomal small subunit export from cell nucleus
has exact synonym: ribosomal small subunit export out of nucleus
has exact synonym: ribosomal small subunit transport from nucleus to cytoplasm
has exact synonym: ribosomal small subunit-nucleus export
has related synonym: 30S ribosomal subunit export from nucleus
has related synonym: 40S ribosomal subunit export from nucleus
replaces: GO_0000058
type: Class
subclass of: ribosomal subunit export from nucleus

obsolete protein import into nucleus, docking
IAO_0000115: OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex.
type: Class
subclass of: ObsoleteClass

obsolete protein import into nucleus, translocation
IAO_0000115: OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
type: Class
subclass of: ObsoleteClass

obsolete protein import into nucleus, substrate release
IAO_0000115: OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex.
type: Class
subclass of: ObsoleteClass

fatty-acyl-CoA binding
IAO_0000115: Interacting selectively and non-covalently with a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
has exact synonym: fatty-acyl-coenzyme A binding
has related synonym: fatty-acyl binding
type: Class
subclass of: GO_0120227
subclass of: GO_1901567

L-ornithine transmembrane transporter activity
IAO_0000115: Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.
has related synonym: L-ornithine transporter activity
has related synonym: histidine/arginine/lysine/ornithine porter activity
type: Class
subclass of: part-of-parent-1903352
subclass of: GO_0008324
subclass of: GO_0015179

obsolete DNA replication and chromosome cycle
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

mitotic sister chromatid segregation
IAO_0000115: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
has exact synonym: mitotic chromosome segregation
has related synonym: mitotic sister-chromatid adhesion release
replaces: GO_0016359
type: Class
subclass of: part-of-parent-140014
subclass of: sister chromatid segregation
subclass of: GO_1903047

obsolete M phase specific microtubule process
IAO_0000115: OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle.
type: Class
subclass of: ObsoleteClass

initial mitotic spindle pole body separation
IAO_0000115: The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB.
replaces: GO_0030475
type: Class
subclass of: part-of-parent-1905047
subclass of: part-of-parent-61804
subclass of: GO_0110100
subclass of: GO_1903047

cell cycle checkpoint
IAO_0000115: A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
has related synonym: G1/S checkpoint
has related synonym: G1/S transition checkpoint
has related synonym: G2/M checkpoint
has related synonym: G2/M transition checkpoint
replaces: GO_0031576
replaces: GO_0071779
type: Class
subclass of: GO_0009987
subclass of: GO_0045786

DNA replication checkpoint
IAO_0000115: A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
type: Class
subclass of: GO_0031570

DNA damage checkpoint
IAO_0000115: A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
has related synonym: DNA damage response, signal transduction resulting in cell cycle arrest
type: Class
subclass of: GO_0006974
subclass of: GO_0031570

obsolete cytokinesis after mitosis checkpoint
IAO_0000115: OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis.
type: Class
subclass of: ObsoleteClass

regulation of cyclin-dependent protein serine/threonine kinase activity
IAO_0000115: Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
has exact synonym: regulation of CDK activity
has related synonym: regulation of cyclin-dependent protein kinase activity
type: Class
subclass of: GO_0071900
subclass of: GO_1904029

mitotic G1 phase
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
has exact synonym: G1 phase of mitotic cell cycle
type: Class
subclass of: part-of-parent-51329
subclass of: GO_0051318

G1/S transition of mitotic cell cycle
IAO_0000115: The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
type: Class
subclass of: part-of-parent-278
subclass of: GO_0044772
subclass of: GO_0044843

regulation of transcription involved in G1/S transition of mitotic cell cycle
IAO_0000115: Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
type: Class
subclass of: part-of-parent-82
subclass of: GO_0006355
subclass of: GO_1903047

mitotic S phase
IAO_0000115: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
has exact synonym: S phase of mitotic cell cycle
has exact synonym: S-phase of mitotic cell cycle
type: Class
subclass of: part-of-parent-51329
subclass of: GO_0051320

mitotic G2 phase
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
has exact synonym: G2 phase of mitotic cell cycle
type: Class
subclass of: part-of-parent-51329
subclass of: GO_0051319

G2/M transition of mitotic cell cycle
IAO_0000115: The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
has exact synonym: mitotic G2/M transition
type: Class
subclass of: part-of-parent-278
subclass of: GO_0044772
subclass of: GO_0044839

mitotic M phase
IAO_0000115: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
has exact synonym: M phase of mitotic cell cycle
has exact synonym: M-phase of mitotic cell cycle
type: Class
subclass of: M phase
subclass of: GO_0098763

mitotic prophase
IAO_0000115: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
type: Class
subclass of: part-of-parent-87
subclass of: GO_0051324

mitotic metaphase
IAO_0000115: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
type: Class
subclass of: part-of-parent-87
subclass of: GO_0051323

mitotic anaphase
IAO_0000115: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.
type: Class
subclass of: part-of-parent-87
subclass of: GO_0051322

mitotic anaphase A
IAO_0000115: The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.
type: Class
subclass of: mitotic anaphase

mitotic anaphase B
IAO_0000115: The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.
type: Class
subclass of: mitotic anaphase

mitotic telophase
IAO_0000115: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
type: Class
subclass of: part-of-parent-87
subclass of: GO_0051326

obsolete septin assembly and septum formation
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

S-adenosyl-L-methionine transmembrane transporter activity
IAO_0000115: Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
has exact synonym: S-adenosyl methionine permease activity
has exact synonym: S-adenosyl methionine transporter activity
has exact synonym: S-adenosylmethionine permease activity
has exact synonym: S-adenosylmethionine transmembrane transporter activity
has exact synonym: SAM transmembrane transporter activity
has related synonym: S-adenosylmethionine transporter activity
replaces: GO_0015177
type: Class
subclass of: part-of-parent-1901962
subclass of: GO_1901682

sulfur amino acid metabolic process
IAO_0000115: The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid metabolism
has exact synonym: sulphur amino acid metabolic process
has exact synonym: sulphur amino acid metabolism
type: Class
subclass of: GO_0006520
subclass of: GO_0006790

sulfur amino acid biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid anabolism
has exact synonym: sulfur amino acid biosynthesis
has exact synonym: sulfur amino acid formation
has exact synonym: sulfur amino acid synthesis
has exact synonym: sulphur amino acid biosynthesis
has exact synonym: sulphur amino acid biosynthetic process
type: Class
subclass of: sulfur amino acid metabolic process
subclass of: GO_0008652
subclass of: GO_0044272

sulfur amino acid catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.
has exact synonym: sulfur amino acid breakdown
has exact synonym: sulfur amino acid catabolism
has exact synonym: sulfur amino acid degradation
has exact synonym: sulphur amino acid catabolic process
has exact synonym: sulphur amino acid catabolism
type: Class
subclass of: sulfur amino acid metabolic process
subclass of: GO_0009063
subclass of: GO_0044273

sulfur amino acid transmembrane transporter activity
IAO_0000115: Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives.
has exact synonym: sulphur amino acid transmembrane transporter activity
has related synonym: sulfur amino acid transporter activity
has related synonym: sulphur amino acid transporter activity
type: Class
subclass of: GO_0015171
subclass of: GO_1901682

S-methylmethionine transmembrane transporter activity
IAO_0000115: Enables the transfer of S-methylmethionine from one side of a membrane to the other.
has exact synonym: S-methylmethionine permease activity
has related synonym: S-methylmethionine transporter activity
replaces: GO_0015178
type: Class
subclass of: part-of-parent-15806
subclass of: GO_0072349
subclass of: GO_1901682

sulfur amino acid transport
IAO_0000115: The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: sulphur amino acid transport
type: Class
subclass of: GO_0006865
subclass of: GO_0072348

L-methionine secondary active transmembrane transporter activity
IAO_0000115: Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
has related synonym: L-methionine porter activity
type: Class
subclass of: GO_0005294
subclass of: GO_0015191
subclass of: GO_1901680

sulfate assimilation
IAO_0000115: The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.
has exact synonym: sulphate assimilation
has related synonym: sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor
has related synonym: sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor
replaces: GO_0019378
type: Class
subclass of: GO_0006790

succinate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.
has exact synonym: fumarate dehydrogenase activity
has exact synonym: fumarate reductase activity
has exact synonym: fumaric hydrogenase activity
has exact synonym: succinate oxidoreductase activity
has exact synonym: succinate:(acceptor) oxidoreductase activity
has exact synonym: succinate:acceptor oxidoreductase activity
has exact synonym: succinic acid dehydrogenase activity
has exact synonym: succinodehydrogenase activity
has exact synonym: succinyl dehydrogenase activity
has related synonym: succinic dehydrogenase activity
replaces: GO_0019739
type: Class
subclass of: GO_0016627

histidine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
has exact synonym: histidine anabolism
has exact synonym: histidine biosynthesis
has exact synonym: histidine formation
has exact synonym: histidine synthesis
type: Class
subclass of: GO_0006547
subclass of: GO_0009073
subclass of: GO_0018130
subclass of: GO_1901607

imidazoleglycerol-phosphate synthase activity
IAO_0000115: Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+).
has exact synonym: imidazole glycerol phosphate synthase activity
has exact synonym: imidazoleglycerol phosphate synthase activity
has related synonym: glutamine amidotransferase:cyclase activity
has related synonym: imidazole-glycerol-phosphate synthase activity
type: Class
subclass of: GO_0016763

obsolete repairosome
IAO_0000115: OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage.
type: Class
subclass of: ObsoleteClass

nucleotide-excision repair complex
IAO_0000115: Any complex formed of proteins that act in nucleotide-excision repair.
has related synonym: UvrB-UvrC complex
has related synonym: UvrBC complex
type: Class
subclass of: part-of-parent-5634
subclass of: GO_1990391

nucleotide-excision repair factor 1 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
has exact synonym: NEF1 complex
has exact synonym: XPA-ERCC1-ERCC4 complex
type: Class
subclass of: nucleotide-excision repair complex

nucleotide-excision repair factor 2 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.
has exact synonym: NEF2 complex
type: Class
subclass of: nucleotide-excision repair complex

nucleotide-excision repair factor 3 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).
has exact synonym: NEF3 complex
type: Class
subclass of: nucleotide-excision repair complex

nucleotide-excision repair factor 4 complex
IAO_0000115: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.
has exact synonym: NEF4 complex
type: Class
subclass of: nucleotide-excision repair complex

obsolete regulation of transcription involved in G1 phase of mitotic cell cycle
IAO_0000115: OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle.
type: Class
subclass of: ObsoleteClass

obsolete regulation of transcription involved in S phase of mitotic cell cycle
IAO_0000115: OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle.
type: Class
subclass of: ObsoleteClass

obsolete regulation of transcription involved in G2-phase of mitotic cell cycle
IAO_0000115: OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle.
type: Class
subclass of: ObsoleteClass

regulation of transcription involved in G2/M transition of mitotic cell cycle
IAO_0000115: Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle.
has related synonym: G2/M-specific transcription in mitotic cell cycle
has related synonym: regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle
type: Class
subclass of: part-of-parent-86
subclass of: GO_0006355
subclass of: GO_1903047

histone deacetylase complex
IAO_0000115: A protein complex that possesses histone deacetylase activity.
has exact synonym: HDAC complex
type: Class
subclass of: part-of-parent-5654
subclass of: GO_1902494

RNA polymerase I transcription regulator complex
IAO_0000115: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.
has related synonym: RNA polymerase I transcription factor complex
type: Class
subclass of: part-of-parent-5730
subclass of: GO_0005667

glycerol-1-phosphatase activity
IAO_0000115: Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.
has exact synonym: alpha-glycerol phosphatase activity
has exact synonym: alpha-glycerophosphatase activity
has exact synonym: glycerol 3-phosphatase activity
has exact synonym: glycerol 3-phosphate phosphohydrolase activity
has exact synonym: glycerol-1-phosphate phosphohydrolase activity
has exact synonym: glycerol-3-phosphate phosphatase activity
type: Class
subclass of: GO_0016791

negative regulation of transcription by RNA polymerase II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
has exact synonym: down regulation of transcription from RNA polymerase II promoter
has exact synonym: down-regulation of transcription from RNA polymerase II promoter
has exact synonym: downregulation of transcription from RNA polymerase II promoter
has exact synonym: inhibition of transcription from RNA polymerase II promoter
has exact synonym: negative regulation of transcription from Pol II promoter
has exact synonym: negative regulation of transcription from RNA polymerase II promoter
has related synonym: down regulation of global transcription from RNA polymerase II promoter
has related synonym: down-regulation of global transcription from RNA polymerase II promoter
has related synonym: downregulation of global transcription from RNA polymerase II promoter
has related synonym: inhibition of global transcription from RNA polymerase II promoter
has related synonym: negative regulation of gene-specific transcription from RNA polymerase II promoter
has related synonym: negative regulation of global transcription from Pol II promoter
has related synonym: negative regulation of transcription from RNA polymerase II promoter, global
replaces: GO_0010553
replaces: GO_0045816
type: Class
subclass of: GO_0006357
subclass of: GO_0045892

histone acetyltransferase complex
IAO_0000115: A protein complex that possesses histone acetyltransferase activity.
has exact synonym: histone acetylase complex
type: Class
subclass of: part-of-parent-5654
subclass of: GO_0031248

SAGA complex
IAO_0000115: A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
has exact synonym: Spt-Ada-Gcn5-acetyltransferase complex
type: Class
subclass of: GO_0070461
subclass of: GO_1905368

PCAF complex
IAO_0000115: A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
has exact synonym: PCAF histone acetylase-associated complex
has exact synonym: SPT3-TAF9-PCAF acetylase complex
type: Class
subclass of: GO_0070461

transcription factor TFIIIB complex
IAO_0000115: A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
type: Class
subclass of: GO_0090576

transcription factor TFIIIC complex
IAO_0000115: A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.
type: Class
subclass of: GO_0090576

flocculation
IAO_0000115: The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs.
has exact synonym: cell-cell adhesion involved in flocculation
has related synonym: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
has related synonym: flocculation via cell wall protein-carbohydrate interaction
has related synonym: flocculation via extracellular polymer
replaces: GO_0000501
replaces: GO_0032128
replaces: GO_0043689
replaces: GO_0043690
type: Class
subclass of: GO_0051703
subclass of: GO_0098610

incipient cellular bud site
IAO_0000115: The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
type: Class
subclass of: part-of-parent-5622
subclass of: GO_0110165

establishment of mitotic spindle orientation
IAO_0000115: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
has exact synonym: establishment of spindle orientation involved in mitotic cell cycle
has exact synonym: mitotic spindle orientation
has exact synonym: orienting of mitotic spindle
has related synonym: establishment of spindle orientation during mitosis
replaces: GO_0030607
replaces: GO_0030609
type: Class
subclass of: part-of-parent-278
subclass of: GO_0040001
subclass of: GO_0051294

polarisome
IAO_0000115: Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.
type: Class
subclass of: part-of-parent-30427
subclass of: part-of-parent-5938
subclass of: GO_0032991

mannan polymerase complex
IAO_0000115: A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.
has exact synonym: alpha-1,6-mannosyltransferase complex
type: Class
subclass of: part-of-parent-137
subclass of: part-of-parent-30173
subclass of: GO_0031501
subclass of: GO_0098796

Golgi cis cisterna
IAO_0000115: The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
type: Class
subclass of: GO_0031985

Golgi trans cisterna
IAO_0000115: The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
has related synonym: late Golgi
type: Class
subclass of: GO_0031985

Golgi membrane
IAO_0000115: The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
type: Class
subclass of: part-of-parent-5794
subclass of: part-of-parent-98791
subclass of: GO_0098588

acylglycerone-phosphate reductase activity
IAO_0000115: Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+).
has exact synonym: 1-acyldihydroxyacetone-phosphate reductase activity
has exact synonym: 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity
has exact synonym: acyldihydroxyacetone phosphate reductase activity
has exact synonym: palmitoyl dihydroxyacetone phosphate reductase activity
has exact synonym: palmitoyl-dihydroxyacetone-phosphate reductase activity
has exact synonym: palmitoyldihydroxyacetone-phosphate reductase activity
type: Class
subclass of: GO_0016616

cellular bud neck contractile ring
IAO_0000115: A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: neck ring
type: Class
subclass of: part-of-parent-5935
subclass of: GO_0110085

cellular bud neck septin ring
IAO_0000115: A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.
type: Class
subclass of: part-of-parent-5935
subclass of: cellular bud neck septin structure
subclass of: GO_0005940
subclass of: GO_0032161

exocyst
IAO_0000115: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
has exact synonym: Sec6/8 complex
has exact synonym: exocyst complex
type: Class
subclass of: part-of-parent-5938
subclass of: GO_0099023

microfilament motor activity
IAO_0000115: Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
has exact synonym: actin filament motor activity
has exact synonym: actin-filament motor activity
has related synonym: muscle motor activity
has related synonym: myosin ATPase activity
type: Class
subclass of: motor activity

actin cortical patch assembly
IAO_0000115: Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.
type: Class
subclass of: GO_0022607
subclass of: GO_0030866
subclass of: GO_0044396

1,3-beta-D-glucan synthase complex
IAO_0000115: A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
has exact synonym: (1->3)-beta-glucan synthase complex
has exact synonym: 1,3-beta-glucan synthase complex
type: Class
subclass of: GO_0098797
subclass of: GO_1990234

SNARE binding
IAO_0000115: Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
has exact synonym: SNAP receptor binding
type: Class
subclass of: GO_0005515

recombinase activity
IAO_0000115: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
has related synonym: strand transferase
type: Class
subclass of: part-of-parent-6310
subclass of: GO_0140097

ubiquitin ligase complex
IAO_0000115: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
type: Class
subclass of: part-of-parent-5622
subclass of: GO_1990234

nuclear ubiquitin ligase complex
IAO_0000115: A ubiquitin ligase complex found in the nucleus.
type: Class
subclass of: ubiquitin ligase complex
subclass of: part-of-parent-5634

cytoplasmic ubiquitin ligase complex
IAO_0000115: A ubiquitin ligase complex found in the cytoplasm.
type: Class
subclass of: ubiquitin ligase complex
subclass of: part-of-parent-5737

rRNA modification
IAO_0000115: The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
has related synonym: rRNA editing
replaces: GO_0016548
type: Class
subclass of: GO_0006364
subclass of: GO_0009451

phosphorelay sensor kinase activity
IAO_0000115: Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
has related synonym: two-component sensor activity
has related synonym: two-component sensor molecule
has related synonym: two-component system sensor activity
type: Class
subclass of: part-of-parent-160
subclass of: part-of-parent-23014
subclass of: protein histidine kinase activity
subclass of: GO_0140299

phosphorelay response regulator activity
IAO_0000115: Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
has related synonym: two-component response regulator activity
type: Class
subclass of: part-of-parent-160
subclass of: GO_0060089

protein phosphatase type 2A complex
IAO_0000115: A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
has related synonym: protein phosphatase 2 complex
type: Class
subclass of: part-of-parent-5622
subclass of: GO_0008287

phosphorelay signal transduction system
IAO_0000115: A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
has exact synonym: histidyl-aspartyl phosphorelay
has related synonym: phosphorelay signal transduction system
type: Class
subclass of: GO_0035556

osmosensory signaling MAPK cascade
IAO_0000115: A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K.
has exact synonym: MAPK cascade involved in osmosensory signaling pathway
has exact synonym: MAPKKK cascade during osmolarity sensing
has exact synonym: MAPKKK cascade involved in osmosensory signaling pathway
has exact synonym: MAPKKK cascade involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, MAPKKK cascade
has related synonym: High Osmolarity Glycerol (HOG) MAPK pathway
has related synonym: Hog1 MAPK pathway
has related synonym: Hog1/Sty1 stress-activated MAPK cascade
type: Class
subclass of: GO_0051403

tryptophan biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.
has exact synonym: aromatic amino acid family biosynthetic process, anthranilate pathway
has exact synonym: tryptophan anabolism
has exact synonym: tryptophan biosynthesis
has exact synonym: tryptophan formation
has exact synonym: tryptophan synthesis
replaces: GO_0009096
type: Class
subclass of: GO_0006568
subclass of: GO_0009073
subclass of: GO_0046219
subclass of: GO_1901607

protein phosphatase type 1 complex
IAO_0000115: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
type: Class
subclass of: part-of-parent-5737
subclass of: GO_0008287

MAPK cascade
IAO_0000115: An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
has exact synonym: MAP kinase cascade
has exact synonym: MAP kinase kinase kinase cascade
has exact synonym: MAPK signal transduction
has exact synonym: MAPKKK cascade
has exact synonym: mitogen-activated protein kinase cascade
has related synonym: ERK/MAPK cascade
has related synonym: MAPK signaling
has related synonym: MAPK signalling
has related synonym: MAPKKK cascade during sporulation
type: Class
subclass of: GO_0023014
subclass of: GO_0035556

nucleotide binding
IAO_0000115: Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
type: Class
subclass of: GO_0036094
subclass of: GO_1901265

activation of MAPKKK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing.
has exact synonym: activation of MAP kinase kinase kinase activity during osmolarity sensing
has exact synonym: activation of MAPKKK activity during osmolarity sensing
has exact synonym: activation of MAPKKK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, activation of MAP kinase kinase kinase activity
has exact synonym: osmolarity sensing, activation of MAPKKK activity
type: Class
subclass of: part-of-parent-7231
subclass of: activation of MAPKKK activity

activation of MAPKK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing.
has exact synonym: activation of MAP kinase kinase activity during osmolarity sensing
has exact synonym: activation of MAPKK activity during osmolarity sensing
has exact synonym: activation of MAPKK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, activation of MAP kinase kinase activity
has exact synonym: osmolarity sensing, activation of MAPKK activity
has related synonym: activation of Pbs2 kinase
replaces: GO_0007233
type: Class
subclass of: part-of-parent-7231
subclass of: activation of MAPKK activity

activation of MAPK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing.
has exact synonym: activation of MAPK activity during osmolarity sensing
has exact synonym: activation of MAPK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, activation of MAPK activity
type: Class
subclass of: part-of-parent-7231
subclass of: activation of MAPK activity

sphingosine hydroxylase activity
IAO_0000115: Catalysis of the hydroxylation of sphingolipid long chain bases.
type: Class
subclass of: GO_0016491

ribonuclease MRP activity
IAO_0000115: Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.
has exact synonym: RNase MRP
type: Class
subclass of: ribonuclease activity

ribonuclease MRP complex
IAO_0000115: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
has exact synonym: RNase MRP complex
has exact synonym: ribonuclease mitochondrial RNA processing complex
type: Class
subclass of: GO_0005732
subclass of: GO_1902494

inactivation of MAPK activity involved in osmosensory signaling pathway
IAO_0000115: Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing.
has exact synonym: inactivation of MAPK activity during osmolarity sensing
has exact synonym: inactivation of MAPK activity involved in osmosensory signalling pathway
has exact synonym: osmolarity sensing, inactivation of MAPK
has exact synonym: osmolarity sensing, termination of MAPK activity
has exact synonym: termination of MAPK activity during osmolarity sensing
type: Class
subclass of: part-of-parent-7231
subclass of: inactivation of MAPK activity

obsolete inactivation of MAPK (mating sensu Saccharomyces)
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.
type: Class
subclass of: ObsoleteClass

3'-5'-exoribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
has exact synonym: 3'-5' exoribonuclease activity
type: Class
subclass of: GO_0008408
subclass of: GO_0016896

nuclear exosome (RNase complex)
IAO_0000115: A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
has exact synonym: eukaryotic exosome multienzyme ribonuclease complex
has exact synonym: nuclear exosome (ribonuclease complex)
has exact synonym: nuclear exosome multienzyme ribonuclease complex
type: Class
subclass of: part-of-parent-31981
subclass of: part-of-parent-5634
subclass of: exosome (RNase complex)

cytoplasmic exosome (RNase complex)
IAO_0000115: A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
has exact synonym: cytoplasmic exosome (ribonuclease complex)
has exact synonym: cytoplasmic exosome multienzyme ribonuclease complex
has exact synonym: prokaryotic exosome multienzyme ribonuclease complex
type: Class
subclass of: part-of-parent-5737
subclass of: exosome (RNase complex)

exosome (RNase complex)
IAO_0000115: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
has exact synonym: exosome (ribonucleasease complex)
has exact synonym: exosome multienzyme ribonuclease complex
type: Class
subclass of: part-of-parent-5622
subclass of: GO_1905354

rRNA (adenine-N6,N6-)-dimethyltransferase activity
IAO_0000115: Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
has exact synonym: 18S rRNA dimethylase activity
has exact synonym: S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity
has exact synonym: dimethyladenosine transferase activity
replaces: GO_0043790
type: Class
subclass of: GO_0008170
subclass of: GO_0016433

obsolete cytosolic large ribosomal subunit
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete cytosolic small ribosomal subunit
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

rDNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.
has exact synonym: ribosomal DNA binding
type: Class
subclass of: GO_1990837

rDNA heterochromatin assembly
IAO_0000115: The assembly of chromatin characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of rDNA.
has related synonym: chromatin silencing at rDNA
has related synonym: chromatin silencing at ribosomal DNA
has related synonym: heterochromatic silencing at rDNA
has related synonym: rDNA chromatin silencing
type: Class
subclass of: GO_0031507

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
IAO_0000115: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
has exact synonym: mRNA breakdown, nonsense-mediated decay
has exact synonym: mRNA catabolic process, nonsense-mediated
has exact synonym: mRNA catabolism, nonsense-mediated
has exact synonym: mRNA degradation, nonsense-mediated decay
has exact synonym: nonsense-mediated mRNA decay
has exact synonym: nuclear mRNA catabolic process, nonsense-mediated decay
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

activation of MAPKKK activity
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
has exact synonym: activation of MAP kinase kinase kinase
has exact synonym: activation of MAP3K activity
has related synonym: activation of MAPKKK activity during sporulation
has related synonym: positive regulation of MAP kinase kinase kinase activity
has related synonym: positive regulation of MAPKKK activity
type: Class
subclass of: GO_0032147
subclass of: GO_0043406

activation of MAPKK activity
IAO_0000115: The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
has exact synonym: activation of MAP kinase kinase activity
has exact synonym: activation of MAP/ERK kinase kinase
has exact synonym: activation of MAP2K activity
has related synonym: activation of MAPKK activity during sporulation
has related synonym: positive regulation of MAPKK activity
replaces: GO_0007255
type: Class
subclass of: GO_0032147
subclass of: GO_0043406

activation of MAPK activity
IAO_0000115: The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
has exact synonym: MAPK activation
has exact synonym: activation of MAP kinase
has related synonym: activation of MAPK activity during sporulation
type: Class
subclass of: GO_0032147
subclass of: GO_0043406

inactivation of MAPK activity
IAO_0000115: Any process that terminates the activity of the active enzyme MAP kinase.
has exact synonym: termination of MAPK activity
has related synonym: inactivation of MAPK during sporulation
type: Class
subclass of: GO_0043407

obsolete MAPK import into nucleus
IAO_0000115: OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation.
type: Class
subclass of: ObsoleteClass

obsolete MAPKKK cascade (pseudohyphal growth)
IAO_0000115: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth.
type: Class
subclass of: ObsoleteClass

obsolete activation of MAPKKK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth.
type: Class
subclass of: ObsoleteClass

obsolete activation of MAPKK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth.
type: Class
subclass of: ObsoleteClass

obsolete activation of MAPK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.
type: Class
subclass of: ObsoleteClass

obsolete inactivation of MAPK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.
type: Class
subclass of: ObsoleteClass

obsolete nuclear translocation of MAPK (pseudohyphal growth)
IAO_0000115: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth.
type: Class
subclass of: ObsoleteClass

cell wall integrity MAPK cascade
IAO_0000115: A MAPK cascade that contributes to cell wall organization or biogenesis.
has exact synonym: MAPK cascade involved in cell wall organization or biogenesis
has exact synonym: MAPKKK cascade involved in cell wall biogenesis
has exact synonym: cell integrity MAPK pathway
has exact synonym: cell wall biogenesis, MAPKKK cascade
has related synonym: MAPK cascade involved in cell wall biogenesis
has related synonym: Mpk1 cascade
has related synonym: PMK1-MAPK signal transduction pathway
has related synonym: Pmk1 MAPK cell integrity signaling
has related synonym: Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway
has related synonym: Slt2 cascade
type: Class
subclass of: part-of-parent-71554
subclass of: GO_0051403

activation of MAPKKK activity involved in cell wall organization or biogenesis
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis.
has exact synonym: activation of MAP kinase kinase kinase activity during cell wall biogenesis
has exact synonym: activation of MAPKKK activity involved in cell wall integrity
has exact synonym: cell wall biogenesis, activation of MAP kinase kinase kinase activity
has exact synonym: cell wall biogenesis, activation of MAPKKK activity
has related synonym: activation of MAPKKK activity involved in cell wall biogenesis
type: Class
subclass of: activation of MAPKKK activity
subclass of: part-of-parent-71554

activation of MAPKK activity involved in cell wall organization or biogenesis
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis.
has exact synonym: activation of MAP kinase kinase activity during cell wall biogenesis
has exact synonym: activation of MAPKK activity involved in cell wall integrity
has exact synonym: cell wall biogenesis, activation of MAP kinase kinase activity
has exact synonym: cell wall biogenesis, activation of MAPKK activity
has related synonym: activation of MAPKK activity involved in cell wall biogenesis
type: Class
subclass of: activation of MAPKK activity
subclass of: part-of-parent-71554

activation of MAPK activity involved in cell wall organization or biogenesis
IAO_0000115: Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
has exact synonym: activation of MAPK activity involved in cell wall integrity
has exact synonym: cell wall biogenesis, activation of MAPK activity
has related synonym: activation of MAPK activity involved in cell wall biogenesis
type: Class
subclass of: activation of MAPK activity
subclass of: part-of-parent-71554

inactivation of MAPK activity involved in cell wall organization or biogenesis
IAO_0000115: Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis.
has exact synonym: cell wall biogenesis, inactivation of MAPK activity
has exact synonym: cell wall biogenesis, termination of MAPK activity
has exact synonym: inactivation of MAPK activity involved in cell wall integrity
has exact synonym: termination of MAPK activity during cell wall biogenesis
has related synonym: inactivation of MAPK activity involved in cell wall organization or biogenesis
type: Class
subclass of: inactivation of MAPK activity
subclass of: part-of-parent-71554

obsolete MAPK import into nucleus involved in cell wall organization or biogenesis
IAO_0000115: OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis.
type: Class
subclass of: ObsoleteClass

obsolete MAPKKK cascade during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
type: Class
subclass of: ObsoleteClass

obsolete activation of MAPKKK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
type: Class
subclass of: ObsoleteClass

obsolete activation of MAPKK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
type: Class
subclass of: ObsoleteClass

obsolete activation of MAPK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
type: Class
subclass of: ObsoleteClass

obsolete inactivation of MAPK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
type: Class
subclass of: ObsoleteClass

obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
IAO_0000115: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).
type: Class
subclass of: ObsoleteClass

obsolete MAPK import into nucleus involved in osmosensory signaling pathway
IAO_0000115: OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing.
type: Class
subclass of: ObsoleteClass

protein polyubiquitination
IAO_0000115: Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
has exact synonym: protein polyubiquitinylation
has exact synonym: protein polyubiquitylation
has related synonym: polyubiquitin
type: Class
subclass of: GO_0016567

NAD+ diphosphatase activity
IAO_0000115: Catalysis of the reaction: NAD+ + H2O = AMP + NMN.
has exact synonym: NAD diphosphatase activity
has exact synonym: NAD pyrophosphatase activity
has exact synonym: NAD(+) pyrophosphatase activity
has exact synonym: NAD+ phosphohydrolase activity
has exact synonym: NAD+ pyrophosphatase activity
has exact synonym: nicotinamide adenine dinucleotide pyrophosphatase activity
has related synonym: NADH pyrophosphatase activity
has related synonym: NADP pyrophosphatase activity
type: Class
subclass of: nucleotide diphosphatase activity

obsolete protein degradation tagging activity
IAO_0000115: OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction.
type: Class
subclass of: ObsoleteClass

meiotic spindle organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
has exact synonym: meiotic spindle organisation
has exact synonym: spindle organization during meiosis
has related synonym: meiotic spindle organization and biogenesis
has related synonym: meiotic spindle stabilization
replaces: GO_0043147
type: Class
subclass of: part-of-parent-51321
subclass of: GO_0007051
subclass of: GO_1903046

tRNA-intron endonuclease activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
has exact synonym: splicing endonuclease activity
has exact synonym: tRNA splicing endonuclease activity
has exact synonym: tRNA-intron endoribonuclease activity
has exact synonym: tRNA-splicing endonuclease activity
has exact synonym: tRNATRPintron endonuclease activity
has exact synonym: transfer ribonucleate intron endoribonuclease activity
has exact synonym: transfer splicing endonuclease activity
type: Class
subclass of: tRNA-specific ribonuclease activity
subclass of: GO_0016892

tRNA-intron endonuclease complex
IAO_0000115: A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
has exact synonym: SEN complex
has exact synonym: tRNA splicing endonuclease complex
type: Class
subclass of: part-of-parent-5634
subclass of: GO_1902555

tRNA 2'-phosphotransferase activity
IAO_0000115: Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.
has exact synonym: 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity
has exact synonym: 2'-phospho-tRNA:NAD+ phosphotransferase activity
has related synonym: 2'-phosphotransferase activity
has related synonym: Tpt1
has related synonym: Tpt1p
has related synonym: yeast 2'-phosphotransferase activity
replaces: GO_0008665
type: Class
subclass of: GO_0016773
subclass of: GO_0140101

obsolete M/G1 transition of mitotic cell cycle
IAO_0000115: OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle.
type: Class
subclass of: ObsoleteClass

DNA secondary structure binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions.
type: Class
subclass of: DNA binding

obsolete vacuolar hydrogen-transporting ATPase
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

vacuolar proton-transporting V-type ATPase, V0 domain
IAO_0000115: The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
has exact synonym: vacuolar hydrogen ion-transporting ATPase V0 domain
type: Class
subclass of: part-of-parent-5773
subclass of: GO_0033179

vacuolar proton-transporting V-type ATPase, V1 domain
IAO_0000115: The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
has exact synonym: vacuolar hydrogen ion-transporting ATPase V1 domain
type: Class
subclass of: part-of-parent-16471
subclass of: part-of-parent-5773
subclass of: GO_0033180

plasma membrane proton-transporting V-type ATPase, V0 domain
IAO_0000115: The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.
has exact synonym: plasma membrane hydrogen ion-transporting ATPase V0 domain
type: Class
subclass of: part-of-parent-33181
subclass of: part-of-parent-5886
subclass of: part-of-parent-5887
subclass of: GO_0033179
subclass of: GO_0098797

plasma membrane proton-transporting V-type ATPase, V1 domain
IAO_0000115: The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.
has exact synonym: plasma membrane hydrogen ion-transporting ATPase V1 domain
type: Class
subclass of: part-of-parent-33181
subclass of: part-of-parent-5886
subclass of: part-of-parent-5887
subclass of: GO_0033180
subclass of: GO_0098797

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
IAO_0000115: Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.
has exact synonym: N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity
has exact synonym: PNGase
has related synonym: N-glycanase activity
has related synonym: N-oligosaccharide glycopeptidase activity
has related synonym: PNGase A
has related synonym: PNGase F
has related synonym: glycopeptidase activity
has related synonym: glycopeptide N-glycosidase activity
has related synonym: jack-bean glycopeptidase
has related synonym: peptide:N-glycanase
type: Class
subclass of: GO_0016811

N-acetylglucosaminylphosphatidylinositol deacetylase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane.
has exact synonym: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity
has exact synonym: GlcNAc-PI de-N-acetylase activity
has exact synonym: GlcNAc-PI deacetylase activity
has exact synonym: N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity
has exact synonym: N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity
has exact synonym: acetylglucosaminylphosphatidylinositol deacetylase activity
type: Class
subclass of: GO_0016811
subclass of: GO_0019213

microtubule cytoskeleton organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
has exact synonym: microtubule cytoskeleton organisation
has exact synonym: microtubule dynamics
has related synonym: microtubule cytoskeleton organization and biogenesis
type: Class
subclass of: GO_0007010
subclass of: GO_0007017

oxaloacetate secondary active transmembrane transporter activity
IAO_0000115: Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
has related synonym: oxaloacetate carrier activity
type: Class
subclass of: GO_0015131
subclass of: GO_0015291
subclass of: GO_0022853

nuclear chromosome
IAO_0000115: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
has related synonym: nuclear interphase chromosome
type: Class
subclass of: part-of-parent-31981
subclass of: part-of-parent-5634
subclass of: GO_0005694

cytoplasmic chromosome
IAO_0000115: A chromosome found in the cytoplasm.
has related synonym: cytoplasmic interphase chromosome
type: Class
subclass of: part-of-parent-5737
subclass of: GO_0005694

obsolete nuclear mitotic chromosome
IAO_0000115: OBSOLETE. A chromosome found in the nucleus during mitosis.
type: Class
subclass of: ObsoleteClass

obsolete cytoplasmic mitotic chromosome
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm during mitosis.
type: Class
subclass of: ObsoleteClass

obsolete nuclear interphase chromosome
IAO_0000115: OBSOLETE. A chromosome found in the nucleus during interphase.
type: Class
subclass of: ObsoleteClass

obsolete cytoplasmic interphase chromosome
IAO_0000115: OBSOLETE. A chromosome found in the cytoplasm during interphase.
type: Class
subclass of: ObsoleteClass

phosphoethanolamine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate.
has exact synonym: S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity
has exact synonym: phosphoethanolamine methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008757

astral microtubule
IAO_0000115: Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
type: Class
subclass of: part-of-parent-5818
subclass of: GO_0005876
subclass of: GO_0005881

mitotic prometaphase
IAO_0000115: The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
type: Class
subclass of: GO_0098763

leptotene
IAO_0000115: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.
type: Class
subclass of: part-of-parent-7128
subclass of: GO_0098764

zygotene
IAO_0000115: The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.
type: Class
subclass of: part-of-parent-7128
subclass of: GO_0098764

pachytene
IAO_0000115: The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.
type: Class
subclass of: part-of-parent-7128
subclass of: GO_0098764

diplotene
IAO_0000115: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.
type: Class
subclass of: part-of-parent-7128
subclass of: GO_0098764

diakinesis
IAO_0000115: The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.
type: Class
subclass of: part-of-parent-7128
subclass of: GO_0098764

pericentriolar material
IAO_0000115: A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
type: Class
subclass of: part-of-parent-5813
subclass of: GO_0110165

commitment complex
IAO_0000115: A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.
has related synonym: mammalian spliceosomal E complex
has related synonym: mammalian spliceosomal complex E
has related synonym: yeast spliceosomal complex CC
type: Class
subclass of: GO_0005684

spliceosomal tri-snRNP complex assembly
IAO_0000115: The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
has exact synonym: assembly of spliceosomal tri-snRNP
has exact synonym: spliceosomal tri-snRNP assembly
has related synonym: assembly of spliceosomal tri-snRNP U4/U6.U5
has related synonym: assembly of spliceosomal tri-snRNP U4atac/U6atac.U5
has related synonym: snRNP recycling
has related synonym: spliceosomal tri-snRNP U4/U6.U5 assembly
has related synonym: spliceosomal tri-snRNP U4atac/U6atac.U5 assembly
replaces: GO_0000351
replaces: GO_0000355
type: Class
subclass of: spliceosomal snRNP assembly

spliceosomal complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
has related synonym: spliceosome assembly
type: Class
subclass of: part-of-parent-398
subclass of: GO_0022618

delta24(24-1) sterol reductase activity
IAO_0000115: Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH.
has exact synonym: C-24(28) sterol reductase activity
has exact synonym: D24(24-1)-sterol reductase activity
has exact synonym: delta24(241)-sterol reductase activity
has exact synonym: ergosterol:NADP+ delta24(241)-oxidoreductase activity
has exact synonym: sterol Delta(24(28))-methylene reductase activity
has exact synonym: sterol Delta(24(28))-reductase activity
has exact synonym: sterol delta-24(28) methylene reductase activity
has exact synonym: sterol delta-24(28) reductase activity
has exact synonym: sterol delta24(28)-methylene reductase activity
has exact synonym: sterol delta24(28)-reductase activity
type: Class
subclass of: GO_0016628

C-8 sterol isomerase activity
IAO_0000115: Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.
has exact synonym: delta-8-delta-7 sterol isomerase activity
type: Class
subclass of: GO_0016863

C-5 sterol desaturase activity
IAO_0000115: Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
has exact synonym: sterol-C5-desaturase activity
type: Class
subclass of: GO_0016717
subclass of: GO_0070704

C-22 sterol desaturase activity
IAO_0000115: Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
type: Class
subclass of: GO_0016717
subclass of: GO_0070704

lanosterol synthase activity
IAO_0000115: Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
has exact synonym: (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
has exact synonym: 2,3-epoxysqualene lanosterol cyclase activity
has exact synonym: 2,3-epoxysqualene--lanosterol cyclase activity
has exact synonym: 2,3-epoxysqualene-lanosterol cyclase activity
has exact synonym: 2,3-oxidosqualene-lanosterol cyclase activity
has exact synonym: OSC
has exact synonym: lanosterol 2,3-oxidosqualene cyclase activity
has exact synonym: oxidosqualene--lanosterol cyclase activity
has exact synonym: oxidosqualene-lanosterol cyclase activity
has exact synonym: oxidosqualene:lanosterol cyclase activity
has exact synonym: squalene 2,3-epoxide:lanosterol cyclase activity
has exact synonym: squalene-2,3-oxide-lanosterol cyclase activity
has related synonym: 2,3-oxidosqualene sterol cyclase activity
has related synonym: squalene epoxidase-cyclase activity
type: Class
subclass of: GO_0031559

C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
IAO_0000115: Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
has exact synonym: 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
has related synonym: 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
has related synonym: 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
has related synonym: 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
has related synonym: C-3 sterol dehydrogenase (C-4 decarboxylase) activity
has related synonym: C-3 sterol dehydrogenase activity
has related synonym: sterol 4alpha-carboxylic decarboxylase activity
has related synonym: sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
has related synonym: sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
type: Class
subclass of: GO_0016616

3-keto sterol reductase activity
IAO_0000115: Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
has exact synonym: 3-KSR activity
has exact synonym: 3-keto-steroid reductase activity
has related synonym: 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
replaces: GO_0050576
type: Class
subclass of: GO_0016616

C-4 methylsterol oxidase activity
IAO_0000115: Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.
has exact synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)
has exact synonym: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
has exact synonym: 4-methylsterol oxidase activity
has related synonym: methylsterol hydroxylase activity
has related synonym: methylsterol monooxygenase activity
type: Class
subclass of: GO_0016709

allantoin metabolic process
IAO_0000115: The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.
has exact synonym: allantoin metabolism
type: Class
subclass of: GO_0043603
subclass of: GO_0046483
subclass of: GO_1901360
subclass of: GO_1901564

allantoin catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.
has exact synonym: allantoin breakdown
has exact synonym: allantoin catabolism
has exact synonym: allantoin degradation
type: Class
subclass of: allantoin metabolic process
subclass of: GO_0043605
subclass of: GO_0046700
subclass of: GO_1901361
subclass of: GO_1901565

nitrilase activity
IAO_0000115: Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
has exact synonym: acetonitrilase activity
has exact synonym: benzonitrilase activity
has exact synonym: nitrile aminohydrolase activity
type: Class
subclass of: GO_0016815

obsolete isoleucine/valine:sodium symporter activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in).
type: Class
subclass of: ObsoleteClass

obsolete intracellular nucleoside transmembrane transporter activity
IAO_0000115: OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell.
type: Class
subclass of: ObsoleteClass

obsolete hydrogen-translocating V-type ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria.
type: Class
subclass of: ObsoleteClass

obsolete sodium-translocating V-type ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria.
type: Class
subclass of: ObsoleteClass

mitochondrial chromosome
IAO_0000115: A chromosome found in the mitochondrion of a eukaryotic cell.
has related synonym: mitochondrial DNA
has related synonym: mitochondrial genome
has related synonym: mtDNA
type: Class
subclass of: cytoplasmic chromosome
subclass of: part-of-parent-42645
subclass of: part-of-parent-5739

obsolete heterotrimeric G-protein GTPase, alpha-subunit
IAO_0000115: OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity.
type: Class
subclass of: ObsoleteClass

obsolete heterotrimeric G-protein GTPase, beta-subunit
IAO_0000115: OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit.
type: Class
subclass of: ObsoleteClass

obsolete heterotrimeric G-protein GTPase, gamma-subunit
IAO_0000115: OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit.
type: Class
subclass of: ObsoleteClass

mitochondrial fission
IAO_0000115: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
has exact synonym: mitochondrial division
has related synonym: mitochondrial proliferation
type: Class
subclass of: GO_0007005
subclass of: GO_0048285

obsolete cell fraction
IAO_0000115: OBSOLETE. A generic term for parts of cells prepared by disruptive biochemical techniques.
type: Class
subclass of: ObsoleteClass

peroxisome targeting sequence binding
IAO_0000115: Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome.
has exact synonym: PTS binding
has related synonym: PTS receptor
has related synonym: peroxisome targeting signal receptor
replaces: GO_0005051
type: Class
subclass of: GO_0005048

toxin export channel activity
IAO_0000115: Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
type: Class
subclass of: GO_0015288
subclass of: GO_0019534

peptidoglycan metabolic process
IAO_0000115: The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.
has exact synonym: murein metabolic process
has exact synonym: murein metabolism
has exact synonym: peptidoglycan metabolism
replaces: GO_0009284
type: Class
subclass of: GO_0030203

polysaccharide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
has exact synonym: glycan biosynthesis
has exact synonym: glycan biosynthetic process
has exact synonym: polysaccharide anabolism
has exact synonym: polysaccharide biosynthesis
has exact synonym: polysaccharide formation
has exact synonym: polysaccharide synthesis
type: Class
subclass of: GO_0005976
subclass of: GO_0009059
subclass of: GO_0016051

polysaccharide catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
has exact synonym: polysaccharide breakdown
has exact synonym: polysaccharide catabolism
has exact synonym: polysaccharide degradation
has related synonym: multicellular organismal polysaccharide catabolic process
replaces: GO_0044244
type: Class
subclass of: GO_0005976
subclass of: GO_0009057
subclass of: GO_0016052

mitochondrial proton-transporting ATP synthase, stator stalk
IAO_0000115: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.
has exact synonym: mitochondrial proton-transporting ATP synthase, peripheral stalk
type: Class
subclass of: part-of-parent-276
subclass of: part-of-parent-5739
subclass of: GO_0045265
subclass of: GO_0098800

mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
IAO_0000115: The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.
has related synonym: hydrogen-transporting ATP synthase, F1 sector
has related synonym: proton-transporting ATP synthase complex, catalytic core F(1)
type: Class
subclass of: part-of-parent-5739
subclass of: part-of-parent-5753
subclass of: GO_0045261
subclass of: GO_0098800

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
IAO_0000115: All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.
type: Class
subclass of: part-of-parent-5739
subclass of: part-of-parent-5753
subclass of: GO_0045263
subclass of: GO_0098800

[cytochrome c]-lysine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c.
has exact synonym: S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity
has exact synonym: cytochrome c (lysine) methyltransferase activity
has exact synonym: cytochrome c methyltransferase activity
has exact synonym: cytochrome c-lysine N-methyltransferase activity
has exact synonym: cytochrome c-specific protein methylase III activity
has exact synonym: cytochrome c-specific protein-lysine methyltransferase activity
type: Class
subclass of: GO_0016279

mitotic cell cycle
IAO_0000115: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has related synonym: mitosis
replaces: GO_0007067
type: Class
subclass of: GO_0007049

M phase
IAO_0000115: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
has exact synonym: M-phase
type: Class
subclass of: GO_0022403

nuclear division
IAO_0000115: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
has related synonym: karyokinesis
type: Class
subclass of: GO_0048285

mitotic cytokinesis
IAO_0000115: A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
has exact synonym: cytokinesis after mitosis
type: Class
subclass of: part-of-parent-278
subclass of: GO_0061640
subclass of: GO_1903047

cellular bud site selection
IAO_0000115: The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: bud site selection/establishment of cell polarity
type: Class
subclass of: part-of-parent-281
subclass of: GO_0030010
subclass of: GO_1903047

obsolete shmoo orientation
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

1-phosphatidylinositol-3-phosphate 5-kinase activity
IAO_0000115: Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
has exact synonym: ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity
has exact synonym: phosphatidylinositol 3-phosphate 5-kinase activity
has exact synonym: phosphatidylinositol-3-phosphate 5-kinase activity
has related synonym: type III PIP kinase activity
type: Class
subclass of: GO_0016307

alanine dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+).
has exact synonym: L-alanine dehydrogenase activity
has exact synonym: L-alanine:NAD+ oxidoreductase (deaminating)
has exact synonym: NAD-dependent alanine dehydrogenase activity
has exact synonym: NAD-linked alanine dehydrogenase activity
has exact synonym: NADH-dependent alanine dehydrogenase activity
has exact synonym: alanine oxidoreductase activity
has exact synonym: alpha-alanine dehydrogenase activity
has related synonym: AlaDH
type: Class
subclass of: GO_0016638

magnesium ion binding
IAO_0000115: Interacting selectively and non-covalently with magnesium (Mg) ions.
has exact synonym: magnesium binding
type: Class
subclass of: GO_0046872

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
IAO_0000115: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
has exact synonym: deadenylation-dependent mRNA decay
has exact synonym: mRNA breakdown, deadenylation-dependent decay
has exact synonym: mRNA catabolic process, deadenylation-dependent
has exact synonym: mRNA catabolic process, deadenylylation-dependent
has exact synonym: mRNA catabolism, deadenylation-dependent
has exact synonym: mRNA catabolism, deadenylylation-dependent
has exact synonym: mRNA degradation, deadenylation-dependent decay
has exact synonym: nuclear mRNA catabolic process, deadenylation-dependent decay
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA poly(A) tail shortening
IAO_0000115: Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
has related synonym: 3' to 5' mRNA deadenylation
has related synonym: mRNA deadenylation
has related synonym: nuclear mRNA poly(A) tail shortening
type: Class
subclass of: part-of-parent-288
subclass of: nuclear-transcribed mRNA catabolic process

deadenylation-dependent decapping of nuclear-transcribed mRNA
IAO_0000115: Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
has exact synonym: deadenylation-dependent decapping of nuclear mRNA
has exact synonym: deadenylylation-dependent decapping
type: Class
subclass of: part-of-parent-288
subclass of: nuclear-transcribed mRNA catabolic process
subclass of: GO_0110156

nuclear-transcribed mRNA catabolic process, exonucleolytic
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail.
has exact synonym: exonucleolytic degradation of mRNA
has exact synonym: mRNA breakdown, exonucleolytic
has exact synonym: mRNA degradation, exonucleolytic
has exact synonym: nuclear mRNA catabolic process, exonucleolytic
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

RNA fragment catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing.
has exact synonym: RNA fragment breakdown
has exact synonym: RNA fragment catabolism
has exact synonym: RNA fragment degradation
has related synonym: group I intron catabolic process
replaces: GO_0030452
type: Class
subclass of: GO_0006401

ferric-chelate reductase activity
IAO_0000115: Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+).
has exact synonym: Fe(II):NAD+ oxidoreductase activity
has exact synonym: NADH2:Fe3+ oxidoreductase activity
has exact synonym: NADH:Fe(3+) oxidoreductase activity
has exact synonym: NADH:Fe(3+)-EDTA reductase activity
has exact synonym: NADH:Fe3+ oxidoreductase activity
has exact synonym: NADH:Fe3+-EDTA reductase activity
has exact synonym: ferric chelate reductase activity
has related synonym: iron chelate reductase activity
type: Class
subclass of: GO_0016723

nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
IAO_0000115: A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.
has exact synonym: endonucleolytic mRNA decay
has exact synonym: mRNA breakdown, endonucleolytic cleavage-dependent decay
has exact synonym: mRNA catabolic process, endonucleolytic
has exact synonym: mRNA catabolism, endonucleolytic
has exact synonym: mRNA degradation, endonucleolytic cleavage-dependent decay
has exact synonym: nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay
type: Class
subclass of: nuclear-transcribed mRNA catabolic process

adenine nucleotide transmembrane transporter activity
IAO_0000115: Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other.
type: Class
subclass of: part-of-parent-51503
subclass of: GO_0015216

spermine transport
IAO_0000115: The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
type: Class
subclass of: GO_0006812
subclass of: GO_0015846

spermine transmembrane transporter activity
IAO_0000115: Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
type: Class
subclass of: part-of-parent-1903710
subclass of: GO_0008324
subclass of: GO_0015203

endopolyphosphatase activity
IAO_0000115: Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.
has exact synonym: polymetaphosphatase activity
has exact synonym: polyphosphate polyphosphohydrolase activity
has related synonym: metaphosphatase activity
has related synonym: polyphosphatase activity
has related synonym: polyphosphate depolymerase activity
type: Class
subclass of: GO_0016462

obsolete integral to membrane of membrane fraction
IAO_0000115: OBSOLETE. Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes.
type: Class
subclass of: ObsoleteClass

obsolete peripheral to membrane of membrane fraction
IAO_0000115: OBSOLETE. Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH.
type: Class
subclass of: ObsoleteClass

retrograde transport, vesicle recycling within Golgi
IAO_0000115: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.
has exact synonym: retrograde (vesicle recycling within Golgi) transport
type: Class
subclass of: GO_0006891

response to reactive oxygen species
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
has exact synonym: response to AOS
has exact synonym: response to ROI
has exact synonym: response to ROS
has exact synonym: response to active oxygen species
has exact synonym: response to reactive oxidative species
has exact synonym: response to reactive oxygen intermediate
type: Class
subclass of: GO_0006979
subclass of: GO_1901700

response to superoxide
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
type: Class
subclass of: response to oxygen radical

response to singlet oxygen
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.
type: Class
subclass of: response to reactive oxygen species
subclass of: GO_0010035

response to oxygen radical
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion.
type: Class
subclass of: response to reactive oxygen species
subclass of: GO_0010035

extrinsic component of vacuolar membrane
IAO_0000115: The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has exact synonym: extrinsic to vacuolar membrane
type: Class
subclass of: part-of-parent-5774
subclass of: GO_0031312

cyclin-dependent protein kinase holoenzyme complex
IAO_0000115: Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
has exact synonym: CDK holoenzyme
type: Class
subclass of: part-of-parent-5622
subclass of: GO_1902554

cytoplasmic cyclin-dependent protein kinase holoenzyme complex
IAO_0000115: Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
has related synonym: CDK holoenzyme
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex
subclass of: part-of-parent-5737

nicotinamide-nucleotide adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.
has exact synonym: ATP:NMN adenylyltransferase activity
has exact synonym: ATP:nicotinamide-nucleotide adenylyltransferase activity
has exact synonym: NAD+ diphosphorylase activity
has exact synonym: NAD+ pyrophosphorylase activity
has exact synonym: adenosine triphosphate-nicotinamide mononucleotide transadenylase activity
has related synonym: NAD(+) diphosphorylase activity
has related synonym: NAD(+) pyrophosphorylase activity
has related synonym: NMN adenylyltransferase activity
has related synonym: NMNAT activity
has related synonym: diphosphopyridine nucleotide pyrophosphorylase activity
has related synonym: nicotinamide adenine dinucleotide pyrophosphorylase activity
has related synonym: nicotinamide mononucleotide adenylyltransferase activity
type: Class
subclass of: GO_0070566

xanthine phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate.
has exact synonym: 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity
has exact synonym: XMP pyrophosphorylase activity
has exact synonym: XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity
has exact synonym: Xan phosphoribosyltransferase activity
has exact synonym: xanthine-guanine phosphoribosyltransferase activity
has exact synonym: xanthosine 5'-phosphate pyrophosphorylase activity
has exact synonym: xanthylate pyrophosphorylase activity
has exact synonym: xanthylic pyrophosphorylase activity
replaces: GO_0009043
type: Class
subclass of: GO_0106130

plastid large ribosomal subunit
IAO_0000115: The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
type: Class
subclass of: part-of-parent-9547
subclass of: organellar large ribosomal subunit

plastid small ribosomal subunit
IAO_0000115: The smaller of the two subunits of a plastid ribosome.
type: Class
subclass of: part-of-parent-9547
subclass of: organellar small ribosomal subunit

organellar ribosome
IAO_0000115: A ribosome contained within a subcellular membrane-bounded organelle.
type: Class
subclass of: part-of-parent-43226
subclass of: GO_0005840

organellar small ribosomal subunit
IAO_0000115: The smaller of the two subunits of an organellar ribosome.
type: Class
subclass of: part-of-parent-313
subclass of: GO_0015935

organellar large ribosomal subunit
IAO_0000115: The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
type: Class
subclass of: part-of-parent-313
subclass of: GO_0015934

sulfite transport
IAO_0000115: The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: sulphite transport
type: Class
subclass of: GO_0015698
subclass of: GO_0072348

sulfite transmembrane transporter activity
IAO_0000115: Enables the transfer of sulfite ions from one side of a membrane to the other.
has exact synonym: sulphite transporter activity
type: Class
subclass of: part-of-parent-316
subclass of: GO_0015103
subclass of: GO_1901682

re-entry into mitotic cell cycle
IAO_0000115: The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.
type: Class
subclass of: GO_0022402

re-entry into mitotic cell cycle after pheromone arrest
IAO_0000115: The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.
type: Class
subclass of: re-entry into mitotic cell cycle
subclass of: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion

storage vacuole
IAO_0000115: A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.
type: Class
subclass of: GO_0005773

lytic vacuole
IAO_0000115: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.
type: Class
subclass of: GO_0005773

fungal-type vacuole
IAO_0000115: A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
has exact synonym: vacuole, cell cycle-correlated morphology
type: Class
subclass of: storage vacuole
subclass of: lytic vacuole

plant-type vacuole
IAO_0000115: A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
has exact synonym: vacuole, cell cycle-independent morphology
type: Class
subclass of: GO_0005773

protein storage vacuole
IAO_0000115: A storage vacuole that contains a lytic vacuole; identified in plants.
type: Class
subclass of: storage vacuole
subclass of: plant-type vacuole

lytic vacuole within protein storage vacuole
IAO_0000115: A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole.
type: Class
subclass of: lytic vacuole
subclass of: part-of-parent-326

fungal-type vacuole lumen
IAO_0000115: The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: lumen of vacuole with cell cycle-correlated morphology
type: Class
subclass of: part-of-parent-324
subclass of: GO_0005775

fungal-type vacuole membrane
IAO_0000115: The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: membrane of vacuole with cell cycle-correlated morphology
has related synonym: fungal-type vacuolar membrane
type: Class
subclass of: part-of-parent-324
subclass of: GO_0098852

plant-type vacuole lumen
IAO_0000115: The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana.
has exact synonym: lumen of vacuole with cell cycle-independent morphology
type: Class
subclass of: part-of-parent-325
subclass of: GO_0005775

contractile vacuole
IAO_0000115: A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory.
has related synonym: central bladder
has related synonym: central vacuole
type: Class
subclass of: part-of-parent-62159
subclass of: GO_0005773
subclass of: GO_0031410

template for synthesis of G-rich strand of telomere DNA activity
IAO_0000115: Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA.
has exact synonym: telomerase RNA
has exact synonym: telomerase, template
type: Class
subclass of: part-of-parent-3720
subclass of: DNA template activity

telomerase catalytic core complex
IAO_0000115: The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.
has related synonym: TERT-TERC complex
type: Class
subclass of: GO_0005697
subclass of: GO_0042575

3-hydroxyanthranilate 3,4-dioxygenase activity
IAO_0000115: Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+).
has exact synonym: 3-hydroxyanthranilate oxygenase activity
has exact synonym: 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
has exact synonym: 3-hydroxyanthranilic acid dioxygenase activity
has exact synonym: 3-hydroxyanthranilic acid oxygenase activity
has exact synonym: 3-hydroxyanthranilic oxygenase activity
has related synonym: 3HAO
type: Class
subclass of: GO_0016702

negative regulation of transposition, DNA-mediated
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition.
has exact synonym: down regulation of DNA transposition
has exact synonym: down-regulation of DNA transposition
has exact synonym: downregulation of DNA transposition
has exact synonym: negative regulation of DNA transposition
has related synonym: inhibition of DNA transposition
type: Class
subclass of: regulation of transposition, DNA-mediated
subclass of: GO_0010529
subclass of: GO_0045910

positive regulation of transposition, DNA-mediated
IAO_0000115: Any process that activates or increases the frequency, rate or extent of DNA transposition.
has exact synonym: positive regulation of DNA transposition
has exact synonym: up regulation of DNA transposition
has exact synonym: up-regulation of DNA transposition
has exact synonym: upregulation of DNA transposition
has related synonym: activation of DNA transposition
has related synonym: stimulation of DNA transposition
type: Class
subclass of: regulation of transposition, DNA-mediated
subclass of: GO_0010530
subclass of: GO_0045911

regulation of transposition, DNA-mediated
IAO_0000115: Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule.
has exact synonym: regulation of DNA transposition
type: Class
subclass of: regulation of DNA recombination
subclass of: GO_0010528

protein deneddylation
IAO_0000115: The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
has related synonym: cullin deneddylation
replaces: GO_0010388
type: Class
subclass of: GO_0070646

RNA cap binding
IAO_0000115: Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
has related synonym: binding to mRNA cap
has related synonym: mRNA cap binding
has related synonym: snRNA cap binding
type: Class
subclass of: RNA binding

RNA 7-methylguanosine cap binding
IAO_0000115: Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
has exact synonym: RNA m7G cap binding
type: Class
subclass of: RNA cap binding

RNA trimethylguanosine cap binding
IAO_0000115: Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans.
has exact synonym: RNA m2,2,7G cap binding
type: Class
subclass of: RNA cap binding

RNA cap 4 binding
IAO_0000115: Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa.
type: Class
subclass of: RNA cap binding

plastid-encoded plastid RNA polymerase complex A
IAO_0000115: A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex.
has exact synonym: PEP-A
type: Class
subclass of: plastid-encoded plastid RNA polymerase complex

plastid-encoded plastid RNA polymerase complex B
IAO_0000115: A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation.
has exact synonym: PEP-B
type: Class
subclass of: plastid-encoded plastid RNA polymerase complex

cytosolic DNA-directed RNA polymerase complex
IAO_0000115: The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity.
type: Class
subclass of: part-of-parent-5829
subclass of: DNA-directed RNA polymerase complex

transcription export complex
IAO_0000115: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
has exact synonym: TREX complex
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0032991

THO complex
IAO_0000115: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0032991

mRNA branch site recognition
IAO_0000115: Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome.
has exact synonym: nuclear mRNA branch site recognition
has related synonym: U12-type nuclear mRNA branch site recognition
has related synonym: U2-type nuclear mRNA branch site recognition
has related synonym: spliceosomal A complex biosynthesis
has related synonym: spliceosomal A complex formation
has related synonym: spliceosomal B complex biosynthesis
has related synonym: spliceosomal B complex formation
replaces: GO_0000370
replaces: GO_0000371
type: Class
subclass of: part-of-parent-245
subclass of: GO_0022618

generation of catalytic spliceosome for first transesterification step
IAO_0000115: Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome.
has exact synonym: formation of catalytic spliceosome for first transesterification step
has related synonym: U12-type catalytic spliceosome formation for first transesterification step
has related synonym: U2-type catalytic spliceosome formation for first transesterification step
has related synonym: catalytic spliceosome assembly for first transesterification step
has related synonym: spliceosomal A2-2 complex biosynthesis
has related synonym: spliceosomal A2-2 complex formation
has related synonym: spliceosomal C1 complex biosynthesis
has related synonym: spliceosomal C1 complex formation
replaces: GO_0000356
replaces: GO_0000357
type: Class
subclass of: part-of-parent-393
subclass of: GO_0022618

generation of catalytic spliceosome for second transesterification step
IAO_0000115: Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.
has exact synonym: formation of catalytic spliceosome for second transesterification step
has related synonym: catalytic spliceosome assembly for second transesterification step
has related synonym: formation of catalytic U12-type spliceosome for second transesterification step
has related synonym: formation of catalytic U2-type spliceosome for second transesterification step
has related synonym: formation of spliceosomal A2-2 complex
has related synonym: formation of spliceosomal C1 complex
has related synonym: lariat formation, 5'-splice site cleavage
has related synonym: spliceosomal A2-3 complex biosynthesis
has related synonym: spliceosomal A2-3 complex formation
has related synonym: spliceosomal C2 complex biosynthesis
has related synonym: spliceosomal C2 complex formation
replaces: GO_0000358
replaces: GO_0000359
type: Class
subclass of: part-of-parent-393
subclass of: GO_0022618

trans assembly of SL-containing precatalytic spliceosome
IAO_0000115: Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA.
has exact synonym: trans assembly of spliced leader-containing precatalytic spliceosome
type: Class
subclass of: part-of-parent-245
subclass of: part-of-parent-45291
subclass of: GO_0022618

formation of quadruple SL/U4/U5/U6 snRNP
IAO_0000115: Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA.
type: Class
subclass of: part-of-parent-45291
subclass of: GO_0022618

cis assembly of pre-catalytic spliceosome
IAO_0000115: Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.
has related synonym: cis assembly of U12-type pre-catalytic spliceosome
has related synonym: cis assembly of U2-type pre-catalytic spliceosome
has related synonym: formation of spliceosomal A2-1 complex
has related synonym: formation of spliceosomal B1 complex
has related synonym: spliceosomal A2-1 complex biosynthesis
has related synonym: spliceosomal A2-1 complex formation
has related synonym: spliceosomal B1 complex biosynthesis
has related synonym: spliceosomal B1 complex formation
replaces: GO_0000360
replaces: GO_0000361
type: Class
subclass of: part-of-parent-245
subclass of: part-of-parent-45292
subclass of: GO_0022618

obsolete first U2-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins.
type: Class
subclass of: ObsoleteClass

obsolete first U12-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins.
type: Class
subclass of: ObsoleteClass

obsolete second U2-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.
type: Class
subclass of: ObsoleteClass

mRNA trans splicing, via spliceosome
IAO_0000115: The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
has exact synonym: nuclear mRNA trans splicing, via spliceosome
has related synonym: nuclear mRNA trans splicing, via U2-type spliceosome
type: Class
subclass of: mRNA splicing, via spliceosome

intergenic mRNA trans splicing
IAO_0000115: The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing.
has exact synonym: intergenic nuclear mRNA trans splicing
type: Class
subclass of: mRNA trans splicing, via spliceosome
subclass of: alternative mRNA splicing, via spliceosome

obsolete second U12-type spliceosomal transesterification activity
IAO_0000115: OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.
type: Class
subclass of: ObsoleteClass

Group I intron splicing
IAO_0000115: The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize).
has related synonym: mRNA splicing
type: Class
subclass of: RNA splicing, via transesterification reactions with guanosine as nucleophile

Group II intron splicing
IAO_0000115: The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat.
has related synonym: mRNA splicing
type: Class
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

Group III intron splicing
IAO_0000115: The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved.
has related synonym: mRNA splicing
type: Class
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

RNA splicing, via transesterification reactions
IAO_0000115: Splicing of RNA via a series of two transesterification reactions.
has related synonym: RNA splicing factor activity, transesterification mechanism
has related synonym: pre-mRNA splicing factor activity
has related synonym: spliceosomal catalysis
replaces: GO_0000385
replaces: GO_0031202
type: Class
subclass of: GO_0008380

RNA splicing, via transesterification reactions with guanosine as nucleophile
IAO_0000115: Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile.
type: Class
subclass of: RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
IAO_0000115: Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.
has related synonym: lariat RNA biosynthesis
has related synonym: lariat RNA formation
type: Class
subclass of: RNA splicing, via transesterification reactions

RNA exon ligation
IAO_0000115: The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.
type: Class
subclass of: part-of-parent-394
subclass of: GO_0016070

tRNA-type intron splice site recognition and cleavage
IAO_0000115: RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.
type: Class
subclass of: part-of-parent-6388
subclass of: GO_0006396

alternative mRNA splicing, via spliceosome
IAO_0000115: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
has exact synonym: alternative nuclear mRNA splicing, via spliceosome
has related synonym: splice site selection
type: Class
subclass of: mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome
IAO_0000115: Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
has exact synonym: regulation of alternative nuclear mRNA splicing, via spliceosome
has related synonym: splice site selection
type: Class
subclass of: GO_0048024

first spliceosomal transesterification activity
IAO_0000115: Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.
has related synonym: lariat formation, 5'-splice site cleavage
type: Class
subclass of: part-of-parent-375
subclass of: GO_0140098

second spliceosomal transesterification activity
IAO_0000115: Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
has related synonym: 3'-splice site cleavage, exon ligation
has related synonym: lariat formation, 5'-splice site cleavage
type: Class
subclass of: part-of-parent-375
subclass of: GO_0140098

spliceosomal snRNP assembly
IAO_0000115: The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
has related synonym: spliceosomal snRNP biogenesis
type: Class
subclass of: part-of-parent-398
subclass of: GO_0022618

spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
IAO_0000115: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).
has related synonym: 3'-splice site cleavage, exon ligation
has related synonym: U12-type spliceosome conformational change to release U4atac and U11
has related synonym: U2-type spliceosome conformational change to release U4 and U1
has related synonym: spliceosomal A1 complex biosynthesis
has related synonym: spliceosomal A1 complex formation
has related synonym: spliceosomal B2 complex biosynthesis
has related synonym: spliceosomal B2 complex formation
replaces: GO_0000396
replaces: GO_0000397
type: Class
subclass of: part-of-parent-393
subclass of: GO_0022618

mRNA 3'-splice site recognition
IAO_0000115: Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.
has exact synonym: nuclear mRNA 3'-splice site recognition
has related synonym: U12-type nuclear mRNA 3'-splice site recognition
has related synonym: U2-type nuclear mRNA 3'-splice site recognition
replaces: GO_0000382
replaces: GO_0000383
type: Class
subclass of: GO_0006376

spliceosomal complex disassembly
IAO_0000115: Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.
has exact synonym: spliceosome complex disassembly
has related synonym: U12-type spliceosome disassembly
has related synonym: U2-type spliceosome disassembly
has related synonym: spliceosome disassembly
replaces: GO_0000391
replaces: GO_0000392
type: Class
subclass of: part-of-parent-398
subclass of: GO_0032988

spliceosomal conformational changes to generate catalytic conformation
IAO_0000115: Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.
has related synonym: 3'-splice site cleavage, exon ligation
type: Class
subclass of: part-of-parent-398
subclass of: GO_0022618

RNA splicing, via endonucleolytic cleavage and ligation
IAO_0000115: Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
has related synonym: mRNA splicing
type: Class
subclass of: GO_0008380

mRNA 5'-splice site recognition
IAO_0000115: Recognition of the intron 5'-splice site by components of the assembling spliceosome.
has exact synonym: nuclear mRNA 5' splice site recognition
has exact synonym: nuclear mRNA 5'-splice site recognition
has related synonym: U12-type nuclear mRNA 5' splice site recognition
has related synonym: U12-type nuclear mRNA 5'-splice site recognition
has related synonym: U2-type nuclear mRNA 5' splice site recognition
has related synonym: U2-type nuclear mRNA 5'-splice site recognition
has related synonym: spliceosomal CC complex biosynthesis
has related synonym: spliceosomal CC complex formation
has related synonym: spliceosomal E complex biosynthesis
has related synonym: spliceosomal E complex formation
has related synonym: spliceosomal commitment complex biosynthesis
has related synonym: spliceosomal commitment complex formation
replaces: GO_0000368
replaces: GO_0000369
type: Class
subclass of: part-of-parent-45292
subclass of: GO_0006376

mRNA splicing, via spliceosome
IAO_0000115: The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
has exact synonym: nuclear mRNA splicing, via spliceosome
has related synonym: mRNA splicing
has related synonym: nuclear mRNA splicing via U12-type spliceosome
has related synonym: nuclear mRNA splicing via U2-type spliceosome
has related synonym: pre-mRNA splicing
has related synonym: splicing AT-AC intron
has related synonym: splicing GT-AG intron
replaces: GO_0006374
replaces: GO_0006375
type: Class
subclass of: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
subclass of: GO_0006397

cellular bud neck septin structure
IAO_0000115: Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle.
type: Class
subclass of: part-of-parent-32153
subclass of: part-of-parent-5935
subclass of: GO_0110165

four-way junction DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
has exact synonym: Holliday junction binding
has related synonym: forked DNA binding
type: Class
subclass of: DNA secondary structure binding

open form four-way junction DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.
has exact synonym: open form Holliday junction binding
type: Class
subclass of: four-way junction DNA binding

crossed form four-way junction DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands.
has exact synonym: crossed form Holliday junction binding
type: Class
subclass of: four-way junction DNA binding

Y-form DNA binding
IAO_0000115: Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.
has exact synonym: splayed Y-form DNA binding
has related synonym: forked DNA binding
type: Class
subclass of: DNA secondary structure binding

heteroduplex DNA loop binding
IAO_0000115: Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.
has related synonym: loop DNA binding
type: Class
subclass of: DNA secondary structure binding
subclass of: GO_0032135

bubble DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.
type: Class
subclass of: DNA secondary structure binding

double-strand/single-strand DNA junction binding
IAO_0000115: Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA.
type: Class
subclass of: DNA secondary structure binding

phagophore assembly site
IAO_0000115: Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
has exact synonym: PAS
has related synonym: perivacuolar space
has related synonym: pre-autophagosomal structure
type: Class
subclass of: part-of-parent-5737
subclass of: GO_0110165

EKC/KEOPS complex
IAO_0000115: A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
has exact synonym: KEOPS/EKC complex
has exact synonym: endopeptidase-like kinase chromatin-associated protein complex
has exact synonym: kinase, putative endopeptidase and other proteins of small size protein complex
type: Class
subclass of: part-of-parent-5622
subclass of: GO_0032991

regulation of transcription by galactose
IAO_0000115: Any process involving galactose that modulates the frequency, rate or extent or transcription.
type: Class
subclass of: GO_0006355

carbon catabolite repression of transcription by galactose
IAO_0000115: A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
has exact synonym: down regulation of transcription by galactose
has exact synonym: down-regulation of transcription by galactose
has exact synonym: downregulation of transcription by galactose
has related synonym: inhibition of transcription by galactose
type: Class
subclass of: regulation of transcription by galactose
subclass of: GO_0045013

positive regulation of transcription by galactose
IAO_0000115: Any process involving galactose that activates or increases the rate of transcription.
has exact synonym: up regulation of transcription by galactose
has exact synonym: up-regulation of transcription by galactose
has exact synonym: upregulation of transcription by galactose
has related synonym: activation of transcription by galactose
has related synonym: stimulation of transcription by galactose
type: Class
subclass of: regulation of transcription by galactose
subclass of: GO_0045991

histone peptidyl-prolyl isomerization
IAO_0000115: The modification of a histone by cis-trans isomerization of a proline residue.
has exact synonym: histone proline isomerization
type: Class
subclass of: protein peptidyl-prolyl isomerization
subclass of: GO_0016570

protein peptidyl-prolyl isomerization
IAO_0000115: The modification of a protein by cis-trans isomerization of a proline residue.
has exact synonym: protein proline isomerization
type: Class
subclass of: GO_0018208

regulation of histone H3-K36 methylation
IAO_0000115: Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
type: Class
subclass of: GO_0031060

negative regulation of histone H3-K36 methylation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has exact synonym: down regulation of histone H3-K36 methylation
has exact synonym: down-regulation of histone H3-K36 methylation
has exact synonym: downregulation of histone H3-K36 methylation
has related synonym: inhibition of histone H3-K36 methylation
type: Class
subclass of: regulation of histone H3-K36 methylation
subclass of: GO_0031061

positive regulation of histone H3-K36 methylation
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
has exact synonym: up regulation of histone H3-K36 methylation
has exact synonym: up-regulation of histone H3-K36 methylation
has exact synonym: upregulation of histone H3-K36 methylation
has related synonym: activation of histone H3-K36 methylation
has related synonym: stimulation of histone H3-K36 methylation
type: Class
subclass of: regulation of histone H3-K36 methylation
subclass of: GO_0031062

HIR complex
IAO_0000115: A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.
has exact synonym: HIRA complex
type: Class
subclass of: GO_0032991

RNA polymerase IV complex
IAO_0000115: RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex.
has exact synonym: DNA-directed RNA polymerase IV complex
has exact synonym: DNA-directed RNA polymerase IVa complex
replaces: GO_0000420
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0055029

RNA polymerase V complex
IAO_0000115: RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits.
has exact synonym: DNA-directed RNA polymerase IVb complex
has exact synonym: DNA-directed RNA polymerase V complex
replaces: GO_0080137
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0055029

autophagosome membrane
IAO_0000115: The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
has exact synonym: autophagic vacuole membrane
type: Class
subclass of: part-of-parent-5776
subclass of: GO_0005774

autophagy of mitochondrion
IAO_0000115: The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
has exact synonym: mitochondrion autophagy
has related synonym: mitophagy
type: Class
subclass of: GO_0006914
subclass of: GO_0061726

mitophagy
IAO_0000115: The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
has exact synonym: macromitophagy
type: Class
subclass of: autophagy of mitochondrion
subclass of: GO_0061912

micromitophagy
IAO_0000115: Degradation of a mitochondrion by lysosomal microautophagy.
type: Class
subclass of: autophagy of mitochondrion
subclass of: GO_0016237

pexophagy
IAO_0000115: The selective autophagy process in which a peroxisome is degraded by macroautophagy.
has exact synonym: macropexophagy
type: Class
subclass of: GO_0030242
subclass of: GO_0061912

micropexophagy
IAO_0000115: Degradation of a peroxisome by lysosomal microautophagy.
type: Class
subclass of: GO_0016237
subclass of: GO_0030242

plastid-encoded plastid RNA polymerase complex
IAO_0000115: An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition.
type: Class
subclass of: part-of-parent-9536
subclass of: DNA-directed RNA polymerase complex

DNA-directed RNA polymerase complex
IAO_0000115: A protein complex that possesses DNA-directed RNA polymerase activity.
type: Class
subclass of: GO_0030880

carbon catabolite regulation of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
has exact synonym: regulation of transcription from RNA polymerase II promoter by carbon catabolites
type: Class
subclass of: GO_0006357
subclass of: GO_0045990

regulation of transcription from RNA polymerase II promoter by glucose
IAO_0000115: Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
type: Class
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0046015

regulation of transcription from RNA polymerase II promoter by galactose
IAO_0000115: Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
type: Class
subclass of: regulation of transcription by galactose
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter

positive regulation of transcription from RNA polymerase II promoter by glucose
IAO_0000115: Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
has exact synonym: up regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: up-regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: upregulation of transcription from RNA polymerase II promoter by glucose
has related synonym: activation of transcription from RNA polymerase II promoter by glucose
has related synonym: stimulation of transcription from RNA polymerase II promoter by glucose
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter by glucose
subclass of: carbon catabolite activation of transcription from RNA polymerase II promoter
subclass of: GO_0046016

carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
IAO_0000115: A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
has exact synonym: down regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: down-regulation of transcription from RNA polymerase II promoter by glucose
has exact synonym: downregulation of transcription from RNA polymerase II promoter by glucose
has related synonym: inhibition of transcription from RNA polymerase II promoter by glucose
type: Class
subclass of: GO_0045014
subclass of: GO_0061987

carbon catabolite repression of transcription from RNA polymerase II promoter by galactose
IAO_0000115: Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
has exact synonym: down regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: down-regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: downregulation of transcription from RNA polymerase II promoter by galactose
has related synonym: inhibition of transcription from RNA polymerase II promoter by galactose
type: Class
subclass of: carbon catabolite repression of transcription by galactose
subclass of: regulation of transcription from RNA polymerase II promoter by galactose
subclass of: carbon catabolite repression of transcription from RNA polymerase II promoter

positive regulation of transcription from RNA polymerase II promoter by galactose
IAO_0000115: Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
has exact synonym: up regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: up-regulation of transcription from RNA polymerase II promoter by galactose
has exact synonym: upregulation of transcription from RNA polymerase II promoter by galactose
has related synonym: activation of transcription from RNA polymerase II promoter by galactose
has related synonym: stimulation of transcription from RNA polymerase II promoter by galactose
type: Class
subclass of: positive regulation of transcription by galactose
subclass of: regulation of transcription from RNA polymerase II promoter by galactose
subclass of: carbon catabolite activation of transcription from RNA polymerase II promoter

carbon catabolite activation of transcription from RNA polymerase II promoter
IAO_0000115: Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
has exact synonym: positive regulation of transcription from RNA polymerase II promoter by carbon catabolites
type: Class
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0045944
subclass of: GO_0045991

carbon catabolite repression of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.
has exact synonym: negative regulation of transcription from RNA polymerase II promoter by carbon catabolites
type: Class
subclass of: negative regulation of transcription by RNA polymerase II
subclass of: carbon catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0045013

core TFIIH complex portion of holo TFIIH complex
IAO_0000115: The core TFIIH complex when it is part of the general transcription factor TFIIH.
has exact synonym: SSL2-core TFIIH complex portion of holo TFIIH complex
replaces: GO_0000443
type: Class
subclass of: part-of-parent-5675
subclass of: transcription factor TFIIH core complex

transcription factor TFIIH core complex
IAO_0000115: The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.
has exact synonym: SSL2-core TFIIH complex
has exact synonym: core TFIIH complex
replaces: GO_0000441
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0090575

core TFIIH complex portion of NEF3 complex
IAO_0000115: The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3).
has exact synonym: SSL2-core TFIIH complex portion of NEF3 complex
replaces: GO_0000442
type: Class
subclass of: transcription factor TFIIH core complex
subclass of: part-of-parent-112

MIS12/MIND type complex
IAO_0000115: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.
has related synonym: Mis12 complex
type: Class
subclass of: part-of-parent-777
subclass of: GO_0032991

THO complex part of transcription export complex
IAO_0000115: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
has exact synonym: THO complex part of TREX complex
type: Class
subclass of: THO complex
subclass of: part-of-parent-346

nucleoplasmic THO complex
IAO_0000115: The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.
type: Class
subclass of: THO complex
subclass of: GO_0008023

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: endonucleolytic cleavage at A2
type: Class
subclass of: part-of-parent-462
subclass of: part-of-parent-466
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has exact synonym: cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
has related synonym: cleavage at C2
replaces: GO_0000490
type: Class
subclass of: part-of-parent-463
subclass of: part-of-parent-466
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species.
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

rRNA 2'-O-methylation
IAO_0000115: The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis.
type: Class
subclass of: GO_0031167

snoRNA guided rRNA 2'-O-methylation
IAO_0000115: The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation.
has related synonym: snoRNA guided rRNA 2'-O-ribose methylation
type: Class
subclass of: rRNA 2'-O-methylation

enzyme-directed rRNA 2'-O-methylation
IAO_0000115: The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA.
type: Class
subclass of: rRNA 2'-O-methylation

snoRNA guided rRNA pseudouridine synthesis
IAO_0000115: The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation.
type: Class
subclass of: GO_0031118

enzyme-directed rRNA pseudouridine synthesis
IAO_0000115: The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.
type: Class
subclass of: GO_0031118

obsolete dimethylation involved in SSU-rRNA maturation
IAO_0000115: OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes.
type: Class
subclass of: ObsoleteClass

endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
IAO_0000115: Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
subclass of: part-of-parent-2108
subclass of: part-of-parent-2109

endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
IAO_0000115: Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
subclass of: part-of-parent-2108

exonucleolytic trimming involved in rRNA processing
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule.
has related synonym: exonucleolytic trimming during rRNA processing
type: Class
subclass of: part-of-parent-6364
subclass of: cleavage involved in rRNA processing
subclass of: GO_0090503

maturation of 5.8S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.
type: Class
subclass of: GO_0006364

endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
has related synonym: endonucleolytic cleavage at site D
type: Class
subclass of: part-of-parent-462
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: GO_0031125

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
has related synonym: maturation of 18S rRNA
replaces: GO_1990041
type: Class
subclass of: GO_0030490

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of LSU-rRNA

endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.
has related synonym: endonucleolytic cleavage at A3
type: Class
subclass of: part-of-parent-463
subclass of: part-of-parent-466
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: exonucleolytic trimming involved in rRNA processing
subclass of: part-of-parent-466
subclass of: rRNA 5'-end processing

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of 5.8S rRNA

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: exonucleolytic trimming involved in rRNA processing
subclass of: part-of-parent-466
subclass of: GO_0031125

generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: processing at B2
type: Class
subclass of: part-of-parent-463
subclass of: GO_0031125

cleavage involved in rRNA processing
IAO_0000115: Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.
has related synonym: cleavage during rRNA processing
type: Class
subclass of: part-of-parent-6364
subclass of: GO_0090501

maturation of LSU-rRNA
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.
type: Class
subclass of: part-of-parent-42273
subclass of: GO_0006364

endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events.
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
has related synonym: endonucleolytic cleavage at A1
type: Class
subclass of: part-of-parent-462
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: rRNA 5'-end processing

maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of LSU-rRNA

maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: GO_0030490

maturation of 2S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule.
type: Class
subclass of: GO_0006364

maturation of 4.5S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule.
type: Class
subclass of: GO_0006364

generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
has related synonym: processing at C1
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: part-of-parent-463
subclass of: rRNA 5'-end processing

endonucleolytic cleavage involved in rRNA processing
IAO_0000115: Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA.
has related synonym: endonucleolytic cleavage during rRNA processing
type: Class
subclass of: cleavage involved in rRNA processing
subclass of: part-of-parent-6364
subclass of: GO_0090502

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
has related synonym: endonucleolytic cleavage at A-prime
has related synonym: endonucleolytic cleavage at A0
type: Class
subclass of: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
subclass of: part-of-parent-462

maturation of 5S rRNA
IAO_0000115: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.
type: Class
subclass of: GO_0006364

maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of 5S rRNA

endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species.
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: part-of-parent-474
subclass of: part-of-parent-487

cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: part-of-parent-473
subclass of: part-of-parent-475

cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
subclass of: part-of-parent-475
subclass of: part-of-parent-487

maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of 5.8S rRNA

maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of LSU-rRNA

maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: GO_0030490

small nucleolar ribonucleoprotein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: snoRNP assembly
type: Class
subclass of: GO_0022618

box C/D snoRNP assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: box C/D small nucleolar ribonucleoprotein complex assembly
type: Class
subclass of: small nucleolar ribonucleoprotein complex assembly

box H/ACA snoRNP assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex.
has exact synonym: box H/ACA small nucleolar ribonucleoprotein complex assembly
type: Class
subclass of: small nucleolar ribonucleoprotein complex assembly

box C/D snoRNA 3'-end processing
IAO_0000115: Any process involved in forming the mature 3' end of a box C/D snoRNA molecule.
has exact synonym: box C/D snoRNA 3' end processing
type: Class
subclass of: GO_0031126
subclass of: GO_0034963

box H/ACA snoRNA 3'-end processing
IAO_0000115: Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule.
has exact synonym: box H/ACA snoRNA 3' end processing
type: Class
subclass of: GO_0031126
subclass of: GO_0034964

DNA template activity
IAO_0000115: Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule.
has related synonym: base pairing with DNA
type: Class
subclass of: DNA binding
subclass of: GO_0140489

RNA polymerase I upstream activating factor complex
IAO_0000115: A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
has exact synonym: RNA polymerase I upstream activation factor complex
has exact synonym: UAF
type: Class
subclass of: RNA polymerase I transcription regulator complex

proteasome complex
IAO_0000115: A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
has exact synonym: proteasome
has related synonym: 26S proteasome
type: Class
subclass of: part-of-parent-5622
subclass of: GO_1905369

obsolete proteasome regulatory particle (sensu Bacteria)
IAO_0000115: OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
type: Class
subclass of: ObsoleteClass

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
IAO_0000115: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.
has exact synonym: GPI-GlcNAc transferase complex
has exact synonym: GPI-GnT complex
has exact synonym: GPI-N-acetylglucosaminyltransferase complex
type: Class
subclass of: part-of-parent-5789
subclass of: GO_0098796
subclass of: GO_1990234

embryonic axis specification
IAO_0000115: The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
has related synonym: embryonic axis determination
type: Class
subclass of: GO_0009798
subclass of: GO_0009880

mismatch base pair DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
type: Class
subclass of: GO_0019104

purine-specific mismatch base pair DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
has related synonym: A/G-specific adenine DNA glycosylase activity
type: Class
subclass of: mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
type: Class
subclass of: GO_0019104

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
has exact synonym: oxidized pyrimidine base lesion DNA N-glycosylase activity
has related synonym: DNA glycosylase/AP-lyase
has related synonym: DNA glycosylase/beta-lyase
has related synonym: bifunctional DNA glycosylase
has related synonym: endodeoxyribonuclease III
has related synonym: endonuclease III
has related synonym: endonuclease VIII activity
has related synonym: pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
replaces: GO_0019004
type: Class
subclass of: oxidized base lesion DNA N-glycosylase activity

pyrimidine dimer DNA N-glycosylase activity
IAO_0000115: Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
type: Class
subclass of: GO_0019104

achiasmate meiosis I
IAO_0000115: The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata.
has exact synonym: achiasmate meiosis I nuclear division
type: Class
subclass of: GO_0007127

meiotic DNA double-strand break processing
IAO_0000115: The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.
type: Class
subclass of: part-of-parent-51321
subclass of: DNA double-strand break processing
subclass of: GO_1903046

meiotic DNA recombinase assembly
IAO_0000115: During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.
type: Class
subclass of: DNA recombinase assembly
subclass of: GO_0061982

meiotic strand invasion
IAO_0000115: The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis.
has related synonym: meiotic D-loop biosynthesis
has related synonym: meiotic D-loop formation
has related synonym: meiotic displacement loop biosynthesis
has related synonym: meiotic displacement loop formation
type: Class
subclass of: part-of-parent-51321
subclass of: GO_0042148
subclass of: GO_0061982

meiotic joint molecule formation
IAO_0000115: The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.
type: Class
subclass of: part-of-parent-7131
subclass of: GO_1903046

meiotic mismatch repair
IAO_0000115: A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.
type: Class
subclass of: GO_0006298
subclass of: GO_0061982

meiotic DNA repair synthesis
IAO_0000115: During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template.
type: Class
subclass of: DNA synthesis involved in DNA repair
subclass of: GO_0061982

resolution of meiotic recombination intermediates
IAO_0000115: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.
has related synonym: resolution of meiotic joint molecules as recombinants
type: Class
subclass of: part-of-parent-51307
subclass of: part-of-parent-7131
subclass of: GO_0061982

meiotic heteroduplex formation
IAO_0000115: During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.
type: Class
subclass of: part-of-parent-6310
subclass of: GO_0061982

meiotic strand displacement
IAO_0000115: The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis.
has related synonym: meiotic D-loop dissociation
has related synonym: meiotic D-loop processing
has related synonym: meiotic displacement loop dissociation
has related synonym: meiotic displacement loop processing
type: Class
subclass of: strand displacement
subclass of: GO_0061982

nucleotide-excision repair, DNA damage recognition
IAO_0000115: The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.
has related synonym: pyrimidine-dimer repair, DNA damage recognition
type: Class
subclass of: part-of-parent-6289
subclass of: GO_0051276

transcription-coupled nucleotide-excision repair, DNA damage recognition
IAO_0000115: The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway.
has related synonym: pyrimidine-dimer repair, DNA damage recognition
type: Class
subclass of: nucleotide-excision repair, DNA damage recognition
subclass of: part-of-parent-6283

nucleotide-excision repair, DNA duplex unwinding
IAO_0000115: The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.
type: Class
subclass of: part-of-parent-6289
subclass of: GO_0032508

nucleotide-excision repair, DNA damage removal
IAO_0000115: The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage.
type: Class
subclass of: part-of-parent-6289
subclass of: GO_0044349

photoreactive repair
IAO_0000115: The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.
has related synonym: pyrimidine-dimer repair by photolyase
type: Class
subclass of: GO_0006290

pyrimidine dimer repair by nucleotide-excision repair
IAO_0000115: The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
type: Class
subclass of: GO_0006289
subclass of: GO_0006290

(R,R)-butanediol dehydrogenase activity
IAO_0000115: Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+).
has exact synonym: (R)-2,3-butanediol dehydrogenase activity
has exact synonym: (R)-diacetyl reductase activity
has exact synonym: 1-amino-2-propanol dehydrogenase activity
has exact synonym: 1-amino-2-propanol oxidoreductase activity
has exact synonym: 2,3-butanediol dehydrogenase activity
has exact synonym: D-(-)-butanediol dehydrogenase activity
has exact synonym: D-1-amino-2-propanol dehydrogenase activity
has exact synonym: D-1-amino-2-propanol:NAD(2) oxidoreductase activity
has exact synonym: D-aminopropanol dehydrogenase activity
has exact synonym: D-butanediol dehydrogenase activity
has exact synonym: aminopropanol oxidoreductase activity
has exact synonym: butylene glycol dehydrogenase activity
has exact synonym: butyleneglycol dehydrogenase activity
has related synonym: diacetyl (acetoin) reductase activity
type: Class
subclass of: GO_0016616

telomere maintenance via recombination
IAO_0000115: Any recombinational process that contributes to the maintenance of proper telomeric length.
has related synonym: telomerase-independent telomere maintenance
type: Class
subclass of: telomere maintenance
subclass of: GO_0006312

telomere maintenance
IAO_0000115: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
has related synonym: regulation of telomere length
type: Class
subclass of: GO_0006259
subclass of: GO_0032200
subclass of: GO_0060249

double-strand break repair via homologous recombination
IAO_0000115: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
has exact synonym: HDR
has exact synonym: HRR
has exact synonym: Rad51-dependent recombinational repair
has exact synonym: Rhp51-dependent recombinational repair
has exact synonym: homologous recombinational repair
has exact synonym: homology-directed repair
replaces: GO_0016924
type: Class
subclass of: recombinational repair
subclass of: GO_0006302

recombinational repair
IAO_0000115: A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.
type: Class
subclass of: GO_0006281
subclass of: GO_0006310

non-recombinational repair
IAO_0000115: A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA.
type: Class
subclass of: GO_0006281

double-strand break repair via break-induced replication
IAO_0000115: The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
type: Class
subclass of: double-strand break repair via homologous recombination

gene conversion at mating-type locus, DNA double-strand break formation
IAO_0000115: The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another.
type: Class
subclass of: part-of-parent-7534
subclass of: GO_0022414
subclass of: GO_0090305

DNA double-strand break processing
IAO_0000115: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.
type: Class
subclass of: part-of-parent-6302
subclass of: GO_0006259

DNA recombinase assembly
IAO_0000115: The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.
has exact synonym: Rad51 nucleoprotein filament formation
type: Class
subclass of: part-of-parent-45003
subclass of: GO_0065004
subclass of: GO_0090735

DNA synthesis involved in DNA repair
IAO_0000115: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
has related synonym: DNA repair synthesis
has related synonym: DNA synthesis during DNA repair
has related synonym: mitotic DNA repair synthesis
type: Class
subclass of: part-of-parent-6281
subclass of: GO_0071897

strand displacement
IAO_0000115: The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.
has related synonym: D-loop dissociation
has related synonym: D-loop processing
has related synonym: displacement loop dissociation
has related synonym: displacement loop processing
type: Class
subclass of: part-of-parent-6310
subclass of: GO_0006259

DNA strand renaturation
IAO_0000115: The identification and annealing of complementary base pairs in single-strand DNA.
type: Class
subclass of: GO_0006259
subclass of: GO_0032392

gene conversion at mating-type locus, DNA repair synthesis
IAO_0000115: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus.
type: Class
subclass of: DNA synthesis involved in DNA repair
subclass of: part-of-parent-7534
subclass of: GO_0022414

removal of nonhomologous ends
IAO_0000115: The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.
type: Class
subclass of: GO_0006259

double-strand break repair via single-strand annealing, removal of nonhomologous ends
IAO_0000115: During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.
type: Class
subclass of: removal of nonhomologous ends
subclass of: part-of-parent-45002

DNA catabolic process, endonucleolytic
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has exact synonym: DNA breakdown, endonucleolytic
has exact synonym: DNA degradation, endonucleolytic
has exact synonym: endonucleolytic DNA catabolism
has exact synonym: endonucleolytic degradation of DNA
type: Class
subclass of: GO_0006308
subclass of: GO_0090305

DNA catabolic process, exonucleolytic
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has exact synonym: DNA breakdown, exonucleolytic
has exact synonym: DNA degradation, exonucleolytic
has exact synonym: exonucleolytic degradation of DNA
type: Class
subclass of: GO_0006308
subclass of: GO_0090305

obsolete DNA strand annealing activity
IAO_0000115: OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA.
type: Class
subclass of: ObsoleteClass

nuclear membrane fusion
IAO_0000115: The joining of 2 or more lipid bilayer membranes that surround the nucleus.
type: Class
subclass of: GO_0090174

karyogamy
IAO_0000115: The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.
has exact synonym: nuclear fusion
has exact synonym: nuclear fusion during karyogamy
replaces: GO_0007335
type: Class
subclass of: part-of-parent-6997
subclass of: GO_0048284

karyogamy involved in conjugation with cellular fusion
IAO_0000115: During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.
has related synonym: karyogamy during conjugation with cellular fusion
type: Class
subclass of: karyogamy
subclass of: part-of-parent-747
subclass of: GO_0022414

nuclear migration involved in conjugation with cellular fusion
IAO_0000115: The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion.
has exact synonym: nuclear congression
has related synonym: nuclear migration during conjugation with cellular fusion
replaces: GO_0006946
type: Class
subclass of: part-of-parent-747
subclass of: GO_0022414
subclass of: GO_0030473

karyogamy involved in conjugation with mutual genetic exchange
IAO_0000115: During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena.
has exact synonym: karyogamy involved in conjugation without cellular fusion
type: Class
subclass of: karyogamy
subclass of: part-of-parent-748

nuclear migration involved in conjugation with mutual genetic exchange
IAO_0000115: The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion.
has exact synonym: nuclear migration involved in conjugation without cellular fusion
has related synonym: nuclear exchange during conjugation without cellular fusion
type: Class
subclass of: part-of-parent-744
subclass of: part-of-parent-748
subclass of: GO_0007097

conjugation
IAO_0000115: The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms.
type: Class
subclass of: GO_0044764

conjugation with cellular fusion
IAO_0000115: A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: cell fusion
has related synonym: mating
replaces: GO_0007322
replaces: GO_0007333
replaces: GO_0030461
replaces: GO_0030477
type: Class
subclass of: conjugation
subclass of: GO_0019953
subclass of: GO_0140253

conjugation with mutual genetic exchange
IAO_0000115: A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange.
has exact synonym: conjugation without cellular fusion
type: Class
subclass of: conjugation

response to pheromone triggering conjugation with cellular fusion
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: response to pheromone during conjugation with cellular fusion
replaces: GO_0007328
replaces: GO_0030434
type: Class
subclass of: GO_0031139
subclass of: GO_0071444

pheromone-dependent signal transduction involved in conjugation with cellular fusion
IAO_0000115: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: transduction of mating signal
replaces: GO_0007330
replaces: GO_0030454
type: Class
subclass of: part-of-parent-749
subclass of: GO_0032005

mitotic cell cycle G1 arrest in response to pheromone
IAO_0000115: The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: cell cycle arrest in response to pheromone
replaces: GO_0030571
type: Class
subclass of: part-of-parent-749
subclass of: GO_0071850

agglutination involved in conjugation with cellular fusion
IAO_0000115: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae.
has exact synonym: cell-cell adhesion during conjugation with cellular fusion
has exact synonym: cell-cell adhesion during mating
has related synonym: agglutination
replaces: GO_0007334
type: Class
subclass of: part-of-parent-747
subclass of: part-of-parent-749
subclass of: agglutination involved in conjugation
subclass of: GO_0022414

cell morphogenesis involved in conjugation with cellular fusion
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion.
has related synonym: shmoo orientation
has related synonym: shmooing
replaces: GO_0007332
type: Class
subclass of: part-of-parent-747
subclass of: cell morphogenesis involved in conjugation
subclass of: developmental process involved in reproduction

adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
IAO_0000115: In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
has exact synonym: adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion
has exact synonym: desensitization to pheromone during conjugation with cellular fusion
has related synonym: adaptation to pheromone during conjugation with cellular fusion
replaces: GO_0007331
replaces: GO_0030453
type: Class
subclass of: part-of-parent-749
subclass of: GO_0023058

cytogamy
IAO_0000115: During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: zygote formation
replaces: GO_0000218
replaces: GO_0030462
type: Class
subclass of: part-of-parent-747
subclass of: GO_0022413

response to pheromone regulating conjugation with mutual genetic exchange
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion.
has exact synonym: response to pheromone triggering conjugation without cellular fusion
type: Class
subclass of: GO_0007154
subclass of: GO_0046999
subclass of: GO_0071444

obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange
IAO_0000115: OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion.
type: Class
subclass of: ObsoleteClass

agglutination involved in conjugation with mutual genetic exchange
IAO_0000115: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism.
has exact synonym: agglutination involved in conjugation without cellular fusion
has exact synonym: sexual flocculation
type: Class
subclass of: part-of-parent-756
subclass of: agglutination involved in conjugation

cell morphogenesis involved in conjugation with mutual genetic exchange
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion.
has exact synonym: cellular morphogenesis involved in conjugation without cellular fusion
type: Class
subclass of: part-of-parent-748
subclass of: cell morphogenesis involved in conjugation

adaptation to pheromone regulating conjugation with mutual genetic exchange
IAO_0000115: In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses.
has exact synonym: desensitization to pheromone during conjugation without cellular fusion
has related synonym: adaptation to pheromone involved conjugation without cellular fusion
type: Class
subclass of: response to pheromone regulating conjugation with mutual genetic exchange
subclass of: GO_0022401

conjugant formation
IAO_0000115: During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing.
type: Class
subclass of: part-of-parent-748
subclass of: agglutination involved in conjugation

pheromone-induced unidirectional conjugation
IAO_0000115: The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types.
type: Class
subclass of: GO_0009291

obsolete cell morphogenesis involved in unidirectional conjugation
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation.
type: Class
subclass of: ObsoleteClass

obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation
IAO_0000115: OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation.
type: Class
subclass of: ObsoleteClass

response to pheromone regulating pheromone-induced unidirectional conjugation
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation.
has related synonym: response to pheromone during pheromone-induced unidirectional
type: Class
subclass of: GO_0019236
subclass of: GO_0046999

negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
IAO_0000115: In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses.
has exact synonym: desensitization to pheromone during pheromone-induced unidirectional conjugation
has exact synonym: negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
has related synonym: adaptation to pheromone during pheromone-induced unidirectional conjugation
type: Class
subclass of: part-of-parent-765
subclass of: GO_0022401

cell morphogenesis involved in conjugation
IAO_0000115: The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types.
type: Class
subclass of: part-of-parent-746
subclass of: cell morphogenesis

syncytium formation by plasma membrane fusion
IAO_0000115: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
has related synonym: cell fusion
type: Class
subclass of: GO_0006949
subclass of: GO_0140253

syncytium formation by mitosis without cytokinesis
IAO_0000115: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis.
has related synonym: syncytium formation by mitosis without cell division
type: Class
subclass of: GO_0006949

peptide pheromone export
IAO_0000115: The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones.
has related synonym: a-factor export
replaces: GO_0007325
type: Class
subclass of: GO_0009914
subclass of: GO_0015833

agglutination involved in conjugation
IAO_0000115: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation.
type: Class
subclass of: part-of-parent-746
subclass of: GO_0051703
subclass of: GO_0098610

mating pheromone activity
IAO_0000115: The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.
type: Class
subclass of: GO_0005186

phosphatidyl-N-methylethanolamine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
has exact synonym: PLMT
has exact synonym: S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity
has exact synonym: phosphatidyl-N-methylethanolamine methyltransferase activity
has exact synonym: phosphatidyl-N-monomethylethanolamine methyltransferase activity
has exact synonym: phosphatidylmonomethylethanolamine methyltransferase activity
has exact synonym: phospholipid methyltransferase activity
has related synonym: methyltransferase II
has related synonym: phosphatidylethanolamine methyltransferase I
type: Class
subclass of: GO_0008170
subclass of: GO_0008757

adenyl-nucleotide exchange factor activity
IAO_0000115: Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
type: Class
subclass of: GO_0030554
subclass of: GO_0060590

chromosome, centromeric region
IAO_0000115: The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: centromere complex
has exact synonym: chromosome, centric region
has related synonym: centromere
has related synonym: chromosome, pericentric region
replaces: GO_0097521
type: Class
subclass of: GO_0098687

kinetochore
IAO_0000115: A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
replaces: GO_0005699
type: Class
subclass of: part-of-parent-775
subclass of: GO_0043232
subclass of: GO_0099080

condensed chromosome kinetochore
IAO_0000115: A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
type: Class
subclass of: kinetochore
subclass of: part-of-parent-779
subclass of: part-of-parent-793

condensed nuclear chromosome kinetochore
IAO_0000115: A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules.
type: Class
subclass of: condensed chromosome kinetochore
subclass of: part-of-parent-780
subclass of: part-of-parent-794

condensed chromosome, centromeric region
IAO_0000115: The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: condensed chromosome, centric region
has related synonym: condensed chromosome, centromere
has related synonym: condensed chromosome, pericentric region
type: Class
subclass of: chromosome, centromeric region
subclass of: part-of-parent-793

condensed nuclear chromosome, centromeric region
IAO_0000115: The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
has exact synonym: condensed nuclear chromosome, centric region
has related synonym: condensed nuclear chromosome, centromere
has related synonym: condensed nuclear chromosome, pericentric region
type: Class
subclass of: condensed chromosome, centromeric region
subclass of: part-of-parent-5634
subclass of: part-of-parent-794

chromosome, telomeric region
IAO_0000115: The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
has related synonym: telomere
type: Class
subclass of: GO_0098687

telomere cap complex
IAO_0000115: A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.
type: Class
subclass of: part-of-parent-140445
subclass of: GO_0032993

nuclear telomere cap complex
IAO_0000115: A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
type: Class
subclass of: telomere cap complex
subclass of: part-of-parent-5634

nuclear chromosome, telomeric region
IAO_0000115: The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
has exact synonym: nuclear chromosome, telomere
type: Class
subclass of: chromosome, telomeric region
subclass of: part-of-parent-228
subclass of: part-of-parent-5634

chromatin
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
has related synonym: chromosome scaffold
replaces: GO_0005717
type: Class
subclass of: part-of-parent-5694
subclass of: GO_0110165

nucleosome
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
replaces: GO_0005718
type: Class
subclass of: part-of-parent-785
subclass of: GO_0032993
subclass of: GO_0044815

cytoplasmic nucleosome
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures.
type: Class
subclass of: nucleosome
subclass of: part-of-parent-5737
subclass of: part-of-parent-789

nuclear nucleosome
IAO_0000115: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
type: Class
subclass of: nucleosome
subclass of: part-of-parent-5634
subclass of: part-of-parent-790

cytoplasmic chromatin
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm.
type: Class
subclass of: chromatin
subclass of: part-of-parent-229
subclass of: part-of-parent-5737

nuclear chromatin
IAO_0000115: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
type: Class
subclass of: chromatin
subclass of: part-of-parent-228
subclass of: part-of-parent-5634

euchromatin
IAO_0000115: A dispersed and relatively uncompacted form of chromatin.
type: Class
subclass of: chromatin

heterochromatin
IAO_0000115: A compact and highly condensed form of chromatin.
type: Class
subclass of: chromatin

condensed chromosome
IAO_0000115: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
has related synonym: cytoplasmic mitotic chromosome
has related synonym: metaphase chromosome
has related synonym: mitotic chromosome
type: Class
subclass of: GO_0005694

condensed nuclear chromosome
IAO_0000115: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
has related synonym: meiotic chromosome
has related synonym: nuclear mitotic chromosome
type: Class
subclass of: nuclear chromosome
subclass of: condensed chromosome
subclass of: part-of-parent-5634

synaptonemal complex
IAO_0000115: A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.
replaces: GO_0005716
type: Class
subclass of: GO_0099086

condensin complex
IAO_0000115: A multisubunit protein complex that plays a central role in chromosome condensation.
has related synonym: 13S condensin complex
has related synonym: SMC complex
replaces: GO_0005676
replaces: GO_0008620
type: Class
subclass of: part-of-parent-793
subclass of: GO_0044815

condensin core heterodimer
IAO_0000115: The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation.
has related synonym: 8S condensin complex
has related synonym: Smc2-Smc4 complex
replaces: GO_0008621
type: Class
subclass of: part-of-parent-796
subclass of: GO_0032991

nuclear cohesin complex
IAO_0000115: A cohesin complex required for cohesion between sister chromatids that remain in the nucleus.
type: Class
subclass of: part-of-parent-5634
subclass of: part-of-parent-794
subclass of: GO_0008278

nuclear condensin complex
IAO_0000115: A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus.
type: Class
subclass of: condensin complex
subclass of: part-of-parent-794

lateral element
IAO_0000115: A proteinaceous core found between sister chromatids during meiotic prophase.
has exact synonym: axial element
type: Class
subclass of: part-of-parent-795
subclass of: GO_0110165

central element
IAO_0000115: A structural unit of the synaptonemal complex found between the lateral elements.
type: Class
subclass of: part-of-parent-795
subclass of: GO_0110165

transverse filament
IAO_0000115: A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.
type: Class
subclass of: part-of-parent-795
subclass of: GO_0110165

sex chromosome
IAO_0000115: A chromosome involved in sex determination.
type: Class
subclass of: GO_0005694

W chromosome
IAO_0000115: The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females.
type: Class
subclass of: sex chromosome

X chromosome
IAO_0000115: The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.
type: Class
subclass of: sex chromosome

Y chromosome
IAO_0000115: The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.
type: Class
subclass of: sex chromosome

Z chromosome
IAO_0000115: The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females.
type: Class
subclass of: sex chromosome

origin recognition complex
IAO_0000115: A multisubunit complex that is located at the replication origins of a chromosome.
has exact synonym: ORC
has exact synonym: origin of replication recognition complex
type: Class
subclass of: part-of-parent-5694
subclass of: GO_0032991

cytoplasmic origin of replication recognition complex
IAO_0000115: A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.
has exact synonym: cytoplasmic ORC
has related synonym: prokaryotic ORC
type: Class
subclass of: origin recognition complex
subclass of: part-of-parent-229
subclass of: part-of-parent-5737

diacylglycerol diphosphate phosphatase activity
IAO_0000115: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.
has exact synonym: DGPP phosphatase activity
has exact synonym: DGPP phosphohydrolase activity
has exact synonym: diacylglycerol pyrophosphate phosphatase activity
type: Class
subclass of: GO_0016462

GINS complex
IAO_0000115: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
has exact synonym: Go, Ichi, Ni and San complex
type: Class
subclass of: part-of-parent-228
subclass of: GO_0031261

Swr1 complex
IAO_0000115: A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
has exact synonym: SWR-C
type: Class
subclass of: histone deacetylase complex
subclass of: GO_0097346

ESCRT I complex
IAO_0000115: An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
has related synonym: endosomal sorting complex required for transport
type: Class
subclass of: part-of-parent-10008
subclass of: GO_0036452
subclass of: GO_0098796

ESCRT II complex
IAO_0000115: An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
has related synonym: endosomal sorting complex required for transport
type: Class
subclass of: part-of-parent-10008
subclass of: GO_0036452
subclass of: GO_0098796

ESCRT III complex
IAO_0000115: An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.
has related synonym: endosomal sorting complex required for transport
type: Class
subclass of: part-of-parent-10008
subclass of: GO_0036452
subclass of: GO_0098796

COMA complex
IAO_0000115: A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly.
has exact synonym: Ctf19p-Okp1p-Mcm1p-Ame1p complex
type: Class
subclass of: part-of-parent-778
subclass of: GO_0032991

nuclear MIS12/MIND complex
IAO_0000115: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
has exact synonym: MIND complex
has exact synonym: Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex
type: Class
subclass of: MIS12/MIND type complex
subclass of: part-of-parent-5634
subclass of: part-of-parent-778

sister chromatid segregation
IAO_0000115: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
type: Class
subclass of: GO_0051276
subclass of: GO_0098813

regulation of glutamine family amino acid metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
has exact synonym: regulation of glutamine family amino acid metabolism
type: Class
subclass of: GO_0006521

regulation of arginine metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
has exact synonym: regulation of arginine metabolism
type: Class
subclass of: regulation of glutamine family amino acid metabolic process

inositol hexakisphosphate binding
IAO_0000115: Interacting selectively and non-covalently with inositol hexakisphosphate.
has exact synonym: IP6 binding
has exact synonym: InsP6 binding
type: Class
subclass of: GO_0043168
subclass of: GO_0043178

inositol-1,4,5-trisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+).
has exact synonym: ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity
has related synonym: IpmK
has related synonym: inositol polyphosphate multikinase activity
has related synonym: inositol trisphosphate 6-kinase activity
type: Class
subclass of: GO_0051766

inositol tetrakisphosphate 3-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
has exact synonym: 1D-myo-inositol-tetrakisphosphate 3-kinase activity
has exact synonym: inositol 1,4,5,6-tetrakisphosphate 3-kinase activity
has related synonym: EC:2.7.1.151
has related synonym: IpmK
has related synonym: inositol polyphosphate multikinase activity
type: Class
subclass of: GO_0051765

inositol tetrakisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.
has exact synonym: 1D-myo-inositol-tetrakisphosphate 6-kinase activity
has exact synonym: inositol 1,3,4,5-tetrakisphosphate 6-kinase activity
type: Class
subclass of: GO_0051765

obsolete inositol pyrophosphate synthase activity
IAO_0000115: OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds.
type: Class
subclass of: ObsoleteClass

inositol-1,3,4,5,6-pentakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.
type: Class
subclass of: GO_0016301
subclass of: GO_0016776

inositol hexakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
type: Class
subclass of: GO_0016301
subclass of: GO_0016776

inositol heptakisphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.
type: Class
subclass of: GO_0016301
subclass of: GO_0016776

inositol hexakisphosphate 4-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate.
type: Class
subclass of: inositol hexakisphosphate kinase activity

inositol hexakisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.
type: Class
subclass of: inositol hexakisphosphate kinase activity

inositol hexakisphosphate 5-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
has exact synonym: ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity
type: Class
subclass of: inositol hexakisphosphate kinase activity

inositol heptakisphosphate 4-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate.
has exact synonym: IP7 4-kinase activity
has exact synonym: diphosphoinositol-pentakisphosphate 4-kinase activity
type: Class
subclass of: inositol heptakisphosphate kinase activity

inositol heptakisphosphate 6-kinase activity
IAO_0000115: Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
type: Class
subclass of: inositol heptakisphosphate kinase activity

ER ubiquitin ligase complex
IAO_0000115: A ubiquitin ligase complex found in the ER.
type: Class
subclass of: cytoplasmic ubiquitin ligase complex
subclass of: part-of-parent-5783
subclass of: part-of-parent-5789
subclass of: GO_0098796

Hrd1p ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).
has related synonym: HRD1 ubiquitin ligase complex
type: Class
subclass of: ER ubiquitin ligase complex

