MYCID27.html
type: Resource
comment: Atlas of Genetics and Cytogenetics in Oncology and Haematology

myc
type: Resource
comment: NIEHS-SNPs

R-HSA-1362277
database: Reactome
type: Resource
comment: Transcription of E2F targets under negative control by DREAM complex

R-HSA-2122947
database: Reactome
type: Resource
comment: NOTCH1 Intracellular Domain Regulates Transcription

R-HSA-2173796
database: Reactome
type: Resource
comment: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

R-HSA-2644606
database: Reactome
type: Resource
comment: Constitutive Signaling by NOTCH1 PEST Domain Mutants

R-HSA-2894862
database: Reactome
type: Resource
comment: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

R-HSA-4411364
database: Reactome
type: Resource
comment: Binding of TCF/LEF:CTNNB1 to target gene promoters

R-HSA-5687128
database: Reactome
type: Resource
comment: MAPK6/MAPK4 signaling

R-HSA-5689880
database: Reactome
type: Resource
comment: Ub-specific processing proteases

R-HSA-6785807
database: Reactome
type: Resource
comment: Interleukin-4 and Interleukin-13 signaling

R-HSA-69202
database: Reactome
type: Resource
comment: Cyclin E associated events during G1/S transition

R-HSA-69656
database: Reactome
type: Resource
comment: Cyclin A:Cdk2-associated events at S phase entry

R-HSA-8866911
database: Reactome
type: Resource
comment: TFAP2 (AP-2) family regulates transcription of cell cycle factors

R-HSA-8951430
database: Reactome
type: Resource
comment: RUNX3 regulates WNT signaling

R-HSA-9018519
database: Reactome
type: Resource
comment: Estrogen-dependent gene expression

CAR_000033
range: 22570985973626414tt58tt58
type: Glycosylation Annotation
comment: O-linked (GlcNAc) threonine; alternate

PRO_0000127293
range: 22570985973626414tt1tt439
type: Chain Annotation
comment: Myc proto-oncogene protein

VAR_016327
range: 22570985973626414tt11tt11
substitution: S
type: Natural Variant Annotation

VAR_016328
range: 22570985973626414tt160tt160
substitution: C
type: Natural Variant Annotation

VAR_016329
range: 22570985973626414tt170tt170
substitution: I
type: Natural Variant Annotation

VAR_016330
range: 22570985973626414tt322tt322
substitution: V
type: Natural Variant Annotation

VAR_063384
range: 22570985973626414tt39tt39
substitution: D
type: Natural Variant Annotation
comment: In a Burkitt lymphoma symple.

VAR_063385
range: 22570985973626414tt57tt57
substitution: S
type: Natural Variant Annotation
comment: In a Burkitt lymphoma sample.

VAR_063386
range: 22570985973626414tt59tt59
substitution: A
type: Natural Variant Annotation
comment: In a Burkitt lymphoma sample.

VAR_063387
range: 22570985973626414tt86tt86
substitution: T
type: Natural Variant Annotation
comment: In a Burkitt lymphoma sample.

VSP_037813
range: 22570985973626414tt1tt1
substitution: MDFFRVVENQQPPATM
type: Alternative Sequence Annotation
comment: In isoform 2.

ENSG00000136997
database: Bgee
type: Resource
comment: Expressed in 216 organ(s), highest expression level in thoracic mammary gland

http://purl.uniprot.org/biogrid/110694
database: BioGrid
type: Resource
comment: 668

cd00083
database: CDD
signature sequence match: CDD cd00083 match 1
type: Resource
comment: HLH

MYC
database: ChiTaRS
type: Resource
comment: human

http://purl.uniprot.org/citations/14702039
author: Abe K.
author: Aotsuka S.
author: Arita M.
author: Chiba Y.
author: Fujii Y.
author: Fujimori K.
author: Fujimori Y.
author: Fujiwara T.
author: Fukuzumi Y.
author: Furuya T.
author: Goto Y.
author: Hara H.
author: Hara R.
author: Hata H.
author: Hayashi K.
author: Hikiji T.
author: Hirao M.
author: Hiraoka S.
author: Hishigaki H.
author: Hosoiri T.
author: Hotuta T.
author: Ichihara T.
author: Ikema Y.
author: Imose N.
author: Inagaki H.
author: Irie R.
author: Ishibashi T.
author: Ishida S.
author: Ishii S.
author: Isogai T.
author: Isono Y.
author: Itakura S.
author: Itoh T.
author: Iwayanagi T.
author: Kaku Y.
author: Kamihara K.
author: Kanda K.
author: Kanehori K.
author: Katsuta N.
author: Kawabata A.
author: Kawai Y.
author: Kawakami B.
author: Kawakami T.
author: Kikkawa E.
author: Kikuchi H.
author: Kimata M.
author: Kimura K.
author: Kobatake N.
author: Kodaira H.
author: Komai F.
author: Komatsu T.
author: Komiyama M.
author: Kondo H.
author: Kumagai A.
author: Kusano J.
author: Makita H.
author: Masuho Y.
author: Matsumura K.
author: Matsunawa H.
author: Mizoguchi H.
author: Mizuno T.
author: Mizushima-Sugano J.
author: Momiyama H.
author: Morinaga M.
author: Moriya S.
author: Murakami K.
author: Murakawa K.
author: Musashino K.
author: Nagahari K.
author: Nagai K.
author: Nagase T.
author: Nakagawa K.
author: Nakagawa S.
author: Nakai K.
author: Nakajima Y.
author: Nakamura Y.
author: Nakamura Y.'
author: Ninomiya K.
author: Nishi T.
author: Nishikawa T.

http://purl.uniprot.org/citations/15103331
author: Hatakeyama S.
author: Imaki H.
author: Ishida N.
author: Kamura T.
author: Nakayama K.
author: Nakayama K.I.
author: Nishiyama M.
author: Okumura F.
author: Tsunematsu R.
author: Yada M.
date: 2004
name: EMBO J.
pages: 2116-2125
title: Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
volume: 23
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/15103331

http://purl.uniprot.org/citations/15489334
date: 2004
group: The MGC Project Team
name: Genome Res.
pages: 2121-2127
title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
volume: 14
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/15489334

http://purl.uniprot.org/citations/15674325
author: Austen M.
author: Cerni C.
author: Groetzinger J.
author: Kraft R.
author: Kremmer E.
author: Lesniewicz K.
author: Luescher B.
author: Luescher-Firzlaff J.
author: Mehraein Y.
author: Mertsching J.
author: Poreba E.
author: Schamberger C.
author: Schreek S.
author: Vervoorts J.
author: Walsemann G.
author: Yu M.
date: 2005
name: Oncogene
pages: 1982-1993
title: PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
volume: 24
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/15674325

http://purl.uniprot.org/citations/15723054
author: Eisenman R.N.
author: Felton-Edkins Z.A.
author: Galloway D.A.
author: Gomez-Roman N.
author: Grandori C.
author: Ngouenet C.
author: White R.J.
date: 2005
name: Nat. Cell Biol.
pages: 311-318
title: c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.
volume: 7
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/15723054

http://purl.uniprot.org/citations/1597196
author: Date T.
author: Iijima S.
author: Teraoka H.
author: Tsukada K.
date: 1992
name: Eur. J. Biochem.
pages: 595-603
title: DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein.
volume: 206
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/1597196

http://purl.uniprot.org/citations/16126174
author: Faiola F.
author: Martinez E.
author: Zhang K.
date: 2005
name: Biochem. Biophys. Res. Commun.
pages: 274-280
title: Six lysine residues on c-Myc are direct substrates for acetylation by p300.
volume: 336
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/16126174

