Systolic blood pressure x educational attainment (some college) interaction (2df)
27,617 European ancestry individuals with some college education, 20,253 European ancestry individuals without college education, 8,128 African ancestry individuals with some college education, 8,537 African ancestry individuals without college education, 1,138 Asian ancestry individuals with some college education, 10,214 Asian ancestry individuals without college education, 1,869 Hispanic/Latin American individuals with some college education, 3,276 Hispanic/Latin American individuals without college education
131,584 European ancestry individuals with some college education, 110,940 European ancestry individuals without college education, 1,494 African ancestry individuals with some college education, 5,704 African ancestry individuals without college education, 2,339 Asian ancestry individuals with some college education, 8,567 Asian ancestry individuals without college education, 4,133 Hispanic individuals with some college education, 7,498 Hispanic individuals without college education
Affymetrix, Illumina [~ 18800000] (imputed)
Systolic blood pressure x educational attainment (graduated college) interaction (2df)
27,367 European ancestry college graduated individuals, 51,673 European ancestry non-college graduated individuals, 3,605 African ancestry college graduated individuals, 13,060 African ancestry non-college graduated individuals, 291 Asian ancestry college graduated individuals, 457 Asian ancestry non-college graduated individuals, 786 Hispanic/Latin American college graduated individuals, 4,359 Hispanic/Latin American non-college graduated individuals
67,506 European ancestry college graduated individuals, 189,531 European ancestry non-college graduated individuals, 781 African ancestry college graduated individuals, 6,417 African ancestry non-college graduated individuals, 651 Asian ancestry college graduated individuals, 5,296 Asian ancestry non-college graduated individuals, 1,703 Hispanic college graduated individuals, 9,928 Hispanic non-college graduated individuals
Diastolic blood pressure x educational attainment (some college) interaction (2df)
Diastolic blood pressure x educational attainment (graduated college) interaction (2df)
Mean arterial pressure x educational attainment (some college) interaction (2df)
Mean arterial pressure x educational attainment (graduated college) interaction (2df)
Pulse pressure x educational attainment (some college) interaction (2df)
Pulse pressure x educational attainment (graduated college) interaction (2df)
Venous thromboembolism
104 European ancestry cases, 211 European ancestry controls
Alzheimer's disease or posttraumatic stress syndrome (pleiotropy)
21,982 LOAD cases, 41,994 controls, 2,424 European ancestry PTSD cases, 7,113 European ancestry controls, 1,968 African American LOAD cases, 2,479 African American PTSD cases, 10,672 African American controls
1011 PTSD cases, 1045 controls
Intelligence
269,867 European ancestry individuals
Affymetrix, Illumina [9295118] (imputed)
CV-A6-associated hand, foot, and mouth disease (severe vs mild)
115 Han Chinese ancestry severe cases, 115 Han Chinese ancestry mild controls
Protein quantitative trait loci
376 European ancestry individuals
400 European ancestry individuals
394 European ancestry individuals
548 European ancestry individuals
up to 376 European ancestry individuals
up to 400 European ancestry individuals
up to 394 European ancestry individuals
up to 548 European ancestry individuals
Anthracycline-induced cardiotoxicity in early breast cancer
42 Korean ancestry cases, 215 Korean ancestry controls
Heel bone mineral density
426,824 British ancestry individuals
Fractures
53,184 British ancestry cases, 373,611 British ancestry controls
367,900 European ancestry cases, 363,919 European ancestry controls
Nonalcoholic fatty liver disease
2,448 African American individuals, 1,365 European ancestry individuals, 753 Hispanic individuals, 141 other ancestries individuals
Nontraumatic osteonecrosis of the femoral head
118 European ancestry cases, 56,811 European ancestry controls
Attention deficit hyperactivity disorder
17,149 European ancestry cases, 32,411 European ancestry controls
Attention deficit hyperactivity disorder (persistent)
6,532 European ancestry cases, 15,874 European ancestry controls
Attention deficit hyperactivity disorder (childhood)
10,617 European ancestry cases, 16,537 European ancestry controls
LDL cholesterol levels
12,685 Chinese ancestry individuals
HDL cholesterol levels
Total cholesterol levels
Total triglycerides levels
Weight gain in amisulpride-treated first-episode psychosis
184 European ancestry individuals, 9 African ancestry individuals, 6 Hispanic/Latin American individuals, 3 South Asian ancestry individuals, 2 East Asian ancestry individuals, 2 individuals
Central corneal thickness
32,292 European ancestry individuals, 9,623 East Asian ancestry individuals, 1,367 Hispanic/Latino individuals, 757 African American individuals
Urine 6-bromotryptophan levels in chronic kidney disease
4,863 European ancestry individuals
Multiple myeloma
2,434 European ancestry cases, 2,705 European ancestry controls
Affymetrix, Illumina [5864648] (imputed)
Monoclonal gammopathy of undetermined significance
754 European ancestry cases, 879 European ancestry controls
Brain amyloid deposition (PET imaging)
4,120 Europea ancestry individuals, 89 African American individuals, 105 Hispanic individuals
Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis)
349 East Asian ancestry cases, 1,118 East Asian ancestry treated controls
Insomnia
651,923 European ancestry males, 679,087 European ancestry females
Morningness
434,835 European ancestry individuals
Affymetrix, Illumina [11597492] (imputed)
Sleep duration
384,317 European ancestry individuals
Affymetrix, Illumina [10862567] (imputed)
Ease of getting up in the morning
385,949 European ancestry individuals
Affymetrix, Illumina [10862568] (imputed)
Daytime nap
386,577 European ancestry individuals
Affymetrix, Illumina [10858887] (imputed)
Daytime sleepiness
386,548 European ancestry individuals
Affymetrix, Illumina [10820725] (imputed)
Snoring
359,916 European ancestry individuals
Postoperative myocardial infarction after cardiac surgery
87 cases, 939 controls
Postoperative stroke after cardiac surgery
17 cases, 1,089 controls
Postoperative acute renal failure after cardiac surgery
52 cases, 1,020 controls
Postoperative atrial fibrillation after cardiac surgery
242 cases, 640 controls
Postoperative delirium after cardiac surgery
148 cases, 819 controls
Postoperative complication after cardiac surgery
Up to 1,163 individuals
Glycated hemoglobin levels in type 1 diabetes
4,622 Finnish ancestry individuals
up to 3,097 individuals
Depressive symptoms x herpes simplex 1 infection interaction
2,839 British ancestry individuals
Depression x herpes simplex 1 infection interaction
1,464 British ancestry cases, 1,487 British ancestry controls
Sweet taste preference
12,312 Japanese ancestry individuals
Chronic hepatitis B infection
1,810 East Asian cases, 9,002 East Asian seropositive controls
648 East Asian cases, 3,190 East Asian seropositive controls
Autism spectrum disorders (restricted interests)
2,509 individuals
Autism spectrum disorders (social interaction)
Autism spectrum disorders (joint attention)
Autism spectrum disorders (peer interaction)
Autism spectrum disorders (nonverbal communication)
Autism spectrum disorders (repetitive sensory-motor behaviour)
Receptive language ability
400 European ancestry children
Parent of origin effect on receptive language ability (paternal)
Parent of origin effect on receptive language ability (maternal)
Rate of cognitive decline in Alzheimer's disease
3,946 European ancestry cases
Matrix metalloproteinase levels
982 Scottish ancestry individuals
Matrix metalloproteinase-10 levels
Neurotrophin-3 levels
Osteoprotegerin levels
Oncostatin-M levels
PD-L1 levels
Stem cell factor levels
Sirtuin-2 levels
SLAMF1 levels
Sulfotrasferase 1A1 levels
STAM binding protein levels
Transforming growth factor-alpha levels
Tumor necrosis factor beta levels
Tumor necrosis factor receptor superfamily member 9 levels
Tumor necrosis factor ligand superfamily member 14 levels
Tumor necrosis factor ligand superfamily member 10 levels
Tumor necrosis factor ligand superfamily member 11 levels
Tumor necrosis factor ligand superfamily member 12 levels
Urokinase-type plasminogen activator levels
Vascular endothelial growth factor A levels
Migraine and/or diastolic blood pressure
757,601 European ancestry individuals with blood pressure measurements, 59,674 European ancestry migraine cases, 316,078 European ancestry controls
Migraine and/or systolic blood pressure
Migraine and/or pulse pressure
Migraine with aura and/or diastolic blood pressure
757,601 European ancestry individuals with blood pressure measurements, up to 59,674 European ancestry migraine cases, 316,078 European ancestry controls
Migraine with aura and/or systolic blood pressure
Migraine with aura and/or pulse pressure
Migraine without aura and/or diastolic blood pressure
Migraine without aura and/or systolic blood pressure
Migraine without aura and/or pulse pressure
Peginterferon alfa-2a treatment response in chronic hepatitis B infection
up to 1,108 East Asian cases, up to 465 European ancestry cases, up to 63 cases
Gut microbiota (bacterial taxa, hurdle binary method)
2,223 European ancestry individuals
1,667 European ancestry individuals
Gut microbiota (bacterial taxa, rank normal transformation method)
Preeclampsia (fetal genotype effect)
2,145 Central Asian ancestry cases, 2,027 Central Asian ancestry controls
452 Kazakh ancestry cases, 361 Kazakh ancestry controls
4,630 European ancestry cases, 373,345 European ancestry controls
580 European ancestry cases, 760 European ancestry controls
Preeclampsia (maternal genotype effect)
2,296 Central Asian ancestry cases, 2,059 Central Asian ancestry controls, 7,219 European ancestry cases, 155,660 European ancestry controls
592 Kazakh ancestry cases, 361 Kazakh ancestry controls, 2,043 European ancestry cases, 6,018 European ancestry controls
2,296 Central Asian ancestry cases, 2,059 Central Asian ancestry controls
592 Kazakh ancestry cases, 361 Kazakh ancestry controls
7,219 European ancestry cases, 155,660 European ancestry controls
2,043 European ancestry cases, 6,018 European ancestry controls
2,145 Central Asian ancestry cases, 2,027 Central Asian ancestry controls, 4,630 European ancestry cases, 373,345 European ancestry controls
452 Kazakh ancestry cases, 361 Kazakh ancestry controls, 580 European ancestry cases, 760 European ancestry controls
Amyotrophic lateral sclerosis
22,040 cases, 62,644 controls
837 European ancestry cases, 665 European ancestry controls
Recurrence of Clostridium difficile infection x bezlotuxumab treatment interaction (2df test)
704 European, African American and Asian ancestry individuals
Crohn's disease
713 Japanese ancestry cases, 2,063 Japanese ancestry controls
Autoimmune thyroid disease
30,234 European ancestry cases, 724,172 European ancestry controls
Affymetrix, Illumina [42900000] (imputed)
Genome-wide genotyping array, Genome-wide sequencing
Lung function (FVC)
321,047 European ancestry individuals
79,005 European ancestry individuals
FEV1
Lung function (FEV1/FVC)
Peak expiratory flow
24,218 European ancestry individuals
Rheumatic heart disease
510 Northern Indian cases, 344 Northern Indian controls, 162 Fijian Indian cases, 147 Fijian Indian controls
150 European ancestry cases, 1,309 European ancestry controls
L-selectin levels
620 European ancestry individuals, 600 Chinese ancestry individuals, 579 African American individuals, 604 Hispanic individuals
Targeted genotyping array [Cardio-MetaboChip, Exome Array]
Epithelial ovarian cancer
755 African American cases, 1,235 African American controls
Lactate dehydrogenase levels
98,585 Icelandic ancestry individuals
Creatine kinase levels
63,159 Icelandic ancestry individuals
Creatine kinase levels in statin users
5,207 Icelandic ancestry individuals
Creatine kinase levels in off-statin users
6,877 Icelandic ancestry individuals
Lactate dehydrogenase levels in statin users
6,266 Icelandic ancestry individuals
Lactate dehydrogenase levels in off-statin users
Emotional recognition
4,780 European ancestry children
2,382 European ancestry boys
2,393 European ancestry girls
Response to antiepileptic mood-stabilizing treatment in bipolar disorder
199 European ancestry cases
Thrombin-induced platelet aggregation
1,184 European ancestry individuals
4E-BP1 levels
Adenosine Deaminase levels
Axin-1 levels
beta-nerve growth factor levels
Caspase 8 levels
CCL11 levels
CCL19 levels
CCL20 levels
CCL23 levels
CCL25 levels
CCL28 levels
CCL3 levels
CCL4 levels
CD244 levels
CD40 levels
CD5 levels
CD6 levels
CDCP1 levels
Colony stimulating factor levels
Cystatin D levels
CX3CL1 levels
CXCL1 levels
CXCL10 levels
CXCL11 levels
CXCL5 levels
CXCL6 levels
CXCL9 levels
DNER levels
EN-RAGE levels
Fibroblast growth factor 19 levels
Fibroblast growth factor 21 levels
Fibroblast growth factor 23 levels
Fibroblast growth factor 5 levels
Flt3L levels
Hepatocyte growth factor levels
Interleukin-10 receptor B levels
Interleukin-12 subunit B levels
interleukin 15 receptor subunit alpha levels
interleukin-18 receptor 1 levels
Interleukin-10 levels
Interleukin-18 levels
Interleukin-6 levels
Interleukin-7 levels
Interleukin-8 levels
Transforming growth factor-beta levels
Leukemia inhibitory factor receptor levels
Monocyte chemoattractant protein-1 levels
Monocyte chemoattractant protein-2 levels
Monocyte chemoattractant protein-3 levels
Monocyte chemoattractant protein-4 levels
Acute anterior uveitis in ankylosing spondylitis
2,752 European ancestry cases, 3,836 European ancestry controls
Hip bone mineral content accrual during adolescent growth spurt
125 women, 133 men
Peak hip bone mineral content
190 women, 174 men
Body mass index
1,142 Indo-European Indian ancestry individuals
6,117 Indo-European Indian ancestry individuals
Essential hypertension (time to event)
76,566 British ancestry cases, 206,305 British ancestry controls
Abdominal hernia (time to event)
45,957 British ancestry cases, 236,914 British ancestry controls
Hyperlipidemia (time to event)
35,623 British ancestry cases, 247,248 British ancestry controls
Osteoarthrosis (time to event)
29,071 British ancestry cases, 253,800 British ancestry controls
Cardiac dysrhythmias (time to event)
25,585 British ancestry cases, 257,286 British ancestry controls
Asthma (time to event)
25,240 British ancestry cases, 257,631 British ancestry controls
Cataract (time to event)
22,635 British ancestry cases, 260,236 British ancestry controls
Coronary atherosclerosis (time to event)
19,079 British ancestry cases, 263,792 British ancestry controls
Type 2 diabetes (time to event)
18,557 British ancestry cases, 264,314 British ancestry controls
Parkinson's disease (time to event)
1,345 British ancestry cases, 281,526 British ancestry controls
Alzheimer's disease (time to event)
641 British ancestry cases, 282,230 British ancestry controls
Schizophrenia (time to event)
551 British ancestry cases, 282,320 British ancestry controls
Major depressive disorder
29,475 European ancestry cases, 63,482 European ancestry controls
Major depressive disorder in trauma exposed individuals
13,393 European ancestry cases, 10,701 European ancestry controls
Major depressive disorder in trauma-unexposed individuals
9,487 European ancestry cases, 39,677 European ancestry controls
Trauma exposure
35,269 European ancestry cases, 63,451 European ancestry controls
Trauma exposure in major depressive disorder
13,393 European ancestry cases, 9,487 European ancestry controls
Trauma exposure in major depressive disorder-negative individuals
10,701 European ancestry cases, 39,677 European ancestry controls
Asthma
84,492 European ancestry cases, 2,149 African American cases, 606 Hispanic cases, 1,239 Japanese ancestry cases, 437,036 European ancestry controls, 6,055 African American controls, 792 Hispanic controls, 3,976 Japanese ancestry controls
64,538 European ancestry cases, 239,321 European ancestry controls
Alzheimer's disease in depression
12 European ancestry cases, 111 European ancestry controls
Cognitive function in depression
222 European ancestry older individuals
Cognitive impairment in depression
31 European ancestry cases, 111 European ancestry controls
Cognitive decline in depression
Breast cancer
3,663 African American cases, 4,687 African American controls
35,373 British ancestry cases, 270,572 British ancestry controls
305,945 British ancestry individuals
Fasting plasma glucose
382 Chinese ancestry twin pairs
Antibody-deficiency-associated primary immunodeficiency
733 European, African, Asian and other ancestry cases, 9,225 European, African, Asian and other ancestry controls
Diastolic blood pressure
1,947 African ancestry individuals
Systolic blood pressure
Diabetic neuropathy in type 2 diabetes
218 European ancestry cases, 382 European ancestry controls
Type 2 diabetes nephropathy
517 European ancestry cases, 84 European ancestry controls
Macrovascular complications in type 2 diabetes
333 European ancestry cases, 226 European ancestry controls
Ophthalmic complications in type 2 diabetes
203 European ancestry cases, 398 European ancestry controls
Cardiovascular death or myocardial infarction in response to clopidogrel treatment
102 European ancestry cases, 2,068 European ancestry controls
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment
72 European ancestry cases, 1,375 European ancestry controls
Stent thrombosis in response to clopidogrel treatment
37 European ancestry cases, 2,542 European ancestry controls
Platelet reactivity in response to clopidogrel treatment
2,592 European ancestry individuals
Parkinson's disease progression (motor)
2,848 individuals
Parkinson's disease progression (cognitive)
2,788 individuals
Parkinson's disease progression (composite)
2,755 individuals
Stroke
3,734 African ancestry cases, 18,317 African ancestry controls
Affymetrix, Illumina [~ 16900000] (imputed)
Endometriosis or migraine
17,054 European and Japanese ancestry endometriosis cases, 29,208 European ancestry migraine cases, 191,858 European and Japanese ancestry controls, 172,931 European ancestry controls
Left ventricular end-diastolic volume
35,407 European ancestry individuals, 95 African ancestry individuals, 108 East Asian ancestry individuals, 303 South Asian ancestry individuals, 128 individuals
940 European ancestry individuals, 299 East Asian ancestry individuals, 507 African American individuals, 438 Hispanic individuals
Left ventricular end-systolic volume
Left ventricular stroke volume
Body surface area-indexed left ventricular end-diastolic volume
Body surface area-indexed left ventricular end-systolic volume
Body surface area-indexed left ventricular stroke volume
Left ventricular ejection fraction
Cleft lip with or without cleft palate
1,692 European ancestry cases, 4,259 European ancestry controls
Obese vs. thin
1,456 British ancestry obese children, 1,471 European ancestry thin adults
up to 7,526 British ancestry obese individuals, 7,962 obese individuals, up to 3,532 British ancestry thin individuals, 8,106 thin individuals
Obesity (extreme)
1,456 British ancestry obese children, 6,460 European ancestry control adults
up to 7,526 British ancestry obese individuals, at least 4,405 obese individuals, up to 20,720 British ancestry controls, 61,166 controls
Normal body mass index vs. thin
1,471 European ancestry thin adults, 6,460 European ancestry control adults
3,532 British ancestry thin individuals, up to 20,720 British ancestry controls
Chronotype (sMEQ score)
7,436 Finnish ancestry individuals
Evening vs. morning chronotype (sMEQ score)
2,364 Finnish ancestry evening individuals, 5,072 Finnish ancestry morning individuals
Evening vs. morning chronotype (self-assessed)
3,759 Finnish ancestry evening individuals , 4,674 Finnish ancestry morning individuals
Attention deficit hyperactivity disorder (inattention symptoms)
71 Korean ancestry ADHD child cases, 64 Korean ancestry child controls
Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms)
27 Korean ancestry child sibling pairs
71 Korean ancestry child cases, 64 Korean ancestry child controls
Lung cancer (survival time) in never smokers
1,569 European ancestry individuals
887 Japanese ancestry individuals
Lung adenocarcinoma (survival time) in never smokers
1,065 European ancestry individuals
871 Japanese ancestry individuals
Drug-induced liver injury (flucloxacillin)
197 European ancestry cases, 6,835 European ancestry controls
Drug-induced liver injury (isoxazolyl penicillins)
6 European ancestry cases, 10,588 European ancestry controls
Drug-induced liver injury (amoxicillin)
15 European ancestry cases, 10,588 European ancestry controls
Drug-induced liver injury
1,806 European ancestry cases, 133 African American cases, 109 Hispanic ancestry cases, 10,397 European ancestry controls, 1,314 African American controls, 718 Hispanic ancestry controls
113 Icelandic ancestry cases, 239,304 Icelandic ancestry controls
Affymetrix, Illumina [3622749] (imputed)
Chronic rhinosinusitis
251 European ancestry whole-genome sequenced cases, 5,357 European ancestry cases, 13,957 European ancestry whole-genome sequenced controls, 746,129 European ancestry controls
Affymetrix, Illumina [up to 37123566] (imputed)
Nasal polyps
86 European ancestry whole-genome sequenced cases, 4,280 European ancestry cases, 13,941 European ancestry whole-genome sequenced controls, 700,740 European ancestry controls
Benign childhood epilepsy with centro-temporal spikes
1,738 Han Chinese ancestry cases, 6,592 Han Chinese ancestry controls
Cardiorespiratory fitness (800m run time)
762 Han Chinese ancestry individuals
Affymetrix, Illumina [5129327] (imputed)
Pancreatic cancer
2,039 Japanese ancestry cases, 32,592 Japanese ancestry controls
1,926 East Asian cases, 8,896 East Asian controls
World class endurance athleticism
662 European ancestry cases, 134 European ancestry controls
Targeted genotyping array [Drug-core array]
Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels
4,365 Ugandan ancestry individuals
2,162 European ancestry individuals
Anti-Epstein-Barr virus viral capsid antigen (VCA) IgG levels
Anti-Kaposi's sarcoma associated herpesvirus ORF73 IgG levels
Anti-Kaposi's sarcoma associated herpesvirus K10.5 IgG levels
Anti-Kaposi's sarcoma associated herpesvirus K8.1 IgG levels
Rheumatoid arthritis
4,068 Korean ancestry cases, 36,487 Korean ancestry controls
Corneal hysteresis
106,041 European ancestry individuals
9,029 European ancestry individuals
Corneal resistance factor
106,030 European ancestry individuals
Coffee consumption
6,080 Korean ancestry cases, 1,788 Korean ancestry controls
Glaucoma (primary open-angle)
309 Korean ancestry cases, 5,400 Korean ancestry controls
875 East Asian ancestry cases, 6,716 East Asian ancestry controls
Coronary artery disease
15,302 Japanese ancestry cases, 36,140 Japanese ancestry controls
15,302 Japanese ancestry cases, 76,014 European and East Asian ancestry cases, 36,140 Japanese ancestry controls, 264,785 European and East Asian ancestry controls
8,216 Japanese ancestry cases, 201,592 Japanese ancestry controls
Atopic dermatitis
2,385 Japanese ancestry cases, 209,651 Japanese ancestry controls
Drug eruption
430 Japanese ancestry cases, 209,651 Japanese ancestry controls
Pollinosis
5,746 Japanese ancestry cases, 206,707 Japanese ancestry controls
Graves' disease
2,176 Japanese ancestry cases, 210,277 Japanese ancestry controls
4,199 Japanese ancestry cases, 208,254 Japanese ancestry controls
Cerebral aneurysm
2,820 Japanese ancestry cases, 192,383 Japanese ancestry controls
Congestive heart failure
9,413 Japanese ancestry cases, 203,040 Japanese ancestry controls
29,319 Japanese ancestry cases, 183,134 Japanese ancestry controls
2,855 Japanese ancestry cases, 15,211 Japanese ancestry controls
Ischemic stroke
17,671 Japanese ancestry cases, 192,383 Japanese ancestry controls
Peripheral artery disease
3,593 Japanese ancestry cases, 208,860 Japanese ancestry controls
1,394 Japanese ancestry cases, 211,059 Japanese ancestry controls
Chronic hepatitis C infection
5,794 Japanese ancestry cases, 206,659 Japanese ancestry controls
Pulmonary tuberculosis
549 Japanese ancestry cases, 211,904 Japanese ancestry controls
Type 2 diabetes
40,250 Japanese ancestry cases, 170,615 Japanese ancestry controls
Biliary tract cancer
339 Japanese ancestry cases, 195,745 Japanese ancestry controls
5,552 Japanese ancestry cases, 89,731 Japanese ancestry controls
Cervical cancer
605 Japanese ancestry cases, 89,731 Japanese ancestry controls
Colorectal cancer
7,062 Japanese ancestry cases, 195,745 Japanese ancestry controls
Endometrial cancer
999 Japanese ancestry cases, 89,731 Japanese ancestry controls
Esophageal cancer
1,300 Japanese ancestry cases, 195,745 Japanese ancestry controls
Gastric cancer
6,563 Japanese ancestry cases, 195,745 Japanese ancestry controls
Hematological malignancy
1,236 Japanese ancestry cases, 211,217 Japanese ancestry controls
Hepatocellular carcinoma
1,866 Japanese ancestry cases, 195,745 Japanese ancestry controls
Lung cancer
4,050 Japanese ancestry cases, 208,403 Japanese ancestry controls
2,440 Japanese ancestry cases, 467 Japanese ancestry controls
Myocardial infarction
14,825 European ancestry cases, 44,000 European and unknown ancestry cases, 2,680 cases, 380,970 European ancestry controls, 123,504 European and unknown ancestry controls, 73,242 controls
14,825 European ancestry cases, 2,680 cases, 380,970 European ancestry controls, 73,242 controls
Gut microbiota alpha diversity (Chao1 index)
541 Japanese ancestry women
1,068 Japanese ancestry individuals
Gut microbiota alpha diversity (PD_whole_tree index)
Gut microbiota alpha diversity (Shannon index)
Gut microbiota beta diversity (weighted UniFrac distance)
Chronic widespread pain
6,815 British ancestry cases, 10,000 British ancestry controls
Multisite chronic pain
387,649 British ancestry individuals
Serum oxytocin levels
951 Sorbian ancestry individuals
Allergic disease (asthma, hay fever and/or eczema) (age of onset)
117,130 European ancestry individuals
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis)
477,968 European ancestry individuals
Response to esketamine in treatment resistant depression
255 European ancestry individuals
Response to esketamine (responder status) in treatment resistant depression
Response to esketamine (remission) in treatment resistant depression
255 European ancestry remitters, 272 European ancestry non-remitters
Hypertension
8,178 Korean ancestry cases, 9,558 Korean ancestry controls
Trigger finger
942 European ancestry cases, 24,472 European ancestry controls
Household income
96,900 British ancestry individuals
Social deprivation
112,005 British ancestry individuals
Carboplatin drug response (IC50)
168 European ancestry individuals
Ara-C drug response (AUC)
432 East Asian, European and African ancestry individuals
Capecitabine drug response (AUC)
424 East Asian, European and African ancestry individuals
430 East Asian, European and African ancestry individuals
Cisplatin drug response (IC50)
431 East Asian, European and African ancestry individuals
Daunorubicin drug response (IC50)
259 European and African ancestry individuals
Etoposide drug response (IC50)
255 European and African ancestry individuals
Paclitaxel drug response (AUC)
164 European and African ancestry individuals
Pemetrexed drug response (AUC)
260 European and African ancestry individuals
90 East Asian ancestry individuals
84 East Asian ancestry individuals
165 European ancestry individuals
166 European ancestry individuals
86 European ancestry individuals
84 European ancestry individuals
77 European ancestry individuals
177 African ancestry individuals
175 African ancestry individuals
172 African ancestry individuals
173 African ancestry individuals
Length of menstrual cycle
44,871 European ancestry women
171 African ancestry individuals
87 African ancestry individuals
176 African ancestry individuals
First fracture in long-term childhood cancer survivors (time to event)
1,164 European ancestry males
771 European ancestry males
1,289 European ancestry females
646 European ancestry females
1,289 European ancestry females, 1,164 European ancestry males
646 European ancestry females, 771 European ancestry males
Carbamazepine-induced liver injury
12 European ancestry cases, 8,438 European ancestry controls
Carbamazepine-induced reaction with eosinophilia and systemic symptoms
25 European ancestry cases, 10,701 European ancestry controls
Carbamazepine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN)
16 European ancestry cases, 8,438 European ancestry controls
Carbamazepine-induced serious cutaneous adverse reaction
43 European ancestry cases, 10,701 European ancestry controls
Viral basal core promoter double mutation in hepatitis B virus surface antigen (HBsAg) seropositivity
218 Chinese ancestry asymptomatic cases, 191 Chinese ancestry asymptomatic controls
203 Chinese ancestry asymptomatic cases, 181 Chinese ancestry asymptomatic controls
Opioid overdose severity score
2,032 European ancestry individuals, 1,445 African American individuals
Visual contour integration
1,931 East Asian ancestry individuals
688 East Asian ancestry individuals
Lean nonalcoholic fatty liver disease
275 Japanese ancestry cases, 1,411 Japanese ancestry controls
Ceramide levels (C24:0)
2,217 European ancestry individuals
Ceramide levels (C22:0)
Interstitial lung diseases in rheumatoid arthritis
358 Japanese ancestry cases, 4,550 Japanese ancestry controls
Anorectal malformation
568 European ancestry cases, 1,860 European ancestry controls
Periodontal disease
1,415 Japanese ancestry male cases, 107,932 Japanese ancestry male controls
Urolithiasis
4,996 Japanese ancestry male cases, 104,351 Japanese ancestry male controls
4,284 Japanese ancestry female cases, 98,503 Japanese ancestry female controls
1,123 Japanese ancestry female cases, 101,789 Japanese ancestry female controls
200 Japanese ancestry female cases, 101,789 Japanese ancestry female controls
3,286 Japanese ancestry female cases, 99,820 Japanese ancestry female controls
1,579 Japanese ancestry female cases, 101,527 Japanese ancestry female controls
3,325 Japanese ancestry female cases, 99,781 Japanese ancestry female controls
1,818 Japanese ancestry female cases, 94,928 Japanese ancestry female controls
3,509 Japanese ancestry female cases, 99,597 Japanese ancestry female controls
7,708 Japanese ancestry female cases, 95,398 Japanese ancestry female controls
6,590 Japanese ancestry female cases, 94,928 Japanese ancestry female controls
809 Japanese ancestry female cases, 102,297 Japanese ancestry female controls
516 Japanese ancestry female cases, 102,590 Japanese ancestry female controls
2,635 Japanese ancestry female cases, 100,471 Japanese ancestry female controls
162 Japanese ancestry female cases, 102,944 Japanese ancestry female controls
14,545 Japanese ancestry female cases, 87,841 Japanese ancestry female controls
128 Japanese ancestry female cases, 98,090 Japanese ancestry female controls
2,566 Japanese ancestry female cases, 98,090 Japanese ancestry female controls
168 Japanese ancestry female cases, 98,090 Japanese ancestry female controls
1,678 Japanese ancestry female cases, 98,090 Japanese ancestry female controls
535 Japanese ancestry female cases, 102,571 Japanese ancestry female controls
482 Japanese ancestry female cases, 98,090 Japanese ancestry female controls
1,340 Japanese ancestry female cases, 101,766 Japanese ancestry female controls
154 Japanese ancestry female cases, 98,090 Japanese ancestry female controls
21,611 Japanese ancestry male cases, 87,736 Japanese ancestry male controls
11,081 Japanese ancestry male cases, 97,455 Japanese ancestry male controls
2,784 Japanese ancestry male cases, 106,563 Japanese ancestry male controls
878 Japanese ancestry male cases, 108,469 Japanese ancestry male controls
3,159 Japanese ancestry male cases, 106,188 Japanese ancestry male controls
387 Japanese ancestry male cases, 108,960 Japanese ancestry male controls
25,705 Japanese ancestry male cases, 82,774 Japanese ancestry male controls
211 Japanese ancestry male cases, 97,655 Japanese ancestry male controls
4,496 Japanese ancestry male cases, 97,655 Japanese ancestry male controls
1,132 Japanese ancestry male cases, 97,655 Japanese ancestry male controls
4,885 Japanese ancestry male cases, 97,655 Japanese ancestry male controls
701 Japanese ancestry male cases, 108,646 Japanese ancestry male controls
1,384 Japanese ancestry male cases, 97,655 Japanese ancestry male controls
2,710 Japanese ancestry male cases, 106,637 Japanese ancestry male controls
288 Japanese ancestry male cases, 97,655 Japanese ancestry male controls
Arrhythmia
11,525 Japanese ancestry male cases, 97,822 Japanese ancestry male controls
Cataracts
11,641 Japanese ancestry male cases, 97,706 Japanese ancestry male controls
Chronic obstructive pulmonary disease
2,855 Japanese ancestry male cases, 103,089 Japanese ancestry male controls
Cirrhosis
1,347 Japanese ancestry male cases, 108,000 Japanese ancestry male controls
Epilepsy
1,266 Japanese ancestry male cases, 108,081 Japanese ancestry male controls
Glaucoma
2,770 Japanese ancestry male cases, 106,577 Japanese ancestry male controls
Interstitial lung disease
495 Japanese ancestry male cases, 108,852 Japanese ancestry male controls
Keloid
323 Japanese ancestry male cases, 109,024 Japanese ancestry male controls
Nephrotic syndrome
583 Japanese ancestry male cases, 108,764 Japanese ancestry male controls
Osteoporosis
696 Japanese ancestry male cases, 108,651 Japanese ancestry male controls
6,336 Japanese ancestry female cases, 96,770 Japanese ancestry female controls
12,981 Japanese ancestry female cases, 90,125 Japanese ancestry female controls
460 Japanese ancestry female cases, 98,503 Japanese ancestry female controls
837 Japanese ancestry female cases, 102,269 Japanese ancestry female controls
877 Japanese ancestry female cases, 102,229 Japanese ancestry female controls
2,991 Japanese ancestry female cases, 100,115 Japanese ancestry female controls
311 Japanese ancestry female cases, 102,795 Japanese ancestry female controls
489 Japanese ancestry female cases, 102,617 Japanese ancestry female controls
374 Japanese ancestry female cases, 102,732 Japanese ancestry female controls
7,092 Japanese ancestry female cases, 96,014 Japanese ancestry female controls
1,804 Japanese ancestry female cases, 101,302 Japanese ancestry female controls
1,642 Japanese ancestry female cases, 101,464 Japanese ancestry female controls
Herpes simplex virus 7 U14 antibody levels
8,528 White British ancestry individuals
Anti-helicobacter pylori IgG seropositivity
8,735 White British ancestry individuals
Helicobacter pylori CagA antibody levels
985 White British ancestry individuals
Helicobacter pylori Catalase antibody levels
1,558 White British ancestry individuals
Helicobacter pylori GroEL antibody levels
2,716 White British ancestry individuals
Helicobacter pylori OMP antibody levels
2,640 White British ancestry individuals
Helicobacter pylori UREA antibody levels
2,251 White British ancestry individuals
Helicobacter pylori VacA antibody levels
1,571 White British ancestry individuals
Anti-herpes simplex virus 1 IgG seropositivity
Herpes simplex virus 1 mgG-1 antibody levels
6,199 White British ancestry individuals
Anti-herpes simplex virus 2 IgG seropositivity
Herpes simplex virus 2 mgG-1 antibody levels
1,382 White British ancestry individuals
Anti-polyomavirus 2 IgG seropositivity
Polyomavirus 2 JC VP1 antibody levels
5,118 White British ancestry individuals
Anti-Merkel cell polyomavirus IgG seropositivity
Merkel cell polyomavirus VP1 antibody levels
5,915 White British ancestry individuals
Anti-Toxoplasma gondii IgG seropositivity
Toxoplasma gondii p22 antibody levels
1,308 White British ancestry individuals
Toxoplasma gondii sag1 antibody levels
3,919 White British ancestry individuals
Anti-varicella zoster virus IgG seropositivity
Varicella zoster virus glycoproteins E and I antibody levels
7,595 White British ancestry individuals
Iron status biomarkers (ferritin levels)
246,139 European ancestry individuals
Affymetrix, Illumina [40000000] (imputed)
Iron status biomarkers (total iron binding capacity)
135,430 European ancestry individuals
Iron status biomarkers (iron levels)
163,511 European ancestry individuals
Iron status biomarkers (transferrin saturation)
131,471 European ancestry individuals
Factor VII activity or levels
24,075 European ancestry individuals, 3,420 African American individuals
Affymetrix, Illumina [10044948] (imputed)
Factor VII activity
20,014 European ancestry individuals, 3,420 African American individuals
6,264 Japanese ancestry individuals
5,975 Japanese ancestry individuals
77,418 East Asian cases, 356,122 East Asian controls
Affymetrix, Illumina [11800000] (imputed)
Cardiovascular disease in systemic lupus erythematosus
133 European ancestry cases, 681 Europen ancestry controls
84 European ancestry cases, 959 European ancestry controls
Severe COVID-19 infection with respiratory failure (analysis I)
1,610 European ancestry cases, 2,205 European ancestry controls
Severe COVID-19 infection with respiratory failure (analysis II)
1,610 European ancestry cases, 2,180 European ancestry controls
Systemic mastocytosis
93 European ancestry cases, 5,606 European ancestry controls
Cutaneous mastocytosis
141 European ancestry cases, 5,606 European ancestry controls
Cutaneous mastocytosis (adult)
65 European ancestry cases, 5,606 European ancestry controls
Mastocytosis
234 European ancestry cases, 5,606 European ancestry controls
Cutaneous mastocytosis (childhood)
78 European ancestry cases, 5,606 European ancestry controls
Arterial stiffness (carotid-femoral pulse wave velocity)
6,430 European ancestry individuals
Arterial stiffness (brachial-femoral pulse wave velocity)
3,643 European ancestry individuals
Arterial stiffness (brachial-ankle pulse wave velocity)
6,734 European ancestry individuals
Combined resilience (covariance of educational attainment with residual cognitive resilience)
5,108 European ancestry individuals (unimpaired cognition, mild cognitive impairment or Alzheimer’s disease)
Affymetrix, Illumina [4840740] (imputed)
Residual cognitive resilience
3,820 European ancestry cognitively unimpaired individuals
Chronic back pain
35,705 European ancestry male cases, 166,372 European ancestry male controls
10,723 European ancestry male cases, 33,017 European ancestry male controls
7,758 European ancestry male cases, 36,074 European ancestry male controls
28,009 European ancestry male cases, 130,236 European ancestry male controls
43,230 European ancestry female cases, 194,524 European ancestry female controls
15,139 European ancestry female cases, 34,926 European ancestry female controls
8,987 European ancestry female cases, 35,502 European ancestry female controls
34,207 European ancestry female cases, 159,058 European ancestry female controls
1,625 Chinese ancestry cases, 2,100 Chinese ancestry controls
5,353 Chinese ancestry cases, 6,685 Chinese ancestry controls, 254 European ancestry cases, 2,835 European ancestry controls
Motor fluctuations in levodopa treated Parkinson's disease
219 Korean ancestry cases, 522 Korean ancestry controls
Levodopa-induced dyskinesia in levodopa treated Parkinson's disease
172 Korean ancestry cases, 569 Korean ancestry controls
Bipolar disorder
1,822 Han Chinese ancestry cases, 4,650 Han Chinese ancestry controls
958 Han Chinese ancestry cases, 2,050 Han Chinese ancestry controls
1,822 Han Chinese ancestry cases, 4,650 Han Chinese ancestry controls, 20,352 European ancestry cases, 31,358 European ancestry controls
Anti-BK polyomavirus IgG seropositivity
BK polyomavirus VP1 antibody levels
8,555 White British ancestry individuals
Anti-chlamydia trachomatis IgG seropositivity
Chlamydia trachomatis momp A antibody levels
964 White British ancestry individuals
Chlamydia trachomatis momp D antibody levels
1,371 White British ancestry individuals
Chlamydia trachomatis pGP3 antibody levels
1,784 White British ancestry individuals
Chlamydia trachomatis PorB antibody levels
273 White British ancestry individuals
Chlamydia trachomatis tarp-D F1 antibody levels
1,635 White British ancestry individuals
Chlamydia trachomatis tarp-D F2 antibody levels
2,074 White British ancestry individuals
Anti-cytomegalovirus IgG seropositivity
Cytomegalovirus pp28 antibody levels
5,087 White British ancestry individuals
Cytomegalovirus pp52 antibody levels
5,681 White British ancestry individuals
Cytomegalovirus pp150 antibody levels
5,136 White British ancestry individuals
Anti-Epstein-Barr virus IgG seropositivity
Epstein-Barr virus EA-D antibody levels
7,763 White British ancestry individuals
Epstein-Barr virus EBNA-1 antibody levels
7,972 White British ancestry individuals
Epstein-Barr virus VCA p18 antibody levels
8,518 White British ancestry individuals
Epstein-Barr virus ZEBRA antibody levels
8,191 White British ancestry individuals
Anti-herpes simplex virus 6 IgG seropositivity
Anti-herpes simplex virus 6 IE1A IgG seropositivity
Herpes simplex virus 6 IE1B antibody levels
6,968 White British ancestry individuals
Anti-herpes simplex virus 6 IE1B IgG seropositivity
7,119 White British ancestry individuals
Herpes simplex virus 6 p101k antibody levels
1,951 White British ancestry individuals
Anti-herpes simplex virus 7 IgG seropositivity
High myopia
1,632 Japanese ancestry cases, 1,586 Japanese ancestry controls
800 East Asian ancestry cases, 81 Singaporean ancestry cases, 5,169 East Asian ancestry controls, 4,777 Singaporean ancestry controls
Affymetrix, Illumina [4996193] (imputed)
Celiac disease
12,567 European ancestry cases, 381 Hispanic cases, 14,013 European ancestry controls, 813 Hispanic controls
Low density lipoprotein cholesterol levels
431,167 European ancestry individuals
Metabolic syndrome
1,596 Indo-European ancestry cases, 562 Indo-European ancestry controls
5,021 Indo-European ancestry cases, 2,914 Indo-European ancestry controls
Corneal curvature
29,580 European ancestry individuals, 14,462 Asian ancestry individuals
88,218 European ancestry individuals
Affymetrix, Illumina [8936601] (imputed)
29,580 European ancestry individuals
14,462 Asian ancestry individuals
Affymetrix, Illumina [7861976] (imputed)
8,620 individuals (<25 years old)
35,422 individuals (>=25 years old)
Autistic traits score (Social and Communication Disorders Checklist)
5,628 European ancestry children
Oral cavity cancer
631 European ancestry cases, 4,493 European ancestry controls
2,568 European ancestry cases, 3,232 European ancestry controls
Oropharynx cancer
1,144 European ancestry cases, 4,493 European ancestry controls
2,328 European ancestry cases, 3,232 European ancestry controls
Hypopharyngeal or laryngeal cancer
394 European ancestry cases, 4,493 European ancestry controls
295 European ancestry cases, 3,232 European ancestry controls
Head and neck squamous cell carcinoma
2,171 European ancestry cases, 4,493 European ancestry controls
5,205 European ancestry cases, 3,232 European ancestry controls
Ovarian cancer
720 Japanese ancestry cases, 89,731 Japanese ancestry controls
442 Japanese ancestry cases, 195,745 Japanese ancestry controls
Prostate cancer
5,408 Japanese ancestry cases, 103,939 Japanese ancestry controls
17,861 Japanese ancestry cases, 194,592 Japanese ancestry controls
24,622 Japanese ancestry cases, 187,831 Japanese ancestry controls
3,315 Japanese ancestry cases, 201,592 Japanese ancestry controls
2,184 Japanese ancestry cases, 210,269 Japanese ancestry controls
Endometriosis
734 Japanese ancestry cases, 102,372 Japanese ancestry controls
2,143 Japanese ancestry cases, 210,310 Japanese ancestry controls
5,761 Japanese ancestry cases, 206,692 Japanese ancestry controls
806 Japanese ancestry cases, 211,647 Japanese ancestry controls
812 Japanese ancestry cases, 211,641 Japanese ancestry controls
957 Japanese ancestry cases, 211,496 Japanese ancestry controls
7,788 Japanese ancestry cases, 204,665 Japanese ancestry controls
3,219 Japanese ancestry cases, 209,234 Japanese ancestry controls
6,638 Japanese ancestry cases, 205,815 Japanese ancestry controls
Uterine fibroids
5,954 Japanese ancestry cases, 95,010 Japanese ancestry controls
3,932 Japanese ancestry male cases, 103,089 Japanese ancestry male controls
1,262 Japanese ancestry male cases, 107,862 Japanese ancestry male controls
230 Japanese ancestry male cases, 107,862 Japanese ancestry male controls
2,460 Japanese ancestry male cases, 106,887 Japanese ancestry male controls
597 Japanese ancestry male cases, 108,750 Japanese ancestry male controls
874 Japanese ancestry male cases, 108,473 Japanese ancestry male controls
1,002 Japanese ancestry male cases, 97,455 Japanese ancestry male controls
5,904 Japanese ancestry male cases, 103,443 Japanese ancestry male controls
Glycated hemoglobin levels
1,721 Malay ancestry individuals
2,704 Malay ancestry individuals
Genome-wide genotyping array, Exome-wide sequencing
Opioid use disorder
10,544 European ancestry cases, 72,163 European ancestry controls, 5,212 African American cases, 26,876 African American controls
748 European ancestry cases, 361,107 European ancestry controls
Adult diffuse glioma (IDH mutation)
622 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
390 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse glioma (IDH wildtype)
698 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
409 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse glioma (IDH mutation, 1p/19q codeletion)
245 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
145 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted)
316 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
245 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse triple positive glioma (IDH and TERT mutations, 1p19q codeletion)
189 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
138 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse glioma (IDH and TERT mutations)
39 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
13 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse glioma (IDH mutation only)
241 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
214 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse glioma (TERT mutation only)
419 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
159 European and unknown ancestry cases, 808 European and unknown ancestry controls
Adult diffuse triple negative glioma (IDH and TERT wildtype, 1p/19q non-codeleted)
87 European and unknown ancestry cases, 1,889 European and unknown ancestry controls
33 European and unknown ancestry cases, 808 European and unknown ancestry controls
Self-rated health
111,749 British ancestry individuals
Sudden cardiac arrest in coronary artery disease
948 European ancestry cases, 3,050 European ancestry controls
Fractures (paediatric)
48 European ancestry cases, 3,182 European ancestry controls
Simvastatin-induced myopathy
85 European ancestry cases, 2,501 controls
Atorvastatin-induced myopathy
28 European ancestry cases, 2,501 controls
Statin-induced myopathy (severe)
32 European ancestry cases, 2,501 controls
Statin-induced myopathy
128 European ancestry cases, 2,501 controls
Mitochondrial DNA copy number (white blood cells)
1,333 males
Mitochondrial DNA copy number
3,647 European ancestry children
2,102 European ancestry neonates
5,461 European ancestry mothers
3,405 European ancestry mothers
1,338 females
3,405 European ancestry females, 1,338 females
5,461 European ancestry females, 1,338 females
37 African American cases, 177 Japanese American cases, 140 Latino cases, 85 Native Hawaiian cases, 67 European ancestry cases, 218 African American controls, 221 Japanese American controls, 182 Latino controls, 158 Native Hawaiian controls, 244 European ancestry controls
Percent liver fat
269 African American individuals, 424 Japanese American individuals, 345 Latino individuals, 270 Native Hawaiian individuals, 382 European ancestry individuals
1,550 African American individuals, 762 Chinese ancestry individuals, 2,477 European ancestry individuals, 1,412 Hispanic individuals
Targeted genotyping array [Exome array, Cardio-Metabochip]
Height
598 Peruvian individuals
3,134 Peruvian individuals
133,384 European ancestry cases, 113,789 European ancestry controls
Invasive breast cancer
106,278 European ancestry cases, 91,477 European ancestry controls
Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)
8,602 European ancestry triple negative cases, 9,414 European ancestry BRCA1 mutation carrier cases, 100,971 European ancestry controls
Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer
1,324 European ancestry individuals
Major depressive disorder (lifetime)
16,301 British ancestry cases, 50,870 British ancestry controls
Major depressive disorder (lifetime with recurrence)
10,302 British ancestry cases, 49,083 British ancestry controls
Help-seeking from a GP
113,262 British ancestry cases, 219,360 British ancestry controls
Help-seeking from a psychiatrist
36,286 British ancestry cases, 297,126 British ancestry controls
Major depressive disorder symptoms (low mood or anhedonia)
21,177 British ancestry cases, 58,398 British ancestry controls
Help-seeking from a GP (without major depressive disorder symptoms)
8,632 British ancestry cases, 49,493 British ancestry controls
Depression or depression symptoms
19,805 British ancestry cases, 234,114 British ancestry controls
Depression
9,176 British ancestry cases, 203,235 British ancestry controls
Neuroticism
274,107 British ancestry individuals
Smoking status (ever vs never smokers)
336,066 British ancestry individuals
Adverse response to chemoterapy (fluoropyrimidines)
504 European ancestry cases
Physical aggression in schizophrenia
205 individuals
Verbal aggression in schizophrenia
Aggression against property in schizophrenia
Tafenoquine efficacy in P. vivax malaria (recurrence by 6 months)
438 cases
Tafenoquine efficacy in P. vivax malaria (recurrence by 4 months)
Tafenoquine efficacy in P. vivax malaria (time to recurrence up to 6 months)
Myeloid clonal hematopoiesis
1,166 cases, 30,892 controls
Cerebrospinal fluid t-tau:AB1-42 ratio
3,146 European ancestry individuals
First year height change in growth hormone-treated short stature
504 European ancestry individuals, 88 individuals
113 Brazilian individuals
HAGH protein levels in plasma
281 individuals
CDH6 protein levels in plasma
Tumor necrosis factor levels
30,912 European ancestry individuals
Vaginal microbiome composition (L. iners)
171 Kenyan ancestry individuals
Vaginal microbiome composition (G. vaginalis)
Vaginal microbiome composition (Shannon diversity index)
Vaginal microbiome composition (community state type)
Vaginal microbiome composition (L. crispatus)
42 Kenyan ancestry cases, 129 Kenyan ancestry controls
Alcohol use disorder
57,564 European ancestry cases, 256,395 European ancestry controls
Problematic alcohol use (MTAG)
972,915 European ancestry individuals
Alcohol consumption (drinks per week) (MTAG)
Problematic alcohol use
435,563 European ancestry individuals
25,892 Japanese ancestry cases, 142,336 Japanese ancestry controls
25,892 Japanese ancestry cases, 95,342 European ancestry cases, 142,336 Japanese ancestry controls, 385,488 European ancestry controls
604 Jewish cases, 2,332 Jewish controls
Affymetrix, Illumina [1286673] (imputed)
Allergic march (atopic dermatitis to allergic rhinitis)
225 African American child cases, 963 African American child controls
148 African American child cases, 1,151 African American child controls
Allergic march (atopic dermatitis to asthma)
335 African American child cases, 963 African American child controls
220 African American child cases, 1,151 African American child controls
115 African American child male cases, 466 African American child male controls
74 African American child male cases, 543 African American child male controls
198 African American child male cases, 466 African American child male controls
127 African American child male cases, 543 African American child male controls
110 African American child female cases, 496 African American child female controls
74 African American child female cases, 606 African American child female controls
137 African American child female cases, 496 African American child female controls
92 African American child female cases, 606 African American child female controls
Suicide attempts
3,470 European ancestry cases, 150,090 European ancestry controls
8,296 European ancestry individuals
Deliberate self-harm
6,711 European ancestry cases, 146,849 European ancestry controls
2-hydroxyisobutyrate levels
996 European ancestry individuals
3-aminoisobutyrate levels
3-hydroxybutyrate + 3-aminoisobutyrate levels
3-hydroxyisobutyrate levels
3-hydroxyisovalerate levels
3-Indoxylsulfate levels
4-deoxyerythronic acid levels
4-deoxythreonic acid levels
5-oxoproline levels
Acetate levels
Acetone levels
Alanine levels
Carnitine levels
Citrate levels
Creatine levels
Creatinine levels
Dimethylamine levels
Formate levels
Glucose levels
Glutamine levels
Glycine levels
Hippurate levels
Isoleucine levels
Lactate levels
Leucine levels
Caffeine consumption from coffee
373,522 European ancestry individuals
Caffeine consumption from tea
395,866 European ancestry individuals
Caffeine consumption from coffee or tea
362,316 European ancestry individuals
Lysine levels
N-acetyl neuraminic acid levels
N-methyl-2-pyridone-5-carboxamide levels
N-methylnicotinic acid levels
N-methylpicolinic acid levels
N1-methyl-nicotinamide levels
P-cresol sulfate levels
P-hydroxyphenylacetate levels
Pantothenic acid levels
Proline betaine levels
Scyllo-inositol levels
Succinate levels
Sucrose levels
Taurine levels
Trimethylamine levels
Trimethylamine oxide levels
Tyrosine levels
Urea levels
Valine levels
Autism spectrum disorder
22,916 European ancestry cases, 37 African ancestry cases, 83 East Asian ancestry cases, 1,567 cases, 32,504 European ancestry controls, 37 African ancestry controls, 83 East Asian ancestry controls, 1,567 controls
4,535 European ancestry cases, 37 African ancestry cases, 83 East Asian ancestry cases, 1,567 cases, 4,535 European ancestry controls, 37 African ancestry controls, 83 East Asian ancestry controls, 1,567 controls
22,916 European ancestry cases, 32,504 European ancestry controls
Behcet's disease
278 Spanish ancestry cases, 1,517 Spanish ancestry controls
up to 130 Spanish ancestry cases, up to 605 Spanish ancestry controls
circulating leptin levels
56,802 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American individuals
Exome genotyping array [Illumina HumanExome BeadChip]
23,861 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American men
32,940 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American women
49,909 European ancestry individuals
21,921 European ancestry men
27,987 European ancestry women
circulating leptin levels adjusted for BMI
56,708 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American individuals
23,822 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American men
32,886 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American women
49,830 European ancestry individuals
21,883 European ancestry men
27,947 European ancestry women
Neuroblastoma (pediatric)
296 Korean ancestry child cases, 1,000 Korean ancestry adult controls
Shoulder impingement syndrome
7,252 European ancestry individuals
PR interval
271,570 European ancestry individuals
Affymetrix, Illumina [at least 167995] (imputed)
271,570 European ancestry individuals, 8,173 African American individuals, 12,823 Hispanic/Latino individuals
Autoimmune traits
1,383 Danish ancestry cases, 62,656 Danish ancestry controls
Mental disorder
43,902 Danish ancestry cases, 19,790 Danish ancestry controls
Autoimmune disease (without mental disorder)
347 Danish ancestry cases, 62,656 Danish ancestry controls
Mental disorder (without autoimmune disease)
42,866 Danish ancestry cases, 19,790 Danish ancestry controls
Autoimmune disease and mental disorder
1,036 Danish ancestry cases, 19,790 Danish ancestry controls
Serum uric acid levels
6,881 Korean ancestry individuals
3,914 Korean ancestry individuals
Affymetrix, Illumina [6129701] (imputed)
Parental lifespan
at least 500,193 European ancestry offspring
Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis)
at least 837,415 European ancestry individuals
Keratinocyte cancer (MTAG)
669,243 European ancestry individuals
323,345 European ancestry individuals
Hepatic steatosis in non-alcoholic fatty liver disease
1,469 European ancestry individuals
504 European ancestry individuals
Liver fibrosis in non-alcoholic fatty acid liver disease
1,481 European ancestry individuals
557 European ancestry individuals
Non-alcoholic steatohepatitis activity score in non-alcoholic fatty liver disease
1,467 European ancestry individuals
501 European ancestry individuals
Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease
Nonalcoholic steatohepatitis
836 European ancestry cases, 17,781 European ancestry controls
Severe liver fibrosis and non-alcoholic fatty liver disease
386 European ancestry cases, 17,781 European ancestry controls
134 European ancestry cases, 945 European ancestry controls
1,483 European ancestry cases, 17,781 European ancestry controls
559 European ancestry cases, 945 European ancestry controls
Polycystic ovary syndrome
1,735 European ancestry cases, 1,007 European, African American and unknown ancestry cases, 27,812 European ancestry controls, 23,626 European, African American and unknown ancestry controls
253 European ancestry cases, 2,161 European ancestry controls
Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism
92 European ancestry cases, 1,481 European ancestry controls
2,425 European ancestry cases, 5,449 European ancestry controls
1,951 European ancestry cases, 4,599 European ancestry controls
Dietary fat liking
331 European ancestry individuals, 50 African ancestry individuals, 19 individuals
Clozapine concentration in schizophrenia
3,473 European ancestry individuals
N-desmethylclozapine concentration in schizophrenia
Clozapine-to-N-desmethylclozapine metabolic ratio in schizophrenia
Septic shock (28-day mortality)
90 European ancestry cases, 403 European ancestry controls
Septic shock (90-day mortality)
112 European ancestry cases, 381 European ancestry controls
Septic shock resolution
459 European ancestry cases, 34 European ancestry controls
Septic shock
493 European ancestry cases, 2,442 European ancestry controls
Persistent chemotherapy-induced alopecia in breast cancer
51 European ancestry cases, 122 European ancestry controls
20 European ancestry cases, 22 European ancestry controls
Early-onset ischemic stroke
330 African American cases, 393 European ancestry cases, 298 African American controls, 428 European ancestry controls
2,463 African American or Afro-Caribbean cases, 2,306 African American or Afro-Caribbean controls
1,106 Japanese American cases, 1,093 Japanese American controls
1,081 Hispanic or Latin American cases, 1,066 Hispanic or Latin American controls
Theta EEG coherence
6,644 European ancestry individuals, 2,166 African American individuals
Cognitive decline
185 MCI cases, 135 AD cases, 94 controls
39 MCI cases, 11 AC cases, 22 controls
Leukoderma in response to rhododendrol
147 Japanese ancestry cases, 112 Japanese ancestry controls
6,872 European ancestry cases, 150,008 European ancestry controls
Self-harm ideation
23,192 European ancestry cases, 133,524 European ancestry controls
Gestational insulin sensitivity
1,126 Afro-Caribbean individuals, 1,380 European ancestry individuals, 830 Mexican-American individuals, 1,192 Thai ancestry individuals
Autism spectrum disorder (MTAG)
60,817 individuals
Depressive symptoms (MTAG)
955,012 individuals
Bipolar disorder (MTAG)
65,682 individuals
Schizophrenia (MTAG)
67,764 individuals
55,374 individuals
Attention deficit hyperactivity disorder (MTAG)
61,421 individuals
46,350 individuals
Depressive symptoms
688,809 individuals
41,653 individuals
65,967 individuals
Brugada syndrome
154 Thai cases, 432 Thai controls
Fasting triglyceride levels
5,630 individuals
Postprandial triglyceride levels
Postprandial triglyceride response
Leg fat mass (lean adjusted)
9,684 European ancestry individuals, 1,541 Han Chinese ancestry individuals, 847 African American individuals, 445 Hispanic individuals
370,097 European ancestry individuals
Affymetrix, Illumina [6879267] (imputed)
Leg lean mass (fat adjusted)
Leg fat mass and leg lean mass (pleiotropy)
Liver fat content (MRI proton density fat fraction measure)
14,440 European ancestry individuals
Liver fibrosis and steatohepatitis severity (MRI cT1 measure)
Spontaneous coronary artery dissection
484 European ancestry cases, 1,477 European ancestry controls
183 European ancestry cases, 340 European ancestry controls
Myocardial fractal dimension (slice 1)
18,096 European individuals
Myocardial fractal dimension (slice 2)
Myocardial fractal dimension (slice 3)
Myocardial fractal dimension (slice 4)
Myocardial fractal dimension (slice 5)
Myocardial fractal dimension (slice 6)
Myocardial fractal dimension (slice 7)
Myocardial fractal dimension (slice 8)
Myocardial fractal dimension (slice 9)
Myocardial fractal dimension (slices 1-9)
Leprosy
1,749 Vietnamese ancestry cases
1,181 Vietnamese ancestry cases, 688 Vietnamese ancestry controls
Deep white matter hyperintensities
16,832 European ancestry individuals, 736 African American individuals, 658 Hispanic individuals
8,428 European and unknown ancestry individuals
Periventricular white matter hyperintensities
Age-related macular degeneration
3,544 European ancestry cases, 44,521 European ancestry controls
White matter microstructure (mean diusivities)
17,706 European ancestry individuals
White matter microstructure (axial diusivities)
White matter microstructure (radial diusivities)
White matter microstructure (mode of anisotropy)
White matter microstructure (fractional anisotropy)
Rapid automised naming of digits
2,563 European ancestry individuals
Rapid automised naming of pictures
2,562 European ancestry individuals
Short-term memory (digit-span task)
2,591 European ancestry individuals
Non-word reading
3,409 European ancestry individuals
Word spelling
3,399 European ancestry individuals
Word reading
3,468 European ancestry individuals
Phoneme awareness
3,093 European ancestry individuals
Reading ability (multivariate)
up to 3,468 European ancestry individuals
Rapid automised naming of letters
Male puberty timing (early vs. average onset facial hair)
13,226 European ancestry early onset individuals, 161,175 European ancestry average onset individuals
Male puberty timing (late vs. average onset facial hair)
26,066 European ancestry late onset individuals, 161,175 European ancestry average onset individuals
Male puberty timing (early vs. average onset voice breaking)
8,245 European ancestry early onset individuals, 172,138 European ancestry average onset individuals
Male puberty timing (late vs. average onset voice breaking)
11,334 European ancestry late onset individuals, 172,138 European ancestry average onset individuals
Male puberty timing (age at voice breaking MTAG)
205,354 European ancestry individuals
Adverse response to chemotherapy (amenorrhea) in breast cancer
457 European ancestry amenorrheic cases, 711 European ancestry post-chemotherapy menses cases
Medial temporal lobe substructure volumes
134 European ancestry individuals
Emphysema annual change measurement in smokers (adjusted lung density)
4,427 European ancestry individuals, 1,158 African American individuals
Emphysema annual change measurement in smokers (percent low attenuation area)
Nicotine dependence
28,677 European ancestry individuals, 9,925 African American individuals
Affymetrix, Illumina [~ 18000000] (imputed)
103,976 European ancestry individuals
Affymetrix, Illumina [1009208] (imputed)
Depressive symptoms x stressful life events interaction (1df test)
Depressive symptoms x stressful life events interaction (2df test)
Depressive symptoms x dependent stressful life events interaction (1df test)
4,919 European ancestry individuals
Depressive symptoms x dependent stressful life events interaction (2df test)
Depressive symptoms x independent stressful life events interaction (1df test)
Depressive symptoms x independent stressful life events interaction (2df test)
Pandemrix-induced narcolepsy
41 European ancestry cases, 1 case, 4,891 European ancestry controls
31 European ancestry cases, 1 case, 7,125 European and other ancestry controls
Diabetic kidney disease in diabetes
5,908 European ancestry cases, 4,967 European ancestry controls
4,579 European ancestry cases, 7,777 European ancestry controls, 7,272 Asian cases, 8,775 Asian controls, 465 Chinese ancestry cases, 154 Chinese ancestry controls, 156 Indian ancestry cases, 66 Indian ancestry controls, 202 Malay ancestry cases, 21 Malay ancestry controls
Affymetrix, Illumina [up to 9343778] (imputed)
Chronic kidney disease in type 2 diabetes
3,094 European ancestry cases, 2,906 European ancestry controls
5,406 European ancestry cases, 8,744 European ancestry controls, 2,964 Asian cases, 3,323 Asian controls, 207 Chinese ancestry cases, 273 Chinese ancestry controls, 58 Indian ancestry cases, 107 Indian ancestry controls, 103 Malay ancestry cases, 56 Malay ancestry controls controls
Chronic kidney disease in diabetes
5,447 European ancestry cases, 4,717 European ancestry controls
5,406 European ancestry cases, 8,744 European ancestry controls, 2,964 Asian cases, 3,323 Asian controls, 207 Chinese ancestry cases, 273 Chinese ancestry controls, 58 Indian ancestry cases, 107 Indian ancestry controls, 103 Malay ancestry cases, 56 Malay ancestry controls
Chronic kidney disease and diabetic kidney disease in type 2 diabetes
408 European ancestry cases, 1,890 European ancestry controls
1,408 European ancestry cases, 3,840 European ancestry controls, 268 Asian cases, 632 Asian controls, 75 Chinese ancestry cases, 119 Chinese ancestry controls
Chronic kidney disease and diabetic kidney disease in diabetes
1,525 European ancestry cases, 3,908 European ancestry controls
End-stage renal disease in type 2 diabetes
371 European ancestry cases, 2,076 European ancestry controls
1,089 European ancestry cases, 5,311 European ancestry controls, 877 Asian cases, 4,861 Asian controls, 20 Chinese ancestry cases, 149 Chinese ancestry controls
End-stage renal disease in diabetes
1,181 European ancestry cases, 4,474 European ancestry controls
Late diabetic kidney disease in type 2 diabetes
1,339 European ancestry cases, 2,372 European ancestry controls
2,891 European ancestry cases, 6,962 European ancestry controls, 3,755 Asian cases, 10,160 Asian controls, 178 Chinese ancestry cases, 154 Chinese ancestry controls, 39 Indian ancestry cases, 64 Indian ancestry controls
Late diabetic kidney disease in diabetes
3,096 European ancestry cases, 4,967 European ancestry controls
Early diabetic kidney disease in type 2 diabetes
1,989 European ancestry cases, 2,238 European ancestry controls
832 European ancestry cases, 2,653 European ancestry controls, 1,518 Asian cases, 3,990 Asian controls, 286 Chinese ancestry cases, 154 Chinese ancestry controls, 114 Indian ancestry cases, 66 Indian ancestry controls, 116 Malay ancestry cases, 21 Malay ancestry controls
Early diabetic kidney disease in diabetes
2,795 European ancestry cases, 4,831 European ancestry controls
Glomerular filtration rate in type 2 diabetes
9,197 European ancestry individuals
9,333 European ancestry individuals, 7,405 Asian individuals, 975 Chinese ancestry individuals, 384 Indian ancestry individuals, 307 Malay ancestry individuals
Glomerular filtration rate in diabetes
13,158 European ancestry individuals
Diabetic kidney disease in type 2 diabetes (ESRD vs. no ESRD)
371 European ancestry cases with end-stage renal disease, 4,471 European ancestry cases without end-stage renal disease
1,640 European ancestry cases with end-stage renal disease, 7,803 European ancestry cases without end-stage renal disease, 877 Asian cases with end-stage renal disease, 4,510 Asian cases without end-stage renal disease, 20 Chinese ancestry cases with end-stage renal disease, 398 Chinese ancestry cases without end-stage renal disease
Diabetic kidney disease in diabetes (ESRD vs. no ESRD)
1,184 European ancestry cases with end-stage renal disease, 8,466 European ancestry cases without end-stage renal disease
Diabetic kidney disease in type 2 diabetes
3,345 European ancestry cases, 2,372 European ancestry controls
Gut microbiota relative abundance (Bifidobacterium)
Gut microbiota relative abundance (Bacteroides)
Gut microbiota relative abundance (Parabacteroides)
Gut microbiota relative abundance (Prevotella)
Gut microbiota relative abundance (Streptococcus)
Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae)
Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales)
Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae)
Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae)
Gut microbiota relative abundance (Blautia)
Gut microbiota relative abundance (Coprococcus)
Gut microbiota relative abundance (Dorea)
Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae)
Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae)
Gut microbiota relative abundance (Faecalibacterium)
Gut microbiota relative abundance (Oscillospira)
Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae)
Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales)
Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae)
Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae)
Gut microbiota relative abundance (Sutterella)
527 Japanese ancestry men
14,026 Korean ancestry individuals
Post-traumatic stress disorder (re-experiencing symptoms)
146,660 European ancestry individuals, 19,983 African American individuals
117,900 European ancestry individuals
Blood cell traits (multivariate analysis)
up to 6,407 Sub-Saharan African ancestry individuals
White blood cell count
1,625 Sub-Saharan African ancestry individuals
Red blood cell count
Mean corpuscular volume
Mean corpuscular hemoglobin
Mean corpuscular hemoglobin concentration
Red cell distribution width
Hematocrit
Hemoglobin
Neutrophil count
1,415 Sub-Saharan African ancestry individuals
Platelet count
Lymphocyte counts
1,565 Sub-Saharan African ancestry individuals
Monocyte count
Basophil count
Eosinophil counts
1,555 Sub-Saharan African ancestry individuals
Mean platelet volume
1,624 Sub-Saharan African ancestry individuals
Thyroid stimulating hormone levels
119,715 European ancestry individuals
Cognitive impairment and C-reactive protein levels (pleiotropy)
355 European ancestry cases, 6,190 European ancestry controls
Cognitive impairment and LDL levels (pleiotropy)
Cognitive impairment and total cholesterol levels (pleiotropy)
Cognitive impairment
C-reactive protein levels
6,545 European ancestry individuals
High density lipoprotein cholesterol levels
Serum total cholesterol levels
Particulate matter induced DNA damage
307 Han Chinese ancestry individuals
Resistant hypertension
297 European ancestry cases, 226 Hispanic cases, 623 European ancestry controls, 633 Hispanic controls
1,946 European ancestry cases, 471 European ancestry controls
226 European ancestry cases, 143 Hispanic cases, 431 European ancestry controls, 394 Hispanic controls
71 European ancestry cases, 83 Hispanic cases, 192 European ancestry controls, 239 Hispanic controls
36,614 Japanese ancestry cases, 155,150 Japanese ancestry controls
2,809 Japanese ancestry cases, 5,592 Japanese ancestry controls
2,115 Japanese ancestry cases, 2,519 Japanese ancestry controls
Type 2 diabetes nephropathy including microalbuminuria
at least 2,809 Japanese ancestry cases, 5,592 Japanese ancestry controls
at least 2,115 Japanese ancestry cases, 2,519 Japanese ancestry controls
Alcohol consumption
480,842 European ancestry individuals
Affymetrix, Illumina [~ 7100000] (imputed)
Urine specific gravity measurement
139,555 Icelandic ancestry individuals (includes non-array genotyped, whole-genome imputed individuals)
Glucosuria (moderate to severe)
6,109 Icelandic ancestry cases, 135,512 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Glucosuria (mild)
4,748 Icelandic ancestry cases, 135,512 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Ketonuria
41,130 Icelandic ancestry cases, 95,568 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Ketonuria (moderate to severe)
21,803 Icelandic ancestry cases, 95,568 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Ketonuria (mild)
19,327 Icelandic ancestry cases, 95,568 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Proteinuria
54,009 Icelandic ancestry cases, 91,538 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Proteinuria (moderate to severe)
25,317 Icelandic ancestry cases, 91,538 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Proteinuria (mild)
28,692 Icelandic ancestry cases, 91,538 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Hematuria
68,051 Icelandic ancestry cases, 68,903 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Hematuria (moderate to severe)
49,212 Icelandic ancestry cases, 68,903 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Hematuria (mild)
18,839 Icelandic ancestry cases, 68,903 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Urine pH measurement
149,899 Icelandic ancestry individuals (includes non-array genotyped, whole-genome imputed individuals)
Low urine pH
35,897 Icelandic ancestry cases, 112,302 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Signs of urinary tract infection (nitrites and leukocyte esterase)
13,322 Icelandic ancestry cases, 66,528 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Glucosuria
10,857 Icelandic ancestry cases, 135,512 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
Ulcerative colitis
7,760 European ancestry cases, 16,065 European ancestry controls
5,054 European ancestry cases, 450 cases, 162,024 European ancestry controls, 3,905 controls
Affymetrix, Illumina [~ 12000000] (imputed)
Atrial fibrillation
2,987 European ancestry cases, 117,299 European ancestry controls
118,811 European ancestry cases, 327,427 European ancestry controls, 127,552 cases, 233,763 controls
414,055 European ancestry cases, 892,299 European ancestry controls
Anorexia nervosa
16,992 European ancestry cases, 55,525 European ancestry controls
Affymetrix, Illumina [at least 8111819] (imputed)
Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A
183 European ancestry cases severe cases, 147 European ancestry mild cases
55 Asian ancestry severe cases, 25 Asian ancestry mild cases
Systemic sclerosis
9,095 European ancestry cases, 17,584 European ancestry controls
10,074 European ancestry cases, 103,164 European ancestry controls
480 European ancestry cases, 1,208 European ancestry controls
Substance use disorder
249 Arabian ancestry cases, 253 Arabian ancestry controls
415 European ancestry cases, 105 European ancestry controls
Anti-anoctamin 2 antibody levels
11,936 European ancestry individuals
Annualised percent change of cerebrospinal fluid AB1-42 levels
321 European ancestry individuals
Toxicity response to radiotherapy in prostate cancer (rectal bleeding) (time to event)
3,379 European ancestry individuals
Affymetrix, Illumina [~ 6000000] (imputed)
Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event)
3,470 European ancestry individuals
Toxicity response to radiotherapy in prostate cancer (hematuria) (time to event)
3,619 European ancestry individuals
538 Japanese ancestry individuals
Response to radiotherapy in prostate cancer (overall toxicity)
3,871 European ancestry individuals
Toxicity response to radiotherapy in prostate cancer (increased urinary frequency) (time to event)
3,782 European ancestry individuals
Alzheimer's disease
212 European ancestry cases, 333 European ancestry controls
46 European ancestry cases, 257 European ancestry controls
Mild cognitive impairment
326 European ancestry cases, 333 European ancestry controls
448 European ancestry cases, 257 European ancestry controls
Amyloid status (abnormal vs normal)
455 European ancestry cases, 416 European ancestry controls
361 European ancestry cases, 257 European ancestry controls
Central cerebrospinal fluid amyloid beta 42 to 40 ratio (abnormal vs normal)
418 European ancestry cases, 259 European ancestry controls
Local cerebrospinal fluid amyloid beta 42 levels (abnormal vs normal)
392 European ancestry cases, 334 European ancestry controls
340 European ancestry cases, 238 European ancestry controls
Amyloid pathology
890 European ancestry individuals
578 European ancestry individuals
Central cerebrospinal fluid amyloid beta 42 levels
677 European ancestry individuals
Central cerebrospinal fluid amyloid beta 38 levels
675 European ancestry individuals
Central cerebrospinal fluid amyloid beta 40 levels
Central cerebrospinal fluid amyloid beta 42 to 40 ratio
Local cerebrospinal fluid t-tau levels (abnormal vs normal)
378 European ancestry cases, 346 European ancestry controls
Local cerebrospinal fluid p-tau levels (abnormal vs normal)
354 European ancestry cases, 372 European ancestry controls
Cerebrospinal fluid t-tau levels
723 European ancestry individuals
571 European ancestry individuals
Cerebrospinal fluid p-tau levels
726 European ancestry individuals
576 European ancestry individuals
same-sex sexual behaviour
329,546 European ancestry males
2,196 European ancestry males, up to 9,109 European ancestry twins
338,218 European ancestry females
2,529 European ancestry females, up to 9,109 European ancestry twins
329,546 European ancestry males, 338,218 European ancestry females
2,196 European ancestry males, 2,529 European ancestry females, 9,109European ancestry twins
proportion of same-sex sexual behaviour among non-heterosexuals
7,675 European ancestry males
5,838 European ancestry females
at least 7,675 European ancestry males, at least 5,838 European ancestry females
188,825 European ancestry males
220,170 European ancestry females
188,825 European ancestry males, 220,170 European ancestry females
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy)
328,917 individuals with educational attainment measurements, 107,207 individuals with cognitive ability measurements, 77,096 European ancestry schizophrenia cases, 43,456 European ancestry controls
Sensation seeking
22,745 European ancestry individuals
Impulsivity
21,495 European ancestry individuals
Lack of premeditation
22,774 European ancestry individuals
Positive urgency
22,738 European ancestry individuals
Negative urgency
22,795 European ancestry individuals
Lack of perseverance
22,861 European ancestry individuals
Impulsivity (attentional)
21,876 European ancestry individuals
Impulsivity (motor)
21,806 European ancestry individuals
Impulsivity (non-planning)
21,786 European ancestry individuals
Drug experimentation measurement
22,572 European ancestry individuals
Fish intake frequency
12,603 Japanese ancestry individuals
Neurological blood protein biomarker levels
750 European ancestry individuals
2,342 Sub-Saharan African ancestry cases, 2,889 Sub-Saharan African ancestry controls, 8,599 African American individuals
2,342 Sub-Saharan African ancestry cases, 2,889 Sub-Saharan African ancestry controls
1,602 South African Zulu ancestry cases, 976 South African Zulu ancestry controls
Psychological distress
3,981 Japanese ancestry cases, 6,349 Japaneses ancestry controls
Male-pattern baldness
52,874 British ancestry males
Cardiometabolic traits
up to 19,292 Finnish ancestry individuals
24,776 Finnish ancestry individuals
6,125 Icelandic ancestry individuals
Intraocular pressure (corneal compensated)
Intraocular pressure (Goldman correlated)
1,459 Icelandic ancestry individuals
Corneal endothelial cell density
Corneal endothelial cell size variation coefficient
Corneal endothelial cell shape (percentage of hexagonally shaped cells)
Priapism in sickle cell disease
169 European, African, Hispanic or unknown ancestry cases, 433 European, African, Hispanic or unknown ancestry controls
Percentage of invited food questionnaires completed
300,639 European ancestry individuals
Acceptance of an invitation to wear a physical activity monitor
96,035 European ancestry cases, 119,092 European ancestry controls
Acceptance of an invitation to participate in a mental health questionnaire
146,074 European ancestry cases, 148,713 European ancestry controls
Completion of the aide-memoire
361,501 European ancestry cases, 89,535 European ancestry controls
Participation in an health questionnaire (not invited vs invited)
336,633 European ancestry cases, 114,464 European ancestry controls
Airway obstruction (FEV1/FVC<70%) in never smokers
77 European ancestry cases, 355 European ancestry controls
Airway obstruction (FEV1/FVC<lower limit of normal) in ever smokers
212 European ancestry cases, 611 European ancestry controls
Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers
49 European ancestry cases, 383 European ancestry controls
Airway obstruction (FEV1/FVC<70%) in ever smokers
287 European ancestry cases, 536 European ancestry controls
1,107 European ancestry cases, 3,748 European ancestry controls
836 European ancestry cases, 2,298 European ancestry controls
548 European ancestry cases, 4,522 European ancestry controls
230 European ancestry cases, 1,736 European ancestry controls
833 European ancestry cases, 4,022 European ancestry controls
459 European ancestry cases, 2,675 European ancestry controls
401 European ancestry cases, 4,669 European ancestry controls
92 European ancestry cases, 1,874 European ancestry controls
Alzheimer's disease or family history of Alzheimer's disease
472,868 European ancestry individuals
Family history of Alzheimer's disease
408,942 European ancestry individuals
Glioma
992 Han Chinese ancestry cases, 1,008 Han Chinese ancestry controls
2,105 Han Chinese ancestry cases, 3,374 Han Chinese ancestry controls
Tuberculosis
242 South African admixed female cases, 168 South African admixed male cases, 223 South African admixed female controls, 182 South African admixed male controls
Tuberculosis (SNP x SNP interaction)
1,106 European ancestry cases, 8,571 European ancestry controls
235 European ancestry individuals
Aspartate aminotransferase levels in non-alcoholic fatty liver disease
1,075 European ancestry individuals
Alanine aminotransferase levels in non-alcoholic fatty liver disease
Nonalcoholic fatty liver disease (SNP x SNP interaction)
Severe diabetic retinopathy in type 2 diabetes
560 Scottish ancestry proliferative or severe background retinopathy cases, 4,106 Scottish ancestry mild or no retinopathy controls
Affymetrix, Illumina [6585471] (imputed)
1,102 Old Order Amish (founder/genetic isolate) individuals
798 Old Order Amish (founder/genetic isolate) individuals
Targeted genotyping array [Cardio-Metabochip]
Self-reported risk-taking behaviour
83,677 British ancestry cases, 244,662 British ancestry controls
2,764 South Asian ancestry cases, 3,139 African Caribbean ancestry cases, 16,169 European ancestry cases, 3,866 mixed ancestry cases, 4,267 South Asian ancestry controls, 4,341 African Caribbean ancestry controls, 31,814 European ancestry controls, 5,988 mixed ancestry controls
Post-bronchodilator FEV1 x air pollution (CO) interaction in childhood asthma
522 European ancestry children
Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma
88 African-American children
4,126 African ancestry individuals, 5,007 African American individuals
Affymetrix, Illumina [up to 18219730] (imputed)
Lung function x fine particulate matter exposure levels interaction
1,826 Korean ancestry individuals
892 Korean ancestry individuals
Total body bone mineral density
2,286 European ancestry individuals
Bone mineral density (hip)
Femoral neck bone mineral density
Ulna and radius bone mineral density
Bone mineral density (spine)
16,595 European ancestry cases, 523,330 European ancestry controls
Affymetrix, Illumina [43421991] (imputed)
Adenocarcinoma in never smokers
1,837 European ancestry cases, 5,355 European ancestry controls
672 European ancestry cases, 940 European ancestry controls
Lung cancer in never smokers
2,676 European ancestry cases, 5,355 European ancestry controls
960 European ancestry cases, 940 European ancestry controls
Asthma (time to childhood onset) in early life tobacco smoke exposure
3,187 European ancestry individuals
Asthma (childhood onset)
5,086 European ancestry individuals
Asthma (time to childhood onset) x early life tobacco smoke interaction
3,187 European ancestry exposed individuals, 5,086 European ancestry unexposed individuals
Pyridoxal 5'-phosphate levels
2,232 Irish ancestry individuals
Plasma pyridoxal phosphate to pyridoxal ratio
Pyridoxal levels
4-pyridoxic acid levels
PAr index (pyridoxic acid/(pyridoxal 5′-phosphate + pyridoxal))
Blood metabolite levels
2,076 European ancestry individuals
1,528 European ancestry individuals
575 Han Chinese ancestry cases, 1,707 Han Chinese ancestry controls
535 Han Chinese ancestry cases, 9,145 Han Chinese ancestry controls
Diverticular disease
27,444 British ancestry cases, 382,284 British ancestry controls
Coffee consumption (cups per day)
227,666 British ancestry individuals
85,554 European ancestry cases, 10,368 African ancestry cases, 8,611 East Asian ancestry cases, 2,714 Hispanic cases, 91,972 European ancestry controls, 10,986 African ancestry controls, 18,809 East Asian ancestry controls, 5,239 Hispanic controls
Affymetrix, Illumina [29235255] (imputed)
85,554 European ancestry cases, 91,972 European ancestry controls
6,852 European ancestry cases, 193,117 European ancestry controls
Affymetrix, Illumina [20400945] (imputed)
10,368 African ancestry cases, 10,986 African ancestry controls
Affymetrix, Illumina [18877980] (imputed)
8,611 East Asian ancestry cases, 18,809 East Asian ancestry controls
Affymetrix, Illumina [10186136] (imputed)
2,714 Hispanic cases, 5,239 Hispanic controls
Affymetrix, Illumina [11334207] (imputed)
Varicose veins
9,577 British ancestry cases, 327,959 British ancestry controls
Lipoprotein (a) levels
293,274 White ancestry individuals
5,465 White ancestry individuals, 6,101 South Asian ancestry individuals, 2,510 Sub-Saharan African ancestry individuals, 3,207 Black Caribbean ancestry individuals
421,466 European ancestry individuals
Difficulty awakening
451,872 European ancestry individuals
Colorectal cancer x fine particulate matter exposure levels interaction
590 European ancestry cases, 55 Black cases, 9 Hispanic cases, 28 Asian ancestry cases, 5 cases, 12,715 European ancestry controls, 1,153 Black controls, 37 Hispanic controls, 94 Asian ancestry controls, 15 controls
484 Sub-Saharan African ancestry cases, 179 South African Coloured ancestry cases, 450 African American cases, 380 Sub-Saharan African ancestry controls, 96 South African Coloured ancestry controls, 1350 African American controls
1,993 Sub-Saharan African ancestry cases, 2,595 African American cases, 1,730 Sub-Saharan African ancestry controls, 2,813 African American controls
Cerebrospinal fluid AB1-42 levels
235 early mild cognitive impairment cases, 249 late mild cognitive impairment cases, 47 Alzheimer's disease cases, 281 controls.