Doa10p ubiquitin ligase complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.
has exact synonym: Ssm4p ubiquitin ligase complex
type: Class
subclass of: ER ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-M complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
type: Class
subclass of: Hrd1p ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex
IAO_0000115: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
type: Class
subclass of: Hrd1p ubiquitin ligase complex

translation repressor activity, mRNA regulatory element binding
IAO_0000115: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
has related synonym: translation repressor activity, nucleic acid binding
type: Class
subclass of: GO_0030371
subclass of: GO_0090079

translation repressor activity, non-nucleic acid binding
IAO_0000115: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.
type: Class
subclass of: GO_0030371
subclass of: GO_0045183

cell morphogenesis
IAO_0000115: The developmental process in which the size or shape of a cell is generated and organized.
has exact synonym: cellular morphogenesis
replaces: GO_0007148
replaces: GO_0045790
replaces: GO_0045791
type: Class
subclass of: GO_0009653

obsolete regulation of cell shape during vegetative growth phase
IAO_0000115: OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods.
replaces: GO_0090061
type: Class
subclass of: ObsoleteClass

cell morphogenesis involved in differentiation
IAO_0000115: The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
type: Class
subclass of: cell morphogenesis
subclass of: part-of-parent-48468

sporocarp development involved in asexual reproduction
IAO_0000115: The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction.
has related synonym: conidium development
has related synonym: fruiting body formation involved in asexual reproduction
has related synonym: haploid fruiting
has related synonym: homokaryotic fruiting
has related synonym: imperfect stage fruiting body development
has related synonym: monokaryotic fruiting
type: Class
subclass of: part-of-parent-19954
subclass of: GO_0030584

6,7-dimethyl-8-ribityllumazine synthase activity
IAO_0000115: Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
has related synonym: lumazine synthase activity
type: Class
subclass of: GO_0016765

sulfonate dioxygenase activity
IAO_0000115: Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.
has exact synonym: sulfonate/alpha-ketoglutarate dioxygenase activity
has exact synonym: sulphonate dioxygenase activity
type: Class
subclass of: GO_0016706

taurine dioxygenase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite.
has exact synonym: 2-aminoethanesulfonate dioxygenase activity
has exact synonym: alpha-ketoglutarate-dependent taurine dioxygenase activity
has exact synonym: taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)
type: Class
subclass of: GO_0016706

sporocarp development involved in sexual reproduction
IAO_0000115: The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi.
has related synonym: ascus development
has related synonym: fruiting body development involved in sexual reproduction
has related synonym: fruiting body formation involved in sexual reproduction
has related synonym: perfect stage fruiting body development
type: Class
subclass of: part-of-parent-19953
subclass of: GO_0030584

cytokinesis
IAO_0000115: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has exact synonym: cell cycle cytokinesis
has exact synonym: cytokinesis involved in cell cycle
replaces: GO_0007104
replaces: GO_0016288
replaces: GO_0033205
type: Class
subclass of: part-of-parent-51301
subclass of: GO_0022402

cytokinesis by cell plate formation
IAO_0000115: The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana.
type: Class
subclass of: cytokinesis

assembly of actomyosin apparatus involved in cytokinesis
IAO_0000115: The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis.
has exact synonym: actomyosin apparatus assembly involved in cytokinesis
has exact synonym: cytokinesis, formation of actomyosin apparatus
has related synonym: formation of actomyosin apparatus involved in cytokinesis
type: Class
subclass of: part-of-parent-61640
subclass of: GO_0022607
subclass of: GO_0032506

preprophase band assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation.
has related synonym: preprophase band formation
type: Class
subclass of: part-of-parent-911
subclass of: GO_0022402
subclass of: GO_0022607

phragmoplast assembly
IAO_0000115: The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles).
has related synonym: phragmoplast formation
type: Class
subclass of: part-of-parent-911
subclass of: GO_1902407

actomyosin contractile ring assembly
IAO_0000115: The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
has exact synonym: contractile ring assembly
has exact synonym: cytokinesis, actomyosin contractile ring assembly
has related synonym: constriction ring assembly
has related synonym: cytokinesis, actomyosin contractile ring formation
has related synonym: cytokinesis, actomyosin ring biosynthesis
has related synonym: cytokinesis, actomyosin ring formation
has related synonym: cytokinesis, contractile ring assembly
replaces: GO_0045573
type: Class
subclass of: assembly of actomyosin apparatus involved in cytokinesis
subclass of: GO_0044837

actomyosin contractile ring contraction
IAO_0000115: The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle.
has exact synonym: contractile ring contraction involved in cell cycle cytokinesis
has exact synonym: cytokinesis, actomyosin ring contraction
has related synonym: contractile ring constriction
has related synonym: cytokinesis, contractile ring contraction
type: Class
subclass of: part-of-parent-44837
subclass of: GO_0036213

division septum assembly
IAO_0000115: The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
has exact synonym: division septum formation
has exact synonym: formation of division septum
has related synonym: division septum assembly involved in cell cycle cytokinesis
has related synonym: division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle
has related synonym: division septum formation involved in cell cycle cytokinesis
has related synonym: division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle
has related synonym: division septum formation involved in mitotic cell cycle
has related synonym: formation of division septum involved in mitotic cell cycle
has related synonym: mitotic division septum assembly
has related synonym: septation
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum biosynthesis involved in mitotic cell cycle
has related synonym: septin assembly and septum formation
has related synonym: septin assembly and septum formation involved in mitotic cell cycle
replaces: GO_0071937
replaces: GO_1902411
type: Class
subclass of: part-of-parent-910
subclass of: GO_0090529

division septum site selection
IAO_0000115: The process of marking the site where a division septum will form.
has exact synonym: selection of site for barrier cell septum biosynthesis
has exact synonym: selection of site for barrier cell septum formation
has exact synonym: selection of site for division septum formation
has exact synonym: septum positioning
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum formation
type: Class
subclass of: part-of-parent-917
subclass of: GO_0032506

cell plate assembly
IAO_0000115: The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast.
has related synonym: cell plate formation
type: Class
subclass of: part-of-parent-911
subclass of: GO_0022402
subclass of: GO_0022607

septum digestion after cytokinesis
IAO_0000115: The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.
has exact synonym: cell separation following cytokinesis
has related synonym: cell separation after cytokinesis
has related synonym: cytokinetic cell separation
has related synonym: daughter cell separation
has related synonym: mitotic cytokinetic cell separation
replaces: GO_1902409
replaces: GO_2000695
type: Class
subclass of: part-of-parent-51301
subclass of: GO_0009987

septin ring assembly
IAO_0000115: The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.
has related synonym: septin assembly and septum biosynthesis
has related synonym: septin assembly and septum formation
type: Class
subclass of: GO_0031106
subclass of: GO_0034622
subclass of: GO_0070925

spindle pole
IAO_0000115: Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
replaces: GO_0030615
type: Class
subclass of: part-of-parent-5819
subclass of: GO_0110165

equatorial microtubule organizing center
IAO_0000115: A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.
has exact synonym: EMTOC
has exact synonym: equatorial microtubule organising centre
type: Class
subclass of: part-of-parent-32153
subclass of: GO_0005815

gamma-tubulin ring complex, centrosomal
IAO_0000115: A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring.
has exact synonym: gamma-tubulin large complex, centrosomal
replaces: GO_0000925
replaces: GO_0000926
type: Class
subclass of: part-of-parent-242
subclass of: GO_0008274

gamma-tubulin small complex, centrosomal
IAO_0000115: A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus.
type: Class
subclass of: GO_0008275

gamma-tubulin small complex, spindle pole body
IAO_0000115: A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae.
has exact synonym: Tub4 complex
type: Class
subclass of: part-of-parent-5816
subclass of: GO_0008275

gamma-tubulin complex
IAO_0000115: A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.
type: Class
subclass of: part-of-parent-5815
subclass of: GO_0032991

gamma-tubulin large complex
IAO_0000115: A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.
replaces: GO_0000929
type: Class
subclass of: gamma-tubulin complex

P-body
IAO_0000115: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
has exact synonym: P body
has exact synonym: cytoplasmic mRNA processing body
has related synonym: cytoplasmic foci
type: Class
subclass of: GO_0036464

adventitious septum
IAO_0000115: A cell septum whose formation is independent of nuclear division.
type: Class
subclass of: GO_0030428

porous cell septum
IAO_0000115: A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments.
has related synonym: porous septum
type: Class
subclass of: GO_0030428

division septum
IAO_0000115: A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
has exact synonym: complete septum
has exact synonym: divison septum
has related synonym: cell septum surface
has related synonym: septum surface
replaces: GO_0043187
type: Class
subclass of: part-of-parent-32153
subclass of: GO_0030428

primary cell septum
IAO_0000115: A cell septum that forms following nuclear division.
has related synonym: primary septum
type: Class
subclass of: division septum

dolipore septum
IAO_0000115: A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome).
type: Class
subclass of: porous cell septum

GARP complex
IAO_0000115: A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.
has exact synonym: Golgi associated retrograde protein complex
has exact synonym: VFT tethering complex
has exact synonym: Vps fifty three tethering complex
type: Class
subclass of: part-of-parent-31410
subclass of: part-of-parent-5794
subclass of: GO_0099023

condensed chromosome inner kinetochore
IAO_0000115: The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
has exact synonym: inner kinetochore of condensed chromosome
has related synonym: inner centromere core complex
has related synonym: inner kinetochore plate
type: Class
subclass of: part-of-parent-777
subclass of: GO_0032991

condensed chromosome outer kinetochore
IAO_0000115: The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
has exact synonym: outer kinetochore of condensed chromosome
has related synonym: outer kinetochore plate
type: Class
subclass of: part-of-parent-777
subclass of: GO_0032991

condensed nuclear chromosome inner kinetochore
IAO_0000115: The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
has exact synonym: inner kinetochore of condensed nuclear chromosome
type: Class
subclass of: condensed chromosome inner kinetochore
subclass of: part-of-parent-778

condensed nuclear chromosome outer kinetochore
IAO_0000115: The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
has exact synonym: outer kinetochore of condensed nuclear chromosome
type: Class
subclass of: condensed chromosome outer kinetochore
subclass of: part-of-parent-778

retrotransposon nucleocapsid
IAO_0000115: A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog.
has exact synonym: VLP
has exact synonym: Virus-like particle
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0110165

amino acid catabolic process to alcohol via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
type: Class
subclass of: amino acid catabolic process via Ehrlich pathway
subclass of: GO_0046165

amino acid catabolic process to carboxylic acid via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
type: Class
subclass of: amino acid catabolic process via Ehrlich pathway
subclass of: GO_0046394

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009074

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
has exact synonym: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009083

methionine catabolic process to 3-methylthiopropanol
IAO_0000115: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
type: Class
subclass of: amino acid catabolic process to alcohol via Ehrlich pathway
subclass of: GO_0009087
subclass of: GO_0044272

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0009074

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
has exact synonym: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0009083

methionine catabolic process to 3-methylthiopropanoate
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.
type: Class
subclass of: amino acid catabolic process to carboxylic acid via Ehrlich pathway
subclass of: GO_0006633
subclass of: GO_0009087
subclass of: GO_0044272

amino acid catabolic process via Ehrlich pathway
IAO_0000115: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.
type: Class
subclass of: GO_0009063

nuclear-transcribed mRNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
has exact synonym: nuclear mRNA breakdown
has exact synonym: nuclear mRNA catabolism
has exact synonym: nuclear mRNA degradation
type: Class
subclass of: GO_0006402

mitochondrial RNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
type: Class
subclass of: mitochondrial RNA metabolic process
subclass of: GO_0006401

mitochondrial mRNA catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
type: Class
subclass of: mitochondrial RNA catabolic process
subclass of: GO_0006402

mitochondrial RNA metabolic process
IAO_0000115: The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
type: Class
subclass of: GO_0016070

regulation of mitochondrial RNA catabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
type: Class
subclass of: GO_0031329
subclass of: GO_0051252

negative regulation of mitochondrial RNA catabolic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
type: Class
subclass of: regulation of mitochondrial RNA catabolic process
subclass of: GO_1902369

positive regulation of mitochondrial RNA catabolic process
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
type: Class
subclass of: regulation of mitochondrial RNA catabolic process
subclass of: GO_0031331
subclass of: GO_0051254

mitochondrial RNA processing
IAO_0000115: The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.
type: Class
subclass of: mitochondrial RNA metabolic process
subclass of: GO_0006396
subclass of: GO_0140053

mitochondrial RNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
has related synonym: mitochondrial RNA 5' end processing
type: Class
subclass of: mitochondrial RNA processing
subclass of: RNA 5'-end processing

mitochondrial RNA 3'-end processing
IAO_0000115: Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
has related synonym: mitochondrial RNA 3' end processing
type: Class
subclass of: mitochondrial RNA processing
subclass of: GO_0031123

RNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an RNA molecule.
has exact synonym: RNA 5' end processing
type: Class
subclass of: GO_0006396

rRNA 5'-end processing
IAO_0000115: Any process involved in forming the mature 5' end of an rRNA molecule.
has exact synonym: rRNA 5' end processing
type: Class
subclass of: GO_0006364
subclass of: GO_0034471

tRNA exon ligation
IAO_0000115: An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed.
type: Class
subclass of: RNA exon ligation
subclass of: part-of-parent-6388

tRNA exon ligation utilizing ATP as source of linkage phosphate
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species.
type: Class
subclass of: tRNA exon ligation

tRNA exon ligation utilizing GTP as source of linkage phosphate
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process.
type: Class
subclass of: tRNA exon ligation

tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
IAO_0000115: A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans.
type: Class
subclass of: tRNA exon ligation

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
IAO_0000115: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.
type: Class
subclass of: GO_0051276

posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
IAO_0000115: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.
type: Class
subclass of: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Prp19 complex
IAO_0000115: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
has related synonym: NTC
has related synonym: Prp19/CDC5 complex
has related synonym: nineteen complex
type: Class
subclass of: GO_0032991

transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
has related synonym: regulatory region DNA binding
has related synonym: transcription regulatory region DNA binding
replaces: GO_0000975
replaces: GO_0044212
type: Class
subclass of: regulatory region nucleic acid binding
subclass of: GO_1990837

RNA polymerase II transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
has related synonym: RNA polymerase II regulatory region DNA binding
replaces: GO_0001012
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA binding
has related synonym: RNA polymerase II promoter proximal region sequence-specific DNA binding
has related synonym: RNA polymerase II proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding
replaces: GO_0000980
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding
subclass of: cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding
subclass of: core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific
IAO_0000115: Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
has exact synonym: RNA polymerase II transcription factor activity, sequence-specific DNA binding
has exact synonym: RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
has exact synonym: sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
has related synonym: RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding
has related synonym: RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding
has related synonym: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
has related synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
has related synonym: sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
has related synonym: transcription factor
has related synonym: transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
has related synonym: transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
has related synonym: transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
has related synonym: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
replaces: GO_0000982
replaces: GO_0001133
replaces: GO_0001200
replaces: GO_0001201
replaces: GO_0001202
replaces: GO_0001203
replaces: GO_0003705
type: Class
subclass of: part-of-parent-6357
subclass of: DNA-binding transcription factor activity

bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase.
has exact synonym: eubacterial-type RNA polymerase regulatory region DNA binding
has related synonym: bacterial-type RNA polymerase regulatory region DNA binding
has related synonym: eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding
replaces: GO_0001017
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

bacterial-type RNA polymerase core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a bacterial gene.
has exact synonym: eubacterial-type RNA polymerase core promoter sequence-specific DNA binding
type: Class
subclass of: bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
subclass of: core promoter sequence-specific DNA binding

bacterial-type cis-regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific upstream cis-regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the promoter of a bacterial gene (or cistron, or operon).
has exact synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
has exact synonym: eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase enhancer sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding
has related synonym: bacterial-type proximal promoter sequence-specific DNA binding
replaces: GO_0001150
type: Class
subclass of: bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
subclass of: cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.
has related synonym: cis-regulatory region binding
has related synonym: core promoter proximal region DNA binding
has related synonym: core promoter proximal region sequence-specific DNA binding
has related synonym: enhancer binding
has related synonym: enhancer sequence-specific DNA binding
has related synonym: promoter proximal region sequence-specific DNA binding
has related synonym: proximal promoter sequence-specific DNA binding
replaces: GO_0001158
replaces: GO_0001159
replaces: GO_0035326
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

obsolete transcription factor activity, protein binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, core RNA polymerase binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, core RNA polymerase II binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

RNA polymerase III cis-regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes.
type: Class
subclass of: cis-regulatory region sequence-specific DNA binding
subclass of: RNA polymerase III transcription regulatory region sequence-specific DNA binding

RNA polymerase II complex binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
has exact synonym: RNA polymerase II core binding
has exact synonym: RNAP II core binding
type: Class
subclass of: basal RNA polymerase II transcription machinery binding
subclass of: GO_0043175

RNA polymerase III core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
type: Class
subclass of: GO_0043175

RNA polymerase III general transcription initiation factor activity
IAO_0000115: An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC.
has exact synonym: RNA polymerase III general initiation factor activity
has related synonym: RNA polymerase III transcription factor activity, sequence-specific DNA binding
has related synonym: core RNA polymerase III binding transcription factor activity
has related synonym: sequence-specific DNA binding RNA polymerase III transcription factor activity
has related synonym: transcription factor activity, core RNA polymerase III binding
replaces: GO_0001034
type: Class
subclass of: part-of-parent-6383
subclass of: GO_0140223

bacterial-type RNA polymerase core enzyme binding
IAO_0000115: Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.
has exact synonym: eubacterial-type RNA polymerase core enzyme binding
type: Class
subclass of: GO_0043175

mitochondrial single-subunit type RNA polymerase binding
IAO_0000115: Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
type: Class
subclass of: single-subunit type RNA polymerase binding

RNA polymerase III type 1 promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
has related synonym: RNA polymerase III type 1 promoter DNA binding
replaces: GO_0001030
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding
subclass of: GO_0080084

RNA polymerase III type 2 promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
has related synonym: RNA polymerase III type 2 promoter DNA binding
replaces: GO_0001031
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding

obsolete RNA polymerase III transcription regulator recruiting activity
IAO_0000115: OBSOLETE. Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB.
replaces: GO_0001005
replaces: GO_0001008
replaces: GO_0001033
replaces: GO_0001038
replaces: GO_0001157
type: Class
subclass of: ObsoleteClass

RNA polymerase III type 3 promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
has related synonym: RNA polymerase III type 3 promoter DNA binding
replaces: GO_0001032
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding

obsolete transcription factor activity, RNA polymerase III transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
IAO_0000115: The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
has exact synonym: sequence-specific DNA binding transcription factor recruiting transcription factor activity
has exact synonym: transcription factor activity, sequence-specific DNA binding transcription factor recruiting
has related synonym: transcription factor activity, sequence-specific DNA-binding transcription factor recruiting
type: Class
subclass of: GO_0061629

obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC).
type: Class
subclass of: ObsoleteClass

snoRNA transcription by RNA polymerase III
IAO_0000115: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter.
has related synonym: snoRNA transcription from a type 2 RNA polymerase III promoter
type: Class
subclass of: GO_0006383
subclass of: GO_0009302

snoRNA transcription by RNA polymerase II
IAO_0000115: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
has exact synonym: snoRNA transcription from an RNA polymerase II promoter
type: Class
subclass of: GO_0006366
subclass of: GO_0009302

RNA polymerase III transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
has related synonym: RNA polymerase III regulatory region DNA binding
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

mitochondrial promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of the mitochondrial DNA.
has related synonym: HSP coding strand binding
has related synonym: HSP non-coding strand binding
has related synonym: HSPas binding
has related synonym: HSPs binding
has related synonym: LSP coding strand binding
has related synonym: LSP non-coding strand binding
has related synonym: LSPas binding
has related synonym: LSPs binding
has related synonym: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase core promoter sequence-specific DNA binding
has related synonym: mitochondrial RNA polymerase regulatory region DNA binding
has related synonym: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
has related synonym: mitochondrial heavy strand promoter anti-sense binding
has related synonym: mitochondrial heavy strand promoter sense binding
has related synonym: mitochondrial light strand promoter anti-sense binding
has related synonym: mitochondrial light strand promoter sense binding
has related synonym: mitochondrial proximal promoter sequence-specific DNA binding
replaces: GO_0000997
replaces: GO_0001044
replaces: GO_0001045
replaces: GO_0070361
replaces: GO_0070362
replaces: GO_0070363
replaces: GO_0070364
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

plastid promoter transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

RNA polymerase III general transcription initiation factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III.
has related synonym: RNA polymerase III transcription factor binding
type: Class
subclass of: GO_0140296

obsolete TFIIIB-type transcription factor activity
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
type: Class
subclass of: ObsoleteClass

RNA polymerase III hybrid type promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.
has related synonym: RNA polymerase III hybrid type promoter DNA binding
replaces: GO_0001037
type: Class
subclass of: RNA polymerase III cis-regulatory region sequence-specific DNA binding

obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.
type: Class
subclass of: ObsoleteClass

RNA polymerase I core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
type: Class
subclass of: GO_0043175

core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
has related synonym: core promoter binding
replaces: GO_0001047
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

RNA polymerase IV core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production.
type: Class
subclass of: GO_0043175

RNA polymerase V core binding
IAO_0000115: Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing.
type: Class
subclass of: GO_0043175

single-subunit type RNA polymerase binding
IAO_0000115: Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
has exact synonym: SP6-type RNA polymerase binding
has exact synonym: T3-type RNA polymerase binding
has exact synonym: T3/T7 type RNA polymerase binding
has exact synonym: T7-type RNA polymerase binding
type: Class
subclass of: GO_0070063

plastid single-subunit type RNA polymerase binding
IAO_0000115: Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
type: Class
subclass of: single-subunit type RNA polymerase binding

plastid PEP RNA polymerase core enzyme binding
IAO_0000115: Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.
type: Class
subclass of: bacterial-type RNA polymerase core enzyme binding

RNA polymerase I activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter
type: Class
subclass of: part-of-parent-6360
subclass of: DNA-directed 5'-3' RNA polymerase activity

RNA polymerase II activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter
type: Class
subclass of: part-of-parent-6366
subclass of: DNA-directed 5'-3' RNA polymerase activity

RNA polymerase III activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter
type: Class
subclass of: part-of-parent-6383
subclass of: DNA-directed 5'-3' RNA polymerase activity

RNA polymerase IV activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter
type: Class
subclass of: part-of-parent-1059
subclass of: DNA-directed 5'-3' RNA polymerase activity

RNA polymerase V activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter
type: Class
subclass of: part-of-parent-1060
subclass of: DNA-directed 5'-3' RNA polymerase activity

transcription by RNA polymerase IV
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter.
has exact synonym: transcription from RNA pol IV promoter
has exact synonym: transcription from RNA polymerase IV promoter
type: Class
subclass of: GO_0006351

transcription by RNA polymerase V
IAO_0000115: The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter.
has exact synonym: transcription from RNA pol V promoter
has exact synonym: transcription from RNA polymerase V promoter
type: Class
subclass of: GO_0006351

bacterial-type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
type: Class
subclass of: part-of-parent-1121
subclass of: DNA-directed 5'-3' RNA polymerase activity

plastid PEP-A RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
type: Class
subclass of: bacterial-type RNA polymerase activity
subclass of: part-of-parent-42793

plastid PEP-B RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
type: Class
subclass of: bacterial-type RNA polymerase activity
subclass of: part-of-parent-42793

single subunit type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: T3/T7 type RNA polymerase activity
type: Class
subclass of: DNA-directed 5'-3' RNA polymerase activity

mitochondrial single subunit type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
type: Class
subclass of: single subunit type RNA polymerase activity
subclass of: part-of-parent-6390

plastid single subunit type RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
type: Class
subclass of: single subunit type RNA polymerase activity
subclass of: part-of-parent-42793

regulatory region nucleic acid binding
IAO_0000115: Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
type: Class
subclass of: nucleic acid binding

transcription regulatory region RNA binding
IAO_0000115: Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon.
type: Class
subclass of: regulatory region RNA binding

regulatory region RNA binding
IAO_0000115: Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
type: Class
subclass of: regulatory region nucleic acid binding
subclass of: RNA binding

RNA-binding transcription regulator activity
IAO_0000115: Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences.
has exact synonym: RNA binding transcription regulator activity
has related synonym: RNA binding transcription factor activity
type: Class
subclass of: GO_0140110

transcription antitermination factor activity, RNA binding
IAO_0000115: Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein.
has exact synonym: RNA binding transcription antitermination factor activity
type: Class
subclass of: part-of-parent-31564
subclass of: GO_0140110

transcription antitermination factor activity, DNA binding
IAO_0000115: Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.
has exact synonym: DNA binding transcription antitermination factor activity
type: Class
subclass of: part-of-parent-31564
subclass of: GO_0140110

obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase II transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

nitrogen catabolite regulation of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
type: Class
subclass of: GO_0006357
subclass of: GO_0090293

nitrogen catabolite activation of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
type: Class
subclass of: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0090294

nitrogen catabolite repression of transcription from RNA polymerase II promoter
IAO_0000115: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
has exact synonym: negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
type: Class
subclass of: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
subclass of: GO_0090295

obsolete transcription factor activity, RNA polymerase I transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase II basal transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, TFIID-class binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

RNA polymerase II transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
type: Class
subclass of: GO_0008134

obsolete transcription factor activity, TFIIA-class binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, TFIIB-class binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, TFIIE-class binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, TFIIF-class transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, TFIIH-class binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

RNA polymerase II general transcription initiation factor binding
IAO_0000115: Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has exact synonym: RNA polymerase II basal transcription factor binding
type: Class
subclass of: basal RNA polymerase II transcription machinery binding
subclass of: GO_0140296

TFIIA-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
has exact synonym: TFIIA-class transcription factor binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877

TFIIB-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding

TFIID-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIID-class transcription factor binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877

TFIIE-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIIE-class transcription factor binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877

TFIIF-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIIF-class transcription factor binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877

TFIIH-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
has exact synonym: TFIIH-class transcription factor binding
type: Class
subclass of: RNA polymerase II general transcription initiation factor binding
subclass of: GO_0044877

basal transcription machinery binding
IAO_0000115: Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
type: Class
subclass of: GO_0005515

basal RNA polymerase II transcription machinery binding
IAO_0000115: Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
has exact synonym: basal RNAP II transcription machinery binding
type: Class
subclass of: basal transcription machinery binding

negative regulation of exit from mitosis
IAO_0000115: Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
has exact synonym: down regulation of exit from mitosis
has exact synonym: down-regulation of exit from mitosis
has exact synonym: downregulation of exit from mitosis
has related synonym: inhibition of exit from mitosis
type: Class
subclass of: GO_0007096
subclass of: GO_0045839
subclass of: GO_1901991

response to acid chemical
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
has related synonym: response to acid
has related synonym: response to acid anion
has related synonym: response to oxoanion
type: Class
subclass of: GO_0042221

RNA polymerase II activating transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
type: Class
subclass of: GO_0033613
subclass of: GO_0061629

RNA polymerase II repressing transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
type: Class
subclass of: GO_0061629
subclass of: GO_0070491

bacterial-type RNA polymerase holo enzyme binding
IAO_0000115: Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
has exact synonym: basal bacterial-type RNA polymerase transcription machinery binding
type: Class
subclass of: basal transcription machinery binding

promoter clearance during DNA-templated transcription
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has exact synonym: promoter clearance during DNA-dependent transcription
has related synonym: promoter escape
type: Class
subclass of: part-of-parent-6351
subclass of: GO_0032774

promoter clearance from RNA polymerase III promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase.
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-6383

promoter clearance from RNA polymerase II promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
has exact synonym: promoter escape from RNA polymerase II promoter
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-6366

DNA-templated transcription open complex formation
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: DNA-dependent transcriptional open complex formation
has exact synonym: DNA-templated transcriptional open complex formation
has related synonym: promoter melting
type: Class
subclass of: part-of-parent-6352
subclass of: protein-DNA complex remodeling

transcription open complex formation at RNA polymerase II promoter
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: RNA polymerase II promoter melting
has exact synonym: transcriptional open complex formation at RNA polymerase II promoter
type: Class
subclass of: DNA-templated transcription open complex formation
subclass of: part-of-parent-6367

protein-DNA-RNA complex
IAO_0000115: A macromolecular complex containing protein, DNA, and RNA molecules.
type: Class
subclass of: GO_0032991

protein-DNA-RNA complex subunit organization
IAO_0000115: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex.
has exact synonym: protein-DNA-RNA complex subunit organisation
type: Class
subclass of: GO_0043933

protein-DNA-RNA complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex.
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0034622

protein-DNA-RNA complex disassembly
IAO_0000115: The disaggregation of a protein-DNA-RNA complex into its constituent components.
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0032984

transcription ternary complex disassembly
IAO_0000115: The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components.
has exact synonym: transcription protein-DNA-RNA complex disassembly
type: Class
subclass of: protein-DNA-RNA complex disassembly
subclass of: part-of-parent-6353

protein-DNA-RNA complex remodeling
IAO_0000115: The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex.
type: Class
subclass of: protein-DNA-RNA complex subunit organization
subclass of: GO_0034367

protein-DNA complex remodeling
IAO_0000115: The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex.
type: Class
subclass of: GO_0034367
subclass of: GO_0071824

bacterial transcription
IAO_0000115: The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter.
has exact synonym: transcription from bacterial-type RNA polymerase promoter
type: Class
subclass of: GO_0006351

promoter clearance from bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor.
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-1121

transcription initiation from bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
type: Class
subclass of: part-of-parent-1121
subclass of: GO_0006352

transcription elongation from bacterial-type RNA polymerase promoter
IAO_0000115: The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase.
has exact synonym: RNA elongation from bacterial-type RNA polymerase promoter
type: Class
subclass of: part-of-parent-1121
subclass of: GO_0006354

transcription termination from bacterial-type RNA polymerase promoter
IAO_0000115: The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed.
type: Class
subclass of: part-of-parent-1121
subclass of: GO_0006353

bacterial-type RNA polymerase preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription.
has exact synonym: bacterial-type RNA polymerase transcription PIC biosynthesis
has exact synonym: bacterial-type RNA polymerase transcription PIC formation
has exact synonym: bacterial-type RNA polymerase transcriptional preinitiation complex formation
type: Class
subclass of: part-of-parent-1123
subclass of: GO_0070897

transcription open complex formation at bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the melting of the DNA hybrid of the core promoter region within a bacterial-type RNA polymerase promoter to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: transcriptional open complex formation at bacterial-type RNA polymerase promoter
type: Class
subclass of: DNA-templated transcription open complex formation
subclass of: part-of-parent-1123

obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase II transcription factor activity, TBP-class protein binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
type: Class
subclass of: ObsoleteClass

obsolete transcription regulator recruiting activity
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase II transcription regulator recruiting activity
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
replaces: GO_0001136
replaces: GO_0001137
replaces: GO_0001138
type: Class
subclass of: ObsoleteClass

RNA polymerase II complex recruiting activity
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
has exact synonym: core RNA polymerase II recruiting transcription factor activity
has related synonym: transcription factor activity, core RNA polymerase II recruiting
type: Class
subclass of: RNA polymerase II complex binding
subclass of: part-of-parent-51123

mitochondrial RNA polymerase termination site sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a DNA sequence that controls mitochondrial transcription termination.
has exact synonym: mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity
has exact synonym: transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding
replaces: GO_0001146
type: Class
subclass of: part-of-parent-6393
subclass of: transcription termination site sequence-specific DNA binding

transcription termination site sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
has related synonym: transcription termination site DNA binding
replaces: GO_0001160
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

bacterial-type RNA polymerase termination site sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase.
type: Class
subclass of: bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
subclass of: transcription termination site sequence-specific DNA binding

obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting
IAO_0000115: OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase III transcription factor recruiting
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III.
type: Class
subclass of: ObsoleteClass

TFIIIB-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
has exact synonym: TFIIIB-class transcription factor binding
type: Class
subclass of: RNA polymerase III general transcription initiation factor binding

TFIIIA-class transcription factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters.
type: Class
subclass of: RNA polymerase III general transcription initiation factor binding

TFIIIC-class transcription factor complex binding
IAO_0000115: Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
has exact synonym: TFIIIC-class transcription factor binding
type: Class
subclass of: RNA polymerase III general transcription initiation factor binding

intronic transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within.
has related synonym: intronic transcription regulatory region DNA binding
replaces: GO_0044213
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.
type: Class
subclass of: RNA polymerase II transcription regulatory region sequence-specific DNA binding
subclass of: intronic transcription regulatory region sequence-specific DNA binding

RNA polymerase I transcription regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I.
has related synonym: RNA polymerase I regulatory region DNA binding
replaces: GO_0001013
type: Class
subclass of: transcription regulatory region sequence-specific DNA binding

RNA polymerase I core promoter sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
has exact synonym: RNA polymerase I CORE element sequence-specific DNA binding
has exact synonym: RNA polymerase I core element sequence-specific DNA binding
has exact synonym: RNA polymerase I core promoter sequence-specific DNA binding
has related synonym: RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
has related synonym: transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting
replaces: GO_0001187
type: Class
subclass of: core promoter sequence-specific DNA binding
subclass of: RNA polymerase I transcription regulatory region sequence-specific DNA binding
subclass of: part-of-parent-1188

RNA polymerase I cis-regulatory region sequence-specific DNA binding
IAO_0000115: Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).
has related synonym: RNA polymerase I enhancer sequence-specific DNA binding
has related synonym: RNA polymerase I upstream control element sequence-specific DNA binding
has related synonym: RNA polymerase I upstream element sequence-specific DNA binding
replaces: GO_0001166
type: Class
subclass of: RNA polymerase I transcription regulatory region sequence-specific DNA binding

obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I.
type: Class
subclass of: ObsoleteClass

reverse transcription
IAO_0000115: A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis.
type: Class
subclass of: GO_0006278

transcription, RNA-templated
IAO_0000115: The cellular synthesis of RNA on a template of RNA.
has exact synonym: transcription, RNA-dependent
type: Class
subclass of: GO_0097659

DNA-templated transcriptional start site selection
IAO_0000115: Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has exact synonym: DNA-dependent transcriptional start site selection
type: Class
subclass of: part-of-parent-6352
subclass of: GO_0032774

transcriptional start site selection at RNA polymerase II promoter
IAO_0000115: Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
type: Class
subclass of: DNA-templated transcriptional start site selection
subclass of: part-of-parent-6367

transcriptional start site selection at RNA polymerase III promoter
IAO_0000115: Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
type: Class
subclass of: DNA-templated transcriptional start site selection
subclass of: part-of-parent-6384

transcriptional start site selection at bacterial-type RNA polymerase promoter
IAO_0000115: Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
type: Class
subclass of: DNA-templated transcriptional start site selection
subclass of: part-of-parent-1123

regulation of transcription open complex formation at RNA polymerase II promoter
IAO_0000115: Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
has exact synonym: regulation of transcriptional open complex formation at RNA polymerase II promoter
type: Class
subclass of: GO_0051128
subclass of: GO_0060260

regulation of transcriptional start site selection at RNA polymerase II promoter
IAO_0000115: Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
has exact synonym: regulation of transcription start site selection at RNA polymerase II promoter
has exact synonym: regulation of transcriptional start site selection at RNA polymerase II promoter
type: Class
subclass of: GO_0060260

RNA polymerase I general transcription initiation factor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I.
has related synonym: RNA polymerase I transcription factor binding
type: Class
subclass of: GO_0140296

RNA polymerase I general transcription initiation factor activity
IAO_0000115: An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3.
has exact synonym: RNA polymerase I transcription general initiation factor activity
has exact synonym: general RNA polymerase I transcription factor activity
has related synonym: core RNA polymerase I binding transcription factor activity
has related synonym: transcription factor activity, core RNA polymerase I binding
type: Class
subclass of: part-of-parent-6360
subclass of: GO_0140223

promoter clearance from RNA polymerase I promoter
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
type: Class
subclass of: promoter clearance during DNA-templated transcription
subclass of: part-of-parent-6360

transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript
IAO_0000115: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I.
type: Class
subclass of: part-of-parent-42790
subclass of: GO_0006362

promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript
IAO_0000115: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
type: Class
subclass of: promoter clearance from RNA polymerase I promoter
subclass of: part-of-parent-42790

obsolete RNA polymerase I transcription regulator recruiting activity
IAO_0000115: OBSOLETE. The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
type: Class
subclass of: ObsoleteClass

RNA polymerase I preinitiation complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.
has exact synonym: RNA polymerase I transcriptional preinitiation complex assembly
has related synonym: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
has related synonym: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript
replaces: GO_0001189
type: Class
subclass of: part-of-parent-6361
subclass of: GO_0070897

obsolete transcriptional activator activity, RNA polymerase II transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
type: Class
subclass of: ObsoleteClass

maintenance of transcriptional fidelity during DNA-templated transcription elongation
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation
type: Class
subclass of: part-of-parent-6354
subclass of: GO_0032774

maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
type: Class
subclass of: maintenance of transcriptional fidelity during DNA-templated transcription elongation
subclass of: part-of-parent-6368

maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter
type: Class
subclass of: maintenance of transcriptional fidelity during DNA-templated transcription elongation
subclass of: part-of-parent-1124

maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter
IAO_0000115: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter.
has exact synonym: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter
type: Class
subclass of: maintenance of transcriptional fidelity during DNA-templated transcription elongation
subclass of: part-of-parent-6385

regulation of mating-type specific transcription from RNA polymerase II promoter
IAO_0000115: Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
type: Class
subclass of: GO_0006357
subclass of: GO_0007532

positive regulation of mating-type specific transcription from RNA polymerase II promoter
IAO_0000115: Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter.
has exact synonym: up regulation of transcription from an RNA polymerase II promoter, mating-type specific
has exact synonym: up-regulation of transcription from an RNA polymerase II promoter, mating-type specific
has exact synonym: upregulation of transcription from an RNA polymerase II promoter, mating-type specific
has related synonym: activation of transcription from an RNA polymerase II promoter, mating-type specific
has related synonym: stimulation of transcription from an RNA polymerase II promoter, mating-type specific
type: Class
subclass of: regulation of mating-type specific transcription from RNA polymerase II promoter
subclass of: GO_0045895

negative regulation of mating-type specific transcription from RNA polymerase II promoter
IAO_0000115: Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
has exact synonym: down regulation of RNA polymerase II transcription, mating-type specific
has exact synonym: down-regulation of RNA polymerase II transcription, mating-type specific
has exact synonym: downregulation of RNA polymerase II transcription, mating-type specific
has related synonym: inhibition of RNA polymerase II transcription, mating-type specific
type: Class
subclass of: regulation of mating-type specific transcription from RNA polymerase II promoter
subclass of: GO_0045894

histone displacement
IAO_0000115: The removal of histones, including histone dimers, from nucleosomes within chromatin.
type: Class
subclass of: GO_0034728

histone H2A-H2B dimer displacement
IAO_0000115: The removal of a H2A-H2B histone dimer from a nucleosome within chromatin.
type: Class
subclass of: histone displacement

DNA-binding transcription activator activity
IAO_0000115: Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
has related synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
has related synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
has related synonym: transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has related synonym: transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
replaces: GO_0001140
replaces: GO_0001215
type: Class
subclass of: part-of-parent-45893
subclass of: DNA-binding transcription factor activity

DNA-binding transcription repressor activity
IAO_0000115: Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
has related synonym: bacterial-type DNA binding transcription repressor activity
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
has related synonym: cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
has related synonym: transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has related synonym: transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
replaces: GO_0001141
replaces: GO_0001218
replaces: GO_0001219
replaces: GO_0001220
type: Class
subclass of: part-of-parent-45892
subclass of: DNA-binding transcription factor activity

transcription cofactor binding
IAO_0000115: Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
type: Class
subclass of: GO_0008134

transcription corepressor binding
IAO_0000115: Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
type: Class
subclass of: transcription cofactor binding

transcription coactivator binding
IAO_0000115: Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
type: Class
subclass of: transcription cofactor binding

RNA polymerase II transcription cofactor binding
IAO_0000115: Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II.
type: Class
subclass of: transcription cofactor binding

RNA polymerase II transcription coactivator binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II.
type: Class
subclass of: transcription coactivator binding
subclass of: RNA polymerase II transcription cofactor binding

RNA polymerase II transcription corepressor binding
IAO_0000115: Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.
type: Class
subclass of: transcription corepressor binding
subclass of: RNA polymerase II transcription cofactor binding

DNA-binding transcription repressor activity, RNA polymerase II-specific
IAO_0000115: Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
has exact synonym: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has exact synonym: transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription
has related synonym: RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding
has related synonym: distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific
has related synonym: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
has related synonym: metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
has related synonym: proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
has related synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
has related synonym: transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
has related synonym: transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
has related synonym: transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
replaces: GO_0001078
replaces: GO_0001206
replaces: GO_0001210
replaces: GO_0001214
type: Class
subclass of: DNA-binding transcription factor activity, RNA polymerase II-specific
subclass of: DNA-binding transcription repressor activity
subclass of: part-of-parent-122

DNA-binding transcription activator activity, RNA polymerase II-specific
IAO_0000115: Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
has exact synonym: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has exact synonym: transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
has related synonym: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
has related synonym: RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding
has related synonym: RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding
has related synonym: RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding
has related synonym: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has related synonym: distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
has related synonym: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has related synonym: metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has related synonym: proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
has related synonym: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
has related synonym: transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
has related synonym: transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
has related synonym: transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
has related synonym: transcriptional activator activity, metal ion regulated sequence-specific DNA binding
has related synonym: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
replaces: GO_0001077
replaces: GO_0001205
replaces: GO_0001209
replaces: GO_0001211
replaces: GO_0001212
replaces: GO_0001213
type: Class
subclass of: DNA-binding transcription factor activity, RNA polymerase II-specific
subclass of: DNA-binding transcription activator activity
subclass of: part-of-parent-45944

chronological cell aging
IAO_0000115: The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
has exact synonym: chronological cell ageing
type: Class
subclass of: GO_0007569

progressive alteration of chromatin involved in cell aging
IAO_0000115: Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype.
has exact synonym: progressive alteration of chromatin during cell ageing
has related synonym: age-dependent accumulation of genetic damage
has related synonym: progressive alteration of chromatin during cell aging
type: Class
subclass of: part-of-parent-7569
subclass of: GO_0006325

replicative cell aging
IAO_0000115: The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
has exact synonym: replicative cell ageing
type: Class
subclass of: GO_0007569

nucleolar fragmentation involved in replicative aging
IAO_0000115: A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells.
has related synonym: nucleolar fragmentation during replicative ageing
has related synonym: nucleolar fragmentation during replicative aging
type: Class
subclass of: part-of-parent-1302
subclass of: GO_0007576

progressive alteration of chromatin involved in replicative cell aging
IAO_0000115: A process that results in changes in chromatin structure contributing to replicative cell aging.
has exact synonym: progressive alteration of chromatin during replicative cell ageing
has related synonym: progressive alteration of chromatin during replicative cell aging
type: Class
subclass of: progressive alteration of chromatin involved in cell aging
subclass of: part-of-parent-1302

progressive alteration of chromatin involved in chronological cell aging
IAO_0000115: A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells.
has related synonym: progressive alteration of chromatin during chronological cell ageing
has related synonym: progressive alteration of chromatin during chronological cell aging
type: Class
subclass of: progressive alteration of chromatin involved in cell aging
subclass of: part-of-parent-1300

age-dependent response to oxidative stress
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism.
type: Class
subclass of: part-of-parent-7571
subclass of: GO_0006979

extrachromosomal circular DNA accumulation involved in replicative cell aging
IAO_0000115: Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.
has related synonym: extrachromosomal circular DNA accumulation during replicative cell ageing
has related synonym: extrachromosomal circular DNA accumulation during replicative cell aging
type: Class
subclass of: progressive alteration of chromatin involved in replicative cell aging
subclass of: GO_0007580

negative regulation of chromatin silencing involved in replicative cell aging
IAO_0000115: The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins.
has exact synonym: loss of chromatin silencing involved in replicative cell aging
has related synonym: loss of chromatin silencing during replicative cell ageing
type: Class
subclass of: progressive alteration of chromatin involved in replicative cell aging
subclass of: part-of-parent-1302
subclass of: GO_0031936

obsolete age-dependent telomere shortening
IAO_0000115: OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process.
type: Class
subclass of: ObsoleteClass

extrachromosomal rDNA circle accumulation involved in replicative cell aging
IAO_0000115: Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.
has related synonym: extrachromosomal rDNA circle accumulation during replicative cell ageing
has related synonym: extrachromosomal rDNA circle accumulation during replicative cell aging
has related synonym: extrachromosomal ribosomal DNA circle accumulation during replicative cell aging
type: Class
subclass of: extrachromosomal circular DNA accumulation involved in replicative cell aging

formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
IAO_0000115: Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age.
has related synonym: assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
has related synonym: formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing
has related synonym: formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging
has related synonym: formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging
type: Class
subclass of: part-of-parent-1310
subclass of: formation of extrachromosomal circular DNA involved in replicative cell aging
subclass of: GO_0045458

replication of extrachromosomal rDNA circles involved in replicative cell aging
IAO_0000115: Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication.
has related synonym: replication of extrachromosomal rDNA circles during replicative cell ageing
has related synonym: replication of extrachromosomal rDNA circles during replicative cell aging
has related synonym: replication of extrachromosomal ribosomal DNA circles during replicative cell aging
type: Class
subclass of: part-of-parent-1310
subclass of: replication of extrachromosomal circular DNA involved in replicative cell aging

formation of extrachromosomal circular DNA involved in replicative cell aging
IAO_0000115: Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age.
has exact synonym: assembly of extrachromosomal circular DNA involved in replicative cell aging
has related synonym: formation of extrachromosomal circular DNA during replicative cell ageing
has related synonym: formation of extrachromosomal circular DNA during replicative cell aging
type: Class
subclass of: part-of-parent-1302
subclass of: part-of-parent-1307
subclass of: formation of extrachromosomal circular DNA

replication of extrachromosomal circular DNA involved in replicative cell aging
IAO_0000115: Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.
has exact synonym: replication of extrachromosomal circular DNA during replicative cell ageing
has related synonym: replication of extrachromosomal circular DNA during replicative cell aging
type: Class
subclass of: part-of-parent-1302
subclass of: part-of-parent-1307
subclass of: replication of extrachromosomal circular DNA

age-dependent response to reactive oxygen species
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
has exact synonym: age-dependent response to AOS
has exact synonym: age-dependent response to ROI
has exact synonym: age-dependent response to ROS
has exact synonym: age-dependent response to active oxygen species
has exact synonym: age-dependent response to reactive oxidative species
has exact synonym: age-dependent response to reactive oxygen intermediate
type: Class
subclass of: response to reactive oxygen species
subclass of: age-dependent response to oxidative stress

age-dependent response to reactive oxygen species involved in replicative cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
has exact synonym: age-dependent response to AOS during replicative cell aging
has exact synonym: age-dependent response to reactive oxidative species during replicative cell aging
has exact synonym: age-dependent response to reactive oxygen species during replicative cell ageing
has related synonym: age-dependent response to ROI during replicative cell aging
has related synonym: age-dependent response to ROS during replicative cell aging
has related synonym: age-dependent response to active oxygen species during replicative cell aging
has related synonym: age-dependent response to reactive oxygen intermediate during replicative cell aging
has related synonym: age-dependent response to reactive oxygen species during replicative cell aging
type: Class
subclass of: age-dependent response to oxidative stress involved in replicative cell aging
subclass of: GO_0072353

accumulation of oxidatively modified proteins involved in replicative cell aging
IAO_0000115: Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.
has related synonym: accumulation of oxidatively modified proteins during replicative cell ageing
has related synonym: accumulation of oxidatively modified proteins during replicative cell aging
type: Class
subclass of: age-dependent response to reactive oxygen species involved in replicative cell aging

formation of oxidatively modified proteins involved in replicative cell aging
IAO_0000115: Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.
has related synonym: formation of oxidatively modified proteins during replicative cell ageing
has related synonym: formation of oxidatively modified proteins during replicative cell aging
type: Class
subclass of: part-of-parent-1317
subclass of: GO_0006464

inheritance of oxidatively modified proteins involved in replicative cell aging
IAO_0000115: A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells.
has related synonym: inheritance of oxidatively modified proteins during replicative cell ageing
has related synonym: inheritance of oxidatively modified proteins during replicative cell aging
type: Class
subclass of: part-of-parent-1317
subclass of: GO_0008104

age-dependent response to reactive oxygen species involved in chronological cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
has related synonym: age-dependent response to AOS during chronological cell aging
has related synonym: age-dependent response to ROI during chronological cell aging
has related synonym: age-dependent response to ROS during chronological cell aging
has related synonym: age-dependent response to active oxygen species during chronological cell aging
has related synonym: age-dependent response to reactive oxidative species during chronological cell aging
has related synonym: age-dependent response to reactive oxygen intermediate during chronological cell aging
has related synonym: age-dependent response to reactive oxygen species during chronological cell ageing
has related synonym: age-dependent response to reactive oxygen species during chronological cell aging
type: Class
subclass of: part-of-parent-1300
subclass of: age-dependent response to oxidative stress involved in chronological cell aging
subclass of: GO_0072353

age-dependent general metabolic decline involved in replicative cell aging
IAO_0000115: A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.
has related synonym: age-dependent general metabolic decline during replicative cell ageing
has related synonym: age-dependent general metabolic decline involved in replicative cell aging
type: Class
subclass of: part-of-parent-1302
subclass of: GO_0007571

age-dependent response to oxidative stress involved in replicative cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.
has related synonym: age-dependent response to oxidative stress during replicative cell ageing
has related synonym: age-dependent response to oxidative stress during replicative cell aging
type: Class
subclass of: age-dependent response to oxidative stress
subclass of: part-of-parent-1321
subclass of: part-of-parent-34599

age-dependent general metabolic decline involved in chronological cell aging
IAO_0000115: A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.
has related synonym: age-dependent general metabolic decline during chronological cell ageing
has related synonym: age-dependent general metabolic decline during chronological cell aging
type: Class
subclass of: part-of-parent-1300
subclass of: GO_0007571

age-dependent response to oxidative stress involved in chronological cell aging
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.
has related synonym: age-dependent response to oxidative stress during chronological cell ageing
has related synonym: age-dependent response to oxidative stress during chronological cell aging
type: Class
subclass of: age-dependent response to oxidative stress
subclass of: part-of-parent-1300
subclass of: part-of-parent-1323
subclass of: GO_0034599

formation of extrachromosomal circular DNA
IAO_0000115: Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats.
has exact synonym: assembly of extrachromosomal circular DNA
type: Class
subclass of: GO_0006259
subclass of: GO_0022607

replication of extrachromosomal circular DNA
IAO_0000115: Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.
type: Class
subclass of: GO_0006260

mating projection base
IAO_0000115: The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone.
has related synonym: base of shmoo tip
has related synonym: conjugation tube base
type: Class
subclass of: part-of-parent-5937
subclass of: GO_0110165

SAM complex
IAO_0000115: A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.
has exact synonym: TOB complex
has exact synonym: mitochondrial sorting and assembly machinery complex
type: Class
subclass of: GO_0098799

signal transduction involved in filamentous growth
IAO_0000115: Relaying of environmental signals promoting filamentous growth.
has related synonym: MAPKKK cascade (pseudohyphal growth)
has related synonym: signal transduction during filamentous growth
type: Class
subclass of: part-of-parent-30447
subclass of: GO_0007165

invasive growth in response to glucose limitation
IAO_0000115: A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
has related synonym: colony morphology
type: Class
subclass of: GO_0036267

obsolete invasive growth
IAO_0000115: OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue.
type: Class
subclass of: ObsoleteClass

PAM complex, Tim23 associated import motor
IAO_0000115: Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.
has exact synonym: PAM complex
has exact synonym: mitochondrial import motor
has exact synonym: pre-sequence translocase-associated import motor
has exact synonym: presequence translocase-associated import motor
type: Class
subclass of: part-of-parent-5744
subclass of: part-of-parent-5759
subclass of: GO_0098800

glycerophosphodiester transmembrane transporter activity
IAO_0000115: Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.
type: Class
subclass of: part-of-parent-1407
subclass of: GO_0008514
subclass of: GO_0015605

glycerophosphodiester transmembrane transport
IAO_0000115: The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.
type: Class
subclass of: GO_0015711
subclass of: GO_0015748
subclass of: GO_0098656

guanine nucleotide transport
IAO_0000115: The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
type: Class
subclass of: GO_0015865

guanine nucleotide transmembrane transporter activity
IAO_0000115: Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other.
type: Class
subclass of: part-of-parent-1903790
subclass of: GO_0015216

chlamydospore formation
IAO_0000115: The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans.
has exact synonym: chlamydospore development
replaces: GO_0055027
type: Class
subclass of: GO_0043936
subclass of: GO_0048468

hyphal tip
IAO_0000115: The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
type: Class
subclass of: GO_0030427
subclass of: GO_0051286

skeletal system development
IAO_0000115: The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
has exact synonym: skeletal development
type: Class
subclass of: GO_0048731

cartilage condensation
IAO_0000115: The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
type: Class
subclass of: part-of-parent-48705
subclass of: part-of-parent-51216
subclass of: GO_0098743

ossification
IAO_0000115: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
has exact synonym: bone biosynthesis
has exact synonym: bone formation
has exact synonym: osteogenesis
type: Class
subclass of: GO_0032501

neurotransmitter uptake
IAO_0000115: The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
has exact synonym: neurotransmitter import
has related synonym: neurotransmitter import into glial cell
has related synonym: neurotransmitter import into neuron
has related synonym: neurotransmitter recycling
type: Class
subclass of: regulation of neurotransmitter levels
subclass of: GO_0006836
subclass of: GO_0098657

regulation of neurotransmitter levels
IAO_0000115: Any process that modulates levels of neurotransmitter.
type: Class
subclass of: GO_0065008

obsolete neurotransmitter biosynthetic process and storage
IAO_0000115: OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules.
type: Class
subclass of: ObsoleteClass

acetylcholine catabolic process in synaptic cleft
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.
has exact synonym: acetylcholine breakdown in synaptic cleft
has exact synonym: acetylcholine degradation in synaptic cleft
type: Class
subclass of: part-of-parent-7271
subclass of: GO_0006581

action potential
IAO_0000115: A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
type: Class
subclass of: GO_0042391

obsolete legumain activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.
type: Class
subclass of: ObsoleteClass

RNA methylation
IAO_0000115: Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
type: Class
subclass of: GO_0009451
subclass of: GO_0043414

obsolete fibrillin
IAO_0000115: OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome.
type: Class
subclass of: ObsoleteClass

dihydronicotinamide riboside quinone reductase activity
IAO_0000115: Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
has exact synonym: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity
has exact synonym: N-ribosyldihydronicotinamide dehydrogenase (quinone) activity
has exact synonym: NAD(P)H:quinone oxidoreductase 2 activity
has exact synonym: NQO(2) activity
has exact synonym: ribosyldihydronicotinamide dehydrogenase (quinone) activity
has related synonym: NAD(P)H:quinone oxidoreductase-2
has related synonym: NAD(P)H:quinone oxidoreductase2
has related synonym: NQO2
has related synonym: NRH:quinone oxidoreductase 2 activity
has related synonym: QR2 activity
has related synonym: quinone reductase 2 activity
type: Class
subclass of: GO_0016491

selenocysteine incorporation
IAO_0000115: The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.
type: Class
subclass of: GO_0006451

opioid peptide activity
IAO_0000115: Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.
type: Class
subclass of: GO_0048018

prostaglandin biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
has exact synonym: prostaglandin anabolism
has exact synonym: prostaglandin biosynthesis
has exact synonym: prostaglandin formation
has exact synonym: prostaglandin synthesis
type: Class
subclass of: GO_0006693
subclass of: GO_0046457

N-acetylglucosamine 6-O-sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.
has exact synonym: N-acetylglucosamine 6-O-sulphotransferase activity
type: Class
subclass of: GO_0008146

voltage-gated sodium channel complex
IAO_0000115: A sodium channel in a cell membrane whose opening is governed by the membrane potential.
has exact synonym: voltage gated sodium channel complex
has exact synonym: voltage-dependent sodium channel complex
has exact synonym: voltage-sensitive sodium channel complex
type: Class
subclass of: part-of-parent-5887
subclass of: GO_0034706
subclass of: GO_0098797

peptide amidation
IAO_0000115: The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions.
type: Class
subclass of: GO_0031179

outer dense fiber
IAO_0000115: A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.
has exact synonym: outer dense fibre
type: Class
subclass of: part-of-parent-36126
subclass of: GO_0099513

pseudouridine synthesis
IAO_0000115: The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.
has exact synonym: pseudouridylation
type: Class
subclass of: GO_0009451

retinoid metabolic process
IAO_0000115: The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
has exact synonym: retinoid metabolism
type: Class
subclass of: GO_0016101

obsolete globin
IAO_0000115: OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins.
type: Class
subclass of: ObsoleteClass

angiogenesis
IAO_0000115: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
has exact synonym: blood vessel formation from pre-existing blood vessels
type: Class
subclass of: part-of-parent-48514
subclass of: GO_0048646

obsolete proteoglycan sulfate transfer
IAO_0000115: OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate.
type: Class
subclass of: ObsoleteClass

microfibril
IAO_0000115: Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
has exact synonym: extended fibrils
has related synonym: fibrillin
type: Class
subclass of: part-of-parent-31012
subclass of: GO_0099512

obsolete elastin
IAO_0000115: OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues.
type: Class
subclass of: ObsoleteClass

obsolete elastin
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

lipopolysaccharide binding
IAO_0000115: Interacting selectively and non-covalently with lipopolysaccharide.
has exact synonym: LPS binding
has related synonym: endotoxin binding
type: Class
subclass of: GO_0008289
subclass of: GO_0097367

interleukin-21 receptor binding
IAO_0000115: Interacting selectively and non-covalently with the interleukin-21 receptor.
has related synonym: IL-21
has related synonym: interleukin-21 receptor ligand
type: Class
subclass of: GO_0005126

interleukin-21 receptor activity
IAO_0000115: Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: IL-21 receptor activity
has exact synonym: IL-21R
type: Class
subclass of: part-of-parent-38114
subclass of: GO_0004896

cornified envelope
IAO_0000115: A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).
type: Class
subclass of: GO_0005886

radial spoke
IAO_0000115: Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.
type: Class
subclass of: part-of-parent-5930
subclass of: GO_0032991

radial spoke head
IAO_0000115: Protein complex forming part of eukaryotic flagellar apparatus.
has exact synonym: radial spokehead
type: Class
subclass of: part-of-parent-1534
subclass of: GO_0032991

radial spoke stalk
IAO_0000115: Globular portion of the radial spoke that projects towards the central pair of microtubules.
type: Class
subclass of: part-of-parent-1534
subclass of: GO_0032991

N-acetylgalactosamine 4-O-sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.
has exact synonym: N-acetylgalactosamine 4-O-sulphotransferase activity
type: Class
subclass of: GO_0008146

cilium or flagellum-dependent cell motility
IAO_0000115: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
has exact synonym: ciliary/flagellar motility
has related synonym: ciliary or bacterial-type flagellar motility
type: Class
subclass of: GO_0048870

amyloid-beta binding
IAO_0000115: Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
has exact synonym: beta-amyloid binding
type: Class
subclass of: GO_0042277

ovarian follicle development
IAO_0000115: The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
has related synonym: follicular phase
type: Class
subclass of: part-of-parent-8585
subclass of: GO_0048608

ovulation from ovarian follicle
IAO_0000115: The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.
type: Class
subclass of: part-of-parent-8585
subclass of: GO_0022602
subclass of: GO_0030728

ovarian follicle rupture
IAO_0000115: Disruption of theca cell layer releasing follicular fluid and/or the oocyte.
type: Class
subclass of: part-of-parent-1542
subclass of: GO_0022602

initiation of primordial ovarian follicle growth
IAO_0000115: Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle).
type: Class
subclass of: part-of-parent-1541
subclass of: GO_0022602

primary ovarian follicle growth
IAO_0000115: Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).
type: Class
subclass of: part-of-parent-1541
subclass of: GO_0022602
subclass of: GO_0040007

preantral ovarian follicle growth
IAO_0000115: Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation.
type: Class
subclass of: part-of-parent-1541
subclass of: part-of-parent-48162
subclass of: GO_0022602
subclass of: GO_0040007

antral ovarian follicle growth
IAO_0000115: Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.
type: Class
subclass of: part-of-parent-1541
subclass of: developmental process involved in reproduction
subclass of: GO_0022602
subclass of: GO_0048589

follicular fluid formation in ovarian follicle antrum
IAO_0000115: The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis.
has exact synonym: ovarian follicle antrum/follicular fluid biosynthesis
has exact synonym: ovarian follicle antrum/follicular fluid formation
type: Class
subclass of: part-of-parent-1547
subclass of: GO_0022602

cumulus cell differentiation
IAO_0000115: The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.
has exact synonym: ovarian cumulus cell differentiation
type: Class
subclass of: part-of-parent-1547
subclass of: part-of-parent-48165
subclass of: developmental process involved in reproduction
subclass of: GO_0022412
subclass of: GO_0022602
subclass of: GO_0030855

ovarian cumulus expansion
IAO_0000115: Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.
has related synonym: ovarian cumulus growth
type: Class
subclass of: part-of-parent-1547
subclass of: part-of-parent-48165
subclass of: GO_0022602
subclass of: GO_0040007

ovarian follicle endowment
IAO_0000115: Association of oocytes with supporting epithelial granulosa cells to form primordial follicles.
type: Class
subclass of: part-of-parent-1541
subclass of: GO_0022602

ovarian follicle atresia
IAO_0000115: A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed.
type: Class
subclass of: part-of-parent-8585
subclass of: developmental process involved in reproduction

luteinization
IAO_0000115: The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
has related synonym: luteal phase
type: Class
subclass of: part-of-parent-8585
subclass of: GO_0022602

luteolysis
IAO_0000115: The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.
type: Class
subclass of: part-of-parent-8585
subclass of: GO_0022602

oocyte growth
IAO_0000115: The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
type: Class
subclass of: part-of-parent-48599
subclass of: developmental process involved in reproduction
subclass of: GO_0022412
subclass of: GO_0048588

oocyte maturation
IAO_0000115: A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
type: Class
subclass of: part-of-parent-48599
subclass of: developmental process involved in reproduction
subclass of: GO_0022412
subclass of: GO_0048469

obsolete metabolic process resulting in cell growth
IAO_0000115: OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell.
type: Class
subclass of: ObsoleteClass

regulation of cell growth
IAO_0000115: Any process that modulates the frequency, rate, extent or direction of cell growth.
type: Class
subclass of: GO_0040008
subclass of: GO_0051128

obsolete regulation of cell growth by detection of nuclear:cytoplasmic ratio
IAO_0000115: OBSOLETE. Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
type: Class
subclass of: ObsoleteClass

regulation of cell growth by extracellular stimulus
IAO_0000115: Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
has exact synonym: interpretation of external signals that regulate cell growth
has exact synonym: regulation of cell growth by detection of exogenous stimulus
has exact synonym: regulation of cell growth by sensing of exogenous stimulus
has exact synonym: regulation of growth by exogenous signal
has exact synonym: regulation of growth by exogenous stimuli
has exact synonym: regulation of growth by exogenous stimulus
has exact synonym: regulation of growth by external signal
has exact synonym: regulation of growth by external stimuli
has exact synonym: regulation of growth by external stimulus
type: Class
subclass of: regulation of cell growth
subclass of: part-of-parent-31668

fatty acid alpha-oxidation
IAO_0000115: A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
type: Class
subclass of: GO_0009062
subclass of: GO_0019395

response to protozoan
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
has exact synonym: response to protozoa
has exact synonym: response to protozoon
has related synonym: resistance to pathogenic protozoa
replaces: GO_0042833
type: Class
subclass of: GO_0051707

detection of protozoan
IAO_0000115: The series of events in which a stimulus from a protozoan is received and converted into a molecular signal.
has exact synonym: detection of protozoa
has exact synonym: detection of protozoon
has related synonym: perception of protozoa
type: Class
subclass of: response to protozoan
subclass of: GO_0098543

obsolete resistance to pathogenic protozoa
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

phorbol ester receptor activity
IAO_0000115: Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity.
type: Class
subclass of: GO_0038023

non-kinase phorbol ester receptor activity
IAO_0000115: Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.
type: Class
subclass of: phorbol ester receptor activity

cholesterol 25-hydroxylase activity
IAO_0000115: Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O.
has exact synonym: cholesterol 25-monooxygenase activity
has exact synonym: cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

blood vessel development
IAO_0000115: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
type: Class
subclass of: part-of-parent-1944
subclass of: GO_0048856

branching involved in blood vessel morphogenesis
IAO_0000115: The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
has related synonym: patterning of blood vessels
type: Class
subclass of: part-of-parent-1525
subclass of: part-of-parent-48514
subclass of: GO_0048754

vasculogenesis
IAO_0000115: The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
has exact synonym: vascular morphogenesis
type: Class
subclass of: part-of-parent-48514
subclass of: GO_0030154

non-tyrosine kinase fibroblast growth factor receptor activity
IAO_0000115: Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity.
has exact synonym: non-tyrosine kinase FGF receptor activity
has exact synonym: non-tyrosine kinase FGFR activity
type: Class
subclass of: GO_0004888

lactosylceramide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides.
has exact synonym: lactosylceramide anabolism
has exact synonym: lactosylceramide biosynthesis
has exact synonym: lactosylceramide formation
has exact synonym: lactosylceramide synthesis
type: Class
subclass of: GO_0006688
subclass of: GO_0046478
subclass of: GO_0046513

ganglioside metabolic process
IAO_0000115: The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
has exact synonym: ganglioside metabolism
type: Class
subclass of: GO_0006672
subclass of: GO_0006687

ganglioside biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
has exact synonym: ganglioside anabolism
has exact synonym: ganglioside biosynthesis
has exact synonym: ganglioside formation
has exact synonym: ganglioside synthesis
type: Class
subclass of: ganglioside metabolic process
subclass of: GO_0006688
subclass of: GO_0046513

globoside metabolic process
IAO_0000115: The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.
has exact synonym: globoside metabolism
type: Class
subclass of: GO_0006687

globoside biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).
has exact synonym: globoside anabolism
has exact synonym: globoside biosynthesis
has exact synonym: globoside formation
has exact synonym: globoside synthesis
type: Class
subclass of: globoside metabolic process
subclass of: GO_0006688

obsolete galectin
IAO_0000115: OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars.
type: Class
subclass of: ObsoleteClass

microtubule bundle formation
IAO_0000115: A process that results in a parallel arrangement of microtubules.
has exact synonym: microtubule bundling
type: Class
subclass of: microtubule cytoskeleton organization

medium-chain fatty acid transport
IAO_0000115: The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.
type: Class
subclass of: GO_0015908

detection of chemical stimulus involved in sensory perception of bitter taste
IAO_0000115: The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
has exact synonym: bitter taste detection
has exact synonym: perception of bitter taste, detection of chemical stimulus
has exact synonym: perception of bitter taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of bitter taste
has exact synonym: sensory detection of chemical stimulus during perception of bitter taste
has exact synonym: sensory transduction of bitter taste
has exact synonym: sensory transduction of chemical stimulus during perception of bitter taste
type: Class
subclass of: part-of-parent-50913
subclass of: GO_0050912

detection of chemical stimulus involved in sensory perception of sour taste
IAO_0000115: The series of events required for a sour taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of sour taste, detection of chemical stimulus
has exact synonym: perception of sour taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of chemical stimulus during perception of sour taste
has exact synonym: sensory detection of sour taste
has exact synonym: sensory transduction of chemical stimulus during perception of sour taste
has exact synonym: sensory transduction of sour taste
has exact synonym: sour taste detection
type: Class
subclass of: part-of-parent-50915
subclass of: GO_0050912

detection of chemical stimulus involved in sensory perception of sweet taste
IAO_0000115: The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of sweet taste, detection of chemical stimulus
has exact synonym: perception of sweet taste, sensory transduction of chemical stimulus
has exact synonym: sensory detection of chemical stimulus during perception of sweet taste
has exact synonym: sensory detection of sweet taste
has exact synonym: sensory transduction of chemical stimulus during perception of sweet taste
has exact synonym: sensory transduction of sweet taste
has exact synonym: sweet taste detection
type: Class
subclass of: part-of-parent-50916
subclass of: GO_0050912

detection of chemical stimulus involved in sensory perception of salty taste
IAO_0000115: The series of events required for a salty taste stimulus to be received and converted to a molecular signal.
has exact synonym: perception of salty taste, detection of chemical stimulus
has exact synonym: perception of salty taste, sensory transduction of chemical stimulus
has exact synonym: salty taste detection
has exact synonym: sensory detection of chemical stimulus during perception of salty taste
has exact synonym: sensory detection of salty taste
has exact synonym: sensory transduction of chemical stimulus during perception of salty taste
has exact synonym: sensory transduction of salty taste
type: Class
subclass of: part-of-parent-50914
subclass of: GO_0050912

obsolete rhodopsin-like receptor activity
IAO_0000115: OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor.
replaces: GO_0001620
type: Class
subclass of: ObsoleteClass

Gi/o-coupled serotonin receptor activity
IAO_0000115: Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
has exact synonym: 5-HT1 receptor activity
has exact synonym: serotonin receptor activity, coupled via Gi/o
type: Class
subclass of: GO_0004993

Gq/11-coupled serotonin receptor activity
IAO_0000115: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
has exact synonym: serotonin receptor activity, coupled via Gq/11
has related synonym: 5-HT2 receptor activity
type: Class
subclass of: GO_0004993

dopamine neurotransmitter receptor activity, coupled via Gs
IAO_0000115: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
has related synonym: dopamine D1 receptor activity
has related synonym: dopamine D5 receptor activity
replaces: GO_0001589
replaces: GO_0001590
type: Class
subclass of: GO_0004952

dopamine neurotransmitter receptor activity, coupled via Gi/Go
IAO_0000115: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
has related synonym: dopamine D2 receptor activity
has related synonym: dopamine D3 receptor activity
has related synonym: dopamine D4 receptor activity
replaces: GO_0001592
replaces: GO_0001593
replaces: GO_0001670
type: Class
subclass of: GO_0004952

trace-amine receptor activity
IAO_0000115: Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
type: Class
subclass of: GO_0008227

angiotensin receptor activity
IAO_0000115: Combining with angiotensin to initiate a change in cell activity.
type: Class
subclass of: part-of-parent-38166
subclass of: GO_0008528

angiotensin type I receptor activity
IAO_0000115: An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.
has exact synonym: PLC-activating angiotensin receptor activity
type: Class
subclass of: angiotensin receptor activity
subclass of: part-of-parent-86097

obsolete apelin-like receptor
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete chemokine receptor-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

peptide YY receptor activity
IAO_0000115: Combining with gut peptide YY to initiate a change in cell activity.
type: Class
subclass of: GO_0004983

pancreatic polypeptide receptor activity
IAO_0000115: Combining with pancreatic polypeptide PP to initiate a change in cell activity.
type: Class
subclass of: GO_0004983

obsolete vasopressin-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

urotensin II receptor activity
IAO_0000115: Combining with urotensin II to initiate a change in cell activity.
type: Class
subclass of: GO_0008528

adrenomedullin receptor activity
IAO_0000115: Combining with adrenomedullin to initiate a change in cell activity.
has related synonym: G10D receptor
type: Class
subclass of: GO_0097642

obsolete GPR37/endothelin B-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

neuromedin U receptor activity
IAO_0000115: Combining with neuromedin U to initiate a change in cell activity.
has exact synonym: NMUR activity
type: Class
subclass of: GO_0008188

G protein-coupled nucleotide receptor activity
IAO_0000115: Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein coupled nucleotide receptor activity
has exact synonym: G-protein coupled nucleotide receptor activity
has exact synonym: nucleotide receptor activity, G protein coupled
has exact synonym: nucleotide receptor activity, G-protein coupled
type: Class
subclass of: GO_0004930

G protein-coupled adenosine receptor activity
IAO_0000115: Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein coupled adenosine receptor activity
has exact synonym: G-protein coupled adenosine receptor activity
has exact synonym: P1 receptor
has exact synonym: adenosine receptor activity, G protein coupled
has exact synonym: adenosine receptor activity, G-protein coupled
has related synonym: A1 adenosine receptor activity, G protein coupled
has related synonym: A1 adenosine receptor activity, G-protein coupled
has related synonym: A2A adenosine receptor activity, G protein coupled
has related synonym: A2A adenosine receptor activity, G-protein coupled
has related synonym: A2B adenosine receptor activity, G protein coupled
has related synonym: A2B adenosine receptor activity, G-protein coupled
has related synonym: A3 adenosine receptor activity, G protein coupled
has related synonym: A3 adenosine receptor activity, G-protein coupled
has related synonym: G protein coupled A1 adenosine receptor activity
has related synonym: G protein coupled A2A adenosine receptor activity
has related synonym: G protein coupled A2B adenosine receptor activity
has related synonym: G protein coupled A3 adenosine receptor activity
has related synonym: G-protein-coupled A1 adenosine receptor activity
has related synonym: G-protein-coupled A2A adenosine receptor activity
has related synonym: G-protein-coupled A2B adenosine receptor activity
has related synonym: G-protein-coupled A3 adenosine receptor activity
has related synonym: adenosine nucleotide receptor
replaces: GO_0001610
replaces: GO_0001611
replaces: GO_0001612
replaces: GO_0001613
replaces: GO_0008501
type: Class
subclass of: part-of-parent-1973
subclass of: GO_0004930

purinergic nucleotide receptor activity
IAO_0000115: Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: purinoceptor
has exact synonym: purinoreceptor
has related synonym: P2 receptor
has related synonym: purinergic receptor activity
replaces: GO_0035586
type: Class
subclass of: part-of-parent-35590
subclass of: GO_0016502

obsolete thyrotropin releasing hormone and secretagogue-like receptors activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

growth hormone secretagogue receptor activity
IAO_0000115: Combining with ghrelin to initiate a change in cell activity.
has exact synonym: ghrelin receptor activity
type: Class
subclass of: GO_0004930

obsolete growth hormone secretagogue-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

virus receptor activity
IAO_0000115: Combining with a virus component and mediating entry of the virus into the cell.
has exact synonym: viral receptor activity
type: Class
subclass of: part-of-parent-46718
subclass of: GO_0140272

obsolete lysosphingolipid and lysophosphatidic acid receptor activity
IAO_0000115: OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity.
type: Class
subclass of: ObsoleteClass

G protein-coupled ADP receptor activity
IAO_0000115: Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has related synonym: ADP receptor activity
has related synonym: ADP-activated adenosine receptor activity
has related synonym: ADP-activated nucleotide receptor activity
has related synonym: K101 receptor
has related synonym: platelet ADP receptor activity
replaces: GO_0045032
type: Class
subclass of: GO_0045028

nociceptin receptor activity
IAO_0000115: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.
has exact synonym: OFQ receptor activity
has exact synonym: ORPH receptor
has exact synonym: nociceptin/orphanin-FQ receptor activity
has exact synonym: orphanin-FQ receptor activity
has related synonym: X-opioid receptor activity
type: Class
subclass of: GO_0004985

obsolete leucine-rich G-protein receptor-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete gastropyloric receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete G-protein receptor 45-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete GP40-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

cysteinyl leukotriene receptor activity
IAO_0000115: Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.
has exact synonym: CysLT receptor
type: Class
subclass of: GO_0004974

leukotriene B4 receptor activity
IAO_0000115: Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.
has related synonym: BLT receptor
type: Class
subclass of: GO_0004974

obsolete secretin-like receptor activity
IAO_0000115: OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor.
replaces: GO_0001638
type: Class
subclass of: ObsoleteClass

pituitary adenylate cyclase-activating polypeptide receptor activity
IAO_0000115: A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide.
has exact synonym: PACAP receptor
has exact synonym: pituitary adenylate cyclase activating polypeptide receptor
has exact synonym: pituitary adenylate cyclase activating protein receptor activity
has exact synonym: pituitary adenylyl cyclase activating protein receptor activity
has related synonym: pituitary adenylate cyclase-activating peptide receptor activity
has related synonym: pituitary adenylate cyclase-activating polypeptide receptor activity
replaces: GO_0016522
type: Class
subclass of: GO_0004930

calcitonin gene-related peptide receptor activity
IAO_0000115: Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.
has exact synonym: CGRP receptor
has exact synonym: calcitonin gene-related polypeptide receptor activity
type: Class
subclass of: GO_0097642

obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

G protein-coupled chemoattractant receptor activity
IAO_0000115: Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein chemoattractant receptor activity
has exact synonym: G-protein chemoattractant receptor activity
has exact synonym: G-protein coupled chemoattractant receptor activity
type: Class
subclass of: GO_0008528

PLC activating G protein-coupled glutamate receptor activity
IAO_0000115: A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.
has exact synonym: PLC activating G-protein coupled glutamate receptor activity
has exact synonym: PLC activating metabotropic glutamate receptor activity
has exact synonym: phospholipase C activating metabotropic glutamate receptor activity
has related synonym: Group I metabotropic glutamate receptor
has related synonym: group I metabotropic glutamate receptor activity
type: Class
subclass of: part-of-parent-7206
subclass of: GO_0098988

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
IAO_0000115: Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
has exact synonym: adenylyl cyclase inhibiting metabotropic glutamate receptor activity
has related synonym: adenylate cyclase inhibiting metabotropic glutamate receptor activity
type: Class
subclass of: part-of-parent-7196
subclass of: GO_0098988

group II metabotropic glutamate receptor activity
IAO_0000115: A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.
type: Class
subclass of: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

group III metabotropic glutamate receptor activity
IAO_0000115: A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.
type: Class
subclass of: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

cAMP receptor activity
IAO_0000115: Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: 3',5' cAMP receptor activity
has exact synonym: 3',5'-cAMP receptor activity
has exact synonym: adenosine 3',5'-cyclophosphate receptor activity
has exact synonym: cyclic AMP receptor activity
has related synonym: class E G protein coupled receptor
has related synonym: class E G-protein coupled receptor
has related synonym: class E GPCR
replaces: GO_0001644
type: Class
subclass of: GO_0045028

G protein-coupled cytokinin receptor activity
IAO_0000115: Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has exact synonym: G protein coupled cytokinin receptor activity
has exact synonym: G-protein coupled cytokinin receptor activity
has exact synonym: cytokinin receptor activity, G-protein coupled
type: Class
subclass of: GO_0004930
subclass of: GO_0009884

proteinase activated receptor activity
IAO_0000115: A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
type: Class
subclass of: GO_0008528

osteoblast differentiation
IAO_0000115: The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
has exact synonym: osteoblast cell differentiation
type: Class
subclass of: part-of-parent-1503
subclass of: GO_0030154

fibrillar center
IAO_0000115: A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
has exact synonym: fibrillar centre
type: Class
subclass of: part-of-parent-5730
subclass of: GO_0110165

dense fibrillar component
IAO_0000115: A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
has related synonym: pars fibrosa
type: Class
subclass of: part-of-parent-5730
subclass of: GO_0110165

granular component
IAO_0000115: A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
has related synonym: pars granulosa
type: Class
subclass of: part-of-parent-5730
subclass of: GO_0110165

peptide receptor activity
IAO_0000115: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
has related synonym: endogenous peptide receptor activity
has related synonym: exogenous peptide receptor activity
type: Class
subclass of: GO_0038023

eye development
IAO_0000115: The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
replaces: GO_0042460
type: Class
subclass of: part-of-parent-150063
subclass of: GO_0007423

urogenital system development
IAO_0000115: The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
type: Class
subclass of: GO_0048731

metanephros development
IAO_0000115: The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
type: Class
subclass of: kidney development

ureteric bud development
IAO_0000115: The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
type: Class
subclass of: GO_0072164

branching involved in ureteric bud morphogenesis
IAO_0000115: The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
has exact synonym: ureteric bud branching
type: Class
subclass of: part-of-parent-60675
subclass of: GO_0048754

temperature homeostasis
IAO_0000115: A homeostatic process in which an organism modulates its internal body temperature.
has exact synonym: thermoregulation
type: Class
subclass of: GO_0048871

fever generation
IAO_0000115: The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
has related synonym: pyrexia
type: Class
subclass of: GO_0006953
subclass of: GO_0031649

conditioned taste aversion
IAO_0000115: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
type: Class
subclass of: GO_0007631
subclass of: GO_0008306

behavioral fear response
IAO_0000115: An acute behavioral change resulting from a perceived external threat.
has exact synonym: behavioural fear response
type: Class
subclass of: behavioral defense response
subclass of: GO_0042596

G protein-coupled receptor binding
IAO_0000115: Interacting selectively and non-covalently with a G protein-coupled receptor.
has exact synonym: G protein coupled receptor binding
has exact synonym: G-protein coupled receptor binding
has related synonym: G protein coupled receptor ligand
has related synonym: G-protein-coupled receptor ligand
type: Class
subclass of: GO_0005102

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.
has exact synonym: CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity
has exact synonym: GalNAc alpha-2,6-sialyltransferase I activity
type: Class
subclass of: GO_0008373

response to hypoxia
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
has exact synonym: response to hypoxic stress
has exact synonym: response to lowered oxygen tension
has related synonym: response to intermittent hypoxia
has related synonym: response to sustained hypoxia
type: Class
subclass of: GO_0006950
subclass of: GO_0036293

ameboidal-type cell migration
IAO_0000115: Cell migration that is accomplished by extension and retraction of a pseudopodium.
has exact synonym: ameboid cell migration
has exact synonym: amoeboid cell migration
has exact synonym: amoeboidal cell migration
type: Class
subclass of: GO_0016477

acrosomal vesicle
IAO_0000115: A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
has exact synonym: acrosomal granule
has exact synonym: acrosome
type: Class
subclass of: GO_0030141

ATPase activator activity
IAO_0000115: Binds to and increases the ATP hydrolysis activity of an ATPase.
has exact synonym: ATPase stimulator activity
type: Class
subclass of: part-of-parent-32781
subclass of: GO_0008047
subclass of: GO_0060590

regulation of chromatin assembly or disassembly
IAO_0000115: Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.
has exact synonym: regulation of chromatin assembly/disassembly
type: Class
subclass of: GO_1902275

male germ cell nucleus
IAO_0000115: The nucleus of a male germ cell, a reproductive cell in males.
has exact synonym: male germ-cell nucleus
replaces: GO_0043081
type: Class
subclass of: GO_0043073

female germ cell nucleus
IAO_0000115: The nucleus of the female germ cell, a reproductive cell in females.
has exact synonym: female germ-cell nucleus
replaces: GO_0043080
type: Class
subclass of: GO_0043073

acrosome assembly
IAO_0000115: The formation of the acrosome from the spermatid Golgi.
has exact synonym: acrosome formation
type: Class
subclass of: part-of-parent-7286
subclass of: developmental process involved in reproduction
subclass of: GO_0010927
subclass of: GO_0022412
subclass of: GO_0033363
subclass of: GO_0070925

long-chain fatty acid metabolic process
IAO_0000115: The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has exact synonym: long-chain fatty acid metabolism
type: Class
subclass of: GO_0006631

formation of translation initiation ternary complex
IAO_0000115: Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
has exact synonym: translation initiation ternary complex assembly
type: Class
subclass of: part-of-parent-6413
subclass of: GO_0022618

cellular glucose homeostasis
IAO_0000115: A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
has exact synonym: cell glucose homeostasis
type: Class
subclass of: GO_0042593
subclass of: GO_0055082

tRNA 3'-terminal CCA addition
IAO_0000115: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.
has exact synonym: CCA-adding enzyme activity
has exact synonym: CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity
has exact synonym: ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity
has related synonym: -C-C-A pyrophosphorylase activity
has related synonym: ATP(CTP)-tRNA nucleotidyltransferase activity
has related synonym: ATP(CTP):tRNA nucleotidyltransferase activity
has related synonym: CCA tRNA nucleotidyltransferase activity
has related synonym: CTP(ATP):tRNA nucleotidyltransferase activity
has related synonym: CTP:tRNA cytidylyltransferase activity
has related synonym: ribonucleic cytidylyltransferase activity
has related synonym: tRNA CCA-diphosphorylase activity
has related synonym: tRNA adenylyl(cytidylyl)transferase activity
has related synonym: tRNA cytidylyltransferase activity
has related synonym: tRNA-nucleotidyltransferase activity
has related synonym: transfer RNA adenylyltransferase activity
has related synonym: transfer ribonucleate adenyltransferase activity
has related synonym: transfer ribonucleate adenylyltransferase activity
has related synonym: transfer ribonucleate cytidylyltransferase activity
has related synonym: transfer ribonucleate nucleotidyltransferase activity
has related synonym: transfer ribonucleic acid nucleotidyl transferase activity
has related synonym: transfer ribonucleic adenylyl (cytidylyl) transferase activity
has related synonym: transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity
has related synonym: transfer-RNA nucleotidyltransferase activity
type: Class
subclass of: GO_0042780

sialate O-acetylesterase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.
has exact synonym: N-acetylneuraminate acetyltransferase activity
has exact synonym: N-acyl-O-acetylneuraminate O-acetylhydrolase activity
has exact synonym: sialate 9(4)-O-acetylesterase activity
type: Class
subclass of: GO_0008126

tRNA 5'-leader removal
IAO_0000115: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
has exact synonym: tRNA 5' leader removal
type: Class
subclass of: GO_0099116

obsolete axonemal dynein heavy chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete axonemal dynein intermediate chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete axonemal dynein intermediate light chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete axonemal dynein light chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete cytoplasmic dynein heavy chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete cytoplasmic dynein intermediate chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete cytoplasmic dynein intermediate light chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete cytoplasmic dynein light chain
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

pseudophosphatase activity
IAO_0000115: Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.
type: Class
subclass of: GO_0019212

histamine metabolic process
IAO_0000115: The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine metabolism
type: Class
subclass of: GO_0006576
subclass of: GO_0052803
subclass of: GO_0097164

histamine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine anabolism
has exact synonym: histamine biosynthesis
has exact synonym: histamine formation
has exact synonym: histamine synthesis
replaces: GO_0001693
type: Class
subclass of: histamine metabolic process
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_0042401
subclass of: GO_1901362

histamine catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
has exact synonym: histamine breakdown
has exact synonym: histamine catabolism
has exact synonym: histamine degradation
type: Class
subclass of: histamine metabolic process
subclass of: GO_0042135
subclass of: GO_0042402
subclass of: GO_0052805

gastric acid secretion
IAO_0000115: The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
has related synonym: hydrochloric acid secretion
type: Class
subclass of: GO_0022600
subclass of: GO_0046717

histamine-induced gastric acid secretion
IAO_0000115: The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.
type: Class
subclass of: gastric acid secretion

gastrin-induced gastric acid secretion
IAO_0000115: The regulated release of gastric acid induced by the interaction of gastrin with its receptor.
type: Class
subclass of: gastric acid secretion

acetylcholine-induced gastric acid secretion
IAO_0000115: The regulated release of gastric acid by parietal cells in response to acetylcholine.
type: Class
subclass of: gastric acid secretion
subclass of: part-of-parent-1905145

embryonic development via the syncytial blastoderm
IAO_0000115: The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.
type: Class
subclass of: GO_0009792

in utero embryonic development
IAO_0000115: The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
type: Class
subclass of: GO_0043009

gastrulation with mouth forming second
IAO_0000115: A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
has exact synonym: deuterostomic gastrulation
replaces: GO_0010003
replaces: GO_0048276
type: Class
subclass of: GO_0007369

gastrulation with mouth forming first
IAO_0000115: A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.
has related synonym: protostomic gastrulation
type: Class
subclass of: GO_0007369

formation of primary germ layer
IAO_0000115: The formation of the ectoderm, mesoderm and endoderm during gastrulation.
type: Class
subclass of: part-of-parent-7369
subclass of: GO_0048646

ectoderm formation
IAO_0000115: The formation of ectoderm during gastrulation.
type: Class
subclass of: formation of primary germ layer
subclass of: part-of-parent-7398

endoderm formation
IAO_0000115: The formation of the endoderm during gastrulation.
has related synonym: endoblast formation
type: Class
subclass of: formation of primary germ layer
subclass of: part-of-parent-7492

mesoderm formation
IAO_0000115: The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
type: Class
subclass of: formation of primary germ layer
subclass of: part-of-parent-48332

cell fate specification
IAO_0000115: The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
type: Class
subclass of: part-of-parent-45165
subclass of: GO_0048869

cell fate determination
IAO_0000115: A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
type: Class
subclass of: part-of-parent-45165
subclass of: GO_0048869

mesodermal cell fate commitment
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the mesoderm.
has exact synonym: mesoderm cell fate commitment
type: Class
subclass of: part-of-parent-48333
subclass of: GO_0060795

endodermal cell fate commitment
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the endoderm.
has exact synonym: endoderm cell fate commitment
type: Class
subclass of: part-of-parent-35987
subclass of: GO_0060795

ectodermal cell fate commitment
IAO_0000115: The cell differentiation process that results in commitment of a cell to become part of the ectoderm.
has exact synonym: ectoderm cell fate commitment
type: Class
subclass of: part-of-parent-10668
subclass of: part-of-parent-1705
subclass of: GO_0060795

ectodermal cell fate determination
IAO_0000115: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
has exact synonym: ectoderm cell fate determination
type: Class
subclass of: cell fate determination
subclass of: part-of-parent-1712

endodermal cell fate specification
IAO_0000115: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
has exact synonym: endoderm cell fate specification
type: Class
subclass of: cell fate specification
subclass of: part-of-parent-1711

ectodermal cell fate specification
IAO_0000115: The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
has exact synonym: ectoderm cell fate specification
type: Class
subclass of: cell fate specification
subclass of: part-of-parent-1712

L-amino-acid oxidase activity
IAO_0000115: Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
has exact synonym: L-amino-acid:oxygen oxidoreductase (deaminating)
has exact synonym: ophio-amino-acid oxidase activity
type: Class
subclass of: GO_0016641

conversion of seryl-tRNAsec to selenocys-tRNAsec
IAO_0000115: The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine.
type: Class
subclass of: GO_0019988

conversion of lysyl-tRNA to pyrrolysyl-tRNA
IAO_0000115: The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate).
type: Class
subclass of: GO_0019988

obsolete intermediate filament associated protein
IAO_0000115: OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks.
type: Class
subclass of: ObsoleteClass

obsolete type I intermediate filament associated protein
IAO_0000115: OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates.
type: Class
subclass of: ObsoleteClass

obsolete type II intermediate filament associated protein
IAO_0000115: OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks.
type: Class
subclass of: ObsoleteClass

obsolete type III intermediate filament associated protein
IAO_0000115: OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane.
type: Class
subclass of: ObsoleteClass

stress fiber
IAO_0000115: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
has exact synonym: stress fibre
has related synonym: actin cable
type: Class
subclass of: GO_0042641
subclass of: GO_0097517

ruffle
IAO_0000115: Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
has related synonym: membrane ruffle
type: Class
subclass of: part-of-parent-31252
subclass of: GO_0120025

lipid kinase activity
IAO_0000115: Catalysis of the phosphorylation of a simple or complex lipid.
type: Class
subclass of: part-of-parent-46834
subclass of: GO_0016301

ceramide kinase activity
IAO_0000115: Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.
has exact synonym: ATP:ceramide 1-phosphotransferase activity
has exact synonym: acylsphingosine kinase activity
type: Class
subclass of: lipid kinase activity

2'-5'-oligoadenylate synthetase activity
IAO_0000115: Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
has exact synonym: (2-5')oligo(A) synthetase activity
has exact synonym: 2'-5' oligoadenylate synthetase activity
has exact synonym: 2-5A synthetase activity
has exact synonym: oligo-2',5'-adenylate synthetase activity
type: Class
subclass of: GO_0070566

formation of translation preinitiation complex
IAO_0000115: The joining of the small ribosomal subunit, ternary complex, and mRNA.
has exact synonym: formation of translation pre-initiation complex
has exact synonym: translation preinitiation complex assembly
type: Class
subclass of: part-of-parent-2183
subclass of: GO_0022618

formation of cytoplasmic translation initiation complex
IAO_0000115: Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
has exact synonym: cytoplasmic translation initiation complex assembly
has related synonym: formation of translation initiation complex
has related synonym: translation initiation complex assembly
type: Class
subclass of: part-of-parent-2183
subclass of: GO_0022618

galactosylceramide sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
has exact synonym: 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity
has exact synonym: 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity
has exact synonym: GSase
has exact synonym: cerebroside sulfotransferase activity
has exact synonym: galactocerebroside sulfotransferase activity
has exact synonym: galactolipid sulfotransferase activity
has exact synonym: galactosylceramide sulphotransferase activity
has exact synonym: glycolipid sulfotransferase activity
has exact synonym: glycosphingolipid sulfotransferase activity
type: Class
subclass of: GO_0050694

mRNA (N6-adenosine)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.
type: Class
subclass of: GO_0008174

prenylcysteine oxidase activity
IAO_0000115: Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.
has exact synonym: S-prenyl-L-cysteine:oxygen oxidoreductase activity
has exact synonym: prenylcysteine lyase activity
type: Class
subclass of: GO_0016670

establishment of planar polarity
IAO_0000115: Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
has related synonym: establishment of planar cell polarity
type: Class
subclass of: part-of-parent-1738
subclass of: GO_0007164

establishment of imaginal disc-derived wing hair orientation
IAO_0000115: Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
has exact synonym: establishment of wing hair orientation
type: Class
subclass of: establishment of planar polarity
subclass of: part-of-parent-35317
subclass of: GO_0009886

morphogenesis of a polarized epithelium
IAO_0000115: The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
has exact synonym: epithelial polarization
type: Class
subclass of: morphogenesis of an epithelium

sex chromatin
IAO_0000115: Chromatin that is part of a sex chromosome.
type: Class
subclass of: part-of-parent-803
subclass of: GO_0005720

Barr body
IAO_0000115: A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
type: Class
subclass of: nuclear chromosome
subclass of: X chromosome

XY body
IAO_0000115: A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
type: Class
subclass of: sex chromosome

oenocyte differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.
has exact synonym: oenocyte cell differentiation
type: Class
subclass of: GO_0030154

optic placode formation
IAO_0000115: The initial developmental process that will lead to the formation of an eye.
type: Class
subclass of: part-of-parent-48598
subclass of: GO_0060788

optic lobe placode formation
IAO_0000115: Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system.
has exact synonym: optic lobe and Bolwig's organ precursor formation
replaces: GO_0007457
type: Class
subclass of: GO_0060788

compound eye morphogenesis
IAO_0000115: The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
has exact synonym: insect-type retina morphogenesis
type: Class
subclass of: part-of-parent-48749
subclass of: GO_0048592

Bolwig's organ morphogenesis
IAO_0000115: The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.
type: Class
subclass of: part-of-parent-55034
subclass of: GO_0048592

optic lobe placode development
IAO_0000115: The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster.
has exact synonym: optic lobe and Bolwig's organ precursor development
has related synonym: optic placode development
replaces: GO_0048049
type: Class
subclass of: GO_0048856

photoreceptor outer segment
IAO_0000115: The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
type: Class
subclass of: part-of-parent-97733
subclass of: GO_0110165

compound eye photoreceptor cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
type: Class
subclass of: part-of-parent-1745
subclass of: eye photoreceptor cell differentiation

compound eye photoreceptor fate commitment
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.
replaces: GO_0007459
type: Class
subclass of: part-of-parent-1751
subclass of: GO_0042706

obsolete adult eye photoreceptor development (sensu Drosophila)
IAO_0000115: OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye.
type: Class
subclass of: ObsoleteClass

eye photoreceptor cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
type: Class
subclass of: part-of-parent-48592
subclass of: GO_0046530

neural crest cell migration
IAO_0000115: The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
type: Class
subclass of: ameboidal-type cell migration
subclass of: part-of-parent-14032

somitogenesis
IAO_0000115: The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
has exact synonym: formation of mesodermal clusters
type: Class
subclass of: part-of-parent-43009
subclass of: part-of-parent-61053
subclass of: GO_0009952
subclass of: GO_0035282
subclass of: GO_0048646

somite specification
IAO_0000115: The process in which individual somites establish identity during embryogenesis.
type: Class
subclass of: part-of-parent-1756
subclass of: GO_0007379
subclass of: GO_0009880

retinal dehydrogenase activity
IAO_0000115: Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
has exact synonym: cytosolic retinal dehydrogenase activity
has exact synonym: retinal:NAD+ oxidoreductase activity
type: Class
subclass of: GO_0016620

organ induction
IAO_0000115: The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.
has exact synonym: induction of an organ
type: Class
subclass of: regulation of animal organ formation
subclass of: GO_0031128
subclass of: GO_0110110

aminocarboxymuconate-semialdehyde decarboxylase activity
IAO_0000115: Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2).
has exact synonym: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)
has exact synonym: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity
has exact synonym: 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity
has exact synonym: ACMSD activity
has exact synonym: alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity
has exact synonym: alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity
has exact synonym: picolinic acid carboxylase activity
has exact synonym: picolinic acid decarboxylase activity
type: Class
subclass of: GO_0016831

beta-alanine transmembrane transporter activity
IAO_0000115: Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.
has related synonym: beta-alanine transporter activity
type: Class
subclass of: part-of-parent-1762
subclass of: GO_0015175

beta-alanine transport
IAO_0000115: The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
type: Class
subclass of: GO_0015804

morphogenesis of a branching structure
IAO_0000115: The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
has exact synonym: branching morphogenesis
type: Class
subclass of: GO_0009653
subclass of: GO_0032501

neuron migration
IAO_0000115: The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
has exact synonym: neuron chemotaxis
has exact synonym: neuronal migration
has related synonym: neuron guidance
type: Class
subclass of: part-of-parent-48699
subclass of: GO_0016477

membrane raft assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
has exact synonym: lipid raft assembly
has related synonym: lipid raft formation
has related synonym: membrane raft formation
type: Class
subclass of: GO_0031579
subclass of: GO_0071709

membrane raft polarization
IAO_0000115: The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes.
has exact synonym: lipid raft polarization
type: Class
subclass of: GO_0031580

establishment of lymphocyte polarity
IAO_0000115: The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.
has exact synonym: lymphocyte polarization
type: Class
subclass of: part-of-parent-46649
subclass of: GO_0030010

establishment of T cell polarity
IAO_0000115: The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.
has exact synonym: T cell polarization
has exact synonym: T lymphocyte polarization
has exact synonym: T-cell polarization
has exact synonym: establishment of T lymphocyte polarity
has exact synonym: establishment of T-cell polarity
has exact synonym: establishment of T-lymphocyte polarity
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: part-of-parent-42110

establishment of B cell polarity
IAO_0000115: The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.
has exact synonym: B cell polarization
has exact synonym: B lymphocyte polarization
has exact synonym: B-cell polarization
has exact synonym: establishment of B lymphocyte polarity
has exact synonym: establishment of B-cell polarity
has exact synonym: establishment of B-lymphocyte polarity
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: part-of-parent-42113

establishment of natural killer cell polarity
IAO_0000115: The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.
has exact synonym: NK cell polarization
has exact synonym: establishment of NK cell polarity
has exact synonym: natural killer cell polarization
type: Class
subclass of: establishment of lymphocyte polarity
subclass of: part-of-parent-30101

immunological synapse formation
IAO_0000115: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
has exact synonym: formation of immunological synapse
type: Class
subclass of: part-of-parent-46649
subclass of: GO_0009988

immunological synapse
IAO_0000115: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
has exact synonym: supramolecular activation cluster
has related synonym: c-SMAC
type: Class
subclass of: part-of-parent-5886
subclass of: GO_0110165

myeloid dendritic cell activation
IAO_0000115: The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
type: Class
subclass of: myeloid leukocyte activation

microglial cell activation
IAO_0000115: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
type: Class
subclass of: leukocyte activation involved in inflammatory response
subclass of: GO_0042116
subclass of: GO_0061900

cell activation
IAO_0000115: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
type: Class
subclass of: GO_0009987

leukocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has exact synonym: immune cell homeostasis
has exact synonym: leucocyte homeostasis
type: Class
subclass of: immune system process
subclass of: GO_0048872

T cell homeostatic proliferation
IAO_0000115: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
has exact synonym: T lymphocyte homeostatic proliferation
has exact synonym: T-cell homeostatic proliferation
has exact synonym: T-lymphocyte homeostatic proliferation
has exact synonym: resting T cell proliferation
has exact synonym: resting T-cell proliferation
type: Class
subclass of: part-of-parent-42592
subclass of: part-of-parent-43029
subclass of: GO_0042098

plasma membrane repair
IAO_0000115: The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
type: Class
subclass of: part-of-parent-42060
subclass of: GO_0007009

natural killer cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
has exact synonym: NK cell differentiation
has related synonym: natural killer cell development
type: Class
subclass of: GO_0030098
subclass of: GO_0030101

neutrophil homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
type: Class
subclass of: leukocyte homeostasis
subclass of: myeloid cell homeostasis

neutrophil apoptotic process
IAO_0000115: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
has exact synonym: apoptosis of neutrophils
has exact synonym: neutrophil programmed cell death by apoptosis
has exact synonym: programmed cell death of neutrophils by apoptosis
has exact synonym: programmed cell death, neutrophils
has related synonym: neutrophil apoptosis
type: Class
subclass of: part-of-parent-1780
subclass of: GO_0006925
subclass of: GO_0033028
subclass of: GO_0071887

B cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
has exact synonym: B lymphocyte homeostasis
has exact synonym: B-cell homeostasis
has exact synonym: B-lymphocyte homeostasis
type: Class
subclass of: lymphocyte homeostasis

B cell apoptotic process
IAO_0000115: Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
has exact synonym: B cell programmed cell death by apoptosis
has exact synonym: B lymphocyte apoptosis
has exact synonym: B lymphocyte programmed cell death by apoptosis
has exact synonym: B-cell apoptosis
has exact synonym: B-cell programmed cell death by apoptosis
has exact synonym: B-lymphocyte apoptosis
has exact synonym: B-lymphocyte programmed cell death by apoptosis
has exact synonym: apoptosis of B cells
has exact synonym: apoptosis of B lymphocytes
has exact synonym: apoptosis of B-cells
has exact synonym: apoptosis of B-lymphocytes
has exact synonym: programmed cell death of B cells by apoptosis
has exact synonym: programmed cell death of B lymphocytes by apoptosis
has exact synonym: programmed cell death of B-cells by apoptosis
has exact synonym: programmed cell death of B-lymphocytes by apoptosis
has exact synonym: programmed cell death, B cells
has exact synonym: programmed cell death, B lymphocytes
has exact synonym: programmed cell death, B-cells
has exact synonym: programmed cell death, B-lymphocytes
has related synonym: B cell apoptosis
type: Class
subclass of: GO_0070227

phosphotyrosine residue binding
IAO_0000115: Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
has related synonym: phosphotyrosine binding
type: Class
subclass of: GO_0045309

prostaglandin J receptor activity
IAO_0000115: Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.
has exact synonym: PGJ(2) receptor activity
has related synonym: PGJ receptor activity
type: Class
subclass of: GO_0004955

phosphatidylserine binding
IAO_0000115: Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
type: Class
subclass of: GO_0005543
subclass of: GO_0072341

natural killer cell proliferation
IAO_0000115: The expansion of a natural killer cell population by cell division.
has exact synonym: NK cell proliferation
type: Class
subclass of: GO_0030101
subclass of: GO_0046651

antibody-dependent cellular cytotoxicity
IAO_0000115: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
has exact synonym: ADCC
has exact synonym: antibody dependent cell death
has exact synonym: antibody dependent cell killing
has exact synonym: antibody-dependent cell death
has exact synonym: antibody-dependent cell killing
has exact synonym: type VI hypersensitivity
type: Class
subclass of: type IIa hypersensitivity
subclass of: leukocyte mediated cytotoxicity

polymeric immunoglobulin binding
IAO_0000115: Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.
type: Class
subclass of: GO_0019865

IgM binding
IAO_0000115: Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype.
type: Class
subclass of: GO_0019865

polymeric immunoglobulin receptor activity
IAO_0000115: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: GO_0019763

IgM receptor activity
IAO_0000115: Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: GO_0019763

type IIa hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.
type: Class
subclass of: type II hypersensitivity

type IIb hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
has exact synonym: type V hypersensitivity
type: Class
subclass of: type II hypersensitivity

regulation of type IIa hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.
type: Class
subclass of: regulation of type II hypersensitivity

negative regulation of type IIa hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type IIa hypersensitivity
has exact synonym: down-regulation of type IIa hypersensitivity
has exact synonym: downregulation of type IIa hypersensitivity
has related synonym: inhibition of type IIa hypersensitivity
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: negative regulation of type II hypersensitivity

positive regulation of type IIa hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type IIa hypersensitivity
has exact synonym: up-regulation of type IIa hypersensitivity
has exact synonym: upregulation of type IIa hypersensitivity
has related synonym: activation of type IIa hypersensitivity
has related synonym: stimulation of type IIa hypersensitivity
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: positive regulation of type II hypersensitivity

regulation of type IIb hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.
type: Class
subclass of: regulation of type II hypersensitivity

negative regulation of type IIb hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type IIb hypersensitivity
has exact synonym: down-regulation of type IIb hypersensitivity
has exact synonym: downregulation of type IIb hypersensitivity
has related synonym: inhibition of type IIb hypersensitivity
type: Class
subclass of: regulation of type IIb hypersensitivity
subclass of: negative regulation of type II hypersensitivity

positive regulation of type IIb hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type IIb hypersensitivity
has exact synonym: up-regulation of type IIb hypersensitivity
has exact synonym: upregulation of type IIb hypersensitivity
has related synonym: activation of type IIb hypersensitivity
has related synonym: stimulation of type IIb hypersensitivity
type: Class
subclass of: regulation of type IIb hypersensitivity
subclass of: positive regulation of type II hypersensitivity

type III hypersensitivity
IAO_0000115: An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue.
type: Class
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: GO_0016064

regulation of type III hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response

negative regulation of type III hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type III hypersensitivity
has exact synonym: down-regulation of type III hypersensitivity
has exact synonym: downregulation of type III hypersensitivity
has related synonym: inhibition of type III hypersensitivity
type: Class
subclass of: regulation of type III hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response

positive regulation of type III hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type III hypersensitivity
has exact synonym: up-regulation of type III hypersensitivity
has exact synonym: upregulation of type III hypersensitivity
has related synonym: activation of type III hypersensitivity
has related synonym: stimulation of type III hypersensitivity
type: Class
subclass of: regulation of type III hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response

type IV hypersensitivity
IAO_0000115: An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
has exact synonym: delayed hypersensitivity response
has exact synonym: delayed-type hypersensitivity
replaces: GO_0016069
type: Class
subclass of: T cell mediated immunity
subclass of: hypersensitivity

regulation of type IV hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of hypersensitivity

negative regulation of type IV hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type IV hypersensitivity
has exact synonym: down-regulation of type IV hypersensitivity
has exact synonym: downregulation of type IV hypersensitivity
has related synonym: inhibition of type IV hypersensitivity
type: Class
subclass of: regulation of type IV hypersensitivity
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of hypersensitivity

positive regulation of type IV hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type IV hypersensitivity
has exact synonym: up-regulation of type IV hypersensitivity
has exact synonym: upregulation of type IV hypersensitivity
has related synonym: activation of type IV hypersensitivity
has related synonym: stimulation of type IV hypersensitivity
type: Class
subclass of: regulation of type IV hypersensitivity
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of hypersensitivity

regulation of type I hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of immunoglobulin mediated immune response

negative regulation of type I hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.
has exact synonym: down regulation of type I hypersensitivity
has exact synonym: down-regulation of type I hypersensitivity
has exact synonym: downregulation of type I hypersensitivity
has related synonym: inhibition of type I hypersensitivity
type: Class
subclass of: regulation of type I hypersensitivity
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of immunoglobulin mediated immune response

positive regulation of type I hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
has exact synonym: up regulation of type I hypersensitivity
has exact synonym: up-regulation of type I hypersensitivity
has exact synonym: upregulation of type I hypersensitivity
has related synonym: activation of type I hypersensitivity
has related synonym: stimulation of type I hypersensitivity
type: Class
subclass of: regulation of type I hypersensitivity
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of immunoglobulin mediated immune response

regulation of antibody-dependent cellular cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.
has exact synonym: regulation of antibody dependent cell death
has exact synonym: regulation of antibody dependent cell killing
has exact synonym: regulation of antibody-dependent cell death
has exact synonym: regulation of antibody-dependent cell killing
type: Class
subclass of: regulation of type IIa hypersensitivity
subclass of: regulation of leukocyte mediated cytotoxicity

negative regulation of antibody-dependent cellular cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.
has exact synonym: down regulation of antibody-dependent cellular cytotoxicity
has exact synonym: down-regulation of antibody-dependent cellular cytotoxicity
has exact synonym: downregulation of antibody-dependent cellular cytotoxicity
has exact synonym: negative regulation of antibody dependent cell death
has exact synonym: negative regulation of antibody dependent cell killing
has exact synonym: negative regulation of antibody-dependent cell death
has exact synonym: negative regulation of antibody-dependent cell killing
has related synonym: inhibition of antibody-dependent cellular cytotoxicity
type: Class
subclass of: negative regulation of type IIa hypersensitivity
subclass of: regulation of antibody-dependent cellular cytotoxicity
subclass of: negative regulation of leukocyte mediated cytotoxicity

positive regulation of antibody-dependent cellular cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.
has exact synonym: positive regulation of antibody dependent cell death
has exact synonym: positive regulation of antibody dependent cell killing
has exact synonym: positive regulation of antibody-dependent cell death
has exact synonym: positive regulation of antibody-dependent cell killing
has exact synonym: up regulation of antibody-dependent cellular cytotoxicity
has exact synonym: up-regulation of antibody-dependent cellular cytotoxicity
has exact synonym: upregulation of antibody-dependent cellular cytotoxicity
has related synonym: activation of antibody-dependent cellular cytotoxicity
has related synonym: stimulation of antibody-dependent cellular cytotoxicity
type: Class
subclass of: positive regulation of type IIa hypersensitivity
subclass of: regulation of antibody-dependent cellular cytotoxicity
subclass of: positive regulation of leukocyte mediated cytotoxicity

cytokine production
IAO_0000115: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has related synonym: interferon production
has related synonym: interleukin production
type: Class
subclass of: GO_0010467
subclass of: GO_0032501

regulation of cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of production of a cytokine.
type: Class
subclass of: GO_0010468
subclass of: GO_0051239

negative regulation of cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the rate of production of a cytokine.
has exact synonym: down regulation of cytokine production
has exact synonym: down-regulation of cytokine production
has exact synonym: downregulation of cytokine production
has related synonym: inhibition of cytokine production
type: Class
subclass of: regulation of cytokine production
subclass of: GO_0010629
subclass of: GO_0051241

positive regulation of cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate or extent of production of a cytokine.
has exact synonym: up regulation of cytokine production
has exact synonym: up-regulation of cytokine production
has exact synonym: upregulation of cytokine production
has related synonym: activation of cytokine production
has related synonym: stimulation of cytokine production
type: Class
subclass of: regulation of cytokine production
subclass of: GO_0010628
subclass of: GO_0051240

serotonin secretion
IAO_0000115: The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
has exact synonym: 5-HT secretion
has exact synonym: 5-hydroxytryptamine secretion
has related synonym: serotonin release
type: Class
subclass of: GO_0006837
subclass of: GO_0023061

histamine secretion
IAO_0000115: The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.
type: Class
subclass of: GO_0046903
subclass of: GO_0051608

kidney development
IAO_0000115: The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
has related synonym: nephrogenesis
type: Class
subclass of: part-of-parent-72001
subclass of: GO_0048513

mesonephros development
IAO_0000115: The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
has exact synonym: Wolffian body development
type: Class
subclass of: kidney development

blastocyst development
IAO_0000115: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
type: Class
subclass of: part-of-parent-1701
subclass of: GO_0048856

blastocyst formation
IAO_0000115: The initial formation of a blastocyst from a solid ball of cells known as a morula.
type: Class
subclass of: part-of-parent-1824
subclass of: GO_0048646

inner cell mass cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.
type: Class
subclass of: part-of-parent-1825
subclass of: GO_0030154

inner cell mass cell fate commitment
IAO_0000115: The cell fate commitment of precursor cells that will become inner cell mass cells.
type: Class
subclass of: part-of-parent-1826
subclass of: GO_0045165

inner cell mass cellular morphogenesis
IAO_0000115: The morphogenesis of cells in the inner cell mass.
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: part-of-parent-1826
subclass of: GO_0048598

trophectodermal cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
has exact synonym: trophectoderm cell differentiation
type: Class
subclass of: part-of-parent-1825
subclass of: GO_0030154

trophectodermal cell fate commitment
IAO_0000115: The cell fate commitment of precursor cells that will become trophectoderm cells.
has exact synonym: trophectoderm cell fate commitment
type: Class
subclass of: part-of-parent-1829
subclass of: GO_0045165

trophectodermal cellular morphogenesis
IAO_0000115: The morphogenesis of trophectoderm cells.
has exact synonym: trophectoderm cellular morphogenesis
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: part-of-parent-1829
subclass of: GO_0048598

blastocyst growth
IAO_0000115: An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
type: Class
subclass of: part-of-parent-1824
subclass of: GO_0048589

inner cell mass cell proliferation
IAO_0000115: The proliferation of cells in the inner cell mass.
type: Class
subclass of: part-of-parent-1832
subclass of: GO_0008283

trophectodermal cell proliferation
IAO_0000115: The proliferation of cells in the trophectoderm.
has exact synonym: trophectoderm cell proliferation
type: Class
subclass of: part-of-parent-1832
subclass of: GO_0008283

blastocyst hatching
IAO_0000115: The hatching of the cellular blastocyst from the zona pellucida.
type: Class
subclass of: part-of-parent-1824
subclass of: GO_0035188

release of cytochrome c from mitochondria
IAO_0000115: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
type: Class
subclass of: part-of-parent-97190
subclass of: GO_0008637

epithelial to mesenchymal transition
IAO_0000115: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
has exact synonym: EMT
has exact synonym: epithelial-mesenchymal transition
has exact synonym: mesenchymal cell differentiation from epithelial cell
type: Class
subclass of: GO_0048762

embryonic epithelial tube formation
IAO_0000115: The morphogenesis of an embryonic epithelium into a tube-shaped structure.
type: Class
subclass of: part-of-parent-16331
subclass of: GO_0072175

neural plate morphogenesis
IAO_0000115: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
type: Class
subclass of: part-of-parent-1840
subclass of: GO_0016331

neural plate development
IAO_0000115: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
type: Class
subclass of: part-of-parent-43009
subclass of: GO_0060429

neural tube formation
IAO_0000115: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
has exact synonym: neural tube morphogenesis
has exact synonym: neurulation
replaces: GO_0001679
type: Class
subclass of: embryonic epithelial tube formation
subclass of: part-of-parent-21915

neural fold formation
IAO_0000115: The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.
has related synonym: neural groove formation
type: Class
subclass of: part-of-parent-14020
subclass of: GO_0016331
subclass of: GO_0048646
subclass of: GO_0060571

neural tube closure
IAO_0000115: The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
type: Class
subclass of: part-of-parent-14020
subclass of: GO_0060606