http://purl.uniprot.org/citations/16421571
author: Allen N.R.
author: Anderson S.
author: Asakawa S.
author: Asakawa T.
author: Birren B.W.
author: Blechschmidt K.
author: Bloom T.
author: Borowsky M.L.
author: Butler J.
author: Chang J.L.
author: Cook A.
author: Corum B.
author: Cuomo C.A.
author: DeArellano K.
author: DeCaprio D.
author: Dewar K.
author: Dooley K.T.
author: Dorris L. III
author: Engels R.
author: FitzGerald M.G.
author: Garber M.
author: Gloeckner G.
author: Hafez N.
author: Hagopian D.S.
author: Hall J.L.
author: Ishikawa S.K.
author: Jaffe D.B.
author: Kamat A.
author: Kodira C.D.
author: Kudoh J.
author: Lander E.S.
author: Lehmann R.
author: Lokitsang T.
author: Macdonald P.
author: Major J.E.
author: Matthews C.D.
author: Mauceli E.
author: Menzel U.
author: Mihalev A.H.
author: Mikkelsen T.S.
author: Minoshima S.
author: Murayama Y.
author: Naylor J.W.
author: Nguyen C.
author: Nicol R.
author: Nusbaum C.
author: O'Leary S.B.
author: O'Neill K.
author: Parker S.C.J.
author: Platzer M.
author: Polley A.
author: Raymond C.K.
author: Reichwald K.
author: Rodriguez J.
author: Rosenthal A.
author: Sasaki T.
author: Schilhabel M.
author: Schueler M.G.
author: Shimizu A.
author: Shimizu N.
author: Siddiqui R.
author: Smith C.L.
author: Sneddon T.P.
author: Talamas J.A.
author: Taudien S.
author: Tenzin P.
author: Topham K.
author: Venkataraman V.
author: Wen G.
author: Whittaker C.A.
author: Yamazaki S.
author: Yang X.
author: Young S.K.
author: Zeng Q.
author: Zimmer A.R.
author: Zody M.C.
date: 2006
name: Nature
pages: 331-335
title: DNA sequence and analysis of human chromosome 8.

http://purl.uniprot.org/citations/17081983
author: Blagoev B.
author: Gnad F.
author: Kumar C.
author: Macek B.
author: Mann M.
author: Mortensen P.
author: Olsen J.V.
date: 2006
name: Cell
pages: 635-648
title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
volume: 127
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/17081983

http://purl.uniprot.org/citations/17308053
author: Daigo Y.
author: Hayama S.
author: Ishikawa N.
author: Ito T.
author: Kato T.
author: Nakamura Y.
author: Suzuki C.
author: Takahashi K.
author: Tsuchiya E.
date: 2007
name: Mol. Cancer Ther.
pages: 542-551
title: Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.
volume: 6
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/17308053

http://purl.uniprot.org/citations/17311883
author: Carlos L.
author: Eisenman R.N.
author: Li L.
author: Secombe J.
date: 2007
name: Genes Dev.
pages: 537-551
title: The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.
volume: 21
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/17311883

http://purl.uniprot.org/citations/17558397
author: Beijersbergen R.
author: Bernards R.
author: Eilers M.
author: Elledge S.J.
author: Madiredjo M.
author: Moll R.
author: Popov N.
author: Wanzel M.
author: Zhang D.
date: 2007
name: Nat. Cell Biol.
pages: 765-774
title: The ubiquitin-specific protease USP28 is required for MYC stability.
volume: 9
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/17558397

http://purl.uniprot.org/citations/17632056
author: Ahola R.
author: Ala-Aho R.
author: Arnold H.
author: Boettzauw T.
author: Chan E.K.L.
author: Grenman R.
author: Ivaska J.
author: Junttila M.R.
author: Kaehaeri V.-M.
author: Kallunki T.
author: Kast J.
author: Lin S.
author: Lu S.-L.
author: Nielsen C.
author: Niemelae M.
author: Puustinen P.
author: Sears R.
author: Taya Y.
author: Wang X.-J.
author: Westermarck J.
date: 2007
name: Cell
pages: 51-62
title: CIP2A inhibits PP2A in human malignancies.
volume: 130
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/17632056

http://purl.uniprot.org/citations/17873522
author: Eilers M.
author: Herold S.
author: Llamazares M.
author: Popov N.
author: Schulein C.
date: 2007
name: Cell Cycle
pages: 2327-2331
title: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.
volume: 6
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/17873522

http://purl.uniprot.org/citations/18035408
author: Ichisaka T.
author: Narita M.
author: Ohnuki M.
author: Takahashi K.
author: Tanabe K.
author: Tomoda K.
author: Yamanaka S.
date: 2007
name: Cell
pages: 861-872
title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
volume: 131
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/18035408

http://purl.uniprot.org/citations/18669648
author: Bakalarski C.E.
author: Beausoleil S.A.
author: Dephoure N.
author: Elledge S.J.
author: Gygi S.P.
author: Villen J.
author: Zhou C.
date: 2008
name: Proc. Natl. Acad. Sci. U.S.A.
pages: 10762-10767
title: A quantitative atlas of mitotic phosphorylation.
volume: 105
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/18669648

http://purl.uniprot.org/citations/19413330
author: Gauci S.
author: Heck A.J.
author: Helbig A.O.
author: Krijgsveld J.
author: Mohammed S.
author: Slijper M.
date: 2009
name: Anal. Chem.
pages: 4493-4501
title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
volume: 81
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/19413330

http://purl.uniprot.org/citations/19608861
author: Choudhary C.
author: Gnad F.
author: Kumar C.
author: Mann M.
author: Nielsen M.L.
author: Olsen J.V.
author: Rehman M.
author: Walther T.C.
date: 2009
name: Science
pages: 834-840
title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
volume: 325
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/19608861

http://purl.uniprot.org/citations/19966300
author: Bahram F.
author: Grandien A.
author: Hein N.
author: Henriksson M.
author: Hoegstrand K.
author: Hydbring P.
author: Larsson L.-G.
author: Lilischkis R.
author: Luescher B.
author: Sharifi H.R.
author: Su Y.
author: Tronnersjoe S.
author: Vervoorts J.
author: Wu S.
author: von der Lehr N.
date: 2010
name: Proc. Natl. Acad. Sci. U.S.A.
pages: 58-63
title: Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
volume: 107
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/19966300

http://purl.uniprot.org/citations/20068231
author: Brunak S.
author: Cox J.
author: Gnad F.
author: Jensen L.J.
author: Jensen T.S.
author: Kumar C.
author: Mann M.
author: Miller M.L.
author: Nigg E.A.
author: Olsen J.V.
author: Santamaria A.
author: Vermeulen M.
date: 2010
name: Sci. Signal.
pages: RA3
title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
volume: 3
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/20068231

http://purl.uniprot.org/citations/20551172
author: Choi S.H.
author: Cole M.D.
author: Gerber S.A.
author: Wright J.B.
date: 2010
name: Genes Dev.
pages: 1236-1241
title: Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.
volume: 24
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/20551172

http://purl.uniprot.org/citations/2069907
author: Archimbaud E.
author: Charrin C.
author: Gadoux M.
author: Gentilhomme O.
author: Germain D.
author: Lafage M.
author: Rimokh R.
author: Rouault J.P.
author: Samarut J.
author: Wahbi K.
date: 1991
name: Genes Chromosomes Cancer
pages: 24-36
title: A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.
volume: 3
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/2069907

http://purl.uniprot.org/citations/20713526
author: Hydbring P.
author: Larsson L.-G.
date: 2010
name: Cancer Res.
pages: 6687-6691
title: Tipping the balance: Cdk2 enables Myc to suppress senescence.
volume: 70
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/20713526

http://purl.uniprot.org/citations/21406692
author: Akimov V.
author: Blagoev B.
author: Henningsen J.
author: Johansen P.T.
author: Kassem M.
author: Kratchmarova I.
author: Mann M.
author: Olsen J.V.
author: Prokhorova T.A.
author: Rigbolt K.T.
date: 2011
name: Sci. Signal.
pages: RS3
title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
volume: 4
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/21406692

http://purl.uniprot.org/citations/2166998
author: Magrath I.
date: 1990
name: Adv. Cancer Res.
pages: 133-270
title: The pathogenesis of Burkitt's lymphoma.
volume: 55
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/2166998

http://purl.uniprot.org/citations/22307329
author: Kitagawa M.
author: Kurata M.
author: Miki Y.
author: Mimoto R.
author: Taira N.
author: Yamaguchi T.
author: Yoshida K.
date: 2012
name: J. Clin. Invest.
pages: 859-872
title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
volume: 122
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/22307329

http://purl.uniprot.org/citations/23186163
author: Di Palma S.
author: Heck A.J.
author: Mohammed S.
author: Peng M.
author: Polat A.N.
author: Preisinger C.
author: Zhou H.
date: 2013
name: J. Proteome Res.
pages: 260-271
title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
volume: 12
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/23186163