Cerebrospinal fluid p-Tau181p:AB1-42 ratio
Cognitive impairment test score
91,105 European ancestry individuals
Sedentary behaviour duration
Physical activity (walking duration)
Physical activity (moderate intensity activity duration)
Physical activity (overall physical activity time)
Breakfast cereal skipping frequency
193,860 European ancestry individuals
Breakfast skipping
1,359 European ancestry cases, 10,604 European ancestry controls
Affymetrix, Illumina [up to 38050714] (imputed)
Age at menopause
7,611 European ancestry individuals
3,082 individuals
Anti-drug antibodies in autoimmune disease (time to event)
457 European ancestry individuals
Circulating fibroblast growth factor 21 levels
4,201 Taiwanese ancestry individuals
Circulating fibroblast growth factor 23 levels
Hyperglycemia
11,794 European ancestry women
Hyperglycemia in obesity
3,431 European ancestry women
Hyperglycemia in non-obese individuals
8,363 European ancestry women
Hyperglycemia in lower physical activity
6,818 European ancestry women
Hyperglycemia in higher physical activity
4,976 European ancestry women
Hyperglycemia in more-fat diet
10,707 European ancestry women
Hyperglycemia in less-fat diet
1,087 European ancestry women
Homeostasis model assessment of insulin resistance in obesity
Homeostasis model assessment of insulin resistance in non-obese individuals
Homeostasis model assessment of insulin resistance in higher physical activity
Homeostasis model assessment of insulin resistance in lower physical activity
Homeostasis model assessment of insulin resistance in more-fat diet
Homeostasis model assessment of insulin resistance in less-fat diet
Hyperglycemia x BMI interaction
8,363 European ancestry non-obese women, 3,431 European ancestry obese women
Hyperglycemia x physical activity interaction
4,976 European ancestry active women, 6,818 European ancestry inactive women
Hyperglycemia x saturated fatty acids interaction
1,087 European ancestry less-fat diet women, 10,707 European ancestry more-fat diet women
Hyperinsulinemia
Homeostasis model assessment of insulin resistance
Hyperinsulinemia x BMI interaction
Homeostasis model assessment of insulin resistance x BMI interaction
Hyperinsulinemia x physical activity interaction
Homeostasis model assessment of insulin resistance x physical activity interaction
Hyperinsulinemia x saturated fatty acids interaction
Homeostasis model assessment of insulin resistance x saturated fatty acids interaction
Hyperinsulinemia in obesity
Walking pace
450,967 European ancestry individuals
Hyperinsulinemia in non-obese individuals
Hyperinsulinemia in higher physical activity
Hyperinsulinemia in lower physical activity
Hyperinsulinemia in more-fat diet
Hyperinsulinemia in less-fat diet
Fasting plasma glycodeoxycholate 3-O-glucuronide concentration
356 Finnish ancestry individuals
Fasting plasma glycochenodeoxycholate 3-O-glucuronide concentration
Frontal fibrosing alopecia
1,016 European ancestry cases, 4,145 European ancestry controls
80,003 European ancestry individuals
Triiodothyronine levels
629 Croatian individuals, 510 Korculan (founder/genetic isolate) individuals, 590 Vis (founder/genetic isolate) individuals
Thyroxine levels
596 Croatian individuals, 510 Korculan (founder/genetic isolate) individuals, 609 Vis (founder/genetic isolate) individuals
626 Croatian individuals, 509 Korculan (founder/genetic isolate) individuals, 596 Vis (founder/genetic isolate) individuals
Triiodothyronine levels and thyroxine levels
Up to 1,729 Croatian, Korculan (founder/genetic isolate) and Vis (founder/genetic isolate) individuals
Dilated cardiomyopathy
5,521 cases, 397,323 controls
Affymetrix, Illumina [up to 7736182] (imputed)
19,260 European ancestry individuals
Left ventricular mass to end-diastolic volume ratio
Left ventricular mass
Left ventricular global circumferential strain
Left ventricular global radial strain
Left ventricular global longitudinal strain
Left ventricle wall thickness
Hypertrophic cardiomyopathy (MTAG)
1,733 European ancestry cases, 6,628 European ancestry controls
Dilated cardiomyopathy (MTAG)
Left ventricular ejection fraction (MTAG)
Left ventricular mass to end-diastolic volume ratio (MTAG)
Left ventricular mass (MTAG)
Left ventricular end-diastolic volume (MTAG)
Left ventricular end-systolic volume (MTAG)
Left ventricular global circumferential strain (MTAG)
Left ventricular global radial strain (MTAG)
Left ventricular global longitudinal strain (MTAG)
Left ventricle wall thickness (MTAG)
Hypertrophic cardiomyopathy
2,694 European ancestry cases, 47,486 European ancestry controls
Carpal tunnel syndrome
12,312 European ancestry cases, 389,344 European ancestry controls
Psychological resilience (outcome-based) in high deployment stress exposure
581 European ancestry cases and controls
Psychological resilience (self-assessed)
11,473 European ancestry individuals
Psychological resilience (outcome-based)
1,558 European ancestry resilient cases, 381 European ancestry controls with post-deployment mental disorder
Adult asthma
731 Korean ancestry cases, 5,915 Korean ancestry controls
Asthma-chronic obstructive pulmonary disease overlap syndrome in asthma
228 Korean ancestry asthma-COPD overlap syndrome cases, 731 Korean ancestry asthma cases
Asthma-chronic obstructive pulmonary disease overlap syndrome
228 Korean ancestry cases, 5,915 Korean ancestry controls
Motor composite score
502 Bangladeshi ancestry infants, 462 Hispanic or Latin American infants
Mental composite score
Sleep duration (short sleep)
106,192 European ancestry cases, 305,742 European ancestry controls
47,180 adults, 10,554 children or adolescents
Sleep duration (long sleep)
34,184 European ancestry cases, 305,742 European ancestry controls
446,118 European ancestry individuals
Large artery stroke
up to 2,286 European ancestry cases, up to 376 South Asian cases, up to 8,884 European ancestry controls, up to 978 South Asian controls
4,831 European ancestry cases, 115,455 European ancestry controls
up to 60,801 European and unknown ancestry cases, up to 123,504 European and unknown ancestry controls
5,426 Icelandic ancestry cases, 245,951 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
5,970 Danish ancestry cases, 3,020 Danish ancestry controls
Diverticulitis
2,764 Icelandic ancestry cases, 245,951 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
37,845 European ancestry cases, 26,124 cases, 775,530 European ancestry controls, 48,339 controls
45,570 European ancestry cases, 26,577 cases, 775,530 European ancestry controls, 48,339 controls
Suicidal ideation
79 European ancestry cases, 59 cases, 654 European ancestry controls, 779 controls
52 European ancestry cases, 70 cases, 680 European ancestry controls, 767 controls
Mouth ulcers
47,079 British or unknown ancestry cases, 414,027 British or unknown ancestry controls
98,298 cases, 247,446 controls
Affymetrix, Illumina [9851866] (imputed)
Coronary artery disease in type 1 diabetes
941 European ancestry cases, 3,928 European ancestry controls
434 cases, 3,123 controls
17,127 African American individuals, 21,955 Hispanic/Latino individuals, 4,647 Asian ancestry individuals, 3,936 Native Hawaiian ancestry individuals, 645 Native American ancestry individuals, 1,025 individuals
Chronic kidney disease
1,533 African American cases, 1,339 Hispanic/Latino cases, 575 Asian ancestry cases, 608 Native Hawaiian ancestry cases, 42 Native American ancestry cases, 57 cases, 13,989 African American controls, 19,581 Hispanic/Latino controls, 3,549 Asian ancestry controls, 2,892 Native Hawaiian ancestry controls, 597 Native American ancestry controls, 965 controls
Smoking behaviour (cigarettes smoked per day)
7,171 African American individuals, 4,198 Hispanic/Latino individuals, 1,918 Asian ancestry individuals, 2,176 Native Hawaiian ancestry individuals, 288 Native American ancestry individuals, 111 individuals
11,862 African American individuals, 15,837 Hispanic/Latino individuals, 3,764 Asian ancestry individuals, 3,857 Native Hawaiian ancestry individuals, 582 Native American ancestry individuals
11,380 African American individuals, 21,549 Hispanic/Latino individuals, 1,086 Asian ancestry individuals, 636 Native American ancestry individuals, 782 individuals
Estimated glomerular filtration rate
8,261 African American individuals, 18,548 Hispanic/Latino individuals, 150 Asian ancestry individuals, 602 Native American ancestry individuals, 339 individuals
End-stage renal disease
326 African American cases, 208 Hispanic/Latino cases, 24 Asian ancestry cases, 21 Native Hawaiian ancestry cases, 1 Native American ancestry case, 22 cases, 8,739 African American controls, 16,197 Hispanic/Latino controls, 3,576 Asian ancestry controls, 2,925 Native Hawaiian ancestry controls, 52 Native American ancestry controls, 970 controls
Fasting blood glucose
6,457 African American individuals, 13,556 Hispanic/Latino individuals, 1,918 Asian ancestry individuals, 1,400 Native Hawaiian ancestry individuals, 412 Native American ancestry individuals, 168 individuals
Fasting blood insulin
5,525 African American individuals, 12,687 Hispanic/Latino individuals, 1,547 Asian ancestry individuals, 1,397 Native Hawaiian ancestry individuals, 395 Native American ancestry individuals
Hemoglobin A1c levels
559 African American individuals, 10,408 Hispanic/Latino individuals, 92 Asian ancestry individuals, 4 Native American ancestry individuals, 115 individuals
10,085 African American individuals, 17,751 Hispanic/Latino individuals, 2,378 Asian ancestry individuals, 1,912 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 333 individuals
11,863 African American cases, 8,663 Hispanic/Latino cases, 3,102 Asian ancestry cases, 2,645 Native Hawaiian ancestry cases, 342 Native American ancestry cases, 508 cases, 5,289 African American controls, 13,273 Hispanic/Latino controls, 1,561 Asian ancestry controls, 1,060 Native Hawaiian ancestry controls, 293 Native American ancestry controls, 542 controls
9,720 African American individuals, 17,373 Hispanic/Latino individuals, 2,316 Asian ancestry individuals, 1,900 Native Hawaiian ancestry individuals, 591 Native American ancestry individuals, 321 individuals
3,750 African American individuals, 15,522 Hispanic/Latino individuals, 128 Asian ancestry individuals, 20 Native American ancestry individuals, 383 individuals
8,850 African American individuals, 18,949 Hispanic/Latino individuals, 541 Asian ancestry individuals, 603 Native American ancestry individuals, 385 individuals
3,360 African American individuals, 13,702 Hispanic/Latino individuals, 129 Asian ancestry individuals, 231 Native American ancestry individuals
QT interval
3,293 African American individuals, 13,698 Hispanic/Latino individuals, 127 Asian ancestry individuals, 230 Native American ancestry individuals
10,137 African American individuals, 17,802 Hispanic/Latino individuals, 2,387 Asian ancestry individuals, 1,915 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 340 individuals
Triglyceride levels
9,980 African American individuals, 17,856 Hispanic/Latino individuals, 2,381 Asian ancestry individuals, 1,915 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 360 individuals
5,971 African American cases, 4,135 Hispanic/Latino cases, 2,004 Asian ancestry cases, 1,534 Native Hawaiian ancestry cases, 167 Native American ancestry cases, 231 cases, 9,630 African American controls, 16,345 Hispanic/Latino controls, 2,572 Asian ancestry controls, 2,017 Native Hawaiian ancestry controls, 452 Native American ancestry controls, 667 controls
8,825 African American individuals, 18,251 Hispanic/Latino individuals, 543 Asian ancestry individuals, 606 Native American ancestry individuals, 383 individuals
Waist-hip ratio
9,140 African American females, 11,555 Hispanic/Latino females, 1,843 Asian ancestry females, 1,715 Native Hawaiian ancestry females, 585 Native American ancestry females
1,146 African American males, 4,917 Hispanic/Latino males, 1,657 Asian ancestry males, 1,346 Native Hawaiian ancestry males
10,286 African American individuals, 16,472 Hispanic/Latino individuals, 3,500 Asian ancestry individuals, 3,061 Native Hawaiian ancestry individuals, 585 Native American ancestry individuals
Early age-related macular degeneration
14,034 European ancestry cases, 91,214 European ancestry controls
Affymetrix, Illumina [11702853] (imputed)
681 Japanese ancestry cases, 17,492 Japanese ancestry controls
Bitter alcoholic beverage consumption
336,448 European ancestry individuals
39,924 European ancestry individuals
Bitter non-alcoholic beverage consumption
85,852 European ancestry individuals
335,909 European ancestry individuals
Tea consumption
336,898 European ancestry individuals
Grapefruit juice consumption
Sweet beverage consumption
Sugar-sweetened beverage consumption
Artificially sweetened beverage consumption
Pure non-grapefruit juice consumption
Bitter beverage consumption
Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention)
1,402 Han Chinese ancestry individuals
Progression-free survival response to gemcitabine in breast cancer
1,621 treated cases, 1,668 untreated cases
Homocysteine level response to multivitamin in cerebral infarction
760 European ancestry treated cases, 773 European ancestry untreated cases
Myeloproliferative neoplasms
1,086 British ancestry cases, 407,155 British ancestry controls, 640 Finnish ancestry cases, 176,259 Finnish ancestry controls
BRCA1/2-negative high-risk breast cancer
1,469 Korean ancestry cases, 5,979 Korean ancestry controls
Affymetrix, Illumina [3378933] (imputed)
Gallstone disease
14,940 British ancestry cases, 322,268 British ancestry controls
1,522 Danish ancestry cases, 18,266 Danish ancestry controls
Inflammatory biomarkers (multivariate analysis)
6,890 Finnish ancestry individuals
Blood protein levels
up to 1,209 European ancestry individuals
Homocysteine levels
1,208 European ancestry individuals
Carotenoid levels
up to 1,200 European ancestry individuals
Diabetes biomarker traits
Hematology traits
Hormone measurements
Circulating inorganic ion levels
Lipid or lipoprotein levels
up to 1,206 European ancestry individuals
Renal system biomarkers
Vitamin levels
Tumor necrosis factor alpha levels
1,167 European ancestry individuals
708 individuals
Vitamin B12 levels
1,175 European ancestry individuals
2,083 individuals
Chloride levels
1,206 European ancestry individuals
4,068 individuals
Severe depressive disorders in coronary artery disease
78 European ancestry cases, 264 European ancestry controls
Severe skin toxicity response to cetuximab in colorectal cancer
36 cases, 246 controls with no or mild skin toxicity
Thiopurine-induced early leukopenia in Crohn's disease
33 Korean ancestry cases, 307 Korean ancestry controls
33 Korean ancestry cases, 325 Korean ancestry controls
Alanine aminotransferase levels
390,812 European ancestry individuals
134,154 East Asian ancestry individuals
Aspartate aminotransferase levels
389,565 European ancestry individuals
134,182 East Asian ancestry individuals
Serum alkaline phosphatase levels
390,964 European ancestry individuals
105,030 East Asian ancestry individuals
Knee osteoarthritis
24,955 European ancestry cases, 378,169 European ancestry controls
Affymetrix, Illumina [up to 17000000] (imputed)
Osteoarthritis (hip)
15,704 European ancestry cases, 378,169 European ancestry controls
Osteoarthritis of the hip or knee
39,427 European ancestry cases, 378,169 European ancestry controls
Osteoarthritis
77,052 European ancestry cases, 378,169 European ancestry controls
Meningococcal C IgG concentrations post childhood immunization
1,203 European ancestry children and adolescents
980 European ancestry children and adolescents
Meningococcal C functional antibody titers post childhood immunization
1,585 European ancestry children and adolescents
779 European ancestry children and adolescents
Tetanus toxoid IgG concentrations post childhood immunization
549 European ancestry children and adolescents
1,303 European ancestry children and adolescents
Haemophilus influenza type b polyribosylribitol phosphate IgG concentrations post childhood immunization
967 European ancestry children and adolescents
1,011 European ancestry children and adolescents
Acute post-radiotherapy pain in breast cancer
136 Hispanic cases, 75 European ancestry cases, 102 African ancestry cases, 45 cases, 265 Hispanic controls, 282 European ancestry controls, 194 African ancestry controls, 45 controls
Non-tuberculous mycobacterial pulmonary disease
403 Korean ancestry cases, 306 Korean ancestry controls
184 Korean ancestry cases, 1680 Korean ancestry controls
Premature ovarian failure
60 Korean ancestry cases, 182 Korean ancestry controls
105 Korean ancestry cases, 217 Korean ancestry controls
Mitochondrial DNA levels
301 Chinese ancestry individuals
Kawasaki disease
1,276 East Asian ancestry cases, 5,086 East Asian ancestry controls
2,152 East Asian ancestry cases, 2,751 East Asian ancestry controls
Affymetrix, Illumina [6265045] (imputed)
Fasting glucose in pregnancy (gestational week 14-16)
517 Scandinavian ancestry individuals
Fasting glucose in pregnancy (gestational week 30-32)
521 Scandinavian ancestry individuals
Two-hour glucose in pregnancy (gestational week 14-16)
506 Scandinavian ancestry individuals
Two-hour glucose in pregnancy (gestational week 30-32)
512 Scandinavian ancestry individuals
General glucose level in pregnancy (gestational week 14-16)
497 Scandinavian ancestry individuals
General glucose level in pregnancy (gestational week 30-32)
Timing of glucose curve peak in pregnancy (gestational week 14-16)
Timing of glucose curve peak in pregnancy (gestational week 30-32)
Femoral neck bone mineral density or type 2 diabetes (pleiotropy)
53,236 European ancestry individuals with bone mineral density data, 26,676 European ancestry type 2 diabetes cases, 132,532 European ancestry controls
Telomere length
492 African American children and adolescents
Alcohol use disorder (total score)
141,932 European ancestry individuals
Alcohol use disorder (consumption score)
121,604 British ancestry individuals
Alcohol use disorder (dependence and problematic use scores)
Parkinson's disease (age at diagnosis)
1,950 European ancestry cases
726 European ancestry cases
Red blood cell folate levels
Serum folate levels
Plasma homocysteine levels
Chronic periodontitis
442 Friuli Venezia Giulia (founder/genetic isolate) cases, 160 Friuli Venezia Giulia (founder/genetic isolate) controls
Chronic periodontitis (slight)
273 Friuli Venezia Giulia (founder/genetic isolate) cases, 160 Friuli Venezia Giulia (founder/genetic isolate) controls
Chronic periodontitis (severe)
169 Friuli Venezia Giulia (founder/genetic isolate) cases, 160 Friuli Venezia Giulia (founder/genetic isolate) controls
Chronic periodontitis (generalised)
235 Friuli Venezia Giulia (founder/genetic isolate) cases, 160 Friuli Venezia Giulia (founder/genetic isolate) controls
Chronic periodontitis (localised)
207 Friuli Venezia Giulia (founder/genetic isolate) cases, 160 Friuli Venezia Giulia (founder/genetic isolate) controls
Intra-individual response time variability (response selection)
857 European ancestry individuals
Intra-individual response time variability (selective attention)
Hepatitis B virus-related hepatocellular carcinoma
195 Han Chinese ancestry cases
97 Han Chinese ancestry cases
Serum urate levels in chronic kidney disease
4,941 European ancestry cases
Gout in chronic kidney disease
1,217 European ancestry cases, 3,724 European ancestry controls
Serum 25-Hydroxyvitamin D levels
761 Finnish ancestry infants
Coronary artery disease and HDL cholesterol levels (multivariate analysis)
122,733 coronary artery disease cases, 424,528 coronary artery disease controls, 188,577 individuals
Coronary artery disease and LDL cholesterol levels (multivariate analysis)
Coronary artery disease and triglyceride levels (multivariate analysis)
Coronary artery disease and total cholesterol levels (multivariate analysis)
beta-lactam allergy measurement
387 European ancestry cases, 1,224 European ancestry controls
299 European ancestry cases, 362 European ancestry controls
Fasting blood proinsulin levels
up to 8,229 Finnish ancestry non-diabetic individuals
Insulinogenic index
Insulin disposition index
Proinsulin levels (late-phase conversion)
Proinsulin levels (early-phase conversion)
37 Mexican ancestry individuals
Hip shape (DXA scan)
10,217 European ancestry individuals, 5,717 individuals
Birth weight or body mass index (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 339,224 European and unknown ancestry individuals with body mass index measurements
Birth weight or waist-hip ratio (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 224,459 European and unknown ancestry individuals with waist-hip ratio measurements
Birth weight or waist circumference (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 224,459 European and unknown ancestry individuals with waist circumference measurements
Birth weight or type 2 diabetes (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 110,452 European and unknown ancestry individuals with type 2 diabetes data
Birth weight or fasting glucose levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 46,186 European and unknown ancestry individuals with fasting glucose measurements
Birth weight or fasting insulin levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 46,186 European and unknown ancestry individuals with fasting insulin measurements
Birth weight or hemoglobin A1C levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 46,368 European and unknown ancestry individuals with hemoglobin A1C measurements
Birth weight or insulin secretion (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 5,318 European and unknown ancestry individuals with insulin secretion measurements
Birth weight or insulin sensitivity index (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 16,753 European and unknown ancestry individuals with insulin sensitivity measurements
Birth weight or coronary artery disease (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 184,305 European and unknown ancestry individuals with coronary artery disease data
Birth weight or myocardial infarction (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 129,000 European and unknown ancestry individuals with myocardial infarction data
Birth weight or LDL cholesterol levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 188,577 European and unknown ancestry individuals with LDL cholesterol measurements
Birth weight or HDL cholesterol levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 188,577 European and unknown ancestry individuals with HDL cholesterol measurements
Birth weight or total cholesterol levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 188,577 European and unknown ancestry individuals with total cholesterol measurements
Birth weight or triglycerides levels (pleiotropy)
153,781 European and unknown ancestry individuals with birth weight measurements, 188,577 European and unknown ancestry individuals with triglycerides measurements
Sodium levels in epilepsy
1,252 European ancestry cases
Carbamazepine- or oxcarbazepine-induced hyponatremia in epilepsy
448 European ancestry cases, 804 European ancestry controls
Severe carbamazepine- or oxcarbazepine-induced hyponatremia in epilepsy
61 European ancestry cases, at least 804 European ancestry controls
Carbamazepine-induced hyponatremia in epilepsy
331 European ancestry cases, 700 European ancestry controls
Oxcarbazepine-induced hyponatremia in epilepsy
170 European ancestry cases, 127 European ancestry controls
Carbamazepine metabolism (carbamazepine-10,11-diol to carbamazepine ratio) in epilepsy
468 European ancestry cases
Glycosuria in pregnancy (maternal genotype effect)
1,249 European ancestry cases, 5,140 European ancestry controls
Glycosuria in pregnancy (offspring genotype effect)
747 European ancestry cases, 2,991 European ancestry controls
Glycosuria in pregnancy (maternal and offspring genotype effect)
1,996 European ancestry cases, 8,131 European ancestry controls
Malaria
7,957 African ancestry cases, 7,746 African ancestry controls, 718 Asian ancestry cases, 546 Asian ancestry controls, 402 Oceanian cases, 374 Oceanian controls
Anti-sp100 seropositivity in primary biliary cholangitis
211 Han Chinese ancestry cases, 711 Han Chinese ancestry controls
234 Han Chinese ancestry cases, 1,018 Han Chinese ancestry controls
Anti-gp210 seropositivity in primary biliary cholangitis
350 Han Chinese ancestry cases, 562 Han Chinese ancestry controls
444 Han Chinese ancestry cases, 808 Han Chinese ancestry controls
Pulse rate
733 Ashkenazi Jewish ancestry individuals (founder/population isolate), 168 Sephardi Jewish, North African Jewish, Middle Eastern, Caucasian and Yemenite Jewish individuals
1,620 individuals
Weight
Waist circumference
1620 individuals
Hip circumference
Chemerin levels
2,197 Taiwanese individuals
Metabolic coherence (transcriptomic)
369 European ancestry individuals
3,783 European ancestry individuals
17,881 European ancestry cases, 410,350 European ancestry controls
Testicular cancer
713 European ancestry cases, 359,825 European ancestry controls
Oral cavity and pharyngeal cancer
1,223 European ancestry cases, 410,350 European ancestry controls
Esophageal or stomach cancer
1,091 European ancestry cases, 410,350 European ancestry controls
10,792 European ancestry cases, 410,350 European ancestry controls
Melanoma
6,777 European ancestry cases, 410,350 European ancestry controls
Rectal cancer
2,091 European ancestry cases, 410,350 European ancestry controls
Colon cancer
3,793 European ancestry cases, 410,350 European ancestry controls
2,485 European ancestry cases, 410,350 European ancestry controls
Thyroid cancer
762 European ancestry cases, 410,350 European ancestry controls
Lymphocytic leukemia
852 European ancestry cases, 410,350 European ancestry controls
663 European ancestry cases, 410,350 European ancestry controls
6,563 European ancestry cases, 410,350 European ancestry controls
Bladder cancer
2,242 European ancestry cases, 410,350 European ancestry controls
Kidney cancer
1,338 European ancestry cases, 410,350 European ancestry controls
Non-Hodgkin's lymphoma
2,400 European ancestry cases, 410,350 European ancestry controls
2,037 European ancestry cases, 410,350 European ancestry controls
1,259 European ancestry cases, 410,350 European ancestry controls
Cancer (pleiotropy)
64,962 European ancestry cases, 410,350 European ancestry controls
Cancer (pleiotropy)(bidirectional)
76,081 European ancestry individuals, 127,395 Japanese ancestry individuals
Gamma glutamyl transferase levels
Microscopic colitis in proton-pump inhibitor treatment
up to 98 European ancestry cases, up to 46,397 European ancestry controls
Microscopic colitis
423 European ancestry cases, 445,232 European ancestry controls
17,286 African American individuals, 22,192 Hispanic/Latino individuals, 4,680 Asian ancestry individuals, 3,939 Native Hawaiian ancestry individuals, 647 Native American ancestry individuals, 1,052 individuals
303,288 European ancestry individuals
253,288 European ancestry individuals, 17,286 African American individuals, 22,192 Hispanic/Latino individuals, 4,680 Asian ancestry individuals, 3,939 Native Hawaiian ancestry individuals, 647 Native American ancestry individuals, 1,052 individuals
QRS duration
3,274 African American individuals, 13,420 Hispanic/Latino individuals, 126 Asian ancestry individuals, 226 Native American ancestry individuals
8,349 African American individuals, 15,912 Hispanic/Latino individuals, 1,811 Asian ancestry individuals, 1,777 Native Hawaiian ancestry individuals, 574 Native American ancestry individuals, 97 individuals
Addison's disease
1,223 European ancestry cases, 4,097 European ancestry controls
Emotional lability
3,268 European ancestry individuals
Lack of behavioral control
Type A behavior
Locus of control over disease
Psychoticism
Serum galactose-deficient IgA1 levels in IgA nephropathy
849 Han Chinese ancestry individuals
313 Han Chinese ancestry individuals
Nosetip height
424 Uyghur ancestry female individuals, 270 Uyghur ancestry male individuals
108 Uyghur ancestry female individuals, 63 Uyghur ancestry male individuals, 1,080 Han Chinese ancestry female individuals, 424 Han Chinese ancestry male individuals
Nasal root breadth
Nasal root height
Eye length
Interorbital distance
Labial fissure length
Lip thickness
Lower face length
Brow ridge morphology (principal component model)
Eye morphology (principal component model)
Side of face morphology (principal component model)
Cheek morphology (principal component model)
Nose morphology (principal component model)
Mouth morphology (principal component model)
Brow ridge morphology (partial least square model)
Eye morphology (partial least square model)
Side of face morphology (partial least square model)
Cheek morphology (partial least square model)
Nose morphology (partial least square model)
Mouth morphology (partial least square model)
Nose wing breadth
Nose length
Hodgkin's lymphoma
5,325 European ancestry cases, 22,425 European ancestry controls
IgA levels
16,883 Icelandic ancestry individuals
2,151 Swedish ancestry individuals
Composite immunoglobulin trait (IgA x IgG x IgM)
14,183 Icelandic ancestry individuals
2,146 Swedish ancestry individuals
Composite immunoglobulin trait (IgA x IgG/IgM)
Composite immunoglobulin trait (IgA x IgG)
Composite immunoglobulin trait (IgA/IgG)
Composite immunoglobulin trait (IgA/IgM)
Composite immunoglobulin trait (IgG/IgM)
IgM levels
14,442 Icelandic ancestry individuals
2,157 Swedish ancestry individuals
IgG levels
15,536 Icelandic ancestry individuals
2,158 Swedish ancestry individuals
Urinary albumin-to-creatinine ratio
437,027 European ancestry individuals
60,130 individuals
Keratoconus
522 European ancestry cases, 655 European ancestry controls
818 European ancestry cases, 3,858 European ancestry controls
Hypospadias (moderate to severe)
197 Han Chinese ancestry cases, 933 Han Chinese ancestry controls
255 Han Chinese ancestry cases, 573 Han Chinese ancestry controls
Sphingolipid d18:1/d18:2 ratio
658 European ancestry individuals
Bronchodilator response x age interaction in asthma
892 European ancestry individuals
559 European ancestry individuals
964 European ancestry cases, 899 European ancestry controls
BRCA1 mutation in breast cancer
7,257 European ancestry cases, 60,212 European ancestry controls
BRCA2 mutation in breast cancer
5,097 European ancestry cases, 57,725 European ancestry controls
BRCA1 mutation in healthy women
5,750 European ancestry cases, 45,881 European ancestry controls
BRCA2 mutation in healthy women
4,456 European ancestry cases, 43,549 European ancestry controls
Academic attainment (English)
5,983 European ancestry adolescents
Academic attainment (maths)
6,017 European ancestry adolescents
Academic attainment (science)
6,089 European ancestry adolescents
Alzheimer's disease or cardiovascular risk factors (pleiotropy)
17,008 European ancestry Alzheimer's disease cases, 48,286 European ancestry type 2 diabetes cases, 17,283 European ancestry coronary artery disease cases, 425,739 European ancestry controls, 923,864 European ancestry individuals
148,726 European ancestry cases, 24,646 African American cases, 8,616 Hispanic cases, 46,511 Asian ancestry cases, 965,732 European ancestry controls, 31,446 African American controls, 11,829 Hispanic controls, 169,776 Asian ancestry controls
Affymetrix, Illumina [at least 945603] (imputed)
24,646 African American cases, 31,446 African American controls
148,726 European ancestry cases, 965,732 European ancestry controls
Affymetrix, Illumina [1198787] (imputed)
8,616 Hispanic cases, 11,829 Hispanic controls
Affymetrix, Illumina [1077427] (imputed)
46,511 Asian ancestry cases, 169,776 Asian ancestry controls
Chronic kidney disease x type 2 diabetes interaction
67,403 European ancestry cases, 129,827 European ancestry controls
Peripheral arterial disease x type 2 diabetes interaction
5,882 European ancestry cases, 161,348 European ancestry controls
Coronary heart disease x type 2 diabetes interaction
56,285 European ancestry coronary heart disease cases, 140,945 European ancestry controls
Acute ischemic stroke x type 2 diabetes interaction
11,796 European ancestry cases, 178,481 European ancestry controls
Retinopathy x type 2 diabetes interaction
13,881 European ancestry cases, 123,538 European ancestry controls
Neuropathy x type 2 diabetes interaction
40,475 European ancestry cases, 110,331 European ancestry controls
Urinary albumin excretion (no hypertensive medication)
302,687 European ancestry individuals without hypertensive medication
Urinary albumin excretion
382,500 European ancestry individuals
Digit length ratio (right hand)
12,636 European ancestry individuals
Digit length ratio
12,586 European ancestry individuals
Digit length ratio (left hand)
14,382 European ancestry individuals, 1,279 non-European ancestry individuals
821 individuals
HDL cholesterol
HDL cholesterol and triglyceride levels (pleiotropy)
817 individuals
Response to fenofibrate (HDL cholesterol levels)
Response to fenofibrate (triglyceride levels)
774 individuals
Delayed reward discounting
986 European ancestry individuals
Hand grip strength
334,825 British ancestry individuals
223,215 British ancestry individuals
111,610 British ancestry individuals
Seasonality in depression
1,380 European ancestry cases, 2,464 European ancestry controls
Affymetrix, Illumina [8153767] (imputed)
Seasonality and depression
1,380 European ancestry cases, 2,937 European ancestry controls
Hypersomnia (HLA-DQB1*06:02 negative)
119 Japanese ancestry cases, 1,582 Japanese ancestry controls
283 Japanese ancestry cases, 433 Japanese ancestry controls
Low density lipoprotein triglyceride levels
2,900 German ancestry individuals
764 Middle Eastern ancestry cases, 1,343 Middle Eastern ancestry controls
Eyebrow thickness
2,961 Han Chinese ancestry individuals, 721 Uyghur ancestry individuals, 2,301 Latin American ancestry individuals
4,411 Dutch ancestry individuals
Facial pigmentation measurement (UV light)
11,079 Korean women
5,940 Korean women
Facial pigmentation measurement (polar light)
Emotional support seeking
6,403 Japanese ancestry individuals
7,685 Japanese ancestry individuals
Positive reappraisal
Problem solving
Disengagement
Emotional coping (emotional expression/emotional support seeking)
Approach coping (positive reappraisal/problem solving)
Perceived stress
Emotional expression
Carotid intima media thickness in rheumatoid arthritis
1,355 Spanish ancestry individuals
Cardiovascular event in rheumatoid arthritis
467 Spanish ancestry patients, 2,522 Spanish ancestry controls
Ischemic heart disease in rheumatoid arthritis
224 Spanish ancestry patients, 2,765 Spanish ancestry controls
Carotid plaques in rheumatoid arthritis
Cotinine levels in smokers with chronic obstructive pulmonary disease
4,024 European ancestry individuals
Current cigarettes per day in chronic obstructive pulmonary disease
2,854 European ancestry individuals
Smoking cessation in chronic obstructive pulmonary disease
717 European ancestry sustained quitter cases, 2,175 European ancestry continuous smoker cases
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease
2,706 European ancestry individuals
Triglyceride levels (parental genotype effect)
173 European ancestry families
Triglyceride levels in response to fenofibrate treatment (parental genotype effect)
Triglyceride change in response to fenofibrate (parental genotype effect)
Triglyceride levels in response to fenofibrate
Triglyceride change in response to fenofibrate treatment
Lateral ventricular volume in normal aging
22,045 European ancestry individuals, 1,488 African American individuals
Latent autoimmune diabetes
2,634 European ancestry cases, 5,947 European ancestry controls
345 European ancestry cases, 1,664 European ancestry controls
Affymetrix, Illumina [7868002] (imputed)
Latent autoimmune diabetes vs. type 2 diabetes
2,779 European ancestry latent autoimmune diabetes cases, 10,396 European ancestry type 2 diabetes cases
Affymetrix, Illumina [8328843] (imputed)
Latent autoimmune diabetes vs. type 1 diabetes
2,454 European ancestry latent autoimmune diabetes cases, 968 European ancestry type 1 diabetes cases
Affymetrix, Illumina [8465706] (imputed)
29,531 European ancestry cases, 128,494 European ancestry controls
50,915 British ancestry cases, 232,837 British ancestry controls
Affymetrix, Illumina [up to 9775703] (imputed)
Lung function (FEV1)
60,552 European ancestry individuals, 8,429 African individuals, 9,959 Korean ancestry individuals, 11,775 Hispanic individuals
Affymetrix, Illumina [10900000] (imputed)
Paediatric migraine
380 African American cases, 2,129 African American controls, 599 European American cases, 7,327 European American controls
233 African American cases, 4,038 African American controls
Coronary artery aneurysm in Kawasaki disease
33 cases, 215 controls
12 cases, 532 controls
Diastolic blood pressure x alcohol consumption interaction (1df test)
1,764 Han Chinese and unknown ancestry alcohol drinkers, 14,779 Han Chinese and unknown ancestry non-drinkers
Systolic blood pressure x alcohol consumption interaction (1df test)
10,070 European ancestry individuals, 1,623 Han Chinese ancestry individuals, 843 African American individuals, 445 Hispanic individuals
Affymetrix, Illumina [2374420] (imputed)
Body fat mass
Hip bone mineral density and total body fat mass (bivariate analysis)
Falling risk
89,076 European ancestry cases, 362,103 European ancestry controls
2,215 cases, 6289 controls
Postburn scar height
665 European ancestry individuals
Postburn scar pliability
Maternal chorioamnionitis
213 preterm birth infant cases, 707 preterm birth infant controls
Metabolic syndrome (multivariate analysis)
1,946 Korean ancestry cases, 6,427 Korean ancestry controls
430 Korean ancestry cases, 3,264 Korean ancestry controls
31,964 European ancestry cases, 419,135 European ancestry controls
4,611 European ancestry cases, 31,478 European ancestry controls
Response to hepatitis B vaccine
107 Japanese ancestry low responder individuals, 351 Japanese ancestry intermediate responder individuals, 735 Japanese ancestry high responder individuals
Change in HbA1c levels in response to metformin treatment in type 2 diabetes
845 European ancestry individuals, 222 African American individuals, 245 individuals
6,963 European ancestry individuals, 1,015 African American individuals, 4,520 individuals
Affymetrix, Illumina [26000000] (imputed)
Acute lymphoblastic leukemia in childhood (B cell precursor)
2,442 European ancestry cases, 14,609 European ancestry controls
Plasma renin activity levels
461 European ancestry individuals, 297 African American ancestry individuals
150 European ancestry individuals
Immunoglobulin M against phosphorylcholine (IgM anti-PC) levels
3,002 European ancestry individuals
646 European ancestry individuals
1,353 Kuwaiti ancestry individuals
1,176 Kuwaiti ancestry individuals
Facial wrinkles
3,513 north-western European ancestry individuals
599 north-western European ancestry individuals
Delirium
421 European ancestry cases, 5,614 European ancestry controls
Affective disorder and suicide attempts
4,302 European ancestry cases, 13,294 European ancestry population controls
6,024 European ancestry cases, 44,240 European ancestry controls
48,286 European ancestry cases, 250,671 European ancestry controls, 33,126 African American, East Asian, Hispanic/Latino or South Asian cases, 120,161 African American, East Asian, Hispanic/Latino or South Asian controls
up to 48,286 European ancestry cases, up to 250,671 European ancestry controls
Type 2 diabetes (adjusted for BMI)
46,802 European ancestry cases, 347,481 European ancestry controls
23,948 European and unknown ancestry cases, 118,538 European and unknown ancestry controls
9,676 European ancestry cases, 347,481 European ancestry controls
Asthma (adult onset)
22,296 European ancestry cases, 347,481 European ancestry controls
Asthma and attention deficit hyperactivity disorder
46,802 European ancestry asthma cases, 19,099 European ancestry attention deficit hyperactivity disorder cases, 381,675 European ancestry controls
Asthma and anxiety disorder
46,802 European ancestry asthma cases, 5,710 European ancestry anxiety disorder cases, 359,081 European ancestry controls
Asthma and major depressive disorder
46,802 European ancestry asthma cases, 59,851 European ancestry major depressive disorder cases, 460,635 European ancestry controls
Gestational age at birth (child effect)
666 Finnish ancestry infants
Spontaneous preterm birth (preterm birth)
247 Finnish ancestry infant cases, 419 Finnish ancestry infant controls
Early spontaneous preterm birth
172 Finnish ancestry infant cases, 419 Finnish ancestry infant controls
Moderate-to-late spontaneous preterm birth
75 Finnish ancestry infant cases, 419 Finnish ancestry infant controls
Spontaneous preterm birth with premature rupture of membranes
133 Finnish ancestry infant cases, 419 Finnish ancestry infant controls
Spontaneous preterm birth without premature rupture of membranes
101 Finnish ancestry infant cases, 419 Finnish ancestry infant controls
Mosaic loss of chromosome Y (Y chromosome dosage)
95,380 Japanese men
205,011 men
Gout vs. Hyperuricemia
945 Japanese ancestry cases, 1,003 Japanese ancestry controls
1,915 Japanese ancestry cases, 2,146 Japanese ancestry controls
Erectile dysfunction
6,175 European ancestry male cases, 217,630 European ancestry male controls
Affymetrix, Illumina [at least 807411] (imputed)
456,426 European ancestry individuals, 224,849 individuals
456,426 European ancestry individuals, 237,103 individuals
Red vs. brown/black hair color
15,731 British ancestry red hair individuals, 283,920 British ancestry brown or black hair individuals
Blond vs. brown/black hair color
39,397 British ancestry blond hair individuals, 283,920 British ancestry brown or black hair individuals
Brown vs. black hair color
269,394 British ancestry brown hair individuals, 14,526 British ancestry black hair individuals
84 South East Asian ancestry cases, 89 South East Asian ancestry controls
Lifetime smoking index
462,690 European ancestry individuals
Machado-Joseph disease (age at onset)
700 cases
Number of decayed, missing and filled tooth surfaces or use of dentures
14,976 European ancestry individuals with decayed, missing or filled tooth surface measurement, 11,816 Hispanic/Latino individuals with decayed, missing or filled tooth surface measurement, 77,714 European ancestry dentures cases, 383,317 European ancestry controls
Affymetrix, Illumina [~ 8900000] (imputed)
Number of decayed, missing and filled tooth surfaces
14,976 European ancestry individuals, 11,816 Hispanic/Latino individuals
Affymetrix, Illumina [at least 8900000] (imputed)
Number of decayed and filled tooth surfaces per available tooth surface
14,717 European ancestry individuals, 11,816 Hispanic/Latino individuals
Periodontitis
17,353 European and Hispanic/Latino ancestry cases, 28,210 European and Hispanic/Latino ancestry controls, 1,680 Japanese ancestry cases, 15,670 Japanese ancestry controls
Bleeding gums
60,210 European ancestry cases, 400,821 European ancestry controls
Painful gums
13,311 European ancestry cases, 447,720 European ancestry controls
Dentures
77,714 European ancestry cases, 383,317 European ancestry controls
Toothache
18,959 European ancestry cases, 442,072 European ancestry controls
47,091 European ancestry cases, 413,940 European ancestry controls
Number of natural teeth
16,133 European ancestry individuals, 11,816 hispanic/Latino individuals
Loose teeth
18,979 European ancestry cases, 442,052 European ancestry controls
Periodontitis or loose teeth
17,353 European and Hispanic/Latino ancestry periodontitis cases, 18,979 European ancestry loose teeth cases, 470,262 European and Hispanic/latino ancestry controls
Antipsychotic drug-induced weight gain in schizophrenia
144 European ancestry individuals, 57 African American individuals
Antipsychotic drug-induced weight gain in schizophrenia or autism
269 European ancestry individuals
Alcohol dependence or heroin dependence or methamphetamine dependence
521 Han Chinese ancestry alcohol dependence cases, 1,026 Han Chinese ancestry heroin dependence cases, 1,749 Han Chinese ancestry methamphetamine dependence cases, 2,859 Han Chinese ancestry controls
146 Han Chinese ancestry alcohol dependence cases, 1,045 Han Chinese ancestry heroin dependence cases, 763 Han Chinese ancestry methamphetamine dependence cases, 1,904 Han Chinese ancestry controls
Phenylephrine infusion rate during anesthesia
1,534 European ancestry individuals
up to 237,050 European ancestry individuals, up to 16,935 African ancestry individuals, up to 30,468 South Asian ancestry individuals, up to 8,287 East Asian ancestry individuals, 5,084 Hispanic individuals
up to 286,268 European and unknown ancestry individuals
up to 237,050 European ancestry individuals
Pancreatic ductal adenocarcinoma
9,040 European ancestry cases, 12,496 European ancestry controls
Left planum temporale grey matter volume
18,037 British ancestry individuals
Right planum temporale grey matter volume
18,039 British ancestry individuals
Planum temporale asymmetry index
18,049 British ancestry individuals
Cognitive performance (language ability)
488 European ancestry single-episode cases, 533 European ancestry recurrent episode cases, 5,991 European ancestry controls
Cognitive performance (processing speed) x major depressive disorder status interaction
533 European ancestry recurrent episode cases, 5,991 European ancestry controls
Cognitive performance (language ability) x major depressive disorder status interaction
Cognitive performance (processing speed) x major depressive disorder type interaction
488 European ancestry single-episode cases, 533 European ancestry recurrent episode cases
Cognitive performance (processing speed) in major depressive disorder
Cognitive performance (processing speed)
Response to beta blocker use in hypertension (systolic blood pressure)
1,254 European ancestry individuals
1,552 European ancestry individuals, 315 African American individuals
Affymetrix, Illumina [6596214] (imputed)
Response to beta blocker use in hypertension (diastolic blood pressure)
Knee pain
22,204 British ancestry cases, 149,312 British ancestry controls
Proliferative diabetic retinopathy
64 African ancestry cases, 227 African ancestry controls
19 African American cases, 50 African American controls
Affymetrix, Illumina [18433741] (imputed)
Hypotension and cognitive impairment
56 Han Chinese ancestry cases, 1,799 Han Chinese ancestry controls
Response to allopurinol in gout (change in serum uric acid levels)
2,647 European ancestry cases, 303 East Asian cases, 115 African American cases, 114 Latino cases
355 European ancestry cases
318 European ancestry cases, 502 European ancestry cases
T wave morphology restitution during exercise (MTAG)
51,574 European ancestry individuals
T wave morphology restitution during exercise
T wave morphology restitution during recovery from exercise
T wave morphology restitution during recovery from exercise (MTAG)
Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease
up to 1,209 European ancestry individuals, up to 136 African, African American, South East Asian, East Asian, American Indian/Alaskan Native, Mixed race, Arabic/North African, Central/South Asian or Japanese Asian ancestry individuals
Response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease
530 European, African, African American, South East Asian, East Asian, American Indian/Alaskan Native, Mixed race, Arabic/North African, Central/South Asian or Japanese Asian ancestry treated cases, 658 European, African, African American, South East Asian, East Asian, American Indian/Alaskan Native, Mixed race, Arabic/North African, Central/South Asian or Japanese Asian ancestry untreated cases
Change in trough FEV1 in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease
1,869 European ancestry individuals, 55 African American or African ancestry individuals, 33 South East Asian ancestry individuals, 33 East Asian ancestry individuals, 7 American Indian/Alaskan Native ancestry individuals, 4 Mixed race individuals, 3 Arabic/North African ancestry individuals, 1 Central/South Asian ancestry individuals
Plasma anti-thyroid peroxidase levels
1,593 Croatian ancestry women, 1,025 Croatian ancestry men
Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis)
up to 1,596 Croatian ancestry women, up to 1,033 Croatian ancestry men
Plasma anti-thyroglobulin levels
1,596 Croatian ancestry women, 1,033 Croatian ancestry men
815 African ancestry early adolescents
Response to ketamine in bipolar disorder or major depression (antidepressant effects)
157 European ancestry individuals
Response to ketamine in bipolar disorder or major depression (dissociation effects)
90 European ancestry individuals
Pulmonary arterial hypertension
2,085 European ancestry cases, 9,659 European ancestry controls
755 African ancestry cases, 1,235 African ancestry controls
High-grade serous ovarian cancer
537 African ancestry cases, 1,235 African ancestry controls
Hepatitis C (spontaneous viral clearance)
701 European ancestry cases, 1,035 European ancestry controls, 445 African American cases, 1,756 African American controls, 173 Hispanic ancestry cases, 313 Hispanic ancestry controls
445 African American cases, 1,756 African American controls
701 European ancestry cases, 1,035 European ancestry controls
173 Hispanic ancestry cases, 313 Hispanic ancestry controls
Waist-to-hip ratio adjusted for BMI
379,501 European ancestry female individuals
315,284 European ancestry male individuals
697,734 European ancestry individuals
381,152 European female individuals
316,772 European ancestry male individuals
806,834 European ancestry individuals
434,794 European ancestry female individuals
374,756 European ancestry male individuals
694,649 European ancestry individuals
7,721 European ancestry individuals
1,788 European ancestry individuals
35,006 Danish ancestry cases, 16,366 Danish ancestry controls
Psychiatric disorder without cannabis use disorder
32,716 Danish ancestry cases, 16,269 Danish ancestry controls
Cannabis use disorder vs schizophrenia
2,387 Danish ancestry cannabis use disorder cases, 1,789 Danish ancestry schizophrenia cases
Cannabis use disorder
2,387 Danish ancestry cases, 48,985 Danish ancestry controls
5,501 Icelandic ancestry cases, 301,041 Icelandic ancestry controls
Serum platinum levels after completion of cisplatin chemotherapy
866 European ancestry individuals, 17 non-European ancestry individuals, 127 individuals
Response to adalimumab in hidradenitis suppurativa (abscess and inflammatory nodule count increase)
307 European ancestry individuals
Uterine fibroids and heavy menstrual bleeding
3,409 European ancestry cases, 199,171 European ancestry controls
Heavy menstrual bleeding
9,813 European ancestry cases, 210,946 European ancestry controls
20,406 European ancestry cases, 223,918 European ancestry controls
15,068 European ancestry cases, 43,587 European ancestry controls
Affymetrix, Illumina [8662096] (imputed)
4,775 European ancestry cases, 60,148 European ancestry controls
1,139 European ancestry cases, 60,148 European ancestry controls
107 Finnish ancestry infant cases, 865 Finnish ancestry infant controls
Post-term birth
7,888 European ancestry cases, 60,148 European ancestry controls
670 European ancestry infant cases, 5,626 European ancestry infant controls
84,689 European ancestry infants
9,291 European ancestry infants
Subpleural-predominant interstitial lung abnormalities
965 European ancestry cases, 154 African American cases, 168 cases, 7,255 European ancestry controls, 1,717 African American controls, 450 controls
Affymetrix, Illumina [at least 412049] (imputed)
Interstitial lung abnormalities
1,181 European ancestry cases, 280 African American cases, 54 Hispanic cases, 184 cases, 7,255 European ancestry controls, 2,184 African American controls, 385 Hispanic controls, 450 controls
Gamma glutamyl transferase levels in excessive alcohol consumption
951 individuals
Alanine aminotransferase levels in excessive alcohol consumption
Aspartate aminotransferase levels in excessive alcohol consumption
Gamma glutamyl transferase levels in low alcohol consumption
8,716 individuals
Alanine aminotransferase levels in low alcohol consumption
Aspartate aminotransferase levels in low alcohol consumption
Voxel-wise structural brain imaging measurements in Alzheimer’s disease
708 European ancestry individuals
Childhood obesity
8,613 European ancestry cases, 3,213 African American cases, 69 Moroccan ancestry cases, 986 Hispanic/Latino cases, 124 East Asian ancestry cases, 12,696 European ancestry controls, 1,392 African American controls, 64 Moroccan ancestry controls, 993 Hispanic/Latino controls, 454 East Asian ancestry controls
921 European ancestry cases, 392 Southwest American Indian ancestry cases, 575 Hispanic cases, 1,930 European ancestry controls, 2,456 Southwest American Indian ancestry controls, 303 Hispanic controls
Affymetrix, Illumina [up to 15123508] (imputed)
5,088 Japanese ancestry cases, 10,682 Japanese ancestry controls
4,818 Japanese ancestry cases, 73,261 Japanese ancestry controls
Thoracic aortic calcification levels
8,422 European ancestry individuals
Affymetrix, Illumina [9000000] (imputed)
Abdominal aortic calcification levels
9,417 European ancestry individuals
1,595 African American individuals, 496 Hispanic or Latin American individuals
Eosinophilic esophagitis
1,210 European ancestry cases, 3,734 European ancestry controls
Bipolar I disorder
14,879 European ancestry cases, 31,358 European ancestry controls
Bipolar II disorder
3,421 European ancestry cases, 31,358 European ancestry controls
Schizoaffective disorder-bipolar type
977 European ancestry cases, 31,358 European ancestry controls
20,352 European ancestry cases, 31,358 European ancestry controls
9,412 European ancestry cases, 137,760 European ancestry controls
up to 23,508 African ancestry individuals, 4,649 Asian ancestry individuals, up to 77,047 European ancestry individuals, 6,705 Hispanic individuals
Affymetrix, Illumina, Perlegen [NR] (imputed)
HDL cholesterol levels x smoking (current vs non smokers) interaction (1df test)
5,120 African ancestry current smoker individuals, 2,394 Asian ancestry current smoker individuals, 15,129 European ancestry current smoker individuals, 747 Hispanic current smoker individuals, 18,641 African ancestry non smoker individuals, 10,777 Asian ancestry non smoker individuals, 75,138 European ancestry non smoker individuals, 5,873 Hispanic non smoker individuals
1,825 African ancestry current smoker individuals, 16,241 Asian ancestry current smoker individuals, 32,416 European ancestry current smoker individuals, 3,570 Hispanic current smoker individuals, 5,392 African ancestry non smoker individuals, 65,276 Asian ancestry non smoker individuals, 114,795 European ancestry non smoker individuals, 13,952 Hispanic non smoker individuals
Exacerbation frequency in mepolizumab-treated chronic obstructive pulmonary disease
504 European ancestry individuals, 73 Asian ancestry individuals, 18 Native American individuals, 5 African American individuals, 10 individuals
Frequency of exacerbations requiring hospitalisation in mepolizumab-treated chronic obstructive pulmonary disease
Hydrolysed wheat protein allergy
452 Japanese ancestry cases, 2,700 Japaneses ancestry controls
45 Japanese ancestry cases, 326 Japaneses ancestry controls
Change in neurofilament light levels
545 European ancestry individuals
Cytokine levels
9,263 Finnish ancestry individuals
Cytokine network levels (multivariate analysis)
Rate of ventricular enlargement
507 European ancestry individuals
1,239 Japanese ancestry cases, 2,146 Japanese ancestry controls
1,275 Japanese ancestry cases, 1,610 Japanese ancestry controls
Severe gastric atrophy
120 Japanese ancestry cases, 760 Japanese ancestry controls
435 Japanese ancestry cases, 184 Japanese ancestry controls
Pepsinogen-I levels
3,385 Japanese ancestry individuals
2,885 Japanese ancestry individuals
Pepsinogen I/II ratio
Gastric atrophy
479 Japanese ancestry cases, 760 Japanese ancestry controls
1,091 Japanese ancestry cases, 184 Japanese ancestry controls
Loneliness
511,280 European ancestry individuals
Affymetrix, Illumina [up to 14113458] (imputed)
Cancer
7,745 European ancestry male cases, 58,562 European ancestry male controls
67,034 European ancestry men
8,715 European ancestry men, 9,793 men
Metabolite levels
1,954 Chinese ancestry individuals
89,893 European ancestry individuals, 20,989 African American individuals, 12,450 Asian ancestry individuals, 3,994 HIspanic individuals
136,986 European ancestry individuals, 4,475 African American or Afro-Caribbean individuals, 108,431 Asian ancestry individuals, 13,714 Hispanic individuals, 3,652 Brazilian ancestry individuals
LDL cholesterol levels in current drinkers
56,505 European ancestry individuals, 9,870 African American individuals, 2,491 Asian ancestry individuals, 2,528 Hispanic individuals
107,548 European ancestry individuals, 2,028 African American or Afro-Caribbean individuals, 41,240 Asian ancestry individuals, 6,622 Hispanic individuals, 1,984 Brazilian ancestry individuals
HDL cholesterol levels in current drinkers
Triglyceride levels in current drinkers
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)
56,505 European ancestry current drinkers, 9,870 African American current drinkers, 2,491 Asian ancestry current drinkers, 2,528 Hispanic current drinkers, 33,388 European ancestry non-drinkers, 11,119 African American non-drinkers, 9,959 Asian ancestry non-drinkers, 1,466 Hispanic non-drinkers
107,548 European ancestry current drinkers, 2,028 African American or Afro-Caribbean current drinkers, 41,240 Asian ancestry current drinkers, 6,622 Hispanic individuals, 1,984 Brazilian ancestry individuals, 29,438 European ancestry non-drinkers, 2,447 African American or Afro-Caribbean non-drinkers, 67,191 Asian ancestry non-drinkers, 7,092 Hispanic non-drinkers, 1,668 Brazilian ancestry non-drinkers
Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (1df)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (1df)
Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (1df)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)
44,831 European ancestry regular drinkers, 3,976 African American regular drinkers, 1,288 Asian ancestry regular drinkers, 827 Hispanic regular drinkers, 11,674 European ancestry non-regular drinkers, 5,894 African American non-regular drinkers, 1,203 Asian ancestry non-regular drinkers, 1,701 Hispanic non-regular drinkers
71,281 European ancestry regular drinkers, 711 African American or Afro-Caribbean regular drinkers, 35,088 Asian ancestry regular drinkers, 3,742 Hispanic regular drinkers, 36,267 European ancestry non-regular drinkers, 1,317 African American or Afro-Caribbean non-regular drinkers, 6,152 Asian ancestry non-regular drinkers, 2,880 Hispanic non-regular drinkers
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)
Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (1df)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (1df)
Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (1df)
16,274 European ancestry cases, 38,269 European ancestry controls
10,365 European ancestry cases, 16,110 European ancestry controls, cases and controls (see Moffatt et al 2010)
611 African American cases, 1,915 African American controls
1,300 Asian ancestry cases, 4,927 Asian ancestry controls
1,320 Hispanic ancestry cases, 4,007 Hispanic ancestry controls
Heart failure
6,504 European ancestry cases, 387,652 European ancestry controls
4,042 European ancestry cases, 8,777 European ancestry controls
Nonischemic cardiomyopathy
1,816 European ancestry cases, 388,326 European ancestry controls
3,282 European ancestry cases, 13,913 European ancestry controls
4,244 European ancestry cases, 3,106 European ancestry controls
Age-related hearing impairment (high minus low frequency)
9,675 European ancestry individuals
3,319 European ancestry individuals, 6,909 Hispanic individuals, 735 African American individuals
Age-related hearing impairment
Age-related hearing impairment (low/mid frequency)
Age-related hearing impairment (high frequency)
Bilirubin levels
25,406 Korean ancestry individuals
Cerebral cortex AV-45 amyloid PET measurement
155 cognitively normal individuals, 72 significant memory concern individuals, 278 with early mild cognitive impairment individuals, 144 late mild cognitive impairment individuals, 125 Alzheimer's disease cases.