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
IAO_0000115: The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.
has related synonym: insertion of proteins into mitochondrial membranes during the induction of apoptosis
has related synonym: protein insertion into mitochondrial membrane during induction of apoptosis
has related synonym: protein insertion into mitochondrial membrane involved in induction of apoptosis
has related synonym: protein insertion into mitochondrion membrane during induction of apoptosis
type: Class
subclass of: part-of-parent-97190
subclass of: part-of-parent-97345
subclass of: GO_0051204

phagolysosome assembly
IAO_0000115: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
has related synonym: late phagosome biosynthesis
has related synonym: late phagosome formation
has related synonym: phagolysosome formation
type: Class
subclass of: part-of-parent-6909
subclass of: part-of-parent-90382
subclass of: GO_0007040
subclass of: GO_0016050
subclass of: GO_0070925

opsonin binding
IAO_0000115: Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.
type: Class
subclass of: GO_0005515

opsonin receptor activity
IAO_0000115: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: GO_0004888

complement binding
IAO_0000115: Interacting selectively and non-covalently with any component or product of the complement cascade.
type: Class
subclass of: GO_0005515

complement component C1q complex binding
IAO_0000115: Interacting selectively and non-covalently with the C1q complex, a component of the classical complement cascade.
type: Class
subclass of: opsonin binding
subclass of: complement binding
subclass of: GO_0044877

complement component C3a binding
IAO_0000115: Interacting selectively and non-covalently with the C3a product of the complement cascade.
type: Class
subclass of: complement binding

complement component C3b binding
IAO_0000115: Interacting selectively and non-covalently with the C3b product of the complement cascade.
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component iC3b binding
IAO_0000115: Interacting selectively and non-covalently with the iC3b product of the complement cascade.
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component C3dg binding
IAO_0000115: Interacting selectively and non-covalently with the C3dg product of the complement cascade.
type: Class
subclass of: complement binding

complement component C3d binding
IAO_0000115: Interacting selectively and non-covalently with the C3d product of the complement cascade.
type: Class
subclass of: complement binding

complement component C4b binding
IAO_0000115: Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
type: Class
subclass of: opsonin binding
subclass of: complement binding

complement component C5a binding
IAO_0000115: Interacting selectively and non-covalently with the C5a product of the complement cascade.
type: Class
subclass of: complement binding

complement component C1q receptor activity
IAO_0000115: Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875

complement component iC3b receptor activity
IAO_0000115: Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875

complement component C3dg receptor activity
IAO_0000115: Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: GO_0004875

complement component C3d receptor activity
IAO_0000115: Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: GO_0004875

complement component C4b receptor activity
IAO_0000115: Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: opsonin receptor activity
subclass of: GO_0004875

collectin binding
IAO_0000115: Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.
type: Class
subclass of: opsonin binding

collectin receptor activity
IAO_0000115: Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type: Class
subclass of: opsonin receptor activity

pentraxin binding
IAO_0000115: Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.
type: Class
subclass of: opsonin binding

NK T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a NK T cell.
has exact synonym: NK T lymphocyte differentiation
has exact synonym: NK T-cell differentiation
has exact synonym: NK T-lymphocyte differentiation
has exact synonym: NKT cell differentiation
has exact synonym: NT cell differentiation
has exact synonym: natural T cell differentiation
has exact synonym: natural killer T cell differentiation
has related synonym: NK T cell development
type: Class
subclass of: GO_0046632

NK T cell proliferation
IAO_0000115: The expansion of a NK T cell population by cell division.
has exact synonym: NK T lymphocyte proliferation
has exact synonym: NK T-cell proliferation
has exact synonym: NK T-lymphocyte proliferation
has exact synonym: NKT cell proliferation
has exact synonym: NT cell proliferation
has exact synonym: natural T cell proliferation
has exact synonym: natural killer T cell proliferation
type: Class
subclass of: GO_0046633
subclass of: GO_0051132

complement activation, lectin pathway
IAO_0000115: Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
has exact synonym: complement cascade, lectin pathway
type: Class
subclass of: GO_0006956
subclass of: GO_0045087

regulation of complement activation, lectin pathway
IAO_0000115: Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.
has exact synonym: regulation of complement cascade, lectin pathway
type: Class
subclass of: GO_0030449
subclass of: GO_0045088

negative regulation of complement activation, lectin pathway
IAO_0000115: Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
has exact synonym: down regulation of complement activation, lectin pathway
has exact synonym: down-regulation of complement activation, lectin pathway
has exact synonym: downregulation of complement activation, lectin pathway
has exact synonym: negative regulation of complement cascade, lectin pathway
has related synonym: inhibition of complement activation, lectin pathway
type: Class
subclass of: regulation of complement activation, lectin pathway
subclass of: GO_0045824
subclass of: GO_0045916

positive regulation of complement activation, lectin pathway
IAO_0000115: Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.
has exact synonym: positive regulation of complement cascade, lectin pathway
has exact synonym: up regulation of complement activation, lectin pathway
has exact synonym: up-regulation of complement activation, lectin pathway
has exact synonym: upregulation of complement activation, lectin pathway
has related synonym: activation of complement activation, lectin pathway
has related synonym: stimulation of complement activation, lectin pathway
type: Class
subclass of: regulation of complement activation, lectin pathway
subclass of: GO_0045089
subclass of: GO_0045917

obsolete pattern binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.
type: Class
subclass of: ObsoleteClass

(1->3)-beta-D-glucan binding
IAO_0000115: Interacting selectively and non-covalently with (1->3)-beta-D-glucans.
has exact synonym: 1,3-beta-D-glucan binding
has related synonym: callose binding
has related synonym: zymosan binding
replaces: GO_0080087
type: Class
subclass of: GO_0030247

polysaccharide immune receptor activity
IAO_0000115: Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
has related synonym: polysaccharide receptor activity
type: Class
subclass of: GO_0038187

(1->3)-beta-D-glucan immune receptor activity
IAO_0000115: Combining with (1->3)-beta-D-glucans to initiate an innate immune response.
has exact synonym: (1,3)-beta-D-glucan receptor activity
has exact synonym: 1,3-beta-D-glucan receptor activity
has exact synonym: beta-1,3-D-glucan receptor activity
has related synonym: (1->3)-beta-D-glucan receptor activity
has related synonym: zymosan receptor activity
type: Class
subclass of: polysaccharide immune receptor activity

lipopolysaccharide immune receptor activity
IAO_0000115: Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
has exact synonym: LPS receptor activity
has related synonym: endotoxin receptor activity
has related synonym: lipopolysaccharide receptor activity
type: Class
subclass of: part-of-parent-31663
subclass of: GO_0038187

lipoarabinomannan binding
IAO_0000115: Interacting selectively and non-covalently with lipoarabinomannan.
has exact synonym: LAM binding
type: Class
subclass of: GO_0034235

lipoarabinomannan immune receptor activity
IAO_0000115: Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response.
has exact synonym: LAM receptor activity
has related synonym: lipoarabinomannan receptor activity
type: Class
subclass of: GO_0038187

response to yeast
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
type: Class
subclass of: GO_0009620

detection of yeast
IAO_0000115: The series of events in which a stimulus from a yeast is received and converted into a molecular signal.
type: Class
subclass of: response to yeast
subclass of: GO_0016046

Mullerian duct regression
IAO_0000115: The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.
type: Class
subclass of: part-of-parent-46661
subclass of: developmental process involved in reproduction
subclass of: GO_0060033

receptor recycling
IAO_0000115: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
type: Class
subclass of: GO_0043112

nucleoside binding
IAO_0000115: Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
type: Class
subclass of: GO_0036094
subclass of: GO_0097159
subclass of: GO_0097367
subclass of: GO_1901363

purine nucleoside binding
IAO_0000115: Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.
type: Class
subclass of: nucleoside binding

pyrimidine nucleoside binding
IAO_0000115: Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose.
type: Class
subclass of: nucleoside binding

endothelial cell development
IAO_0000115: The progression of an endothelial cell over time, from its formation to the mature structure.
type: Class
subclass of: part-of-parent-45446
subclass of: epithelial cell development

endothelial cell morphogenesis
IAO_0000115: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
type: Class
subclass of: part-of-parent-1885
subclass of: epithelial cell morphogenesis

selenium compound metabolic process
IAO_0000115: The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
has exact synonym: selenium compound metabolism
has exact synonym: selenium metabolic process
has exact synonym: selenium metabolism
type: Class
subclass of: GO_0044237

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.
has exact synonym: UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: alpha-1,4-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-N-acetylglucosaminyltransferase I activity
has exact synonym: alpha1,4-N-acetylglucosaminyltransferase activity
has exact synonym: glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375

liver development
IAO_0000115: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
type: Class
subclass of: part-of-parent-61008
subclass of: GO_0048732

placenta development
IAO_0000115: The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has exact synonym: placental development
has exact synonym: placentation
type: Class
subclass of: GO_0048513
subclass of: GO_0048608

phagocytic cup
IAO_0000115: An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
type: Class
subclass of: part-of-parent-5886
subclass of: GO_0110165

embryonic placenta development
IAO_0000115: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has exact synonym: fetal placenta development
type: Class
subclass of: part-of-parent-1701
subclass of: part-of-parent-1890
subclass of: developmental process involved in reproduction
subclass of: GO_0048568

maternal placenta development
IAO_0000115: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
has related synonym: decidua development
type: Class
subclass of: part-of-parent-1890
subclass of: developmental process involved in reproduction
subclass of: GO_0048856
subclass of: GO_0060135

tissue homeostasis
IAO_0000115: A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
has related synonym: tissue maintenance
type: Class
subclass of: part-of-parent-48871
subclass of: GO_0060249

retina homeostasis
IAO_0000115: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.
type: Class
subclass of: tissue homeostasis

autolysis
IAO_0000115: A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.
type: Class
subclass of: GO_0012501

cytolysis by symbiont of host cells
IAO_0000115: The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: cytolysis by organism of host cells
type: Class
subclass of: killing by symbiont of host cells
subclass of: GO_0051801

regulation of cytolysis by symbiont of host cells
IAO_0000115: Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: regulation by symbiont of cytolysis of host cells
type: Class
subclass of: GO_0043903
subclass of: GO_0051802

negative regulation of cytolysis by symbiont of host cells
IAO_0000115: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: down regulation by symbiont of cytolysis of host cells
has exact synonym: down-regulation by symbiont of cytolysis of host cells
has exact synonym: downregulation by symbiont of cytolysis of host cells
has exact synonym: negative regulation by symbiont of cytolysis of host cells
has related synonym: inhibition by symbiont of cytolysis of host cells
type: Class
subclass of: regulation of cytolysis by symbiont of host cells
subclass of: GO_0051803

positive regulation of cytolysis by symbiont of host cells
IAO_0000115: Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has exact synonym: positive regulation by symbiont of cytolysis of host cells
has exact synonym: up regulation by symbiont of cytolysis of host cells
has exact synonym: up-regulation by symbiont of cytolysis of host cells
has exact synonym: upregulation by symbiont of cytolysis of host cells
has related synonym: activation by symbiont of cytolysis of host cells
has related synonym: stimulation by symbiont of cytolysis of host cells
type: Class
subclass of: regulation of cytolysis by symbiont of host cells
subclass of: GO_0051804

activation of membrane attack complex
IAO_0000115: The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
has exact synonym: MAC assembly
has exact synonym: MAC formation
has exact synonym: activation of MAC
has exact synonym: membrane attack complex assembly
has exact synonym: membrane attack complex formation
has related synonym: activation of TCC
has related synonym: activation of terminal complement complex
has related synonym: activation of the terminal complement cascade
type: Class
subclass of: GO_0006956

cell killing
IAO_0000115: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
has related synonym: necrosis
type: Class
subclass of: GO_0009987

killing by symbiont of host cells
IAO_0000115: Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
type: Class
subclass of: GO_0051701
subclass of: GO_0051883

leukocyte mediated cytotoxicity
IAO_0000115: The directed killing of a target cell by a leukocyte.
has exact synonym: immune cell mediated cell death
has exact synonym: immune cell mediated cell killing
has exact synonym: immune cell mediated cytotoxicity
has exact synonym: leucocyte mediated cytotoxicity
type: Class
subclass of: cell killing
subclass of: leukocyte mediated immunity

regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
has exact synonym: regulation of immune cell mediated cell death
has exact synonym: regulation of immune cell mediated cell killing
has exact synonym: regulation of immune cell mediated cytotoxicity
has exact synonym: regulation of leucocyte mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated immunity
subclass of: GO_0031341

negative regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
has exact synonym: down regulation of leukocyte mediated cytotoxicity
has exact synonym: down-regulation of leukocyte mediated cytotoxicity
has exact synonym: downregulation of leukocyte mediated cytotoxicity
has exact synonym: negative regulation of immune cell mediated cytotoxicity
has exact synonym: negative regulation of leucocyte mediated cytotoxicity
has related synonym: inhibition of leukocyte mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: negative regulation of leukocyte mediated immunity
subclass of: GO_0031342

positive regulation of leukocyte mediated cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
has exact synonym: positive regulation of immune cell mediated cytotoxicity
has exact synonym: positive regulation of leucocyte mediated cytotoxicity
has exact synonym: up regulation of leukocyte mediated cytotoxicity
has exact synonym: up-regulation of leukocyte mediated cytotoxicity
has exact synonym: upregulation of leukocyte mediated cytotoxicity
has related synonym: activation of leukocyte mediated cytotoxicity
has related synonym: stimulation of leukocyte mediated cytotoxicity
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: positive regulation of leukocyte mediated immunity
subclass of: GO_0031343

T cell mediated cytotoxicity
IAO_0000115: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: T cell mediated apoptosis
has exact synonym: T cell mediated cell death
has exact synonym: T cell mediated cell killing
has exact synonym: T lymphocyte mediated cytotoxicity
has exact synonym: T-cell mediated apoptosis
has exact synonym: T-cell mediated cell death
has exact synonym: T-cell mediated cell killing
has exact synonym: T-cell mediated cytotoxicity
has exact synonym: T-lymphocyte mediated cytotoxicity
has related synonym: T cell mediated cytolysis
type: Class
subclass of: leukocyte mediated cytotoxicity
subclass of: T cell mediated immunity

regulation of T cell mediated cytotoxicity
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
has exact synonym: regulation of T cell mediated apoptosis
has exact synonym: regulation of T cell mediated cell death
has exact synonym: regulation of T cell mediated cell killing
has exact synonym: regulation of T lymphocyte mediated cytotoxicity
has exact synonym: regulation of T-cell mediated apoptosis
has exact synonym: regulation of T-cell mediated cell death
has exact synonym: regulation of T-cell mediated cell killing
has exact synonym: regulation of T-cell mediated cytotoxicity
has exact synonym: regulation of T-lymphocyte mediated cytotoxicity
has related synonym: regulation of T cell mediated cytolysis
has related synonym: regulation of T-cell mediated cytolysis
type: Class
subclass of: regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated immunity

negative regulation of T cell mediated cytotoxicity
IAO_0000115: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
has exact synonym: down regulation of T cell mediated cytotoxicity
has exact synonym: down-regulation of T cell mediated cytotoxicity
has exact synonym: downregulation of T cell mediated cytotoxicity
has exact synonym: negative regulation of T cell mediated apoptosis
has exact synonym: negative regulation of T cell mediated cell death
has exact synonym: negative regulation of T cell mediated cell killing
has exact synonym: negative regulation of T lymphocyte mediated cytotoxicity
has exact synonym: negative regulation of T-cell mediated apoptosis
has exact synonym: negative regulation of T-cell mediated cell death
has exact synonym: negative regulation of T-cell mediated cell killing
has exact synonym: negative regulation of T-cell mediated cytotoxicity
has exact synonym: negative regulation of T-lymphocyte mediated cytotoxicity
has related synonym: inhibition of T cell mediated cytotoxicity
has related synonym: negative regulation of T cell mediated cytolysis
has related synonym: negative regulation of T-cell mediated cytolysis
type: Class
subclass of: negative regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated cytotoxicity
subclass of: negative regulation of T cell mediated immunity

positive regulation of T cell mediated cytotoxicity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
has exact synonym: positive regulation of T cell mediated apoptosis
has exact synonym: positive regulation of T cell mediated cell death
has exact synonym: positive regulation of T cell mediated cell killing
has exact synonym: positive regulation of T lymphocyte mediated cytotoxicity
has exact synonym: positive regulation of T-cell mediated apoptosis
has exact synonym: positive regulation of T-cell mediated cell death
has exact synonym: positive regulation of T-cell mediated cell killing
has exact synonym: positive regulation of T-cell mediated cytotoxicity
has exact synonym: positive regulation of T-lymphocyte mediated cytotoxicity
has exact synonym: up regulation of T cell mediated cytotoxicity
has exact synonym: up-regulation of T cell mediated cytotoxicity
has exact synonym: upregulation of T cell mediated cytotoxicity
has related synonym: activation of T cell mediated cytotoxicity
has related synonym: positive regulation of T cell mediated cytolysis
has related synonym: positive regulation of T-cell mediated cytolysis
has related synonym: stimulation of T cell mediated cytotoxicity
type: Class
subclass of: positive regulation of leukocyte mediated cytotoxicity
subclass of: regulation of T cell mediated cytotoxicity
subclass of: positive regulation of T cell mediated immunity

photoreceptor inner segment
IAO_0000115: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
type: Class
subclass of: GO_0110165

farnesylated protein binding
IAO_0000115: Interacting selectively and non-covalently with a farnesylated protein.
type: Class
subclass of: GO_0005515

regulation of receptor recycling
IAO_0000115: Any process that modulates the frequency, rate, or extent of receptor recycling.
type: Class
subclass of: GO_0023051
subclass of: GO_0031323
subclass of: GO_0060255

negative regulation of receptor recycling
IAO_0000115: Any process that stops, prevents, or reduces the rate of receptor recycling.
has exact synonym: down regulation of receptor recycling
has exact synonym: down-regulation of receptor recycling
has exact synonym: downregulation of receptor recycling
has related synonym: inhibition of receptor recycling
type: Class
subclass of: regulation of receptor recycling
subclass of: GO_0010605
subclass of: GO_0023057
subclass of: GO_0031324

positive regulation of receptor recycling
IAO_0000115: Any process that activates or increases the frequency, rate or extent of receptor recycling.
has exact synonym: up regulation of receptor recycling
has exact synonym: up-regulation of receptor recycling
has exact synonym: upregulation of receptor recycling
has related synonym: activation of receptor recycling
has related synonym: stimulation of receptor recycling
type: Class
subclass of: regulation of receptor recycling
subclass of: GO_0010604
subclass of: GO_0023056
subclass of: GO_0031325

B-1 B cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: B-1 B lymphocyte homeostasis
has exact synonym: B-1 B-cell homeostasis
has exact synonym: B-1 B-lymphocyte homeostasis
type: Class
subclass of: B cell homeostasis

B-1 B cell differentiation
IAO_0000115: The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: B-1 B lymphocyte differentiation
has exact synonym: B-1 B-cell differentiation
has exact synonym: B-1 B-lymphocyte differentiation
has related synonym: B-1 B cell development
type: Class
subclass of: mature B cell differentiation

regulation of B-1 B cell differentiation
IAO_0000115: Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
has exact synonym: regulation of B-1 B lymphocyte differentiation
has exact synonym: regulation of B-1 B-cell differentiation
has exact synonym: regulation of B-1 B-lymphocyte differentiation
has related synonym: regulation of B-1 B cell development
type: Class
subclass of: GO_0045577

negative regulation of B-1 B cell differentiation
IAO_0000115: Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.
has exact synonym: down regulation of B-1 B cell differentiation
has exact synonym: down-regulation of B-1 B cell differentiation
has exact synonym: downregulation of B-1 B cell differentiation
has exact synonym: negative regulation of B-1 B lymphocyte differentiation
has exact synonym: negative regulation of B-1 B-cell differentiation
has exact synonym: negative regulation of B-1 B-lymphocyte differentiation
has related synonym: inhibition of B-1 B cell differentiation
has related synonym: negative regulation of B-1 B cell development
type: Class
subclass of: regulation of B-1 B cell differentiation
subclass of: GO_0045578

positive regulation of B-1 B cell differentiation
IAO_0000115: Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation.
has exact synonym: positive regulation of B-1 B lymphocyte differentiation
has exact synonym: positive regulation of B-1 B-cell differentiation
has exact synonym: positive regulation of B-1 B-lymphocyte differentiation
has exact synonym: up regulation of B-1 B cell differentiation
has exact synonym: up-regulation of B-1 B cell differentiation
has exact synonym: upregulation of B-1 B cell differentiation
has related synonym: activation of B-1 B cell differentiation
has related synonym: positive regulation of B-1 B cell development
has related synonym: stimulation of B-1 B cell differentiation
type: Class
subclass of: regulation of B-1 B cell differentiation
subclass of: GO_0045579

exocyst assembly
IAO_0000115: The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.
type: Class
subclass of: part-of-parent-6904
subclass of: GO_0034622
subclass of: GO_0140029

regulation of exocyst assembly
IAO_0000115: Any process that modulates the frequency, rate or extent of exocyst assembly.
type: Class
subclass of: GO_0017157
subclass of: GO_0043254
subclass of: GO_0106020

negative regulation of exocyst assembly
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of exocyst assembly.
has exact synonym: down regulation of exocyst assembly
has exact synonym: down-regulation of exocyst assembly
has exact synonym: downregulation of exocyst assembly
has related synonym: inhibition of exocyst assembly
type: Class
subclass of: regulation of exocyst assembly
subclass of: GO_0031333
subclass of: GO_0045920
subclass of: GO_0106021

positive regulation of exocyst assembly
IAO_0000115: Any process that increases the rate or extent of exocyst assembly.
has exact synonym: up regulation of exocyst assembly
has exact synonym: up-regulation of exocyst assembly
has exact synonym: upregulation of exocyst assembly
has related synonym: activation of exocyst assembly
has related synonym: stimulation of exocyst assembly
type: Class
subclass of: regulation of exocyst assembly
subclass of: GO_0031334
subclass of: GO_0045921
subclass of: GO_0106022

uropod
IAO_0000115: A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.
has exact synonym: uropodium
has related synonym: distal pole complex
has related synonym: retractile pole
type: Class
subclass of: part-of-parent-31254
subclass of: GO_0120025

regulation of protein phosphorylation
IAO_0000115: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
has exact synonym: regulation of protein amino acid phosphorylation
type: Class
subclass of: GO_0031399
subclass of: GO_0042325

negative regulation of protein phosphorylation
IAO_0000115: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
has exact synonym: down regulation of protein amino acid phosphorylation
has exact synonym: down-regulation of protein amino acid phosphorylation
has exact synonym: downregulation of protein amino acid phosphorylation
has exact synonym: negative regulation of protein amino acid phosphorylation
has related synonym: inhibition of protein amino acid phosphorylation
type: Class
subclass of: regulation of protein phosphorylation
subclass of: GO_0031400
subclass of: GO_0042326

positive regulation of protein phosphorylation
IAO_0000115: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
has exact synonym: positive regulation of protein amino acid phosphorylation
has exact synonym: up regulation of protein amino acid phosphorylation
has exact synonym: up-regulation of protein amino acid phosphorylation
has exact synonym: upregulation of protein amino acid phosphorylation
has related synonym: activation of protein amino acid phosphorylation
has related synonym: stimulation of protein amino acid phosphorylation
type: Class
subclass of: regulation of protein phosphorylation
subclass of: GO_0031401
subclass of: GO_0042327

endothelial cell proliferation
IAO_0000115: The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
type: Class
subclass of: GO_0050673

regulation of endothelial cell proliferation
IAO_0000115: Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.
type: Class
subclass of: GO_0050678

negative regulation of endothelial cell proliferation
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
has exact synonym: down regulation of endothelial cell proliferation
has exact synonym: down-regulation of endothelial cell proliferation
has exact synonym: downregulation of endothelial cell proliferation
has related synonym: inhibition of endothelial cell proliferation
type: Class
subclass of: regulation of endothelial cell proliferation
subclass of: GO_0050680

positive regulation of endothelial cell proliferation
IAO_0000115: Any process that activates or increases the rate or extent of endothelial cell proliferation.
has exact synonym: up regulation of endothelial cell proliferation
has exact synonym: up-regulation of endothelial cell proliferation
has exact synonym: upregulation of endothelial cell proliferation
has related synonym: activation of endothelial cell proliferation
has related synonym: stimulation of endothelial cell proliferation
type: Class
subclass of: regulation of endothelial cell proliferation
subclass of: GO_0050679

female pronucleus
IAO_0000115: The pronucleus originating from the ovum that is being fertilized.
type: Class
subclass of: GO_0045120

male pronucleus
IAO_0000115: The pronucleus originating from the spermatozoa that was involved in fertilization.
type: Class
subclass of: GO_0045120

postsynaptic membrane organization
IAO_0000115: A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
has exact synonym: post-synaptic membrane organization
has exact synonym: postsynaptic membrane organisation
type: Class
subclass of: part-of-parent-99173
subclass of: GO_0061024

hair follicle development
IAO_0000115: The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
replaces: GO_0001943
type: Class
subclass of: part-of-parent-98773
subclass of: GO_0022405
subclass of: GO_0048856

vasculature development
IAO_0000115: The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
has related synonym: vascular system development
type: Class
subclass of: part-of-parent-72359
subclass of: GO_0048731

lymph vessel development
IAO_0000115: The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
type: Class
subclass of: part-of-parent-1944
subclass of: GO_0048856

lymphangiogenesis
IAO_0000115: Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
has exact synonym: lymph vessel formation
type: Class
subclass of: part-of-parent-36303
subclass of: GO_0009653
subclass of: GO_0048646

heart looping
IAO_0000115: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
has exact synonym: cardiac looping
type: Class
subclass of: part-of-parent-61371
subclass of: embryonic heart tube morphogenesis

sebaceous gland cell differentiation
IAO_0000115: The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.
has related synonym: sebocytes differentiation
type: Class
subclass of: part-of-parent-48733
subclass of: GO_0009913

obsolete plasma membrane enriched fraction
IAO_0000115: OBSOLETE. The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes.
type: Class
subclass of: ObsoleteClass

intestinal D-glucose absorption
IAO_0000115: Uptake of D-glucose into the blood by absorption from the small intestine.
type: Class
subclass of: GO_0106001

regulation of cell-matrix adhesion
IAO_0000115: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.
type: Class
subclass of: GO_0010810

negative regulation of cell-matrix adhesion
IAO_0000115: Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
has exact synonym: down regulation of cell-matrix adhesion
has exact synonym: down-regulation of cell-matrix adhesion
has exact synonym: downregulation of cell-matrix adhesion
has related synonym: inhibition of cell-matrix adhesion
type: Class
subclass of: regulation of cell-matrix adhesion
subclass of: GO_0010812

positive regulation of cell-matrix adhesion
IAO_0000115: Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
has exact synonym: up regulation of cell-matrix adhesion
has exact synonym: up-regulation of cell-matrix adhesion
has exact synonym: upregulation of cell-matrix adhesion
has related synonym: activation of cell-matrix adhesion
has related synonym: stimulation of cell-matrix adhesion
type: Class
subclass of: regulation of cell-matrix adhesion
subclass of: GO_0010811

blood vessel maturation
IAO_0000115: A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
type: Class
subclass of: part-of-parent-1568
subclass of: GO_0071695

positive regulation of neurotransmitter secretion
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
has exact synonym: up regulation of neurotransmitter secretion
has exact synonym: up-regulation of neurotransmitter secretion
has exact synonym: upregulation of neurotransmitter secretion
has related synonym: activation of neurotransmitter secretion
has related synonym: stimulation of neurotransmitter secretion
type: Class
subclass of: GO_0046928
subclass of: GO_0050806
subclass of: GO_0051590
subclass of: GO_1903532

intramembranous ossification
IAO_0000115: Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.
has related synonym: dermal ossification
has related synonym: intramembranous bone ossification
type: Class
subclass of: GO_0036072

endochondral ossification
IAO_0000115: Replacement ossification wherein bone tissue replaces cartilage.
type: Class
subclass of: part-of-parent-60350
subclass of: GO_0036075

regulation of cytokine-mediated signaling pathway
IAO_0000115: Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
has exact synonym: regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: regulation of cytokine mediated signaling pathway
has exact synonym: regulation of cytokine mediated signalling pathway
type: Class
subclass of: GO_0009966
subclass of: GO_0060759

negative regulation of cytokine-mediated signaling pathway
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
has exact synonym: down regulation of cytokine mediated signaling pathway
has exact synonym: down-regulation of cytokine mediated signaling pathway
has exact synonym: downregulation of cytokine mediated signaling pathway
has exact synonym: negative regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: negative regulation of cytokine mediated signaling pathway
has exact synonym: negative regulation of cytokine mediated signalling pathway
has related synonym: inhibition of cytokine mediated signaling pathway
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: GO_0009968
subclass of: GO_0060761

positive regulation of cytokine-mediated signaling pathway
IAO_0000115: Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
has exact synonym: positive regulation of cytokine and chemokine mediated signaling pathway
has exact synonym: positive regulation of cytokine mediated signaling pathway
has exact synonym: positive regulation of cytokine mediated signalling pathway
has exact synonym: up regulation of cytokine mediated signaling pathway
has exact synonym: up-regulation of cytokine mediated signaling pathway
has exact synonym: upregulation of cytokine mediated signaling pathway
has related synonym: activation of cytokine mediated signaling pathway
has related synonym: stimulation of cytokine mediated signaling pathway
type: Class
subclass of: regulation of cytokine-mediated signaling pathway
subclass of: GO_0009967
subclass of: GO_0060760

alpha-1,3-galactosyltransferase activity
IAO_0000115: Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage.
has related synonym: isoglobotriaosylceramide synthase
type: Class
subclass of: GO_0008378

synaptic transmission, dopaminergic
IAO_0000115: The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
has exact synonym: dopaminergic synaptic transmission
type: Class
subclass of: GO_0007268

startle response
IAO_0000115: An action or movement due to the application of a sudden unexpected stimulus.
type: Class
subclass of: GO_0009605
subclass of: GO_0050905

G-protein alpha-subunit binding
IAO_0000115: Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
has exact synonym: G-alpha protein subunit binding
type: Class
subclass of: GO_0005515

thigmotaxis
IAO_0000115: The directed movement of a motile cell or organism in response to touch.
has exact synonym: stereotaxis
has exact synonym: taxis in response to touch stimulus
has related synonym: taxis in response to mechanical stimulus
type: Class
subclass of: GO_0042330

suckling behavior
IAO_0000115: Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.
has exact synonym: nursing behavior
type: Class
subclass of: GO_0007631

fibronectin binding
IAO_0000115: Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
type: Class
subclass of: GO_0005515

regulation of activation of membrane attack complex
IAO_0000115: Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: regulation of MAC assembly
has exact synonym: regulation of MAC formation
has exact synonym: regulation of activation of MAC
has exact synonym: regulation of membrane attack complex assembly
has exact synonym: regulation of membrane attack complex formation
has related synonym: regulation of activation of TCC
has related synonym: regulation of activation of terminal complement complex
has related synonym: regulation of activation of the terminal complement cascade
type: Class
subclass of: GO_0030449

positive regulation of activation of membrane attack complex
IAO_0000115: Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: positive regulation of MAC assembly
has exact synonym: positive regulation of MAC formation
has exact synonym: positive regulation of activation of MAC
has exact synonym: positive regulation of membrane attack complex assembly
has exact synonym: positive regulation of membrane attack complex formation
has exact synonym: up regulation of activation of membrane attack complex
has exact synonym: up-regulation of activation of membrane attack complex
has exact synonym: upregulation of activation of membrane attack complex
has related synonym: activation of activation of membrane attack complex
has related synonym: positive regulation of activation of TCC
has related synonym: positive regulation of activation of terminal complement complex
has related synonym: positive regulation of activation of the terminal complement cascade
has related synonym: stimulation of activation of membrane attack complex
type: Class
subclass of: regulation of activation of membrane attack complex
subclass of: GO_0045917

negative regulation of activation of membrane attack complex
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
has exact synonym: down regulation of activation of membrane attack complex
has exact synonym: down-regulation of activation of membrane attack complex
has exact synonym: downregulation of activation of membrane attack complex
has exact synonym: negative regulation of MAC assembly
has exact synonym: negative regulation of MAC formation
has exact synonym: negative regulation of activation of MAC
has exact synonym: negative regulation of membrane attack complex assembly
has exact synonym: negative regulation of membrane attack complex formation
has related synonym: inhibition of activation of membrane attack complex
has related synonym: negative regulation of activation of TCC
has related synonym: negative regulation of activation of terminal complement complex
has related synonym: negative regulation of activation of the terminal complement cascade
type: Class
subclass of: regulation of activation of membrane attack complex
subclass of: GO_0045916

retinoic acid binding
IAO_0000115: Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.
type: Class
subclass of: GO_0005501
subclass of: GO_0033293

G protein-coupled adenosine receptor signaling pathway
IAO_0000115: The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
has exact synonym: P1 receptor signaling pathway
has exact synonym: adenosine receptor signaling pathway, G-protein coupled
has exact synonym: adenosine receptor signalling pathway
has related synonym: adenosine receptor signaling pathway
type: Class
subclass of: GO_0035588

blood vessel remodeling
IAO_0000115: The reorganization or renovation of existing blood vessels.
type: Class
subclass of: GO_0048771

response to amphetamine
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
type: Class
subclass of: GO_0014075

nervous system process involved in regulation of systemic arterial blood pressure
IAO_0000115: The regulation of blood pressure mediated by detection of stimuli and a neurological response.
has exact synonym: blood pressure regulation by neurological process
has exact synonym: neurological process involved in regulation of systemic arterial blood pressure
has exact synonym: neurological system process involved in regulation of systemic arterial blood pressure
has related synonym: fast control of arterial pressure
type: Class
subclass of: part-of-parent-3073
subclass of: GO_0050877

renal system process involved in regulation of blood volume
IAO_0000115: A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.
has related synonym: renal blood volume control of blood pressure
has related synonym: renal regulation of blood volume
type: Class
subclass of: part-of-parent-50878
subclass of: renal system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
IAO_0000115: The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control.
has exact synonym: carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure
has related synonym: baroreceptor feedback control of blood pressure
has related synonym: baroreceptor pressure buffer system
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-3025

regulation of systemic arterial blood pressure by chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by chemoreceptor signalling
has related synonym: chemoreceptor control of blood pressure
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by ischemic conditions
IAO_0000115: The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.
has exact synonym: ischemic regulation of systemic arterial blood pressure
has related synonym: CNS ischemic response
has related synonym: ischemic control of blood pressure
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure

baroreceptor detection of arterial stretch
IAO_0000115: The series of events by which the change in diameter of an artery is detected and converted to a molecular signal.
type: Class
subclass of: part-of-parent-1978
subclass of: vascular process in circulatory system
subclass of: GO_0050982

baroreceptor response to decreased systemic arterial blood pressure
IAO_0000115: The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels.
type: Class
subclass of: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
subclass of: positive regulation of systemic arterial blood pressure

baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels.
type: Class
subclass of: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
subclass of: negative regulation of systemic arterial blood pressure

artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure.
has exact synonym: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
type: Class
subclass of: part-of-parent-1983
subclass of: GO_0042311

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.
has exact synonym: down regulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: down-regulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: downregulation of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: negative control of heart contraction rate in baroreceptor response to increased blood pressure
has exact synonym: negative regulation of heart contraction rate in baroreceptor response to increased blood pressure
has related synonym: inhibition of heart contraction rate in baroreceptor response to increased blood pressure
has related synonym: negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure
type: Class
subclass of: part-of-parent-1983
subclass of: GO_0010459

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
IAO_0000115: Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.
has exact synonym: decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure
has exact synonym: decreased strength of cardiac contraction during baroreceptor response to increased blood pressure
type: Class
subclass of: part-of-parent-1983
subclass of: GO_0045822

vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure.
type: Class
subclass of: part-of-parent-1982
subclass of: GO_0042310

positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
IAO_0000115: Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.
has exact synonym: positive control of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: up regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has exact synonym: upregulation of heart contraction rate in baroreceptor response to decreased blood pressure
has related synonym: activation of heart contraction rate in baroreceptor response to decreased blood pressure
has related synonym: positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure
has related synonym: stimulation of heart contraction rate in baroreceptor response to decreased blood pressure
type: Class
subclass of: part-of-parent-1982
subclass of: GO_0010460

positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure.
has related synonym: increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure
has related synonym: increased strength of cardiac contraction during baroreceptor response to decreased blood pressure
has related synonym: positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure
type: Class
subclass of: part-of-parent-1982
subclass of: GO_0045823

regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: blood pressure regulation by hormone
has exact synonym: hormonal regulation of blood pressure
has related synonym: hormonal control of blood pressure
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: GO_0050886

regulation of systemic arterial blood pressure by circulatory renin-angiotensin
IAO_0000115: The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
has exact synonym: circulatory renin-angiotensin blood pressure regulation
has exact synonym: circulatory renin-angiotensin regulation of blood pressure
has related synonym: circulatory renin-angiotensin control of blood pressure
has related synonym: control of blood pressure by circulatory renin-angiotensin
has related synonym: renin-angiotensin blood pressure control
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin

regulation of systemic arterial blood pressure by vasopressin
IAO_0000115: The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.
has exact synonym: blood pressure regulation by vasopressin
has related synonym: vasopressin control of blood pressure
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

regulation of systemic arterial blood pressure by norepinephrine-epinephrine
IAO_0000115: The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system.
has exact synonym: norepinephrine-epinephrine blood pressure regulation
has related synonym: noradrenaline-adrenaline regulation of blood pressure
has related synonym: norepinephrine-epinephrine blood pressure control
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
IAO_0000115: A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.
has exact synonym: noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure
has exact synonym: norepinephrine-epinephrine vasoconstriction during blood pressure regulation
has related synonym: norepinephrine-epinephrine vasoconstriction during blood pressure control
has related synonym: norepinephrine-epinephrine vasoconstriction during control of blood pressure
type: Class
subclass of: part-of-parent-3321
subclass of: GO_0042310

norepinephrine-epinephrine catabolic process in blood stream
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream.
has exact synonym: noradrenaline-adrenalin catabolic process in blood stream
type: Class
subclass of: part-of-parent-1993
subclass of: GO_0042419

positive regulation of heart rate by epinephrine-norepinephrine
IAO_0000115: The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.
has exact synonym: positive regulation of cardiac contraction rate by epinephrine-norepinephrine
has exact synonym: positive regulation of heart contraction rate by adrenaline-noradrenaline
has exact synonym: up regulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: up-regulation of heart contraction rate by epinephrine-norepinephrine
has exact synonym: upregulation of heart contraction rate by epinephrine-norepinephrine
has related synonym: activation of heart contraction rate by epinephrine-norepinephrine
has related synonym: increased chronotropy by epinephrine-norepinephrine
has related synonym: positive control of heart contraction rate by epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction rate by epinephrine-norepinephrine
has related synonym: stimulation of heart contraction rate by epinephrine-norepinephrine
type: Class
subclass of: part-of-parent-3321
subclass of: GO_0010460

positive regulation of the force of heart contraction by epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.
has exact synonym: increased force of heart contraction by adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine
has exact synonym: increased strength of cardiac contraction by epinephrine-norepinephrine
has related synonym: increased inotropy by epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by epinephrine-norepinephrine
type: Class
subclass of: part-of-parent-3321
subclass of: positive regulation of the force of heart contraction by chemical signal

angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
IAO_0000115: The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.
has exact synonym: angiotensin mediated vasoconstriction during blood pressure regulation
has exact synonym: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
has related synonym: angiotensin mediated vasoconstriction during blood pressure control
has related synonym: angiotensin mediated vasoconstriction during control of blood pressure
type: Class
subclass of: part-of-parent-2034
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310

renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
IAO_0000115: The physiological response of the kidneys to a decrease in blood flow.
has related synonym: renal response to blood flow during renin-angiotensin control of blood pressure
type: Class
subclass of: part-of-parent-1991
subclass of: renal system process involved in regulation of systemic arterial blood pressure

detection of renal blood flow
IAO_0000115: The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal.
type: Class
subclass of: part-of-parent-1999
subclass of: GO_0050982

renin secretion into blood stream
IAO_0000115: The regulated release of renin into the blood stream by juxtoglomerular cells.
has exact synonym: renin release into blood stream
type: Class
subclass of: part-of-parent-1999
subclass of: GO_0009306
subclass of: GO_0023061

regulation of angiotensin levels in blood
IAO_0000115: The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation.
has exact synonym: regulation of blood angiotensin level
has related synonym: control of angiotensin levels in blood
has related synonym: control of blood angiotensin level
type: Class
subclass of: part-of-parent-1991
subclass of: GO_0010817

angiotensin maturation
IAO_0000115: The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
has related synonym: angiotensin catabolic process in blood
replaces: GO_0002005
type: Class
subclass of: part-of-parent-2002
subclass of: GO_0016486

secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
IAO_0000115: The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure.
has related synonym: secretion of vasopressin during fast control of blood pressure
has related synonym: secretion of vasopressin during fast regulation of systemic arterial blood pressure
type: Class
subclass of: part-of-parent-1992
subclass of: GO_0030103

vasoconstriction by vasopressin involved in systemic arterial blood pressure control
IAO_0000115: The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream.
has exact synonym: vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control
type: Class
subclass of: part-of-parent-1992
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310

detection of hypoxic conditions in blood by chemoreceptor signaling
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of hypoxic conditions in blood by chemoreceptor signalling
type: Class
subclass of: part-of-parent-1979
subclass of: part-of-parent-70887
subclass of: GO_0009593

excitation of vasomotor center by chemoreceptor signaling
IAO_0000115: The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by chemoreceptor signalling
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1979
subclass of: part-of-parent-3084

morphogenesis of an epithelium
IAO_0000115: The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
has exact synonym: epithelium morphogenesis
type: Class
subclass of: part-of-parent-60429
subclass of: GO_0048729

excitation of vasomotor center by baroreceptor signaling
IAO_0000115: The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure.
has exact synonym: excitation of vasomotor center by baroreceptor signalling
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1982

morphogenesis of an epithelial sheet
IAO_0000115: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.
type: Class
subclass of: morphogenesis of an epithelium

vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
type: Class
subclass of: part-of-parent-1979
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310

detection of carbon dioxide by vasomotor center
IAO_0000115: The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system.
type: Class
subclass of: part-of-parent-1980
subclass of: detection of carbon dioxide

vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
IAO_0000115: The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.
type: Class
subclass of: part-of-parent-1980
subclass of: positive regulation of systemic arterial blood pressure
subclass of: GO_0042310

regulation of systemic arterial blood pressure by atrial baroreceptor feedback
IAO_0000115: A process that controls blood pressure by sensing the amount of stretch occurring in the atria.
has exact synonym: atrial baroreceptor regulation of systemic arterial blood pressure
has exact synonym: atrial low pressure baroreceptor regulation of blood pressure
has related synonym: atrial control of blood pressure
has related synonym: atrial reflex
type: Class
subclass of: part-of-parent-3025
subclass of: heart process

regulation of blood volume by renin-angiotensin
IAO_0000115: The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.
has exact synonym: renin-angiotensin regulation of blood volume
has related synonym: renin-angiotensin control of body fluid levels
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin

regulation of blood volume by renal aldosterone
IAO_0000115: The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.
has exact synonym: aldosterone mediated regulation of blood volume
has exact synonym: renal regulation of blood volume by aldosterone
has related synonym: aldosterone mediated control of body fluids
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: regulation of systemic arterial blood pressure by hormone
subclass of: positive regulation of systemic arterial blood pressure

renin-angiotensin regulation of aldosterone production
IAO_0000115: The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
has related synonym: renin-angiotensin control of aldosterone production
type: Class
subclass of: part-of-parent-2016
subclass of: renal system process involved in regulation of systemic arterial blood pressure
subclass of: GO_2000858

regulation of renal output by angiotensin
IAO_0000115: The process in which angiotensin directly modulates the rate of urine output by the kidney.
has exact synonym: angiotensin mediated regulation of renal output
has exact synonym: angiotensin-mediated regulation of renal output
has related synonym: angiotensin mediated control of renal output
type: Class
subclass of: regulation of blood volume by renin-angiotensin

protease binding
IAO_0000115: Interacting selectively and non-covalently with any protease or peptidase.
type: Class
subclass of: GO_0019899

response to dietary excess
IAO_0000115: The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
type: Class
subclass of: GO_0031667
subclass of: GO_0032501

detection of dietary excess
IAO_0000115: The neurological process in which the brain senses excessive caloric intake.
type: Class
subclass of: part-of-parent-2021
subclass of: GO_0050877

reduction of food intake in response to dietary excess
IAO_0000115: An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients.
type: Class
subclass of: part-of-parent-2021
subclass of: GO_0042755

diet induced thermogenesis
IAO_0000115: The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
type: Class
subclass of: part-of-parent-2021
subclass of: GO_1990845

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
IAO_0000115: A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.
has exact synonym: noradrenaline-adrenaline vasodilation involved in regulation of blood pressure
has exact synonym: norepinephrine-epinephrine vasodilation during blood pressure regulation
has exact synonym: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
type: Class
subclass of: part-of-parent-1993
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311

regulation of the force of heart contraction
IAO_0000115: Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
has exact synonym: cardiac inotropy
has exact synonym: heart inotropy
type: Class
subclass of: GO_0008016
subclass of: GO_0065008

regulation of heart rate
IAO_0000115: Any process that modulates the frequency or rate of heart contraction.
has exact synonym: cardiac chronotropy
has exact synonym: regulation of heart contraction rate
has exact synonym: regulation of rate of heart contraction
type: Class
subclass of: GO_0008016
subclass of: GO_0065008

regulation of sodium ion transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has exact synonym: regulation of Na+ transport
has exact synonym: regulation of sodium transport
type: Class
subclass of: GO_0010959

desensitization of G protein-coupled receptor signaling pathway
IAO_0000115: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
has exact synonym: desensitisation of G-protein coupled receptor protein signalling pathway
has exact synonym: desensitization of G-protein coupled receptor protein signaling pathway
type: Class
subclass of: GO_0022401
subclass of: GO_0045744

inhibitory G protein-coupled receptor phosphorylation
IAO_0000115: The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site.
has exact synonym: inhibitory G-protein coupled receptor phosphorylation
type: Class
subclass of: part-of-parent-2029
subclass of: GO_0006468

G protein-coupled receptor internalization
IAO_0000115: The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.
has exact synonym: G-protein coupled receptor internalization
type: Class
subclass of: part-of-parent-2029
subclass of: GO_0031623

desensitization of G protein-coupled receptor signaling pathway by arrestin
IAO_0000115: The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.
has exact synonym: arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway
has exact synonym: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway
has exact synonym: arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway
has exact synonym: desensitization of G-protein coupled receptor protein signaling pathway by arrestin
type: Class
subclass of: desensitization of G protein-coupled receptor signaling pathway
subclass of: GO_0032091

angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
IAO_0000115: The process that increases the diameter of a blood vessel via the renin-angiotensin system.
has exact synonym: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
type: Class
subclass of: part-of-parent-2034
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311

regulation of blood vessel diameter by renin-angiotensin
IAO_0000115: The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.
has related synonym: regulation of blood vessel size by renin-angiotensin
has related synonym: renin-angiotensin regulation of blood vessel size
type: Class
subclass of: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin
subclass of: GO_0097746

brain renin-angiotensin system
IAO_0000115: The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: regulation of blood volume by renin-angiotensin

regulation of L-glutamate import across plasma membrane
IAO_0000115: Any process that modulates the frequency, rate or extent of L-glutamate import into a cell.
has exact synonym: regulation of L-glutamate uptake
has related synonym: regulation of L-glutamate import
has related synonym: regulation of L-glutamate transport
replaces: GO_1900920
type: Class
subclass of: GO_0010958

negative regulation of L-glutamate import across plasma membrane
IAO_0000115: Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell.
has exact synonym: down regulation of L-glutamate import
has exact synonym: down-regulation of L-glutamate import
has exact synonym: downregulation of L-glutamate import
has related synonym: down regulation of L-glutamate transport
has related synonym: down regulation of L-glutamate uptake
has related synonym: down-regulation of L-glutamate transport
has related synonym: down-regulation of L-glutamate uptake
has related synonym: downregulation of L-glutamate transport
has related synonym: downregulation of L-glutamate uptake
has related synonym: inhibition of L-glutamate import
has related synonym: inhibition of L-glutamate transport
has related synonym: inhibition of L-glutamate uptake
has related synonym: negative regulation of L-glutamate import
has related synonym: negative regulation of L-glutamate transport
has related synonym: negative regulation of L-glutamate uptake
has related synonym: regulation of L-glutamate import
replaces: GO_1900921
type: Class
subclass of: regulation of L-glutamate import across plasma membrane
subclass of: GO_0051956
subclass of: GO_1903960

positive regulation of L-glutamate import across plasma membrane
IAO_0000115: Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell.
has exact synonym: up regulation of L-glutamate import
has exact synonym: up-regulation of L-glutamate import
has exact synonym: up-regulation of L-glutamate transport
has exact synonym: upregulation of L-glutamate import
has related synonym: activation of L-glutamate import
has related synonym: activation of L-glutamate transport
has related synonym: activation of L-glutamate uptake
has related synonym: positive regulation of L-glutamate import
has related synonym: positive regulation of L-glutamate transport
has related synonym: positive regulation of L-glutamate uptake
has related synonym: stimulation of L-glutamate transport
has related synonym: up regulation of L-glutamate transport
has related synonym: up regulation of L-glutamate uptake
has related synonym: up-regulation of L-glutamate uptake
has related synonym: upregulation of L-glutamate transport
has related synonym: upregulation of L-glutamate uptake
replaces: GO_1900922
type: Class
subclass of: regulation of L-glutamate import across plasma membrane
subclass of: GO_0051957
subclass of: GO_1903961

p53 binding
IAO_0000115: Interacting selectively and non-covalently with one of the p53 family of proteins.
type: Class
subclass of: GO_0005515

sprouting angiogenesis
IAO_0000115: The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
type: Class
subclass of: angiogenesis

intussusceptive angiogenesis
IAO_0000115: The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.
type: Class
subclass of: angiogenesis

cell migration involved in sprouting angiogenesis
IAO_0000115: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
type: Class
subclass of: part-of-parent-2040
subclass of: GO_0043534

blood vessel endothelial cell proliferation involved in sprouting angiogenesis
IAO_0000115: The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
has related synonym: blood vessel endothelial cell proliferation during sprouting angiogenesis
type: Class
subclass of: endothelial cell proliferation
subclass of: part-of-parent-2040

blood vessel endothelial cell migration involved in intussusceptive angiogenesis
IAO_0000115: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis.
type: Class
subclass of: part-of-parent-2041
subclass of: GO_0043534

regulation of cell adhesion involved in intussusceptive angiogenesis
IAO_0000115: The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis.
type: Class
subclass of: part-of-parent-2041
subclass of: GO_0030155

opsin binding
IAO_0000115: Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.
has related synonym: metarhodopsin binding
replaces: GO_0016030
type: Class
subclass of: GO_0005515

phenazine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
has related synonym: acridizine biosynthesis
has related synonym: acridizine biosynthetic process
has related synonym: azophenylene biosynthesis
has related synonym: azophenylene biosynthetic process
has related synonym: dibenzo-p-diazine biosynthesis
has related synonym: dibenzo-p-diazine biosynthetic process
has related synonym: dibenzopyrazine biosynthesis
has related synonym: dibenzopyrazine biosynthetic process
type: Class
subclass of: GO_0017000
subclass of: GO_0018130
subclass of: GO_0019438
subclass of: GO_0044271
subclass of: GO_1901362
subclass of: GO_1901566

pyoverdine metabolic process
IAO_0000115: The chemical reactions and pathways involving the siderochrome pyoverdine.
has exact synonym: pyoverdine metabolism
type: Class
subclass of: GO_0009237

pyoverdine biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
type: Class
subclass of: pyoverdine metabolic process
subclass of: GO_0019290

pyoverdine catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine.
type: Class
subclass of: pyoverdine metabolic process
subclass of: GO_0046215

osteoblast fate commitment
IAO_0000115: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
type: Class
subclass of: part-of-parent-1649
subclass of: GO_0045165

positive regulation of neuroblast proliferation
IAO_0000115: Any process that activates or increases the rate of neuroblast proliferation.
has exact synonym: up regulation of neuroblast proliferation
has exact synonym: up-regulation of neuroblast proliferation
has exact synonym: upregulation of neuroblast proliferation
has related synonym: activation of neuroblast proliferation
has related synonym: stimulation of neuroblast proliferation
type: Class
subclass of: GO_0050769
subclass of: GO_1902692
subclass of: GO_2000179
subclass of: GO_2000648

positive regulation of mesenchymal cell proliferation
IAO_0000115: The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
has exact synonym: up regulation of mesenchymal cell proliferation
has exact synonym: up-regulation of mesenchymal cell proliferation
has exact synonym: upregulation of mesenchymal cell proliferation
has related synonym: activation of mesenchymal cell proliferation
has related synonym: stimulation of mesenchymal cell proliferation
type: Class
subclass of: GO_0008284
subclass of: GO_0010464

nucleobase binding
IAO_0000115: Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.
type: Class
subclass of: GO_0036094
subclass of: GO_0097159
subclass of: GO_1901363

adenine binding
IAO_0000115: Interacting selectively and non-covalently with adenine, a purine base.
has exact synonym: 6-aminopurine binding
type: Class
subclass of: purine nucleobase binding

cytosine binding
IAO_0000115: Interacting selectively and non-covalently with cytosine.
type: Class
subclass of: pyrimidine nucleobase binding

guanine binding
IAO_0000115: Interacting selectively and non-covalently with guanine.
type: Class
subclass of: purine nucleobase binding

uracil binding
IAO_0000115: Interacting selectively and non-covalently with uracil.
type: Class
subclass of: pyrimidine nucleobase binding

thymine binding
IAO_0000115: Interacting selectively and non-covalently with thymine.
type: Class
subclass of: pyrimidine nucleobase binding

purine nucleobase binding
IAO_0000115: Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.
has exact synonym: purine base binding
has related synonym: purine binding
type: Class
subclass of: nucleobase binding

pyrimidine nucleobase binding
IAO_0000115: Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton.
has exact synonym: pyrimidine base binding
has related synonym: 1,3-diazine binding
has related synonym: pyrimidine binding
type: Class
subclass of: nucleobase binding

chondrocyte differentiation
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
type: Class
subclass of: part-of-parent-51216
subclass of: GO_0030154

chondrocyte development
IAO_0000115: The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
type: Class
subclass of: part-of-parent-2062
subclass of: GO_0048468

epithelial cell development
IAO_0000115: The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
type: Class
subclass of: part-of-parent-30855
subclass of: GO_0048468

columnar/cuboidal epithelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
type: Class
subclass of: GO_0030855

columnar/cuboidal epithelial cell development
IAO_0000115: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
type: Class
subclass of: epithelial cell development
subclass of: part-of-parent-2065

glandular epithelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
type: Class
subclass of: columnar/cuboidal epithelial cell differentiation

glandular epithelial cell development
IAO_0000115: The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
type: Class
subclass of: columnar/cuboidal epithelial cell development
subclass of: part-of-parent-2067

columnar/cuboidal epithelial cell maturation
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
type: Class
subclass of: part-of-parent-2066
subclass of: epithelial cell maturation

epithelial cell maturation
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
type: Class
subclass of: part-of-parent-2064
subclass of: GO_0048469

glandular epithelial cell maturation
IAO_0000115: The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
type: Class
subclass of: columnar/cuboidal epithelial cell maturation
subclass of: part-of-parent-2068

optic cup morphogenesis involved in camera-type eye development
IAO_0000115: The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.
has exact synonym: optic cup morphogenesis involved in camera-style eye development
type: Class
subclass of: part-of-parent-60900
subclass of: GO_0016331

extraocular skeletal muscle development
IAO_0000115: The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.
type: Class
subclass of: part-of-parent-43010
subclass of: GO_0007519
subclass of: GO_0060538

somitomeric trunk muscle development
IAO_0000115: The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.
type: Class
subclass of: GO_0060538

osteoblast development
IAO_0000115: The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
type: Class
subclass of: part-of-parent-1649
subclass of: GO_0048468

acrosome matrix dispersal
IAO_0000115: The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane.
type: Class
subclass of: part-of-parent-7340
subclass of: GO_0022414
subclass of: GO_0051603

membrane fusion involved in acrosome reaction
IAO_0000115: The fusion of the plasma membrane of the sperm with the outer acrosomal membrane.
has exact synonym: membrane fusion involved in the acrosomal reaction
type: Class
subclass of: part-of-parent-7340
subclass of: GO_0022412
subclass of: GO_0061025

inner acrosomal membrane
IAO_0000115: The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.
type: Class
subclass of: part-of-parent-2080
subclass of: GO_0098589

acrosomal membrane
IAO_0000115: The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.
type: Class
subclass of: part-of-parent-1669
subclass of: GO_0030667

outer acrosomal membrane
IAO_0000115: The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.
type: Class
subclass of: part-of-parent-2080
subclass of: GO_0098589

regulation of oxidative phosphorylation
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
has exact synonym: OXPHOS
type: Class
subclass of: GO_0042325
subclass of: GO_0043467
subclass of: GO_1903578

4-hydroxybenzoate decaprenyltransferase activity
IAO_0000115: Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.
type: Class
subclass of: polyprenyltransferase activity

protein depalmitoylation
IAO_0000115: The removal of palymitoyl groups from a lipoprotein.
type: Class
subclass of: GO_0035601
subclass of: GO_0042159
subclass of: GO_0098734

inhibition of neuroepithelial cell differentiation
IAO_0000115: Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.
has related synonym: negative regulation of neural plate formation
has related synonym: repression of premature neural plate formation
type: Class
subclass of: GO_0022603
subclass of: GO_0030857
subclass of: GO_0045995
subclass of: GO_0048505

diaphragm contraction
IAO_0000115: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.
type: Class
subclass of: involuntary skeletal muscle contraction
subclass of: respiratory system process

regulation of respiratory gaseous exchange by nervous system process
IAO_0000115: A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
has exact synonym: neurological control of breathing
has exact synonym: regulation of respiratory gaseous exchange by neurological system process
type: Class
subclass of: GO_0044065
subclass of: GO_0050877

lens development in camera-type eye
IAO_0000115: The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
has exact synonym: lens development
has exact synonym: lens development in camera-style eye
type: Class
subclass of: part-of-parent-43010
subclass of: GO_0048856

lens morphogenesis in camera-type eye
IAO_0000115: The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
has exact synonym: lens morphogenesis
has exact synonym: lens morphogenesis in camera-style eye
type: Class
subclass of: part-of-parent-2088
subclass of: part-of-parent-48593
subclass of: GO_0009653

regulation of receptor internalization
IAO_0000115: Any process that modulates the frequency, rate or extent of receptor internalization.
type: Class
subclass of: GO_0031323
subclass of: GO_0048259
subclass of: GO_0060255

negative regulation of receptor internalization
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
has exact synonym: down regulation of receptor internalization
has exact synonym: down-regulation of receptor internalization
has exact synonym: downregulation of receptor internalization
has related synonym: inhibition of receptor internalization
type: Class
subclass of: regulation of receptor internalization
subclass of: GO_0010605
subclass of: GO_0031324
subclass of: GO_0048261

positive regulation of receptor internalization
IAO_0000115: Any process that activates or increases the frequency, rate or extent of receptor internalization.
has exact synonym: up regulation of receptor internalization
has exact synonym: up-regulation of receptor internalization
has exact synonym: upregulation of receptor internalization
has related synonym: activation of receptor internalization
has related synonym: stimulation of receptor internalization
type: Class
subclass of: regulation of receptor internalization
subclass of: GO_0010604
subclass of: GO_0031325
subclass of: GO_0048260

auditory receptor cell morphogenesis
IAO_0000115: Any process that alters the size or shape of an auditory receptor cell.
has related synonym: hair cell morphogenesis
type: Class
subclass of: part-of-parent-42472
subclass of: part-of-parent-60117
subclass of: GO_0048598
subclass of: GO_0048667

polyprenyltransferase activity
IAO_0000115: Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).
type: Class
subclass of: prenyltransferase activity

caveolar macromolecular signaling complex
IAO_0000115: A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
has exact synonym: caveolar macromolecular signalling complex
type: Class
subclass of: part-of-parent-5901
subclass of: GO_0098797

polkadots
IAO_0000115: A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.
type: Class
subclass of: part-of-parent-5737
subclass of: GO_0032991

tRNA wobble base modification
IAO_0000115: The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.
type: Class
subclass of: GO_0006400

tRNA wobble uridine modification
IAO_0000115: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.
type: Class
subclass of: tRNA wobble base modification

tRNA wobble guanine modification
IAO_0000115: The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified.
type: Class
subclass of: tRNA wobble base modification

tRNA wobble adenosine to inosine editing
IAO_0000115: The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.
type: Class
subclass of: tRNA wobble base modification
subclass of: GO_0006382

tRNA wobble cytosine modification
IAO_0000115: The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.
type: Class
subclass of: tRNA wobble base modification

podosome
IAO_0000115: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
type: Class
subclass of: part-of-parent-15629
subclass of: GO_0043232

endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage involved in rRNA processing

endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
IAO_0000115: Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.
type: Class
subclass of: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
IAO_0000115: The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end.
type: Class
subclass of: maturation of 5S rRNA
subclass of: GO_0031125

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
IAO_0000115: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: maturation of LSU-rRNA

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
IAO_0000115: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.
type: Class
subclass of: GO_0030490

cotranscriptional mitochondrial rRNA nucleotide insertion
IAO_0000115: The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis.
type: Class
subclass of: rRNA modification
subclass of: GO_0070705

BRCA2-BRAF35 complex
IAO_0000115: A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.
type: Class
subclass of: part-of-parent-5634
subclass of: GO_0032991

interleukin-33 receptor binding
IAO_0000115: Interacting selectively and non-covalently with the interleukin-33 receptor.
has related synonym: IL-33
has related synonym: interleukin-33 receptor ligand
type: Class
subclass of: GO_0005126

interleukin-33 binding
IAO_0000115: Interacting selectively and non-covalently with interleukin-33.
has exact synonym: IL-33 binding
type: Class
subclass of: GO_0019955

interleukin-33 receptor activity
IAO_0000115: Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: IL-33 receptor activity
has exact synonym: IL-33R
type: Class
subclass of: part-of-parent-38172
subclass of: GO_0004896

store-operated calcium entry
IAO_0000115: A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
has exact synonym: SOCE
has exact synonym: capacitative calcium entry
has exact synonym: store-operated calcium import
has related synonym: calcium ion import
type: Class
subclass of: GO_0006816

semaphorin receptor complex
IAO_0000115: A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
has exact synonym: plexin-neurophilin complex
type: Class
subclass of: GO_0043235

amphibian larval development
IAO_0000115: The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form.
type: Class
subclass of: larval development

aggressive behavior
IAO_0000115: A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.
has exact synonym: aggression
type: Class
subclass of: GO_0007610

nematode larval development
IAO_0000115: The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
type: Class
subclass of: larval development

obsolete predatory behavior
IAO_0000115: OBSOLETE. Aggressive behavior involving attack on prey by a predator.
type: Class
subclass of: ObsoleteClass

inter-male aggressive behavior
IAO_0000115: Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
has exact synonym: inter-male aggression
type: Class
subclass of: aggressive behavior

fear-induced aggressive behavior
IAO_0000115: Aggressive behavior associated with attempts to flee from a threat.
has exact synonym: fear-induced aggression
type: Class
subclass of: aggressive behavior

irritable aggressive behavior
IAO_0000115: Aggressive behavior induced by frustration and directed against an available target.
has exact synonym: irritable aggression
type: Class
subclass of: aggressive behavior

territorial aggressive behavior
IAO_0000115: Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.
has exact synonym: territorial aggression
type: Class
subclass of: aggressive behavior

maternal aggressive behavior
IAO_0000115: Aggressive behavior of a female to protect her offspring from a threat.
has exact synonym: maternal aggression
type: Class
subclass of: aggressive behavior

instrumental aggressive behavior
IAO_0000115: Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation.
has exact synonym: instrumental aggression
type: Class
subclass of: aggressive behavior

tRNA wobble base cytosine methylation
IAO_0000115: The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.
has exact synonym: wobble position m5C biosynthesis
type: Class
subclass of: tRNA wobble cytosine modification
subclass of: tRNA C5-cytosine methylation

tRNA nucleoside ribose methylation
IAO_0000115: The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position.
type: Class
subclass of: GO_0030488

wobble position guanine ribose methylation
IAO_0000115: The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
type: Class
subclass of: wobble position ribose methylation
subclass of: tRNA guanine ribose methylation

wobble position ribose methylation
IAO_0000115: The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position.
type: Class
subclass of: tRNA nucleoside ribose methylation

wobble position cytosine ribose methylation
IAO_0000115: The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
type: Class
subclass of: wobble position ribose methylation

wobble position uridine ribose methylation
IAO_0000115: The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
type: Class
subclass of: wobble position ribose methylation

polycystin complex
IAO_0000115: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.
type: Class
subclass of: GO_0032991

UTP binding
IAO_0000115: Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate.
type: Class
subclass of: GO_0032557
subclass of: GO_0043168

CTP binding
IAO_0000115: Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate.
type: Class
subclass of: GO_0032557
subclass of: GO_0043168

tRNA wobble base lysidine biosynthesis
IAO_0000115: The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.
type: Class
subclass of: tRNA wobble cytosine modification

retinoic acid biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
has exact synonym: retinoic acid anabolic process
type: Class
subclass of: GO_0016102
subclass of: GO_0042573
subclass of: GO_0072330

stereocilia coupling link
IAO_0000115: A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.
type: Class
subclass of: part-of-parent-32421
subclass of: GO_0110165

stereocilia tip link
IAO_0000115: A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia.
type: Class
subclass of: stereocilia coupling link

stereocilia ankle link
IAO_0000115: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.
type: Class
subclass of: stereocilia coupling link

stereocilia ankle link complex
IAO_0000115: A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.
type: Class
subclass of: part-of-parent-2141
subclass of: GO_0032991

tRNA wobble position uridine thiolation
IAO_0000115: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
has exact synonym: tRNA wobble uridine thiolation
has exact synonym: wobble position s2U biosynthesis
type: Class
subclass of: tRNA wobble uridine modification
subclass of: GO_0034227

cytosolic tRNA wobble base thiouridylase complex
IAO_0000115: A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets.
has related synonym: Cut1-Cut2 complex
has related synonym: tRNA thiouridylase
type: Class
subclass of: part-of-parent-5829
subclass of: GO_0032991

4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
IAO_0000115: Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+).
has exact synonym: HMP-PP diphosphatase
has exact synonym: HMP-PP pyrophosphatase
type: Class
subclass of: GO_0016462

obsolete steroid hormone receptor import into nucleus
IAO_0000115: OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus.
type: Class
subclass of: ObsoleteClass

obsolete glucocorticoid receptor import into nucleus
IAO_0000115: OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus.
type: Class
subclass of: ObsoleteClass

hypochlorous acid metabolic process
IAO_0000115: The chemical reactions and pathways involving hypochlorous acid.
has exact synonym: HClO metabolic process
has exact synonym: HOCl metabolic process
has exact synonym: hypochlorous acid metabolism
has related synonym: hypochlorite metabolic process
type: Class
subclass of: GO_0043436
subclass of: GO_0072593

hypochlorous acid biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of hypochlorous acid.
has exact synonym: HClO biosynthetic process
has exact synonym: HOCl biosynthetic process
has exact synonym: hypochlorous acid biosynthesis
has related synonym: hypochlorite biosynthetic process
type: Class
subclass of: hypochlorous acid metabolic process
subclass of: GO_0044283
subclass of: GO_1903409

hypochlorous acid catabolic process
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of hypochlorous acid.
has exact synonym: HClO catabolic process
has exact synonym: HOCl catabolic process
has exact synonym: hypochlorous acid catabolism
has related synonym: hypochlorite catabolic process
type: Class
subclass of: hypochlorous acid metabolic process
subclass of: GO_0044282

G-quadruplex RNA binding
IAO_0000115: Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
has exact synonym: G quadruplex binding
has exact synonym: G quartet RNA binding
has related synonym: G quartet binding
has related synonym: G-quartet binding
type: Class
subclass of: RNA binding

bile acid conjugation
IAO_0000115: The process in which bile acids are covalently linked to taurine or glycine.
type: Class
subclass of: GO_0008206

steroid receptor RNA activator RNA binding
IAO_0000115: Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
has exact synonym: SRA binding
type: Class
subclass of: single-stranded RNA binding

thyroid hormone mediated signaling pathway
IAO_0000115: A series of molecular signals mediated by the detection of a thyroid hormone.
has exact synonym: thyroid hormone mediated signalling pathway
type: Class
subclass of: GO_0009755
subclass of: GO_0030522

regulation of thyroid hormone mediated signaling pathway
IAO_0000115: Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
has exact synonym: regulation of thyroid hormone mediated signalling pathway
type: Class
subclass of: GO_0009966

negative regulation of thyroid hormone mediated signaling pathway
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway.
has exact synonym: negative regulation of thyroid hormone mediated signalling pathway
type: Class
subclass of: regulation of thyroid hormone mediated signaling pathway
subclass of: GO_0009968

positive regulation of thyroid hormone mediated signaling pathway
IAO_0000115: Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway.
has exact synonym: positive regulation of thyroid hormone mediated signalling pathway
type: Class
subclass of: regulation of thyroid hormone mediated signaling pathway
subclass of: GO_0009967

osteoclast proliferation
IAO_0000115: The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.
type: Class
subclass of: GO_0070661

desmosome assembly
IAO_0000115: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
type: Class
subclass of: desmosome organization
subclass of: GO_0007043

desmosome maintenance
IAO_0000115: The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
type: Class
subclass of: desmosome organization
subclass of: GO_0045217

aminoacyl-tRNA editing activity
IAO_0000115: The hydrolysis of an incorrectly aminoacylated tRNA.
has related synonym: amino acid proofreading activity
has related synonym: aminoacyl-tRNA hydrolysis activity
type: Class
subclass of: part-of-parent-106074
subclass of: GO_0052689
subclass of: GO_0140101

dystroglycan binding
IAO_0000115: Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
has related synonym: alpha-dystroglycan binding
has related synonym: beta-dystroglycan binding
replaces: GO_0002163
replaces: GO_0002166
type: Class
subclass of: GO_0005515

larval development
IAO_0000115: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.
type: Class
subclass of: GO_0007275
subclass of: GO_0009791

instar larval or pupal development
IAO_0000115: The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.
type: Class
subclass of: GO_0007275
subclass of: GO_0009791

VRK3/VHR/ERK complex
IAO_0000115: A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.
type: Class
subclass of: GO_0032991

instar larval development
IAO_0000115: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
type: Class
subclass of: larval development
subclass of: instar larval or pupal development

3-methylcrotonyl-CoA carboxylase complex, mitochondrial
IAO_0000115: A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
has exact synonym: mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme
has exact synonym: mitochondrial MCCC complex
has exact synonym: mitochondrial methylcrotonoyl-CoA carboxylase complex
type: Class
subclass of: part-of-parent-5739
subclass of: GO_0098798
subclass of: GO_1905202

high-affinity IgA receptor activity
IAO_0000115: Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: high affinity IgA receptor activity
type: Class
subclass of: GO_0019766

low-affinity IgA receptor activity
IAO_0000115: Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: low affinity IgA receptor activity
type: Class
subclass of: GO_0019766

high-affinity IgM receptor activity
IAO_0000115: Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: high affinity IgM receptor activity
type: Class
subclass of: IgM receptor activity

low-affinity IgM receptor activity
IAO_0000115: Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
has exact synonym: low affinity IgM receptor activity
type: Class
subclass of: IgM receptor activity

mammary stem cell proliferation
IAO_0000115: The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ.
type: Class
subclass of: part-of-parent-30879
subclass of: GO_0008283

protein localization to paranode region of axon
IAO_0000115: A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.
has exact synonym: protein localisation to paranode region of axon
type: Class
subclass of: GO_0034613
subclass of: GO_0099612

male germ cell proliferation
IAO_0000115: The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.
type: Class
subclass of: GO_0036093

manchette
IAO_0000115: A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
type: Class
subclass of: part-of-parent-15630
subclass of: GO_0110165

palmitoyltransferase complex
IAO_0000115: A protein complex with palmitoyltransferase activity.
type: Class
subclass of: GO_1990234

homodimeric serine palmitoyltransferase complex
IAO_0000115: A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.
type: Class
subclass of: GO_0017059

5-lipoxygenase complex
IAO_0000115: An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.
type: Class
subclass of: part-of-parent-31965
subclass of: GO_0098796
subclass of: GO_1990204

cytoplasmic translation
IAO_0000115: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
type: Class
subclass of: GO_0006412

cytoplasmic translational elongation
IAO_0000115: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.
type: Class
subclass of: part-of-parent-2181
subclass of: GO_0006414

cytoplasmic translational initiation
IAO_0000115: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
type: Class
subclass of: part-of-parent-2181
subclass of: GO_0006413

cytoplasmic translational termination
IAO_0000115: The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
type: Class
subclass of: part-of-parent-2181
subclass of: GO_0006415

creatine kinase complex
IAO_0000115: A protein complex having creatine kinase activity.
type: Class
subclass of: GO_0061695

cytosolic creatine kinase complex
IAO_0000115: A dimeric protein complex having creatine kinase activity.
type: Class
subclass of: creatine kinase complex
subclass of: part-of-parent-5829

mitochondrial creatine kinase complex
IAO_0000115: An octomeric protein complex having creatine kinase activity.
type: Class
subclass of: creatine kinase complex
subclass of: part-of-parent-5739
subclass of: GO_0098798

translation reinitiation
IAO_0000115: A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
type: Class
subclass of: cytoplasmic translational initiation

ribose phosphate diphosphokinase complex
IAO_0000115: A protein complex having ribose phosphate diphosphokinase activity.
has exact synonym: PRPP synthetase complex
has exact synonym: phosphoribosylpyrophosphate synthetase complex
type: Class
subclass of: GO_0061695

cap-independent translational initiation
IAO_0000115: The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation.
type: Class
subclass of: cytoplasmic translational initiation

cap-dependent translational initiation
IAO_0000115: The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
type: Class
subclass of: cytoplasmic translational initiation

IRES-dependent translational initiation of linear mRNA
IAO_0000115: The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.
type: Class
subclass of: GO_0110017

MAML1-RBP-Jkappa- ICN1 complex
IAO_0000115: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
has exact synonym: MAML1-CSL-ICN1
has exact synonym: MAML1-CSL-Notch1 complex
has exact synonym: MAML1-RBP-Jkappa-Notch1 complex
type: Class
subclass of: GO_0032991

hepatocyte cell migration
IAO_0000115: The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.
type: Class
subclass of: GO_0016477

2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
IAO_0000115: The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs.
type: Class
subclass of: GO_0006400

Ser-tRNA(Ala) hydrolase activity
IAO_0000115: Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).
type: Class
subclass of: aminoacyl-tRNA editing activity

xanthine dehydrogenase complex
IAO_0000115: A homodimeric protein complex having xanthine dehydrogenase activity.
type: Class
subclass of: GO_1990204

obsolete S/G2 transition of mitotic cell cycle
IAO_0000115: OBSOLETE. The transition from a cell in the S phase to the G2 phase.
type: Class
subclass of: ObsoleteClass

zona pellucida receptor complex
IAO_0000115: A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
has related synonym: sperm protein complex I
type: Class
subclass of: GO_0032991

somatic diversification of immune receptors
IAO_0000115: The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
type: Class
subclass of: part-of-parent-2520
subclass of: immune system process

somatic diversification of DSCAM-based immune receptors
IAO_0000115: The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects.
type: Class
subclass of: somatic diversification of immune receptors

somatic diversification of variable lymphocyte receptors of jawless fish
IAO_0000115: The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish.
type: Class
subclass of: somatic diversification of immune receptors

proteolysis by cytosolic proteases associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation.
type: Class
subclass of: proteolysis associated with antigen processing and presentation

somatic recombination of immunoglobulin genes involved in immune response
IAO_0000115: The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.
has related synonym: somatic recombination of antibody genes during immune response
has related synonym: somatic recombination of immunoglobulin genes during immune response
type: Class
subclass of: somatic diversification of immunoglobulins involved in immune response
subclass of: GO_0016447

somatic hypermutation of immunoglobulin genes involved in immune response
IAO_0000115: Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response.
has related synonym: somatic hypermutation of antibody genes during immune response
has related synonym: somatic hypermutation of immunoglobulin genes during immune response
type: Class
subclass of: part-of-parent-2344
subclass of: somatic diversification of immunoglobulins involved in immune response
subclass of: GO_0016446

gene conversion of immunoglobulin genes
IAO_0000115: The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion.
has exact synonym: gene conversion of antibody genes
type: Class
subclass of: somatic diversification of immune receptors via gene conversion
subclass of: GO_0016445
subclass of: GO_0035822

gene conversion of immunoglobulin genes involved in immune response
IAO_0000115: The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response.
has related synonym: gene conversion of antibody genes during immune response
has related synonym: gene conversion of immunoglobulin genes during immune response
type: Class
subclass of: gene conversion of immunoglobulin genes
subclass of: somatic diversification of immunoglobulins involved in immune response

somatic diversification of immunoglobulins involved in immune response
IAO_0000115: The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.
has related synonym: somatic diversification of antibodies during immune response
has related synonym: somatic diversification of immunoglobulins during immune response
type: Class
subclass of: part-of-parent-2381
subclass of: GO_0016445

behavioral defense response
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat to that organism.
has exact synonym: behavioural defense response
type: Class
subclass of: GO_0006952
subclass of: GO_0007610

behavioral response to wounding
IAO_0000115: A behavioral response resulting from wounding.
has exact synonym: behavioural response to wounding
type: Class
subclass of: GO_0007610
subclass of: GO_0009611

behavioral defense response to insect
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism.
has exact synonym: behavioural defense response to insect
type: Class
subclass of: behavioral defense response
subclass of: defense response to insect

behavioral defense response to nematode
IAO_0000115: A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism.
has exact synonym: behavioural defense response to nematode
type: Class
subclass of: behavioral defense response
subclass of: defense response to nematode

defense response to insect
IAO_0000115: A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.
has exact synonym: physiological defense response to insect
replaces: GO_0002214
type: Class
subclass of: GO_0098542

defense response to nematode
IAO_0000115: A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
has exact synonym: physiological defense response to nematode
replaces: GO_0002216
type: Class
subclass of: GO_0098542

activation of innate immune response
IAO_0000115: Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
replaces: GO_0002219
type: Class
subclass of: activation of immune response
subclass of: GO_0045089

innate immune response activating cell surface receptor signaling pathway
IAO_0000115: Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor.
has exact synonym: activation of innate immune response by cell surface receptor signaling pathway
has exact synonym: innate immune response activating cell surface receptor signalling pathway
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway
subclass of: innate immune response-activating signal transduction

pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
has exact synonym: PAMP receptor signaling pathway
has exact synonym: PRR signaling pathway
has exact synonym: pathogen receptor signaling pathway
has exact synonym: pathogen receptor signalling pathway
type: Class
subclass of: GO_0007165

stimulatory killer cell immunoglobulin-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation.
has exact synonym: stimulatory KIR signaling pathway
has exact synonym: stimulatory killer cell immunoglobulin-like receptor signalling pathway
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway

stimulatory C-type lectin receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
has exact synonym: stimulatory C-type lectin receptor signalling pathway
has related synonym: stimulatory Ly49 family receptor signaling pathway
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway

toll-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has exact synonym: TLR signaling pathway
has exact synonym: toll-like receptor signalling pathway
type: Class
subclass of: pattern recognition receptor signaling pathway

positive regulation of antimicrobial peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
has exact synonym: antimicrobial peptide induction
has exact synonym: up regulation of antimicrobial peptide production
has exact synonym: up-regulation of antimicrobial peptide production
has exact synonym: upregulation of antimicrobial peptide production
has related synonym: activation of antimicrobial peptide production
has related synonym: stimulation of antimicrobial peptide production
type: Class
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: positive regulation of antimicrobial humoral response
subclass of: regulation of antimicrobial peptide production

innate immune response in mucosa
IAO_0000115: Any process of the innate immune response that takes place in the mucosal tissues.
type: Class
subclass of: mucosal immune response
subclass of: GO_0045087

natural killer cell mediated immunity
IAO_0000115: The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
has exact synonym: NK cell mediated immunity
type: Class
subclass of: lymphocyte mediated immunity
subclass of: GO_0045087

defense response to oomycetes
IAO_0000115: Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.
type: Class
subclass of: response to oomycetes
subclass of: GO_0098542

positive regulation of defense response to virus by host
IAO_0000115: Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
has exact synonym: positive regulation of antiviral response by host
has exact synonym: up regulation of antiviral response by host
has exact synonym: up-regulation of antiviral response by host
has exact synonym: upregulation of antiviral response by host
has related synonym: activation of antiviral response by host
has related synonym: stimulation of antiviral response by host
type: Class
subclass of: GO_0050691

detection of oomycetes
IAO_0000115: The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal.
type: Class
subclass of: response to oomycetes
subclass of: GO_0098543

leukocyte chemotaxis involved in inflammatory response
IAO_0000115: The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
has related synonym: immune cell chemotaxis during inflammatory response
has related synonym: leucocyte chemotaxis during inflammatory response
has related synonym: leukocyte chemotaxis during inflammatory response
type: Class
subclass of: part-of-parent-6954
subclass of: leukocyte migration involved in inflammatory response
subclass of: GO_0030595

leukocyte chemotaxis involved in immune response
IAO_0000115: The movement of an immune cell in response to an external stimulus a part of an immune response.
has exact synonym: immune cell chemotaxis during immune response
has exact synonym: leucocyte chemotaxis during immune response
type: Class
subclass of: part-of-parent-6955
subclass of: leukocyte migration involved in immune response
subclass of: GO_0030595

detection of endoplasmic reticulum overloading
IAO_0000115: The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.
has exact synonym: detection of ER overloading
type: Class
subclass of: GO_0006983
subclass of: GO_0009595

detection of unfolded protein
IAO_0000115: The series of events in which an unfolded protein stimulus is received and converted into a molecular signal.
type: Class
subclass of: GO_0006986
subclass of: GO_0009593

detection of misfolded protein
IAO_0000115: The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.
type: Class
subclass of: GO_0009593
subclass of: GO_0051788

response to molecule of bacterial origin
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
has exact synonym: response to bacteria associated molecule
has exact synonym: response to bacterial associated molecule
has exact synonym: response to bacterium associated molecule
type: Class
subclass of: part-of-parent-9617
subclass of: GO_0010033
subclass of: GO_0043207

response to molecule of fungal origin
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
has exact synonym: response to fungus associated molecule
type: Class
subclass of: part-of-parent-9620
subclass of: GO_0010033
subclass of: GO_0043207

response to oomycetes
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes.
type: Class
subclass of: GO_0051707

response to molecule of oomycetes origin
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin.
has exact synonym: response to oomycetes associated molecule
type: Class
subclass of: part-of-parent-2239
subclass of: GO_0010033
subclass of: GO_0043207

response to parasitic plant
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant.
type: Class
subclass of: GO_0009608

defense response to parasitic plant
IAO_0000115: Reactions triggered in response to the presence of a parasitic plant that act to protect an organism.
type: Class
subclass of: response to parasitic plant
subclass of: GO_0098542

detection of parasitic plant
IAO_0000115: The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal.
type: Class
subclass of: response to parasitic plant
subclass of: GO_0009602

hematopoietic progenitor cell differentiation
IAO_0000115: The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
has exact synonym: haematopoietic progenitor cell differentiation
has exact synonym: haemopoietic progenitor cell differentiation
has exact synonym: hemopoietic progenitor cell differentiation
type: Class
subclass of: part-of-parent-30097
subclass of: GO_0030154

wound healing involved in inflammatory response
IAO_0000115: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
has related synonym: healing during inflammatory response
has related synonym: inflammatory response wound healing
type: Class
subclass of: part-of-parent-6954
subclass of: part-of-parent-90594
subclass of: GO_0042060

clearance of damaged tissue involved in inflammatory response wound healing
IAO_0000115: The series of events leading to removal of necrotic debris that contribute to an inflammatory response.
has related synonym: clearance of damaged tissue during inflammatory response
type: Class
subclass of: part-of-parent-2246
subclass of: GO_0048771

connective tissue replacement involved in inflammatory response wound healing
IAO_0000115: The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.
has related synonym: connective tissue replacement during inflammatory response
has related synonym: fibrosis during inflammatory response
type: Class
subclass of: part-of-parent-2246
subclass of: GO_0097709

lymphocyte anergy
IAO_0000115: Any process contributing to lymphocyte anergy, a state of functional inactivation.
type: Class
subclass of: tolerance induction

adaptive immune response
IAO_0000115: An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
has exact synonym: acquired immune response
has exact synonym: immune memory response
type: Class
subclass of: GO_0006955

organ or tissue specific immune response
IAO_0000115: An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.
has exact synonym: immune response in organ or tissue
type: Class
subclass of: GO_0006955

immune effector process
IAO_0000115: Any process of the immune system that can potentially contribute to an immune response.
type: Class
subclass of: immune system process

activation of immune response
IAO_0000115: Any process that initiates an immune response.
type: Class
subclass of: immune system process
subclass of: GO_0050778

kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
type: Class
subclass of: acute inflammatory response
subclass of: GO_0072376

tissue kallikrein-kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
has exact synonym: glandular kallikrein-kinin cascade
type: Class
subclass of: kinin cascade

regulation of kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the kinin cascade.
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_2000257

negative regulation of kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.
has exact synonym: down regulation of kinin cascade
has exact synonym: down-regulation of kinin cascade
has exact synonym: downregulation of kinin cascade
has related synonym: inhibition of kinin cascade
type: Class
subclass of: regulation of kinin cascade
subclass of: negative regulation of acute inflammatory response
subclass of: GO_2000258

positive regulation of kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the kinin cascade.
has exact synonym: up regulation of kinin cascade
has exact synonym: up-regulation of kinin cascade
has exact synonym: upregulation of kinin cascade
has related synonym: activation of kinin cascade
has related synonym: stimulation of kinin cascade
type: Class
subclass of: regulation of kinin cascade
subclass of: positive regulation of acute inflammatory response
subclass of: GO_2000259

endothelial cell activation within high endothelial venule involved in immune response
IAO_0000115: A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: endothelial cell activation within high endothelial venule during immune response
type: Class
subclass of: endothelial cell activation involved in immune response

lymphocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
type: Class
subclass of: leukocyte homeostasis

mucosal lymphocyte homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus.
type: Class
subclass of: lymphocyte homeostasis

myeloid cell homeostasis
IAO_0000115: The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
type: Class
subclass of: immune system process
subclass of: GO_0048872

cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: cell activation during immune response
type: Class
subclass of: cell activation
subclass of: immune effector process
subclass of: part-of-parent-6955

endothelial cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: endothelial cell activation during immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042118

astrocyte activation involved in immune response
IAO_0000115: A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: astrocyte activation during immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0048143

follicular dendritic cell activation
IAO_0000115: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
type: Class
subclass of: cell activation

follicular dendritic cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: follicular dendritic cell activation during immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: follicular dendritic cell activation
subclass of: part-of-parent-6955

follicular dendritic cell differentiation
IAO_0000115: The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.
type: Class
subclass of: follicular dendritic cell activation
subclass of: GO_0030154

leukocyte activation involved in inflammatory response
IAO_0000115: A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
has related synonym: immune cell activation during inflammatory response
has related synonym: leukocyte activation during inflammatory response
type: Class
subclass of: part-of-parent-6954
subclass of: GO_0045321

plasmacytoid dendritic cell activation
IAO_0000115: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
type: Class
subclass of: GO_0045321

plasmacytoid dendritic cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: plasmacytoid dendritic cell activation during immune response
type: Class
subclass of: plasmacytoid dendritic cell activation
subclass of: part-of-parent-6955
subclass of: leukocyte activation involved in immune response

plasmacytoid dendritic cell differentiation involved in immune response
IAO_0000115: The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response.
has related synonym: plasmacytoid dendritic cell differentiation during immune response
type: Class
subclass of: plasmacytoid dendritic cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: plasmacytoid dendritic cell differentiation

plasmacytoid dendritic cell differentiation
IAO_0000115: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.
type: Class
subclass of: plasmacytoid dendritic cell activation
subclass of: GO_0097028

myeloid leukocyte activation
IAO_0000115: A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
has exact synonym: myeloid leucocyte activation
type: Class
subclass of: GO_0045321

myeloid cell activation involved in immune response
IAO_0000115: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
has related synonym: myeloid cell activation during immune response
type: Class
subclass of: myeloid leukocyte activation
subclass of: leukocyte activation involved in immune response

basophil activation involved in immune response
IAO_0000115: A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
has related synonym: basophil activation during immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0045575

myeloid dendritic cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: myeloid dendritic cell activation during immune response
type: Class
subclass of: myeloid dendritic cell activation
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955

eosinophil activation involved in immune response
IAO_0000115: The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: eosinophil activation during immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0043307

mast cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.
has related synonym: mast cell activation during immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0045576

monocyte activation involved in immune response
IAO_0000115: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: monocyte activation during immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042117

macrophage activation involved in immune response
IAO_0000115: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has exact synonym: macrophage polarization involved in immune response
has related synonym: macrophage activation during immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042116

microglial cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: microglial cell activation during immune response
type: Class
subclass of: microglial cell activation
subclass of: macrophage activation involved in immune response
subclass of: part-of-parent-6955

neutrophil activation involved in immune response
IAO_0000115: The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: neutrophil activation during immune response
type: Class
subclass of: myeloid cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042119

myeloid dendritic cell differentiation involved in immune response
IAO_0000115: The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.
has related synonym: myeloid dendritic cell differentiation during immune response
type: Class
subclass of: myeloid dendritic cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0043011

lymphocyte activation involved in immune response
IAO_0000115: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: lymphocyte activation during immune response
type: Class
subclass of: part-of-parent-6955
subclass of: leukocyte activation involved in immune response
subclass of: GO_0046649

T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: T cell activation during immune response
has related synonym: T lymphocyte activation during immune response
has related synonym: T-cell activation during immune response
has related synonym: T-lymphocyte activation during immune response
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042110

alpha-beta T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: alpha-beta T cell activation during immune response
has related synonym: alpha-beta T lymphocyte activation during immune response
has related synonym: alpha-beta T-cell activation during immune response
has related synonym: alpha-beta T-lymphocyte activation during immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0046631

NK T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: NK T cell activation during immune response
has related synonym: NK T lymphocyte activation during immune response
has related synonym: NK T-cell activation during immune response
has related synonym: NK T-lymphocyte activation during immune response
has related synonym: natural killer T lymphocyte activation during immune response
has related synonym: natural killer T-cell activation during immune response
has related synonym: natural killer T-lymphocyte activation during immune response
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0051132

NK T cell proliferation involved in immune response
IAO_0000115: The expansion of a NK T cell population by cell division as part of an immune response.
has related synonym: NK T cell proliferation during immune response
has related synonym: NK T lymphocyte proliferation during immune response
has related synonym: NK T-cell proliferation during immune response
has related synonym: NK T-lymphocyte proliferation during immune response
has related synonym: natural killer T lymphocyte proliferation during immune response
has related synonym: natural killer T-cell proliferation during immune response
has related synonym: natural killer T-lymphocyte proliferation during immune response
type: Class
subclass of: NK T cell proliferation
subclass of: NK T cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: alpha-beta T cell proliferation involved in immune response

gamma-delta T cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
has related synonym: gamma-delta T cell activation during immune response
has related synonym: gamma-delta T lymphocyte activation during immune response
has related synonym: gamma-delta T-cell activation during immune response
has related synonym: gamma-delta T-lymphocyte activation during immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0046629

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
IAO_0000115: The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
has exact synonym: T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has exact synonym: T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
has exact synonym: T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
type: Class
subclass of: T cell activation involved in immune response

T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: T cell development involved in immune response
has related synonym: T cell differentiation during immune response
has related synonym: T lymphocyte differentiation during immune response
has related synonym: T-cell differentiation during immune response
has related synonym: T-lymphocyte differentiation during immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0030217

alpha-beta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: alpha-beta T cell development involved in immune response
has related synonym: alpha-beta T cell differentiation during immune response
has related synonym: alpha-beta T lymphocyte differentiation during immune response
has related synonym: alpha-beta T-cell differentiation during immune response
has related synonym: alpha-beta T-lymphocyte differentiation during immune response
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: T cell differentiation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0046632

CD4-positive, alpha-beta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: CD4-positive, alpha-beta T cell development involved in immune response
has related synonym: CD4-positive, alpha-beta T cell differentiation during immune response
has related synonym: CD4-positive, alpha-beta T lymphocyte differentiation during immune response
has related synonym: CD4-positive, alpha-beta T-cell differentiation during immune response
has related synonym: CD4-positive, alpha-beta T-lymphocyte differentiation during immune response
type: Class
subclass of: alpha-beta T cell differentiation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0043367

T-helper cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.
has exact synonym: T-helper cell fate commitment
has related synonym: Th0 lineage commitment
has related synonym: Thp lineage commitment
type: Class
subclass of: part-of-parent-42093
subclass of: GO_0043373

T-helper 1 cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
has exact synonym: T-helper 1 cell fate commitment
has exact synonym: Th1 cell lineage commitment
has exact synonym: Th1 fate commitment
type: Class
subclass of: T-helper cell lineage commitment
subclass of: part-of-parent-45063

T-helper 2 cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy.
has exact synonym: T-helper 2 cell fate commitment
has exact synonym: Th2 fate commitment
type: Class
subclass of: T-helper cell lineage commitment
subclass of: part-of-parent-45064

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response.
has related synonym: CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response
type: Class
subclass of: CD4-positive, alpha-beta T cell differentiation involved in immune response
subclass of: part-of-parent-6955
subclass of: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

alpha-beta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: alpha-beta intraepithelial T-cell differentiation
has exact synonym: alpha-beta intraepithelial T-lymphocyte differentiation
has related synonym: alpha-beta intraepithelial T cell development
type: Class
subclass of: GO_0046632

CD8-positive, alpha-beta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta intraepithelial T-cell differentiation
has exact synonym: CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation
has related synonym: CD8-positive, alpha-beta intraepithelial T cell development
type: Class
subclass of: alpha-beta intraepithelial T cell differentiation
subclass of: GO_0043374

CD4-positive, alpha-beta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation
has exact synonym: CD4-positive, alpha-beta intraepithelial T-cell differentiation
has exact synonym: CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation
has related synonym: CD4-positive, alpha-beta intraepithelial T cell development
type: Class
subclass of: alpha-beta intraepithelial T cell differentiation
subclass of: GO_0043367

CD8-positive, alpha-beta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: CD8-positive, alpha-beta T cell differentiation during immune response
has related synonym: CD8-positive, alpha-beta T lymphocyte differentiation during immune response
has related synonym: CD8-positive, alpha-beta T-cell differentiation during immune response
has related synonym: CD8-positive, alpha-beta T-lymphocyte differentiation during immune response
has related synonym: CD8-positive, alpha-beta intraepithelial T cell development
type: Class
subclass of: alpha-beta T cell differentiation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0043374

gamma-delta T cell differentiation involved in immune response
IAO_0000115: The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
has related synonym: gamma-delta T cell development involved in immune response
has related synonym: gamma-delta T cell differentiation during immune response
has related synonym: gamma-delta T lymphocyte differentiation during immune response
has related synonym: gamma-delta T-cell differentiation during immune response
has related synonym: gamma-delta T-lymphocyte differentiation during immune response
type: Class
subclass of: gamma-delta T cell activation involved in immune response
subclass of: T cell differentiation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042492

gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: gamma-delta intraepithelial T-cell differentiation
has exact synonym: gamma-delta intraepithelial T-lymphocyte differentiation
has related synonym: gamma-delta intraepithelial T cell development
type: Class
subclass of: GO_0042492

CD8-positive, gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: CD8-positive, gamma-delta intraepithelial T-cell differentiation
has exact synonym: CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation
has related synonym: CD8-positive, gamma-delta intraepithelial T cell development
type: Class
subclass of: gamma-delta intraepithelial T cell differentiation

CD4-positive gamma-delta intraepithelial T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
has exact synonym: CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation
has exact synonym: CD4-positive, gamma-delta intraepithelial T-cell differentiation
has exact synonym: CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation
has related synonym: CD4-positive, gamma-delta intraepithelial T cell development
type: Class
subclass of: gamma-delta intraepithelial T cell differentiation

CD8-positive, alpha-beta regulatory T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell.
has exact synonym: CD8-positive, alpha-beta regulatory T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta regulatory T-cell differentiation
has exact synonym: CD8-positive, alpha-beta regulatory T-lymphocyte differentiation
has related synonym: CD8-positive, alpha-beta regulatory T cell development
type: Class
subclass of: GO_0043374
subclass of: GO_0045066

CD8-positive, alpha-beta cytotoxic T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell.
has exact synonym: CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation
has exact synonym: CD8-positive, alpha-beta cytotoxic T-cell differentiation
has exact synonym: CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation
has related synonym: CD8-positive, alpha-beta cytotoxic T cell development
type: Class
subclass of: GO_0043374
subclass of: GO_0045065

T cell proliferation involved in immune response
IAO_0000115: The expansion of a T cell population by cell division as part of an immune response.
has related synonym: T cell proliferation during immune response
has related synonym: T lymphocyte proliferation during immune response
has related synonym: T-cell proliferation during immune response
has related synonym: T-lymphocyte proliferation during immune response
type: Class
subclass of: T cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042098

alpha-beta T cell proliferation involved in immune response
IAO_0000115: The expansion of an alpha-beta T cell population by cell division as part of an immune response.
has related synonym: alpha-beta T cell proliferation during immune response
has related synonym: alpha-beta T lymphocyte proliferation during immune response
has related synonym: alpha-beta T-cell proliferation during immune response
has related synonym: alpha-beta T-lymphocyte proliferation during immune response
type: Class
subclass of: alpha-beta T cell activation involved in immune response
subclass of: T cell proliferation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0046633

gamma-delta T cell proliferation involved in immune response
IAO_0000115: The expansion of a gamma-delta T cell population by cell division as part of an immune response.
has related synonym: gamma-delta T cell proliferation during immune response
has related synonym: gamma-delta T lymphocyte proliferation during immune response
has related synonym: gamma-delta T-cell proliferation during immune response
has related synonym: gamma-delta T-lymphocyte proliferation during immune response
type: Class
subclass of: gamma-delta T cell activation involved in immune response
subclass of: T cell proliferation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0046630

B cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
has related synonym: B cell activation during immune response
has related synonym: B lymphocyte activation during immune response
has related synonym: B-cell activation during immune response
has related synonym: B-lymphocyte activation during immune response
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042113

mature B cell differentiation involved in immune response
IAO_0000115: The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.
has related synonym: mature B cell development involved in immune response
has related synonym: mature B cell differentiation during immune response
has related synonym: mature B lymphocyte differentiation during immune response
has related synonym: mature B-cell differentiation during immune response
has related synonym: mature B-lymphocyte differentiation during immune response
type: Class
subclass of: B cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: mature B cell differentiation

germinal center B cell differentiation
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
has exact synonym: germinal center B lymphocyte differentiation
has exact synonym: germinal center B-cell differentiation
has exact synonym: germinal center B-lymphocyte differentiation
has related synonym: germinal center B cell development
type: Class
subclass of: mature B cell differentiation involved in immune response

marginal zone B cell differentiation
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
has exact synonym: marginal zone B lymphocyte differentiation
has exact synonym: marginal zone B-cell differentiation
has exact synonym: marginal zone B-lymphocyte differentiation
has related synonym: marginal zone B cell development
type: Class
subclass of: mature B cell differentiation involved in immune response

follicular B cell differentiation
IAO_0000115: The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.
has exact synonym: follicular B lymphocyte differentiation
has exact synonym: follicular B-cell differentiation
has exact synonym: follicular B-lymphocyte differentiation
has related synonym: follicular B cell development
type: Class
subclass of: mature B cell differentiation involved in immune response

plasma cell differentiation
IAO_0000115: The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
has related synonym: plasma cell development
type: Class
subclass of: mature B cell differentiation involved in immune response

myeloid progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.
type: Class
subclass of: hematopoietic progenitor cell differentiation

memory B cell differentiation
IAO_0000115: The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.
has exact synonym: memory B lymphocyte differentiation
has exact synonym: memory B-cell differentiation
has exact synonym: memory B-lymphocyte differentiation
has related synonym: memory B cell development
type: Class
subclass of: mature B cell differentiation involved in immune response
subclass of: GO_0090715

lymphoid progenitor cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.
type: Class
subclass of: hematopoietic progenitor cell differentiation

natural killer cell progenitor differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.
type: Class
subclass of: lymphoid progenitor cell differentiation

B cell proliferation involved in immune response
IAO_0000115: The expansion of a B cell population by cell division following B cell activation during an immune response.
has related synonym: B cell proliferation during immune response
has related synonym: B lymphocyte proliferation during immune response
has related synonym: B-cell proliferation during immune response
has related synonym: B-lymphocyte proliferation during immune response
type: Class
subclass of: B cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0042100

natural killer cell activation involved in immune response
IAO_0000115: The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: NK cell activation during immune response
has related synonym: natural killer cell activation during immune response
type: Class
subclass of: lymphocyte activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0030101

natural killer cell proliferation involved in immune response
IAO_0000115: The expansion of a natural killer cell population by cell division as part of an immune response.
has related synonym: NK cell proliferation during immune response
has related synonym: natural killer cell proliferation during immune response
type: Class
subclass of: natural killer cell proliferation
subclass of: natural killer cell activation involved in immune response
subclass of: part-of-parent-6955

natural killer cell differentiation involved in immune response
IAO_0000115: The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.
has related synonym: NK cell differentiation during immune response
has related synonym: natural killer cell development involved in immune response
has related synonym: natural killer cell differentiation during immune response
type: Class
subclass of: natural killer cell differentiation
subclass of: natural killer cell activation involved in immune response
subclass of: part-of-parent-6955

B cell lineage commitment
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.
has exact synonym: B lymphocyte lineage commitment
has exact synonym: B-cell lineage commitment
has exact synonym: B-lymphocyte lineage commitment
type: Class
subclass of: part-of-parent-30183
subclass of: GO_0045165

immature B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of an immature B cell.
has exact synonym: immature B lymphocyte differentiation
has exact synonym: immature B-cell differentiation
has exact synonym: immature B-lymphocyte differentiation
has related synonym: immature B cell development
type: Class
subclass of: GO_0030183

pro-B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
has exact synonym: pro-B lymphocyte differentiation
has related synonym: pro-B cell development
type: Class
subclass of: lymphoid progenitor cell differentiation

pre-B cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
has exact synonym: pre-B lymphocyte differentiation
has related synonym: pre-B cell development
type: Class
subclass of: immature B cell differentiation

pre-B cell receptor expression
IAO_0000115: The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface.
type: Class
subclass of: part-of-parent-2329
subclass of: GO_0010467

pre-B cell allelic exclusion
IAO_0000115: Expression of a single heavy chain allele during pre-B cell differentiation.
has exact synonym: pre-B lymphocyte allelic exclusion
type: Class
subclass of: part-of-parent-2329
subclass of: GO_0010468

transitional stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.
has exact synonym: transitional stage B lymphocyte differentiation
has exact synonym: transitional stage B-cell differentiation
has exact synonym: transitional stage B-lymphocyte differentiation
has related synonym: transitional stage B cell development
type: Class
subclass of: immature B cell differentiation

transitional one stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
has exact synonym: T1 stage B cell differentiation
has exact synonym: transitional one stage B lymphocyte differentiation
has exact synonym: transitional one stage B-cell differentiation
has exact synonym: transitional one stage B-lymphocyte differentiation
has related synonym: transitional one stage B cell development
type: Class
subclass of: transitional stage B cell differentiation

transitional two stage B cell differentiation
IAO_0000115: The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.
has exact synonym: T2 stage B cell differentiation
has exact synonym: transitional two stage B lymphocyte differentiation
has exact synonym: transitional two stage B-cell differentiation
has exact synonym: transitional two stage B-lymphocyte differentiation
has related synonym: transitional two stage B cell development
type: Class
subclass of: transitional stage B cell differentiation

mature B cell differentiation
IAO_0000115: The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
has exact synonym: mature B lymphocyte differentiation
has exact synonym: mature B-cell differentiation
has exact synonym: mature B-lymphocyte differentiation
has related synonym: mature cell development
type: Class
subclass of: GO_0030183

B-1 B cell lineage commitment
IAO_0000115: The process in which an immature B cell becomes committed to become a B-1 B cell.
has exact synonym: B-1 B lymphocyte lineage commitment
has exact synonym: B-1 B-cell lineage commitment
has exact synonym: B-1 B-lymphocyte lineage commitment
type: Class
subclass of: B cell lineage commitment
subclass of: part-of-parent-1923

B-1a B cell differentiation
IAO_0000115: The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
has exact synonym: B-1a B lymphocyte differentiation
has exact synonym: B-1a B-cell differentiation
has exact synonym: B-1a B-lymphocyte differentiation
has related synonym: B-1a B cell development
type: Class
subclass of: B-1 B cell differentiation

B-1b B cell differentiation
IAO_0000115: The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.
has exact synonym: B-1b B lymphocyte differentiation
has exact synonym: B-1b B-cell differentiation
has exact synonym: B-1b B-lymphocyte differentiation
has related synonym: B-1b B cell development
type: Class
subclass of: B-1 B cell differentiation

B cell selection
IAO_0000115: The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
has exact synonym: B lymphocyte selection
has exact synonym: B-cell selection
has exact synonym: B-lymphocyte selection
type: Class
subclass of: part-of-parent-30183
subclass of: immune system process

central B cell selection
IAO_0000115: Any B cell selection process that occurs in the bone marrow.
has exact synonym: central B lymphocyte selection
has exact synonym: central B-cell selection
has exact synonym: central B-lymphocyte selection
type: Class
subclass of: B cell selection

central B cell anergy
IAO_0000115: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.
has exact synonym: central B lymphocyte anergy
has exact synonym: central B-cell anergy
has exact synonym: central B-lymphocyte anergy
type: Class
subclass of: part-of-parent-2340
subclass of: part-of-parent-2510
subclass of: B cell anergy

central B cell deletion
IAO_0000115: The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.
has exact synonym: central B lymphocyte deletion
has exact synonym: central B-cell deletion
has exact synonym: central B-lymphocyte deletion
type: Class
subclass of: part-of-parent-2340
subclass of: part-of-parent-2510
subclass of: B cell deletion

peripheral B cell selection
IAO_0000115: Any B cell selection process that occurs in the periphery.
has exact synonym: peripheral B lymphocyte selection
has exact synonym: peripheral B-cell selection
has exact synonym: peripheral B-lymphocyte selection
type: Class
subclass of: B cell selection

B cell affinity maturation
IAO_0000115: The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
has exact synonym: B lymphocyte affinity maturation
has exact synonym: B-cell affinity maturation
has exact synonym: B-lymphocyte affinity maturation
type: Class
subclass of: peripheral B cell selection
subclass of: part-of-parent-2381

peripheral B cell receptor editing
IAO_0000115: The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.
has exact synonym: peripheral B lymphocyte receptor editing
has exact synonym: peripheral B-cell receptor editing
has exact synonym: peripheral B-lymphocyte receptor editing
type: Class
subclass of: B cell receptor editing

B cell positive selection
IAO_0000115: Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor.
has exact synonym: B lymphocyte positive selection
has exact synonym: B-cell positive selection
has exact synonym: B-lymphocyte positive selection
type: Class
subclass of: B cell selection

response to tumor cell
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.
type: Class
subclass of: GO_0009607

central B cell positive selection
IAO_0000115: Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
has exact synonym: central B lymphocyte positive selection
has exact synonym: central B-cell positive selection
has exact synonym: central B-lymphocyte positive selection
type: Class
subclass of: central B cell selection
subclass of: B cell positive selection

histamine production involved in inflammatory response
IAO_0000115: The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: histamine production involved in acute inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response

peripheral B cell positive selection
IAO_0000115: Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
has exact synonym: peripheral B lymphocyte positive selection
has exact synonym: peripheral B-cell positive selection
has exact synonym: peripheral B-lymphocyte positive selection
type: Class
subclass of: peripheral B cell selection
subclass of: B cell positive selection

serotonin production involved in inflammatory response
IAO_0000115: The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: serotonin production involved in acute inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response

B cell negative selection
IAO_0000115: Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.
has exact synonym: B lymphocyte negative selection
has exact synonym: B-cell negative selection
has exact synonym: B-lymphocyte negative selection
type: Class
subclass of: B cell selection

plasma kallikrein-kinin cascade
IAO_0000115: A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
type: Class
subclass of: kinin cascade

central B cell negative selection
IAO_0000115: Any process leading to negative selection of B cells in the bone marrow.
has exact synonym: central B lymphocyte negative selection
has exact synonym: central B-cell negative selection
has exact synonym: central B-lymphocyte negative selection
type: Class
subclass of: central B cell selection
subclass of: B cell negative selection

detection of tumor cell
IAO_0000115: The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.
type: Class
subclass of: response to tumor cell
subclass of: GO_0009595

peripheral B cell negative selection
IAO_0000115: Any process leading to negative selection of B cells in the periphery.
has exact synonym: peripheral B lymphocyte negative selection
has exact synonym: peripheral B-cell negative selection
has exact synonym: peripheral B-lymphocyte negative selection
type: Class
subclass of: peripheral B cell selection
subclass of: B cell negative selection

defense response to tumor cell
IAO_0000115: Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
type: Class
subclass of: response to tumor cell
subclass of: GO_0006952

B cell homeostatic proliferation
IAO_0000115: The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.
has exact synonym: B lymphocyte homeostatic proliferation
has exact synonym: B-cell homeostatic proliferation
has exact synonym: B-lymphocyte homeostatic proliferation
type: Class
subclass of: part-of-parent-42592
subclass of: GO_0042100

B-1 B cell proliferation
IAO_0000115: The expansion of a B-1 B cell by cell division. Follows B cell activation.
has exact synonym: B-1 B lymphocyte proliferation
has exact synonym: B-1 B-cell proliferation
has exact synonym: B-1 B-lymphocyte proliferation
type: Class
subclass of: GO_0042100

T cell lineage commitment
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
has exact synonym: T lymphocyte lineage commitment
has exact synonym: T-cell lineage commitment
has exact synonym: T-lymphocyte lineage commitment
type: Class
subclass of: part-of-parent-30217
subclass of: GO_0045165

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation
has related synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell development
type: Class
subclass of: GO_0043367
subclass of: GO_0045066

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
IAO_0000115: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment
has exact synonym: CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment
type: Class
subclass of: part-of-parent-2361
subclass of: GO_0043373

alpha-beta T cell lineage commitment
IAO_0000115: The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.
has exact synonym: alpha-beta T lymphocyte lineage commitment
has exact synonym: alpha-beta T-cell lineage commitment
has exact synonym: alpha-beta T-lymphocyte lineage commitment
type: Class
subclass of: T cell lineage commitment
subclass of: part-of-parent-46632

NK T cell lineage commitment
IAO_0000115: The process in which a pro-T cell becomes committed to becoming an NK T cell.
has exact synonym: NK T lymphocyte lineage commitment
has exact synonym: NK T-cell lineage commitment
has exact synonym: NK T-lymphocyte lineage commitment
has exact synonym: natural killer T lymphocyte lineage commitment
has exact synonym: natural killer T-cell lineage commitment
has exact synonym: natural killer T-lymphocyte lineage commitment
type: Class
subclass of: alpha-beta T cell lineage commitment
subclass of: part-of-parent-1865

gamma-delta T cell lineage commitment
IAO_0000115: The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.
has exact synonym: gamma-delta T lymphocyte lineage commitment
has exact synonym: gamma-delta T-cell lineage commitment
has exact synonym: gamma-delta T-lymphocyte lineage commitment
type: Class
subclass of: T cell lineage commitment
subclass of: part-of-parent-42492

leukocyte activation involved in immune response
IAO_0000115: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
has related synonym: immune cell activation during immune response
has related synonym: leucocyte activation during immune response
has related synonym: leukocyte activation during immune response
type: Class
subclass of: cell activation involved in immune response
subclass of: part-of-parent-6955
subclass of: GO_0045321

cytokine production involved in immune response
IAO_0000115: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: cytokine production during immune response
type: Class
subclass of: cytokine production
subclass of: part-of-parent-6955
subclass of: production of molecular mediator of immune response

B cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a B cell.
has exact synonym: B lymphocyte cytokine production
has exact synonym: B-cell cytokine production
has exact synonym: B-lymphocyte cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: GO_0019724

T cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a T cell.
has exact synonym: T lymphocyte cytokine production
has exact synonym: T-cell cytokine production
has exact synonym: T-lymphocyte cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: T cell mediated immunity

natural killer cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a natural killer cell.
has exact synonym: NK cell cytokine production
type: Class
subclass of: natural killer cell mediated immunity
subclass of: cytokine production involved in immune response

dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a dendritic cell.
type: Class
subclass of: cytokine production involved in immune response
subclass of: leukocyte mediated immunity

myeloid dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a myeloid dendritic cell.
type: Class
subclass of: dendritic cell cytokine production
subclass of: myeloid leukocyte mediated immunity
subclass of: GO_0061082

plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.
type: Class
subclass of: dendritic cell cytokine production

cytokine secretion involved in immune response
IAO_0000115: The regulated release of cytokines from a cell that contributes to an immune response.
has related synonym: cytokine secretion during immune response
type: Class
subclass of: part-of-parent-2367
subclass of: part-of-parent-6955
subclass of: GO_0050663

cytokine biosynthetic process involved in immune response
IAO_0000115: The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response.
has related synonym: cytokine biosynthetic process during immune response
type: Class
subclass of: part-of-parent-2367
subclass of: part-of-parent-6955
subclass of: GO_0042089

immune system process
IAO_0000115: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
type: Class
subclass of: GO_0008150

immunoglobulin production
IAO_0000115: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has exact synonym: antibody production
type: Class
subclass of: production of molecular mediator of immune response

immunoglobulin biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of immunoglobulin.
has exact synonym: antibody biosynthesis
has exact synonym: antibody biosynthetic process
type: Class
subclass of: part-of-parent-2377
subclass of: GO_0009059

immunoglobulin biosynthetic process involved in immune response
IAO_0000115: The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response.
has related synonym: antibody biosynthesis during immune response
has related synonym: antibody biosynthetic process during immune response
has related synonym: immunoglobulin biosynthetic process during immune response
type: Class
subclass of: immunoglobulin biosynthetic process
subclass of: part-of-parent-2381

immunoglobulin secretion involved in immune response
IAO_0000115: The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response.
has related synonym: antibody secretion during immune response
has related synonym: immunoglobulin secretion during immune response
type: Class
subclass of: part-of-parent-2381
subclass of: GO_0048305

immunoglobulin production involved in immunoglobulin mediated immune response
IAO_0000115: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: antibody production during immune response
has related synonym: immunoglobulin production during immune response
has related synonym: immunoglobulin production involved in immune response
type: Class
subclass of: immunoglobulin production
subclass of: part-of-parent-16064

regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: regulation of glandular kallikrein-kinin cascade
type: Class
subclass of: regulation of kinin cascade

immune response in brain or nervous system
IAO_0000115: An immune response taking place in the brain or nervous system.
type: Class
subclass of: organ or tissue specific immune response

hepatic immune response
IAO_0000115: An immune response taking place in the liver.
type: Class
subclass of: organ or tissue specific immune response

mucosal immune response
IAO_0000115: An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
type: Class
subclass of: organ or tissue specific immune response

immune response in mucosal-associated lymphoid tissue
IAO_0000115: Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes.
has exact synonym: immune response in MALT
type: Class
subclass of: mucosal immune response

immune response in gut-associated lymphoid tissue
IAO_0000115: Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.
has exact synonym: immune response in GALT
type: Class
subclass of: immune response in mucosal-associated lymphoid tissue

immune response in Peyer's patch
IAO_0000115: Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine.
type: Class
subclass of: immune response in gut-associated lymphoid tissue

tolerance induction in Peyer's patch
IAO_0000115: Tolerance induction taking place in the Peyer's patches.
type: Class
subclass of: immune response in Peyer's patch
subclass of: tolerance induction in gut-associated lymphoid tissue

platelet activating factor production
IAO_0000115: The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels.
type: Class
subclass of: cytokine production

platelet activating factor production involved in inflammatory response
IAO_0000115: The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: platelet activating factor production involved in acute inflammatory response
type: Class
subclass of: platelet activating factor production
subclass of: part-of-parent-6954
subclass of: cytokine production involved in inflammatory response

platelet activating factor secretion
IAO_0000115: The regulated release of platelet activating factor by a cell.
type: Class
subclass of: GO_0010876
subclass of: GO_0015697
subclass of: GO_0015914
subclass of: GO_0050663
subclass of: GO_0140353

lysosomal enzyme production involved in inflammatory response
IAO_0000115: The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels.
has exact synonym: production of lysosomal enzymes involved in inflammatory response
has related synonym: lysosomal enzyme production involved in acute inflammatory response
has related synonym: production of lysosomal enzymes involved in acute inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response

tolerance induction in gut-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the gut-associated lymphoid tissue (GALT).
has exact synonym: tolerance induction in GALT
has related synonym: oral tolerance
type: Class
subclass of: immune response in gut-associated lymphoid tissue
subclass of: tolerance induction in mucosal-associated lymphoid tissue

immune response in nasopharyngeal-associated lymphoid tissue
IAO_0000115: An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.
has exact synonym: immune response in NALT
type: Class
subclass of: immune response in gut-associated lymphoid tissue