http://purl.uniprot.org/citations/24940000
author: Fu G.
author: Kishi S.
author: Mo Z.
author: Shi Y.
author: Wang G.S.
author: Xu X.
author: Yang X.L.
author: Zhang Q.
date: 2014
name: Elife
pages: E02349
title: tRNA synthetase counteracts c-Myc to develop functional vasculature.
volume: 3
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/24940000

http://purl.uniprot.org/citations/25775507
author: Dai M.S.
author: He X.
author: Komada M.
author: Sears R.C.
author: Sun X.X.
author: Yin L.
date: 2015
name: Proc. Natl. Acad. Sci. U.S.A.
pages: 3734-3739
title: The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.
volume: 112
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/25775507

http://purl.uniprot.org/citations/25956029
author: Cho Y.E.
author: Kim J.Y.
author: Park J.H.
date: 2015
name: Am. J. Pathol.
pages: 2061-2068
title: The nucleolar protein GLTSCR2 is an upstream negative regulator of the oncogenic Nucleophosmin-MYC axis.
volume: 185
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/25956029

http://purl.uniprot.org/citations/28112733
author: Hendriks I.A.
author: Jensen L.J.
author: Lyon D.
author: Nielsen M.L.
author: Vertegaal A.C.
author: Young C.
date: 2017
name: Nat. Struct. Mol. Biol.
pages: 325-336
title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
volume: 24
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/28112733

http://purl.uniprot.org/citations/3540591
author: Bentley D.L.
author: Groudine M.
date: 1986
name: Mol. Cell. Biol.
pages: 3481-3489
title: Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.
volume: 6
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/3540591

http://purl.uniprot.org/citations/6298632
author: Chen E.Y.
author: Colby W.W.
author: Levinson A.D.
author: Smith D.H.
date: 1983
name: Nature
pages: 722-725
title: Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29.
volume: 301
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6298632

http://purl.uniprot.org/citations/6304538
author: Croce C.M.
author: Gallo R.C.
author: Marcu K.B.
author: Rovera G.
author: Stanton L.W.
author: Watt R.
date: 1983
name: Nature
pages: 725-728
title: Nucleotide sequence of cloned cDNA of human c-myc oncogene.
volume: 303
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6304538

http://purl.uniprot.org/citations/6304729
author: Dalla-Favera R.
author: Papas T.S.
author: Psallidopoulos M.C.
author: Samuel K.P.
author: Watson D.K.
date: 1983
name: Proc. Natl. Acad. Sci. U.S.A.
pages: 3642-3645
title: Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product.
volume: 80
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6304729

http://purl.uniprot.org/citations/6321164
author: Adams J.M.
author: Bernard O.
author: Cory S.
author: Gerondakis S.
author: Webb E.
date: 1983
name: EMBO J.
pages: 2375-2383
title: Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
volume: 2
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6321164

http://purl.uniprot.org/citations/6414718
author: Battey J.
author: Leder P.
author: Lenoir G.
author: Moulding C.
author: Murphy W.
author: Potter H.
author: Stewart T.
author: Taub R.
date: 1983
name: Cell
pages: 779-787
title: The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma.
volume: 34
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6414718

http://purl.uniprot.org/citations/6419122
author: Baer R.
author: Hamlyn P.H.
author: Rabbitts T.H.
date: 1983
name: Nature
pages: 760-765
title: Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.
volume: 306
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6419122

http://purl.uniprot.org/citations/6547209
author: Baer R.
author: Forster A.
author: Hamlyn P.
author: Rabbitts T.H.
date: 1984
name: Nature
pages: 592-597
title: Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.
volume: 309
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6547209

http://purl.uniprot.org/citations/6714223
author: Dupont S.
author: Galibert F.
author: Gazin C.
author: Hampe A.
author: Martin P.
author: Masson J.-M.
author: Stehelin D.
author: de Dinechin D.
date: 1984
name: EMBO J.
pages: 383-387
title: Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.
volume: 3
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/6714223

http://purl.uniprot.org/citations/7642555
author: Chou T.-Y.
author: Dang C.V.
author: Hart G.W.
date: 1995
name: J. Biol. Chem.
pages: 18961-18965
title: c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas.
volume: 270
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/7642555

http://purl.uniprot.org/citations/8220424
author: Bhatia K.
author: Huppi K.
author: Iyer R.
author: Magrath I.
author: Siwarski D.
author: Spangler G.
date: 1993
name: Nat. Genet.
pages: 56-61
title: Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
volume: 5
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/8220424

http://purl.uniprot.org/citations/8386367
author: Davis R.J.
author: Gupta S.
author: Seth A.
date: 1993
name: Proc. Natl. Acad. Sci. U.S.A.
pages: 3216-3220
title: Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.
volume: 90
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/8386367

http://purl.uniprot.org/citations/8444346
author: Kato S.
author: Matsuo K.
author: Ohyama K.
author: Tachibana K.
author: Takano T.
author: Takayama N.
author: Umezawa A.
author: Yamamoto K.
date: 1993
name: Gene
pages: 231-237
title: Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.
volume: 124
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/8444346

http://purl.uniprot.org/citations/9315742
author: Alexandrov I.
author: Alexandrova N.
author: Shlyakhova L.
author: Vartanian A.
author: Zajac-Kaye M.
date: 1997
name: FEBS Lett.
pages: 465-470
title: c-Raf kinase binds to N-terminal domain of c-Myc.
volume: 414
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/9315742

http://purl.uniprot.org/citations/9680483
author: Crump M.P.
author: Gagne S.M.
author: Hodges R.S.
author: Kay C.M.
author: Lavigne P.
author: Sykes B.D.
date: 1998
name: J. Mol. Biol.
pages: 165-181
title: Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.
volume: 281
type: Journal Citation
primary topic of: https://www.ncbi.nlm.nih.gov/pubmed/9680483

SIP8453E82A0A33265A
author: Adams M.D.
author: Bolanos R.
author: Clark A.G.
author: Delcher A.L.
author: Dew I.
author: Edwards N.J.
author: Eichler E.E.
author: Fasulo D.
author: Flanigan M.J.
author: Florea L.
author: Halldorsson B.V.
author: Halpern A.L.
author: Hannenhalli S.
author: Hunkapiller M.W.
author: Huson D.H.
author: Istrail S.
author: Kravitz S.A.
author: Lippert R.
author: Lu F.
author: Miller J.R.
author: Mobarry C.M.
author: Mouchard L.
author: Mural R.J.
author: Myers E.W.
author: Nusskern D.R.
author: Reinert K.
author: Remington K.A.
author: Shatkay H.
author: Shue B.C.
author: Sutton G.G.
author: Turner R.
author: Venter J.C.
author: Walenz B.
author: Waterman M.S.
author: Yooseph S.
author: Zheng X.H.
author: Zhong F.
date: 2005-07
submitted to: EMBL/GenBank/DDBJ
type: Submission Citation

SIPBD8C26D9D54E5891
author: Chen X.
author: Eisenstein S.
author: Farmer A.
author: Halleck A.
author: Hines L.
author: Kalnine N.
author: Kelley T.
author: Koundinya M.
author: LaBaer J.
author: Lin Y.
author: Moreira D.
author: Phelan M.
author: Raphael J.
author: Rolfs A.
date: 2003-05
submitted to: EMBL/GenBank/DDBJ
title: Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
type: Submission Citation

SIPDFE369D8EE3FCC77
date: 2003-01
group: NIEHS SNPs program
submitted to: EMBL/GenBank/DDBJ
type: Submission Citation

CPX-1123
database: ComplexPortal
type: Resource
comment: FOXO3-MYC complex

CPX-514
database: ComplexPortal
type: Resource
comment: c-MYC-BIN1 complex

CPX-91
database: ComplexPortal
type: Resource
comment: Transcriptional activator Myc-Max complex

DB08813
database: DrugBank
type: Resource
comment: Nadroparin

ENOG410IFSM
database: eggNOG
type: Resource
comment: Eukaryota

ENOG41124Q3
database: eggNOG
type: Resource
comment: LUCA

P01106
database: ExpressionAtlas
type: Resource
comment: baseline and differential