Uveal melanoma
590 European ancestry cases, 5,199 European ancestry controls
Uveal melanoma with any chromosomal aberration
417 European ancestry cases, 5,199 European ancestry controls
Choroidal melanoma
438 European ancestry cases, 5,199 European ancestry controls
Uveal melanoma with chromosome 3 loss
253 European ancestry cases, 5,199 European ancestry controls
Uveal melanoma with epithelioid cells
285 European ancestry cases, 5,199 European ancestry controls
Presence of epithelioid cells in uveal melanoma
285 European ancestry cases, 286 European ancestry controls
Uveal melanoma (TNM stage 1 or 2)
330 European ancestry cases, 5,199 European ancestry controls
Uveal melanoma (TNM stage 3 or 4)
255 European ancestry cases, 5,199 European ancestry controls
Disease severity in uveal melanoma (TNM stage 3 or 4 vs TNM stage 1 or 2)
330 European ancestry stage 3 or 4 cases, 255 European ancestry stage 1 or 2 cases
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)
up to 4,595 European ancestry rheumatoid arthritis cases, up to 3,154 European ancestry systemic lupus erythematosus cases, up to 2,281 European ancestry systemic sclerosis cases, up to 1,674 European ancestry idiopathic inflammatory myopathy cases, 19,704 European ancestry controls
Intraocular pressure
5,571 Chinese ancestry individuals
2,981 Chinese ancestry individuals
Sweet taste perception in obesity with metabolic syndrome
378 individuals
Salty taste perception in obesity with metabolic syndrome
Sour taste perception in obesity with metabolic syndrome
Umami taste perception in obesity with metabolic syndrome
Taste perception (total score including phenylthiocarbamide) in obesity with metabolic syndrome
369 individuals
Taste perception (total score including 6-n-propylthiouracil) in obesity with metabolic syndrome
up to 372 individuals
Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome
368 individuals
Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome
372 individuals
11,103 Hispanic or Latin American ancestry individuals
4,822 European ancestry individuals, 429 African American, Asian, Native Hawaiian/other Pacific Islander, Native American/Alaska native or unknown ancestry individuals
Cocaine use disorder
2,070 African American individuals, 1,570 European ancestry individuals
918 African American individuals, 1,382 European ancestry individuals
Cocaine use disorder x non-traditional parental care interaction
Cocaine use disorder x change in residence interaction
Cocaine use disorder x traumatic experience interaction
Cocaine use disorder x household drinking and illicit drug use interaction
Cocaine use disorder x household tobacco use interaction
Epigenetic age acceleration in alcohol use disorder
154 European ancestry individuals, 156 African American individuals
Infection persistence (>18 months) in genital human papillomavirus 16 infection
21 European ancestry male cases, 15 Brazilian ancestry male cases, 4 African-American male cases, 62 European ancestry male controls, 69 Brazilian ancestry male controls, 20 African-American male controls
14,534 European ancestry cases, 531 Han Chinese ancestry cases, 147 African American cases, 24,218 European ancestry controls, 2,875 Han Chinese ancestry controls, 2,584 African American controls
Affymetrix, Illumina [~ 5000000] (imputed)
Childhood absence epilepsy
778 European ancestry cases, 24,218 European ancestry controls
Juvenile absence epilepsy
415 European ancestry cases, 24,218 European ancestry controls
Juvenile myoclonic epilepsy
1,177 European ancestry cases, 4,218 European ancestry controls
Epilepsy (generalized, with tonic-clonic seizures alone)
225 European ancestry cases, 24,218 European ancestry controls
Focal epilepsy (lesion negative)
2,660 European ancestry cases, 24,218 European ancestry controls
Focal epilepsy (with hippocampal sclerosis)
709 European ancestry cases, 24,218 European ancestry controls
Focal epilepsy (with lesion other than hippocampal sclerosis)
2,751 European ancestry cases, 24,218 European ancestry controls
Focal epilepsy
9,095 European ancestry cases, 490 Han Chinese ancestry cases, 86 African American cases, 24,218 European ancestry controls, 2,875 Han Chinese ancestry controls, 2,584 African American controls
Generalized epilepsy
3,708 European ancestry cases, 61 African American cases, 24,218 European ancestry controls, 2,584 African American controls
Age-related cognitive decline (global cognition) (slope of z-scores)
1,145 European ancestry individuals
Age-related cognitive decline (executive function) (slope of z-scores)
Age-related cognitive decline (language) (slope of z-scores)
Age-related cognitive decline (memory) (slope of z-scores)
Age-related cognitive decline (visuospatial skill) (slope of z-scores)
Age-related cognitive decline (attention/processing speed) (slope of z-scores)
Alloimmunization response to red blood cell transfusion in sickle cell anemia
144 African American cases, 123 African American controls
62 African American cases, 68 African American controls
Acne (severe)
5,602 European ancestry cases, 21,120 European ancestry controls
B6 vitamer levels (multivariate analysis)
493 European ancestry individuals
Cerebrospinal fluid pyridoxal phosphate levels
493 Dutch ancestry individuals
Plasma pyridoxal phosphate levels
Cerebrospinal fluid pyridoxal phosphate to pyridoxal ratio
Plasma pyridoxic acid to pyridoxal phosphate ratio
3-month functional outcome in ischaemic stroke (modified Rankin score)
1,225 European ancestry individuals
1,791 European ancestry individuals
Factor VIII levels
25,897 European ancestry individuals, 4,500 African American individuals, 773 Asian ancestry individuals, 1,440 Hispanic individuals
Affymetrix, Illumina [13887196] (imputed)
vWF levels
42,379 European ancestry individuals, 3,700 African American individuals, 275 Hispanic individuals
Affymetrix, Illumina [10537485] (imputed)
vWF and FVIII levels
Up to 42,379 European ancestry individuals, up to 4,500 African American individuals, up to 773 Asian ancestry individuals, up to 1,440 Hispanic individuals
Affymetrix, Illumina [up to 13887196] (imputed)
24,009 European ancestry cases, 150,983 European ancestry controls, 5,373 African ancestry cases, 42,485 African ancestry controls, 1,925 Hispanic cases, 18,285 Hispanic controls
5,117 European ancestry cases, 389,291 European ancestry controls
Affymetrix [at least 20323458] (imputed)
Minimum ankle–brachial index
13,382 European ancestry individuals, 3,284 African ancestry individuals, 998 Hispanic individuals
705 Korean ancestry cases, 1,178 Korean ancestry controls
980 Korean ancestry cases, 2,694 Korean ancestry controls
Fagerstrӧm test for nicotine dependence
19,431 European ancestry individuals
7,010 European ancestry individuals
Time to smoke first cigarette in the morning
18,567 European ancestry individuals
10,061 European ancestry individuals
6,645 individuals
2,384 European ancestry individuals
Cerebral microbleed progression
57 European ancestry cases, 95 European ancestry controls
Cerebral microbleeds
176 European ancestry cases, 278 European ancestry controls
Latent naming speed
441 African American children
883 Hispanic American children
Rapid automised naming and rapid alternating stimulus test performance
883 Hispanic American children, 441 African American children
Rapid automised naming of objects
Rapid alternating stimulus test for letters/numbers
Eosinophilic granulomatosis with polyangiitis (MPO-ANCA positive)
159 European ancestry cases, 6,688 European ancestry controls
43 European and unknown ancestry cases, 121 European and unknown ancestry controls
Eosinophilic granulomatosis with polyangiitis (ANCA negative)
352 European ancestry cases, 6,688 European ancestry controls
94 European and unknown ancestry cases, 121 European and unknown ancestry controls
Eosinophilic granulomatosis with polyangiitis
534 European ancestry cases, 6,688 European ancestry controls
142 European and unknown ancestry cases, 121 European and unknown ancestry controls
Neuritic plaque
909 European ancestry individuals
Neurofibrillary tangles
Diffuse plaques
Cerebral amyloid angiopathy
404 European ancestry mild cases, 209 European ancestry moderate cases, 113 European ancestry severe cases, 183 European ancestry controls
Microscopic brain infarct
253 European ancestry cases, 656 European ancestry controls
Macroscopic brain infarct
327 European ancestry cases, 582 European ancestry controls
Dementia with Lewy bodies
195 European ancestry cases, 714 European ancestry controls
Neuropathologic traits (pleiotropy)
Leisure sedentary behaviour (television watching)
408,815 European ancestry individuals
Leisure sedentary behaviour (computer use)
Driving (hours per day)
Youthful appearance (self-reported)
423,992 European ancestry individuals
Breslow thickness in cutaneous melanoma
8,505 European ancestry individuals
Nicotine metabolite ratio in current smokers
5,185 European ancestry individuals
Cotinine and 3'-hydroxycotinine levels in current smokers
Cotinine levels in current smokers
5,185 European ancestry individuals, 3,700 individuals
4,772 European ancestry individuals
Smoking behaviour (cigarette pack-years)
4,676 European ancestry individuals
Smoking intensity (cotinine levels/cigarettes per day)
Nasopharyngeal carcinoma
1,615 East Asian ancestry cases and 1,025 East Asian ancestry controls
543 East Asian ancestry cases, 735 East Asian ancestry controls
Plasma free amino acid levels (adjusted for twenty other PFAAs)
1,338 Japanese ancestry individuals
Plasma free amino acid levels (adjusted for one other PFAA)
Plasma free proline levels
665 Japanese ancestry individuals
Plasma free asparagine levels
Plasma free amino acid levels
Response to (pegylated) interferon in HBeAg-negative hepatitis B
161 Asian, European, African and other ancestry cases, 253 Asian, European, African and other ancestry controls
Response to (pegylated) interferon in HBeAG-positive hepatitis B
121 Asian, European, African and other ancestry cases, 388 Asian, European, African and other ancestry controls
Response to (pegylated) interferon in chronic hepatitis B
282 Asian, European, African and other ancestry cases, 641 Asian, European, African and other ancestry controls
Schizophrenia
429 European ancestry cases, 255 European ancestry controls
Nonunion in individuals with fractures
131 Northern European ancestry cases, 1,629 Northern European ancestry controls
Hallucinations in long-term cannabis use
91 European ancestry cases, 220 African American cases, 1,826 European ancestry controls, 2,148 African American controls
256 European ancestry cases, 142 African American cases, 2,118 European ancestry controls, 1,114 African American controls
Intracranial aneurysm
173 French Canadian cases, 1,772 French Canadian controls
2,617 cases, 1,416 controls
Skin pigmentation
6,236 Latin American individuals
Eye color (saturation)
Eye color
Hair color
Eye color (brightness)
Eye color (hue)
Skin, hair and eye pigmentation (multivariate analysis)
Parkinson's disease in GBA mutation carriers
1,588 European ancestry cases, 7,584 European ancestry controls
up to 1,194 European ancestry cases, up to 13,901 European ancestry controls
Parkinson's disease in GBA mutation carriers (age at onset)
1,353 European ancestry cases
Non-del(5q) myelodysplastic syndromes
907 European ancestry cases, 5,605 European ancestry controls
6,669 Japanese ancestry cases, 21,930 Japanese ancestry controls
981 Japanese ancestry cases, 1,394 Japanese ancestry controls
Uric acid elevation in response to thiazide-like diuretic in hypertension
73 Japanese ancestry responders, 53 Japanese ancestry non-responders
Hemoglobin levels
684,122 European ancestry individuals
Affymetrix, Illumina [43000000] (imputed)
1,088 British ancestry cases, 407,873 British ancestry controls
875 European ancestry cases, 30,346 European ancestry controls
Central retinal vein equivalent
14,740 European ancestry individuals, 5,113 Asian ancestry individuals, 3,345 African American individuals, 1,077 Hispanic individuals
5,472 European ancestry individuals
Central retinal arteriolar equivalent
White matter hyperintensities
39,011 European ancestry individuals, 2,099 African ancestry individuals, 795 Hispanic individuals, 3,299 Asian ancestry individuals
White matter integrity (fractional anisotropy)
17,663 European ancestry individuals
White matter integrity (mean diffusivity)
17,467 European ancestry individuals
Testosterone levels x fluid intelligence interaction
160,121 British ancestry individuals
Testosterone levels x alcohol consumption (drinks per week) interaction
388,571 British ancestry individuals
Testosterone levels x smoking behaviour (cigarettes smoked per day) interaction
414,294 British ancestry individuals
Bioavailable testosterone levels x smoking behaviour (cigarettes smoked per day) interaction
Bioavailable testosterone levels x alcohol consumption (drinks per week) interaction
Bioavailable testosterone levels x fluid intelligence interaction
Estradiol levels x smoking behaviour (cigarettes smoked per day) interaction
185,464 British ancestry men
Estradiol levels x alcohol consumption (drinks per week) interaction
189,153 British ancestry men
Estradiol levels x fluid intelligence interaction
73,236 British ancestry men
Sex hormone-binding globulin levels x smoking behaviour (cigarettes smoked per day) interaction
Sex hormone-binding globulin levels x alcohol consumption (drinks per week) interaction
Sex hormone-binding globulin levels x fluid intelligence interaction
Chymotrypsin C levels
1,301 European ancestry individuals
Cathepsin L1 levels
C-X-C motif chemokine 1 levels
Decorin levels
2,4-dienoyl-CoA reductase,mitochondrial levels
1,296 European ancestry individuals
Dickkopf-related protein 1 levels
Fatty acid-binding protein,intestinal levels
1,298 European ancestry individuals
1,286 European ancestry individuals
Follistatin levels
Galectin-9 levels
Growth/differentiation factor 2 levels
Growth hormone levels
Gastric intrinsic factor levels
1,299 European ancestry individuals
Lactoylglutathione lyase levels
Gastrotropin levels
1,047 European ancestry individuals
Hydroxyacid oxidase 1 levels
Proheparin-binding EGF-like growth factor levels
1,300 European ancestry individuals
Heme oxygenase 1 levels
Osteoclast-associated immunoglobulin-like receptor levels
Heat shock 27 kDa protein levels
Alpha-L-iduronidase levels
Low affinity immunoglobulin gamma Fc region receptor II-b levels
1,295 European ancestry individuals
Pro-interleukin-16 levels
Interleukin-17D levels
Interleukin-1-receptor antagonist levels
Interleukin-1 receptor-like 2 levels
Interleukin-27 levels
Interleukin-4 receptor subunit alpha levels
1,292 European ancestry individuals
Kidney Injury Molecule levels
Cutaneous malignant melanoma
36,760 European ancestry cases, 375,188 European ancestry controls
Cutaneous melanoma or hair colour
36,760 European ancestry cutaneous melanoma cases, 375,188 European ancestry controls, 352,662 European ancestry individuals
Nevus count or cutaneous melanoma
36,760 European ancestry cutaneous melanoma cases, 375,188 European ancestry controls, 12,930 European ancestry individuals, 52,847 individuals
Corneal astigmatism
69,140 European ancestry cases, 17,195 European ancestry controls
Refractive astigmatism
70,505 European ancestry cases, 17,500 European ancestry controls
Up to 86,335 European ancestry individuals
88,005 European ancestry individuals
Childhood body mass index
828 Mexican-Mestizo ancestry individuals
Body fat percentage
828 Mexican-Mestizo ancestry children
HDL cholesterol x physical activity interaction (2df test)
7,395 African American inactive individuals, 13,092 African American active individuals, 2,753 Asian ancestry inactive individuals, 3,650 Asian ancestry active individuals, 22,963 European ancestry inactive individuals, 61,939 European ancestry active individuals, 2,829 Hispanic or Latin American inactive individuals, 6,358 Hispanic or Latin American active individuals
1,886 African American inactive individuals, 1,892 African American active individuals, 1,217 South African Black ancestry inactive individuals, 389 South African Black ancestry active individuals, 2,494 East Asian ancestry inactive individuals, 1,947 East Asian ancestry active individuals, 724 South Asian ancestry inactive individuals, 1,425 South Asian ancestry active individuals, 41,042 European ancestry inactive individuals, 66,575 European ancestry active individuals, 2,619 Hispanic inactive individuals, 8,802 Hispanic active individuals
Affymetrix, Illumina [at least 2500000] (imputed)
LDL cholesterol x physical activity interaction (2df test)
7,260 African American inactive individuals, 12,761 African American active individuals, 2,740 Asian ancestry inactive individuals, 3,615 Asian ancestry active individuals, 22,378 European ancestry inactive individuals, 55,310 European ancestry active individuals, 2,163 Hispanic or Latin American inactive individuals, 3,461 Hispanic or Latin American active individuals
571 African American inactive individuals, 1,521 African American active individuals, 1,217 South African Black ancestry inactive individuals, 389 South African Black ancestry active individuals, 2,495 East Asian ancestry inactive individuals, 1,947 East Asian ancestry active individuals, 724 South Asian ancestry inactive individuals, 1,425 South Asian ancestry active individuals, 33,796 European ancestry inactive individuals, 50,812 European ancestry active individuals, 2,578 Hispanic inactive individuals, 8,661 Hispanic active individuals
Triglycerides x physical activity interaction (2df test)
7,294 African American inactive individuals, 12,832 African American active individuals, 1,352 Asian ancestry inactive individuals, 3,049 Asian ancestry active individuals, 20,622 European ancestry inactive individuals, 51,480 European ancestry active individuals, 2,166 Hispanic or Latin American inactive individuals, 3,486 Hispanic or Latin American active individuals
580 African American inactive individuals, 1,540 African American active individuals, 1,217 South African Black ancestry inactive individuals, 389 South African Black ancestry active individuals, 765 East Asian ancestry inactive individuals, 1,814 East Asian ancestry active individuals, 724 South Asian ancestry inactive individuals, 1,424 South Asian ancestry active individuals, 32,456 European ancestry inactive individuals, 49,510 European ancestry active individuals, 2,619 Hispanic inactive individuals, 8,803 Hispanic active individuals
LDL cholesterol x physical activity interaction (1df test)
HDL cholesterol x physical activity interaction (1df test)
Triglycerides x physical activity interaction (1df test)
Total body bone mineral density (MTAG)
at least 66,628 individuals
Heel bone mineral density (MTAG)
at least 142,487 individuals
Birth weight
188,039 European ancestry individuals
Refractive error
139,884 European ancestry individuals
Adiponectin levels
up to 60,465 European ancestry individuals, up to 2,568 East Asian ancestry individuals, up to 3,271 African American individuals, up to 1,435 Hispanic individuals
OTU99_271 (Prevotella) abundance
8,956 German ancestry individuals
OTU99_298 (Phascolarctobacterium) abundance
OTU99_3 (Bacteroides) abundance
OTU99_30 (Parasutterella) abundance
OTU99_32 (Prevotella) abundance
OTU99_34 (Holdemanella) abundance
OTU99_35 (Ruminococcus) abundance
OTU99_39 (Alphaproteobacteria) abundance
OTU99_4 (Alistipes) abundance
OTU99_40 (Proteobacteria) abundance
OTU99_45 (Faecalibacterium) abundance
OTU99_47 (Prevotella) abundance
OTU99_5 (Sutterella) abundance
OTU99_53 (Aestuariispira) abundance
OTU99_54 (Holdemanella) abundance
OTU99_55 (Barnesiella) abundance
OTU99_558 (Bacteroidales) abundance
OTU99_58 (Bacteroides) abundance
OTU99_59 (Prevotella) abundance
OTU99_6 (Sutterella) abundance
OTU99_62 (Ruminococcaceae) abundance
OTU99_65 (Sutterellaceae) abundance
OTU99_7 (Lachnospiraceae) abundance
OTU99_72 (Parabacteroides) abundance
OTU99_78 (Clostridiales) abundance
O_Clostridiales abundance
O_Coriobacteriales abundance
OTU97_165 (Porphyromonadaceae) abundance
OTU97_17 (Parabacteroides) abundance
OTU97_173 (Bacteroides) abundance
OTU97_19 (Bacteria) abundance
OTU97_1 (Bacteroides) abundance
OTU97_100 (Ruminococcaceae) abundance
OTU97_101 (Sutterella) abundance
OTU97_257 (Mitsuokella) abundance
OTU97_105 (Ruminococcaceae) abundance
OTU97_106 (Ruminococcaceae) abundance
OTU97_30 (Roseburia) abundance
OTU97_31 (Prevotella) abundance
OTU97_33 (Holdemanella) abundance
OTU97_11 (Parabacteroides) abundance
OTU97_113 (Bacteroidales) abundance
OTU97_4 (Alistipes) abundance
OTU97_119 (Desulfovibrio) abundance
OTU97_12 (Bacteroides) abundance
OTU97_126 (Prevotella) abundance
OTU97_13 (Subdoligranulum) abundance
OTU97_130 (Butyrivibrio) abundance
OTU97_137 (Catenibacterium) abundance
OTU97_138 (Oscillibacter) abundance
OTU97_140 (Bacteroides) abundance
OTU97_15 (Parasutterella) abundance
OTU97_150 (Bacteroides) abundance
OTU99_12 (Bacteroides) abundance
OTU99_120 (Ruminococcaceae) abundance
OTU99_121 (Ruminococcaceae) abundance
OTU99_123 (Phascolarctobacterium) abundance
OTU99_124 (Paraprevotella) abundance
OTU99_13 (Subdoligranulum) abundance
OTU99_132 (Bacteroidales) abundance
OTU99_137 (Ruminococcus) abundance
OTU99_140 (Desulfovibrio) abundance
OTU99_150 (Prevotella) abundance
OTU99_155 (Butyrivibrio) abundance
OTU99_157 (Barnesiella) abundance
OTU99_16 (Faecalibacterium) abundance
OTU99_166 (Prevotella) abundance
OTU99_17 (Parabacteroides) abundance
OTU99_171 (Bacteroides) abundance
OTU99_19 (Bacteria) abundance
OTU99_197 (Bacteroides) abundance
OTU99_2 (Bacteroides) abundance
OTU99_21 (Parasutterella) abundance
OTU99_211 (Bacteroides) abundance
OTU99_23 (Faecalibacterium) abundance
P_Actinobacteria abundance
OTU99_24 (Prevotella) abundance
OTU99_26 (Parasutterella) abundance
OTU99_8 (Ruminococcaceae) abundance
OTU99_84 (Prevotella) abundance
OTU99_85 (Alistipes) abundance
OTU99_9 (Alistipes) abundance
OTU99_92 (Ruminococcus) abundance
OTU99_94 (Bacteroides) abundance
OTU99_98 (Phascolarctobacterium) abundance
P_Bacteroidetes abundance
P_Firmicutes abundance
P_Proteobacteria abundance
TestASV_1 (Bacteroides) abundance
TestASV_10 (Parabacteroides) abundance
TestASV_11 (Lachnospiraceae) abundance
TestASV_12 (Bacteroides) abundance
TestASV_13 (Bacteroides) abundance
TestASV_14 (Lachnospiraceae) abundance
TestASV_15 (Bacteroides) abundance
TestASV_16 (Bacteroides) abundance
TestASV_17 (Bacteroides) abundance
TestASV_18 (Prevotella) abundance
TestASV_19 (Prevotella) abundance
TestASV_2 (Bacteroides) abundance
TestASV_20 (Phascolarctobacterium) abundance
TestASV_21 (Ruminococcaceae) abundance
TestASV_22 (Sutterella) abundance
OTU97_5 (Sutterella) abundance
OTU97_50 (Aestuariispira) abundance
OTU97_51 (Barnesiella) abundance
OTU97_53 (Bacteroides) abundance
OTU97_56 (Ruminococcaceae) abundance
OTU97_58 (Sutterellaceae) abundance
OTU97_6 (Sutterella) abundance
OTU97_65 (Parabacteroides) abundance
OTU97_69 (Clostridiales) abundance
OTU97_7 (Lachnospiraceae) abundance
OTU97_73 (Prevotella) abundance
OTU97_74 (Alistipes) abundance
OTU97_8 (Ruminococcaceae) abundance
OTU97_80 (Ruminococcus) abundance
OTU97_82 (Bacteroides) abundance
OTU97_86 (Phascolarctobacterium) abundance
OTU97_9 (Alistipes) abundance
OTU97_95 (Cytophagales) abundance
OTU97_97 (Clostridiales) abundance
OTU99_1 (Bacteroides) abundance
OTU99_106 (Barnesiella) abundance
OTU99_108 (Cytophagales) abundance
OTU99_11 (Parabacteroides) abundance
OTU99_110 (Clostridiales) abundance
OTU99_116 (Sutterella) abundance
OTU97_16 (Faecalibacterium) abundance
OTU97_163 (Bacteroides) abundance
O_Erysipelotrichales abundance
O_Selenomonadales abundance
OTU97_2 (Bacteroides) abundance
OTU97_21 (Parasutterella) abundance
OTU97_23 (Faecalibacterium) abundance
OTU97_235 (Phascolarctobacterium) abundance
OTU97_24 (Prevotella) abundance
OTU97_102 (Prevotella) abundance
OTU97_26 (Parasutterella) abundance
OTU97_27 (Bacteroides) abundance
OTU97_277 (Prevotella) abundance
OTU97_3 (Bacteroides) abundance
OTU97_108 (Phascolarctobacterium) abundance
OTU97_109 (Paraprevotella) abundance
OTU97_34 (Ruminococcus) abundance
OTU97_354 (Alloprevotella) abundance
OTU97_38 (Alphaproteobacteria) abundance
OTU97_39 (Proteobacteria) abundance
OTU97_117 (Ruminococcus) abundance
OTU97_46 (Lachnospiraceae) abundance
Chronic postoperative pain
34 European ancestry cases, 269 European ancestry controls
11 European ancestry cases, 39 European ancestry controls
Refractive error (age-at-onset of spectacle wearing-inferred)
287,448 European ancestry individuals
Refractive error (autorefraction measured)
95,619 European ancestry individuals
Serum immune biomarker levels
184 Scandinavian ancestry bipolar disorder cases, 107 Scandinavian ancestry controls
Affymetrix, Illumina [> 5000000] (imputed)
Cerebrospinal fluid immune biomarker levels
114 Scandinavian ancestry bipolar disorder cases, 83 Scandinavian ancestry controls
Affymetrix, Illumina [> 5600000] (imputed)
LDL cholesterol change in response to niacin in statin-treated individuals
up to 1,034 European ancestry cases, up to 1,020 European ancestry controls
Triglycerides levels in response to niacin in statin-treated individuals
Total cholesterol change in response to niacin in statin-treated individuals
Lipoprotein (a) levels in response to niacin in statin-treated individuals
HDL cholesterol change in response to niacin in statin-treated individuals
601 Japanese ancestry cases, 1,962 Japanese ancestry controls
1,075 Japanese ancestry cases, 419 Japanese ancestry controls
Obsessive compulsive disorder severity
376 Spanish ancestry individuals
Compulsion score in obsessive compulsive disorder
Obsession score in obsessive compulsive disorder
151,836 British ancestry cases, 255,230 British ancestry controls
90,806 British ancestry male cases, 99,165 British ancestry male controls
61,792 British ancestry female cases, 156,554 British ancestry female controls
152,302 British ancestry cases, 256,015 British ancestry controls
70,700 European ancestry female individuals, 85,261 European ancestry male individuals
Fat-free mass
Idiopathic downbeat nystagmus
106 European ancestry cases, 2,609 European ancestry controls
Vascular endothelial growth factor levels in major depressive disorder
121 European ancestry individuals
Vascular endothelial growth factor levels
145 European ancestry individuals
Adipose morphology
894 individuals
Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide)
67 Japanese ancestry responders, 133 Japanese ancestry poor responders
Levodopa wearing off effect (motor symptom score change) in Parkinson's disease (response to zonisamide)
Inhibin B levels
811 Japanese ancestry individuals
721 Japanese ancestry individuals
Semen volume
Sperm concentration
Testis size
21,014 Korean ancestry individuals with TG < 150mg/dL, 7,424 Korean ancestry individuals with TG ≥ 150 mg/dL
COVID-19 (hospitalized vs population) RELEASE 4
6,406 European ancestry hospitalized cases, 902,088 European ancestry controls, 873 Latin American hospitalized cases, 2,222 Latin American controls, 62 South Asian ancestry hospitalized cases, 27,353 South Asian ancestry controls, 60 Arab ancestry hospitalized cases, 13,360 Arab ancestry controls, 415 African ancestry hospitalized cases, 10,281 African ancestry controls, 69 East Asian ancestry hospitalized cases, 6,500 East Asian ancestry controls
Genome-wide genotyping array, Genome-wide sequencing, Exome-wide sequencing
COVID-19 (covid vs lab/self reported negative) RELEASE 4
8,818 Europen ancestry cases, 101,806 European ancestry controls, 114 South Asian ancestry cases, 256 South Asian ancestry controls, 63 African ancestry cases, 125 African ancestry controls, 66 Central/South Asian ancestry cases, 350 Central/South Asian ancestry controls, 576 Latin American cases, 3,601 Latin American controls
COVID-19 (hospitalized vs not hospitalized) RELEASE 5
4,829 European ancestry cases, 11,816 European ancestry controls, 186 South Asian ancestry cases, 1,494 South Asian ancestry controls, 486 African ancestry cases, 1,081 African ancestry controls, 60 Arab ancestry cases, 640 Arab ancestry controls, 117 Hispanic cases, 392 Hispanic controls, 95 Admixed American ancestry cases, 75 Admixed American ancestry controls
3,159 European ancestry cases, 7,206 European ancestry controls, 115 South Asian ancestry cases, 1,264 South Asian ancestry controls, 415 African ancestry cases, 962 African ancestry controls, 60 Arab ancestry cases, 640 Arab ancestry controls, 117 Hispanic cases, 392 Hispanic controls, 95 Admixed American ancestry cases, 74 Admixed American ancestry controls
6,406 European ancestry cases, 902,088 European ancestry controls
Genome-wide genotyping array, Exome-wide sequencing, Genome-wide sequencing
COVID-19 (RELEASE 4)
14,134 European ancestry cases, 1,284,876 European ancestry controls
COVID-19 (very severe respiratory confirmed vs not hospitalized) RELEASE 4
269 European ancestry cases, 688 European ancestry controls
COVID-19 (RELEASE 5)
29,071 European ancestry cases, 1,559,712 European ancestry controls, 576 Latin American cases, 4,955 Latin American controls, 1,495 East Asian ancestry cases, 15,499 East Asian ancestry controls, 1,688 South Asian ancestry cases, 42,016 South Asian ancestry controls, 2,038 African ancestry cases, 28,066 African ancestry controls, 700 Arab ancestry cases, 13,360 Arab ancestry controls, 1,022 Admixed American ancestry cases, 5,330 Admixed American ancestry controls
31,562 European ancestry cases, 1,026,848 European ancestry controls, 2,619 Latin American cases, 15,491 Latin American controls, 1,495 East Asian ancestry cases, 15,499 East Asian ancestry controls, 1,379 South Asian ancestry cases, 32,785 South Asian ancestry controls, 2,338 African ancestry cases, 23,485 African ancestry controls, 700 Arab ancestry cases, 13,360 Arab ancestry controls, 1,022 Admixed American ancestry cases, 5,330 Admixed American ancestry controls
38,984 European ancestry cases, 1,644,784 European ancestry controls
32,494 European ancestry cases, 1,316,207 European ancestry controls
COVID-19 (very severe respiratory confirmed vs population) RELEASE 3
435 European ancestry cases, 327,858 European ancestry controls, 101 Latin American cases, 1,533 Latin American controls
COVID-19 (hospitalized vs not hospitalized) RELEASE 3
928 European ancestry cases, 2,028 European ancestry controls
COVID-19 (hospitalized vs population) RELEASE 3
2,961 European ancestry hospitalized cases, 868,602 European ancestry controls, 176 Latin American hospitalized cases, 1,533 Latin American controls, 62 South Asian ancestry hospitalized cases, 27,353 South Asian ancestry controls
COVID-19 (covid vs lab/self reported negative) RELEASE 3
3,289 Europen ancestry cases, 36,125 European ancestry controls, 114 South Asian ancestry cases, 256 South Asian ancestry controls, 63 African ancestry cases, 125 African ancestry controls, 57 Central/South Asian ancestry cases, 128 Central/South Asian ancestry controls
COVID-19 (RELEASE 3)
6,089 European ancestry cases, 1,015,145 European ancestry controls, 197 Arab ancestry cases, 13,698 Arab ancestry cases, 176 Latin American cases, 1,533 Latin American controls, 114 South Asian ancestry cases, 27,301 South Asian ancestry controls, 63 African ancestry cases, 6,573 African ancestry controls, 57 Central/South Asian ancestry cases, 8,819 Central/South Asian ancestry controls
COVID-19 (predicted from self-reported symptoms vs predicted or self-reported non-covid) RELEASE 3
1,865 European ancestry cases, 29,174 European ancestry controls
COVID-19 (very severe respiratory confirmed vs population) RELEASE 5
5,101 European ancestry cases, 1,383,241 European ancestry controls
4,606 European ancestry cases, 702,801 European ancestry controls, 539 Latin American cases, 1,149 Latin American controls, 133 African American cases, 2,610 African American controls, 304 East Asian ancestry cases, 2,450 East Asian ancestry controls
4,792 European ancestry cases, 1,054,664 European ancestry controls, 641 Latin American cases, 96,479 Latin American controls, 133 African American cases, 2,610 African American controls, 304 East Asian ancestry cases, 2,450 East Asian ancestry controls
4,792 European ancestry cases, 1,054,664 European ancestry controls
3,159 European ancestry cases, 7,206 European ancestry controls
4,829 European ancestry cases, 11,816 European ancestry controls
COVID-19 (hospitalized vs population) RELEASE 5
9,986 European ancestry cases, 1,877,672 European ancestry controls
8,316 European ancestry cases, 1,549,095 European ancestry controls, 257 Latin American cases, 94,912 Latin American controls, 115 South Asian ancestry cases, 34,049 South Asian ancestry controls, 60 Arab ancestry cases, 13,360 Arab ancestry controls, 653 African ancestry cases, 4,355 African ancestry controls, 1,414 East Asian ancestry cases, 15,499 East Asian ancestry controls, 948 Admixed American ancestry cases, 5,404 Admixed American ancestry controls
8,316 European ancestry cases, 1,549,095 European ancestry controls
9,373 European ancestry cases, 1,197,256 European ancestry controls, 117 Latin American cases, 585 Latin American controls, 186 South Asian ancestry cases, 43,280 South Asian ancestry controls, 60 Arab ancestry cases, 13,360 Arab ancestry controls, 790 African ancestry cases, 20,582 African ancestry controls, 1,414 East Asian ancestry cases, 15,499 East Asian ancestry controls, 948 Admixed American ancestry cases, 5,404 Admixed American ancestry controls
14,134 European ancestry cases, 1,284,876 European ancestry controls, 1,332 Latin American cases, 6,592 Latin American controls, 66 Central Asian ancestry cases, 8,487 Central Asian ancestry controls, 108 East Asian ancestry cases, 6,500 East Asian ancestry controls, 114 South Asian ancestry cases, 27,301 South Asian ancestry controls, 1,511 African ancestry cases, 23,431 African ancestry controls, 700 Arab ancestry cases, 13,360 Arab ancestry controls
COVID-19 (very severe respiratory confirmed vs population) RELEASE 4
3,886 European ancestry cases, 622,265 European ancestry controls, 450 Latin American cases, 1,637 Latin American controls
COVID-19 (hospitalized covid vs not hospitalized) RELEASE 4
1,776 European ancestry cases, 6,443 European ancestry controls, 62 South Asian ancestry cases, 41 South Asian ancestry controls, 415 African ancestry cases, 962 African ancestry controls, 60 Arab ancestry cases, 640 Arab ancestry controls, 117 Hispanic cases, 392 Hispanic controls
COVID-19 (predicted covid from self-reported symptoms vs predicted or self-reported non-covid) RELEASE 4
3,204 European ancestry cases, 35,728 European ancestry controls
Neuroblastoma or malignant cutaneous melanoma
2,101 European ancestry neuroblastoma cases, 12,874 European ancestry malignant cutaneous melanoma cases, 27,405 European ancestry controls
2,039 European ancestry neuroblastoma cases, 508 European ancestry malignant cutaneous melanoma cases, 3,469 European ancestry controls
Proportion of activated microglia (midfrontal cortex)
225 individuals
Proportion of activated microglia (inferior temporal cortex)
219 individuals
COVID-19 (critical illness vs population)
2,804 European ancestry cases, 2,415 European, South Asian and Hispanic or Latin American ancestry cases, 687,911 European ancestry controls, 477,741 European, South Asian and Hispanic or Latin American ancestry controls
182 African ancestry cases, 910 African ancestry controls
149 East Asian ancestry cases, 745 East Asian ancestry controls
1,676 European ancestry cases, 8,380 European ancestry controls
2,415 European, South Asian and Hispanic or Latin American ancestry cases, 477,741 European, South Asian and Hispanic or Latin American ancestry controls, 1,128 European ancestry cases, 679,531 European ancestry controls
237 South Asian ancestry cases, 1,185 South Asian ancestry controls
Sortilin levels
Lipoprotein lipase levels
Serine/threonine-protein kinase 4 levels
1,095 European ancestry individuals
Tyrosine-protein kinase Mer levels
Protein-glutamine gamma-glutamyltransferase 2 levels
1,291 European ancestry individuals
Matrix metalloproteinase-7 levels
Thrombopoietin levels
Angiopoietin-1 receptor levels
Thrombomodulin levels
Tumor necrosis factor receptor superfamily member 10A levels
Platelet-derived growth factor subunit B levels
Programmed cell death 1 ligand 2 levels
TNF-related apoptosis-inducing ligand receptor 2 levels
vascular endothelial growth factor D levels
V-set and immunoglobulin domain-containing protein 2 levels
XCL1 levels
1,280 European ancestry individuals
CD166 antigen levels
1,323 European ancestry individuals
P-selectin glycoprotein ligand 1 levels
Tyrosine-protein kinase receptor UFO levels
Receptor for advanced glycosylation end products levels
Renin levels
Serpin A12 levels
C-C motif chemokine 24 levels
Superoxide dismutase [Mn],mitochondrial levels
Leptin levels
Spondin-2 levels
Macrophage receptor MARCO levels
Tissue factor levels
Matrix metalloproteinase-12 levels
Thrombospondin-2 levels
NF-kappa-B essential modulator levels
Pappalysin-1 levels
Proteinase-activated receptor 1 levels
Poly [ADP-ribose] polymerase 1 levels
823 European ancestry individuals
Tumor necrosis factor receptor superfamily member 11A levels
Tumor necrosis factor receptor superfamily member 13B levels
Placenta growth factor levels
Polymeric immunoglobulin receptor levels
Prolargin levels
Serine protease 27 levels
Prostasin levels
Aminopeptidase N levels
Pentraxin-related protein PTX3 levels
Azurocidin levels
Bleomycin hydrolase levels
Caspase-3 levels
C-C motif chemokine 15 levels
C-C motif chemokine 16 levels
SLAM family member 7 levels
Bipolar disorder or intelligence (pleiotropy)
20,352 European ancestry bipolar disorder cases, 31,358 European ancestry controls, 269,867 individuals
Schizophrenia or intelligence (pleiotropy)
35,476 European and East Asian ancestry schizophrenia cases, 46,839 European and East Asian ancestry controls, 269,867 individuals
Lifetime anxiety disorder
25,453 European ancestry cases, 58,113 European ancestry controls
6,524 cases, 24001 controls
Anxiety symptoms
19,012 European ancestry cases, 58,113 European ancestry controls
Intrinsic epigenetic age acceleration
13,493 European ancestry individuals
Extrinsic epigenetic age acceleration
Severe malarial anemia in Plasmodium falciparum infection
70 child cases, 74 child controls
165 Kenyan ancestry child cases, 718 Kenyan ancestry child controls
83,884 European ancestry individuals, 9,610 African American individuals, 1,382 Hispanic individuals, 750 East Asian ancestry individuals.
JT interval
up to 83,884 European ancestry individuals, up to 9,610 African American individuals, up to 1,382 Hispanic individuals, up to750 East Asian ancestry individuals.
Sclerostin levels
1,312 European ancestry individuals
Scavenger receptor cysteine-rich domain-containing group B protein levels
1,272 European ancestry individuals
Sulfatase-modifying factor 2 levels
Trefoil factor 2 levels
1,313 European ancestry individuals
Thimet oligopeptidase levels
Thyrotropin subunit beta levels
1,285 European ancestry individuals
Thioredoxin domain-containing protein 5 levels
1,309 European ancestry individuals
Thymidine phosphorylase levels
Tyrosine-protein kinase receptor TYRO3 levels
Ubiquitin carboxyl-terminal hydrolase 8 levels
1,138 European ancestry individuals
Versican core protein levels
Angiotensin-converting enzyme 2 levels
A disintegrin and metalloproteinase with thrombospondin motifs 13 levels
Agouti-related protein levels
Protein AMBP levels
Angiopoietin-1 levels
Bone morphogenetic protein 6 levels
1,214 European ancestry individuals
Brother of CDO levels
Carbonic anhydrase 5A,mitochondrial levels
1,263 European ancestry individuals
C-C motif chemokine 17 levels
C-C motif chemokine 3 levels
1,288 European ancestry individuals
T-cell surface glycoprotein CD4 levels
CD40 ligand levels
SLAM family member 5 levels
Carcinoembryonic antigenrelated cell adhesion molecule 8 levels
C-type lectin domain family 5 member A levels
CXADR-like membrane protein levels
Calsyntenin-2 levels
Clusterin-like protein 1 levels
Catechol O-methyltransferase levels
1,239 European ancestry individuals
Crk-like protein levels
1,105 European ancestry individuals
Pro-cathepsin H levels
1,278 European ancestry individuals
Cathepsin O levels
Aromatic-L-amino-acid decarboxylase levels
180 European ancestry individuals
Dipeptidyl peptidase 2 levels
1,290 European ancestry individuals
Gamma-enolase levels
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 levels
Ectonucleoside triphosphate diphosphohydrolase 5 levels
Protein FAM3C levels
Fructose-1,6-bisphosphatase 1 levels
1,174 European ancestry individuals
Fc receptor-like protein 1 levels
Peptidyl-prolyl cis-trans isomerase FKBP4 levels
1,120 European ancestry individuals
Galanin peptide levels
Glutaredoxin-1 levels
1,227 European ancestry individuals
GRB2-related adapter protein 2 levels
923 European ancestry individuals
Insulin-like growth factor-binding protein-like 1 levels
Integrin beta-7 levels
1,211 European ancestry individuals
Kallikrein-10 levels
Kynurenine-oxoglutarate transaminase 1 levels
Leukocyte immunoglobulin-like receptor subfamily A member 5 levels
Leucine-rich repeats and immunoglobulin-like domains protein 1 levels
Low-density lipoprotein receptor-related protein 11 levels
Multiple coagulation factor deficiency protein 2 levels
Meprin A subunit beta levels
1,200 European ancestry individuals
Meteorin-like protein levels
NAD kinase levels
Nectin-2 levels
Nodal modulator 1 levels
Neural proliferation differentiation and control protein 1 levels
Neuronal pentraxin receptor levels
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 levels
1,308 European ancestry individuals
Paired immunoglobulin-like type 2 receptor beta levels
Protein phosphatase inhibitor 2 levels
Dihydropteridine reductase levels
Regenerating islet-derived protein 4 levels
Eosinophil cationic protein levels
Inactive tyrosine-protein kinase transmembrane receptor ROR1 levels
Reticulon-4 receptor levels
Protein S100-A12 levels
1,100 European ancestry individuals
Syndecan-4 levels
Semaphorin-3F levels
Serpin B6 levels
Serpin B8 levels
Sialic acid-binding Ig-like lectin 7 levels
Synaptosomal-associated protein 23 levels
Tartrate-resistant acid phosphatase type 5 levels
Urokinase plasminogen activator surface receptor levels
Lysophosphatidic acid phosphatase type 6 levels
1,311 European ancestry individuals
Adhesion G protein-coupled receptor E2 levels
Adhesion G-protein coupled receptor G2 levels
Retinal dehydrogenase 1 levels
Angiopoietin-2 levels
Angiopoietin-related protein 1 levels
Angiopoietin-related protein 7 levels
1,306 European ancestry individuals
DNA-(apurinic or apyrimidinic site) lyase levels
1,187 European ancestry individuals
Amyloid-like protein 1 levels
Arginase-1 levels
1,072 European ancestry individuals
Large proline-rich protein BAG6 levels
Carbonic anhydrase 13 levels
1,248 European ancestry individuals
Soluble calcium-activated nucleotidase 1 levels
Coiled-coil domain-containing protein 80 levels
Sialomucin core protein 24 levels
T-cell surface glycoprotein CD1c levels
CD2-associated protein levels
B-cell antigen receptor complex-associated protein beta chain levels
Cadherin-2 levels
Cadherin-related family member 5 levels
Chordin-like protein 2 levels
1,279 European ancestry individuals
Insulin-like growth factor-binding protein 7 levels
Interleukin-17 receptor A levels
Interleukin-18-binding protein levels
Interleukin-1 receptor type 1 levels
Interleukin-1 receptor type 2 levels
Interleukin-2 receptor subunit alpha levels
Interleukin-6 receptor subunit alpha levels
Integrin beta-2 levels
Junctional adhesion molecule A levels
Kallikrein-6 levels
Low-density lipoprotein receptor levels
Lymphotoxin-beta receptor levels
Myoglobin levels
1,322 European ancestry individuals
Matrix extracellular phosphoglycoprotein levels
974 European ancestry individuals
Matrix metalloproteinase-2 levels
Matrix metalloproteinase-3 levels
Matrix metalloproteinase-9 levels
Myeloperoxidase levels
Neurogenic locus notch homolog protein 3 levels
1,243 European ancestry individuals
Osteopontin levels
Plasminogen activator inhibitor-1 (PAI-1) levels
Proprotein convertase subtilisin/kexin type 9 levels
Platelet-derived growth factor subunit A levels
Platelet endothelial cell adhesion molecule levels
Peptidoglycan recognition protein 1 levels
Elafin levels
Perlecan levels
Paraoxonase activity
Myeloblastin levels
Pulmonary surfactant-associated protein D levels
1,316 European ancestry individuals
Retinoic acid receptor responder protein 2 levels
Resistin levels
Secretoglobin family 3A member 2 levels
E-selectin levels
P-selectin levels
Tyrosine-protein phosphatase non-receptor type substrate 1 levels
Spondin-1 levels
1,314 European ancestry individuals
ST2 protein levels
Tissue factor pathway inhibitor levels
Metalloproteinase inhibitor 4 levels
Trem-like transcript 2 protein levels
Tumor necrosis factor receptor 1 levels
Tumor necrosis factor receptor 2 levels
Tumor necrosis factor receptor superfamily member 10C levels
Tumor necrosis factor receptor superfamily member 14 levels
Tumor necrosis factor ligand superfamily member 13B levels
Tissue-type plasminogen activator levels
Transferrin receptor protein 1 levels
Scavenger receptor cysteine-rich type 1 protein M130 levels
Complement component C1q receptor levels
Cadherin-5 levels
Chitinase-3-like protein 1 levels
Chitotriosidase-1 levels
Contactin-1 levels
Collagen alpha-1 (I) chain levels
Carboxypeptidase A1 levels
Carboxypeptidase B levels
Cystatin-B levels
Cathepsin D levels
Cathepsin Z levels
C-X-C motif chemokine 16 levels
Protein delta homolog 1 levels
Epidermal growth factor levels
epithelial cell adhesion molecule levels
Ephrin type-B receptor 4 levels
Fatty acid-binding protein, adipocyte levels
Tumor necrosis factor receptor superfamily member 6 levels
Galectin-3 levels
Galectin-4 levels
Granulins levels
Intercellular adhesion molecule 2 levels
Insulin-like growth factor-binding protein 1 levels
Insulin-like growth factor-binding protein 2 levels
Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes)
553 European ancestry individuals, 1,346 individuals
Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-120 minutes)
Glucagon levels in response to oral glucose tolerance test (fasting)
Glucagon levels in response to oral glucose tolerance test (30 minutes)
Glucagon levels in response to oral glucose tolerance test (120 minutes)
Nucleoside diphosphate kinase A levels in hepatocellular carcinoma
408 East Asian ancestry individuals
Retinal detachment
4,257 European ancestry cases, 39,181 European ancestry controls
Spherical equivalent
95,827 European ancestry individuals
101,939 European ancestry cases
Appendicular lean mass
85,750 European ancestry middle-aged adult individuals
181,862 European ancestry elderly individuals
24,814 European ancestry individuals
6,526 European ancestry individuals
Carotid intima media thickness (mean)
10,708 British ancestry men, 11,471 British ancestry women
Carotid intima media thickness (maximum)
22,179 British ancestry individuals
Carotid intima media thickness (mean-maximum)
Polycystic ovary syndrome (reproductive subtype)
123 European ancestry cases, 2,964 European ancestry controls
84 European ancestry cases, 1,134 European ancestry controls
Polycystic ovary syndrome (metabolic subtype)
201 European ancestry cases, 2,964 European ancestry controls
128 European ancestry cases, 1,134 European ancestry controls
Polycystic ovary syndrome (indeterminate subtype)
231 European ancestry cases, 2,964 European ancestry controls
126 European ancestry cases, 1,134 European ancestry controls
450 Japanese ancestry cases, 5,774 Japanese ancestry controls
Intracerebral hemorrhage
261 Japanese ancestry intracerebral hemorrhage cases, 176 Japanese ancestry subarachnoid hemorrhage cases, 5,742 Japanese ancestry controls
18,670 European ancestry individuals, 1,207 East Asian ancestry individuals, 1,514 Hispanic/Latino individuals, 764 African American individuals
4,483 European ancestry individuals
23,153 European ancestry individuals, 1,207 East Asian ancestry individuals, 1,514 Hispanic/Latino individuals, 764 African American individuals
OTU99_8 (Ruminococcaceae) prevalence
OTU99_84 (Prevotella) prevalence
OTU99_85 (Alistipes) prevalence
OTU99_9 (Alistipes) prevalence
OTU99_92 (Ruminococcus) prevalence
OTU99_94 (Bacteroides) prevalence
OTU99_98 (Phascolarctobacterium) prevalence
TestASV_1 (Bacteroides) prevalence
TestASV_10 (Parabacteroides) prevalence
TestASV_11 (Lachnospiraceae) prevalence
TestASV_12 (Bacteroides) prevalence
TestASV_13 (Bacteroides) prevalence
TestASV_14 (Lachnospiraceae) prevalence
TestASV_15 (Bacteroides) prevalence
TestASV_16 (Bacteroides) prevalence
TestASV_17 (Bacteroides) prevalence
TestASV_18 (Prevotella) prevalence
TestASV_19 (Prevotella) prevalence
TestASV_2 (Bacteroides) prevalence
C_Actinobacteria abundance
C_Alphaproteobacteria abundance
C_Bacteroidia abundance
C_Betaproteobacteria abundance
C_Clostridia abundance
C_Erysipelotrichia abundance
G_Holdemanella abundance
G_Lachnospiraceae abundance
G_Oscillibacter abundance
G_Parabacteroides abundance
G_Paraprevotella abundance
G_Parasutterella abundance
G_Phascolarctobacterium abundance
G_Porphyromonadaceae abundance
G_Prevotella abundance
G_Prevotellaceae abundance
G_Roseburia abundance
G_Ruminococcaceae abundance
G_Ruminococcus abundance
G_Ruminococcus2 abundance
G_Subdoligranulum abundance
G_Sutterella abundance
O_Bacteroidales abundance
O_Burkholderiales abundance
TestASV_20 (Phascolarctobacterium) prevalence
TestASV_21 (Ruminococcaceae) prevalence
TestASV_22 (Sutterella) prevalence
TestASV_23 (Barnesiella) prevalence
TestASV_24 (Bacteroides) prevalence
TestASV_25 (Sutterella) prevalence
TestASV_26 (Phascolarctobacterium) prevalence
TestASV_27 (Ruminococcaceae) prevalence
TestASV_28 (Holdemanella) prevalence
TestASV_29 (Barnesiella) prevalence
TestASV_3 (Bacteroides) prevalence
TestASV_30 (Paraprevotella) prevalence
TestASV_31 (Ruminococcus) prevalence
TestASV_32 (Ruminococcaceae) prevalence
TestASV_33 (Paraprevotella) prevalence
TestASV_34 (Phascolarctobacterium) prevalence
TestASV_35 (Alphaproteobacteria) prevalence
TestASV_36 (Aestuariispira) prevalence
TestASV_37 (Ruminococcaceae) prevalence
TestASV_38 (Ruminococcus) prevalence
TestASV_39 (Bacteroides) prevalence
TestASV_4 (Alistipes) prevalence
TestASV_40 (Barnesiella) prevalence
TestASV_41 (Barnesiella) prevalence
TestASV_42 (Alphaproteobacteria) prevalence
TestASV_43 (Parasutterella) prevalence
TestASV_44 (Parasutterella) prevalence
TestASV_45 (Clostridiales) prevalence
TestASV_46 (Sutterella) prevalence
TestASV_47 (Parasutterella) prevalence
TestASV_48 (Sutterella) prevalence
TestASV_49 (Parasutterella) prevalence
C_Gammaproteobacteria abundance
C_Negativicutes abundance
F_Acidaminococcaceae abundance
F_Bacteroidaceae abundance
F_Coriobacteriaceae abundance
F_Erysipelotrichaceae abundance
F_Lachnospiraceae abundance
F_Porphyromonadaceae abundance
F_Prevotellaceae abundance
F_Rikenellaceae abundance
F_Ruminococcaceae abundance
F_Sutterellaceae abundance
G_Alistipes abundance
G_Alloprevotella abundance
G_Alphaproteobacteria abundance
G_Bacteroidales abundance
G_Bacteroides abundance
G_Bacteroidetes abundance
G_Barnesiella abundance
G_Catenibacterium abundance
G_Clostridiales abundance
G_Clostridium_XlVa abundance
G_Coprococcus abundance
G_Faecalibacterium abundance
G_Firmicutes abundance
Anxiety
175,163 European ancestry individuals, 24,448 African American individuals
Anxiety disorders
28,525 European ancestry cases, 5,664 African American cases, 163,731 European ancestry controls, 26,410 African American controls
TestASV_5 (Bacteroides) prevalence
TestASV_6 (Subdoligranulum) prevalence
TestASV_7 (Bacteroides) prevalence
TestASV_8 (Bacteroides) prevalence
TestASV_9 (Alistipes) prevalence
4,457 Korean ancestry individuals
2,031 Korean ancestry individuals
Alanine transaminase levels
up to 7,526 African ancestry individuals
Affymetrix, Illumina [at least 24423923] (imputed)
14,126 African ancestry individuals
up to 9,004 African ancestry individuals
Serum albumin level
Parkinson's disease
20,184 European ancestry cases, 397,324 European ancestry controls
Parkinson's disease or schizophrenia
34,875 European ancestry schizophrenia cases, 20,184 European ancestry Parkinson's disease cases, 440,781 European ancestry controls
Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension
290 African American individuals, 397 European ancestry individuals
Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension
Systolic blood pressure response to chlorthalidone in hypertension
142 African American individuals, 175 European ancestry individuals
Diastolic blood pressure response to chlorthalidone in hypertension
Relative fat intake
175,253 European ancestry individuals
93,179 European ancestry individuals
Relative protein intake
Relative carbohydrate intake
Relative sugar intake
59,454 European ancestry individuals
426,824 individuals
66,628 individuals
Affymetrix, Illumina [7369691] (imputed)
35,606 African American individuals, 26,048 Hispanic/Latino individuals, 22,466 Asian or Native Hawaiian ancestry individuals, 17,859 European ancestry individuals, 535 Native American individuals
Salivary metabolite levels
1,419 European ancestry individuals
1,000 European ancestry individuals
Vertical cup-disc ratio (adjusted for vertical disc diameter)
67,040 British ancestry individuals
Vertical cup-disc ratio (multi-trait analysis)
90,939 European ancestry individuals
Affymetrix, Illumina [8002429] (imputed)
133,492 European ancestry individuals
7,947 British ancestry cases, 119,318 British ancestry controls
Glaucoma (multi-trait analysis)
133,492 European ancestry individuals with intraocular pressure measurements, 90,939 European ancestry individuals with vertical cup-disc ratio measurements, 7,947 British ancestry glaucoma cases, 119,318 British ancestry controls
6,924 European ancestry glaucoma cases, 40,230 European ancestry controls
Angioedema in response to angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker
172 European ancestry cases, 1 case, 4,890 European ancestry controls
172 European ancestry cases, 1 case, 1,345 European ancestry treated controls
347 European ancestry cases, 66 African ancestry cases, 440 European ancestry treated controls, 157 African ancestry treated controls
Graft survival time in renal transplantation (donor effect)
532 African American donors
250 African American donors
Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction
Physiological dysregulation (Mahalanobis distance)
4,608 European ancestry individuals
Hand grip strength (Mahalanobis distance)
Midline nonsyndromic craniosynostosis
345 European ancestry trios
Metopic nonsyndromic craniosynostosis
215 European ancestry trios
194 European ancestry cases, 333 European ancestry controls
High-altitude pulmonary edema
96 Indo-Aryan ancestry cases, 96 Indo-Aryan ancestry controls
200 cases, 200 controls
G_Prevotella prevalence
G_Prevotellaceae prevalence
G_Ruminococcus prevalence
G_Sutterella prevalence
O_Selenomonadales prevalence
OTU97_1 (Bacteroides) prevalence
OTU97_100 (Ruminococcaceae) prevalence
OTU97_101 (Sutterella) prevalence
OTU97_102 (Prevotella) prevalence
OTU97_105 (Ruminococcaceae) prevalence
OTU97_106 (Ruminococcaceae) prevalence
OTU97_108 (Phascolarctobacterium) prevalence
OTU97_109 (Paraprevotella) prevalence
OTU97_11 (Parabacteroides) prevalence
OTU97_113 (Bacteroidales) prevalence
OTU97_117 (Ruminococcus) prevalence
OTU97_119 (Desulfovibrio) prevalence
OTU97_12 (Bacteroides) prevalence
OTU97_126 (Prevotella) prevalence
OTU97_13 (Subdoligranulum) prevalence
OTU97_130 (Butyrivibrio) prevalence
OTU97_137 (Catenibacterium) prevalence
OTU97_138 (Oscillibacter) prevalence
OTU97_140 (Bacteroides) prevalence
OTU99_30 (Parasutterella) prevalence
Peak weight velocity
7,215 European ancestry children
5,367 European ancestry children
Affymetrix, Illumina [up to 2543888] (imputed)
Age at adiposity peak
6,222 European ancestry children
BMI at adiposity peak
6,219 European ancestry children
16,550 European ancestry children
Age at adiposity rebound
6,051 European ancestry children
12,256 European ancestry children
BMI at adiposity rebound
12,192 European ancestry children
Peak height velocity
6,933 European ancestry children
OTU99_26 (Parasutterella) prevalence
OTU99_271 (Prevotella) prevalence
OTU99_298 (Phascolarctobacterium) prevalence
OTU99_3 (Bacteroides) prevalence
OTU99_32 (Prevotella) prevalence
OTU99_34 (Holdemanella) prevalence
OTU99_35 (Ruminococcus) prevalence
OTU99_39 (Alphaproteobacteria) prevalence
OTU99_4 (Alistipes) prevalence
OTU99_40 (Proteobacteria) prevalence
OTU99_45 (Faecalibacterium) prevalence
OTU99_47 (Prevotella) prevalence
OTU99_5 (Sutterella) prevalence
OTU99_53 (Aestuariispira) prevalence
OTU99_54 (Holdemanella) prevalence
OTU99_55 (Barnesiella) prevalence
OTU99_558 (Bacteroidales) prevalence
OTU99_58 (Bacteroides) prevalence
OTU99_59 (Prevotella) prevalence
OTU99_6 (Sutterella) prevalence
OTU99_62 (Ruminococcaceae) prevalence
OTU99_65 (Sutterellaceae) prevalence
OTU99_7 (Lachnospiraceae) prevalence
OTU99_72 (Parabacteroides) prevalence
OTU99_78 (Clostridiales) prevalence
TestASV_47 (Parasutterella) abundance
TestASV_48 (Sutterella) abundance
TestASV_49 (Parasutterella) abundance
TestASV_5 (Bacteroides) abundance
TestASV_6 (Subdoligranulum) abundance
TestASV_7 (Bacteroides) abundance
TestASV_8 (Bacteroides) abundance
TestASV_9 (Alistipes) abundance
C_Alphaproteobacteria prevalence
C_Negativicutes prevalence
F_Acidaminococcaceae prevalence
F_Prevotellaceae prevalence
G_Alloprevotella prevalence
G_Alphaproteobacteria prevalence
G_Bacteroidales prevalence
G_Bacteroidetes prevalence
G_Barnesiella prevalence
G_Catenibacterium prevalence
G_Coprococcus prevalence
G_Holdemanella prevalence
G_Parabacteroides prevalence
G_Paraprevotella prevalence
G_Parasutterella prevalence
G_Phascolarctobacterium prevalence
G_Porphyromonadaceae prevalence
OTU97_4 (Alistipes) prevalence
OTU97_46 (Lachnospiraceae) prevalence
OTU97_5 (Sutterella) prevalence
OTU97_50 (Aestuariispira) prevalence
OTU97_51 (Barnesiella) prevalence
OTU97_53 (Bacteroides) prevalence
OTU97_56 (Ruminococcaceae) prevalence
OTU97_58 (Sutterellaceae) prevalence
OTU97_6 (Sutterella) prevalence
OTU97_65 (Parabacteroides) prevalence
OTU97_69 (Clostridiales) prevalence
OTU97_7 (Lachnospiraceae) prevalence
OTU97_73 (Prevotella) prevalence
OTU97_74 (Alistipes) prevalence
OTU97_8 (Ruminococcaceae) prevalence
OTU97_80 (Ruminococcus) prevalence
OTU97_82 (Bacteroides) prevalence
OTU97_86 (Phascolarctobacterium) prevalence
OTU97_9 (Alistipes) prevalence
OTU97_95 (Cytophagales) prevalence
OTU97_97 (Clostridiales) prevalence
OTU99_1 (Bacteroides) prevalence
OTU99_106 (Barnesiella) prevalence
OTU99_108 (Cytophagales) prevalence
OTU99_11 (Parabacteroides) prevalence
OTU99_110 (Clostridiales) prevalence
OTU99_116 (Sutterella) prevalence
OTU99_12 (Bacteroides) prevalence
OTU99_120 (Ruminococcaceae) prevalence
OTU99_121 (Ruminococcaceae) prevalence
OTU99_123 (Phascolarctobacterium) prevalence
OTU99_124 (Paraprevotella) prevalence
OTU99_13 (Subdoligranulum) prevalence
OTU99_132 (Bacteroidales) prevalence
OTU99_137 (Ruminococcus) prevalence
OTU99_140 (Desulfovibrio) prevalence
OTU99_150 (Prevotella) prevalence
OTU99_155 (Butyrivibrio) prevalence
OTU99_157 (Barnesiella) prevalence
OTU99_16 (Faecalibacterium) prevalence
OTU99_166 (Prevotella) prevalence
OTU99_17 (Parabacteroides) prevalence
OTU99_171 (Bacteroides) prevalence
OTU99_19 (Bacteria) prevalence
OTU99_197 (Bacteroides) prevalence
OTU99_2 (Bacteroides) prevalence
OTU99_21 (Parasutterella) prevalence
OTU99_211 (Bacteroides) prevalence
OTU99_23 (Faecalibacterium) prevalence
OTU99_24 (Prevotella) prevalence
OTU97_15 (Parasutterella) prevalence
OTU97_150 (Bacteroides) prevalence
OTU97_16 (Faecalibacterium) prevalence
OTU97_163 (Bacteroides) prevalence
OTU97_165 (Porphyromonadaceae) prevalence
OTU97_17 (Parabacteroides) prevalence
OTU97_173 (Bacteroides) prevalence
OTU97_19 (Bacteria) prevalence
OTU97_2 (Bacteroides) prevalence
OTU97_21 (Parasutterella) prevalence
OTU97_23 (Faecalibacterium) prevalence
OTU97_235 (Phascolarctobacterium) prevalence
OTU97_24 (Prevotella) prevalence
OTU97_257 (Mitsuokella) prevalence
OTU97_26 (Parasutterella) prevalence
OTU97_27 (Bacteroides) prevalence
OTU97_277 (Prevotella) prevalence
OTU97_3 (Bacteroides) prevalence
OTU97_30 (Roseburia) prevalence
OTU97_31 (Prevotella) prevalence
OTU97_33 (Holdemanella) prevalence
OTU97_34 (Ruminococcus) prevalence
OTU97_354 (Alloprevotella) prevalence
OTU97_38 (Alphaproteobacteria) prevalence
OTU97_39 (Proteobacteria) prevalence
TestASV_23 (Barnesiella) abundance
TestASV_24 (Bacteroides) abundance
TestASV_25 (Sutterella) abundance
TestASV_26 (Phascolarctobacterium) abundance
TestASV_27 (Ruminococcaceae) abundance
TestASV_28 (Holdemanella) abundance
TestASV_29 (Barnesiella) abundance
TestASV_3 (Bacteroides) abundance
TestASV_30 (Paraprevotella) abundance
TestASV_31 (Ruminococcus) abundance
TestASV_32 (Ruminococcaceae) abundance
TestASV_33 (Paraprevotella) abundance
TestASV_34 (Phascolarctobacterium) abundance
TestASV_35 (Alphaproteobacteria) abundance
TestASV_36 (Aestuariispira) abundance
TestASV_37 (Ruminococcaceae) abundance
TestASV_38 (Ruminococcus) abundance
TestASV_39 (Bacteroides) abundance
TestASV_4 (Alistipes) abundance
TestASV_41 (Barnesiella) abundance
TestASV_42 (Alphaproteobacteria) abundance
TestASV_43 (Parasutterella) abundance
TestASV_44 (Parasutterella) abundance
TestASV_45 (Clostridiales) abundance
TestASV_46 (Sutterella) abundance
214 Chilean cases, 193 Chilean controls
Urinary metabolite modules (eigenmetabolites) in chronic kidney disease
1,221 cases
406 cases
Urinary metabolite levels in chronic kidney disease
281 African American individuals from 73 families, 516 European American individuals from 75 families, 125 East Asian ancestry individuals from 15 families, 598 Mexican American individuals from 96 families
TPE interval (resting)
71,338 European ancestry individuals
TPE interval (response to exercise)
51,897 European ancestry individuals
TPE interval (recovery after exercise)
51,503 European ancestry individuals
Bipolar disorder or body mass index
20,352 European ancestry bipolar disorder cases, 31,358 European ancestry controls, 322,154 European ancestry individuals with BMI data.