MHC protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.
type: Class
subclass of: GO_0034622

MHC class I protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.
type: Class
subclass of: MHC protein complex assembly

MHC class Ib protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules.
type: Class
subclass of: MHC protein complex assembly

MHC class II protein complex assembly
IAO_0000115: The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.
type: Class
subclass of: MHC protein complex assembly

tolerance induction in nasopharyngeal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).
has exact synonym: tolerance induction in NALT
has related synonym: nasal tolerance
type: Class
subclass of: tolerance induction in gut-associated lymphoid tissue
subclass of: immune response in nasopharyngeal-associated lymphoid tissue

tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).
has exact synonym: tolerance induction in MALT
type: Class
subclass of: immune response in mucosal-associated lymphoid tissue
subclass of: mucosal tolerance induction

B cell tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.
has exact synonym: B cell tolerance induction in MALT
type: Class
subclass of: tolerance induction in mucosal-associated lymphoid tissue
subclass of: peripheral B cell tolerance induction

T cell tolerance induction in mucosal-associated lymphoid tissue
IAO_0000115: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.
has exact synonym: T cell tolerance induction in MALT
type: Class
subclass of: tolerance induction in mucosal-associated lymphoid tissue
subclass of: peripheral T cell tolerance induction

antigen sampling in mucosal-associated lymphoid tissue
IAO_0000115: The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling in MALT
has related synonym: antigen transport in MALT
has related synonym: antigen transport in mucosal-associated lymphoid tissue
type: Class
subclass of: immune system process
subclass of: part-of-parent-2386

antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling by dendritic cells in MALT
type: Class
subclass of: antigen sampling in mucosal-associated lymphoid tissue
subclass of: part-of-parent-2468

antigen sampling by M cells in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue.
has exact synonym: antigen sampling by M cells in MALT
type: Class
subclass of: antigen sampling in mucosal-associated lymphoid tissue

dendritic cell chemotaxis
IAO_0000115: The movement of a dendritic cell in response to an external stimulus.
type: Class
subclass of: GO_0030595
subclass of: GO_0036336

myeloid dendritic cell chemotaxis
IAO_0000115: The movement of a myeloid dendritic cell in response to an external stimulus.
type: Class
subclass of: dendritic cell chemotaxis
subclass of: GO_0097529

Langerhans cell chemotaxis
IAO_0000115: The movement of a Langerhans cell in response to an external stimulus.
type: Class
subclass of: myeloid dendritic cell chemotaxis

plasmacytoid dendritic cell chemotaxis
IAO_0000115: The movement of a plasmacytoid dendritic cell in response to an external stimulus.
type: Class
subclass of: dendritic cell chemotaxis

T cell tolerance induction to tumor cell
IAO_0000115: A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor.
type: Class
subclass of: tolerance induction to tumor cell
subclass of: T cell mediated immune response to tumor cell
subclass of: peripheral T cell tolerance induction

antigen transcytosis by M cells in mucosal-associated lymphoid tissue
IAO_0000115: The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.
has exact synonym: antigen transcytosis by M cells in MALT
has exact synonym: antigen transport by M cells in MALT
has exact synonym: antigen transport by M cells in mucosal-associated lymphoid tissue
type: Class
subclass of: part-of-parent-2406
subclass of: GO_0045056

tolerance induction to tumor cell
IAO_0000115: A process of tolerance induction which leads to immunological tolerance of a tumor.
type: Class
subclass of: immune response to tumor cell
subclass of: peripheral tolerance induction

immunoglobulin transcytosis in epithelial cells
IAO_0000115: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.
type: Class
subclass of: GO_0045056

immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
IAO_0000115: The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
has exact synonym: antibody transcytosis mediated by pIgR
has exact synonym: immunoglobulin transcytosis mediated by pIgR
type: Class
subclass of: immunoglobulin transcytosis in epithelial cells
subclass of: part-of-parent-2386

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
IAO_0000115: The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
has exact synonym: IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
has exact synonym: IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor
type: Class
subclass of: immunoglobulin transcytosis in epithelial cells

B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
IAO_0000115: B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor.
has exact synonym: B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
has exact synonym: B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen
has exact synonym: B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
type: Class
subclass of: B cell antigen processing and presentation
subclass of: antigen processing and presentation following receptor mediated endocytosis

immune response to tumor cell
IAO_0000115: An immune system process that functions in the response of an organism to a tumor cell.
type: Class
subclass of: response to tumor cell
subclass of: GO_0006955

T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: T lymphocyte mediated cytotoxicity directed against tumor cell target
has exact synonym: T-cell mediated cytotoxicity directed against tumor cell target
has exact synonym: T-lymphocyte mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: T cell mediated cytotoxicity
subclass of: T cell mediated immune response to tumor cell

natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
has exact synonym: NK cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: natural killer cell mediated immune response to tumor cell
subclass of: GO_0042267

B cell antigen processing and presentation following pinocytosis
IAO_0000115: B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
has exact synonym: B lymphocyte antigen processing and presentation following pinocytosis
has exact synonym: B-cell antigen processing and presentation following pinocytosis
has exact synonym: B-lymphocyte antigen processing and presentation following pinocytosis
type: Class
subclass of: B cell antigen processing and presentation
subclass of: antigen processing and presentation following pinocytosis

immune response in urogenital tract
IAO_0000115: An immune response taking place in the urogenital tract. The urogenital tract.
type: Class
subclass of: mucosal immune response

natural killer cell mediated immune response to tumor cell
IAO_0000115: An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell.
type: Class
subclass of: natural killer cell mediated immunity
subclass of: immune response to tumor cell

T cell mediated immune response to tumor cell
IAO_0000115: An immune response mediated by a T cell triggered in response to the presence of a tumor cell.
type: Class
subclass of: immune response to tumor cell
subclass of: T cell mediated immunity

tolerance induction in urogenital tract
IAO_0000115: Tolerance induction taking place in the urogenital tract.
type: Class
subclass of: immune response in urogenital tract
subclass of: mucosal tolerance induction

immunoglobulin production in mucosal tissue
IAO_0000115: The synthesis and release of immunoglobulin in the mucosal tissue.
has exact synonym: antibody production in mucosal tissue
type: Class
subclass of: immunoglobulin production involved in immunoglobulin mediated immune response
subclass of: part-of-parent-2385

mucosal tolerance induction
IAO_0000115: Tolerance induction taking place in the mucosal tissues.
type: Class
subclass of: mucosal immune response
subclass of: tolerance induction to nonself antigen

antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family.
has exact synonym: peptide antigen processing and presentation via MHC class Ib
type: Class
subclass of: antigen processing and presentation via MHC class Ib
subclass of: GO_0048002

immune response-activating cell surface receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.
has exact synonym: activation of immune response by cell surface receptor signaling pathway
has exact synonym: immune response-activating cell surface receptor signalling pathway
type: Class
subclass of: immune response-activating signal transduction
subclass of: immune response-regulating cell surface receptor signaling pathway

complement receptor mediated signaling pathway
IAO_0000115: A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
has exact synonym: complement receptor mediated signalling pathway
has related synonym: immune response-regulating cell surface receptor signalling pathway
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway

Fc receptor mediated stimulatory signaling pathway
IAO_0000115: A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
has exact synonym: Fc receptor mediated stimulatory signalling pathway
has exact synonym: Fc-receptor mediated stimulatory signaling pathway
type: Class
subclass of: immune response-activating cell surface receptor signaling pathway

granuloma formation
IAO_0000115: The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.
type: Class
subclass of: immune effector process
subclass of: part-of-parent-2544

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
IAO_0000115: An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
has exact synonym: immune response-regulating cell surface receptor signalling pathway involved in phagocytosis
has exact synonym: phagocytosis triggered by activation of immune response cell surface activating receptor
type: Class
subclass of: immune effector process
subclass of: part-of-parent-6909
subclass of: immune response-regulating cell surface receptor signaling pathway

immune complex clearance
IAO_0000115: A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.
type: Class
subclass of: immune effector process

immune complex clearance by erythrocytes
IAO_0000115: The process of immune complex clearance by erythrocytes.
has exact synonym: immune complex clearance by RBCs
has exact synonym: immune complex clearance by red blood cells
type: Class
subclass of: immune complex clearance

immune complex clearance by monocytes and macrophages
IAO_0000115: The process of immune complex clearance by monocytes or macrophages.
type: Class
subclass of: immune complex clearance

inflammatory response to antigenic stimulus
IAO_0000115: An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
type: Class
subclass of: GO_0006954
subclass of: GO_0006955

acute inflammatory response to antigenic stimulus
IAO_0000115: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
type: Class
subclass of: inflammatory response to antigenic stimulus
subclass of: acute inflammatory response

chronic inflammatory response to antigenic stimulus
IAO_0000115: A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.
type: Class
subclass of: inflammatory response to antigenic stimulus
subclass of: chronic inflammatory response

production of molecular mediator of immune response
IAO_0000115: The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: production of cellular mediator of immune response
type: Class
subclass of: immune system process

histamine secretion involved in inflammatory response
IAO_0000115: The regulated release of histamine by a cell as part of an inflammatory response.
has related synonym: histamine secretion involved in acute inflammatory response
type: Class
subclass of: histamine secretion
subclass of: part-of-parent-2349
subclass of: part-of-parent-6954
subclass of: GO_0046879

serotonin secretion involved in inflammatory response
IAO_0000115: The regulated release of serotonin by a cell as part of an inflammatory response.
has related synonym: serotonin release involved in inflammatory response
has related synonym: serotonin secretion involved in acute inflammatory response
type: Class
subclass of: serotonin secretion
subclass of: part-of-parent-2351
subclass of: part-of-parent-6954

leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a leukocyte.
has exact synonym: immune cell effector process
has exact synonym: immune cell mediated immunity
has exact synonym: leucocyte immune effector process
has exact synonym: leucocyte mediated immunity
has exact synonym: leukocyte immune effector process
has related synonym: cell-mediated immune response
has related synonym: cellular immune response
replaces: GO_0019723
replaces: GO_0042087
type: Class
subclass of: immune effector process

myeloid leukocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a myeloid leukocyte.
has exact synonym: myeloid leucocyte immune effector process
has exact synonym: myeloid leucocyte mediated immunity
has exact synonym: myeloid leukocyte immune effector process
type: Class
subclass of: leukocyte mediated immunity

type II hypersensitivity
IAO_0000115: An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
type: Class
subclass of: myeloid leukocyte mediated immunity
subclass of: hypersensitivity
subclass of: GO_0016064

neutrophil mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a neutrophil.
type: Class
subclass of: myeloid leukocyte mediated immunity

eosinophil mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by an eosinophil.
type: Class
subclass of: myeloid leukocyte mediated immunity

mast cell mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a mast cell.
type: Class
subclass of: myeloid leukocyte mediated immunity

lymphocyte mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a lymphocyte.
has related synonym: cell-mediated immunity
has related synonym: cellular immune response
type: Class
subclass of: leukocyte mediated immunity

B cell antigen processing and presentation
IAO_0000115: The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has exact synonym: B lymphocyte antigen processing and presentation
has exact synonym: B-cell antigen processing and presentation
has exact synonym: B-lymphocyte antigen processing and presentation
type: Class
subclass of: part-of-parent-19724
subclass of: GO_0019882

peripheral B cell tolerance induction
IAO_0000115: Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.
has exact synonym: peripheral B lymphocyte tolerance induction
has exact synonym: peripheral B-cell tolerance induction
has exact synonym: peripheral B-lymphocyte tolerance induction
type: Class
subclass of: peripheral tolerance induction
subclass of: B cell tolerance induction
subclass of: GO_0019724

B cell receptor editing
IAO_0000115: The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.
has exact synonym: B lymphocyte receptor editing
has exact synonym: B-cell receptor editing
has exact synonym: B-lymphocyte receptor editing
type: Class
subclass of: GO_0016447

peripheral B cell anergy
IAO_0000115: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells.
has exact synonym: peripheral B lymphocyte anergy
has exact synonym: peripheral B-cell anergy
has exact synonym: peripheral B-lymphocyte anergy
type: Class
subclass of: part-of-parent-2451
subclass of: B cell anergy

peripheral B cell deletion
IAO_0000115: The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection.
has exact synonym: peripheral B lymphocyte deletion
has exact synonym: peripheral B-cell deletion
has exact synonym: peripheral B-lymphocyte deletion
type: Class
subclass of: part-of-parent-2451
subclass of: B cell deletion

humoral immune response mediated by circulating immunoglobulin
IAO_0000115: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
has exact synonym: circulating antibody mediated immune response
has exact synonym: circulating immunoglobulin mediated immune response
has exact synonym: humoral immune response mediated by circulating antibody
has related synonym: humoral defence mechanism
type: Class
subclass of: GO_0006959
subclass of: GO_0016064

T cell mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a T cell.
has exact synonym: T lymphocyte mediated immunity
has exact synonym: T-cell mediated immunity
has exact synonym: T-lymphocyte mediated immunity
has related synonym: cell-mediated immunity
has related synonym: cellular immune response
type: Class
subclass of: lymphocyte mediated immunity
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

T cell antigen processing and presentation
IAO_0000115: The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
has exact synonym: T lymphocyte antigen processing and presentation
has exact synonym: T-cell antigen processing and presentation
has exact synonym: T-lymphocyte antigen processing and presentation
type: Class
subclass of: part-of-parent-2456
subclass of: GO_0019882

peripheral T cell tolerance induction
IAO_0000115: Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus.
has exact synonym: peripheral T lymphocyte tolerance induction
has exact synonym: peripheral T-cell tolerance induction
has exact synonym: peripheral T-lymphocyte tolerance induction
type: Class
subclass of: T cell mediated immunity
subclass of: peripheral tolerance induction
subclass of: T cell tolerance induction

adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
IAO_0000115: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae).
has exact synonym: adaptive immune response based on somatic recombination of VLR built from LRR domains
has exact synonym: adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains
has exact synonym: adaptive immune response in jawless fish
type: Class
subclass of: adaptive immune response

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
type: Class
subclass of: adaptive immune response

tolerance induction dependent upon immune response
IAO_0000115: Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.
has exact synonym: immune response-dependent tolerance induction
type: Class
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: tolerance induction

tolerance induction to nonself antigen
IAO_0000115: Tolerance induction in response to nonself antigens.
type: Class
subclass of: tolerance induction dependent upon immune response

central tolerance induction to nonself antigen
IAO_0000115: Tolerance induction to nonself antigens in the central lymphoid organs.
type: Class
subclass of: tolerance induction to nonself antigen
subclass of: central tolerance induction

peripheral tolerance induction to nonself antigen
IAO_0000115: Tolerance induction to nonself antigens in the periphery.
type: Class
subclass of: tolerance induction to nonself antigen
subclass of: peripheral tolerance induction

peripheral tolerance induction
IAO_0000115: Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
type: Class
subclass of: tolerance induction dependent upon immune response

peripheral tolerance induction to self antigen
IAO_0000115: Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
type: Class
subclass of: peripheral tolerance induction
subclass of: tolerance induction to self antigen

germinal center formation
IAO_0000115: The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.
type: Class
subclass of: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0048646

dendritic cell antigen processing and presentation
IAO_0000115: The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
type: Class
subclass of: GO_0019882

myeloid dendritic cell antigen processing and presentation
IAO_0000115: The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
type: Class
subclass of: dendritic cell antigen processing and presentation

plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
type: Class
subclass of: dendritic cell antigen processing and presentation

monocyte antigen processing and presentation
IAO_0000115: The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
type: Class
subclass of: GO_0019882

macrophage antigen processing and presentation
IAO_0000115: The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
type: Class
subclass of: GO_0019882

non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils.
type: Class
subclass of: GO_0019882

antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
has exact synonym: peptide antigen processing and presentation via MHC class I
type: Class
subclass of: GO_0048002

antigen processing and presentation via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.
type: Class
subclass of: GO_0019882

antigen processing and presentation of endogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib
type: Class
subclass of: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: antigen processing and presentation of endogenous peptide antigen

antigen processing and presentation of exogenous peptide antigen via MHC class Ib
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib
type: Class
subclass of: antigen processing and presentation of peptide antigen via MHC class Ib
subclass of: antigen processing and presentation of exogenous peptide antigen

antigen processing and presentation of exogenous peptide antigen
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.
has exact synonym: exogenous peptide antigen processing and presentation
type: Class
subclass of: GO_0019884
subclass of: GO_0048002

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
has exact synonym: TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I
has exact synonym: TAP-dependent exogenous peptide antigen processing and presentation via MHC class I
has exact synonym: exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent
has related synonym: cross presentation
has related synonym: cross-presentation
type: Class
subclass of: GO_0042590

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.
has exact synonym: TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I
has exact synonym: TAP-independent exogenous peptide antigen processing and presentation via MHC class I
has exact synonym: exogenous peptide antigen processing and presentation via MHC class I, TAP-independent
has related synonym: cross presentation
has related synonym: cross-presentation
type: Class
subclass of: GO_0042590

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib
has exact synonym: TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent
type: Class
subclass of: antigen processing and presentation of exogenous peptide antigen via MHC class Ib

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib
has exact synonym: TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib
has exact synonym: exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent
type: Class
subclass of: antigen processing and presentation of exogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.
has exact synonym: endogenous peptide antigen processing and presentation
type: Class
subclass of: GO_0019883
subclass of: GO_0048002

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway
type: Class
subclass of: GO_0019885

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.
has exact synonym: TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
has exact synonym: TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.
has exact synonym: TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
has exact synonym: TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway
type: Class
subclass of: GO_0019885

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
has exact synonym: TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
has exact synonym: TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
has exact synonym: TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway
has exact synonym: endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

antigen processing and presentation of endogenous peptide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
has exact synonym: endogenous peptide antigen processing and presentation via MHC class II
type: Class
subclass of: antigen processing and presentation of endogenous peptide antigen
subclass of: antigen processing and presentation of peptide antigen via MHC class II

peptide antigen assembly with MHC class Ib protein complex
IAO_0000115: The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
type: Class
subclass of: part-of-parent-2398
subclass of: part-of-parent-2428
subclass of: peptide antigen assembly with MHC protein complex

lipid antigen assembly with MHC class Ib protein complex
IAO_0000115: The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family.
type: Class
subclass of: part-of-parent-2398
subclass of: part-of-parent-48003
subclass of: GO_0065005

lipid antigen transport
IAO_0000115: The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
type: Class
subclass of: part-of-parent-48003
subclass of: GO_0006869

antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
has exact synonym: peptide antigen processing and presentation via MHC class II
type: Class
subclass of: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: GO_0048002

proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation.
type: Class
subclass of: part-of-parent-48002
subclass of: GO_0051603

proteasomal proteolysis associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation.
type: Class
subclass of: proteolysis associated with antigen processing and presentation

proteolysis within endoplasmic reticulum associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation.
has exact synonym: ER proteolysis associated with antigen processing and presentation
has exact synonym: endoplasmic reticulum proteolysis associated with antigen processing and presentation
has exact synonym: proteolysis within ER associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation

proteolysis within endosome associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation.
has exact synonym: endosomal proteolysis associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation

proteolysis within lysosome associated with antigen processing and presentation
IAO_0000115: The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation.
has exact synonym: lysosomal proteolysis associated with antigen processing and presentation
type: Class
subclass of: proteolysis associated with antigen processing and presentation

peptide antigen assembly with MHC protein complex
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC protein complex.
type: Class
subclass of: part-of-parent-2396
subclass of: part-of-parent-48002
subclass of: GO_0034622

peptide antigen assembly with MHC class I protein complex
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: part-of-parent-2397
subclass of: part-of-parent-2474

peptide antigen assembly with MHC class II protein complex
IAO_0000115: The binding of a peptide to the antigen binding groove of an MHC class II protein complex.
type: Class
subclass of: peptide antigen assembly with MHC protein complex
subclass of: part-of-parent-2399
subclass of: part-of-parent-2495

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.
has exact synonym: peptide or polysaccharide antigen processing and presentation of via MHC class II
type: Class
subclass of: GO_0019882

antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex.
has exact synonym: polysaccharide antigen processing and presentation via MHC class II
type: Class
subclass of: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

tolerance induction
IAO_0000115: A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
type: Class
subclass of: immune system process
subclass of: part-of-parent-2520

central tolerance induction
IAO_0000115: Tolerance induction in the central lymphoid organs: the thymus and bone marrow.
type: Class
subclass of: tolerance induction

central tolerance induction to self antigen
IAO_0000115: Tolerance induction in the central lymphoid organs directed at self antigens.
type: Class
subclass of: central tolerance induction
subclass of: tolerance induction to self antigen

central B cell tolerance induction
IAO_0000115: Tolerance induction of B cells in the bone marrow.
has exact synonym: central B lymphocyte tolerance induction
has exact synonym: central B-cell tolerance induction
has exact synonym: central B-lymphocyte tolerance induction
type: Class
subclass of: central tolerance induction
subclass of: B cell tolerance induction

central B cell receptor editing
IAO_0000115: Receptor editing occurring in B cells in the bone marrow.
has exact synonym: central B lymphocyte receptor editing
has exact synonym: central B-cell receptor editing
has exact synonym: central B-lymphocyte receptor editing
type: Class
subclass of: B cell receptor editing

central T cell tolerance induction
IAO_0000115: Tolerance induction of T cells in the thymus.
has exact synonym: central T lymphocyte tolerance induction
has exact synonym: central T-cell tolerance induction
has exact synonym: central T-lymphocyte tolerance induction
type: Class
subclass of: central tolerance induction
subclass of: T cell tolerance induction

tolerance induction to self antigen
IAO_0000115: Tolerance induction directed at self antigens.
type: Class
subclass of: tolerance induction

B cell tolerance induction
IAO_0000115: A process involving any mechanism for tolerance induction in B cells.
has exact synonym: B lymphocyte tolerance induction
has exact synonym: B-cell tolerance induction
has exact synonym: B-lymphocyte tolerance induction
type: Class
subclass of: tolerance induction

B cell anergy
IAO_0000115: Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction.
has exact synonym: B lymphocyte anergy
has exact synonym: B-cell anergy
has exact synonym: B-lymphocyte anergy
type: Class
subclass of: lymphocyte anergy
subclass of: B cell tolerance induction

B cell deletion
IAO_0000115: The apoptotic death of B cells which is part of B cell tolerance induction.
has exact synonym: B lymphocyte deletion
has exact synonym: B-cell deletion
has exact synonym: B-lymphocyte deletion
type: Class
subclass of: B cell apoptotic process
subclass of: part-of-parent-2514
subclass of: GO_1902742

T cell tolerance induction
IAO_0000115: A process involving any mechanism for tolerance induction in T cells.
has exact synonym: T lymphocyte tolerance induction
has exact synonym: T-cell tolerance induction
has exact synonym: T-lymphocyte tolerance induction
type: Class
subclass of: tolerance induction

lymphocyte chemotaxis across high endothelial venule
IAO_0000115: The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus.
type: Class
subclass of: GO_0048247

natural killer cell tolerance induction
IAO_0000115: Tolerance induction of natural killer cells.
has exact synonym: NK cell tolerance induction
type: Class
subclass of: tolerance induction

immune system development
IAO_0000115: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
type: Class
subclass of: immune system process
subclass of: GO_0048731

leukocyte differentiation
IAO_0000115: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
has exact synonym: immune cell differentiation
has exact synonym: leucocyte differentiation
type: Class
subclass of: part-of-parent-30097
subclass of: GO_0030154

leukocyte migration involved in immune response
IAO_0000115: The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.
has exact synonym: immune cell migration during immune response
has exact synonym: immune cell trafficking during immune response
has exact synonym: leucocyte migration during immune response
has exact synonym: leucocyte trafficking during immune response
has exact synonym: leukocyte trafficking during immune response
type: Class
subclass of: immune effector process
subclass of: part-of-parent-6955
subclass of: GO_0050900

leukocyte migration involved in inflammatory response
IAO_0000115: The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
has related synonym: immune cell migration during inflammatory response
has related synonym: immune cell trafficking during inflammatory response
has related synonym: leucocyte migration during inflammatory response
has related synonym: leucocyte trafficking during inflammatory response
has related synonym: leukocyte migration during inflammatory response
has related synonym: leukocyte trafficking during inflammatory response
type: Class
subclass of: part-of-parent-6954
subclass of: GO_0050900

hypersensitivity
IAO_0000115: An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
has related synonym: hypersensitivity response
type: Class
subclass of: acute inflammatory response to antigenic stimulus

acute inflammatory response to non-antigenic stimulus
IAO_0000115: An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma.
type: Class
subclass of: acute inflammatory response

acute inflammatory response
IAO_0000115: Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
type: Class
subclass of: GO_0006954

vasodilation involved in acute inflammatory response
IAO_0000115: An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response.
has related synonym: vasodilation during acute inflammatory response
type: Class
subclass of: part-of-parent-2526
subclass of: GO_0042311

regulation of vascular permeability involved in acute inflammatory response
IAO_0000115: Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.
has related synonym: regulation of vascular permeability during acute inflammatory response
type: Class
subclass of: part-of-parent-2526
subclass of: GO_0043114

regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
type: Class
subclass of: regulation of kinin cascade

regulation of systemic arterial blood pressure involved in acute-phase response
IAO_0000115: Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.
has related synonym: blood pressure regulation during acute phase response
has related synonym: regulation of systemic arterial blood pressure during acute phase response
type: Class
subclass of: part-of-parent-6953
subclass of: regulation of systemic arterial blood pressure

regulation of heart contraction involved in acute-phase response
IAO_0000115: Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.
has related synonym: regulation of cardiac contraction during acute phase response
has related synonym: regulation of heart contraction during acute phase response
type: Class
subclass of: part-of-parent-6953
subclass of: GO_0008016

production of molecular mediator involved in inflammatory response
IAO_0000115: The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.
has related synonym: production of cellular mediator of acute inflammation
has related synonym: production of molecular mediator involved in acute inflammatory response
type: Class
subclass of: part-of-parent-6954
subclass of: GO_0032501

lysosomal enzyme secretion involved in inflammatory response
IAO_0000115: The regulated release of lysosomal enzymes by a cell as part of an inflammatory response.
has exact synonym: secretion of lysosomal enzymes involved in inflammatory response
has related synonym: lysosomal enzyme secretion involved in acute inflammatory response
has related synonym: secretion of lysosomal enzymes involved in acute inflammatory response
type: Class
subclass of: part-of-parent-2393
subclass of: part-of-parent-6954
subclass of: GO_0033299

cytokine production involved in inflammatory response
IAO_0000115: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: cytokine production involved in acute inflammatory response
type: Class
subclass of: cytokine production
subclass of: production of molecular mediator involved in inflammatory response
subclass of: part-of-parent-6954

platelet activating factor secretion involved in inflammatory response
IAO_0000115: The regulated release of platelet activating factor by a cell as part of an inflammatory response.
has related synonym: platelet activating factor secretion involved in acute inflammatory response
type: Class
subclass of: platelet activating factor secretion
subclass of: part-of-parent-2391
subclass of: part-of-parent-6954

respiratory burst involved in inflammatory response
IAO_0000115: A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.
has related synonym: oxidative burst during acute inflammatory response
has related synonym: production of reactive oxygen species during acute inflammatory response
has related synonym: respiratory burst involved in acute inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response
subclass of: part-of-parent-6954
subclass of: respiratory burst involved in defense response

nitric oxide production involved in inflammatory response
IAO_0000115: The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has exact synonym: production of nitric oxide involved in inflammatory response
has related synonym: nitric oxide production involved in acute inflammatory response
has related synonym: production of nitric oxide involved in acute inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response

arachidonic acid metabolite production involved in inflammatory response
IAO_0000115: The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels.
has exact synonym: production of arachidonic acid metabolites involved in inflammatory response
has related synonym: arachidonic acid metabolite production involved in acute inflammatory response
has related synonym: production of arachidonic acid metabolites involved in acute inflammatory response
type: Class
subclass of: production of molecular mediator involved in inflammatory response

prostaglandin production involved in inflammatory response
IAO_0000115: The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: prostaglandin production involved in acute inflammatory response
type: Class
subclass of: arachidonic acid metabolite production involved in inflammatory response

leukotriene production involved in inflammatory response
IAO_0000115: The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has related synonym: leukotriene production involved in acute inflammatory response
type: Class
subclass of: arachidonic acid metabolite production involved in inflammatory response

activation of plasma proteins involved in acute inflammatory response
IAO_0000115: Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
type: Class
subclass of: part-of-parent-2526
subclass of: GO_0016485

Factor XII activation
IAO_0000115: Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
has exact synonym: Hageman factor activation
type: Class
subclass of: part-of-parent-2353
subclass of: positive regulation of acute inflammatory response
subclass of: GO_0010954

activation of blood coagulation via clotting cascade
IAO_0000115: Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.
has exact synonym: activation of clotting cascade
type: Class
subclass of: part-of-parent-2526
subclass of: GO_0030194

chronic inflammatory response
IAO_0000115: Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.
type: Class
subclass of: GO_0006954

chronic inflammatory response to non-antigenic stimulus
IAO_0000115: A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma.
type: Class
subclass of: chronic inflammatory response

negative regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: down regulation of tissue kallikrein-kinin cascade
has exact synonym: down-regulation of tissue kallikrein-kinin cascade
has exact synonym: downregulation of tissue kallikrein-kinin cascade
has exact synonym: negative regulation of glandular kallikrein-kinin cascade
has related synonym: inhibition of tissue kallikrein-kinin cascade
type: Class
subclass of: negative regulation of kinin cascade
subclass of: regulation of tissue kallikrein-kinin cascade

positive regulation of tissue kallikrein-kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
has exact synonym: positive regulation of glandular kallikrein-kinin cascade
has exact synonym: up regulation of tissue kallikrein-kinin cascade
has exact synonym: up-regulation of tissue kallikrein-kinin cascade
has exact synonym: upregulation of tissue kallikrein-kinin cascade
has related synonym: activation of tissue kallikrein-kinin cascade
has related synonym: stimulation of tissue kallikrein-kinin cascade
type: Class
subclass of: positive regulation of kinin cascade
subclass of: regulation of tissue kallikrein-kinin cascade

monocyte chemotaxis
IAO_0000115: The movement of a monocyte in response to an external stimulus.
type: Class
subclass of: GO_0030595
subclass of: GO_0071674
subclass of: GO_0097529

negative regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has exact synonym: down regulation of plasma kallikrein-kinin cascade
has exact synonym: down-regulation of plasma kallikrein-kinin cascade
has exact synonym: downregulation of plasma kallikrein-kinin cascade
has related synonym: inhibition of plasma kallikrein-kinin cascade
type: Class
subclass of: negative regulation of kinin cascade
subclass of: regulation of plasma kallikrein-kinin cascade

positive regulation of plasma kallikrein-kinin cascade
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.
has exact synonym: up regulation of plasma kallikrein-kinin cascade
has exact synonym: up-regulation of plasma kallikrein-kinin cascade
has exact synonym: upregulation of plasma kallikrein-kinin cascade
has related synonym: activation of plasma kallikrein-kinin cascade
has related synonym: stimulation of plasma kallikrein-kinin cascade
type: Class
subclass of: positive regulation of kinin cascade
subclass of: regulation of plasma kallikrein-kinin cascade

mast cell chemotaxis
IAO_0000115: The movement of a mast cell in response to an external stimulus.
type: Class
subclass of: GO_0030595
subclass of: GO_0097531

serotonin secretion by mast cell
IAO_0000115: The regulated release of serotonin by a mast cell or group of mast cells.
has related synonym: serotonin release by mast cell
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: part-of-parent-43303
subclass of: GO_0051649
subclass of: GO_0140029

histamine secretion by mast cell
IAO_0000115: The regulated release of histamine by a mast cell or group of mast cells.
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: part-of-parent-43303
subclass of: GO_0051649
subclass of: GO_0140029

serotonin secretion by platelet
IAO_0000115: The regulated release of serotonin by a platelet or group of platelets.
has related synonym: serotonin release by platelet
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: part-of-parent-2576
subclass of: GO_0051649
subclass of: GO_0140029

histamine secretion by platelet
IAO_0000115: The regulated release of histamine by a platelet or group of platelets.
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: part-of-parent-2576
subclass of: GO_0051649
subclass of: GO_0140029

serotonin secretion by basophil
IAO_0000115: The regulated release of serotonin by a basophil or group of basophils.
has related synonym: serotonin release by basophil
type: Class
subclass of: serotonin secretion involved in inflammatory response
subclass of: part-of-parent-2561
subclass of: GO_0051649
subclass of: GO_0140029

histamine secretion by basophil
IAO_0000115: The regulated release of histamine by a basophil or group of basophils.
type: Class
subclass of: histamine secretion involved in inflammatory response
subclass of: part-of-parent-2561
subclass of: GO_0051649
subclass of: GO_0140029

type I hypersensitivity mediated by mast cells
IAO_0000115: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
type: Class
subclass of: mast cell mediated immunity
subclass of: GO_0016068

type I hypersensitivity mediated by basophils
IAO_0000115: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
type: Class
subclass of: basophil mediated immunity
subclass of: GO_0016068

basophil mediated immunity
IAO_0000115: Any process involved in the carrying out of an immune response by a basophil.
type: Class
subclass of: myeloid leukocyte mediated immunity

basophil degranulation
IAO_0000115: The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil.
type: Class
subclass of: basophil activation involved in immune response
subclass of: part-of-parent-2560
subclass of: GO_0043299

somatic diversification of immune receptors via germline recombination within a single locus
IAO_0000115: The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.
type: Class
subclass of: somatic diversification of immune receptors
subclass of: GO_0016444

somatic diversification of immune receptors via alternate splicing
IAO_0000115: The process in which immune receptor genes are diversified through alternate splicing.
type: Class
subclass of: somatic diversification of immune receptors

alternate splicing of immunoglobulin genes
IAO_0000115: The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons.
has exact synonym: alternate splicing of antibody genes
type: Class
subclass of: somatic diversification of immune receptors via alternate splicing
subclass of: GO_0016445

somatic diversification of immune receptors via gene conversion
IAO_0000115: The process in which immune receptor genes are diversified through gene conversion.
type: Class
subclass of: somatic diversification of immune receptors
subclass of: GO_0016444

somatic diversification of immune receptors via somatic mutation
IAO_0000115: The process in which immune receptor genes are diversified through somatic mutation.
type: Class
subclass of: somatic diversification of immune receptors

somatic diversification of FREP-based immune receptors
IAO_0000115: The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails.
type: Class
subclass of: somatic diversification of immune receptors

somatic diversification of T cell receptor genes
IAO_0000115: The somatic process that results in the generation of sequence diversity of T cell receptor genes.
has exact synonym: somatic diversification of TCR genes
type: Class
subclass of: somatic diversification of immune receptors
subclass of: part-of-parent-30217

somatic diversification of immune receptors by N region addition
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene.
type: Class
subclass of: somatic diversification of immune receptors

somatic diversification of immunoglobulin genes by N region addition
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions.
has exact synonym: somatic diversification of antibody genes by N region addition
type: Class
subclass of: somatic diversification of immune receptors by N region addition
subclass of: part-of-parent-16447
subclass of: GO_0016445

somatic diversification of T cell receptor genes by N region addition
IAO_0000115: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene.
has exact synonym: somatic diversification of TCR genes by N region addition
type: Class
subclass of: somatic diversification of T cell receptor genes
subclass of: somatic diversification of immune receptors by N region addition
subclass of: part-of-parent-2681

pro-T cell differentiation
IAO_0000115: The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.
has exact synonym: pro-T lymphocyte differentiation
type: Class
subclass of: lymphoid progenitor cell differentiation
subclass of: part-of-parent-30217

myeloid leukocyte differentiation
IAO_0000115: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
has exact synonym: myeloid leucocyte differentiation
type: Class
subclass of: leukocyte differentiation
subclass of: GO_0030099

thrombocyte differentiation
IAO_0000115: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
type: Class
subclass of: GO_0030099

basophil chemotaxis
IAO_0000115: The movement of a basophil in response to an external stimulus.
type: Class
subclass of: GO_0071621

platelet degranulation
IAO_0000115: The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
has exact synonym: platelet exocytosis
type: Class
subclass of: GO_0045055
subclass of: GO_0051649

regulation of antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation.
type: Class
subclass of: regulation of immune system process

negative regulation of antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.
has exact synonym: down regulation of antigen processing and presentation
has exact synonym: down-regulation of antigen processing and presentation
has exact synonym: downregulation of antigen processing and presentation
has related synonym: inhibition of antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: negative regulation of immune system process

positive regulation of antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.
has exact synonym: up regulation of antigen processing and presentation
has exact synonym: up-regulation of antigen processing and presentation
has exact synonym: upregulation of antigen processing and presentation
has related synonym: activation of antigen processing and presentation
has related synonym: stimulation of antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: positive regulation of immune system process

regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
has related synonym: inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
has exact synonym: positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II
has exact synonym: up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has related synonym: activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
has related synonym: stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: regulation of peptide antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen
has exact synonym: downregulation of antigen processing and presentation of peptide antigen
has exact synonym: negative regulation of peptide antigen processing and presentation
has related synonym: inhibition of antigen processing and presentation of peptide antigen
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide antigen

positive regulation of antigen processing and presentation of peptide antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen.
has exact synonym: positive regulation of peptide antigen processing and presentation
has exact synonym: up regulation of antigen processing and presentation of peptide antigen
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen
has exact synonym: upregulation of antigen processing and presentation of peptide antigen
has related synonym: activation of antigen processing and presentation of peptide antigen
has related synonym: stimulation of antigen processing and presentation of peptide antigen
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation of peptide antigen

regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class II
type: Class
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of peptide antigen

negative regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class II
has related synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class II
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class II

positive regulation of antigen processing and presentation of peptide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class II
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class II
has related synonym: activation of antigen processing and presentation of peptide antigen via MHC class II
has related synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class II
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class I
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen

negative regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class I
has related synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class I
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class I

positive regulation of antigen processing and presentation of peptide antigen via MHC class I
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class I
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class I
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class I
has related synonym: activation of antigen processing and presentation of peptide antigen via MHC class I
has related synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class I
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class I

regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has exact synonym: down regulation of antigen processing and presentation via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation via MHC class Ib
has exact synonym: downregulation of antigen processing and presentation via MHC class Ib
has related synonym: inhibition of antigen processing and presentation via MHC class Ib
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation via MHC class Ib

positive regulation of antigen processing and presentation via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.
has exact synonym: up regulation of antigen processing and presentation via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation via MHC class Ib
has related synonym: activation of antigen processing and presentation via MHC class Ib
has related synonym: stimulation of antigen processing and presentation via MHC class Ib
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of antigen processing and presentation via MHC class Ib

regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: regulation of peptide antigen processing and presentation via MHC class Ib
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: down regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: downregulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: negative regulation of peptide antigen processing and presentation via MHC class Ib
has related synonym: inhibition of antigen processing and presentation of peptide antigen via MHC class Ib
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: negative regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class Ib

positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.
has exact synonym: positive regulation of peptide antigen processing and presentation via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation of peptide antigen via MHC class Ib
has related synonym: activation of antigen processing and presentation of peptide antigen via MHC class Ib
has related synonym: stimulation of antigen processing and presentation of peptide antigen via MHC class Ib
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: positive regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of peptide antigen via MHC class Ib

regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: regulation of lipid antigen processing and presentation via MHC class Ib
type: Class
subclass of: regulation of antigen processing and presentation via MHC class Ib

negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: down regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: downregulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: negative regulation of lipid antigen processing and presentation via MHC class Ib
has related synonym: inhibition of antigen processing and presentation of lipid antigen via MHC class Ib
type: Class
subclass of: negative regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of lipid antigen via MHC class Ib

positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.
has exact synonym: positive regulation of lipid antigen processing and presentation via MHC class Ib
has exact synonym: up regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib
has exact synonym: upregulation of antigen processing and presentation of lipid antigen via MHC class Ib
has related synonym: activation of antigen processing and presentation of lipid antigen via MHC class Ib
has related synonym: stimulation of antigen processing and presentation of lipid antigen via MHC class Ib
type: Class
subclass of: positive regulation of antigen processing and presentation via MHC class Ib
subclass of: regulation of antigen processing and presentation of lipid antigen via MHC class Ib

regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: regulation of polysaccharide antigen processing and presentation via MHC class II
type: Class
subclass of: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: negative regulation of polysaccharide antigen processing and presentation via MHC class II
has related synonym: inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.
has exact synonym: positive regulation of polysaccharide antigen processing and presentation via MHC class II
has exact synonym: up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has exact synonym: upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II
has related synonym: activation of antigen processing and presentation of polysaccharide antigen via MHC class II
has related synonym: stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
subclass of: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has exact synonym: down regulation of dendritic cell antigen processing and presentation
has exact synonym: down-regulation of dendritic cell antigen processing and presentation
has exact synonym: downregulation of dendritic cell antigen processing and presentation
has related synonym: inhibition of dendritic cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of dendritic cell antigen processing and presentation

positive regulation of dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.
has exact synonym: up regulation of dendritic cell antigen processing and presentation
has exact synonym: up-regulation of dendritic cell antigen processing and presentation
has exact synonym: upregulation of dendritic cell antigen processing and presentation
has related synonym: activation of dendritic cell antigen processing and presentation
has related synonym: stimulation of dendritic cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of dendritic cell antigen processing and presentation

regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
type: Class
subclass of: regulation of dendritic cell antigen processing and presentation

negative regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has exact synonym: down regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: down-regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: downregulation of myeloid dendritic cell antigen processing and presentation
has related synonym: inhibition of myeloid dendritic cell antigen processing and presentation
type: Class
subclass of: negative regulation of dendritic cell antigen processing and presentation
subclass of: regulation of myeloid dendritic cell antigen processing and presentation

positive regulation of myeloid dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.
has exact synonym: up regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: up-regulation of myeloid dendritic cell antigen processing and presentation
has exact synonym: upregulation of myeloid dendritic cell antigen processing and presentation
has related synonym: activation of myeloid dendritic cell antigen processing and presentation
has related synonym: stimulation of myeloid dendritic cell antigen processing and presentation
type: Class
subclass of: positive regulation of dendritic cell antigen processing and presentation
subclass of: regulation of myeloid dendritic cell antigen processing and presentation

regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
type: Class
subclass of: regulation of dendritic cell antigen processing and presentation

negative regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has exact synonym: down regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: down-regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: downregulation of plasmacytoid dendritic cell antigen processing and presentation
has related synonym: inhibition of plasmacytoid dendritic cell antigen processing and presentation
type: Class
subclass of: negative regulation of dendritic cell antigen processing and presentation
subclass of: regulation of plasmacytoid dendritic cell antigen processing and presentation

positive regulation of plasmacytoid dendritic cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.
has exact synonym: up regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: up-regulation of plasmacytoid dendritic cell antigen processing and presentation
has exact synonym: upregulation of plasmacytoid dendritic cell antigen processing and presentation
has related synonym: activation of plasmacytoid dendritic cell antigen processing and presentation
has related synonym: stimulation of plasmacytoid dendritic cell antigen processing and presentation
type: Class
subclass of: positive regulation of dendritic cell antigen processing and presentation
subclass of: regulation of plasmacytoid dendritic cell antigen processing and presentation

regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.
has exact synonym: down regulation of monocyte antigen processing and presentation
has exact synonym: down-regulation of monocyte antigen processing and presentation
has exact synonym: downregulation of monocyte antigen processing and presentation
has related synonym: inhibition of monocyte antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of monocyte antigen processing and presentation

positive regulation of monocyte antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.
has exact synonym: up regulation of monocyte antigen processing and presentation
has exact synonym: up-regulation of monocyte antigen processing and presentation
has exact synonym: upregulation of monocyte antigen processing and presentation
has related synonym: activation of monocyte antigen processing and presentation
has related synonym: stimulation of monocyte antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of monocyte antigen processing and presentation

regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.
has exact synonym: down regulation of macrophage antigen processing and presentation
has exact synonym: down-regulation of macrophage antigen processing and presentation
has exact synonym: downregulation of macrophage antigen processing and presentation
has related synonym: inhibition of macrophage antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of macrophage antigen processing and presentation

positive regulation of macrophage antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.
has exact synonym: up regulation of macrophage antigen processing and presentation
has exact synonym: up-regulation of macrophage antigen processing and presentation
has exact synonym: upregulation of macrophage antigen processing and presentation
has related synonym: activation of macrophage antigen processing and presentation
has related synonym: stimulation of macrophage antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of macrophage antigen processing and presentation

regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
type: Class
subclass of: regulation of antigen processing and presentation

negative regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has exact synonym: down regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: down-regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: downregulation of non-professional antigen presenting cell antigen processing and presentation
has related synonym: inhibition of non-professional antigen presenting cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of non-professional antigen presenting cell antigen processing and presentation

positive regulation of non-professional antigen presenting cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.
has exact synonym: up regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: up-regulation of non-professional antigen presenting cell antigen processing and presentation
has exact synonym: upregulation of non-professional antigen presenting cell antigen processing and presentation
has related synonym: activation of non-professional antigen presenting cell antigen processing and presentation
has related synonym: stimulation of non-professional antigen presenting cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of non-professional antigen presenting cell antigen processing and presentation

regulation of B cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: regulation of B lymphocyte antigen processing and presentation
has exact synonym: regulation of B-cell antigen processing and presentation
has exact synonym: regulation of B-lymphocyte antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: regulation of B cell mediated immunity

negative regulation of B cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: down regulation of B cell antigen processing and presentation
has exact synonym: down-regulation of B cell antigen processing and presentation
has exact synonym: downregulation of B cell antigen processing and presentation
has exact synonym: negative regulation of B lymphocyte antigen processing and presentation
has exact synonym: negative regulation of B-cell antigen processing and presentation
has exact synonym: negative regulation of B-lymphocyte antigen processing and presentation
has related synonym: inhibition of B cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of B cell antigen processing and presentation
subclass of: negative regulation of B cell mediated immunity

positive regulation of B cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation.
has exact synonym: positive regulation of B lymphocyte antigen processing and presentation
has exact synonym: positive regulation of B-cell antigen processing and presentation
has exact synonym: positive regulation of B-lymphocyte antigen processing and presentation
has exact synonym: up regulation of B cell antigen processing and presentation
has exact synonym: up-regulation of B cell antigen processing and presentation
has exact synonym: upregulation of B cell antigen processing and presentation
has related synonym: activation of B cell antigen processing and presentation
has related synonym: stimulation of B cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of B cell antigen processing and presentation
subclass of: positive regulation of B cell mediated immunity

regulation of T cell antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: regulation of T lymphocyte antigen processing and presentation
has exact synonym: regulation of T-cell antigen processing and presentation
has exact synonym: regulation of T-lymphocyte antigen processing and presentation
type: Class
subclass of: regulation of antigen processing and presentation
subclass of: regulation of T cell mediated immunity

negative regulation of T cell antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: down regulation of T cell antigen processing and presentation
has exact synonym: down-regulation of T cell antigen processing and presentation
has exact synonym: downregulation of T cell antigen processing and presentation
has exact synonym: negative regulation of T lymphocyte antigen processing and presentation
has exact synonym: negative regulation of T-cell antigen processing and presentation
has exact synonym: negative regulation of T-lymphocyte antigen processing and presentation
has related synonym: inhibition of T cell antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation
subclass of: regulation of T cell antigen processing and presentation
subclass of: negative regulation of T cell mediated immunity

positive regulation of T cell antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.
has exact synonym: positive regulation of T lymphocyte antigen processing and presentation
has exact synonym: positive regulation of T-cell antigen processing and presentation
has exact synonym: positive regulation of T-lymphocyte antigen processing and presentation
has exact synonym: up regulation of T cell antigen processing and presentation
has exact synonym: up-regulation of T cell antigen processing and presentation
has exact synonym: upregulation of T cell antigen processing and presentation
has related synonym: activation of T cell antigen processing and presentation
has related synonym: stimulation of T cell antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation
subclass of: regulation of T cell antigen processing and presentation
subclass of: positive regulation of T cell mediated immunity

regulation of proteolysis associated with antigen processing and presentation
IAO_0000115: Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
type: Class
subclass of: regulation of antigen processing and presentation of peptide antigen
subclass of: GO_1903050

negative regulation of proteolysis associated with antigen processing and presentation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has exact synonym: down regulation of proteolysis associated with antigen processing and presentation
has exact synonym: down-regulation of proteolysis associated with antigen processing and presentation
has exact synonym: downregulation of proteolysis associated with antigen processing and presentation
has related synonym: inhibition of proteolysis associated with antigen processing and presentation
type: Class
subclass of: negative regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of proteolysis associated with antigen processing and presentation
subclass of: GO_1903051

positive regulation of proteolysis associated with antigen processing and presentation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.
has exact synonym: up regulation of proteolysis associated with antigen processing and presentation
has exact synonym: up-regulation of proteolysis associated with antigen processing and presentation
has exact synonym: upregulation of proteolysis associated with antigen processing and presentation
has related synonym: activation of proteolysis associated with antigen processing and presentation
has related synonym: stimulation of proteolysis associated with antigen processing and presentation
type: Class
subclass of: positive regulation of antigen processing and presentation of peptide antigen
subclass of: regulation of proteolysis associated with antigen processing and presentation
subclass of: GO_1903052

regulation of granuloma formation
IAO_0000115: Any process that modulates the frequency, rate, or extent of granuloma formation.
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: regulation of immune effector process

negative regulation of granuloma formation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation.
has exact synonym: down regulation of granuloma formation
has exact synonym: down-regulation of granuloma formation
has exact synonym: downregulation of granuloma formation
has related synonym: inhibition of granuloma formation
type: Class
subclass of: regulation of granuloma formation
subclass of: negative regulation of chronic inflammatory response
subclass of: negative regulation of immune effector process

positive regulation of granuloma formation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of granuloma formation.
has exact synonym: up regulation of granuloma formation
has exact synonym: up-regulation of granuloma formation
has exact synonym: upregulation of granuloma formation
has related synonym: activation of granuloma formation
has related synonym: stimulation of granuloma formation
type: Class
subclass of: regulation of granuloma formation
subclass of: positive regulation of chronic inflammatory response
subclass of: positive regulation of immune effector process

regulation of germinal center formation
IAO_0000115: Any process that modulates the frequency, rate, or extent of germinal center formation.
type: Class
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0022603

negative regulation of germinal center formation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.
has exact synonym: down regulation of germinal center formation
has exact synonym: down-regulation of germinal center formation
has exact synonym: downregulation of germinal center formation
has related synonym: inhibition of germinal center formation
type: Class
subclass of: regulation of germinal center formation
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0051093

positive regulation of germinal center formation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of germinal center formation.
has exact synonym: up regulation of germinal center formation
has exact synonym: up-regulation of germinal center formation
has exact synonym: upregulation of germinal center formation
has related synonym: activation of germinal center formation
has related synonym: stimulation of germinal center formation
type: Class
subclass of: regulation of germinal center formation
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: GO_0051094

regulation of immunoglobulin production
IAO_0000115: Any process that modulates the frequency, rate, or extent of immunoglobulin production.
type: Class
subclass of: regulation of production of molecular mediator of immune response

negative regulation of immunoglobulin production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.
has exact synonym: down regulation of immunoglobulin production
has exact synonym: down-regulation of immunoglobulin production
has exact synonym: downregulation of immunoglobulin production
has related synonym: inhibition of immunoglobulin production
type: Class
subclass of: regulation of immunoglobulin production
subclass of: negative regulation of production of molecular mediator of immune response

positive regulation of immunoglobulin production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
has exact synonym: up regulation of immunoglobulin production
has exact synonym: up-regulation of immunoglobulin production
has exact synonym: upregulation of immunoglobulin production
has related synonym: activation of immunoglobulin production
has related synonym: stimulation of immunoglobulin production
type: Class
subclass of: regulation of immunoglobulin production
subclass of: positive regulation of production of molecular mediator of immune response

regulation of immunoglobulin biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis.
type: Class
subclass of: regulation of immunoglobulin production
subclass of: GO_0010556

negative regulation of immunoglobulin biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis.
has exact synonym: down regulation of immunoglobulin biosynthetic process
has exact synonym: down-regulation of immunoglobulin biosynthetic process
has exact synonym: downregulation of immunoglobulin biosynthetic process
has related synonym: inhibition of immunoglobulin biosynthetic process
type: Class
subclass of: negative regulation of immunoglobulin production
subclass of: regulation of immunoglobulin biosynthetic process
subclass of: GO_0010558

positive regulation of immunoglobulin biosynthetic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis.
has exact synonym: up regulation of immunoglobulin biosynthetic process
has exact synonym: up-regulation of immunoglobulin biosynthetic process
has exact synonym: upregulation of immunoglobulin biosynthetic process
has related synonym: activation of immunoglobulin biosynthetic process
has related synonym: stimulation of immunoglobulin biosynthetic process
type: Class
subclass of: positive regulation of immunoglobulin production
subclass of: regulation of immunoglobulin biosynthetic process
subclass of: GO_0010557

regulation of tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction.
type: Class
subclass of: regulation of immune system process
subclass of: GO_2000026

negative regulation of tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.
has exact synonym: down regulation of tolerance induction
has exact synonym: down-regulation of tolerance induction
has exact synonym: downregulation of tolerance induction
has related synonym: inhibition of tolerance induction
type: Class
subclass of: regulation of tolerance induction
subclass of: negative regulation of immune system process
subclass of: GO_0051093
subclass of: GO_0051241

positive regulation of tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction.
has exact synonym: up regulation of tolerance induction
has exact synonym: up-regulation of tolerance induction
has exact synonym: upregulation of tolerance induction
has related synonym: activation of tolerance induction
has related synonym: stimulation of tolerance induction
type: Class
subclass of: regulation of tolerance induction
subclass of: positive regulation of immune system process
subclass of: GO_0051094
subclass of: GO_0051240

regulation of central tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of central tolerance induction.
type: Class
subclass of: regulation of tolerance induction

negative regulation of central tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction.
has exact synonym: down regulation of central tolerance induction
has exact synonym: down-regulation of central tolerance induction
has exact synonym: downregulation of central tolerance induction
has related synonym: inhibition of central tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of central tolerance induction

positive regulation of central tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central tolerance induction.
has exact synonym: up regulation of central tolerance induction
has exact synonym: up-regulation of central tolerance induction
has exact synonym: upregulation of central tolerance induction
has related synonym: activation of central tolerance induction
has related synonym: stimulation of central tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of central tolerance induction

regulation of tolerance induction to self antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen.
type: Class
subclass of: regulation of tolerance induction

negative regulation of tolerance induction to self antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen.
has exact synonym: down regulation of tolerance induction to self antigen
has exact synonym: down-regulation of tolerance induction to self antigen
has exact synonym: downregulation of tolerance induction to self antigen
has related synonym: inhibition of tolerance induction to self antigen
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of tolerance induction to self antigen

positive regulation of tolerance induction to self antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen.
has exact synonym: up regulation of tolerance induction to self antigen
has exact synonym: up-regulation of tolerance induction to self antigen
has exact synonym: upregulation of tolerance induction to self antigen
has related synonym: activation of tolerance induction to self antigen
has related synonym: stimulation of tolerance induction to self antigen
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of tolerance induction to self antigen

regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: regulation of immune response-dependent tolerance induction
type: Class
subclass of: regulation of tolerance induction
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

negative regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: down regulation of tolerance induction dependent upon immune response
has exact synonym: down-regulation of tolerance induction dependent upon immune response
has exact synonym: downregulation of tolerance induction dependent upon immune response
has exact synonym: negative regulation of immune response-dependent tolerance induction
has related synonym: inhibition of tolerance induction dependent upon immune response
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

positive regulation of tolerance induction dependent upon immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.
has exact synonym: positive regulation of immune response-dependent tolerance induction
has exact synonym: up regulation of tolerance induction dependent upon immune response
has exact synonym: up-regulation of tolerance induction dependent upon immune response
has exact synonym: upregulation of tolerance induction dependent upon immune response
has related synonym: activation of tolerance induction dependent upon immune response
has related synonym: stimulation of tolerance induction dependent upon immune response
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of tolerance induction dependent upon immune response
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen.
type: Class
subclass of: regulation of tolerance induction dependent upon immune response

negative regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen.
has exact synonym: down regulation of tolerance induction to nonself antigen
has exact synonym: down-regulation of tolerance induction to nonself antigen
has exact synonym: downregulation of tolerance induction to nonself antigen
has related synonym: inhibition of tolerance induction to nonself antigen
type: Class
subclass of: negative regulation of tolerance induction dependent upon immune response
subclass of: regulation of tolerance induction to nonself antigen

positive regulation of tolerance induction to nonself antigen
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.
has exact synonym: up regulation of tolerance induction to nonself antigen
has exact synonym: up-regulation of tolerance induction to nonself antigen
has exact synonym: upregulation of tolerance induction to nonself antigen
has related synonym: activation of tolerance induction to nonself antigen
has related synonym: stimulation of tolerance induction to nonself antigen
type: Class
subclass of: positive regulation of tolerance induction dependent upon immune response
subclass of: regulation of tolerance induction to nonself antigen

regulation of peripheral tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.
type: Class
subclass of: regulation of tolerance induction dependent upon immune response

negative regulation of peripheral tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.
has exact synonym: down regulation of peripheral tolerance induction
has exact synonym: down-regulation of peripheral tolerance induction
has exact synonym: downregulation of peripheral tolerance induction
has related synonym: inhibition of peripheral tolerance induction
type: Class
subclass of: negative regulation of tolerance induction dependent upon immune response
subclass of: regulation of peripheral tolerance induction

positive regulation of peripheral tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.
has exact synonym: up regulation of peripheral tolerance induction
has exact synonym: up-regulation of peripheral tolerance induction
has exact synonym: upregulation of peripheral tolerance induction
has related synonym: activation of peripheral tolerance induction
has related synonym: stimulation of peripheral tolerance induction
type: Class
subclass of: positive regulation of tolerance induction dependent upon immune response
subclass of: regulation of peripheral tolerance induction

regulation of B cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: regulation of B lymphocyte tolerance induction
has exact synonym: regulation of B-cell tolerance induction
has exact synonym: regulation of B-lymphocyte tolerance induction
type: Class
subclass of: regulation of tolerance induction

negative regulation of B cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: down regulation of B cell tolerance induction
has exact synonym: down-regulation of B cell tolerance induction
has exact synonym: downregulation of B cell tolerance induction
has exact synonym: negative regulation of B lymphocyte tolerance induction
has exact synonym: negative regulation of B-cell tolerance induction
has exact synonym: negative regulation of B-lymphocyte tolerance induction
has related synonym: inhibition of B cell tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of B cell tolerance induction

positive regulation of B cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction.
has exact synonym: positive regulation of B lymphocyte tolerance induction
has exact synonym: positive regulation of B-cell tolerance induction
has exact synonym: positive regulation of B-lymphocyte tolerance induction
has exact synonym: up regulation of B cell tolerance induction
has exact synonym: up-regulation of B cell tolerance induction
has exact synonym: upregulation of B cell tolerance induction
has related synonym: activation of B cell tolerance induction
has related synonym: stimulation of B cell tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of B cell tolerance induction

regulation of T cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: regulation of T lymphocyte tolerance induction
has exact synonym: regulation of T-cell tolerance induction
has exact synonym: regulation of T-lymphocyte tolerance induction
type: Class
subclass of: regulation of tolerance induction

negative regulation of T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: down regulation of T cell tolerance induction
has exact synonym: down-regulation of T cell tolerance induction
has exact synonym: downregulation of T cell tolerance induction
has exact synonym: negative regulation of T lymphocyte tolerance induction
has exact synonym: negative regulation of T-cell tolerance induction
has exact synonym: negative regulation of T-lymphocyte tolerance induction
has related synonym: inhibition of T cell tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of T cell tolerance induction

positive regulation of T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
has exact synonym: positive regulation of T lymphocyte tolerance induction
has exact synonym: positive regulation of T-cell tolerance induction
has exact synonym: positive regulation of T-lymphocyte tolerance induction
has exact synonym: up regulation of T cell tolerance induction
has exact synonym: up-regulation of T cell tolerance induction
has exact synonym: upregulation of T cell tolerance induction
has related synonym: activation of T cell tolerance induction
has related synonym: stimulation of T cell tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of T cell tolerance induction

regulation of T cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell anergy.
has exact synonym: regulation of T lymphocyte anergy
has exact synonym: regulation of T-cell anergy
has exact synonym: regulation of T-lymphocyte anergy
type: Class
subclass of: regulation of T cell tolerance induction
subclass of: regulation of lymphocyte anergy

negative regulation of T cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy.
has exact synonym: down regulation of T cell anergy
has exact synonym: down-regulation of T cell anergy
has exact synonym: downregulation of T cell anergy
has exact synonym: negative regulation of T lymphocyte anergy
has exact synonym: negative regulation of T-cell anergy
has exact synonym: negative regulation of T-lymphocyte anergy
has related synonym: inhibition of T cell anergy
type: Class
subclass of: negative regulation of T cell tolerance induction
subclass of: regulation of T cell anergy
subclass of: negative regulation of lymphocyte anergy

positive regulation of T cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell anergy.
has exact synonym: positive regulation of T lymphocyte anergy
has exact synonym: positive regulation of T-cell anergy
has exact synonym: positive regulation of T-lymphocyte anergy
has exact synonym: up regulation of T cell anergy
has exact synonym: up-regulation of T cell anergy
has exact synonym: upregulation of T cell anergy
has related synonym: activation of T cell anergy
has related synonym: stimulation of T cell anergy
type: Class
subclass of: positive regulation of T cell tolerance induction
subclass of: regulation of T cell anergy
subclass of: positive regulation of lymphocyte anergy

regulation of B cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell anergy.
has exact synonym: regulation of B lymphocyte anergy
has exact synonym: regulation of B-cell anergy
has exact synonym: regulation of B-lymphocyte anergy
type: Class
subclass of: regulation of B cell tolerance induction
subclass of: regulation of lymphocyte anergy

negative regulation of B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy.
has exact synonym: down regulation of B cell anergy
has exact synonym: down-regulation of B cell anergy
has exact synonym: downregulation of B cell anergy
has exact synonym: negative regulation of B lymphocyte anergy
has exact synonym: negative regulation of B-cell anergy
has exact synonym: negative regulation of B-lymphocyte anergy
has related synonym: inhibition of B cell anergy
type: Class
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of B cell anergy
subclass of: negative regulation of lymphocyte anergy

positive regulation of B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell anergy.
has exact synonym: positive regulation of B lymphocyte anergy
has exact synonym: positive regulation of B-cell anergy
has exact synonym: positive regulation of B-lymphocyte anergy
has exact synonym: up regulation of B cell anergy
has exact synonym: up-regulation of B cell anergy
has exact synonym: upregulation of B cell anergy
has related synonym: activation of B cell anergy
has related synonym: stimulation of B cell anergy
type: Class
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of B cell anergy
subclass of: positive regulation of lymphocyte anergy

regulation of acute inflammatory response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
type: Class
subclass of: GO_0050727

negative regulation of acute inflammatory response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
has exact synonym: down regulation of acute inflammatory response
has exact synonym: down-regulation of acute inflammatory response
has exact synonym: downregulation of acute inflammatory response
has related synonym: inhibition of acute inflammatory response
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0050728

positive regulation of acute inflammatory response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
has exact synonym: up regulation of acute inflammatory response
has exact synonym: up-regulation of acute inflammatory response
has exact synonym: upregulation of acute inflammatory response
has related synonym: activation of acute inflammatory response
has related synonym: stimulation of acute inflammatory response
type: Class
subclass of: regulation of acute inflammatory response
subclass of: GO_0050729

regulation of chronic inflammatory response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.
type: Class
subclass of: GO_0050727

negative regulation of chronic inflammatory response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
has exact synonym: down regulation of chronic inflammatory response
has exact synonym: down-regulation of chronic inflammatory response
has exact synonym: downregulation of chronic inflammatory response
has related synonym: inhibition of chronic inflammatory response
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: GO_0050728

positive regulation of chronic inflammatory response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.
has exact synonym: up regulation of chronic inflammatory response
has exact synonym: up-regulation of chronic inflammatory response
has exact synonym: upregulation of chronic inflammatory response
has related synonym: activation of chronic inflammatory response
has related synonym: stimulation of chronic inflammatory response
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: GO_0050729

respiratory burst involved in defense response
IAO_0000115: A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
type: Class
subclass of: immune effector process
subclass of: part-of-parent-6952
subclass of: GO_0045730

pro-T cell lineage commitment
IAO_0000115: The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell.
has exact synonym: pro-T cell fate commitment
has exact synonym: pro-T lymphocyte fate commitment
has exact synonym: pro-T lymphocyte lineage commitment
type: Class
subclass of: part-of-parent-2572
subclass of: GO_0045165

somatic recombination of T cell receptor gene segments
IAO_0000115: The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments.
has exact synonym: somatic recombination of TCR gene segments
type: Class
subclass of: somatic diversification of immune receptors via germline recombination within a single locus
subclass of: somatic diversification of T cell receptor genes

regulation of immune system process
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune system process.
type: Class
subclass of: GO_0050789

negative regulation of immune system process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
has exact synonym: down regulation of immune system process
has exact synonym: down-regulation of immune system process
has exact synonym: downregulation of immune system process
has related synonym: inhibition of immune system process
type: Class
subclass of: regulation of immune system process
subclass of: GO_0048519

positive regulation of immune system process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune system process.
has exact synonym: up regulation of immune system process
has exact synonym: up-regulation of immune system process
has exact synonym: upregulation of immune system process
has related synonym: activation of immune system process
has related synonym: stimulation of immune system process
type: Class
subclass of: regulation of immune system process
subclass of: GO_0048518

regulation of leukocyte migration
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte migration.
has exact synonym: regulation of immune cell migration
has exact synonym: regulation of leucocyte migration
type: Class
subclass of: regulation of immune system process
subclass of: GO_0030334

negative regulation of leukocyte migration
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
has exact synonym: down regulation of leukocyte migration
has exact synonym: down-regulation of leukocyte migration
has exact synonym: downregulation of leukocyte migration
has exact synonym: negative regulation of immune cell migration
has exact synonym: negative regulation of leucocyte migration
has related synonym: inhibition of leukocyte migration
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte migration
subclass of: GO_0030336

positive regulation of leukocyte migration
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
has exact synonym: positive regulation of immune cell migration
has exact synonym: positive regulation of leucocyte migration
has exact synonym: up regulation of leukocyte migration
has exact synonym: up-regulation of leukocyte migration
has exact synonym: upregulation of leukocyte migration
has related synonym: activation of leukocyte migration
has related synonym: stimulation of leukocyte migration
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte migration
subclass of: GO_0030335

regulation of leukocyte chemotaxis
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: regulation of immune cell chemotaxis
has exact synonym: regulation of leucocyte chemotaxis
type: Class
subclass of: regulation of leukocyte migration
subclass of: GO_0050920

negative regulation of leukocyte chemotaxis
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: down regulation of leukocyte chemotaxis
has exact synonym: down-regulation of leukocyte chemotaxis
has exact synonym: downregulation of leukocyte chemotaxis
has exact synonym: negative regulation of immune cell chemotaxis
has exact synonym: negative regulation of leucocyte chemotaxis
has related synonym: inhibition of leukocyte chemotaxis
type: Class
subclass of: negative regulation of leukocyte migration
subclass of: regulation of leukocyte chemotaxis
subclass of: GO_0050922

positive regulation of leukocyte chemotaxis
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
has exact synonym: positive regulation of immune cell chemotaxis
has exact synonym: positive regulation of leucocyte chemotaxis
has exact synonym: up regulation of leukocyte chemotaxis
has exact synonym: up-regulation of leukocyte chemotaxis
has exact synonym: upregulation of leukocyte chemotaxis
has related synonym: activation of leukocyte chemotaxis
has related synonym: stimulation of leukocyte chemotaxis
type: Class
subclass of: positive regulation of leukocyte migration
subclass of: regulation of leukocyte chemotaxis
subclass of: GO_0050921

regulation of cellular extravasation
IAO_0000115: Any process that modulates the frequency, rate, or extent of cellular extravasation.
type: Class
subclass of: regulation of leukocyte migration

negative regulation of cellular extravasation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.
has exact synonym: down regulation of cellular extravasation
has exact synonym: down-regulation of cellular extravasation
has exact synonym: downregulation of cellular extravasation
has related synonym: inhibition of cellular extravasation
type: Class
subclass of: negative regulation of leukocyte migration
subclass of: regulation of cellular extravasation

positive regulation of cellular extravasation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cellular extravasation.
has exact synonym: up regulation of cellular extravasation
has exact synonym: up-regulation of cellular extravasation
has exact synonym: upregulation of cellular extravasation
has related synonym: activation of cellular extravasation
has related synonym: stimulation of cellular extravasation
type: Class
subclass of: positive regulation of leukocyte migration
subclass of: regulation of cellular extravasation

regulation of leukocyte activation
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte activation.
has exact synonym: regulation of immune cell activation
has exact synonym: regulation of leucocyte activation
type: Class
subclass of: regulation of immune system process
subclass of: GO_0050865

negative regulation of leukocyte activation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
has exact synonym: down regulation of leukocyte activation
has exact synonym: down-regulation of leukocyte activation
has exact synonym: downregulation of leukocyte activation
has exact synonym: negative regulation of immune cell activation
has exact synonym: negative regulation of leucocyte activation
has related synonym: inhibition of leukocyte activation
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050866

positive regulation of leukocyte activation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
has exact synonym: positive regulation of immune cell activation
has exact synonym: positive regulation of leucocyte activation
has exact synonym: up regulation of leukocyte activation
has exact synonym: up-regulation of leukocyte activation
has exact synonym: upregulation of leukocyte activation
has related synonym: activation of leukocyte activation
has related synonym: stimulation of leukocyte activation
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050867

regulation of immune effector process
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune effector process.
type: Class
subclass of: regulation of immune system process

negative regulation of immune effector process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
has exact synonym: down regulation of immune effector process
has exact synonym: down-regulation of immune effector process
has exact synonym: downregulation of immune effector process
has related synonym: inhibition of immune effector process
type: Class
subclass of: negative regulation of immune system process
subclass of: regulation of immune effector process

positive regulation of immune effector process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune effector process.
has exact synonym: up regulation of immune effector process
has exact synonym: up-regulation of immune effector process
has exact synonym: upregulation of immune effector process
has related synonym: activation of immune effector process
has related synonym: stimulation of immune effector process
type: Class
subclass of: positive regulation of immune system process
subclass of: regulation of immune effector process

regulation of production of molecular mediator of immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.
type: Class
subclass of: regulation of immune effector process

negative regulation of production of molecular mediator of immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.
has exact synonym: down regulation of production of molecular mediator of immune response
has exact synonym: down-regulation of production of molecular mediator of immune response
has exact synonym: downregulation of production of molecular mediator of immune response
has related synonym: inhibition of production of molecular mediator of immune response
type: Class
subclass of: negative regulation of immune effector process
subclass of: regulation of production of molecular mediator of immune response

positive regulation of production of molecular mediator of immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.
has exact synonym: up regulation of production of molecular mediator of immune response
has exact synonym: up-regulation of production of molecular mediator of immune response
has exact synonym: upregulation of production of molecular mediator of immune response
has related synonym: activation of production of molecular mediator of immune response
has related synonym: stimulation of production of molecular mediator of immune response
type: Class
subclass of: positive regulation of immune effector process
subclass of: regulation of production of molecular mediator of immune response

regulation of leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: regulation of immune cell mediated immunity
has exact synonym: regulation of leucocyte mediated immunity
type: Class
subclass of: regulation of immune effector process

negative regulation of leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: down regulation of leukocyte mediated immunity
has exact synonym: down-regulation of leukocyte mediated immunity
has exact synonym: downregulation of leukocyte mediated immunity
has exact synonym: negative regulation of immune cell mediated immunity
has exact synonym: negative regulation of leucocyte mediated immunity
has related synonym: inhibition of leukocyte mediated immunity
type: Class
subclass of: negative regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity

positive regulation of leukocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
has exact synonym: positive regulation of immune cell mediated immunity
has exact synonym: positive regulation of leucocyte mediated immunity
has exact synonym: up regulation of leukocyte mediated immunity
has exact synonym: up-regulation of leukocyte mediated immunity
has exact synonym: upregulation of leukocyte mediated immunity
has related synonym: activation of leukocyte mediated immunity
has related synonym: stimulation of leukocyte mediated immunity
type: Class
subclass of: positive regulation of immune effector process
subclass of: regulation of leukocyte mediated immunity

regulation of lymphocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
type: Class
subclass of: regulation of leukocyte mediated immunity

negative regulation of lymphocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
has exact synonym: down regulation of lymphocyte mediated immunity
has exact synonym: down-regulation of lymphocyte mediated immunity
has exact synonym: downregulation of lymphocyte mediated immunity
has related synonym: inhibition of lymphocyte mediated immunity
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity

positive regulation of lymphocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
has exact synonym: up regulation of lymphocyte mediated immunity
has exact synonym: up-regulation of lymphocyte mediated immunity
has exact synonym: upregulation of lymphocyte mediated immunity
has related synonym: activation of lymphocyte mediated immunity
has related synonym: stimulation of lymphocyte mediated immunity
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of lymphocyte mediated immunity

regulation of T cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: regulation of T lymphocyte mediated immunity
has exact synonym: regulation of T-cell mediated immunity
has exact synonym: regulation of T-lymphocyte mediated immunity
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

negative regulation of T cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: down regulation of T cell mediated immunity
has exact synonym: down-regulation of T cell mediated immunity
has exact synonym: downregulation of T cell mediated immunity
has exact synonym: negative regulation of T lymphocyte mediated immunity
has exact synonym: negative regulation of T-cell mediated immunity
has exact synonym: negative regulation of T-lymphocyte mediated immunity
has related synonym: inhibition of T cell mediated immunity
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of T cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

positive regulation of T cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.
has exact synonym: positive regulation of T lymphocyte mediated immunity
has exact synonym: positive regulation of T-cell mediated immunity
has exact synonym: positive regulation of T-lymphocyte mediated immunity
has exact synonym: up regulation of T cell mediated immunity
has exact synonym: up-regulation of T cell mediated immunity
has exact synonym: upregulation of T cell mediated immunity
has related synonym: activation of T cell mediated immunity
has related synonym: stimulation of T cell mediated immunity
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of T cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

regulation of B cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: regulation of B lymphocyte mediated immunity
has exact synonym: regulation of B-cell mediated immunity
has exact synonym: regulation of B-lymphocyte mediated immunity
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

negative regulation of B cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: down regulation of B cell mediated immunity
has exact synonym: down-regulation of B cell mediated immunity
has exact synonym: downregulation of B cell mediated immunity
has exact synonym: negative regulation of B lymphocyte mediated immunity
has exact synonym: negative regulation of B-cell mediated immunity
has exact synonym: negative regulation of B-lymphocyte mediated immunity
has related synonym: inhibition of B cell mediated immunity
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

positive regulation of B cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.
has exact synonym: positive regulation of B lymphocyte mediated immunity
has exact synonym: positive regulation of B-cell mediated immunity
has exact synonym: positive regulation of B-lymphocyte mediated immunity
has exact synonym: up regulation of B cell mediated immunity
has exact synonym: up-regulation of B cell mediated immunity
has exact synonym: upregulation of B cell mediated immunity
has related synonym: activation of B cell mediated immunity
has related synonym: stimulation of B cell mediated immunity
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of B cell mediated immunity
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

regulation of natural killer cell mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.
has exact synonym: regulation of NK cell mediated immunity
has related synonym: regulation of natural killer cell activity
replaces: GO_0045845
type: Class
subclass of: regulation of lymphocyte mediated immunity
subclass of: GO_0045088

negative regulation of natural killer cell mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.
has exact synonym: down regulation of natural killer cell mediated immunity
has exact synonym: down-regulation of natural killer cell mediated immunity
has exact synonym: downregulation of natural killer cell mediated immunity
has exact synonym: negative regulation of NK cell mediated immunity
has related synonym: inhibition of natural killer cell mediated immunity
has related synonym: negative regulation of NK cell activity
has related synonym: negative regulation of natural killer cell activity
replaces: GO_0030102
type: Class
subclass of: negative regulation of lymphocyte mediated immunity
subclass of: regulation of natural killer cell mediated immunity
subclass of: GO_0045824

positive regulation of natural killer cell mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.
has exact synonym: positive regulation of NK cell mediated immunity
has exact synonym: up regulation of natural killer cell mediated immunity
has exact synonym: up-regulation of natural killer cell mediated immunity
has exact synonym: upregulation of natural killer cell mediated immunity
has related synonym: activation of natural killer cell mediated immunity
has related synonym: positive regulation of NK cell activity
has related synonym: positive regulation of natural killer cell activity
has related synonym: stimulation of natural killer cell mediated immunity
replaces: GO_0045846
type: Class
subclass of: positive regulation of lymphocyte mediated immunity
subclass of: regulation of natural killer cell mediated immunity
subclass of: GO_0045089

regulation of cytokine production involved in immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.
has related synonym: regulation of cytokine biosynthetic process involved in immune response
has related synonym: regulation of cytokine production during immune response
has related synonym: regulation of cytokine secretion involved in immune response
replaces: GO_0002739
replaces: GO_0002742
type: Class
subclass of: regulation of cytokine production
subclass of: regulation of production of molecular mediator of immune response
subclass of: GO_0050776

negative regulation of cytokine production involved in immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.
has exact synonym: down-regulation of cytokine production during immune response
has related synonym: down regulation of cytokine production during immune response
has related synonym: downregulation of cytokine production during immune response
has related synonym: inhibition of cytokine production during immune response
has related synonym: negative regulation of cytokine biosynthetic process involved in immune response
has related synonym: negative regulation of cytokine production during immune response
has related synonym: negative regulation of cytokine secretion involved in immune response
replaces: GO_0002740
replaces: GO_0002743
type: Class
subclass of: negative regulation of cytokine production
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: regulation of cytokine production involved in immune response
subclass of: GO_0050777

positive regulation of cytokine production involved in immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
has related synonym: activation of cytokine production during immune response
has related synonym: positive regulation of cytokine biosynthetic process involved in immune response
has related synonym: positive regulation of cytokine production during immune response
has related synonym: positive regulation of cytokine secretion involved in immune response
has related synonym: stimulation of cytokine production during immune response
has related synonym: up regulation of cytokine production during immune response
has related synonym: up-regulation of cytokine production during immune response
has related synonym: upregulation of cytokine production during immune response
replaces: GO_0002741
replaces: GO_0002744
type: Class
subclass of: positive regulation of cytokine production
subclass of: positive regulation of production of molecular mediator of immune response
subclass of: regulation of cytokine production involved in immune response
subclass of: GO_0050778

regulation of B cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell cytokine production.
has exact synonym: regulation of B lymphocyte cytokine production
has exact synonym: regulation of B-cell cytokine production
has exact synonym: regulation of B-lymphocyte cytokine production
type: Class
subclass of: regulation of B cell mediated immunity
subclass of: regulation of cytokine production involved in immune response

negative regulation of B cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production.
has exact synonym: down regulation of B cell cytokine production
has exact synonym: down-regulation of B cell cytokine production
has exact synonym: downregulation of B cell cytokine production
has exact synonym: negative regulation of B lymphocyte cytokine production
has exact synonym: negative regulation of B-cell cytokine production
has exact synonym: negative regulation of B-lymphocyte cytokine production
has related synonym: inhibition of B cell cytokine production
type: Class
subclass of: negative regulation of B cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of B cell cytokine production

positive regulation of B cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell cytokine production.
has exact synonym: positive regulation of B lymphocyte cytokine production
has exact synonym: positive regulation of B-cell cytokine production
has exact synonym: positive regulation of B-lymphocyte cytokine production
has exact synonym: up regulation of B cell cytokine production
has exact synonym: up-regulation of B cell cytokine production
has exact synonym: upregulation of B cell cytokine production
has related synonym: activation of B cell cytokine production
has related synonym: stimulation of B cell cytokine production
type: Class
subclass of: positive regulation of B cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of B cell cytokine production

regulation of T cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell cytokine production.
has exact synonym: regulation of T lymphocyte cytokine production
has exact synonym: regulation of T-cell cytokine production
has exact synonym: regulation of T-lymphocyte cytokine production
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of cytokine production involved in immune response

negative regulation of T cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
has exact synonym: down regulation of T cell cytokine production
has exact synonym: down-regulation of T cell cytokine production
has exact synonym: downregulation of T cell cytokine production
has exact synonym: negative regulation of T lymphocyte cytokine production
has exact synonym: negative regulation of T-cell cytokine production
has exact synonym: negative regulation of T-lymphocyte cytokine production
has related synonym: inhibition of T cell cytokine production
type: Class
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of T cell cytokine production

positive regulation of T cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
has exact synonym: positive regulation of T lymphocyte cytokine production
has exact synonym: positive regulation of T-cell cytokine production
has exact synonym: positive regulation of T-lymphocyte cytokine production
has exact synonym: up regulation of T cell cytokine production
has exact synonym: up-regulation of T cell cytokine production
has exact synonym: upregulation of T cell cytokine production
has related synonym: activation of T cell cytokine production
has related synonym: stimulation of T cell cytokine production
type: Class
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of T cell cytokine production

regulation of natural killer cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: regulation of NK cell cytokine production
type: Class
subclass of: regulation of natural killer cell mediated immunity
subclass of: regulation of cytokine production involved in immune response

negative regulation of natural killer cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: down regulation of natural killer cell cytokine production
has exact synonym: down-regulation of natural killer cell cytokine production
has exact synonym: downregulation of natural killer cell cytokine production
has exact synonym: negative regulation of NK cell cytokine production
has related synonym: inhibition of natural killer cell cytokine production
type: Class
subclass of: negative regulation of natural killer cell mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of natural killer cell cytokine production

positive regulation of natural killer cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.
has exact synonym: positive regulation of NK cell cytokine production
has exact synonym: up regulation of natural killer cell cytokine production
has exact synonym: up-regulation of natural killer cell cytokine production
has exact synonym: upregulation of natural killer cell cytokine production
has related synonym: activation of natural killer cell cytokine production
has related synonym: stimulation of natural killer cell cytokine production
type: Class
subclass of: positive regulation of natural killer cell mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of natural killer cell cytokine production

regulation of dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.
type: Class
subclass of: regulation of leukocyte mediated immunity
subclass of: regulation of cytokine production involved in immune response

negative regulation of dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.
has exact synonym: down regulation of dendritic cell cytokine production
has exact synonym: down-regulation of dendritic cell cytokine production
has exact synonym: downregulation of dendritic cell cytokine production
has related synonym: inhibition of dendritic cell cytokine production
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: negative regulation of cytokine production involved in immune response
subclass of: regulation of dendritic cell cytokine production

positive regulation of dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.
has exact synonym: up regulation of dendritic cell cytokine production
has exact synonym: up-regulation of dendritic cell cytokine production
has exact synonym: upregulation of dendritic cell cytokine production
has related synonym: activation of dendritic cell cytokine production
has related synonym: stimulation of dendritic cell cytokine production
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: positive regulation of cytokine production involved in immune response
subclass of: regulation of dendritic cell cytokine production

regulation of myeloid dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.
type: Class
subclass of: regulation of dendritic cell cytokine production
subclass of: regulation of myeloid leukocyte mediated immunity

negative regulation of myeloid dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has exact synonym: down regulation of myeloid dendritic cell cytokine production
has exact synonym: down-regulation of myeloid dendritic cell cytokine production
has exact synonym: downregulation of myeloid dendritic cell cytokine production
has related synonym: inhibition of myeloid dendritic cell cytokine production
type: Class
subclass of: negative regulation of dendritic cell cytokine production
subclass of: regulation of myeloid dendritic cell cytokine production
subclass of: negative regulation of myeloid leukocyte mediated immunity

positive regulation of myeloid dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.
has exact synonym: up regulation of myeloid dendritic cell cytokine production
has exact synonym: up-regulation of myeloid dendritic cell cytokine production
has exact synonym: upregulation of myeloid dendritic cell cytokine production
has related synonym: activation of myeloid dendritic cell cytokine production
has related synonym: stimulation of myeloid dendritic cell cytokine production
type: Class
subclass of: positive regulation of dendritic cell cytokine production
subclass of: regulation of myeloid dendritic cell cytokine production
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: GO_0061081

regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
type: Class
subclass of: regulation of dendritic cell cytokine production

negative regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has exact synonym: down regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: down-regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: downregulation of plasmacytoid dendritic cell cytokine production
has related synonym: inhibition of plasmacytoid dendritic cell cytokine production
type: Class
subclass of: negative regulation of dendritic cell cytokine production
subclass of: regulation of plasmacytoid dendritic cell cytokine production

positive regulation of plasmacytoid dendritic cell cytokine production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
has exact synonym: up regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: up-regulation of plasmacytoid dendritic cell cytokine production
has exact synonym: upregulation of plasmacytoid dendritic cell cytokine production
has related synonym: activation of plasmacytoid dendritic cell cytokine production
has related synonym: stimulation of plasmacytoid dendritic cell cytokine production
type: Class
subclass of: positive regulation of dendritic cell cytokine production
subclass of: regulation of plasmacytoid dendritic cell cytokine production

antigen processing and presentation initiated by receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor.
type: Class
subclass of: GO_0019882

antigen processing and presentation following pinocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
type: Class
subclass of: GO_0019882

antigen processing and presentation following phagocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis.
type: Class
subclass of: GO_0019882

antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR).
has exact synonym: antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen
has exact synonym: antigen processing and presentation initiated by PRR mediated uptake of antigen
type: Class
subclass of: antigen processing and presentation initiated by receptor mediated uptake of antigen

antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
IAO_0000115: Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR).
has exact synonym: antigen processing and presentation initiated by TLR mediated phagocytosis of antigen
type: Class
subclass of: antigen processing and presentation following phagocytosis
subclass of: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

antigen processing and presentation following macropinocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis.
type: Class
subclass of: antigen processing and presentation following pinocytosis

antigen processing and presentation following receptor mediated endocytosis
IAO_0000115: Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis.
type: Class
subclass of: antigen processing and presentation initiated by receptor mediated uptake of antigen

cell surface pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
has exact synonym: cell surface PAMP receptor signaling pathway
has exact synonym: cell surface PRR signaling pathway
has exact synonym: cell surface pathogen receptor signaling pathway
has exact synonym: cell surface pattern recognition receptor signalling pathway
type: Class
subclass of: innate immune response activating cell surface receptor signaling pathway
subclass of: pattern recognition receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
has exact synonym: cytoplasmic PAMP receptor signaling pathway
has exact synonym: cytoplasmic PRR signaling pathway
has exact synonym: cytoplasmic pathogen receptor signaling pathway
has exact synonym: cytoplasmic pattern recognition receptor signalling pathway
type: Class
subclass of: pattern recognition receptor signaling pathway
subclass of: GO_0030522
subclass of: GO_0035556

intracellular endosomal pattern recognition receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
has related synonym: intracellular vesicle PAMP receptor signaling pathway
has related synonym: intracellular vesicle PRR signaling pathway
has related synonym: intracellular vesicle pathogen receptor signaling pathway
has related synonym: intracellular vesicle pattern recognition receptor signaling pathway
has related synonym: intracellular vesicle pattern recognition receptor signalling pathway
type: Class
subclass of: pattern recognition receptor signaling pathway
subclass of: GO_0030522

MyD88-dependent toll-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has exact synonym: MyD88-dependent TLR signaling pathway
has exact synonym: MyD88-dependent toll-like receptor signalling pathway
type: Class
subclass of: toll-like receptor signaling pathway

MyD88-independent toll-like receptor signaling pathway
IAO_0000115: Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
has exact synonym: MyD88-independent TLR signaling pathway
has exact synonym: MyD88-independent toll-like receptor signalling pathway
type: Class
subclass of: toll-like receptor signaling pathway

immune response-activating signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response.
type: Class
subclass of: activation of immune response
subclass of: immune response-regulating signaling pathway

innate immune response-activating signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response.
has related synonym: defence response signaling pathway, resistance gene-independent
has related synonym: defence response signalling pathway, resistance gene-independent
has related synonym: defense response signaling pathway, resistance gene-independent
replaces: GO_0010204
type: Class
subclass of: activation of innate immune response
subclass of: immune response-activating signal transduction

regulation of antimicrobial humoral response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: regulation of humoral immune response
subclass of: GO_0032101

positive regulation of antimicrobial humoral response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.
has exact synonym: up regulation of antimicrobial humoral response
has exact synonym: up-regulation of antimicrobial humoral response
has exact synonym: upregulation of antimicrobial humoral response
has related synonym: activation of antimicrobial humoral response
has related synonym: stimulation of antimicrobial humoral response
type: Class
subclass of: regulation of antimicrobial humoral response
subclass of: positive regulation of response to biotic stimulus
subclass of: positive regulation of humoral immune response
subclass of: GO_0032103

regulation of myeloid leukocyte differentiation
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.
type: Class
subclass of: GO_0045637
subclass of: GO_1902105

negative regulation of myeloid leukocyte differentiation
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
has exact synonym: down regulation of myeloid leukocyte differentiation
has exact synonym: down-regulation of myeloid leukocyte differentiation
has exact synonym: downregulation of myeloid leukocyte differentiation
has related synonym: inhibition of myeloid leukocyte differentiation
type: Class
subclass of: regulation of myeloid leukocyte differentiation
subclass of: GO_0045638
subclass of: GO_1902106

positive regulation of myeloid leukocyte differentiation
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
has exact synonym: up regulation of myeloid leukocyte differentiation
has exact synonym: up-regulation of myeloid leukocyte differentiation
has exact synonym: upregulation of myeloid leukocyte differentiation
has related synonym: activation of myeloid leukocyte differentiation
has related synonym: stimulation of myeloid leukocyte differentiation
type: Class
subclass of: regulation of myeloid leukocyte differentiation
subclass of: GO_0045639
subclass of: GO_1902107

immune response-regulating signaling pathway
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.
has exact synonym: immune response-regulating signalling pathway
type: Class
subclass of: GO_0007165
subclass of: GO_0050776

immune response-inhibiting signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.
type: Class
subclass of: immune response-regulating signaling pathway

innate immune response-inhibiting signal transduction
IAO_0000115: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response.
type: Class
subclass of: immune response-inhibiting signal transduction

immune response-inhibiting cell surface receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.
has exact synonym: immune response-inhibiting cell surface receptor signalling pathway
type: Class
subclass of: immune response-inhibiting signal transduction
subclass of: immune response-regulating cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
has exact synonym: immune response-regulating cell surface receptor signalling pathway
type: Class
subclass of: immune response-regulating signaling pathway
subclass of: GO_0007166

natural killer cell inhibitory signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: NK cell inhibitory signaling pathway
has exact synonym: natural killer cell inhibitory signalling pathway
has related synonym: Ly49 inhibitory receptor signaling pathway
has related synonym: inhibitory KIR signaling pathway
has related synonym: killer cell inhibitory receptor signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

T cell inhibitory signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: T cell inhibitory signalling pathway
has exact synonym: T lymphocyte inhibitory signaling pathway
has exact synonym: T-cell inhibitory signaling pathway
has exact synonym: T-lymphocyte inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

inhibitory killer cell immunoglobulin-like receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: KIR signaling pathway
has exact synonym: inhibitory killer cell immunoglobulin-like receptor signalling pathway
has exact synonym: killer cell inhibitory receptor signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

inhibitory C-type lectin receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: inhibitory C-type lectin receptor signalling pathway
has related synonym: Ly49 inhibitory receptor signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

B cell inhibitory signaling pathway
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response.
has exact synonym: B cell inhibitory signalling pathway
has exact synonym: B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway
has exact synonym: B-cell inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

Fc receptor mediated inhibitory signaling pathway
IAO_0000115: A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
has exact synonym: Fc receptor mediated inhibitory signalling pathway
has exact synonym: Fc-receptor mediated inhibitory signaling pathway
type: Class
subclass of: immune response-inhibiting cell surface receptor signaling pathway

antimicrobial peptide production
IAO_0000115: The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
type: Class
subclass of: production of molecular mediator of immune response
subclass of: part-of-parent-61844

antimicrobial peptide secretion
IAO_0000115: The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
type: Class
subclass of: part-of-parent-2775
subclass of: peptide secretion

antimicrobial peptide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
type: Class
subclass of: part-of-parent-2775
subclass of: GO_0043043

antibacterial peptide production
IAO_0000115: The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
type: Class
subclass of: antimicrobial peptide production
subclass of: part-of-parent-19731

antibacterial peptide secretion
IAO_0000115: The regulated release of an antibacterial peptide from a cell or a tissue.
type: Class
subclass of: antimicrobial peptide secretion
subclass of: part-of-parent-2778

antibacterial peptide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide.
type: Class
subclass of: antimicrobial peptide biosynthetic process
subclass of: part-of-parent-2778

antifungal peptide production
IAO_0000115: The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
type: Class
subclass of: antimicrobial peptide production
subclass of: part-of-parent-19732

antifungal peptide secretion
IAO_0000115: The regulated release of an antifungal peptide from a cell or a tissue.
type: Class
subclass of: antimicrobial peptide secretion
subclass of: part-of-parent-2781

antifungal peptide biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antifungal peptide.
type: Class
subclass of: antimicrobial peptide biosynthetic process
subclass of: part-of-parent-2781

regulation of antimicrobial peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.
type: Class
subclass of: regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial humoral response

negative regulation of antimicrobial peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.
has exact synonym: down regulation of antimicrobial peptide production
has exact synonym: down-regulation of antimicrobial peptide production
has exact synonym: downregulation of antimicrobial peptide production
has related synonym: inhibition of antimicrobial peptide production
type: Class
subclass of: negative regulation of production of molecular mediator of immune response
subclass of: regulation of antimicrobial peptide production
subclass of: GO_0008348

regulation of antibacterial peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide production.
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_1900424

negative regulation of antibacterial peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production.
has exact synonym: down regulation of antibacterial peptide production
has exact synonym: down-regulation of antibacterial peptide production
has exact synonym: downregulation of antibacterial peptide production
has related synonym: inhibition of antibacterial peptide production
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antibacterial peptide production
subclass of: GO_1900425

regulation of antifungal peptide production
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide production.
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_1900150

negative regulation of antifungal peptide production
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production.
has exact synonym: down regulation of antifungal peptide production
has exact synonym: down-regulation of antifungal peptide production
has exact synonym: downregulation of antifungal peptide production
has related synonym: inhibition of antifungal peptide production
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antifungal peptide production
subclass of: GO_0031348

peptide secretion
IAO_0000115: The controlled release of a peptide from a cell or a tissue.
type: Class
subclass of: GO_0015833
subclass of: GO_0046903

regulation of peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of peptide secretion.
type: Class
subclass of: GO_0051046
subclass of: GO_0090087

negative regulation of peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
has exact synonym: down regulation of peptide secretion
has exact synonym: down-regulation of peptide secretion
has exact synonym: downregulation of peptide secretion
has related synonym: inhibition of peptide secretion
type: Class
subclass of: regulation of peptide secretion
subclass of: GO_0051048

positive regulation of peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peptide secretion.
has exact synonym: up regulation of peptide secretion
has exact synonym: up-regulation of peptide secretion
has exact synonym: upregulation of peptide secretion
has related synonym: activation of peptide secretion
has related synonym: stimulation of peptide secretion
type: Class
subclass of: regulation of peptide secretion
subclass of: GO_0051047

regulation of antimicrobial peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: regulation of peptide secretion

negative regulation of antimicrobial peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.
has exact synonym: down regulation of antimicrobial peptide secretion
has exact synonym: down-regulation of antimicrobial peptide secretion
has exact synonym: downregulation of antimicrobial peptide secretion
has related synonym: inhibition of antimicrobial peptide secretion
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: negative regulation of peptide secretion
subclass of: regulation of antimicrobial peptide secretion

positive regulation of antimicrobial peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.
has exact synonym: up regulation of antimicrobial peptide secretion
has exact synonym: up-regulation of antimicrobial peptide secretion
has exact synonym: upregulation of antimicrobial peptide secretion
has related synonym: activation of antimicrobial peptide secretion
has related synonym: stimulation of antimicrobial peptide secretion
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: positive regulation of peptide secretion
subclass of: regulation of antimicrobial peptide secretion

regulation of antibacterial peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion.
type: Class
subclass of: regulation of antibacterial peptide production
subclass of: regulation of antimicrobial peptide secretion

negative regulation of antibacterial peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion.
has exact synonym: down regulation of antibacterial peptide secretion
has exact synonym: down-regulation of antibacterial peptide secretion
has exact synonym: downregulation of antibacterial peptide secretion
has related synonym: inhibition of antibacterial peptide secretion
type: Class
subclass of: negative regulation of antibacterial peptide production
subclass of: negative regulation of antimicrobial peptide secretion
subclass of: regulation of antibacterial peptide secretion

positive regulation of antibacterial peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion.
has exact synonym: up regulation of antibacterial peptide secretion
has exact synonym: up-regulation of antibacterial peptide secretion
has exact synonym: upregulation of antibacterial peptide secretion
has related synonym: activation of antibacterial peptide secretion
has related synonym: stimulation of antibacterial peptide secretion
type: Class
subclass of: positive regulation of antimicrobial peptide secretion
subclass of: regulation of antibacterial peptide secretion
subclass of: positive regulation of antibacterial peptide production

regulation of antifungal peptide secretion
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide secretion.
type: Class
subclass of: regulation of antifungal peptide production
subclass of: regulation of antimicrobial peptide secretion

negative regulation of antifungal peptide secretion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion.
has exact synonym: down regulation of antifungal peptide secretion
has exact synonym: down-regulation of antifungal peptide secretion
has exact synonym: downregulation of antifungal peptide secretion
has related synonym: inhibition of antifungal peptide secretion
type: Class
subclass of: negative regulation of antifungal peptide production
subclass of: negative regulation of antimicrobial peptide secretion
subclass of: regulation of antifungal peptide secretion

positive regulation of antifungal peptide secretion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion.
has exact synonym: up regulation of antifungal peptide secretion
has exact synonym: up-regulation of antifungal peptide secretion
has exact synonym: upregulation of antifungal peptide secretion
has related synonym: activation of antifungal peptide secretion
has related synonym: stimulation of antifungal peptide secretion
type: Class
subclass of: positive regulation of antimicrobial peptide secretion
subclass of: regulation of antifungal peptide secretion
subclass of: positive regulation of antifungal peptide production

positive regulation of antibacterial peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production.
has exact synonym: up regulation of antibacterial peptide production
has exact synonym: up-regulation of antibacterial peptide production
has exact synonym: upregulation of antibacterial peptide production
has related synonym: activation of antibacterial peptide production
has related synonym: stimulation of antibacterial peptide production
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antibacterial peptide production
subclass of: GO_1900426

positive regulation of antifungal peptide production
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.
has exact synonym: up regulation of antifungal peptide production
has exact synonym: up-regulation of antifungal peptide production
has exact synonym: upregulation of antifungal peptide production
has related synonym: activation of antifungal peptide production
has related synonym: stimulation of antifungal peptide production
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antifungal peptide production
subclass of: GO_0031349

regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.
type: Class
subclass of: regulation of antimicrobial peptide production
subclass of: GO_0031326
subclass of: GO_0034248

negative regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has exact synonym: down regulation of antimicrobial peptide biosynthetic process
has exact synonym: down-regulation of antimicrobial peptide biosynthetic process
has exact synonym: downregulation of antimicrobial peptide biosynthetic process
has related synonym: inhibition of antimicrobial peptide biosynthetic process
type: Class
subclass of: negative regulation of antimicrobial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: GO_0031327
subclass of: GO_0034249

positive regulation of antimicrobial peptide biosynthetic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
has exact synonym: up regulation of antimicrobial peptide biosynthetic process
has exact synonym: up-regulation of antimicrobial peptide biosynthetic process
has exact synonym: upregulation of antimicrobial peptide biosynthetic process
has related synonym: activation of antimicrobial peptide biosynthetic process
has related synonym: stimulation of antimicrobial peptide biosynthetic process
type: Class
subclass of: positive regulation of antimicrobial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process
subclass of: GO_0031328
subclass of: GO_0034250

regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis.
type: Class
subclass of: regulation of antibacterial peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process

negative regulation of antibacterial peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.
has exact synonym: down regulation of antibacterial peptide biosynthetic process
has exact synonym: down-regulation of antibacterial peptide biosynthetic process
has exact synonym: downregulation of antibacterial peptide biosynthetic process
has related synonym: inhibition of antibacterial peptide biosynthetic process
type: Class
subclass of: negative regulation of antibacterial peptide production
subclass of: negative regulation of antimicrobial peptide biosynthetic process
subclass of: regulation of antibacterial peptide biosynthetic process

regulation of antifungal peptide biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis.
type: Class
subclass of: regulation of antifungal peptide production
subclass of: regulation of antimicrobial peptide biosynthetic process

negative regulation of antifungal peptide biosynthetic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis.
has exact synonym: down regulation of antifungal peptide biosynthetic process
has exact synonym: down-regulation of antifungal peptide biosynthetic process
has exact synonym: downregulation of antifungal peptide biosynthetic process
has related synonym: inhibition of antifungal peptide biosynthetic process
type: Class
subclass of: negative regulation of antifungal peptide production
subclass of: negative regulation of antimicrobial peptide biosynthetic process
subclass of: regulation of antifungal peptide biosynthetic process

biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria.
type: Class
subclass of: antibacterial peptide biosynthetic process
subclass of: part-of-parent-50829

regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
type: Class
subclass of: regulation of antibacterial peptide biosynthetic process

negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.
has exact synonym: down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has exact synonym: down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has exact synonym: downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
has related synonym: inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
type: Class
subclass of: negative regulation of antibacterial peptide biosynthetic process
subclass of: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria.
type: Class
subclass of: antibacterial peptide biosynthetic process
subclass of: part-of-parent-50830

regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
type: Class
subclass of: regulation of antibacterial peptide biosynthetic process

negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.
has exact synonym: down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has exact synonym: down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has exact synonym: downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
has related synonym: inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
type: Class
subclass of: negative regulation of antibacterial peptide biosynthetic process
subclass of: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

regulation of adaptive immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an adaptive immune response.
type: Class
subclass of: GO_0050776

negative regulation of adaptive immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
has exact synonym: down regulation of adaptive immune response
has exact synonym: down-regulation of adaptive immune response
has exact synonym: downregulation of adaptive immune response
has related synonym: inhibition of adaptive immune response
type: Class
subclass of: regulation of adaptive immune response
subclass of: GO_0050777

positive regulation of adaptive immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
has exact synonym: up regulation of adaptive immune response
has exact synonym: up-regulation of adaptive immune response
has exact synonym: upregulation of adaptive immune response
has related synonym: activation of adaptive immune response
has related synonym: stimulation of adaptive immune response
type: Class
subclass of: regulation of adaptive immune response
subclass of: GO_0050778

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
type: Class
subclass of: regulation of adaptive immune response

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
type: Class
subclass of: negative regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
type: Class
subclass of: positive regulation of adaptive immune response
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

regulation of T-helper 1 type immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response.
type: Class
subclass of: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

negative regulation of T-helper 1 type immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.
has exact synonym: down regulation of T-helper 1 type immune response
has exact synonym: down-regulation of T-helper 1 type immune response
has exact synonym: downregulation of T-helper 1 type immune response
has related synonym: inhibition of T-helper 1 type immune response
type: Class
subclass of: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of T-helper 1 type immune response

positive regulation of T-helper 1 type immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
has exact synonym: up regulation of T-helper 1 type immune response
has exact synonym: up-regulation of T-helper 1 type immune response
has exact synonym: upregulation of T-helper 1 type immune response
has related synonym: activation of T-helper 1 type immune response
has related synonym: stimulation of T-helper 1 type immune response
type: Class
subclass of: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
subclass of: regulation of T-helper 1 type immune response

regulation of type 2 immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a type 2 immune response.
has related synonym: regulation of T-helper 2 type immune response
has related synonym: regulation of Th2 immune response
type: Class
subclass of: GO_0050776

negative regulation of type 2 immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
has exact synonym: down regulation of type 2 immune response
has exact synonym: down-regulation of type 2 immune response
has exact synonym: downregulation of type 2 immune response
has related synonym: inhibition of type 2 immune response
has related synonym: negative regulation of T-helper 2 type immune response
has related synonym: negative regulation of Th2 immune response
type: Class
subclass of: regulation of type 2 immune response
subclass of: GO_0050777

positive regulation of type 2 immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
has exact synonym: up regulation of type 2 immune response
has exact synonym: up-regulation of type 2 immune response
has exact synonym: upregulation of type 2 immune response
has related synonym: activation of type 2 immune response
has related synonym: positive regulation of T-helper 2 type immune response
has related synonym: positive regulation of Th2 immune response
has related synonym: stimulation of type 2 immune response
type: Class
subclass of: regulation of type 2 immune response
subclass of: GO_0050778

regulation of response to biotic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
type: Class
subclass of: GO_0048583

negative regulation of response to biotic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
has exact synonym: down regulation of response to biotic stimulus
has exact synonym: down-regulation of response to biotic stimulus
has exact synonym: downregulation of response to biotic stimulus
has related synonym: inhibition of response to biotic stimulus
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: GO_0048585

positive regulation of response to biotic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
has exact synonym: up regulation of response to biotic stimulus
has exact synonym: up-regulation of response to biotic stimulus
has exact synonym: upregulation of response to biotic stimulus
has related synonym: activation of response to biotic stimulus
has related synonym: stimulation of response to biotic stimulus
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: GO_0048584

regulation of response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of a response to tumor cell.
has exact synonym: regulation of response to tumour cell
type: Class
subclass of: regulation of response to biotic stimulus

negative regulation of response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell.
has exact synonym: down regulation of response to tumor cell
has exact synonym: down-regulation of response to tumor cell
has exact synonym: downregulation of response to tumor cell
has exact synonym: negative regulation of response to tumour cell
has related synonym: inhibition of response to tumor cell
type: Class
subclass of: negative regulation of response to biotic stimulus
subclass of: regulation of response to tumor cell

positive regulation of response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a response to tumor cell.
has exact synonym: positive regulation of response to tumour cell
has exact synonym: up regulation of response to tumor cell
has exact synonym: up-regulation of response to tumor cell
has exact synonym: upregulation of response to tumor cell
has related synonym: activation of response to tumor cell
has related synonym: stimulation of response to tumor cell
type: Class
subclass of: positive regulation of response to biotic stimulus
subclass of: regulation of response to tumor cell

regulation of immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: regulation of immune response to tumour cell
type: Class
subclass of: regulation of response to tumor cell
subclass of: GO_0050776

negative regulation of immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: down regulation of immune response to tumor cell
has exact synonym: down-regulation of immune response to tumor cell
has exact synonym: downregulation of immune response to tumor cell
has exact synonym: negative regulation of immune response to tumour cell
has related synonym: inhibition of immune response to tumor cell
type: Class
subclass of: negative regulation of response to tumor cell
subclass of: regulation of immune response to tumor cell
subclass of: GO_0050777

positive regulation of immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.
has exact synonym: positive regulation of immune response to tumour cell
has exact synonym: up regulation of immune response to tumor cell
has exact synonym: up-regulation of immune response to tumor cell
has exact synonym: upregulation of immune response to tumor cell
has related synonym: activation of immune response to tumor cell
has related synonym: stimulation of immune response to tumor cell
type: Class
subclass of: positive regulation of response to tumor cell
subclass of: regulation of immune response to tumor cell
subclass of: GO_0050778

regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: regulation of T cell mediated immune response to tumour cell
has exact synonym: regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: regulation of T-cell mediated immune response to tumor cell
has exact synonym: regulation of T-lymphocyte mediated immune response to tumor cell
type: Class
subclass of: regulation of T cell mediated immunity
subclass of: regulation of immune response to tumor cell

negative regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: down regulation of T cell mediated immune response to tumor cell
has exact synonym: down-regulation of T cell mediated immune response to tumor cell
has exact synonym: downregulation of T cell mediated immune response to tumor cell
has exact synonym: negative regulation of T cell mediated immune response to tumour cell
has exact synonym: negative regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: negative regulation of T-cell mediated immune response to tumor cell
has exact synonym: negative regulation of T-lymphocyte mediated immune response to tumor cell
has related synonym: inhibition of T cell mediated immune response to tumor cell
type: Class
subclass of: negative regulation of T cell mediated immunity
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of T cell mediated immune response to tumor cell

positive regulation of T cell mediated immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell.
has exact synonym: positive regulation of T cell mediated immune response to tumour cell
has exact synonym: positive regulation of T lymphocyte mediated immune response to tumor cell
has exact synonym: positive regulation of T-cell mediated immune response to tumor cell
has exact synonym: positive regulation of T-lymphocyte mediated immune response to tumor cell
has exact synonym: up regulation of T cell mediated immune response to tumor cell
has exact synonym: up-regulation of T cell mediated immune response to tumor cell
has exact synonym: upregulation of T cell mediated immune response to tumor cell
has related synonym: activation of T cell mediated immune response to tumor cell
has related synonym: stimulation of T cell mediated immune response to tumor cell
type: Class
subclass of: positive regulation of T cell mediated immunity
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of T cell mediated immune response to tumor cell

regulation of tolerance induction to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: regulation of tolerance induction to tumour cell
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of immune response to tumor cell

negative regulation of tolerance induction to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: down regulation of tolerance induction to tumor cell
has exact synonym: down-regulation of tolerance induction to tumor cell
has exact synonym: downregulation of tolerance induction to tumor cell
has exact synonym: negative regulation of tolerance induction to tumour cell
has related synonym: inhibition of tolerance induction to tumor cell
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell

positive regulation of tolerance induction to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.
has exact synonym: positive regulation of tolerance induction to tumour cell
has exact synonym: up regulation of tolerance induction to tumor cell
has exact synonym: up-regulation of tolerance induction to tumor cell
has exact synonym: upregulation of tolerance induction to tumor cell
has related synonym: activation of tolerance induction to tumor cell
has related synonym: stimulation of tolerance induction to tumor cell
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell

regulation of T cell tolerance induction to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell.
type: Class
subclass of: regulation of T cell mediated immune response to tumor cell
subclass of: regulation of tolerance induction to tumor cell
subclass of: regulation of peripheral T cell tolerance induction

negative regulation of T cell tolerance induction to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has exact synonym: down regulation of T cell tolerance induction to tumor cell
has exact synonym: down-regulation of T cell tolerance induction to tumor cell
has exact synonym: downregulation of T cell tolerance induction to tumor cell
has related synonym: inhibition of T cell tolerance induction to tumor cell
type: Class
subclass of: negative regulation of T cell mediated immune response to tumor cell
subclass of: negative regulation of tolerance induction to tumor cell
subclass of: regulation of T cell tolerance induction to tumor cell
subclass of: negative regulation of peripheral T cell tolerance induction

positive regulation of T cell tolerance induction to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell.
has exact synonym: up regulation of T cell tolerance induction to tumor cell
has exact synonym: up-regulation of T cell tolerance induction to tumor cell
has exact synonym: upregulation of T cell tolerance induction to tumor cell
has related synonym: activation of T cell tolerance induction to tumor cell
has related synonym: stimulation of T cell tolerance induction to tumor cell
type: Class
subclass of: positive regulation of T cell mediated immune response to tumor cell
subclass of: positive regulation of tolerance induction to tumor cell
subclass of: regulation of T cell tolerance induction to tumor cell
subclass of: positive regulation of peripheral T cell tolerance induction

regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction.
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of T cell tolerance induction
subclass of: regulation of T cell mediated immunity

negative regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction.
has exact synonym: down regulation of peripheral T cell tolerance induction
has exact synonym: down-regulation of peripheral T cell tolerance induction
has exact synonym: downregulation of peripheral T cell tolerance induction
has related synonym: inhibition of peripheral T cell tolerance induction
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of T cell tolerance induction
subclass of: negative regulation of T cell mediated immunity
subclass of: regulation of peripheral T cell tolerance induction

positive regulation of peripheral T cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.
has exact synonym: up regulation of peripheral T cell tolerance induction
has exact synonym: up-regulation of peripheral T cell tolerance induction
has exact synonym: upregulation of peripheral T cell tolerance induction
has related synonym: activation of peripheral T cell tolerance induction
has related synonym: stimulation of peripheral T cell tolerance induction
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of T cell tolerance induction
subclass of: positive regulation of T cell mediated immunity
subclass of: regulation of peripheral T cell tolerance induction

regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
type: Class
subclass of: regulation of T cell mediated cytotoxicity
subclass of: regulation of T cell mediated immune response to tumor cell

negative regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has exact synonym: down regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down-regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: downregulation of T cell mediated cytotoxicity directed against tumor cell target
has related synonym: inhibition of T cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: negative regulation of T cell mediated cytotoxicity
subclass of: negative regulation of T cell mediated immune response to tumor cell
subclass of: regulation of T cell mediated cytotoxicity directed against tumor cell target

positive regulation of T cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.
has exact synonym: up regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up-regulation of T cell mediated cytotoxicity directed against tumor cell target
has exact synonym: upregulation of T cell mediated cytotoxicity directed against tumor cell target
has related synonym: activation of T cell mediated cytotoxicity directed against tumor cell target
has related synonym: stimulation of T cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: positive regulation of T cell mediated cytotoxicity
subclass of: positive regulation of T cell mediated immune response to tumor cell
subclass of: regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
type: Class
subclass of: regulation of natural killer cell mediated immunity
subclass of: regulation of immune response to tumor cell

negative regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has exact synonym: down regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: down-regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: downregulation of natural killer cell mediated immune response to tumor cell
has related synonym: inhibition of natural killer cell mediated immune response to tumor cell
type: Class
subclass of: negative regulation of natural killer cell mediated immunity
subclass of: negative regulation of immune response to tumor cell
subclass of: regulation of natural killer cell mediated immune response to tumor cell

positive regulation of natural killer cell mediated immune response to tumor cell
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.
has exact synonym: up regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: up-regulation of natural killer cell mediated immune response to tumor cell
has exact synonym: upregulation of natural killer cell mediated immune response to tumor cell
has related synonym: activation of natural killer cell mediated immune response to tumor cell
has related synonym: stimulation of natural killer cell mediated immune response to tumor cell
type: Class
subclass of: positive regulation of natural killer cell mediated immunity
subclass of: positive regulation of immune response to tumor cell
subclass of: regulation of natural killer cell mediated immune response to tumor cell

regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
type: Class
subclass of: regulation of natural killer cell mediated immune response to tumor cell
subclass of: GO_0042269