P01106
database: Genevisible
type: Resource
comment: HS

http://purl.uniprot.org/hgnc/7553
database: HGNC
type: Resource
comment: MYC

Max
type: Participant

CIP2A
type: Participant

BRD3
type: Participant

EP400
type: Participant

GSK3B
type: Participant

FOXO3
type: Participant

E7
type: Participant

MBD3
type: Participant

SIRT1
type: Participant

CDK4
type: Participant

SP1
type: Participant

HDAC2
type: Participant

TRIP12
type: Participant

CEP57
type: Participant

UBC
type: Participant

PIAS2
type: Participant

RPL11
type: Participant

CCAR2
type: Participant

MCM7
type: Participant

EFTUD2
type: Participant

FBXW7
type: Participant

ZBTB17
type: Participant

CHD4
type: Participant

UBTF
type: Participant

TP53BP1
type: Participant

TRRAP
type: Participant

EP400
type: Participant

SKP2
type: Participant

SIN3B
type: Participant

Sin3b
type: Participant

HDAC3
type: Participant

E7
type: Participant

AXIN1
type: Participant

SIRT6
type: Participant

PIN1
type: Participant

SNIP1
type: Participant

MAX
type: Participant

BIN1
type: Participant

BIN1
type: Participant

CHUK
type: Participant

IKBKG
type: Participant

E7
type: Participant

TOP1
type: Participant

FBXW8
type: Participant

EBNA6
type: Participant

P01106
database: IntAct
type: Resource
comment: 717

IPR002418
database: InterPro
type: Resource
comment: Tscrpt_reg_Myc

IPR003327
database: InterPro
type: Resource
comment: Myc-LZ

IPR011598
database: InterPro
type: Resource
comment: bHLH_dom

IPR012682
database: InterPro
type: Resource
comment: Tscrpt_reg_Myc_N

IPR036638
database: InterPro
type: Resource
comment: HLH_DNA-bd_sf

P01106-1
crc64 checksum: ED5C028029A4C5D1
mass: 48804
modified: 1987-08-13
name: 1
version: 1
type: Simple Sequence
value: MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA

PDB 1A93 tt406tt434
chain: A=406-434

PDB 1EE4 tt320tt328
chain: C/D/E/F=320-328

PDB 1MV0 tt55tt68
chain: A=55-68

PDB 1NKP tt353tt434
chain: A/D=353-434

PDB 2A93 tt406tt434
chain: A=406-434

PDB 2OR9 tt410tt419
chain: P=410-419

PDB 4Y7R tt260tt267
chain: B=260-267

PDB 5I4Z tt350tt439
chain: A/B=350-439

PDB 5I50 tt350tt439
chain: A/B=350-439

PDB 6C4U tt54tt62
chain: G/H/I/J/K/L=54-62

P01106-2
based on: P01106-1
modification: VSP_037813
name: 2
type: Modified Sequence
value: MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA

http://purl.uniprot.org/mim/113970
database: MIM
type: Resource
comment: phenotype

http://purl.uniprot.org/mim/190080
database: MIM
type: Resource
comment: gene

PF00010
database: Pfam
signature sequence match: Pfam PF00010 match 1
type: Resource
comment: HLH

PF01056
database: Pfam
signature sequence match: Pfam PF01056 match 1
type: Resource
comment: Myc_N

PF02344
database: Pfam
signature sequence match: Pfam PF02344 match 1
type: Resource
comment: Myc-LZ

A01349
database: PIR
type: Resource
comment: TVHUM

A01350
database: PIR
type: Resource
comment: TVHUT

PIRSF001705
database: PIRSF
signature sequence match: PIRSF PIRSF001705 match 1
type: Resource
comment: Myc_protein

22570985973626414tt1
position: 1
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt10
position: 10
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt11
position: 11
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt114
position: 114
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt120
position: 120
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt143
position: 143
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt148
position: 148
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt157
position: 157
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt160
position: 160
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt161
position: 161
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt170
position: 170
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt171
position: 171
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt203
position: 203
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt230
position: 230
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt240
position: 240
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt245
position: 245
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt275
position: 275
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt293
position: 293
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt298
position: 298
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt317
position: 317
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt322
position: 322
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt323
position: 323
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt329
position: 329
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt33
position: 33
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt353
position: 353
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt354
position: 354
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt37
position: 37
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt371
position: 371
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt378
position: 378
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt382
position: 382
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt384
position: 384
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt39
position: 39
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt392
position: 392
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt406
position: 406
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt413
position: 413
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt434
position: 434
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt439
position: 439
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt52
position: 52
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt56
position: 56
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt57
position: 57
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt58
position: 58
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt59
position: 59
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt6
position: 6
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt62
position: 62
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt7
position: 7
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt71
position: 71
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt8
position: 8
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt86
position: 86
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt88
position: 88
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt91
position: 91
reference: P01106-1
type: ExactPosition
type: Position

22570985973626414tt92
position: 92
reference: P01106-1
type: ExactPosition
type: Position

22570985973626415tt2
position: 2
reference: P01106-2
type: ExactPosition
type: Position

22570985973626415tt6
position: 6
reference: P01106-2
type: ExactPosition
type: Position

PR00044
database: PRINTS
type: Resource
comment: LEUZIPPRMYC

PS50888
database: PROSITE
signature sequence match: PROSITE PS50888 match 1
type: Resource
comment: BHLH

NP 002458.2
database: RefSeq
type: Resource
comment: NM_002467.4

SM00353
database: SMART
signature sequence match: SMART SM00353 match 1
type: Resource
comment: HLH

SSF47459
database: SUPFAM
signature sequence match: SUPFAM SSF47459 match 1
type: Resource
comment: SSF47459

uc064qdj.1
database: UCSC
type: Resource
comment: human

http://purl.uniprot.org/uniprot/#_12F3AAFDFF5CFE92_rdfs.comment_38E41ED568F836FB
object: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7(PubMed:25775507, PubMed:17558397). Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029). Interacts with CIP2A; leading to the stabilization of MYC (PubMed:17632056).
predicate: comment
subject: SIP25FA819EC35956A5

http://purl.uniprot.org/uniprot/#_1AE53CBD1094DD7F_rdfs.comment_782B4E4A40FE3168
object: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
predicate: comment
subject: SIPC9F9754EBEF21CC6

http://purl.uniprot.org/uniprot/#_1C1C1814D1DC4564_rdfs.comment_F94A8FCC45399633
object: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
predicate: comment
subject: SIP09AF17E10F428EA2

http://purl.uniprot.org/uniprot/#_2E7B9984C84A180F_rdfs.comment_B9619535D120F116
object: Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
predicate: comment
subject: SIP9F0A4E53C1DC66C7

http://purl.uniprot.org/uniprot/#_54772955F73D0045_rdfs.comment_7B6338126B698C72
object: Initiates from CTG codon.
predicate: comment
subject: SIP46AE063A6A8E303D

http://purl.uniprot.org/uniprot/#_59D60D4F5FD5EB72_rdfs.comment_C5E8DC0A1DE4E019
object: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).
predicate: comment
subject: SIP34039CB5D4DEB1E8

http://purl.uniprot.org/uniprot/#_D5408DBF655610B3_rdfs.comment_9062D68AA2759BEB
object: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
predicate: comment
subject: SIPD6EDA7C7B6F50ECF