Genome-wide genotyping array, Targeted genotyping array
Bipolar disorder or type 2 diabetes
20,352 European ancestry bipolar disorder cases, 26,676 European ancestry type 2 diabetes cases, 163,890 European ancestry controls
47,309 European ancestry cases, 930,014 European ancestry controls
Affymetrix, Illumina [8246881] (imputed)
Brain imaging measurements (variance)
25,575 European ancestry individuals
Brain imaging measurements (mean)
Childhood maltreatment
124,711 European ancestry individuals
26,290 European ancestry individuals
Affymetrix, Illumina [at least 800000] (imputed)
Membranous nephropathy
2,150 European ancestry cases, 5,829 European ancestry controls, 1,612 East Asian ancestry cases, 1,970 East Asian ancestry controls
826 Chinese ancestry cases, 1,239 Chinese ancestry controls
2,150 European ancestry cases, 5,829 European ancestry controls
1,612 East Asian ancestry cases, 1,970 East Asian ancestry controls
Hallux valgus
609 European ancestry male cases, 1,666 European ancestry male controls
Affymetrix, Illumina [up to 7729175] (imputed)
1,705 European ancestry female cases, 1,945 European ancestry female controls
2,314 European ancestry cases, 3,611 European ancestry controls
Multiple traits (2,148)
46,191 European ancestry individuals
Multiple traits (2,173)
456,422 European ancestry individuals
Externalizing behaviour score
7,568 European ancestry individuals, 3,274 African ancestry individuals, 4,270 European and African ancestry individuals
Affymetrix, Illumina [up to 15537641] (imputed)
Substance uses or psychiatric disorders (pleiotropy)
Up to 1,232,09 European ancestry individuals with substance use, 53,293 European ancestry ADHD cases, 72,517 European ancestry anorexia cases, 51,710 European ancestry bipolar disorder cases, 173,005 European ancestry major depressive disorder cases, 105,318 European ancestry schizophrenia cases, 1,475,951 European ancestry controls
Smoking initiation (ever regular vs never regular)
83,830 Japanese ancestry ever smokers, 81,626 Japanese ancestry never smokers
67,773 Japanese ancestry ever smoker males, 21,905 Japanese ancestry never smoker males
16,077 Japanese ancestry ever smoker females, 59,721 Japanese ancestry never smoker females
Smoking cessation (former vs current smokers)
43,163 Japanese ancestry former smokers, 32,884 Japanese ancestry current smokers
36,787 Japanese ancestry former smoker males, 24,909 Japanese ancestry current smoker males
6,376 Japanese ancestry former smoker females, 7,975 Japanese ancestry current smoker females
72,655 Japanese ancestry individuals
13,871 Japanese ancestry females
58,784 Japanese ancestry males
Age of smoking initiation
30,418 Japanese ancestry individuals
7,379 Japanese ancestry females
23,039 Japanese ancestry males
Survival in breast cancer (estrogen-receptor positive)
953 Taiwanese individuals
White matter hyperintensity volume
350 European ancestry elderly individuals
Cardioembolic stroke (CCSp classification)
3,608 European and African ancestry cases, 28,026 European and unknown ancestry controls
Cardioembolic stroke (TOAST classification)
3,333 European and African ancestry cases, 28,026 European and unknown ancestry controls
Cardioembolic stroke (CCS and TOAST classification)
2,219 European and African ancestry cases, 28,026 European and unknown ancestry controls
Cardioembolic stroke (CCS or TOAST classification)
4,502 European and African ancestry cases, 28,026 European and unknown ancestry controls
Large artery stroke (CCSc classification)
1,565 European and African ancestry cases, 28,026 European and unknown ancestry controls
Large artery stroke (CCSp classification)j
2,449 European and African ancestry cases, 28,026 European and unknown ancestry controls
Large artery stroke (TOAST classification)
2,318 European and African ancestry cases, 28,026 European and unknown ancestry controls
Large artery stroke (CCS and TOAST classification)
1,328 European and African ancestry cases, 28,026 European and unknown ancestry controls
Large artery stroke (CCS or TOAST classification)
3,495 European and African ancestry cases, 28,026 European and unknown ancestry controls
Small vessel stroke (CCSc classification)
2,262 European and African ancestry cases, 28,026 European and unknown ancestry controls
Small vessel stroke (CCSp classification)
2,419 European and African ancestry cases, 28,026 European and unknown ancestry controls
Small vessel stroke (TOAST classification)
2,631 European and African ancestry cases, 28,026 European and unknown ancestry controls
Small vessel stroke (CCS and TOAST classification)
1,548 European and African ancestry cases, 28,026 European and unknown ancestry controls
Small vessel stroke (CCS or TOAST classification)
3,480 European and African ancestry cases, 28,026 European and unknown ancestry controls
Cardioembolic stroke (CCSc classification)
3,000 European and African ancestry cases, 28,026 European and unknown ancestry controls
Gastrointestinal infection
7,197 Danish ancestry cases, 37,062 Danish ancestry controls
Gout
3,053 Japanese ancestry male cases, 4,554 Japanese ancestry male controls
Renal underexcretion gout
654 Japanese ancestry male cases, 4,554 Japanese ancestry male controls
Renal overload gout
486 Japanese ancestry male cases, 4,554 Japanese ancestry male controls
Gout (combined type)
905 Japanese ancestry male cases, 4,554 Japanese ancestry male controls
Gout (normal type)
92 Japanese ancestry male cases, 4,554 Japanese ancestry male controls
6,254 European ancestry individuals
6,253 European ancestry individuals
Diastolic blood pressure x quantitative lifestyle risk score interaction (1df test)
Diastolic blood pressure x quantitative lifestyle risk score interaction (2df test)
Diastolic blood pressure x dichotomous lifestyle risk score interaction (1df test)
1,924 European ancestry unexposed individuals, 4,330 European ancestry exposed individuals
Diastolic blood pressure x dichotomous lifestyle risk score interaction (2df test)
Systolic blood pressure x quantitative lifestyle risk score interaction (1df test)
Systolic blood pressure x quantitative lifestyle risk score interaction (2df test)
Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test)
Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test)
HDL cholesterol levels x smoking (current vs non smokers) interaction (2df test)
HDL cholesterol levels in current smokers
5,120 African ancestry individuals, 2,394 Asian ancestry individuals, 15,129 European ancestry individuals, 747 Hispanic individuals
HDL cholesterol levels in non smokers
18,641 African ancestry individuals, 10,777 Asian ancestry individuals, 75,138 European ancestry individuals, 5,873 Hispanic individuals
HDL cholesterol levels x smoking (ever vs never smokers) interaction (1df test)
11,893 African ancestry ever smoker individuals, 4,025 Asian ancestry ever smoker individuals, 49,475 European ancestry ever smoker individuals, 2,544 Hispanic ever smoker individuals, 11,866 African ancestry never smoker individuals, 9,146 Asian ancestry never smoker individuals, 40,797 European ancestry never smoker individuals, 4,076 Hispanic never smoker individuals
2,827 African ancestry ever smoker individuals, 37,952 Asian ancestry ever smoker individuals, 82,808 European ancestry ever smoker individuals, 7,091 Hispanic ever smoker individuals, 2,785 African ancestry never smoker individuals, 43,565 Asian ancestry never smoker individuals, 64,252 European ancestry never smoker individuals, 10,431 Hispanic never smoker individuals
HDL cholesterol levels x smoking (ever vs never smokers) interaction (2df test)
HDL cholesterol levels in ever smokers
11,893 African ancestry individuals, 4,025 Asian ancestry individuals, 49,475 European ancestry individuals, 2,544 Hispanic individuals
HDL cholesterol levels in never smokers
11,866 African ancestry individuals, 9,146 Asian ancestry individuals, 40,797 European ancestry individuals, 4,076 Hispanic individuals
up to 23,761 African ancestry individuals, 13,171 Asian ancestry individuals, up to 90,272 European ancestry individuals, 6,620 Hispanic individuals
LDL cholesterol levels x smoking (current vs non smokers) interaction (1df test)
4,973 African ancestry current smoker individuals, 2,375 Asian ancestry current smoker individuals, 13,799 European ancestry current smoker individuals, 755 Hispanic current smoker individuals, 18,384 African ancestry non smoker individuals, 10,742 Asian ancestry non smoker individuals, 68,719 European ancestry non smoker individuals, 5,894 Hispanic non smoker individuals
1,357 African ancestry current smoker individuals, 8,901 Asian ancestry current smoker individuals, 25,008 European ancestry current smoker individuals, 3,441 Hispanic current smoker individuals, 3,967 African ancestry non smoker individuals, 39,448 Asian ancestry non smoker individuals, 92,432 European ancestry non smoker individuals, 13,555 Hispanic non smoker individuals
LDL cholesterol levels x smoking (current vs non smokers) interaction (2df test)
LDL cholesterol levels in current smokers
4,973 African ancestry individuals, 2,375 Asian ancestry individuals, 13,799 European ancestry individuals, 755 Hispanic individuals
LDL cholesterol levels in non smokers
18,384 African ancestry individuals, 10,742 Asian ancestry individuals, 68,719 European ancestry individuals, 5,894 Hispanic individuals
LDL cholesterol levels x smoking (ever vs never smokers) interaction (1df test)
11,649 African ancestry ever smoker individuals, 3,999 Asian ancestry ever smoker individuals, 45,506 European ancestry ever smoker individuals, 2,554 Hispanic ever smoker individuals, 11,700 African ancestry never smoker individuals, 9,118 Asian ancestry never smoker individuals, 37,016 European ancestry never smoker individuals, 4,095 Hispanic never smoker individuals
1,693 African ancestry ever smoker individuals, 20,368 Asian ancestry ever smoker individuals, 65,806 European ancestry ever smoker individuals, 6,857 Hispanic ever smoker individuals, 2,025 African ancestry never smoker individuals, 27,981 Asian ancestry never smoker individuals, 51,361 European ancestry never smoker individuals, 10,139 Hispanic never smoker individuals
LDL cholesterol levels x smoking (ever vs never smokers) interaction (2df test)
LDL cholesterol levels in ever smokers
11,649 African ancestry individuals, 3,999 Asian ancestry individuals, 45,506 European ancestry individuals, 2,554 Hispanic individuals
LDL cholesterol levels in never smokers
11,700 African ancestry individuals, 9,118 Asian ancestry individuals, 37,016 European ancestry individuals, 4,095 Hispanic individuals
up to 23,353 African ancestry individuals, 13,171 Asian ancestry individuals, up to 82,522 European ancestry individuals, 6,646 Hispanic individuals
Triglyceride levels x smoking (current vs non smokers) interaction (1df test)
5,022 African ancestry current smoker individuals, 808 Asian ancestry current smoker individuals, 13,303 European ancestry current smoker individuals, 764 Hispanic current smoker individuals, 18,489 African ancestry non smoker individuals, 3,841 Asian ancestry non smoker individuals, 63,740 European ancestry non smoker individuals, 5,941 Hispanic non smoker individuals
1,367 African ancestry current smoker individuals, 22,744 Asian ancestry current smoker individuals, 22,268 European ancestry current smoker individuals, 2,899 Hispanic current smoker individuals, 3,989 African ancestry non smoker individuals, 89,177 Asian ancestry non smoker individuals, 86,885 European ancestry non smoker individuals, 11,811 Hispanic non smoker individuals
Triglyceride levels x smoking (current vs non smokers) interaction (2df test)
Triglyceride levels in current smokers
5,022 African ancestry individuals, 808 Asian ancestry individuals, 13,303 European ancestry individuals, 764 Hispanic individuals
Triglyceride levels in non smokers
18,489 African ancestry individuals, 3,841 Asian ancestry individuals, 63,740 European ancestry individuals, 5,941 Hispanic individuals
Triglyceride levels x smoking (ever vs never smokers) interaction (2df test)
11,735 African ancestry ever smoker individuals, 1,172 Asian ancestry ever smoker individuals, 42,899 European ancestry ever smoker individuals, 2,582 Hispanic ever smoker individuals, 11,777 African ancestry never smoker individuals, 3,477 Asian ancestry never smoker individuals, 34,148 European ancestry never smoker individuals, 4,123 Hispanic never smoker individuals
1,710 African ancestry ever smoker individuals, 54,217 Asian ancestry ever smoker individuals, 11,550 European ancestry ever smoker individuals, 5,915 Hispanic ever smoker individuals, 2,040 African ancestry never smoker individuals, 57,704 Asian ancestry never smoker individuals, 47,916 European ancestry never smoker individuals, 8,795 Hispanic never smoker individuals
Triglyceride levels x smoking (ever vs never smokers) interaction (1df test)
1,710 African ancestry ever smoker individuals, 54,217 Asian ancestry ever smoker individuals, 11,550 European ancestry ever smoker individuals, 5,915 Hispanic ever smoker individuals, 2,040 African ancestry never smoker individuals, 57,704 Asian ancestry never smoker individuals, 60,675 European ancestry never smoker individuals, 8,795 Hispanic never smoker individuals
Triglyceride levels in ever smokers
11,735 African ancestry individuals, 1,172 Asian ancestry individuals, 42,899 European ancestry individuals, 2,582 Hispanic individuals
Triglyceride levels in never smokers
11,777 African ancestry individuals, 3,477 Asian ancestry individuals, 34,148 European ancestry individuals, 4,123 Hispanic individuals
1,362 Korean ancestry cases, 6,061 Korean ancestry controls
Hypertriglyceridemia
7,423 Korean ancestry cases and controls
Low HDL-cholesterol levels
High fasting blood glucose
502 Korean ancestry cases, 1,751 Korean ancestry controls
2,253 Korean ancestry cases and controls
Hematological and biochemical traits
up to 6,843 Korean ancestry individuals
Lung function
up to 4,291 Korean ancestry individuals
Cholesterol
6,840 Korean ancestry individuals
Physiological traits
up to 6,835 Korean ancestry individuals
1,076 Peruvian cases, 2,328 Peruvian controls
Post-traumatic stress disorder
1,698 Peruvian cases, 1,716 Peruvian controls
Suicidal or self-harm ideation
522 Peruvian cases, 2,882 Peruvian controls
14,735 African American individuals, 6,762 African ancestry individuals, 21,684 Hispanic/Latino individuals
7,050 African American individuals
Affymetrix, Illumina [up to 35800000] (imputed)
14,739 African American individuals, 6,762 African ancestry individuals, 21,686 Hispanic/Latino individuals
7,037 African American individuals
14,743 African American individuals, 6,762 African ancestry individuals, 21,034 Hispanic/Latino individuals
6,743 African American individuals
Adult onset Still's disease
70 Han Chinese ancestry cases, 688 Han Chinese ancestry controls
36 Han Chinese ancestry cases, 200 Han Chinese ancestry controls
Parkinson's disease (age of onset)
3,997 Spanish ancestry individuals
4,639 Spanish ancestry cases, 2,949 Spanish ancestry controls
up to 6,407 African ancestry individuals
Affymetrix, Illumina [at least 20594556] (imputed)
Neck pain or shoulder pain
53,994 European ancestry cases, 149,312 European ancestry controls
5,035 cases, 18,545 controls
Parkinson's disease or first degree relation to individual with Parkinson's disease
15,056 European ancestry cases, 18,618 European ancestry proxy cases, 449,056 European ancestry controls
22,632 European ancestry cases, 968,735 European ancestry controls
15,056 European ancestry cases, 12,637 European ancestry controls
29,435 European ancestry cases, 157,769 European ancestry controls
Affymetrix, Illumina [12923718] (imputed)
799 African American cases, 14,353 African American controls
29,435 European ancestry cases, 799 African American cases, 157,769 European ancestry controls, 14,353 African American controls
Early progression to active pulmonary tuberculosis in Mycobacterium tuberculosis-infected individuals
2,160 Peruvian cases, 1,820 Peruvian controls
Panic disorder
2,147 European ancestry cases, 7,760 European ancestry controls
2,408 European ancestry cases, 228,470 European ancestry controls
Adventurousness
557,923 European ancestry individuals
Automobile speeding propensity
404,291 European ancestry individuals
Alcohol consumption (drinks per week)
414,343 European ancestry individuals
518,633 European ancestry individuals
Number of sexual partners
370,711 European ancestry individuals
General risk tolerance (MTAG)
975,353 European ancestry individuals
Affymetrix, Illumina [5869552] (imputed)
Risk-taking tendency (4-domain principal component model)
315,894 European ancestry individuals
General risk tolerance
939,908 European ancestry individuals
35,445 European ancestry individuals
Affymetrix, Illumina [9284738] (imputed)
Severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis
42 European ancestry cases, 1,052 European ancestry controls
Moderate or severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis
206 European ancestry cases, 1,052 European ancestry controls
Decreased low contrast letter acuity in multiple sclerosis
582 European and unknown ancestry individuals
253 European and unknown ancestry individuals
Rate of retinal ganglion cell–inner plexiform layer atrophy in multiple sclerosis
374 European and unknown ancestry individuals
376 individuals
Cortical surface area (visual PC2)
23,784 European ancestry individuals
19,512 European ancestry individuals, 6,234 individuals
Cortical thickness (PC1)
Cortical thickness (PC2)
Cortical surface area (global PC1)
159,095 Japanese ancestry individuals
32,692 Japanese ancestry individuals
Circulating leptin levels or fasting insulin levels
254,263 individuals
Circulating leptin levels or HOMA-B
Circulating leptin levels or HOMA-IR
Circulating leptin levels or type 2 diabetes
2,231 Japanese ancestry men
2,599 Japanese ancestry men
2,431 Japanese ancestry women
3,109 Japanese ancestry women
50,409 European ancestry cases, 523,897 European ancestry controls
Affymetrix, Illumina [~ 27000000] (imputed)
74,124 European ancestry cases, 824,006 European ancestry controls
Occipital lobe volume
15,269 European ancestry individuals
8,789 European ancestry individuals
Parietal lobe volume
Temporal lobe volume
15,269 European ancestry individuals, 405 African American individuals, 211 Chinese ancestry individuals, 131 Malay ancestry individuals
Frontal lobe volume
Skin pigmentation (conditioned on rs1426654 and rs35397)
1,047 Hispanic/Latin American individuals, 684 Cape Verdian individuals, 373 African American individuals
Affymetrix, Illumina [at least 292549] (imputed)
762 Cuban ancestry individuals
East African ancestry individuals (See Crawford et. al, 2017)
B-cell acute lymphoblastic leukaemia
5,321 European ancestry cases, 16,666 European ancestry controls
2,237 cases, 3,461 controls
Affymetrix, Illumina [~ 6118121] (imputed)
B-cell acute lymphoblastic leukaemia (high-hyperdiploidy)
1,369 European ancestry cases, 16,666 European ancestry controls
422 cases, 3,461 controls
B-cell acute lymphoblastic leukaemia (ETV6-RUNX1 positive)
936 European ancestry cases, 16,666 European ancestry controls
365 cases, 3,461 controls
Hospital contact for infections
21,728 Danish ancestry cases with psychiatric disorders, 6,744 Danish ancestry cases, 24,161 Danish ancestry controls with psychiatric disorders, 12,901 Danish ancestry controls
Disability (impaired activities of daily living)
7,544 European ancestry cases, 4,619 European ancestry controls
5,006 European ancestry cases, 6,899 European ancestry controls
Circulating leptin levels in high cardiovascular risk
351 Spanish mediterranean ancestry men, 615 Spanish mediterranean ancestry women
Circulating leptin levels x sex interaction in high cardiovascular risk
317 Greenlandic ancestry cases, 2,631 Greenlandic ancestry controls
Serum sclerostin levels
10,584 European ancestry individuals
2,893 British ancestry cases, 360,233 British ancestry controls
Affymetrix, Illumina [7701827] (imputed)
Retinal detachment or retinal break
3,977 British ancestry cases, 360,233 British ancestry controls
Retinal detachment with retinal break
1,380 British ancestry cases, 360,233 British ancestry controls
6,141 European ancestry cases, 59,475 European ancestry controls
9,171 European ancestry cases, 406,168 European ancestry controls
Affymetrix, Illumina [7581674] (imputed)
2,737 British ancestry cases, 47,635 British ancestry controls
Cataracts (operation)
21,679 British ancestry cases, 387,283 British ancestry controls
3,267 European ancestry individuals, 1,619 Chinese ancestry individuals, 843 African American individuals, 446 Hispanic individuals
Hip bone size
Bone mineral density (hip) and hip bone size
404,588 European ancestry individuals, 17,651 European, Hispanic and African ancestry individuals
542,934 European ancestry individuals
351,091 European ancestry individuals
1,644 African American cases, 1,727 African American controls
852 Europen ancestry cases, 720 European ancestry controls
261 Chinese ancestry cases
525 Chinese ancestry cases
Birth weight (MTAG)
up to 182,902 European ancestry individuals
Birth length (MTAG)
Infant head circumference (MTAG)
Urinary incontinence
6,120 European ancestry female cases, 4,811 European ancestry female controls
Affymetrix, Illumina [1410640] (imputed)
Stress urinary incontinence
1,809 European ancestry female cases, 4,811 European ancestry female controls
Urgency urinary incontinence
1,942 European ancestry female cases, 4,811 European ancestry female controls
Stress urinary incontinence and urgency urinary incontinence
2,036 European ancestry female cases, 4,811 European ancestry female controls
Fecal incontinence
4,247 European ancestry female cases, 11,634 European ancestry female controls
Facial morphology
10,115 European ancestry individuals
Impaired insulin sensitivity in response to n-3 PUFA supplementation
32 French Canadian ancestry cases, 106 French Canadian ancestry controls
Cerebrospinal fluid sTREM-2 levels
224 healthy normal individuals, 72 significant memory concern individuals, 234 early mild cognitive impairment individuals, 277 late mild cognitive impairment individuals, 194 Alzheimer's disease cases
up to 653 individuals
up to 317 individuals
C-X-C motif chemokine 10 levels
CCL24 levels
MHC class I polypeptide-related sequence A levels
kallikrein-11 levels
interleukin 17 receptor B levels
interleukin 12 receptor subunit beta-1 levels
melanoma-derived growth regulatory protein levels
LDL cholesterol levels x loop diuretics use interaction
2,117 European ancestry exposed individuals, 30,715 European ancestry unexposed individuals, 784 African American and African ancestry exposed individuals, 5,218 African American and African ancestry unexposed individuals
Triglyceride levels x loop diuretics use interaction
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction
6,878 European ancestry exposed individuals, 30,715 European ancestry unexposed individuals, 3,923 African American and African ancestry exposed individuals, 5,218 African American and African ancestry unexposed individuals
LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction
Triglyceride levels x thiazide or thiazide-like diuretics use interaction
HDL cholesterol levels x loop diuretics use interaction
Exfoliation syndrome
132 Georgian ancestry cases, 199 Georgian ancestry controls
Lung function in heavy smokers (low FEV1 vs high FEV1)
9,748 European ancestry individuals with low FEV1 measurements, 4,906 European ancestry individuals with high FEV1 measurements
Lung function in never smokers (high FEV1 vs average FEV1)
4,902 European ancestry individuals with high FEV1 measurements, 9,827 European ancestry individuals with average FEV1 measurements
Lung function in heavy smokers (high FEV1 vs average FEV1)
4,906 European ancestry individuals with high FEV1 measurements, 9,803 European ancestry individuals with average FEV1 measurements
Lung function in never smokers (low FEV1 vs average FEV1)
9,745 European ancestry individuals with low FEV1 measurements, 9,827 European ancestry individuals with average FEV1 measurements
Lung function in heavy smokers (low FEV1 vs average FEV1)
9,748 European ancestry individuals with low FEV1 measurements, 9,803 European ancestry individuals with average FEV1 measurements
Smoking status (heavy vs never)
24,457 European ancestry heavy smokers, 24,474 European ancestry never smokers
Lung function (low FEV1 vs high FEV1) x smoking interaction
9,745 European ancestry never smokers with low FEV1 measurements, 4,902 European ancestry never smokers with high FEV1 measurements, 9,748 European ancestry heavy smokers with low FEV1 measurements, 4,906 European ancestry heavy smokers with high FEV1 measurements
Lung function (low FEV1 vs high FEV1)
19,493 European ancestry individuals with low FEV1 measurements, 9,808 European ancestry individuals with high FEV1 measurements
Lung function in never smokers (low FEV1 vs high FEV1)
9,745 European ancestry individuals with low FEV1 measurements, 4,902 European ancestry individuals with high FEV1 measurements
Diabetic retinopathy (all NPDR and PDR)
1,079 European ancestry cases, 1,970 European ancestry controls, 911 African American cases, 941 African American controls
7,178 East Asian ancestry cases, 6,525 East Asian ancestry controls, 214 South East Asian ancestry cases, 557 South East Asian ancestry controls, 315 South Asian ancestry cases, 669 South Asian ancestry controls, 8,205 European ancestry cases, 7,713 European ancestry controls, 1,470 Hispanic cases, 1,240 Hispanic controls
Proliferative diabetic retinopathy (vs NPDR and no DR)
398 European ancestry cases, 2,848 European ancestry controls, 1,097 African American cases, 1,514 African American controls
918 East Asian ancestry cases, 1,167 East Asian ancestry controls, 2,038 European ancestry cases, 6,783 European ancestry controls, 232 Hispanic cases, 2,194 Hispanic controls
Diabetic retinopathy (moderate NPDR and PDR)
644 European ancestry cases, 1,970 European ancestry controls, 768 African American cases, 941 African American controls
2,388 East Asian ancestry cases, 6,219 East Asian ancestry controls, 1,658 European ancestry cases, 3,019 European ancestry controls, 1,014 Hispanic cases, 1,240 Hispanic controls
Proliferative diabetic retinopathy (vs no DR)
398 European ancestry cases, 1,970 European ancestry controls, 1,097 African American cases, 941 African American controls
1,354 East Asian ancestry cases, 1130 East Asian ancestry controls, 801 European ancestry cases, 2,880 European ancestry controls, 232 Hispanic cases, 1,048 Hispanic controls
Kidney stones
6,536 British ancestry cases, 388,508 British ancestry controls
6,536 British ancestry cases, 5,587 Japanese ancestry cases, 388,508 British ancestry controls, 28,870 Japanese ancestry controls
365,998 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals
299,024 European ancestry individuals, 17,277 individuals
Pulse pressure
225,112 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals
445,360 individuals
324,708 British ancestry individuals
324,694 British ancestry individuals
205,327 European ancestry males
Hippocampal atrophy rate
602 European ancestry elderly individuals
HDL cholesterol levels x long total sleep time interaction (2df test)
2,933 African American long sleepers, 364 Chinese ancestry long sleepers, 112 Asian ancestry long sleepers, up to 7,870 European ancestry long sleepers, 1,038 Hispanic/Latino long sleepers, up to 11,975 African American controls, 1,449 Chinese ancestry controls, 454 Asian ancestry controls, at least 32,171 European ancestry controls, 4,091 Hispanic/Latino controls
at least 217 African American long sleepers, 616 East Asian ancestry long sleepers, up to 9,486 European ancestry long sleepers, 2,515 Hispanic long sleepers, at least 929 African American controls, 2,517 East Asian ancestry controls, up to 38,126 European ancestry controls, 10,063 Hispanic controls
Affymetrix, Illumina [up to 2533153] (imputed)
Triglyceride levels x long total sleep time interaction (1df test)
at least 2,926 African American long sleepers, 364 Chinese ancestry long sleepers, 112 Asian ancestry long sleepers, at least 7,664 European ancestry long sleepers, 1,038 Hispanic/Latino long sleepers, up to 11,906 African American controls, 1,449 Chinese ancestry controls, 454 Asian ancestry controls, at least 31,986 European ancestry controls, 4,091 Hispanic/Latino controls
at least 217 African American long sleepers, 317 East Asian ancestry long sleepers, up to 5,171 European ancestry long sleepers, 2,515 Hispanic long sleepers, at least 928 African American controls, 1,301 East Asian ancestry controls, up to 20,961 European ancestry controls, 10,064 Hispanic controls
HDL cholesterol levels x short total sleep time interaction (2df test)
3,007 African American short sleepers, 369 Chinese ancestry short sleepers, 114 Asian ancestry short sleepers, at least 8,474 European ancestry short sleepers, 1,082 Hispanic/Latino short sleepers, up to 11,901 African American controls, 1,444 Chinese ancestry controls, 452 Asian ancestry controls, at least 31,567 European ancestry controls, 4,047 Hispanic/Latino controls
up to 221 African American short sleepers, 629 East Asian ancestry short sleepers, up to 9,585 European ancestry short sleepers, 2,517 Hispanic short sleepers, at least 925 African American controls, 2,504 East Asian ancestry controls, up to 38,027 European ancestry controls, 10,061 Hispanic controls
LDL cholesterol levels x long total sleep time interaction (2df test)
2,913 African American long sleepers, 358 Chinese ancestry long sleepers, 110 Asian ancestry long sleepers, 7,583 European ancestry long sleepers, 1,036 Hispanic/Latino long sleepers, up to 11,862 African American controls, 1,432 Chinese ancestry controls, 444 Asian ancestry controls, at least 31,744 European ancestry controls, 4,066 Hispanic/Latino controls
at least 214 African American long sleepers, 616 East Asian ancestry long sleepers, up to 6,657 European ancestry long sleepers, 2,457 Hispanic long sleepers, at least 913 African American controls, 2,517 East Asian ancestry controls, up to 26,868 European ancestry controls, 9,870 Hispanic controls
LDL cholesterol levels x short total sleep time interaction (2df test)
2,974 African American short sleepers, 365 Chinese ancestry short sleepers, 110 Asian ancestry short sleepers, at least 8,230 European ancestry short sleepers, 1,079 Hispanic/Latino short sleepers, 11,801 African American controls, 1,425 Chinese ancestry controls, 444 Asian ancestry controls, at least 31,097 European ancestry controls, 4,023 Hispanic/Latino controls
at least 214 African American short sleepers, 629 East Asian ancestry short sleepers, up to 6,761 European ancestry short sleepers, 2,473 Hispanic short sleepers, at least 913 African American controls, 2,504 East Asian ancestry controls, up to 26,764 European ancestry controls, 9,854 Hispanic controls
Triglyceride levels x long total sleep time interaction (2df test)
Triglyceride levels x short total sleep time interaction (2df test)
2,990 African American short sleepers, 369 Chinese ancestry short sleepers, 114 Asian ancestry short sleepers, at least 8,300 European ancestry short sleepers, 1,082 Hispanic/Latino short sleepers, at least 11,842 African American controls, 1,444 Chinese ancestry controls, 452 Asian ancestry controls, at least 31,350 European ancestry controls, 4,047 Hispanic/Latino controls
at least 220 African American short sleepers, 326 East Asian ancestry short sleepers, up to 5,288 European ancestry short sleepers, 2,517 Hispanic short sleepers, at least 925 African American controls, 1,292 East Asian ancestry controls, up to 20,844 European ancestry controls, 10,062 Hispanic controls
HDL cholesterol levels x long total sleep time interaction (1df test)
14,832 African American individuals, 1,813 Chinese ancestry individuals, 566 Asian ancestry individuals, 39,650 European ancestry individuals, 5,129 Hispanic/Latino individuals
Triglyceride levels x short total sleep time interaction (1df test)
14,908 African American individuals, 1,813 Chinese ancestry individuals, 566 Asian ancestry individuals, 40,041 European ancestry individuals, 5,129 Hispanic/Latino individuals
HDL cholesterol levels x short total sleep time interaction (1df test)
LDL cholesterol levels x long total sleep time interaction (1df test)
14,775 African American individuals, 1,790 Chinese ancestry individuals, 554 Asian ancestry individuals, 39,327 European ancestry individuals, 5,102 Hispanic/Latino individuals
LDL cholesterol levels x short total sleep time interaction (1df test)
23,151 European ancestry cases, 553,439 European ancestry controls, 2,261 African American cases, 49,400 African American controls, 654 Hispanic cases, 21,214 Hispanic controls
17,672 cases, 167,295 controls
694 African American cases, 1,590 Sub-Saharan African cases, 596 African American controls, 1,485 Sub-Saharan African controls
6,937 African ancestry cases, 14,917 African ancestry controls
Two-hour insulin response
2,540 Greenlandic ancestry individuals
845 Greenlandic ancestry individuals
2,575 Greenlandic ancestry individuals
1,064 Greenlandic ancestry individuals
1,062 Greenlandic ancestry individuals
Two-hour glucose
Meat-related diet
154,123 European ancestry men, 181,453 European ancestry women
Pork consumption
335,576 European ancestry individuals
Poultry consumption
Raw vegetable consumption
Cooked vegetable consumption
Fruit consumption
Oily fish consumption
Non-oily fish consumption
Lamb consumption
Processed meat consumption
Fish- and plant-related diet
Beef consumption
Idiopathic pulmonary fibrosis
2,668 European ancestry cases, 8,591 European ancestry controls
1,456 European ancestry cases, 11,874 European ancestry controls
Affymetrix, Illumina [10790934] (imputed)
Brain age (difference between predicted and chronological age)
12,378 British ancestry individuals
4,456 British ancestry individuals
19,155 disease classifications in UK Biobank (pleiotropy)
320,644 British ancestry individuals
10,208 European ancestry individuals, 445 Hispanic individuals, 843 African ancestry individuals, 1,539 East Asian individuals
Affymetrix, Illumina [12061510] (imputed)
Trunk fat mass adjusted for trunk lean mass
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass
695 individuals
Nucleus accumbens volume
32,562 European ancestry individuals
341 South East and East Asian ancestry individuals, 85 African American individuals
Amygdala volume
34,431 European ancestry individuals
341 South East and East Asian ancestry individuals, 769 African American individuals
Brainstem volume
28,809 European ancestry individuals
Caudate nucleus volume
37,741 European ancestry individuals
Pallidum volume
34,413 European ancestry individuals
Putamen volume
37,571 European ancestry individuals
Thalamus volume
34,464 European ancestry individuals
Response to antiepileptic drugs in genetic generalized epilepsy
608 European ancestry responders, 278 European ancestry non-responders
Affymetrix, Illumina [at least 3287443] (imputed)
Response to valproic acid in genetic generalized epilepsy
410 European ancestry responders, 155 European ancestry non-responders
Response to lamotrigine in genetic generalized epilepsy
137 European ancestry responders, 250 European ancestry non-responders
Response to levetiracetam in genetic generalized epilepsy
82 European ancestry responders, 127 European ancestry non-responders
Response to lamotrigine and valproic acid in genetic generalized epilepsy
31 European ancestry responders, 73 European ancestry non-responders
Protein level change in low calorie diet obesity intervention
494 European ancestry individuals
Protein levels in obesity
6,724 East Asian ancestry cases, 24,851 East Asian ancestry controls
57,545 European ancestry cases, 1,868,816 European ancestry controls, 988 Japanese ancestry cases, 2,521 Japanese ancestry controls
Buruli ulcer
402 Sub-Saharan African ancestry cases, 401 Sub-Saharan African ancestry controls
455 Sub-Saharan African ancestry cases, 238 Sub-Saharan African ancestry controls
Buruli ulcer (age at onset)
402 Sub-Saharan African ancestry cases
455 Sub-Saharan African ancestry cases
Complement factor H binding to malondialdehyde
896 European ancestry major depressive disorder cases, 934 European ancestry individuals
934 European ancestry individuals
Cortical thickness
919 European ancestry individuals
Primary biliary cirrhosis
2,216 European ancestry cases, 5,594 Europen ancestry controls
Colorectal cancer x BMI interaction (2df)
14,059 European ancestry cases, 14,416 European ancestry controls
Affymetrix, Illumina [2700000] (imputed)
Death
5,974 European ancestry cases, up to 27,457 European ancestry controls
Affymetrix, Illumina [~ 2500000] (imputed)
up to 33,431 European ancestry individuals
Lung function (forced vital capacity)
Heart rate
883 European ancestry cases, up to 32,548 European ancestry controls
2,562 European ancestry cases, up to 30,869 European ancestry controls
4,935 European ancestry cases, up to 28,496 European ancestry controls
Coronary heart disease
6,403 European ancestry cases, up to 27,028 European ancestry controls
Diabetes mellitus
4,315 European ancestry cases, up to 29,116 European ancestry controls
3,527 European ancestry cases, up to 29,904 European ancestry controls
2,449 European ancestry cases, up to 30,982 European ancestry controls
Blood glucose levels
Non-small cell lung cancer in heavy smokers
47 European ancestry early age cases, 48 European ancestry advanced age controls
78 European ancestry early age cases, 55 European ancestry advanced age controls
Meningioma
1,606 European ancestry cases, 9,823 European ancestry controls
114 European ancestry cases, 406 European ancestry controls, 418 cases, 1,852 controls
Affymetrix, Illumina [up to 9213034] (imputed)
17,803 European ancestry individuals, 8,107 Asian ancestry individuals
17,803 European ancestry individuals
8,107 Asian ancestry individuals
8,694 African American individuals, 17,400 Hispanic or Latin American individuals, 14,693 European ancestry individuals, 127 Asian ancestry individuals, 20 Native American ancestry individuals, 382 individuals
Affymetrix, Illumina [21000000] (imputed)
8,694 African American individuals
14,693 European ancestry individuals
17,400 Hispanic or Latin American individuals
16,353 African American individuals, 20,877 Hispanic or Latin American individuals, 29,587 European ancestry individuals, 635 Asian ancestry individuals, 20 Native American ancestry individuals, 384 individuals
16,353 African American individuals
29,587 European ancestry individuals
20,877 Hispanic or Latin American individuals
8,556 African American individuals, 17,141 Hispanic or Latin American individuals, 14,483 European ancestry individuals, 125 Asian ancestry individuals, 594 Native American ancestry individuals, 377 individuals
8,556 African American individuals
14,483 European ancestry individuals
17,141 Hispanic or Latin American individuals
8,679 African American individuals, 17,412 Hispanic or Latin American individuals, 14,690 European ancestry individuals, 127 Asian ancestry individuals, 20 Native American ancestry individuals, 382 individuals
8,679 African American individuals
14,690 European ancestry individuals
17,412 Hispanic or Latin American individuals
6,141 African American individuals, 17,272 Hispanic or Latin American individuals, 9,611 European ancestry individuals, 123 Asian ancestry individuals, 20 Native American ancestry individuals, 382 individuals
6,141 African American individuals
9,611 European ancestry individuals
Red blood cell traits (multivariate analysis)
16,802 African American individuals
29,513 European ancestry individuals
20,697 Hispanic or Latin American individuals
16,184 African American individuals, 20,704 Hispanic or Latin American individuals, 29,383 European ancestry individuals, 631 Asian ancestry individuals, 601 Native American ancestry individuals, 381 individuals
16,184 African American individuals
29,383 European ancestry individuals
Chronic pain or major depressive disorder (pleiotropy)
10,543 European ancestry chronic pain cases, 43,028 major depressive disorder cases, 12,758 European ancestry controls, 87,522 controls
Lactose tolerance test
53 Fulani individuals, 7 Czech or Slovak individuals
Obstructive sleep apnea trait (apnea hypopnea index, change over time)
404 European ancestry individuals, 97 Black individuals, 20 Asian ancestry individuals, 20 Indigenous individuals, 138 mixed race individuals, 27 individuals
Opioid dependence x sex interaction
2,603 African American cases, 2,341 African American controls, 2,112 European ancestry cases, 1,331 European ancestry controls
Cognitive decline (age-related)
1,407 Brazilian ancestry individuals
Frontotemporal dementia (age at onset)
382 European ancestry GRN mutation carrier individuals
67 European ancestry GRN mutation carrier individuals, 143 European ancestry GRN negative individuals
Frontotemporal dementia with GRN mutation (age at onset)
382 European ancestry individuals
67 European ancestry individuals
Frontotemporal dementia
382 European ancestry GRN mutation carrier cases, 1,146 European ancestry controls
143 European ancestry GRN negative cases, 1,798 European ancestry controls
Memory dysfunction in frontotemporal lobe dementia
139 European ancestry cases, 243 European ancestry controls
Language impairment in frontotemporal lobe dementia
169 European ancestry cases, 213 European ancestry controls
Parkinsonism in frontotemporal lobe dementia
184 European ancestry cases, 198 European ancestry controls
67 GRN mutation carrier European ancestry cases, 143 GRN-negative European ancestry cases, 1,798 European ancestry controls
Behavioural changes in frontotemporal lobe dementia
262 European ancestry cases, 120 European ancestry controls
Frontotemporal dementia with GRN mutation
382 European ancestry cases, 1,146 European ancestry controls
67 European ancestry cases, 1,798 European ancestry controls
Optic disc size
28,509 European ancestry individuals
Hepatitis B surface antigen seroclearance in chronic hepatitis B infection
100 Korean ancestry cases, 100 Korean ancestry controls
Systolic blood pressure night-to-day ratio in hypertension
204 Finnish ancestry individuals
Diastolic blood pressure night-to-day ratio in hypertension
3,836 European ancestry cases, 48,065 European ancestry controls, 411 Hispanic cases, 4,778 Hispanic controls, 441 East Asian ancestry cases, 4,034 East Asian ancestry controls, 298 African American cases, 1,549 African American controls
6,687 European ancestry cases, 155,514 European ancestry controls, 204 South Asian ancestry cases, 4,916 South Asian ancestry controls, 272 African British cases, 4,831 African British controls, 22 East Asian ancestry cases, 873 East Asian ancestry controls, 144 mixed ancestry cases, 3,427 mixed ancestry controls
10,523 European ancestry cases, 203,579 European ancestry controls, 411 Hispanic cases, 4,778 Hispanic controls, 463 East Asian ancestry cases, 4,907 East Asian ancestry controls, 298 African American cases, 1,549 African American controls, 204 South Asian ancestry cases, 4,916 South Asian ancestry controls, 272 African British cases, 4,831 African British controls, 144 mixed ancestry cases, 3,427 mixed ancestry controls
Coronary artery disease in diabetes
3,968 British ancestry cases, 11,698 British ancestry controls
195 South Indian ancestry individuals from 15 families
1,520 Singaporean Indian individuals, 4,038 Mexican American individuals, 6,911 European ancestry individuals
4,038 Mexican American individuals, 4,806 European ancestry individuals
Cerebrospinal fluid α-synuclein levels
59 European ancestry individuals with normal cognition, 101 European ancestry individuals with mild cognitive impairment, 49 European ancestry Alzheimer's disease cases
Blood protein levels in cardiovascular risk
3,394 European ancestry individuals
2,639 individuals
Targeted genotyping array [Immunochip, Cardio-MetaboChip]
22,778 East Asian ancestry cases, 35,362 East Asian ancestry controls
Affymetrix, Illumina [9938587] (imputed)
22,778 East Asian ancestry cases, 35,362 East Asian ancestry controls, 33,640 European ancestry cases, 43,456 European ancestry controls
Affymetrix, Illumina [12447948] (imputed)
Cerebrospinal fluid neurofilament light levels
263 European ancestry individuals
Opioid use cessation
1,130 African American individuals, 2,919 European ancestry individuals
Alcohol consumption (heavy vs. light/non-drinkers)
21,967 British ancestry cases, 103,282 British ancestry controls
47,967 European ancestry individuals
199 Arabian ancestry cases, 253 Arabian ancestry controls
Basal ganglia growth
581 European ancestry individuals, 31 African American individuals, 8 Asian American individuals, 15 admixed individuals, 80 other ancestries individuals
White matter growth
581 European ancestry individuals, 31 African American individuals, 8 Asian American individuals 15 admixed individuals, 80 other ancestries individuals
Cerebellum growth
Cerebral cortical growth
Right lateral prefrontal cortical growth
Brain region volumes
21,821 European ancestry individuals
19,629 British ancestry individuals
Rosacea symptom severity
73,265 European ancestry individuals
Low tan response
46,768 European ancestry low tanning cases, 74,528 European ancestry moderate and high tanning controls
15,547 European ancestry low tanning cases, 39,835 European moderate and high tanning ancestry controls
Non-melanoma skin cancer
5,912 European ancestry cases, 181,740 European ancestry controls
Time to aseptic loosening in total joint arthroplasty
97 individuals
Aseptic loosening in total joint arthroplasty
97 cases, 289 controls
507 European ancestry cases, 61 Asian ancestry cases, 7 American ancestry cases, 2 Hispanic ancestry cases, 24 cases
7,064 Korean ancestry individuals
6,509 Korean ancestry individuals
Glomerular filtration rate
Uric acid levels
3,703 Korean ancestry individuals
Blood urea nitrogen levels
Inflammatory bowel disease
up to 20,155 European ancestry Crohn's disease cases, up to 15,191 European ancestry ulcerative colitis cases, up to 34,257 European ancestry controls
End stage renal disease x APOL1 genotype interaction
1,749 African American ESRD cases, 901 African American lupus nephritis-ESRD cases
End stage renal disease in APOL1 risk genotype-negative individuals
945 African American ESRD cases, 988 African American controls, 678 African American lupus nephritis-ESRD cases, 465 African American systemic lupus erythrematosus without nephropathy controls
End stage renal disease in APOL1 risk genotype-positive individuals
803 African American ESRD cases, 148 African American controls, 223 African American lupus nephritis-ESRD cases, 55 African American systemic lupus erythrematosus without nephropathy controls
1,749 African American ESRD cases, 1,136 African American controls, 901 African American lupus nephritis-ESRD cases, 520 African American systemic lupus erythrematosus without nephropathy controls
4,052 Hispanic cases and 4,606 Hispanic controls
2,071 Hispanic cases, 5,749 Hispanic controls, 1,519 Pima Indian ancestry cases, 1,680 Pima Indian ancestry controls, 427 Indigenous Mexican ancestry cases, 751 Indigenous Mexican ancestry controls.