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has exact synonym: down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has related synonym: inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: negative regulation of natural killer cell mediated immune response to tumor cell
subclass of: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
subclass of: GO_0045953

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
has exact synonym: up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has exact synonym: upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target
has related synonym: activation of natural killer cell mediated cytotoxicity directed against tumor cell target
has related synonym: stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target
type: Class
subclass of: positive regulation of natural killer cell mediated immune response to tumor cell
subclass of: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
subclass of: GO_0045954

regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
type: Class
subclass of: GO_0050727
subclass of: GO_0050776

negative regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has exact synonym: down regulation of inflammatory response to antigenic stimulus
has exact synonym: down-regulation of inflammatory response to antigenic stimulus
has exact synonym: downregulation of inflammatory response to antigenic stimulus
has related synonym: inhibition of inflammatory response to antigenic stimulus
type: Class
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050728
subclass of: GO_0050777

positive regulation of inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.
has exact synonym: up regulation of inflammatory response to antigenic stimulus
has exact synonym: up-regulation of inflammatory response to antigenic stimulus
has exact synonym: upregulation of inflammatory response to antigenic stimulus
has related synonym: activation of inflammatory response to antigenic stimulus
has related synonym: stimulation of inflammatory response to antigenic stimulus
type: Class
subclass of: regulation of inflammatory response to antigenic stimulus
subclass of: GO_0050729
subclass of: GO_0050778

regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
type: Class
subclass of: regulation of acute inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus

negative regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has exact synonym: down regulation of acute inflammatory response to antigenic stimulus
has exact synonym: down-regulation of acute inflammatory response to antigenic stimulus
has exact synonym: downregulation of acute inflammatory response to antigenic stimulus
has related synonym: inhibition of acute inflammatory response to antigenic stimulus
type: Class
subclass of: negative regulation of acute inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.
has exact synonym: up regulation of acute inflammatory response to antigenic stimulus
has exact synonym: up-regulation of acute inflammatory response to antigenic stimulus
has exact synonym: upregulation of acute inflammatory response to antigenic stimulus
has related synonym: activation of acute inflammatory response to antigenic stimulus
has related synonym: stimulation of acute inflammatory response to antigenic stimulus
type: Class
subclass of: positive regulation of acute inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of acute inflammatory response to antigenic stimulus

regulation of B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell deletion.
has exact synonym: regulation of B lymphocyte deletion
has exact synonym: regulation of B-cell deletion
has exact synonym: regulation of B-lymphocyte deletion
type: Class
subclass of: regulation of B cell tolerance induction
subclass of: regulation of B cell apoptotic process
subclass of: GO_1904748

negative regulation of B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion.
has exact synonym: down regulation of B cell deletion
has exact synonym: down-regulation of B cell deletion
has exact synonym: downregulation of B cell deletion
has exact synonym: negative regulation of B lymphocyte deletion
has exact synonym: negative regulation of B-cell deletion
has exact synonym: negative regulation of B-lymphocyte deletion
has related synonym: inhibition of B cell deletion
type: Class
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of B cell deletion
subclass of: negative regulation of B cell apoptotic process
subclass of: GO_1904746

positive regulation of B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell deletion.
has exact synonym: positive regulation of B lymphocyte deletion
has exact synonym: positive regulation of B-cell deletion
has exact synonym: positive regulation of B-lymphocyte deletion
has exact synonym: up regulation of B cell deletion
has exact synonym: up-regulation of B cell deletion
has exact synonym: upregulation of B cell deletion
has related synonym: activation of B cell deletion
has related synonym: stimulation of B cell deletion
type: Class
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of B cell deletion
subclass of: positive regulation of B cell apoptotic process
subclass of: GO_1904747

T cell anergy
IAO_0000115: Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction.
has exact synonym: T lymphocyte anergy
has exact synonym: T-cell anergy
has exact synonym: T-lymphocyte anergy
type: Class
subclass of: lymphocyte anergy
subclass of: T cell tolerance induction

regulation of natural killer cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: regulation of NK cell tolerance induction
type: Class
subclass of: regulation of tolerance induction

negative regulation of natural killer cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: down regulation of natural killer cell tolerance induction
has exact synonym: down-regulation of natural killer cell tolerance induction
has exact synonym: downregulation of natural killer cell tolerance induction
has exact synonym: negative regulation of NK cell tolerance induction
has related synonym: inhibition of natural killer cell tolerance induction
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of natural killer cell tolerance induction

positive regulation of natural killer cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction.
has exact synonym: positive regulation of NK cell tolerance induction
has exact synonym: up regulation of natural killer cell tolerance induction
has exact synonym: up-regulation of natural killer cell tolerance induction
has exact synonym: upregulation of natural killer cell tolerance induction
has related synonym: activation of natural killer cell tolerance induction
has related synonym: stimulation of natural killer cell tolerance induction
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of acute inflammatory response
subclass of: regulation of natural killer cell tolerance induction

regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
type: Class
subclass of: regulation of chronic inflammatory response
subclass of: regulation of inflammatory response to antigenic stimulus

negative regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has exact synonym: down regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: down-regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: downregulation of chronic inflammatory response to antigenic stimulus
has related synonym: inhibition of chronic inflammatory response to antigenic stimulus
type: Class
subclass of: negative regulation of chronic inflammatory response
subclass of: negative regulation of inflammatory response to antigenic stimulus
subclass of: regulation of chronic inflammatory response to antigenic stimulus

positive regulation of chronic inflammatory response to antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.
has exact synonym: up regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: up-regulation of chronic inflammatory response to antigenic stimulus
has exact synonym: upregulation of chronic inflammatory response to antigenic stimulus
has related synonym: activation of chronic inflammatory response to antigenic stimulus
has related synonym: stimulation of chronic inflammatory response to antigenic stimulus
type: Class
subclass of: positive regulation of chronic inflammatory response
subclass of: positive regulation of inflammatory response to antigenic stimulus
subclass of: regulation of chronic inflammatory response to antigenic stimulus

regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
type: Class
subclass of: regulation of acute inflammatory response

negative regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has exact synonym: down regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: down-regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: downregulation of acute inflammatory response to non-antigenic stimulus
has related synonym: inhibition of acute inflammatory response to non-antigenic stimulus
type: Class
subclass of: negative regulation of acute inflammatory response
subclass of: regulation of acute inflammatory response to non-antigenic stimulus

positive regulation of acute inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.
has exact synonym: up regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: up-regulation of acute inflammatory response to non-antigenic stimulus
has exact synonym: upregulation of acute inflammatory response to non-antigenic stimulus
has related synonym: activation of acute inflammatory response to non-antigenic stimulus
has related synonym: stimulation of acute inflammatory response to non-antigenic stimulus
type: Class
subclass of: positive regulation of acute inflammatory response
subclass of: regulation of acute inflammatory response to non-antigenic stimulus

regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
type: Class
subclass of: regulation of chronic inflammatory response

negative regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has exact synonym: down regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: down-regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: downregulation of chronic inflammatory response to non-antigenic stimulus
has related synonym: inhibition of chronic inflammatory response to non-antigenic stimulus
type: Class
subclass of: negative regulation of chronic inflammatory response
subclass of: regulation of chronic inflammatory response to non-antigenic stimulus

positive regulation of chronic inflammatory response to non-antigenic stimulus
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.
has exact synonym: up regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: up-regulation of chronic inflammatory response to non-antigenic stimulus
has exact synonym: upregulation of chronic inflammatory response to non-antigenic stimulus
has related synonym: activation of chronic inflammatory response to non-antigenic stimulus
has related synonym: stimulation of chronic inflammatory response to non-antigenic stimulus
type: Class
subclass of: positive regulation of chronic inflammatory response
subclass of: regulation of chronic inflammatory response to non-antigenic stimulus

regulation of hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of hypersensitivity.
type: Class
subclass of: regulation of acute inflammatory response to antigenic stimulus

negative regulation of hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.
has exact synonym: down regulation of hypersensitivity
has exact synonym: down-regulation of hypersensitivity
has exact synonym: downregulation of hypersensitivity
has related synonym: inhibition of hypersensitivity
type: Class
subclass of: negative regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity

positive regulation of hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.
has exact synonym: up regulation of hypersensitivity
has exact synonym: up-regulation of hypersensitivity
has exact synonym: upregulation of hypersensitivity
has related synonym: activation of hypersensitivity
has related synonym: stimulation of hypersensitivity
type: Class
subclass of: positive regulation of acute inflammatory response to antigenic stimulus
subclass of: regulation of hypersensitivity

regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.
type: Class
subclass of: regulation of leukocyte mediated immunity

negative regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has exact synonym: down regulation of myeloid leukocyte mediated immunity
has exact synonym: down-regulation of myeloid leukocyte mediated immunity
has exact synonym: downregulation of myeloid leukocyte mediated immunity
has related synonym: inhibition of myeloid leukocyte mediated immunity
type: Class
subclass of: negative regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity

positive regulation of myeloid leukocyte mediated immunity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
has exact synonym: up regulation of myeloid leukocyte mediated immunity
has exact synonym: up-regulation of myeloid leukocyte mediated immunity
has exact synonym: upregulation of myeloid leukocyte mediated immunity
has related synonym: activation of myeloid leukocyte mediated immunity
has related synonym: stimulation of myeloid leukocyte mediated immunity
type: Class
subclass of: positive regulation of leukocyte mediated immunity
subclass of: regulation of myeloid leukocyte mediated immunity

regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.
type: Class
subclass of: regulation of B cell mediated immunity

negative regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.
has exact synonym: down regulation of immunoglobulin mediated immune response
has exact synonym: down-regulation of immunoglobulin mediated immune response
has exact synonym: downregulation of immunoglobulin mediated immune response
has related synonym: inhibition of immunoglobulin mediated immune response
type: Class
subclass of: negative regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response

positive regulation of immunoglobulin mediated immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
has exact synonym: up regulation of immunoglobulin mediated immune response
has exact synonym: up-regulation of immunoglobulin mediated immune response
has exact synonym: upregulation of immunoglobulin mediated immune response
has related synonym: activation of immunoglobulin mediated immune response
has related synonym: stimulation of immunoglobulin mediated immune response
type: Class
subclass of: positive regulation of B cell mediated immunity
subclass of: regulation of immunoglobulin mediated immune response

regulation of type II hypersensitivity
IAO_0000115: Any process that modulates the frequency, rate, or extent of type II hypersensitivity.
type: Class
subclass of: regulation of hypersensitivity
subclass of: regulation of myeloid leukocyte mediated immunity
subclass of: regulation of immunoglobulin mediated immune response

negative regulation of type II hypersensitivity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.
has exact synonym: down regulation of type II hypersensitivity
has exact synonym: down-regulation of type II hypersensitivity
has exact synonym: downregulation of type II hypersensitivity
has related synonym: inhibition of type II hypersensitivity
type: Class
subclass of: negative regulation of hypersensitivity
subclass of: negative regulation of myeloid leukocyte mediated immunity
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity

positive regulation of type II hypersensitivity
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.
has exact synonym: up regulation of type II hypersensitivity
has exact synonym: up-regulation of type II hypersensitivity
has exact synonym: upregulation of type II hypersensitivity
has related synonym: activation of type II hypersensitivity
has related synonym: stimulation of type II hypersensitivity
type: Class
subclass of: positive regulation of hypersensitivity
subclass of: positive regulation of myeloid leukocyte mediated immunity
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: regulation of type II hypersensitivity

regulation of central B cell tolerance induction
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell tolerance induction.
type: Class
subclass of: regulation of central tolerance induction
subclass of: regulation of B cell tolerance induction

negative regulation of central B cell tolerance induction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction.
has exact synonym: down regulation of central B cell tolerance induction
has exact synonym: down-regulation of central B cell tolerance induction
has exact synonym: downregulation of central B cell tolerance induction
has related synonym: inhibition of central B cell tolerance induction
type: Class
subclass of: negative regulation of central tolerance induction
subclass of: negative regulation of B cell tolerance induction
subclass of: regulation of central B cell tolerance induction

positive regulation of central B cell tolerance induction
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction.
has exact synonym: up regulation of central B cell tolerance induction
has exact synonym: up-regulation of central B cell tolerance induction
has exact synonym: upregulation of central B cell tolerance induction
has related synonym: activation of central B cell tolerance induction
has related synonym: stimulation of central B cell tolerance induction
type: Class
subclass of: positive regulation of central tolerance induction
subclass of: positive regulation of B cell tolerance induction
subclass of: regulation of central B cell tolerance induction

regulation of central B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell deletion.
type: Class
subclass of: regulation of B cell deletion
subclass of: regulation of central B cell tolerance induction
subclass of: GO_0045577

negative regulation of central B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion.
has exact synonym: down regulation of central B cell deletion
has exact synonym: down-regulation of central B cell deletion
has exact synonym: downregulation of central B cell deletion
has related synonym: inhibition of central B cell deletion
type: Class
subclass of: negative regulation of B cell deletion
subclass of: negative regulation of central B cell tolerance induction
subclass of: regulation of central B cell deletion
subclass of: GO_0045578

positive regulation of central B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell deletion.
has exact synonym: up regulation of central B cell deletion
has exact synonym: up-regulation of central B cell deletion
has exact synonym: upregulation of central B cell deletion
has related synonym: activation of central B cell deletion
has related synonym: stimulation of central B cell deletion
type: Class
subclass of: positive regulation of B cell deletion
subclass of: positive regulation of central B cell tolerance induction
subclass of: regulation of central B cell deletion
subclass of: GO_0045579

mature B cell apoptotic process
IAO_0000115: Any apoptotic process in a B cell that is mature, having left the bone marrow.
has exact synonym: apoptosis of mature B cells
has exact synonym: apoptosis of mature B lymphocytes
has exact synonym: apoptosis of mature B-cells
has exact synonym: apoptosis of mature B-lymphocytes
has exact synonym: mature B cell programmed cell death by apoptosis
has exact synonym: mature B lymphocyte apoptosis
has exact synonym: mature B lymphocyte programmed cell death by apoptosis
has exact synonym: mature B-cell apoptosis
has exact synonym: mature B-cell programmed cell death by apoptosis
has exact synonym: mature B-lymphocyte apoptosis
has exact synonym: mature B-lymphocyte programmed cell death by apoptosis
has exact synonym: programmed cell death of mature B cells by apoptosis
has exact synonym: programmed cell death of mature B lymphocytes by apoptosis
has exact synonym: programmed cell death of mature B-cells by apoptosis
has exact synonym: programmed cell death of mature B-lymphocytes by apoptosis
has exact synonym: programmed cell death, mature B cells
has exact synonym: programmed cell death, mature B lymphocytes
has exact synonym: programmed cell death, mature B-cells
has exact synonym: programmed cell death, mature B-lymphocytes
has related synonym: mature B cell apoptosis
type: Class
subclass of: B cell apoptotic process
subclass of: part-of-parent-1782

regulation of B cell apoptotic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of B cell apoptotic process.
has related synonym: regulation of B cell apoptosis
type: Class
subclass of: GO_0070228

negative regulation of B cell apoptotic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
has exact synonym: down regulation of B cell apoptosis
has exact synonym: down-regulation of B cell apoptosis
has exact synonym: downregulation of B cell apoptosis
has related synonym: inhibition of B cell apoptosis
has related synonym: negative regulation of B cell apoptosis
type: Class
subclass of: regulation of B cell apoptotic process
subclass of: GO_0070229

positive regulation of B cell apoptotic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.
has exact synonym: up regulation of B cell apoptosis
has exact synonym: up-regulation of B cell apoptosis
has exact synonym: upregulation of B cell apoptosis
has related synonym: activation of B cell apoptosis
has related synonym: positive regulation of B cell apoptosis
has related synonym: stimulation of B cell apoptosis
type: Class
subclass of: regulation of B cell apoptotic process
subclass of: GO_0070230

regulation of mature B cell apoptotic process
IAO_0000115: Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process.
has related synonym: regulation of mature B cell apoptosis
type: Class
subclass of: regulation of immune system process
subclass of: regulation of B cell apoptotic process
subclass of: GO_0065008

negative regulation of mature B cell apoptotic process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process.
has exact synonym: down regulation of mature B cell apoptosis
has exact synonym: down-regulation of mature B cell apoptosis
has exact synonym: downregulation of mature B cell apoptosis
has related synonym: inhibition of mature B cell apoptosis
has related synonym: negative regulation of mature B cell apoptosis
type: Class
subclass of: negative regulation of immune system process
subclass of: negative regulation of B cell apoptotic process
subclass of: regulation of mature B cell apoptotic process

positive regulation of mature B cell apoptotic process
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process.
has exact synonym: up regulation of mature B cell apoptosis
has exact synonym: up-regulation of mature B cell apoptosis
has exact synonym: upregulation of mature B cell apoptosis
has related synonym: activation of mature B cell apoptosis
has related synonym: positive regulation of mature B cell apoptosis
has related synonym: stimulation of mature B cell apoptosis
type: Class
subclass of: positive regulation of immune system process
subclass of: positive regulation of B cell apoptotic process
subclass of: regulation of mature B cell apoptotic process

regulation of peripheral B cell deletion
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral B cell deletion.
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of B cell mediated immunity
subclass of: regulation of B cell deletion

negative regulation of peripheral B cell deletion
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion.
has exact synonym: down regulation of peripheral B cell deletion
has exact synonym: down-regulation of peripheral B cell deletion
has exact synonym: downregulation of peripheral B cell deletion
has related synonym: inhibition of peripheral B cell deletion
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of B cell mediated immunity
subclass of: negative regulation of B cell deletion
subclass of: regulation of peripheral B cell deletion

positive regulation of peripheral B cell deletion
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion.
has exact synonym: up regulation of peripheral B cell deletion
has exact synonym: up-regulation of peripheral B cell deletion
has exact synonym: upregulation of peripheral B cell deletion
has related synonym: activation of peripheral B cell deletion
has related synonym: stimulation of peripheral B cell deletion
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of B cell mediated immunity
subclass of: positive regulation of B cell deletion
subclass of: regulation of peripheral B cell deletion

regulation of lymphocyte anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of lymphocyte anergy.
type: Class
subclass of: regulation of tolerance induction

negative regulation of lymphocyte anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy.
has exact synonym: down regulation of lymphocyte anergy
has exact synonym: down-regulation of lymphocyte anergy
has exact synonym: downregulation of lymphocyte anergy
has related synonym: inhibition of lymphocyte anergy
type: Class
subclass of: negative regulation of tolerance induction
subclass of: regulation of lymphocyte anergy

positive regulation of lymphocyte anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy.
has exact synonym: up regulation of lymphocyte anergy
has exact synonym: up-regulation of lymphocyte anergy
has exact synonym: upregulation of lymphocyte anergy
has related synonym: activation of lymphocyte anergy
has related synonym: stimulation of lymphocyte anergy
type: Class
subclass of: positive regulation of tolerance induction
subclass of: regulation of lymphocyte anergy

regulation of central B cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of central B cell anergy.
type: Class
subclass of: regulation of B cell anergy
subclass of: regulation of central B cell tolerance induction
subclass of: GO_0045577

negative regulation of central B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy.
has exact synonym: down regulation of central B cell anergy
has exact synonym: down-regulation of central B cell anergy
has exact synonym: downregulation of central B cell anergy
has related synonym: inhibition of central B cell anergy
type: Class
subclass of: negative regulation of B cell anergy
subclass of: negative regulation of central B cell tolerance induction
subclass of: regulation of central B cell anergy
subclass of: GO_0045578

positive regulation of central B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of central B cell anergy.
has exact synonym: up regulation of central B cell anergy
has exact synonym: up-regulation of central B cell anergy
has exact synonym: upregulation of central B cell anergy
has related synonym: activation of central B cell anergy
has related synonym: stimulation of central B cell anergy
type: Class
subclass of: positive regulation of B cell anergy
subclass of: positive regulation of central B cell tolerance induction
subclass of: regulation of central B cell anergy
subclass of: GO_0045579

regulation of peripheral B cell anergy
IAO_0000115: Any process that modulates the frequency, rate, or extent of peripheral B cell anergy.
type: Class
subclass of: regulation of peripheral tolerance induction
subclass of: regulation of B cell anergy
subclass of: regulation of B cell mediated immunity

negative regulation of peripheral B cell anergy
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy.
has exact synonym: down regulation of peripheral B cell anergy
has exact synonym: down-regulation of peripheral B cell anergy
has exact synonym: downregulation of peripheral B cell anergy
has related synonym: inhibition of peripheral B cell anergy
type: Class
subclass of: negative regulation of peripheral tolerance induction
subclass of: negative regulation of B cell anergy
subclass of: negative regulation of B cell mediated immunity
subclass of: regulation of peripheral B cell anergy

positive regulation of peripheral B cell anergy
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy.
has exact synonym: up regulation of peripheral B cell anergy
has exact synonym: up-regulation of peripheral B cell anergy
has exact synonym: upregulation of peripheral B cell anergy
has related synonym: activation of peripheral B cell anergy
has related synonym: stimulation of peripheral B cell anergy
type: Class
subclass of: positive regulation of peripheral tolerance induction
subclass of: positive regulation of B cell anergy
subclass of: positive regulation of B cell mediated immunity
subclass of: regulation of peripheral B cell anergy

regulation of humoral immune response
IAO_0000115: Any process that modulates the frequency, rate, or extent of a humoral immune response.
type: Class
subclass of: GO_0050776

negative regulation of humoral immune response
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.
has exact synonym: down regulation of humoral immune response
has exact synonym: down-regulation of humoral immune response
has exact synonym: downregulation of humoral immune response
has related synonym: inhibition of humoral immune response
type: Class
subclass of: regulation of humoral immune response
subclass of: GO_0050777

positive regulation of humoral immune response
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a humoral immune response.
has exact synonym: up regulation of humoral immune response
has exact synonym: up-regulation of humoral immune response
has exact synonym: upregulation of humoral immune response
has related synonym: activation of humoral immune response
has related synonym: stimulation of humoral immune response
type: Class
subclass of: regulation of humoral immune response
subclass of: GO_0050778

regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
type: Class
subclass of: regulation of immunoglobulin mediated immune response
subclass of: regulation of humoral immune response

negative regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has exact synonym: down regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: down-regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: downregulation of humoral immune response mediated by circulating immunoglobulin
has related synonym: inhibition of humoral immune response mediated by circulating immunoglobulin
type: Class
subclass of: negative regulation of immunoglobulin mediated immune response
subclass of: negative regulation of humoral immune response
subclass of: regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response mediated by circulating immunoglobulin
IAO_0000115: Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.
has exact synonym: up regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: up-regulation of humoral immune response mediated by circulating immunoglobulin
has exact synonym: upregulation of humoral immune response mediated by circulating immunoglobulin
has related synonym: activation of humoral immune response mediated by circulating immunoglobulin
has related synonym: stimulation of humoral immune response mediated by circulating immunoglobulin
type: Class
subclass of: positive regulation of immunoglobulin mediated immune response
subclass of: positive regulation of humoral immune response
subclass of: regulation of humoral immune response mediated by circulating immunoglobulin

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
IAO_0000115: The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
has exact synonym: mcm5 modification
has exact synonym: mcm5s2U34 biosynthesis
has exact synonym: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis
type: Class
subclass of: tRNA wobble uridine modification

archaeosine-tRNA biosynthetic process
IAO_0000115: The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs.
type: Class
subclass of: GO_0006400
subclass of: GO_0009058

MECO complex
IAO_0000115: A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.
has exact synonym: meta-coactivator complex
type: Class
subclass of: GO_0032991

trabecular meshwork development
IAO_0000115: The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.
type: Class
subclass of: part-of-parent-43010
subclass of: GO_0009888

response to ischemia
IAO_0000115: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
type: Class
subclass of: GO_0006950

tendon sheath development
IAO_0000115: The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.
type: Class
subclass of: part-of-parent-35989
subclass of: GO_0061448

lipid hydroxylation
IAO_0000115: The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
has related synonym: fatty acid hydroxylation
type: Class
subclass of: GO_0030258

desmosome organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
type: Class
subclass of: GO_0045216

tRNA (adenine-C2-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA.
type: Class
subclass of: GO_0008169
subclass of: GO_0016426

bradykinin biosynthetic process
IAO_0000115: The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin.
type: Class
subclass of: GO_0043043

tRNA 4-thiouridine biosynthesis
IAO_0000115: The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs.
type: Class
subclass of: GO_0034227

tRNA guanine ribose methylation
IAO_0000115: The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety.
type: Class
subclass of: tRNA nucleoside ribose methylation

tRNA N1-guanine methylation
IAO_0000115: The process whereby a guanine in tRNA is methylated at position N1 of the guanine.
has related synonym: tRNA m1-guanine biosynthesis
type: Class
subclass of: GO_0030488

tRNA N2-guanine methylation
IAO_0000115: The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.
has related synonym: tRNA m2-guanine biosynthesis
type: Class
subclass of: GO_0030488

synoviocyte proliferation
IAO_0000115: The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues.
type: Class
subclass of: GO_0008283

tRNA m2,2-guanine biosynthesis
IAO_0000115: The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position.
type: Class
subclass of: GO_0030488

tRNA dihydrouridine synthesis
IAO_0000115: The process whereby a uridine in a transfer RNA is converted to dihydrouridine.
type: Class
subclass of: GO_0006400

cyclin K-CDK12 complex
IAO_0000115: A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
has related synonym: CycK/Cdk12 complex
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex

cyclin K-CDK13 complex
IAO_0000115: A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
has related synonym: CycK/Cdk13 complex
type: Class
subclass of: cyclin-dependent protein kinase holoenzyme complex

tRNA C5-cytosine methylation
IAO_0000115: The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine.
has related synonym: tRNA 5-methylcytosine biosynthesis
type: Class
subclass of: GO_0030488

tumor necrosis factor receptor superfamily complex
IAO_0000115: A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.
has related synonym: TNF receptor superfamily complex
type: Class
subclass of: GO_0043235

archaeosine synthase activity
IAO_0000115: Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA.
has related synonym: ArcS
has related synonym: glutamine:preQ0-tRNA amidinotransferase
type: Class
subclass of: GO_0015067

tRNA threonylcarbamoyladenosine modification
IAO_0000115: The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base).
has exact synonym: t6A biosynthesis
has exact synonym: t6A biosynthetic process
has exact synonym: t6A tRNA modification
has exact synonym: threonylcarbamoyladenosine anabolism
has exact synonym: threonylcarbamoyladenosine biosynthesis
has exact synonym: threonylcarbamoyladenosine biosynthetic process
has exact synonym: threonylcarbamoyladenosine formation
has exact synonym: threonylcarbamoyladenosine synthesis
replaces: GO_0070526
type: Class
subclass of: GO_0006400
subclass of: GO_0070525

ceramide phosphoethanolamine synthase activity
IAO_0000115: Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine.
type: Class
subclass of: GO_0016780

leukotriene-C(4) hydrolase
IAO_0000115: Catalysis of the reaction Leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate.
type: Class
subclass of: GO_0070122

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IAO_0000115: Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione.
has related synonym: phospho-AI-2 isomerase activity
type: Class
subclass of: GO_0016853

5'-deoxynucleotidase activity
IAO_0000115: Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate.
type: Class
subclass of: GO_0016791

obsolete generation of a signal involved in cell-cell signaling
IAO_0000115: OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
type: Class
subclass of: ObsoleteClass

regionalization
IAO_0000115: The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
has related synonym: pattern formation
type: Class
subclass of: GO_0007389

follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
IAO_0000115: The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis.
has related synonym: follicular fluid formation in ovarian follicle antrum during fused antrum stage
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: part-of-parent-48165

follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
IAO_0000115: The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis.
has related synonym: follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: part-of-parent-48164

follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
IAO_0000115: The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis.
has related synonym: follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage
type: Class
subclass of: follicular fluid formation in ovarian follicle antrum
subclass of: part-of-parent-48163

developmental process involved in reproduction
IAO_0000115: A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
has related synonym: puberty
has related synonym: reproductive developmental process
type: Class
subclass of: part-of-parent-3
subclass of: GO_0022414
subclass of: GO_0032502

heart morphogenesis
IAO_0000115: The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
has related synonym: cardiac morphogenesis
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0009887

system process
IAO_0000115: A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
has exact synonym: organ system process
type: Class
subclass of: GO_0032501

skeletal muscle contraction
IAO_0000115: A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
type: Class
subclass of: part-of-parent-50881
subclass of: GO_0006941

voluntary skeletal muscle contraction
IAO_0000115: A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.
type: Class
subclass of: skeletal muscle contraction

involuntary skeletal muscle contraction
IAO_0000115: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control.
type: Class
subclass of: skeletal muscle contraction

muscle system process
IAO_0000115: A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
has related synonym: muscle physiological process
type: Class
subclass of: system process

circulatory system process
IAO_0000115: A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
type: Class
subclass of: system process

renal system process
IAO_0000115: A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
has exact synonym: excretory system process
has related synonym: kidney system process
type: Class
subclass of: system process

heart process
IAO_0000115: A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
has related synonym: cardiac process
type: Class
subclass of: circulatory system process

respiratory system process
IAO_0000115: A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
has exact synonym: respiratory gaseous exchange
replaces: GO_0010802
type: Class
subclass of: system process
subclass of: part-of-parent-7585

lymph circulation
IAO_0000115: The flow of lymph through the body of an animal.
type: Class
subclass of: circulatory system process

vascular process in circulatory system
IAO_0000115: A circulatory process that occurs at the level of the vasculature.
has exact synonym: vasculature process
type: Class
subclass of: circulatory system process

central nervous system control of baroreceptor feedback
IAO_0000115: The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris.
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-1978

detection of reduced oxygen by chemoreceptor signaling
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of reduced oxygen by chemoreceptor signalling
type: Class
subclass of: part-of-parent-2007
subclass of: GO_0070483

detection of increased carbon dioxide by chemoreceptor signaling
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.
has exact synonym: detection of increased carbon dioxide by chemoreceptor signalling
type: Class
subclass of: part-of-parent-2007
subclass of: detection of carbon dioxide

detection of pH by chemoreceptor signaling
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors.
has exact synonym: detection of pH by chemoreceptor signalling
type: Class
subclass of: detection of hydrogen ion

baroreceptor detection of increased arterial stretch
IAO_0000115: The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal.
type: Class
subclass of: baroreceptor detection of arterial stretch
subclass of: part-of-parent-1983

baroreceptor detection of decreased arterial stretch
IAO_0000115: The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal.
type: Class
subclass of: baroreceptor detection of arterial stretch
subclass of: part-of-parent-1982

regulation of systemic arterial blood pressure by baroreceptor feedback
IAO_0000115: The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.
has exact synonym: baroreceptor regulation of systemic arterial blood pressure
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
IAO_0000115: The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.
has exact synonym: aortic arch baroreceptor control of systemic arterial blood pressure
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: part-of-parent-3025

regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: carotid body chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: carotid body chemoreceptor response to lowering of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling
has related synonym: vagal reflex
type: Class
subclass of: regulation of systemic arterial blood pressure by chemoreceptor signaling

regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
IAO_0000115: The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.
has exact synonym: aortic body chemoreceptor regulation of systemic arterial blood pressure
has exact synonym: aortic body chemoreceptor response to lowering of systemic arterial blood pressure
has exact synonym: regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling
type: Class
subclass of: regulation of systemic arterial blood pressure by chemoreceptor signaling

detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies.
has exact synonym: detection of hypoxic conditions in blood by carotid body chemoreceptor signalling
type: Class
subclass of: detection of hypoxic conditions in blood by chemoreceptor signaling
subclass of: part-of-parent-3027

detection of hydrogen ion
IAO_0000115: The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal.
type: Class
subclass of: GO_0009593

detection of carbon dioxide
IAO_0000115: The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal.
type: Class
subclass of: GO_0009593

detection of oxygen
IAO_0000115: The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.
type: Class
subclass of: GO_0009593
subclass of: GO_0070482

detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies.
has exact synonym: detection of hypoxic conditions in blood by aortic body chemoreceptor signalling
type: Class
subclass of: detection of hypoxic conditions in blood by chemoreceptor signaling
subclass of: part-of-parent-3028

detection of increased carbon dioxide by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of increased carbon dioxide by aortic body chemoreceptor signalling
type: Class
subclass of: detection of increased carbon dioxide by chemoreceptor signaling
subclass of: part-of-parent-3033

detection of increased carbon dioxide by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of increased carbon dioxide by carotid body chemoreceptor signalling
type: Class
subclass of: detection of increased carbon dioxide by chemoreceptor signaling
subclass of: part-of-parent-3029

detection of pH by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of pH by aortic body chemoreceptor signalling
type: Class
subclass of: detection of pH by chemoreceptor signaling
subclass of: part-of-parent-3033

detection of pH by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of pH by carotid body chemoreceptor signalling
type: Class
subclass of: detection of pH by chemoreceptor signaling
subclass of: part-of-parent-3029

detection of reduced oxygen by aortic body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body.
has exact synonym: detection of reduced oxygen by aortic body chemoreceptor signalling
type: Class
subclass of: detection of reduced oxygen by chemoreceptor signaling
subclass of: part-of-parent-3033

detection of reduced oxygen by carotid body chemoreceptor signaling
IAO_0000115: The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body.
has exact synonym: detection of reduced oxygen by carotid body chemoreceptor signalling
type: Class
subclass of: detection of reduced oxygen by chemoreceptor signaling
subclass of: part-of-parent-3029

excitation of vasomotor center by aortic body chemoreceptor signaling
IAO_0000115: The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by aortic body chemoreceptor signalling
type: Class
subclass of: excitation of vasomotor center by chemoreceptor signaling
subclass of: part-of-parent-3028

excitation of vasomotor center by carotid body chemoreceptor signaling
IAO_0000115: The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.
has exact synonym: excitation of vasomotor center by carotid body chemoreceptor signalling
type: Class
subclass of: excitation of vasomotor center by chemoreceptor signaling
subclass of: part-of-parent-3027

vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has related synonym: vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure
type: Class
subclass of: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
subclass of: part-of-parent-3027

vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure
IAO_0000115: A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.
has related synonym: vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure
type: Class
subclass of: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
subclass of: part-of-parent-3028

regulation of systemic arterial blood pressure mediated by a chemical signal
IAO_0000115: The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.
has exact synonym: blood pressure regulation mediated by a chemical signal
type: Class
subclass of: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by physical factors
IAO_0000115: The regulation of blood pressure mediated by detection of forces within the circulatory system.
has exact synonym: blood pressure regulation by physical factors
type: Class
subclass of: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by stress relaxation
IAO_0000115: The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs.
has exact synonym: blood pressure regulation by stress relaxation
type: Class
subclass of: regulation of systemic arterial blood pressure by physical factors
subclass of: negative regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by epinephrine
IAO_0000115: The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine.
has exact synonym: regulation of blood pressure by adrenaline
has related synonym: blood pressure regulation by epinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: part-of-parent-1993

regulation of systemic arterial blood pressure by norepinephrine
IAO_0000115: The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.
has exact synonym: regulation of blood pressure by noradrenaline
has related synonym: blood pressure regulation by norepinephrine
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: part-of-parent-1993

regulation of systemic arterial blood pressure by capillary fluid shift
IAO_0000115: The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment.
has exact synonym: blood pressure regulation by capillary fluid shift
type: Class
subclass of: regulation of systemic arterial blood pressure by physical factors

regulation of systemic arterial blood pressure by atrial natriuretic peptide
IAO_0000115: The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
has exact synonym: blood pressure regulation by atrial natriuretic peptide
has related synonym: blood pressure regulation by ANP
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

angiotensin-mediated drinking behavior
IAO_0000115: The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.
has exact synonym: angiotensin mediated drinking behavior
type: Class
subclass of: part-of-parent-2035
subclass of: GO_0042756

circadian regulation of systemic arterial blood pressure
IAO_0000115: Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours.
type: Class
subclass of: regulation of systemic arterial blood pressure
subclass of: GO_0007623

circadian regulation of heart rate
IAO_0000115: Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours.
has related synonym: circadian regulation of heart contraction rate
type: Class
subclass of: regulation of heart rate
subclass of: GO_0007623
subclass of: GO_0032501

circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
IAO_0000115: The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours.
has exact synonym: SCN regulation of blood pressure
has exact synonym: master pacemaker clock regulation of blood pressure
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: circadian regulation of systemic arterial blood pressure

circadian regulation of heart rate by the suprachiasmatic nucleus
IAO_0000115: The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours.
has exact synonym: SCN regulation of heart rate
has exact synonym: master pacemaker clock regulation of heart rate
has related synonym: circadian regulation of heart contraction rate by the suprachiasmatic nucleus
type: Class
subclass of: circadian regulation of heart rate

regulation of vascular associated smooth muscle contraction
IAO_0000115: Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.
has exact synonym: regulation of vascular smooth muscle contraction
type: Class
subclass of: GO_0006940
subclass of: GO_0019229

regulation of the force of heart contraction by chemical signal
IAO_0000115: The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: chemical cardiac inotropy
has related synonym: regulation of the force of heart muscle contraction by chemical signal
type: Class
subclass of: regulation of the force of heart contraction

hormonal regulation of the force of heart contraction
IAO_0000115: The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: hormonal cardiac inotropy
has related synonym: hormonal regulation of the force of heart muscle contraction
type: Class
subclass of: regulation of the force of heart contraction by chemical signal

positive regulation of the force of heart contraction by epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction.
has exact synonym: adrenaline cardiac inotropy
has exact synonym: adrenaline regulation of the strength of heart muscle contraction
has exact synonym: epinephrine cardiac inotropy
has exact synonym: increased force of heart contraction by epinephrine
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by epinephrine
type: Class
subclass of: part-of-parent-1997
subclass of: positive regulation of the force of heart contraction by chemical signal

negative regulation of the force of heart contraction by acetylcholine
IAO_0000115: The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction.
has exact synonym: decreased force of heart contraction by acetylcholine
type: Class
subclass of: part-of-parent-3068
subclass of: negative regulation of the force of heart contraction by chemical signal

positive regulation of the force of heart contraction by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction.
has exact synonym: increased force of heart contraction by norepinephrine
has exact synonym: noradrenaline cardiac inotropy
has exact synonym: noradrenaline regulation of the strength of heart muscle contraction
has exact synonym: norepinephrine cardiac inotropy
has related synonym: increased force of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by norepinephrine
type: Class
subclass of: part-of-parent-1997
subclass of: positive regulation of the force of heart contraction by chemical signal

regulation of heart rate by chemical signal
IAO_0000115: The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: chemical cardiac chronotropy
has exact synonym: chemical signal regulation of heart rate
has related synonym: chemical signal regulation of heart contraction rate
type: Class
subclass of: regulation of heart rate

negative regulation of heart rate by acetylcholine
IAO_0000115: The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction.
has related synonym: negative regulation of heart contraction rate by acetylcholine
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: part-of-parent-3068
subclass of: GO_0010459

regulation of heart rate by hormone
IAO_0000115: The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
has exact synonym: hormonal cardiac chronotropy
has exact synonym: regulation of the rate of heart contraction by hormone
type: Class
subclass of: regulation of heart rate by chemical signal

positive regulation of heart rate by epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: adrenaline cardiac chronotropy
has exact synonym: adrenaline regulation of the rate of heart muscle contraction
has exact synonym: epinephrine cardiac chronotropy
has related synonym: positive regulation of heart contraction rate by epinephrine
has related synonym: positive regulation of heart rate by adrenaline
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: part-of-parent-1996
subclass of: GO_0010460

positive regulation of heart rate by norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: noradrenaline cardiac chronotropy
has exact synonym: noradrenaline regulation of the rate of heart muscle contraction
has exact synonym: norepinephrine cardiac chronotropy
has exact synonym: positive regulation of heart rate by adrenaline
has related synonym: positive regulation of heart contraction rate by norepinephrine
type: Class
subclass of: regulation of heart rate by chemical signal
subclass of: part-of-parent-1996
subclass of: GO_0010460

circadian regulation of systemic arterial blood pressure by hormone
IAO_0000115: The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone
subclass of: part-of-parent-3052

regulation of systemic arterial blood pressure by acetylcholine
IAO_0000115: The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter.
has exact synonym: blood pressure regulation by acetylcholine
type: Class
subclass of: regulation of systemic arterial blood pressure by neurotransmitter

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
IAO_0000115: The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.
has exact synonym: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
type: Class
subclass of: part-of-parent-3068
subclass of: negative regulation of systemic arterial blood pressure
subclass of: GO_0042311

regulation of systemic arterial blood pressure by neurotransmitter
IAO_0000115: The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
type: Class
subclass of: nervous system process involved in regulation of systemic arterial blood pressure
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal

renal system process involved in regulation of systemic arterial blood pressure
IAO_0000115: Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
has exact synonym: renal control of blood pressure
has exact synonym: renal regulation of systemic arterial blood pressure
type: Class
subclass of: renal system process
subclass of: part-of-parent-3073

renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
IAO_0000115: The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature.
has exact synonym: regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence
has exact synonym: renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence
type: Class
subclass of: renal system process involved in regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure
IAO_0000115: The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
type: Class
subclass of: GO_0008217

obsolete regulation of diuresis
IAO_0000115: OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.
type: Class
subclass of: ObsoleteClass

renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
IAO_0000115: The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system.
has exact synonym: renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system
type: Class
subclass of: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

obsolete negative regulation of diuresis
IAO_0000115: OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion.
type: Class
subclass of: ObsoleteClass

obsolete regulation of natriuresis
IAO_0000115: OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.
type: Class
subclass of: ObsoleteClass

obsolete positive regulation of natriuresis
IAO_0000115: OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis.
type: Class
subclass of: ObsoleteClass

obsolete negative regulation of natriuresis
IAO_0000115: OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.
type: Class
subclass of: ObsoleteClass

regulation of systemic arterial blood pressure by renin-angiotensin
IAO_0000115: The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
has exact synonym: blood pressure regulation by renin-angiotensin
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

obsolete positive regulation of renal output by angiotensin
IAO_0000115: OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney.
type: Class
subclass of: ObsoleteClass

negative regulation of renal output by angiotensin
IAO_0000115: The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney.
has exact synonym: angiotensin mediated negative regulation of renal output
has exact synonym: angiotensin-mediated negative regulation of renal output
type: Class
subclass of: regulation of renal output by angiotensin
subclass of: positive regulation of systemic arterial blood pressure

positive regulation of systemic arterial blood pressure
IAO_0000115: The process that increases the force with which blood travels through the systemic arterial circulatory system.
type: Class
subclass of: part-of-parent-3073
subclass of: GO_0045777

negative regulation of systemic arterial blood pressure
IAO_0000115: The process that reduces the force with which blood travels through the systemic arterial circulatory system.
type: Class
subclass of: part-of-parent-3073
subclass of: GO_0045776

regulation of systemic arterial blood pressure by local renal renin-angiotensin
IAO_0000115: The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen.
type: Class
subclass of: regulation of systemic arterial blood pressure by renin-angiotensin

positive regulation of the force of heart contraction by neuronal epinephrine
IAO_0000115: The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by epinephrine released from the nerve endings
has exact synonym: increased force of heart contraction by neuronal epinephrine
has related synonym: increased force of heart contraction by neuronal adrenaline
has related synonym: positive regulation of heart contraction by adrenaline
has related synonym: positive regulation of heart contraction by neuronal epinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine
subclass of: part-of-parent-3090

positive regulation of the force of heart contraction by circulating epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by epinephrine in the bloodstream
has related synonym: increased force of heart contraction by circulating adrenaline
has related synonym: positive regulation of heart contraction by circulating adrenaline
has related synonym: positive regulation of heart contraction by circulating epinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine
subclass of: part-of-parent-3089

positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream.
has exact synonym: increased force of heart contraction by circulating adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by circulating epinephrine-norepinephrine
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine in the blood stream
has related synonym: positive regulation of heart contraction by circulating adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by circulating epinephrine-norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
IAO_0000115: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings.
has exact synonym: increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings
has exact synonym: increased force of heart contraction by neuronal adrenaline-noradrenaline
has exact synonym: increased force of heart contraction by neuronal epinephrine-norepinephrine
has related synonym: positive regulation of heart contraction by adrenaline-noradrenaline
has related synonym: positive regulation of heart contraction by epinephrine-norepinephrine
type: Class
subclass of: positive regulation of the force of heart contraction by epinephrine-norepinephrine

renal water homeostasis
IAO_0000115: Renal process involved in the maintenance of an internal steady state of water in the body.
has exact synonym: water homeostasis by the renal system
type: Class
subclass of: renal system process
subclass of: GO_0050891

renal water retention
IAO_0000115: The process in which renal water excretion is decreased.
has exact synonym: negative regulation of renal water excretion
type: Class
subclass of: GO_0035811

regulation of glomerular filtration
IAO_0000115: Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: GO_0098801

glomerular filtration
IAO_0000115: The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
type: Class
subclass of: GO_0097205

pressure natriuresis
IAO_0000115: The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis).
type: Class
subclass of: renal system process involved in regulation of blood volume

renal sodium ion transport
IAO_0000115: The directed movement of sodium ions (Na+) by the renal system.
type: Class
subclass of: renal system process
subclass of: GO_0006814

renal water transport
IAO_0000115: The directed movement of water (H2O) by the renal system.
type: Class
subclass of: renal system process
subclass of: part-of-parent-3091
subclass of: GO_0006833

tubuloglomerular feedback
IAO_0000115: The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.
type: Class
subclass of: renal system process involved in regulation of blood volume
subclass of: part-of-parent-3093

positive regulation of the force of heart contraction by chemical signal
IAO_0000115: Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has exact synonym: positive regulation of the force of heart muscle contraction by chemical signal
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
subclass of: GO_0045823

regulation of systemic arterial blood pressure by endothelin
IAO_0000115: The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
IAO_0000115: The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system.
has related synonym: regulation of blood pressure by circulating adrenaline-noradrenaline
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

obsolete positive regulation of diuresis by angiotensin
IAO_0000115: OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis.
type: Class
subclass of: ObsoleteClass

obsolete positive regulation of diuresis
IAO_0000115: OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion.
type: Class
subclass of: ObsoleteClass

positive regulation of glomerular filtration
IAO_0000115: Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
type: Class
subclass of: regulation of glomerular filtration
subclass of: GO_0051240

negative regulation of glomerular filtration
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
type: Class
subclass of: regulation of glomerular filtration
subclass of: GO_0051241

negative regulation of glomerular filtration by angiotensin
IAO_0000115: The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
has related synonym: angiotensin-mediated regulation of glomerular filtration
has related synonym: regulation of glomerular filtration by angiotensin
type: Class
subclass of: negative regulation of renal output by angiotensin
subclass of: part-of-parent-3105

obsolete positive regulation of natriuresis by angiotensin
IAO_0000115: OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion.
type: Class
subclass of: ObsoleteClass

negative regulation of the force of heart contraction by chemical signal
IAO_0000115: Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
has related synonym: negative regulation of the force of heart muscle contraction by chemical signal
type: Class
subclass of: regulation of the force of heart contraction by chemical signal
subclass of: GO_0045822

positive regulation of the force of heart contraction by circulating norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by circulating norepinephrine
has related synonym: increased force of heart contraction by circulating noradrenaline
type: Class
subclass of: positive regulation of the force of heart contraction by norepinephrine

positive regulation of the force of heart contraction by neuronal norepinephrine
IAO_0000115: The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction.
has exact synonym: increased force of heart contraction by neuronal norepinephrine
has related synonym: increased force of heart contraction by neuronal noradrenaline
type: Class
subclass of: positive regulation of the force of heart contraction by norepinephrine

positive regulation of heart rate by circulating epinephrine
IAO_0000115: The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by circulating adrenaline
type: Class
subclass of: positive regulation of heart rate by epinephrine

positive regulation of heart rate by neuronal epinephrine
IAO_0000115: The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by neuronal adrenaline
type: Class
subclass of: positive regulation of heart rate by epinephrine

positive regulation of heart rate by neuronal norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by neuronal noradrenaline
type: Class
subclass of: positive regulation of heart rate by norepinephrine

positive regulation of heart rate by circulating norepinephrine
IAO_0000115: The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction.
has exact synonym: positive regulation of heart rate by circulating noradrenaline
type: Class
subclass of: positive regulation of heart rate by norepinephrine

regulation of vasoconstriction by epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings.
type: Class
subclass of: GO_0019229

regulation of vasoconstriction by norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings.
type: Class
subclass of: GO_0019229

regulation of vasoconstriction by circulating norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.
has exact synonym: regulation of vasoconstriction by circulating noradrenaline
type: Class
subclass of: regulation of vasoconstriction by norepinephrine

regulation of vasoconstriction by neuronal norepinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings.
has exact synonym: regulation of vasoconstriction by neuronal noradrenaline
type: Class
subclass of: regulation of vasoconstriction by norepinephrine

regulation of vasoconstriction by neuronal epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings.
has exact synonym: regulation of vasoconstriction by neuronal adrenaline
type: Class
subclass of: regulation of vasoconstriction by epinephrine

regulation of vasoconstriction by circulating epinephrine
IAO_0000115: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.
has exact synonym: regulation of vasoconstriction by circulating adrenaline
type: Class
subclass of: regulation of vasoconstriction by epinephrine

epinephrine-mediated vasodilation
IAO_0000115: A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings.
has related synonym: regulation of vasodilation by adrenaline
has related synonym: regulation of vasodilation by circulating adrenaline
has related synonym: regulation of vasodilation by circulating epinephrine
has related synonym: regulation of vasodilation by epinephrine
has related synonym: regulation of vasodilation by neuronal adrenaline
has related synonym: regulation of vasodilation by neuronal epinephrine
replaces: GO_0003123
replaces: GO_0003124
type: Class
subclass of: GO_0042311

norepinephrine-mediated vasodilation
IAO_0000115: A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings.
has related synonym: regulation of vasodilation by circulating noradrenaline
has related synonym: regulation of vasodilation by circulating norepinephrine
has related synonym: regulation of vasodilation by neuronal noradrenaline
has related synonym: regulation of vasodilation by neuronal norepinephrine
has related synonym: regulation of vasodilation by noradrenaline
has related synonym: regulation of vasodilation by norepinephrine
replaces: GO_0003125
replaces: GO_0003126
type: Class
subclass of: GO_0042311

detection of nodal flow
IAO_0000115: The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.
type: Class
subclass of: part-of-parent-7368
subclass of: GO_0009726

heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.
type: Class
subclass of: part-of-parent-60914
subclass of: GO_0010092

heart induction
IAO_0000115: The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.
type: Class
subclass of: organ induction
subclass of: GO_2000826

BMP signaling pathway involved in heart induction
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.
has exact synonym: BMP signalling pathway involved in heart induction
type: Class
subclass of: part-of-parent-3129
subclass of: part-of-parent-3134
subclass of: GO_0030509
subclass of: GO_1905114

mesodermal-endodermal cell signaling
IAO_0000115: Any process that mediates the transfer of information from mesodermal cells to endodermal cells.
has exact synonym: mesodermal-endodermal cell signalling
type: Class
subclass of: GO_0007267

mesodermal-endodermal cell signaling involved in heart induction
IAO_0000115: Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction.
has exact synonym: mesodermal-endodermal cell signalling involved in heart induction
type: Class
subclass of: mesodermal-endodermal cell signaling
subclass of: part-of-parent-3129

endodermal-mesodermal cell signaling
IAO_0000115: Any process that mediates the transfer of information from endodermal cells to mesodermal cells.
has exact synonym: endodermal-mesodermal cell signalling
type: Class
subclass of: GO_0007267

endodermal-mesodermal cell signaling involved in heart induction
IAO_0000115: Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction.
has exact synonym: endodermal-mesodermal cell signalling involved in heart induction
type: Class
subclass of: endodermal-mesodermal cell signaling
subclass of: part-of-parent-3129

fibroblast growth factor receptor signaling pathway involved in heart induction
IAO_0000115: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction.
has exact synonym: fibroblast growth factor receptor signalling pathway involved in heart induction
type: Class
subclass of: part-of-parent-3129
subclass of: GO_0008543

negative regulation of heart induction by canonical Wnt signaling pathway
IAO_0000115: Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction.
has exact synonym: negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt receptor signaling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt receptor signalling pathway
has exact synonym: negative regulation of heart induction by canonical Wnt-activated signaling pathway
type: Class
subclass of: GO_0009997
subclass of: GO_0061316
subclass of: GO_0100012
subclass of: GO_1901320

Notch signaling pathway involved in heart induction
IAO_0000115: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.
has exact synonym: Notch signalling pathway involved in heart induction
type: Class
subclass of: part-of-parent-3129
subclass of: GO_0007219

primary heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
has exact synonym: FHS specification
has exact synonym: first heart field specification
type: Class
subclass of: heart field specification

secondary heart field specification
IAO_0000115: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
has exact synonym: SHF specification
has exact synonym: second heart field specification
has related synonym: anterior heart field specification
type: Class
subclass of: heart field specification

determination of left/right asymmetry in lateral mesoderm
IAO_0000115: The establishment of the lateral mesoderm with respect to the left and right halves.
type: Class
subclass of: part-of-parent-48368
subclass of: GO_0007368

obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
IAO_0000115: OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination.
type: Class
subclass of: ObsoleteClass

cardiogenic plate morphogenesis
IAO_0000115: The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.
has exact synonym: cardiac crescent morphogenesis
type: Class
subclass of: part-of-parent-3007
subclass of: GO_0009653

embryonic heart tube morphogenesis
IAO_0000115: The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
type: Class
subclass of: part-of-parent-3007
subclass of: part-of-parent-35050
subclass of: part-of-parent-48562
subclass of: GO_0048598
subclass of: GO_0060562

embryonic heart tube formation
IAO_0000115: The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
type: Class
subclass of: embryonic epithelial tube formation
subclass of: part-of-parent-3143

embryonic heart tube formation via epithelial folding
IAO_0000115: The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.
type: Class
subclass of: embryonic heart tube formation

heart jogging
IAO_0000115: The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.
has exact synonym: cardiac jogging
type: Class
subclass of: embryonic heart tube morphogenesis
subclass of: part-of-parent-61371

neural crest cell migration involved in heart formation
IAO_0000115: The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.
type: Class
subclass of: neural crest cell migration
subclass of: part-of-parent-60914
subclass of: part-of-parent-61308
subclass of: GO_0060974

outflow tract septum morphogenesis
IAO_0000115: The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
type: Class
subclass of: part-of-parent-3151
subclass of: GO_0060411

membranous septum morphogenesis
IAO_0000115: The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
type: Class
subclass of: part-of-parent-60412
subclass of: GO_0009653

muscular septum morphogenesis
IAO_0000115: The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
type: Class
subclass of: part-of-parent-60412
subclass of: GO_0060415

outflow tract morphogenesis
IAO_0000115: The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
type: Class
subclass of: part-of-parent-3007
subclass of: GO_0009653

morphogenesis of an epithelial fold involved in embryonic heart tube formation
IAO_0000115: The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.
type: Class
subclass of: part-of-parent-3144
subclass of: part-of-parent-3145
subclass of: GO_0048598
subclass of: GO_0060571

closure of embryonic heart tube
IAO_0000115: Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.
type: Class
subclass of: part-of-parent-3145
subclass of: GO_0060606

BMP signaling pathway involved in determination of left/right symmetry
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
has exact synonym: BMP signaling pathway involved in determination of left/right asymmetry
has exact synonym: BMP signalling pathway involved in determination of left/right symmetry
type: Class
subclass of: part-of-parent-7368
subclass of: GO_0030509

BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
IAO_0000115: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry.
has exact synonym: BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination
has exact synonym: BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry
type: Class
subclass of: BMP signaling pathway involved in determination of left/right symmetry
subclass of: part-of-parent-3140

regulation of animal organ formation
IAO_0000115: Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
type: Class
subclass of: GO_2000027

endocardium development
IAO_0000115: The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0048856

endothelium development
IAO_0000115: The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
type: Class
subclass of: GO_0060429

morphogenesis of an endothelium
IAO_0000115: The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
type: Class
subclass of: morphogenesis of an epithelium
subclass of: part-of-parent-3158

endocardium morphogenesis
IAO_0000115: The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
type: Class
subclass of: part-of-parent-3157
subclass of: GO_0009653

cardiac conduction system development
IAO_0000115: The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
has exact synonym: cardiac impulse conducting system development
has exact synonym: heart conduction system development
type: Class
subclass of: GO_0048738

atrioventricular node development
IAO_0000115: The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.
has exact synonym: AV node development
type: Class
subclass of: part-of-parent-3161
subclass of: GO_0048738

sinoatrial node development
IAO_0000115: The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.
has exact synonym: SA node development
has exact synonym: SAN development
has related synonym: sinus node development
type: Class
subclass of: part-of-parent-3161
subclass of: GO_0048738

His-Purkinje system development
IAO_0000115: The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.
type: Class
subclass of: part-of-parent-3161
subclass of: ventricular cardiac muscle tissue development

Purkinje myocyte development
IAO_0000115: The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.
has exact synonym: cardiac Purkinje fiber development
type: Class
subclass of: part-of-parent-3164
subclass of: ventricular cardiac muscle tissue development

bundle of His development
IAO_0000115: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.
has exact synonym: atrioventricular bundle development
type: Class
subclass of: part-of-parent-3164
subclass of: ventricular cardiac muscle tissue development

atrioventricular bundle cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.
has exact synonym: AV bundle cell differentiation
type: Class
subclass of: part-of-parent-3166
subclass of: GO_0060932

Purkinje myocyte differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.
has exact synonym: cardiac Purkinje fiber cell differentiation
type: Class
subclass of: part-of-parent-3165
subclass of: GO_0060932

coronary vein morphogenesis
IAO_0000115: The process in which the anatomical structures of veins of the heart are generated and organized.
type: Class
subclass of: GO_0048845
subclass of: GO_0060977

heart valve development
IAO_0000115: The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.
has exact synonym: cardiac valve development
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0048856

atrioventricular valve development
IAO_0000115: The progression of the atrioventricular valve over time, from its formation to the mature structure.
has exact synonym: AV valve development
type: Class
subclass of: heart valve development

sinoatrial valve development
IAO_0000115: The progression of the sinoatrial valve over time, from its formation to the mature structure.
has exact synonym: SA valve development
type: Class
subclass of: heart valve development

ventriculo bulbo valve development
IAO_0000115: The progression of the ventriculo bulbo valve over time, from its formation to the mature structure.
type: Class
subclass of: heart valve development

mitral valve development
IAO_0000115: The progression of the mitral valve over time, from its formation to the mature structure.
type: Class
subclass of: atrioventricular valve development

tricuspid valve development
IAO_0000115: The progression of the tricuspid valve over time, from its formation to the mature structure.
type: Class
subclass of: atrioventricular valve development

aortic valve development
IAO_0000115: The progression of the aortic valve over time, from its formation to the mature structure.
type: Class
subclass of: GO_1905314

pulmonary valve development
IAO_0000115: The progression of the pulmonary valve over time, from its formation to the mature structure.
type: Class
subclass of: GO_1905314

coronary sinus valve development
IAO_0000115: The progression of the valve of the coronary sinus over time, from its formation to the mature structure.
type: Class
subclass of: heart valve development

heart valve morphogenesis
IAO_0000115: The process in which the structure of a heart valve is generated and organized.
has related synonym: heart valve remodeling
has related synonym: heart valve remodelling
type: Class
subclass of: part-of-parent-3170
subclass of: GO_0009653

aortic valve morphogenesis
IAO_0000115: The process in which the structure of the aortic valve is generated and organized.
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3176

atrioventricular valve morphogenesis
IAO_0000115: The process in which the structure of the atrioventricular valve is generated and organized.
has exact synonym: AV valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3171

coronary sinus valve morphogenesis
IAO_0000115: The process in which the structure of the coronary sinus valve is generated and organized.
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3178

mitral valve morphogenesis
IAO_0000115: The process in which the structure of the mitral valve is generated and organized.
type: Class
subclass of: atrioventricular valve morphogenesis
subclass of: part-of-parent-3174

pulmonary valve morphogenesis
IAO_0000115: The process in which the structure of the pulmonary valve is generated and organized.
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3177

sinoatrial valve morphogenesis
IAO_0000115: The process in which the structure of the sinoatrial valve is generated and organized.
has exact synonym: SA valve morphogenesis
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3172

tricuspid valve morphogenesis
IAO_0000115: The process in which the structure of the tricuspid valve is generated and organized.
type: Class
subclass of: atrioventricular valve morphogenesis
subclass of: part-of-parent-3175

ventriculo bulbo valve morphogenesis
IAO_0000115: The process in which the structure of the ventriculo bulbo valve is generated and organized.
type: Class
subclass of: heart valve morphogenesis
subclass of: part-of-parent-3173

heart valve formation
IAO_0000115: The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: part-of-parent-3179
subclass of: GO_0048646

aortic valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3180

atrioventricular valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has exact synonym: AV valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3181

coronary sinus valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3182

mitral valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: atrioventricular valve formation
subclass of: part-of-parent-3183

pulmonary valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3184

sinoatrial valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
has exact synonym: SA valve formation
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3185

tricuspid valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: atrioventricular valve formation
subclass of: part-of-parent-3186

ventriculo bulbo valve formation
IAO_0000115: The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
type: Class
subclass of: heart valve formation
subclass of: part-of-parent-3187

endocardial cushion development
IAO_0000115: The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0060485

epithelial to mesenchymal transition involved in endocardial cushion formation
IAO_0000115: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.
type: Class
subclass of: part-of-parent-3272
subclass of: GO_0060317

endocardial cushion to mesenchymal transition involved in heart valve formation
IAO_0000115: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
has exact synonym: endocardial cushion to mesenchymal transition involved in valve formation
type: Class
subclass of: part-of-parent-3188
subclass of: GO_0090500

endocardial cushion to mesenchymal transition involved in heart chamber septation
IAO_0000115: A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum.
type: Class
subclass of: part-of-parent-60411
subclass of: GO_0090500

epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
IAO_0000115: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature.
type: Class
subclass of: part-of-parent-60977
subclass of: GO_0060317

endocardial cushion to mesenchymal transition involved in cardiac skeleton development
IAO_0000115: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton.
type: Class
subclass of: part-of-parent-3204
subclass of: GO_0090500

endocardial cushion morphogenesis
IAO_0000115: The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
type: Class
subclass of: part-of-parent-3007
subclass of: part-of-parent-3197
subclass of: GO_0072132

cardiac skeleton development
IAO_0000115: The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.
has exact synonym: heart fibrous skeleton development
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0061448

cardiac chamber development
IAO_0000115: The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0048856

cardiac chamber morphogenesis
IAO_0000115: The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
has exact synonym: heart chamber morphogenesis
type: Class
subclass of: part-of-parent-3007
subclass of: part-of-parent-3205
subclass of: GO_0009653

cardiac chamber formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
has exact synonym: heart chamber formation
type: Class
subclass of: part-of-parent-3206
subclass of: GO_0048646

cardiac ventricle morphogenesis
IAO_0000115: The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3231

cardiac atrium morphogenesis
IAO_0000115: The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3230

cardiac atrium formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3209

cardiac ventricle formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3208

cardiac left atrium morphogenesis
IAO_0000115: The process in which the left cardiac atrium is generated and organized.
type: Class
subclass of: cardiac atrium morphogenesis

cardiac right atrium morphogenesis
IAO_0000115: The process in which the right cardiac atrium is generated and organized.
type: Class
subclass of: cardiac atrium morphogenesis

cardiac left ventricle morphogenesis
IAO_0000115: The process in which the left cardiac ventricle is generated and organized.
type: Class
subclass of: cardiac ventricle morphogenesis

cardiac right ventricle morphogenesis
IAO_0000115: The process in which the right cardiac ventricle is generated and organized.
type: Class
subclass of: cardiac ventricle morphogenesis

cardiac left atrium formation
IAO_0000115: The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.
type: Class
subclass of: cardiac atrium formation
subclass of: part-of-parent-3212

cardiac right atrium formation
IAO_0000115: The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.
type: Class
subclass of: cardiac atrium formation
subclass of: part-of-parent-3213

cardiac left ventricle formation
IAO_0000115: The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.
type: Class
subclass of: cardiac ventricle formation
subclass of: part-of-parent-3214

cardiac right ventricle formation
IAO_0000115: The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.
type: Class
subclass of: cardiac ventricle formation
subclass of: part-of-parent-3215

left ventricular cardiac muscle tissue morphogenesis
IAO_0000115: The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.
has exact synonym: left ventricular myocardium morphogenesis
type: Class
subclass of: part-of-parent-3214
subclass of: GO_0055010

right ventricular cardiac muscle tissue morphogenesis
IAO_0000115: The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.
has exact synonym: right ventricle myocardium morphogenesis
type: Class
subclass of: part-of-parent-3215
subclass of: GO_0055010

ventricular trabecula myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
has related synonym: trabecula carnea morphogenesis
type: Class
subclass of: GO_0055010
subclass of: GO_0061384

ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.
type: Class
subclass of: GO_0055010

left ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized.
type: Class
subclass of: left ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular compact myocardium morphogenesis

left ventricular trabecular myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.
type: Class
subclass of: left ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular trabecula myocardium morphogenesis

right ventricular compact myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized.
type: Class
subclass of: right ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular compact myocardium morphogenesis

right ventricular trabecular myocardium morphogenesis
IAO_0000115: The process in which the anatomical structures of the right ventricular myocardium are generated and organized.
type: Class
subclass of: right ventricular cardiac muscle tissue morphogenesis
subclass of: ventricular trabecula myocardium morphogenesis

atrial cardiac muscle tissue development
IAO_0000115: The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.
has exact synonym: atrial myocardium development
type: Class
subclass of: GO_0048856

ventricular cardiac muscle tissue development
IAO_0000115: The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
has exact synonym: ventricular myocardium development
type: Class
subclass of: GO_0048738

cardiac atrium development
IAO_0000115: The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
type: Class
subclass of: cardiac chamber development

cardiac ventricle development
IAO_0000115: The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
type: Class
subclass of: cardiac chamber development

bulbus arteriosus development
IAO_0000115: The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber.
type: Class
subclass of: cardiac chamber development

bulbus arteriosus morphogenesis
IAO_0000115: The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber.
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3232

bulbus arteriosus formation
IAO_0000115: The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart.
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3233

sinus venosus development
IAO_0000115: The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
type: Class
subclass of: cardiac chamber development

sinus venosus morphogenesis
IAO_0000115: The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3235

sinus venosus formation
IAO_0000115: The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3236

conus arteriosus development
IAO_0000115: The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
type: Class
subclass of: cardiac chamber development

conus arteriosus morphogenesis
IAO_0000115: The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
type: Class
subclass of: cardiac chamber morphogenesis
subclass of: part-of-parent-3238

conus arteriosus formation
IAO_0000115: The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
type: Class
subclass of: cardiac chamber formation
subclass of: part-of-parent-3239

growth involved in heart morphogenesis
IAO_0000115: Developmental growth that contributes to the shaping of the heart.
type: Class
subclass of: part-of-parent-3007
subclass of: part-of-parent-60419
subclass of: GO_0060560

cardiac chamber ballooning
IAO_0000115: The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping.
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3206

circumferential growth involved in left ventricle morphogenesis
IAO_0000115: The morphogenetic growth in which the left ventricle grows expanding its external boundary.
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3214

radial growth involved in right ventricle morphogenesis
IAO_0000115: The morphogenic growth in which the right ventricle grows along a radial axis.
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3215

cardiac muscle tissue growth involved in heart morphogenesis
IAO_0000115: The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3007
subclass of: part-of-parent-55008
subclass of: GO_0055017

embryonic cardiac muscle cell growth involved in heart morphogenesis
IAO_0000115: The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart.
has exact synonym: embryonic cardiac muscle physiological hypertrophy
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3245
subclass of: GO_0061049

post-embryonic cardiac muscle cell growth involved in heart morphogenesis
IAO_0000115: The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.
type: Class
subclass of: growth involved in heart morphogenesis
subclass of: part-of-parent-3245
subclass of: GO_0048588

heart capillary growth
IAO_0000115: The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.
type: Class
subclass of: part-of-parent-60419
subclass of: part-of-parent-60976
subclass of: GO_0048589

cell proliferation involved in heart valve morphogenesis
IAO_0000115: The multiplication or reproduction of cells that contributes to the shaping of a heart valve.
type: Class
subclass of: part-of-parent-3179
subclass of: GO_0061323
subclass of: GO_2000793

regulation of cell proliferation involved in heart valve morphogenesis
IAO_0000115: Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
type: Class
subclass of: GO_2000136

positive regulation of cell proliferation involved in heart valve morphogenesis
IAO_0000115: Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
type: Class
subclass of: regulation of cell proliferation involved in heart valve morphogenesis
subclass of: GO_2000138

negative regulation of cell proliferation involved in heart valve morphogenesis
IAO_0000115: Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
type: Class
subclass of: regulation of cell proliferation involved in heart valve morphogenesis
subclass of: GO_2000137

cardiac neural crest cell migration involved in outflow tract morphogenesis
IAO_0000115: The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.
type: Class
subclass of: neural crest cell migration
subclass of: part-of-parent-3151
subclass of: part-of-parent-61309
subclass of: GO_0060973

regulation of membrane depolarization
IAO_0000115: Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
type: Class
subclass of: GO_0042391
subclass of: GO_0050794
subclass of: GO_0050801

endocardial precursor cell differentiation
IAO_0000115: The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate.
type: Class
subclass of: GO_0010002

regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
IAO_0000115: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.
type: Class
subclass of: part-of-parent-60379
subclass of: GO_1901213

positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
IAO_0000115: Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.
type: Class
subclass of: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
subclass of: part-of-parent-60379
subclass of: GO_1901228

regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
IAO_0000115: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell.
type: Class
subclass of: part-of-parent-3255
subclass of: GO_1901213

cardioblast anterior-lateral migration
IAO_0000115: The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
type: Class
subclass of: cardioblast migration

cardioblast migration
IAO_0000115: The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
type: Class
subclass of: GO_0060974

cardiac muscle progenitor cell migration to the midline involved in heart field formation
IAO_0000115: The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart.
has exact synonym: myocardial progenitor cell midline convergence
type: Class
subclass of: GO_0060975

endocardial progenitor cell migration to the midline involved in heart field formation
IAO_0000115: The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.
type: Class
subclass of: GO_0060975

cardioblast proliferation
IAO_0000115: The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
type: Class
subclass of: part-of-parent-60914
subclass of: GO_0061323

regulation of cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
type: Class
subclass of: regulation of animal organ formation
subclass of: GO_2000136

regulation of primary heart field cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle.
has exact synonym: regulation of FHF cardioblast proliferation
has exact synonym: regulation of first heart field cardioblast proliferation
has related synonym: regulation of first heart field cardiac proliferation
type: Class
subclass of: regulation of cardioblast proliferation

regulation of secondary heart field cardioblast proliferation
IAO_0000115: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).
has exact synonym: regulation of SHF cardioblast proliferation
has exact synonym: regulation of second heart field cardioblast proliferation
type: Class
subclass of: regulation of cardioblast proliferation

canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
IAO_0000115: A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation
has exact synonym: canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
has exact synonym: canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation
has related synonym: canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: part-of-parent-72513
subclass of: GO_0044340
subclass of: GO_0061316

fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation
has exact synonym: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation
has exact synonym: fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation
type: Class
subclass of: part-of-parent-3266
subclass of: GO_0061313

BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: BMP signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: part-of-parent-3266
subclass of: GO_0061312

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation
has related synonym: Notch signaling pathway involved in regulation of second heart field cardioblast proliferation
type: Class
subclass of: part-of-parent-3266
subclass of: GO_0061314

smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
IAO_0000115: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
has exact synonym: hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: hh signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation
has exact synonym: smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
has exact synonym: smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation
type: Class
subclass of: part-of-parent-3266
subclass of: GO_0007224
subclass of: GO_0061311

endocardial cushion formation
IAO_0000115: The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
type: Class
subclass of: part-of-parent-3203
subclass of: GO_0048646

cell migration involved in endocardial cushion formation
IAO_0000115: The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
type: Class
subclass of: part-of-parent-3272
subclass of: GO_0060973

endocardial cushion fusion
IAO_0000115: The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.
type: Class
subclass of: part-of-parent-3203
subclass of: GO_0061343
subclass of: GO_0098742

apoptotic process involved in outflow tract morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.
has related synonym: apoptosis involved in outflow tract morphogenesis
type: Class
subclass of: part-of-parent-3151
subclass of: apoptotic process involved in heart morphogenesis

apoptotic process involved in heart valve morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of a heart valve.
has related synonym: apoptosis involved in heart valve morphogenesis
type: Class
subclass of: part-of-parent-3179
subclass of: apoptotic process involved in heart morphogenesis

apoptotic process involved in endocardial cushion morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
has related synonym: apoptosis involved in endocardial cushion morphogenesis
type: Class
subclass of: part-of-parent-3203
subclass of: apoptotic process involved in heart morphogenesis

apoptotic process involved in heart morphogenesis
IAO_0000115: Any apoptotic process that contributes to the shaping of the heart.
has related synonym: apoptosis involved in heart morphogenesis
type: Class
subclass of: part-of-parent-3007
subclass of: GO_0060561

cardiac septum development
IAO_0000115: The progression of a cardiac septum over time, from its initial formation to the mature structure.
has exact synonym: heart septum development
type: Class
subclass of: part-of-parent-3205
subclass of: GO_0048856

ventricular septum development
IAO_0000115: The progression of the ventricular septum over time from its formation to the mature structure.
has exact synonym: interventricular septum development
has related synonym: septum inferius development
type: Class
subclass of: cardiac septum development
subclass of: part-of-parent-3231

ventricular septum intermedium development
IAO_0000115: The progression of the ventricular septum intermedium over time, from its formation to the mature structure.
type: Class
subclass of: ventricular septum development

atrial septum development
IAO_0000115: The progression of the atrial septum over time, from its initial formation to the mature structure.
type: Class
subclass of: cardiac septum development
subclass of: part-of-parent-3230

septum primum development
IAO_0000115: The progression of the septum primum over time, from its formation to the mature structure.
type: Class
subclass of: atrial septum development

septum secundum development
IAO_0000115: The progression of the septum secundum over time, from its initial formation to the mature structure.
type: Class
subclass of: atrial septum development

atrial septum intermedium development
IAO_0000115: The progression of the atrial septum intermedium over time, from its formation to the mature structure.
type: Class
subclass of: atrial septum development

ventricular septum intermedium morphogenesis
IAO_0000115: The developmental process in which a ventricular septum intermedium is generated and organized.
type: Class
subclass of: GO_0060412

atrial septum primum morphogenesis
IAO_0000115: The process in which anatomical structure of an atrial septum primum is generated and organized.
type: Class
subclass of: part-of-parent-3284
subclass of: GO_0060413

atrial septum secundum morphogenesis
IAO_0000115: The process in which anatomical structure of an atrial septum secundum is generated and organized.
type: Class
subclass of: part-of-parent-3285
subclass of: GO_0060413

atrial septum intermedium morphogenesis
IAO_0000115: The process in which anatomical structure of an atrial septum intermedium is generated and organized.
type: Class
subclass of: part-of-parent-3286
subclass of: GO_0060413

cardiac septum cell differentiation
IAO_0000115: The process in which an endocardial cushion cell becomes a cell of a cardiac septum.
type: Class
subclass of: part-of-parent-3279
subclass of: GO_0035051

heart valve cell differentiation
IAO_0000115: The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.
type: Class
subclass of: part-of-parent-3170
subclass of: GO_0035051

atrial ventricular junction remodeling
IAO_0000115: The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.
has exact synonym: atrioventricular junction remodeling
has related synonym: atrio-ventricular junction remodeling
type: Class
subclass of: part-of-parent-3007
subclass of: GO_0048771

cell proliferation involved in atrial ventricular junction remodeling
IAO_0000115: The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
has exact synonym: cell proliferation involved in atrio-ventricular junction remodeling
has exact synonym: cell proliferation involved in atrioventricular junction remodeling
type: Class
subclass of: part-of-parent-3294
subclass of: GO_0061323

apoptotic process involved in atrial ventricular junction remodeling
IAO_0000115: Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.
has exact synonym: apoptosis involved in atrio-ventricular junction remodeling
has exact synonym: apoptosis involved in atrioventricular junction remodeling
has related synonym: apoptosis involved in atrial ventricular junction remodeling
type: Class
subclass of: apoptotic process involved in heart morphogenesis
subclass of: part-of-parent-3294

heart wedging
IAO_0000115: The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart.
type: Class
subclass of: part-of-parent-3007
subclass of: GO_0009653

physiological muscle hypertrophy
IAO_0000115: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.
type: Class
subclass of: GO_0014896

muscle hypertrophy in response to stress
IAO_0000115: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.
type: Class
subclass of: GO_0006950
subclass of: GO_0014896
subclass of: GO_0043500

cardiac muscle hypertrophy
IAO_0000115: The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
type: Class
subclass of: GO_0014897

physiological cardiac muscle hypertrophy
IAO_0000115: The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.
type: Class
subclass of: physiological muscle hypertrophy
subclass of: cardiac muscle hypertrophy
subclass of: part-of-parent-55017

transforming growth factor beta receptor signaling pathway involved in heart jogging
IAO_0000115: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.
has exact synonym: transforming growth factor beta receptor signalling pathway involved in heart jogging
type: Class
subclass of: part-of-parent-3146
subclass of: GO_0035463
subclass of: GO_1905313

BMP signaling pathway involved in heart jogging
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.
has exact synonym: BMP signalling pathway involved in heart jogging
type: Class
subclass of: BMP signaling pathway involved in determination of left/right symmetry
subclass of: part-of-parent-3146
subclass of: GO_0061312

myocardial epithelial involution involved in heart jogging
IAO_0000115: The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging.
type: Class
subclass of: part-of-parent-3146
subclass of: GO_0060571

cell migration involved in heart jogging
IAO_0000115: The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging.
type: Class
subclass of: part-of-parent-3146
subclass of: GO_0060973

Wnt signaling pathway involved in heart development
IAO_0000115: The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: Wnt receptor signaling pathway involved in heart development
has exact synonym: Wnt receptor signalling pathway involved in heart development
has exact synonym: Wnt-activated signaling pathway involved in heart development
type: Class
subclass of: part-of-parent-7507
subclass of: GO_0016055
subclass of: GO_0061311

regulation of Wnt signaling pathway involved in heart development
IAO_0000115: Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: regulation of Wnt receptor signaling pathway involved in heart development
has exact synonym: regulation of Wnt receptor signalling pathway involved in heart development
has exact synonym: regulation of Wnt-activated signaling pathway involved in heart development
type: Class
subclass of: GO_0030111
subclass of: GO_2000026

negative regulation of Wnt signaling pathway involved in heart development
IAO_0000115: Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
has exact synonym: negative regulation of Wnt receptor signaling pathway involved in heart development
has exact synonym: negative regulation of Wnt receptor signalling pathway involved in heart development
has exact synonym: negative regulation of Wnt-activated signaling pathway involved in heart development
type: Class
subclass of: regulation of Wnt signaling pathway involved in heart development
subclass of: GO_0030178
subclass of: GO_0051093
subclass of: GO_0051241

type B pancreatic cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell differentiation
has exact synonym: pancreatic beta cell differentiation
type: Class
subclass of: part-of-parent-31018
subclass of: GO_0035883

pancreatic A cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has exact synonym: pancreatic alpha cell differentiation
type: Class
subclass of: part-of-parent-31018
subclass of: GO_0035883

pancreatic D cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.
has exact synonym: pancreatic delta cell differentiation
type: Class
subclass of: part-of-parent-31018
subclass of: GO_0035883

pancreatic PP cell differentiation
IAO_0000115: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
has exact synonym: pancreatic polypeptide-producing cell differentiation
type: Class
subclass of: part-of-parent-31018
subclass of: GO_0035883

heart rudiment development
IAO_0000115: The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
has exact synonym: heart cone development
type: Class
subclass of: part-of-parent-35050
subclass of: GO_0060429

heart rudiment morphogenesis
IAO_0000115: The process in which the anatomical structures of the heart rudiment are generated and organized.
has exact synonym: heart cone morphogenesis
type: Class
subclass of: morphogenesis of an epithelium
subclass of: part-of-parent-3313
subclass of: GO_0048598

heart rudiment formation
IAO_0000115: The developmental process pertaining to the initial formation of the heart rudiment.
has exact synonym: heart cone formation
type: Class
subclass of: part-of-parent-3314
subclass of: GO_0048646

establishment of myocardial progenitor cell apical/basal polarity
IAO_0000115: The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment.
has exact synonym: myocardial progenitor epithelial polarization
type: Class
subclass of: part-of-parent-3315
subclass of: GO_0045198

cardioblast cell midline fusion
IAO_0000115: The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment.
has exact synonym: cardiac progenitor cell midline fusion
type: Class
subclass of: part-of-parent-3315
subclass of: GO_0034109

cell migration to the midline involved in heart development
IAO_0000115: The orderly movement of a cell toward the midline that contributes to the progression of the heart over time.
type: Class
subclass of: GO_0060973

cardioblast migration to the midline involved in heart rudiment formation
IAO_0000115: The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.
type: Class
subclass of: cell migration to the midline involved in heart development
subclass of: part-of-parent-3315

heart rudiment involution
IAO_0000115: The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube.
type: Class
subclass of: morphogenesis of an epithelial fold involved in embryonic heart tube formation

positive regulation of blood pressure by epinephrine-norepinephrine
IAO_0000115: Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine.
type: Class
subclass of: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
subclass of: GO_0045777

pancreatic A cell development
IAO_0000115: The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
has exact synonym: pancreatic alpha cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3310

type B pancreatic cell development
IAO_0000115: The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell development
has exact synonym: pancreatic beta cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3309

pancreatic D cell development
IAO_0000115: The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.
has exact synonym: pancreatic delta cell development
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3311

pancreatic PP cell development
IAO_0000115: The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
type: Class
subclass of: glandular epithelial cell development
subclass of: part-of-parent-3312

pancreatic A cell fate commitment
IAO_0000115: The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
type: Class
subclass of: part-of-parent-3310
subclass of: GO_0072148

type B pancreatic cell fate commitment
IAO_0000115: The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
has exact synonym: pancreatic B cell fate commitment
type: Class
subclass of: part-of-parent-3309
subclass of: GO_0072148

pancreatic D cell fate commitment
IAO_0000115: The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin.
type: Class
subclass of: part-of-parent-3311
subclass of: GO_0072148

pancreatic PP cell fate commitment
IAO_0000115: The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
type: Class
subclass of: part-of-parent-3312
subclass of: GO_0072148

regulation of extracellular matrix constituent secretion
IAO_0000115: Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
type: Class
subclass of: GO_1903053
subclass of: GO_1903530

positive regulation of extracellular matrix constituent secretion
IAO_0000115: Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
type: Class
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_1903055
subclass of: GO_1903532

negative regulation of extracellular matrix constituent secretion
IAO_0000115: Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
type: Class
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_1903054
subclass of: GO_1903531

amino acid transmembrane transport
IAO_0000115: The process in which an amino acid is transported across a membrane.
has exact synonym: amino acid membrane transport
type: Class
subclass of: GO_0006865
subclass of: GO_1905039

keratinocyte development
IAO_0000115: The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.
type: Class
subclass of: epithelial cell development
subclass of: part-of-parent-30216

corneocyte development
IAO_0000115: The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.
type: Class
subclass of: part-of-parent-3334
subclass of: GO_0048468

corneocyte desquamation
IAO_0000115: The delamination process that results in the shedding of a corneocyte from the surface of the epidermis.
has exact synonym: epidermal desquamation
type: Class
subclass of: part-of-parent-3335
subclass of: GO_0060232

mesenchymal to epithelial transition involved in metanephros morphogenesis
IAO_0000115: A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
has related synonym: metanephric mesenchyme to epithelial transition
type: Class
subclass of: part-of-parent-3338
subclass of: part-of-parent-72283
subclass of: GO_0035850
subclass of: GO_0060231
subclass of: GO_0072202

metanephros morphogenesis
IAO_0000115: The process in which the anatomical structures of the metanephros are generated and organized.
type: Class
subclass of: part-of-parent-1656
subclass of: GO_0060993

regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
IAO_0000115: Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
type: Class
subclass of: GO_0072215
subclass of: GO_1905330
subclass of: GO_2000027
subclass of: GO_2000696

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
IAO_0000115: Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
type: Class
subclass of: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
subclass of: GO_0072217
subclass of: GO_0110111
subclass of: GO_1905331
subclass of: GO_2000697

cilium movement
IAO_0000115: The directed, self-propelled movement of a cilium.
has exact synonym: microtubule-based flagellum movement
has related synonym: ciliary motility
has related synonym: cilium beating
has related synonym: flagellar motility
has related synonym: flagellar movement
has related synonym: flagellum movement
replaces: GO_0036142
type: Class
subclass of: GO_0007018

proepicardium development
IAO_0000115: The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.
type: Class
subclass of: part-of-parent-3343
subclass of: GO_0060485

septum transversum development
IAO_0000115: The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.
type: Class
subclass of: GO_0060485

pericardium morphogenesis
IAO_0000115: The process in which the anatomical structure of the pericardium is generated and organized.
type: Class
subclass of: morphogenesis of an epithelial sheet
subclass of: part-of-parent-60039
subclass of: GO_0048598

proepicardium cell migration involved in pericardium morphogenesis
IAO_0000115: The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart.
type: Class
subclass of: part-of-parent-3344
subclass of: GO_0060973

epicardium-derived cell migration to the myocardium
IAO_0000115: The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium.
type: Class
subclass of: GO_0060973

epicardial cell to mesenchymal cell transition
IAO_0000115: A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.
type: Class
subclass of: epithelial to mesenchymal transition

cardiac endothelial cell differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.
type: Class
subclass of: GO_0035051
subclass of: GO_0045446

epicardium-derived cardiac endothelial cell differentiation
IAO_0000115: The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.
type: Class
subclass of: cardiac endothelial cell differentiation

pulmonary myocardium development
IAO_0000115: The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.
type: Class
subclass of: part-of-parent-60841
subclass of: GO_0014706

epithelial cilium movement involved in extracellular fluid movement
IAO_0000115: The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
has related synonym: cilium movement involved in fluid flow
has related synonym: epithelial cilium beating
type: Class
subclass of: cilium movement
subclass of: GO_0006858
subclass of: GO_0099111

regulation of cilium movement
IAO_0000115: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has exact synonym: regulation of microtubule-based flagellum movement
has related synonym: regulation of flagellar movement
has related synonym: regulation of flagellum movement
replaces: GO_1900172
type: Class
subclass of: GO_0060632

positive regulation of cilium movement
IAO_0000115: Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has exact synonym: positive regulation of microtubule-based flagellum movement
has related synonym: positive regulation of flagellar movement
has related synonym: positive regulation of flagellum movement
replaces: GO_1900174
type: Class
subclass of: regulation of cilium movement
subclass of: GO_0051272

negative regulation of cilium movement
IAO_0000115: Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
has exact synonym: negative regulation of microtubule-based flagellum movement
has related synonym: negative regulation of flagellum movement
replaces: GO_1900173
type: Class
subclass of: regulation of cilium movement
subclass of: GO_0051271

cilium movement involved in otolith formation
IAO_0000115: The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles.
type: Class
subclass of: epithelial cilium movement involved in extracellular fluid movement
subclass of: part-of-parent-32475

regulation of cilium beat frequency
IAO_0000115: Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.
has exact synonym: regulation of microtubule-based flagellum beat frequency
has related synonym: regulation of flagellum beat frequency
replaces: GO_0036144
type: Class
subclass of: regulation of cilium movement

noradrenergic neuron differentiation
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.
has exact synonym: norepinephrine secreting neuron differentiation
type: Class
subclass of: GO_0030182

noradrenergic neuron development
IAO_0000115: The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has exact synonym: norepinephrine secreting neuron development
type: Class
subclass of: part-of-parent-3357
subclass of: GO_0048666

noradrenergic neuron fate commitment
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron.
has exact synonym: norepinephrine secreting neuron fate commitment
type: Class
subclass of: part-of-parent-3357
subclass of: GO_0048663

brainstem development
IAO_0000115: The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.
type: Class
subclass of: GO_0048856

noradrenergic neuron differentiation involved in brainstem development
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem.
type: Class
subclass of: noradrenergic neuron differentiation
subclass of: part-of-parent-3360

noradrenergic neuron fate commitment involved in brainstem development
IAO_0000115: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem.
type: Class
subclass of: noradrenergic neuron fate commitment
subclass of: part-of-parent-3360
subclass of: part-of-parent-3361

lamellipodium assembly involved in ameboidal cell migration
IAO_0000115: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.
type: Class
subclass of: part-of-parent-1667
subclass of: GO_0030032

lamellipodium assembly involved in mesendodermal cell migration
IAO_0000115: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell.
type: Class
subclass of: lamellipodium assembly involved in ameboidal cell migration
subclass of: part-of-parent-90134
subclass of: GO_0010927

establishment of cell polarity involved in ameboidal cell migration
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.
type: Class
subclass of: part-of-parent-1667
subclass of: GO_0030010

cell-matrix adhesion involved in ameboidal cell migration
IAO_0000115: The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.
type: Class
subclass of: part-of-parent-1667
subclass of: GO_0007160

cell-cell adhesion involved in ameboidal cell migration
IAO_0000115: The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells.
type: Class
subclass of: part-of-parent-3365
subclass of: GO_0098742

cell-matrix adhesion involved in mesendodermal cell migration
IAO_0000115: The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell.
type: Class
subclass of: cell-matrix adhesion involved in ameboidal cell migration
subclass of: part-of-parent-90134

establishment of cell polarity involved in mesendodermal cell migration
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell.
type: Class
subclass of: part-of-parent-90134
subclass of: establishment of cell polarity involved in gastrulation cell migration

cell-cell adhesion involved in mesendodermal cell migration
IAO_0000115: The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm.
type: Class
subclass of: cell-cell adhesion involved in ameboidal cell migration
subclass of: part-of-parent-3369
subclass of: GO_0070586

establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.
type: Class
subclass of: part-of-parent-1667
subclass of: part-of-parent-3365
subclass of: GO_0030952

establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell.
type: Class
subclass of: part-of-parent-3369
subclass of: part-of-parent-90134
subclass of: establishment or maintenance of cytoskeleton polarity involved in gastrulation

dynamin family protein polymerization involved in membrane fission
IAO_0000115: The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission.
type: Class
subclass of: part-of-parent-90148
subclass of: GO_0051258

dynamin family protein polymerization involved in mitochondrial fission
IAO_0000115: The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission.
type: Class
subclass of: dynamin family protein polymerization involved in membrane fission

regulation of dynamin family protein polymerization involved in membrane fission
IAO_0000115: Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission.
type: Class
subclass of: GO_0032271

sphingosine-1-phosphate receptor signaling pathway
IAO_0000115: A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
has exact synonym: S1P receptor signaling pathway
has exact synonym: S1P-activated G-protein coupled receptor signaling pathway
has exact synonym: S1P-activated GPCR signaling pathway
has exact synonym: S1P-stimulated signal transduction pathway
has related synonym: S1P signaling pathway
has related synonym: sphingolipid signaling pathway
has related synonym: sphingolipid signalling pathway
replaces: GO_0001789
type: Class
subclass of: GO_0007186
subclass of: GO_0090520

obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway
IAO_0000115: OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis.
type: Class
subclass of: ObsoleteClass

obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
IAO_0000115: OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response.
type: Class
subclass of: ObsoleteClass

establishment of cell polarity involved in gastrulation cell migration
IAO_0000115: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.
type: Class
subclass of: establishment of cell polarity involved in ameboidal cell migration
subclass of: part-of-parent-42074

establishment or maintenance of cytoskeleton polarity involved in gastrulation
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.
type: Class
subclass of: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
subclass of: part-of-parent-3379
subclass of: part-of-parent-7369

epithelial cell morphogenesis involved in gastrulation
IAO_0000115: The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.
type: Class
subclass of: part-of-parent-7369
subclass of: epithelial cell morphogenesis

epithelial cell morphogenesis
IAO_0000115: The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: part-of-parent-2064

apical constriction
IAO_0000115: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.
type: Class
subclass of: part-of-parent-3382
subclass of: GO_0070252

apical constriction involved in gastrulation
IAO_0000115: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.
type: Class
subclass of: apical constriction
subclass of: part-of-parent-3381
subclass of: part-of-parent-7369

cell-cell signaling involved in amphid sensory organ development
IAO_0000115: Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state.
has exact synonym: cell-cell signalling involved in amphid sensory organ development
type: Class
subclass of: part-of-parent-3386
subclass of: GO_0007267

amphid sensory organ development
IAO_0000115: The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes.
type: Class
subclass of: GO_0007423

neuron differentiation involved in amphid sensory organ development
IAO_0000115: The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland.
type: Class
subclass of: part-of-parent-3386
subclass of: GO_0030182

neuron development involved in amphid sensory organ development
IAO_0000115: The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ.
type: Class
subclass of: part-of-parent-3386
subclass of: part-of-parent-3387
subclass of: GO_0048666

retrograde extension
IAO_0000115: The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.
type: Class
subclass of: GO_0031175

dendrite development by retrograde extension
IAO_0000115: The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point.
has exact synonym: dendrite retrograde extension
type: Class
subclass of: retrograde extension
subclass of: GO_0016358

amphid sensory organ dendrite retrograde extension
IAO_0000115: The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.
type: Class
subclass of: dendrite development by retrograde extension
subclass of: part-of-parent-3388

cell adhesion involved in retrograde extension
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension.
type: Class
subclass of: part-of-parent-3389
subclass of: GO_0007155

neuron migration involved in retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension.
type: Class
subclass of: neuron migration
subclass of: part-of-parent-3389

cell adhesion involved in dendrite retrograde extension
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite.
type: Class
subclass of: cell adhesion involved in retrograde extension
subclass of: part-of-parent-3390

neuron migration involved in dendrite retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite.
type: Class
subclass of: neuron migration involved in retrograde extension
subclass of: part-of-parent-3390

cell adhesion involved in amphid sensory organ dendrite retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ.
type: Class
subclass of: cell adhesion involved in dendrite retrograde extension
subclass of: part-of-parent-3391

neuron migration involved in amphid sensory organ dendrite retrograde extension
IAO_0000115: The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ.
type: Class
subclass of: neuron migration involved in dendrite retrograde extension
subclass of: part-of-parent-3391

glial cell differentiation involved in amphid sensory organ development
IAO_0000115: The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ.
type: Class
subclass of: part-of-parent-3386
subclass of: GO_0010001

cytoneme morphogenesis
IAO_0000115: The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell.
type: Class
subclass of: GO_0120039

regulation of COPII vesicle coating
IAO_0000115: Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
type: Class
subclass of: GO_0033043
subclass of: GO_0043254
subclass of: GO_0048209
subclass of: GO_0090113

axis elongation
IAO_0000115: The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.
has related synonym: elongation of an axis
type: Class
subclass of: GO_0060560

planar cell polarity pathway involved in axis elongation
IAO_0000115: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.
type: Class
subclass of: part-of-parent-3401
subclass of: GO_0060071

optic vesicle formation
IAO_0000115: The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
type: Class
subclass of: part-of-parent-3404
subclass of: part-of-parent-60900
subclass of: GO_0048646

optic vesicle morphogenesis
IAO_0000115: The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
type: Class
subclass of: part-of-parent-48596
subclass of: GO_0048598
subclass of: GO_0048729

optic vesicle elongation
IAO_0000115: The developmental growth that results in the lengthening of the optic vesicle in the posterior direction.
type: Class
subclass of: part-of-parent-3404
subclass of: GO_0060560

retinal pigment epithelium development
IAO_0000115: The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
has related synonym: RPE development
type: Class
subclass of: part-of-parent-60041
subclass of: GO_0060429

neural retina development
IAO_0000115: The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
type: Class
subclass of: part-of-parent-60041
subclass of: GO_0048856

optic cup formation involved in camera-type eye development
IAO_0000115: The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.
type: Class
subclass of: part-of-parent-2072
subclass of: GO_0048646

optic cup structural organization
IAO_0000115: The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure.
has exact synonym: optic cup structural organisation
type: Class
subclass of: part-of-parent-2072
subclass of: GO_0048532

anterior rotation of the optic cup
IAO_0000115: A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis.
type: Class
subclass of: part-of-parent-43010
subclass of: GO_0048856

cell motility involved in camera-type eye morphogenesis
IAO_0000115: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.
type: Class
subclass of: part-of-parent-48593
subclass of: GO_0048870

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
IAO_0000115: The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.
type: Class
subclass of: part-of-parent-48593
subclass of: GO_0045198

chondrocyte differentiation involved in endochondral bone morphogenesis
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
type: Class
subclass of: chondrocyte differentiation
subclass of: part-of-parent-60350
subclass of: part-of-parent-60351

chondrocyte morphogenesis involved in endochondral bone morphogenesis
IAO_0000115: The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.
type: Class
subclass of: part-of-parent-3433
subclass of: part-of-parent-60350
subclass of: GO_0090171

chondrocyte hypertrophy
IAO_0000115: The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time.
type: Class
subclass of: part-of-parent-2063
subclass of: GO_0048588

endochondral bone growth
IAO_0000115: The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.
type: Class
subclass of: GO_0098868

growth plate cartilage development
IAO_0000115: The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.
type: Class
subclass of: part-of-parent-3416
subclass of: GO_0060351
subclass of: GO_0061448

growth plate cartilage chondrocyte differentiation
IAO_0000115: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
type: Class
subclass of: chondrocyte differentiation involved in endochondral bone morphogenesis
subclass of: part-of-parent-3417

growth plate cartilage chondrocyte proliferation
IAO_0000115: The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
type: Class
subclass of: part-of-parent-3417
subclass of: GO_0008283

regulation of growth plate cartilage chondrocyte proliferation
IAO_0000115: Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
type: Class
subclass of: GO_0042127
subclass of: GO_0046620
subclass of: GO_0061035
subclass of: GO_1903010
subclass of: GO_2000027

growth plate cartilage axis specification
IAO_0000115: The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth.
has related synonym: growth plate cartilage axis determination
type: Class
subclass of: part-of-parent-3422
subclass of: GO_0009798

growth plate cartilage morphogenesis
IAO_0000115: The process in which the anatomical structures of growth plate cartilage are generated and organized.
type: Class
subclass of: part-of-parent-3417
subclass of: GO_0060536

growth plate cartilage chondrocyte division
IAO_0000115: The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate.
type: Class
subclass of: part-of-parent-3419
subclass of: GO_0051301

establishment of cell polarity involved in growth plate cartilage chondrocyte division
IAO_0000115: The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte.
has related synonym: growth plate cartilage chondrocyte polarization
type: Class
subclass of: establishment of planar polarity
subclass of: part-of-parent-3423
subclass of: GO_0030010

establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
IAO_0000115: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate.
type: Class
subclass of: establishment of mitotic spindle orientation
subclass of: part-of-parent-3423
subclass of: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
subclass of: GO_0090176

cytoskeleton polarization involved in growth plate cartilage chondrocyte division
IAO_0000115: A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.
type: Class
subclass of: part-of-parent-3424
subclass of: GO_0030952

regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
IAO_0000115: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.
has exact synonym: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway
type: Class
subclass of: regulation of growth plate cartilage chondrocyte proliferation
subclass of: GO_0051302
subclass of: GO_0051493
subclass of: GO_0060071
subclass of: GO_2000114

chondrocyte intercalation involved in growth plate cartilage morphogenesis
IAO_0000115: The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.
type: Class
subclass of: part-of-parent-3422
subclass of: part-of-parent-60029
subclass of: GO_0016477

growth plate cartilage chondrocyte morphogenesis
IAO_0000115: The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.
type: Class
subclass of: chondrocyte morphogenesis involved in endochondral bone morphogenesis
subclass of: growth plate cartilage morphogenesis
subclass of: part-of-parent-3418

growth plate cartilage chondrocyte growth
IAO_0000115: The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.
has exact synonym: growth plate cartilage chondrocyte hypertrophy
type: Class
subclass of: chondrocyte hypertrophy
subclass of: part-of-parent-3431
subclass of: GO_0060560

growth plate cartilage chondrocyte development
IAO_0000115: The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell.
type: Class
subclass of: part-of-parent-3418
subclass of: chondrocyte development involved in endochondral bone morphogenesis

cell growth involved in growth plate cartilage chondrocyte morphogenesis
IAO_0000115: The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time.
type: Class
subclass of: growth plate cartilage chondrocyte growth
subclass of: part-of-parent-3429

chondrocyte development involved in endochondral bone morphogenesis
IAO_0000115: The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.
type: Class
subclass of: chondrocyte development
subclass of: part-of-parent-3413
subclass of: part-of-parent-60350

BMP signaling pathway involved in growth plate cartilage chondrocyte development
IAO_0000115: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.
has exact synonym: BMP signalling pathway involved in growth plate cartilage chondrocyte development
type: Class
subclass of: part-of-parent-3431
subclass of: GO_0030509

smoothened signaling pathway involved in growth plate cartilage chondrocyte development
IAO_0000115: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time.
has exact synonym: hedgehog signaling pathway involved in growth plate cartilage chondrocyte development
has exact synonym: hh signaling pathway involved in growth plate cartilage chondrocyte development
has exact synonym: smoothened signalling pathway involved in growth plate cartilage chondrocyte development
type: Class
subclass of: part-of-parent-3431
subclass of: GO_0007224

regulation of cell adhesion involved in growth plate cartilage morphogenesis
IAO_0000115: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone.
type: Class
subclass of: part-of-parent-3422
subclass of: GO_0030155

regulation of cell communication involved in growth plate cartilage morphogenesis
IAO_0000115: Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage.
type: Class
subclass of: part-of-parent-3422
subclass of: GO_0010646

obsolete Gene_Ontology
IAO_0000115: OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes.
type: Class
subclass of: ObsoleteClass

molecular_function
IAO_0000115: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.
has exact synonym: molecular function
replaces: GO_0005554
type: Class

obsolete protein
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

nucleic acid binding
IAO_0000115: Interacting selectively and non-covalently with any nucleic acid.
has related synonym: base pairing
replaces: GO_0000496
type: Class
subclass of: GO_0097159
subclass of: GO_1901363

DNA binding
IAO_0000115: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has related synonym: microtubule/chromatin interaction
has related synonym: plasmid binding
has related synonym: structure specific DNA binding
has related synonym: structure-specific DNA binding
replaces: GO_0043566
type: Class
subclass of: nucleic acid binding

DNA helicase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
has exact synonym: ATP-dependent DNA helicase activity
replaces: GO_0003679
replaces: GO_0004003
type: Class
subclass of: part-of-parent-32508
subclass of: helicase activity
subclass of: GO_0008094
subclass of: GO_0140097

minor groove of adenine-thymine-rich DNA binding
IAO_0000115: Interacting selectively and non-covalently with the structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.
has exact synonym: AT DNA binding
has exact synonym: AT binding
has exact synonym: AT-rich DNA binding
type: Class
subclass of: DNA secondary structure binding

bent DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA in a bent conformation.
type: Class
subclass of: DNA binding

chromatin binding
IAO_0000115: Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
has related synonym: lamin/chromatin binding
has related synonym: microtubule/chromatin interaction
has related synonym: nuclear membrane vesicle binding to chromatin
type: Class
subclass of: GO_0005488

obsolete lamin/chromatin binding
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

damaged DNA binding
IAO_0000115: Interacting selectively and non-covalently with damaged DNA.
has related synonym: DNA repair enzyme
has related synonym: DNA repair protein
type: Class
subclass of: DNA binding

obsolete DNA repair protein
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete DNA repair enzyme
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete DNA replication factor
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

DNA replication origin binding
IAO_0000115: Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
has related synonym: ARS binding
type: Class
subclass of: GO_1990837

DNA clamp loader activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex.
has exact synonym: DNA clamp loading ATPase activity
has related synonym: PCNA loading activity
has related synonym: PCNA loading complex activity
type: Class
subclass of: DNA binding
subclass of: GO_0033170

double-stranded DNA binding
IAO_0000115: Interacting selectively and non-covalently with double-stranded DNA.
has exact synonym: dsDNA binding
type: Class
subclass of: DNA binding

double-stranded telomeric DNA binding
IAO_0000115: Interacting selectively and non-covalently with double-stranded telomere-associated DNA.
type: Class
subclass of: double-stranded DNA binding
subclass of: GO_0042162

left-handed Z-DNA binding
IAO_0000115: Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.
type: Class
subclass of: double-stranded DNA binding

P-element binding
IAO_0000115: Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis.
type: Class
subclass of: GO_1990837

obsolete plasmid binding
IAO_0000115: OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms.
type: Class
subclass of: ObsoleteClass

obsolete random coil DNA binding
IAO_0000115: OBSOLETE. Interacting selectively and non-covalently with DNA in a random coil configuration.
replaces: GO_0016017
type: Class
subclass of: ObsoleteClass

satellite DNA binding
IAO_0000115: Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.
type: Class
subclass of: GO_1990837

single-stranded DNA binding
IAO_0000115: Interacting selectively and non-covalently with single-stranded DNA.
has exact synonym: ssDNA binding
replaces: GO_0003698
replaces: GO_0003699
type: Class
subclass of: DNA binding

DNA-binding transcription factor activity
IAO_0000115: Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
has exact synonym: DNA binding transcription factor activity
has exact synonym: gene-specific transcription factor activity
has exact synonym: sequence-specific DNA binding transcription factor activity
has related synonym: bacterial-type DNA binding transcription factor activity
has related synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
has related synonym: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
has related synonym: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
has related synonym: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
has related synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has related synonym: metal ion regulated sequence-specific DNA binding transcription factor activity
has related synonym: nucleic acid binding transcription factor activity
has related synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has related synonym: transcription factor activity
has related synonym: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has related synonym: transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
has related synonym: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
has related synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding
replaces: GO_0000130
replaces: GO_0001071
replaces: GO_0001130
replaces: GO_0001131
replaces: GO_0001151
replaces: GO_0001199
replaces: GO_0001204
type: Class
subclass of: part-of-parent-6355
subclass of: GO_0140110

obsolete RNA polymerase I transcription factor activity
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase II transcription factor activity
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription.
type: Class
subclass of: ObsoleteClass

obsolete specific RNA polymerase II transcription factor activity
IAO_0000115: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II.
type: Class
subclass of: ObsoleteClass

obsolete ligand-regulated transcription factor activity
IAO_0000115: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand.
type: Class
subclass of: ObsoleteClass

steroid hormone receptor activity
IAO_0000115: Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
type: Class
subclass of: part-of-parent-43401
subclass of: GO_0038023

obsolete RNA polymerase III transcription factor activity
IAO_0000115: OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription.
type: Class
subclass of: ObsoleteClass

transcription elongation regulator activity
IAO_0000115: A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription.
has exact synonym: transcription elongation factor activity
has exact synonym: transcription elongation regulator activity
has exact synonym: transcriptional elongation regulator activity
type: Class
subclass of: GO_0140110

transcription coregulator activity
IAO_0000115: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
has exact synonym: transcription cofactor activity
has exact synonym: transcriptional co-regulator
has related synonym: RNA polymerase II transcriptional cofactor activity
replaces: GO_0001104
replaces: GO_0016455
type: Class
subclass of: part-of-parent-1903506
subclass of: GO_0140110

transcription coactivator activity
IAO_0000115: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
has exact synonym: transcription co-activator activity
has exact synonym: transcription coactivator activity
has related synonym: RNA polymerase II transcription co-activator activity
has related synonym: RNA polymerase II transcription coactivator activity
has related synonym: RNA polymerase II transcription mediator activity
replaces: GO_0001105
type: Class
subclass of: transcription coregulator activity
subclass of: part-of-parent-1903508

transcription corepressor activity
IAO_0000115: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
has exact synonym: transcription co-repressor activity
has exact synonym: transcription corepressor activity
has related synonym: RNA polymerase II transcription co-repressor activity
has related synonym: RNA polymerase II transcription corepressor activity
replaces: GO_0001106
type: Class
subclass of: transcription coregulator activity
subclass of: part-of-parent-1903507

obsolete transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase I transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase II transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II.
type: Class
subclass of: ObsoleteClass

obsolete RNA polymerase III transcription termination factor activity
IAO_0000115: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III.
type: Class
subclass of: ObsoleteClass

obsolete transcription factor binding, cytoplasmic sequestering
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

telomerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
type: Class
subclass of: RNA-directed DNA polymerase activity

telomerase RNA reverse transcriptase activity
IAO_0000115: Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.
has exact synonym: telomerase, catalyst
type: Class
subclass of: part-of-parent-3720
subclass of: RNA-directed DNA polymerase activity

RNA binding
IAO_0000115: Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
has related synonym: base pairing with RNA
has related synonym: poly(A) RNA binding
has related synonym: poly(A)-RNA binding
has related synonym: poly-A RNA binding
replaces: GO_0000498
replaces: GO_0044822
type: Class
subclass of: nucleic acid binding

RNA helicase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
has exact synonym: ATP-dependent RNA helicase activity
replaces: GO_0004004
type: Class
subclass of: helicase activity
subclass of: GO_0140098

double-stranded RNA binding
IAO_0000115: Interacting selectively and non-covalently with double-stranded RNA.
has exact synonym: dsRNA binding
type: Class
subclass of: RNA binding

double-stranded RNA adenosine deaminase activity
IAO_0000115: Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
has related synonym: double-stranded RNA specific editase activity
replaces: GO_0003971
type: Class
subclass of: adenosine deaminase activity

single-stranded RNA binding
IAO_0000115: Interacting selectively and non-covalently with single-stranded RNA.
has exact synonym: ssRNA binding
replaces: GO_0003728
type: Class
subclass of: RNA binding

mRNA binding
IAO_0000115: Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
has related synonym: base pairing with mRNA
replaces: GO_0000499
type: Class
subclass of: RNA binding

mRNA 3'-UTR binding
IAO_0000115: Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
has exact synonym: mRNA 3' UTR binding
type: Class
subclass of: mRNA binding

obsolete mRNA cap binding
IAO_0000115: OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript.
type: Class
subclass of: ObsoleteClass

obsolete snRNA cap binding
IAO_0000115: OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule.
type: Class
subclass of: ObsoleteClass

obsolete ribonucleoprotein
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete small nuclear ribonucleoprotein
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

structural constituent of ribosome
IAO_0000115: The action of a molecule that contributes to the structural integrity of the ribosome.
has related synonym: ribosomal RNA
has related synonym: ribosomal protein
replaces: GO_0003736
replaces: GO_0003737
replaces: GO_0003738
replaces: GO_0003739
replaces: GO_0003740
replaces: GO_0003741
replaces: GO_0003742
type: Class
subclass of: GO_0005198

translation initiation factor activity
IAO_0000115: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
replaces: GO_0003744
replaces: GO_0003745
type: Class
subclass of: part-of-parent-6413
subclass of: GO_0008135

translation elongation factor activity
IAO_0000115: Functions in chain elongation during polypeptide synthesis at the ribosome.
replaces: GO_0008182
replaces: GO_0008183
type: Class
subclass of: part-of-parent-6414
subclass of: GO_0008135

translation release factor activity
IAO_0000115: Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
replaces: GO_0003748
replaces: GO_0003749
type: Class
subclass of: GO_0008079

obsolete cell cycle regulator
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete chaperone activity
IAO_0000115: OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function.
replaces: GO_0003757
replaces: GO_0003758
replaces: GO_0003760
replaces: GO_0003761
type: Class
subclass of: ObsoleteClass

peptidyl-prolyl cis-trans isomerase activity
IAO_0000115: Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
has exact synonym: PPIase activity
has exact synonym: cis-trans proline isomerase activity
has exact synonym: peptide bond isomerase activity
has exact synonym: peptidylproline cis-trans-isomerase activity
has exact synonym: peptidylprolyl cis-trans isomerase activity
has exact synonym: peptidylprolyl isomerase activity
has exact synonym: rotamase activity
has related synonym: FK506-sensitive peptidyl-prolyl cis-trans isomerase
has related synonym: cyclophilin activity
has related synonym: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
has related synonym: immunophilin
has related synonym: juglone-sensitive cis-trans proline isomerase activity
has related synonym: juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
has related synonym: parvulin
has related synonym: peptidyl-prolyl isomerase B reaction
replaces: GO_0004752
replaces: GO_0042028
type: Class
subclass of: part-of-parent-413
subclass of: GO_0016859
subclass of: GO_0140096

protein disulfide isomerase activity
IAO_0000115: Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
has exact synonym: disulphide bond biosynthesis
has exact synonym: disulphide bond formation
has exact synonym: protein disulfide-isomerase reaction
has exact synonym: protein disulphide isomerase activity
has exact synonym: protein thiol-disulfide exchange
has exact synonym: protein thiol-disulphide exchange
has related synonym: S-S rearrangase activity
has related synonym: protein cysteine-thiol oxidation
has related synonym: protein disulfide-isomerase
replaces: GO_0006467
type: Class
subclass of: GO_0016864
subclass of: GO_0140096

obsolete glycoprotein-specific chaperone activity
IAO_0000115: OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins.
type: Class
subclass of: ObsoleteClass

obsolete histone-specific chaperone activity
IAO_0000115: OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function.
type: Class
subclass of: ObsoleteClass

obsolete chaperonin ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.
replaces: GO_0003764
replaces: GO_0003765
replaces: GO_0003766
type: Class
subclass of: ObsoleteClass

obsolete co-chaperone activity
IAO_0000115: OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity.
replaces: GO_0003768
replaces: GO_0003769
replaces: GO_0003770
replaces: GO_0003771
type: Class
subclass of: ObsoleteClass

obsolete co-chaperonin activity
IAO_0000115: OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity.
type: Class
subclass of: ObsoleteClass

obsolete heat shock protein activity
IAO_0000115: OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones.
type: Class
subclass of: ObsoleteClass

motor activity
IAO_0000115: Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate.
type: Class
subclass of: GO_0017111

obsolete axonemal motor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete muscle motor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

microtubule motor activity
IAO_0000115: Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
has related synonym: axonemal motor activity
has related synonym: dynein
has related synonym: dynein ATPase activity
has related synonym: kinesin
has related synonym: kinesin motor activity
has related synonym: kinetochore motor activity
type: Class
subclass of: motor activity

obsolete dynactin motor
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

actin binding
IAO_0000115: Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
has related synonym: membrane associated actin binding
type: Class
subclass of: GO_0008092

obsolete actin cross-linking activity
IAO_0000115: OBSOLETE. Interacting selectively with two actin filaments to anchor them together.
type: Class
subclass of: ObsoleteClass

obsolete actin bundling activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete F-actin capping activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete barbed-end actin capping activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete barbed-end actin capping/severing activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

actin monomer binding
IAO_0000115: Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
has exact synonym: G actin binding
type: Class
subclass of: actin binding

actin lateral binding
IAO_0000115: Interacting selectively and non-covalently with an actin filament along its length.
type: Class
subclass of: GO_0051015

obsolete actin depolymerizing activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete actin monomer sequestering activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete actin filament severing activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete actin modulating activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete membrane associated actin binding
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete regulation of actin thin filament length activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete defense/immunity protein activity
IAO_0000115: OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.
type: Class
subclass of: ObsoleteClass

obsolete acute-phase response protein activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete antimicrobial peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.
type: Class
subclass of: ObsoleteClass

lysozyme activity
IAO_0000115: Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.
has exact synonym: 1,4-N-acetylmuramidase activity
has exact synonym: N,O-diacetylmuramidase activity
has exact synonym: mucopeptide N-acetylmuramoylhydrolase activity
has exact synonym: mucopeptide glucohydrolase activity
has exact synonym: muramidase activity
has exact synonym: peptidoglycan N-acetylmuramoylhydrolase activity
has related synonym: L-7001
has related synonym: PR1-lysozyme
has related synonym: globulin G
has related synonym: globulin G1
has related synonym: lysozyme g
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds
subclass of: GO_0061783

obsolete antibacterial peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.
type: Class
subclass of: ObsoleteClass

obsolete male-specific antibacterial peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.
type: Class
subclass of: ObsoleteClass

obsolete antifungal peptide activity
IAO_0000115: OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.
type: Class
subclass of: ObsoleteClass

obsolete antiviral response protein activity
IAO_0000115: OBSOLETE. A protein involved in an antiviral response.
type: Class
subclass of: ObsoleteClass

obsolete blood coagulation factor activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete coagulation factor VIIa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.
type: Class
subclass of: ObsoleteClass

obsolete coagulation factor IXa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.
type: Class
subclass of: ObsoleteClass

obsolete coagulation factor Xa activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).
type: Class
subclass of: ObsoleteClass

obsolete coagulation factor XIa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.
type: Class
subclass of: ObsoleteClass

obsolete coagulation factor XIIa activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
type: Class
subclass of: ObsoleteClass

obsolete plasma kallikrein activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.
type: Class
subclass of: ObsoleteClass

obsolete protein C (activated) activity
IAO_0000115: OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.
type: Class
subclass of: ObsoleteClass

obsolete thrombin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
type: Class
subclass of: ObsoleteClass

protein-glutamine gamma-glutamyltransferase activity
IAO_0000115: Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
has exact synonym: R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
has exact synonym: TGase activity
has exact synonym: fibrinoligase activity
has exact synonym: glutaminylpeptide gamma-glutamyltransferase activity
has exact synonym: protein-glutamine:amine gamma-glutamyltransferase
has exact synonym: transglutaminase activity
has related synonym: factor XIIIa
has related synonym: fibrin stabilizing factor
has related synonym: polyamine transglutaminase activity
has related synonym: tissue transglutaminase
type: Class
subclass of: GO_0016755

obsolete complement activity
IAO_0000115: OBSOLETE. Any of a set of activities involved in the complement cascade.
type: Class
subclass of: ObsoleteClass

obsolete alternative-complement-pathway C3/C5 convertase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.
type: Class
subclass of: ObsoleteClass

obsolete classical-complement-pathway C3/C5 convertase activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.
type: Class
subclass of: ObsoleteClass

obsolete complement component C1r activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).
type: Class
subclass of: ObsoleteClass

obsolete complement component C1s activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
type: Class
subclass of: ObsoleteClass

obsolete complement factor D activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).
type: Class
subclass of: ObsoleteClass

obsolete complement factor I activity
IAO_0000115: OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
type: Class
subclass of: ObsoleteClass

obsolete major histocompatibility complex antigen
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete class I major histocompatibility complex antigen
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete class II major histocompatibility complex antigen
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete MHC-interacting protein
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

antigen binding
IAO_0000115: Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
has related synonym: B cell receptor activity
has related synonym: antibody
has related synonym: immunoglobulin
has related synonym: opsonin activity
type: Class
subclass of: GO_0005488

catalytic activity
IAO_0000115: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
has exact synonym: enzyme activity
type: Class
subclass of: molecular_function

alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.
has exact synonym: UDP-glucose-glucose-phosphate glucosyltransferase activity
has exact synonym: UDP-glucose-glucosephosphate glucosyltransferase activity
has exact synonym: UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
has exact synonym: UDPglucose-glucose-phosphate glucosyltransferase activity
has exact synonym: UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity
has exact synonym: alpha,alpha-trehalose phosphate synthase (UDP-forming)
has exact synonym: phosphotrehalose-uridine diphosphate transglucosylase activity
has exact synonym: transglucosylase activity
has exact synonym: trehalose 6-phosphate synthase activity
has exact synonym: trehalose 6-phosphate synthetase activity
has exact synonym: trehalose phosphate synthase activity
has exact synonym: trehalose phosphate synthetase activity
has exact synonym: trehalose phosphate-uridine diphosphate glucosyltransferase activity
has exact synonym: trehalose-P synthetase activity
has exact synonym: trehalose-phosphate synthase activity
has exact synonym: trehalose-phosphate synthetase activity
has exact synonym: trehalosephosphate-UDP glucosyl transferase activity
has exact synonym: trehalosephosphate-UDP glucosyltransferase activity
has exact synonym: uridine diphosphoglucose phosphate glucosyltransferase activity
type: Class
subclass of: GO_0035251

alpha-ketoacid dehydrogenase activity
IAO_0000115: Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid.
type: Class
subclass of: GO_0016491