P01106-citation-14702039
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
object: http://purl.uniprot.org/citations/14702039
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-15103331
scope: INTERACTION WITH FBXW7
scope: MUTAGENESIS OF THR-58 AND SER-62
scope: PHOSPHORYLATION AT THR-58 AND SER-62
scope: UBIQUITINATION
object: http://purl.uniprot.org/citations/15103331
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-15489334
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
object: http://purl.uniprot.org/citations/15489334
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-15674325
scope: INTERACTION WITH PARP10
object: http://purl.uniprot.org/citations/15674325
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-15723054
scope: INTERACTION WITH TAF1C
object: http://purl.uniprot.org/citations/15723054
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-1597196
scope: PHOSPHORYLATION
object: http://purl.uniprot.org/citations/1597196
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-16126174
scope: ACETYLATION AT LYS-143; LYS-157; LYS-275; LYS-317; LYS-323 AND LYS-371
scope: IDENTIFICATION BY MASS SPECTROMETRY
object: http://purl.uniprot.org/citations/16126174
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-16421571
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
object: http://purl.uniprot.org/citations/16421571
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-17081983
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
scope: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58
object: http://purl.uniprot.org/citations/17081983
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-17308053
scope: INTERACTION WITH RIOX1
object: http://purl.uniprot.org/citations/17308053
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-17311883
scope: INTERACTION WITH KDM5A AND KDM5B
object: http://purl.uniprot.org/citations/17311883
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-17558397
scope: DEUBIQUITINATION BY USP28
scope: INTERACTION WITH FBXW7
scope: MUTAGENESIS OF THR-58 AND SER-62
scope: PHOSPHORYLATION AT THR-58 AND SER-62
scope: SUBCELLULAR LOCATION
scope: UBIQUITINATION
object: http://purl.uniprot.org/citations/17558397
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-17632056
scope: INTERACTION WITH CIP2A
object: http://purl.uniprot.org/citations/17632056
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-17873522
scope: DEUBIQUITINATION BY USP28
scope: INTERACTION WITH FBXW7
scope: UBIQUITINATION
object: http://purl.uniprot.org/citations/17873522
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-18035408
scope: BIOTECHNOLOGY
object: http://purl.uniprot.org/citations/18035408
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-18669648
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
scope: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58; SER-62 AND SER-71
object: http://purl.uniprot.org/citations/18669648
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-19413330
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
object: http://purl.uniprot.org/citations/19413330
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-19608861
scope: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
object: http://purl.uniprot.org/citations/19608861
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-19966300
scope: MUTAGENESIS OF THR-58 AND SER-62
scope: PHOSPHORYLATION AT SER-62 BY CDK2
object: http://purl.uniprot.org/citations/19966300
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-20068231
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
scope: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-161
object: http://purl.uniprot.org/citations/20068231
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-20551172
scope: UBIQUITINATION
object: http://purl.uniprot.org/citations/20551172
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-2069907
scope: CHROMOSOMAL TRANSLOCATION WITH BTG1
object: http://purl.uniprot.org/citations/2069907
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-20713526
scope: MUTAGENESIS OF THR-58 AND SER-62
scope: PHOSPHORYLATION AT SER-62 BY CDK2
scope: REVIEW ON SENESCENCE
object: http://purl.uniprot.org/citations/20713526
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-21406692
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
scope: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58 AND SER-62
object: http://purl.uniprot.org/citations/21406692
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-2166998
scope: INVOLVEMENT IN BURKITT LYMPHOMA
object: http://purl.uniprot.org/citations/2166998
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-22307329
scope: MUTAGENESIS OF SER-62
scope: PHOSPHORYLATION AT SER-62
object: http://purl.uniprot.org/citations/22307329
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-23186163
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
scope: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-58; SER-62; SER-71 AND SER-293
object: http://purl.uniprot.org/citations/23186163
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-24940000
scope: FUNCTION
object: http://purl.uniprot.org/citations/24940000
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-25775507
scope: DEUBIQUITINATION BY USP36
scope: INTERACTION WITH FBXW7
scope: SUBCELLULAR LOCATION
scope: UBIQUITINATION
object: http://purl.uniprot.org/citations/25775507
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-25956029
scope: FUNCTION
scope: INTERACTION WITH NPM1
object: http://purl.uniprot.org/citations/25956029
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-28112733
scope: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
scope: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-52; LYS-143; LYS-148 AND LYS-298
object: http://purl.uniprot.org/citations/28112733
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-3540591
scope: NUCLEOTIDE SEQUENCE [MRNA] OF 1-170 (ISOFORM 1)
object: http://purl.uniprot.org/citations/3540591
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6298632
scope: ALTERNATIVE SPLICING (ISOFORM 1)
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
object: http://purl.uniprot.org/citations/6298632
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6304538
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
object: http://purl.uniprot.org/citations/6304538
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6304729
scope: ALTERNATIVE SPLICING (ISOFORM 1)
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
object: http://purl.uniprot.org/citations/6304729
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6321164
scope: ALTERNATIVE SPLICING (ISOFORM 1)
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
object: http://purl.uniprot.org/citations/6321164
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6414718
scope: ALTERNATIVE SPLICING (ISOFORM 1)
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
object: http://purl.uniprot.org/citations/6414718
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6419122
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
scope: VARIANT ASP-39
object: http://purl.uniprot.org/citations/6419122
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6547209
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-252
scope: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
object: http://purl.uniprot.org/citations/6547209
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-6714223
scope: ALTERNATIVE SPLICING (ISOFORM 1)
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
object: http://purl.uniprot.org/citations/6714223
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-7642555
scope: GLYCOSYLATION AT THR-58
object: http://purl.uniprot.org/citations/7642555
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-8220424
scope: INVOLVEMENT IN BURKITT LYMPHOMA
scope: VARIANTS ASP-39; SER-57; ALA-59 AND THR-86
object: http://purl.uniprot.org/citations/8220424
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-8386367
scope: PHOSPHORYLATION AT THR-58 AND SER-62
object: http://purl.uniprot.org/citations/8386367
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-8444346
scope: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
object: http://purl.uniprot.org/citations/8444346
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-9315742
scope: PHOSPHORYLATION AT THR-8
object: http://purl.uniprot.org/citations/9315742
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-9680483
scope: STRUCTURE BY NMR OF 402-434 IN COMPLEX WITH MAX
object: http://purl.uniprot.org/citations/9680483
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-SIP8453E82A0A33265A
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
object: SIP8453E82A0A33265A
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-SIPBD8C26D9D54E5891
scope: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
object: SIPBD8C26D9D54E5891
predicate: citation
subject: P01106
type: Citation Statement

P01106-citation-SIPDFE369D8EE3FCC77
scope: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
scope: VARIANTS SER-11; CYS-160; ILE-170 AND VAL-322
object: SIPDFE369D8EE3FCC77
predicate: citation
subject: P01106
type: Citation Statement

P01106
alternative name: SIP230C75A49C879695
alternative name: SIPBF68FDB87AC6AAB5
alternative name: SIPFCC27870547866F5
annotation: CAR_000033
annotation: PRO_0000127293
annotation: VAR_016327
annotation: VAR_016328
annotation: VAR_016329
annotation: VAR_016330
annotation: VAR_063384
annotation: VAR_063385
annotation: VAR_063386
annotation: VAR_063387
annotation: VSP_037813
annotation: SIP0125CD923CE2CC3C
annotation: SIP040E82133C6FDCF1
annotation: SIP09AF17E10F428EA2
annotation: SIP0CC7C6E943DF7193
annotation: SIP0ED6E54C220BAB91
annotation: SIP25FA819EC35956A5
annotation: SIP2618E9B76E51963C
annotation: SIP2E77DBEBBBE77DAD
annotation: SIP307A8D3D00907220
annotation: SIP34039CB5D4DEB1E8
annotation: SIP3B027CC9F161202B
annotation: SIP3D16CED5F0843C6F
annotation: SIP3D1D679A94EB5479
annotation: SIP46AE063A6A8E303D
annotation: SIP4ACE6097F115E845
annotation: SIP4FA447EF3BE164E2
annotation: SIP4FD5B7D867E978C2
annotation: SIP5531583C3C81CD1E
annotation: SIP5D3DF0A5D52C2D89
annotation: SIP5F5DC4CF579C03A1
annotation: SIP642B013950FFE587
annotation: SIP6DD819A44057CF1C
annotation: SIP746C2941AC55DC6E
annotation: SIP7C7001DAF5CD9E30
annotation: SIP7E7B17D383B70253
annotation: SIP8000AFD82D784FE0
annotation: SIP84D3E8420F257550
annotation: SIP86C7F979D399D8EE
annotation: SIP87D7DDDBC325D86D
annotation: SIP9BDA8FA0A6473C42
annotation: SIP9E576E5011677CF8
annotation: SIP9F0A4E53C1DC66C7
annotation: SIP9FF119DF0FD1B979
annotation: SIPA4CA49D170C79EC7
annotation: SIPB2AF4EB7E01EACED
annotation: SIPC4720839A51B9A67
annotation: SIPC8D21C336A10AE5F
annotation: SIPC8FB091933A6B6AF
annotation: SIPC9F9754EBEF21CC6
annotation: SIPCD653B7CE7A48EC3
annotation: SIPD6EDA7C7B6F50ECF
annotation: SIPD9545061546028A3
annotation: SIPDA78FCDDAD36783C
annotation: SIPDC8182773D5E2E3A
annotation: SIPDD2D12653BDD0E89
annotation: SIPDF9A13BE302270F4
annotation: SIPE00D6BD282621623
annotation: SIPE46A9C28FD6E9B45
annotation: SIPE6D721DBC876F4DE
annotation: SIPF705A52F43DA2FBE
annotation: SIPFA4E4204FEF69104
annotation: SIPFA83519668BD4E79
annotation: SIPFB0DB4D8FD771898
citation: http://purl.uniprot.org/citations/14702039
citation: http://purl.uniprot.org/citations/15103331
citation: http://purl.uniprot.org/citations/15489334
citation: http://purl.uniprot.org/citations/15674325
citation: http://purl.uniprot.org/citations/15723054
citation: http://purl.uniprot.org/citations/1597196
citation: http://purl.uniprot.org/citations/16126174
citation: http://purl.uniprot.org/citations/16421571
citation: http://purl.uniprot.org/citations/17081983
citation: http://purl.uniprot.org/citations/17308053
citation: http://purl.uniprot.org/citations/17311883
citation: http://purl.uniprot.org/citations/17558397
citation: http://purl.uniprot.org/citations/17632056