71 Dutch ancestry cases, 169 Dutch ancestry controls
Optic cup area
24,493 European ancestry individuals
Affymetrix, Illumina [11830838] (imputed)
Optic disc area
24,509 European ancestry individuals
Affymetrix, Illumina [11764957] (imputed)
Vertical cup-disc ratio
25,180 European ancestry individuals
Affymetrix, Illumina [11901698] (imputed)
31,269 European ancestry individuals
Affymetrix, Illumina [12426120] (imputed)
16,204 European ancestry individuals
Affymetrix, Illumina [9249813] (imputed)
Optic nerve head parameters (multi-trait analysis)
up to 25,180 European ancestry individuals
up to 7,792 Chinese ancestry individuals, 3,280 Malay ancestry individuals, 3,400 Indian ancestry individuals
Affymetrix, Illumina [up to 11901698] (imputed)
Intraocular pressure and central corneal thickness (multi-trait analysis)
up to 31,269 European ancestry individuals
Affymetrix, Illumina [up to 12426120] (imputed)
Lung cancer x radon exposure interaction (1df)
49 European ancestry high radon exposure cases, 15,028 European ancestry low radon exposure cases, 259 European ancestry high radon exposure controls, 13,263 European ancestry low radon exposure controls
Elevated fasting plasma glucose
76 Chinese ancestry cases, 435 Chinese ancestry controls
Mucinous adenocarcinoma in colorectal cancer
57 European ancestry cases, 448 European ancestry controls
5,900 East Asian cases, 20,521 East Asian controls, 14,361 European ancestry cases, 43,923 European ancestry controls
5,236 Japanese ancestry cases, 39,556 Japanese ancestry controls
Uterine fibroids (MTAG)
645 Japanese ancestry cases, 39,556 Japanese ancestry controls
Endometriosis (MTAG)
647 Japanese ancestry cases, 39,556 Japanese ancestry controls
Ovarian cancer (MTAG)
909 Japanese ancestry cases, 39,556 Japanese ancestry controls
Endometrial cancer (MTAG)
Gynecologic disease
7,315 Japanese ancestry cases, 39,556 Japanese ancestry controls
538 Japanese ancestry cases, 39,556 Japanese ancestry controls
Cervical cancer (MTAG)
7,975 Japanese ancestry cases, 39,556 Japanese ancestry controls
Gynecologic disease (multivariate analysis)
up to 7,975 Japanese ancestry cases, 39,556 Japanese ancestry controls
2,812 European ancestry cases, 3,846 European ancestry controls, 821 African American cases, 2,459 African American controls
2,627 cases, 986 controls
2,297 European American cases, 334 African American cases, 606 Latino American cases, 9,176 European American controls, 2,345 African American controls, 2,893 Latino American controls
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease
2,022 European ancestry individuals without statin treatment, 1,268 European ancestry individuals with statin treatment
Prostate cancer aggressiveness (high vs low)
15,561 European ancestry high aggressive cases, 9,739 European ancestry low aggressive cases
Prostate cancer aggressiveness (high vs low/intermediate)
20,658 European ancestry high aggressive cases, 38,093 European ancestry low/intermediate aggressive cases
Prostate cancer (advanced vs non-advanced)
14,160 European ancestry advanced cases, 62,421 European ancestry non-advanced cases
Prostate cancer (advanced)
15,167 European ancestry cases, 58,308 European ancestry controls
Prostate cancer (early onset)
6,988 European ancestry cases, 44,256 European ancestry controls
Prostate cancer (Gleason score)
61,978 European ancestry cases
79,148 European ancestry cases, 61,106 European ancestry controls
Neuromyelitis optica
66 European ancestry AQP4-IgG antibody seropositive cases, 63 European ancestry AQP4-IgG antibody seronegative cases, 784 European ancestry controls
66 European ancestry AQP4-IgG antibody seropositive cases, 20 European ancestry AQP4-IgG antibody seronegative cases, 460 European ancestry controls
Neuromyelitis optica (AQP4-IgG-positive)
66 European ancestry cases, 784 European ancestry controls
66 European ancestry cases, 460 European ancestry controls
Neuromyelitis optica (AQP4-IgG-negative)
63 European ancestry cases, 784 European ancestry controls
20 European ancestry cases, 460 European ancestry controls
Executive function in ADHD
547 East Asian ancestry cases
Disease free survival in colon cancer
4,319 European ancestry cases, 358 African American cases, 190 Asian cases, 107 cases
Survival in colon cancer
418,642 British ancestry individuals
Advanced age-related macular degeneration
12,711 European ancestry cases, 14,590 European ancestry controls
Delta-5 desaturase activity response to n3-polyunsaturated fat supplement
81 extreme responder individuals, 60 non-responder individuals
Delta-6 desaturase activity response to n3-polyunsaturated fat supplement
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels)
619 Croatian ancestry cases, 1,994 Croatian ancestry controls
Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels)
81 responder individuals, 60 non-responder individuals
41,073 European ancestry individuals, 2,610 Erasmus Rucphen (founder/genetic isolate) individuals, 509 Talana (founder/genetic isolate) individuals, 15,044 East Asian ancestry individuals, 2,275 Malay ancestry individuals, 2,110 Indian ancestry individuals, 2,506 Asian ancestry individuals
Affymetrix, Illumina [~ 9300000] (imputed)
Myopia (age of diagnosis)
104,293 European ancestry individuals
Spherical equivalent or myopia (age of diagnosis)
145,366 European ancestry individuals, 2,610 Erasmus Rucphen (founder/genetic isolate) individuals, 509 Talana (founder/genetic isolate) individuals, 15,044 East Asian ancestry individuals, 2,275 Malay ancestry individuals, 2,110 Indian ancestry individuals, 2,506 Asian ancestry individuals
Affymetrix, Illumina [~ 11000000] (imputed)
Dysmenorrheic pain severity
5,734 Japanese ancestry female individuals
5,614 Japanese ancestry female individuals
Menstruation quality of life impact (dysmenorrhea)
3,573 Japanese ancestry female cases, 2,161 Japanese ancestry female controls
3,580 Japanese ancestry female cases, 2,034 Japanese ancestry female controls
Pain medicine use during menstruation
1,813 Japanese ancestry female cases, 3,921 Japanese ancestry female controls
1,494 Japanese ancestry female cases, 4,120 Japanese ancestry female controls
Menstruation quality of life impact (fever)
112 Japanese ancestry female cases, 5,622 Japanese ancestry female controls
157 Japanese ancestry female cases, 5,457 Japanese ancestry female controls
Heavy vaginal discharge
457 Japanese ancestry female cases, 5,277 Japanese ancestry female controls
471 Japanese ancestry female cases, 5,143 Japanese ancestry female controls
Menstruation quality of life impact (acne)
1,115 Japanese ancestry female cases, 4,619 Japanese ancestry female controls
1,204 Japanese ancestry female cases, 4,410 Japanese ancestry female controls
Menstruation quality of life impact (aggressiveness)
899 Japanese ancestry female cases, 4,835 Japanese ancestry female controls
1,030 Japanese ancestry female cases, 4,584 Japanese ancestry female controls
Menstruation quality of life impact (increased appetite)
760 Japanese ancestry female cases, 4,974 Japanese ancestry female controls
903 Japanese ancestry female cases, 4,711 Japanese ancestry female controls
Menstruation quality of life impact (bowel movement)
903 Japanese ancestry female cases, 4,831 Japanese ancestry female controls
921 Japanese ancestry female cases, 4,693 Japanese ancestry female controls
Menstruation quality of life impact (depression)
1,863 Japanese ancestry female cases, 3,871 Japanese ancestry female controls
2,005 Japanese ancestry female cases, 3,609 Japanese ancestry female controls
Menstruation quality of life impact (edema)
1,109 Japanese ancestry female cases, 4,625 Japanese ancestry female controls
1,331 Japanese ancestry female cases, 4,283 Japanese ancestry female controls
Menstruation quality of life impact (headache)
1,758 Japanese ancestry female cases, 3,976 Japanese ancestry female controls
1,763 Japanese ancestry female cases, 3,851 Japanese ancestry female controls
Menstruation quality of life impact (joint pain)
251 Japanese ancestry female cases, 5,483 Japanese ancestry female controls
277 Japanese ancestry female cases, 5,337 Japanese ancestry female controls
Menstruation quality of life impact (loss of concentration)
995 Japanese ancestry female cases, 4,739 Japanese ancestry female controls
1,081 Japanese ancestry female cases, 4,533 Japanese ancestry female controls
Menstruation quality of life impact (nervousness)
1,904 Japanese ancestry female cases, 3,830 Japanese ancestry female controls
2,017 Japanese ancestry female cases, 3,597 Japanese ancestry female controls
Menstruation quality of life impact (pressure in breast)
642 Japanese ancestry female cases, 5,092 Japanese ancestry female controls
667 Japanese ancestry female cases, 4,947 Japanese ancestry female controls
Menstruation quality of life impact (sleepiness)
1,902 Japanese ancestry female cases, 3,832 Japanese ancestry female controls
1,934 Japanese ancestry female cases, 3,680 Japanese ancestry female controls
Menstruation quality of life impact (stiff neck)
937 Japanese ancestry female cases, 4,797 Japanese ancestry female controls
944 Japanese ancestry female cases, 4,670 Japanese ancestry female controls
Vaginal discharge (itching)
676 Japanese ancestry female cases, 5,058 Japanese ancestry female controls
669 Japanese ancestry female cases, 4,945 Japanese ancestry female controls
Vaginal discharge (metrorrhagia)
406 Japanese ancestry female cases, 5,328 Japanese ancestry female controls
302 Japanese ancestry female cases, 5,312 Japanese ancestry female controls
Vaginal discharge (smell)
367 Japanese ancestry female cases, 5,367 Japanese ancestry female controls
392 Japanese ancestry female cases, 5,222 Japanese ancestry female controls
Breast size
5,609 Japanese ancestry female individuals
Bone mineral density (total hip)
232 European ancestry high BMD individuals, 1,026 European ancestry moderate high BMD individuals, 852 European ancestry low BMD individuals
High bone mineral density
232 European ancestry cases, 5,667 population controls
Lumbar spine bone mineral density
232 European ancestry high BMD individuals, 613 European ancestry moderate high BMD individuals, 535 European ancestry low BMD individuals
30,970 individuals
Cannabis use (age at onset)
24,953 European ancestry individuals
3,735 European ancestry individuals
Affymetrix, Illumina, Perlegen [6163759] (imputed)
Dietary macronutrient intake
91,114 European ancestry individuals
177,315 European ancestry individuals
Affymetrix, Illumina [1180000] (imputed)
Electroencephalogram traits
up to 8,425 European and unknown ancestry individuals
Affymetrix, Illumina, Perlegen [at least 4959085] (imputed)
Bipolar disorder or major depressive disorder
164,933 European ancestry major depressive disorder cases, 20,352 European ancestry bipolar disorder cases, 439,741 European ancestry controls
Urate levels
110,238 European ancestry individuals, 21,471 East Asian individuals
Memory decline
709 European ancestry individuals
Severe aplastic anemia
359 European ancestry cases, 1,396 European ancestry controls
175 European ancestry cases, 1,059 European ancestry controls
Clinical remission in asthma
178 European ancestry remitted asthma cases, 612 European ancestry persistent asthma controls
135 European ancestry remitted asthma cases, 321 European ancestry persistent asthma controls
Complete remission in asthma
55 European ancestry remitted asthma cases, 612 European ancestry persistent asthma controls
21 European ancestry remitted asthma cases, 321 European ancestry persistent asthma controls
1,152 Japanese ancestry cases, 5,774 Japanese ancestry controls
1,051 Japanese ancestry cases, 1,505 Japanese ancestry controls
3,444 Japanese ancestry cases, 4,636 Japanese ancestry controls
139,555 European ancestry individuals
Maximum cranial length
4,419 European ancestry individuals
Cephalic index
Maximum cranial width
1,621 Chinese ancestry individuals
2,788 Chinese ancestry individuals
Short-term memory (visuospatial task)
1,623 Chinese ancestry individuals
2,790 Chinese ancestry individuals
Short-term memory (shared component of digit-span and visuospatial tasks)
up to 1,623 Chinese ancestry individuals
up to 2,790 Chinese ancestry individuals
Long-term memory (delayed word recall task)
1,522 Chinese ancestry individuals
1,862 Chinese ancestry individuals
up to 243 European ancestry cases, up to 23 East Asian ancestry cases, up to 4,816 European ancestry controls, up to 447 East Asian ancestry controls
up to 149 European ancestry cases, up to 14 East Asian ancestry cases, up to 2,935 European ancestry controls, up to 272 East Asian ancestry controls
up to 221 European ancestry female cases, up to 20 East Asian ancestry female cases, up to 4,258 European ancestry female controls, up to 395 East Asian ancestry female controls
up to 134 European ancestry female cases, up to 12 East Asian ancestry female cases, up to 2,608 European ancestry female controls, up to 242 East Asian female controls
Hirschsprung disease
105 European ancestry cases, 386 European ancestry controls
154 Swedish ancestry cases, 177 European ancestry controls
68 European ancestry cases, 386 European ancestry controls
Circulating odd-numbered chain saturated fatty acid levels (C15:0)
11,494 European ancestry individuals
Circulating odd-numbered chain saturated fatty acid levels (C17:0)
6,016 European ancestry individuals
Circulating odd-numbered chain saturated fatty acid levels (C15:0+C17:0)
Circulating odd-numbered chain saturated fatty acid levels (C19:0)
1,910 European ancestry individuals
Circulating odd-numbered chain saturated fatty acid levels (C23:0)
7,582 European ancestry individuals
4,831 European ancestry male cases, 3,206 European ancestry female cases, 5,216 European ancestry male controls, 5,470 European ancestry female controls
Glioblastoma
2,835 European ancestry male cases, 1,682 European ancestry female cases, 5,216 European ancestry male controls, 5,470 European ancestry female controls
Non-glioblastoma glioma
1,716 European ancestry male cases, 1,320 European ancestry female cases, 5,216 European ancestry male controls, 5,470 European ancestry female controls
8,239 European ancestry individuals
8,429 European ancestry individuals
Stroke and BMI (pleiotropy)
40,585 European ancestry stroke cases, 406,111 European ancestry controls, 681,275 European ancestry individuals
NASH resolution in nonalcoholic steatohepatitis
25 European ancestry cases, 116 European ancestry controls
Pruritus in nonalcoholic steatohepatitis
approximately 31 European ancestry cases, approximately 166 European ancestry controls
Fibrosis improvement in nonalcoholic steatohepatitis
38 European ancestry cases, 103 European ancestry controls
1,353 Arab ancestry individuals
1,176 Arab ancestry individuals
Serum total polyunsaturated fatty acid concentration in metabolic syndrome
426 Mediterranean individuals
Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome
Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome
Serum docosahexaenoic fatty acid concentration in metabolic syndrome
Serum linoleic acid concentration in metabolic syndrome
Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome
Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome
239 Mediterranean women, 187 Mediterranean men
Serum polyunsaturated fatty acid concentration x Mediterranean diet adherence interaction in metabolic syndrome
248 Mediterranean individuals with low adherence to Mediterranean diet, 178 Mediterranean individuals with high adherence to Mediterranean diet
Cutaneous squamous cell carcinoma
19,149 European ancestry cases, 680,049 European ancestry controls
Midgestational total 25-hydroxyvitamin D levels (maternal genetic effect)
269 European ancestry individuals, 323 Hispanic individuals, 115 East Asian ancestry individuals, 23 African American individuals, 23 South Asian ancestry individuals, 23 individuals
Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect)
Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect)
Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect)
Cryptosporidiosis
183 Bangladeshi ancestry cases, 873 Bangladeshi ancestry controls
58,610 Japanese ancestry individuals
152,634 Japanese ancestry individuals
Green tea consumption
152,653 Japanese ancestry individuals
Milk consumption
152,965 Japanese ancestry individuals
Yoghurt consumption
83,150 Japanese ancestry men, 69,757 Japanese ancestry women
Cheese consumption
152,714 Japanese ancestry individuals
Natto consumption
152,678 Japanese ancestry individuals
Tofu consumption
152,943 Japanese ancestry individuals
153,048 Japanese ancestry individuals
Small whole fish consumption
82,791 Japanese ancestry men, 69,486 Japanese ancestry women
Vegetable consumption
153,001 Japanese ancestry individuals
Meat consumption
152,857 Japanese ancestry individuals
Alcohol consumption (drinkers vs non-drinkers)
83,713 Japanese ancestry ever drinkers, 81,371 Japanese ancestry never drinkers
Axial length
1,055 individuals
Spherical error
Axial length or spherical error (univariate decomposition analysis)
Hepatocellular carcinoma in hepatitis B infection
473 Japanese ancestry chronic hepatitis and hepatocellular carcinoma cases, 516 Japanese ancestry asymptomatic carriers or chronic hepatitis cases without hepatocellular carcinoma
153 Japanese ancestry chronic hepatitis and hepatocellular carcinoma cases, 614 Japanese ancestry asymptomatic carriers or chronic hepatitis cases without hepatocellular carcinoma, 94 Chinese ancestry chronic hepatitis and hepatocellular carcinoma cases, 187 Chinese ancestry asymptomatic carriers or chronic hepatitis cases without hepatocellular carcinoma, 185 Thai ancestry chronic hepatitis and hepatocellular carcinoma cases, 198 Thai ancestry asymptomatic carriers or chronic hepatitis cases without hepatocellular carcinoma
253,288 European ancestry individuals
336,474 European ancestry individuals
Refractory celiac disease type II
38 Dutch ancestry cases, 846 Dutch ancestry controls
56 European ancestry cases, 1,285 European ancestry controls
Age at loss of ambulation in Duchenne muscular dystrophy
243 European ancestry cases, 10 cases
Response to ketogenic dietary therapies in epilepsy
123 responders, 112 non-responders
20,704 Hispanic or Latin American individuals
Hemoglobin concentration
16,186 African American individuals, 20,692 Hispanic or Latin American individuals, 29,379 European ancestry individuals, 630 Asian ancestry individuals, 601 Native American ancestry individuals, 381 individuals
16,186 African American individuals
29,379 European ancestry individuals
20,692 Hispanic or Latin American individuals
17,272 Hispanic or Latin American individuals
Huntington's disease (age at onset)
374 Venezuelan ancestry individuals, 4,061 European ancestry individuals
23,572 East Asian ancestry cases, 48,700 East Asian ancestry controls
58,131 European ancestry cases, 67,347 European ancestry controls
Affymetrix, Illumina [up to 47000000] (imputed)
Maternal nondisjunction of chromosome 21 (mothers vs fathers)
705 mothers, 645 fathers
Maternal nondisjunction of chromosome 21 (MI error vs fathers)
535 mothers, 645 fathers
Maternal nondisjunction of chromosome 21 (MII error vs fathers)
157 mothers, 645 fathers
Maternal nondisjunction of chromosome 21 (MI error vs MII error)
535 mothers (meiosis I error), 157 mothers (meiosis II error)
IgA nephropathy
188 Korean ancestry cases, 455 Korean ancestry controls
310 Korean ancestry cases, 438 Korean ancestry controls
Body fat distribution (arm fat ratio)
55,006 British ancestry males, 61,132 British ancestry females
112,425 British ancestry males, 133,936 British ancestry females
Body fat distribution (leg fat ratio)
Body fat distribution (trunk fat ratio)
Acute respiratory distress syndrome in sepsis
274 European ancestry cases, 316 European ancestry controls
359 European ancestry cases, 986 European ancestry controls
Response to statins (LDL cholesterol percent change)
28,616 European ancestry individuals, 1,205 African ancestry individuals, 2,350 East Asian ancestry individuals, 2,703 Hispanic/Latino individuals
Low density lipoprotein cholesterol levels (on statin treatment)
Response to statins (LDL cholesterol change)
Diabetic macular edema in type 2 diabetes
270 European ancestry cases, 435 European ancestry controls
Proliferative diabetic retinopathy in type 2 diabetes
176 European ancestry cases, 435 European ancestry controls
Glycemic traits (multi-trait analysis)
5,947 European ancestry individuals
Childhood steroid-sensitive nephrotic syndrome
224 Japanese ancestry cases, 412 Japanese ancestry controls
216 Japanese ancestry cases, 719 Japanese ancestry controls
Serum metabolite levels (CMS)
6,263 Finnish ancestry men
Change in serum metabolite levels
3,351 Finnish ancestry men
Change in serum metabolite levels (CMS)
Serum metabolite levels
Cerebrospinal fluid beta-site APP cleaving enzyme levels
86 European ancestry Alzheimer's disease cases, 163 European ancestry mild cognitive impairment cases, 91 European ancestry controls
Plasma neurofilament light levels
176 European ancestry mild cognitive impairment cases, 172 European ancestry Alzheimer's disease cases, 179 European ancestry controls
Asthma x air pollution interaction (2df)
606 Hispanic cases, 792 Hispanic controls, 643 European ancestry cases, 959 European ancestry controls
Asthma x Hispanic interaction (2df)
Bone mineral content
1,030 Hispanic or Latin American children
Bone mineral density
T-cell acute lymphoblastic leukaemia
157 African American child cases, 699 European ancestry child cases, 126 Hispanic child cases, 209 child cases, 12,178 European, African American and unknown ancestry controls
26 African American child cases, 75 European ancestry child cases, 9 Hispanic child cases, 7 child cases, 5,518 European, African American and unknown ancestry controls
Affymetrix, Illumina [7967910] (imputed)
Inflammatory biomarkers
up to 957 Swedish ancestry individuals
C-peptide levels
877 Indo-European ancestry individuals
1,829 Indo-European ancestry individuals, 773 Hispanic individuals
291,107 British ancestry individuals
1,813 African American and African ancestry cases, 8,871 African American and African ancestry controls
Renal complication in type 2 diabetes
882 East Asian ancestry cases, 2,231 East Asian ancestry controls
2,967 cases, 3075 controls
Longitudinal brain connectivity change (Louvain modularity)
57 European ancestry individuals
Longitudinal brain connectivity change (transitivity)
Longitudinal brain connectivity change (global efficiency)
Longitudinal brain connectivity change (characteristic path length)
443,734 European ancestry individuals
939 Japanese ancestry cases, 10,344 Japanese ancestry controls
38,143 Japanese ancestry cases, 110,686 Japanese ancestry controls
11,283 Japanese ancestry individuals
148,829 Japanese ancestry individuals
Serum creatinine levels
30,822 British ancestry normal blood pressure individuals, 25,242 British ancestry elevated blood pressure individuals, 50,461 British ancestry stage 1 hypertension individuals, 75,286 British ancestry stage 2 hypertension individuals, 3,754 British ancestry hypertension crisis individuals
Airflow obstruction in ever smokers
2,534 European ancestry unaffected individuals, 607 European ancestry stage 1 individuals, 1,424 European ancestry stage 2 individuals, 909 European ancestry stage 3 individuals, 487 European ancestry stage 4 individuals
Sitting height
6,034 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
6,007 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
6,006 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
6,017 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Iron levels
6,010 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
5,972 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Sodium levels
6,018 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Serum total protein level
Ferritin levels
5,947 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
5,925 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Pro B-type natriuretic peptide
5,516 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Unsaturated iron binding capacity
5,956 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Activated partial thromboplastin time
5,988 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Prothrombin time
5,989 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
International normalisation ratio
5,987 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Fibrinogen
5,984 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
5,935 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
6,044 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
6,039 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Calcium levels
6,020 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
6,013 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Magnesium levels
5,996 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Potassium levels
Triglycerides
Bicarbonate levels
6,012 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
5,344 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
4,650 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Total bilirubin levels
5,944 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
5,727 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
5,865 Greater Middle Eastern (Middle Eastern, North African or Persian) individuals
Drug-induced liver injury in interferon-beta-treated multiple sclerosis
38 European ancestry cases, 113 European ancestry controls
18 European ancestry cases, 13 European ancestry controls
Dermatomyositis or juvenile dermatomyositis
879 European dermatomyositis cases, 15,651 European juvenile dermatomyositis ancestry controls
Polymyositis
931 European ancestry cases, 15,651 European ancestry controls
Idiopathic inflammatory myopathy
2,556 European ancestry cases, 15,651 European ancestry controls
Allergic rhinitis
59,762 European and unknown ancestry cases, 152,358 European and unknown ancestry controls
60,720 European ancestry cases, 618,527 European ancestry controls
Affymetrix, Illumina, Perlegen [16531985] (imputed)
Allergic sensitization
8,040 European ancestry cases, 16,441 European ancestry controls
Affymetrix, Illumina [16531985] (imputed)
Non-allergic rhinitis
2,028 European and unknown ancestry cases, 9,606 European and unknown ancestry controls
Affymetrix, Illumina [12291687] (imputed)
Infective endocarditis in Staphylococcus aureus infection
67 European ancestry cases, 72 European ancestry controls
57 Danish ancestry cases, 123 Danish ancestry controls
18,381 European ancestry cases, 27,969 European ancestry controls
2,119 European ancestry cases, 142,379 European ancestry controls
Autism and major depressive disorder (MTAG)
18,381 European ancestry autism cases, 27,969 European ancestry controls, 111,902 major depression cases, 312,113 controls
Autism and schizophrenia (MTAG)
18,381 European ancestry autism cases, 27,969 European ancestry controls, 34,129 schizophrenia cases, 45,512 controls
Autism and educational attainment (MTAG)
18,381 European ancestry autism cases, 27,969 European ancestry controls, 328,917 individuals with educational attainment data
Serum urea levels
13,312 European ancestry individuals
7,379 European ancestry individuals
Alzheimer's disease (late onset)
21,982 European ancestry cases, 41,944 European ancestry controls
up to 13,292 European ancestry cases, up to 17,219 European ancestry controls
Affymetrix, Illumina [11480632] (imputed)
Estimated glomerular filtration rate in coronary artery disease and impaired kidney function
499 European ancestry cases
574 European ancestry cases
1,121 Croatian ancestry individuals
623 Croatian ancestry individuals
Triiodothyronine/thyroxine ratio
Insomnia symptoms (never/rarely vs. sometimes/usually)
345,022 European ancestry cases, 108,357 European ancestry controls
17,140 European ancestry cases, 61,850 European ancestry controls
Insomnia symptoms (never/rarely vs. usually)
129,270 European ancestry cases, 108,357 European ancestry controls
Anthracycline-induced cardiotoxicity
53 European ancestry breast cancer cases, 18 European ancestry controls
52 European ancestry breast cancer cases, 31 European ancestry controls
250 Korean ancestry cases, 296 Korean ancestry controls
Tourette syndrome
4,271 European ancestry cases, 548 European ancestry cases from 207 families, 9,488 European ancestry controls
706 Icelandic ancestry cases, 6,068 Icelandic ancestry controls
Arsenic metabolism
2,428 American Indian ancestry individuals
Crohn's disease or systemic sclerosis
2,281 European ancestry systemic sclerosis cases, 1,988 European ancestry Crohn’s disease cases, 7,388 European ancestry controls
3,453 European ancestry systemic sclerosis cases, 2,600 European ancestry Crohn’s disease cases, 7,180 European ancestry controls
Thyroid volume in Hashimoto’s thyroiditis
345 European ancestry individuals
Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia
up to 454 European ancestry individuals
DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia
443 European ancestry individuals
DNA-incorporated thioguanine to erythrocyte thioguanine ratio in 6-mercaptopurine-treated acute lymphoblastic leukaemia
up to 443 European ancestry individuals
up to 136 European ancestry individuals
Erythrocyte thioguanine concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia
452 European ancestry individuals
Follicle stimulating hormone levels
2,590 Han Chinese ancestry individuals
Follicle stimulating hormone in healthy women
708 Han Chinese ancestry individuals
Follicle stimulating hormone levels in polycystic ovary syndrome
1,882 Han Chinese ancestry individuals
Luteinizing hormone levels in polycystic ovary syndrome
Luteinizing hormone levels in healthy women
720 Han Chinese ancestry individuals
Luteinizing hormone levels
Pelvic organ prolapse
15,010 European ancestry cases, 340,734 European ancestry controls
Affymetrix, Illumina [37144863] (imputed)
Modic changes
994 European ancestry cases, 835 European ancestry controls
688,809 European ancestry individuals
Depressed affect
357,957 European ancestry individuals
Worry
348,219 European ancestry individuals
449,484 European ancestry individuals
Ocular sarcoidosis
260 African American cases, 1,551 African American controls
Ocular sarcoidosis in sarcoidosis
260 African American cases, 513 African American controls
35 European ancestry cases, 2,046 European ancestry controls
35 European ancestry cases, 221 European ancestry controls
Meconium ileus in cystic fibrosis
1,115 European ancestry cases, 5,655 European ancestry controls
35,735 cases, 222,076 controls
Affymetrix, Illumina [6224355] (imputed)
IgG N-glycosylation phenotypes (multivariate analysis)
8,090 European ancestry individuals
2,388 European ancestry individuals
440,546 European ancestry individuals
441,016 European ancestry individuals
Apolipoprotein B levels
439,214 European ancestry individuals
403,943 European ancestry individuals
Apolipoprotein A1 levels
393,193 European ancestry individuals
Type 1 diabetes
9,266 European ancestry cases, 15,574 European ancestry controls
4,329 European ancestry cases, 9,543 European ancestry controls
Affymetrix, Illumina [9061522] (imputed)
1,627 Han Chinese ancestry individuals with osteoporosis-related bone measurements, 1,475 Han Chinese ancestry schizophrenia cases, 1,022 Han Chinese ancestry schizophrenia controls
Osteoporosis-related phenotypes (MTAG)
Urinary calcium excretion
6,462 European ancestry individuals
Urinary magnesium excretion
Urinary uric acid excretion
Urinary volume
Reading disability
4,494 European ancestry cases, 306 European ancestry siblings
Leukocyte telomere length
78,592 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 30071938] (imputed)
1,482 Japanese ancestry cases, 5,774 Japanese ancestry controls
Type 1 diabetes in high risk HLA genotype individuals (time to event)
5,806 European ancestry children
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event)
Freckles
7,148 Japanese ancestry female cases, 4,034 Japanese ancestry female controls
Double-edged eyelids
2,069 Japanese ancestry female cases, 3,545 Japanese ancestry female controls
Thick vs thin eyebrows
1,153 Japanese ancestry female thick eyebrow individuals, 2,788 Japanese ancestry female thin eyebrow individuals
Straight vs curly hair
2,532 Japanese ancestry female straight hair individuals, 2,346 Japanese ancestry female curly hair individuals
Excessive hairiness
3,830 Japanese ancestry female cases, 7,414 Japanese ancestry female controls
Excessive sweating
1,245 Japanese ancestry female cases, 3,293 Japanese ancestry female controls
Age spots
3,815 Japanese ancestry female cases, 7,438 Japanese ancestry female controls
Schizophrenia or schizoaffective disorder
6,152 African ancestry cases, 1,234 Latino cases, 34,241 European and East Asian ancestry cases, 3,918 African ancestry controls, 3,090 Latino controls, 45,604 European and East Asian ancestry controls, 1,235 European ancestry trios
Childhood onset systemic lupus erythematosus
96 Korean ancestry childhood onset cases, 685 Korean ancestry adult onset cases
1,999 Han Chinese ancestry individuals
113,882 European ancestry cases, 322,354 European ancestry controls
772,825 individuals
207,229 European ancestry ever smoker cases, 243,177 European ancestry never smoker controls
Cleft lip with or without cleft palate x maternal periconceptional alcohol use interaction (parent of origin effect)
825 European ancestry case-parent duos or trios, 1,024 Asian ancestry case-parent duos or trios, 59 case-parent duos or trios
Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect)
Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect)
Osteoarthritis of the hand
8,743 individuals
2,836 European ancestry individuals, 1,175 individuals
Insulin-related traits (multivariate analysis)
62,205 individuals
Opioid dependence in opioid exposure
1,231 African ancestry cases, 3,272 European ancestry cases, 1,297 African ancestry controls, 2,876 European ancestry controls
Opioid dependence
1,027 African ancestry cases, 3,211 European ancestry cases, 6,111 African ancestry controls, 11,589 European ancestry controls
Opioid exposure
1,297 African ancestry cases, 2,876 European ancestry cases, 7,063 African ancestry controls, 25,437 European ancestry controls
Clozapine-induced myocarditis in schizophrenia
33 cases, 62 controls
3,567 European ancestry men, 4,171 European ancestry women
Affymetrix, Illumina [6523511] (imputed)
Frequency of relapse in mepolizumab-treated eosinophilic granulomatosis with polyangiitis
61 individuals
Average oral glucocorticoid dose in mepolizumab-treated eosinophilic granulomatosis with polyangiitis
Accrued duration of remission in mepolizumab-treated eosinophilic granulomatosis with polyangiitis
Response to anti-VEGF treatment in neovascular age-related macular degeneration (visual acuity)
187 Israeli ancestry individuals
108 Israeli ancestry individuals
292 Iranian ancestry cases, 294 Iranian ancestry controls
684 Iranian ancestry cases, 532 Iranian ancestry controls, 1,215 Turkish ancestry cases, 1,278 Turkish ancestry controls
1,518 Finnish ancestry individuals
Alzheimer's disease (onset at age over 80)
2,399 European ancestry cases, 4,160 European ancestry controls
Affymetrix, Illumina [38043082] (imputed)
Alzheimer's disease (onset between ages 58 and 79)
7,316 European ancestry cases, 7,579 European ancestry controls
Serum alpha-fetoprotein levels
22,686 Icelandic ancestry individuals
Serum carcinoembryonic antigen levels
22,309 Icelandic ancestry individuals
Serum cancer antigen 15.3 levels
7,107 Icelandic ancestry individuals
Serum cancer antigen 19.9 levels
9,945 Icelandic ancestry individuals
Serum cancer antigen 125 levels
9,824 Icelandic ancestry individuals
162,774 Icelandic ancestry individuals
2,118 Erasmus Rucphen (founder/genetic isolate) individuals
5,578 European ancestry individuals
5,586 European ancestry individuals
4,221 European ancestry individuals
2,096 European ancestry individuals
5,614 European ancestry individuals
6,883 European ancestry individuals
6,891 European ancestry individuals
5,533 European ancestry individuals
6,228 European ancestry individuals
2,080 European ancestry individuals
2,083 European ancestry individuals
7,113 European ancestry individuals
7,116 European ancestry individuals
Aortic valve stenosis
3,469 European ancestry cases, 41,234 European ancestry controls
3,751 European ancestry cases, 236,142 European ancestry controls, 2,175 cases, 25,347 controls
Conjunctival UV autofluorescence (CUVAF)
1,251 European ancestry individuals
Lean mass index
2,207 European ancestry individuals
44,296 European ancestry individuals
Breast cancer (estrogen-receptor positive)
1,325 cases, 1,310 controls
Breast cancer (estrogen-receptor negative)
212 cases, 1,310 controls
Breast cancer (progesterone-receptor positive)
1,049 cases, 1,310 controls
Breast cancer (progesterone-receptor negative)
419 cases, 1,310 controls
Breast cancer (HER2 positive)
194 cases, 1,310 controls
Breast cancer (HER2 negative)
932 cases, 1,310 controls
1,704 cases, 1,310 controls
Spontaneous adipocyte lipolysis
856 European ancestry individuals
Stimulated adipocyte lipolysis
874 European ancestry individuals
Tacrolimus trough concentration in kidney transplant patients
1,363 European ancestry individuals, 299 African American individuals
609 European ancestry individuals, 171 African American individuals
Nephrotoxicity in tacrolimus-treated kidney transplant patients (time to event)
1,352 European ancestry individuals
609 European ancestry individuals
Nephrotoxicity in cyclosporine-treated kidney transplant patients (time to event)
475 European ancestry individuals
63 European ancestry individuals
Anemia in mycophenolic acid treated kidney transplant patients (time to event)
1,785 European ancestry individuals
438 European ancestry individuals
Leukopenia in mycophenolic acid treated kidney transplant patients (time to event)
1,785 European ancestry individuals, 338 African American individuals
657 European ancestry individuals, 171 African American individuals
New onset diabetes in calcineurin inhibitor treated kidney transplant patients (time to event)
1,235 European ancestry individuals, 256 African American individuals
487 European ancestry individuals, 94 African American individuals
Alzheimer's disease or fasting glucose levels (pleiotropy)
54,162 European ancestry cases, 58,047 European ancestry individuals
Alzheimer's disease or fasting insulin levels (pleiotropy)
54,162 European ancestry cases, 51,750 European ancestry individuals
Alzheimer's disease or HDL levels (pleiotropy)
54,162 European ancestry cases, 60,812 European ancestry individuals
Crohn's disease (time to progression)
662 European ancestry individuals
Crohn's disease (time to first abdominal surgery)
1,360 European ancestry individuals
Crohn's disease (indolent vs progressive)
562 European ancestry individuals with indolent disease, 701 European ancestry individuals with progressive disease
1,340 European ancestry individuals
Nicotine dependence symptom count
3,529 African American individuals, 4,117 European American individuals
Attention deficit hyperactivity disorder or hippocampal volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 24,704 European ancestry individuals
Attention deficit hyperactivity disorder or nucleus accumbens volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 11,709 European ancestry individuals
Attention deficit hyperactivity disorder or caudate nucleus volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 11,772 European ancestry individuals
Hippocampal volume
24,704 European ancestry individuals
Intracranial volume
24,024 European ancestry individuals
Attention deficit hyperactivity disorder or intracranial volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 24,024 European ancestry individuals
Attention deficit hyperactivity disorder or putamen volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 11,646 European ancestry individuals
Attention deficit hyperactivity disorder or amygdala volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 11,757 European ancestry individuals
Attention deficit hyperactivity disorder or pallidum volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 11,640 European ancestry individuals
Attention deficit hyperactivity disorder or thalamus volume (pleiotropy)
19,099 European ancestry ADHD cases, 1,084 ADHD cases, 34,194 European ancestry controls, 997 controls, 11,694 European ancestry individuals
Thiopurine-induced myelosuppression in inflammatory bowel disease
311 European ancestry cases, 608 European ancestry controls
31,230 Japanese ancestry individuals
5,140 Japanese ancestry individuals
Household income (MTAG)
505,541 British and unknown ancestry individuals
286,301 British ancestry individuals
995 Han Chinese ancestry cases, 1,008 Han Chinese ancestry controls
2,404 Han Chinese ancestry cases, 3,639 Han Chinese ancestry controls
18,915 European ancestry cases, 239,773 European ancestry controls
Eczema
7,884 European ancestry cases, 239,773 European ancestry controls
21,000 cases, 96,000 controls
Hay fever and/or eczema
84,034 European ancestry cases, 239,773 European ancestry controls
Allergic disease (asthma, hay fever or eczema)
106,772 European ancestry cases, 239,773 European ancestry controls
83,335 cases, 34,934 controls
41,926 European ancestry cases, 239,773 European ancestry controls
10,365 cases, 16,100 controls
33,992 European ancestry individuals
14,727 European ancestry individuals, 2,943 individuals
Cortical surface area
Left ventricular mass x antihypertensive treatment interaction
up to 2,068 African American individuals
up to 613 European ancestry individuals
Affymetrix, Illumina [up to 2191657] (imputed)
Relative wall thickness x antihypertensive treatment interaction
Affymetrix, Illumina [up to 2191661] (imputed)
Creativity
4,664 Han Chinese ancestry individuals
Adverse response to inhaled corticosteroid treatment x age interaction in asthma
407 European ancestry cases, 376 European ancestry controls
287 European ancestry cases, 251 European ancestry controls
Affymetrix, Illumina [8589102] (imputed)
Calcific aortic valve stenosis
5,115 European ancestry cases, 354,072 European ancestry controls
Affymetrix, Illumina [8000000] (imputed)
Multiple sclerosis
14,802 European and unknown ancestry cases, 26,703 European and unknown ancestry controls
32,627 European and unknown ancestry cases, 41,672 European and unknown ancestry controls
Affymetrix, Illumina [8278136] (imputed)
Carotid intima media thickness x smoking interaction
465 West African ancestry male smokers, 1,311 West African ancestry male non-smokers
Acute cholecystitis
900 European ancestry cases, 23,727 European ancestry controls
Cholelithiasis
up to 2,377 European ancestry cases, 22,203 European ancestry controls
Endometrial cancer (endometrioid histology)
8,758 European ancestry cases, 46,126 European ancestry controls
Affymetrix, Illumina [~ 11700000] (imputed)
Endometrial cancer (Non-endometrioid histology)
1,230 European ancestry cases, 35,447 European ancestry controls
12,906 European ancestry cases, 108,979 European ancestry controls
Response to ranibizumab in age-related macular degeneration (exudative)
361 Japanese ancestry responder cases, 73 Japanese ancestry non-responder controls
363 Japanese ancestry responder cases, 122 Japanese ancestry non-responder controls
Offspring birth weight
210,267 European ancestry individuals, 19,802 individuals
Affymetrix, Illumina [14869762] (imputed)
298,142 European ancestry individuals, 6,635 African American individuals, 1,449 Filipino individuals, 420 Turkish individuals, 365 Moroccan individuals, 395 Surinamese individuals, 1,052 Afro-Caribbean individuals, 612 Hispanic individuals, 1,180 Thai individuals, 840 Chinese ancestry individuals, 10,133 individuals
Affymetrix, Illumina [15144367] (imputed)
Relative amplitude of rest-activity cycles
77,440 European ancestry individuals
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles)
at least 2,700 European ancestry cases, at least 68,300 European ancestry controls
Nicotine dependence and major depression (severity of comorbidity)
3,724 African American individuals
Ewing sarcoma
733 European ancestry cases, 1,346 European ancestry controls
657 European ancestry cases, 4,078 European ancestry controls
Neutrophil level response to clozapine in treatment-resistant schizophrenia
552 Sub-Saharan African ancestry individuals
Radioiodine-refractory disease in thyroid cancer
244 European ancestry cases, 901 European ancestry controls, 9 African American cases, 46 African American controls
2,370 Erasmus Rucphen Family (founder/genetic isolate) individuals, 29,325 European ancestry individuals
391 Carlantino (founder/genetic isolate) individuals, 981 Friuli Venezia Giulia (founder/genetic isolate) individuals, 31,033 European ancestry individuals, 2,070 African American individuals
Affymetrix, Illumina [at least 19000000] (imputed)
2,177 Erasmus Rucphen Family (founder/genetic isolate) individuals, 23,332 European ancestry individuals
391 Carlantino (founder/genetic isolate) individuals, 981 Friuli Venezia Giulia (founder/genetic isolate) individuals, 30,760 European ancestry individuals, 2,048 African American individuals
2,332 Erasmus Rucphen Family (founder/genetic isolate) individuals, 24,462 European ancestry individuals
391 Carlantino (founder/genetic isolate) individuals, 981 Friuli Venezia Giulia (founder/genetic isolate) individuals, 31,225 European ancestry individuals, 2,048 African American individuals
RR interval (heart rate)
2,006 Erasmus Rucphen Family (founder/genetic isolate) individuals, 26,692 European ancestry individuals
Calcaneus stiffness index
7,742 Taiwanese ancestry individuals
2,955 Korean ancestry individuals
Cortical brain region measurements (area, volume and thickness)
901 children and adolescents
812 children and adolescents
952 European ancestry male cases, 1,789 European ancestry female cases, 6,337 European ancestry male controls, 8,402 European ancestry female controls
Affymetrix, Illumina [2928658] (imputed)
Osteolysis in total hip arthroplasty
1,096 European ancestry cases, 2,418 European ancestry controls
Osteolysis in total hip arthroplasty (time to prosthesis revision)
1,096 European ancestry cases
17,996 cases
10,572 cases
Handedness (Left-handed vs. non-left-handed)
31,856 British ancestry cases, 299,181 British ancestry controls
Handedness (Right-handed vs. non-right-handed)
293,857 British ancestry cases, 37,180 British ancestry controls
Ambidextrousness
5,324 British ancestry cases, 325,713 British ancestry controls
Postoperative survival time in hepatocellular carcinoma
367 East Asian ancestry individuals
758 East Asian ancestry individuals
Facial attractiveness (female raters)
3,928 European ancestry individuals
455 European ancestry individuals
Facial attractiveness (male raters)
1,792 European ancestry male individuals
2,062 European ancestry female individuals
213 European ancestry female individuals
3,921 European ancestry individuals
Targeted genotyping array [X chromosome]
Ankylosing spondylitis
921 Turkish ancestry cases, 907 Turkish ancestry controls, 422 Iranian ancestry cases, 754 Iranian ancestry controls
Executive function (trail making test B)
Perceptual and visual search speed and executive function (trail making test BA)
perceptual and visual search speed (trail making test A) (age interaction)
Executive function (trail making test B) (age interaction)
Perceptual and visual search speed and executive function (trail making test BA) (age interaction)
perceptual and visual search speed (trail making test A)
Resting heart rate
458,969 European ancestry individuals
144,793 European ancestry cases, 313,761 European ancestry controls
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy)
12,550 European and unknown ancestry chronic obstructive pulmonary disease cases, 46,368 European and unknown ancestry controls, 144,793 European ancestry high blood pressure cases, 313,761 European ancestry controls
Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy)
12,550 European and unknown ancestry chronic pulmonary obstructive disease cases, 60,801 European and unknown ancestry coronary artery disease cases, 169,872 European and unknown ancestry controls
Chronic obstructive pulmonary disease or stroke (pleiotropy)
12,550 European and unknown ancestry chronic obstructive pulmonary disease cases, 46,368 European and unknown ancestry controls, 40,585 European ancestry stroke cases, 406,111 European ancestry controls
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy)
12,550 European and unknown ancestry chronic obstructive pulmonary disease cases, 46,368 European and unknown ancestry controls, 458,969 European ancestry individuals
200,680 European American individuals, 56,495 African American individuals, 14,112 Latino American individuals, 1,366 East Asian American individuals, 189 South Asian American individuals
34,658 European American cases, 167,346 European American controls, 17,267 African American cases, 39,381 African American controls, 3,449 Latino American cases, 10,726 Latino American controls, 164 East Asian American cases, 1,210 East Asian American controls, 46 South Asian American cases, 144 South Asian American controls
11,130 Japanese ancestry cases, 187,639 Japanese ancestry controls
2,289 Japanese ancestry cases, 3,817 Japanese ancestry controls
1,036 Indian ancestry individuals
4,235 Indian ancestry individuals, 188,577 European ancestry individuals, 7,898 East Asian, South Asian and African ancestry individuals
Plasma norclozapine levels in treatment-resistant schizophrenia
2,989 European ancestry individuals
Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia
Plasma clozapine levels in treatment-resistant schizophrenia
Diarrhoea-associated Entamoeba histolytica infection
170 Bangladeshi ancestry cases, 574 Bangladeshi ancestry controls
992 European ancestry cases, 2,910 European ancestry controls
Anti-Mullerian hormone levels in pre-menopausal women of late reproductive age
3,344 European ancestry women
Worry/vulnerability (special factor of neuroticism)
270,059 British ancestry individuals
Anxiety/tension (special factor of neuroticism)
General factor of neuroticism
Breast cancer specific mortality in breast cancer
7,697 European ancestry cases, 88,964 European ancestry controls
Affymetrix, Illumina [~ 10400000] (imputed)
Breast cancer specific mortality in estrogen receptor negative breast cancer
2,125 European ancestry cases, 14,047 European ancestry controls
Breast cancer specific mortality in estrogen receptor positive breast cancer
4,116 European ancestry cases, 60,055 European ancestry controls
Response to intravenous immunoglobulin treatment in Kawasaki disease
101 Korean ancestry non-responder cases, 195 Korean ancestry responder cases
216 East Asian ancestry non-responder cases, 1,026 East Asian responder cases
8,736 European ancestry individuals, 1,541 East Asian ancestry individuals, 445 Hispanic ancestry individuals, 847 African-American ancestry individuals
Lumbar spine bone mineral density (trabecular)
12,287 European ancestry individuals
2,987 individuals
Affymetrix, Illumina [up to 37790451] (imputed)
Lumbar spine bone mineral density (integral)
11,080 European ancestry individuals
Affymetrix, Illumina [up to 2659730] (imputed)
15,910 European ancestry cases, 408,571 European ancestry controls
1,504 European ancestry cases, 296 Black African ancestry cases, 668 Afro-Caribbean ancestry cases, 203 Indian ancestry cases, 20,133 European ancestry controls, 1,256 Black African ancestry controls, 2,041 Afro-Caribbean ancestry controls, 2,567 Indian ancestry controls
180,129 European ancestry cases, 180,709 European ancestry controls
4,235 African American Afro-Caribbean cases, 5,283 African American Afro-Caribbean controls, 2774 Hispanic cases, 2,362 Hispanic controls
Affymetrix, Illumina [23328733] (imputed)
Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer
634 European ancestry individuals, 40 African ancestry individuals, 13 Asian ancestry individuals
367 East Asian ancestry cases
758 East Asian ancestry cases
Tinnitus in cisplatin-treated testicular cancer
154 European ancestry cases, 608 European ancestry controls
Tramadol metabolism (O-desmethyltramadol to tramadol ratio)
37 Finnish ancestry deceased individuals
99 Finnish ancestry individuals
85,449 European ancestry individuals
5,819 European ancestry individuals
Sleep duration (variability)
84,441 European ancestry individuals
Sleep efficiency
84,810 European ancestry individuals
Sleep (number of episodes)
4,401 European ancestry individuals
Sleep (time to least active 5 hours)
85,205 European ancestry individuals
Time to most active 10 hours
85,670 European ancestry individuals
Sleep (time to midpoint)
Diurnal inactivity
84,757 European ancestry individuals
Perceptual rivalry (Necker cube stimulus)
1,880 Han Chinese ancestry individuals
748 Han Chinese ancestry individuals
Perceptual rivalry (voluntary modulation strength)
1,876 Han Chinese ancestry individuals
744 Han Chinese ancestry individuals
Perceptual rivalry (binocular rivalry task)
2,097 Han Chinese ancestry individuals
870 Han Chinese ancestry individuals
Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect)
Up to 4,475 European ancestry individuals
Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect)
Up to 2,921 European ancestry individuals
Estimated glomerular filtration rate after 5 years in renal transplantation (donor effect)
Estimated glomerular filtration rate change in renal transplantation (recipient effect)
Up to 2,298 European ancestry individuals
Estimated glomerular filtration rate change in renal transplantation (donor effect)
Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect)
Up to 5,935 European ancestry individuals
11,156 African American individuals, 4,758 African ancestry individuals
Systolic blood pressure x sodium interaction (1df test)
4,527 Japanese ancestry individuals
4,241 Japanese ancestry individuals
Diastolic blood pressure x sodium interaction (1df test)
Blood pressure x alcohol consumption interaction
1,764 East Asian ancestry alcohol-drinking individuals, 14,779 East Asian ancestry non-alcohol-drinking individuals
Blood pressure (smoking interaction)
4,104 East Asian ancestry smoking individuals, 12,429 East Asian ancestry non-smoking individuals
Anhedonia in major depressive disorder
759 European ancestry individuals
1,351 individuals
37,857 European or East Asian cases, 227,116 European or East Asian controls
147,200 European ancestry cases, 150,085 European ancestry controls
Affymetrix, Illumina [2539801] (imputed)
37,857 European or East Asian ancestry cases, 227,116 European or East Asian ancestry controls
18,779 European, East Asian or other ancestry cases, 32,078 European, East Asian or other ancestry controls
Cannabis use
184,765 European ancestry individuals
Affymetrix, Illumina [11733371] (imputed)
868 European ancestry cases, 1,194 European ancestry controls
Sexual/religious dimension in obsessive compulsive disorder
95 European ancestry cases, 280 European ancestry controls
Brain-derived neurotrophic factor levels
11,785 European ancestry individuals
Affymetrix, Illumina [9950208] (imputed)
Brain morphology (MOSTest)
26,502 European ancestry individuals
Cortical thickness (MOSTest)
Subcortical volume (MOSTest)
Brain morphology (min-P)
Cortical surface area (MOSTest)
Subcortical volume (min-P)
Cortical surface area (min-P)
Cortical thickness (min-P)
Skin reflectance (Melanin index)
720 South Asian ancestry individuals
Affymetrix, Illumina [at least 398118] (imputed)
Iris color (a* coordinate)
329 South Asian ancestry individuals
Iris color (b* coordinate)
Iris color (L* coordinate)
Iris heterochromicity
Morning person
252,287 European ancestry cases, 150,908 European ancestry controls
120,478 European ancestry cases, 127,622 European ancestry controls
Chronotype
449,734 European ancestry individuals
248,098 European ancestry individuals
Visceral fat
1589 French-Canadian ancestry individuals
11,864 European ancestry cases, 1,016 Hispanic cases, 938 East Asian ancestry cases, 397 African American cases, 17,995 European ancestry controls, 1,954 Hispanic controls, 1,799 East Asian ancestry controls, 686 African American controls
2,783 European ancestry cases, 70 South Asian ancestry cases, 68 African British cases, 2 East Asian ancestry cases, 36 mixed and unknown ancestry cases, 206,975 European ancestry controls, 5,234 South Asian ancestry controls, 3,566 African British controls, 678 East Asian ancestry controls, 3,626 mixed and unknown ancestry controls
1,908 Han Chinese ancestry individuals
10,401 African ancestry individuals
Extremely high intelligence
1,247 European ancestry cases, 86,493 European ancestry controls
92,340 European ancestry individuals
Affymetrix, Illumina [2712613] (imputed)
Response to selective serotonin reuptake inhibitors in depression
257 Taiwanese ancestry responders, 164 Taiwanese ancestry non-responders
Remission after SSRI treatment in major depression
139 Taiwanese ancestry remitted cases, 282 Taiwanese ancestry non-remitted cases
Diffusing capacity of the lung for carbon monoxide traits
8,372 European ancestry individuals
347 Metropolitan French ancestry cases, 653 Metropolitan French ancestry controls
Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG seropositivity
914 Metropolitan French ancestry cases, 86 Metropolitan French ancestry controls
Anti-Epstein-Barr virus viral capsid antigen (VCA) IgG seropositivity
956 Metropolitan French ancestry cases, 44 Metropolitan French ancestry controls
Anti-Epstein-Barr virus early antigen (EA) IgG seropositivity
91 Metropolitan French ancestry cases, 909 Metropolitan French ancestry controls
645 Metropolitan French ancestry cases, 355 Metropolitan French ancestry controls
208 Metropolitan French ancestry cases, 792 Metropolitan French ancestry controls
931 Metropolitan French ancestry cases, 69 Metropolitan French ancestry controls
175 Metropolitan French ancestry cases, 825 Metropolitan French ancestry controls
559 Metropolitan French ancestry cases, 441 Metropolitan French ancestry controls
Anti-influenza A virus IgG seropositivity
777 Metropolitan French ancestry cases, 223 Metropolitan French ancestry controls
Anti-measles virus IgG seropositivity
885 Metropolitan French ancestry cases, 115 Metropolitan French ancestry controls
Anti-mumps virus IgG seropositivity
912 Metropolitan French ancestry cases, 88 Metropolitan French ancestry controls
Anti-rubella virus IgG seropositivity
935 Metropolitan French ancestry cases, 65 Metropolitan French ancestry controls
Anti-hepatitis B virus surface antigen (HBs) IgG seropositivity
508 Metropolitan French ancestry cases, 492 Metropolitan French ancestry controls
Anti-hepatitis B virus core antigen (HBc) IgG seropositivity
15 Metropolitan French ancestry cases, 985 Metropolitan French ancestry controls
1000 Metropolitan French ancestry individuals
IgE levels
Anti-cytomegalovirus IgG levels
347 Metropolitan French ancestry individuals
914 Metropolitan French ancestry individuals
956 Metropolitan French ancestry individuals
Anti-Epstein-Barr virus early antigen (EA) IgG levels
91 Metropolitan French ancestry individuals
Anti-herpes simplex virus 1 IgG levels
645 Metropolitan French ancestry individuals
Anti-herpes simplex virus 2 IgG levels
208 Metropolitan French ancestry individuals
Anti-varicella zoster virus IgG levels
931 Metropolitan French ancestry individuals
Anti-helicobacter pylori IgG levels
175 Metropolitan French ancestry individuals
Anti-Toxoplasma gondii IgG levels
559 Metropolitan French ancestry individuals
Anti-influenza A virus IgG levels
777 Metropolitan French ancestry individuals
Anti-measles virus IgG levels
885 Metropolitan French ancestry individuals
Anti-mumps virus IgG levels
912 Metropolitan French ancestry individuals
Anti-rubella virus IgG levels
935 Metropolitan French ancestry individuals
Anti-hepatitis B virus surface antigen (HBs) IgG levels
508 Metropolitan French ancestry individuals
Anti-hepatitis B virus core antigen (HBc) IgG levels
15 Metropolitan French ancestry individuals
Hashimoto thyroiditis
405 Croatian ancestry cases, 433 Croatian ancestry controls
303 Croatian ancestry cases, 302 Croatian ancestry controls
Nonsyndromic cleft lip with or without cleft palate x sex interaction (2df test)
1,293 male cases, 849 female cases, 713 male controls, 987 female controls
Developmental dysplasia of the hip
770 European ancestry cases, 3,364 European ancestry controls
1,129 European ancestry cases, 4,652 European ancestry controls
Thyroid nodules
811 Korean ancestry cases, 691 Korean ancestry controls
1,981 Korean ancestry cases, 3,100 Korean ancestry controls
343,321 British ancestry individuals
Acute lymphoblastic leukemia (childhood)
203 Hispanic cases and 96 Native American cases from 323 families
Radiation-induced brain injury in nasopharyngeal carcinoma
243 cases, 839 controls
438 cases, 1,422 controls
16,902 European ancestry Crohn's disease cases, 12,597 European ancestry ulcerative colitis cases, 339 European ancestry cases
2,453 European ancestry Crohn's disease cases, 3,729 European ancestry ulcerative colitis cases
Lung cancer in ever smokers
4,628 European ancestry cases, 4,041 European ancestry controls
16,341 European ancestry cases, 9,930 European ancestry controls
Lung cancer (SNP x SNP interaction)
4,918 European ancestry cases, 5,555 European ancestry controls
18,439 European ancestry cases, 14,026 European ancestry controls
Upper eyelid sagging severity
6,631 European ancestry individuals
Guillain-Barré syndrome
191 European ancestry cases, 639 European ancestry controls
Response to opioid analgesics in cancer (pain decrease)
71 Japanese ancestry individuals
833 Han Chinese ancestry cases, 1,220 Han Chinese ancestry controls
2,116 Han Chinese ancestry cases, 3,870 Han Chinese ancestry controls
Total hippocampal volume
21,297 European ancestry individuals
Presubiculum volume (corrected for total hippocampal volume)
Subiculum volume (corrected for total hippocampal volume)
Hippocampal subfield CA1 volume (corrected for total hippocampal volume)
Hippocampal subfield CA3 volume (corrected for total hippocampal volume)
Hippocampal subfield CA4 volume (corrected for total hippocampal volume)
Dentate gyrus granule cell layer volume (corrected for total hippocampal volume)
Dentate gyrus molecular layer volume (corrected for total hippocampal volume)
Hippocampal fissure volume (corrected for total hippocampal volume)
Hippocampal tail volume (corrected for total hippocampal volume)
Fimbria volume (corrected for total hippocampal volume)
HATA volume (corrected for total hippocampal volume)
Parasubiculum volume (corrected for total hippocampal volume)
Presubiculum volume
Subiculum volume
Hippocampal subfield CA1 volume
Hippocampal subfield CA3 volume
Hippocampal subfield CA4 volume
Dentate gyrus granule cell layer volume
Dentate gyrus molecular layer volume
Hippocampal fissure volume
Hippocampal tail volume
Fimbria volume
HATA volume
Parasubiculum volume
Vestibular neuritis
131 European ancestry cases, 2,609 German ancestry controls
Affymetrix, Illumina [7813927] (imputed)
Eye movement (horizontal position gain)
166 Japanese ancestry individuals
Eye movement in schizophrenia (scanpath length)
60 Japanese ancestry cases
60 Japanese ancestry schizophrenia cases, 166 Japanese ancestry controls
Eye movement (scanpath length)
Eye movement in schizophrenia (duration of fixations)
Eye movement (duration of fixations)
Eye movement in schizophrenia (integrated eye movement score)
Eye movement (integrated eye movement score)
Eye movement in schizophrenia (horizontal position gain)
296 Korean ancestry cases, 1,000 Korean ancestry controls
2,666 East Asian ancestry cases, 10,446 East Asian ancestry controls
Major depressive disorder (probable)
30,603 British ancestry cases, 143,916 British ancestry controls
Major depressive disorder (ICD-10 coded)
8,276 British ancestry cases, 209,308 British ancestry controls
Depression (broad)
113,769 British ancestry cases, 208,811 British ancestry controls
Takayasu arteritis
305 Turkish ancestry cases, 106 European ancestry cases, 483 Turkish ancestry controls, 553 European ancestry controls
Healthspan
300,447 British ancestry individuals
81,099 European ancestry individuals, 3,073 African ancestry individuals, 6,921 South Asian ancestry individuals, 1,422 Chinese ancestry individuals, 3,799 Caribbean individuals
61,714 European ancestry cases, 1,178 Pakistani ancestry cases, 593,952 European ancestry controls, 2,472 Pakistani ancestry controls
21,147 European ancestry cases, 434,460 European ancestry controls
Affymetrix, Illumina [up to 40000000] (imputed)
11,018 European ancestry cases, 126,068 European ancestry controls
Bronchodilator response in asthma
949 African American cases, 1,830 Latino cases
1,615 African American cases, 416 Latino cases
Uterine fibroid number (single vs multiple)
636 African American or European ancestry female individuals with single fibroid, 822 African American or European ancestry female individuals with multiple fibroids
Uterine fibroid size (maximum dimension)
1,301 African American or European ancestry female individuals
Uterine fibroid size (maximum volume)
1,048 African American or European ancestry female individuals
High IL-1beta levels in gingival crevicular fluid
4,910 European American individuals
Anthropometric traits (multi-trait analysis)
4,988 Spanish ancestry individuals
336,107 British ancestry individuals
Anthropometric traits
Disorders of lipid metabolism
Eye color traits
Skin pigmentation traits
Hair morphology traits
Handedness
Brain imaging measurements
8,428 British ancestry individuals
4,386 European ancestry individuals
Body size at age 10
453,169 European ancestry individuals
Adult body size
Small subcortical brain infarct
1,715 European ancestry cases, 187 African American cases, 56 Hispanic ancestry cases, 23 Chinese ancestry cases, 40 Malay ancestry cases, 13,749 European ancestry controls, 807 African American controls, 643 Hispanic ancestry controls, 173 Chinese ancestry controls, 168 Malay ancestry controls
630 European ancestry cases, 5,118 European ancestry controls
Affymetrix, Illumina [6824387] (imputed)
Brain infarct
3,149 European ancestry cases, 402 African American cases, 94 Hispanic ancestry cases, 34 Chinese ancestry cases, 47 Malay ancestry cases, 14,807 European ancestry controls, 1,432 African American controls, 643 Hispanic ancestry controls, 173 Chinese ancestry controls, 168 Malay ancestry controls
1,223 European ancestry cases, 260 Japanese ancestry cases, 5,118 European ancestry controls, 261 Japanese ancestry controls
Affymetrix, Illumina [7423334] (imputed)
4,102 European ancestry cases, 8,489 European ancestry controls
993 European ancestry cases, 1,419 European ancestry controls
Affymetrix, Illumina [1722107] (imputed)
Life satisfaction
80,852 European ancestry individuals
Positive affect
410,603 European ancestry individuals
523,783 European ancestry individuals
59,206 European ancestry individuals
1,067,913 European ancestry individuals
228,033 European ancestry individuals
Well-being spectrum (multivariate analysis)
2,083,151 European ancestry individuals
287,239 European ancestry individuals
Infantile hypertrophic pyloric stenosis
1,395 Danish ancestry cases, 4,438 Danish ancestry controls
1,794 European ancestry cases, 633 Hispanic ancestry cases, 1,875 European ancestry controls, 633 Hispanic ancestry controls
Prostate cancer mortality
245 European ancestry lethal cases, 808 European ancestry long-term survivor cases
172 European ancestry lethal cases, 1380 European ancestry long-term survivor cases
Serum erythropoietin levels
2,994 Icelandic ancestry individuals, 1,193 non-array typed, familial imputed Icelandic ancestry individuals
68 Icelandic ancestry individuals
Cholesteryl ester transfer protein levels
4248 individuals
1458 individuals
2153 Mexican ancestry individuals
Socioeconomic status of place of residence
456,426 European ancestry individuals
Population density of place of residence
504,130 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 12272635] (imputed)
Type 2 diabetes or coronary artery disease (pleiotropy)
12,171 European ancestry type 2 diabetes cases, 22,233 European ancestry coronary artery disease cases, 121,624 European ancestry controls
6,171 Japanese ancestry cases, 27,178 Japanese ancestry controls
5,336 Japanese ancestry cases, 11,726 Japanese ancestry controls
Response to TNF inhibitor in rheumatoid arthritis (erythrocyte sedimentation rate)
487 European ancestry individuals treated with adalimumab, 549 European ancestry individuals treated with etanercept, 414 European ancestry individuals treated with infliximab, 64 European ancestry individuals treated with other TNF inhibitors
Affymetrix, Illumina [9814288] (imputed)
Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count)
551 European ancestry individuals treated with adalimumab, 619 European ancestry individuals treated with etanercept, 434 European ancestry individuals treated with infliximab, 119 European ancestry individuals treated with other TNF inhibitors
Response to TNF inhibitor in rheumatoid arthritis (change in patient global heath assessment score)
549 European ancestry individuals treated with adalimumab, 615 European ancestry individuals treated with etanercept, 426 European ancestry individuals treated with infliximab, 119 European ancestry individuals treated with other TNF inhibitors
Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count)
Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score)
500 European ancestry individuals treated with adalimumab, 564 European ancestry individuals treated with etanercept, 441 European ancestry individuals treated with infliximab, 64 European ancestry individuals treated with other TNF inhibitors
84,847 European ancestry cases, 241,266 European ancestry controls, 5,303 Han Chinese ancestry cases, 5,337 Han Chinese ancestry controls
2,659 European ancestry cases, 17,237 European ancestry controls
Affymetrix, Illumina [at least 1235109] (imputed)
Eudaimonic well-being
108,154 British ancestry individuals
Hedonic well-being
221,575 British ancestry individuals
Myopic maculopathy
4,476 Japanese ancestry individuals
3,279 Japanese ancestry individuals
Genome-wide genotyping array, Exome genotyping array
Shingles
3,201 European ancestry cases, 34,960 European ancestry controls, 398 African American cases, 5,922 African American controls, 756 Asian ancestry individuals
Affymetrix, Illumina [39127678] (imputed)
8,197 European ancestry cases, 241,468 European ancestry controls
1,777 European ancestry cases, 6,088 European ancestry controls
Alzheimer's disease (SNP x SNP interaction)
788 male cases, 1,455 female cases, 2,362 male controls, 3,655 female controls
3,836 male cases, 6,244 female cases, 8,618 male controls, 11,624 female controls
16,624 European ancestry individuals
4,443 African ancestry individuals
Initial alcohol sensitivity
6,039 European ancestry individuals, 892 African ancestry individuals, 408 American ancestry individuals
Affymetrix, Illumina [15642250] (imputed)
84,847 European ancestry cases, 241,266 European ancestry controls
45,773 European ancestry cases, 106,354 European ancestry controls
Response to lurasidone in schizophrenia
264 European ancestry cases, 158 African American ancestry cases
1,238 European ancestry cases, 8,172 European ancestry controls
Longevity
564 Han Chinese ancestry male centenarian cases, 1,614 Han Chinese ancestry female centenarian cases, 773 Han Chinese ancestry male middle-aged controls, 1,526 Han Chinese ancestry female middle-aged controls
Waldenström macroglobulinemia / lymphoplasmacytic lymphoma
217 European ancestry cases, 3,798 European ancestry controls
313 European ancestry cases, 564 European ancestry controls
Psoriasis
2,280 cases, 2,002 controls
Pulmonary function (FEV1) x omega-3 PUFA (docosapentaenoic acid) interaction (2df)
11,165 European ancestry individuals, 797 African ancestry individuals
1,141 European ancestry individuals, 546 African ancestry individuals
Affymetrix, Illumina [7200000] (imputed)
Pulmonary function (FVC) x omega-3 PUFA (docosapentaenoic acid) interaction (2df)
Pulmonary function (FVC) x omega-3 PUFA (docosahexaenoic acid) interaction (2df)
Pulmonary function (FEV1) x omega-3 PUFA (docosahexaenoic acid) interaction (2df)
8,832 Korean ancestry individuals
Adolescent idiopathic scoliosis
196 cases, 303 controls
Response to platinum-based chemotherapy in non-small-cell lung cancer (progression)
181 European ancestry individuals
356 European ancestry individuals
Type 2 diabetes (SNP x SNP interaction, 2df)
2,452 African American cases, 3,772 African American controls
Type 2 diabetes (SNP x SNP interaction, 1df)
Femoral neck size
28,954 European ancestry individuals
9,383 European ancestry individuals, 6,351 East Asian ancestry individuals
Trochanter size
28,944 European ancestry individuals
8,065 European ancestry individuals, 5,711 East Asian ancestry individuals
Intertrochanteric region size
28,936 European ancestry individuals
7,912 European ancestry individuals, 5,696 East Asian ancestry individuals
Spine bone size
29,059 European ancestry individuals
14,932 European ancestry individuals, 6,345 East Asian ancestry individuals
28,900 European ancestry individuals
7,912 European ancestry individuals, 5,699 East Asian ancestry individuals
Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis
405 European ancestry cases
Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis
Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis
Renal cell carcinoma
1,992 European ancestry female cases, 3,095 European ancestry female controls
1,399 European ancestry female cases, 1,575 European ancestry female controls
Renal cell carcinoma x sex interaction
3,227 European ancestry male cases, 1,992 European ancestry female cases, 4,916 European ancestry male controls, 3,095 European ancestry female controls
2,261 European ancestry male cases, 5,852 European ancestry male controls, 1,399 European ancestry female cases, 1,575 European ancestry female controls
3,227 European ancestry male cases, 4,916 European ancestry male controls
2,261 European ancestry male cases, 5,852 European ancestry male controls
Irritable bowel syndrome
7,130 British ancestry women cases, 2,446 British ancestry men cases, 178,076 British ancestry women controls, 158,423 British ancestry men controls
Global electrical heterogeneity phenotypes
3,057 Black individuals, 10,769 European ancestry individuals
Affymetrix, Illumina [at least 9117794] (imputed)
Nontyphoidal Salmonella bacteraemia
180 Kenyan ancestry cases, 2,677 Kenyan ancestry controls
171 Sub-Saharan African ancestry cases, 563 Sub-Saharan African ancestry controls
Endometriosis or endometrial cancer (pleiotropy)
3,194 endometriosis cases, 5,330 non-endometriosis controls, 2,057 endometrial cancer cases, 3,866 non-endometrial cancer controls
Depression in smokers
1,622 European ancestry cases, 391 African American cases, 4,954 European ancestry controls, 2,749 African American controls
Tourette syndrome or brain region volumes (pleiotropy)
4,644 European ancestry Tourette syndrome cases, 8,695 European ancestry Tourette syndrome controls, 30,717 European ancestry individuals with subcortical brain volume measurements
Social disinhibition in Tourette syndrome or subcortical volume measurements (pleiotropy)
1,414 European ancestry Tourette syndrome cases with social disinhibition measurements, 30,717 European ancestry individuals with subcortical brain volume measurements
Symmetry behaviour in Tourette syndrome or subcortical volume measurements (pleiotropy)
1,419 European ancestry Tourette syndrome cases with symmetry behaviour measurements, 30,717 European ancestry individuals with subcortical brain volume measurements
13,962 European ancestry cases, 300,671 European ancestry controls
31,759 European ancestry cases, 214,890 European ancestry controls
26,582 European ancestry cases, 300,671 European ancestry controls
16,297 European ancestry cases, 217,711 European ancestry controls
40,544 European ancestry cases, 300,671 European ancestry controls
Asthma onset (childhood vs adult)
13,962 European ancestry childhood onset cases, 14,873 European ancestry adult onset cases
31,002 European ancestry childhood onset cases, 16,297 European ancestry adult onset cases
Fasting blood insulin adjusted for BMI
up to 30,825 non-diabetic individuals
Fasting blood glucose adjusted for BMI
up to 33,231 non-diabetic individuals
606 Japanese ancestry cases, 1,040 Japanese ancestry controls
2,517 Japanese ancestry cases, 885 Japanese ancestry controls
Hyperuricemia
847 Japanese ancestry cases, 4,640 Japanese ancestry controls
972 Japanese ancestry cases, 4,584 Japanese ancestry controls
5,847 Japanese ancestry individuals
5,636 Japanese ancestry individuals
29 French ancestry individuals with grade 0-I sagging, 107 French ancestry individuals with grade II sagging, 192 French ancestry individuals with grade III sagging, 174 French ancestry individuals with grade IV-V sagging
Low white blood cell count
783 African American individuals with low white blood cell count, 1,214 African American individuals with high white blood cell count
Low white blood cell count (conditioned on rs2814778)
592 African American individuals with low white blood cell count, 586 African American individuals with high white blood cell count
Warfarin-associated bleeding
31 African American cases, 184 African American controls
40 African American cases, 148 African American controls
Cardiac Troponin-T levels
10,395 European ancestry individuals
Cardiac troponin-I levels
14,579 European ancestry individuals
Anhedonia
4,937 European ancestry individuals, 821 European ancestry sibling pairs
1,089 European ancestry individuals, 635 European ancestry monozygotic twin pairs
Affymetrix, Illumina [4487870] (imputed)
Cognitive disorganisation
1,981 European ancestry individuals, 2,158 European ancestry sibling pairs
Parent-rated negative symptoms
5,642 European ancestry individuals, 2,228 European ancestry sibling pairs
Paranoia and hallucinations
5,313 European ancestry individuals, 1,676 European ancestry sibling pairs
3,595 Mexican American ancestry individuals
1,577 Mexican American ancestry individuals
3,644 Mexican American ancestry individuals
Plantar fascial disorders
17,627 European ancestry cases, 2,044 Latin American cases, 1,300 East Asian cases, 658 African American cases, 65,637 European ancestry controls, 6,516 Latin American controls, 6,218 East Asian controls, 2,508 African American controls
Ventricular ectopy or supraventricular ectopy (pleiotropy)
1,618 European ancestry supraventricular ectopy cases, 652 African ancestry supraventricular ectopy cases, 354 Hispanic/Latino ancestry supraventricular ectopy cases, 2,468 European ancestry ventricular ectopy cases, 481 African ancestry ventricular ectopy cases, 168 Hispanic/Latino ancestry ventricular ectopy cases, at least 19,586 European ancestry controls, at least 8,141 African ancestry controls, at least 10,663 Hispanic/Latino ancestry controls.
Ventricular ectopy
2,468 European ancestry cases, 21,204 European ancestry controls, 481 African ancestry cases, 8,793 African ancestry controls, 168 Hispanic/Latino ancestry cases, 11,017 Hispanic/Latino ancestry controls
Supraventricular ectopy
1,618 European ancestry cases, 20,899 European ancestry controls, 652 African ancestry cases, 8,622 African ancestry controls, 354 Hispanic/Latino ancestry cases, 10,831 Hispanic/Latino ancestry controls
731 Japanese ancestry individuals
560 Japanese ancestry individuals
Multiple traits (pleiotropy)
1,787 European ancestry ankylosing spondylitis cases, 9,772 European ancestry multiple sclerosis cases, 2,178 European ancestry psoriasis cases, 2,361 European ancestry ulcerative colitis cases, 844 European ancestry large vessel ischemic stroke cases, 580 European ancestry small vessel ischemic stroke cases, 790 European ancestry cardioembolic ischemic stroke cases, 2,794 European ancestry individuals with reading score and mathematics score measurements, 1,606 European ancestry schizophrenia cases, 1,239 European ancestry psychosis cases, 1,705 European ancestry Parkinson's disease cases, 1,852 European ancestry Barrett's esophagus cases, 1,024 European ancestry individuals with metformin response measurements, 2,302 European ancestry glaucoma cases, 429 Kenyan ancestry pneumococcal bacteremia cases, 1,107 Kenyan ancestry other bacteremia cases, 357 Brazilian ancestry visceral leishmaniasis cases, 989 Indian ancestry visceral leishmaniasis cases, 23,008 European ancestry controls, 2,677 Kenyan ancestry controls, 1,613 Brazilian ancestry controls, 1,089 Indian ancestry controls
Affymetrix, Illumina [2058911] (imputed)
215 Egyptian ancestry cases, 416 Egyptian ancestry controls
321 Egyptian ancestry cases, 253 Egyptian ancestry controls
Growth differentiation factor-15 levels
3,889 European ancestry individuals
434 European ancestry cases with coronary artery disease, 3,123 European ancestry cases without coronary artery disease
585 cases with coronary artery disease, 2,612 cases without coronary artery disease
Growth differentiation factor-15 levels (conditioned on rs888663)
4,633 European ancestry individuals
807 European ancestry individuals
Thyrotoxic hypokalemic periodic paralysis in Graves disease
171 Han Chinese ancestry cases with TPP, 1,404 Han Chinese ancestry cases without TPP
Thyrotoxic hypokalemic periodic paralysis and Graves disease
171 Han Chinese ancestry cases, 2,160 Han Chinese ancestry controls
362 Han Chinese ancestry cases, 1,089 Han Chinese ancestry controls
5,786 Chinese ancestry individuals
6,943 Chinese ancestry individuals
748 Chinese ancestry cases, 4,983 Chinese ancestry controls
218,759 European ancestry individuals
109,530 European ancestry individuals
Urinary potassium to creatinine ratio
218,435 European ancestry individuals
109,178 European ancestry individuals
Urinary sodium to creatinine ratio
218,450 European ancestry individuals
109,166 European ancestry individuals
Urinary sodium to potassium ratio
217,996 European ancestry individuals
108,942 European ancestry individuals
Albuminuria
217,634 European ancestry individuals
108,800 European ancestry individuals
Severe coronary artery calcification
100 Korean ancestry cases, 300 Korean ancestry controls
227 Korean ancestry cases, 1,061 Korean ancestry controls
Resting-state electroencephalogram vigilance
1,877 European ancestry individuals
290,891 European ancestry individuals
27,865 European ancestry individuals
Affymetrix, Illumina [at least 560000] (imputed)
Systemic lupus erythematosus
6,748 European ancestry cases, 11,516 European ancestry controls
6,748 European ancestry cases, 11,516 European ancestry controls, 2,970 African American cases, 2,452 African American controls, 1,872 Hispanic cases, 2,016 Hispanic controls
Vision loss in proton beam irradiation treatment of choroidal melanoma
50 treated cases, 76 treated controls
Clostridium difficile infection in multiple myeloma
57 European ancestry cases, 589 European ancestry controls
Idiopathic intracranial hypertension
63 European ancestry cases, 21 African American cases, 4 Native American cases, 1 Asian cases, 6 cases, 61 European ancestry controls, 21 African American controls, 3 Native American controls, 1 Asian controls, 9 controls
Coronary heart disease events during statin therapy
3,088 European ancestry cases, 11 cases, 7,587 European ancestry controls, 94 controls
139 European ancestry cases, 21 cases, 990 European ancestry controls, 122 controls
Soluble E-selectin levels
5,284 Finnish ancestry individuals
Soluble ICAM-1
Soluble VCAM-1 levels
Interleukin-1-alpha levels
Soluble CD40 ligand levels
13,577 Finnish ancestry individuals
Interleukin-17 levels
Interleukin-1-beta levels
Interleukin-4 levels
Interferon gamma-induced protein 10 levels
Response to SSRI in MDD or conscientiouness
865 individuals with SSRI response data, 260,861 individuals with personality trait data
Remission after SSRI treatment in MDD or neuroticism
865 individuals with SSRI response data, 170,911 individuals with personality trait data
Remission after SSRI treatment in MDD or openness
Response to SSRI in MDD or openness
Change in serum uric acid levels in response to thiazide diuretic treatment (hydrochlorothiazide) in hypertension
214 Finnish cases
465 Finnish cases
Aortic coarctation
39 Icelandic ancestry cases, 140,661 Icelandic ancestry controls
81 Icelandic ancestry cases, 214,412 Icelandic ancestry controls
Lipid traits (pleiotropy) (HIPO component 1)
188,577 European ancestry individuals
Lipid traits (pleiotropy) (HIPO component 2)
Social science traits (pleiotropy) (HIPO component 1)
up to 630,791 European ancestry individuals
Psychiatric diseases (pleiotropy) (HIPO component 1)
4,949 autism cases, 2787 ADHD cases, 6,990 bipolar disorder cases, 9,227 depression cases, 9,379 schizophrenia cases, 27,888 controls
Osteoarthritis (self-reported)
12,658 European ancestry cases, 50,898 European ancestry controls
Osteoarthritis of the hip (hospital diagnosed)
2,396 European ancestry cases, 9,593 European ancestry controls
5,714 Icelandic ancestry cases, 199,421 Icelandic ancestry controls
Osteoarthritis (hospital diagnosed)
10,083 European ancestry cases, 40,425 European ancestry controls
18,069 Icelandic ancestry cases, 246,293 Icelandic ancestry controls
Osteoarthritis of the knee (hospital diagnosed)
4,462 European ancestry cases, 17,885 European ancestry controls
4,672 Icelandic ancestry cases, 172,791 Icelandic ancestry controls
Osteoarthritis of the hip or knee (hospital diagnosed)
6,586 European ancestry cases, 26,384 European ancestry controls
9,429 Icelandic ancestry cases, 199.421 Icelandic ancestry controls
Thrombocytopenia in coronary artery bypass surgery
176 European ancestry cases, 268 European ancestry cases
76 European ancestry cases, 70 European ancestry cases
Anorexia nervosa or obsessive-compulsive disorder
3,495 European ancestry anorexia nervosa cases, 2,688 European ancestry obsessive-compulsive disorder cases, 18,013 European ancestry controls
Biliary atresia
343 European ancestry cases, 1,716 European ancestry controls
156 European ancestry cases, 212 European ancestry controls
Response to tamoxifen in oestrogen receptor positive/HER2 negative breast cancer
275 East Asian ancestry individuals
72 East Asian or Asian ancestry individuals
Glomerular filtration rate change in heart transplantation
243 European ancestry individuals, 1 American Indian ancestry individual, 7 individuals
Philtrum width
6,136 European ancestry individuals
Nonsyndromic cleft lip with or without cleft palate
638 European ancestry trios, 178 European ancestry duos, 399 cases, 1,318 controls
Sudden cardiac arrest
up to 3,939 European ancestry cases, up to 25,989 European ancestry controls
up to 4,751 European ancestry cases, up to 35,582 European ancestry controls, 152 African American cases, 176 African American controls, 225 Asian American cases, 199 Asian American controls
Affymetrix, Illumina [at least 306655] (imputed)
Pediatric areal bone mineral density (concordant skeletal phenotype)
470 European ancestry females, 463 European ancestry males, 256 African and Asian ancestry females, 210 African and Asian ancestry males
238 European ancestry females, 246 European ancestry males
Pediatric areal bone mineral density (radius vs spine & hip discordant skeletal phenotype)
Pediatric areal bone mineral density (spine vs radius & hip discordant skeletal phenotype)
Cardiovascular disease in type 2 diabetes
326 Han Chinese ancestry cases, 1,209 Han Chinese ancestry controls
68 Han Chinese ancestry cases, 317 Han Chinese ancestry controls
215,551 European ancestry individuals, 57,332 African American individuals, 24,743 Hispanic individuals
Up to 319,677 individuals
LDL cholesterol
Primary biliary cholangitis
1,855 Japanese ancestry cases, 1,719 Japanese ancestry controls
2,385 Latina cases, 6,416 Latina controls
2,412 Latina cases, 1,580 Latina controls, 3,153 African American cases, 2,831 African American controls, 1,657 African, African American and West Indian cases, 2,029 African, African American and West Indian controls, 4,525 East Asian ancestry cases, 4,194 East Asian ancestry controls, European ancestry cases, European ancestry controls
Affymetrix, Illumina [at least 192795] (imputed)
Methadone dose in opioid dependence
344 Taiwanese ancestry cases
Bronchopulmonary dysplasia in preterm infants
136 European ancestry cases, 82 African American cases, 28 Hispanic cases, 41 European ancestry controls, 51 African American controls, 14 Hispanic controls
Obesity without metabolic disease
38 European ancestry cases, 32 European ancestry non-obese controls
Energy expenditure
5,461 European ancestry lean females, 2,726 European ancestry lean males, 6,563 European ancestry overweight or obese females, 4,020 European ancestry overweight or obese males.