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP.
has exact synonym: GNTI activity
has exact synonym: N-acetylglucosaminyltransferase I activity
has exact synonym: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
has exact synonym: UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity
has exact synonym: UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity
has exact synonym: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has exact synonym: alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity
has related synonym: GnTI
type: Class
subclass of: GO_0008375
subclass of: GO_0140103

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
has exact synonym: CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity
has exact synonym: CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity
has exact synonym: CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity
has exact synonym: GD3 synthase activity
has exact synonym: alpha-2,8-sialyltransferase activity
has exact synonym: alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity
has exact synonym: ganglioside GD3 synthase activity
has exact synonym: ganglioside GD3 synthetase sialyltransferase activity
has related synonym: SAT-2
has related synonym: cytidine monophosphoacetylneuraminate-ganglioside GM3
type: Class
subclass of: GO_0008373

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.
has exact synonym: O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity
has exact synonym: UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: beta(6)-N-acetylglucosaminyltransferase activity
has exact synonym: beta6-N-acetylglucosaminyltransferase activity
has exact synonym: core 2 acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity
has related synonym: core 6-beta-GlcNAc-transferase A
type: Class
subclass of: GO_0008375
subclass of: GO_0140103

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.
has exact synonym: GnTIII activity
has exact synonym: N-acetylglucosaminyltransferase III activity
has exact synonym: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity
has exact synonym: UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
has exact synonym: beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity
has related synonym: uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
type: Class
subclass of: GO_0008375
subclass of: GO_0140103

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.
has exact synonym: UDP-galactose--glycoprotein galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
has exact synonym: UDPgalactose-glycoprotein galactosyltransferase activity
has exact synonym: UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity
has exact synonym: beta-N-acetyl-beta-(1,4)-galactosyltransferase activity
has exact synonym: beta-N-acetyl-beta-1,4-galactosyltransferase activity
has exact synonym: glycoprotein 4-beta-galactosyl-transferase activity
has exact synonym: glycoprotein 4-beta-galactosyltransferase activity
has exact synonym: glycoprotein beta-galactosyltransferase activity
has exact synonym: uridine diphosphogalactose-glycoprotein galactosyltransferase activity
has related synonym: GalT activity
has related synonym: thyroid galactosyltransferase activity
has related synonym: thyroid glycoprotein beta-galactosyltransferase
type: Class
subclass of: GO_0035250

beta-alanyl-dopamine hydrolase activity
IAO_0000115: Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine.
has exact synonym: N-beta-alanyl-dopamine hydrolase activity
has exact synonym: NBAD hydrolase activity
type: Class
subclass of: GO_0016787

beta-alanyl-dopamine synthase activity
IAO_0000115: Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine).
has exact synonym: N-beta-alanyl dopamine synthetase activity
has exact synonym: NBAD transferase activity
type: Class
subclass of: GO_0016874

beta-carotene 15,15'-monooxygenase activity
IAO_0000115: Catalysis of the reaction: beta-carotene + O(2) = 2 retinal.
has exact synonym: beta-carotene 15,15'-dioxygenase activity
has exact synonym: beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)
has exact synonym: carotene 15,15'-dioxygenase activity
has exact synonym: carotene dioxygenase activity
type: Class
subclass of: GO_0016702

beta-galactoside alpha-2,6-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.
has exact synonym: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity
has exact synonym: CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity
has exact synonym: beta-galactosamide alpha-2,6-sialyltransferase activity
type: Class
subclass of: GO_0008373

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.
has exact synonym: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity
has exact synonym: CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity
type: Class
subclass of: GO_0008373

beta-ureidopropionase activity
IAO_0000115: Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.
has exact synonym: N-carbamoyl-beta-alanine amidohydrolase activity
type: Class
subclass of: GO_0016811

sterol 24-C-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
has exact synonym: 24-sterol C-methyltransferase activity
has exact synonym: S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity
has exact synonym: S-adenosyl-4-methionine:sterol delta24-methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity
has exact synonym: delta(24)-methyltransferase activity
has exact synonym: delta(24)-sterol C-methyltransferase activity
has exact synonym: delta(24)-sterol methyltransferase activity
has exact synonym: delta24-methyltransferase activity
has exact synonym: delta24-sterol methyltransferase activity
has related synonym: SMT1 activity
has related synonym: phytosterol methyltransferase activity
has related synonym: zymosterol-24-methyltransferase activity
type: Class
subclass of: GO_0008169
subclass of: GO_0008757

gamma-glutamylcyclotransferase activity
IAO_0000115: Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
has exact synonym: (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)
has exact synonym: L-glutamic cyclase activity
has exact synonym: gamma-L-glutamylcyclotransferase activity
has exact synonym: gamma-glutamyl-amino acid cyclotransferase activity
type: Class
subclass of: GO_0016842

obsolete gamma-glutamyltransferase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.
type: Class
subclass of: ObsoleteClass

1-acylglycerol-3-phosphate O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
has exact synonym: 1-acyl-sn-glycero-3-phosphate acyltransferase activity
has exact synonym: 1-acyl-sn-glycerol 3-phosphate acyltransferase activity
has exact synonym: 1-acyl-sn-glycerol-3-phosphate acyltransferase activity
has exact synonym: 1-acylglycero-3-phosphate acyltransferase activity
has exact synonym: 1-acylglycerolphosphate acyltransferase activity
has exact synonym: 1-acylglycerophosphate acyltransferase activity
has exact synonym: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity
has exact synonym: lysophosphatidate acyltransferase activity
has related synonym: lysophosphatidic acid-acyltransferase activity
replaces: GO_0004469
type: Class
subclass of: GO_0016411
subclass of: GO_0042171

1-pyrroline-5-carboxylate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
has exact synonym: 1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity
has exact synonym: delta1-pyrroline-5-carboxylate dehydrogenase activity
has exact synonym: pyrroline-5-carboxylate dehydrogenase activity
has exact synonym: pyrroline-5-carboxylic acid dehydrogenase activity
has related synonym: 1-pyrroline dehydrogenase
has related synonym: L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity
type: Class
subclass of: GO_0016646

1,3-beta-D-glucan synthase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
has exact synonym: (1,3)-beta-glucan (callose) synthase activity
has exact synonym: 1,3-beta-D-glucan synthetase activity
has exact synonym: 1,3-beta-D-glucan-UDP glucosyltransferase activity
has exact synonym: 1,3-beta-glucan synthase activity
has exact synonym: 1,3-beta-glucan-uridine diphosphoglucosyltransferase activity
has exact synonym: UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity
has exact synonym: UDP-glucose-1,3-beta-glucan glucosyltransferase activity
has exact synonym: UDP-glucose-beta-glucan glucosyltransferase activity
has exact synonym: UDP-glucose:(1,3)beta-glucan synthase activity
has exact synonym: UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
has exact synonym: UDPglucose-1,3-beta-D-glucan glucosyltransferase activity
has exact synonym: UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity
has exact synonym: beta-1,3-glucan synthase activity
has exact synonym: beta-1,3-glucan synthetase activity
has exact synonym: callose synthase activity
has exact synonym: callose synthetase activity
has exact synonym: uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity
has related synonym: GS-II
has related synonym: paramylon synthetase
replaces: GO_0009981
type: Class
subclass of: GO_0035251

1,4-alpha-glucan branching enzyme activity
IAO_0000115: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
has exact synonym: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity
has exact synonym: 1,4-glucan-6-(1,4-glucano)-transferase activity
has exact synonym: alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity
has exact synonym: alpha-glucan-branching glycosyltransferase activity
has exact synonym: amylo-(1,4 to 1,6)transglucosidase activity
has exact synonym: amylo-(1,4->1,6)-transglycosylase activity
has exact synonym: amylose isomerase activity
has exact synonym: branching glycosyltransferase activity
has exact synonym: glucosan transglycosylase activity
has exact synonym: glycogen branching enzyme activity
has related synonym: Q-enzyme
has related synonym: branching enzyme activity
has related synonym: enzymatic branching factor
has related synonym: enzyme Q
has related synonym: plant branching enzyme
has related synonym: starch branching enzyme
type: Class
subclass of: GO_0016758

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
IAO_0000115: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+).
has exact synonym: 11beta-hydroxy steroid dehydrogenase
has exact synonym: 11beta-hydroxysteroid dehydrogenase
has exact synonym: dehydrogenase, 11beta-hydroxy steroid
has related synonym: beta-hydroxysteroid dehydrogenase
has related synonym: corticosteroid 11-reductase
has related synonym: corticosteroid 11beta-dehydrogenase
type: Class
subclass of: GO_0033764

2-acylglycerol O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
has exact synonym: acyl coenzyme A-monoglyceride acyltransferase activity
has exact synonym: acyl-CoA:2-acylglycerol O-acyltransferase activity
has exact synonym: acylglycerol palmitoyltransferase activity
has exact synonym: monoacylglycerol acyltransferase activity
has exact synonym: monoglyceride acyltransferase activity
type: Class
subclass of: GO_0016411

1-alkyl-2-acetylglycerophosphocholine esterase activity
IAO_0000115: Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
has exact synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity
has exact synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity
has exact synonym: 2-acetyl-1-alkylglycerophosphocholine esterase activity
has exact synonym: alkylacetyl-GPC:acetylhydrolase activity
has related synonym: LDL-PLA(2) activity
has related synonym: LDL-PLA2
has related synonym: LDL-associated phospholipase A(2) activity
has related synonym: LDL-associated phospholipase A2
has related synonym: PAF 2-acylhydrolase activity
has related synonym: PAF acetylhydrolase activity
has related synonym: platelet-activating factor acetylhydrolase activity
type: Class
subclass of: GO_0052689

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
has exact synonym: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
has exact synonym: 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
has exact synonym: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
has exact synonym: 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
has exact synonym: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
has exact synonym: 7,8-dihydroxymethylpterin-pyrophosphokinase activity
has exact synonym: ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
has exact synonym: H2-pteridine-CH2OH pyrophosphokinase activity
has exact synonym: hydroxymethyldihydropteridine pyrophosphokinase activity
has related synonym: HPPK
type: Class
subclass of: GO_0016778

3-deoxy-7-phosphoheptulonate synthase activity
IAO_0000115: Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.
has exact synonym: 2-dehydro-3-deoxy-phosphoheptonate aldolase activity
has exact synonym: 2-dehydro-3-deoxyphosphoheptonate aldolase activity
has exact synonym: 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity
has exact synonym: 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity
has exact synonym: 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity
has exact synonym: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity
has exact synonym: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
has exact synonym: 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity
has exact synonym: D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity
has exact synonym: DAH7-P synthase activity
has exact synonym: DAHP synthase activity
has exact synonym: DHAP synthase activity
has exact synonym: KDPH synthase activity
has exact synonym: KDPH synthetase activity
has exact synonym: deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity
has exact synonym: phospho-2-dehydro-3-deoxyheptonate aldolase activity
has exact synonym: phospho-2-keto-3-deoxyheptanoate aldolase activity
has exact synonym: phospho-2-keto-3-deoxyheptonate aldolase activity
has exact synonym: phospho-2-keto-3-deoxyheptonic aldolase activity
has exact synonym: phospho-2-oxo-3-deoxyheptonate aldolase activity
has exact synonym: phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
has related synonym: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
has related synonym: D-erythrose-4-phosphate-lyase activity
has related synonym: DS-Co activity
has related synonym: DS-Mn activity
type: Class
subclass of: GO_0016765

2-deoxyglucose-6-phosphatase activity
IAO_0000115: Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.
has exact synonym: 2-deoxy-D-glucose-6-phosphate phosphohydrolase activity
has exact synonym: 2-deoxyglucose-6-phosphate phosphatase activity
type: Class
subclass of: GO_0050308

2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.
has exact synonym: UDP-galactose-ceramide galactosyltransferase activity
has exact synonym: UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
has exact synonym: UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity
has exact synonym: UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity
has exact synonym: UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity
has exact synonym: UDPgalactose:ceramide galactosyltransferase activity
has exact synonym: cerebroside synthase activity
has exact synonym: uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity
type: Class
subclass of: GO_0035250

2-isopropylmalate synthase activity
IAO_0000115: Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
has exact synonym: 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity
has exact synonym: acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has exact synonym: alpha-IPM synthetase activity
has exact synonym: alpha-isopropylmalate synthase activity
has exact synonym: alpha-isopropylmalate synthetase activity
has exact synonym: alpha-isopropylmalic synthetase activity
has exact synonym: isopropylmalate synthase activity
has exact synonym: isopropylmalate synthetase activity
type: Class
subclass of: GO_0046912

2-methylacyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor.
has exact synonym: 2-methyl branched chain acyl-CoA dehydrogenase activity
has exact synonym: 2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity
has exact synonym: 2-methylbutanoyl-CoA:acceptor oxidoreductase activity
has related synonym: branched-chain acyl-CoA dehydrogenase activity
type: Class
subclass of: acyl-CoA dehydrogenase activity

3-beta-hydroxy-delta5-steroid dehydrogenase activity
IAO_0000115: Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+).
has exact synonym: 3-beta-hydroxy-5-ene steroid dehydrogenase activity
has exact synonym: 3-beta-hydroxy-D5-steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy steroid dehydrogenase/isomerase activity
has exact synonym: 3beta-hydroxy-5-ene steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy-5-ene-steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy-5-ene-steroid oxidoreductase activity
has exact synonym: 3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity
has exact synonym: 3beta-hydroxy-delta5-steroid dehydrogenase activity
has exact synonym: 3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity
has exact synonym: 5-ene-3-beta-hydroxysteroid dehydrogenase activity
has exact synonym: delta5-3beta-hydroxysteroid dehydrogenase activity
has exact synonym: steroid-delta5-3beta-ol dehydrogenase activity
has related synonym: 3beta-HSDH
has related synonym: 3beta-hydroxy-delta5-C27-steroid oxidoreductase
has related synonym: progesterone reductase activity
type: Class
subclass of: GO_0033764

3-dehydroquinate dehydratase activity
IAO_0000115: Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
has exact synonym: 3-dehydroquinase activity
has exact synonym: 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
has exact synonym: 3-dehydroquinate hydro-lyase activity
has exact synonym: 3-dehydroquinate hydrolase activity
has exact synonym: 5-dehydroquinase activity
has exact synonym: 5-dehydroquinate dehydratase activity
has exact synonym: 5-dehydroquinate hydro-lyase activity
has exact synonym: DHQase
has exact synonym: dehydroquinase activity
has exact synonym: dehydroquinate dehydratase activity
type: Class
subclass of: GO_0016836

3-dehydroquinate synthase activity
IAO_0000115: Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.
type: Class
subclass of: GO_0016838

3-hydroxyacyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
has exact synonym: L-3-hydroxyacyl CoA dehydrogenase activity
has exact synonym: L-3-hydroxyacyl coenzyme A dehydrogenase activity
has exact synonym: beta-hydroxyacyl dehydrogenase activity
has exact synonym: beta-hydroxyacyl-coenzyme A synthetase activity
has exact synonym: beta-hydroxyacylcoenzyme A dehydrogenase activity
has exact synonym: beta-keto-reductase activity
has related synonym: 3-oxoacyl-thioester reductase activity
has related synonym: beta-hydroxybutyrylcoenzyme A dehydrogenase activity
has related synonym: beta-ketoacyl-CoA reductase
type: Class
subclass of: GO_0016616

3-hydroxybutyrate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
has exact synonym: D-beta-hydroxybutyrate dehydrogenase activity
type: Class
subclass of: GO_0016616

3-hydroxybutyryl-CoA dehydratase activity
IAO_0000115: Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O.
has exact synonym: (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)
has exact synonym: (3R)-3-hydroxybutanoyl-CoA hydro-lyase activity
has exact synonym: D-3-hydroxybutyryl coenzyme A dehydratase activity
has exact synonym: D-3-hydroxybutyryl-CoA dehydratase activity
has exact synonym: crotonase activity
has related synonym: enoyl coenzyme A hydrase (D)
type: Class
subclass of: GO_0016836

3-hydroxyisobutyryl-CoA hydrolase activity
IAO_0000115: Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.
has exact synonym: 3-hydroxy-2-methylpropanoyl-CoA hydrolase activity
has exact synonym: 3-hydroxy-isobutyryl CoA hydrolase activity
has exact synonym: HIB CoA deacylase activity
type: Class
subclass of: GO_0016289

3-isopropylmalate dehydratase activity
IAO_0000115: Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
has exact synonym: (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
has exact synonym: (2R,3S)-3-isopropylmalate hydro-lyase activity
has exact synonym: alpha-IPM isomerase activity
has exact synonym: alpha-isopropylmalate isomerase activity
has exact synonym: beta-isopropylmalate dehydratase activity
has exact synonym: isopropylmalate isomerase activity
type: Class
subclass of: GO_0016836

3-isopropylmalate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
has exact synonym: (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity
has exact synonym: 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity
has exact synonym: IMDH activity
has exact synonym: beta-IPM dehydrogenase activity
has exact synonym: beta-isopropylmalate dehydrogenase activity
has exact synonym: threo-Ds-3-isopropylmalate dehydrogenase activity
has related synonym: IPMDH
has related synonym: beta-isopropylmalic enzyme
type: Class
subclass of: GO_0016616

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
IAO_0000115: Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.
has exact synonym: 2-oxoisocaproate dehydrogenase activity
has exact synonym: 2-oxoisovalerate (lipoate) dehydrogenase activity
has exact synonym: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
has exact synonym: 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
has exact synonym: 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
has exact synonym: alpha-keto-alpha-methylvalerate dehydrogenase activity
has exact synonym: alpha-ketoisocaproate dehydrogenase activity
has exact synonym: alpha-ketoisocaproic dehydrogenase activity
has exact synonym: alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
has exact synonym: alpha-ketoisovalerate dehydrogenase activity
has exact synonym: alpha-oxoisocaproate dehydrogenase activity
has exact synonym: dehydrogenase, 2-oxoisovalerate (lipoate) activity
has related synonym: BCKDH activity
has related synonym: BCOAD activity
has related synonym: branched chain keto acid dehydrogenase activity
has related synonym: branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
has related synonym: branched-chain 2-keto acid dehydrogenase activity
has related synonym: branched-chain 2-oxo acid dehydrogenase activity
has related synonym: branched-chain alpha-keto acid dehydrogenase activity
has related synonym: branched-chain alpha-oxo acid dehydrogenase activity
has related synonym: branched-chain keto acid dehydrogenase activity
has related synonym: branched-chain ketoacid dehydrogenase activity
has related synonym: dehydrogenase, branched chain alpha-keto acid activity
type: Class
subclass of: GO_0016624

3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.
has exact synonym: 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity
has exact synonym: 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity
has exact synonym: alpha-ketoisovalerate hydroxymethyltransferase activity
has exact synonym: dehydropantoate hydroxymethyltransferase activity
has exact synonym: ketopantoate hydroxymethyltransferase activity
has exact synonym: oxopantoate hydroxymethyltransferase activity
type: Class
subclass of: GO_0016742

3-oxo-5-alpha-steroid 4-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.
has exact synonym: 3-keto-delta4-steroid-5alpha-reductase activity
has exact synonym: 3-oxo-5alpha-steroid 4-dehydrogenase activity
has exact synonym: 3-oxo-5alpha-steroid delta4-dehydrogenase activity
has exact synonym: 3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity
has exact synonym: 3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity
has exact synonym: 4-ene-3-ketosteroid-5alpha-oxidoreductase activity
has exact synonym: delta4-3-keto steroid 5alpha-reductase activity
has exact synonym: delta4-3-ketosteroid5alpha-oxidoreductase activity
has exact synonym: delta4-3-oxo steroid reductase activity
has exact synonym: delta4-5alpha-dehydrogenase activity
has exact synonym: steroid delta4-5alpha-reductase activity
has related synonym: 3-oxosteroid delta4-dehydrogenase
has related synonym: 5alpha-reductase
has related synonym: delta4-3-oxosteroid-5alpha-reductase
has related synonym: steroid 5 alpha reductase
has related synonym: steroid 5-alpha-reductase activity
has related synonym: steroid 5alpha-reductase
has related synonym: testosterone 5alpha-reductase
type: Class
subclass of: GO_0033765

3-phosphoshikimate 1-carboxyvinyltransferase activity
IAO_0000115: Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate.
has exact synonym: 3-enol-pyruvoylshikimate-5-phosphate synthase activity
has exact synonym: 5-enolpyruvylshikimate-3-phosphate synthase activity
has exact synonym: EPSP synthase activity
has exact synonym: phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity
type: Class
subclass of: GO_0016765

4-aminobutyrate transaminase activity
IAO_0000115: Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
has exact synonym: 4-aminobutanoate transaminase activity
has exact synonym: 4-aminobutyrate aminotransferase activity
has exact synonym: 4-aminobutyric acid aminotransferase activity
has exact synonym: GABA aminotransferase activity
has exact synonym: GABA transaminase activity
has exact synonym: GABA transferase activity
has exact synonym: aminobutyrate aminotransferase activity
has exact synonym: aminobutyrate transaminase activity
has exact synonym: gamma-amino-N-butyrate transaminase activity
has exact synonym: gamma-aminobutyrate aminotransaminase activity
has exact synonym: gamma-aminobutyrate transaminase activity
has exact synonym: gamma-aminobutyric acid aminotransferase activity
has exact synonym: gamma-aminobutyric acid transaminase activity
has exact synonym: gamma-aminobutyric transaminase activity
has exact synonym: glutamate-succinic semialdehyde transaminase activity
has related synonym: beta-alanine aminotransferase
type: Class
subclass of: GO_0008483

4-hydroxyphenylpyruvate dioxygenase activity
IAO_0000115: Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
has exact synonym: 4-hydroxyphenylpyruvate hydroxylase activity
has exact synonym: 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)
has exact synonym: 4-hydroxyphenylpyruvic acid dioxygenase activity
has exact synonym: p-hydroxyphenylpyruvate dioxygenase activity
has exact synonym: p-hydroxyphenylpyruvate hydroxylase activity
has exact synonym: p-hydroxyphenylpyruvate oxidase activity
has exact synonym: p-hydroxyphenylpyruvic acid hydroxylase activity
has exact synonym: p-hydroxyphenylpyruvic hydroxylase activity
has exact synonym: p-hydroxyphenylpyruvic oxidase activity
type: Class
subclass of: GO_0016702

5-aminolevulinate synthase activity
IAO_0000115: Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
has exact synonym: 5-aminolevulinate synthetase activity
has exact synonym: 5-aminolevulinic acid synthase activity
has exact synonym: 5-aminolevulinic acid synthetase activity
has exact synonym: ALA synthase activity
has exact synonym: ALA synthetase activity
has exact synonym: ALAS activity
has exact synonym: alpha-aminolevulinic acid synthase activity
has exact synonym: aminolevulinate synthase activity
has exact synonym: aminolevulinate synthetase activity
has exact synonym: aminolevulinic acid synthase activity
has exact synonym: aminolevulinic acid synthetase activity
has exact synonym: aminolevulinic synthetase activity
has exact synonym: delta-ALA synthetase activity
has exact synonym: delta-aminolevulinate synthase activity
has exact synonym: delta-aminolevulinate synthetase activity
has exact synonym: delta-aminolevulinic acid synthase activity
has exact synonym: delta-aminolevulinic acid synthetase activity
has exact synonym: delta-aminolevulinic synthetase activity
has exact synonym: succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
type: Class
subclass of: GO_0016749

5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
IAO_0000115: Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
has exact synonym: 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity
has exact synonym: cobalamin-independent methionine synthase activity
has exact synonym: homocysteine methylase activity
has exact synonym: methionine synthase (cobalamin-independent) activity
has exact synonym: methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity
has exact synonym: methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity
has exact synonym: tetrahydropteroylglutamate-homocysteine transmethylase activity
has exact synonym: tetrahydropteroyltriglutamate methyltransferase activity
has related synonym: MetE
type: Class
subclass of: GO_0008172
subclass of: GO_0042085

6-phosphofructokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
has exact synonym: 6-phosphofructokinase reduction
has exact synonym: 6-phosphofructose 1-kinase activity
has exact synonym: ATP-dependent phosphofructokinase activity
has exact synonym: ATP:D-fructose-6-phosphate 1-phosphotransferase activity
has exact synonym: D-fructose-6-phosphate 1-phosphotransferase activity
has exact synonym: fructose 6-phosphate kinase activity
has exact synonym: fructose 6-phosphokinase activity
has exact synonym: nucleotide triphosphate-dependent phosphofructokinase activity
has exact synonym: phospho-1,6-fructokinase activity
has exact synonym: phosphofructokinase (phosphorylating)
has exact synonym: phosphofructokinase I activity
has related synonym: PFK
has related synonym: phosphohexokinase activity
type: Class
subclass of: part-of-parent-61615
subclass of: GO_0008443

6-phosphofructo-2-kinase activity
IAO_0000115: Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
has exact synonym: 6-phosphofructo-2-kinase (phosphorylating)
has exact synonym: 6-phosphofructose 2-kinase activity
has exact synonym: ATP:D-fructose-6-phosphate 2-phosphotransferase activity
has exact synonym: ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity
has exact synonym: fructose 6-phosphate 2-kinase activity
has exact synonym: phosphofructokinase 2 activity
type: Class
subclass of: GO_0008443

6-pyruvoyltetrahydropterin synthase activity
IAO_0000115: Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate.
has exact synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity
has exact synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
has exact synonym: 6-pyruvoyl tetrahydrobiopterin synthase activity
has exact synonym: PTPS activity
type: Class
subclass of: GO_0016838

ADP-ribosylarginine hydrolase activity
IAO_0000115: Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose.
has exact synonym: ADP-ribose-L-arginine cleavage enzyme activity
has exact synonym: ADP-ribose-L-arginine cleaving enzyme activity
has exact synonym: ADPribosylarginine hydrolase activity
has exact synonym: N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has exact synonym: nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has exact synonym: omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
has exact synonym: protein ADP-ribosylarginine hydrolase activity
has exact synonym: protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity
type: Class
subclass of: GO_0016799

AMP deaminase activity
IAO_0000115: Catalysis of the reaction: AMP + H2O = IMP + NH3.
has exact synonym: 5-AMP deaminase activity
has exact synonym: 5-adenylate deaminase activity
has exact synonym: 5-adenylic acid deaminase activity
has exact synonym: AMP aminase activity
has exact synonym: AMP aminohydrolase activity
has exact synonym: adenosine 5-monophosphate deaminase activity
has exact synonym: adenosine 5-phosphate aminohydrolase activity
has exact synonym: adenosine monophosphate deaminase activity
has exact synonym: adenyl deaminase activity
has exact synonym: adenylate aminohydrolase activity
has exact synonym: adenylate deaminase activity
has exact synonym: adenylate deaminase reaction
has exact synonym: adenylate desaminase activity
has exact synonym: adenylic acid deaminase activity
has exact synonym: adenylic deaminase activity
has related synonym: myoadenylate deaminase activity
type: Class
subclass of: GO_0047623

ATP adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
has exact synonym: ADP:ATP adenylyltransferase activity
has exact synonym: AP-4-A phosphorylase activity
has exact synonym: adenine triphosphate adenylyltransferase activity
has exact synonym: bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity
has exact synonym: diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity
has exact synonym: diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)
has exact synonym: diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity
has exact synonym: diadenosinetetraphosphate alpha-beta-phosphorylase activity
has exact synonym: diadenosinetetraphosphate alphabeta-phosphorylase activity
has exact synonym: dinucleoside oligophosphate alphabeta-phosphorylase activity
type: Class
subclass of: GO_0070566

ATP citrate synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA.
has exact synonym: ATP citrate (pro-S)-lyase activity
has exact synonym: ATP-citrate (pro-S)-lyase activity
has exact synonym: ATP-citrate (pro-S-)-lyase activity
has exact synonym: ATP-citric lyase activity
has exact synonym: ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity
has exact synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity
has exact synonym: acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
has exact synonym: adenosine triphosphate citrate lyase activity
has exact synonym: citrate-ATP lyase activity
has related synonym: ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)
has related synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
has related synonym: citrate cleavage enzyme activity
has related synonym: citric cleavage enzyme activity
replaces: GO_0046913
type: Class
subclass of: GO_0046912

ATP phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
has exact synonym: 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity
has exact synonym: adenosine triphosphate phosphoribosyltransferase activity
has exact synonym: phosphoribosyl ATP synthetase activity
has exact synonym: phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity
has exact synonym: phosphoribosyl-ATP diphosphorylase activity
has exact synonym: phosphoribosyl-ATP pyrophosphorylase activity
has exact synonym: phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity
has exact synonym: phosphoribosyladenosine triphosphate pyrophosphorylase activity
has exact synonym: phosphoribosyladenosine triphosphate synthetase activity
has exact synonym: phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity
type: Class
subclass of: GO_0016763

protein C-terminal carboxyl O-methyltransferase activity
IAO_0000115: Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.
has exact synonym: C-terminal protein carboxyl methyltransferase activity
type: Class
subclass of: part-of-parent-6481
subclass of: GO_0051998

CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
IAO_0000115: Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+).
has exact synonym: CDP diglyceride-inositol phosphatidyltransferase activity
has exact synonym: CDP-DG:inositol transferase activity
has exact synonym: CDP-diacylglycerol--inositol phosphatidyltransferase activity
has exact synonym: CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity
has exact synonym: CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity
has exact synonym: CDP-diglyceride-inositol transferase activity
has exact synonym: CDP-diglyceride:inositol transferase activity
has exact synonym: CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity
has exact synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity
has exact synonym: cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity
has exact synonym: cytidine diphosphoglyceride-inositol phosphatidyltransferase activity
has exact synonym: cytidine diphosphoglyceride-inositol transferase activity
has exact synonym: phosphatidylinositol synthase activity
type: Class
subclass of: GO_0017169

CDP-diacylglycerol-serine O-phosphatidyltransferase activity
IAO_0000115: Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine.
has exact synonym: CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity
has exact synonym: CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity
has exact synonym: CDP-diglyceride-L-serine phosphatidyltransferase activity
has exact synonym: CDP-diglyceride:serine phosphatidyltransferase activity
has exact synonym: CDP-diglycerine-serine O-phosphatidyltransferase activity
has exact synonym: CDPdiacylglycerol-serine O-phosphatidyltransferase activity
has exact synonym: CDPdiglyceride-serine O-phosphatidyltransferase activity
has exact synonym: PS synthase activity
has exact synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity
has exact synonym: cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity
has exact synonym: cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity
has exact synonym: phosphatidylserine synthase activity
has exact synonym: phosphatidylserine synthetase activity
has related synonym: serine exchange enzyme
type: Class
subclass of: GO_0017169

CTP synthase activity
IAO_0000115: Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
has exact synonym: CTP synthetase activity
has exact synonym: UTP--ammonia ligase activity
has exact synonym: UTP:ammonia ligase (ADP-forming)
has exact synonym: cytidine 5'-triphosphate synthetase activity
has exact synonym: cytidine triphosphate synthetase activity
has exact synonym: uridine triphosphate aminase activity
type: Class
subclass of: GO_0016879

D-amino-acid oxidase activity
IAO_0000115: Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
has exact synonym: D-amino-acid:oxygen oxidoreductase (deaminating)
has exact synonym: L-amino acid:O2 oxidoreductase activity
has related synonym: new yellow enzyme
type: Class
subclass of: GO_0016641

D-arabinono-1,4-lactone oxidase activity
IAO_0000115: Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).
has exact synonym: D-arabinono-1,4-lactone:oxygen oxidoreductase activity
type: Class
subclass of: GO_0016899

DNA (cytosine-5-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
has exact synonym: DNA 5-cytosine methylase activity
has exact synonym: DNA cytosine C(5) methylase activity
has exact synonym: DNA cytosine C5 methylase activity
has exact synonym: DNA-cytosine 5-methylase activity
has exact synonym: S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity
has exact synonym: cytosine 5-methyltransferase activity
has exact synonym: cytosine-specific DNA methyltransferase activity
has exact synonym: deoxyribonucleic (cytosine-5-)-methyltransferase activity
has exact synonym: deoxyribonucleic acid (cytosine-5-)-methyltransferase activity
has related synonym: DNA cytosine methylase activity
has related synonym: DNA-cytosine methyltransferase activity
has related synonym: cytosine DNA methylase activity
has related synonym: cytosine DNA methyltransferase activity
has related synonym: deoxyribonucleic methylase activity
has related synonym: methylphosphotriester-DNA methyltransferase activity
has related synonym: modification methylase activity
has related synonym: restriction-modification system activity
has related synonym: site-specific DNA-methyltransferase (cytosine-specific) activity
has related synonym: type II DNA methylase activity
replaces: GO_0008326
type: Class
subclass of: part-of-parent-90116
subclass of: GO_0008757
subclass of: GO_0009008

DNA-directed DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
has exact synonym: DNA duplicase activity
has exact synonym: DNA nucleotidyltransferase (DNA-directed) activity
has exact synonym: DNA replicase activity
has exact synonym: DNA-dependent DNA polymerase activity
has exact synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity
has exact synonym: deoxyribonucleic acid duplicase activity
has exact synonym: deoxyribonucleic duplicase activity
has related synonym: DNA polymerase I
has related synonym: DNA polymerase II
has related synonym: DNA polymerase III
has related synonym: DNA polymerase V activity
has related synonym: DNA polymerase alpha
has related synonym: DNA polymerase beta
has related synonym: DNA polymerase gamma
has related synonym: Klenow fragment
has related synonym: Taq DNA polymerase
has related synonym: Taq Pol I
has related synonym: Tca DNA polymerase
has related synonym: alpha DNA polymerase activity
has related synonym: beta DNA polymerase activity
has related synonym: delta DNA polymerase activity
has related synonym: deoxyribonucleic polymerase I
has related synonym: duplicase
has related synonym: epsilon DNA polymerase activity
has related synonym: eta DNA polymerase activity
has related synonym: gamma DNA-directed DNA polymerase activity
has related synonym: iota DNA polymerase activity
has related synonym: kappa DNA polymerase activity
has related synonym: lambda DNA polymerase activity
has related synonym: mu DNA polymerase activity
has related synonym: nu DNA polymerase activity
has related synonym: sequenase
has related synonym: sigma DNA polymerase activity
has related synonym: theta DNA polymerase activity
has related synonym: zeta DNA polymerase activity
replaces: GO_0003888
replaces: GO_0003889
replaces: GO_0003890
replaces: GO_0003891
replaces: GO_0003893
replaces: GO_0003894
replaces: GO_0003895
replaces: GO_0008723
replaces: GO_0015999
replaces: GO_0016000
replaces: GO_0016448
replaces: GO_0016449
replaces: GO_0016450
replaces: GO_0016451
replaces: GO_0016452
replaces: GO_0019984
type: Class
subclass of: GO_0034061

obsolete proliferating cell nuclear antigen
IAO_0000115: OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair.
replaces: GO_0005661
type: Class
subclass of: ObsoleteClass

DNA primase activity
IAO_0000115: Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
replaces: GO_0003897
replaces: GO_0003898
type: Class
subclass of: part-of-parent-6269
subclass of: DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
has exact synonym: DNA-dependent RNA nucleotidyltransferase activity
has exact synonym: DNA-dependent RNA polymerase activity
has exact synonym: DNA-dependent ribonucleate nucleotidyltransferase activity
has exact synonym: RNA nucleotidyltransferase (DNA-directed) activity
has exact synonym: deoxyribonucleic acid-dependent ribonucleic acid polymerase activity
has exact synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity
has related synonym: C RNA formation factors
has related synonym: C ribonucleic acid formation factors
has related synonym: DNA-directed RNA polymerase I activity
has related synonym: DNA-directed RNA polymerase II activity
has related synonym: DNA-directed RNA polymerase III activity
has related synonym: DNA-directed RNA polymerase activity
has related synonym: RNA polymerase I activity
has related synonym: RNA polymerase II activity
has related synonym: RNA polymerase III activity
has related synonym: transcriptase
replaces: GO_0000129
type: Class
subclass of: part-of-parent-32774
subclass of: GO_0034062

obsolete DNA-directed RNA polymerase I activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
type: Class
subclass of: ObsoleteClass

obsolete DNA-directed RNA polymerase II activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
type: Class
subclass of: ObsoleteClass

obsolete DNA-directed RNA polymerase III activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
type: Class
subclass of: ObsoleteClass

deoxyribodipyrimidine photo-lyase activity
IAO_0000115: Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.
has exact synonym: CPD photolyase activity
has exact synonym: DNA cyclobutane dipyrimidine photolyase activity
has exact synonym: PhrB photolyase activity
has exact synonym: deoxyribocyclobutadipyrimidine pyrimidine-lyase activity
has exact synonym: deoxyribodipyrimidine photolyase activity
has exact synonym: deoxyribonucleate pyrimidine dimer lyase (photosensitive)
has exact synonym: deoxyribonucleic cyclobutane dipyrimidine photolyase activity
has exact synonym: deoxyribonucleic photolyase activity
has exact synonym: dipyrimidine photolyase (photosensitive)
has exact synonym: photolyase activity
has exact synonym: phr A photolyase activity
has related synonym: DNA-photoreactivating enzyme
has related synonym: PRE
has related synonym: photoreactivating enzyme activity
type: Class
subclass of: DNA photolyase activity

alkylbase DNA N-glycosylase activity
IAO_0000115: Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
has exact synonym: DNA glycosidase II activity
has exact synonym: DNA-3-methyladenine glycosidase II activity
has exact synonym: alkylbase DNA glycosidase activity
has related synonym: 3-methyladenine DNA glycosylase II
has related synonym: AlkA
has related synonym: DNA-3-methyladenine glycosylase II
has related synonym: alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
has related synonym: deoxyribonucleate 3-methyladenine glycosidase II
replaces: GO_0004036
type: Class
subclass of: GO_0019104

DNA-(apurinic or apyrimidinic site) endonuclease activity
IAO_0000115: Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
has exact synonym: AP deoxyendoribonuclease activity
has exact synonym: abasic deoxyendoribonuclease activity
has exact synonym: apurinic deoxyendoribonuclease activity
has exact synonym: apurinic/apyrimidinic endodeoxyribonuclease activity
has exact synonym: apyrimidinic deoxyendoribonuclease activity
has exact synonym: deoxyribonuclease (apurinic or apyrimidinic) activity
has related synonym: UV endonuclease
has related synonym: endonuclease VIII activity
type: Class
subclass of: GO_0140097

methylated-DNA-[protein]-cysteine S-methyltransferase activity
IAO_0000115: Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
has exact synonym: 6-O-methylguanine-DNA methyltransferase activity
has exact synonym: DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity
has exact synonym: DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity
has exact synonym: MGMT
has exact synonym: O-6-methylguanine-DNA-alkyltransferase activity
has exact synonym: methylated-DNA-protein-cysteine S-methyltransferase activity
has related synonym: O6-alkylguanine-DNA alkyltransferase
type: Class
subclass of: GO_0008172

DNA ligase activity
IAO_0000115: Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.
type: Class
subclass of: part-of-parent-6266
subclass of: GO_0016886
subclass of: GO_0140097

DNA ligase (ATP) activity
IAO_0000115: Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
has exact synonym: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
has exact synonym: polydeoxyribonucleotide synthase (ATP) activity
has exact synonym: polynucleotide ligase (ATP) activity
has related synonym: DNA joinase activity
has related synonym: DNA repair enzyme activity
has related synonym: DNA-joining enzyme
has related synonym: deoxyribonucleate ligase
has related synonym: deoxyribonucleic acid joinase
has related synonym: deoxyribonucleic acid ligase
has related synonym: deoxyribonucleic acid repair enzyme
has related synonym: deoxyribonucleic acid-joining enzyme
has related synonym: deoxyribonucleic joinase
has related synonym: deoxyribonucleic ligase
has related synonym: deoxyribonucleic repair enzyme
has related synonym: deoxyribonucleic-joining enzyme
has related synonym: polynucleotide ligase
has related synonym: sealase activity
type: Class
subclass of: DNA ligase activity

DNA ligase (NAD+) activity
IAO_0000115: Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
has exact synonym: DNA ligase (NAD)
has exact synonym: Polydeoxyribonucleotide synthase (NAD(+)) activity
has exact synonym: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
has exact synonym: polydeoxyribonucleotide synthase (NAD)
has exact synonym: polydeoxyribonucleotide synthase (NAD+) activity
has exact synonym: polynucleotide ligase (NAD(+)) activity
has exact synonym: polynucleotide ligase (NAD)
has exact synonym: polynucleotide ligase (NAD+) activity
has exact synonym: polynucleotide ligase (nicotinamide adenine dinucleotide)
has exact synonym: polynucleotide synthetase (nicotinamide adenine dinucleotide)
has exact synonym: polynucleotide synthetase activity
has related synonym: DNA joinase activity
has related synonym: DNA repair enzyme activity
has related synonym: DNA-joining enzyme
has related synonym: deoxyribonucleate ligase
has related synonym: deoxyribonucleic acid joinase
has related synonym: deoxyribonucleic acid ligase
has related synonym: deoxyribonucleic joinase
has related synonym: deoxyribonucleic ligase
has related synonym: deoxyribonucleic repair enzyme
has related synonym: deoxyribonucleic-joining enzyme
has related synonym: polynucleotide ligase
type: Class
subclass of: DNA ligase activity

DNA nucleotidylexotransferase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
has exact synonym: addase activity
has exact synonym: deoxynucleotidyl terminal transferase activity
has exact synonym: deoxyribonucleic acid nucleotidyltransferase activity
has exact synonym: deoxyribonucleic nucleotidyltransferase activity
has exact synonym: nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity
has exact synonym: terminal deoxynucleotide transferase activity
has exact synonym: terminal deoxynucleotidyltransferase activity
has exact synonym: terminal deoxyribonucleotidyltransferase activity
has exact synonym: terminal transferase activity
has related synonym: TdT
has related synonym: terminal addition enzyme activity
type: Class
subclass of: GO_0016779
subclass of: GO_0140097

DNA photolyase activity
IAO_0000115: Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA.
type: Class
subclass of: GO_0016830
subclass of: GO_0140097

DNA (6-4) photolyase activity
IAO_0000115: Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA.
type: Class
subclass of: DNA photolyase activity

DNA topoisomerase activity
IAO_0000115: Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
replaces: GO_0009387
type: Class
subclass of: GO_0016853
subclass of: GO_0140097

DNA topoisomerase type I (single strand cut, ATP-independent) activity
IAO_0000115: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
has exact synonym: type I DNA topoisomerase activity
has exact synonym: type I topoisomerase activity
has related synonym: DNA topoisomerase I activity
has related synonym: deoxyribonucleate topoisomerase
has related synonym: nicking-closing enzyme activity
has related synonym: omega-protein activity
has related synonym: relaxing enzyme activity
has related synonym: swivelase activity
has related synonym: topoisomerase
has related synonym: untwisting enzyme activity
type: Class
subclass of: DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
IAO_0000115: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
has exact synonym: DNA topoisomerase (ATP-hydrolysing)
has exact synonym: DNA topoisomerase type II activity
has exact synonym: type II DNA topoisomerase activity
has related synonym: DNA topoisomerase II
has related synonym: DNA topoisomerase II activity
has related synonym: DNA topoisomerase IV activity
has related synonym: deoxyribonucleate topoisomerase
has related synonym: deoxyribonucleic topoisomerase activity
has related synonym: topoisomerase
has related synonym: topoisomerase II
replaces: GO_0061505
type: Class
subclass of: DNA topoisomerase activity
subclass of: GO_0008094

FMN adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + FMN = diphosphate + FAD.
has exact synonym: ATP:FMN adenylyltransferase activity
has exact synonym: FAD diphosphorylase activity
has exact synonym: FAD pyrophosphorylase activity
has exact synonym: FAD synthetase activity
has exact synonym: adenosine triphosphate-riboflavin mononucleotide transadenylase activity
has exact synonym: adenosine triphosphate-riboflavine mononucleotide transadenylase activity
has exact synonym: flavin adenine dinucleotide synthetase activity
has exact synonym: riboflavin adenine dinucleotide pyrophosphorylase activity
has exact synonym: riboflavin mononucleotide adenylyltransferase activity
has exact synonym: riboflavine adenine dinucleotide adenylyltransferase activity
type: Class
subclass of: GO_0070566

GMP reductase activity
IAO_0000115: Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH.
has exact synonym: NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)
has exact synonym: NADPH:GMP oxidoreductase (deaminating) activity
has exact synonym: NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity
has exact synonym: guanosine 5'-monophosphate oxidoreductase activity
has exact synonym: guanosine 5'-monophosphate reductase activity
has exact synonym: guanosine 5'-phosphate reductase activity
has exact synonym: guanosine monophosphate reductase activity
has exact synonym: inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
has related synonym: guanylate reductase activity
type: Class
subclass of: GO_0016657

GMP synthase activity
IAO_0000115: Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
type: Class
subclass of: part-of-parent-3922
subclass of: GO_0016879

GMP synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+).
has exact synonym: GMP synthase (glutamine-hydrolysing)
has exact synonym: GMP synthetase (glutamine-hydrolysing)
has exact synonym: GMP synthetase (glutamine-hydrolyzing) activity
has exact synonym: glutamine amidotransferase activity
has exact synonym: guanosine 5'-monophosphate synthetase activity
has exact synonym: guanosine monophosphate synthetase (glutamine-hydrolyzing)
has exact synonym: guanylate synthetase (glutamine-hydrolyzing)
has exact synonym: xanthosine 5'-phosphate amidotransferase activity
has exact synonym: xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
type: Class
subclass of: part-of-parent-6177
subclass of: GO_0016884

GPI-anchor transamidase activity
IAO_0000115: Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.
type: Class
subclass of: cysteine-type endopeptidase activity

GTPase activity
IAO_0000115: Catalysis of the reaction: GTP + H2O = GDP + phosphate.
has related synonym: ARF small monomeric GTPase activity
has related synonym: GTPase activity, coupled
has related synonym: RHEB small monomeric GTPase activity
has related synonym: Rab small monomeric GTPase activity
has related synonym: Ran small monomeric GTPase activity
has related synonym: Ras small monomeric GTPase activity
has related synonym: Rho small monomeric GTPase activity
has related synonym: Sar small monomeric GTPase activity
has related synonym: dynamin GTPase activity
has related synonym: heterotrimeric G-protein GTPase activity
has related synonym: heterotrimeric G-protein GTPase, alpha-subunit
has related synonym: heterotrimeric G-protein GTPase, beta-subunit
has related synonym: heterotrimeric G-protein GTPase, gamma-subunit
has related synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
has related synonym: protein-synthesizing GTPase activity
has related synonym: protein-synthesizing GTPase activity, elongation
has related synonym: protein-synthesizing GTPase activity, initiation
has related synonym: protein-synthesizing GTPase activity, termination
has related synonym: signal-recognition-particle GTPase activity
has related synonym: small monomeric GTPase activity
has related synonym: tubulin GTPase activity
replaces: GO_0061745
type: Class
subclass of: GO_0017111

obsolete small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
type: Class
subclass of: ObsoleteClass

obsolete ARF small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete heterotrimeric G-protein GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase.
type: Class
subclass of: ObsoleteClass

obsolete RAB small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete RAN small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete RAS small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete Rho small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
type: Class
subclass of: ObsoleteClass

obsolete SAR small monomeric GTPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
type: Class
subclass of: ObsoleteClass

GTP cyclohydrolase activity
IAO_0000115: Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.
type: Class
subclass of: GO_0019238

GTP cyclohydrolase I activity
IAO_0000115: Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
has exact synonym: GTP 7,8-8,9-dihydrolase activity
has exact synonym: GTP 8-formylhydrolase activity
has exact synonym: dihydroneopterin triphosphate synthase activity
has exact synonym: guanosine triphosphate 8-deformylase activity
has exact synonym: guanosine triphosphate cyclohydrolase activity
type: Class
subclass of: GTP cyclohydrolase activity

GTP cyclohydrolase II activity
IAO_0000115: Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+).
has exact synonym: GTP 7,8-8,9-dihydrolase (diphosphate-forming)
has exact synonym: GTP-8-formylhydrolase activity
has related synonym: guanosine triphosphate cyclohydrolase II
type: Class
subclass of: GTP cyclohydrolase activity

obsolete hydrogen-transporting two-sector ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out).
replaces: GO_0004006
replaces: GO_0008729
type: Class
subclass of: ObsoleteClass

IMP cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
has exact synonym: IMP 1,2-hydrolase (decyclizing)
has exact synonym: IMP synthetase activity
has exact synonym: inosinate cyclohydrolase activity
has exact synonym: inosinicase activity
type: Class
subclass of: GO_0019238

IMP dehydrogenase activity
IAO_0000115: Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
has exact synonym: IMP oxidoreductase activity
has exact synonym: IMP:NAD+ oxidoreductase activity
has exact synonym: inosine 5'-monophosphate dehydrogenase activity
has exact synonym: inosine monophosphate dehydrogenase activity
has exact synonym: inosine monophosphate oxidoreductase activity
has exact synonym: inosine-5'-phosphate dehydrogenase activity
has related synonym: inosinate dehydrogenase activity
has related synonym: inosinic acid dehydrogenase activity
type: Class
subclass of: GO_0016616

L-iditol 2-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
has exact synonym: L-iditol:NAD oxidoreductase activity
has exact synonym: L-iditol:NAD+ 5-oxidoreductase activity
has related synonym: L-iditol (sorbitol) dehydrogenase activity
has related synonym: NAD+-dependent sorbitol dehydrogenase activity
has related synonym: NAD-dependent sorbitol dehydrogenase activity
has related synonym: NAD-sorbitol dehydrogenase
has related synonym: glucitol dehydrogenase activity
has related synonym: polyol dehydrogenase activity
has related synonym: sorbitol dehydrogenase activity
type: Class
subclass of: GO_0016616

L-iduronidase activity
IAO_0000115: Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate.
has exact synonym: alpha-L-iduronidase activity
has exact synonym: glycosaminoglycan alpha-L-iduronohydrolase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

L-serine ammonia-lyase activity
IAO_0000115: Catalysis of the reaction: L-serine = pyruvate + NH3.
has exact synonym: L-serine ammonia-lyase (pyruvate-forming) activity
has exact synonym: L-serine deaminase activity
has exact synonym: L-serine hydro-lyase (deaminating) activity
has related synonym: L-hydroxyaminoacid dehydratase activity
has related synonym: L-serine dehydratase activity
has related synonym: L-serine dehydration activity
has related synonym: serine deaminase activity
type: Class
subclass of: GO_0016841

N-acetyl-gamma-glutamyl-phosphate reductase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
has exact synonym: N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
has exact synonym: N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
has exact synonym: N-acetyl-glutamate semialdehyde dehydrogenase activity
has exact synonym: N-acetylglutamate 5-semialdehyde dehydrogenase activity
has exact synonym: N-acetylglutamic gamma-semialdehyde dehydrogenase activity
has exact synonym: reductase, acetyl-gamma-glutamyl phosphate
has related synonym: NAGSA dehydrogenase activity
type: Class
subclass of: GO_0016620

N-acetylgalactosamine-4-sulfatase activity
IAO_0000115: Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.
has exact synonym: N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity
has exact synonym: N-acetylgalactosamine 4-sulfate sulfohydrolase activity
has exact synonym: N-acetylgalactosamine-4-sulphatase activity
has exact synonym: acetylgalactosamine 4-sulfatase activity
has exact synonym: arylsulfatase B
has related synonym: chondroitinsulfatase
type: Class
subclass of: GO_0008484

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
IAO_0000115: Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.
has exact synonym: 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity
has exact synonym: alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity
has exact synonym: alpha-N-acetylglucosaminyl phosphodiesterase activity
has exact synonym: glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity
has exact synonym: phosphodiester glycosidase activity
has related synonym: lysosomal alpha-N-acetylglucosaminidase activity
type: Class
subclass of: GO_0015929

N-acetyllactosamine synthase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
has exact synonym: N-acetylglucosamine (beta-1,4)galactosyltransferase activity
has exact synonym: N-acetylglucosamine beta-(1,4)-galactosyltransferase activity
has exact synonym: N-acetyllactosamine synthetase activity
has exact synonym: NAL synthetase activity
has exact synonym: UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity
has exact synonym: UDP-beta-1,4-galactosyltransferase activity
has exact synonym: UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity
has exact synonym: UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity
has exact synonym: UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity
has exact synonym: UDP-galactose-N-acetylglucosamine galactosyltransferase activity
has exact synonym: UDP-galactose-acetylglucosamine galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
has exact synonym: UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity
has exact synonym: UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity
has exact synonym: UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity
has exact synonym: UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity
has exact synonym: acetyllactosamine synthetase activity
has exact synonym: beta-(1,4)-galactosyltransferase activity
has exact synonym: beta-1,4-galactosyltransferase activity
has exact synonym: beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity
has exact synonym: lactosamine synthase activity
has exact synonym: lactosamine synthetase activity
has exact synonym: uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity
has related synonym: Gal-T
has related synonym: beta-1,4-GalT
has related synonym: lactose synthetase A protein
type: Class
subclass of: GO_0035250

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.
has exact synonym: GM2 synthase activity
has exact synonym: GM2/GD2-synthase activity
has exact synonym: GalNAc-T activity
has exact synonym: UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity
has exact synonym: asialo-GM2 synthase activity
has exact synonym: beta-1,4N-aetylgalactosaminyltransferase activity
has exact synonym: ganglioside GM2 synthase activity
has exact synonym: ganglioside GM3 acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity
type: Class
subclass of: GO_0008376

N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
IAO_0000115: Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).
has exact synonym: 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
has exact synonym: N-aspartyl-beta-glucosaminidase activity
has exact synonym: N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity
has exact synonym: aspartylglucosaminidase activity
has exact synonym: aspartylglucosylaminase activity
has exact synonym: aspartylglucosylamine deaspartylase activity
has exact synonym: aspartylglucosylaminidase activity
has exact synonym: aspartylglycosylamine amidohydrolase activity
has exact synonym: beta-aspartylglucosylamine amidohydrolase activity
has exact synonym: glycosylasparaginase activity
has related synonym: glucosylamidase activity
type: Class
subclass of: GO_0016811

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
IAO_0000115: Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
has exact synonym: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity
has exact synonym: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity
has exact synonym: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity
has exact synonym: N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity
has exact synonym: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity
has exact synonym: phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity
type: Class
subclass of: GO_0016861

NAD+ ADP-ribosyltransferase activity
IAO_0000115: Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
has exact synonym: ADP-ribosyltransferase (polymerizing) activity
has exact synonym: NAD ADP-ribosyltransferase activity
has exact synonym: NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity
has exact synonym: poly(ADP-ribose) synthase activity
has exact synonym: poly(ADP-ribose) synthetase activity
has exact synonym: poly(ADP-ribose)polymerase activity
has exact synonym: poly(adenosine diphosphate ribose) polymerase activity
type: Class
subclass of: GO_0016763

NAD+ kinase activity
IAO_0000115: Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+).
has exact synonym: ATP:NAD+ 2'-phosphotransferase activity
has exact synonym: NAD kinase activity
has exact synonym: nicotinamide adenine dinucleotide kinase (phosphorylating)
has exact synonym: nicotinamide adenine dinucleotide kinase activity
has related synonym: DPN kinase activity
has related synonym: NADK
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

NAD+ synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.
has exact synonym: DPN synthetase activity
has exact synonym: NAD synthase (glutamine-hydrolyzing) activity
has exact synonym: NAD synthetase (glutamine-hydrolysing)
has exact synonym: NAD(+) synthetase (glutamine-hydrolyzing) activity
has exact synonym: NAD+ synthase (glutamine-hydrolysing)
has exact synonym: NAD+ synthetase (glutamine-hydrolyzing)
has exact synonym: deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
has exact synonym: desamidonicotinamide adenine dinucleotide amidotransferase activity
has exact synonym: nicotinamide adenine dinucleotide synthetase (glutamine) activity
type: Class
subclass of: GO_0016884

NAD+ nucleosidase activity
IAO_0000115: Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.
has exact synonym: NAD nucleosidase activity
type: Class
subclass of: GO_0016799

NADH dehydrogenase activity
IAO_0000115: Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
has exact synonym: DPNH diaphorase activity
has exact synonym: NADH diaphorase activity
has exact synonym: NADH hydrogenase activity
has exact synonym: NADH oxidoreductase activity
has exact synonym: NADH2 dehydrogenase activity
has exact synonym: NADH:(acceptor) oxidoreductase activity
has exact synonym: NADH:acceptor oxidoreductase activity
has exact synonym: beta-NADH dehydrogenase dinucleotide activity
has exact synonym: dihydrocodehydrogenase I dehydrogenase activity
has exact synonym: dihydronicotinamide adenine dinucleotide dehydrogenase activity
has exact synonym: diphosphopyridine diaphorase activity
has exact synonym: diphosphopyrinase activity
has exact synonym: reduced diphosphopyridine nucleotide diaphorase activity
has related synonym: NADH-menadione oxidoreductase activity
has related synonym: NADH:cytochrome c oxidoreductase activity
has related synonym: cytochrome c reductase activity
has related synonym: diaphorase activity
has related synonym: type 1 dehydrogenase activity
has related synonym: type I dehydrogenase activity
type: Class
subclass of: GO_0016651

NAD(P)H dehydrogenase (quinone) activity
IAO_0000115: Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.
has exact synonym: DT-diaphorase activity
has exact synonym: NAD(P)H(2) dehydrogenase (quinone) activity
has exact synonym: NAD(P)H-quinone dehydrogenase activity
has exact synonym: NAD(P)H-quinone oxidoreductase activity
has exact synonym: NAD(P)H2 dehydrogenase (quinone)
has exact synonym: NAD(P)H:(quinone-acceptor)oxidoreductase activity
has exact synonym: NAD(P)H:quinone oxidoreductase activity
has exact synonym: dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity
has exact synonym: flavoprotein NAD(P)H-quinone reductase activity
has exact synonym: quinone reductase activity
has exact synonym: reduced NAD(P)H dehydrogenase activity
has exact synonym: reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity
has related synonym: NAD(P)H dehydrogenase activity
has related synonym: NAD(P)H menadione reductase activity
has related synonym: NAD(P)H: menadione oxidoreductase activity
has related synonym: NADH-menadione reductase activity
has related synonym: NQO1
has related synonym: Naphthoquinone reductase activity
has related synonym: QR1
has related synonym: azoreductase activity
has related synonym: diaphorase activity
has related synonym: menadione oxidoreductase activity
has related synonym: menadione reductase activity
has related synonym: naphthoquinone reductase activity
has related synonym: p-benzoquinone reductase activity
has related synonym: phylloquinone reductase activity
has related synonym: viologen accepting pyridine nucleotide oxidoreductase activity
has related synonym: vitamin K reductase activity
has related synonym: vitamin-K reductase activity
type: Class
subclass of: GO_0016655

NAD(P)+-protein-arginine ADP-ribosyltransferase activity
IAO_0000115: Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.
has exact synonym: NAD(+):L-arginine ADP-D-ribosyltransferase activity
has exact synonym: NAD(P)(+)--arginine ADP-ribosyltransferase activity
has exact synonym: NAD(P)+-arginine ADP-ribosyltransferase activity
has exact synonym: NAD(P)+:L-arginine ADP-D-ribosyltransferase activity
has exact synonym: NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity
has exact synonym: NAD(P)-arginine ADP-ribosyltransferase activity
has exact synonym: NAD+:L-arginine ADP-D-ribosyltransferase activity
has exact synonym: peptidyl-arginine ADP-ribosylation activity
has exact synonym: protein-arginine ADP-ribosyltransferase activity
has related synonym: ADP-ribosyltransferase activity
has related synonym: mono(ADP-ribosyl)transferase activity
has related synonym: mono(ADPribosyl)transferase activity
type: Class
subclass of: GO_0016763

NAD(P)+ transhydrogenase (B-specific) activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
has exact synonym: NAD(P) transhydrogenase (B-specific) activity
has exact synonym: NADPH:NAD+ oxidoreductase (B-specific)
has exact synonym: non-energy-linked transhydrogenase activity
has related synonym: H+-thase
has related synonym: NAD transhydrogenase
has related synonym: NADH transhydrogenase
has related synonym: NADH-NADP-transhydrogenase
has related synonym: NADPH-NAD oxidoreductase
has related synonym: NADPH-NAD transhydrogenase
has related synonym: NADPH:NAD+ transhydrogenase
has related synonym: nicotinamide adenine dinucleotide (phosphate) transhydrogenase
has related synonym: nicotinamide nucleotide transhydrogenase activity
has related synonym: pyridine nucleotide transferase
has related synonym: pyridine nucleotide transhydrogenase activity
type: Class
subclass of: GO_0008746
subclass of: GO_0015078

NADPH-hemoprotein reductase activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
has exact synonym: NADPH-cytochrome P-450 oxidoreductase activity
has exact synonym: NADPH-cytochrome p-450 reductase activity
has exact synonym: NADPH-ferrihemoprotein reductase activity
has exact synonym: NADPH:P-450 reductase activity
has exact synonym: NADPH:cytochrome P450 reductase activity
has exact synonym: NADPH:cytochrome c reductase activity
has exact synonym: NADPH:ferrihemoprotein oxidoreductase activity
has exact synonym: NADPH:hemoprotein oxidoreductase activity
has exact synonym: TPNH2 cytochrome c reductase activity
has exact synonym: cytochrome P-450 reductase activity
has related synonym: CPR activity
has related synonym: FAD-cytochrome c reductase activity
has related synonym: NADP--cytochrome c reductase activity
has related synonym: NADP--cytochrome reductase activity
has related synonym: NADPH--cytochrome P450 oxidoreductase activity
has related synonym: NADPH--cytochrome P450 reductase activity
has related synonym: NADPH--cytochrome c oxidoreductase activity
has related synonym: NADPH--cytochrome c reductase activity
has related synonym: NADPH--ferricytochrome c oxidoreductase activity
has related synonym: NADPH--ferrihemoprotein reductase activity
has related synonym: NADPH-dependent cytochrome c reductase activity
has related synonym: NADPH:P450 reductase activity
has related synonym: POR
has related synonym: TPNH(2) cytochrome c reductase activity
has related synonym: TPNH-cytochrome c reductase activity
has related synonym: aldehyde reductase (NADPH-dependent) activity
has related synonym: cytochrome P450 reductase activity
has related synonym: cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
has related synonym: dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
has related synonym: ferrihemoprotein P-450 reductase activity
has related synonym: reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
has related synonym: reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
type: Class
subclass of: GO_0016653

NADPH dehydrogenase activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.
has exact synonym: NADPH diaphorase activity
has exact synonym: NADPH-dehydrogenase activity
has exact synonym: NADPH2 diaphorase activity
has exact synonym: NADPH2-dehydrogenase activity
has exact synonym: NADPH:(acceptor) oxidoreductase activity
has exact synonym: NADPH:acceptor oxidoreductase activity
has exact synonym: TPNH dehydrogenase activity
has exact synonym: TPNH-diaphorase activity
has exact synonym: dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity
has exact synonym: reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity
has exact synonym: triphosphopyridine diaphorase activity
has exact synonym: triphosphopyridine nucleotide diaphorase activity
has related synonym: OYE
has related synonym: old yellow enzyme
replaces: GO_0008468
replaces: GO_0016660
type: Class
subclass of: GO_0016651

NADPH:quinone reductase activity
IAO_0000115: Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.
has exact synonym: NADPH:quinone oxidoreductase activity
has related synonym: quinone oxidoreductase activity
has related synonym: zeta-crystallin activity
type: Class
subclass of: GO_0016655

O-acetylhomoserine aminocarboxypropyltransferase activity
IAO_0000115: Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers.
has exact synonym: L-methionine anabolism, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine formation, direct, from O-acetyl-L-homoserine
has exact synonym: L-methionine synthesis, direct, from O-acetyl-L-homoserine
has exact synonym: O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity
has exact synonym: O-acetyl-L-homoserine sulfhydrolase activity
has exact synonym: O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity
has exact synonym: O-acetylhomoserine (thiol)-lyase activity
has exact synonym: O-acetylhomoserine sulfhydrolase activity
has exact synonym: OAH sulfhydrylase activity
has exact synonym: methionine biosynthetic process, direct, from O-acetyl-L-homoserine
replaces: GO_0019282
type: Class
subclass of: part-of-parent-71266
subclass of: GO_0016765

cystathionine gamma-synthase activity
IAO_0000115: Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.
has exact synonym: CTT gamma synthase activity
has exact synonym: O-succinyl-L-homoserine (thiol)-lyase activity
has exact synonym: O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity
has exact synonym: O-succinyl-L-homoserine succinate-lyase activity
has exact synonym: O-succinylhomoserine (thiol)-lyase activity
has exact synonym: O-succinylhomoserine synthase activity
has exact synonym: O-succinylhomoserine synthetase activity
has exact synonym: O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity
has exact synonym: cystathionine g-synthase activity
has exact synonym: cystathionine gamma synthase activity
has exact synonym: cystathionine synthase activity
has exact synonym: cystathionine synthetase activity
has related synonym: homoserine O-transsuccinylase activity
has related synonym: homoserine transsuccinylase activity
replaces: GO_0000505
type: Class
subclass of: GO_0016765

RNA-3'-phosphate cyclase activity
IAO_0000115: Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.
has exact synonym: RNA 3'-terminal phosphate cyclase activity
has exact synonym: RNA cyclase activity
has exact synonym: RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)
type: Class
subclass of: GO_0009975
subclass of: GO_0016886
subclass of: GO_0140098

RNA-directed DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
has exact synonym: DNA nucleotidyltransferase (RNA-directed) activity
has exact synonym: RNA revertase activity
has exact synonym: RNA-dependent DNA polymerase activity
has exact synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase activity
has exact synonym: RNA-instructed DNA polymerase activity
has exact synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
has exact synonym: reverse transcriptase activity
has related synonym: RNA-directed DNA polymerase, group II intron encoded
has related synonym: RNA-directed DNA polymerase, transposon encoded
has related synonym: RT
has related synonym: revertase activity
type: Class
subclass of: part-of-parent-6278
subclass of: GO_0034061

obsolete RNA-directed DNA polymerase, transposon encoded
IAO_0000115: OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.
type: Class
subclass of: ObsoleteClass

obsolete RNA-directed DNA polymerase, group II intron encoded
IAO_0000115: OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.
type: Class
subclass of: ObsoleteClass

RNA-directed 5'-3' RNA polymerase activity
IAO_0000115: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
has exact synonym: 3D polymerase activity
has exact synonym: Q-beta replicase activity
has exact synonym: RNA nucleotidyltransferase (RNA-directed) activity
has exact synonym: RNA replicase activity
has exact synonym: RNA-dependent RNA polymerase activity
has exact synonym: RNA-dependent RNA replicase activity
has exact synonym: RNA-dependent ribonucleate nucleotidyltransferase activity
has exact synonym: nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
has exact synonym: ribonucleic acid replicase activity
has exact synonym: ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity
has exact synonym: ribonucleic acid-dependent ribonucleic acid polymerase activity
has exact synonym: ribonucleic replicase activity
has related synonym: PB1 proteins
has related synonym: PB2 proteins
has related synonym: RDRP
has related synonym: RNA synthetase activity
has related synonym: RNA-directed RNA polymerase activity
has related synonym: phage f2 replicase
has related synonym: polymerase L
has related synonym: ribonucleic synthetase activity
has related synonym: transcriptase
type: Class
subclass of: part-of-parent-1172
subclass of: GO_0034062

obsolete RNA editase activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

RNA ligase (ATP) activity
IAO_0000115: Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).
has exact synonym: poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)
has exact synonym: polyribonucleotide ligase activity
has exact synonym: polyribonucleotide synthase (ATP) activity
has related synonym: ribonucleic ligase activity
type: Class
subclass of: GO_0008452

(S)-2-hydroxy-acid oxidase activity
IAO_0000115: Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.
has exact synonym: (S)-2-hydroxy-acid:oxygen 2-oxidoreductase
has exact synonym: L-2-hydroxy acid oxidase
has exact synonym: L-alpha-hydroxy acid oxidase
has exact synonym: oxidase, L-2-hydroxy acid
has related synonym: hydroxy-acid oxidase A activity
has related synonym: hydroxy-acid oxidase B activity
has related synonym: hydroxyacid oxidase A
type: Class
subclass of: GO_0016899

UDP-N-acetylglucosamine 4-epimerase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.
has exact synonym: UDP acetylglucosamine epimerase activity
has exact synonym: UDP-GlcNAc 4-epimerase activity
has exact synonym: UDP-N-acetyl-D-glucosamine 4-epimerase activity
has exact synonym: uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity
has exact synonym: uridine diphosphate N-acetylglucosamine-4-epimerase activity
has exact synonym: uridine diphosphoacetylglucosamine epimerase activity
type: Class
subclass of: GO_0016857

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
has exact synonym: GlcNAc-1-P transferase activity
has exact synonym: N-acetylglucosamine-1-phosphate transferase activity
has exact synonym: UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity
has exact synonym: UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity
has exact synonym: UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity
has exact synonym: UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity
has exact synonym: chitobiosylpyrophosphoryldolichol synthase activity
has exact synonym: dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity
type: Class
subclass of: GO_0016780

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.
has exact synonym: N-acetylglucosaminyl phosphotransferase activity
has exact synonym: UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity
has exact synonym: UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity
has exact synonym: lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity
has related synonym: N-acetylglucosaminylphosphotransferase activity
type: Class
subclass of: GO_0016780

UDP-N-acetylglucosamine diphosphorylase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.
has exact synonym: GlmU uridylyltransferase activity
has exact synonym: N-acetylglucosamine-1-phosphate uridyltransferase activity
has exact synonym: UDP-GlcNAc pyrophosphorylase activity
has exact synonym: UDP-N-acetylglucosamine pyrophosphorylase activity
has exact synonym: UDP-acetylglucosamine pyrophosphorylase activity
has exact synonym: UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity
has exact synonym: UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity
has exact synonym: uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity
has exact synonym: uridine diphosphoacetylglucosamine phosphorylase activity
has exact synonym: uridine diphosphoacetylglucosamine pyrophosphorylase activity
has related synonym: acetylglucosamine 1-phosphate uridylyltransferase
type: Class
subclass of: GO_0070569

UDP-glucose 4-epimerase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose = UDP-galactose.
has exact synonym: 4-epimerase activity
has exact synonym: UDP-D-galactose 4-epimerase activity
has exact synonym: UDP-galactose 4-epimerase activity
has exact synonym: UDP-glucose epimerase activity
has exact synonym: UDPG-4-epimerase activity
has exact synonym: UDPgalactose 4-epimerase activity
has exact synonym: UDPglucose 4-epimerase activity
has exact synonym: uridine diphosphate galactose 4-epimerase activity
has exact synonym: uridine diphosphate glucose 4-epimerase activity
has exact synonym: uridine diphospho-galactose-4-epimerase activity
has exact synonym: uridine diphosphoglucose 4-epimerase activity
has exact synonym: uridine diphosphoglucose epimerase activity
has related synonym: galactowaldenase activity
type: Class
subclass of: GO_0016857

UDP-glucose 6-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.
type: Class
subclass of: GO_0016616

UDP-glucose:glycoprotein glucosyltransferase activity
IAO_0000115: Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.
has exact synonym: UGGT activity
type: Class
subclass of: part-of-parent-97359
subclass of: GO_0035251

UTP:glucose-1-phosphate uridylyltransferase activity
IAO_0000115: Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.
has exact synonym: UDP glucose pyrophosphorylase activity
has exact synonym: UDP-glucose diphosphorylase activity
has exact synonym: UDP-glucose pyrophosphorylase activity
has exact synonym: UDPG phosphorylase activity
has exact synonym: UDPG pyrophosphorylase activity
has exact synonym: UTP-glucose-1-phosphate uridylyltransferase activity
has exact synonym: UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity
has exact synonym: glucose-1-phosphate uridylyltransferase activity
has exact synonym: uridine 5'-diphosphoglucose pyrophosphorylase activity
has exact synonym: uridine diphosphate-D-glucose pyrophosphorylase activity
has exact synonym: uridine diphosphoglucose pyrophosphorylase activity
has exact synonym: uridine-diphosphate glucose pyrophosphorylase activity
type: Class
subclass of: GO_0051748

acetolactate synthase activity
IAO_0000115: Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
has exact synonym: acetohydroxy acid synthetase activity
has exact synonym: acetohydroxyacid synthase activity
has exact synonym: acetolactate pyruvate-lyase (carboxylating) activity
has exact synonym: acetolactic synthetase activity
has exact synonym: alpha-acetohydroxy acid synthetase activity
has exact synonym: alpha-acetohydroxyacid synthase activity
has exact synonym: alpha-acetolactate synthase activity
has exact synonym: alpha-acetolactate synthetase activity
has exact synonym: pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
type: Class
subclass of: GO_0016744

acetyl-CoA C-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
has exact synonym: 3-oxothiolase activity
has exact synonym: acetoacetyl-CoA thiolase activity
has exact synonym: acetyl coenzyme A thiolase activity
has exact synonym: acetyl-CoA acetyltransferase activity
has exact synonym: acetyl-CoA:N-acetyltransferase activity
has exact synonym: acetyl-CoA:acetyl-CoA C-acetyltransferase activity
has exact synonym: beta-acetoacetyl coenzyme A thiolase activity
has related synonym: 2-methylacetoacetyl-CoA thiolase
has related synonym: thiolase II
type: Class
subclass of: acetyl-CoA C-acyltransferase activity
subclass of: GO_0016453

acetyl-CoA hydrolase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
has exact synonym: acetyl coenzyme A acylase activity
has exact synonym: acetyl coenzyme A deacylase activity
has exact synonym: acetyl coenzyme A hydrolase activity
has exact synonym: acetyl-CoA acylase activity
has exact synonym: acetyl-CoA deacylase activity
has exact synonym: acetyl-CoA thiol esterase activity
type: Class
subclass of: GO_0016289

acetate-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
has exact synonym: acetate:CoA ligase (AMP-forming)
has exact synonym: acetic thiokinase activity
has exact synonym: acetyl CoA ligase activity
has exact synonym: acetyl CoA synthase activity
has exact synonym: acetyl coenzyme A synthetase activity
has exact synonym: acetyl-CoA synthase activity
has exact synonym: acetyl-CoA synthetase activity
has exact synonym: acetyl-activating enzyme activity
has exact synonym: acetyl-coenzyme A synthase activity
has exact synonym: short chain fatty acyl-CoA synthetase activity
has exact synonym: short-chain acyl-coenzyme A synthetase activity
has related synonym: ACS
has related synonym: acetate thiokinase activity
has related synonym: acetate to acetyl-CoA
has related synonym: acetyl activating enzyme
has related synonym: acyl-activating enzyme activity
type: Class
subclass of: GO_0016405
subclass of: GO_0016878

acetyl-CoA C-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
has exact synonym: 2-keto-acyl thiolase activity
has exact synonym: 3-ketoacyl CoA thiolase activity
has exact synonym: 3-ketoacyl coenzyme A thiolase activity
has exact synonym: 3-ketoacyl thiolase activity
has exact synonym: 3-ketoacyl-CoA thiolase activity
has exact synonym: 3-ketothiolase activity
has exact synonym: 3-oxoacyl-CoA thiolase activity
has exact synonym: 3-oxoacyl-coenzyme A thiolase activity
has exact synonym: 6-oxoacyl-CoA thiolase activity
has exact synonym: acetoacetyl-CoA beta-ketothiolase activity
has exact synonym: acetyl-CoA acyltransferase activity
has exact synonym: acyl-CoA:acetyl-CoA C-acyltransferase activity
has exact synonym: beta-ketoacyl coenzyme A thiolase activity
has exact synonym: beta-ketoadipyl coenzyme A thiolase activity
has exact synonym: beta-ketothiolase activity
has exact synonym: ketoacyl-CoA acyltransferase activity
has exact synonym: ketoacyl-coenzyme A thiolase activity
has exact synonym: long-chain 3-oxoacyl-CoA thiolase activity
has exact synonym: oxoacyl-coenzyme A thiolase activity
has exact synonym: pro-3-ketoacyl-CoA thiolase activity
has related synonym: 2-methylacetoacetyl-CoA thiolase
has related synonym: KAT
has related synonym: beta-ketoacyl-CoA thiolase activity
has related synonym: beta-ketoadipyl-CoA thiolase activity
has related synonym: thiolase I
type: Class
subclass of: GO_0016408

acetyl-CoA carboxylase activity
IAO_0000115: Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
has exact synonym: acetyl coenzyme A carboxylase activity
has exact synonym: acetyl-CoA:carbon-dioxide ligase (ADP-forming)
type: Class
subclass of: GO_0016421

acetylcholinesterase activity
IAO_0000115: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.
has exact synonym: acetyl.beta-methylcholinesterase activity
has exact synonym: acetylcholine acetylhydrolase activity
has exact synonym: acetylcholine hydrolase activity
has exact synonym: acetylthiocholinesterase activity
has exact synonym: choline esterase I activity
has exact synonym: true cholinesterase activity
has related synonym: AcCholE
type: Class
subclass of: cholinesterase activity

acetylglutamate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate.
has exact synonym: ATP:N-acetyl-L-glutamate 5-phosphotransferase activity
has exact synonym: N-acetylglutamate 5-phosphotransferase activity
has exact synonym: N-acetylglutamate kinase activity
has exact synonym: N-acetylglutamate phosphokinase activity
has exact synonym: N-acetylglutamic 5-phosphotransferase activity
has exact synonym: acetylglutamate phosphokinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016774

N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
has exact synonym: 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
has exact synonym: ACOAT activity
has exact synonym: N(2)-acetylornithine 5-transaminase activity
has exact synonym: N-acetylornithine aminotransferase activity
has exact synonym: N-acetylornithine-delta-transaminase activity
has exact synonym: N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity
has exact synonym: N2-acetylornithine 5-aminotransferase activity
has exact synonym: N2-acetylornithine 5-transaminase activity
has exact synonym: acetylornithine 5-aminotransferase activity
has exact synonym: acetylornithine delta-transaminase activity
has related synonym: acetylornithine aminotransferase activity
has related synonym: acetylornithine transaminase activity
has related synonym: succinylornithine aminotransferase activity
replaces: GO_0047318
type: Class
subclass of: GO_0008483

acid phosphatase activity
IAO_0000115: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
has exact synonym: acid monophosphatase activity
has exact synonym: acid nucleoside diphosphate phosphatase activity
has exact synonym: acid phosphohydrolase activity
has exact synonym: acid phosphomonoester hydrolase activity
has exact synonym: acid phosphomonoesterase activity
has exact synonym: orthophosphoric-monoester phosphohydrolase (acid optimum)
has exact synonym: phosphate-monoester phosphohydrolase (acid optimum)
has related synonym: glycerophosphatase activity
has related synonym: phosphomonoesterase activity
has related synonym: uteroferrin
type: Class
subclass of: GO_0016791

aconitate hydratase activity
IAO_0000115: Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
has exact synonym: aconitase activity
has exact synonym: cis-aconitase activity
has exact synonym: citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
has exact synonym: citrate(isocitrate) hydro-lyase activity
has related synonym: citrate hydro-lyase activity
type: Class
subclass of: GO_0016836

acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
has exact synonym: acyl CoA dehydrogenase activity
has exact synonym: acyl coenzyme A dehydrogenase activity
has exact synonym: acyl dehydrogenase activity
has exact synonym: acyl-CoA reductase activity
has exact synonym: acyl-CoA:(acceptor) 2,3-oxidoreductase activity
has exact synonym: acyl-CoA:acceptor 2,3-oxidoreductase activity
has exact synonym: fatty acyl coenzyme A dehydrogenase activity
has exact synonym: fatty-acyl-CoA dehydrogenase activity
has exact synonym: general acyl CoA dehydrogenase activity
has exact synonym: long-chain acyl coenzyme A dehydrogenase activity
has exact synonym: long-chain acyl-CoA dehydrogenase activity
has exact synonym: medium-chain acyl-coenzyme A dehydrogenase activity
has related synonym: medium-chain acyl-CoA dehydrogenase activity
replaces: GO_0019109
type: Class
subclass of: GO_0016627

acyl-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain carboxylic acids have chain lengths of C13 to C22.
type: Class
subclass of: GO_0016405
subclass of: GO_0016878

acyl-CoA oxidase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
has exact synonym: acyl coenzyme A oxidase activity
has exact synonym: acyl-CoA:oxygen 2-oxidoreductase activity
has exact synonym: fatty acyl-CoA oxidase activity
has exact synonym: fatty acyl-coenzyme A oxidase activity
type: Class
subclass of: GO_0016634

acylphosphatase activity
IAO_0000115: Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
has exact synonym: 1,3-diphosphoglycerate phosphatase activity
has exact synonym: acetic phosphatase activity
has exact synonym: acetylphosphatase activity
has exact synonym: acylphosphate phosphohydrolase activity
has related synonym: GP 1-3
has related synonym: Ho 1-3
type: Class
subclass of: GO_0016818

adenine phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
has exact synonym: AMP diphosphorylase activity
has exact synonym: AMP pyrophosphorylase activity
has exact synonym: AMP-pyrophosphate phosphoribosyltransferase activity
has exact synonym: AMP:diphosphate phospho-D-ribosyltransferase activity
has exact synonym: APRT activity
has exact synonym: adenine phosphoribosylpyrophosphate transferase activity
has exact synonym: adenosine phosphoribosyltransferase activity
has exact synonym: adenylate pyrophosphorylase activity
has exact synonym: adenylic pyrophosphorylase activity
has related synonym: transphosphoribosidase activity
type: Class
subclass of: GO_0106130

adenosine deaminase activity
IAO_0000115: Catalysis of the reaction: adenosine + H2O = inosine + NH3.
has exact synonym: adenosine aminohydrolase activity
has exact synonym: adenosine deaminase reaction
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

adenosine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + adenosine = ADP + AMP.
has exact synonym: ATP:adenosine 5'-phosphotransferase activity
has exact synonym: adenosine 5-phosphotransferase activity
has exact synonym: adenosine kinase (phosphorylating)
type: Class
subclass of: part-of-parent-6167
subclass of: GO_0016773
subclass of: GO_0019206

obsolete plasma membrane cation-transporting ATPase
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete heavy metal-exporting ATPase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete ATP-binding cassette (ABC) transporter activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

adenosylhomocysteinase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
has exact synonym: AdoHcyase activity
has exact synonym: S-adenosyl-L-homocysteine hydrolase activity
has exact synonym: S-adenosylhomocysteinase activity
has exact synonym: S-adenosylhomocysteine synthase activity
has exact synonym: SAHase activity
has exact synonym: adenosylhomocysteine hydrolase activity
has related synonym: S-adenosylhomocysteine hydrolase activity
type: Class
subclass of: GO_0016802

adenosylmethionine decarboxylase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2).
has exact synonym: S-adenosyl-L-methionine carboxy-lyase activity
has exact synonym: S-adenosyl-L-methionine decarboxylase activity
has exact synonym: S-adenosylmethionine decarboxylase activity
has exact synonym: adenosyl methionine decarboxylase activity
has related synonym: S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]
type: Class
subclass of: GO_0016831

adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAO_0000115: Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.
has exact synonym: 7,8-diamino-pelargonic acid aminotransferase activity
has exact synonym: 7,8-diaminonanoate transaminase activity
has exact synonym: 7,8-diaminononanoate aminotransferase activity
has exact synonym: 7,8-diaminononanoate transaminase activity
has exact synonym: 7,8-diaminopelargonic acid aminotransferase activity
has exact synonym: 7-keto-8-aminopelargonic acid aminotransferase activity
has exact synonym: DAPA aminotransferase activity
has exact synonym: DAPA transaminase activity
has exact synonym: S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity
has exact synonym: adenosyl methionine-8-amino-7-oxononanoate transaminase activity
has exact synonym: adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity
has exact synonym: adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity
has exact synonym: diaminopelargonate synthase activity
has related synonym: 7-keto-8-aminopelargonic acid
type: Class
subclass of: GO_0008483

adenylate cyclase activity
IAO_0000115: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
has exact synonym: 3',5'-cyclic AMP synthetase activity
has exact synonym: ATP diphosphate-lyase (cyclizing) activity
has exact synonym: ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity
has exact synonym: ATP pyrophosphate-lyase activity
has exact synonym: adenyl cyclase activity
has exact synonym: adenylyl cyclase activity
has exact synonym: adenylylcyclase activity
has related synonym: cAMP generating peptide activity
type: Class
subclass of: GO_0009975
subclass of: GO_0016849

adenylate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + AMP = 2 ADP.
has exact synonym: 5'-AMP-kinase activity
has exact synonym: ATP:AMP phosphotransferase activity
has exact synonym: adenylic kinase activity
has exact synonym: adenylokinase activity
has related synonym: myokinase activity
type: Class
subclass of: GO_0050145

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
IAO_0000115: Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
has exact synonym: 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity
has exact synonym: N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity
has related synonym: adenylosuccinase activity
has related synonym: adenylosuccinate lyase activity
has related synonym: succino AMP-lyase activity
type: Class
subclass of: GO_0016842

adenylosuccinate synthase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
has exact synonym: IMP--aspartate ligase activity
has exact synonym: IMP:L-aspartate ligase (GDP-forming)
has exact synonym: adenylosuccinate synthetase activity
has exact synonym: succino-AMP synthetase activity
has exact synonym: succinoadenylic kinosynthetase activity
type: Class
subclass of: GO_0016879

adenylylsulfate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.
has exact synonym: 5'-phosphoadenosine sulfate kinase activity
has exact synonym: APS kinase activity
has exact synonym: ATP:adenylyl-sulfate 3'-phosphotransferase activity
has exact synonym: adenosine 5'-phosphosulfate kinase activity
has exact synonym: adenosine phosphosulfate kinase activity
has exact synonym: adenosine phosphosulfokinase activity
has exact synonym: adenosine-5'-phosphosulfate 3'-phosphotransferase activity
has exact synonym: adenosine-5'-phosphosulfate-3'-phosphokinase activity
has exact synonym: adenosine-5'-phosphosulphate 3'-phosphotransferase activity
has exact synonym: adenylyl-sulfate kinase activity
has exact synonym: adenylyl-sulphate kinase activity
has exact synonym: adenylylsulfate kinase (phosphorylating)
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

L-alanine:2-oxoglutarate aminotransferase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
has exact synonym: L-alanine-alpha-ketoglutarate aminotransferase activity
has exact synonym: alanine-alpha-ketoglutarate aminotransferase activity
has exact synonym: alanine-pyruvate aminotransferase activity
has exact synonym: glutamic acid-pyruvic acid transaminase activity
has exact synonym: glutamic--alanine transaminase activity
has exact synonym: glutamic--pyruvic transaminase activity
has exact synonym: glutamic-pyruvic aminotransferase activity
has exact synonym: pyruvate-alanine aminotransferase activity
has exact synonym: pyruvate-glutamate transaminase activity
has related synonym: ALT
has related synonym: GPT
has related synonym: L-alanine aminotransferase activity
has related synonym: L-alanine transaminase activity
has related synonym: alanine aminotransferase activity
has related synonym: alanine transaminase activity
has related synonym: beta-alanine aminotransferase
has related synonym: pyruvate transaminase activity
type: Class
subclass of: GO_0047635

alcohol dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
has exact synonym: NAD-dependent alcohol dehydrogenase
has exact synonym: NAD-specific aromatic alcohol dehydrogenase
has exact synonym: NADH-alcohol dehydrogenase
has exact synonym: NADH-aldehyde dehydrogenase
has exact synonym: alcohol:NAD+ oxidoreductase
has exact synonym: aldo-keto reductase (NAD) activity
has related synonym: ADH
has related synonym: alcohol dehydrogenase activity
has related synonym: aldehyde dehydrogenase (NAD) activity
has related synonym: aliphatic alcohol dehydrogenase
has related synonym: ethanol dehydrogenase
has related synonym: primary alcohol dehydrogenase
has related synonym: yeast alcohol dehydrogenase
type: Class
subclass of: GO_0018455

alcohol dehydrogenase activity, metal ion-independent
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion.
type: Class
subclass of: alcohol dehydrogenase (NAD+) activity

alcohol dehydrogenase activity, zinc-dependent
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.
type: Class
subclass of: alcohol dehydrogenase (NAD+) activity

alcohol dehydrogenase activity, iron-dependent
IAO_0000115: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron.
type: Class
subclass of: alcohol dehydrogenase (NAD+) activity

alcohol O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.
has exact synonym: AATASE activity
has exact synonym: acetyl-CoA:alcohol O-acetyltransferase activity
has exact synonym: alcohol acetyltransferase activity
type: Class
subclass of: GO_0016413
subclass of: GO_0034318

alcohol sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
has exact synonym: 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity
has exact synonym: 3-hydroxysteroid sulfotransferase activity
has exact synonym: 3beta-hydroxy steroid sulfotransferase activity
has exact synonym: 3beta-hydroxysteroid sulfotransferase activity
has exact synonym: 5alpha-androstenol sulfotransferase activity
has exact synonym: alcohol sulphotransferase activity
has exact synonym: alcohol/hydroxysteroid sulfotransferase activity
has exact synonym: dehydroepiandrosterone sulfotransferase activity
has exact synonym: delta5-3beta-hydroxysteroid sulfokinase activity
has exact synonym: estrogen sulfokinase activity
has exact synonym: hydroxysteroid sulfotransferase activity
has exact synonym: steroid sulfokinase activity
has exact synonym: sterol sulfokinase activity
has exact synonym: sterol sulfotransferase activity
has related synonym: HST
has related synonym: estrogen sulfotransferase
has related synonym: steroid alcohol sulfotransferase
type: Class
subclass of: GO_0008146

3-chloroallyl aldehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
type: Class
subclass of: GO_0016620

aldehyde dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
has exact synonym: CoA-independent aldehyde dehydrogenase activity
has exact synonym: NAD-aldehyde dehydrogenase activity
has exact synonym: NAD-dependent 4-hydroxynonenal dehydrogenase activity
has exact synonym: NAD-dependent aldehyde dehydrogenase activity
has exact synonym: NAD-linked aldehyde dehydrogenase activity
has exact synonym: aldehyde dehydrogenase (NAD+)
has exact synonym: aldehyde:NAD+ oxidoreductase activity
has exact synonym: m-methylbenzaldehyde dehydrogenase activity
has exact synonym: propionaldehyde dehydrogenase activity
type: Class
subclass of: aldehyde dehydrogenase [NAD(P)+] activity

aldehyde dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
has exact synonym: aldehyde:NAD(P)+ oxidoreductase activity
has related synonym: ALDH
type: Class
subclass of: GO_0016620

aldehyde oxidase activity
IAO_0000115: Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
has exact synonym: aldehyde:oxygen oxidoreductase activity
has related synonym: quinoline oxidase activity
type: Class
subclass of: GO_0016623

alditol:NADP+ 1-oxidoreductase activity
IAO_0000115: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
has exact synonym: aldehyde reductase activity
has exact synonym: aldose reductase activity
has related synonym: polyol dehydrogenase (NADP(+)) activity
type: Class
subclass of: GO_0008106

aldo-keto reductase (NADP) activity
IAO_0000115: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
has exact synonym: NADPH-dependent aldo-keto reductase activity
has exact synonym: aldo-keto reductase (NADP+) activity
has exact synonym: aldo-keto reductase activity
has related synonym: alcohol dehydrogenase (NADP+) activity
type: Class
subclass of: GO_0016616

aldose 1-epimerase activity
IAO_0000115: Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose.
has related synonym: aldose mutarotase activity
has related synonym: mutarotase activity
type: Class
subclass of: GO_0016857

alkaline phosphatase activity
IAO_0000115: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
has exact synonym: alkaline phenyl phosphatase activity
has exact synonym: alkaline phosphohydrolase activity
has exact synonym: alkaline phosphomonoesterase activity
has exact synonym: orthophosphoric-monoester phosphohydrolase (alkaline optimum)
has exact synonym: phosphate-monoester phosphohydrolase (alkaline optimum)
has related synonym: glycerophosphatase activity
has related synonym: phosphomonoesterase activity
type: Class
subclass of: GO_0016791

allantoicase activity
IAO_0000115: Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea.
has exact synonym: allantoate amidinohydrolase activity
has exact synonym: allantoine amidinohydrolase activity
type: Class
subclass of: GO_0016813

allantoinase activity
IAO_0000115: Catalysis of the reaction: allantoin + H2O = allantoate.
has exact synonym: (S)-allantoin amidohydrolase activity
type: Class
subclass of: GO_0016812

allophanate hydrolase activity
IAO_0000115: Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+).
has exact synonym: allophanate lyase activity
has exact synonym: urea-1-carboxylate amidohydrolase activity
type: Class
subclass of: GO_0016811

amidase activity
IAO_0000115: Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.
has exact synonym: N-acetylaminohydrolase activity
has exact synonym: acetamidase activity
has exact synonym: acylamidase activity
has exact synonym: acylamide amidohydrolase activity
has exact synonym: acylase activity
has exact synonym: amidohydrolase activity
has exact synonym: fatty acylamidase activity
type: Class
subclass of: GO_0016811

acetyl-CoA:L-glutamate N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+).
has exact synonym: acetylglutamate acetylglutamate synthetase activity
has exact synonym: amino acid acetyltransferase activity
has related synonym: AGAS
has related synonym: N-acetylglutamate synthase activity
has related synonym: amino-acid N-acetyltransferase activity
type: Class
subclass of: GO_0008080

L-aminoadipate-semialdehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
has exact synonym: 2-aminoadipate semialdehyde dehydrogenase activity
has exact synonym: 2-aminoadipic semialdehyde dehydrogenase activity
has exact synonym: AAR
has exact synonym: L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
has exact synonym: L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
has exact synonym: L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
has exact synonym: L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
has exact synonym: alpha-aminoadipate reductase activity
has exact synonym: alpha-aminoadipate-semialdehyde dehydrogenase activity
has exact synonym: aminoadipate semialdehyde dehydrogenase activity
has exact synonym: aminoadipate-semialdehyde dehydrogenase activity
type: Class
subclass of: GO_0016620

amidophosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.
has exact synonym: 5'-phosphoribosylpyrophosphate amidotransferase activity
has exact synonym: 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
has exact synonym: 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
has exact synonym: 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
has exact synonym: alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
has exact synonym: glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
has exact synonym: glutamine phosphoribosyldiphosphate amidotransferase activity
has exact synonym: glutamine phosphoribosylpyrophosphate amidotransferase activity
has exact synonym: glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
has exact synonym: phosphoribose pyrophosphate amidotransferase activity
has exact synonym: phosphoribosyl pyrophosphate amidotransferase activity
has exact synonym: phosphoribosyldiphosphate 5-amidotransferase activity
has exact synonym: phosphoribosylpyrophosphate glutamyl amidotransferase activity
type: Class
subclass of: GO_0016763

aminoacyl-tRNA hydrolase activity
IAO_0000115: Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
has exact synonym: N-substituted aminoacyl transfer RNA hydrolase activity
has exact synonym: aminoacyl-tRNA aminoacylhydrolase activity
has exact synonym: aminoacyl-tRNA hydrolase reaction
has exact synonym: aminoacyl-transfer ribonucleate hydrolase activity
has exact synonym: peptidyl-tRNA hydrolase activity
has related synonym: D-tyrosyl-tRNA hydrolase activity
replaces: GO_0019850
replaces: GO_0019851
type: Class
subclass of: GO_0052689
subclass of: GO_0140101

aminoacylase activity
IAO_0000115: Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.
has exact synonym: L-amino-acid acylase activity
has exact synonym: L-aminoacylase activity
has exact synonym: N-acyl-L-amino-acid amidohydrolase activity
has exact synonym: alpha-N-acylaminoacid hydrolase activity
has exact synonym: amido acid deacylase activity
has exact synonym: hippurase activity
has exact synonym: long acyl amidoacylase activity
has exact synonym: short acyl amidoacylase activity
has related synonym: acylase I activity
has related synonym: aminoacylase I activity
has related synonym: benzamidase activity
has related synonym: dehydropeptidase II activity
has related synonym: histozyme activity
type: Class
subclass of: GO_0016811

aminomethyltransferase activity
IAO_0000115: Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
has exact synonym: S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has exact synonym: protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has exact synonym: protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity
has exact synonym: tetrahydrofolate aminomethyltransferase activity
has related synonym: T-protein
has related synonym: glycine synthase activity
has related synonym: glycine-cleavage system T-protein activity
type: Class
subclass of: GO_0008168

anthranilate phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.
has exact synonym: N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity
has exact synonym: anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity
has exact synonym: anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity
has exact synonym: anthranilate-PP-ribose-P phosphoribosyltransferase activity
has exact synonym: phosphoribosyl-anthranilate diphosphorylase activity
has exact synonym: phosphoribosyl-anthranilate pyrophosphorylase activity
has exact synonym: phosphoribosylanthranilate pyrophosphorylase activity
has exact synonym: phosphoribosylanthranilate transferase activity
has related synonym: PRT
type: Class
subclass of: GO_0016763

anthranilate synthase activity
IAO_0000115: Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
has exact synonym: anthranilate synthetase activity
has exact synonym: chorismate pyruvate-lyase (amino-accepting) activity
type: Class
subclass of: GO_0016833

obsolete apyrase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate.
type: Class
subclass of: ObsoleteClass

arachidonate 5-lipoxygenase activity
IAO_0000115: Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.
has exact synonym: 5-delta-lipoxygenase activity
has exact synonym: 5-lipoxygenase activity
has exact synonym: 5Delta-lipoxygenase activity
has exact synonym: arachidonate:oxygen 5-oxidoreductase activity
has exact synonym: arachidonic 5-lipoxygenase activity
has exact synonym: arachidonic acid 5-lipoxygenase activity
has exact synonym: delta5-lipoxygenase activity
has exact synonym: leukotriene-A4 synthase activity
has related synonym: C-5-lipoxygenase activity
has related synonym: LTA synthase activity
has related synonym: delta(5)-lipoxygenase activity
has related synonym: leukotriene A4 synthase
has related synonym: leukotriene-A(4) synthase activity
type: Class
subclass of: GO_0016702

arachidonate 12(S)-lipoxygenase activity
IAO_0000115: Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
has exact synonym: 12Delta-lipoxygenase activity
has exact synonym: 12S-lipoxygenase activity
has exact synonym: C-12 lipoxygenase activity
has exact synonym: LTA4 synthase activity
has exact synonym: arachidonate:oxygen 12-oxidoreductase activity
has exact synonym: delta12-lipoxygenase activity
has related synonym: 12-lipoxygenase activity
has related synonym: leukotriene A4 synthase
type: Class
subclass of: GO_0016702

arginase activity
IAO_0000115: Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
has exact synonym: L-arginase activity
has exact synonym: L-arginine amidinohydrolase activity
has exact synonym: arginine amidinase activity
has exact synonym: arginine transamidinase activity
has exact synonym: canavanase activity
type: Class
subclass of: GO_0016813

arginine kinase activity
IAO_0000115: Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+).
has exact synonym: ATP:L-arginine N-phosphotransferase activity
has exact synonym: adenosine 5'-triphosphate-arginine phosphotransferase activity
has exact synonym: arginine phosphokinase activity
has related synonym: adenosine 5'-triphosphate:L-arginine
type: Class
subclass of: GO_0016775
subclass of: GO_0019202

argininosuccinate synthase activity
IAO_0000115: Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
has exact synonym: L-citrulline:L-aspartate ligase (AMP-forming)
has exact synonym: arginine succinate synthetase activity
has exact synonym: argininosuccinate synthetase activity
has exact synonym: argininosuccinic acid synthetase activity
has exact synonym: arginosuccinate synthetase activity
has exact synonym: citrulline--aspartate ligase activity
type: Class
subclass of: GO_0016879

argininosuccinate lyase activity
IAO_0000115: Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.
has exact synonym: 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
has exact synonym: 2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)
has exact synonym: N-(L-argininosuccinate) arginine-lyase activity
has exact synonym: arginine-succinate lyase activity
has exact synonym: argininosuccinic acid lyase activity
has exact synonym: arginosuccinase activity
has exact synonym: omega-N-(L-arginino)succinate arginine-lyase activity
type: Class
subclass of: GO_0016842

arginyltransferase activity
IAO_0000115: Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.
has exact synonym: L-arginyl-tRNA:protein arginyltransferase activity
has exact synonym: arginine transferase activity
has exact synonym: arginyl-tRNA protein transferase activity
has exact synonym: arginyl-tRNA--protein transferase activity
has exact synonym: arginyl-tRNA-protein transferase activity
has exact synonym: arginyl-transfer ribonucleate-protein aminoacyltransferase activity
has exact synonym: arginyl-transfer ribonucleate-protein transferase activity
replaces: GO_0042172
type: Class
subclass of: part-of-parent-16598
subclass of: GO_0016755

aromatic-L-amino-acid decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.
has exact synonym: aromatic amino acid decarboxylase activity
has exact synonym: aromatic-L-amino-acid carboxy-lyase activity
has related synonym: 5-hydroxytryptophan decarboxylase activity
has related synonym: DOPA decarboxylase activity
has related synonym: L-DOPA decarboxylase activity
has related synonym: aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
has related synonym: hydroxytryptophan decarboxylase activity
has related synonym: tryptophan decarboxylase activity
replaces: GO_0016400
type: Class
subclass of: GO_0016831

aralkylamine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.
has exact synonym: AANAT activity
has exact synonym: acetyl-CoA:2-arylethylamine N-acetyltransferase activity
has exact synonym: arylalkylamine N-acetyltransferase activity
has related synonym: melatonin rhythm enzyme activity
has related synonym: serotonin N-acetyltransferase activity
has related synonym: serotonin acetylase activity
has related synonym: serotonin acetyltransferase activity
type: Class
subclass of: GO_0008080

arylamine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
has exact synonym: 2-naphthylamine N-acetyltransferase activity
has exact synonym: 4-aminobiphenyl N-acetyltransferase activity
has exact synonym: acetyl CoA-arylamine N-acetyltransferase activity
has exact synonym: acetyl-CoA:arylamine N-acetyltransferase activity
has exact synonym: arylamine acetylase activity
has exact synonym: arylamine acetyltransferase activity
has exact synonym: beta-naphthylamine N-acetyltransferase activity
has exact synonym: indoleamine N-acetyltransferase activity
has exact synonym: p-aminosalicylate N-acetyltransferase activity
type: Class
subclass of: GO_0008080

arylformamidase activity
IAO_0000115: Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
has exact synonym: aryl-formylamine amidohydrolase activity
has exact synonym: formylase activity
has exact synonym: formylkynureninase activity
has exact synonym: formylkynurenine formamidase activity
has exact synonym: kynurenine formamidase activity
has related synonym: formamidase I
has related synonym: formamidase II
type: Class
subclass of: GO_0016811

aryl sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
has exact synonym: 1-naphthol phenol sulfotransferase activity
has exact synonym: 2-naphtholsulfotransferase activity
has exact synonym: 3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity
has exact synonym: 4-nitrocatechol sulfokinase activity
has exact synonym: aryl sulphotransferase activity
has exact synonym: dopamine sulfotransferase activity
has exact synonym: p-nitrophenol sulfotransferase activity
has exact synonym: phenol sulfokinase activity
has exact synonym: phenol sulfotransferase activity
has exact synonym: ritodrine sulfotransferase activity
has related synonym: PST
has related synonym: arylsulfotransferase
has related synonym: sulfokinase activity
type: Class
subclass of: GO_0008146

aryldialkylphosphatase activity
IAO_0000115: Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
has exact synonym: aryltriphosphatase activity
has exact synonym: aryltriphosphate dialkylphosphohydrolase activity
has related synonym: A-esterase activity
has related synonym: OPH
has related synonym: esterase B1
has related synonym: esterase E4
has related synonym: organophosphate esterase activity
has related synonym: organophosphate hydrolase activity
has related synonym: organophosphorus acid anhydrase activity
has related synonym: organophosphorus hydrolase activity
has related synonym: paraoxon esterase activity
has related synonym: paraoxon hydrolase activity
has related synonym: paraoxonase activity
has related synonym: phosphotriesterase activity
has related synonym: pirimiphos-methyloxon esterase activity
type: Class
subclass of: GO_0016791

arylesterase activity
IAO_0000115: Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.
has related synonym: A-esterase activity
has related synonym: aromatic esterase
has related synonym: aryl-ester hydrolase
has related synonym: paraoxonase activity
type: Class
subclass of: GO_0052689

arylsulfatase activity
IAO_0000115: Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.
has exact synonym: 4-methylumbelliferyl sulfatase activity
has exact synonym: aryl-sulfate sulfohydrolase activity
has exact synonym: aryl-sulfate sulphohydrolase activity
has exact synonym: aryl-sulphate sulphohydrolase activity
has exact synonym: arylsulfohydrolase activity
has exact synonym: arylsulphatase activity
has exact synonym: estrogen sulfatase activity
has exact synonym: nitrocatechol sulfatase activity
has exact synonym: p-nitrophenyl sulfatase activity
has exact synonym: phenolsulfatase activity
has exact synonym: phenylsulfatase activity
has related synonym: sulfatase activity
type: Class
subclass of: GO_0008484

asparagine synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
has exact synonym: AS-B activity
has exact synonym: L-aspartate:L-glutamine amido-ligase (AMP-forming)
has exact synonym: asparagine synthase (glutamine-hydrolysing)
has exact synonym: asparagine synthetase (glutamine-hydrolysing)
has exact synonym: asparagine synthetase (glutamine-hydrolyzing) activity
has exact synonym: asparagine synthetase B activity
has exact synonym: glutamine-dependent asparagine synthetase activity
has related synonym: AS
type: Class
subclass of: GO_0016884

asparaginase activity
IAO_0000115: Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
has exact synonym: L-asparaginase activity
has exact synonym: L-asparagine amidohydrolase activity
has exact synonym: alpha-asparaginase activity
has exact synonym: colaspase activity
has exact synonym: leunase activity
has related synonym: asparaginase II
has related synonym: crasnitin
has related synonym: elspar
type: Class
subclass of: GO_0016811

aspartate 1-decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-aspartate = beta-alanine + CO2.
has exact synonym: L-aspartate 1-carboxy-lyase (beta-alanine-forming)
has exact synonym: L-aspartate 1-carboxy-lyase activity
has exact synonym: L-aspartate alpha-decarboxylase activity
has exact synonym: aspartate alpha-decarboxylase activity
has related synonym: aspartic alpha-decarboxylase
type: Class
subclass of: GO_0016831

L-aspartate:2-oxoglutarate aminotransferase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
has exact synonym: 2-oxoglutarate-glutamate aminotransferase activity
has exact synonym: L-aspartate-2-ketoglutarate aminotransferase activity
has exact synonym: L-aspartate-2-oxoglutarate aminotransferase activity
has exact synonym: L-aspartate-2-oxoglutarate-transaminase activity
has exact synonym: L-aspartate-alpha-ketoglutarate transaminase activity
has exact synonym: aspartate alpha-ketoglutarate transaminase activity
has exact synonym: aspartate-2-oxoglutarate transaminase activity
has exact synonym: aspartate:2-oxoglutarate aminotransferase activity
has exact synonym: glutamate oxaloacetate transaminase activity
has exact synonym: glutamate-oxalacetate aminotransferase activity
has exact synonym: glutamate-oxalate transaminase activity
has exact synonym: glutamic oxalic transaminase activity
has exact synonym: glutamic--aspartic transaminase activity
has exact synonym: glutamic--oxaloacetic transaminase activity
has exact synonym: glutamic-aspartic aminotransferase activity
has exact synonym: glutamic-oxalacetic transaminase activity
has exact synonym: oxaloacetate transferase activity
has exact synonym: oxaloacetate-aspartate aminotransferase activity
has related synonym: AAT
has related synonym: AspT
has related synonym: GOT (enzyme)
has related synonym: L-aspartate transaminase activity
has related synonym: L-aspartic aminotransferase activity
has related synonym: aspartate aminotransferase activity
has related synonym: aspartate transaminase activity
has related synonym: aspartic acid aminotransferase activity
has related synonym: aspartic aminotransferase activity
has related synonym: aspartyl aminotransferase activity
has related synonym: transaminase A activity
type: Class
subclass of: GO_0008483

aspartate carbamoyltransferase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
has exact synonym: ATCase activity
has exact synonym: L-aspartate transcarbamoylase activity
has exact synonym: L-aspartate transcarbamylase activity
has exact synonym: aspartate carbamyltransferase activity
has exact synonym: aspartate transcarbamoylase activity
has exact synonym: aspartate transcarbamylase activity
has exact synonym: aspartic acid transcarbamoylase activity
has exact synonym: aspartic carbamyltransferase activity
has exact synonym: aspartic transcarbamylase activity
has exact synonym: carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
has exact synonym: carbamoylaspartotranskinase activity
has exact synonym: carbamylaspartotranskinase activity
type: Class
subclass of: GO_0016743

aspartate-ammonia ligase activity
IAO_0000115: Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.
has exact synonym: L-asparagine synthetase activity
has exact synonym: L-aspartate:ammonia ligase (AMP-forming)
has exact synonym: asparagine synthetase activity
type: Class
subclass of: GO_0016211

aspartate kinase activity
IAO_0000115: Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+).
has exact synonym: ATP:L-aspartate 4-phosphotransferase activity
has exact synonym: aspartic kinase activity
has exact synonym: aspartokinase activity
has exact synonym: beta-aspartokinase activity
type: Class
subclass of: GO_0016774
subclass of: GO_0019202

aspartate-semialdehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH.
has exact synonym: ASA dehydrogenase activity
has exact synonym: L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
has exact synonym: L-aspartate-beta-semialdehyde dehydrogenase activity
has exact synonym: L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)
has exact synonym: aspartate semialdehyde dehydrogenase activity
has exact synonym: aspartic beta-semialdehyde dehydrogenase activity
has exact synonym: aspartic semialdehyde dehydrogenase activity
type: Class
subclass of: GO_0016620

biliverdin reductase (NAD(P)+) activity
IAO_0000115: Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.
has exact synonym: bilirubin:NAD(P)+ oxidoreductase activity
type: Class
subclass of: GO_0016628

biotin carboxylase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.
has exact synonym: biotin carboxylase (component of acetyl CoA carboxylase) activity
has exact synonym: biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity
type: Class
subclass of: GO_0016879

biotin synthase activity
IAO_0000115: Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
has exact synonym: biotin synthetase activity
has exact synonym: dethiobiotin:sulfur sulfurtransferase activity
type: Class
subclass of: GO_0016783

biotin-[acetyl-CoA-carboxylase] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).
has exact synonym: acetyl CoA holocarboxylase synthetase activity
has exact synonym: acetyl coenzyme A holocarboxylase synthetase activity
has exact synonym: acetyl-CoA carboxylase biotin holoenzyme synthetase activity
has exact synonym: biotin holoenzyme synthetase activity
has exact synonym: biotin--[acetyl-CoA carboxylase] synthetase activity
has exact synonym: biotin-acetyl coenzyme A carboxylase synthetase activity
has exact synonym: biotin-acetyl-CoA-carboxylase ligase activity
has exact synonym: biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has exact synonym: biotin:apocarboxylase ligase activity
has related synonym: HCS
has related synonym: biotin--protein ligase activity
has related synonym: biotin-acetyl-CoA carboxylase synthetase
type: Class
subclass of: GO_0018271

biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).
has exact synonym: beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity
has exact synonym: biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity
has exact synonym: biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity
has exact synonym: biotin-methylcrotonoyl-CoA-carboxylase ligase activity
has exact synonym: biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has related synonym: biotin-methylcrotonoyl-CoA-carboxylase synthetase
type: Class
subclass of: GO_0018271

biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).
has exact synonym: biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity
has exact synonym: biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity
has exact synonym: biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity
has exact synonym: biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity
has exact synonym: biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity
has exact synonym: biotin-methylmalonyl-CoA-carboxyltransferase ligase activity
has exact synonym: biotin-methylmalonyl-CoA-carboxytransferase ligase activity
has exact synonym: biotin-methylmalonyl-CoA-carboxytransferase synthetase activity
has exact synonym: biotin-transcarboxylase synthetase activity
has exact synonym: biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)
has exact synonym: biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)
has exact synonym: methylmalonyl coenzyme A holotranscarboxylase synthetase activity
has related synonym: biotin-methylmalonyl-CoA-carboxyltransferase synthetase
type: Class
subclass of: GO_0018271

biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
IAO_0000115: Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).
has exact synonym: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity
has exact synonym: biotin-propionyl coenzyme A carboxylase synthetase activity
has exact synonym: biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity
has exact synonym: biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity
has exact synonym: biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)
has exact synonym: holocarboxylase synthetase activity
has exact synonym: propionyl coenzyme A holocarboxylase synthetase activity
has exact synonym: propionyl-CoA holocarboxylase synthetase activity
type: Class
subclass of: GO_0018271