SIP0125CD923CE2CC3C
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt56tt56
substitution: LL
type: Sequence Conflict Annotation

SIP03D2795767CD173C
full name: Myc proto-oncogene protein
type: Structured Name

SIP040E82133C6FDCF1
range: 22570985973626414tt62tt62
type: Modified Residue Annotation
comment: Phosphoserine; by DYRK2, GSK3 and CDK2

SIP09AF17E10F428EA2
type: Biotechnology Annotation
comment: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.

SIP0CC7C6E943DF7193
conflicting sequence: SIP3C1016FE19ADFB31
range: 22570985973626414tt62tt62
substitution: P
type: Sequence Conflict Annotation

SIP0ED6E54C220BAB91
range: 22570985973626414tt293tt293
type: Modified Residue Annotation
comment: Phosphoserine

SIP1CA63788893EE52F
citation: http://purl.uniprot.org/citations/6419122
type: External Sequence
comment: no nucleotide entry

SIP230C75A49C879695
full name: Class E basic helix-loop-helix protein 39
short name: bHLHe39
type: Structured Name

SIP25FA819EC35956A5
type: Subunit Annotation
comment: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7(PubMed:25775507, PubMed:17558397). Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029). Interacts with CIP2A; leading to the stabilization of MYC (PubMed:17632056).

SIP2618E9B76E51963C
range: 22570985973626414tt62tt62
substitution: A
type: Mutagenesis Annotation
comment: Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Impaired inhibition of Ras-induced senescence. Abolishes phosphorylation by DYRK2, and subsequent phosphorylation by GSK3B at Thr-58.

SIP2E77DBEBBBE77DAD
range: 22570985973626414tt6tt6
type: Modified Residue Annotation
comment: Phosphoserine

SIP307A8D3D00907220
range: 22570985973626414tt58tt58
substitution: A
type: Mutagenesis Annotation
comment: Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Normal inhibition of Ras-induced senescence.

SIP34039CB5D4DEB1E8
type: Function Annotation
comment: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).

SIP3D16CED5F0843C6F
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt245tt245
substitution: S
type: Sequence Conflict Annotation

SIP3D1D679A94EB5479
range: 22570985973626414tt371tt371
type: Modified Residue Annotation
comment: N6-acetyllysine; by PCAF

SIP46AE063A6A8E303D
sequence: P01106-2
type: Caution Annotation
comment: Initiates from CTG codon.

SIP4ACE6097F115E845
range: 22570985973626414tt88tt91
type: Compositional Bias Annotation
comment: Poly-Gly

SIP4FA447EF3BE164E2
range: 22570985973626414tt148tt148
type: Cross-link Annotation
comment: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate

SIP4FD5B7D867E978C2
range: 22570985973626414tt52tt52
type: Cross-link Annotation
comment: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

SIP5531583C3C81CD1E
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt203tt203
substitution: R
type: Sequence Conflict Annotation

SIP5D3DF0A5D52C2D89
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt6tt7
substitution: TI
type: Sequence Conflict Annotation

SIP642B013950FFE587
range: 22570985973626414tt33tt37
type: Compositional Bias Annotation
comment: Poly-Gln

SIP6DD819A44057CF1C
range: 22570985973626414tt58tt58
type: Modified Residue Annotation
comment: Phosphothreonine; by GSK3; alternate

SIP746C2941AC55DC6E
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt230tt230
substitution: A
type: Sequence Conflict Annotation

SIP7C7001DAF5CD9E30
range: 22570985973626414tt161tt161
type: Modified Residue Annotation
comment: Phosphoserine

SIP7E7B17D383B70253
range: 22570985973626414tt71tt71
type: Modified Residue Annotation
comment: Phosphoserine

SIP8000AFD82D784FE0
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt92tt92
substitution: N
type: Sequence Conflict Annotation

SIP84D3E8420F257550
range: 22570985973626414tt354tt406
type: Domain Extent Annotation
comment: bHLH

SIP86C7F979D399D8EE
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt114tt114
substitution: N
type: Sequence Conflict Annotation

SIP87D7DDDBC325D86D
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt171tt171
substitution: S
type: Sequence Conflict Annotation

SIP9BDA8FA0A6473C42
range: 22570985973626414tt143tt143
type: Cross-link Annotation
comment: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate

SIP9E576E5011677CF8
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt240tt240
substitution: F
type: Sequence Conflict Annotation

SIP9F0A4E53C1DC66C7
type: PTM Annotation
comment: Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.

SIPA4CA49D170C79EC7
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt10tt10
substitution: K
type: Sequence Conflict Annotation

SIPBF68FDB87AC6AAB5
full name: Proto-oncogene c-Myc
type: Structured Name

SIPC4720839A51B9A67
range: 22570985973626414tt298tt298
type: Cross-link Annotation
comment: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

SIPC8D21C336A10AE5F
range: 22570985973626414tt143tt143
type: Modified Residue Annotation
comment: N6-acetyllysine; by PCAF; alternate

SIPC8FB091933A6B6AF
range: 22570985973626414tt413tt434
type: Region Annotation
comment: Leucine-zipper

SIPC9F9754EBEF21CC6
type: PTM Annotation
comment: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).

SIPCD653B7CE7A48EC3
range: 22570985973626414tt329tt329
type: Modified Residue Annotation
comment: Phosphoserine; by PIM2; in vitro

SIPD6EDA7C7B6F50ECF
type: Disease Annotation
comment: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.

SIPD9545061546028A3
range: 22570985973626414tt8tt8
type: Modified Residue Annotation
comment: Phosphothreonine; by RAF; in vitro

SIPDA78FCDDAD36783C
range: 22570985973626414tt317tt317
type: Modified Residue Annotation
comment: N6-acetyllysine; by PCAF

SIPDC8182773D5E2E3A
range: 22570985973626414tt323tt323
type: Modified Residue Annotation
comment: N6-acetyllysine; by PCAF

SIPDD2D12653BDD0E89
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt120tt120
substitution: G
type: Sequence Conflict Annotation

SIPDF9A13BE302270F4
range: 22570985973626414tt275tt275
type: Modified Residue Annotation
comment: N6-acetyllysine; by PCAF

SIPE00D6BD282621623
range: 22570985973626414tt157tt157
type: Modified Residue Annotation
comment: N6-acetyllysine; by PCAF

SIPE46A9C28FD6E9B45
disease: http://purl.uniprot.org/diseases/2613
type: Disease Annotation
comment: The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.