Energy intake
Gemcitabine-induced early high-grade neutropenia in pancreatic cancer
294 European ancestry cases
Rumination (response to stress)
1,758 European ancestry individuals
Brooding (response to stress)
Reflection (response to stress)
Plasma factor VII activating protease levels
3,126 Swedish ancestry individuals
Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy
130 European ancestry non-Richardson's syndrome cases, 367 European ancestry Richardson's syndrome controls
Adverse response to antithyroid drugs in Graves disease
24 East Asian ancestry cases, 423 East Asian ancestry controls
45 East Asian ancestry cases, 137 East Asian ancestry controls
Attention deficit hyperactivity disorder symptom score
14,689 European ancestry adults, 14,776 children
Affymetrix, Illumina, Perlegen [2804754] (imputed)
Suicide attempt severity
2,439 European ancestry individuals, 3,881 African American individuals
9,382 European ancestry individuals, 1,488 African American individuals, 2,963 Latino individuals
60,620 European ancestry cases, 970,216 European ancestry controls
Voxel-wise structural brain imaging measurements
1,721 European ancestry adolescent individuals
6,932 British ancestry individuals
45 Maya ancestry cases, 47 Maya ancestry controls
Glioblastoma (age-stratified)
1,533 cases diagnosed below median age, 1,476 cases diagnosed at median age, 1,503 cases diagnosed above median age, 10,582 controls,
Midgestational cytokine/chemokine levels (maternal genetic effect)
790 Hispanic, European, Asian, South Asian or African American individuals
Neonatal cytokine/chemokine levels (maternal genetic effect)
Midgestational cytokine/chemokine levels (fetal genetic effect)
764 Hispanic, European, Asian, South Asian or African American individuals
Neonatal cytokine/chemokine levels (fetal genetic effect)
373 Han Chinese ancestry cases, 6,721 Han Chinese ancestry controls
385 Han Chinese ancestry cases, 7,445 Han Chinese ancestry controls
924 Sub-Saharan African ancestry individuals
371 Sub-Saharan African ancestry individuals
3,238 East Asian ancestry cases, 4,083 East Asian ancestry controls
Chronic central serous retinopathy
521 European ancestry cases, 3,577 European ancestry controls
Post bronchodilator percent predicted FEV1 in smoking
1,086 European ancestry COPD cases, 559 European ancestry controls
Post bronchodilator FEV1/FVC ratio in smoking
Progressive supranuclear palsy
1,646 European ancestry cases, 10,662 European ancestry controls
Severe aortic features in Marfan syndrome
51 European ancestry cases, 47 European ancestry controls
Severe cutaneous adverse drug reactions
68 Korean ancestry cases, 272 Korean ancestry controls
38 Korean ancestry cases, 152 Korean ancestry controls
Leisure-time exercise behaviour
1,789 Japanese ancestry physically active cases, 12,191 Japanese ancestry physically inactive controls
250 Japanese ancestry physically active cases, 1,786 Japanese ancestry physically inactive controls
Leisure-time exercise behaviour (age-stratified)
6,749 Japanese ancestry active and inactive individuals aged over 56, 7,231 Japanese ancestry active and inactive individuals aged under 56
1,129 Japanese ancestry active and inactive individuals aged over 56, 907 Japanese ancestry active and inactive individuals aged under 56
175 European ancestry schizophrenia cases, 155 European ancestry controls
358 European ancestry cases, 407,399 European ancestry controls
31,355 European ancestry cases, 377,103 European ancestry controls
4,462 European ancestry cases, 397,761 European ancestry controls
4,562 European ancestry cases, 382,756 European ancestry controls
Plasma parathyroid hormone levels
806 Korculan (founder/genetic isolate) individuals, 831 Vis (founder/genetic isolate) individuals, 959 Croatian ancestry individuals
612 Korean ancestry cases, 1,536 Korean ancestry controls
Waist-to-hip ratio adjusted for BMI (recessive genetic model)
288,492 European ancestry individuals, up to 15,687 African American individuals, up to 29,315 South Asian ancestry individuals, up to 6,800 East Asian ancestry individuals, up to 4,075 Hispanic ancestry individuals
132,177 European ancestry individuals
Waist-to-hip ratio adjusted for BMI (additive genetic model)
288,492 European ancestry individuals
up to 130,976 European ancestry men, up to 164,238 African American, South Asian, East Asian and Hispanic ancestry men
up to 62,500 European ancestry men
up to 130,976 European ancestry men
up to 157,516 European ancestry women, up to 180,131 African American, South Asian, East Asian and Hispanic ancestry women
up to 62,368 European ancestry women
up to 157,516 European ancestry women
Pemphigus vulgaris
101 Chinese ancestry cases, 844 Chinese ancestry controls
at least 56 Chinese ancestry cases, up to 996 Chinese ancestry controls
Pemphigus foliaceus
65 Chinese ancestry cases, 844 Chinese ancestry controls
at least 49 Chinese ancestry cases, up to 996 Chinese ancestry controls
1,832 European and unknown ancestry modified Rankin score 0-1 cases, 2,620 European and unknown ancestry modified Rankin score 2-6 cases
Affymetrix, Illumina [~ 8500000] (imputed)
6,165 European and unknown ancestry individuals
3-month functional outcome in lacunar ischaemic stroke (modified Rankin score)
992 European and unknown ancestry individuals
3-month functional outcome in non-lacunar ischaemic stroke (modified Rankin score)
3,991 European and unknown ancestry individuals
3,830 European and unknown ancestry modified Rankin score 0-2 cases, 2,335 European and unknown ancestry modified Rankin score 3-6 cases
1,021 African American cases, 2,928 African American controls
Warfarin maintenance dose (adjusted for clinical factors)
701 European ancestry individuals, 539 African American individuals
137 European Ancestry individuals, 330 African American individuals
315,347 European ancestry individuals, 8,322 Hispanic/Latino individuals, 7,290 East Asian ancestry individuals, 3,069 African American individuals, 459 South Asian ancestry individuals
431,743 European ancestry individuals, 9,275 South Asian ancestry individuals, 8,261 African British individuals, 1,822 East Asian ancestry individuals, 7,620 individuals
Affymetrix [at least 28613428] (imputed)
Electrocardiographic traits
17,873 European ancestry individuals, 12,749 Hispanic individuals, 5,408 African American individuals, 315 Chinese-American individuals
Affymetrix, Illumina [22000000] (imputed)
Shoulder impingement or rotator cuff tear
3,864 European ancestry shoulder impingement cases, 5,701 European ancestry rotator cuff tear cases, up to 614,568 European ancestry controls
Shoulder impingement
3,864 European ancestry cases, 208,258 European ancestry controls
1,248 European ancestry cases, 6,941 European ancestry controls
2,266 European ancestry cases, 2,568 European ancestry controls
8,429 European ancestry individuals, 2,797 European ancestry individuals with ischemic stroke
1,202 European ancestry individuals
Affymetrix, Illumina [at least 39131578] (imputed)
Skin hydration
100 Korean ancestry individuals
6861 European ancestry individuals
4298 European ancestry individuals
Affymetrix, Illumina [8509364] (imputed)
243 German ancestry cases, 1,285 German ancestry controls
Cognitive flexibility
2,589 African American individuals, 2,284 European ancestry individuals
General cognitive ability
up to 300,486 European ancestry individuals
Reaction time
330,069 European ancestry individuals
Photic sneeze reflex
874 Chinese ancestry cases, 2,543 Chinese ancestry controls
6,949 Korean ancestry individuals
6,000 Korean ancestry individuals
Femoral neck length
18,719 individuals
8,334 individuals
Affymetrix, Illumina [up to 2622085] (imputed)
Narrowest width of the femoral neck
Femoral neck section modulus
Femoral neck-shaft angle
1,940 Japanese ancestry cases, 7,408 Japanese ancestry controls
4,071 Japanese ancestry cases, 54,470 Japanese ancestry controls
14,023 East Asian ancestry cases, 33,640 European ancestry cases, 31,505 East Asian ancestry controls, 43,456 European ancestry controls
Psychological wellbeing index 1 (lack of subjective wellbeing and health)
up to 12,680 Korean ancestry individuals
Psychological wellbeing index 3 (fatigue and loss of appetite)
Psychological wellbeing index 12 (lack of enjoying daily life)
Psychological wellbeing (social role performance and self-confidence)
Psychological wellbeing (depressiveness)
Psychological wellbeing (health and vitality)
Psychological wellbeing index (total score)
up to 42,208 European ancestry individuals, up to 14,330 African ancestry individuals
2,633 African ancestry cases, 1,714 African ancestry controls
Affymetrix, Illumina [12148595] (imputed)
Anti-adalimumab antibody production in response to treatment in Crohn's disease
9 European ancestry cases, 53 European ancestry controls
3 European ancestry cases, 85 European ancestry controls
249 Tiwi Islander (founder/genetic isolate) individuals
497 Tiwi Islander (founder/genetic isolate) individuals
Anxiety and stress-related disorders
12,655 European ancestry cases, 19,225 European ancestry controls
Stress-related disorders
9,831 European ancestry cases, 19,225 European ancestry controls
4,584 European ancestry cases, 19,225 European ancestry controls
Anxiety and stress-related disorders (excluding adjustment disorder)
8,517 European ancestry cases, 19,225 European ancestry controls
Anxiety and stress-related disorders (excluding co-morbid schizophrenia)
11,560 European ancestry cases, 19,225 European ancestry controls
Anxiety and stress-related disorders (including obsessive-compulsive disorder)
13,533 European ancestry cases, 19,225 European ancestry controls
Anxiety and stress-related disorders (psychiatric co-morbidity weighting design)
10,311 European ancestry cases, 19,225 European ancestry controls
Anxiety and stress-related disorders (psychiatric co-morbidity covariate model)
12,096 European ancestry cases, 42,215 European ancestry controls
Anxiety and stress-related disorders (propensity-score-matching design)
11,599 European ancestry cases, 11,599 European ancestry controls
Antidepressant treatment resistance (> 2 drugs prescribed)
250 European ancestry cases, 3,202 European ancestry controls, 109 cases, 668 controls
Antidepressant treatment resistance (number of drugs prescribed)
3,452 European ancestry individuals
529 Chilean Latino cases, 566 Chilean Latino controls
626 Chilean Latino cases, 1,017 Chilean Latino controls, 1,909 European ancestry cases, 4,183 European ancestry controls
Diffusing capacity of carbon monoxide
2,584 European ancestry individuals with chronic obstructive pulmonary disease, 3,002 European ancestry healthy individuals, 343 African American individuals with chronic obstructive pulmonary disease, 1,006 African American healthy individuals
926 European ancestry individuals
Cortical amyloid beta load
936 European ancestry individuals
Alzheimer's disease progression score
944 European ancestry individuals
Response to long-term oxygen therapy in chronic obstructive pulmonary disease
290 European ancestry individuals
182 Korean ancestry cases, 240 Korean ancestry controls
Subcutaneous adipose tissue
2,545 European ancestry individuals
Visceral adipose tissue
Visceral adipose tissue/subcutaneous adipose tissue ratio
visceral adipose tissue/total adipose tissue ratio
Asthma control x inhaled corticosteroid treatment interaction (2df)
244 African American individuals
up to 1,366 African American individuals, up to 1,461 Latino ancestry individuals, up to 98 European ancestry individuals
Asthma control x inhaled corticosteroid treatment interaction (1df)
Asthma control
46,008 Danish ancestry cases, 19,526 Danish ancestry controls
4,481 cases, 2,682 controls
9,636 Hispanic/Latino individuals
4,777 Hispanic/Latino individuals
2,700 Lebanese ancestry individuals
396 Mexican ancestry individuals
3,693 Mexican ancestry individuals
Liver iron content
8,289 European ancestry individuals
1,513 European ancestry individuals
757,601 European ancestry individuals
249,262 European ancestry individuals
Asthma exacerbations in inhaled corticosteroid treatment
854 Hispanic/Latino cases, 493 African American cases
1,697 European ancestry cases
Cannabis-related aggression
3,269 African American individuals, 2,546 European ancestry individuals
89 African American individuals
1,328 Korean ancestry cases, 5,870 Korean ancestry controls
309 Korean ancestry cases, 2,529 Korean ancestry controls
Self-reported childhood asthma in adult smokers
385 European ancestry cases, 4979 European ancestry controls, 325 African American cases, 2342 African American controls
Chromosomal aberration frequency (total)
1,770 European ancestry individuals
Chromosomal aberration frequency (chromatid type)
Chromosomal aberration frequency (chromosome type)
Body mass index and waist-hip ratio (pleiotropy)
139 Han Chinese ancestry dizygotic twin pairs
Glycemic traits (pleiotropy)
46,186 European ancestry individuals
10,861 British ancestry cases, 397,594 British ancestry controls
432 European American cases, 367 European American controls
Severity of nausea and vomiting of pregnancy
14,988 European ancestry individuals with no NVP, 14,292 European ancestry individuals with slight NVP, 17,786 European individuals with moderate NVP, 5,445 European ancestry individuals with severe NVP, 1,220 European ancestry individuals with very severe NVP
Hyperemesis gravidarum
1,306 European ancestry cases, 15,756 European ancestry controls without nausea and vomiting of pregnancy (NVP)
899 European ancestry cases, 749 European ancestry controls with and without nausea and vomiting of pregnancy (NVP)
Low susceptibility to hepatitis C infection
27 Spanish ancestry uninfected high-risk individuals, 804 Spanish ancestry infected individuals
BMI at birth
9,286 Norwegian ancestry individuals
5,235 Norwegian ancestry individuals
BMI at 6 weeks old
6,450 Norwegian ancestry individuals
3,444 Norwegian ancestry individuals
BMI at 3 months old
7,970 Norwegian ancestry individuals
4,454 Norwegian ancestry individuals
BMI at 6 months old
8,017 Norwegian ancestry individuals
4,516 Norwegian ancestry individuals
BMI at 8 months old
7,197 Norwegian ancestry individuals
3,966 Norwegian ancestry individuals
BMI at 1 year old
6,970 Norwegian ancestry individuals
3,839 Norwegian ancestry individuals
BMI at 1.5 years old
6,800 Norwegian ancestry individuals
3,780 Norwegian ancestry individuals
BMI at 2 years old
4,631 Norwegian ancestry individuals
2,501 Norwegian ancestry individuals
BMI at 3 years old
5,069 Norwegian ancestry individuals
2,833 Norwegian ancestry individuals
BMI at 5 years old
4,245 Norwegian ancestry individuals
2,209 Norwegian ancestry individuals
BMI at 7 years old
4,629 Norwegian ancestry individuals
2,638 Norwegian ancestry individuals
BMI at 8 years old
3,862 Norwegian ancestry individuals
2,087 Norwegian ancestry individuals
Adult hearing difficulty
87,056 British ancestry cases, 163,333 British ancestry controls
30,765 European ancestry individuals
Adult hearing aid use
13,178 British ancestry cases, 240,740 British ancestry controls
35,004 European ancestry individuals
139 Chinese ancestry dizygotic twin pairs
Anxiety disorder or brain volume (pleiotropy)
7,016 European ancestry anxiety disorder cases, 14,745 European ancestry controls, 13,171 European ancestry individuals
Post-traumatic stress disorder or brain volume (pleiotropy)
2,424 European ancestry post-traumatic stress disorder cases, 7,113 European ancestry controls, 13,171 European ancestry individuals
Cholesterol efflux capacity
3,487 French-Canadian ancestry cases, 1,806 French-Canadian ancestry controls
Cholesterol efflux capacity (cAMP stimulated assay)
Cholesterol efflux capacity (ABCA-1 dependent assay)
Cholesterol efflux capacity (BHK stimulated assay)
115,486 European ancestry individuals
121,745 Japanese ancestry individuals
at least 101,293 European ancestry individuals
121,745 Japanese ancestry individuals, at least 88,461 European ancestry individuals
Sural nerve amplitude potential
6,879 Icelandic ancestry individuals
Sural nerve conduction velocity
6,979 Icelandic ancestry individuals
Bisphosphonate-associated atypical femoral fracture
50 European ancestry cases, 1 Chilean ancestry case, 4,891 European ancestry controls
Atypical femoral fracture in phosphonate treatment
50 European ancestry cases, 1 Chilean ancestry case, 324 European ancestry controls
up to 449,889 European ancestry individuals, up to 29,398 South Asian ancestry individuals, up to 27,610 African American individuals, up to 8,839 East Asian individuals, up to 10,772 Hispanic ancestry individuals
up to 196,766 European ancestry individuals
Genome-wide genotyping array, Targeted genotyping array [Exome array]
up to 449,889 European ancestry individuals
up to 192,226 European ancestry individuals
up to 27,610 African American individuals
up to 8,839 East Asian ancestry individuals
up to 29,398 South Asian ancestry individuals
up to 10,772 Hispanic individuals
Cognitive ability in schizophrenia
3,034 European ancestry individuals
Cocaine dependence
2,085 European ancestry cases, 4,293 European ancestry controls
449 European ancestry individuals
377 Han Chinese ancestry individuals
678 European ancestry cases
1,380 European and unknown ancestry cases
Heart rate in heart failure with reduced ejection fraction
523 European ancestry individuals, 520 African American individuals
240 Han Chinese ancestry cases, 1,031 Han Chinese ancestry controls
252 Han Chinese ancestry cases, 1,852 Han Chinese ancestry controls
4,943 European ancestry cases, 8,483 European ancestry controls
Acute lymphoblastic leukemia (B-cell precursor)
940 Hispanic children cases, 681 Hispanic controls
144 Hispanic cases, 441 Hispanic controls, 2,317 European ancestry cases, 2,050 European ancestry controls, 227 African American cases, 1,380 African American controls
386 Han Chinese ancestry cases, 500 Han Chinese ancestry controls
574 Han Chinese ancestry cases, 569 Han Chinese ancestry controls
Sub-foveal choroidal thickness
3,418 Japanese ancestry individuals
2,692 Japanese ancestry individuals
Cognitive empathy
45,465 European ancestry females, 44,088 European ancestry males
Alzheimer's disease with memory domain impairment
Up to 1,107 European ancestry cases, 3,447 European ancestry controls
Alzheimer's disease with language domain impairment
Up to 510 European ancestry cases, 3,447 European ancestry controls
Alzheimer's disease with visuospatial domain impairment
Up to 497 European ancestry cases, 3,447 European ancestry controls
Alzheimer's disease with multiple cognitive domain impairments
Up to 248 European ancestry cases, 3,447 European ancestry controls
Alzheimer's disease with no specific cognitive domain impairment
Up to 1,584 European ancestry cases, 3,447 European ancestry controls
2,431 European ancestry cases, 3,447 European ancestry controls
Velopharyngeal dysfunction
54 Hispanic or Latin American and unknown ancestry cases, 922 Hispanic or Latin American and unknown ancestry controls
up to 961 individuals
Cerebral amyloid deposition (PET imaging)
983 European ancestry individuals
Neuropathic pain in head and neck cancer
130 European ancestry cases, 913 European ancestry controls
Placental abruption
959 cases, 1553 controls
Non-steroidal anti-inflammatory drug-induced enteropathy
16 Japanese ancestry severe injury cases, 123 Japanese ancestry mild and no injury treated controls
Benign prostatic hyperplasia
2,258 European ancestry cases, 398 African and unknown ancestry cases, 6,599 European ancestry controls, 1,164 African and unknown ancestry controls
Affymetrix, Illumina [10973920] (imputed)
up to 92,771 European ancestry males, up to 113,387 European ancestry females
Affymetrix, Illumina, Perlegen [2437193] (imputed)
148,164 European ancestry individuals
Affymetrix, Illumina, Perlegen [10019203] (imputed)
Post-traumatic stress disorder symptoms in trauma-exposed soldiers
462 Danish ancestry cases, 2,019 Danish ancestry controls
Glioma (pediatric/youth onset)
854 European ancestry cases, 3,689 European ancestry controls
KANNO antigen negativity
4 Japanese ancestry cases, 415 Japanese ancestry controls
Corticosteroid-induced adrenal suppression (peak cortisol < 500 nmol/L)
up to 175 European ancestry child cases with asthma, at least 232 European ancestry child controls with asthma, general adult population controls
32 child cases with asthma, 49 child controls with asthma, 17 adult cases with COPD, 61 adult controls with COPD
Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma
407 European ancestry child cases
Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma
Corticosteroid-induced adrenal suppression (peak cortisol < 350 nmol/L)
up to 35 European ancestry child cases with asthma, at least 372 European ancestry child controls with asthma, general adult population controls
6 child cases with asthma, 75 child controls with asthma
206,856 European ancestry individuals, 143,658 East Asian ancestry individuals
69,591 European ancestry individuals
20,700 European ancestry individuals
2,044 European ancestry cases, 65,575 European ancestry controls
2,714 Hispanic or Latin American cases, 5,239 Hispanic or Latin American controls
Affymetrix, Illumina [10330976] (imputed)
21,564 British ancestry cases, 318,237 British ancestry controls
9,433 British ancestry cases, 318,237 British ancestry controls
Asthma (age of onset)
37,846 British ancestry individuals
9,876 British ancestry cases, 318,237 British ancestry controls
Carotid intima media thickness
Up to 71,128 European ancestry individuals
Affymetrix, Illumina [9574088] (imputed)
Carotid plaque
Up to 21,540 European ancestry cases, up to 26,894 European ancestry controls
Affymetrix, Illumina [8578107] (imputed)
group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP
6,692 European ancestry individuals
Percent glycated albumin
7,647 European ancestry individuals, 2,104 Black individuals
1,304 European ancestry individuals, 608 Black individuals
Total glycated albumin levels
Fructosamine levels
Alcohol dependence
2,411 European ancestry cases, 880 African American cases, 2,438 European ancestry controls, 951 African American controls
2,280 European ancestry cases, 1,911 African American cases, 1,964 European ancestry controls, 815 African American controls
Alcohol dependence symptom count
7,418 European ancestry individuals, 3,175 African American individuals
5,053 European ancestry individuals, 2,940 African American individuals
Alcohol dependence (tolerance)
3,348 European ancestry cases, 1,110 African American cases, 3,958 European ancestry controls, 2,024 African American controls
3,051 European ancestry cases, 1,545 African American cases, 2,001 European ancestry controls, 1,395 African American controls
Alcohol dependence (withdrawal)
1,259 European ancestry cases, 514 African American cases, 6,046 European ancestry controls, 2,616 African American controls
735 European ancestry cases, 894 African American cases, 4,318 European ancestry controls, 2,046 African American controls
Alcohol dependence (drinking more than intended)
3,826 European ancestry cases, 1,317 African American cases, 3,480 European ancestry controls, 1,817 African American controls
3,129 European ancestry cases, 2,032 African American cases, 1,921 European ancestry controls, 906 African American controls
Alcohol dependence (desire to cut drinking)
2,896 European ancestry cases, 1,436 African American cases, 4,413 European ancestry controls, 1,701 African American controls
2,021 European ancestry cases, 1,836 African American cases, 3,032 European ancestry controls, 1,104 African American controls
Alcohol dependence (giving up activities)
1,437 European ancestry cases, 578 African American cases, 5,871 European ancestry controls, 2,558 African American controls
520 European ancestry cases, 1,416 African American cases, 4,533 European ancestry controls, 1,524 African American controls
Alcohol dependence (time spent drinking)
1,533 European ancestry cases, 546 African American cases, 5,776 European ancestry controls, 2,590 African American controls
1,022 European ancestry cases, 1,255 African American cases, 4,031 European ancestry controls, 1,685 African American controls
Alcohol dependence (drinking despite problems)
2,163 European ancestry cases, 784 African American cases, 5,144 European ancestry controls, 2,351 African American controls
1,921 European ancestry cases, 1,299 African American cases, 3,131 European ancestry controls, 1,640 African American controls
Primary central nervous system lymphoma
475 European ancestry cases, 1,134 European ancestry controls
1,335 European ancestry cases, 9,768 European ancestry controls
135,458 European ancestry cases, 344,901 European ancestry controls
DNA methylation variation (age effect)
Up to 954 individuals
Bicuspid aortic valve
452 European ancestry cases, 1,834 European ancestry controls
1,679 cases, 894 controls
Up to 53 African American individuals, 100 Asian ancestry individuals, 4,175 European ancestry individuals, 138 Hispanic or Latin American individuals, 30 Native American individuals, 11 Pacific Islander ancestry individuals, 168 unknown ancestry individuals
53 African American individuals, 100 Asian ancestry individuals, 4,175 European ancestry individuals, 138 Hispanic or Latin American individuals, 30 Native American individuals, 11 Pacific Islander ancestry individuals, 168 unknown ancestry individuals
31,197 European ancestry cases, 61,770 European ancestry controls
Affymetrix, Illumina [> 10000000] (imputed)
35,380 European ancestry non-diabetic individuals, 12,738 African American non-diabetic individuals
50,900 European ancestry non-diabetic individuals, 9,664 African American non-diabetic individuals
Obesity (extreme) (SNP x SNP interaction)
493 European ancestry female cases, 537 European ancestry female controls
Cellular nuclear factor (erythroid-derived 2)-like 2 levels
74 East Asian ancestry lymphoblastoid cell lines
Sero-negative rheumatoid arthritis
3,323 European ancestry cases, 15,785 European ancestry controls
Liver injury in anti-tuberculosis drug treatment
79 Thai ancestry cases, 239 Thai ancestry controls
10,846 European ancestry cases, 11,672 European ancestry controls
Affymetrix, Illumina [8004650] (imputed)
19,112 European ancestry male individuals
Affymetrix, Illumina [7487927] (imputed)
11,006 European ancestry female individuals
30,118 European ancestry individuals
Strabismus
1,345 British ancestry cases, 65,349 British ancestry controls
116 cases, 5,084 controls
Candidemia
161 European ancestry cases, 152 European ancestry controls
15,124 Hispanic or Latin American individuals
Affymetrix, Illumina [~ 21000000] (imputed)
2,120 European ancestry cases, 1,944 European ancestry controls
8,168 European ancestry cases, 65,134 European ancestry controls, 1,278 African ancestry cases, 1,914 African ancestry controls
12,111 European ancestry cases, 138,477 European ancestry controls, 247 African ancestry cases, 713 African ancestry controls
Health literacy
1,771 English ancestry cases, 4,012 English ancestry controls
943 Chinese ancestry cases, 3,908 Chinese ancestry controls
2,142 Chinese ancestry cases, 4,697 Chinese ancestry controls
1,760 Korean ancestry non-responder adults, 5,107 Korean ancestry responder adults
2,327 Korean ancestry adults, 49 Korean ancestry non-responder infants, 234 Korean ancestry responder infants
40,675 European ancestry cases, 64,643 European ancestry controls
1,651 European ancestry cases, 4,111 cases, 142,717 European ancestry controls, 11,507 controls
27,174 European ancestry cases, 736,838 European ancestry controls
Response to belimumab (SLE response index) in systemic lupus erythematosus
443 European, Asian, American Indian or Alaskan Native, African American or unknown ancestry responders, 373 European, Asian, American Indian or Alaskan Native, African American or unknown ancestry non-responders
101 Northeast Asian ancestry responders, 103 Northeast Asian ancestry non-responders
283 European ancestry cases, 4,472 European ancestry controls
1,178 cases, 3,759 controls
720 European ancestry cases, 6,490 European ancestry controls
108 European ancestry cases, 75,545 European ancestry controls
Arterial stiffness
131,686 British ancestry individuals
Arterial stiffness index
127,121 European ancestry individuals
Extranodal natural killer T-cell lymphoma (nasal type)
189 East Asian ancestry cases, 957 East Asian ancestry controls
514 East Asian ancestry cases, 5,822 East Asian ancestry controls
Platelet aggregation
3,664 European ancestry individuals, 549 Old Order Amish (founder/genetic isolate) individuals
1,184 European ancestry individuals, 613 African American individuals
Autoimmune traits (pleiotropy)
11,489 European ancestry cases with celiac disease, 15,523 European ancestry cases with rheumatoid arthritis, 3,477 European ancestry cases with systemic sclerosis, 6,670 European ancestry cases with type 1 diabetes, 22,308 European ancestry controls
11,489 European ancestry cases, 22,308 European ancestry controls
6,670 European ancestry cases, 22,308 European ancestry controls
15,523 European ancestry cases, 22,308 European ancestry controls
3,477 European ancestry cases, 22,308 European ancestry controls
Age-related macular degeneration (MTAG)
37,342 European ancestry cases, 92,890 European ancestry controls
7,126 European ancestry cases, 174,286 European ancestry controls
Breast cancer and/or colorectal cancer
589 European ancestry colorectal cancer with a family history of breast cancer cases, 378 European ancestry breast cancer cases with a family history of colorectal cancer cases, 18 European ancestry breast and colorectal cancer cases, 1,769 European ancestry controls
Alcohol or illicit drug dependence
2,927 European ancestry cases, 4,364 European ancestry controls, 1,315 African American cases, 1,817 African American controls
630 European ancestry cases, 1,020 European ancestry controls, 1,912 African American cases, 900 African American controls
Type 2 diabetes and end-stage kidney disease
3,432 African-American cases, 6,977 African-American controls
Type 2 diabetes and end-stage kidney disease in APOL1 risk genotype negative individuals
2,768 African-American cases, 6,059 African-American controls
Emotional lability in attention deficit hyperactivity disorder
563 European ancestry individuals
Number of twin births
8,962 European ancestry cases, 409,591 European ancestry controls
Geographic atrophy lesion growth rate in age-related macular degeneration
935 European ancestry individuals
Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)
379 European ancestry cases
2,873 Korean ancestry cases, 5,966 Korean ancestry controls
Pre-treatment viral load in HIV-1 infection
1,398 European ancestry individuals, 572 Black individuals, 418 Hispanic individuals, 13 Asian ancestry individuals, 39 individuals
Thyroglobulin plasma levels
1,094 Croatian ancestry individuals
Right-sided colonic diverticulosis
893 Korean ancestry cases, 1,075 Korean ancestry controls
346 Korean ancestry cases, 305 Korean ancestry controls
607 East Asian ancestry individuals
158 East Asian ancestry individuals
19,326 European ancestry individuals from up to 4,933 families
28,676 European ancestry individuals
3,771 Chinese ancestry cases, 5,426 Chinese ancestry controls
7,035 Chinese ancestry cases, 8,323 Chinese ancestry controls
Affymetrix, Illumina [6192596] (imputed)
5,994 non-diabetic individuals, 651 diabetic individuals
984 cases, 2,012 controls
5,994 non-diabetic individuals
7,805 Japanese ancestry individuals
T-Cell Immunoglobulin and Mucin domain 1 levels
4,505 European ancestry individuals
4,433 European ancestry individuals
anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)
19,009 European ancestry ADHD cases, 3,495 European ancestry anorexia cases, 18,381 European ancestry autism cases, 20,352 European ancestry bipolar disorder cases, 130,664 European ancestry major depression cases, 2,688 European ancestry OCD cases, 33,640 European ancestry schizophrenia cases, 4,645 European ancestry Tourette's cases, 494,162 European ancestry controls
987 Japanese ancestry cases, 3,206 Japanese ancestry controls
249 Korean ancestry cases, 181 South Asian ancestry cases, 207 African ancestry cases, 307 European ancestry cases, 27 Hispanic cases, 85 Maghrebian ancestry cases, 3805 Korean ancestry controls, 8,255 South Asian ancestry controls, 5,657 African ancestry controls, 35,913 European ancestry controls, 5,789 Hispanic controls, 261 Moroccan ancestry controls
1,902 Korean ancestry males
2,912 Korean ancestry individuals
288,649 European ancestry individuals, 125,725 East Asian ancestry individuals, 33,671 African American individuals, 9,037 South Asian ancestry individuals, 608 Hispanic individuals
Affymetrix, Illumina [8249849] (imputed)
288,649 European ancestry individuals
Affymetrix, Illumina [8217339] (imputed)
174,111 European, East Asian, African American, South Asian and Hispanic ancestry men, 172,102 European, East Asian, African American, South Asian and Hispanic ancestry women
13,179 European, African American and unknown ancestry cases, 750,634 European, African American and unknown ancestry controls
105,534 Japanese ancestry individuals
Diabetic retinopathy in type 2 diabetes
206 East Asian ancestry cases, 206 East Asian ancestry controls
Breast cancer in BRCA2 mutation carriers
4,330 European ancestry affected women, 3,881 European ancestry unaffected women
Coronary artery calcification
2,158 Europen ancestry males, 2,171 European ancestry females
47,637 European ancestry cases, 1,422,823 European ancestry controls
Left-handedness
1,766,671 European ancestry individuals
Carotid plaque maximum area
727 European ancestry men, 550 European ancestry women
Sum of carotid plaque area
Mean area of carotid plaque
Maximum stenosis
Mean degree of stenosis
Sum of stenosis
Cognitive performance in schizophrenia or bipolar disorder
1,095 European ancestry individuals with schizophrenia, 2,864 European ancestry individuals with bipolar disorder, 1,594 African Americans with schizophrenia, 1,007 African Americans with bipolar disorder
666 Han Chinese ancestry cases, 3,988 Han Chinese ancestry controls
up to 884 Han Chinese ancestry cases, up to 5,329 Han Chinese ancestry controls
700 Han Chinese ancestry cases, 7,752 Han Chinese ancestry controls
717 East Asian ancestry cases, 12,650 East Asian ancestry controls
Visceral fat, circulating phospholipid PC(16:0/2:0) and white matter microstructure (shared variance)
872 French-Canadian (founder/genetic isolate) ancestry adolescents from up to 486 families
Soluble gp130 levels
3,439 European ancestry individuals
Targeted genotyping array [Cardio-MetaboChip, Immunochip]
Anxiety disorder (factor score)
28,950 European ancestry individuals, 2,482 African American individuals, 3,264 Latino individuals
Breast cancer somatic mutation signature APOBEC C>T or C>G
974 European, African American and Asian ancestry individuals
170 Nigerian ancestry individuals
Breast cancer somatic mutation signature APOBEC C>T
Breast cancer somatic mutation signature APOBEC C>G
Breast cancer somatic mutation signature Aging
Breast cancer somatic mutation signature Homologous Recombination Deficiency
Central serous retinopathy
610 Japanese ancestry cases, 2,850 Japanese ancestry controls
415 Japanese ancestry cases, 6,602 Japanese ancestry controls, 521 European ancestry cases, 3,577 European ancestry controls
4,626 Greenlandic individuals
1,529 Greenlandic individuals, 1,058 Yup’ik Alaska Native ancestry individuals
Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease)
53,137 European ancestry cases, 79,230 European ancestry controls
Medication use (drugs used in diabetes)
15,272 European ancestry cases, 29,0641 European ancestry controls
Medication use (antithrombotic agents)
67,653 European ancestry cases, 85,986 European ancestry controls
Medication use (vasodilators used in cardiac diseases)
5,546 European ancestry cases, 237,113 European ancestry controls
Medication use (antihypertensives)
6,431 European ancestry cases, 145,949 European ancestry controls
Medication use (diuretics)
34,453 European ancestry cases, 194,633 European ancestry controls
Medication use (beta blocking agents)
31,700 European ancestry cases, 192,324 European ancestry controls
Medication use (calcium channel blockers)
31,904 European ancestry cases, 172,474 European ancestry controls
Medication use (agents acting on the renin-angiotensin system)
62,752 European ancestry cases, 174,778 European ancestry controls
Medication use (HMG CoA reductase inhibitors)
73,475 European ancestry cases, 216,910 European ancestry controls
Medication use (thyroid preparations)
24,832 European ancestry cases, 280,750 European ancestry controls
Medication use (immunosuppressants)
3,954 European ancestry cases, 268,648 European ancestry controls
Medication use (anti-inflammatory and antirheumatic products, non-steroids)
74,150 European ancestry cases, 90,370 European ancestry controls
Medication use (drugs affecting bone structure and mineralization)
7,870 European ancestry cases, 207,798 European ancestry controls
Medication use (opioids)
22,982 European ancestry cases, 55,826 European ancestry controls
Medication use (salicylic acid and derivatives)
61,583 European ancestry cases, 50,427 European ancestry controls
Medication use (anilides)
83,218 European ancestry cases, 96,592 European ancestry controls
Medication use (antimigraine preparations)
5,521 European ancestry cases, 114,323 European ancestry controls
Medication use (antidepressants)
33,757 European ancestry cases, 270,405 European ancestry controls
Medication use (adrenergics, inhalants)
28,880 European ancestry cases, 147,565 European ancestry controls
Medication use (glucocorticoids)
17,352 European ancestry cases, 188,348 European ancestry controls
Medication use (antihistamines for systemic use)
13,984 European ancestry cases, 137,652 European ancestry controls
Medication use (antiglaucoma preparations and miotics)
5,215 European ancestry cases, 95,653 European ancestry controls
Sensitivity to environmental stress and adversity
351,827 European ancestry individuals
3,563 European ancestry children and adolescents
Childhood onset ulcerative colitis
466 European ancestry cases, 2,099 European ancestry controls
Diffuse cutaneous systemic sclerosis
574 European ancestry cases, 3,466 European ancestry controls
1,217 European ancestry cases, 5,935 European ancestry controls
671 European ancestry ACA-positive cases, 347 European ancestry ATA-positive cases, 815 European ancestry cases, 3,466 European ancestry controls
1,387 European ancestry ACA-positive cases, 896 European ancestry ATA-positive cases, 1,734 European ancestry cases, 5,935 European ancestry controls
Limited cutaneous systemic scleroderma
1,127 European ancestry cases, 3,466 European ancestry controls
2,507 European ancestry cases, 5,935 European ancestry controls
Temporomandibular joint disorder
769 Hispanic cases, 9,384 Hispanic controls
768 European ancestry cases, 4,845 European ancestry controls, 144 Hispanic/Latin American cases, 492 Hispanic/Latin American controls, 999 cases, 2,031 controls
Fuchs's corneal dystrophy
1,404 European ancestry cases, 2,564 European ancestry controls
671 European ancestry cases, 778 European ancestry controls
200 Chinese ancestry cases, 228 Chinese ancestry controls
200 Chinese ancestry cases, 1,400 Chinese ancestry controls
Insulin levels in response to oral glucose tolerance test (fasting)
3,344 Swedish ancestry individuals
4,905 Finnish ancestry individuals
GIP levels in response to oral glucose tolerance test (fasting)
GLP-1 levels in response to oral glucose tolerance test (fasting)
Insulin levels in response to oral glucose tolerance test (30 minutes)
Insulin levels in response to oral glucose tolerance test (120 minutes)
GLP-1 levels in response to oral glucose tolerance test (120 minutes)
GIP levels in response to oral glucose tolerance test (120 minutes)
ACPA-negative rheumatoid arthritis (smoking interaction)
340 European ancestry never-smoker cases, 493 European ancestry ever-smoker cases, 746 European ancestry never-smoker controls, 994 European ancestry ever-smoker controls
ACPA-positive rheumatoid arthritis (smoking interaction)
187 European ancestry never-smoker cases, 421 European ancestry ever-smoker cases, 461 European ancestry never-smoker controls, 447 European ancestry ever-smoker controls
390 European ancestry cases, 364 European ancestry controls
38,430 European ancestry cases, 2,572 East Asian ancestry cases, 41,926 European ancestry controls, 2,059 East Asian ancestry controls
11,645 European ancestry cases, 12,015 European ancestry controls
23 Japanese ancestry cases, 2,002 Japanese ancestry controls
21 Japanese ancestry cases, 991 Japanese ancestry controls
13,100 European ancestry cases, 13,220 European ancestry controls, 1,472 African American cases, 3,511 African American controls, 951 Japanese ancestry cases, 894 Japanese ancestry controls, 51 Israeli-Arab ancestry cases, 64 Israeli-Arab ancestry controls
5,813 European ancestry cases, 20,474 European ancestry controls
Alzheimer's disease (APOE e4 interaction)
8,271 European ancestry APOE e4+ cases, 3,480 European ancestry APOE e4+ controls, 4,829 European ancestry APOE e4- cases, 9,740 European ancestry APOE e4- controls, 865 African American APOE e4+ cases, 1,241 African American APOE e4+ control, 607 African American APOE 4e- cases, 2,270 African American APOE 4e- controls, 535 Japanese ancestry APOE 4e+ cases, 151 Japanese ancestry APOE 4+ controls, 416 Japanese ancestry APOE 4- cases, 743 Japanese ancestry APOE 4- controls, 51 Arab-Israeli ancestry APOE e4- cases, 64 Arab-Israeli ancestry e4- controls
3,062 European ancestry APOE e4+ cases, 8,977 European ancestry APOE e4+ controls, 2,751 European ancestry APOE e4- cases, 11,497 European ancestry APOE e4- controls
Alzheimer's disease in APOE e4+ carriers
8,271 European ancestry cases, 3,480 European ancestry controls, 865 African American cases, 1,241 African American control, 535 Japanese ancestry cases, 151 Japanese ancestry controls
3,062 European ancestry cases, 8,977 European ancestry controls
Alzheimer's disease in APOE e4- carriers
4,829 European ancestry cases, 9,740 European ancestry controls, 607 African American cases, 2,270 African American controls, 416 Japanese ancestry cases, 743 Japanese ancestry controls, 51 Israeli-Arab ancestry cases, 64 Israeli-Arab ancestry controls
2,751 European ancestry cases, 11,497 European ancestry controls
Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy)
3,135 European ancestry Alzheimer's disease cases, 463 European ancestry controls
Neuritic plaques or neurofibrillary tangles (pleiotropy)
Neuritic plaques or cerebral amyloid angiopathy (pleiotropy)
Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy)
3,135 European ancestry Alzheimer's diseases cases, 463 European ancestry controls
NHDL cholesterol to HDL cholesterol ratio
5,292 Korean ancestry individuals
2,567 Korean ancestry individuals
LDL cholesterol to HDL cholesterol ratio
Triglyceride to HDL cholesterol ratio
Basal cell carcinoma
17,187 European ancestry cases, 287,054 European ancestry controls
Affymetrix, Illumina [8262488] (imputed)
Immunoglobulin light chain (AL) amyloidosis
1,229 cases, 7,526 controls
Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications
117 Japanese ancestry cases, 688 Japanese ancestry controls
52 East Asian ancestry cases, 302 East Asian ancestry controls
Western dietary pattern
141 individuals
Prudent dietary pattern
Orofacial clefts (cleft lip vs. cleft lip and palate)
56 African ancestry cleft lip cases, 121 Asian ancestry cleft lip cases, 128 European ancestry cleft lip cases, 145 Latin/South American cleft lip cases, 91 African ancestry cleft lip with cleft palate cases, 246 Asian ancestry cleft lip with cleft palate cases, 448 European ancestry cleft lip with cleft palate cases, 905 Latin/South American cleft lip with cleft palate cases, 2 cleft lip with cleft palate cases
176 Brazilian ancestry cleft lip cases, 168 Mongolian ancestry cleft lip cases, 16 Filipino ancestry cleft lip cases, 213 European ancestry cleft lip cases, 224 Asian ancestry cleft lip cases, 287 Brazilian ancestry cleft lip with cleft palate cases, 374 Mongolian ancestry cleft lip with cleft palate cases, 64 Filipino ancestry cleft lip with cleft palate cases, 385 European ancestry cleft lip with cleft palate cases, 703 Asian ancestry cleft lip with cleft palate cases.
14,756 Hispanic individuals
4,296 European ancestry individuals, 3,763 African American individuals, 6,805 East Asian ancestry individuals
Affymetrix, Illumina [18828993] (imputed)
Small vessel stroke
342 Chinese ancestry cases, 1,731 Chinese ancestry control
188 Chinese ancestry cases, 1,265 Chinese ancestry control
Heart rate response to beta blockers (atenolol monotherapy)
228 European American hypertensive individuals, 146 African American hypertensive individuals
Heart rate response to beta blockers (atenolol add-on therapy)
198 European American hypertensive individuals, 127 African American hypertensive individuals
Heart rate response to beta blockers
426 European American hypertensive individuals, 273 African American hypertensive individuals
200 European American hypertensive individuals, 168 African American hypertensive individuals
up to 4,692 European ancestry individuals, up to 1,539 Han Chinese ancestry individuals, up to 849 African American individuals, up to 446 Hispanic individuals, 2,882 European ancestry whole-genome sequenced individuals, 3,549 European ancestry whole-exome sequenced individuals, 26,534 European ancestry non-array genotype imputed individuals
Affymetrix, Illumina [7998108] (imputed)
Idiopathic dilated cardiomyopathy
662 African American cases, 1,138 African American controls
263 South African Black cases and 374 South African Black controls
3,058 European ancestry individuals
2,014 African American individuals
13,903 European ancestry cases, 19,279 European ancestry controls.
Affymetrix, Illumina [8837380] (imputed)
Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease (adjusted for baseline)
10,874 European, Asian, African, Arabic, Native American, Pacific Islander and other ancestry
Affymetrix, Illumina [13572687] (imputed)
Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease
Major coronary event in placebo-treated cardiovascular disease (time to event)
1,440 European, African American, Asian and other ancestry cases
Affymetrix, Illumina [9334585] (imputed)
Diarrhoea in darapladib-treated cardiovascular disease (time to event)
481 European ancestry cases
Myocardial infarction in darapladib-treated cardiovascular disease (time to event)
740 European, African American, Asian and other ancestry cases
Myocardial infarction in placebo-treated cardiovascular disease (time to event)
833 European, African American, Asian and other ancestry cases
Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction)
1,318 European, African American, Asian and other ancestry darapladib-treated cases, 1,440 European, African American, Asian and other ancestry placebo-treated cases
Odor events in darapladib-treated cardiovascular disease (time to event)
1,867 European, African American, Asian and other ancestry cases
Major coronary event in darapladib-treated cardiovascular disease (time to event)
1,318 European, African American, Asian and other ancestry cases
Lipoprotein phospholipase A2 activity in cardiovascular disease
22,156 European, Asian, African, Arabic, Native American, Pacific Islander and other ancestry
Myocardial infarction in cardiovascular disease (time to event) (darapladib treatment interaction)
740 European, African American, Asian and other ancestry darapladib-treated cases, 833 European, African American, Asian and other ancestry placebo-treated cases
Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event)
212 European ancestry cases
at least 3,569 European, Black, and unknown ancestry cases, at least 19,085 European, Black, and unknown ancestry controls
Alzheimer's disease (age of onset)
12,169 European ancestry individuals, 2,078 Black individuals, 4,053 unknown ancestry individuals
4,508 East Asian ancestry cases, 16,588 East Asian ancestry controls
11,044 East Asian ancestry cases, 18,036 East Asian ancestry controls
Affymetrix, Illumina [~ 4000000] (imputed)
779 Han Chinese ancestry cases, 13,227 Han Chinese ancestry controls
5,125 Asian ancestry cases, 17,604 Asian ancestry controls
212 European ancestry trios
Type 2 diabetes (age of onset)
2,307 Celtic ancestry individuals, 1,102 Slavic ancestry individuals
Primary sclerosing cholangitis
2,871 European ancestry cases, 12,019 European ancestry controls
1,925 European ancestry cases, 7,936 European ancestry controls
Affymetrix, Illumina [7891602] (imputed)
862 Han Chinese ancestry cases, 880 Han Chinese ancestry controls
5,514 Han Chinese ancestry cases, 5,464 Han Chinese ancestry controls
656 Han Chinese ancestry cases, 933 Han Chinese ancestry controls
1,365 Han Chinese ancestry cases, 2,854 Han Chinese ancestry controls
3,194 European ancestry cases, 7,060 European ancestry controls.
Ovarian disease with few adhesions
1,686 European ancestry cases, 7,060 European ancestry controls.
Deep ovarian and/or rectovaginal disease with dense adhesions
1,364 European ancestry cases, 7,060 European ancestry controls.