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
IAO_0000115: Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate.
has exact synonym: 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
has exact synonym: P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity
has exact synonym: diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity
has exact synonym: diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity
has exact synonym: diadenosine P1,P4-tetraphosphatase activity
has exact synonym: dinucleoside tetraphosphatase activity
has exact synonym: dinucleosidetetraphosphatase (asymmetrical) activity
has related synonym: Ap(4)A hydrolase activity
has related synonym: Ap(4)Aase activity
has related synonym: Ap4A hydrolase activity
has related synonym: Ap4Aase activity
has related synonym: bis(5'-adenosyl)-tetraphosphatase activity
has related synonym: bis(5'-guanosyl)-tetraphosphatase activity
has related synonym: diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase
has related synonym: diadenosinetetraphosphatase (asymmetrical) activity
has related synonym: diguanosinetetraphosphatase (asymmetrical) activity
type: Class
subclass of: GO_0008796

bisphosphoglycerate mutase activity
IAO_0000115: Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
has exact synonym: 2,3-bisphosphoglycerate mutase activity
has exact synonym: 2,3-bisphosphoglycerate synthase activity
has exact synonym: 2,3-diphosphoglycerate mutase activity
has exact synonym: 2,3-diphosphoglycerate synthase activity
has exact synonym: 2,3-diphosphoglyceromutase activity
has exact synonym: 3-phospho-D-glycerate 1,2-phosphomutase activity
has exact synonym: BPGM activity
has exact synonym: biphosphoglycerate synthase activity
has exact synonym: bisphosphoglycerate synthase activity
has exact synonym: diphosphoglycerate mutase activity
has exact synonym: diphosphoglyceric mutase activity
has exact synonym: diphosphoglyceromutase activity
has exact synonym: glycerate phosphomutase activity
has related synonym: DPGM
has related synonym: bisphosphoglyceromutase
type: Class
subclass of: GO_0016868

bisphosphoglycerate 2-phosphatase activity
IAO_0000115: Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
has related synonym: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity
type: Class
subclass of: GO_0034416

branched-chain-amino-acid transaminase activity
IAO_0000115: Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.
has exact synonym: L-branched chain amino acid aminotransferase activity
has exact synonym: branched-chain amino acid aminotransferase activity
has exact synonym: branched-chain amino acid-glutamate transaminase activity
has exact synonym: branched-chain aminotransferase activity
has exact synonym: branched-chain-amino-acid:2-oxoglutarate aminotransferase activity
has exact synonym: glutamate-branched-chain amino acid transaminase activity
has related synonym: transaminase B activity
type: Class
subclass of: GO_0008483

butyryl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.
has exact synonym: 3-hydroxyacyl CoA reductase activity
has exact synonym: butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity
has exact synonym: butanoyl-CoA:acceptor 2,3-oxidoreductase activity
has exact synonym: butyryl coenzyme A dehydrogenase activity
has exact synonym: butyryl dehydrogenase activity
has exact synonym: enoyl-coenzyme A reductase activity
has exact synonym: ethylene reductase activity
has exact synonym: short-chain acyl CoA dehydrogenase activity
has exact synonym: short-chain acyl-coenzyme A dehydrogenase activity
has exact synonym: unsaturated acyl coenzyme A reductase activity
has related synonym: short-chain-acyl-CoA dehydrogenase activity
has related synonym: unsaturated acyl-CoA reductase activity
type: Class
subclass of: GO_0052890

obsolete carbamoyl-phosphate synthase activity
IAO_0000115: OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate.
type: Class
subclass of: ObsoleteClass

carbamoyl-phosphate synthase (ammonia) activity
IAO_0000115: Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate.
has exact synonym: carbamoyl phosphate synthase (ammonia) activity
has exact synonym: carbamoyl-phosphate synthetase (ammonia) activity
has exact synonym: carbamoyl-phosphate synthetase I activity
has exact synonym: carbamoylphosphate synthase (ammonia)
has exact synonym: carbamoylphosphate synthase activity
has exact synonym: carbamoylphosphate synthetase (ammonia) activity
has exact synonym: carbamylphosphate synthetase activity
has exact synonym: carbmoylphosphate synthetase activity
has exact synonym: carbon-dioxide--ammonia ligase activity
has exact synonym: carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
has related synonym: CPS I activity
has related synonym: carbamylphosphate synthetase I
type: Class
subclass of: GO_0016879

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAO_0000115: Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
has exact synonym: CPS activity
has exact synonym: GD-CPSase activity
has exact synonym: carbamoyl phosphate synthase (glutamine-hydrolyzing) activity
has exact synonym: carbamoyl phosphate synthetase activity
has exact synonym: carbamoyl-phosphate synthase (glutamine-hydrolysing) activity
has exact synonym: carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity
has exact synonym: carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity
has exact synonym: carbamoylphosphate synthetase II activity
has exact synonym: carbamyl phosphate synthetase (glutamine) activity
has exact synonym: carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
has exact synonym: glutamine-dependent carbamoyl-phosphate synthase activity
has exact synonym: glutamine-dependent carbamyl phosphate synthetase activity
has exact synonym: hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity
type: Class
subclass of: GO_0016884

carbonate dehydratase activity
IAO_0000115: Catalysis of the reaction: H2CO3 = CO2 + H2O.
has exact synonym: anhydrase activity
has exact synonym: carbonate anhydrase activity
has exact synonym: carbonate hydro-lyase (carbon-dioxide-forming)
has exact synonym: carbonate hydro-lyase activity
has exact synonym: carbonic acid anhydrase activity
has exact synonym: carbonic anhydrase activity
has exact synonym: carbonic dehydratase activity
has exact synonym: carboxyanhydrase activity
has related synonym: carbonic anhydrase A
type: Class
subclass of: GO_0016836

carbonyl reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
has exact synonym: NADPH-dependent carbonyl reductase activity
has exact synonym: NADPH2-dependent carbonyl reductase activity
has exact synonym: carbonyl reductase activity
has exact synonym: nonspecific NADPH-dependent carbonyl reductase activity
has exact synonym: secondary-alcohol:NADP+ oxidoreductase activity
has related synonym: ALR3
has related synonym: aldehyde reductase 1
has related synonym: aldehyde reductase I activity
has related synonym: prostaglandin 9-ketoreductase activity
has related synonym: xenobiotic ketone reductase activity
type: Class
subclass of: GO_0016616

carnitine O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.
has exact synonym: acetyl-CoA-carnitine O-acetyltransferase activity
has exact synonym: acetyl-CoA:carnitine O-acetyltransferase activity
has exact synonym: acetylcarnitine transferase activity
has exact synonym: carnitine acetyl coenzyme A transferase activity
has exact synonym: carnitine acetylase activity
has exact synonym: carnitine acetyltransferase activity
has exact synonym: carnitine-acetyl-CoA transferase activity
has related synonym: CATC
has related synonym: carnitine O-acetyltransferase I activity
has related synonym: carnitine O-acetyltransferase II activity
replaces: GO_0004093
replaces: GO_0004094
type: Class
subclass of: GO_0016406
subclass of: GO_0016413

carnitine O-palmitoyltransferase activity
IAO_0000115: Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
has exact synonym: L-carnitine palmitoyltransferase activity
has exact synonym: acylcarnitine transferase activity
has exact synonym: carnitine palmitoyltransferase activity
has exact synonym: outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity
has exact synonym: palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity
has exact synonym: palmitoylcarnitine transferase activity
has related synonym: CPT
has related synonym: CPT I (outer membrane carnitine palmitoyl transferase)
has related synonym: CPT-A
has related synonym: CPT-B
has related synonym: CPTi
has related synonym: CPTo
has related synonym: carnitine palmitoyltransferase I
has related synonym: carnitine palmitoyltransferase II
has related synonym: carnitine palmitoyltransferase-A
type: Class
subclass of: GO_0016406
subclass of: GO_0016416

catalase activity
IAO_0000115: Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
has exact synonym: caperase activity
has exact synonym: catalase reaction
has exact synonym: catalase-peroxidase activity
has exact synonym: equilase activity
has exact synonym: hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity
has exact synonym: optidase activity
has related synonym: CAT
has related synonym: bacterial catalase-peroxidase activity
has related synonym: haem catalase activity
has related synonym: heme catalase activity
has related synonym: manganese catalase activity
replaces: GO_0016952
replaces: GO_0016953
type: Class
subclass of: peroxidase activity

catechol oxidase activity
IAO_0000115: Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O.
has exact synonym: 1,2-benzenediol:oxygen oxidoreductase activity
has exact synonym: diphenol oxidase activity
has exact synonym: o-diphenolase activity
has exact synonym: polyphenol oxidase activity
has related synonym: catecholase
has related synonym: dopa oxidase
has related synonym: o-diphenol oxidoreductase
has related synonym: o-diphenol:oxygen oxidoreductase
has related synonym: phenolase activity
has related synonym: pyrocatechol oxidase
has related synonym: tyrosinase activity
type: Class
subclass of: GO_0016682

cerebroside-sulfatase activity
IAO_0000115: Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.
has exact synonym: arylsulfatase A activity
has exact synonym: cerebroside sulfate sulfatase activity
has exact synonym: cerebroside-3-sulfate 3-sulfohydrolase activity
has exact synonym: cerebroside-sulphatase activity
type: Class
subclass of: GO_0008484

chitin deacetylase activity
IAO_0000115: Catalysis of the reaction: chitin + H2O = chitosan + acetate.
has exact synonym: chitin amidohydrolase activity
type: Class
subclass of: GO_0016811
subclass of: GO_0019213

chitin synthase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).
has exact synonym: UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity
has exact synonym: chitin synthetase activity
has exact synonym: chitin-UDP N-acetylglucosaminyltransferase activity
has exact synonym: chitin-UDP acetyl-glucosaminyl transferase activity
has exact synonym: chitin-uridine diphosphate acetylglucosaminyltransferase activity
has exact synonym: trans-N-acetylglucosaminosylase activity
type: Class
subclass of: GO_0008375

choline O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
has exact synonym: CHOACTase activity
has exact synonym: acetyl-CoA:choline O-acetyltransferase activity
has exact synonym: choline acetylase activity
has exact synonym: choline acetyltransferase activity
type: Class
subclass of: GO_0016413

choline kinase activity
IAO_0000115: Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
has related synonym: ATP:choline phosphotransferase activity
has related synonym: choline kinase (phosphorylating)
has related synonym: choline phosphokinase activity
has related synonym: choline-ethanolamine kinase activity
type: Class
subclass of: part-of-parent-6657
subclass of: GO_0016301
subclass of: GO_0016773

cholinesterase activity
IAO_0000115: Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
has exact synonym: BtChoEase activity
has exact synonym: acylcholine acylhydrolase activity
has exact synonym: anticholineesterase activity
has exact synonym: benzoylcholinesterase activity
has exact synonym: butyrylcholine esterase activity
has exact synonym: butyrylcholinesterase activity
has exact synonym: choline esterase II (unspecific) activity
has exact synonym: choline esterase activity
has exact synonym: non-specific cholinesterase activity
has exact synonym: propionylcholinesterase activity
has exact synonym: pseudocholinesterase activity
type: Class
subclass of: GO_0052689

choline-phosphate cytidylyltransferase activity
IAO_0000115: Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.
has exact synonym: CDP-choline pyrophosphorylase activity
has exact synonym: CDP-choline synthetase activity
has exact synonym: CTP-phosphocholine cytidylyltransferase activity
has exact synonym: CTP:choline-phosphate cytidylyltransferase activity
has exact synonym: CTP:phosphocholine cytidylyltransferase activity
has exact synonym: CTP:phosphorylcholine cytidylyltransferase activity
has exact synonym: choline phosphate cytidylyltransferase activity
has exact synonym: cytidine diphosphocholine pyrophosphorylase activity
has exact synonym: phosphocholine cytidylyltransferase activity
has exact synonym: phosphorylcholine cytidylyltransferase activity
has exact synonym: phosphorylcholine transferase activity
has exact synonym: phosphorylcholine:CTP cytidylyltransferase activity
type: Class
subclass of: part-of-parent-6657
subclass of: GO_0070567

chorismate mutase activity
IAO_0000115: Catalysis of the reaction: chorismate = prephenate.
has exact synonym: chorismate pyruvatemutase activity
has related synonym: hydroxyphenylpyruvate synthase activity
type: Class
subclass of: GO_0016866

chorismate synthase activity
IAO_0000115: Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.
has exact synonym: 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)
has exact synonym: 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity
has exact synonym: 5-enolpyruvylshikimate-3-phosphate phospholyase activity
type: Class
subclass of: GO_0016838

citrate (Si)-synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
has exact synonym: (R)-citric synthase activity
has exact synonym: citrate condensing enzyme activity
has exact synonym: citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
has exact synonym: citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
has exact synonym: citrate oxaloacetate-lyase, CoA-acetylating activity
has exact synonym: citrate synthetase activity
has exact synonym: citric synthase activity
has exact synonym: citric-condensing enzyme activity
has exact synonym: citrogenase activity
has exact synonym: oxalacetic transacetase activity
has exact synonym: oxaloacetate transacetase activity
has related synonym: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
has related synonym: citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
has related synonym: citrate synthase activity
has related synonym: condensing enzyme activity
type: Class
subclass of: GO_0036440

coproporphyrinogen oxidase activity
IAO_0000115: Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.
has exact synonym: coprogen oxidase activity
has exact synonym: coproporphyrinogen-III oxidase activity
has exact synonym: coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
has exact synonym: coproporphyrinogenase activity
type: Class
subclass of: GO_0016634

corticosteroid side-chain-isomerase activity
IAO_0000115: Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al.
has exact synonym: 11-deoxycorticosterone aldose-ketose-isomerase activity
has exact synonym: 11-deoxycorticosterone ketol-isomerase activity
type: Class
subclass of: GO_0016861

creatine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
has exact synonym: ATP:creatine N-phosphotransferase activity
has exact synonym: ATP:creatine phosphotransferase activity
has exact synonym: adenosine triphosphate-creatine transphosphorylase activity
has exact synonym: creatine phosphokinase activity
has exact synonym: creatine phosphotransferase activity
has exact synonym: phosphocreatine kinase activity
has related synonym: BB-CK
has related synonym: CK
has related synonym: CK-BB
has related synonym: CK-MB
has related synonym: CK-MM
has related synonym: CKMiMi
has related synonym: MB-CK
has related synonym: MM-CK
has related synonym: Mi-CK
has related synonym: MiMi-CK
type: Class
subclass of: GO_0016301
subclass of: GO_0016775

cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
type: Class
subclass of: GO_0008081

2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
has exact synonym: 2',3'-cyclic AMP phosphodiesterase activity
has exact synonym: 2',3'-cyclic nucleotide 3'-phosphodiesterase activity
has exact synonym: 2',3'-cyclic nucleotide 3'-phosphohydrolase activity
has exact synonym: 2':3'-CNMP-3'-ase activity
has exact synonym: 2':3'-cyclic nucleotide 3'-phosphodiesterase activity
has exact synonym: CNPase activity
has exact synonym: cyclic 2',3'-nucleotide 3'-phosphodiesterase activity
has exact synonym: nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity
has related synonym: 2',3'-cyclic nucleoside monophosphate phosphodiesterase
has related synonym: 2',3'-cyclic nucleotide phosphohydrolase
has related synonym: cyclic 2',3'-nucleotide phosphodiesterase
has related synonym: cyclic-CMP phosphodiesterase activity
type: Class
subclass of: cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
has exact synonym: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity
has exact synonym: 3',5' cyclic-nucleotide phosphodiesterase activity
has exact synonym: 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity
has exact synonym: 3',5'-cyclonucleotide phosphodiesterase activity
has exact synonym: 3',5'-nucleotide phosphodiesterase activity
has exact synonym: 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity
has exact synonym: 3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity
has exact synonym: cyclic 3',5'-mononucleotide phosphodiesterase activity
has exact synonym: cyclic 3',5'-nucleotide phosphodiesterase activity
has exact synonym: cyclic 3',5'-phosphodiesterase activity
has exact synonym: cyclic 3',5-nucleotide monophosphate phosphodiesterase activity
has exact synonym: cyclic nucleotide phosphodiesterase activity
has exact synonym: cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity
has exact synonym: nucleoside 3',5'-cyclic phosphate diesterase activity
has exact synonym: nucleoside-3',5-monophosphate phosphodiesterase activity
has related synonym: PDE
has related synonym: cyclic AMP phosphodiesterase activity
type: Class
subclass of: cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
has exact synonym: 3',5' cAMP-specific phosphodiesterase activity
has exact synonym: 3',5'-cAMP-specific phosphodiesterase activity
has exact synonym: 3',5'-cyclic-AMP-specific phosphodiesterase activity
has exact synonym: adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
has exact synonym: cAMP-specific phosphodiesterase activity
has exact synonym: cyclic AMP-specific phosphodiesterase activity
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

photoreceptor cyclic-nucleotide phosphodiesterase activity
IAO_0000115: Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide.
type: Class
subclass of: 3',5'-cyclic-nucleotide phosphodiesterase activity

cystathionine beta-lyase activity
IAO_0000115: Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate.
has exact synonym: L-cystathionine L-homocysteine-lyase (deaminating)
has exact synonym: L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)
has exact synonym: beta C-S lyase activity
has exact synonym: beta-cystathionase activity
has exact synonym: cystathionine L-homocysteine-lyase (deaminating)
has exact synonym: cystine lyase activity
replaces: GO_0008799
type: Class
subclass of: GO_0016846

cystathionine beta-synthase activity
IAO_0000115: Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
has exact synonym: L-serine hydro-lyase (adding homocysteine)
has exact synonym: L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
has exact synonym: beta-thionase activity
has exact synonym: methylcysteine synthase activity
has exact synonym: serine sulfhydrase activity
has exact synonym: serine sulfhydrylase activity
type: Class
subclass of: GO_0016836

cystathionine gamma-lyase activity
IAO_0000115: Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
has exact synonym: L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
has related synonym: L-cystathionine cysteine-lyase (deaminating)
has related synonym: gamma-cystathionase activity
has related synonym: homoserine deaminase activity
has related synonym: homoserine deaminase-cystathionase activity
has related synonym: homoserine dehydratase activity
replaces: GO_0016225
type: Class
subclass of: GO_0016846

cysteine synthase activity
IAO_0000115: Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
has exact synonym: 3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
has exact synonym: O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity
has exact synonym: O-acetyl-L-serine sulfhydrylase activity
has exact synonym: O-acetyl-L-serine sulfohydrolase activity
has exact synonym: O-acetylserine (thiol)-lyase activity
has exact synonym: O-acetylserine sulfhydrylase activity
has exact synonym: O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)
has exact synonym: O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity
has exact synonym: OAS sulfhydrylase activity
has exact synonym: acetylserine sulfhydrylase activity
has exact synonym: cysteine synthetase activity
has related synonym: O-acetylserine (thiol)-lyase A activity
type: Class
subclass of: part-of-parent-19344
subclass of: GO_0016765

L-seryl-tRNASec selenium transferase activity
IAO_0000115: Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.
has exact synonym: L-selenocysteinyl-tRNA(Sec) synthase activity
has exact synonym: L-selenocysteinyl-tRNA(Sel) synthase activity
has exact synonym: L-selenocysteinyl-tRNASec synthase activity
has exact synonym: L-selenocysteinyl-tRNASel synthase activity
has exact synonym: L-seryl-tRNA(Ser) selenium transferase activity
has exact synonym: cysteinyl-tRNA(Sec)-selenium transferase activity
has exact synonym: cysteinyl-tRNA(Sel)-selenium transferase activity
has exact synonym: cysteinyl-tRNA(Ser) selenium transferase activity
has exact synonym: cysteinyl-tRNASec-selenium transferase activity
has exact synonym: cysteinyl-tRNASel-selenium transferase activity
has exact synonym: selenocysteine synthase activity
has exact synonym: selenocysteinyl-tRNA(Ser) synthase activity
has exact synonym: selenophosphate:L-seryl-tRNASec selenium transferase activity
type: Class
subclass of: GO_0016785
subclass of: GO_0140101

cytidine deaminase activity
IAO_0000115: Catalysis of the reaction: cytidine + H2O = uridine + NH3.
has exact synonym: cytidine aminohydrolase activity
has exact synonym: cytosine nucleoside deaminase activity
type: Class
subclass of: part-of-parent-9972
subclass of: GO_0016814
subclass of: GO_0019239

cytidylate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.
has exact synonym: ATP:CMP phosphotransferase activity
has exact synonym: ATP:UMP-CMP phosphotransferase activity
has exact synonym: CTP:CMP phosphotransferase activity
has exact synonym: UMP-CMP kinase activity
has exact synonym: cytidine monophosphate kinase activity
has exact synonym: deoxycytidine monophosphokinase activity
has exact synonym: pyrimidine nucleoside monophosphate kinase activity
has related synonym: CMP kinase activity
has related synonym: dCMP kinase activity
has related synonym: deoxycytidylate kinase activity
type: Class
subclass of: GO_0050145

cytochrome-b5 reductase activity, acting on NAD(P)H
IAO_0000115: Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
has exact synonym: NADH 5alpha-reductase activity
has exact synonym: NADH-cytochrome b5 reductase activity
has exact synonym: NADH-cytochrome-b5 reductase activity
has exact synonym: NADH-ferricytochrome b5 oxidoreductase activity
has exact synonym: NADH:ferricytochrome-b5 oxidoreductase activity
has exact synonym: cytochrome b5 reductase activity
has exact synonym: dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
has exact synonym: reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity
type: Class
subclass of: GO_0016653

cytochrome-c oxidase activity
IAO_0000115: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
has exact synonym: NADH cytochrome c oxidase
has exact synonym: cytochrome c oxidase activity
has related synonym: aa3-type cytochrome c oxidase
has related synonym: ba3-type cytochrome c oxidase
has related synonym: caa3-type cytochrome c oxidase
has related synonym: cbb3-type cytochrome c oxidase
has related synonym: complex IV (mitochondrial electron transport) activity
has related synonym: cytochrome a3 activity
has related synonym: cytochrome aa3 activity
has related synonym: cytochrome oxidase activity
has related synonym: ferrocytochrome c oxidase
has related synonym: ferrocytochrome-c:oxygen oxidoreductase
has related synonym: indophenol oxidase
has related synonym: indophenolase
has related synonym: warburg's respiratory enzyme activity
type: Class
subclass of: GO_0009055
subclass of: GO_0015002
subclass of: GO_0015078
subclass of: GO_0016676

cytochrome-c peroxidase activity
IAO_0000115: Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O.
has exact synonym: apocytochrome c peroxidase activity
has exact synonym: cytochrome c peroxidase activity
has exact synonym: cytochrome c-551 peroxidase activity
has exact synonym: cytochrome c-H2O oxidoreductase activity
has exact synonym: cytochrome peroxidase activity
has exact synonym: ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity
has related synonym: mesocytochrome c peroxidase azide
has related synonym: mesocytochrome c peroxidase cyanate
has related synonym: mesocytochrome c peroxidase cyanide
type: Class
subclass of: peroxidase activity

cytosine deaminase activity
IAO_0000115: Catalysis of the reaction: cytosine + H2O = uracil + NH3.
has exact synonym: cytosine aminohydrolase activity
has exact synonym: isocytosine deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

dCMP deaminase activity
IAO_0000115: Catalysis of the reaction: dCMP + H2O = dUMP + NH3.
has exact synonym: dCMP aminohydrolase activity
has exact synonym: deoxy-CMP-deaminase activity
has exact synonym: deoxycytidine monophosphate deaminase activity
has exact synonym: deoxycytidine-5'-monophosphate aminohydrolase activity
has exact synonym: deoxycytidine-5'-phosphate deaminase activity
has exact synonym: deoxycytidylate aminohydrolase activity
has exact synonym: deoxycytidylate deaminase activity
type: Class
subclass of: GO_0016814
subclass of: GO_0019239

glycogen debranching enzyme activity
IAO_0000115: Catalysis of the cleavage of branch points in branched glycogen polymers.
type: Class
subclass of: catalytic activity
subclass of: part-of-parent-5977

4-alpha-glucanotransferase activity
IAO_0000115: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.
has exact synonym: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity
has exact synonym: amylomaltase activity
has exact synonym: debranching enzyme maltodextrin glycosyltransferase activity
has exact synonym: dextrin transglycosylase activity
has exact synonym: oligo-1,4-1,4-glucantransferase activity
has related synonym: D-enzyme activity
has related synonym: dextrin glycosyltransferase activity
has related synonym: disproportionating enzyme activity
type: Class
subclass of: glycogen debranching enzyme activity
subclass of: GO_0016758

amylo-alpha-1,6-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.
has exact synonym: amylo-1,6-glucosidase activity
has exact synonym: amylopectin 1,6-glucosidase activity
has exact synonym: dextrin-1,6-glucosidase activity
has exact synonym: glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity
has related synonym: dextrin 6-alpha-D-glucosidase activity
type: Class
subclass of: glycogen debranching enzyme activity
subclass of: GO_0090599

deoxyadenosine kinase activity
IAO_0000115: Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+).
has exact synonym: ATP:deoxyadenosine 5'-phosphotransferase activity
has exact synonym: deoxyadenosine kinase (phosphorylating)
has exact synonym: purine-deoxyribonucleoside kinase activity
type: Class
subclass of: part-of-parent-6170
subclass of: GO_0019136

deoxycytidine kinase activity
IAO_0000115: Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
has exact synonym: 2'-deoxycytidine kinase activity
has exact synonym: Ara-C kinase activity
has exact synonym: NTP:deoxycytidine 5'-phosphotransferase activity
has exact synonym: arabinofuranosylcytosine kinase activity
has exact synonym: deoxycytidine kinase (phosphorylating)
has exact synonym: deoxycytidine-cytidine kinase activity
type: Class
subclass of: GO_0019136

deoxyguanosine kinase activity
IAO_0000115: Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
has exact synonym: (dihydroxypropoxymethyl)guanine kinase activity
has exact synonym: 2'-deoxyguanosine kinase activity
has exact synonym: ATP:deoxyguanosine 5'-phosphotransferase activity
has exact synonym: NTP-deoxyguanosine 5'-phosphotransferase activity
has exact synonym: deoxyguanosine kinase (phosphorylating)
type: Class
subclass of: GO_0019136

deoxyribose-phosphate aldolase activity
IAO_0000115: Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
has exact synonym: 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
has exact synonym: 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity
has exact synonym: 2-deoxyribose-5-phosphate aldolase activity
has exact synonym: deoxyribose-5-phosphate aldolase activity
has exact synonym: phosphodeoxyriboaldolase activity
has related synonym: deoxyriboaldolase activity
type: Class
subclass of: GO_0016832

dephospho-CoA kinase activity
IAO_0000115: Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+).
has exact synonym: 3'-dephospho-CoA kinase activity
has exact synonym: ATP:dephospho-CoA 3'-phosphotransferase activity
has exact synonym: dephosphocoenzyme A kinase (phosphorylating)
has related synonym: dephosphocoenzyme A kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

dethiobiotin synthase activity
IAO_0000115: Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate.
has exact synonym: 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)
has exact synonym: DTB synthetase activity
has exact synonym: desthiobiotin synthase activity
type: Class
subclass of: GO_0016882

diacylglycerol cholinephosphotransferase activity
IAO_0000115: Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.
has exact synonym: 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity
has exact synonym: 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity
has exact synonym: 1-alkyl-2-acetylglycerol cholinephosphotransferase activity
has exact synonym: CDP-choline diglyceride phosphotransferase activity
has exact synonym: CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity
has exact synonym: alkylacylglycerol choline phosphotransferase activity
has exact synonym: alkylacylglycerol cholinephosphotransferase activity
has exact synonym: cytidine diphosphocholine glyceride transferase activity
has exact synonym: cytidine diphosphorylcholine diglyceride transferase activity
has exact synonym: diacylglycerol choline phosphotransferase activity
has exact synonym: phosphocholine diacylglyceroltransferase activity
has exact synonym: phosphorylcholine--glyceride transferase activity
has exact synonym: sn-1,2-diacylglycerol cholinephosphotransferase activity
has related synonym: CPT
has related synonym: cholinephosphotransferase activity
type: Class
subclass of: part-of-parent-6657
subclass of: GO_0017169

diacylglycerol kinase activity
IAO_0000115: Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
has exact synonym: 1,2-diacylglycerol kinase (phosphorylating)
has exact synonym: 1,2-diacylglycerol kinase activity
has exact synonym: DG kinase activity
has exact synonym: DGK activity
has exact synonym: arachidonoyl-specific diacylglycerol kinase activity
has exact synonym: diglyceride kinase activity
has exact synonym: sn-1,2-diacylglycerol kinase activity
has related synonym: ATP:1,2-diacylglycerol 3-phosphotransferase activity
has related synonym: ATP:diacylglycerol phosphotransferase activity
has related synonym: CTP:diacylglycerol kinase activity
has related synonym: diacylglycerol:ATP kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

diacylglycerol O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
has exact synonym: 1,2-diacylglycerol acyltransferase activity
has exact synonym: acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
has exact synonym: diacylglycerol acyltransferase activity
has exact synonym: diglyceride O-acyltransferase activity
has exact synonym: diglyceride acyltransferase activity
has exact synonym: palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
type: Class
subclass of: GO_0016411

diamine N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
has exact synonym: acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity
has exact synonym: diamine acetyltransferase activity
has exact synonym: spermidine N1-acetyltransferase activity
has exact synonym: spermidine/spermine N1-acetyltransferase activity
has related synonym: acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity
has related synonym: putrescine (diamine)-acetylating enzyme activity
has related synonym: putrescine N-acetyltransferase activity
has related synonym: putrescine acetylase activity
has related synonym: putrescine acetyltransferase activity
has related synonym: spermidine N(1)-acetyltransferase activity
has related synonym: spermidine acetyltransferase activity
has related synonym: spermine N(1)-acetyltransferase
has related synonym: spermine N-acetyltransferase
has related synonym: spermine acetyltransferase
type: Class
subclass of: GO_0008080

dihydrofolate reductase activity
IAO_0000115: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
has exact synonym: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
has exact synonym: 7,8-dihydrofolate reductase activity
has exact synonym: NADPH-dihydrofolate reductase activity
has exact synonym: dihydrofolate reductase:thymidylate synthase activity
has exact synonym: dihydrofolate reduction
has exact synonym: dihydrofolic acid reductase activity
has exact synonym: dihydrofolic reductase activity
has exact synonym: folic acid reductase activity
has exact synonym: folic reductase activity
has exact synonym: pteridine reductase:dihydrofolate reductase activity
has exact synonym: tetrahydrofolate dehydrogenase activity
has exact synonym: thymidylate synthetase-dihydrofolate reductase activity
has related synonym: DHFR
type: Class
subclass of: GO_0016646

dihydrolipoamide branched chain acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain.
has exact synonym: dihydrolipoamide branched chain transacylase activity
type: Class
subclass of: GO_0030523

dihydrolipoyl dehydrogenase activity
IAO_0000115: Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
has exact synonym: dehydrolipoate dehydrogenase activity
has exact synonym: diaphorase activity
has exact synonym: dihydrolipoamide dehydrogenase activity
has exact synonym: dihydrolipoamide:NAD+ oxidoreductase
has exact synonym: dihydrolipoic dehydrogenase activity
has exact synonym: dihydrothioctic dehydrogenase activity
has exact synonym: lipoamide dehydrogenase (NADH) activity
has exact synonym: lipoamide oxidoreductase (NADH) activity
has exact synonym: lipoamide reductase (NADH) activity
has exact synonym: lipoamide reductase activity
has exact synonym: lipoate dehydrogenase activity
has exact synonym: lipoic acid dehydrogenase activity
has exact synonym: lipoyl dehydrogenase activity
has exact synonym: protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
has exact synonym: protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
has related synonym: E3 component of alpha-ketoacid dehydrogenase complexes activity
has related synonym: L-protein activity
has related synonym: LDP-Glc activity
has related synonym: LDP-Val activity
has related synonym: dihydrolipoamide reduction
has related synonym: dihydrolipoylprotein reduction
has related synonym: glycine-cleavage system L-protein activity
type: Class
subclass of: GO_0016668

dihydrolipoyllysine-residue succinyltransferase activity
IAO_0000115: Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
has exact synonym: dihydrolipoamide S-succinyltransferase activity
has exact synonym: dihydrolipoamide succinyltransferase activity
has exact synonym: dihydrolipoic transsuccinylase activity
has exact synonym: dihydrolipolyl transsuccinylase activity
has exact synonym: dihydrolipoyl transsuccinylase activity
has exact synonym: enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
has exact synonym: lipoate succinyltransferase (Escherichia coli) activity
has exact synonym: lipoate succinyltransferase activity
has exact synonym: lipoic transsuccinylase activity
has exact synonym: lipoyl transsuccinylase activity
has exact synonym: succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
has exact synonym: succinyl-CoA:dihydrolipoate S-succinyltransferase activity
has exact synonym: succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
has exact synonym: succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity
type: Class
subclass of: GO_0016751
subclass of: GO_0140096

dihydroneopterin aldolase activity
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
has exact synonym: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)
has exact synonym: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity
type: Class
subclass of: GO_0016832

dihydroorotase activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+).
has exact synonym: (S)-dihydroorotate amidohydrolase activity
has exact synonym: DHOase activity
has exact synonym: carbamoylaspartic dehydrase activity
has exact synonym: dihydroorotate hydrolase activity
type: Class
subclass of: GO_0016812

dihydroorotate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
has exact synonym: (S)-dihydroorotate:quinone oxidoreductase activity
has exact synonym: DHOdehase activity
has exact synonym: dihydoorotic acid dehydrogenase activity
has related synonym: (DHO) dehydrogenase activity
has related synonym: dihydroorotate:ubiquinone oxidoreductase activity
type: Class
subclass of: GO_0016635

dihydropterin deaminase activity
IAO_0000115: Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.
type: Class
subclass of: GO_0019239

dihydropterin oxidase activity
IAO_0000115: Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide.
type: Class
subclass of: GO_0016491

6,7-dihydropteridine reductase activity
IAO_0000115: Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.
has exact synonym: 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity
has exact synonym: 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity
has exact synonym: 6,7-dihydropteridine:NAD(P)H oxidoreductase activity
has exact synonym: DHPR activity
has exact synonym: NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity
has exact synonym: NAD(P)H2:6,7-dihydropteridine oxidoreductase activity
has exact synonym: NADH-dihydropteridine reductase activity
has exact synonym: NADPH-dihydropteridine reductase activity
has exact synonym: NADPH-specific dihydropteridine reductase activity
has exact synonym: dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity
has exact synonym: dihydropteridine reductase (NADH) activity
has exact synonym: dihydropteridine reductase activity
has related synonym: dihydropteridine reduction
type: Class
subclass of: GO_0016646

dihydropteroate synthase activity
IAO_0000115: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
has exact synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
has exact synonym: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity
has exact synonym: 7,8-dihydropteroate synthase activity
has exact synonym: 7,8-dihydropteroate synthetase activity
has exact synonym: 7,8-dihydropteroic acid synthetase activity
has exact synonym: DHPS activity
has exact synonym: dihydropteroate diphosphorylase activity
has exact synonym: dihydropteroate pyrophosphorylase activity
has exact synonym: dihydropteroate synthetase activity
has exact synonym: dihydropteroic synthetase activity
type: Class
subclass of: GO_0016765

dihydropyrimidinase activity
IAO_0000115: Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.
has exact synonym: 5,6-dihydropyrimidine amidohydrolase activity
has exact synonym: D-hydantoinase activity
has exact synonym: hydantoin peptidase activity
has exact synonym: hydantoinase activity
has exact synonym: hydropyrimidine hydrase activity
has exact synonym: pyrimidine hydrase activity
type: Class
subclass of: GO_0016812

dihydroorotate oxidase activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate.
has exact synonym: (S)-dihydroorotate:oxygen oxidoreductase activity
has exact synonym: 4,5-L-dihydroorotate:oxygen oxidoreductase activity
type: Class
subclass of: dihydroorotate dehydrogenase activity
subclass of: GO_0016634

dihydrouracil dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+.
has exact synonym: 5,6-dihydrouracil:NAD+ oxidoreductase activity
has exact synonym: dehydrogenase, dihydrouracil
has exact synonym: pyrimidine reductase activity
has exact synonym: thymine reductase activity
has exact synonym: uracil reductase activity
type: Class
subclass of: GO_0016628

dihydroxy-acid dehydratase activity
IAO_0000115: Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
has exact synonym: 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
has exact synonym: 2,3-dihydroxy-acid hydro-lyase activity
has exact synonym: 2,3-dihydroxyisovalerate dehydratase activity
has exact synonym: acetohydroxyacid dehydratase activity
has exact synonym: alpha,beta-dihydroxyacid dehydratase activity
has exact synonym: alpha,beta-dihydroxyisovalerate dehydratase activity
has exact synonym: dihydroxy acid dehydrase activity
has related synonym: DHAD
type: Class
subclass of: GO_0016836

dimethylallyltranstransferase activity
IAO_0000115: Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
has exact synonym: (2E,6E)-farnesyl diphosphate synthetase activity
has exact synonym: DMAPP:IPP-dimethylallyltransferase activity
has exact synonym: dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity
has exact synonym: dimethylallyltransferase activity
has exact synonym: diprenyltransferase activity
has exact synonym: geranyl diphosphate synthase
has exact synonym: geranyl pyrophosphate synthase activity
has exact synonym: geranyl pyrophosphate synthetase activity
has exact synonym: trans-farnesyl pyrophosphate synthetase activity
has related synonym: geranyl-diphosphate synthase activity
type: Class
subclass of: prenyltransferase activity

dimethylnitrosamine demethylase activity
IAO_0000115: Catalysis of the removal of a methyl group from N-nitrosodimethylamine.
has exact synonym: N-nitrosodimethylamine demethylase activity
type: Class
subclass of: GO_0032451

diphosphomevalonate decarboxylase activity
IAO_0000115: Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.
has exact synonym: 5-pyrophosphomevalonate decarboxylase activity
has exact synonym: ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
has exact synonym: ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)
has exact synonym: mevalonate 5-diphosphate decarboxylase activity
has exact synonym: mevalonate diphosphate decarboxylase activity
has exact synonym: mevalonate pyrophosphate decarboxylase activity
has exact synonym: mevalonate-5-pyrophosphate decarboxylase activity
has exact synonym: pyrophosphomevalonate decarboxylase activity
has exact synonym: pyrophosphomevalonic acid decarboxylase activity
type: Class
subclass of: GO_0016831

diphthine synthase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.
has exact synonym: S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity
has exact synonym: diphthine methyltransferase activity
type: Class
subclass of: GO_0008757

dodecenoyl-CoA delta-isomerase activity
IAO_0000115: Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA.
has exact synonym: 3,2-trans-enoyl-CoA isomerase activity
has exact synonym: acetylene-allene isomerase activity
has exact synonym: delta(3),Delta(2)-enoyl-CoA isomerase activity
has exact synonym: delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity
has exact synonym: delta3,Delta2-enoyl-CoA isomerase activity
has exact synonym: dodecenoyl-CoA (3Z)-(2E)-isomerase activity
has exact synonym: dodecenoyl-CoA D-isomerase activity
has exact synonym: dodecenoyl-CoA Delta-isomerase activity
has exact synonym: dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity
has exact synonym: dodecenoyl-CoA isomerase activity
has related synonym: delta3-cis-delta2-trans-enoyl-CoA isomerase
replaces: GO_0008461
type: Class
subclass of: GO_0016863

dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.
has exact synonym: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity
has exact synonym: UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity
has exact synonym: dolichyl phosphate N-acetylglucosaminyltransferase activity
has exact synonym: dolichyl phosphate acetylglucosaminyltransferase activity
has exact synonym: dolichyl-phosphate N-acetylglucosaminyltransferase activity
has exact synonym: dolichyl-phosphate acetylglucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity
replaces: GO_0004101
type: Class
subclass of: GO_0008375

dopachrome isomerase activity
IAO_0000115: Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
has exact synonym: DCF activity
has exact synonym: DCT activity
has exact synonym: L-dopachrome isomerase activity
has exact synonym: L-dopachrome keto-enol isomerase activity
has exact synonym: L-dopachrome-methyl ester tautomerase activity
has exact synonym: TRP activity
has exact synonym: dopachrome Delta(7),Delta(2)-isomerase activity
has exact synonym: dopachrome delta-isomerase activity
has exact synonym: dopachrome delta7,Delta2-isomerase activity
has exact synonym: dopachrome keto-enol isomerase activity
has exact synonym: dopachrome oxidoreductase activity
has exact synonym: dopachrome rearranging enzyme activity
has exact synonym: dopachrome tautomerase activity
has exact synonym: tyrosinase-related protein 2 activity
has related synonym: TRP-1
has related synonym: TRP-2
has related synonym: TRP2
has related synonym: dopachrome conversion activity
has related synonym: dopachrome conversion factor activity
has related synonym: dopachrome-rearranging enzyme
has related synonym: tryosinase-related protein-2
replaces: GO_0048059
type: Class
subclass of: GO_0016863

dolichol kinase activity
IAO_0000115: Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.
has exact synonym: CTP:dolichol O-phosphotransferase activity
has exact synonym: dolichol phosphokinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

dolichyl-phosphate-mannose-protein mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.
has exact synonym: dolichol phosphomannose-protein mannosyltransferase activity
has exact synonym: dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity
has exact synonym: dolichyl-phosphate-mannose-protein O-mannosyltransferase activity
has exact synonym: protein O-D-mannosyltransferase activity
has exact synonym: protein O-mannosyltransferase activity
has related synonym: O-glycoside mannosyltransferase
type: Class
subclass of: mannosyltransferase activity
subclass of: part-of-parent-35269

dUTP diphosphatase activity
IAO_0000115: Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate.
has exact synonym: dUTP nucleotidohydrolase activity
has exact synonym: dUTP pyrophosphatase activity
has exact synonym: dUTPase activity
has exact synonym: deoxyuridine-triphosphatase activity
has exact synonym: desoxyuridine 5'-triphosphatase activity
has exact synonym: desoxyuridine 5'-triphosphate nucleotidohydrolase activity
type: Class
subclass of: GO_0047429

obsolete deoxyhypusine synthase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
type: Class
subclass of: ObsoleteClass

obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

ecdysone O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate.
has exact synonym: acyl-CoA:ecdysone acyltransferase activity
has exact synonym: fatty acyl-CoA:ecdysone acyltransferase activity
has exact synonym: palmitoyl-CoA:ecdysone palmitoyltransferase activity
type: Class
subclass of: GO_0008374

electron-transferring-flavoprotein dehydrogenase activity
IAO_0000115: Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol.
has exact synonym: ETF dehydrogenase activity
has exact synonym: ETF-QO activity
has exact synonym: ETF-ubiquinone oxidoreductase activity
has exact synonym: ETF:ubiquinone oxidoreductase activity
has exact synonym: electron transfer flavoprotein Q oxidoreductase activity
has exact synonym: electron transfer flavoprotein dehydrogenase activity
has exact synonym: electron transfer flavoprotein reductase activity
has exact synonym: electron transfer flavoprotein-ubiquinone oxidoreductase activity
has exact synonym: electron-transferring-flavoprotein:ubiquinone oxidoreductase activity
type: Class
subclass of: part-of-parent-22904
subclass of: GO_0009055
subclass of: GO_0016649

endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
has related synonym: elastase activity
has related synonym: endoprotease activity
has related synonym: proteasome endopeptidase activity
has related synonym: proteinase
replaces: GO_0016809
type: Class
subclass of: GO_0008233

ATP-dependent peptidase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.
has related synonym: ATP-dependent proteolysis
replaces: GO_0004280
type: Class
subclass of: GO_0008233
subclass of: GO_0016887

aminopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
type: Class
subclass of: GO_0008238

obsolete leucyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.
type: Class
subclass of: ObsoleteClass

obsolete membrane alanyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
type: Class
subclass of: ObsoleteClass

carboxypeptidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
type: Class
subclass of: GO_0008238

metallocarboxypeptidase activity
IAO_0000115: Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
type: Class
subclass of: carboxypeptidase activity
subclass of: GO_0008235

obsolete carboxypeptidase A activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
replaces: GO_0008731
type: Class
subclass of: ObsoleteClass

obsolete carboxypeptidase E activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.
type: Class
subclass of: ObsoleteClass

obsolete lysine carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
type: Class
subclass of: ObsoleteClass

serine-type carboxypeptidase activity
IAO_0000115: Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
has exact synonym: serine carboxypeptidase activity
type: Class
subclass of: carboxypeptidase activity
subclass of: GO_0070008

obsolete carboxypeptidase C activity
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.
type: Class
subclass of: ObsoleteClass

obsolete carboxypeptidase D activity
IAO_0000115: OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.
type: Class
subclass of: ObsoleteClass

obsolete serine-type Pro-X carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
replaces: GO_0008323
type: Class
subclass of: ObsoleteClass

obsolete tubulinyl-Tyr carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
type: Class
subclass of: ObsoleteClass

aspartic-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
has exact synonym: aspartic endopeptidase activity
has related synonym: aspartate protease activity
has related synonym: aspartic protease activity
has related synonym: aspartyl protease activity
has related synonym: carboxyl protease activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0070001

obsolete barrierpepsin activity
IAO_0000115: OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin D activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin E activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.
type: Class
subclass of: ObsoleteClass

obsolete pepsin A activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.
type: Class
subclass of: ObsoleteClass

obsolete renin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.
type: Class
subclass of: ObsoleteClass

obsolete saccharopepsin activity
IAO_0000115: OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.
type: Class
subclass of: ObsoleteClass

cysteine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
has exact synonym: thiol endopeptidase activity
has related synonym: caspase activity
has related synonym: lysosomal cysteine-type endopeptidase
has related synonym: metacaspase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008234

calcium-dependent cysteine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
has related synonym: calpain activity
type: Class
subclass of: cysteine-type endopeptidase activity

obsolete signaling (initiator) caspase activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-1 activity
IAO_0000115: OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec.
type: Class
subclass of: ObsoleteClass

obsolete caspase-2 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-4 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-5 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-8 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-10 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete effector caspase activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-3 activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis.
type: Class
subclass of: ObsoleteClass

obsolete caspase-6 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-7 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete caspase-9 activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete lysosomal cysteine-type endopeptidase
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete cathepsin B activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
type: Class
subclass of: ObsoleteClass

obsolete dipeptidyl-peptidase I activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin H activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin K activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin L activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin S activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.
type: Class
subclass of: ObsoleteClass

obsolete pyroglutamyl-peptidase I activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.
type: Class
subclass of: ObsoleteClass

obsolete ubiquitin thiolesterase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
replaces: GO_0008577
type: Class
subclass of: ObsoleteClass

metalloendopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
has related synonym: metalloendoprotease activity
has related synonym: metalloendoproteinase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008237

obsolete Gly-X carboxypeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.
type: Class
subclass of: ObsoleteClass

obsolete gelatinase A activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.
type: Class
subclass of: ObsoleteClass

obsolete gelatinase B activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.
type: Class
subclass of: ObsoleteClass

obsolete glutamyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
type: Class
subclass of: ObsoleteClass

obsolete insulysin activity
IAO_0000115: OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.
type: Class
subclass of: ObsoleteClass

obsolete interstitial collagenase activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
type: Class
subclass of: ObsoleteClass

obsolete macrophage elastase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.
type: Class
subclass of: ObsoleteClass

obsolete matrilysin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
type: Class
subclass of: ObsoleteClass

obsolete membrane dipeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of dipeptides.
type: Class
subclass of: ObsoleteClass

obsolete meprin A activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
type: Class
subclass of: ObsoleteClass

obsolete methionyl aminopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
type: Class
subclass of: ObsoleteClass

obsolete mitochondrial processing peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
type: Class
subclass of: ObsoleteClass

obsolete alpha-mitochondrial processing peptidase
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete beta-mitochondrial processing peptidase
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete mitochondrial intermediate peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.
type: Class
subclass of: ObsoleteClass

obsolete mitochondrial inner membrane peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.
type: Class
subclass of: ObsoleteClass

obsolete neprilysin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
type: Class
subclass of: ObsoleteClass

obsolete peptidyl-dipeptidase A activity
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
type: Class
subclass of: ObsoleteClass

obsolete saccharolysin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.
type: Class
subclass of: ObsoleteClass

obsolete stromelysin 1 activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.
type: Class
subclass of: ObsoleteClass

obsolete stromelysin 3 activity
IAO_0000115: OBSOLETE. Was not defined before being made obsolete.
type: Class
subclass of: ObsoleteClass

obsolete aminopeptidase I activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.
type: Class
subclass of: ObsoleteClass

obsolete X-Pro dipeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
type: Class
subclass of: ObsoleteClass

serine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
has related synonym: blood coagulation factor activity
has related synonym: serine elastase activity
type: Class
subclass of: endopeptidase activity
subclass of: GO_0008236

obsolete gamma-renin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.
type: Class
subclass of: ObsoleteClass

obsolete acylaminoacyl-peptidase activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.
type: Class
subclass of: ObsoleteClass

obsolete vacuolar carboxypeptidase Y
IAO_0000115: OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.
type: Class
subclass of: ObsoleteClass

obsolete cathepsin G activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.
type: Class
subclass of: ObsoleteClass

obsolete cerevisin activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.
type: Class
subclass of: ObsoleteClass

obsolete chymotrypsin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.
type: Class
subclass of: ObsoleteClass

obsolete dipeptidyl-peptidase IV activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
type: Class
subclass of: ObsoleteClass

obsolete enteropeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.
type: Class
subclass of: ObsoleteClass

obsolete furin activity
IAO_0000115: OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
type: Class
subclass of: ObsoleteClass

obsolete granzyme A activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.
type: Class
subclass of: ObsoleteClass

obsolete granzyme B activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.
type: Class
subclass of: ObsoleteClass

obsolete pancreatic elastase II activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.
type: Class
subclass of: ObsoleteClass

obsolete plasmin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
type: Class
subclass of: ObsoleteClass

obsolete acrosin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.
type: Class
subclass of: ObsoleteClass

obsolete proprotein convertase 1 activity
IAO_0000115: OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
type: Class
subclass of: ObsoleteClass

obsolete proprotein convertase 2 activity
IAO_0000115: OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
type: Class
subclass of: ObsoleteClass

obsolete prolyl oligopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.
type: Class
subclass of: ObsoleteClass

obsolete subtilase activity
IAO_0000115: OBSOLETE. Was not defined before being made obsolete.
type: Class
subclass of: ObsoleteClass

obsolete kexin activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.
type: Class
subclass of: ObsoleteClass

obsolete subtilisin activity
IAO_0000115: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
type: Class
subclass of: ObsoleteClass

obsolete tissue kallikrein activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
replaces: GO_0004279
type: Class
subclass of: ObsoleteClass

obsolete tripeptidyl-peptidase II activity
IAO_0000115: OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.
type: Class
subclass of: ObsoleteClass

obsolete trypsin activity
IAO_0000115: OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.
type: Class
subclass of: ObsoleteClass

threonine-type endopeptidase activity
IAO_0000115: Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
has exact synonym: threonine endopeptidase activity
has related synonym: 26S protease
has related synonym: MCP
has related synonym: alkaline protease
has related synonym: ingensin
has related synonym: large multicatalytic protease
has related synonym: lens neutral proteinase
has related synonym: multicatalytic endopeptidase complex
has related synonym: multicatalytic proteinase
has related synonym: multicatalytic proteinase (complex)
has related synonym: prosome
has related synonym: proteasome endopeptidase complex
has related synonym: tricorn protease
has related synonym: tricorn proteinase
type: Class
subclass of: endopeptidase activity
subclass of: GO_0070003

obsolete proteasome endopeptidase activity
IAO_0000115: OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity.
type: Class
subclass of: ObsoleteClass

enoyl-CoA hydratase activity
IAO_0000115: Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
has exact synonym: (3S)-3-hydroxyacyl-CoA hydro-lyase activity
has exact synonym: 2-enoyl-CoA hydratase activity
has exact synonym: 2-octenoyl coenzyme A hydrase activity
has exact synonym: acyl coenzyme A hydrase activity
has exact synonym: beta-hydroxyacid dehydrase activity
has exact synonym: beta-hydroxyacyl-CoA dehydrase activity
has exact synonym: crotonyl hydrase activity
has exact synonym: enol-CoA hydratase activity
has exact synonym: enoyl coenzyme A hydrase (L)
has exact synonym: enoyl coenzyme A hydratase activity
has exact synonym: enoyl hydrase activity
has exact synonym: hydratase, enoyl coenzyme A
has exact synonym: short chain enoyl coenzyme A hydratase activity
has exact synonym: short-chain enoyl-CoA hydratase activity
has exact synonym: trans-2-enoyl-CoA hydratase activity
has exact synonym: unsaturated acyl-CoA hydratase activity
has related synonym: D-3-hydroxyacyl-CoA dehydratase
has related synonym: ECH
has related synonym: enoyl coenzyme A hydrase (D)
replaces: GO_0016510
type: Class
subclass of: GO_0016836

epoxide hydrolase activity
IAO_0000115: Catalysis of the reaction: an epoxide + H2O = a glycol.
has exact synonym: cytosolic epoxide hydrolase activity
has exact synonym: trans-stilbene oxide hydrolase activity
has related synonym: arene-oxide hydratase activity
has related synonym: aryl epoxide hydrase activity
has related synonym: epoxide hydrase activity
has related synonym: epoxide hydratase activity
has related synonym: sEH
has related synonym: soluble epoxide hydrolase activity
type: Class
subclass of: GO_0016803

estradiol 17-beta-dehydrogenase activity
IAO_0000115: Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
has exact synonym: 17-beta-estradiol dehydrogenase activity
has exact synonym: 17beta,20alpha-hydroxysteroid dehydrogenase activity
has exact synonym: 17beta-estradiol dehydrogenase activity
has exact synonym: 17beta-hydroxysteroid dehydrogenase activity
has exact synonym: estradiol 17beta-dehydrogenase activity
has exact synonym: estradiol dehydrogenase activity
has exact synonym: estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
has exact synonym: estrogen 17-oxidoreductase activity
has related synonym: 17-beta-HSD activity
has related synonym: 17-beta-hydroxysteroid dehydrogenase activity
has related synonym: 17beta-HSD
has related synonym: 20alpha-hydroxysteroid dehydrogenase
type: Class
subclass of: GO_0033764

estrone sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
has exact synonym: 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity
has exact synonym: 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity
has exact synonym: 3'-phosphoadenylylsulfate:oestrone sulfotransferase activity
has exact synonym: estrogen sulphotransferase activity
has exact synonym: estrone sulphotransferase activity
has exact synonym: oestrogen sulphotransferase activity
has related synonym: estrogen sulfotransferase
type: Class
subclass of: GO_0008146

ethanolamine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.
has exact synonym: ATP:ethanolamine O-phosphotransferase activity
has exact synonym: ethanolamine kinase (phosphorylating)
has exact synonym: ethanolamine phosphokinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

ethanolamine-phosphate cytidylyltransferase activity
IAO_0000115: Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
has exact synonym: CTP-phosphoethanolamine cytidylyltransferase activity
has exact synonym: CTP:ethanolamine-phosphate cytidylyltransferase activity
has exact synonym: CTP:phosphoethanolamine cytidylyltransferase activity
has exact synonym: ethanolamine phosphate cytidylyltransferase activity
has exact synonym: phosphoethanolamine cytidylyltransferase activity
has related synonym: ET
has related synonym: phosphorylethanolamine transferase activity
type: Class
subclass of: GO_0070567

ethanolaminephosphotransferase activity
IAO_0000115: Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.
has exact synonym: CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity
has exact synonym: CDPethanolamine diglyceride phosphotransferase activity
has exact synonym: diacylglycerol ethanolaminephosphotransferase activity
has exact synonym: phosphorylethanolamine-glyceride transferase activity
has related synonym: EPT
type: Class
subclass of: GO_0017169

exo-alpha-sialidase activity
IAO_0000115: Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
has exact synonym: N-acylneuraminate glycohydrolase activity
has exact synonym: acetylneuraminidase activity
has exact synonym: acetylneuraminyl hydrolase activity
has exact synonym: alpha-neuraminidase activity
has exact synonym: neuraminidase activity
has exact synonym: sialidase activity
type: Class
subclass of: GO_0016997

exopolyphosphatase activity
IAO_0000115: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.
has exact synonym: Gra-Pase activity
has exact synonym: acid phosphoanhydride phosphohydrolase activity
has exact synonym: exopolypase activity
has exact synonym: polyphosphate phosphohydrolase activity
has related synonym: metaphosphatase activity
type: Class
subclass of: GO_0016462

farnesyl-diphosphate farnesyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
has exact synonym: farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity
has exact synonym: presqualene synthase activity
has exact synonym: presqualene-diphosphate synthase activity
type: Class
subclass of: farnesyltranstransferase activity

farnesyltranstransferase activity
IAO_0000115: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
has exact synonym: geranylgeranyl pyrophosphate synthase activity
has exact synonym: geranylgeranyl pyrophosphate synthetase activity
has exact synonym: geranylgeranyl-PP synthetase activity
has exact synonym: geranylgeranyl-diphosphate synthase activity
has exact synonym: trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity
has related synonym: farnesyltransferase activity
type: Class
subclass of: prenyltransferase activity

fatty acid synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
has exact synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
has exact synonym: fatty-acid synthase activity
type: Class
subclass of: GO_0016747

[acyl-carrier-protein] S-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].
has exact synonym: ACP S-acetyltransferase activity
has exact synonym: ACP acetyltransferase activity
has exact synonym: ACPacetyltransferase activity
has exact synonym: [acyl-carrier protein] S-acetyltransferase activity
has exact synonym: acetyl coenzyme A-acyl-carrier-protein transacylase activity
has exact synonym: acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity
has exact synonym: acyl-carrier-protein S-acetyltransferase activity
has exact synonym: acyl-carrier-protein acetyltransferase activity
has exact synonym: acyl-carrier-proteinacetyltransferase activity
has related synonym: ACAT activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016418

[acyl-carrier-protein] S-malonyltransferase activity
IAO_0000115: Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].
has exact synonym: ACP S-malonyltransferase activity
has exact synonym: MCAT activity
has exact synonym: [acyl-carrier protein] S-malonyltransferase activity
has exact synonym: acyl carrier protein malonyltransferase activity
has exact synonym: acyl carrier proteinmalonyltransferase activity
has exact synonym: acyl-carrier-protein S-malonyltransferase activity
has exact synonym: malonyl coenzyme A-acyl carrier protein transacylase activity
has exact synonym: malonyl-CoA-acyl carrier protein transacylase activity
has exact synonym: malonyl-CoA:ACP transacylase activity
has exact synonym: malonyl-CoA:AcpM transacylase activity
has exact synonym: malonyl-CoA:acyl carrier protein transacylase activity
has exact synonym: malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity
has related synonym: FabD
has related synonym: MAT
has related synonym: malonyl transacylase activity
has related synonym: malonyl transferase activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016419

3-oxoacyl-[acyl-carrier-protein] synthase activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].
has exact synonym: 3-ketoacyl-acyl carrier protein synthase activity
has exact synonym: 3-oxoacyl-ACP synthase activity
has exact synonym: 3-oxoacyl-[acyl-carrier protein] synthase activity
has exact synonym: 3-oxoacyl-acyl-carrier-protein synthase activity
has exact synonym: acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)
has exact synonym: acyl-malonyl acyl carrier protein-condensing enzyme activity
has exact synonym: acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity
has exact synonym: beta-ketoacyl acyl carrier protein synthase activity
has exact synonym: beta-ketoacyl synthetase activity
has exact synonym: beta-ketoacyl-ACP synthase I activity
has exact synonym: beta-ketoacyl-ACP synthetase activity
has exact synonym: beta-ketoacyl-[acyl carrier protein] synthase activity
has exact synonym: beta-ketoacyl-acyl carrier protein synthase activity
has exact synonym: beta-ketoacyl-acyl carrier protein synthetase activity
has exact synonym: beta-ketoacylsynthase activity
has exact synonym: ketoacyl-ACP synthase activity
has related synonym: 3-oxoacyl:ACP synthase I
has related synonym: FabB
has related synonym: FabF1
has related synonym: KAS I activity
has related synonym: KASI
has related synonym: beta-ketoacyl-acyl-carrier-protein synthase I
has related synonym: condensing enzyme activity
has related synonym: fatty acid condensing enzyme activity
type: Class
subclass of: fatty acid synthase activity

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.
has exact synonym: (3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity
has exact synonym: 3-ketoacyl acyl carrier protein reductase activity
has exact synonym: 3-oxoacyl-ACP reductase activity
has exact synonym: 3-oxoacyl-ACPreductase activity
has exact synonym: 3-oxoacyl-[acyl-carrier protein] reductase activity
has exact synonym: 3-oxoacyl-acyl-carrier-protein reductase activity
has exact synonym: NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity
has exact synonym: beta-ketoacyl acyl carrier protein (ACP) reductase activity
has exact synonym: beta-ketoacyl reductase activity
has exact synonym: beta-ketoacyl thioester reductase activity
has exact synonym: beta-ketoacyl-ACP reductase activity
has exact synonym: beta-ketoacyl-acyl carrier protein reductase activity
has exact synonym: beta-ketoacyl-acyl-carrier protein(ACP) reductase activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016616

3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
IAO_0000115: Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.
has exact synonym: (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity
has exact synonym: (3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)
has exact synonym: (3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity
has exact synonym: 3-hydroxypalmitoyl-ACP dehydratase activity
has exact synonym: 3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity
has exact synonym: 3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
has exact synonym: D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
has exact synonym: D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
has exact synonym: beta-hydroxypalmitoyl thioester dehydratase activity
has exact synonym: beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity
has exact synonym: beta-hydroxypalmityl-ACP dehydrase activity
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0019171

enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+.
has exact synonym: NADH-enoyl acyl carrier protein reductase activity
has exact synonym: NADH-specific enoyl-ACP reductase activity
has exact synonym: acyl-acyl-carrier-protein:NAD+ oxidoreductase
has exact synonym: enoyl-ACP reductase (NADH) activity
has exact synonym: enoyl-[acyl-carrier protein] reductase (NADH) activity
has exact synonym: enoyl-acyl-carrier-protein reductase (NADH)
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016628

enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
IAO_0000115: Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.
has exact synonym: NADPH 2-enoyl Co A reductase activity
has exact synonym: acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)
has exact synonym: enoyl acyl-carrier-protein reductase activity
has exact synonym: enoyl-ACP reductase (NADPH, B-specific) activity
has exact synonym: enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity
has exact synonym: enoyl-acyl-carrier-protein reductase (NADPH, B-specific)
has exact synonym: enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)
has exact synonym: reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)
type: Class
subclass of: fatty acid synthase activity
subclass of: GO_0016628

oleoyl-[acyl-carrier-protein] hydrolase activity
IAO_0000115: Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate.
has exact synonym: oleoyl-ACP hydrolase activity
has exact synonym: oleoyl-ACP thioesterase activity
has exact synonym: oleoyl-[acyl-carrier protein] hydrolase activity
has exact synonym: oleoyl-acyl carrier protein thioesterase activity
has related synonym: oleoyl-acyl-carrier-protein hydrolase
type: Class
subclass of: GO_0016297

fatty-acyl-CoA synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
has exact synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
has exact synonym: fatty acyl CoA synthase activity
has related synonym: yeast fatty acid synthase activity
type: Class
subclass of: GO_0016408

ferroxidase activity
IAO_0000115: Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
has exact synonym: Fe(II):oxygen oxidoreductase activity
has exact synonym: ferro:O2 oxidoreductase activity
has exact synonym: ferroxidase, iron II:oxygen oxidoreductase activity
has exact synonym: iron(II): oxygen oxidoreductase activity
has related synonym: caeruloplasmin
has related synonym: ceruloplasmin activity
has related synonym: ferroxidase I
has related synonym: multicopper ferroxidase iron transport mediator activity
type: Class
subclass of: GO_0016724

obsolete multicopper ferroxidase iron transport mediator activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
type: Class
subclass of: ObsoleteClass

ferredoxin-NADP+ reductase activity
IAO_0000115: Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.
has exact synonym: NADP:ferredoxin oxidoreductase activity
has exact synonym: NADPH:ferredoxin oxidoreductase activity
has exact synonym: TPNH-ferredoxin reductase activity
has exact synonym: ferredoxin-NADP oxidoreductase activity
has exact synonym: ferredoxin-NADP reductase activity
has exact synonym: ferredoxin-NADP-oxidoreductase activity
has exact synonym: ferredoxin-TPN reductase activity
has exact synonym: ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity
has exact synonym: ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity
has exact synonym: ferredoxin:NADP+ oxidoreductase activity
has exact synonym: reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity
type: Class
subclass of: GO_0008937

ferrochelatase activity
IAO_0000115: Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX.
has exact synonym: ferro-protoporphyrin chelatase activity
has exact synonym: heme synthase activity
has exact synonym: heme synthetase activity
has exact synonym: iron chelatase activity
has exact synonym: protoheme ferro-lyase (protoporphyrin-forming)
has exact synonym: protoheme ferro-lyase activity
has exact synonym: protoheme ferrolyase activity
type: Class
subclass of: GO_0016829

tetrahydrofolylpolyglutamate synthase activity
IAO_0000115: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
has exact synonym: FPGS activity
has exact synonym: N(10)-formyltetrahydropteroyldiglutamate synthetase activity
has exact synonym: N10-formyltetrahydropteroyldiglutamate synthetase activity
has exact synonym: folate polyglutamate synthetase activity
has exact synonym: folylpoly(gamma-glutamate) synthase activity
has exact synonym: folylpoly-gamma-glutamate synthase activity
has exact synonym: folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity
has exact synonym: folylpolyglutamate synthase activity
has exact synonym: folylpolyglutamate synthetase activity
has exact synonym: folylpolyglutamyl synthetase activity
has exact synonym: formyltetrahydropteroyldiglutamate synthetase activity
has exact synonym: tetrahydrofolate synthase activity
has exact synonym: tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity
has exact synonym: tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)
has exact synonym: tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
type: Class
subclass of: part-of-parent-46901
subclass of: GO_0016881

obsolete formaldehyde dehydrogenase (glutathione) activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+.
type: Class
subclass of: ObsoleteClass

formamidase activity
IAO_0000115: Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+).
has exact synonym: formamide amidohydrolase activity
has exact synonym: formamide hydrolase activity
replaces: GO_0034566
type: Class
subclass of: GO_0016811

formate-tetrahydrofolate ligase activity
IAO_0000115: Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
has exact synonym: 10-formyl-THF synthetase activity
has exact synonym: 10-formyltetrahydrofolate synthetase activity
has exact synonym: formate:tetrahydrofolate ligase (ADP-forming)
has exact synonym: formyltetrahydrofolate synthetase activity
has exact synonym: tetrahydrofolate formylase activity
has exact synonym: tetrahydrofolic formylase activity
type: Class
subclass of: GO_0016879

fructose-2,6-bisphosphate 2-phosphatase activity
IAO_0000115: Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
has exact synonym: D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
has exact synonym: beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
has exact synonym: fructose-2,6-bisphosphatase activity
replaces: GO_0004330
type: Class
subclass of: GO_0050308

fructose-bisphosphate aldolase activity
IAO_0000115: Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
has exact synonym: 1,6-diphosphofructose aldolase activity
has exact synonym: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
has exact synonym: D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity
has exact synonym: diphosphofructose aldolase activity
has exact synonym: fructoaldolase activity
has exact synonym: fructose 1,6-diphosphate aldolase activity
has exact synonym: fructose 1-monophosphate aldolase activity
has exact synonym: fructose 1-phosphate aldolase activity
has exact synonym: fructose diphosphate aldolase activity
has exact synonym: fructose-1,6-bisphosphate triosephosphate-lyase activity
has exact synonym: ketose 1-phosphate aldolase activity
has exact synonym: phosphofructoaldolase activity
has exact synonym: zymohexase activity
has related synonym: SMALDO
has related synonym: aldolase activity
type: Class
subclass of: GO_0016832

fumarate hydratase activity
IAO_0000115: Catalysis of the reaction: (S)-malate = fumarate + H(2)O.
has exact synonym: (S)-malate hydro-lyase (fumarate-forming)
has exact synonym: (S)-malate hydro-lyase activity
has exact synonym: L-malate hydro-lyase activity
has exact synonym: fumarase activity
type: Class
subclass of: GO_0016836

fumarylacetoacetase activity
IAO_0000115: Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
has exact synonym: 4-fumarylacetoacetate fumarylhydrolase activity
has exact synonym: beta-diketonase activity
has exact synonym: fumarylacetoacetate hydrolase activity
type: Class
subclass of: GO_0016823

galactokinase activity
IAO_0000115: Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).
has exact synonym: ATP:D-galactose 1-phosphotransferase activity
has exact synonym: ATP:D-galactose-1-phosphotransferase activity
has exact synonym: galactokinase (phosphorylating)
type: Class
subclass of: GO_0016773
subclass of: GO_0019200

galactosylceramidase activity
IAO_0000115: Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.
has exact synonym: D-galactosyl-N-acylsphingosine galactohydrolase activity
has exact synonym: beta-galactocerebrosidase activity
has exact synonym: beta-galactosylceramidase activity
has exact synonym: ceramide galactosidase activity
has exact synonym: cerebroside beta-galactosidase activity
has exact synonym: cerebroside galactosidase activity
has exact synonym: galactocerebrosidase activity
has exact synonym: galactocerebroside beta-galactosidase activity
has exact synonym: galactocerebroside galactosidase activity
has exact synonym: galactocerebroside-beta-D-galactosidase activity
has exact synonym: galactosylceramide beta-galactosidase activity
has exact synonym: galactosylcerebrosidase activity
has exact synonym: galcerase activity
has exact synonym: lactosylceramidase activity
has related synonym: galactosylceramidase I
has related synonym: lactosylceramidase I
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

geranyltranstransferase activity
IAO_0000115: Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.
has exact synonym: FPP synthetase activity
has exact synonym: farnesyl diphosphate synthetase activity
has exact synonym: farnesyl pyrophosphate synthetase activity
has exact synonym: farnesyl-diphosphate synthase activity
has exact synonym: farnesylpyrophosphate synthetase activity
has exact synonym: geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity
has exact synonym: geranyltransferase activity
has related synonym: geranyl transferase I
type: Class
subclass of: prenyltransferase activity

glucan exo-1,3-beta-glucosidase activity
IAO_0000115: Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.
has exact synonym: beta-1,3-glucan exo-hydrolase activity
has exact synonym: exo (1->3)-beta-glucanase activity
has exact synonym: exo-1,3-beta-D-glucanase activity
has exact synonym: exo-1,3-beta-glucanase activity
has exact synonym: exo-1,3-beta-glucosidase activity
has exact synonym: exo-beta-(1->3)-D-glucanase activity
has exact synonym: exo-beta-(1->3)-glucanohydrolase activity
has exact synonym: exo-beta-1,3-D-glucanase activity
has exact synonym: exo-beta-1,3-glucanase activity
has related synonym: 1,3-beta-glucan glucohydrolase activity
has related synonym: glucan 1,3-beta-glucosidase activity
type: Class
subclass of: GO_0008422

glucan 1,4-alpha-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.
has exact synonym: 1,4-alpha-D-glucan glucohydrolase activity
has exact synonym: amyloglucosidase activity
has exact synonym: exo-1,4-alpha-glucosidase activity
has exact synonym: gamma-1,4-glucan glucohydrolase activity
has exact synonym: gamma-amylase activity
has exact synonym: glucoamylase activity
has exact synonym: glucose amylase activity
has related synonym: lysosomal alpha-glucosidase activity
type: Class
subclass of: GO_0015926

glucokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
has exact synonym: ATP:D-glucose 6-phosphotransferase activity
has exact synonym: glucokinase (phosphorylating)
has exact synonym: glucose kinase activity
type: Class
subclass of: part-of-parent-51156
subclass of: hexokinase activity

gluconolactonase activity
IAO_0000115: Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
has exact synonym: D-glucono-1,5-lactone lactonohydrolase activity
has exact synonym: aldonolactonase activity
has exact synonym: glucono-delta-lactonase activity
has exact synonym: gulonolactonase activity
has related synonym: lactonase activity
type: Class
subclass of: GO_0052689

glucosamine-6-phosphate deaminase activity
IAO_0000115: Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+).
has exact synonym: 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
has exact synonym: GlcN6P deaminase activity
has exact synonym: aminodeoxyglucosephosphate isomerase activity
has exact synonym: glucosamine phosphate deaminase activity
has exact synonym: glucosamine-6-phosphate isomerase activity
has exact synonym: phosphoglucosamine isomerase activity
has exact synonym: phosphoglucosaminisomerase activity
has related synonym: glucosaminephosphate isomerase
type: Class
subclass of: GO_0016861
subclass of: GO_0019239

glucosamine 6-phosphate N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+).
has exact synonym: D-glucosamine-6-P N-acetyltransferase activity
has exact synonym: N-acetylglucosamine-6-phosphate synthase activity
has exact synonym: acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity
has exact synonym: aminodeoxyglucosephosphate acetyltransferase activity
has exact synonym: glucosamine 6-phosphate acetylase activity
has exact synonym: glucosamine-6-phosphate acetylase activity
has exact synonym: glucosamine-phosphate N-acetyltransferase activity
has exact synonym: phosphoglucosamine N-acetylase activity
has exact synonym: phosphoglucosamine acetylase activity
has exact synonym: phosphoglucosamine transacetylase activity
type: Class
subclass of: GO_0008080

glucose dehydrogenase activity
IAO_0000115: Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor.
has exact synonym: D-glucose:(acceptor) 1-oxidoreductase
has exact synonym: D-glucose:acceptor 1-oxidoreductase
has exact synonym: glucose dehydrogenase (acceptor) activity
has exact synonym: glucose dehydrogenase (decarboxylating)
has related synonym: glucose dehydrogenase (Aspergillus) activity
replaces: GO_0008708
type: Class
subclass of: GO_0016614

glucose-6-phosphate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
has exact synonym: 6-phosphoglucose dehydrogenase activity
has exact synonym: D-glucose 6-phosphate dehydrogenase activity
has exact synonym: D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity
has exact synonym: G6PD activity
has exact synonym: G6PDH
has exact synonym: NADP-dependent glucose 6-phosphate dehydrogenase activity
has exact synonym: NADP-glucose-6-phosphate dehydrogenase activity
has exact synonym: glucose 6-phosphate dehydrogenase (NADP) activity
has exact synonym: glucose-6-phosphate 1-dehydrogenase activity
has related synonym: 6-phosphoglucose dehydrogenas
has related synonym: Entner-doudoroff enzyme
has related synonym: GDH
has related synonym: Zwischenferment
has related synonym: zwischenferment
type: Class
subclass of: GO_0016616

glucose-6-phosphatase activity
IAO_0000115: Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.
has exact synonym: D-glucose-6-phosphate phosphohydrolase activity
has exact synonym: glucose 6-phosphate phosphatase activity
type: Class
subclass of: GO_0050309

glucose-6-phosphate isomerase activity
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.
has exact synonym: D-glucose-6-phosphate aldose-ketose-isomerase activity
has exact synonym: D-glucose-6-phosphate ketol-isomerase activity
has exact synonym: glucose phosphate isomerase activity
has exact synonym: hexose phosphate isomerase activity
has exact synonym: phosphoglucoisomerase activity
has exact synonym: phosphoglucose isomerase activity
has related synonym: hexose monophosphate isomerase activity
has related synonym: hexosephosphate isomerase activity
has related synonym: oxoisomerase activity
has related synonym: phosphohexoisomerase activity
has related synonym: phosphohexomutase activity
has related synonym: phosphohexose isomerase activity
has related synonym: phosphosaccharomutase activity
type: Class
subclass of: GO_0016861

glucosylceramidase activity
IAO_0000115: Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
has exact synonym: D-glucosyl-N-acylsphingosine glucohydrolase activity
has exact synonym: GlcCer-beta-glucosidase activity
has exact synonym: acid beta-glucosidase activity
has exact synonym: beta-D-glucocerebrosidase activity
has exact synonym: beta-glucocerebrosidase activity
has exact synonym: beta-glucosylceramidase activity
has exact synonym: ceramide glucosidase activity
has exact synonym: glucocerebrosidase activity
has exact synonym: glucosphingosine glucosylhydrolase activity
has exact synonym: glucosylcerebrosidase activity
has exact synonym: glucosylsphingosine beta-D-glucosidase activity
has exact synonym: glucosylsphingosine beta-glucosidase activity
has exact synonym: psychosine hydrolase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

glutamate 5-kinase activity
IAO_0000115: Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
has exact synonym: ATP-L-glutamate 5-phosphotransferase activity
has exact synonym: ATP:L-glutamate 5-phosphotransferase activity
has exact synonym: ATP:gamma-L-glutamate phosphotransferase activity
has exact synonym: gamma-glutamate kinase activity
has exact synonym: gamma-glutamyl kinase activity
has exact synonym: glutamate kinase activity
type: Class
subclass of: GO_0016774
subclass of: GO_0019202

glutamate-5-semialdehyde dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
has exact synonym: L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
has exact synonym: beta-glutamylphosphate reductase activity
has exact synonym: gamma-glutamyl phosphate reductase activity
has exact synonym: gamma-glutamylphosphate reductase activity
has exact synonym: glutamate semialdehyde dehydrogenase activity
has exact synonym: glutamate-gamma-semialdehyde dehydrogenase activity
has exact synonym: glutamate-phosphate reductase activity
has exact synonym: glutamyl-gamma-semialdehyde dehydrogenase activity
has exact synonym: glutamylphosphate reductase activity
replaces: GO_0001513
type: Class
subclass of: GO_0016620

glutamate decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
has exact synonym: L-aspartate-alpha-decarboxylase activity
has exact synonym: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
has exact synonym: L-glutamate 1-carboxy-lyase activity
has exact synonym: L-glutamate alpha-decarboxylase activity
has exact synonym: L-glutamic acid decarboxylase activity
has exact synonym: L-glutamic decarboxylase activity
has exact synonym: cysteic acid decarboxylase activity
has exact synonym: gamma-glutamate decarboxylase activity
has related synonym: aspartic alpha-decarboxylase
type: Class
subclass of: GO_0016831

glutamate dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
has exact synonym: L-glutamate:NAD+ oxidoreductase (deaminating)
has exact synonym: NAD-dependent glutamate dehydrogenase activity
has exact synonym: NAD-dependent glutamic dehydrogenase activity
has exact synonym: NAD-glutamate dehydrogenase activity
has exact synonym: NAD-linked glutamate dehydrogenase activity
has exact synonym: NAD-linked glutamic dehydrogenase activity
has exact synonym: NAD-specific glutamate dehydrogenase activity
has exact synonym: NAD-specific glutamic dehydrogenase activity
has exact synonym: NAD:glutamate oxidoreductase activity
has exact synonym: NADH-linked glutamate dehydrogenase activity
has exact synonym: glutamate dehydrogenase (NAD)
has exact synonym: glutamate oxidoreductase activity
has related synonym: L-glutamate dehydrogenase
has related synonym: glutamic acid dehydrogenase
has related synonym: glutamic dehydrogenase activity
type: Class
subclass of: glutamate dehydrogenase [NAD(P)+] activity

glutamate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
has exact synonym: L-glutamate:NAD(P)+ oxidoreductase (deaminating)
has related synonym: glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
has related synonym: glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
has related synonym: glutamic dehydrogenase activity
type: Class
subclass of: GO_0016639

glutamate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
has exact synonym: L-glutamate:NADP+ oxidoreductase (deaminating)
has exact synonym: L-glutamic acid dehydrogenase activity
has exact synonym: NAD(P)-glutamate dehydrogenase activity
has exact synonym: NAD(P)H-dependent glutamate dehydrogenase activity
has exact synonym: dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
has related synonym: L-glutamate dehydrogenase
has related synonym: glutamic acid dehydrogenase
has related synonym: glutamic dehydrogenase activity
type: Class
subclass of: glutamate dehydrogenase [NAD(P)+] activity

glutamate synthase (NADPH) activity
IAO_0000115: Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.
has exact synonym: L-glutamate:NADP+ oxidoreductase (transaminating)
has exact synonym: L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity
has exact synonym: NADPH GOGAT
has exact synonym: NADPH-dependent glutamate synthase activity
has exact synonym: NADPH-glutamate synthase activity
has exact synonym: NADPH-linked glutamate synthase
has exact synonym: glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity
has exact synonym: glutamate synthetase (NADP) activity
has exact synonym: glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity
has exact synonym: glutamine-ketoglutaric aminotransferase activity
has related synonym: GOGAT activity
has related synonym: L-glutamate synthase activity
has related synonym: L-glutamate synthetase activity
type: Class
subclass of: GO_0045181

glutamate-ammonia ligase activity
IAO_0000115: Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
has exact synonym: L-glutamate:ammonia ligase (ADP-forming)
has exact synonym: L-glutamine synthetase activity
has exact synonym: glutamine synthetase activity
has exact synonym: glutamylhydroxamic synthetase activity
type: Class
subclass of: GO_0016211

glutamate-cysteine ligase activity
IAO_0000115: Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
has exact synonym: L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
has exact synonym: gamma-glutamyl-L-cysteine synthetase activity
has exact synonym: gamma-glutamylcysteine synthetase activity
has exact synonym: gamma-glutamylcysteinyl synthetase activity
type: Class
subclass of: GO_0016881

glutamate N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.
has exact synonym: 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has exact synonym: N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has exact synonym: acetylglutamate synthetase activity
has exact synonym: acetylglutamate-acetylornithine transacetylase activity
has exact synonym: acetylglutamic synthetase activity
has exact synonym: acetylglutamic-acetylornithine transacetylase activity
has exact synonym: acetylornithine glutamate acetyltransferase activity
has exact synonym: alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity
has exact synonym: glutamate acetyltransferase activity
has exact synonym: ornithine acetyltransferase activity
has exact synonym: ornithine transacetylase activity
has related synonym: N-acetyl-L-glutamate synthetase activity
has related synonym: N-acetylglutamate synthase activity
has related synonym: N-acetylglutamate synthetase activity
has related synonym: acetylornithinase activity
type: Class
subclass of: GO_0008080

glutaminase activity
IAO_0000115: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
has exact synonym: L-glutaminase activity
has exact synonym: L-glutamine amidohydrolase activity
has exact synonym: glutamine aminohydrolase activity
has related synonym: glutaminase I
type: Class
subclass of: GO_0016811

glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAO_0000115: Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.
has exact synonym: D-fructose-6-phosphate amidotransferase activity
has exact synonym: GlcN6P synthase activity
has exact synonym: L-glutamine-D-fructose-6-phosphate amidotransferase activity
has exact synonym: L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
has exact synonym: glucosamine 6-phosphate synthase activity
has exact synonym: glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity
has exact synonym: glucosamine-6-phosphate isomerase (glutamine-forming) activity
has exact synonym: glucosamine-6-phosphate synthase activity
has exact synonym: hexosephosphate aminotransferase activity
has related synonym: glucosaminephosphate isomerase
type: Class
subclass of: GO_0070548

glutaryl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.
has exact synonym: glutaryl coenzyme A dehydrogenase activity
has exact synonym: glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)
has exact synonym: glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)
type: Class
subclass of: acyl-CoA dehydrogenase activity

glutathione-disulfide reductase activity
IAO_0000115: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
has exact synonym: GSH reductase activity
has exact synonym: GSSG reductase activity
has exact synonym: NADPH-GSSG reductase activity
has exact synonym: NADPH-glutathione reductase activity
has exact synonym: NADPH:oxidized-glutathione oxidoreductase activity
has exact synonym: glutathione S-reductase activity
has exact synonym: glutathione reductase (NADPH) activity
has exact synonym: glutathione reductase activity
has exact synonym: glutathione-disulphide reductase activity
has exact synonym: glutathione:NADP+ oxidoreductase activity
has related synonym: oxidized glutathione reduction
type: Class
subclass of: GO_0015038
subclass of: GO_0016209
subclass of: GO_0016668

glutathione synthase activity
IAO_0000115: Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
has exact synonym: GSH synthetase activity
has exact synonym: gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
has exact synonym: glutathione synthetase activity
type: Class
subclass of: part-of-parent-6750
subclass of: GO_0016881

glutathione transferase activity
IAO_0000115: Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
has exact synonym: RX:glutathione R-transferase activity
has exact synonym: S-(hydroxyalkyl)glutathione lyase activity
has exact synonym: glutathione S-alkyl transferase activity
has exact synonym: glutathione S-alkyltransferase activity
has exact synonym: glutathione S-aralkyltransferase activity
has exact synonym: glutathione S-aryltransferase activity
has exact synonym: glutathione S-transferase activity
has exact synonym: glutathione conjugation reaction
type: Class
subclass of: GO_0016765

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IAO_0000115: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
has exact synonym: 3-phosphoglyceraldehyde dehydrogenase activity
has exact synonym: D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
has exact synonym: GAPDH activity
has exact synonym: NAD-dependent glyceraldehyde phosphate dehydrogenase activity
has exact synonym: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity
has exact synonym: NADH-glyceraldehyde phosphate dehydrogenase activity
has exact synonym: dehydrogenase, glyceraldehyde phosphate
has exact synonym: glyceraldehyde phosphate dehydrogenase (NAD)
has exact synonym: glyceraldehyde-3-P-dehydrogenase activity
has exact synonym: phosphoglyceraldehyde dehydrogenase activity
has related synonym: triosephosphate dehydrogenase activity
type: Class
subclass of: GO_0043891

glycerol-3-phosphate O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
has exact synonym: 3-glycerophosphate acyltransferase activity
has exact synonym: ACP:sn-glycerol-3-phosphate acyltransferase activity
has exact synonym: acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity
has exact synonym: alpha-glycerophosphate acyltransferase activity
has exact synonym: glycerol 3-phosphate acyltransferase activity
has exact synonym: glycerol phosphate acyltransferase activity
has exact synonym: glycerol phosphate transacylase activity
has exact synonym: glycerophosphate acyltransferase activity
has exact synonym: glycerophosphate transacylase activity
has exact synonym: sn-glycerol 3-phosphate acyltransferase activity
has exact synonym: sn-glycerol-3-phosphate acyltransferase activity
type: Class
subclass of: GO_0008374

glycerol-3-phosphate dehydrogenase [NAD+] activity
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+.
has exact synonym: NAD-L-glycerol-3-phosphate dehydrogenase activity
has exact synonym: NAD-alpha-glycerophosphate dehydrogenase activity
has exact synonym: NAD-dependent glycerol phosphate dehydrogenase activity
has exact synonym: NAD-dependent glycerol-3-phosphate dehydrogenase activity
has exact synonym: NAD-linked glycerol 3-phosphate dehydrogenase activity
has exact synonym: alpha-glycerol phosphate dehydrogenase (NAD) activity
has exact synonym: alpha-glycerophosphate dehydrogenase (NAD) activity
has exact synonym: glycerol phosphate dehydrogenase (NAD) activity
has exact synonym: glycerol-3-phosphate dehydrogenase (NAD) activity
has exact synonym: glycerophosphate dehydrogenase (NAD) activity
has related synonym: L-alpha-glycerol phosphate dehydrogenase activity
has related synonym: L-alpha-glycerophosphate dehydrogenase activity
has related synonym: L-glycerol phosphate dehydrogenase activity
has related synonym: L-glycerophosphate dehydrogenase activity
has related synonym: NADH-dihydroxyacetone phosphate reductase activity
has related synonym: glycerol 1-phosphate dehydrogenase activity
has related synonym: hydroglycerophosphate dehydrogenase activity
type: Class
subclass of: GO_0047952

glycerol-3-phosphate dehydrogenase (quinone) activity
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
has exact synonym: FAD-dependent glycerol-3-phosphate dehydrogenase
has exact synonym: L-glycerophosphate dehydrogenase activity
has exact synonym: flavin-linked glycerol-3-phosphate dehydrogenase
has exact synonym: glycerol-3-phosphate CoQ reductase
has exact synonym: glycerophosphate dehydrogenase activity
has exact synonym: sn-glycerol-3-phosphate dehydrogenase activity
has exact synonym: sn-glycerol-3-phosphate:quinone oxidoreductase activity
type: Class
subclass of: GO_0016901

glycerol-3-phosphate oxidase activity
IAO_0000115: Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2).
has exact synonym: L-alpha-glycerol-3-phosphate oxidase activity
has exact synonym: L-alpha-glycerophosphate oxidase activity
has exact synonym: alpha-glycerophosphate oxidase activity
has exact synonym: glycerol phosphate oxidase activity
has exact synonym: glycerol-1-phosphate oxidase activity
has exact synonym: sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity
type: Class
subclass of: GO_0016899

glycerol kinase activity
IAO_0000115: Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).
has exact synonym: ATP:glycerol 3-phosphotransferase activity
has exact synonym: ATP:glycerol-3-phosphotransferase activity
has exact synonym: glyceric kinase activity
has exact synonym: glycerokinase activity
has exact synonym: glycerol kinase (phosphorylating)
has related synonym: GK
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

glycerone kinase activity
IAO_0000115: Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).
has exact synonym: ATP:glycerone phosphotransferase activity
has exact synonym: acetol kinase (phosphorylating)
has exact synonym: acetol kinase activity
has exact synonym: dihydroxyacetone kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

glycine hydroxymethyltransferase activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
has exact synonym: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity
has exact synonym: L-serine hydroxymethyltransferase activity
has exact synonym: allothreonine aldolase activity
has exact synonym: serine aldolase activity
has exact synonym: serine hydroxymethylase activity
has exact synonym: serine hydroxymethyltransferase activity
has exact synonym: serine transhydroxymethylase activity
type: Class
subclass of: GO_0016742

glycogen (starch) synthase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).
has exact synonym: UDP-glucose-glycogen glucosyltransferase activity
has exact synonym: UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity
has exact synonym: UDP-glycogen synthase activity
has exact synonym: UDPG-glycogen synthetase activity
has exact synonym: UDPG-glycogen transglucosylase activity
has exact synonym: UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity
has exact synonym: glycogen (starch) synthetase activity
has exact synonym: uridine diphosphoglucose-glycogen glucosyltransferase activity
type: Class
subclass of: GO_0035251

obsolete glycine cleavage system
IAO_0000115: OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating).
type: Class
subclass of: ObsoleteClass

glycine dehydrogenase (decarboxylating) activity
IAO_0000115: Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.
has exact synonym: glycine decarboxylase activity
has exact synonym: glycine-cleavage complex P-protein activity
has exact synonym: glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
has exact synonym: glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
has related synonym: P-protein
has related synonym: glycine cleavage system P-protein activity
has related synonym: glycine-cleavage complex
has related synonym: protein P1
type: Class
subclass of: GO_0016642

glycolipid mannosyltransferase activity
IAO_0000115: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.
has exact synonym: glycolipid mannosyl transferase activity
replaces: GO_0004580
type: Class
subclass of: mannosyltransferase activity

GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
has exact synonym: GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
has exact synonym: GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
has exact synonym: GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
has exact synonym: glycolipid 2-alpha-mannosyltransferase activity
has exact synonym: guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
has exact synonym: oligosaccharide-lipid mannosyltransferase activity
type: Class
subclass of: alpha-1,2-mannosyltransferase activity
subclass of: glycolipid mannosyltransferase activity

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.
has exact synonym: GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity
has exact synonym: GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity
has exact synonym: glycolipid 3-alpha-mannosyltransferase activity
has exact synonym: guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity
has exact synonym: mannosyltransferase II activity
has related synonym: GDP-mannose-oligosaccharide-lipid mannosyltransferase II
type: Class
subclass of: glycolipid mannosyltransferase activity

glycylpeptide N-tetradecanoyltransferase activity
IAO_0000115: Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
has exact synonym: N-myristoyltransferase activity
has exact synonym: myristoyl-CoA-protein N-myristoyltransferase activity
has exact synonym: myristoyl-coenzyme A:protein N-myristoyl transferase activity
has exact synonym: peptide N-myristoyltransferase activity
has exact synonym: peptide N-tetradecanoyltransferase activity
has exact synonym: protein N-myristoyltransferase activity
has exact synonym: tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity
has related synonym: myristoylating enzymes
replaces: GO_0019106
type: Class
subclass of: GO_0016410
subclass of: GO_0019107

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
has exact synonym: A-transferase activity
has exact synonym: UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
has exact synonym: alpha-3-N-acetylgalactosaminyltransferase activity
has exact synonym: blood-group substance A-dependent acetylgalactosaminyltransferase activity
has exact synonym: blood-group substance alpha-acetyltransferase activity
has exact synonym: fucosylgalactose acetylgalactosaminyltransferase activity
has exact synonym: fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity
has exact synonym: fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity
has exact synonym: histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)
has related synonym: A transferase activity
has related synonym: histo-blood group A acetylgalactosaminyltransferase activity
has related synonym: histo-blood group A transferase activity
type: Class
subclass of: GO_0008376
subclass of: GO_0140103

fucosylgalactoside 3-alpha-galactosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
has exact synonym: UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity
has exact synonym: UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity
has exact synonym: fucosylglycoprotein 3-alpha-galactosyltransferase activity
has exact synonym: glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity
has exact synonym: histo-blood substance B-dependent galactosyltransferase activity
has related synonym: B transferase activity
has related synonym: [blood group substance] alpha-galactosyltransferase activity
has related synonym: blood-group substance B-dependent galactosyltransferase activity
has related synonym: blood-group substance beta-dependent galactosyltransferase activity
has related synonym: histo-blood group B transferase activity
has related synonym: histo-blood substance beta-dependent galactosyltransferase activity
type: Class
subclass of: GO_0035250

guanosine-diphosphatase activity
IAO_0000115: Catalysis of the reaction: GDP + H2O = GMP + phosphate.
has exact synonym: GDP phosphohydrolase activity
has exact synonym: GDPase activity
has exact synonym: guanosine 5'-diphosphatase activity
has exact synonym: guanosine diphosphatase activity
type: Class
subclass of: GO_0017110

guanylate cyclase activity
IAO_0000115: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
has exact synonym: GTP diphosphate-lyase (cyclizing) activity
has exact synonym: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
has exact synonym: guanyl cyclase activity
has exact synonym: guanylyl cyclase activity
has related synonym: receptor guanylate cyclase activity
type: Class
subclass of: part-of-parent-6182
subclass of: GO_0009975
subclass of: GO_0016849

obsolete membrane-associated guanylate kinase
IAO_0000115: OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane.
type: Class
subclass of: ObsoleteClass

guanylate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + GMP = ADP + GDP.
has exact synonym: 5'-GMP kinase activity
has exact synonym: ATP:(d)GMP phosphotransferase activity
has exact synonym: ATP:GMP phosphotransferase activity
has exact synonym: GMP kinase activity
has exact synonym: guanosine monophosphate kinase activity
has related synonym: deoxyguanylate kinase activity
has related synonym: membrane-associated guanylate kinase
type: Class
subclass of: part-of-parent-46037
subclass of: part-of-parent-46710
subclass of: GO_0050145

helicase activity
IAO_0000115: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
has exact synonym: ATP-dependent helicase activity
replaces: GO_0008026
type: Class
subclass of: GO_0016887

heme oxygenase (decyclizing) activity
IAO_0000115: Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O.
has exact synonym: haem oxidase activity
has exact synonym: haem oxygenase (decyclizing) activity
has exact synonym: haem oxygenase activity
has exact synonym: heme oxidase activity
has exact synonym: heme oxygenase activity
has exact synonym: heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
has related synonym: ORP33 proteins
type: Class
subclass of: GO_0016705

heparan sulfate 2-O-sulfotransferase activity
IAO_0000115: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.
has exact synonym: heparan-sulfate 2-O-sulphotransferase activity
has related synonym: heparin 2-sulfotransferase activity
has related synonym: heparin-sulphate 2-sulphotransferase activity
type: Class
subclass of: GO_0034483

hexaprenyldihydroxybenzoate methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.
has exact synonym: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity
has exact synonym: DHHB methyltransferase activity
has exact synonym: DHHB-Mt activity
has exact synonym: S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity
has exact synonym: dihydroxyhexaprenylbenzoate methyltransferase activity
type: Class
subclass of: GO_0010420

hexokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
has exact synonym: ATP-dependent hexokinase activity
has exact synonym: ATP:D-hexose 6-phosphotransferase activity
has exact synonym: glucose ATP phosphotransferase activity
has exact synonym: hexokinase (phosphorylating)
has exact synonym: hexokinase type IV glucokinase activity
has related synonym: hexokinase D
has related synonym: hexokinase type I activity
has related synonym: hexokinase type II activity
has related synonym: hexokinase type III activity
has related synonym: hexokinase type IV
has related synonym: hexokinase type IV (glucokinase) activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019200

histidine ammonia-lyase activity
IAO_0000115: Catalysis of the reaction: L-histidine = urocanate + NH3.
has exact synonym: L-histidine ammonia-lyase (urocanate-forming)
has exact synonym: L-histidine ammonia-lyase activity
has related synonym: histidase activity
has related synonym: histidinase activity
has related synonym: histidine alpha-deaminase activity
type: Class
subclass of: GO_0016841

histidine decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-histidine = histamine + CO2.
has exact synonym: L-histidine carboxy-lyase (histamine-forming)
has exact synonym: L-histidine carboxy-lyase activity
has exact synonym: L-histidine decarboxylase activity
type: Class
subclass of: GO_0016831

histidinol dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+.
type: Class
subclass of: GO_0016616

histidinol-phosphate transaminase activity
IAO_0000115: Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
has exact synonym: IAP transaminase activity
has exact synonym: L-histidinol phosphate aminotransferase activity
has exact synonym: L-histidinol-phosphate:2-oxoglutarate aminotransferase activity
has exact synonym: glutamic-imidazoleacetol phosphate transaminase activity
has exact synonym: histidine:imidazoleacetol phosphate transaminase activity
has exact synonym: histidinol phosphate aminotransferase activity
has exact synonym: histidinol-phosphate aminotransferase activity
has exact synonym: imidazole acetol-phosphate transaminase activity
has exact synonym: imidazoleacetol phosphate transaminase activity
has exact synonym: imidazolylacetolphosphate aminotransferase activity
has exact synonym: imidazolylacetolphosphate transaminase activity
type: Class
subclass of: GO_0008483

histidinol-phosphatase activity
IAO_0000115: Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
has exact synonym: HPpase activity
has exact synonym: L-histidinol phosphate phosphatase activity
has exact synonym: L-histidinol-phosphate phosphohydrolase activity
has exact synonym: histidinol phosphate phosphatase activity
has exact synonym: histidinolphosphatase activity
has exact synonym: histidinolphosphate phosphatase activity
type: Class
subclass of: GO_0016791

histone acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
has exact synonym: acetyl-CoA:histone acetyltransferase activity
has exact synonym: histone acetokinase activity
has exact synonym: histone acetylase activity
has exact synonym: histone lysine acetyltransferase activity
has exact synonym: histone transacetylase activity
has related synonym: H2A/H2B histone acetyltransferase activity
has related synonym: H3/H4 histone acetyltransferase activity
has related synonym: H4/H2 histone acetyltransferase activity
has related synonym: H4/H2A acetyltransferase activity
has related synonym: nucleosome-histone acetyltransferase activity
replaces: GO_0004403
replaces: GO_0004404
replaces: GO_0004405
replaces: GO_0004406
replaces: GO_0043166
replaces: GO_0046971
type: Class
subclass of: part-of-parent-16573
subclass of: GO_0061733

histone deacetylase activity
IAO_0000115: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
type: Class
subclass of: part-of-parent-16575
subclass of: GO_0016811
subclass of: GO_0033558

holocytochrome-c synthase activity
IAO_0000115: Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.
has exact synonym: cytochrome c heme-lyase activity
has exact synonym: holocytochrome c synthetase activity
has exact synonym: holocytochrome-c apocytochrome-c-lyase (heme-forming)
has exact synonym: holocytochrome-c apocytochrome-c-lyase activity
has related synonym: cytochrome c synthase activity
type: Class
subclass of: GO_0016846

homoaconitate hydratase activity
IAO_0000115: Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O.
has exact synonym: 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity
has exact synonym: HACN activity
has exact synonym: cis-homoaconitase activity
has exact synonym: homoaconitase activity
has related synonym: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]
has related synonym: Lys4
has related synonym: LysF
type: Class
subclass of: GO_0016836

homocitrate synthase activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
has exact synonym: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity
has exact synonym: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
has exact synonym: acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
has exact synonym: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity
has exact synonym: homocitrate synthetase activity
type: Class
subclass of: GO_0046912

homogentisate 1,2-dioxygenase activity
IAO_0000115: Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
has exact synonym: homogentisate dioxygenase activity
has exact synonym: homogentisate oxidase activity
has exact synonym: homogentisate oxygenase activity
has exact synonym: homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
has exact synonym: homogentisic acid oxidase activity
has exact synonym: homogentisic acid oxygenase activity
has exact synonym: homogentisic oxygenase activity
has exact synonym: homogentisicase activity
type: Class
subclass of: GO_0016702

homoserine dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.
type: Class
subclass of: GO_0016616

homoserine kinase activity
IAO_0000115: Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).
has exact synonym: ATP:L-homoserine O-phosphotransferase activity
has exact synonym: homoserine kinase (phosphorylating)
has related synonym: HSK
type: Class
subclass of: GO_0016773
subclass of: GO_0019202

homoserine O-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.
has exact synonym: L-homoserine O-acetyltransferase activity
has exact synonym: acetyl-CoA:L-homoserine O-acetyltransferase activity
has exact synonym: homoserine O-trans-acetylase activity
has exact synonym: homoserine acetyltransferase activity
has exact synonym: homoserine-O-transacetylase activity
has related synonym: homoserine transacetylase activity
type: Class
subclass of: GO_0016413

hyalurononglucosaminidase activity
IAO_0000115: Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
has exact synonym: chondroitinase I activity
has exact synonym: hyaluronate 4-glycanohydrolase activity
has exact synonym: hyaluronoglucosaminidase activity
has exact synonym: hyaluronoglucosidase activity
has related synonym: chondroitinase activity
has related synonym: hyaluronidase activity
type: Class
subclass of: GO_0015929

hydroxyacylglutathione hydrolase activity
IAO_0000115: Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
has exact synonym: S-(2-hydroxyacyl)glutathione hydrolase activity
has exact synonym: S-2-hydroxylacylglutathione hydrolase activity
has exact synonym: acetoacetylglutathione hydrolase activity
has exact synonym: glyoxalase II activity
type: Class
subclass of: GO_0016790

hydroxyethylthiazole kinase activity
IAO_0000115: Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+).
has exact synonym: 4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity
has exact synonym: ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity
has exact synonym: hydroxyethylthiazole kinase (phosphorylating)
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

hydroxymethylbilane synthase activity
IAO_0000115: Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
has exact synonym: (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
has exact synonym: (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
has exact synonym: HMB-synthase activity
has exact synonym: porphobilinogen ammonia-lyase (polymerizing)
has exact synonym: porphobilinogen deaminase activity
has exact synonym: porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
has exact synonym: pre-uroporphyrinogen synthase activity
has exact synonym: uroporphyrinogen synthase activity
has exact synonym: uroporphyrinogen synthetase activity
has related synonym: uroporphyrinogen I synthase activity
has related synonym: uroporphyrinogen I synthetase activity
type: Class
subclass of: GO_0016765

hydroxymethylglutaryl-CoA lyase activity
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity
has exact synonym: 3-hydroxy-3-methylglutarate-CoA lyase activity
has exact synonym: 3-hydroxy-3-methylglutaryl coenzyme A lyase activity
has exact synonym: 3-hydroxy-3-methylglutaryl-CoA lyase activity
has exact synonym: HMG-CoA lyase activity
has exact synonym: hydroxymethylglutaryl coenzyme A lyase activity
has related synonym: 3-hydroxy-3-methylglutaryl CoA cleaving enzyme
has related synonym: hydroxymethylglutaryl coenzyme A-cleaving enzyme
type: Class
subclass of: GO_0016833

hydroxymethylglutaryl-CoA reductase (NADPH) activity
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
has related synonym: 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
has related synonym: HMG-CoA reductase activity
type: Class
subclass of: GO_0016616

hydroxymethylglutaryl-CoA synthase activity
IAO_0000115: Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
has exact synonym: (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
has exact synonym: 3-hydroxy-3-methylglutaryl CoA synthetase activity
has exact synonym: 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
has exact synonym: 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
has exact synonym: 3-hydroxy-3-methylglutaryl-CoA synthase activity
has exact synonym: 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
has exact synonym: HMG-CoA synthase activity
has exact synonym: acetoacetyl coenzyme A transacetase activity
has exact synonym: acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has exact synonym: beta-hydroxy-beta-methylglutaryl-CoA synthase activity
has exact synonym: hydroxymethylglutaryl coenzyme A synthase activity
has exact synonym: hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
has related synonym: hydroxymethylglutaryl coenzyme A-condensing enzyme
type: Class
subclass of: GO_0046912

hypoxanthine phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
has exact synonym: HGPRTase activity
has exact synonym: IMP diphosphorylase activity
has exact synonym: IMP pyrophosphorylase activity
has exact synonym: IMP-GMP pyrophosphorylase activity
has exact synonym: IMP:diphosphate phospho-D-ribosyltransferase activity
has exact synonym: inosinate pyrophosphorylase activity
has exact synonym: inosine 5'-phosphate pyrophosphorylase activity
has exact synonym: inosinic acid pyrophosphorylase activity
has exact synonym: inosinic pyrophosphorylase activity
has related synonym: 6-hydroxypurine phosphoribosyltransferase activity
has related synonym: 6-mercaptopurine phosphoribosyltransferase activity
has related synonym: HPRT
has related synonym: Transphosphoribosidase activity
has related synonym: guanine-hypoxanthine phosphoribosyltransferase activity
has related synonym: hypoxanthine-guanine phosphoribosyltransferase activity
has related synonym: purine-6-thiol phosphoribosyltransferase activity
type: Class
subclass of: GO_0106130

iduronate-2-sulfatase activity
IAO_0000115: Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.
has exact synonym: 2-sulfo-L-iduronate 2-sulfatase activity
has exact synonym: L-iduronate 2-sulfate sulfatase activity
has exact synonym: L-iduronate-2-sulfate 2-sulfohydrolase activity
has exact synonym: L-idurono sulfate sulfatase activity
has exact synonym: L-iduronosulfatase activity
has exact synonym: iduronate sulfatase activity
has exact synonym: iduronate sulfate sulfatase activity
has exact synonym: iduronate-2-sulfate sulfatase activity
has exact synonym: iduronate-2-sulphatase activity
has exact synonym: iduronide-2-sulfate sulfatase activity
has exact synonym: idurono-2-sulfatase activity
has exact synonym: sulfo-L-iduronate sulfatase activity
has exact synonym: sulfoiduronate sulfohydrolase activity
has related synonym: chondroitinsulfatase
type: Class
subclass of: GO_0008484

imidazoleglycerol-phosphate dehydratase activity
IAO_0000115: Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
has exact synonym: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity
has exact synonym: IGP dehydratase activity
has exact synonym: imidazoleglycerol phosphate dehydratase activity
has related synonym: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]
type: Class
subclass of: GO_0016836

indole-3-glycerol-phosphate synthase activity
IAO_0000115: Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.
has exact synonym: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)
has exact synonym: indole-3-glycerophosphate synthase activity
has exact synonym: indoleglycerol phosphate synthase activity
has exact synonym: indoleglycerol phosphate synthetase activity
has related synonym: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]
type: Class
subclass of: GO_0016831

inorganic diphosphatase activity
IAO_0000115: Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate.
has exact synonym: diphosphate phosphohydrolase activity
has exact synonym: inorganic pyrophosphatase activity
has exact synonym: pyrophosphate phosphohydrolase activity
type: Class
subclass of: GO_0016462

obsolete inositol or phosphatidylinositol kinase activity
IAO_0000115: OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.
type: Class
subclass of: ObsoleteClass

1-phosphatidylinositol 4-kinase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
has exact synonym: ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity
has exact synonym: PI 4-kinase activity
has related synonym: PI kinase activity
has related synonym: PI4-kinase activity
has related synonym: PI4K
has related synonym: PI4K-alpha activity
has related synonym: PtdIns-4-kinase activity
has related synonym: phosphatidylinositol 4-kinase activity
has related synonym: phosphatidylinositol kinase (phosphorylating) activity
has related synonym: phosphatidylinositol kinase activity
has related synonym: type II phosphatidylinositol kinase activity
type: Class
subclass of: GO_0052742

obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA
IAO_0000115: OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events.
type: Class
subclass of: ObsoleteClass

obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB
IAO_0000115: OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins.
type: Class
subclass of: ObsoleteClass

phosphatidylinositol phospholipase C activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
has exact synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
has exact synonym: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
has exact synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
has exact synonym: PI-PLC activity
has exact synonym: phosphoinositidase C activity
has exact synonym: phosphoinositide phospholipase C activity
has related synonym: monophosphatidylinositol phosphodiesterase activity
has related synonym: phosphatidylinositol-4,5-bisphosphate hydrolysis
has related synonym: triphosphoinositide phosphodiesterase activity
type: Class
subclass of: phospholipase C activity

phosphatidylinositol diacylglycerol-lyase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.
has exact synonym: 1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)
has exact synonym: 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
has exact synonym: 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)
has exact synonym: 1-phosphatidylinositol phosphodiesterase activity
has related synonym: monophosphatidylinositol phosphodiesterase activity
type: Class
subclass of: GO_0016849

obsolete inositol or phosphatidylinositol phosphatase activity
IAO_0000115: OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.
type: Class
subclass of: ObsoleteClass

phosphatidylinositol-3-phosphatase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
has exact synonym: 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity
has exact synonym: D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity
has exact synonym: inositol 1,3-bisphosphate phosphatase activity
has exact synonym: inositol-1,3-bisphosphate 3-phosphatase activity
has exact synonym: inositol-1,4,-bisphosphate 3-phosphatase activity
has exact synonym: inositol-polyphosphate 3-phosphatase activity
has exact synonym: phosphatidyl-3-phosphate 3-phosphohydrolase activity
replaces: GO_0016315
type: Class
subclass of: GO_0052744