SIPF705A52F43DA2FBE
conflicting sequence: SIP1CA63788893EE52F
range: 22570985973626414tt88tt88
substitution: D
type: Sequence Conflict Annotation

SIPFA4E4204FEF69104
conflicting sequence: SIP4EFC52F28AA8137E
range: 22570985973626415tt2tt2
sequence: P01106-2
substitution: N
type: Sequence Conflict Annotation

SIPFA83519668BD4E79
conflicting sequence: SIP4EFC52F28AA8137E
range: 22570985973626415tt6tt6
sequence: P01106-2
substitution: E
type: Sequence Conflict Annotation

SIPFB0DB4D8FD771898
range: 22570985973626414tt148tt148
type: Modified Residue Annotation
comment: N6-acetyllysine; alternate

SIPFCC27870547866F5
full name: Transcription factor p64
type: Structured Name

http://purl.uniprot.org/uniprot/P01106#attribution-0033B290626EF42C0ADB89E9BE6EA6B6
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/21533051

http://purl.uniprot.org/uniprot/P01106#attribution-052922A05FE85726519ABE1627204ED7
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/2166998

http://purl.uniprot.org/uniprot/P01106#attribution-080ED3982FEC43F7C43A0689717F3D20
evidence: ECO_0000305
manual: true

http://purl.uniprot.org/uniprot/P01106#attribution-0EB5BB17E7E3B5C9784511A9243A1CC1
creator: Reactome
evidence: ECO_0000304
manual: true

http://purl.uniprot.org/uniprot/P01106#attribution-15F6E2D94A2B38C24545A11AFB749D82
creator: UniProtKB
evidence: ECO_0000303
manual: true
source: http://purl.uniprot.org/citations/9924025

http://purl.uniprot.org/uniprot/P01106#attribution-16F8D0254FDC2F85C0A616FF3C026DBD
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/19966300

http://purl.uniprot.org/uniprot/P01106#attribution-20AD3C0019D717A31EBEB5C4E5B590B3
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/19179467

http://purl.uniprot.org/uniprot/P01106#attribution-2DDCDD294C156AC935C0CC0CFDFD6D51
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/17308053

http://purl.uniprot.org/uniprot/P01106#attribution-3670F52E9B2385CCCA10865CF8E8D150
creator: NTNU SB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/10723141

http://purl.uniprot.org/uniprot/P01106#attribution-39C7E5AB8FB658DB7C1AAB725DDB483A
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/25956029

http://purl.uniprot.org/uniprot/P01106#attribution-3BD1901CDC18DB4A95D7E2E6C201153B
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/17558397

http://purl.uniprot.org/uniprot/P01106#attribution-4560708EB4595A3792D6936AF972A7B4
creator: CAFA
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/15459207

http://purl.uniprot.org/uniprot/P01106#attribution-458B85CCAE76EFD02256CE6A6E301321
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/9315742

http://purl.uniprot.org/uniprot/P01106#attribution-46C5BA04531CDA247CF4F190F068FA3A
creator: UniProtKB
evidence: ECO_0000270
manual: true
source: http://purl.uniprot.org/citations/18291362

http://purl.uniprot.org/uniprot/P01106#attribution-4E692197A279AB7724FF882AD4AFEB1E
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/15103331

http://purl.uniprot.org/uniprot/P01106#attribution-50901D527D8BD0526A21D9240D9821B2
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/9680483

http://purl.uniprot.org/uniprot/P01106#attribution-519A1D4EC2F715207C858D86CB5ECE59
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/8220424

http://purl.uniprot.org/uniprot/P01106#attribution-52504966ED4570A91358EACB6611E310
creator: CAFA
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/19160485

http://purl.uniprot.org/uniprot/P01106#attribution-52C629FA2E2E7310A9DE64C660FBEFE5
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/17081983

http://purl.uniprot.org/uniprot/P01106#attribution-562790AF8B5C480E76C1DEF7448FAA3E
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/17558397

http://purl.uniprot.org/uniprot/P01106#attribution-5752D7CB649C5657C079D516E3EEA54C
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/17873522

http://purl.uniprot.org/uniprot/P01106#attribution-5A9078FF72A6B0DF921BE0F7A2BDA8BB
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/15723054

http://purl.uniprot.org/uniprot/P01106#attribution-5EC5628B6620B9B8DFD61226E04695C2
creator: UniProtKB
evidence: ECO_0000304
manual: true
source: http://purl.uniprot.org/citations/18987311

http://purl.uniprot.org/uniprot/P01106#attribution-609619A7DF3E53CE5E48EDEF8B8F9DD1
evidence: ECO_0000250
manual: true

http://purl.uniprot.org/uniprot/P01106#attribution-6103C20478A35958B4D92E64332D433F
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/24940000

http://purl.uniprot.org/uniprot/P01106#attribution-68097C5C9D39FEEE8BE013645ACBBDD4
creator: UniProtKB
evidence: ECO_0000250
manual: true

http://purl.uniprot.org/uniprot/P01106#attribution-681391A6B35D7FD694F911F5390B784C
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/18035408

http://purl.uniprot.org/uniprot/P01106#attribution-6E7D4A760DD81E249878BB052C9E876A
evidence: ECO_0000250
manual: true
source: P01108

http://purl.uniprot.org/uniprot/P01106#attribution-72F1E0B492B3D3B9AFF13C3C44BEBA3D
evidence: ECO_0000255
manual: true
source: PRU00981

http://purl.uniprot.org/uniprot/P01106#attribution-74333102C8BEB28C2006A4EB50DE0C26
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/28112733

http://purl.uniprot.org/uniprot/P01106#attribution-775F3F1CA215A619B5B0B879E4C4FF23
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/8386367

http://purl.uniprot.org/uniprot/P01106#attribution-787FC9489313B870BBB84641D3228566
creator: BHF-UCL
evidence: ECO_0000315
manual: true
source: http://purl.uniprot.org/citations/19786833

http://purl.uniprot.org/uniprot/P01106#attribution-7D79C0700707DAF32EC8D5BA09D2A5C6
creator: CAFA
evidence: ECO_0000353
manual: true
source: http://purl.uniprot.org/citations/19160485

http://purl.uniprot.org/uniprot/P01106#attribution-7DB32E6C84D778AFA477FD7D1F44C9D5
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/11793365

http://purl.uniprot.org/uniprot/P01106#attribution-7FC2DA925D11B7A9D9F799DC8266E512
creator: MGI
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/21447833

http://purl.uniprot.org/uniprot/P01106#attribution-861FEBCEB2C0FAE7B877B83D6EAF75A6
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/18669648

http://purl.uniprot.org/uniprot/P01106#attribution-869EC34B8C5532DBC8E8E582A34DAE3A
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/10962037

http://purl.uniprot.org/uniprot/P01106#attribution-88AB0E5DF89134E60E86861DB0A3B33B
creator: BHF-UCL
evidence: ECO_0000315
manual: true
source: http://purl.uniprot.org/citations/17765874

http://purl.uniprot.org/uniprot/P01106#attribution-92B699DFF41C2786F4A9F66F785FA7BF
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/22307329

http://purl.uniprot.org/uniprot/P01106#attribution-9363999E98C4CB25B8E2711F0AE2A43D
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/17311883

http://purl.uniprot.org/uniprot/P01106#attribution-A08A621B6CE75358AB9F1999A2B228C9
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/2069907

http://purl.uniprot.org/uniprot/P01106#attribution-A2471182ADF8BF483A8E5620BDADAFA4
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/6419122

http://purl.uniprot.org/uniprot/P01106#attribution-A380F9342EEA3CD68D94AD823EA91D72
creator: UniProtKB
evidence: ECO_0000315
manual: true
source: http://purl.uniprot.org/citations/9924025

http://purl.uniprot.org/uniprot/P01106#attribution-A387BE5A2B45BB47268DA3748251D671
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/17873522

http://purl.uniprot.org/uniprot/P01106#attribution-A8922E2CCC924269D7AF38D4C1EFF408
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/9924025

http://purl.uniprot.org/uniprot/P01106#attribution-AD293D4CCE4FB0689EA6E2F77E655D67
creator: UniProtKB
evidence: ECO_0000315
manual: true
source: http://purl.uniprot.org/citations/17873522

http://purl.uniprot.org/uniprot/P01106#attribution-B3B0145002CF2D2171B9A0D70AA7EB44
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/20713526

http://purl.uniprot.org/uniprot/P01106#attribution-B800389FA77B4D7914359F647F92242F
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/16126174

http://purl.uniprot.org/uniprot/P01106#attribution-B93AC144D92E1D8BB3053AAB4CCF01DE
creator: UniProtKB
evidence: ECO_0000304
manual: true
source: http://purl.uniprot.org/citations/10962037

http://purl.uniprot.org/uniprot/P01106#attribution-BA06964C6C9C1DA726ABD15C35E4857C
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/17632056

http://purl.uniprot.org/uniprot/P01106#attribution-C0D24CA15CD75EB873FC734536682A68
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/18818310

http://purl.uniprot.org/uniprot/P01106#attribution-C72023BA5F06BE8637826362845535DF
evidence: ECO_0000244
manual: true
source: 1NKP