Early-onset Parkinson's disease
403 Finnish ancestry cases, 1,650 Finnish ancestry controls
Chronic venous disease
323 German ancestry cases and 4,619 German ancestry controls
1,946 German ancestry cases and 3,146 German ancestry controls
Heart rate increase in response to exercise
5,4137 European ancestry individuals, 1,744 Asian ancestry individuals, 1,445 African ancestry individuals, 468 admixed individuals, 1,024 individuals
Heart rate response to recovery post exercise (30 sec)
5,4137 European ancestry individuals, 1,744 Asian individuals, 1,445 African individuals, 468 admixed individuals, 1,024 individuals
Heart rate response to recovery post exercise (40 sec)
Heart rate response to recovery post exercise (50 sec)
Heart rate response to recovery post exercise (10 sec)
Heart rate response to recovery post exercise (20 sec)
Food allergy (parent-of-origin effect)
482 European ancestry trios, 19 European ancestry father-child pairs, 59 European ancestry mother-child pairs, 28 European ancestry affected children
Peanut allergy (parent-of-origin effect)
247 European ancestry trios, 7 European ancestry father-child pairs, 33 European ancestry mother-child pairs, 14 European ancestry affected child
Milk allergy (parent-of-origin effect)
230 European ancestry trios, 10 European ancestry father-child pairs, 25 European ancestry mother-child pairs, 10 European ancestry affected child
Egg allergy (parent-of-origin effect)
169 European ancestry trios, 5 European ancestry father-child pairs, 19 European ancestry mother-child pairs, 8 European ancestry affected child
Food allergy (maternal genetic effects)
588 European ancestry complete and incomplete trios
Peanut allergy (maternal genetic effects)
301 European ancestry complete and incomplete trios
Milk allergy (maternal genetic effects)
275 European ancestry complete and incomplete trios
Egg allergy (maternal genetic effects)
201 European ancestry complete and incomplete trios
6,692 Japanese ancestry cases, 27,178 Japanese ancestry controls
3,713 Japanese ancestry cases, 7,333 Japanese ancestry controls
Systolic blood pressure x smoking status (current vs non-current) interaction (1df test)
14,607 European ancestry current smokers, 65,935 European ancestry former and never smokers, 5,545 African ancestry current smokers, 21,571 African ancestry former and never smokers, 2,465 Asian ancestry current smokers, 10,973 Asian ancestry former and never smokers, 1,068 Hispanic current smokers, 7,737 Hispanic former and never smokers
48,198 European ancestry current smokers, 251,872 European ancestry former and never smokers, 1,971 African ancestry current smokers, 5,814 African ancestry former and never smokers, 29,485 Asian ancestry current smokers, 119,447 Asian ancestry former and never smokers, 3,737 Hispanic current smokers, 14,199 Hispanic former and never smokers
Affymetrix, Illumina [18800000] (imputed)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)
Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test)
43,016 European ancestry ever smokers, 37,535 European ancestry never smokers, 12,693 African ancestry ever smokers, 13,121 African ancestry never smokers, 4,142 Asian ancestry ever smokers, 9,296 Asian ancestry never smokers, 3,228 Hispanic ever smokers, 5,577 Hispanic never smokers
139,127 European ancestry ever smokers, 145,914 European ancestry never smokers, 3,105 African ancestry ever smokers, 3,075 African ancestry never smokers, 70,335 Asian ancestry ever smokers, 78,597 Asian ancestry never smokers, 6,810 Hispanic ever smokers, 11,133 Hispanic never smokers
Diastolic blood pressure x smoking status (ever vs never) interaction (1df test)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)
Systolic blood pressure x smoking status (ever vs never) interaction (1df test)
Systolic blood pressure (cigarette smoking interaction)
80,552 European ancestry individuals, 27,118 African individuals, 13,438 Asian individuals, 8,805 Hispanic individuals
305,513 European ancestry individuals, 7,786 African individuals, 148,932 Asian individuals, 13,533 Hispanic individuals, 4,414 Brazilian individuals
Diastolic blood pressure (cigarette smoking interaction)
870 European ancestry cases, 5,293 European ancestry controls
1,383 European ancestry cases, 1,728 European ancestry controls
371 European ancestry female cases, 76 European ancestry male cases, 533 European ancestry female controls, 204 European ancestry male controls
715 European, Black, Hispanic and other ancestry trios, 216 European ancestry cases, 336 European ancestry controls, 1,050 Japanese ancestry female cases, 1,474 Japanese ancestry female controls
Urate levels in lean individuals
up to 5,529 European ancestry male individuals, up to 9,753 European ancestry female individuals
Affymetrix, Illumina [at least 188473] (imputed)
Urate levels (BMI interaction)
up to 15,007 European ancestry male individuals, up to 16,943 European ancestry female individuals
Urate levels in overweight individuals
up to 10,058 European ancestry male individuals, up to 7,189 European ancestry female individuals
Urate levels in obese individuals
4,613 European ancestry male individuals, 4,690 European ancestry female individuals, 142 European ancestry individuals
28,610 European ancestry individuals
13,959 European ancestry individuals
Information processing speed
Up to 30,807 European ancestry individuals, up to 1,267 Erasmus Rucphen (founder/genetic isolated) individuals, up to 535 Korculan (founder/genetic isolated) individuals, up to 417 Orcadian (founder/genetic isolated) individuals, up to 311 Vis (founder/genetic isolated) individuals
Up to 8,436 European ancestry individuals, up to 1,444 African American individuals
Affymetrix, Illumina [up to 2357391] (imputed)
Executive function
Up to 10,904 European ancestry individuals, up to 1,263 Erasmus Rucphen (founder/genetic isolated) individuals, up to 495 Korculan (founder/genetic isolated) individuals, up to 418 Orcadian (founder/genetic isolated) individuals, up to 382 Vis (founder/genetic isolated) individuals
Up to 20,720 European ancestry individuals, up to 3,146 African American individuals
HIV-1 susceptibility
628 African American high risk-cases, 1,376 African American high-risk controls, 327 European ancestry high-risk cases, 805 European ancestry high-risk controls
1,395 African American high-risk cases, 457 African American high-risk controls, 513 European ancestry high-risk cases, 168 European ancestry high-risk controls
Number of children (6+ vs. 0 or 1)
1,686 Bangladeshi women
Number of children
Number of pregnancies
Survival in microsatellite instability low/stable colorectal cancer
431 European ancestry cases
334 European ancestry cases
Survival in rectal cancer
171 European ancestry cases
4,572 European ancestry cases, 266,358 European ancestry controls
up to 956 European ancestry cases, up to 4,214 European ancestry controls, 526 cases, 528 controls
48 African American responder cases, 46 African American non-responder cases
Disease-free survival in breast cancer
1,732 Korean ancestry cases
1,494 Korean ancestry cases
Insulin resistance/response
2,764 European ancestry individuals
1,601 Hispanic ancestry individuals, 1,259 European ancestry individuals
Affymetrix, Illumina [12106458] (imputed)
7,507 European ancestry cases, 52,632 European ancestry controls
3,009 European ancestry cases, 2,586 European ancestry controls
Affymetrix, Illumina [6751884] (imputed)
89 Indonesian ancestry cases, 46 Indonesian ancestry controls
2,088 European ancestry individuals
541 European ancestry individuals
Sitting height ratio
3,545 African American individuals, 12,965 European ancestry women, 8,625 European ancestry men
Affymetrix, Illumina [up to 10250422] (imputed)
Testicular germ cell tumor
1,326 European ancestry cases, 6,687 European ancestry controls
710 European ancestry case-parent triads, 289 European ancestry cases, 290 European ancestry controls
398 European ancestry cases , 502 European ancestry controls
1,422 European ancestry cases, 1,908 European ancestry controls
916 pre-term birth neonates, 935 term birth neonates
243 pre-term birth neonates, 149 term birth neonates
Spontaneous preterm birth (preterm delivery)
935 pre-term delivery mothers, 946 term delivery mothers
66 European ancestry pre-term delivery mothers, 110 African American pre-term delivery mothers, 110 Hispanic pre-term delivery mothers, 7 pre-term delivery mothers, 37 European ancestry term delivery mothers, 84 African American term delivery mothers, 74 Hispanic term delivery mothers, 5 term delivery mothers
Sasang constitutional medicine type (So-Eum)
1,905 Korean ancestry So-Eum type individuals, 1,905 Korean ancestry non-So-Eum type individuals
840 Korean ancestry So-Eum type individuals, 840 Korean ancestry non-So-Eum type individuals
Sasang constitutional medicine type (Tae-Eum)
1,905 Korean ancestry Tae-Eum type individuals, 1,905 Korean ancestry non-Tae-Eum type individuals
840 Korean ancestry Tae-Eum type individuals, 840 Korean ancestry non-Tae-Eum type individuals
Sasang constitutional medicine type (So-Yang)
1,905 Korean ancestry So-Yang type individuals, 1,905 Korean ancestry non-So-Yang type individuals
840 Korean ancestry So-Yang type individuals, 840 Korean ancestry non-So-Yang type individuals
Sasang constitutional medicine type (Tae-Yang)
1,905 Korean ancestry Tae-Yang type individuals, 1,905 Korean ancestry non-Tae-Yang type individuals
840 Korean ancestry Tae-Yang type individuals, 840 Korean ancestry non-Tae-Yang type individuals
Cutaneous lupus erythematosus
151 European ancestry cases, 1,288 European ancestry controls
219 European ancestry cases, 262 European ancestry controls
Total bilirubin levels in HIV-1 infection
2,547 individuals
Neutrophil count in HIV-infection
HDL Cholesterol in HIV-infection
Vein graft stenosis in coronary artery bypass grafting
361 European ancestry cases, 160 European ancestry controls
2,317 European ancestry children, 1,283 African American ancestry children
5,261 European ancestry children, 3,817 African American ancestry children
Cytokine-stimulated IL-6 production
60 European ancestry lymphoblastoid cell lines
Cytokine and corticosteroid-stimulated IL-6 production
Psychotic symptoms and prion disease
Up to 170 cases, 5,200 controls
Mood disorder and prion disease
Behavioral disturbance or psychiatric symptoms and prion disease
Psychotic symptoms in prion disease
Up to 170 cases
Mood disorder in prion disease
Behavioral disturbance or psychiatric symptoms in prion disease
Response to serotonin reuptake inhibitors in major depressive disorder
298 European ancestry cases, 567 Asian ancestry cases, 1529 European and other ancestry cases
386 Han Chinese ancestry cases, 558 Han Chinese ancestry controls
755 Han Chinese ancestry cases, 944 Han Chinese ancestry controls
Carotid artery intima media thickness (sex interaction)
931 Hispanic individuals
153 European ancestry individuals, 257 Black individuals
Breast cancer (survival)
23,059 European ancestry estrogen-receptor positive cases, 6,881 European ancestry estrogen-receptor negative cases, 8,014 European ancestry cases
478 European ancestry cases, 880 European ancestry controls
(see Smoller, 2013)
Response to anti-TNF treatment (adalimumab, etanercept or infliximab) in rheumatoid arthritis
269 European ancestry responders, 92 European ancestry non-responders
181 European ancestry responders, 64 European ancestry non-responders
LDL cholesterol subfractions
1,868 European ancestry individuals
6,745 European ancestry individuals
Response to statin therapy (LDL cholesterol subfractions)
3,496 European ancestry cases, 5,186 European ancestry controls, 1,588 Chinese ancestry cases, 3,546 Chinese ancestry controls
5,134 European ancestry cases, 5,633 European ancestry controls, 5,151 Chinese ancestry cases, 5,152 Chinese ancestry controls
Suicide in bipolar disorder
959 European ancestry individuals
Affymetrix, Illumina [2659407] (imputed)
Polychlorinated biphenyl levels
922 European ancestry individuals
Educational attainment
106,736 European ancestry individuals
642 European ancestry cases
363 Chinese ancestry cases
13,372 African American individuals
Affymetrix, Illumina [2954965] (imputed)
Crohn's disease-related phenotypes
up to 1,090 Southern European ancestry Crohn's disease cases
up to 1,296 Southern European ancestry Crohn's disease cases
Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection
356 European ancestry cases, 447 European ancestry controls
92 European ancestry cases, 179 European ancestry controls
640 European ancestry cases, 41,607 European ancestry controls
Androgen levels
3,225 European ancestry male individuals
109 Amish cases, 689 Amish controls
1,483 European ancestry cases, 1,683 European ancestry controls
Barrett's esophagus
Up to 1,852 European ancestry cases, 5,172 European ancestry controls
5,986 European ancestry cases, 12,825 European ancestry controls
Glioma (high-grade)
1,013 European ancestry cases, 6,595 European ancestry controls
631 European ancestry cases, 1,141 European ancestry controls
Affymetrix, Illumina [2362330] (imputed)
18,596 European ancestry individuals
23,279 European ancestry individuals
Affymetrix, Illumina, Perlegen [at least 2500000] (imputed)
2,748 European ancestry cases
1,666 Japanese ancestry cases, 3,198 Japanese ancestry controls
11,412 Japanese ancestry cases, 28,397 Japanese ancestry controls
Serum lipase activity
3,966 European ancestry individuals
1,444 European ancestry individuals
High serum lipase activity
981 European ancestry cases, 2985 European ancestry controls
346 European ancestry cases, 1098 European ancestry controls
Carotid plaque burden (smoking interaction)
665 Hispanic individuals
264 Hispanic indivduals
Adverse response to radiation therapy
79 European, African, Asian, and Hispanic ancestry cases, 241 European, African, Asian, and Hispanic ancestry controls
107 European, African, Asian, and Hispanic ancestry cases, 671 European, African, Asian, and Hispanic ancestry controls
6,621 European ancestry cases, 6,939 European ancestry controls
22,957 European ancestry cases, 23,234 European ancestry controls, 420 East Asian ancestry cases, 433 East Asian ancestry controls, 112 African American cases, 298 African American controls, 7,140 cases, 5,455 controls
61 cases and 2,530 controls from 1,232 families
1,819 cases and 1,969 controls from 2,265 families, 9,966 European ancestry cases, 8,935 European ancestry controls, 1,459 African American cases, 3,437 African American controls, 951 Japanese ancestry cases, 894 Japanese ancestry controls
Conotruncal heart defects
537 European ancestry case-parent trios, 213 case-parent trios
348 European ancestry case-parent trios, 10 case-parent trios
Obesity
164 European ancestry morbidly obese individuals, 163 European ancestry lean individuals
4,674 European ancestry morbidly obese individuals, 5,663 European ancestry lean individuals
573 European ancestry cases, 481 European ancestry controls
2,907 European ancestry cases, 14,860 European ancestry controls
2,677 European ancestry cases, 8,629 European ancestry controls, 458 Japanese ancestry cases, 421 Japanese ancestry controls
2,763 Bangladeshi ancestry females, 2,591 Bangladeshi ancestry males
Body mass index (change over time)
2,643 Bangladeshi ancestry females, 2,340 Bangladeshi ancestry males
2,754 Bangladeshi ancestry females, 2,590 Bangladeshi ancestry males
Underweight status
953 Bangladeshi ancestry underweight females, 1,269 Bangladeshi ancestry normal weight females, 1,146 Bangladeshi ancestry underweight males, 1,106 normal weight males
Overweight status
531 Bangladeshi ancestry overweight females, 1,269 Bangladeshi ancestry normal weight females, 338 Bangladeshi ancestry overweight males, 1,106 Bangladeshi ancestry normal weight males
5,626 European ancestry cases, 7,817 European ancestry controls
14,037 European ancestry cases, 15,937 European ancestry controls
Cleft plate (environmental tobacco smoke interaction)
259 Asian ancestry cases and their unaffected parents, 272 European ancestry cases and their unaffected parents, 19 cases and their unaffected parents
Blood pressure variability
3,802 European ancestry individuals
3,900 European ancestry individuals
9,538 European ancestry individuals
968 European ancestry individuals
AIDS progression
275 European ancestry seropositive non-progressors, 86 European ancestry seropositive rapid progressors, 1,352 European ancestry seronegative controls
(see Fellay 2007)
Mammographic density (dense area)
7,600 European ancestry individuals
343 European ancestry individuals, 1,472 Old Order Amish individuals, 8,564 individuals
Mammographic density (non-dense area)
Percent mammographic density
7,916 European ancestry individuals
494 European ancestry cases, 5,628 European ancestry controls
5,383 European ancestry cases, 13,033 European ancestry controls
Affymetrix, Illumina [1579307] (imputed)
Blood pressure (response to antihypertensive medication)
265 Japanese ancestry individuals
79 Japanese ancestry individuals
Complement C3 and C4 levels
1,999 Han Chinese ancestry male individuals
1,496 Han Chinese ancestry male individuals
6,608 European ancestry individuals
Glaucoma (primary angle closure)
1,281 East Asian ancestry cases, 1,987 East Asian ancestry controls, 337 South Indian ancestry cases, 2,538 South Indian ancestry controls, 236 South East Asian ancestry cases, 5,083 South East Asian ancestry controls
1,545 East Asian ancestry cases, 3,756 East Asian ancestry controls, 165 Saudi Arabian ancestry cases, 175 Saudi Arabian ancestry controls, 127 European ancestry cases, 4,703 European ancestry controls, 80 Indian ancestry cases, 309 Indian ancestry controls
Mathematical ability in children with dyslexia
200 European ancestry cases
510 European ancestry cases
4,600 European ancestry cases, 2,941 European ancestry controls
7,779 European ancestry cases, 7,623 European ancestry controls
Prostate cancer aggressiveness
4,545 European ancestry cases
7,973 European ancestry cases
524 European ancestry JAK2 negative cases, 2,674 European ancestry controls
1,383 European ancestry JAK2 negative cases, 4,609 European ancestry controls, 526 JAK2 negative cases, 5,506 controls
Response to interferon beta in multiple sclerosis
74 European ancestry responders, 42 European ancestry non-responders
346 European ancestry responders, 254 European ancestry non-responders, 137 responders, 144 non-responders
Recalcitrant atopic dermatitis
246 Korean ancestry child cases, 551 Korean ancestry adult controls
Lifespan
679 female individuals
432 male individuals
Response to temozolomide
516 European ancestry lymphoblastoid cell lines
Height adjusted BMI
5,809 children
2,089 European ancestry children
Sarcoidosis
564 European ancestry cases, 1,575 European ancestry controls
3,080 European ancestry cases, 3,659 European ancestry controls
2,175 European ancestry individuals
4,866 European ancestry individuals
up to 2,860 European ancestry children
Affymetrix, Illumina [up to 583824] (imputed)
Ossification of the posterior longitudinal ligament of the spine
1,112 Japanese ancestry cases, 6,810 Japanese ancestry controls
548 Japanese ancestry cases, 6,469 Japanese ancestry controls
2,994 Japanese ancestry individuals
6,805 Korean ancestry individuals
18,245 European ancestry females
Mathematical ability
419 European ancestry individuals with high mathematical ability, 183 European ancestry individuals with low mathematical ability
Lipid traits
839 European ancestry individuals
up to 5,248 European ancestry individuals
up to 1,405 Han Chinese ancestry cases, up to 2,650 Han Chinese ancestry controls
356 Han Chinese ancestry cases, 629 Han Chinese ancestry controls
33,533 European ancestry individuuals
38,360 European ancestry individuuals
Affymetrix, Illumina [~ 2600000] (imputed)
Recombination measurement (females)
6,041 European ancestry female individuals
Recombination measurement (males)
4,389 European ancestry male individuals
458 European ancestry low General cognitive ability children, 402 European ancestry high General codnitive ability children
3,195 European ancestry children
Schizophrenia or bipolar disorder
Up to 4,528 European ancestry schizophrenia cases, up to 4,841 schizophrenia cases, up to 7,362 European ancestry bipolar disorder cases, up to 3,048 bipolar disorder cases, up to 11,637 European ancestry controls, up to 7,786 controls
Affymetrix, Illumina [~ 1100000] (imputed)
205 Japanese ancestry cases, 241 Japanese ancestry controls
632 Japanese ancestry cases, 908 Japanese ancestry controls
8,487 European ancestry cases aged 25 years or older, 23,481 European ancestry controls aged 25 years or older, 907 European ancestry cases aged less than 25 years, 4,733 European ancestry controls aged less than 25 years, 3,076 Asian ancestry cases aged 25 years or older, 6,219 Asian ancestry controls aged 25 years or older, 247 Chinese ancestry cases aged less than 25 years, 670 Chinese ancestry controls aged less than 25 years
857 European ancestry familial cases, 440 idiopathic cases
747 European ancestry idiopathic cases
Skin fluorescence
1,082 European ancestry individuals with type 1 diabetes, 8,721 European ancestry individuals
202 European ancestry individuals with type 1 diabetes, 318 European ancestry individuals with type 2 diabetes, 515 European ancestry individuals
5,141 European ancestry cases, 54,444 European ancestry controls
Up to 5,470 European ancestry cases, up to 7,583 European ancestry controls
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia
363 European ancestry individuals
515 individuals
Up to 1,364 Han Chinese ancestry cases, up to 3,028 Han Chinese ancestry controls
4,167 Han Chinese ancestry cases, 7,196 Han Chinese ancestry controls
397 European ancestry cases, 1,211 controls
1,408 cases, 2,426 controls, 875 European ancestry cases, 832 European ancestry controls
Paclitaxel-induced neuropathy
143 European ancestry individuals
Memory performance
1,241 European ancestry individuals
Pain
1,308 European ancestry female cases, 5,791 European ancestry female controls
1,480 European ancestry female cases, 7,989 European ancestry female controls
542 European ancestry cases, 542 European ancestry controls
868 European ancestry cases, 1,389 European ancestry controls
Lung Cancer (DNA repair capacity)
914 European ancestry non-small cell lung cancer cases, 860 European ancestry controls
679 European ancestry ancestry non-small cell lung cancer cases, 695 European ancestry controls
382 Han Chinese ancestry young-onset-hypertensive cases
559 Han Chinese ancestry young-onset-hypertensive cases
2,088 European ancestry cases, 1,612 African American and African Caribbean cases, 1,688 Hispanic cases
2,727 European ancestry cases, 2,147 African American and African Caribbean cases, 2,299 Hispanic cases
Affymetrix, Illumina [> 2000000] (imputed)
Fractures (vertebral)
329 European ancestry cases, 2,666 European ancestry controls
5,619 European ancestry cases, 20,598 European ancestry controls, 101 Korean ancestry cases, 1,193 Korean ancestry controls
2,151 European ancestry individuals
16,094 European ancestry individuals
1,235 European ancestry aggressive cases, 1,599 European ancestry controls
1,215 European ancestry aggressive cases, 2,213 European ancestry non-aggressive cases, 1,208 European ancestry controls, 1,034 aggressive cases, 921 non-aggressive cases, 2,231 controls
Affymetrix, Illumina [~ 2000000] (imputed)
Allergic dermatitis (nickel)
up to 24 Korean ancestry cases, 52 Korean ancestry controls
Response to efavirenz-containing treatment in HIV 1 infection (virologic failure)
Up to 737 European ancestry individuals, Up to 545 Black individuals, Up to 314 Hispanic individuals
Response to abacavir-containing treatment in HIV-1 infection (virologic failure)
Up 346 European ancestry individuals, Up to 265 Black individuals, Up to 175 Hispanic individuals
605 European ancestry cases, 1,179 European ancestry controls
Affymetrix, Illumina [2092686] (imputed)
25 European ancestry C9orf72-positive cases, 1,179 European ancestry controls
Affymetrix, Illumina [1172473] (imputed)
Amyotrophic lateral sclerosis (age of onset)
Affymetrix, Illumina [2093056] (imputed)
642 South African coloured cases, 91 South African coloured controls
642 South African coloured cases, 91 South African coloured controls, (see Thye 2010)
4,829 European ancestry individuals from 586 families with exceptional longevity
Asymmetrical dimethylarginine levels
5110 European ancestry individuals
Affymetrix, Illumina [10085758] (imputed)
Symmetrical dimethylarginine levels
Serum dimethylarginine levels (asymmetric/symetric ratio)
5,789 European ancestry cases, 10,056 European ancestry controls
6,114 European ancestry cases, 9,920 European ancestry controls
Mesial temporal lobe epilepsy with hippocampal sclerosis
up to 1,018 European ancestry cases, 7,552 European ancestry controls
959 European ancestry cases, 3,591 European ancestry controls
Personality dimensions
1,089 Korean ancestry females
2,090 Korean ancestry individuals
Menarche (age at onset)
Up to 182,413 European ancestry females
Affymetrix, Illumina [2441815] (imputed)
Febrile seizures
929 European ancestry MMR vaccine-related febrile seizures cases, 1,070 European ancestry MMR vaccine-unrelated febrile seizures cases, 4,118 European ancestry controls
Up to 408 European ancestry MMR vaccine-related febrile seizures cases, Up to 1,034 European ancestry MMR vaccine-unrelated febrile seizures cases, Up to 1,645 European ancestry controls
Febrile seizures (MMR vaccine-unrelated)
1,070 European ancestry cases, 4,118 European ancestry controls
Up to 1,034 European ancestry cases, Up to 1,645 European ancestry controls
Febrile seizures (MMR vaccine-related)
929 European ancestry cases, 4,118 European ancestry controls
Up to 408 European ancestry cases, Up to 1,645 European ancestry controls
Myopia (severe)
1,603 East Asian ancestry cases, 3,427 East Asian ancestry controls
1,241 East Asian ancestry cases, 3,559 East Asian ancestry controls
Serum alpha1-antitrypsin levels
1,392 European ancestry individuals
12,518 European ancestry individuals
263 European ancestry left-handed individuals, 2,092 European ancestry right-handed individuals
173 European ancestry left-handed individuals, 1,412 European ancestry right-handed individuals
Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma)
2,331 Han Chinese ancestry lung cancer cases, 1,006 Han Chinese ancestry non-cardia gastric cancer cases, 2,031 Han Chinese ancestry esophageal squamous-cell carcinoma cases, 4,006 Han Chinese ancestry controls
2,665 Han Chinese ancestry lung cancer cases, 3,330 Han Chinese ancestry non-cardia gastric cancer cases, 3,006 Han Chinese ancestry esophageal squamous-cell carcinoma cases, 11,436 Han Chinese ancestry controls
Response to methotrexate in juvenile idiopathic arthritis
694 European ancestry child cases
2,322 European ancestry individuals from 118 families, 2,593 European ancestry individuals
Anti-saccade response
4,469 European ancestry twins and their parents
1,839 Han Chinese ancestry cases, 1,873 Han Chinese ancestry controls
15,979 East Asian ancestry cases, 19,360 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls
82,438 East Asian ancestry individuals, 4,301 South East Asian ancestry individuals
Up to 47,352 East Asian ancestry individuals
3,016 African American cases, 2,745 African American controls
3,533 African ancestry cases, 11,046 African ancestry controls
Body mass (lean)
1,627 Han Chinese individuals
Colorectal cancer (calcium intake interaction)
9,006 European ancestry cases, 9,503 European ancestry controls
Coronary artery disease-related phenotypes
667 Korean ancestry cases
853 Korean ancestry cases
Parent of origin effect on language impairment (paternal)
153 European ancestry case-parent trios, 54 European ancestry case-mother duos, 12 European ancestry case-father duos, 18 European ancestry cases
Parent of origin effect on language impairment (maternal)
193 European ancestry case-mother duos, 75 European ancestry cases, 45 European ancestry mothers of cases
968 European ancestry cases, 40,000 European ancestry controls
15,506 European ancestry individuals
Reading disability and language impairment
174 European ancestry cases, 4,117 European ancestry controls
440 European ancestry individuals
Political ideology
11,388 European ancestry individuals from 6,758 families
3,178 Chinese ancestry individuals, 2,138 Malay ancestry individuals, 2,124 Asian Indian ancestry individuals
2,473 Chinese ancestry individuals, 2,747 Japanese ancestry individuals
Up to 26,836 European ancestry individuals
Up to 42,519 European ancestry individuals
Affymetrix, Illumina [~ 2700000] (imputed)
Psychosis (atypical)
47 Japanese ancestry cases, 882 Japanese ancestry controls
295 European ancestry cases, 196 European ancestry controls
143 African American cases, 462 African American controls
Puberty onset (genital enlargement)
3,769 European ancestry boys
208 European ancestry individuals
Puberty onset (breast development)
6,147 European ancestry girls
Puberty onset
6,147 European ancestry girls, 3,769 European ancestry boys
Up to 1,376 European ancestry individuals
Colorectal adenoma (advanced)
139 European ancestry cases, 1,267 European ancestry controls
4,175 European ancestry cases, 5,036 European ancestry controls
Opioid sensitivity
118 Japanese ancestry individuals
235 Japanese ancestry individuals
Myopia (pathological)
187 European ancestry cases, 1064 European ancestry controls
2,121 European ancestry cases, 39,614 European ancestry controls
2,506 European and other ancestry cases, 15,101 European and other ancestry controls
Bronchopulmonary dysplasia
117 African American newborn cases, 108 African American newborn controls, 448 Hispanic newborn cases, 460 Hispanic newborn controls, 74 Asian or Pacific Islander ancestry newborn cases, 93 Asian or Pacific Islander ancestry newborn controls, 174 European ancestry newborn cases, 216 European ancestry newborn controls, 14 newborn cases, 22 newborn controls
371 newborn cases, 424 newborn controls
Recombination measurement
30,033 African American individuals
Affymetrix, Illumina [3058149] (imputed)
13,974 European ancestry females
840 European ancestry females
Narcolepsy
1,189 Chinese ancestry cases, 1,997 Chinese ancestry controls
2,693 European ancestry cases, 11,495 European ancestry controls
Narcolepsy (onset before 2009 H1N1 influenza pandemic)
up to 893 Chinese ancestry cases with onset before the 2009 H1N1 influenza pandemic, up to 373 Chinese ancestry cases with onset after the 2009 H1N1 influenza pandemic
Narcolepsy (age of onset)
at least 1,000 Chinese ancestry cases
1,821 cases, 2,258 controls
538 cases, 556 controls
904 Ashkenazi Jewish cases, 1,640 Ashkenazi Jewish controls
3,944 European ancestry cases, 3,049 European ancestry controls, 921 African American cases, 954 African American controls, 550 Japanese ancestry cases, 530 Japanese ancestry controls
1,130 Ashkenazi Jewish cases, 2,611 Ashkenazi Jewish controls
306 Ashkenazi Jewish cases, 2,583 Ashkenazi Jewish controls
Affymetrix, Illumina [1069161] (imputed)
Lean body mass
269 Japanese ancestry individuals
1,081 Japanese ancestry individuals
1,277 European ancestry cases, 1,488 European ancestry controls
1,365 European ancestry cases, 1,396 European ancestry controls
Cystic fibrosis-related diabetes
644 cystic fibrosis-related diabetes cases, 2,415 cystic fibrosis controls
124 cystic fibrosis-related diabetes cases, 570 cystic fibrosis controls
Neuroblastoma
2,101 European ancestry cases, 4,202 European ancestry controls
351 European ancestry cases, 780 European ancestry controls, 365 African American cases, 2,491 African American controls
C-reactive protein
8,280 African American female individuals, 3,548 Hispanic female individuals
3,787 African American female individuals, 3,548 Hispanic female individuals, 5,656 European ancestry individuals
Smoking behavior
11,696 Japanese ancestry smokers
5,462 Japanese ancestry smokers
Tourette's syndrome or obsessive-compulsive disorder
1,310 Ashkenazi Jewish, South African Afrikaner ancestry, and other European ancestry OCD cases, 834 Ashkenazi Jewish, French Canadian and other European ancestry Tourette's Syndrome cases, 579 Ashkenazi Jewish, South African Afrikaner ancestry, French Canadian and other European ancestry OCD and Tourette's syndrome cases, 4,975 European ancestry controls, 338 Ashkenazi Jewish controls, 196 French Canadian controls, 158 South African Afrikaner ancestry controls, 290 European ancestry OCD parent-child trios
1,384 Lebanese ancestry cases, 1,902 Lebanese ancestry controls
7,738 Asian ancestry individuals, 27,558 European ancestry individuals
858 Mexican American family members and individuals
212 Japanese ancestry chronic hepatitis C with hepatocellular carcinoma cases, 765 Japanese ancestry chronic hepatitis C without hepatocellular carcinoma cases
710 Japanese ancestry chronic hepatitis C with hepatocellular carcinoma cases, 1,625 Japanese ancestry chronic hepatitis C without hepatocellular carcinoma cases
1,044 Han Chinese ancestry cases, 1,172 Han Chinese ancestry controls
1,452 Han Chinese ancestry cases, 2,803 Han Chinese ancestry controls
3,181 European ancestry cases, 8,075 European ancestry controls, 1,423 Japanese ancestry cases, 1,318 Japanese ancestry controls
1,044 Japanese ancestry, 4,017 Japanese ancestry controls
Schizophrenia (treatment resistant)
79 European ancestry treatment resistant cases, 95 European ancestry non-treatment resistant cases
70 European ancestry treatment resistant cases, 125 European ancestry non-treatment resistant cases
Rheumatoid factor
3,170 Japanese ancestry individuals
Anti-citrullinated peptide antibody
Up to 70,389 European ancestry individuals, up to 672 Orcadian individuals
Up to 33,316 European ancestry individuals
Chronic mucus hypersecretion in chronic obstructive pulmonary disease
338 European ancestry cases, 511 European ancestry controls
1,198 European ancestry cases, 1,908 European ancestry controls
Chronic mucus hypersecretion
342 European ancestry cases, 1,006 European ancestry controls
130 European ancestry cases, 2,313 European ancestry controls
200 Han Chinese ancestry cases, 200 Han Chinese ancestry controls
391 Han Chinese ancestry cases, 381 Han Chinese ancestry controls
Response to radiotherapy in prostate cancer (toxicity)
Up to 652 European ancestry cases
849 European ancestry cases
4,877 European ancestry females
1,145 European ancestry females, 1,690 females
Sleep time
2,322 European ancestry individuals
Sleep quality
2,315 European ancestry individuals
Sleep depth
2,314 European ancestry individuals
2,278 European ancestry individuals
2,267 European ancestry individuals
Sleep latency
2,280 European ancestry individuals
2,001 European ancestry individuals
2,627 Japanese ancestry cases, 3,797 Japanese ancestry controls, 1,893 African American cases, 4,703 African American controls
16,823 European ancestry cases, 18,211 European ancestry controls
Cotinine glucuronidation
437 European ancestry current smoker individuals, 364 African American current smoker individuals, 453 Latino current smoker individuals, 674 Japanese ancestry current smoker individuals, 311 Native Hawaiian ancestry current smoker individuals
Nicotine glucouronidation
Angioedema in response to angiotensin-converting enzyme inhibitor
175 European, African American and other ancestry ACE inhibitor-associated angioedema cases, 489 European, African American and other ancestry ACE inhibitor-exposed controls
19 European, African American and other ancestry ACE inhibitor-associated angioedema cases, 57 European, African American and other ancestry ACE inhibitor-exposed controls
Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction)
382 European ancestry mild cognitive impairment cases, 114 European ancestry Alzheimer's disease cases, 194 European ancestry controls
Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels)
300 European ancestry Escitalpram treated individuals, 130 European ancestry Citalopram treated individuals
637 European ancestry cases, 1,233 European ancestry controls
3,121 European ancestry cases, 4,284 European ancestry controls
988 European ancestry cases, 198 African American cases, 100 Hispanic cases
Response to angiotensin II receptor blocker treatment (losartan) (change in systolic blood pressure levels)
372 European ancestry hypertensive individuals
216 European ancestry hypertensive individuals
Confectionary intake
939 Japanese ancestry individuals
4,491 Japanese ancestry individuals
CYP3A4 enzyme activity
310 European ancestry female twin individuals
Up to 31,211 European ancestry individuals
10,553 European ancestry individuals, 687 Orcadian individuals
4,208 European ancestry cases, 109,408 European ancestry controls
up to 1,480 European ancestry cases, up to 4,610 European ancestry controls
Cytomegalovirus antibody response
1,485 European ancestry sero-postitive individuals, 648 European ancestry sero-negative individuals
Sasang constitutional medicine type
60 Korean ancestry individuals
Binge eating behaviour in bipolar disorder
206 European ancestry cases with binge eating behavior, 723 European ancestry cases without binge eating behavior
70 European ancestry cases with binge eating behavior, 758 European ancestry cases without binge eating behavior
Binge eating behaviour and bipolar disorder
206 European ancestry cases with binge eating behavior, 723 European ancestry cases without binge eating behavior, 1,034 European ancestry controls
70 European ancestry cases with binge eating behavior, 758 European ancestry cases without binge eating behavior, 832 European ancestry controls
405 European ancestry cases, 127 African American cases, 248 cases, 2,330 European ancestry genetic generalised epilepsy cases, 81 African American genetic generalised epilepsy cases, 195 genetic generalised epilepsy cases, 3,277 European ancestry focal epilepsy cases, 222 African American focal epilepsy cases, 487 Han Chinese ancestry focal epilepsy cases, 1,324 focal epilepsy cases, up to 17,441 European ancestry controls, up to 2,843 African American controls, up to 2,875 Han Chinese ancestry controls, up to 2,998 controls
Rheumatoid arthritis (ACPA-negative)
1,148 European ancestry cases, 6,008 European ancestry controls
774 European ancestry cases, 1,079 European ancestry controls
Elevated serum carcinoembryonic antigen levels
1,999 Chinese ancestry individuals
Lung cancer (smoking interaction)
1,506 Han Chinese ancestry smoker cases, 825 Han Chinese ancestry non-smoker cases, 1,309 Han Chinese ancestry smoker controls, 1,768 Han Chinese ancestry non-smoker controls
912 Han Chinese ancestry smoker cases, 622 Han Chinese ancestry non-smoker cases, 572 Han Chinese ancestry smoker controls, 917 Han Chinese ancestry non-smoker controls
1,582 European ancestry cases, 5,203 European ancestry controls
6,101 European ancestry cases, 9,194 European ancestry controls
Depression (age of onset)
Up to 2,746 European ancestry cases, 1,584 European ancestry controls
1383 European ancestry cases, 1403 European ancestry controls
Bitter taste perception
503 Brazilian ancestry individuals
104 Brazilian ancestry individuals
P wave duration
16,468 European ancestry individuals
PR segment
2,503 European ancestry individuals, 1,627 Han Chinese ancestry individuals
Systemic lupus erythematosus and Systemic sclerosis
up to 2,761 European ancestry systemic sclerosis cases, 769 European ancestry systemic lupus erythematosus cases, 7,381 European ancestry controls
up to 1,578 European ancestry systemic sclerosis cases, 1,727 European ancestry systemic lupus erythematosus cases, 6,893 European ancestry controls
9,491 European ancestry individuals, up to 2,053 African American individuals
284 European ancestry individuals
3,280 European ancestry individuals
1,367 European ancestry individuals
837 Mexican American cases, 436 Mexican American controls
967 Mexican ancestry cases, 343 Mexican ancestry controls
2,906 European ancestry cases, 3,416 European ancestry controls
8,161 European ancestry cases, 9,101 European ancestry controls
Sickle cell anemia (haemolysis)
1,117 individuals
213 African ancestry, West African ancestry and Afro-Caribbean individuals, 745 individuals
665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls
2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls
Iris characteristics
2,121 European ancestry individuals
499 European ancestry adolescent twins and siblings, 73 European ancestry adult individuals
632 Mexican American individuals
855 Friuli Venezia Giulia (founder/genetic isolate) individuals
Nasopharyngeal carcinoma (SNP x SNP interaction)
277 Han Chinese ancestry cases, 285 Han Chinese ancestry controls
181 Han Chinese ancestry cases, 187 Han Chinese ancestry controls
Plasma plasminogen activator levels
26,217 European ancestry individuals, 712 Orcadian individuals
4,487 European ancestry individuals
Affymetrix, Illumina [2455857] (imputed)
Facial pigmentation
2,844 European ancestry individuals
8,842 Korean ancestry individuals
7,861 Korean ancestry individuals
Blood pressure response to hydrochlorothiazide in hypertension
485 European ancestry cases
1,545 European ancestry cases
Lead levels in blood
5,433 individuals
Homoarginine levels
5,143 European ancestry individuals
1,474 European ancestry individuals
Affymetrix, Illumina [2543887] (imputed)
4,270 European ancestry individuals
13,414 European ancestry individuals
Acoustic startle blink response
3,323 European ancestry twins and their parents
Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia
53 European ancestry cases with peripheral neuropathy, 156 cases without peripheral neuropathy, 10 African ancestry cases with peripheral neuropathy, 33 African ancestry cases without peripheral neuropathy, 1 Asian ancestry case with peripheral neuropathy, 1 Asian ancestry case without peripheral neuropathy, 14 Hispanic cases with peripheral neuropathy, 30 Hispanic cases without peripheral neuropathy, 8 cases with peripheral neuropathy, 15 cases without peripheral neuropathy
Gastritis
977 Korean ancestry female cases, 3,622 Korean ancestry female controls, 804 Korean ancestry male cases, 3,335 Korean ancestry male controls
2,179 Chinese ancestry individuals, 2,275 Malay ancestry individuals, 2,238 Asian Indian ancestry individuals
1,593 Japanese ancestry cases, 7,980 Japanese ancestry controls
1,167 Japanese ancestry cases, 7,178 Japanese ancestry controls
1,484 Japanese ancestry cases, 1,188 Japanese ancestry controls
1,530 East Asian ancestry cases, 6,230 East Asian ancestry controls, 1,064 Southern Indian ancestry cases, 3,536 Southern Indian ancestry controls, 140 Hispanic cases, 233 Hispanic controls, 347 Middle Eastern ancestry cases, 1,108 Middle Eastern ancestry controls, 3,588 European ancestry cases, 9,012 European ancestry controls, 102 South African Black cases, 379 South African Black controls, 50 Uighur cases, 49 Uighur controls, 80 cases, 180 controls
Gene methylation in lung tissue
1,163 European ancestry smoker individuals
718 European ancestry smoker individuals
Peanut allergy
316 European ancestry child cases, 144 European ancestry non-allergic non-sensitized normal child controls, 589 European ancestry uncertain phenotype child controls, 1,148 European ancestry uncertain phenotype adult controls
62 European ancestry child cases, 69 European ancestry child controls, 24 child cases, 58 child controls
Milk allergy
291 European ancestry child cases, 144 European ancestry non-allergic non-sensitized normal child controls, 614 European ancestry uncertain phenotype child controls, 1,148 European ancestry uncertain phenotype adult controls
Egg allergy
217 European ancestry child cases, 144 European ancestry non-allergic non-sensitized normal child controls, 688 European ancestry uncertain phenotype child controls, 1,148 European ancestry uncertain phenotype adult controls
Food allergy
671 European ancestry child cases, 144 European ancestry non-allergic non-sensitized child controls, 234 European ancestry uncertain phenotype child controls, 1,148 European ancestry uncertain phenotype adult controls
Parkinson disease and lewy body pathology
484 European ancestry cases, 1,145 European ancestry controls
Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement
117 Japanese ancestry cases, 691 Japanese ancestry controls
43 East Asian ancestry cases, 278 East Asian ancestry controls, 20 Indian ancestry cases, 56 Indian ancestry controls, 39 Brazilian ancestry cases, 135 Brazilian ancestry controls
Clozapine-induced cytotoxicity
90 European ancestry lymphoblast cell lines
4,470 Japanese ancestry cases, 3,071 Japanese ancestry controls
10,692 Japanese ancestry cases, 9,597 Japanese ancestry controls, 6,980 European ancestry cases, 8,615 European ancestry controls
20 European ancestry peritoneal endometriosis cases, 20 European ancestry endometrioma cases, 20 European ancestry deep infiltrating endometriosis cases, 20 European ancestry controls
42 European ancestry peritoneal endometriosis cases, 121 European ancestry endometrioma cases, 96 European ancestry deep infiltrating endometriosis cases, 288 European ancestry controls
Verbal declarative memory
Up to 27,337 European ancestry individuals, up to 472 Korkulan individuals, up to 1,267 Erasmus Rucphen Family individuals
Up to 10,617 European ancestry individuals, up to 3,811 African American individuals
3,253 Korean ancestry cases, 5,589 Korean ancestry controls
Alzheimer's disease (survival time)
983 cases
Cisplatin-induced hearing loss in brain tumor patients
156 European ancestry cases, 82 African American and other ancestry cases
68 cases
Exudative age-related macular degeneration
2,119 East Asian ancestry cases, 5,691 East Asian ancestry controls
4,226 East Asian ancestry cases, 10,289 East Asian ancestry controls
Breast cancer in childhood cancer survivors treated with less than 10 gray radiotherapy
69 European ancestry cases, 2,144 European ancestry controls
Affymetrix, Illumina [16958466] (imputed)
Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy
131 European ancestry cases, 493 European ancestry controls
Breast cancer in childhood cancer survivors
207 European ancestry female cases, 2,774 European ancestry female controls
2146 East Asian ancestry individuals
Alcohol consumption over the past year
20,328 European ancestry individuals
6,377 European ancestry male cases, 5,794 European ancestry female cases, 22,243 European ancestry male controls, 34,619 European ancestry female controls
12,938 European ancestry male cases, 8,553 European ancestry female cases, 904 Pakistani ancestry male cases, 274 Pakistani ancestry female cases, 30,273 European ancestry male controls, 25,374 European ancestry female controls, 2,088 Pakistani ancestry male controls, 384 Pakistani ancestry female controls
Affymetrix, Illumina [up to 2500000] (imputed)
Major depression and alcohol dependence
3,041 African American individuals, 1,618 European ancestry individuals
1,612 African American individuals, 1,551 European ancestry individuals
5,454 African American cases, 474 West African cases, 4,274 African American and African ancestry cases, 6,328 African American controls, 458 West African controls, 4,024 African American and African ancestry controls
Affymetrix, Illumina [17013228] (imputed)
Idiopathic osteonecrosis of the femoral head
1,547 Japanese ancestry cases, 59,103 Japanese ancestry controls
602 European ancestry cases, 3,366 European ancestry controls
2,158 cases, 5,195 controls
Cow's milk allergy
169 European ancestry cases, 2,387 European ancestry controls
390 European ancestry cases, 2,510 European ancestry controls
497 European ancestry cases, 2,387 European ancestry controls
1,050 European ancestry cases, 2,510 European ancestry controls
230 European ancestry cases, 2,387 European ancestry controls
438 European ancestry cases, 2,510 European ancestry controls
Hen's egg allergy
288 European ancestry cases, 2,387 European ancestry controls
416 European ancestry cases, 2,510 European ancestry controls
White coat effect (clinic systolic blood pressure minus home systolic blood pressure)
295 Japanese ancestry individuals
236 Japanese ancestry individuals
White coat effect (clinic diastolic blood pressure minus home diastolic blood pressure)
Late-onset Alzheimer's disease
966 Quebec (founder/genetic isolate) ancestry cases, 977 Quebec (founder/genetic isolate) controls
340 cases, 195 controls
997 European ancestry individuals
338 Arab, South Asian and Filipino ancestry individuals
Nonalcoholic steatohepatitis-derived hepatocellular carcinoma
58 Japanese ancestry cases, 7,672 Japanese ancestry controls
Brunt stage in nonalcoholic fatty liver disease
474 Japanese ancestry cases
Brunt grade in nonalcoholic fatty liver disease
567 Japanese ancestry cases
Hepatocyte fat droplet content in nonalcoholic fatty liver disease
834 Japanese ancestry cases
902 Japanese ancestry cases, 7,672 Japanese ancestry controls
BMI x dairy intake interaction (1df interaction test)
up to 25,513 European ancestry individuals
up to 17,675 European ancestry individuals
954 African American individuals
480 African American individuals
Menopause (age at onset)
up to 69,626 European ancestry women
up to 2,545 European ancestry women
up to 46,638 European ancestry women
Genome-wide genotyping array, Exome genotyping array [Exome array]
2,285 European ancestry cases, 9,364 European ancestry controls
462 European ancestry cases, 9,364 European ancestry controls
Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis)
2,282 European ancestry Graves disease cases, 451 European ancestry Hashimoto's thyroiditis cases, 9364 European ancestry controls
Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia
74 European ancestry cases, 241 European ancestry controls
1,5-anhydroglucitol levels
7,550 European ancestry individuals
8,790 European ancestry individuals, 2,030 African American individuals
10,784 European ancestry cases, 20,406 European ancestry controls
3,182 European ancestry cases, 6,301 European ancestry controls
Preterm birth (maternal effect) (maternal pre-pregnancy BMI interaction)
329 African American normal weight preterm birth mothers, 514 African American normal weight term birth mothers, 463 African American overweight or obese preterm birth mothers, 580 African American overweight or obese term birth mothers
Affymetrix, Illumina [9929081] (imputed)
Preterm birth (maternal effect)
698 African American preterm birth mothers, 1,035 African American term birth mothers
307 African American preterm birth mothers, 475 African American term birth mothers, 318 European ancestry preterm birth mothers, 365 European ancestry term birth mothers
Spontaneous preterm birth (maternal effect)
461 African American spontaneous preterm birth mothers, 1,035 African American term birth mothers
Gestational age at birth (maternal effect)
447 African American normal weight term birth mothers, 498 African American overweight or obese term birth mothers, 268 African American normal weight preterm birth mothers, 373 African American overweight or obese preterm birth mothers
67 African American normal weight term birth mothers, 82 African American overweight or obese term birth mothers, 61 African American normal weight preterm birth mothers, 90 African American overweight or obese preterm birth mothers, 247 European ancestry normal weight term birth mothers, 118 European ancestry overweight or obese term birth mothers, 192 European ancestry normal weight preterm birth mothers, 126 European ancestry overweight or obese preterm birth mothers
5,518 European ancestry cases, 19,055 European ancestry controls
1,801 European ancestry cases, 4,027 European ancestry controls
Multiple keratinocyte cancers
2,106 European ancestry multiple keratinocyte cancer cases, 2,061 European ancestry single keratinocyte cancer cases, 135 European and unknown ancestry multiple keratinocyte cancer cases, 761 European and unknown ancestry single keratinocyte cancer cases
Affymetrix, Illumina [up to 9001799] (imputed)
Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction)
1,562 European ancestry individuals, 538 African American individuals
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)
1,842 European ancestry chronic lymphocytic leukemia cases, 1,465 European ancestry Hodgkin lymphoma cases, 3,790 European ancestry multiple myeloma cases, 7,324 European ancestry controls
Lung function (maximal voluntary ventilation)
Lung function (forced expiratory volume in 1 second)
Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity)
Urinary magnesium-to-creatinine ratio
up to 5,810 European ancestry individuals, up to 1,541 Val Borbera (founder/genetic isolate) individuals, up to 281 Carlantino (founder/genetic isolate) individuals, up to 889 Korcula (founder/genetic isolate) individuals, up to 489 Split (founder/genetic isolate) individuals, up to 195 Vis (founder/genetic isolate) individuals
Fractional excretion of magnesium
5,265 European ancestry individuals, 1,541 Val Borbera (founder/genetic isolate) individuals, 281 Carlantino (founder/genetic isolate) individuals, 889 Korcula (founder/genetic isolate) individuals
Serum magnesium levels
Primary vesicoureteric reflux
1156 European ancestry cases and at least 1156 European ancestry controls from 548 families
1147 European ancestry cases, 3789 European ancestry controls
Blood osmolality (transformed sodium)
45,889 European ancestry individuals, up to 8,765 Asian Indian ancestry individuals, up to 7,215 African ancestry individuals
17,637 European ancestry individuals
Affymetrix, Illumina, Perlegen [~ 2500000] (imputed)
Fibrinogen levels
91,953 European ancestry individuals (imputed to HapMap)
Affymetrix, Illumina [2749429] (imputed)
91,953 European ancestry individuals (imputed to 1000 Genomes)
Affymetrix, Illumina [10883314] (imputed)
2,964 Japanese ancestry case, 61,887 Japanese ancestry controls, 7,481 European ancestry cases, 9,250 European ancestry controls
443 Polish ancestry cases, 934 Polish ancestry controls
120 Polish ancestry cases, 934 Polish ancestry controls
3,290 European ancestry cases, 116,868 European ancestry controls
65,734 cases and controls (see Germain, 2015)
up to 1,456 Han Chinese ancestry cases, up to 2,104 Han Chinese ancestry controls
up to 4,450 Han Chinese ancestry cases, up to 6,014 Han Chinese ancestry controls
1,001 Indo-European ancestry adults
1,713 Indo-European ancestry adults, 690 Indo-European ancestry children, 481 Dravidian ancestry adults, 534 Dravidian ancestry children
Plasma thyroid-stimulating hormone levels
1,680 Danish ancestry children and adolescents
2,129 Danish ancestry children and adolescents
Free thyroxine concentration
1,167 European ancestry opioid-dependent daily injector cases, 161 European ancestry opioid misusers (impeded progression) controls
833 European ancestry opioid-dependent daily injector cases, 476 European ancestry opioid misusers (impeded progression) controls
295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals
80,792 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 7,243 East Asian ancestry individuals, 461 South Asian ancestry individuals
Circulating chromogranin peptide levels
up to 540 European American and Mexican American individuals, up to 1,267 individuals
Adult onset asthma (smoking interaction)
673 European ancestry exposed cases, 651 European ancestry non-exposed cases, 1,434 European ancestry exposed controls, 1,299 European ancestry non-exposed controls
225 European ancestry exposed cases, 141 European ancestry tobacco non-exposed cases, 7,271 European ancestry exposed controls, 4,838 European ancestry non-exposed controls
Adult onset asthma in non-smokers
651 European ancestry cases, 1,299 European ancestry controls
141 European ancestry cases, 4,838 European ancestry controls
Adult onset asthma in ever-smokers
673 European ancestry cases, 1,434 European ancestry controls
225 European ancestry cases, 7,271 European ancestry controls
3,531 Finnish ancestry individuals
7,118 Finnish ancestry individuals
CTACK levels
3,631 Finnish ancestry individuals
Eotaxin levels
8,153 Finnish ancestry individuals
Fibroblast growth factor basic levels
7,565 Finnish ancestry individuals
Granulocyte-colony stimulating factor levels
7,904 Finnish ancestry individuals
Growth-regulated protein alpha levels
3,505 Finnish ancestry individuals
8,292 Finnish ancestry individuals
Interferon gamma levels
7,701 Finnish ancestry individuals
3,309 Finnish ancestry individuals
3,638 Finnish ancestry individuals
Interleukin-2 levels
3,475 Finnish ancestry individuals
Interleukin-2 receptor antagonist levels
3,677 Finnish ancestry individuals
8,124 Finnish ancestry individuals
Interleukin-5 levels
3,364 Finnish ancestry individuals
8,189 Finnish ancestry individuals
3,409 Finnish ancestry individuals
3,526 Finnish ancestry individuals
Interleukin-9 levels
3,634 Finnish ancestry individuals
7,681 Finnish ancestry individuals
Interleukin-13 levels
3,557 Finnish ancestry individuals
7,760 Finnish ancestry individuals
3,636 Finnish ancestry individuals
Macrophage Migration Inhibitory Factor levels
3,494 Finnish ancestry individuals
3,685 Finnish ancestry individuals
12,375 Hispanic/Latino individuals
12,580 Hispanic/Latino individuals
12,586 Hispanic/Latino individuals
12,589 Hispanic/Latino individuals
Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan)
2,434 European ancestry individuals, 2,470 African American individuals, 2,065 Hispanic individuals, 702 Chinese ancestry individuals
3,013 European ancestry individuals
Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan)
Subclinical trait of interstitial lung disease (percentage of high attenuation areas on CT scan)
up to 1,476 Mylopotamos (founder/genetic isolate) individuals, up to 1,737 Pomak (founder/genetic isolate) individuals
Hip bone size adjusted for BMI
747 East Asian ancestry cases, 2,071 East Asian ancestry controls
747 East Asian ancestry gout cases, 747 East Asian ancestry hyperuricemia cases
HIV progression (CD4 and viral load)
556 Motswana ancestry cases
1,027 European American cases, 383 African American cases
Cognitive function
up to 35,298 European ancestry individuals
Affymetrix, Illumina [8037763] (imputed)
3,584 Latino individuals
931 Latino individuals
Adverse response to chemotherapy (congestive heart failure) in breast cancer
51 European American ancestry cases, 794 European American ancestry controls
21 European ancestry cases, 266 European ancestry controls
Response to clopidogrel therapy in coronary heart disease
115 Han Chinese ancestry cases
2,743 Chinese ancestry cases, 3,573 Chinese ancestry controls
5,413 Han Chinese ancestry cases, 12,037 Han Chinese ancestry controls
Systolic blood pressure change trajectories
up to 683 Mexican American individuals from 20 families
Childhood onset asthma (traffic air pollution exposure interaction)
454 European ancestry child cases, 1,080 European ancestry child controls
692 European ancestry child cases, 1,096 European ancestry child controls
Affymetrix, Illumina [2082301] (imputed)
Agoraphobic traits
1,370 German ancestry individuals
6,392 European ancestry individuals
12,194 European and unknown ancestry cases, 28,072 European and unknown ancestry controls
12,366 European and unknown ancestry cases, 33,609 European and unknown ancestry controls
25,042 European and unknown ancestry cases, 34,915 European and unknown ancestry controls
2,499 Hispanic/Latino ancestry cases, 5,247 Hispanic/Latino ancestry controls
Attention deficit hyperactivity disorder (sex interaction)
14,154 European ancestry male cases, 17,948 European ancestry male controls, 4,945 European ancestry female cases, 16,246 European ancestry female controls
Sex difference in attention deficit hyperactivity disorder
14,154 European ancestry male cases, 4,945 European ancestry female cases
280 Han Chinese ancestry cases, 350 Han Chinese ancestry controls
9,764 Han Chinese ancestry cases, 11,434 Han Chinese ancestry controls
Theory of mind score in adolescence (Emotional Triangles Task)
4,577 European ancestry adolescents
Open-angle glaucoma and optic cup area
3,071 European ancestry open-angle glaucoma cases, 6,750 European ancestry controls, 22,489 European ancestry individuals with optic disc data, 7,339 Asian ancestry individuals with optic disc data
Open-angle glaucoma and optic disc area
3,071 European ancestry open-angle glaucoma cases, 6,750 European ancestry controls, 22,504 European ancestry individuals with disc area data, 7,307 Asian ancestry individuals with disc area data
Open-angle glaucoma and vertical cup-disc ratio
3,071 European ancestry open-angle glaucoma cases, 6,750 European ancestry controls, 23,899 European ancestry individuals with vertical cup to disc ratio data, 8,373 Asian ancestry individuals with vertical cup to disc ratio data
Open-angle glaucoma and intra-ocular pressure
3,071 European ancestry open-angle glaucoma cases, 6,750 European ancestry controls, 29,578 European ancestry individuals with intraocular pressure data, 8,352 Asian ancestry individuals with intraocular pressure data
3,071 European ancestry cases, 6,750 European ancestry controls
3,853 cases, 33,480 controls
Attention deficit hyperactivity disorder or educational attainment (years of education) (pleiotropy)
2,064 European and unknown ancestry ADHD trios, 896 European and unknown ancestry ADHD cases, 2,455 European and unknown ancestry controls, 328,917 European ancestry individuals with educational attainment data
Sperm motility
811 Japanese ancestry males
779 Japanese ancestry males
Survival in breast cancer (TP53 expression interaction)
572 Finnish ancestry cases
4,610 European ancestry cases
Survival in TP53 positive breast cancer
157 Finnish ancestry cases
Serum galactose-deficient IgA1 levels
950 Han Chinese ancestry individuals, 245 European ancestry individuals
653 East Asian ancestry individuals, 785 European ancestry individuals
411 Italian ancestry cases
8,720 European ancestry cases, 55,152 European ancestry controls
6,489 European ancestry cases, 62,797 European ancestry controls, 1,499 African American cases, 9,145 African American controls, 1,056 Hispanic cases, 2,403 Hispanic controls
Affymetrix, Illumina [at least 2305318] (imputed)
217 Korean ancestry cases, 217 Korean ancestry controls
Trans-epidermal water loss
611 Han Chinese ancestry individuals
366 Han Chinese ancestry individuals
Post traumatic stress disorder symptom count in trauma-exposed individuals
254 Mexican American individuals, 258 American Indian individuals
12,469 European ancestry cases, 18,190 European ancestry controls.
5,819 European ancestry cases, 18,190 European ancestry controls.
6,191 European ancestry cases, 18,190 European ancestry controls.
Very low density lipoprotein cholesterol levels
Waist circumference adjusted for body mass index
Waist-to-hip ratio adjusted for body mass index
Homeostasis model assessment of insulin resistance adjusted for BMI
Rheumatoid arthritis (ACPA-positive)
2,234 Korean ancestry cases, 7,065 Korean ancestry controls, 10,288 European ancestry cases, 35,502 European ancestry controls
Genome-wide genotyping array, Targeted genotyping array [ImmunoChip]
1,045 Thai ancestry individuals
Alcohol consumption (max-drinks)
Response to alcohol consumption (flushing response)
537 Thai ancestry individuals with flushing response, 508 Thai ancestry individuals without flushing response
3,980 Japanese ancestry cases, 18,815 Japanese ancestry controls
4,406 East Asian ancestry cases, 18,161 East Asian ancestry controls, 5,008 European ancestry cases, 35,472 European ancestry controls, 769 African American cases, 663 African American controls, 1,572 Sub-Saharan African ancestry cases, 1,374 Sub-Saharan African ancestry controls.
Pediatric areal bone mineral density (radius)
488 European ancestry female children, 445 European ancestry male children
245 European ancestry female children, 241 European ancestry male children
Pediatric bone mineral density (spine)
Pediatric bone mineral content (femoral neck)
Pediatric bone mineral density (femoral neck)
Pediatric bone mineral density (hip)
Pediatric bone mineral content (radius)
Pediatric bone mineral content (spine)
Pediatric bone mineral content (hip)
Alcohol misuse (trauma interaction)
1,748 African American trauma-exposed individuals, 643 African American trauma-unexposed individuals, 10,732 European ancestry trauma-exposed and unexposed individuals, 3,238 Hispanic trauma-exposed and unexposed individuals
2,738 African American trauma-exposed individuals, 1,591 African American trauma-unexposed individuals, 3,755 European ancestry trauma-exposed and unexposed individuals
Complex regional pain syndrome
115 cases, 115 controls
243 German ancestry cases and 1285 German ancestry controls
294 cases and 272 controls
Low-grade serous and serous borderline ovarian cancer
2,966 European ancestry cases, 40,941 European ancestry controls
Ovarian cancer in BRCA2 mutation carriers
954 European ancestry carrier cases, 11,458 European ancestry carrier controls
16,924 European ancestry cases, 68,502 European ancestry controls
Ovarian clear cell cancer
1,366 European ancestry cases, 40,941 European ancestry controls
Endometrioid ovarian cancer
2,810 European ancestry cases, 40,941 European ancestry controls
Mucinous ovarian carcinoma
2,566 European ancestry cases, 40,941 European ancestry controls
Serous invasive ovarian cancer
14,049 European ancestry cases, 40,941 European ancestry controls
Serous borderline ovarian cancer
1,954 European ancestry cases, 40,941 European ancestry controls
13,037 European ancestry cases, 40,941 European ancestry controls
Low-grade serous ovarian cancer
1,012 European ancestry cases, 40,941 European ancestry controls
Ovarian cancer in BRCA1 mutation carriers
2,933 European ancestry carrier cases, 16,103 European ancestry carrier controls
Invasive epithelial ovarian cancer
22,406 European ancestry cases, 40,941 European ancestry controls
Interleukin-12p70 levels
8,270 Finnish ancestry individuals
Interleukin-16 levels
3,483 Finnish ancestry individuals
8,293 Finnish ancestry individuals
843 Finnish ancestry individuals
Macrophage colony stimulating factor levels
840 Finnish ancestry individuals
Monokine induced by gamma interferon levels
Macrophage inflammatory protein 1a levels
3,522 Finnish ancestry individuals
Macrophage inflammatory protein 1b levels
8,243 Finnish ancestry individuals
Platelet-derived growth factor BB levels
RANTES levels
3,421 Finnish ancestry individuals
8,290 Finnish ancestry individuals
Stem cell growth factor beta levels
3,682 Finnish ancestry individuals
Stromal-cell-derived factor 1 alpha levels
5,998 Finnish ancestry individuals
3,454 Finnish ancestry individuals
1,559 Finnish ancestry individuals
TRAIL levels
8,186 Finnish ancestry individuals
Sjögren's syndrome
460 Asian ancestry cases, 1125 Asian ancestry controls
585 European ancestry cases, up to 51 African ancestry cases, up to 164 Hispanic/Native american cases, up to 570 Asian ancestry cases, up to 59 cases, 3,546 European ancestry controls, 495 African ancestry controls, 237 Hispanic/Native American controls, 306 Asian ancestry controls, 148 controls.
Multiple system atrophy (pathologically confirmed)
295 European ancestry cases, 3,864 European ancestry controls
Multiple system atrophy
918 European ancestry cases, 3,864 European ancestry controls
Pursuit maintenance gain in psychotic disorders
114 African ancestry schizophrenia cases, 69 African schizo-affective cases, 41 African ancestry bipolar disorder cases, 116 European ancestry schizophrenia cases, 86 European ancestry schizo-affective cases, 165 European ancestry bipolar disorder cases
Initial pursuit acceleration
114 African ancestry schizophrenia cases, 69 African schizo-affective cases, 41 African ancestry bipolar disorder cases, 76 African ancestry controls, 116 European ancestry schizophrenia cases, 86 European ancestry schizo-affective cases, 165 European ancestry bipolar disorder cases, 182 European ancestry controls
Pursuit maintenance gain
Initial pursuit acceleration in psychotic disorders
Anti-saccade error rate in psychotic disorders
7,297 European ancestry cases, 5,577 European ancestry controls, 918 European ancestry whole genome sequenced cases, 921 European ancestry whole genome sequenced controls, African American cases, 1,500 African American controls
Obstructive sleep apnea trait (apnea hypopnea index)
677 African American women, 544 African American men, 115 Asian women, 113 Asian men, 1,825 European ancestry women, 3,902 European ancestry men, 7,492 Hispanic women, 5,065 Hispanic men
Obstructive sleep apnea during non-REM sleep (apnea hypopnea index)
1,221 African American individuals, 228 Asian individuals, 5,727 European ancestry individuals,12,557 Hispanic individuals
206 African American individuals, 2,792 Asian individuals, 5,315 European ancestry individuals, 55 European ancestry obstructive sleep apnea cases, 12 European ancestry controls
Obstructive sleep apnea during REM sleep (apnea hypopnea index)
Facial emotion recognition
4,097 European ancestry individuals
Facial emotion recognition (happy faces)
Facial emotion recognition (sad faces)
Facial emotion recognition (angry faces)
Facial emotion recognition (fearful faces)
Smoking status (daily vs non-daily)
778 Hispanic non-daily smoker cases, 1,786 Hispanic daily smoker controls
85 Hispanic non-daily smokers, 343 Hispanic daily smokers, 158 African American non-daily smokers, 1,106 African American daily smokers, 232 European ancestry non-daily smokers, 1,316 European ancestry daily smokers
Smoking status (heavy vs light)
1,929 Hispanic heavy smoker cases, 3,156 Hispanic light smoker controls
Smoking status (current vs former)
2,564 Hispanic current smoker cases, 2,555 Hispanic former smoker controls
5,119 Hispanic ever smoker cases, 7,616 Hispanic never smoker controls
Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel
147 European ancestry women
Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin
289 European ancestry women
Tooth agenesis
1,944 Icelandic ancestry cases, 338,554 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
151 European ancestry cases, 6,019 European ancestry controls, 150 European and other ancestry cases, 2,696 European and other ancestry controls
Tooth agenesis (mandibular second premolars)
1,196 Icelandic ancestry cases, 338,554 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
66 European ancestry cases, 4,667 European ancestry controls, 82 European and other ancestry cases, 2,696 European and other ancestry controls
Tooth agenesis (maxillary lateral incisors)
600 Icelandic ancestry cases, 338,554 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
102 European ancestry cases, 204 European ancestry controls, 32 European and other ancestry cases, 2,696 European and other ancestry controls
Tooth agenesis (maxillary second premolars)
Vaso-occlusive pain in sickle-cell anemia
359 African ancestry individuals, 934 African ancestry children
19,693 European ancestry cases, 107,308 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ancestry controls
Affymetrix, Illumina [1918233] (imputed)
up to 12,931 European ancestry cases, up to 57,196 European ancestry controls
Affymetrix, Illumina [~ 13000000] (imputed)
7,522 European ancestry cases, 50,446 European ancestry controls
35,789 African-American, East Asian, South Asian, European or Hispanic cases, 56,738 African-American, East Asian, South Asian, European or Hispanic controls
5,277 European ancestry cases, 15,702 European ancestry controls
9,253 European ancestry cases and controls, 3,490 Hispanic case and controls, 174,532 cases and controls
Affymetrix, Illumina [~ 1000000] (imputed)
Nodular sclerosis Hodgkin lymphoma
1,278 European ancestry cases, 14,325 European ancestry controls
1,586 cases, 3,069 controls
Mixed cellularity Hodgkin lymphoma
828 European ancestry cases, 14,315 European ancestry controls
135 cases, 3,069 controls
3,077 European ancestry cases, 13,680 European ancestry controls
2,237 cases, 3,069 controls
Body mass index x sex interaction
up to 142,613 European ancestry men, up to 167,276 European ancestry women
Affymetrix, Illumina, Perlegen [up to 2800000] (imputed)
Genome-wide genotyping array, Targeted genotyping array [Metabochip, CardioMetabochip]
Body mass index x sex x age interaction (4df test)
up to 51,625 European ancestry men aged <50, up to 60,654 European ancestry women aged <50, up to 90,988 European ancestry men aged >50, up to 106,622 European ancestry women aged >50
up to 309,889 European ancestry individuals
Body mass index (age>50)
up to 90,988 European ancestry men, up to 106,622 European ancestry women
Body mass index (age <50)
up to 51,625 European ancestry men, up to 60,654 European ancestry women
Body mass index x age interaction
up to 112,279 European ancestry individuals aged <50, up to 197,610 European ancestry individuals aged >50
Body mass index x sex x age interaction
up to 113,720 European ancestry men, up to 138,655 European ancestry women
Waist-to-hip ratio adjusted for BMI (age <50)
up to 43,776 European ancestry men, up to 50,526 European ancestry women
Waist-to-hip ratio adjusted for BMI (age >50)
up to 69,944 European ancestry men, up to 88,129 European ancestry women
Waist-to-hip ratio adjusted for BMI x sex interaction
Waist-to-hip ratio adjusted for BMI x sex x age interaction
up to 43,776 European ancestry men aged <50, up to 50,526 European ancestry women aged <50, up to 69,944 European ancestry men aged >50, up to 88,129 European ancestry women aged >50
Waist-to-hip ratio adjusted for BMI x age interaction
up to 94,302 European ancestry individuals aged <50, up to 158,073 European ancestry individuals aged >50
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)
14,135 European ancestry cases, 58,126 European ancestry controls
7,333 European ancestry cases, 42,468 European ancestry controls
14,135 European ancestry ER- cases, 58,126 European ancestry controls, 7,784 European ancestry BRCA1 carrrier cases, 7,782 European ancestry BRCA1 carrrier controls
7,333 European ancestry ER- cases, 42,468 European ancestry controls, 1,630 European ancestry BRCA1 carrrier cases, 1,712 European ancestry BRCA1 carrrier controls
Breast Cancer in BRCA1 mutation carriers
7,784 European ancestry carrier cases, 7,782 European ancestry carrier controls
1,630 European ancestry carrier cases, 1,712 European ancestry carrier controls
Problematic alcohol use in trauma-exposed individuals
1,036 African American individuals
828 European ancestry individuals, 108 African ancestry individuals, 282 Hispanic and Native American individuals, 170 other ancestry individuals, 6 Asian individuals
Paclitaxel disposition in epithelial ovarian cancer
66 European ancestry cases, 14 Asian ancestry cases
Carboplatin disposition in epthelial ovarian cancer
42 European ancestry cases, 14 Asian ancestry cases
Severe malaria (adjusted for sickle cell variant rs334)
449 Tanzanian ancestry cases, 465 Tanzanian ancestry controls
Severe malaria
2,152 Chinese ancestry cases, 3,740 Chinese ancestry controls
4,716 Chinese ancestry cases, 5,379 Chinese ancestry controls
Illumina [Sequenom custom array used in replication] (imputed)
Smoking interaction in non-small cell lung cancer (1df test)
1,399 European ancestry never smoker cases, 11,937 European ancestry smoker cases
Smoking interaction in lung adenocarcinoma (1df test)
1,097 European ancestry never smoker cases, 5,918 European ancestry smoker cases
Smoking interaction in squamous cell lung cancer (1df test)
159 European ancestry never smoker cases, 4,370 European ancestry smoker cases
Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic)
123 European ancestry cases, 191 European ancestry controls
85 European ancestry cases, 136 European ancestry controls, 81 Hispanic cases, 112 Hispanic controls
Systolic blood pressure in combination therapy (beta blocker and thiazide diuretic)
314 European ancestry individuals
221 European ancestry individuals, 193 Hispanic individuals
Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic)
775 Chinese ancestry individuals
Systolic blood pressure x sodium interaction (2df test)
Diastolic blood pressure x sodium interaction (2df test)
Mean arterial pressure x sodium interaction (2df test)
Mean arterial pressure x sodium interaction (1df test)
Pulse pressure x sodium interaction (1df test)
Pulse pressure x sodium interaction (2df test)
8,393 European ancestry individuals
1,023 African American individuals, 491 Hispanic individuals
Affymetrix, Illumina [~ 7400000] (imputed)
Affymetrix, Illumina [8307659] (imputed)
Pulse pressure (dietary potassium intake interaction)
Systolic blood pressure (dietary potassium intake interaction)
Diastolic blood pressure (dietary potassium intake interaction)
Mean arterial pressure (dietary potassium intake interaction)
978 Austrian ancestry colorectal cancer cases, 636 Austrian ancestry advanced colorectal adenoma cases, , 855 Austrian ancestry controls
978 Austrian ancestry cases, 4,294 European ancestry controls
978 Austrian ancestry colorectal cancer cases, 636 Austrian ancestry advanced colorectal adenoma cases, 4,294 European ancestry controls
636 Austrian ancestry cases, 4,294 European ancestry controls
978 Austrian ancestry cases, 855 Austrian ancestry controls
636 Austrian ancestry cases, 855 Austrian ancestry controls
Colonoscopy-negative controls vs population controls
855 Austrian ancestry colonoscopy-negative controls, 3,439 European ancestry controls
395 European ancestry cases, 1,975 European ancestry controls
1,243 European ancestry cases, 4,779 European ancestry controls
1,158 European ancestry cases, 3,071 European ancestry controls
1,541 European ancestry cases, 2,634 European ancestry controls
Neuroblastoma (11q deletion)
113 European ancestry cases, 5,109 European ancestry controls
44 European ancestry cases, 1,902 European ancestry controls
Neuroblastoma (11q deletion vs 11q undeleted and MYCN amplification)
113 European ancestry 11q-deletion neuroblastoma cases, 78 European ancestry 11q-undeleted neuroblastoma cases, 204 European ancestry MYCN-amplification neuroblastoma cases
Neuroblastoma (1p deletion)
69 European ancestry cases, 5,109 European ancestry controls
Neuroblastoma (MYCN amplification)
260 European ancestry cases, 5,109 European ancestry controls
Pediatric non-alcoholic fatty liver disease activity score
208 Hispanic boys
Liver fibrosis in pediatric non-alcoholic fatty acid liver disease
Pediatric nonalcoholic steatohepatitis
46 Hispanic boy definite NASH cases, 110 Hispanic boy borderline NASH controls
Femoral neck bone geometry
411 Mexican ancestry women
420 Mexican ancestry women
Hepatocellular carcinoma in hepatitis C infection
502 Chinese ancestry cases, 749 Chinese ancestry controls
669 Chinese ancestry cases, 429 Chinese ancestry controls
Amyotrophic lateral sclerosis (sporadic)
1,234 Chinese ancestry cases, 2,850 Chinese ancestry controls, 12,577 European ancestry cases, 23,475 European ancestry controls
576 cases, 683 controls
59,088 European ancestry females, 53,029 European ancestry males
Alcohol consumption in current drinkers
108,309 European ancestry individuals
742 African American cases, 475 African American controls
Caudate activity during disappointment
106 individuals
Caudate activity during reward
Putamen activity during reward
Putamen actvity during disappointment
113 European ancestry Alzheimer's disease cases, 207 European ancestry individuals with late mild cognitive impairment, 239 European ancestry individuals with early mild cognitive impairment, 85 European ancestry individuals with significant memory concern, 199 European ancestry controls.
Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms
13,781 European ancestry individuals
Affymetrix, Illumina [at least 7600000] (imputed)
Atopy
925 European ancestry cases, 735 European ancestry controls
641 French Canadian (founder/population isolate) cases, 497 French Canadian (founder/population isolate) controls, 106 cases, 340 controls
IgG sialylation phenotypes (multivariate analysis)
1,960 Orcadian (founder/genetic isolate) individuals
IgG disialylation phenotypes (multivariate analysis)
IgG monosialylation phenotypes (multivariate analysis)
IgG fucosylation phenotypes (multivariate analysis)
IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis)
IgG galactosylation phenotypes (multivariate analysis)
IgG monogalactosylation phenotypes (multivariate analysis)
IgG digalactosylation phenotypes (multivariate analysis)
3,558 European ancestry cases, 13,970 European ancestry controls
Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous)
244 cases, 225 controls
Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous)
13,184 Hispanic/Latino individuals
7,073 European ancestry individuals, 4,771 African American individuals
Affymetrix, Illumina [16967914] (imputed)
Heart rate variability traits (RMSSD)
13,767 Hispanic/Latino individuals
4,730 European ancestry individuals, 2,908 African American individuals
Affymetrix, Illumina [17209892] (imputed)
Heart rate variability traits (SDNN)
7,073 European ancestry individuals, 2,908 African American individuals
Affymetrix, Illumina [17209740] (imputed)
354,862 European ancestry individuals
Subjective well-being (MTAG)
388,538 European ancestry individuals
Neuroticism (MTAG)
168,105 European ancestry individuals
Subjective well-being
Cerebral blood flow
4,472 Dutch individuals
1,350 Icelandic individuals
27,850 European ancestry individuals
24,125 European ancestry individuals, 11,234 Hispanic/Latino individuals, 6,899 African American individuals
Affymetrix, Illumina, Perlegen [at least 2135543] (imputed)
26,523 European ancestry individuals
20,429 European ancestry individuals, 11,234 Hispanic/Latino individuals, 6,895 African American individuals
Heart rate variability traits (pvRSA/HF)
24,088 European ancestry individuals
9,377 European ancestry individuals, 404 Hispanic/Latino individuals, 1,901 African American individuals
Insomnia complaints
12,863 European ancestry male cases, 19,521 European ancestry female cases, 40,776 European ancestry male controls, 39,846 European ancestry female controls
1,983 Icelandic ancestry male cases, 1,791 Icelandic ancestry female cases, 2,064 Icelandic ancestry male controls, 1,727 Icelandic ancestry female controls
Affymetrix [at least 12428592] (imputed)
112,411 European ancestry male individuals
Insomnia complaints (sex interaction)
Insomnia complaints (continuous)
Insomnia complaints (dichotomous)
32,384 European ancestry cases, 27,128 European ancestry controls
101,185 European ancestry individuals
112,866 European ancestry individuals
113,054 European ancestry cases and controls
105,377 European ancestry cases and controls
112,717 European ancestry cases and controls
19,521 European ancestry female cases, 39,846 European ancestry female controls
12,863 European ancestry male cases, 40,776 European ancestry male controls
5,075 Bangladeshi ancestry individuals
Craniofacial microsomia
330 Chinese ancestry left-side-affected cases, 609 Chinese ancestry right-side-affected cases, 2,012 Chinese ancestry controls
151 Chinese ancestry left-side-affected cases, 292 Chinese ancestry right-side-affected cases, 1,669 Chinese ancestry controls
Rate of cognitive decline in mild cognitive impairment (time interaction)
822 European ancestry individuals
2,861 British and Irish ancestry cases, 8,514 British and Irish ancestry controls
White matter microstructure in first episode schizophrenia (right posterior cingulate cortex)
93 Han Chinese cases, 134 Han Chinese controls
Total mean fractional anisotropy measurement in first episode schizophrenia
White matter microstructure in first episode schizophrenia (left posterior cingulate cortex)
White matter microstructure in first episode schizophrenia (left inferior parietal cortex)
Abnormal white matter microstructure in first episode schizophrenia (multivariate analysis)
White matter microstructure in first episode schizophrenia (left anterior cingulate cortex)
White matter microstructure in first episode schizophrenia (right anterior cingulate cortex)
Up to 16,144 European ancestry cases, up to 17,832 European ancestry controls
Age-related macular degeneration (SNP x mitochondrial T5004C interaction)
15,407 European ancestry cases, 16,350 European ancestry controls
Age-related macular degeneration (SNP x mitochondrial A4917G interaction)
16,122 European ancestry cases, 17,810 European ancestry controls
Age-related macular degeneration (SNP x mitochondrial G12771A interaction)
15,413 European ancestry cases, 16,351 European ancestry controls
Age-related macular degeneration (SNP x mitochondrial C16069T interaction)
16,042 European ancestry cases, 17,734 European ancestry controls
15,979 European ancestry cases, 102,776 European ancestry controls, 641 African American cases, 5,234 African American controls, 837 Japanese ancestry cases, 3,293 Japanese controls, 277 Hispanic cases, 3,081 Hispanic controls,197 Brazilian ancestry cases, 758 Brazilian ancestry controls.
8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls.
Affymetrix, Illumina [11795432] (imputed)
3,666 cases, 139,852 controls
15,979 European ancestry cases, 102,776 European ancestry controls.
837 Japanese ancestry cases, 3,293 Japanese controls
641 African American cases, 5,234 African American controls
447 African American cases, 442 African American controls
Incident atrial fibrillation
7,323 European ancestry cases, 102,776 European ancestry controls.
Affymetrix, Illumina [at least 3187278] (imputed)
Prevalent atrial fibrillation
8,656 European ancestry cases, 102,776 European ancestry controls.