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
IAO_0000115: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
has exact synonym: PI(4,5)P2 5-phosphatase activity
has exact synonym: PtdIns(4,5)P(2) 5-phosphatase activity
has exact synonym: PtdIns(4,5)P2 5-phosphatase activity
has exact synonym: phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity
has related synonym: phosphatidylinositol 4,5-bisphosphate phosphatase activity
has related synonym: phosphatidylinositol-bisphosphatase activity
has related synonym: triphosphoinositide phosphatase activity
has related synonym: triphosphoinositide phosphomonoesterase activity
replaces: GO_0001668
type: Class
subclass of: GO_0034595
subclass of: GO_0106019

inositol-1,4-bisphosphate 1-phosphatase activity
IAO_0000115: Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.
has exact synonym: 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity
has exact synonym: inositol-polyphosphate 1-phosphatase activity
has related synonym: inositol polyphosphate 1-phosphatase activity
type: Class
subclass of: GO_0016312

obsolete inositol-1,4,-bisphosphate 3-phosphatase
IAO_0000115: OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete inositol-1,4,-bisphosphate 4-phosphatase
IAO_0000115: OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate.
type: Class
subclass of: ObsoleteClass

obsolete inositol-1,4,5-trisphosphate 1-phosphatase
IAO_0000115: OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate.
type: Class
subclass of: ObsoleteClass

inositol-polyphosphate 5-phosphatase activity
IAO_0000115: Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
has exact synonym: D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity
has exact synonym: Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity
has exact synonym: inositol polyphosphate-5-phosphatase activity
has exact synonym: inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity
has related synonym: 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity
has related synonym: 5PTase activity
has related synonym: D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity
has related synonym: D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity
has related synonym: Ins(1,4,5)P(3) 5-phosphatase activity
has related synonym: Ins(1,4,5)P3 5-phosphatase activity
has related synonym: InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity
has related synonym: InsP3/Ins(1,3,4,5)P4 5-phosphatase activity
has related synonym: L-myo-inositol 1,4,5-trisphosphate-monoesterase activity
has related synonym: inosine triphosphatase activity
has related synonym: inositol 1,4,5-trisphosphate phosphatase activity
has related synonym: inositol phosphate 5-phosphomonoesterase activity
has related synonym: inositol triphosphate 5-phosphomonoesterase activity
has related synonym: inositol trisphosphate phosphomonoesterase activity
has related synonym: inositol-1,4,5-trisphosphate 5-phosphatase activity
has related synonym: myo-inositol-1,4,5-trisphosphate 5-phosphatase activity
has related synonym: type I inositol-polyphosphate phosphatase activity
has related synonym: type II inositol polyphosphate 5-phosphatase activity
has related synonym: type II inositol-1,4,5-trisphosphate 5-phosphatase activity
type: Class
subclass of: GO_0046030

inositol-hexakisphosphate phosphatase activity
IAO_0000115: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.
has related synonym: 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity
has related synonym: MIPP activity
has related synonym: inositol tetrakisphosphate phosphomonoesterase activity
has related synonym: multiple inositol-polyphosphate phosphatase activity
type: Class
subclass of: GO_0052745

iodide peroxidase activity
IAO_0000115: Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O.
has exact synonym: iodide peroxidase-tyrosine iodinase activity
has exact synonym: iodide:hydrogen-peroxide oxidoreductase activity
has exact synonym: iodoperoxidase (heme type)
has exact synonym: iodotyrosine deiodase activity
has exact synonym: iodotyrosine deiodinase activity
has exact synonym: monoiodotyrosine deiodinase activity
has exact synonym: tyrosine iodinase activity
has related synonym: TPO activity
has related synonym: iodinase activity
has related synonym: thyroid peroxidase activity
has related synonym: thyroperoxidase activity
type: Class
subclass of: peroxidase activity

isocitrate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
has exact synonym: IDH activity
has exact synonym: IDP activity
has exact synonym: beta-ketoglutaric-isocitric carboxylase activity
has exact synonym: isocitric acid dehydrogenase activity
has exact synonym: isocitric dehydrogenase activity
has exact synonym: oxalosuccinate carboxylase activity
has exact synonym: oxalosuccinate decarboxylase activity
has exact synonym: oxalsuccinic decarboxylase activity
has related synonym: IDP1
has related synonym: IDP2
has related synonym: IDP3
type: Class
subclass of: GO_0016616

isocitrate dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
has exact synonym: NAD dependent isocitrate dehydrogenase activity
has exact synonym: NAD isocitrate dehydrogenase activity
has exact synonym: NAD isocitric dehydrogenase activity
has exact synonym: NAD-linked isocitrate dehydrogenase activity
has exact synonym: NAD-specific isocitrate dehydrogenase activity
has exact synonym: isocitrate dehydrogenase (NAD) activity
has exact synonym: isocitrate:NAD+ oxidoreductase (decarboxylating)
has exact synonym: nicotinamide adenine dinucleotide isocitrate dehydrogenase activity
type: Class
subclass of: isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+.
has exact synonym: NADP isocitric dehydrogenase activity
has exact synonym: NADP(+)-ICDH activity
has exact synonym: NADP(+)-IDH activity
has exact synonym: NADP(+)-linked isocitrate dehydrogenase activity
has exact synonym: NADP-dependent isocitrate dehydrogenase activity
has exact synonym: NADP-dependent isocitric dehydrogenase activity
has exact synonym: NADP-linked isocitrate dehydrogenase activity
has exact synonym: NADP-specific isocitrate dehydrogenase activity
has exact synonym: isocitrate (NADP) dehydrogenase activity
has exact synonym: isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
has exact synonym: isocitrate dehydrogenase (NADP) activity
has exact synonym: isocitrate dehydrogenase (NADP-dependent) activity
has exact synonym: isocitrate:NADP+ oxidoreductase (decarboxylating)
has related synonym: dual-cofactor-specific isocitrate dehydrogenase activity
has related synonym: triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity
type: Class
subclass of: isocitrate dehydrogenase activity

isocitrate lyase activity
IAO_0000115: Catalysis of the reaction: isocitrate = glyoxylate + succinate.
has exact synonym: ICL activity
has exact synonym: isocitrase activity
has exact synonym: isocitratase activity
has exact synonym: isocitrate glyoxylate-lyase (succinate-forming)
has exact synonym: isocitrate glyoxylate-lyase activity
has exact synonym: isocitritase activity
has exact synonym: threo-DS-isocitrate glyoxylate-lyase activity
type: Class
subclass of: GO_0016833

isopentenyl-diphosphate delta-isomerase activity
IAO_0000115: Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.
has exact synonym: IPP isomerase activity
has exact synonym: isopentenyl-diphosphate D-isomerase activity
has exact synonym: isopentenyl-diphosphate delta3-delta2-isomerase activity
has exact synonym: isopentenylpyrophosphate delta-isomerase activity
has exact synonym: isopentenylpyrophosphate isomerase activity
has exact synonym: methylbutenylpyrophosphate isomerase activity
type: Class
subclass of: GO_0016863

juvenile-hormone esterase activity
IAO_0000115: Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.
has exact synonym: JH esterase activity
has exact synonym: JH-esterase activity
has exact synonym: juvenile hormone analog esterase activity
has exact synonym: juvenile hormone carboxyesterase activity
has exact synonym: methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity
type: Class
subclass of: GO_0052689

ketohexokinase activity
IAO_0000115: Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.
has exact synonym: ATP:D-fructose 1-phosphotransferase activity
has exact synonym: ketohexokinase (phosphorylating)
has related synonym: hepatic fructokinase activity
type: Class
subclass of: GO_0016773
subclass of: GO_0019200

ketol-acid reductoisomerase activity
IAO_0000115: Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
has exact synonym: (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
has exact synonym: 2-hydroxy-3-keto acid reductoisomerase activity
has exact synonym: acetohydroxy acid isomeroreductase activity
has exact synonym: acetohydroxy acid reductoisomerase activity
has exact synonym: acetolactate reductoisomerase activity
has exact synonym: alpha-keto-beta-hydroxylacyl reductoisomerase activity
has exact synonym: dihydroxyisovalerate (isomerizing) dehydrogenase activity
has exact synonym: dihydroxyisovalerate dehydrogenase (isomerizing) activity
has exact synonym: isomeroreductase activity
has exact synonym: ketol acid reductoisomerase activity
has exact synonym: reductoisomerase activity
type: Class
subclass of: GO_0016616

phosphogluconate dehydratase activity
IAO_0000115: Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O.
has exact synonym: 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
has exact synonym: 6-phospho-D-gluconate hydro-lyase activity
has exact synonym: 6-phosphogluconate dehydrase activity
has exact synonym: 6-phosphogluconate dehydratase activity
has exact synonym: 6-phosphogluconic dehydrase activity
has exact synonym: gluconate 6-phosphate dehydratase activity
has exact synonym: gluconate-6-phosphate dehydratase activity
type: Class
subclass of: GO_0016836

lactate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate.
type: Class
subclass of: GO_0016614

D-lactate dehydrogenase (cytochrome) activity
IAO_0000115: Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
has exact synonym: (R)-lactate:ferricytochrome-c 2-oxidoreductase activity
has exact synonym: D-(-)-lactic cytochrome c reductase activity
has exact synonym: D-lactate (cytochrome) dehydrogenase activity
has exact synonym: D-lactate ferricytochrome c oxidoreductase activity
has exact synonym: D-lactate-cytochrome c reductase activity
has exact synonym: cytochrome-dependent D-(-)-lactate dehydrogenase activity
has related synonym: lactic acid dehydrogenase activity
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016898

L-lactate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
has exact synonym: L-lactic acid dehydrogenase activity
has exact synonym: L-lactic dehydrogenase activity
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016616

L-lactate dehydrogenase (cytochrome) activity
IAO_0000115: Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
has exact synonym: (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
has exact synonym: L(+)-lactate:cytochrome c oxidoreductase activity
has exact synonym: L-lactate cytochrome c oxidoreductase activity
has exact synonym: L-lactate cytochrome c reductase activity
has exact synonym: L-lactate ferricytochrome c oxidoreductase activity
has exact synonym: dehydrogenase, lactate (cytochrome)
has exact synonym: lactate dehydrogenase (cytochrome)
has exact synonym: lactic cytochrome c reductase activity
has related synonym: cytochrome b2
has related synonym: cytochrome b2 (flavin-free derivative of flavocytochrome b2)
has related synonym: flavocytochrome b2
has related synonym: lactic acid dehydrogenase activity
type: Class
subclass of: lactate dehydrogenase activity
subclass of: GO_0016898

lactose synthase activity
IAO_0000115: Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.
has exact synonym: UDP-galactose-glucose galactosyltransferase activity
has exact synonym: UDP-galactose:D-glucose 4-beta-D-galactotransferase activity
has exact synonym: UDPgalactose-glucose galactosyltransferase activity
has exact synonym: UDPgalactose:D-glucose 4-beta-D-galactotransferase activity
has exact synonym: lactose synthetase activity
has exact synonym: uridine diphosphogalactose-glucose galactosyltransferase activity
type: Class
subclass of: GO_0035250

lactoylglutathione lyase activity
IAO_0000115: Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
has exact synonym: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity
has exact synonym: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
has exact synonym: aldoketomutase activity
has exact synonym: glyoxalase I activity
has exact synonym: ketone-aldehyde mutase activity
has exact synonym: methylglyoxalase activity
has related synonym: glyoxylase I
type: Class
subclass of: GO_0016846

leukotriene-A4 hydrolase activity
IAO_0000115: Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
has exact synonym: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
has exact synonym: LTA-4 hydrolase activity
has exact synonym: LTA4 hydrolase activity
has exact synonym: leukotriene A(4) hydrolase activity
has exact synonym: leukotriene A4 hydrolase activity
has related synonym: LTA4H
type: Class
subclass of: GO_0016803

leukotriene-C4 synthase activity
IAO_0000115: Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).
has exact synonym: (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)
has exact synonym: (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
has exact synonym: LTC(4) synthase activity
has exact synonym: LTC(4) synthetase activity
has exact synonym: LTC4 synthase activity
has exact synonym: LTC4 synthetase activity
has exact synonym: leukotriene A(4):glutathione S-leukotrienyltransferase activity
has exact synonym: leukotriene A4:glutathione S-leukotrienyltransferase activity
has exact synonym: leukotriene C(4) synthetase activity
has exact synonym: leukotriene C4 synthetase activity
has exact synonym: leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
type: Class
subclass of: GO_0016846

lipoprotein lipase activity
IAO_0000115: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein.
has exact synonym: diacylglycerol hydrolase activity
has exact synonym: diacylglycerol lipase activity
has exact synonym: diglyceride lipase activity
has exact synonym: postheparin esterase activity
has exact synonym: postheparin lipase activity
has exact synonym: triacylglycero-protein acylhydrolase activity
has related synonym: clearing factor lipase activity
has related synonym: lipemia-clearing factor
type: Class
subclass of: GO_0004806

long-chain-acyl-CoA dehydrogenase activity
IAO_0000115: Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
has exact synonym: long-chain acyl-coenzyme A dehydrogenase activity
has exact synonym: long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity
has exact synonym: long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity
has exact synonym: palmitoyl-CoA dehydrogenase activity
has exact synonym: palmitoyl-coenzyme A dehydrogenase activity
type: Class
subclass of: acyl-CoA dehydrogenase activity

long-chain fatty acid-CoA ligase activity
IAO_0000115: Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
has exact synonym: LCFA synthetase activity
has exact synonym: acyl-CoA synthetase activity
has exact synonym: fatty acid thiokinase (long chain) activity
has exact synonym: fatty acid thiokinase (long-chain) activity
has exact synonym: lignoceroyl-CoA synthase activity
has exact synonym: long chain fatty acyl-CoA synthetase activity
has exact synonym: long-chain acyl CoA synthetase activity
has exact synonym: long-chain acyl-CoA synthetase activity
has exact synonym: long-chain acyl-coenzyme A synthetase activity
has exact synonym: long-chain fatty acyl coenzyme A synthetase activity
has exact synonym: long-chain-fatty-acid-CoA ligase activity
has exact synonym: long-chain-fatty-acyl-CoA synthetase activity
has related synonym: ACS3
has related synonym: FAA1
has related synonym: acyl-activating enzyme activity
has related synonym: arachidonyl-CoA synthetase
has related synonym: long-chain acyl-CoA synthetase I
has related synonym: long-chain acyl-CoA synthetase II
has related synonym: long-chain fatty acid activation
has related synonym: oleoyl-CoA synthetase
has related synonym: palmitoyl coenzyme A synthetase
has related synonym: palmitoyl-CoA ligase
has related synonym: palmitoyl-CoA synthase
has related synonym: pristanoyl-CoA synthetase
has related synonym: stearoyl-CoA synthetase
has related synonym: thiokinase
type: Class
subclass of: part-of-parent-1676
subclass of: GO_0015645
subclass of: GO_0016405

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
IAO_0000115: Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
has exact synonym: LAT activity
has exact synonym: acetyl-phosphate:L-lysine 6-N-acetyltransferase activity
has exact synonym: acetyl-phosphate:L-lysine N6-acetyltransferase activity
has exact synonym: lysine N(6)-acetyltransferase activity
has exact synonym: lysine N6-acetyltransferase activity
has exact synonym: lysine acetyltransferase activity
type: Class
subclass of: GO_0008080

malic enzyme activity
IAO_0000115: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
has exact synonym: pyruvic-malic carboxylase activity
type: Class
subclass of: GO_0016615

malate dehydrogenase (decarboxylating) (NAD+) activity
IAO_0000115: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.
has exact synonym: (S)-malate:NAD+ oxidoreductase (decarboxylating)
has exact synonym: (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
has exact synonym: malate dehydrogenase (decarboxylating) activity
has exact synonym: malate dehydrogenase (oxaloacetate-decarboxylating) activity
has related synonym: 'malic' enzyme
has related synonym: NAD-linked malic enzyme
has related synonym: NAD-malic enzyme activity
has related synonym: NAD-specific malic enzyme
replaces: GO_0004472
replaces: GO_0016619
type: Class
subclass of: malic enzyme activity
subclass of: GO_0016616

malate dehydrogenase (decarboxylating) (NADP+) activity
IAO_0000115: Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
has exact synonym: (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
has exact synonym: L-malate:NADP oxidoreductase activity
has exact synonym: NADP-malic enzyme activity
has exact synonym: NADP-specific malate dehydrogenase activity
has exact synonym: malate dehydrogenase (NADP, decarboxylating)
has exact synonym: malate dehydrogenase (decarboxylating, NADP)
has related synonym: 'malic' enzyme
has related synonym: NADP-linked decarboxylating malic enzyme
has related synonym: NADP-specific malic enzyme
type: Class
subclass of: malic enzyme activity
subclass of: GO_0016616

malate synthase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).
has exact synonym: L-malate glyoxylate-lyase (CoA-acetylating) activity
has exact synonym: acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
has exact synonym: glyoxylate transacetase activity
has exact synonym: glyoxylate transacetylase activity
has exact synonym: glyoxylic transacetase activity
has exact synonym: malate synthetase activity
has exact synonym: malic synthetase activity
has related synonym: malate condensing enzyme activity
has related synonym: malic-condensing enzyme activity
type: Class
subclass of: GO_0046912

mannose-1-phosphate guanylyltransferase activity
IAO_0000115: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.
has exact synonym: GTP-mannose-1-phosphate guanylyltransferase activity
has exact synonym: GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity
has exact synonym: GTP:mannose-1-phosphate guanylyltransferase activity
has exact synonym: guanosine 5'-diphospho-D-mannose pyrophosphorylase activity
has exact synonym: guanosine diphosphomannose pyrophosphorylase activity
has exact synonym: guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity
has exact synonym: mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
has related synonym: GDP-mannose pyrophosphorylase activity
has related synonym: PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)
type: Class
subclass of: GO_0008905

mannose-6-phosphate isomerase activity
IAO_0000115: Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
has exact synonym: D-mannose-6-phosphate aldose-ketose-isomerase activity
has exact synonym: D-mannose-6-phosphate ketol-isomerase activity
has exact synonym: mannose phosphate isomerase activity
has exact synonym: phosphomannoisomerase activity
has exact synonym: phosphomannose isomerase activity
has related synonym: phosphohexoisomerase activity
has related synonym: phosphohexomutase activity
type: Class
subclass of: GO_0016861

methenyltetrahydrofolate cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
has exact synonym: 5,10-methenyl-THF cyclohydrolase activity
has exact synonym: 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
has exact synonym: citrovorum factor cyclodehydrase activity
has exact synonym: formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
type: Class
subclass of: GO_0019238

methionine adenosyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.
has exact synonym: ATP-methionine adenosyltransferase activity
has exact synonym: ATP:L-methionine S-adenosyltransferase activity
has exact synonym: AdoMet synthetase activity
has exact synonym: S-adenosyl-L-methionine synthetase activity
has exact synonym: S-adenosylmethionine synthase activity
has exact synonym: S-adenosylmethionine synthetase activity
has exact synonym: adenosylmethionine synthetase activity
has exact synonym: methionine S-adenosyltransferase activity
has related synonym: methionine-activating enzyme
type: Class
subclass of: GO_0016765

methionyl-tRNA formyltransferase activity
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.
has exact synonym: 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity
has exact synonym: N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
has exact synonym: N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
has exact synonym: formylmethionyl-transfer ribonucleic synthetase activity
has exact synonym: methionyl ribonucleic formyltransferase activity
has exact synonym: methionyl-tRNA Met formyltransferase activity
has exact synonym: methionyl-tRNA transformylase activity
has exact synonym: methionyl-transfer RNA transformylase activity
has exact synonym: methionyl-transfer ribonucleic transformylase activity
has related synonym: N-terminal peptidyl-methionine N-formylation
has related synonym: conversion of met-tRNAf to fmet-tRNA
has related synonym: conversion of mitochondrial met-tRNAf to fmet-tRNA
has related synonym: methionyl-transfer ribonucleate methyltransferase activity
has related synonym: mitochondrial N-terminal peptidyl-methionine N-formylation
replaces: GO_0001718
replaces: GO_0070128
type: Class
subclass of: part-of-parent-6413
subclass of: part-of-parent-71951
subclass of: GO_0016742
subclass of: GO_0140101

methylene-fatty-acyl-phospholipid synthase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.
has exact synonym: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)
has related synonym: cyclopropane synthetase activity
has related synonym: unsaturated-phospholipid methyltransferase activity
type: Class
subclass of: GO_0008757

mRNA (guanine-N7-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
has exact synonym: S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
has exact synonym: guanine-7-methyltransferase activity
has exact synonym: messenger RNA guanine 7-methyltransferase activity
has exact synonym: messenger ribonucleate guanine 7-methyltransferase activity
type: Class
subclass of: part-of-parent-106005
subclass of: part-of-parent-6370
subclass of: GO_0008170
subclass of: GO_0008174

mRNA (nucleoside-2'-O-)-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
has exact synonym: S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity
has exact synonym: mRNA (adenosine-2'-O-)-methyltransferase activity
has exact synonym: messenger RNA (nucleoside-2'-)-methyltransferase activity
has exact synonym: messenger ribonucleate nucleoside 2'-methyltransferase activity
type: Class
subclass of: GO_0008171
subclass of: GO_0008174

mRNA guanylyltransferase activity
IAO_0000115: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.
has exact synonym: GTP--RNA guanylyltransferase activity
has exact synonym: GTP:mRNA guanylyltransferase activity
has exact synonym: messenger RNA guanylyltransferase activity
has related synonym: mRNA capping enzyme activity
has related synonym: protein lambda2
type: Class
subclass of: GO_0008192

methylcrotonoyl-CoA carboxylase activity
IAO_0000115: Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
has exact synonym: 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)
has exact synonym: MCCC activity
has exact synonym: beta-methylcrotonyl CoA carboxylase activity
has exact synonym: beta-methylcrotonyl coenzyme A carboxylase activity
has exact synonym: beta-methylcrotonyl-CoA carboxylase activity
has exact synonym: methylcrotonyl coenzyme A carboxylase activity
has exact synonym: methylcrotonyl-CoA carboxylase activity
type: Class
subclass of: GO_0016421

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
has exact synonym: 5,10-methylene-THF dehydrogenase activity
has exact synonym: N5,N10-methylenetetrahydrofolate dehydrogenase activity
type: Class
subclass of: GO_0016646

methylenetetrahydrofolate dehydrogenase (NAD+) activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
has exact synonym: 5,10-methylenetetrahydrofolate dehydrogenase activity
has exact synonym: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
type: Class
subclass of: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.
has exact synonym: 5,10-methylenetetrahydrofolate:NADP oxidoreductase activity
has exact synonym: 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity
type: Class
subclass of: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

methylenetetrahydrofolate reductase (NAD(P)H) activity
IAO_0000115: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
has exact synonym: 5,10-CH(2)-H(4)folate reductase activity
has exact synonym: 5,10-CH2-H4folate reductase activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (FADH) activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (FADH2) activity
has exact synonym: 5,10-methylenetetrahydrofolate reductase (NADPH) activity
has exact synonym: 5,10-methylenetetrahydropteroylglutamate reductase activity
has exact synonym: 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NAD+ oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
has exact synonym: 5-methyltetrahydrofolate:NADP+ oxidoreductase activity
has exact synonym: N5,10-methylenetetrahydrofolate reductase activity
has exact synonym: N5,N10-methylenetetrahydrofolate reductase activity
has exact synonym: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
has exact synonym: methylenetetrahydrofolate reductase (NADPH(2)) activity
has exact synonym: methylenetetrahydrofolate reductase (NADPH2)
has related synonym: 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
has related synonym: 5,10-methylenetetrahydrofolate reductase activity
has related synonym: 5,10-methylenetetrahydrofolic acid reductase activity
has related synonym: MTHFR activity
has related synonym: MetF
has related synonym: N(5),N(10)-methylenetetrahydrofolate reductase activity
has related synonym: N(5,10)-methylenetetrahydrofolate reductase activity
has related synonym: methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
has related synonym: methylenetetrahydrofolate reductase [NAD(P)H]
has related synonym: methylenetetrahydrofolate reductase activity
has related synonym: methylenetetrahydrofolic acid reductase activity
replaces: GO_0008702
type: Class
subclass of: GO_0016646

methylglutaconyl-CoA hydratase activity
IAO_0000115: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
has exact synonym: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity
has exact synonym: 3-methylglutaconyl CoA hydratase activity
has exact synonym: methylglutaconase activity
has exact synonym: methylglutaconyl coenzyme A hydratase activity
type: Class
subclass of: GO_0016836

methylmalonate-semialdehyde dehydrogenase (acylating) activity
IAO_0000115: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
has exact synonym: 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
has exact synonym: MMSA dehydrogenase activity
has exact synonym: MSDH activity
type: Class
subclass of: GO_0016620

methylmalonyl-CoA decarboxylase activity
IAO_0000115: Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2.
has exact synonym: (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity
has exact synonym: (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
has exact synonym: (S)-methylmalonyl-CoA carboxy-lyase activity
has exact synonym: methylmalonyl-coenzyme A decarboxylase activity
type: Class
subclass of: GO_0016831

methylmalonyl-CoA epimerase activity
IAO_0000115: Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
has exact synonym: 2-methyl-3-oxopropanoyl-CoA 2-epimerase activity
has exact synonym: DL-methylmalonyl-CoA racemase activity
has exact synonym: methylmalonyl coenzyme A racemase activity
has exact synonym: methylmalonyl-CoA 2-epimerase activity
has exact synonym: methylmalonyl-CoA racemase activity
type: Class
subclass of: GO_0016854

methylmalonyl-CoA mutase activity
IAO_0000115: Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.
has exact synonym: (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity
has exact synonym: (R)-methylmalonyl-CoA CoA-carbonylmutase activity
has exact synonym: (S)-methylmalonyl-CoA mutase activity
has exact synonym: methylmalonyl coenzyme A carbonylmutase activity
has exact synonym: methylmalonyl coenzyme A mutase activity
has exact synonym: methylmalonyl-CoA CoA-carbonyl mutase activity
type: Class
subclass of: GO_0016866

mevaldate reductase activity
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor.
type: Class
subclass of: GO_0016616

mevalonate kinase activity
IAO_0000115: Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+).
has exact synonym: ATP:(R)-mevalonate 5-phosphotransferase activity
has exact synonym: ATP:mevalonate 5-phosphotransferase activity
has exact synonym: MVA kinase activity
has exact synonym: mevalonate 5-phosphotransferase activity
has exact synonym: mevalonate kinase (phosphorylating)
has exact synonym: mevalonate phosphokinase activity
has exact synonym: mevalonic acid kinase activity
has exact synonym: mevalonic kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

monooxygenase activity
IAO_0000115: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
has related synonym: hydroxylase activity
type: Class
subclass of: GO_0016491

calcidiol 1-monooxygenase activity
IAO_0000115: Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
has exact synonym: 25-OHD-1 alpha-hydroxylase activity
has exact synonym: 25-hydroxy D3-1alpha-hydroxylase activity
has exact synonym: 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol 1-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol 1-monooxygenase activity
has exact synonym: 25-hydroxycholecalciferol 1alpha-hydroxylase activity
has exact synonym: 25-hydroxycholecalciferol-1-hydroxylase activity
has exact synonym: 25-hydroxyvitamin D-1 alpha hydroxylase activity
has exact synonym: 25-hydroxyvitamin D3 1alpha-hydroxylase activity
has exact synonym: calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
has related synonym: 1-hydroxylase-25-hydroxyvitamin D3 activity
has related synonym: cytochrome P450 CYP27B
type: Class
subclass of: part-of-parent-36378
subclass of: GO_0016709

N,N-dimethylaniline monooxygenase activity
IAO_0000115: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
has exact synonym: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity
has exact synonym: DMA oxidase activity
has exact synonym: N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
has exact synonym: dimethylaniline N-oxidase activity
has exact synonym: dimethylaniline monooxygenase (N-oxide-forming) activity
has exact synonym: dimethylaniline oxidase activity
has exact synonym: methylphenyltetrahydropyridine N-monooxygenase activity
has related synonym: FAD-containing monooxygenase activity
has related synonym: FMO activity
has related synonym: FMO-I
has related synonym: FMO-II
has related synonym: FMO1
has related synonym: FMO2
has related synonym: FMO3
has related synonym: FMO4
has related synonym: FMO5
has related synonym: Ziegler's enzyme
has related synonym: flavin mixed function oxidase activity
has related synonym: flavin monooxygenase activity
has related synonym: flavin-containing monooxygenase activity
has related synonym: mixed-function amine oxidase activity
replaces: GO_0047076
type: Class
subclass of: GO_0016709

dopamine beta-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O.
has exact synonym: (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity
has exact synonym: 3,4-dihydroxyphenethylamine beta-oxidase activity
has exact synonym: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
has exact synonym: 4-(2-aminoethyl)pyrocatechol beta-oxidase activity
has exact synonym: dopa beta-hydroxylase activity
has exact synonym: dopamine b-hydroxylase activity
has exact synonym: dopamine beta-hydroxylase activity
has exact synonym: dopamine beta-oxidase activity
has exact synonym: dopamine hydroxylase activity
has exact synonym: dopamine-B-hydroxylase activity
has exact synonym: oxygenase, dopamine beta-mono-
has exact synonym: phenylamine beta-hydroxylase activity
has related synonym: MDBH (membrane-associated dopamine beta-monooxygenase)
has related synonym: SDBH (soluble dopamine beta-monooxygenase)
type: Class
subclass of: GO_0016715

ecdysone 20-monooxygenase activity
IAO_0000115: Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O.
has exact synonym: alpha-ecdysone C-20 hydroxylase activity
has exact synonym: ecdysone 20-hydroxylase activity
has exact synonym: ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)
has related synonym: ecdysone modification
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

kynurenine 3-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).
has exact synonym: L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
has exact synonym: L-kynurenine-3-hydroxylase activity
has exact synonym: kynurenine 3-hydroxylase activity
has exact synonym: kynurenine hydroxylase activity
type: Class
subclass of: GO_0016709

monophenol monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.
has exact synonym: L-tyrosine monooxygenase activity
has exact synonym: N-acetyl-6-hydroxytryptophan oxidase activity
has exact synonym: monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity
has exact synonym: monophenol monooxidase activity
has exact synonym: monophenol oxidase activity
has exact synonym: monophenol oxygenase
has exact synonym: monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity
has exact synonym: monophenol,L-dopa:oxygen oxidoreductase activity
has exact synonym: monophenolase activity
has exact synonym: polyaromatic oxidase activity
has exact synonym: polyphenolase activity
has exact synonym: tyrosinase activity
has exact synonym: tyrosine-dopa oxidase activity
has related synonym: catecholase
has related synonym: chlorogenic acid oxidase activity
has related synonym: chlorogenic oxidase activity
has related synonym: cresolase activity
has related synonym: dopa oxidase
has related synonym: o-diphenol oxidase activity
has related synonym: o-diphenol oxidoreductase
has related synonym: o-diphenol:O2 oxidoreductase activity
has related synonym: o-diphenol:oxygen oxidoreductase
has related synonym: phenol oxidase activity
has related synonym: phenolase activity
has related synonym: prophenol oxidase activity
has related synonym: prophenoloxidase activity
has related synonym: pyrocatechol oxidase
type: Class
subclass of: GO_0016716

peptidylglycine monooxygenase activity
IAO_0000115: Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.
has exact synonym: PAM activity
has exact synonym: peptide alpha-amide synthase activity
has exact synonym: peptide-alpha-amide synthetase activity
has exact synonym: peptidyl alpha-amidating enzyme activity
has exact synonym: peptidylglycine 2-hydroxylase activity
has exact synonym: peptidylglycine alpha-amidating monooxygenase activity
has exact synonym: peptidylglycine alpha-hydroxylase activity
has exact synonym: peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
has exact synonym: synthase, peptide alpha-amide
has related synonym: PAM-A
has related synonym: PAM-B
has related synonym: peptide alpha-amidating enzyme
type: Class
subclass of: GO_0016715

phenylalanine 4-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
has exact synonym: L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
has exact synonym: PAH activity
has exact synonym: phenylalaninase activity
has exact synonym: phenylalanine 4-hydroxylase activity
has exact synonym: phenylalanine hydroxylase activity
type: Class
subclass of: GO_0016714

squalene monooxygenase activity
IAO_0000115: Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
has exact synonym: squalene 2,3-oxidocyclase activity
has exact synonym: squalene epoxidase activity
has exact synonym: squalene hydroxylase activity
has exact synonym: squalene oxydocyclase activity
has exact synonym: squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
has exact synonym: squalene-2,3-epoxidase activity
has exact synonym: squalene-2,3-epoxide cyclase activity
type: Class
subclass of: GO_0016709

steroid 11-beta-monooxygenase activity
IAO_0000115: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
has exact synonym: oxygenase, steroid 11beta -mono-
has exact synonym: steroid 11-beta-hydroxylase activity
has exact synonym: steroid 11-beta/18-hydroxylase activity
has exact synonym: steroid 11beta-hydroxylase activity
has exact synonym: steroid 11beta-monooxygenase activity
has exact synonym: steroid 11beta/18-hydroxylase activity
has exact synonym: steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
has related synonym: cytochrome P450 CYP11B1
has related synonym: cytochrome P450 CYP11B2
has related synonym: cytochrome p450 XIB1 activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016713

steroid 17-alpha-monooxygenase activity
IAO_0000115: Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
has exact synonym: 17alpha-hydroxylase-C17,20 lyase activity
has exact synonym: steroid 17-alpha-hydroxylase activity
has exact synonym: steroid 17-alpha-hydroxylase-C17-20 lyase activity
has exact synonym: steroid 17-alpha-hydroxylase/17,20 lyase activity
has exact synonym: steroid 17alpha-hydroxylase activity
has exact synonym: steroid 17alpha-monooxygenase activity
has exact synonym: steroid 17alphahydroxylase/17,20 lyase activity
has exact synonym: steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
has related synonym: cytochrome P-450 (P-45017alpha,lyase)
has related synonym: cytochrome P450 CYP17
has related synonym: cytochrome P45017alpha
has related synonym: cytochrome p450 XVIIA1 activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

steroid 21-monooxygenase activity
IAO_0000115: Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
has exact synonym: 21-hydroxylase activity
has exact synonym: steroid 21-hydroxylase activity
has exact synonym: steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
has related synonym: cytochrome P450 CYP21A1
has related synonym: cytochrome p450 XXIA1 activity
type: Class
subclass of: GO_0008395
subclass of: GO_0016705

tryptophan 5-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.
has exact synonym: L-tryptophan hydroxylase activity
has exact synonym: L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
has exact synonym: indoleacetic acid-5-hydroxylase activity
has exact synonym: tryptophan 5-hydroxylase activity
has exact synonym: tryptophan hydroxylase activity
type: Class
subclass of: GO_0016714

tyrosine 3-monooxygenase activity
IAO_0000115: Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.
has exact synonym: L-tyrosine hydroxylase activity
has exact synonym: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
has exact synonym: tyrosine 3-hydroxylase activity
has exact synonym: tyrosine hydroxylase activity
type: Class
subclass of: GO_0016714

inositol-3-phosphate synthase activity
IAO_0000115: Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
has exact synonym: 1L-myo-inositol-1-phosphate lyase (isomerizing)
has exact synonym: D-glucose 6-phosphate cycloaldolase activity
has exact synonym: glucocycloaldolase activity
has exact synonym: glucose 6-phosphate cyclase activity
has exact synonym: glucose-6-phosphate inositol monophosphate cycloaldolase activity
has exact synonym: inositol 1-phosphate synthatase activity
has exact synonym: inositol 1-phosphate synthetase activity
type: Class
subclass of: GO_0016872

neolactotetraosylceramide alpha-2,3-sialyltransferase activity
IAO_0000115: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide.
has exact synonym: CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity
has exact synonym: cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity
has related synonym: SAT-3
has related synonym: sialyltransferase 3
type: Class
subclass of: GO_0008373

nicotinate-nucleotide diphosphorylase (carboxylating) activity
IAO_0000115: Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate.
has exact synonym: NAD pyrophosphorylase activity
has exact synonym: QAPRTase activity
has exact synonym: nicotinate mononucleotide pyrophosphorylase (carboxylating)
has exact synonym: nicotinate-nucleotide pyrophosphorylase (carboxylating) activity
has exact synonym: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
has exact synonym: quinolinate phosphoribosyltransferase (decarboxylating) activity
has exact synonym: quinolinic acid phosphoribosyltransferase activity
has exact synonym: quinolinic phosphoribosyltransferase activity
type: Class
subclass of: GO_0016763

nicotinate-nucleotide adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.
has exact synonym: ATP:nicotinate-nucleotide adenylyltransferase activity
has exact synonym: ATP:nicotinate-ribonucleotide adenylyltransferase activity
has exact synonym: NaMN-ATase activity
has exact synonym: deamido-NAD(+) diphosphorylase activity
has exact synonym: deamido-NAD(+) pyrophosphorylase activity
has exact synonym: deamido-NAD+ pyrophosphorylase activity
has exact synonym: deamidonicotinamide adenine dinucleotide pyrophosphorylase activity
has exact synonym: nicotinate mononucleotide adenylyltransferase activity
has related synonym: nicotinic acid mononucleotide adenylyltransferase
type: Class
subclass of: GO_0070566

nicotinate phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
has exact synonym: niacin ribonucleotidase activity
has exact synonym: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
has exact synonym: nicotinic acid mononucleotide glycohydrolase activity
has exact synonym: nicotinic acid mononucleotide pyrophosphorylase activity
has exact synonym: nicotinic acid phosphoribosyltransferase activity
type: Class
subclass of: GO_0016879

nitric-oxide synthase activity
IAO_0000115: Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
has exact synonym: L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
has exact synonym: NADPH-diaphorase activity
has exact synonym: NO synthase activity
has exact synonym: nitric oxide synthase activity
has exact synonym: nitric oxide synthetase activity
has exact synonym: nitric-oxide synthetase activity
has related synonym: endothelium-derived relaxation factor-forming enzyme activity
has related synonym: endothelium-derived relaxing factor synthase activity
type: Class
subclass of: GO_0016709

nuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids.
type: Class
subclass of: part-of-parent-90305
subclass of: GO_0016788

endonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
type: Class
subclass of: nuclease activity

endodeoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
has related synonym: DNA nicking activity
has related synonym: endonuclease G activity
type: Class
subclass of: endonuclease activity
subclass of: deoxyribonuclease activity

endoribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
has related synonym: endonuclease G activity
type: Class
subclass of: endonuclease activity
subclass of: part-of-parent-90502
subclass of: ribonuclease activity

ribonuclease A activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.
has exact synonym: RNase A activity
has exact synonym: RNase I activity
has exact synonym: alkaline ribonuclease activity
has exact synonym: ceratitis capitata alkaline ribonuclease activity
has exact synonym: pancreatic RNase activity
has exact synonym: ribonuclease I activity
has exact synonym: ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity
has exact synonym: ribonucleic phosphatase activity
has related synonym: RNase activity
has related synonym: S-genotype-assocd. glycoproteins
has related synonym: SLSG glycoproteins
has related synonym: endoribonuclease I
has related synonym: gene S glycoproteins
has related synonym: gene S locus-specific glycoproteins
has related synonym: pancreatic ribonuclease activity
type: Class
subclass of: GO_0016892

RNA-DNA hybrid ribonuclease activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
has exact synonym: RNA*DNA hybrid ribonucleotidohydrolase activity
has exact synonym: RNase H activity
has exact synonym: calf thymus ribonuclease H activity
has exact synonym: hybrid nuclease activity
has exact synonym: hybrid ribonuclease activity
has exact synonym: hybridase (ribonuclease H)
has exact synonym: hybridase activity
has exact synonym: ribonuclease H activity
has related synonym: RNase H1 activity
has related synonym: RNase H2 activity
has related synonym: RNase H3 activity
has related synonym: endoribonuclease H
has related synonym: endoribonuclease H (calf thymus)
has related synonym: endoribonuclease0 H activity
has related synonym: ribonuclease H1 activity
has related synonym: ribonuclease H2 activity
has related synonym: ribonuclease H3 activity
replaces: GO_0004524
type: Class
subclass of: GO_0016891

ribonuclease III activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
has exact synonym: RNase III activity
has exact synonym: ribonuclease 3 activity
has related synonym: pre-mRNA 3'-end processing endonuclease
type: Class
subclass of: GO_0016891
subclass of: GO_0032296

ribonuclease P activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.
has exact synonym: RNase P
has exact synonym: tRNA 5' leader endonuclease activity
type: Class
subclass of: tRNA-specific ribonuclease activity
subclass of: GO_0016891

exonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
has related synonym: exonuclease IX activity
replaces: GO_0008857
type: Class
subclass of: nuclease activity

phosphodiesterase I activity
IAO_0000115: Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
has exact synonym: 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
has exact synonym: PDE I activity
has exact synonym: nucleotide pyrophosphatase/phosphodiesterase I activity
has exact synonym: oligonucleate 5'-nucleotidohydrolase activity
has exact synonym: orthophosphoric diester phosphohydrolase activity
has related synonym: 5'-NPDase activity
has related synonym: 5'-PDE activity
has related synonym: 5'-PDase activity
has related synonym: 5'-exonuclease activity
has related synonym: 5'-nucleotide phosphodiesterase activity
has related synonym: 5'-phosphodiesterase activity
has related synonym: 5'NPDE activity
has related synonym: alkaline phosphodiesterase activity
has related synonym: exonuclease I activity
has related synonym: phosphodiesterase activity
type: Class
subclass of: exonuclease activity
subclass of: GO_0008081

exodeoxyribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
type: Class
subclass of: exonuclease activity
subclass of: deoxyribonuclease activity

deoxyribonuclease I activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.
has exact synonym: DNA depolymerase activity
has exact synonym: DNA endonuclease activity
has exact synonym: DNA nuclease activity
has exact synonym: DNAase activity
has exact synonym: alkaline DNase activity
has exact synonym: alkaline deoxyribonuclease activity
has exact synonym: deoxyribonucleic phosphatase activity
has exact synonym: thymonuclease, dornase activity
has related synonym: DNase I
has related synonym: DNase activity
has related synonym: Escherichia coli endonuclease I
has related synonym: deoxyribonuclease (pancreatic)
has related synonym: deoxyribonuclease A
has related synonym: dornava
has related synonym: dornavac
has related synonym: endodeoxyribonuclease I
has related synonym: pancreatic DNase activity
has related synonym: pancreatic deoxyribonuclease
has related synonym: pancreatic dornase
has related synonym: thymonuclease activity
type: Class
subclass of: GO_0016888

deoxyribonuclease II activity
IAO_0000115: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.
has exact synonym: DNase II activity
has exact synonym: acid DNase activity
has exact synonym: acid deoxyribonuclease activity
has exact synonym: deoxyribonucleate 3'-nucleotidohydrolase activity
has related synonym: lysosomal DNase II activity
has related synonym: pancreatic DNase II
type: Class
subclass of: GO_0016889

exoribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
type: Class
subclass of: exonuclease activity
subclass of: part-of-parent-90503
subclass of: ribonuclease activity

exoribonuclease H activity
IAO_0000115: Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.
has related synonym: retroviral reverse transcriptase RNaseH
type: Class
subclass of: GO_0016896

5'-3' exoribonuclease activity
IAO_0000115: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.
type: Class
subclass of: GO_0008409
subclass of: GO_0016896

poly(A)-specific ribonuclease activity
IAO_0000115: Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
has exact synonym: 3'-exoribonuclease activity
has exact synonym: poly(A)-specific RNase activity
has related synonym: 2',3'-exoribonuclease activity
type: Class
subclass of: 3'-5'-exoribonuclease activity

deoxyribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
has related synonym: caspase-activated deoxyribonuclease activity
replaces: GO_0004537
type: Class
subclass of: nuclease activity
subclass of: part-of-parent-6259
subclass of: GO_0140097

ribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
type: Class
subclass of: nuclease activity
subclass of: part-of-parent-90501
subclass of: GO_0140098

tRNA-specific ribonuclease activity
IAO_0000115: Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
has exact synonym: tRNA-specific RNase activity
type: Class
subclass of: ribonuclease activity
subclass of: GO_0140101

nucleoside diphosphate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
has exact synonym: ATP:nucleoside-diphosphate phosphotransferase activity
has exact synonym: NDK activity
has exact synonym: UDP kinase activity
has exact synonym: nucleoside 5'-diphosphate kinase activity
has exact synonym: nucleoside 5'-diphosphate phosphotransferase activity
has exact synonym: nucleoside diphosphate (UDP) kinase activity
has exact synonym: nucleoside diphosphokinase activity
has exact synonym: nucleoside-diphosphate kinase activity
has exact synonym: nucleotide phosphate kinase activity
has exact synonym: uridine diphosphate kinase activity
type: Class
subclass of: part-of-parent-6165
subclass of: GO_0016776
subclass of: GO_0019205

nucleotide diphosphatase activity
IAO_0000115: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.
has exact synonym: dinucleotide nucleotidohydrolase activity
has exact synonym: nucleotide pyrophosphatase activity
has exact synonym: nucleotide-sugar pyrophosphatase activity
type: Class
subclass of: GO_0016462

octanol dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH.
has exact synonym: 1-octanol dehydrogenase activity
has exact synonym: octanol:NAD+ oxidoreductase activity
type: Class
subclass of: GO_0016616

hydrolase activity, hydrolyzing O-glycosyl compounds
IAO_0000115: Catalysis of the hydrolysis of any O-glycosyl bond.
has exact synonym: O-glucosyl hydrolase activity
replaces: GO_0016800
type: Class
subclass of: GO_0016798

alpha,alpha-trehalase activity
IAO_0000115: Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
has exact synonym: alpha,alpha-trehalose glucohydrolase activity
type: Class
subclass of: GO_0015927

alpha-amylase activity
IAO_0000115: Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
has exact synonym: 1,4-alpha-D-glucan glucanohydrolase activity
has exact synonym: alpha amylase activity
has exact synonym: endoamylase activity
has related synonym: glycogenase activity
has related synonym: taka-amylase A
type: Class
subclass of: GO_0016160

alpha-galactosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase.
has exact synonym: alpha-D-galactosidase activity
has exact synonym: alpha-D-galactoside galactohydrolase activity
has exact synonym: alpha-galactoside galactohydrolase activity
has exact synonym: melibiase activity
has related synonym: alpha-galactosidase A
type: Class
subclass of: GO_0015925

alpha-1,4-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
has exact synonym: acid maltase activity
has exact synonym: alpha-1,4-glucosidase activity
has exact synonym: alpha-D-glucosidase activity
has exact synonym: alpha-D-glucoside glucohydrolase activity
has exact synonym: alpha-glucopyranosidase activity
has exact synonym: alpha-glucoside hydrolase activity
has exact synonym: glucoinvertase activity
has exact synonym: glucosidoinvertase activity
has exact synonym: glucosidosucrase activity
has exact synonym: maltase-glucoamylase activity
has related synonym: alpha-glucosidase II
has related synonym: lysosomal alpha-glucosidase activity
replaces: GO_0004562
replaces: GO_0016982
type: Class
subclass of: GO_0090599

alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
has exact synonym: alpha-D-mannopyranosidase activity
has exact synonym: alpha-D-mannosidase activity
has exact synonym: alpha-D-mannoside mannohydrolase activity
has exact synonym: exo-alpha-mannosidase activity
has related synonym: 1,2-alpha-D-mannosidase activity
has related synonym: 1,2-alpha-mannosidase
has related synonym: p-nitrophenyl-alpha-mannosidase activity
type: Class
subclass of: GO_0015923

alpha-L-fucosidase activity
IAO_0000115: Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.
has exact synonym: alpha-L-fucoside fucohydrolase activity
has exact synonym: alpha-fucosidase activity
type: Class
subclass of: GO_0015928

alpha-N-acetylglucosaminidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.
has exact synonym: N-acetyl-alpha-D-glucosaminidase activity
has exact synonym: N-acetyl-alpha-glucosaminidase activity
has exact synonym: NAG activity
has exact synonym: alpha-D-2-acetamido-2-deoxyglucosidase activity
has exact synonym: alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity
has exact synonym: alpha-acetylglucosaminidase activity
type: Class
subclass of: GO_0015929

beta-N-acetylhexosaminidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
has exact synonym: N-acetyl-beta-D-hexosaminidase activity
has exact synonym: N-acetyl-beta-glucosaminidase activity
has exact synonym: N-acetyl-beta-hexosaminidase activity
has exact synonym: N-acetylhexosaminidase activity
has exact synonym: beta-D-N-acetylhexosaminidase activity
has exact synonym: beta-D-hexosaminidase activity
has exact synonym: beta-N-acetyl-D-hexosaminidase activity
has exact synonym: beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity
has exact synonym: beta-acetylaminodeoxyhexosidase activity
has exact synonym: beta-acetylhexosaminidinase activity
has exact synonym: beta-hexosaminidase activity
has related synonym: hexosaminidase A
type: Class
subclass of: GO_0015929

beta-fructofuranosidase activity
IAO_0000115: Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside.
has exact synonym: beta-D-fructofuranoside fructohydrolase activity
has related synonym: acid invertase activity
has related synonym: alkaline invertase activity
has related synonym: beta-fructosidase activity
has related synonym: beta-h-fructosidase activity
has related synonym: fructosylinvertase activity
has related synonym: glucosucrase activity
has related synonym: invertase activity
has related synonym: invertin activity
has related synonym: maxinvert L 1000 activity
has related synonym: saccharase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

beta-galactosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
has exact synonym: beta-D-galactanase activity
has exact synonym: beta-D-galactoside galactohydrolase activity
has exact synonym: beta-D-lactosidase activity
has exact synonym: beta-lactosidase activity
has exact synonym: exo-(1->4)-beta-D-galactanase activity
has exact synonym: trilactase activity
has related synonym: S 2107
has related synonym: hydrolact
has related synonym: lactose hydrolysis
has related synonym: lactozym
has related synonym: maxilact
has related synonym: oryzatym
has related synonym: sumiklat
type: Class
subclass of: GO_0015925

beta-glucuronidase activity
IAO_0000115: Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.
has exact synonym: beta-D-glucuronoside glucuronosohydrolase activity
has exact synonym: beta-glucuronide glucuronohydrolase activity
has exact synonym: exo-beta-D-glucuronidase activity
has exact synonym: glucuronidase activity
has exact synonym: ketodase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

beta-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.
has exact synonym: beta-D-mannosidase activity
has exact synonym: beta-D-mannoside mannohydrolase activity
has exact synonym: beta-mannoside mannohydrolase activity
has exact synonym: exo-beta-D-mannanase activity
has exact synonym: mannanase activity
has exact synonym: mannase activity
type: Class
subclass of: GO_0015923

chitinase activity
IAO_0000115: Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.
has exact synonym: 1,4-beta-poly-N-acetylglucosaminidase activity
has exact synonym: beta-1,4-poly-N-acetyl glucosamidinase activity
has exact synonym: chitodextrinase activity
has exact synonym: poly-beta-glucosaminidase activity
has exact synonym: poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

glycoprotein endo-alpha-1,2-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.
has exact synonym: endo-alpha-mannosidase activity
has exact synonym: endomannosidase activity
has exact synonym: glucosyl mannosidase activity
has exact synonym: glucosylmannosidase activity
has exact synonym: glycoprotein glucosylmannohydrolase activity
type: Class
subclass of: alpha-mannosidase activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.
has exact synonym: 1,2-alpha-mannosidase
has exact synonym: 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity
has exact synonym: exo-alpha-1,2-mannanase activity
has related synonym: Man9-mannosidase activity
has related synonym: ManI activity
has related synonym: glycoprotein processing mannosidase I
has related synonym: man9-mannosidase activity
has related synonym: mannose-9 processing alpha-mannosidase activity
has related synonym: mannosidase 1A activity
has related synonym: mannosidase 1B activity
has related synonym: mannosidase I
type: Class
subclass of: GO_0015924

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
IAO_0000115: Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
has exact synonym: 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity
has exact synonym: GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity
has exact synonym: alpha-(1,3/6)-mannosidase activity
has exact synonym: exo-1,3-1,6-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity
has exact synonym: mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity
has related synonym: Golgi alpha-mannosidase II
has related synonym: ManII activity
has related synonym: alpha-D-mannosidase II
has related synonym: alpha-mannosidase II
has related synonym: mannosidase II activity
type: Class
subclass of: GO_0015924

mannosyl-oligosaccharide glucosidase activity
IAO_0000115: Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
has exact synonym: Glc3Man9NAc2 oligosaccharide glucosidase activity
has exact synonym: mannosyl-oligosaccharide glucohydrolase activity
has exact synonym: mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity
has related synonym: processing A-glucosidase I activity
has related synonym: trimming glucosidase I
type: Class
subclass of: GO_0015926

oligo-1,6-glucosidase activity
IAO_0000115: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.
has exact synonym: alpha-limit dextrinase activity
has exact synonym: dextrin 6-glucanohydrolase activity
has exact synonym: dextrin 6alpha-glucanohydrolase activity
has exact synonym: exo-oligo-1,6-glucosidase activity
has exact synonym: oligosaccharide alpha-1,6-glucohydrolase activity
has exact synonym: oligosaccharide alpha-1,6-glucosidase activity
has related synonym: alpha-methylglucosidase activity
has related synonym: isomaltase activity
has related synonym: limit dextrinase
has related synonym: sucrase-isomaltase activity
type: Class
subclass of: GO_0090599

sucrose alpha-glucosidase activity
IAO_0000115: Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.
has exact synonym: sucrose alpha-D-glucohydrolase activity
has exact synonym: sucrose alpha-glucohydrolase activity
has exact synonym: sucrose-alpha-D-glucohydrolase activity
has related synonym: alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis
has related synonym: beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis
has related synonym: intestinal sucrase activity
has related synonym: sucrase activity
has related synonym: sucrase(invertase)
has related synonym: sucrase-isomaltase activity
has related synonym: sucrose hydrolysis
type: Class
subclass of: beta-fructofuranosidase activity
subclass of: GO_0090599

oligosaccharyl transferase activity
IAO_0000115: Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.
has exact synonym: oligosaccharide transferase activity
type: Class
subclass of: GO_0016758

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol.
has exact synonym: N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity
has exact synonym: UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity
has exact synonym: UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity
has exact synonym: uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity
type: Class
subclass of: GO_0008375

chitobiosyldiphosphodolichol beta-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.
has exact synonym: GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity
has exact synonym: GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity
has exact synonym: guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity
type: Class
subclass of: GO_0019187

dolichyl-diphosphooligosaccharide-protein glycotransferase activity
IAO_0000115: Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.
has exact synonym: asparagine N-glycosyltransferase activity
has exact synonym: dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity
has exact synonym: dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity
has exact synonym: dolichyldiphosphooligosaccharide-protein glycosyltransferase activity
has exact synonym: dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity
has exact synonym: dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity
has exact synonym: dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity
has related synonym: oligomannosyltransferase activity
type: Class
subclass of: oligosaccharyl transferase activity

dolichyl-phosphate beta-glucosyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.
has exact synonym: UDP-glucose dolichyl-phosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolichol phosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolicholphosphoryl glucosyltransferase activity
has exact synonym: UDP-glucose:dolichyl monophosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolichyl phosphate glucosyltransferase activity
has exact synonym: UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity
has exact synonym: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity
has exact synonym: polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity
has exact synonym: uridine diphosphoglucose-dolichol glucosyltransferase activity
type: Class
subclass of: GO_0035251

dolichyl-phosphate beta-D-mannosyltransferase activity
IAO_0000115: Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
has exact synonym: DPM synthase activity
has exact synonym: GDP-mannose-dolichol phosphate mannosyltransferase activity
has exact synonym: GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity
has exact synonym: GDPMan:DolP mannosyltransferase activity
has exact synonym: GDPmannose-dolichylmonophosphate mannosyltransferase activity
has exact synonym: GDPmannose:dolichyl-phosphate mannosyltransferase activity
has exact synonym: dolichol phosphate mannose synthase activity
has exact synonym: dolichol-phosphate mannose synthase activity
has exact synonym: dolichol-phosphate mannosyltransferase activity
has exact synonym: dolichol-phosphate-mannose synthase activity
has exact synonym: dolichyl mannosyl phosphate synthase activity
has exact synonym: dolichyl phosphate mannosyltransferase activity
has exact synonym: dolichyl-phosphate mannose synthase activity
has exact synonym: dolichyl-phospho-mannose synthase activity
has exact synonym: guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity
has exact synonym: mannosylphosphodolichol synthase activity
has exact synonym: mannosylphosphoryldolichol synthase activity
type: Class
subclass of: mannosyltransferase activity

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
IAO_0000115: Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.
type: Class
subclass of: GO_0046527

obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
IAO_0000115: OBSOLETE. Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide.
type: Class
subclass of: ObsoleteClass

ornithine carbamoyltransferase activity
IAO_0000115: Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
has exact synonym: L-ornithine carbamoyltransferase activity
has exact synonym: L-ornithine carbamyltransferase activity
has exact synonym: L-ornithine transcarbamylase activity
has exact synonym: OTC activity
has exact synonym: OTCase activity
has exact synonym: carbamoyl-phosphate:L-ornithine carbamoyltransferase activity
has exact synonym: carbamylphosphate-ornithine transcarbamylase activity
has exact synonym: citrulline phosphorylase activity
has exact synonym: ornithine carbamyltransferase activity
has exact synonym: ornithine transcarbamylase activity
type: Class
subclass of: part-of-parent-6591
subclass of: GO_0016743

ornithine decarboxylase activity
IAO_0000115: Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine.
has exact synonym: L-ornithine carboxy-lyase (putrescine-forming)
has related synonym: L-ornithine carboxy-lyase activity
has related synonym: SpeC
type: Class
subclass of: GO_0016831

ornithine-oxo-acid transaminase activity
IAO_0000115: Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
has exact synonym: L-ornithine 5-aminotransferase activity
has exact synonym: L-ornithine aminotransferase activity
has exact synonym: L-ornithine:2-oxo-acid aminotransferase activity
has exact synonym: L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
has exact synonym: ornithine 5-aminotransferase activity
has exact synonym: ornithine aminotransferase activity
has exact synonym: ornithine delta-transaminase activity
has exact synonym: ornithine ketoacid aminotransferase activity
has exact synonym: ornithine transaminase activity
has exact synonym: ornithine--2-oxoacid aminotransferase activity
has exact synonym: ornithine--alpha-ketoglutarate aminotransferase activity
has exact synonym: ornithine--keto acid aminotransferase activity
has exact synonym: ornithine--keto acid transaminase activity
has exact synonym: ornithine--ketoglutarate aminotransferase activity
has exact synonym: ornithine--oxo acid aminotransferase activity
has exact synonym: ornithine--oxo-acid transaminase activity
has exact synonym: ornithine-oxo-acid aminotransferase activity
has exact synonym: ornithine:alpha-oxoglutarate transaminase activity
has related synonym: GabT
has related synonym: OAT
type: Class
subclass of: GO_0008483

orotate phosphoribosyltransferase activity
IAO_0000115: Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
has exact synonym: OPRT activity
has exact synonym: OPRTase activity
has exact synonym: orotate phosphoribosyl pyrophosphate transferase activity
has exact synonym: orotic acid phosphoribosyltransferase activity
has exact synonym: orotidine 5'-monophosphate pyrophosphorylase activity
has exact synonym: orotidine monophosphate pyrophosphorylase activity
has exact synonym: orotidine phosphoribosyltransferase activity
has exact synonym: orotidine-5'-phosphate diphosphorylase activity
has exact synonym: orotidine-5'-phosphate pyrophosphorylase activity
has exact synonym: orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity
has exact synonym: orotidylate phosphoribosyltransferase activity
has exact synonym: orotidylate pyrophosphorylase activity
has exact synonym: orotidylic acid phosphorylase activity
has exact synonym: orotidylic acid pyrophosphorylase activity
has exact synonym: orotidylic phosphorylase activity
has exact synonym: orotidylic pyrophosphorylase activity
type: Class
subclass of: GO_0016763

orotate reductase (NADH) activity
IAO_0000115: Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate.
has exact synonym: (S)-dihydroorotate:NAD+ oxidoreductase activity
type: Class
subclass of: GO_0016628

orotidine-5'-phosphate decarboxylase activity
IAO_0000115: Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.
has exact synonym: ODCase activity
has exact synonym: OMP decarboxylase activity
has exact synonym: OMPdcase activity
has exact synonym: UMP synthase activity
has exact synonym: orotate decarboxylase activity
has exact synonym: orotate monophosphate decarboxylase activity
has exact synonym: orotic decarboxylase activity
has exact synonym: orotidine 5'-phosphate decarboxylase activity
has exact synonym: orotidine monophosphate decarboxylase activity
has exact synonym: orotidine phosphate decarboxylase activity
has exact synonym: orotidine-5'-monophosphate decarboxylase activity
has exact synonym: orotidine-5'-phosphate carboxy-lyase (UMP-forming)
has exact synonym: orotidine-5'-phosphate carboxy-lyase activity
has exact synonym: orotidylic acid decarboxylase activity
has exact synonym: orotidylic decarboxylase activity
has exact synonym: orotodylate decarboxylase activity
has exact synonym: uridine 5'-monophosphate synthase activity
has related synonym: OMP-DC
type: Class
subclass of: GO_0016831

oxoglutarate dehydrogenase (succinyl-transferring) activity
IAO_0000115: Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.
has exact synonym: 2-ketoglutarate dehydrogenase activity
has exact synonym: 2-oxoglutarate dehydrogenase activity
has exact synonym: 2-oxoglutarate: lipoate oxidoreductase activity
has exact synonym: 2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
has exact synonym: 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity
has exact synonym: AKGDH activity
has exact synonym: OGDC activity
has exact synonym: alpha-ketoglutarate dehydrogenase activity
has exact synonym: alpha-ketoglutaric acid dehydrogenase activity
has exact synonym: alpha-ketoglutaric dehydrogenase activity
has exact synonym: alpha-oxoglutarate dehydrogenase activity
has exact synonym: ketoglutaric dehydrogenase activity
has exact synonym: oxoglutarate decarboxylase activity
has exact synonym: oxoglutarate dehydrogenase (lipoamide) activity
has exact synonym: oxoglutarate dehydrogenase activity
type: Class
subclass of: GO_0016624

pantoate-beta-alanine ligase activity
IAO_0000115: Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
has exact synonym: (R)-pantoate:beta-alanine ligase (AMP-forming)
has exact synonym: D-pantoate:beta-alanine ligase (AMP-forming)
has exact synonym: pantothenate synthetase activity
has related synonym: pantoate-activating enzyme activity
has related synonym: pantoic-activating enzyme activity
type: Class
subclass of: GO_0016881

pantothenase activity
IAO_0000115: Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine.
has exact synonym: (R)-pantothenate amidohydrolase activity
has exact synonym: pantothenate amidohydrolase activity
has exact synonym: pantothenate hydrolase activity
type: Class
subclass of: GO_0016811

pantothenate kinase activity
IAO_0000115: Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
has exact synonym: ATP:(R)-pantothenate 4'-phosphotransferase activity
has exact synonym: ATP:pantothenate 4'-phosphotransferase activity
has exact synonym: D-pantothenate kinase activity
has exact synonym: pantothenate kinase (phosphorylating) activity
has exact synonym: pantothenic acid kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016773

pantetheine-phosphate adenylyltransferase activity
IAO_0000115: Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.
has exact synonym: 3'-dephospho-CoA pyrophosphorylase activity
has exact synonym: ATP:pantetheine-4'-phosphate adenylyltransferase activity
has exact synonym: ATP:pantetheine-phosphate adenylyltransferase activity
has exact synonym: PPAT activity
has exact synonym: dephospho-CoA diphosphorylase activity
has exact synonym: dephospho-CoA pyrophosphorylase activity
has exact synonym: dephospho-coenzyme A pyrophosphorylase activity
has exact synonym: pantetheine phosphate adenylyltransferase activity
has exact synonym: phosphopantetheine adenylyltransferase activity
type: Class
subclass of: GO_0070566

peptide alpha-N-acetyltransferase activity
IAO_0000115: Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
has exact synonym: acetyl-CoA:peptide alpha-N-acetyltransferase activity
has exact synonym: acetyl-CoA:peptide nalpha-acetyltransferase activity
has exact synonym: nalpha-acetyltransferase activity
has exact synonym: protein N-terminal acetyltransferase activity
has related synonym: N(alpha)-acetyltransferase activity
has related synonym: NAT activity
has related synonym: amino-terminal amino acid-acetylating enzyme activity
has related synonym: beta-endorphin acetyltransferase activity
has related synonym: peptide acetyltransferase activity
type: Class
subclass of: GO_0034212

peptide-aspartate beta-dioxygenase activity
IAO_0000115: Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2.
has exact synonym: aspartate beta-hydroxylase activity
has exact synonym: aspartylpeptide beta-dioxygenase activity
has exact synonym: peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
has related synonym: aspartyl/asparaginyl beta-hydroxylase activity
type: Class
subclass of: GO_0016706
subclass of: GO_0140096

peptidylamidoglycolate lyase activity
IAO_0000115: Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.
has exact synonym: alpha-hydroxyglycine amidating dealkylase activity
has exact synonym: peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity
has exact synonym: peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)
has exact synonym: peptidylamidoglycolate peptidylamide-lyase activity
has related synonym: HGAD
has related synonym: PAL
has related synonym: PGL
type: Class
subclass of: GO_0016842
subclass of: GO_0140096

obsolete cyclophilin
IAO_0000115: OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity.
type: Class
subclass of: ObsoleteClass

peroxidase activity
IAO_0000115: Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
has exact synonym: donor:hydrogen-peroxide oxidoreductase activity
has exact synonym: oxyperoxidase activity
has exact synonym: peroxidase reaction
has related synonym: MPO
has related synonym: bacterial catalase-peroxidase activity
has related synonym: eosinophil peroxidase activity
has related synonym: extensin peroxidase
has related synonym: guaiacol peroxidase
has related synonym: heme peroxidase
has related synonym: horseradish peroxidase (HRP)
has related synonym: japanese radish peroxidase
has related synonym: lactoperoxidase activity
has related synonym: myeloperoxidase activity
has related synonym: protoheme peroxidase
has related synonym: pyrocatechol peroxidase
has related synonym: scopoletin peroxidase
has related synonym: secretory plant peroxidase activity
has related synonym: thiocyanate peroxidase
has related synonym: verdoperoxidase
replaces: GO_0016685
replaces: GO_0016686
replaces: GO_0016687
replaces: GO_0016693
type: Class
subclass of: GO_0016209
subclass of: GO_0016684

glutathione peroxidase activity
IAO_0000115: Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
has exact synonym: GSH peroxidase activity
has exact synonym: glutathione:hydrogen-peroxide oxidoreductase activity
has exact synonym: reduced glutathione peroxidase activity
has exact synonym: selenium-glutathione peroxidase activity
has related synonym: non-selenium glutathione peroxidase activity
replaces: GO_0016224
type: Class
subclass of: peroxidase activity

phenylethanolamine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
has exact synonym: S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity
has exact synonym: noradrenalin N-methyltransferase activity
has exact synonym: norepinephrine N-methyltransferase activity
has exact synonym: norepinephrine methyltransferase activity
has exact synonym: phenethanolamine N-methyltransferase activity
has exact synonym: phenethanolamine methyltransferase activity
has related synonym: noradrenaline N-methyltransferase activity
type: Class
subclass of: GO_0008170
subclass of: GO_0008757

phosphoadenylyl-sulfate reductase (thioredoxin) activity
IAO_0000115: Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.
has exact synonym: 3'-phosphoadenylylsulfate reductase activity
has exact synonym: PAPS reductase activity
has exact synonym: PAPS reductase, thioredoxin-dependent activity
has exact synonym: PAPS sulfotransferase activity
has exact synonym: PAdoPS reductase activity
has exact synonym: adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
has exact synonym: adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
has exact synonym: phosphoadenosine-phosphosulfate reductase activity
has exact synonym: phosphoadenylyl-sulphate reductase (thioredoxin) activity
has exact synonym: thioredoxin:3'-phospho-adenylylsulfate reductase activity
has exact synonym: thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity
type: Class
subclass of: GO_0016671

phosphatidate cytidylyltransferase activity
IAO_0000115: Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
has exact synonym: CDP diglyceride pyrophosphorylase activity
has exact synonym: CDP-diacylglyceride synthetase activity
has exact synonym: CDP-diacylglycerol synthase activity
has exact synonym: CDP-diglyceride diphosphorylase activity
has exact synonym: CDP-diglyceride pyrophosphorylase activity
has exact synonym: CDP-diglyceride synthase activity
has exact synonym: CDP-diglyceride synthetase activity
has exact synonym: CTP-diacylglycerol synthetase activity
has exact synonym: CTP:1,2-diacylglycerophosphate-cytidyl transferase activity
has exact synonym: CTP:phosphatidate cytidylyltransferase activity
has exact synonym: DAG synthetase activity
has exact synonym: cytidine diphosphoglyceride pyrophosphorylase activity
has exact synonym: phosphatidate cytidyltransferase activity
has exact synonym: phosphatidic acid cytidylyltransferase activity
has related synonym: CDP-DG
type: Class
subclass of: GO_0070567

phosphatidylcholine-sterol O-acyltransferase activity
IAO_0000115: Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
has exact synonym: LCAT activity
has exact synonym: lecithin--cholesterol acyltransferase activity
has exact synonym: lecithin:cholesterol acyltransferase activity
has exact synonym: phosphatidylcholine:sterol O-acyltransferase activity
has exact synonym: phospholipid--cholesterol acyltransferase activity
has related synonym: LCAT (lecithin-cholesterol acyltransferase)
type: Class
subclass of: GO_0008374

phosphatidylethanolamine N-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.
has exact synonym: LMTase activity
has exact synonym: S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity
has exact synonym: lipid methyl transferase activity
has exact synonym: phosphatidylethanolamine methyltransferase activity
has exact synonym: phosphatidylethanolamine-N-methylase activity
has exact synonym: phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity
has related synonym: PEMT
type: Class
subclass of: GO_0008170
subclass of: GO_0008757

phosphatidylserine decarboxylase activity
IAO_0000115: Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine.
has exact synonym: PS decarboxylase activity
has exact synonym: phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)
has exact synonym: phosphatidyl-L-serine carboxy-lyase activity
type: Class
subclass of: GO_0016831

phosphoacetylglucosamine mutase activity
IAO_0000115: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.
has exact synonym: N-acetyl-D-glucosamine 1,6-phosphomutase activity
has exact synonym: N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity
has exact synonym: N-acetylglucosamine-phosphate mutase activity
has exact synonym: acetylaminodeoxyglucose phosphomutase activity
has exact synonym: acetylglucosamine phosphomutase activity
has exact synonym: phospho-N-acetylglucosamine mutase activity
type: Class
subclass of: GO_0016868

phosphoenolpyruvate carboxykinase activity
IAO_0000115: Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.
has exact synonym: PEP carboxykinase activity
has exact synonym: PEPCK activity
has exact synonym: phosphopyruvate carboxylase activity
type: Class
subclass of: GO_0016831

phosphoenolpyruvate carboxykinase (ATP) activity
IAO_0000115: Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate.
has exact synonym: ATP:oxaloacetate carboxy-lyase (transphosphorylating)
has exact synonym: ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
has exact synonym: phosphoenolpyruvate carboxylase (ATP)
has exact synonym: phosphopyruvate carboxykinase (adenosine triphosphate)
has exact synonym: phosphopyruvate carboxylase (ATP)
has related synonym: PEPCK (ATP)
has related synonym: PEPK
has related synonym: phosphoenolpyruvic carboxykinase
has related synonym: phosphopyruvate carboxykinase
type: Class
subclass of: phosphoenolpyruvate carboxykinase activity

phosphoenolpyruvate carboxykinase (GTP) activity
IAO_0000115: Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.
has exact synonym: GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
has exact synonym: GTP:oxaloacetate carboxy-lyase (transphosphorylating)
has exact synonym: phosphoenolpyruvate carboxylase (GTP)
has exact synonym: phosphoenolpyruvic carboxykinase (GTP)
has exact synonym: phosphoenolpyruvic carboxylase (GTP)
has exact synonym: phosphopyruvate (guanosine triphosphate) carboxykinase activity
has exact synonym: phosphopyruvate carboxylase (GTP)
has related synonym: phosphoenolpyruvic carboxykinase
type: Class
subclass of: phosphoenolpyruvate carboxykinase activity

phosphoglucomutase activity
IAO_0000115: Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
has exact synonym: alpha-D-glucose 1,6-phosphomutase activity
has exact synonym: glucose phosphomutase activity
has exact synonym: phosphoglucose mutase activity
type: Class
subclass of: GO_0016868

phosphomannomutase activity
IAO_0000115: Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
has exact synonym: D-mannose 1,6-phosphomutase activity
has exact synonym: alpha-D-mannose 1,6-phosphomutase activity
has exact synonym: mannose phosphomutase activity
has exact synonym: phosphomannose mutase activity
replaces: GO_0008971
type: Class
subclass of: GO_0016868

phosphogluconate dehydrogenase (decarboxylating) activity
IAO_0000115: Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.
has exact synonym: 6-phospho-D-gluconate dehydrogenase activity
has exact synonym: 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
has exact synonym: 6-phosphogluconate dehydrogenase (decarboxylating)
has exact synonym: 6-phosphogluconic carboxylase activity
has exact synonym: 6PGD activity
has exact synonym: phosphogluconic acid dehydrogenase activity
has related synonym: 6-phosphogluconic dehydrogenase activity
type: Class
subclass of: GO_0016616

phosphoglycerate dehydrogenase activity
IAO_0000115: Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
has exact synonym: 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity
has exact synonym: 3-phosphoglycerate dehydrogenase activity
has exact synonym: 3-phosphoglycerate:NAD+ 2-oxidoreductase activity
has exact synonym: 3-phosphoglyceric acid dehydrogenase activity
has exact synonym: 3PHP reductase activity
has exact synonym: D-3-phosphoglycerate dehydrogenase activity
has exact synonym: D-3-phosphoglycerate:NAD+ oxidoreductase activity
has exact synonym: PGDH activity
has exact synonym: SerA 3PG dehydrogenase activity
has exact synonym: alpha-KG reductase activity
has exact synonym: alpha-phosphoglycerate dehydrogenase activity
has exact synonym: alphaKG reductase activity
has exact synonym: glycerate 3-phosphate dehydrogenase activity
has exact synonym: glycerate-1,3-phosphate dehydrogenase activity
has exact synonym: phosphoglycerate oxidoreductase activity
has exact synonym: phosphoglyceric acid dehydrogenase activity
has related synonym: D- and L-HGA
has related synonym: SerA
type: Class
subclass of: GO_0016616

phosphoglycerate kinase activity
IAO_0000115: Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+).
has exact synonym: 3-phosphoglycerate kinase activity
has exact synonym: 3-phosphoglycerate phosphokinase activity
has exact synonym: 3-phosphoglyceric acid kinase activity
has exact synonym: 3-phosphoglyceric acid phosphokinase activity
has exact synonym: 3-phosphoglyceric kinase activity
has exact synonym: ATP-3-phospho-D-glycerate-1-phosphotransferase activity
has exact synonym: ATP:3-phospho-D-glycerate 1-phosphotransferase activity
has exact synonym: ATP:D-3-phosphoglycerate 1-phosphotransferase activity
has exact synonym: glycerate 3-phosphate kinase activity
has exact synonym: glycerophosphate kinase activity
has exact synonym: phosphoglyceric acid kinase activity
has exact synonym: phosphoglyceric kinase activity
has exact synonym: phosphoglycerokinase activity
has related synonym: 3-PGK
has related synonym: PGK
type: Class
subclass of: GO_0016301
subclass of: GO_0016774

phosphoglycerate mutase activity
IAO_0000115: Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
has exact synonym: D-phosphoglycerate 2,3-phosphomutase activity
has exact synonym: PGA mutase activity
has exact synonym: PGAM activity
has exact synonym: PGM
has exact synonym: monophosphoglycerate mutase activity
has exact synonym: monophosphoglyceromutase activity
has exact synonym: phosphoglycerate phosphomutase activity
has exact synonym: phosphoglyceromutase activity
has related synonym: GriP mutase
has related synonym: MPGM
has related synonym: bisphosphoglyceromutase
has related synonym: diphosphoglycomutase
type: Class
subclass of: GO_0016868

phospholipase activity
IAO_0000115: Catalysis of the hydrolysis of a glycerophospholipid.
type: Class
subclass of: GO_0016298

glycosylphosphatidylinositol phospholipase D activity
IAO_0000115: Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.
has exact synonym: GPI-PLD activity
has exact synonym: glycoprotein phospholipase D activity
has exact synonym: glycoprotein-phosphatidylinositol phosphatidohydrolase activity
has exact synonym: phosphatidylinositol phospholipase D activity
has exact synonym: phosphatidylinositol-glycan-specific phospholipase D activity
has exact synonym: phosphatidylinositol-specific phospholipase D activity
type: Class
subclass of: phospholipase D activity

lysophospholipase activity
IAO_0000115: Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
has exact synonym: 2-lysophosphatidylcholine acylhydrolase activity
has exact synonym: lecithinase B activity
has exact synonym: lecitholipase activity
has exact synonym: lysolecithinase activity
has exact synonym: lysophosphatidase activity
has exact synonym: lysophosphatidylcholine hydrolase activity
has exact synonym: phospholipase B activity
has related synonym: lysophopholipase L2
has related synonym: lysophospholipase A1
has related synonym: phosphatidase B
replaces: GO_0045126
type: Class
subclass of: phospholipase activity
subclass of: GO_0052689

phospholipase A2 activity
IAO_0000115: Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
has exact synonym: lecithinase A activity
has exact synonym: phosphatidolipase activity
has exact synonym: phosphatidylcholine 2-acylhydrolase activity
has related synonym: cytosolic phospholipase A2 activity
has related synonym: phosphatidase activity
has related synonym: phospholipase A
has related synonym: secreted phospholipase A2 activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0052689

obsolete secreted phospholipase A2 activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.
type: Class
subclass of: ObsoleteClass

obsolete calcium-dependent secreted phospholipase A2 activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.
type: Class
subclass of: ObsoleteClass

obsolete cytosolic phospholipase A2 activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.
type: Class
subclass of: ObsoleteClass

obsolete calcium-dependent cytosolic phospholipase A2 activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.
type: Class
subclass of: ObsoleteClass

obsolete calcium-independent cytosolic phospholipase A2 activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.
type: Class
subclass of: ObsoleteClass

phospholipase C activity
IAO_0000115: Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
has related synonym: lecithinase C activity
has related synonym: lipophosphodiesterase C
has related synonym: phosphatidase C
replaces: GO_0042298
type: Class
subclass of: phospholipase activity
subclass of: GO_0008081

phospholipase D activity
IAO_0000115: Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.
has exact synonym: choline phosphatase activity
has exact synonym: lecithinase D activity
has exact synonym: lipophosphodiesterase II activity
has exact synonym: phosphatidylcholine phosphatidohydrolase activity
type: Class
subclass of: phospholipase activity
subclass of: GO_0008081

phosphomevalonate kinase activity
IAO_0000115: Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+).
has exact synonym: 5-phosphomevalonate kinase activity
has exact synonym: ATP:(R)-5-phosphomevalonate phosphotransferase activity
has exact synonym: ATP:5-phosphomevalonate phosphotransferase activity
has exact synonym: mevalonate phosphate kinase activity
has exact synonym: mevalonate-5-phosphate kinase activity
has exact synonym: mevalonic acid phosphate kinase activity
type: Class
subclass of: GO_0016301
subclass of: GO_0016776

phosphopantothenate--cysteine ligase activity
IAO_0000115: Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.
has exact synonym: (R)-4'-phosphopantothenate:L-cysteine ligase activity
has exact synonym: phosphopantothenate-cysteine ligase activity
has exact synonym: phosphopantothenoylcysteine synthetase activity
type: Class
subclass of: GO_0016881

phosphopantothenoylcysteine decarboxylase activity
IAO_0000115: Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate.
has exact synonym: 4-phosphopantothenoyl-L-cysteine decarboxylase activity
has exact synonym: 4-phosphopantotheoylcysteine decarboxylase activity
has exact synonym: N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity
has exact synonym: N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)
has exact synonym: N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity
has exact synonym: PPC-decarboxylase activity
type: Class
subclass of: GO_0016831

phosphopyruvate hydratase activity
IAO_0000115: Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.
has exact synonym: 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
has exact synonym: 2-phospho-D-glycerate hydro-lyase activity
has exact synonym: 2-phospho-D-glycerate-hydrolase activity
has exact synonym: 2-phosphoglycerate dehydratase activity
has exact synonym: 2-phosphoglycerate enolase activity
has exact synonym: 2-phosphoglyceric dehydratase activity
has exact synonym: enolase activity
has exact synonym: gamma-enolase activity
has exact synonym: phosphoenolpyruvate hydratase activity
has related synonym: 14-3-2-protein
has related synonym: nervous-system specific enolase
type: Class
subclass of: GO_0016836

phosphoribosyl-AMP cyclohydrolase activity
IAO_0000115: Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.
has exact synonym: 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity
has exact synonym: PRAMP-cyclohydrolase activity
has exact synonym: phosphoribosyladenosine monophosphate cyclohydrolase activity
type: Class
subclass of: GO_0019238

phosphoribosyl-ATP diphosphatase activity
IAO_0000115: Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+).
has exact synonym: 1-(5-phosphoribosyl)-ATP diphosphohydrolase activity
has exact synonym: phosphoribosyl-ATP pyrophosphatase activity
has exact synonym: phosphoribosyladenosine triphosphate pyrophosphatase activity
type: Class
subclass of: GO_0016462

phosphoribosylamine-glycine ligase activity
IAO_0000115: Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate.
has exact synonym: 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity
has exact synonym: 5'-phosphoribosylglycinamide synthetase activity
has exact synonym: 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
has exact synonym: GAR synthetase activity
has exact synonym: GARS activity
has exact synonym: glycinamide ribonucleotide synthetase activity
has exact synonym: glycineamide ribonucleotide synthetase activity
has exact synonym: phosphoribosylglycinamide synthetase activity
has exact synonym: phosphoribosylglycineamide synthetase activity
has related synonym: GAR
type: Class
subclass of: GO_0016879

phosphoribosylaminoimidazole carboxylase activity
IAO_0000115: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
has exact synonym: 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity
has exact synonym: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity
has exact synonym: 5-amino-1-ribosylimidazole 5-phosphate carboxylase activity
has exact synonym: 5-phosphoribosyl-5-aminoimidazole carboxylase activity
has exact synonym: AIR carboxylase activity
has related synonym: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
has related synonym: ADE2
has related synonym: class II PurE
type: Class
subclass of: GO_0016831

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAO_0000115: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.
has exact synonym: 4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity
has exact synonym: 4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity
has exact synonym: 4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity
has exact synonym: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
has exact synonym: 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity
has exact synonym: SAICAR synthase activity
has exact synonym: SAICAR synthetase activity
has exact synonym: SAICARs activity
has exact synonym: phosphoribosylaminoimidazole-succinocarboxamide synthase activity
has exact synonym: phosphoribosylaminoimidazole-succinocarboxamide synthetase activity
has exact synonym: phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity
has related synonym: PurC
type: Class
subclass of: GO_0016881

phosphoribosylanthranilate isomerase activity
IAO_0000115: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
has exact synonym: N-(5'-phosphoribosyl)anthranilate isomerase activity
has exact synonym: N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity
has exact synonym: N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity
has exact synonym: PRA isomerase activity
has exact synonym: PRAI activity
has related synonym: IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)
type: Class
subclass of: GO_0016861

phosphoribosylformylglycinamidine cyclo-ligase activity
IAO_0000115: Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
has exact synonym: 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
has exact synonym: 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
has exact synonym: 5'-aminoimidazole ribonucleotide synthetase activity
has exact synonym: AIR synthase activity
has exact synonym: AIR synthetase activity
has exact synonym: AIRS activity
has exact synonym: phosphoribosyl-aminoimidazole synthetase activity
has exact synonym: phosphoribosylaminoimidazole synthetase activity
type: Class
subclass of: GO_0016882

phosphoribosylformylglycinamidine synthase activity
IAO_0000115: Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.
has exact synonym: 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
has exact synonym: 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
has exact synonym: FGAM synthase activity
has exact synonym: FGAM synthetase activity
has exact synonym: FGAR amidotransferase activity
has exact synonym: FGARAT activity
has exact synonym: N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
has exact synonym: formylglycinamide ribonucloetide amidotransferase activity
has exact synonym: formylglycinamide ribotide amidotransferase activity
has exact synonym: phosphoribosylformylglycinamidine synthetase activity
has exact synonym: phosphoribosylformylglycineamidine synthetase activity
type: Class
subclass of: GO_0016884

phosphoribosylaminoimidazolecarboxamide formyltransferase activity
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
has exact synonym: 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity
has exact synonym: 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity
has exact synonym: 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity
has exact synonym: 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity
has exact synonym: 5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity
has exact synonym: 5-amino-4-imidazolecarboxamide ribotide transformylase activity
has exact synonym: AICAR formyltransferase activity
has exact synonym: AICAR transformylase activity
has exact synonym: aminoimidazolecarboxamide ribonucleotide transformylase activity
type: Class
subclass of: GO_0016742

phosphoribosylglycinamide formyltransferase activity
IAO_0000115: Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
has exact synonym: 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity
has exact synonym: 2-amino-N-ribosylacetamide 5'-phosphate transformylase activity
has exact synonym: 5'-phosphoribosylglycinamide transformylase activity
has exact synonym: 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity
has exact synonym: GAR TFase activity
has exact synonym: GAR formyltransferase activity
has exact synonym: GAR transformylase activity
has exact synonym: GART activity
has exact synonym: glycinamide ribonucleotide transformylase activity
type: Class
subclass of: GO_0016742

1,4-alpha-oligoglucan phosphorylase activity
IAO_0000115: Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.
has exact synonym: 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity
has exact synonym: 1,4-alpha-glucan phosphorylase activity
has exact synonym: polyphosphorylase activity
has related synonym: alpha-glucan phosphorylase
has related synonym: amylopectin phosphorylase
has related synonym: amylophosphorylase activity
has related synonym: glucan phosphorylase
has related synonym: glucosan phosphorylase
has related synonym: granulose phosphorylase
has related synonym: muscle phosphorylase
has related synonym: muscle phosphorylase a and b activity
has related synonym: myophosphorylase
has related synonym: potato phosphorylase
has related synonym: starch phosphorylase
type: Class
subclass of: GO_0016758

phosphoserine phosphatase activity
IAO_0000115: Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate.
has exact synonym: O-phosphoserine phosphohydrolase activity
type: Class
subclass of: GO_0016791

O-phospho-L-serine:2-oxoglutarate aminotransferase activity
IAO_0000115: Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
has exact synonym: 3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity
has exact synonym: 3-phosphoserine aminotransferase activity
has exact synonym: 3PHP transaminase activity
has exact synonym: L-phosphoserine aminotransferase activity
has exact synonym: PSAT activity
has exact synonym: hydroxypyruvic phosphate--glutamic transaminase activity
has exact synonym: phosphohydroxypyruvate transaminase activity
has exact synonym: phosphohydroxypyruvic--glutamic transaminase activity
has related synonym: PdxC
has related synonym: SerC
has related synonym: phosphoserine aminotransferase activity
has related synonym: phosphoserine transaminase activity
replaces: GO_0004646
type: Class
subclass of: GO_0008483

poly(ADP-ribose) glycohydrolase activity
IAO_0000115: Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

polygalacturonase activity
IAO_0000115: Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans.
has exact synonym: endo-D-galacturonase activity
has exact synonym: endo-polygalacturonase activity
has exact synonym: endogalacturonase activity
has exact synonym: endopolygalacturonase activity
has exact synonym: pectin hydrolase activity
has exact synonym: pectin polygalacturonase activity
has exact synonym: pectolase activity
has exact synonym: poly(1,4-alpha-D-galacturonide) glycanohydrolase activity
has exact synonym: poly-alpha-1,4-galacturonide glycanohydrolase activity
has related synonym: pectin depolymerase activity
has related synonym: pectinase activity
type: Class
subclass of: hydrolase activity, hydrolyzing O-glycosyl compounds

polynucleotide 5'-phosphatase activity
IAO_0000115: Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate.
has exact synonym: 5'-polynucleotidase activity
has exact synonym: polynucleotide 5'-phosphohydrolase activity
has exact synonym: polynucleotide 5'-triphosphatase activity
type: Class
subclass of: part-of-parent-98507
subclass of: GO_0098518

polynucleotide adenylyltransferase activity
IAO_0000115: Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
has exact synonym: AMP polynucleotidylexotransferase activity
has exact synonym: ATP-polynucleotide adenylyltransferase activity
has exact synonym: ATP:polynucleotide adenylyltransferase activity
has exact synonym: ATP:polynucleotidylexotransferase activity
has exact synonym: NTP polymerase activity
has exact synonym: RNA adenylating enzyme activity
has exact synonym: adenosine triphosphate:ribonucleic acid adenylyltransferase activity
has exact synonym: poly(A) hydrolase activity
has exact synonym: poly(A) polymerase activity
has exact synonym: poly(A) synthetase activity
has exact synonym: poly-A polymerase activity
has exact synonym: polyadenylate nucleotidyltransferase activity
has exact synonym: polyadenylate polymerase activity
has exact synonym: polyadenylate synthetase activity
has exact synonym: polyadenylic acid polymerase activity
has exact synonym: polyadenylic polymerase activity
has exact synonym: terminal riboadenylate transferase activity
has related synonym: RNA formation factors, PF1
type: Class
subclass of: GO_0070566

polypeptide N-acetylgalactosaminyltransferase activity
IAO_0000115: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.
has exact synonym: UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity
has exact synonym: UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity
has exact synonym: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity
has exact synonym: UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity
has exact synonym: UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
has exact synonym: UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity
has exact synonym: glycoprotein acetylgalactosaminyltransferase activity
has exact synonym: polypeptide-N-acetylgalactosamine transferase activity
has exact synonym: protein-UDP acetylgalactosaminyltransferase activity
has exact synonym: uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
type: Class
subclass of: GO_0008376
subclass of: GO_0140096

polyribonucleotide nucleotidyltransferase activity
IAO_0000115: Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
has exact synonym: nucleoside diphosphate:polynucleotidyl transferase activity
has exact synonym: polynucleotide phosphorylase activity
has exact synonym: polyribonucleotide phosphorylase activity
has exact synonym: polyribonucleotide:phosphate nucleotidyltransferase activity
type: Class
subclass of: GO_0016779

porphobilinogen synthase activity
IAO_0000115: Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen.
has exact synonym: 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)
has exact synonym: 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
has exact synonym: 5-levulinic acid dehydratase activity
has exact synonym: aminolevulinate dehydratase activity
has exact synonym: aminolevulinic dehydratase activity
has exact synonym: delta-aminolevulinate dehydratase activity
has exact synonym: delta-aminolevulinic acid dehydrase activity
has exact synonym: delta-aminolevulinic acid dehydratase activity
has exact synonym: delta-aminolevulinic dehydratase activity
type: Class
subclass of: GO_0016836

procollagen-proline 4-dioxygenase activity
IAO_0000115: Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.
has exact synonym: collagen proline hydroxylase activity
has exact synonym: hydroxylase, collagen proline activity
has exact synonym: procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity
has exact synonym: procollagen-proline,2-oxoglutarate-4-dioxygenase activity
has exact synonym: proline protocollagen hydroxylase activity
has exact synonym: prolylprotocollagen dioxygenase activity
has exact synonym: prolylprotocollagen hydroxylase activity
has exact synonym: protocollagen proline 4-hydroxylase activity
has exact synonym: protocollagen proline dioxygenase activity
has exact synonym: protocollagen proline hydroxylase activity
has exact synonym: protocollagen prolyl hydroxylase activity
has related synonym: peptidyl proline hydroxylase activity
has related synonym: proline hydroxylase activity
has related synonym: proline, 2-oxoglutarate dioxygenase activity
has related synonym: proline,2-oxoglutarate 4-dioxygenase activity
has related synonym: prolyl 4-hydroxylase activity
has related synonym: prolyl hydroxylase activity
has related synonym: prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity
has related synonym: protocollagen hydroxylase activity
type: Class
subclass of: GO_0019798
subclass of: GO_0031545

proline dehydrogenase activity
IAO_0000115: Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
has exact synonym: L-proline dehydrogenase activity
has exact synonym: L-proline:(acceptor) oxidoreductase activity
has exact synonym: L-proline:acceptor oxidoreductase activity
type: Class
subclass of: GO_0016645

propionyl-CoA carboxylase activity
IAO_0000115: Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.
has exact synonym: PCCase activity
has exact synonym: propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
has exact synonym: propionyl coenzyme A carboxylase activity
type: Class
subclass of: GO_0016421

prenyltransferase activity
IAO_0000115: Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).
type: Class
subclass of: GO_0016765

protein farnesyltransferase activity
IAO_0000115: Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
has exact synonym: FTase activity
has exact synonym: farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
has exact synonym: protein-cysteine farnesyltransferase activity
has related synonym: CAAX farnesyltransferase activity
replaces: GO_0018223
type: Class
subclass of: GO_0008318

protein geranylgeranyltransferase activity
IAO_0000115: Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
has exact synonym: protein-cysteine geranylgeranyltransferase activity
replaces: GO_0018224
type: Class
subclass of: GO_0008318

CAAX-protein geranylgeranyltransferase activity
IAO_0000115: Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
has exact synonym: GGTase-I activity
has exact synonym: GGTaseI activity
has exact synonym: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
has exact synonym: geranylgeranyltransferase type I activity
has exact synonym: type I protein geranyl-geranyltransferase activity
has related synonym: protein geranylgeranyltransferase type I
type: Class
subclass of: protein geranylgeranyltransferase activity

Rab geranylgeranyltransferase activity
IAO_0000115: Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
has exact synonym: GGTase-II activity
has exact synonym: GGTaseII activity
has exact synonym: Rab-protein geranylgeranyltransferase activity
has exact synonym: RabGGTase activity
has exact synonym: geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
has exact synonym: protein geranylgeranyltransferase type II activity
has exact synonym: type II protein geranyl-geranyltransferase activity
type: Class
subclass of: protein geranylgeranyltransferase activity

prephenate dehydratase activity
IAO_0000115: Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2.
has exact synonym: prephenate hydro-lyase (decarboxylating)
has exact synonym: prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)
type: Class
subclass of: GO_0016836

prephenate dehydrogenase (NADP+) activity
IAO_0000115: Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH.
has exact synonym: prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity
has exact synonym: prephenate:NADP+ oxidoreductase (decarboxylating)
type: Class
subclass of: GO_0016628

prostaglandin-endoperoxide synthase activity
IAO_0000115: Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
has exact synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
has exact synonym: (PG)H synthase activity
has exact synonym: PG synthetase activity
has exact synonym: fatty acid cyclooxygenase activity
has exact synonym: prostaglandin G/H synthase activity
has exact synonym: prostaglandin endoperoxide synthetase activity
has exact synonym: prostaglandin synthase activity
has exact synonym: prostaglandin synthetase activity
type: Class
subclass of: GO_0016705

prostaglandin-D synthase activity
IAO_0000115: Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
has exact synonym: (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity
has exact synonym: PGD2 synthase activity
has exact synonym: PGH-PGD isomerase activity
has exact synonym: prostaglandin D2 synthase activity
has exact synonym: prostaglandin-H2 D-isomerase activity
has exact synonym: prostaglandin-R-prostaglandin D isomerase activity
type: Class
subclass of: GO_0016860

protein-arginine deiminase activity
IAO_0000115: Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. This reaction is calcium-dependent.
has exact synonym: peptidylarginine deiminase activity
has exact synonym: protein-L-arginine iminohydrolase activity
type: Class
subclass of: GO_0016813

protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
has exact synonym: S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity
has exact synonym: S-farnesylcysteine methyltransferase activity
has exact synonym: farnesyl cysteine C-terminal methyltransferase activity
has exact synonym: farnesyl-protein carboxymethyltransferase activity
has exact synonym: farnesylated protein C-terminal O-methyltransferase activity
has exact synonym: isoprenylated protein methyltransferase activity
has exact synonym: prenylated protein carboxyl methyltransferase activity
has exact synonym: prenylated protein methyltransferase activity
has exact synonym: prenylcysteine carboxylmethyltransferase activity
has exact synonym: prenylcysteine carboxymethyltransferase activity
has exact synonym: prenylcysteine methyltransferase activity
has exact synonym: protein C-terminal farnesylcysteine O-methyltransferase activity
has exact synonym: protein S-farnesylcysteine C-terminal methyltransferase activity
has exact synonym: protein-S-isoprenylcysteine O-methyltransferase activity
has related synonym: isoprenylcysteine carboxylmethyltransferase activity
has related synonym: prenylcysteine carboxyl methyltransferase activity
replaces: GO_0018225
type: Class
subclass of: protein C-terminal carboxyl O-methyltransferase activity
subclass of: GO_0008757

protein kinase activity
IAO_0000115: Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
has related synonym: protamine kinase activity
replaces: GO_0050222
type: Class
subclass of: part-of-parent-6468
subclass of: GO_0016301
subclass of: GO_0016773
subclass of: GO_0140096

protein histidine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
has exact synonym: ATP:protein-L-histidine N-phosphotransferase activity
has exact synonym: histidine kinase (ambiguous)
has exact synonym: histidine kinase activity
has exact synonym: histidine protein kinase (ambiguous)
has exact synonym: histidine protein kinase activity
has exact synonym: protein histidine kinase (ambiguous)
has exact synonym: protein kinase (histidine)
has exact synonym: protein kinase (histidine) (ambiguous)
has exact synonym: protein-histidine kinase activity
has related synonym: EnvZ
has related synonym: HK1
has related synonym: HP165
has related synonym: Sln1p
replaces: GO_0008896
type: Class
subclass of: protein kinase activity
subclass of: part-of-parent-18106
subclass of: GO_0016775

protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
has exact synonym: protein serine-threonine kinase activity
has exact synonym: serine(threonine) protein kinase activity
has exact synonym: serine/threonine protein kinase activity
has related synonym: protein kinase (phosphorylating) activity
has related synonym: protein phosphokinase activity
has related synonym: protein serine kinase activity
has related synonym: protein-serine kinase activity
has related synonym: serine kinase activity
has related synonym: serine protein kinase activity
has related synonym: serine-specific protein kinase activity
has related synonym: threonine-specific protein kinase activity
replaces: GO_0004695
replaces: GO_0004696
replaces: GO_0004700
type: Class
subclass of: protein kinase activity

transmembrane receptor protein serine/threonine kinase activity
IAO_0000115: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
has exact synonym: ATP:receptor-protein phosphotransferase activity
has exact synonym: receptor protein serine/threonine kinase activity
has exact synonym: receptor serine/threonine protein kinase activity
has related synonym: STK13
has related synonym: TGF-beta kinase activity
has related synonym: activin receptor kinase activity
has related synonym: receptor type I serine/threonine protein kinase activity
has related synonym: receptor type II serine/threonine protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: part-of-parent-7178
subclass of: GO_0019199

3-phosphoinositide-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate.
has exact synonym: phosphatidylinositol-3-phosphate protein kinase activity
has related synonym: PDK activity
type: Class
subclass of: protein serine/threonine kinase activity

DNA-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA.
type: Class
subclass of: protein serine/threonine kinase activity

AMP-activated protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
has exact synonym: 5'-AMP-activated protein kinase activity
has related synonym: AMPK activity
has related synonym: SNF1A/AMP-activated protein kinase activity
type: Class
subclass of: protein serine/threonine kinase activity

obsolete casein kinase activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete casein kinase I activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

obsolete protein kinase CK2 activity
IAO_0000115: OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP.
replaces: GO_0008604
type: Class
subclass of: ObsoleteClass

calmodulin-dependent protein kinase activity
IAO_0000115: Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
has exact synonym: ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity
has exact synonym: Ca2+/CaM-dependent kinase activity
has exact synonym: Ca2+/calmodulin-dependent protein kinase activity
has exact synonym: CaM kinase activity
has exact synonym: CaM-regulated serine/threonine kinase activity
has exact synonym: calcium- and calmodulin-dependent protein kinase activity
has exact synonym: calcium/calmodulin-dependent protein kinase activity
has exact synonym: calmodulin regulated protein kinase activity
has related synonym: ATP:caldesmon O-phosphotransferase activity
has related synonym: CAM PKII
has related synonym: Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity
has related synonym: Ca2+/calmodulin-dependent protein kinase 1 activity
has related synonym: Ca2+/calmodulin-dependent protein kinase II activity
has related synonym: Ca2+/calmodulin-dependent protein kinase IV activity
has related synonym: Ca2+/calmodulin-dependent protein kinase kinase activity
has related synonym: Ca2+/calmodulin-dependent protein kinase kinase beta activity
has related synonym: CaM kinase II activity
has related synonym: CaMKI
has related synonym: CaMKII
has related synonym: CaMKIV
has related synonym: CaMKKalpha
has related synonym: CaMKKbeta
has related synonym: STK20
has related synonym: calcium/calmodulin-dependent protein kinase type II activity
has related synonym: caldesmon kinase (phosphorylating) activity
has related synonym: calmodulin-dependent kinase II activity
has related synonym: calmodulin-dependent protein kinase I activity
has related synonym: microtubule-associated protein 2 kinase activity
has related synonym: multifunctional calcium- and calmodulin-regulated protein kinase activity
has related synonym: multifunctional calcium/calmodulin regulated protein kinase activity
replaces: GO_0004684
replaces: GO_0004685
replaces: GO_0004688
type: Class
subclass of: protein serine/threonine kinase activity

elongation factor-2 kinase activity
IAO_0000115: Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate.
has exact synonym: ATP:elongation factor 2 phosphotransferase activity
has exact synonym: Ca/CaM-kinase III activity
has exact synonym: CaM kinase III activity
has exact synonym: calmodulin-dependent protein kinase III activity
has exact synonym: eEF-2 kinase activity
has exact synonym: eEF2 kinase activity
has exact synonym: elongation factor 2 kinase activity
has exact synonym: eukaryotic elongation factor 2 kinase activity
has related synonym: EF2K
has related synonym: STK19
has related synonym: eEF2K
type: Class
subclass of: calmodulin-dependent protein kinase activity

myosin light chain kinase activity
IAO_0000115: Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
has exact synonym: ATP:myosin-light-chain O-phosphotransferase activity
has exact synonym: MLCkase activity
has exact synonym: calcium/calmodulin-dependent myosin light chain kinase activity
has exact synonym: myosin kinase activity
has exact synonym: myosin light chain protein kinase activity
has exact synonym: myosin light-chain kinase (phosphorylating)
has exact synonym: myosin light-chain kinase (phosphorylating) activity
has exact synonym: myosin light-chain kinase activity
has exact synonym: myosin-light-chain kinase activity
has related synonym: ATP:myosin-light-chain O-phosphotransferase
has related synonym: MLCK
has related synonym: STK18
has related synonym: myosin light-chain kinase
has related synonym: smooth-muscle-myosin-light-chain kinase activity
type: Class
subclass of: protein serine/threonine kinase activity

phosphorylase kinase activity
IAO_0000115: Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.
has exact synonym: ATP:phosphorylase-b phosphotransferase activity
has exact synonym: dephosphophosphorylase kinase activity
has exact synonym: glycogen phosphorylase kinase activity
has exact synonym: phosphorylase B kinase activity
has exact synonym: phosphorylase kinase (phosphorylating) activity
has exact synonym: phosphorylase kinase, intrinsic catalyst activity
has related synonym: PHK
has related synonym: STK17
replaces: GO_0008606
type: Class
subclass of: calmodulin-dependent protein kinase activity

cyclic nucleotide-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide.
type: Class
subclass of: protein serine/threonine kinase activity

cAMP-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP.
has exact synonym: 3',5' cAMP-dependent protein kinase activity
has exact synonym: 3',5'-cAMP-dependent protein kinase activity
has exact synonym: ATP:protein phosphotransferase (cAMP-dependent) activity
has exact synonym: adenosine 3',5'-cyclophosphate-dependent protein kinase activity
has exact synonym: cAMP-dependent protein kinase, intrinsic catalyst activity
has exact synonym: cyclic AMP-dependent protein kinase activity
has related synonym: AMPK
has related synonym: PKA
has related synonym: PKA C
has related synonym: STK22
has related synonym: protein kinase A activity
replaces: GO_0008602
type: Class
subclass of: cyclic nucleotide-dependent protein kinase activity

cGMP-dependent protein kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP.
has exact synonym: 3':5'-cyclic GMP-dependent protein kinase activity
has exact synonym: ATP:protein phosphotransferase (cGMP-dependent) activity
has exact synonym: cGMP-dependent protein kinase ibeta activity
has exact synonym: guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity
has related synonym: PKG
has related synonym: PKG 1alpha
has related synonym: PKG 1beta
has related synonym: PKG II
has related synonym: STK23
type: Class
subclass of: cyclic nucleotide-dependent protein kinase activity

cyclin-dependent protein serine/threonine kinase activity
IAO_0000115: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
has exact synonym: ATP:cyclin phosphotransferase activity
has exact synonym: CDK activity
has exact synonym: CDK, catalytic subunit activity
has exact synonym: Cdk-activating protein kinase activity
has exact synonym: cyclin-dependent protein kinase, intrinsic catalyst activity
has related synonym: CDK
has related synonym: D-type cyclin kinase activity
has related synonym: cdc2 kinase activity
has related synonym: cdk-activating kinase activity
has related synonym: cyclin D-cdk6 kinase activity
has related synonym: cyclin D-dependent kinase activity
has related synonym: cyclin E kinase activity
has related synonym: cyclin-A associated kinase activity
has related synonym: cyclin-dependent kinase 6 activity
has related synonym: cyclin-dependent kinase activity
has related synonym: cyclin-dependent kinase-2 activity
has related synonym: cyclin-dependent kinase-4 activity
has related synonym: cyclin-dependent protein kinase activity
has related synonym: neuronal cdc2-like kinase activity
replaces: GO_0016537
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: GO_0097472

eukaryotic translation initiation factor 2alpha kinase activity
IAO_0000115: Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: part-of-parent-10998
subclass of: GO_0045182

protein kinase C activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
has exact synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) activity
has exact synonym: PKC activity
has exact synonym: diacylglycerol-activated phospholipid-dependent PKC activity
has exact synonym: diacylglycerol-activated phospholipid-dependent protein kinase C activity
has related synonym: PKC
has related synonym: PKCalpha
has related synonym: PKCbeta
has related synonym: PKCdelta
has related synonym: PKCepsilon
has related synonym: PKCgamma
has related synonym: PKCzeta
has related synonym: Pkc1p
has related synonym: STK24
has related synonym: cPKC
has related synonym: cPKCalpha
has related synonym: cPKCbeta
has related synonym: cPKCgamma
has related synonym: nPKC
has related synonym: nPKCdelta
has related synonym: nPKCepsilon
has related synonym: nPKCeta
has related synonym: nPKCtheta
has related synonym: protein kinase Cepsilon activity
replaces: GO_0004701
type: Class
subclass of: protein serine/threonine kinase activity

calcium-dependent protein kinase C activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.
has exact synonym: calcium-dependent PKC activity
has exact synonym: conventional protein kinase C activity
type: Class
subclass of: protein kinase C activity
subclass of: GO_0009931

calcium-independent protein kinase C activity
IAO_0000115: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
has exact synonym: calcium-independent PKC activity
has exact synonym: novel protein kinase C activity
type: Class
subclass of: protein kinase C activity

obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity
IAO_0000115: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
type: Class
subclass of: ObsoleteClass

G protein-coupled receptor kinase activity
IAO_0000115: Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
has exact synonym: ATP:G-protein-coupled receptor phosphotransferase activity
has exact synonym: G protein coupled receptor phosphorylating protein kinase activity
has exact synonym: G protein-coupled receptor kinase activity
has exact synonym: G-protein coupled receptor kinase activity
has exact synonym: G-protein-coupled receptor phosphorylating protein kinase activity
has exact synonym: GPCR kinase activity
has exact synonym: GPCR phosphorylating protein kinase activity
has related synonym: GPCRK
has related synonym: GRK4
has related synonym: GRK5
has related synonym: GRK6
has related synonym: STK16
replaces: GO_0004678
type: Class
subclass of: protein serine/threonine kinase activity

NF-kappaB-inducing kinase activity
IAO_0000115: Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK).
has exact synonym: NIK
type: Class
subclass of: part-of-parent-38061
subclass of: GO_0030234

JUN kinase activity
IAO_0000115: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.
has exact synonym: JNK
has related synonym: JNK3alpha1
has related synonym: SAPK1
has related synonym: c-Jun N-terminal kinase activity
type: Class
subclass of: part-of-parent-7258
subclass of: MAP kinase activity

JUN kinase kinase kinase activity
IAO_0000115: Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
has exact synonym: JNKKK
has related synonym: JNK kinase kinase activity
type: Class
subclass of: part-of-parent-7256
subclass of: MAP kinase kinase kinase activity

MAP kinase activity
IAO_0000115: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
has exact synonym: ATP:protein phosphotransferase (MAPKK-activated) activity
has exact synonym: ERK1
has exact synonym: mitogen activated kinase activity
has exact synonym: mitogen-activated protein kinase activity
has related synonym: ERK
has related synonym: ERK2
has related synonym: MAP kinase 1 activity
has related synonym: MAP kinase 2 activity
has related synonym: MAPK
has related synonym: MBP kinase I activity
has related synonym: MBP kinase II activity
has related synonym: SAP kinase activity
has related synonym: SAPK
has related synonym: extracellular signal-regulated kinase activity
has related synonym: myelin basic protein kinase activity
has related synonym: stress-activated kinase activity
has related synonym: stress-activated protein kinase activity
replaces: GO_0008338
replaces: GO_0008339
replaces: GO_0016908
replaces: GO_0016909
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: part-of-parent-165

MAP kinase kinase activity
IAO_0000115: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
has exact synonym: ATP:protein phosphotransferase (MAPKKK-activated) activity
has exact synonym: ERK activator kinase activity
has exact synonym: MAPK activator activity
has exact synonym: MAPKK activity
has exact synonym: mitogen-activated protein kinase kinase activity
has related synonym: MAP kinase kinase 4 activity
has related synonym: MAP kinase kinase 7 activity
has related synonym: MAP kinase or ERK kinase activity
has related synonym: MAP2K
has related synonym: MAPKK
has related synonym: MAPKK1
has related synonym: MEK activity
has related synonym: MEK1
has related synonym: MEK2
has related synonym: MKK
has related synonym: MKK2
has related synonym: MKK4
has related synonym: MKK6
has related synonym: MKK7
has related synonym: STK27
type: Class
subclass of: part-of-parent-165
subclass of: part-of-parent-187
subclass of: protein serine/threonine/tyrosine kinase activity

MAP kinase kinase kinase activity
IAO_0000115: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
has exact synonym: ATP:protein phosphotransferase (MAPKKKK-activated) activity
has exact synonym: MAPK/ERK kinase kinase activity
has exact synonym: MAPKKK activity
has exact synonym: MEK kinase activity
has exact synonym: MEKK activity
has exact synonym: mitogen-activated protein kinase kinase kinase activity
has related synonym: MAP3K
has related synonym: MEKK
has related synonym: MEKK1
has related synonym: MEKK2
has related synonym: MEKK3
has related synonym: MLK-like mitogen-activated protein triple kinase activity
has related synonym: MLTK
has related synonym: MLTKa
has related synonym: MLTKb
has related synonym: Mil/Raf
has related synonym: REKS
has related synonym: STK28
has related synonym: cMos
has related synonym: cRaf
replaces: GO_0004710
type: Class
subclass of: protein serine/threonine kinase activity
subclass of: part-of-parent-165
subclass of: part-of-parent-186

ribosomal protein S6 kinase activity
IAO_0000115: Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
type: Class
subclass of: protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity
IAO_0000115: Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
has exact synonym: ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity
has related synonym: ADK1
has related synonym: Arabidopsis dual specificity kinase 1 activity
has related synonym: CLK1
has related synonym: Mps1p
has related synonym: dDYRK2
has related synonym: dual-specificity kinase activity
has related synonym: dual-specificity protein kinase
has related synonym: protein threonine/tyrosine kinase activity
type: Class
subclass of: protein kinase activity

protein tyrosine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
has exact synonym: protein-tyrosine kinase activity
has related synonym: JAK
has related synonym: Janus kinase activity
replaces: GO_0004718
type: Class
subclass of: protein kinase activity
subclass of: part-of-parent-18108

transmembrane receptor protein tyrosine kinase activity
IAO_0000115: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
has exact synonym: ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity
has exact synonym: receptor protein tyrosine kinase activity
has exact synonym: receptor protein-tyrosine kinase activity
has related synonym: ATP:protein-tyrosine O-phosphotransferase activity
has related synonym: Drosophila Eph kinase activity
has related synonym: anaplastic lymphoma kinase activity
has related synonym: ephrin-B3 receptor tyrosine kinase activity
has related synonym: insulin receptor protein-tyrosine kinase activity
has related synonym: neurite outgrowth regulating kinase activity
has related synonym: neurotrophin TRK receptor activity
has related synonym: neurotrophin TRKA receptor activity
has related synonym: neurotrophin TRKB receptor activity
has related synonym: neurotrophin TRKC receptor activity
has related synonym: novel oncogene with kinase-domain activity
has related synonym: sevenless receptor activity
type: Class
subclass of: protein tyrosine kinase activity
subclass of: GO_0019199

non-membrane spanning protein tyrosine kinase activity
IAO_0000115: Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
has exact synonym: ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity
has exact synonym: non-specific protein-tyrosine kinase activity
has related synonym: ATP:protein-tyrosine O-phosphotransferase activity
has related synonym: Bruton's tyrosine kinase activity
has related synonym: cytoplasmic protein tyrosine kinase activity
has related synonym: focal adhesion kinase activity
has related synonym: janus kinase 1 activity
has related synonym: janus kinase 2 activity
has related synonym: janus kinase 3 activity
has related synonym: p60c-src protein tyrosine kinase activity
type: Class
subclass of: protein tyrosine kinase activity

obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity
IAO_0000115: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
type: Class
subclass of: ObsoleteClass

obsolete focal adhesion kinase activity
IAO_0000115: OBSOLETE. (Was not defined before being made obsolete).
type: Class
subclass of: ObsoleteClass

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
IAO_0000115: Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.
has exact synonym: D-aspartyl/L-isoaspartyl methyltransferase activity
has exact synonym: L-aspartyl/L-isoaspartyl protein methyltransferase activity
has exact synonym: L-isoaspartyl protein carboxyl methyltransferase activity
has exact synonym: L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity
has exact synonym: S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity
has exact synonym: protein (D-aspartate) methyltransferase activity
has exact synonym: protein D-aspartate methyltransferase activity
has exact synonym: protein L-isoaspartate methyltransferase activity
has exact synonym: protein L-isoaspartyl methyltransferase activity
has exact synonym: protein O-methyltransferase (L-isoaspartate)
has exact synonym: protein beta-aspartate O-methyltransferase activity
has exact synonym: protein-L-isoaspartate O-methyltransferase activity
has exact synonym: protein-L-isoaspartate(D-aspartate) O-methyltransferase activity
has exact synonym: protein-beta-aspartate O-methyltransferase activity
type: Class
subclass of: GO_0008757
subclass of: GO_0051998

protein-lysine 6-oxidase activity
IAO_0000115: Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.
has exact synonym: lysyl oxidase activity
has exact synonym: protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
replaces: GO_0018056
type: Class
subclass of: GO_0016641
subclass of: GO_0140096

phosphoprotein phosphatase activity
IAO_0000115: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
has exact synonym: phosphoprotein phosphohydrolase activity
has exact synonym: protein phosphatase activity
has related synonym: protein phosphatase-1 activity
has related synonym: protein phosphatase-2A activity
has related synonym: protein phosphatase-2B activity
has related synonym: protein phosphatase-2C activity
type: Class
subclass of: part-of-parent-6470
subclass of: GO_0016791
subclass of: GO_0140096

protein serine/threonine phosphatase activity
IAO_0000115: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
has exact synonym: serine/threonine specific protein phosphatase activity
has related synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
has related synonym: Aspergillus awamori acid protein phosphatase
has related synonym: BCKDH phosphatase
has related synonym: HMG-CoA reductase phosphatase
has related synonym: branched-chain alpha-keto acid dehydrogenase phosphatase
has related synonym: calcineurin
has related synonym: casein phosphatase
has related synonym: phosphatase 2A
has related synonym: phosphatase 2B
has related synonym: phosphatase C-II
has related synonym: phosphatase H-II
has related synonym: phosphatase I
has related synonym: phosphatase IB
has related synonym: phosphatase II
has related synonym: phosphatase III
has related synonym: phosphatase IV
has related synonym: phosphatase SP
has related synonym: phosphopyruvate dehydrogenase phosphatase
has related synonym: phosphospectrin phosphatase
has related synonym: polycation modulated (PCM-) phosphatase
has related synonym: protein D phosphatase
has related synonym: protein phosphatase X
has related synonym: protein phosphatase type 1 activity
has related synonym: protein phosphatase type 1, intrinsic catalyst activity
has related synonym: protein phosphatase type 2A activity
has related synonym: protein phosphatase type 2A, intrinsic catalyst activity
has related synonym: protein phosphatase type 2B activity
has related synonym: protein phosphatase type 2B, intrinsic catalyst activity
has related synonym: protein phosphatase type 2C activity
has related synonym: protein phosphatase type 4 activity
has related synonym: protein phosphatase type 4, intrinsic catalyst activity
replaces: GO_0000158
replaces: GO_0000163
replaces: GO_0008598
replaces: GO_0008600
replaces: GO_0015071
replaces: GO_0030357
replaces: GO_0030358
replaces: GO_0030360
replaces: GO_0030361
type: Class
subclass of: phosphoprotein phosphatase activity

calcium-dependent protein serine/threonine phosphatase activity
IAO_0000115: Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
has exact synonym: calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity
has related synonym: calcineurin
replaces: GO_0008596
type: Class
subclass of: protein serine/threonine phosphatase activity

magnesium-dependent protein serine/threonine phosphatase activity
IAO_0000115: Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium.
type: Class
subclass of: protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity
IAO_0000115: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
has exact synonym: PPT-phosphatase activity
has exact synonym: PTP-phosphatase activity
has exact synonym: PTPase activity
has exact synonym: [phosphotyrosine]protein phosphatase activity
has exact synonym: phosphoprotein phosphatase (phosphotyrosine) activity
has exact synonym: phosphotyrosine histone phosphatase activity
has exact synonym: phosphotyrosine phosphatase activity
has exact synonym: phosphotyrosine protein phosphatase activity
has exact synonym: phosphotyrosylprotein phosphatase activity
has exact synonym: protein phosphotyrosine phosphatase activity
has exact synonym: protein-tyrosine-phosphatase activity
has exact synonym: protein-tyrosine-phosphate phosphohydrolase activity
has exact synonym: tyrosine O-phosphate phosphatase activity
has exact synonym: tyrosylprotein phosphatase activity
type: Class
subclass of: phosphoprotein phosphatase activity
subclass of: part-of-parent-35335

non-membrane spanning protein tyrosine phosphatase activity
IAO_0000115: Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
type: Class
subclass of: protein tyrosine phosphatase activity