http://purl.uniprot.org/uniprot/P01106#attribution-C8810D92850D4AD671B3E5E8DD22AE65
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/7642555

http://purl.uniprot.org/uniprot/P01106#attribution-CC4B5AB75D8F15DD7864AC597115C92B
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/18987311

http://purl.uniprot.org/uniprot/P01106#attribution-CF1227FC8A3F6D5E1E65451F2FDD52C3
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/25775507

http://purl.uniprot.org/uniprot/P01106#attribution-D21EF334EC6B0A4A5B6E41F18A1D45F7
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/21406692

http://purl.uniprot.org/uniprot/P01106#attribution-E18CC9AA15A4C1491C463F92B1EF960B
creator: BHF-UCL
evidence: ECO_0000315
manual: true
source: http://purl.uniprot.org/citations/12837246

http://purl.uniprot.org/uniprot/P01106#attribution-F01046A97CAED480A3811F00C86696E1
evidence: ECO_0000303
manual: true
source: http://purl.uniprot.org/citations/15489334

http://purl.uniprot.org/uniprot/P01106#attribution-F0540E4DCAA42EA47264FAF1C2945FC9
evidence: ECO_0000269
manual: true
source: SIPDFE369D8EE3FCC77

http://purl.uniprot.org/uniprot/P01106#attribution-F2C85D8ECA0C2BF5A9841037D51618B7
creator: BHF-UCL
evidence: ECO_0000250
manual: true

http://purl.uniprot.org/uniprot/P01106#attribution-F6677FDDBDD029FE235C5CF4EFE36AD2
creator: UniProtKB
evidence: ECO_0000314
manual: true
source: http://purl.uniprot.org/citations/25775507

http://purl.uniprot.org/uniprot/P01106#attribution-F6A995B3F9A34BE1F2CACD2516393C60
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/23186163

http://purl.uniprot.org/uniprot/P01106#attribution-F7F7628BD135B0C3EAFD83D533AB0584
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/19608861

http://purl.uniprot.org/uniprot/P01106#attribution-F8046E461348999CD21BBA98CB194346
creator: UniProtKB
evidence: ECO_0000315
manual: true
source: http://purl.uniprot.org/citations/25956029

http://purl.uniprot.org/uniprot/P01106#attribution-FB6997DAA0FDC011541422619B304A4C
creator: UniProtKB
evidence: ECO_0000353
manual: true
source: http://purl.uniprot.org/citations/15674325

http://purl.uniprot.org/uniprot/P01106#attribution-FC38E214291DF78B0221913C77F1B59D
creator: UniProtKB
evidence: ECO_0000270
manual: true
source: http://purl.uniprot.org/citations/17873522

http://purl.uniprot.org/uniprot/P01106#attribution-FC95B70DE07F93731B0F9B133F50F5FA
evidence: ECO_0000269
manual: true
source: http://purl.uniprot.org/citations/15674325

http://purl.uniprot.org/uniprot/P01106#attribution-FED5A5F74F365A4D7A58BB2730874EAB
evidence: ECO_0000244
manual: true
source: http://purl.uniprot.org/citations/20068231

Erythroleukemia
type: Tissue

Uterus
type: Tissue

Testis
type: Tissue

Promyelocytic leukemia
type: Tissue

Placenta
type: Tissue

Cervix
type: Tissue

Cervix carcinoma
type: Tissue

MYC
type: Gene
alternative label: BHLHE39

interaction-447544-1184963
experiments: 4
participant: Max
participant: EBI-447544
xeno: true
type: Interaction
type: Non Self Interaction

interaction-447544-1379376
experiments: 2
participant: CIP2A
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-1383460
experiments: 3
participant: BRD3
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-15698003
experiments: 2
participant: EP400
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-15870655
experiments: 3
participant: GSK3B
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-1644164
experiments: 3
participant: FOXO3
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-1776887
experiments: 5
participant: E7
participant: EBI-447544
xeno: true
type: Interaction
type: Non Self Interaction

interaction-447544-1783068
experiments: 3
participant: MBD3
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-1802965
experiments: 4
participant: SIRT1
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-295644
experiments: 2
participant: CDK4
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-298336
experiments: 4
participant: SP1
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-301821
experiments: 2
participant: HDAC2
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-308443
experiments: 7
participant: TRIP12
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-308614
experiments: 3
participant: CEP57
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-3390054
experiments: 5
participant: UBC
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-348555
experiments: 4
participant: PIAS2
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-354380
experiments: 3
participant: RPL11
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-355410
experiments: 8
participant: CCAR2
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-355924
experiments: 6
participant: MCM7
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-357897
experiments: 5
participant: EFTUD2
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-359574
experiments: 4
participant: FBXW7
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-372156
experiments: 9
participant: ZBTB17
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-372916
experiments: 2
participant: CHD4
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-396235
experiments: 2
participant: UBTF
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-396540
experiments: 2
participant: TP53BP1
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-399128
experiments: 4
participant: TRRAP
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-399163
experiments: 4
participant: EP400
participant: EBI-447544
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-456291
experiments: 2
participant: EBI-447544
participant: SKP2
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-540462
experiments: 7
participant: EBI-447544
participant: SIN3B
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-591450
experiments: 8
participant: EBI-447544
participant: Sin3b
xeno: true
type: Interaction
type: Non Self Interaction

interaction-447544-607682
experiments: 6
participant: EBI-447544
participant: HDAC3
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-617698
experiments: 2
participant: EBI-447544
participant: EBI-617698
xeno: true
type: Interaction
type: Non Self Interaction

interaction-447544-7005254
experiments: 2
participant: EBI-447544
participant: E7
xeno: true
type: Interaction
type: Non Self Interaction

interaction-447544-710484
experiments: 10
participant: EBI-447544
participant: AXIN1
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-712415
experiments: 3
participant: EBI-447544
participant: SIRT6
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-714158
experiments: 5
participant: EBI-447544
participant: PIN1
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-749336
experiments: 9
participant: EBI-447544
participant: SNIP1
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-751711
experiments: 33
participant: EBI-447544
participant: MAX
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-7689134
experiments: 3
participant: EBI-447544
participant: BIN1
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-7689211
experiments: 2
participant: EBI-447544
participant: BIN1
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-81249
experiments: 3
participant: EBI-447544
participant: CHUK
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-81279
experiments: 3
participant: EBI-447544
participant: IKBKG
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-866453
experiments: 2
participant: EBI-447544
participant: E7
xeno: true
type: Interaction
type: Non Self Interaction

interaction-447544-876302
experiments: 2
participant: EBI-447544
participant: TOP1
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-914770
experiments: 3
participant: EBI-447544
participant: FBXW8
xeno: false
type: Interaction
type: Non Self Interaction

interaction-447544-9255985
experiments: 11
participant: EBI-447544
participant: EBNA6
xeno: true
type: Interaction
type: Non Self Interaction

1EE4
chain sequence mapping: PDB 1EE4 tt320tt328
database: PDB
method: X-Ray Crystallography
resolution: 2.10
type: Structure Resource

1NKP
chain sequence mapping: PDB 1NKP tt353tt434
database: PDB
method: X-Ray Crystallography
resolution: 1.80
type: Structure Resource

2OR9
chain sequence mapping: PDB 2OR9 tt410tt419
database: PDB
method: X-Ray Crystallography
resolution: 2.70
type: Structure Resource

4Y7R
chain sequence mapping: PDB 4Y7R tt260tt267
database: PDB
method: X-Ray Crystallography
resolution: 1.90
type: Structure Resource

5I4Z
chain sequence mapping: PDB 5I4Z tt350tt439
database: PDB
method: X-Ray Crystallography
resolution: 1.95
type: Structure Resource

5I50
chain sequence mapping: PDB 5I50 tt350tt439
database: PDB
method: X-Ray Crystallography
resolution: 2.70
type: Structure Resource

6C4U
chain sequence mapping: PDB 6C4U tt54tt62
database: PDB
method: X-Ray Crystallography
resolution: 2.60
type: Structure Resource

Orphanet_480541
database: Orphanet
type: Resource
comment: High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement

Orphanet 543
database: Orphanet
type: Resource
comment: Burkitt lymphoma

Orphanet_99861
database: Orphanet
type: Resource
comment: Precursor T-cell acute lymphoblastic leukemia

Myc
type: Resource
comment: Wikipedia; Myc entry