Glomerular filtration rate (cystatin C)
24,063 European ancestry individuals
Affymetrix, Illumina [up to 10971307] (imputed)
Glomerular filtration rate (creatinine)
110,517 European ancestry individuals
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular)
2,816 European ancestry cases, 13,056 European ancestry controls
Fear of severe pain
Up to 1,367 European ancestry individuals, up to 159 African American individuals, up to 13 Hispanic individuals, up to 23 Asian, Native American and other ancestry individuals, up to 21 individuals
Fear of minor pain
Fear of medical pain (dental)
Fear of pain
Verbal memory performance (delayed recall level)
7,486 European ancestry individuals aged 50 years or older
Verbal memory performance (residualized delayed recall change)
6,898 European ancestry individuals aged 50 years or older
Verbal memory performance (immediate recall change)
Verbal memory performance (residualized delayed recall level)
Verbal memory performance (immediate recall level)
Verbal memory performance (delayed recall change)
Borderline personality disorder
998 European ancestry cases, 1,545 European ancestry controls
4,739 European ancestry individuals
1,301 European ancestry individuals, 2 South African individuals
Estrone conjugates/estrone ratio in resected early stage estrogen-receptor positive breast cancer
707 European ancestry postmenopausal cases, 52 African ancestry postmenopausal cases, 15 Asian ancestry postmenopausal cases
Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer
Plasma estrone levels in resected estrogen-receptor positive breast cancer
Plasma androstenedione levels in resected early stage-receptor positive breast cancer
Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer
Mean corpuscular hemoglobin concentration in sickle cell disease
317 cases
Red blood cell density in sickle cell anemia
374 cases
Activities of daily living score
286 Sirente (founder/genetic isolate) elderly individuals
Short physical performance battery score
Mid-arm muscle circumference
Four meter walk test score
1,055 European ancestry elderly individuals
Cognitive performance
Calf circumference
Anorexia nervosa (excluding migration to or from binge-eating disorder or bulimia nervosa)
692 European ancestry female cases and 3,570 European ancestry female controls
Cases and controls (see Boraska et al, 2014)
Neurocognitive impairment in HIV-1 infection (continuous)
490 African American individuals, 443 European ancestry individuals, 99 Hispanic individuals, 17 individuals
HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment)
155 African American asymptomatic neurocognitive impairment cases, 150 European ancestry asymptomatic neurocognitive impairment cases, 49 Hispanic asymptomatic neurocognitive impairment cases, 5 asymptomatic neurocognitive impairment cases, 30 African American mild neurocognitive disorder cases, 45 European ancestry mild neurocognitive disorder cases, 17 Hispanic mild neurocognitive disorder cases, 297 African American controls, 230 European ancestry controls, 29 Hispanic controls, 11 controls
HIV-associated neurocognitive disorder (mild neurocognitive disorder)
30 African American cases, 45 European ancestry cases, 17 Hispanic cases, 297 African American controls, 230 European ancestry controls, 29 Hispanic controls, 11 controls
HIV-associated neurocognitive disorder
192 African American cases, 213 European ancestry cases, 70 Hispanic cases, 6 unknown ancestry cases, 297 African American controls, 230 European ancestry controls, 29 Hispanic controls, 11 controls
Neurocognitive impairment in HIV-1 infection (dichotomous)
140 African American cases, 167 European ancestry cases, 53 Hispanic cases, 6 cases, 350 African American controls, 276 European ancestry controls, 46 Hispanic controls, 11 controls
HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment)
155 African American cases, 150 European ancestry cases, 49 Hispanic cases, 5 cases, 297 African American controls, 230 European ancestry controls, 29 Hispanic controls, 11 controls
Motor development (prenatal lead exposure interaction)
390 Mexican children, 490 Bangladeshi children
Mental development (prenatal lead exposure interaction)
BMI (smoking interaction)
98,173 European ancestry women, 64,373 European ancestry men, 5,829 European ancestry individuals, 10,500 African American/Afro-Caribbean ancestry women, 2,706 African American/Afro-Caribbean ancestry men, 1,030 Indian Asian ancestry women, 7,648 Indian Asian ancestry men, 1,793 Filipino ancestry women, 2,944 Hispanic/Latino ancestry women, 1,764 Hispanic/Latino ancestry men
21,496 European ancestry women, 24,385 European ancestry men, 118,364 European ancestry individuals, 2,326 African American/Afro-Caribbean ancestry women, 855 African American/Afro-Caribbean ancestry men
Waist circumference adjusted for BMI (adjusted for smoking behaviour)
97,400 European ancestry women, 63,892 European ancestry men, 5,829 European ancestry individuals, 10,500 African American/Afro-Caribbean ancestry women, 2,706 African American/Afro-Caribbean ancestry men, 1,030 Indian Asian ancestry women, 7,648 Indian Asian ancestry men, 1,793 Filipino ancestry women, 2,944 Hispanic/Latino ancestry women, 1,764 Hispanic/Latino ancestry men
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour)
95,362 European ancestry women, 62,085 European ancestry men, 5,829 European ancestry individuals, 10,500 African American/Afro-Caribbean ancestry women, 2,706 African American/Afro-Caribbean ancestry men, 1,030 Indian Asian ancestry women, 7,648 Indian Asian ancestry men, 1,793 Filipino ancestry women, 2,944 Hispanic/Latino ancestry women, 1,764 Hispanic/Latino ancestry men
Waist circumference adjusted for BMI (smoking interaction)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)
Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction)
BMI (adjusted for smoking behaviour)
Waist-to-hip ratio adjusted for BMI in smokers
18,972 European ancestry women, 16,109 European ancestry men, 973 European ancestry individuals, 1,701 African American/Afro-Caribbean ancestry women, 903 African American/Afro-Caribbean ancestry men, 10 Indian Asian ancestry women, 957 Indian Asian ancestry men, 267 Filipino ancestry women, 475 Hispanic/Latino ancestry women, 446 Hispanic/Latino ancestry men
5,485 European ancestry women, 6,471 European ancestry men, 13,416 European ancestry individuals, 253 African American/Afro-Caribbean ancestry women, 208 African American/Afro-Caribbean ancestry men
Waist-to-hip ratio adjusted for BMI in non-smokers
75,379 European ancestry women, 45,811 European ancestry men, 4,856 European ancestry individuals, 8,799 African American/Afro-Caribbean ancestry women, 1,803 African American/Afro-Caribbean ancestry men, 1,020 Indian Asian ancestry women, 6,691 Indian Asian ancestry men, 1,526 Filipino ancestry women, 2,469 Hispanic/Latino ancestry women, 1,318 Hispanic/Latino ancestry men
16,011 European ancestry women, 17,912 European ancestry men, 105,218 European ancestry individuals, 2,073 African American/Afro-Caribbean ancestry women, 647 African American/Afro-Caribbean ancestry men
1,783 Northern European ancestry cases, 7,435 Northern European ancestry controls
up to 1,490 European ancestry cases, up to 1,723 European ancestry controls
2,364 Northern European ancestry cases, 7,435 Northern European ancestry controls
1,783 Northern European ancestry glioblastoma cases, 2,364 Northern European ancestry non-glioblastoma cases, 7,435 Northern European ancestry controls
1,490 European ancestry cases, 1,723 European ancestry control
C-reactive protein levels in ischemic stroke
up to 1,725 European ancestry cases, up to 258 African ancestry cases, up to 117 cases
Thrombomodulin levels in ischemic stroke
Creatinine levels in ischemic stroke
1,725 European ancestry cases, 258 African ancestry cases, 117 cases
Thrombin-antithrombin complex levels in ischemic stroke
Fibrinogen levels in ischemic stroke
Prothrombin fragments F1+2 levels in ischemic stroke
up to 1,725 European ancestry cases,up to 258 African ancestry cases, up to 117 cases
Cutaneous psoriasis
1,363 European ancestry cases, 4,934 European ancestry controls
up to 2,969 European ancestry cases, up to European ancestry 14,384 controls
Psoriasis vulgaris
4,007 European ancestry cases, 4,934 European ancestry controls
up to 9,075 European ancestry cases, up to European ancestry 12,726 controls
Psoriatic arthritis
1,946 European ancestry cases, 4,934 European ancestry controls
up to 2,883 European ancestry cases, up to 14,179 European ancestry controls
Psoriatic arthritis vs Cutaneous psoriasis
1,946 European ancestry psoriatic arthritis cases, 1,363 European ancestry cuteneous psoriasis cases
up to 3,216 European ancestry psoriatic arthritis cases, up to 2,968 European ancestry cuteneous psoriasis cases
275 Korean ancestry cases, 2,369 Korean ancestry controls
242 Korean ancestry cases, 1,066 Korean ancestry controls
Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid)
717 Singaporean Chinese ancestry myocardial infarction cases, 644 Singaporean Chinese ancestry controls
Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid)
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid)
Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid)
Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)
Delta-5 desaturase activity
Delta-6 desaturase activity
Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid)
146 African American cases, 432 African American controls
94 African American cases, 65 African American controls
Nickel levels
949 European ancestry individuals
Chromium levels
Cobalt levels
Aluminium levels
Manganese levels
Molybdenum levels
Lead levels
Zinc levels
Mercury levels
Cadmium levels
Copper levels
up to 14,094 European ancestry men, up to 19,893 European ancestry women
up to 9,076 European ancestry men, up to 9,150 European ancestry women
14,586 European ancestry men, 20,706 European ancestry women
8,554 European ancestry men, 8,337 European ancestry women
6,877 East Asian ancestry never smoker cases, 6,277 East Asian ancestry never smoker controls
5,878 East Asian ancestry never smoker cases, 7,046 East Asian ancestry never smoker controls
Affymetrix, Illumina [7564751] (imputed)
Adenocarcinoma
Up to 5,744 Chinese ancestry cases, up to 4,817 Chinese ancestry controls, up to 1,133 Japanese ancestry cases, up to 1,460 Japanese ancestry controls
Up to 4,647 Chinese ancestry cases, up to 4,099 Chinese ancestry controls, up to 1,231 Japanese ancestry cases, up to 2,947 Japanese ancestry controls
Gut microbiome composition (summer)
91 Hutterite individuals
Gut microbiome composition (summer and winter)
127 Hutterite individuals
Gut microbiome composition (winter)
93 Hutterite individuals
Alzheimer's disease or small vessel stroke
17,008 European ancestry Alzheimer's disease cases, 3,651 European ancestry small vessel stroke cases, 95,811 European ancestry controls
1,109 Indo-European ancestry individuals
3,725 Indo-European ancestry individuals
up to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals
up to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828 Filipino female individuals, 205 Seychellois male individuals, 287 Seychellois female individuals, 2,964 South Asian ancestry male individuals, 658 South Asian ancestry female individuals
Squamous cell carcinoma
745 European ancestry cases, 12,805 European ancestry controls
531 European ancestry cases, 551 European ancestry controls
2,178 Han Chinese ancestry centenarian cases, 2,299 Han Chinese ancestry middle-age controls
40 Korean ancestry low BMI individuals, 37 Korean ancestry high BMI individuals
Basal metabolic rate
39 Korean ancestry low BMR individuals, 38 Korean ancestry high BMR individuals
15,117 European ancestry individuals, 2,131 Erasmus Rucphen Family individuals
2,405 Chinese ancestry individuals, 2,305 Malay ancestry individuals, 2,131 Indian ancestry individuals
15,087 European ancestry individuals, 2,131 Erasmus Rucphen Family individuals, 2,363 Chinese ancestry individuals, 2,225 Malay ancestry individuals, 2,025 Indian ancestry individuals
Affymetrix, Illumina [2500000] (imputed)
15,087 European ancestry individuals, 2,131 Erasmus Rucphen Family individuals
2,363 Chinese ancestry individuals, 2,225 Malay ancestry individuals, 2,025 Indian ancestry individuals
15,117 European ancestry individuals, 2,131 Erasmus Rucphen Family individuals, 2,405 Chinese ancestry individuals, 2,305 Malay ancestry individuals, 2,131 Indian ancestry individuals
1,548 Chinese ancestry cases, 2,150 Chinese ancestry controls, 4,362 Chinese ancestry controls with immune-related diseases
6,765 Chinese ancestry cases, 9,505 Chinese ancestry controls
Trans fatty acid levels
8,013 European ancestry individuals
1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
up to 20,132 European ancestry individuals
10,092 European and East Asian ancestry individuals
up to 20,162 European ancestry individuals
10,037 European and East Asian ancestry individuals
3,953 European ancestry individuals
Entorhinal cortical thickness
424 European ancestry mild cognitive impairment cases, 236 European ancestry Alzheimer's disease cases, 279 European ancestry controls
Entorhinal cortical volume
Whole-brain volume
434 European ancestry mild cognitive impairment cases, 245 European ancestry Alzheimer's disease cases, 284 European ancestry controls
Entorhinal cortical thickness (Alzheimer's disease interaction)
Total ventricular volume
Entorhinal cortical volume (Alzheimer's disease interaction)
Total ventricular volume (Alzheimer's disease interaction)
Whole-brain volume (Alzheimer's disease interaction)
Hippocampal volume (Alzheimer's disease interaction)
1,042 Northern European ancestry individuals
5,654 Northern European ancestry individuals
Bone mineral density (femoral neck)
9541 European ancestry individuals, 1,115 Cilento (founder/genetic isolated) individuals, 897 Ogliastran (founder/genetic isolated) individuals, 1,759 Val Borbera (founder/genetic isolated) individuals
2,141 European ancestry individuals, 659 Sorbian (founder/genetic isolated) individuals
Affymetrix, Illumina [6705861] (imputed)
Low high density lipoprotein cholesterol levels
1,747 Saudi Arab ancestry cases, 2,335 Saudi Arab ancestry controls
517 Saudi Arab ancestry cases, 896 Saudi Arab ancestry controls
Scalp hair shape
6,357 Latin American individuals
Beard thickness
2,922 Latin American individuals
Monobrow thickness
Hair greying
Balding
Non-cardia gastric cancer
2,031 Han Chinese ancestry cases, 4,970 Han Chinese ancestry controls
3,564 Han Chinese ancestry cases, 4,637 Han Chinese ancestry controls
Affymetrix, Illumina [6223896] (imputed)
9,534 European ancestry individuals
Thrombosis
6,135 European ancestry cases, 252,827 European ancestry controls
White matter hyperintensity burden
17,936 European ancestry individuals, 1,943 African American ancestry individuals, 795 Hispanic individuals, 204 Chinese ancestry individuals, 201 Malay ancestry individuals
Affymetrix, Illumina [14227402] (imputed)
White matter hyperintensities in ischemic stroke
3,670 European ancestry cases
Affymetrix, Illumina [7567914] (imputed)
NT-proBNP levels in acute coronary syndrome
at least 3,691 European ancestry individuals, up to 29 Asian ancestry individuals, 20 African ancestry individuals
at least 5,404 European ancestry individuals, up to 54 Asian ancestry individuals, 33 African ancestry individuals
Thoracic-to-hip circumference ratio
2,388 Korean ancestry males, 2,600 Korean ancestry females
767 Korean ancestry males, 1,485 Korean ancestry females
16,144 European ancestry cases, 17,832 European ancestry controls
473 Asian ancestry cases, 1,099 Asian ancestry controls, 52 African ancestry cases, 361 African ancestry cases, 254 other non-European ancestry cases, 694 other non-European ancestry controls
Early childhood aggressive behavior
15,668 European ancestry individuals
Affymetrix, Illumina [up to 3856236] (imputed)
Middle childhood and early adolescence aggressive behavior
16,311 European ancestry individuals
Childhood and early adolescence aggressive behavior
18,988 European ancestry individuals
Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia
50 Japanese ancestry cases, 2905 Japanese ancestry controls
1,083 African American individuals
1,427 African American individuals
Body mass index (age interaction)
9,377 children and adolescents
3,918 European ancestry children and adolescents
Vitamin D levels
1,387 Punjabi Sikh ancestry individuals
2,151 Punjabi Sikh ancestry individuals
2,267 European American children
257 European American children, 15,366 European ancestry adults
Calcaneal bone ultrasound measurement (speed of sound)
1,895 Korean ancestry individuals
7,263 Korean ancestry individuals
3,853 European ancestry cases, 33,480 European ancestry controls
2,137 European ancestry cases, 6,699 European ancestry controls, 1,037 Singaporean Chinese ancestry cases, 2,543 Singaporean Chinese ancestry controls
Affymetrix, Illumina [6425680] (imputed)
Glaucoma (low intraocular pressure)
725 European ancestry cases, 11,145 European ancestry controls
363 European ancestry cases
Glaucoma (high intraocular pressure)
1,868 European ancestry cases, 31,497 European ancestry controls
Rapid functional decline in sporadic amyotrophic lateral sclerosis
59 Japanese ancestry cases with rapid functional decline, 110 Japanese ancestry cases with intermediate functional decline, 70 Japanese ancestry cases with sigmoidal functional decline, 215 Japanese ancestry cases with moderate functional decline
Moderate functional decline in sporadic amyotrophic lateral sclerosis
215 Japanese ancestry cases with moderate functional decline, 59 Japanese ancestry cases with rapid functional decline, 110 Japanese ancestry cases with intermediate functional decline, 70 Japanese ancestry cases with sigmoidal functional decline
Inguinal hernia
5,295 European ancestry cases, 67,510 European ancestry controls
9,701 European ancestry cases, 82,743 European ancestry controls
14,300 European ancestry cases, 1,609 African ancestry cases, 942 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls
996 African ancestry cases, 219 East Asian ancestry cases, 17,334 European ancestry cases, 548 Hispanic cases, 2,385 South Asian ancestry cases, 5,811 African ancestry controls, 329 East Asian ancestry controls, 350,928 European ancestry controls, 686 Hispanic controls, 5,193 South Asian ancestry controls
Ischemic stroke (cardioembolic)
up to 3,400 European ancestry cases, up to 208 African ancestry cases, up to 118 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls
98 African ancestry cases, 31 East Asian ancestry cases, 3,436 European ancestry cases, 97 Hispanic cases, 422 South Asian ancestry cases, 2,917 African ancestry controls, 329 East Asian ancestry controls, 274,063 European ancestry controls, 686 Hispanic controls, 5,193 South Asian ancestry controls
Ischemic stroke (large artery atherosclerosis)
up to 2,349 European ancestry cases, up to 220 African ancestry cases, up to 146 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls
33 African ancestry cases, 34 East Asian ancestry cases, 1,787 European ancestry cases, 40 Hispanic ancestry cases, 355 South Asian ancestry cases, 239 African ancestry controls, 329 East Asian ancestry controls, 176,782 European ancestry controls, 686 Hispanic controls, 5,193 South Asian ancestry controls
Ischemic stroke (small artery occlusion)
up to 2,252 European ancestry cases, up to 381 African ancestry cases, up to 552 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls
47 African ancestry cases, 133 East Asian ancestry cases, 1,847 European ancestry cases, 85 Hispanic cases, 314 South Asian ancestry cases, 239 African ancestry controls, 329 East Asian ancestry controls, 217,755 European ancestry controls, 686 Hispanic controls, 5,193 South Asian ancestry stroke controls
Ischemic stroke (undetermined subtype)
up to 8,062 European ancestry cases, up to 1,086 African ancestry cases, up to 362 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls
17 African ancestry cases, 17 East Asian ancestry cases, 3,514 European ancestry cases, 149 Hispanic cases, 239 African ancestry controls, 329 East Asian ancestry controls, 259,291 European ancestry controls, 686 Hispanic controls
Response to anti-TNF therapy in rheumatoid arthritis
31 Japanese ancestry mild cases, 282 Japanese ancestry moderate cases, 131 Japanese ancestry severe cases
Phospholipid levels
up to 42 Moroccan ancestry affected parents, 210 Moroccan ancestry unaffected parents, up to 239 Moroccan ancestry affected offspring and 67 Moroccan ancestry unaffected offspring from 135 families
up to 317 Moroccan ancestry cases, 650 Moroccan ancestry controls
Atrophic age-related macular degeneration
30 Han Chinese ancestry elderly (>95 years old) cases, 47 Han Chinese ancestry elderly (>95 years old) controls
208 Han Chinese ancestry cases, 218 Han Chinese ancestry controls
Sex ratio
4,183 Korean ancestry male individuals, 4,659 Korean ancestry female individuals
935 Korean ancestry individuals
Exploratory eye movement dysfunction in schizophrenia (responsive search score)
128 Han Chinese ancestry cases
Exploratory eye movement dysfunction in schizophrenia (total eye scanning length)
Exploratory eye movement dysfunction in schizophrenia (mean eye scanning length)
Exploratory eye movement dysfunction in schizophrenia (number of eye fixations)
Exploratory eye movement dysfunction in schizophrenia (cognitive search score)
Epstein Barr virus nuclear antigen 1 IgG levels
1,243 parents and up to 2,356 children from 992 families, 1,956 Mexican American individuals
Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis
3,599 individuals, 1,956 Mexican American individuals, 5,545 European ancestry multiple sclerosis cases, 12,153 European ancestry non-multiple sclerosis controls
Cholesterol, total
4,383 Mexican ancestry individuals
7,876 Latin American/Hispanic individuals, European ancestry individuals (Global Lipids Genetics Consortium et al, 2013)
Colorectal cancer (menopausal hormone therapy interaction)
1,436 European ancestry postmenopausal cases, 1,948 European ancestry postmenopausal controls
Colorectal cancer (oestrogen-progestogen hormone therapy interaction)
554 European ancestry postmenopausal cases, 729 European ancestry postmenopausal controls
Colorectal cancer (oestrogen hormone therapy interaction)
650 European ancestry postmenopausal cases, 956 European ancestry postmenopausal controls
Anxiety disorder
up to 7,016 European ancestry cases, up to 14,745 European ancestry controls
Affymetrix, Illumina, Perlegen [~ 6500000] (imputed)
18,186 European ancestry individuals
6,968 European ancestry cases, 20,464 European ancestry controls
10,679 European ancestry cases, 26,715 European ancestry controls, 397 Iranian ancestry cases, 342 Iranian ancestry controls, 1,239 Indian ancestry cases, 990 Indian ancestry controls, 1,134 East Asian ancestry cases, 3,719 East Asian ancestry controls
Affymetrix, Illumina [~ 9000000] (imputed)
5,956 European ancestry cases, 14,927 European ancestry controls
14,594 European ancestry cases, 26,715 European ancestry controls, 151 Iranian ancestry cases, 342 Iranian ancestry controls, 184 Indian ancestry cases, 990 Indian ancestry controls, 1,690 East Asian ancestry cases, 3,719 East Asian ancestry controls
12,882 European ancestry cases, 21,770 European ancestry controls
25,273 European ancestry cases, 26,715 European ancestry controls, 548 Iranian ancestry cases, 342 Iranian ancestry control, 1,423 Indian ancestry cases, 990 Indian ancestry controls, 2,824 East Asian ancestry cases, 3,719 East Asian ancestry controls
up to 44,609 East Asian individuals
up to 25,553 East Asian individuals, up to 230,044 individuals
Affymetrix, Illumina [at least 1850000] (imputed)
up to 39,869 East Asian individuals
up to 20,137 East Asian individuals, up to 209,947 individuals
up to 24,146 East Asian individuals, up to 229,290 individuals
up to 25,553 East Asian individuals, up to 212,173 individuals
Betaine levels in individuals undergoing cardiac evaluation
1,985 individuals
1,895 individuals
up to 883 European and other ancestry individuals
up to 189 European and other ancestry early mild cognitive impairment cases, up to 251 European and other ancestry late mild cognitive impairment cases, up to 121 European and other ancestry Alzheimer's disease cases, up to 215 European and other ancestry healthy controls
up to 3 European and other ancestry significant memory concern cases, up to 57 European and other ancestry early mild cognitive impairment cases, up to 61 European and other ancestry late mild cognitive impairment cases, up to 62 European and other ancestry Alzheimer's disease cases, up to 21 European and other ancestry healthy controls
Cognitive decline rate in late mild cognitive impairment
472 European ancestry cases, 47 cases
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging)
370 European and other ancestry APOEe4 non-carriers
Cerebrospinal T-tau levels
Cerebrospinal P-tau181p levels
up to 189 European and other ancestry early mild cognitive impairment cases, up to 251 European and other ancestry late mild cognitive impairment cases, up to 121 European and other ancestry Alzheimer's disease cases, up to 215 European and other ancestry health
Cerebral amyloid deposition in APOEe4 carriers (PET imaging)
263 European and other ancestry APOEe4 carriers
Cerebral amyloid deposition positivity (PET imaging)
up to 350 European and other ancestry positive individuals, up to 296 European and other ancestry negative individuals
Spherical equivalent (joint analysis main effects and education interaction)
2,604 Erasmus Rucphen population isolate individuals, 456 Sardinian population isolate individuals, 36,976 European ancestry individuals, 5,971 East Asian ancestry individuals, 2,256 Malay ancestry individuals, 2,088 Indian ancestry individuals
Affymetrix, Illumina [up to 7331415] (imputed)
Cannabis dependence symptom count
Up to 6,000 African American ancestry individuals, 8,754 European ancestry individuals
At least 1,893 European ancestry individuals
High fetal hemoglobin in sickle cell disease
up to 376 African American cases, up to 360 African American controls
Parkinson's disease (non-familial, age at onset)
1,554 European ancestry cases
2,363 European ancestry cases
1985 European ancestry cases
3100 European ancestry cases
Parkinson's disease (familial, age at onset)
737 European ancestry cases
Thyroid-associated orbitopathy in graves' disease
265 European ancestry cases with thyroid-associated orbitopathy, 147 European ancestry cases without thyroid-associated orbitopathy
319 European ancestry cases with thyroid-associated orbitopathy, 220 European ancestry cases without thyroid-associated orbitopathy
7,619 East Asian ancestry cases, 6,286 East Asian ancestry controls
6,605 East Asian ancestry cases, 8,543 East Asian ancestry controls
Sense of smell
6,252 European ancestry individuals
41,142 European ancestry individuals, 705 East Asian ancestry individuals, 6,287 African American individuals, 1,415 Hispanic individuals
60,827 European ancestry individuals, 9,982 Indian Asian ancestry individuals, 2,710 African American/Afro-Caribbean individuals
40,473 European ancestry individuals, 689 East Asian ancestry individuals, 6,237 African American individuals, 1,381 Hispanic individuals
60,078 European ancestry individuals, 9,729 Indian Asian ancestry individuals, 2,679 African American/Afro-Caribbean individuals
51,430 European ancestry individuals, 702 East Asian ancestry individuals, 6,480 African American individuals, 1,412 Hispanic individuals
71,032 European ancestry individuals, 10,000 Indian Asian ancestry individuals, 2,707 African American/Afro-Caribbean individuals
50,823 European ancestry individuals, 703 East Asian ancestry individuals, 6,476 African American individuals, 1,407 Hispanic individuals
71,921 European ancestry individuals, 9,992 Indian Asian ancestry individuals, 2,685 African American/Afro-Caribbean individuals
Metabolite levels (lipid measures)
2,118 Erasmus Rucphen (founder/genetic isolate), 22,807 European ancestry individuals
Affymetrix, Illumina, Perlegen [12133295] (imputed)
Metabolite levels (small molecules and protein measures)
Metabolite levels (lipoprotein measures)
up to 70,460 European ancestry drinker individuals
up to 35,438 European ancestry drinker individuals
Affymetrix, Illumina, Perlegen [at least 316407] (imputed)
up to 74,711 European ancestry heavy and light/non-drinker individuals
up to 31,021 European ancestry heavy and light/non-drinker individuals
271 Chinese ancestry cases, 247 Chinese ancestry controls
9,633 Chinese ancestry cases, 11,839 Chinese ancestry controls
167 East Asian ancestry cases, 900 East Asian ancestry controls
Neuroendocrine tumor
832 European ancestry cases, 4,542 European ancestry controls.
Small intestine neuroendocrine tumor
293 European ancestry cases, 4,542 European ancestry controls, up to 241 controls
Pancreatic neuroendocrine tumor
156 European ancestry cases, 4,542 European ancestry controls
Bronchial neuroendocrine tumor
128 European ancestry cases, 4,542 European ancestry controls
48 European ancestry cases, 18 European ancestry extreme cases, 5,583 European ancestry controls
161 cases, 249 clozapine-exposed controls, 947 unexposed controls
Gait variability
2,946 individuals
Gait rhythm
Tandem gait
51 European ancestry infant cases, 14 Asian ancestry infant cases, 8 mixed European/Asian infant cases, 119 European ancestry non-allergic infant controls, 10 Asian ancestry non-allergic infant controls, 19 mixed European/Asian non-allergic infant controls
604 European ancestry infant cases, 34 mixed European/Asian infant cases, 2,871 European ancestry non-allergic infant controls, 40 mixed European/Asian non-allergic infant controls, 589 European ancestry infant controls, 1,148 European ancestry parent controls
298,420 Korculan (founder/genetic isolate), Split (founder/genetic isolate), Vis (founder/genetic isolate), Erasmus Rucphen (founder/genetic isolate) and other European ancestry individuals
Affymetrix, Illumina, Perlegen [at least 5170349] (imputed)
166,205 European ancestry individuals
180,281 Korculan (founder/genetic isolate), Split (founder/genetic isolate), Vis (founder/genetic isolate), Erasmus Rucphen (founder/genetic isolate) and other European ancestry individuals
105,739 European ancestry individuals, 16,471 European ancestry major depressive disorder cases, 58,835 European ancestry controls
368,890 European ancestry individuals
170,911 European ancestry individuals
Developmental language disorder
149 isolated population cases, 210 isolated population controls
Developmental language disorder (linguistic errors)
Developmental language disorder (syntactic complexity)
Discordance in emotional problems in monozygotic twins
up to 1,026 child monozygotic twin pairs
up to 201,529 European ancestry individuals
up to 140,886 European ancestry individuals
Targeted genotyping array [CardioMetaboChip]
Excessive daytime sleepiness
111,648 European ancestry individuals
111,975 European ancestry individuals
Sleep traits (multi-trait analysis)
At least 112,586 European ancestry individuals
up to 12,674 European ancestry male cases, up to 19,481 European ancestry female cases, up to 16,009 European ancestry male controls, up to 10,964 European ancestry female controls,
945 Japanese ancestry cases, 1,213 Japanese ancestry controls
1,396 Japanese ancestry cases, 1,268 Japanese ancestry controls, 1,319 European ancestry cases, 514 European ancestry controls, 971 Polynesian ancestry cases, 565 Polynesian ancestry controls
619 Japanese ancestry cases, 1,213 Japanese ancestry controls
696 Japanese ancestry cases, 1,268 Japanese ancestry controls
560 Japanese ancestry cases, 1,213 Japanese ancestry controls
618 Japanese ancestry cases, 1,268 Japanese ancestry controls
Nonsyndromic cleft lip with cleft palate
2,033 Han Chinese ancestry cases, 4,051 Han Chinese ancestry controls
1,346 Han Chinese ancestry cases, 4,542 Han Chinese ancestry controls
Anti-thyroid drug induced agranulocytosis
38 European ancestry cases, 1 case, 5,170 European ancestry controls
Non-chemotherapy drug induced agranulocytosis
222 European ancestry cases, 12 cases, 5,170 European ancestry controls
Neuropathic pain in type 2 diabetes
470 European ancestry male cases, 491 European ancestry female cases, 2,021 European ancestry male controls, 1,239 European ancestry female controls
Affymetrix, Illumina [6906962] (imputed)
Liver fibrosis severity in HIV/hepatitis C co-infection
289 French ancestry cases
1,553 Swedish ancestry cervical intraepithelial neoplasia grade 3 cases, 81 Swedish ancestry cervical cancer cases, 4,442 Swedish ancestry controls
827 Swedish ancestry cervical intraepithelial neoplasia grade 3 cases, 123 Swedish ancestry cervical cancer cases, 1,715 European ancestry controls
Celiac disease and Rheumatoid arthritis
371 South Asian ancestry celiac disease cases, 3,138 European ancestry celiac disease cases, 4,418 European ancestry rheumatoid arthritis cases, 509 South Asian ancestry celiac disease controls, 2,473 European ancestry celiac disease controls, 3,300 European ancestry rheumatoid arthritis controls, 8,872 celiac disease cases, 9,401 rheumatoid arthritis cases, 4,845 celiac disease controls, 9,627 rheumatoid arthritis controls
Diastolic blood pressure response to hydrochlorothiazide in hypertension
1,739 European ancestry individuals
430 African American individuals
Systolic blood pressure response to hydrochlorothiazide in hypertension
Ideal cardiovascular health (clinical and behavioural)
883 European ancestry individuals with clinical and behavioral ideal cardiovascular health, 10,825 European ancestry individuals without clinical and behavioral ideal cardiovascular health
522 European ancestry individuals
Ideal cardiovascular health (clinical)
2,242 European ancestry individuals with clinical ideal cardiovascular health, 9,466 European ancestry individuals without clinical ideal cardiovascular health
1,235 Hispanic individuals, 706 Asian ancestry individuals, 1,549 African American individuals, 2,395 European ancestry individuals
3,379 Hispanic individuals, 6,871 African American individuals
Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia
71 cases with pancreatitis, 142 cases without pancreatitis
Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time)
46 European ancestry cases with pancreatitis, 3,023 European ancestry cases without pancreatitis, 11 Black cases with pancreatitis, 339 Black cases without pancreatitis, 46 Hispanic cases with pancreatitis, 1,131 Hispanic cases without pancreatitis, 1 Asian ancestry case with pancreatitis, 98 Asian ancestry cases without pancreatitis, 13 cases with with pancreatitis, 477 cases without pancreatitis
2,165 Saudi Arab ancestry cases, 2,266 Saudi Arab ancestry controls
503 Saudi Arab ancestry cases, 734 Saudi Arab ancestry controls
2,563 Saudi Arab ancestry cases, 1,868 Saudi Arab ancestry controls
866 Saudi Arab ancestry cases, 371 Saudi Arab ancestry controls
middle facial morphology traits (ordinal measurement)
5,958 Latin American ancestry individuals
501 Latin American ancestry individuals
lower facial morphology traits (ordinal measurement)
middle facial morphology traits (quantitative measurement)
2955 Latin American ancestry individuals.
lower facial morphology traits (quantitative measurement)
facial morphology traits (multivariate analysis)
upper facial morphology traits (ordinal measurement)
437 European ancestry individuals, 364 African American individuals, 453 Latino individuals, 674 Japanese American individuals, 311 Native Hawaiian ancestry individuals
1,737 African American cases, 3,602 African American controls
866 African American cases, 796 African American controls
2029 African American current smoker individuals, 1748 African American former smoker individuals
up to 4737 African American individuals
Lung adenocarcinoma
739 African American cases, 3,601 African American controls
up to 311 African American cases, up to 1,137 African American controls
Squamous cell lung carcinoma
up to 400 African American cases, up to 3,601 African American controls
up to 192 African American cases, up to 1,137 African American controls
4,888 German ancestry cases, 10,395 German ancestry controls
2,903 Sardinian ancestry cases, 3,323 Sardinian ancestry controls
2,511 European ancestry cases, 1,382 European ancestry controls
Aggressive prostate cancer
1,394 European ancestry aggressive cases, 1,117 European ancestry less-aggressive cases
Adverse response to dabrafenib or dabrafenib-trametinib treatment in melanoma (pyrexia)
218 European ancestry cases with pyrexia, 361 European ancestry exposed cases without pyrexia
Affymetrix, Illumina [6000000] (imputed)
Bone mineral density (Ward's triangle area)
4,305 European ancestry individuals,1,579 Chinese Han ancestry individuals, 845 African-American individuals, 446 Hispanic individuals
Affymetrix, Illumina [at least 9551331] (imputed)
4,939 European ancestry estrogen receptor-negative cases, 14,352 European ancestry controls
7,333 European ancestry estrogen receptor-negative cases, 7,797 European ancestry BRCA1 mutation carrier cases, 7,455 European ancestry BRCA1 mutation carrier controls, 42,468 European ancestry controls
4,939 European ancestry cases, 14,352 European ancestry controls
425 Irish ancestry cases, 453 Irish ancestry controls
11,812 European ancestry cases, 229 Indian ancestry cases, 11,837 European ancestry controls, 391 Indian ancestry controls
Serum parathyroid hormone levels
up to 22,653 European ancestry individuals.
6,502 European ancestry individuals.
Affymetrix, Illumina, Perlegen [8559187] (imputed)
Heroin dependence
370 Han Chinese ancestry cases, 134 Han Chinese ancestry controls
Urinary electrolytes (magnesium/calcium ratio)
7,498 European ancestry individuals, 1,541 Val Borbera (founder/genetic isolated) individuals, 281 Carlantino (founder/genetic isolated) individuals
Abdominal aortic aneurysm
4,972 European ancestry cases, 99,858 European ancestry controls
2,482 European ancestry cases, 2,750 cases, 2,645 European ancestry controls, 5,263 controls
Affymetrix, Illumina [5363770] (imputed)
91,370 European ancestry individuals, 15,346 individuals
Cluster headache
99 Italian ancestry cases, 359 Italian ancestry smoker controls
Tonsillectomy
1,464 Northwestern European ancestry cases and 12,019 Northwestern European ancestry controls.
1,575 Northwestern European ancestry cases and 1,367 Northwestern European ancestry controls.
6,348 European ancestry responder cases, 3,340 European ancestry non-responder cases
Response to citalopram or escitalopram in depression
2,963 European ancestry responder cases, 2,005 European ancestry non-responder cases
Response to antidepressants in depression
7,795 European ancestry responder cases, 1,311 European ancestry non-responder cases
Non-response to bupropion and depression
1,861 European ancestry non-responder cases, 192,070 European ancestry healthy controls
Response to bupropion and depression
2,675 European ancestry responder cases, 191,986 European ancestry healthy controls
Response to selective serotonin reuptake inhibitors and depression
6,348 European ancestry responder cases, 191,357 European ancestry healthy controls
Non-response to citalopram or escitalopram and depression
2,005 European ancestry non-responder cases, 192,083 European ancestry healthy controls
Response to citalopram or escitalopram and depression
2,963 European ancestry responder cases, 191,936 European ancestry healthy controls
Non-response to antidepressants and depression
1,311 European ancestry non-responder cases, 192,178 European ancestry healthy controls
Non-response to selective serotonin reuptake inhibitors and depression
3,340 European ancestry non-responder cases, 191,882 European ancestry healthy controls
Response to antidepressants and depression
7,795 European ancestry responder cases, 191,173 European ancestry healthy controls
Response to bupropion in depression
2,675 European ancestry responder cases, 1,861 European ancestry non-responder cases
Posterior cortical atrophy and Alzheimer's disease
293 cases, 10,547 healthy controls
Systemic juvenile idiopathic arthritis
178 European ancestry cases, 434 European ancestry controls, 81 Hispanic/Latin American cases, 177 Hispanic/Latin American controls, 511 cases, 6,336 controls
QT interval (sulfonylurea treatment interaction)
2,095 European ancestry exposed individuals, 42,907 European ancestry unexposed individuals, 1,167 African American exposed individuals, 10,564 African American unexposed individuals, 794 Hispanic/Latino American exposed individuals, 14,330 Hispanic/Latino American unexposed individuals
JT interval (sulfonylurea treatment interaction)
QRS interval (sulfonylurea treatment interaction)
1,611 Hispanic cases, 4,330 Hispanic controls
Monocyte-lymphocyte ratio
5,892 Dutch ancestry individuals
Affymetrix, Illumina, Perlegen [5987253] (imputed)
Sciatica caused by lumbar disc herniation (treated with microdiscectomy)
3,097 Icelandic ancestry cases, 1,651 non-array typed, familial imputed Icelandic ancestry cases, 132,966 Icelandic ancestry controls, 149,624 non-array typed, familial imputed Icelandic ancestry controls
Thiopurine S-methyltransferase activity
844 European ancestry individuals (blood measurement), 123 European ancestry individuals (liver measurement), 245 acute lymphoblastic leukemia cases (blood measurement)
Educational attainment (years of education)
405,072 European ancestry individuals
Affymetrix, Illumina, Perlegen [~ 9300000] (imputed)
Educational attainment (college completion)
280,007 European ancestry individuals
Response to dendritic cell-based immunotherapy in HIV infection
7 Spanish good responders, 8 Brazilian good responders, 8 Spanish poor responders, 10 Brazilian poor responders.
Macular telangiectasia type 2
476 European ancestry cases, 1,733 European ancestry controls
172 European ancestry cases, 1,134 European ancestry controls
Presence of antiphospholipid antibodies
4,163 German ancestry individuals
Midgestational circulating levels of organochlorine pesticides
329 Hispanic mothers, 273 European ancestry mothers, 122 Asian ancestry mothers, 23 South Asian ancestry mothers, 21 African American mothers, 22 other ancestry mothers
Midgestational circulating levels of PCBs (fetal genetic effect)
764 fetuses
Midgestational circulating levels of PBDEs
Midgestational circulating levels of PBDEs (fetal genetic effect)
Midgestational circulating levels of organochlorine pesticides (fetal genetic effect)
Midgestational circulating levels of PCBs
Loneliness (multivariate analysis)
8,490 European ancestry individuals, 1,228 African American individuals, 867 Hispanic American individuals, 175 individuals
2,075 European ancestry cases, 3,875 European ancestry controls, 427 African American cases, 398 African American controls, 294 Hispanic cases, 327 Hispanic controls, 57 cases, 73 controls
Loneliness (linear analysis)
534 Han Chinese ancestry individuals
547 East Asian ancestry individuals
3,146 individuals
347 Indian ancestry cases, 354 Indian ancestry controls
319 Indian ancestry cases, 297 Indian ancestry controls
2,729 Korean ancestry individuals
1,547 Han Chinese ancestry individuals, 3,237 European ancestry individuals
1,547 Chinese Han ancestry individuals, 3,237 European ancestry individuals
Maximal oxygen uptake response
79 Korean ancestry individuals
knee peak torque response
998 Han Chinese ancestry children
599 Han Chinese ancestry children
5,020 European ancestry lung cancer cases, 3,718 European ancestry lung adenocarcinoma cases, 3,422 European ancestry lung squamous cell carcinoma cases, 15,414 European ancestry colorectal cancer cases, 10,809 European ancestry breast cancer cases, 4,939 European ancestry estrogen receptor negative breast cancer cases, 1,098 European ancestry ovarian cancer cases, 2,556 European ancestry serous ovarian cancer cases, 715 European ancestry ovarian endometrioid carcinoma cases, 9,710 European ancestry prostate cancer cases, 4,450 European ancestry aggressive prostate cancer cases, 61,820 European ancestry controls
Affymetrix, Illumina [9916564] (imputed)
4,907 European ancestry cases, 11,945 European ancestry controls
Arthritis (juvenile idiopathic)
388 European ancestry cases, 2,500 European ancestry controls
778 European ancestry cases, 7,000 European ancestry controls
Depressive symptoms measurement (somatic complaints domain)
1,107 Erasmus Rucphen (founder/genetic isolate) individuals, 31,421 European ancestry individuals
6,813 European ancestry individuals
Affymetrix, Illumina [at least 1069063] (imputed)
Depressive symptoms measurement (lack of negative affect domain)
Depressive symptoms measurement (lack of positive affect domain)
2,717 European ancestry oral cavity cancer cases, 273 oral cavity cancer cases, 2,506 European ancestry oropharynx cancer cases, 135 oropharynx cancer cases, 305 European and unknown ancestry hypopharynx cancer cases, 73 European and unknown ancestry overlapping cases, 25 European and unknown ancestry cases, 5,984 European ancestry controls, 601 controls
2,506 European ancestry cases, 135 cases, 5,984 European ancestry controls, 601 controls
2,717 European ancestry cases, 273 cases, 5,984 European ancestry controls, 601 controls
315 Han Chinese ancestry cases, 1,115 Han Chinese ancestry controls
282 Han Chinese ancestry cases, 480 Han Chinese ancestry controls
1,374 European ancestry cases and 6,468 European ancestry controls from 7,694 twin pairs
Affymetrix, Illumina, Perlegen [6464174] (imputed)
Extraversion
63,030 European ancestry individuals
9,783 European ancestry individuals
Affymetrix, Illumina, Perlegen [6941603] (imputed)
6,602 Sardinian founder individuals
4,131 European ancestry individuals
960 Han Chinese ancestry cases, 1,499 Han Chinese ancestry controls
3,316 Han Chinese ancestry cases, 4,516 Han Chinese ancestry controls
Myositis
1,710 European ancestry cases, 4,724 European ancestry controls
Bone mineral density (spine) and age at menarche
826 Han Chinese ancestry females
1,728 European ancestry females, 709 African American females, 408 Hispanic/Latin American females
Bone mineral density (hip) and age at menarche
Soluble interleukin-2 receptor subunit alpha
2,964 European ancestry individuals, 683 African American individuals
4,464 European ancestry individuals
Postburn hypertrophic scarring severity
408 European ancestry individuals, 26 Asian ancestry individuals, 19 African American individuals, 11 Native American ancestry individuals, 74 individuals
up to 2,484 European ancestry individuals, up to 70 African American individuals, up to 2 Native American or Alaska Native ancestry individuals, up to 85 Asian American individuals, up to 7 Native Hawaiian or other Pacific islander individuals, up to 44 mixed ancestry individuals
1,032 European ancestry individuals, 98 African American individuals, 4 Native American or Alaska Native ancestry individuals, 43 Asian American individuals, 7 Native Hawaiian or other Pacific islander individuals, 78 mixed ancestry individuals
Eating disorder in bipolar disorder
184 European ancestry cases, 2,006 European ancestry controls
Bipolar disorder and eating disorder
184 European ancestry cases with bipolar disorder and eating disorder, 1,370 European ancestry controls
2,006 European ancestry bipolar disorder without eating disorder cases, 1,370 European ancestry controls
Response to serotonin reuptake inhibitors in non-psychotic unipolar depression
263 Korean ancestry responder cases, 218 Korean ancestry non-responder cases
118 Korean ancestry responder cases, 112 Korean ancestry non-responder cases
810 Chinese ancestry individuals
Suicide behavior
577 European ancestry cases, 1,233 European ancestry controls
Suicide ideation score in major depressive disorder
358 European ancestry individuals
Suicide
317 European ancestry cases, 1,233 European ancestry controls
Suicide attempts in major depressive disorder
257 European ancestry cases, 300 European ancestry controls
Corticobasal degeneration
152 cases, 3,111 controls
67 cases, 457 controls
152 cases, 1,986 controls
Lung disease severity in cystic fibrosis
4,139 European and other ancestry p.Phe508del homozygote cases, 2,226 European and other ancestry cases
White matter lesion progression
1,085 European ancestry elderly cases, 6,688 European ancestry elderly controls
Affymetrix, Illumina [up to 2543887] (imputed)
White matter lesion progression (adjusted for white matter lesion burden at baseline)
Acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation
39 cases, 29 controls
45 cases, 55 controls
7,638 cases, 7,364 controls
2,287 cases, 4,205 controls
Response to montelukast in asthma (change in FEV1)
88 European ancestry cases, 10 African ancestry cases, 35 Asian ancestry cases
101 European ancestry cases, 33 African ancestry cases, 50 Asian ancestry cases
Platinum-induced hepatotoxicity in non-small cell lung cancer
329 Han Chinese ancestry cases
375 Han Chinese ancestry cases
Joint damage progression in ACPA-negative rheumatoid arthritis
262 Western European ancestry cases
253 Western European ancestry cases
Ear protrusion
4,919 Latin American individuals
Tragus size
Antitragus size
Crus helix expression
Superior crus of antihelix expression
Darwin's tubercle
Ear morphology
Lobe size
Lobe attachment
Helix rolling
Folding of antihelix
949 non-Hispanic black individuals, 759 European ancestry individuals
Setpoint viral load in HIV-1 infection
6,315 European ancestry cases
Affymetrix, Illumina [~ 8000000] (imputed)
8,344 Han Chinese ancestry individuals
14,739 Han Chinese ancestry individuals
Affymetrix, Illumina [2573667] (imputed)
Major depressive disorder (stressful life events interaction)
308 East Asian ancestry prepressive cases, 780 East Asian ancestry non-depressive controls
Body mass index variance
14,131 Pakistani ancestry individuals
12,874 European ancestry cases, 23,203 European ancestry controls
785 European ancestry cases, 791 European ancestry controls, 2,331 cases, 2,415 controls
Affymetrix, Illumina [at least 1569314] (imputed)
Attention function in attention deficit hyperactive disorder
479 European ancestry adult cases
Warfarin maintenance dose
180 Brazilian ancestry low dose individuals, 187 Brazilian ancestry high dose individuals
798 European ancestry individuals, 1611 Japanese ancestry individuals, 191 African American individuals
Staphylococcus aureus nasal carriage (persistent)
141 Mexican American persistent carrier individuals, 620 Mexican American non-carrier individuals
Affymetrix, Illumina [at least 603042] (imputed)
Staphylococcus aureus nasal carriage (intermittent)
97 Mexican American intermittent carrier individuals, 620 Mexican American non-carrier individuals
2,895 African American individuals
1,505 Ashkenazi Jewish founder cases, 2,553 Ashkenazi Jewish founder controls
592 Ashkenazi Jewish ancestry cases, 505 Ashkenazi Jewish ancestry controls, 36,989 cases, 113,075 controls
31,516 East Asian ancestry individuals, 35,352 European ancestry individuals, 33,126 South Asian ancestry individuals
87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals and 16,328 South Asian ancestry individuals
Affymetrix, Illumina, Perlegen [2127883] (imputed)
Affymetrix, Illumina, Perlegen [~ 2100000] (imputed)
Mean arterial pressure
87,205 individuals, 48,268 East Asian ancestry individuals, 68,456 European ancestry individuals, 16,328 South Asian ancestry individuals
148 Japanese ancestry individuals
374 Japanese ancestry individuals
Mitral valve prolapse
1,442 European ancestry cases, 2,439 European ancestry controls
1,422 European ancestry cases, 6,779 European ancestry controls
Affymetrix, Illumina [~ 4800000] (imputed)
Cardiovascular disease in hypertension (ACE inhibitor interaction)
Up to 3,527 European ancestry individuals with cardiovascular disease, up to 11,848 European ancestry individuals without cardiovascular disease
Up to 1,751 European ancestry individuals with cardiovascular disease, up to 1,267 African American ancestry individuals with cardiovascular disease, up to 2,874 African American ancestry individuals without cardiovascular disease
Affymetrix, Illumina [1892626] (imputed)
Cardiovascular disease in hypertension (calcium channel blocker interaction)
Affymetrix, Illumina [1807456] (imputed)
Myocardial infarction in hypertension (calcium channel blocker interaction)
Up to 2,114 European ancestry individuals with myocardial infarction, up to 13,261 European ancestry individuals without myocardial infarction
Up to 1,171 European ancestry individuals with myocardial infarction
Affymetrix, Illumina [1194322] (imputed)
Cardiovascular disease in hypertension (diuretic interaction)
Affymetrix, Illumina [2030893] (imputed)
Cardiovascular disease in hypertension (beta blocker interaction)
Affymetrix, Illumina [1971049] (imputed)
Myocardial infarction in hypertension (ACE inhibitor interaction)
Affymetrix, Illumina [1465692] (imputed)
Myocardial infarction in hypertension (beta blocker interaction)
Affymetrix, Illumina [1780479] (imputed)
Myocardial infarction in hypertension (diuretic interaction)
Up to 2,114 European ancestry individuals with myocardial infarction, up to 13,261 European ancestry individuals myocardial infarction
Affymetrix, Illumina [1822485] (imputed)
Cerebrospinal fluid clusterin levels
300 Alzheimer's disease cases, 373 controls
Plasma clusterin levels
521 Alzheimer's disease cases, 297 controls
Cerebrospinal fluid clusterin levels in APOEe4- carriers
123 Alzheimer's disease cases, 270 controls
Cerebrospinal fluid clusterin levels in APOEe4+ carriers
177 Alzheimer's disease cases, 103 controls
530 European ancestry cases, 926 European ancestry controls
LDL peak particle diameter (total fat intake interaction)
Influenza A (H1N1) severity
49 European ancestry severe cases, 107 European ancestry mild cases
Influenza A (H1N1) infection
49 European ancestry severe cases, 107 European ancestry mild cases, 549 European ancestry population controls
Mild influenza (H1N1) infection
107 European ancestry mild cases, 549 European ancestry population controls
Severe influenza A (H1N1) infection
49 European ancestry severe cases, 549 European ancestry population controls
250 Han Chinese ancestry cases, 250 Han Chinese ancestry controls
Urinary metabolites
3,861 European ancestry individuals
1,691European ancestry individuals
76 Han Chinese ancestry child cases, 186 Han Chinese ancestry child controls
9,137 European ancestry mild cases, 4,881 European ancestry moderate cases, 3,056 European ancestry severe cases
2,662 European ancestry mild cases, 3,044 European ancestry moderate cases, 1,763 European ancestry severe cases
3,000 East Asian ancestry cases, 4,394 East Asian ancestry controls
3,605 East Asian ancestry cases, 3,919 East Asian ancestry controls
Plasma lactate levels
6,901 European ancestry individuals
1,671 African American individuals
5,184 European ancestry cases, 82,759 European ancestry controls
374 European ancestry cases, 92,681 European ancestry controls, 1,671 cases, 6,205 controls
5,130 African ancestry cases, 5,291 African ancestry controls
5,535 African ancestry cases, 9,948 African ancestry controls
Antipsychotic drug-induced weight gain
189 European ancestry treated schizophrenia cases
86 European ancestry treated schizophrenia or schizoaffective cases
Antipsychotic drug-induced weight gain (time interaction)
Cingulate cortical amyloid beta load
215 European ancestry early mild cognitive impairment cases, 152 European ancestry late mild cognitive impairment cases, 45 European ancestry Alzheimer disease cases, 190 European ancestry controls
Acylcarnitine levels
up to 7,478 European ancestry individuals
1,182 European ancestry individuals
Affymetrix, Illumina [at least 296619] (imputed)
Amino acid levels
Glycerophospholipid levels
Sphingolipid levels
Affymetrix, Illumina [up to 296619] (imputed)
Hexose levels
7,478 European ancestry individuals
Staphylococcus aureus infection
4,701 European ancestry cases, 45,344 European ancestry controls
Skin and soft tissue Staphylococcus aureus infection
2,130 European ancestry cases, 45,434 European ancestry controls
Asthma exacerbations
581 European ancestry cases
652 European ancestry cases, 212 African American cases, 127 cases
Arterial stiffness (pulse-wave velocity)
402 Korean ancestry individuals
1206 Korean ancestry individuals
1,003 European ancestry invasive cases, 641 European ancestry low malignant potential cases, 21,693 European ancestry controls
Longitudinal alcohol consumption
2,126 adolescents and early adults
Late-onset myasthenia gravis
532 European ancestry cases, 2,128 European ancestry controls
Prostate cancer (survival)
7,322 cases
18,197 European ancestry cases
Affymetrix, Illumina [up to 9536409] (imputed)
Noise-induced hearing loss
19 European and Mexican ancestry exposed individuals with hearing loss, 22 European and Mexican ancestry exposed individuals without hearing loss
100 European ancestry cases, 92 European ancestry controls
100 European ancestry cases, 407 European ancestry controls
Blond vs non-blond hair color
2,888 European ancestry blond hair individuals, 4,203 European ancestry non-blond hair individuals
Affymetrix, Illumina, Perlegen [6473680] (imputed)
Brown vs. non-brown hair color
3,826 European ancestry brown hair individuals, 3,265 European ancestry non-brown hair individuals
Light vs. dark hair color
3,069 European ancestry light hair individuals, 4,022 European ancestry dark hair individuals
Red vs non-red hair color
181 European ancestry red hair individuals, 6,910 European ancestry non-red hair individuals
Black vs. non-black hair color
196 European ancestry black hair individuals, 6,895 European ancestry non-black hair individuals
Trichloroethylene-induced hypersensitivity syndrome
98 Han Chinese ancestry cases, 98 Han Chinese ancestry trichloroethylene-tolerant controls
Up to 74 Han Chinese ancestry cases, up to 1,661 Han Chinese ancestry trichloroethylene-tolerant controls
1,255 Han Chinese ancestry male cases, 1,848 Han Chinese ancestry male controls
3,020 Han Chinese ancestry male cases, 4,424 Han Chinese ancestry male controls
Asperger syndrome
294 European ancestry cases, 318 European ancestry controls
Pediatric autoimmune diseases
97 European ancestry thyroiditis cases, 107 European ancestry ankylosing spondylitis cases, 100 European ancestry psoriasis cases, 173 European ancestry celiac disease cases, 254 European ancestry systemic lupus erythematosus cases, 308 European ancestry common variable inmunodeficiency cases, 865 European ancestry ulcerative colitis cases, 1,086 European ancestry Type 1 diabetes cases, 1,123 European ancestry juvenile idiopathic arthritis cases, 1,922 European ancestry Crohn's disease cases, 10,718 European ancestry controls
94 Taiwanese Han ancestry cases, 376 Taiwanese Han ancestry controls
Anthracycline-induced cardiotoxicity in childhood cancer
32 European ancestry cases with cardiotoxicity, 248 European ancestry cases without cardiotoxicity
22 European ancestry cases with cardiotoxicity, 74 European ancestry cases without cardiotoxicity, 2 African cases with cardiotoxicity, 9 African cases without cardiotoxicity, 5 Hispanic cases with cardiotoxicity, 18 Hispanic cases without cardiotoxicity, 8 East Asian cases with cardiotoxicity, 23 East Asian cases without cardiotoxicity, 4 Aboriginal Canadian cases with cardiotoxicity, 11 Aboriginal Canadian cases without cardiotoxicity
2,764 European ancestry cases, 10,475 European ancestry controls
3,716 European ancestry cases, 4,261 European ancestry controls
Postoperative atrial fibrillation in coronary artery bypass grafting surgery
620 European ancestry cases, 257 European ancestry controls
220 cases, 84 controls
Rotator cuff tears
311 European ancestry cases, 2,641 European ancestry controls
42,096 European ancestry cases, 361 African American cases, 758 Hispanic American cases, 12,658 South Asian ancestry cases, 1,802 Lebanese ancestry cases, 3,614 East Asian ancestry cases, 99,121 European ancestry controls, 2,778 African American controls, 3,337 Hispanic American controls, 12,899 South Asian ancestry controls, 466 Lebanese ancestry controls, 7,709 East Asian ancestry controls
Affymetrix, Illumina [8600000] (imputed)
27,509 European ancestry cases, 130 African American cases, 278 Hispanic American cases, 10,257 South Asian ancestry cases, 288 Lebanese ancestry cases, 1,687 East Asian ancestry cases, 99,121 European ancestry controls, 2,778 African American controls, 3,337 Hispanic American controls, 12,899 South Asian ancestry controls, 466 Lebanese ancestry controls, 7,709 East Asian ancestry controls
2,451 Caribbean Hispanic cases, 2,063 Caribbean Hispanic controls
550 Caribbean Hispanic cases, 236 Caribbean Hispanic controls
Affymetrix, Illumina [8837542] (imputed)
737 European ancestry females
Adiponectin levels (BMI-adjusted)
120,246 European ancestry individuals
Affymetrix, Illumina [~ 10700000] (imputed)
up to 1,365 African American cases, up to 13,154 African American controls
European ancestry individuals (see Traylor, 2012)
up to 1,592 African American cases, up to 13,154 African American controls
Affymetrix, Illumina [up to 2600000] (imputed)
2,350 East Asian ancestry cases, 2,708 East Asian ancestry controls
7,408 East Asian ancestry cases, 7,548 East Asian ancestry controls
Cardia gastric cancer
1,189 East Asian ancestry cases, 2,708 East Asian ancestry controls
3,738 East Asian ancestry cases, 7,548 East Asian ancestry controls
1,027 East Asian ancestry cases, 2,708 East Asian ancestry controls
3,663 East Asian ancestry cases, 7,548 East Asian ancestry controls
Dysphagia
71 European ancestry older adult cases, 484 European ancestry older adult controls
853 African American cognitively normal individuals, 45 African American dementia cases, 934 Yoruban ancestry cognitively normal individuals, 26 Yoruban ancestry dementia cases
Thionamide-induced agranulocytosis in Graves' disease
21 East Asian ancestry cases with agranulocytosis, 662 East Asian ancestry cases without agranulocytosis
21 East Asian ancestry cases with agranulocytosis, 546 East Asian ancestry cases without agranulocytosis
18,299 European ancestry cases, 19,656 European ancestry controls
4,725 East Asian ancestry cases, 9,969 East Asian ancestry controls
12,491 Hispanic/Latin American individuals
7,170 Hispanic/Latin American individuals
5,530 European ancestry cases, 5,607 European ancestry controls
1,085 Russian ancestry cases, 2,865 Russian ancestry controls, 2,277 Sub-Saharan African ancestry cases, 2,360 Sub-Saharan African ancestry controls
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder
750 European ancestry child and adolescent cases
MGMT methylation in smokers
296 European ancestry individuals with MGMT methylation, 867 European ancestry individuals without MGMT methylation
107 European and Hispanic individuals with MGMT methylation, 323 European and Hispanic individuals without MGMT methylation
Lung cancer (asbestos exposure interaction)
833 European ancestry cases, 739 European ancestry controls
2,960 European ancestry cases, 2,646 European ancestry controls
Ultraviolet-induced skin pigmentation (minimal erythema dose)
99 Korean ancestry individuals
112 Korean ancestry individuals
Post-bronchodilator lung function in asthma (FEV1)
447 Puerto Rican ancestry cases
568 European, black or Hispanic cases, 2,414 Hispanic cases
Post-bronchodilator lung function in asthma (FEV1/FVC)
Left superior temporal gyrus thickness (schizophrenia interaction)
113 schizophrenia cases, 126 controls
Postprandial triglyceride response to high fat diet meal
872 European ancestry individuals
843 Old Order Amish individuals
Platelet thrombus formation
125 European ancestry individuals, 116 African American individuals
79 Ashkenazi Jewish (founder/genetic isolate) GBA mutation carriers
34 Ashkenazi Jewish (founder/genetic isolate) mild GBA mutation carriers, 41 Ashkenazi Jewish (founder/genetic isolate) severe GBA mutation carriers
Response to anthracycline-based chemotherapy in breast cancer (pathologic complete response)
30 East Asian ancestry responder cases, 62 East Asian ancestry non-responder cases
62 East Asian ancestry responder cases, 339 East Asian ancestry non-responder cases
Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours)
116 Japanese ancestry individuals
234 Japanese ancestry individuals
Diabetic kidney disease
1,564 African American cases, 369 African American diabetic controls, 1,288 African American non-diabetic controls, 538 American Indian ancestry cases, 319 American Indian ancestry diabetic controls, 342 European ancestry cases, 404 European ancestry diabetic controls, 779 Mexican ancestry cases, 594 Mexican ancestry diabetic controls
950 African American cases, 50 African American diabetic controls, 1,887 African American non-diabetic controls, 471 American Indian ancestry cases, 340 American Indian ancestry diabetic controls, 486 American Indian ancestry non-diabetic controls, 582 European ancestry ancestry cases, 205 European ancestry diabetic controls, 2,568 European ancestry non-diabetic controls
up to 1,564 African American cases, 369 African American diabetic controls, 1,288 African American non-diabetic controls, 538 American Indian ancestry cases, 319 American Indian ancestry diabetic controls, 342 European ancestry cases, 404 European ancestry diabetic controls, 779 Mexican ancestry cases, 594 Mexican ancestry diabetic controls
661 European ancestry cases, 487 European ancestry controls
4,467 European ancestry cases, 9,114 European ancestry controls
156 Japanese ancestry cases, 620 Japanese ancestry controls
205 Japanese ancestry cases, 184 Japanese ancestry controls, 418 Han Chinese ancestry cases and 836 Han Chinese ancestry controls from 418 trios
Metastasis at diagnosis in osteosarcoma
122 European ancestry cases with metastasis, 419 European ancestry cases without metastasis
43 European ancestry cases with metastasis, 22 African ancestry cases with metastasis, 40 Brazilian ancestry cases with metastasis, 183 European ancestry cases without metastasis, 39 African ancestry cases without metastasis, 67 Brazilian ancestry cases without metastasis
Acute kidney injury in coronary artery bypass surgery (creatinine rise)
873 European ancestry cases
380 European ancestry cases
Advanced glycation end-product levels
581 Black individuals, 1,737 European ancestry individuals
Juvenile osteochondritis dissecans
209 European ancestry cases, 1,855 European ancestry controls
793 African American cases, 948 African American controls, 606 Hispanic cases, 305 Hispanic controls
Pelvic organ prolapse (moderate/severe)
154 African American cases, 948 African American controls, 163 Hispanic cases, 305 Hispanic controls
2,500 European ancestry cases, 205,652 European ancestry controls (includes non-array genotyped, whole genome imputed individuals)
Gastric adenocarcinoma (histologically verified)
2,043 European ancestry cases, 202,533 European ancestry controls
350 Korean ancestry cases, 700 Korean ancestry controls
310 Korean ancestry cases, 604 Korean ancestry controls
Response to lithium treatment in bipolar disorder
2,563 European ancestry and East Asian ancestry individuals
Affymetrix, Illumina [> 6000000] (imputed)
Survival in colorectal cancer
up to 2,843 European ancestry cases without distant metastases, up to 462 European ancestry cases with distant metastases, up to 189 European ancestry cases of unknown stage
up to 3,205 European ancestry cases without distant metastases, up to 435 European ancestry cases with distant metastases, up to 124 European ancestry cases of unknown stage
Survival in colorectal cancer (non-distant metastatic)
up to 2,843 European ancestry cases
up to 3,205 European ancestry cases
Survival in colorectal cancer (distant metastatic)
up to 462 European ancestry cases
up to 435 European ancestry cases
Cardiomyopathy in childhood cancer survivors (anthracycline treatment interaction)
112 European ancestry cases, 219 European ancestry controls
21 European ancestry cases, 12 Hispanic cases, 21 cases
Cardiomyopathy in childhood cancer survivors
Response to Pazopanib in cancer (hepatotoxicity)
Up to 844 European ancestry cases, up to 325 Asian ancestry cases, up to 19 cases
Up to 811 European ancestry cases, up to 114 Asian ancestry cases, up to 77 cases
Triptolide cytotoxicity
55 European ancestry lymphoblastoid cell lines
Affymetrix, Illumina, Perlegen [at least 1978803] (imputed)
34,744 European ancestry children
11,313 European ancestry children
Affymetrix, Illumina [2499691] (imputed)
Esophageal adenocarcinoma
1,516 European ancestry cases, 3,209 European ancestry controls
874 European ancestry cases, 6,911 European ancestry controls
Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined)
3,928 European ancestry cases, 3,207 European ancestry controls
1,636 European ancestry cases, 6,911 European ancestry controls
2,416 European ancestry cases, 3,206 European ancestry controls
759 European ancestry cases, 6,911 European ancestry controls
994 European ancestry cases, 1,243 European ancestry controls
200 European ancestry cases, 2,120 European ancestry controls
24,740 East Asian ancestry individuals
21,345 East Asian ancestry individuals
Affymetrix, Illumina [up to 2315813] (imputed)
Asthma (corticosteroid response)
124 European ancestry individuals
297 European ancestry individuals
1,190 European ancestry cases, 1,032 cases
Autoimmune hepatitis type-1
649 European ancestry cases, 13,436 European ancestry controls
451 European ancestry cases, 4,103 European ancestry controls
1,737 European ancestry cases, 5,435 European ancestry controls, 129 cases
2,320 European ancestry cases, 40,011 European ancestry controls, 2,042 cases, 3,736 controls
Pulse pressure in young-onset hypertension
382 individuals
559 individuals
Protein C levels
2,701 African American individuals
Type 2 diabetes (young onset) and obesity
99 Chinese ancestry cases, 101 Chinese ancestry controls
534 European ancestry cases, 4,932 European ancestry controls
1,718 European ancestry cases, 1,793 European ancestry controls
Pulmonary function
48,201 individuals
63 European ancestry cases, 543 European ancestry controls, up to 32 African American cases, up to 158 African American controls, up to 4 cases, up to 66 controls
495 European ancestry cases, 981 European ancestry controls, 118 African ancestry cases, 225 African ancestry controls
Urinary albumin excretion rate in type 1 diabetes
1,925 European ancestry cases
3,750 European ancestry cases
Breast cancer (early onset)
3,523 European ancestry young female cases, 2,702 European ancestry young female controls
3,470 European ancestry young female cases, 5,475 European ancestry young female controls
1,893 Latin American cases, 1,881 Latin American controls
EVE Asthma Consortium, see Torgerson et al., 2011
Serum thyroid-stimulating hormone levels
4,501 European ancestry individuals, 351 African American individuals
967 Japanese ancestry individuals, 213 Japanese ancestry asthmatic individuals
1,894 Japanese ancestry individuals, 580 Japanese ancestry asthmatic individuals
3,473 European ancestry twins in 1,905 families, 301 European ancestry thin CCT cases, 301 European ancestry thick CCT controls
3,442 European ancestry adenocarcinoma cases, 3,275 European ancestry squamous cell carcinoma cases, 4,631 cases, up to 15,861 controls
3,589 European ancestry adenocarcinoma cases, 3,202 European ancestry squamous cell carcinoma cases, 3,455 cases, up to 38,295 controls
Hippocampal sclerosis of aging
241 cases, 1,998 controls
122 cases, 305 controls
1443 cases and 99 controls
Periodontal disease-related phenotype (Socransky)
93 European ancestry cases, 83 European ancestry individuals, 497 European ancestry controls
Blood pressure (anthropometric measures interaction)
7,486 Korean ancestry individuals
4,544 East Asian ancestry individuals
Blood pressure
1,505 European ancestry cases, 67,725 European ancestry controls
906 European ancestry cases, 3,772 European ancestry controls
Fractional exhaled nitric oxide (childhood)
5,131 European ancestry individuals, 1,155 Hispanic individuals, 2,572 individuals
Affymetrix, Illumina [2253077] (imputed)
Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity)
176 European ancestry individuals
Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels)
Soluble leptin receptor levels
684 European ancestry type 2 diabetes female cases, 820 European ancestry female controls
875 European ancestry male individuals
Airway responsiveness in chronic obstructive pulmonary disease
Up to 4,108 European American cases
Kidney function decline traits
up to 45,530 European ancestry individuals
up to 18,028 European ancestry individuals
Cervical artery dissection
1,393 European ancestry cases, 14,416 European ancestry controls
659 European ancestry cases, 2,648 European ancestry controls
Heparin-induced thrombocytopenia
57 European ancestry cases, 8 African American cases, 1 other ancestry cases, 1 case, 754 European ancestry controls, 108 African American controls, 6 other ancestry controls, 6 controls, 8 Hispanic controls, 1 Asian control
94 European ancestry cases, 178 European ancestry antibody positive controls, 154 European ancestry antibody negative controls
2,454 European ancestry cases
Response to taxane treatment (placlitaxel)
96 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese ancestry lymphoblastoid cell lines
Response to taxane treatment (docetaxel)
up to 14,900 European ancestry cases, up to 29,485 European ancestry controls
2,338 Han Chinese ancestry cases, 3,077 Han Chinese ancestry controls
229 European ancestry multiple sclerosis cases
409 European ancestry multiple sclerosis cases
3,532 European ancestry cases, 5,120 European ancestry controls
8,381 cases, 48,275 controls
28,517 European ancestry individuals
Response to antipsychotic treatment
Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals
1,496 East Asian ancestry male individuals
Delayed encephalopathy in acute carbon monoxide poisoning
175 Han Chinese ancestry cases, 244 Han Chinese ancestry controls
234 Han Chinese ancestry cases, 271 Han Chinese ancestry controls
Episodic memory
341 European ancestry individuals
472 European ancestry individuals
End-stage renal disease in Type 1 diabetics
258 European ancestry female cases, 935 European ancestry female controls, 387 European ancestry male cases, 655 European ancestry male controls
178 European ancestry female cases, 594 European ancestry female controls, 251 European ancestry male cases, 494 European ancestry male controls, 252 female cases, 479 female controls, 256 male cases, 342 male controls
2,335 European ancestry cases, 7,306 European ancestry controls
2,357 European ancestry cases, 3,684 European ancestry controls
4,931 European ancestry cases, 69,034 European ancestry controls
Otitis media (chronic/recurrent)
373 cases and 229 controls from 143 families
932 European ancestry cases and 652 European ancestry controls from 441 families
Laryngeal squamous cell carcinoma
993 Chinese ancestry cases, 1,995 Chinese ancestry controls
2,398 Chinese ancestry cases, 2,804 Chinese ancestry controls
1,565 European ancestry sproadic Parkinson's disease cases, 435 European ancestry familial Parkinson's disease cases, 1,986 European ancestry controls
1,528 European ancestry sporadic Parkinson's disease cases, 707 European ancestry familial Parkinson's disease cases, 796 European ancestry controls
up to 7,483 European ancestry cases, up to 21,211 European ancestry controls
1,073 European ancestry cases, 1,279 European ancestry controls
1,341 European ancestry cases
1,523 European ancestry cases
32,405 European ancestry cases, 42,221 European ancestry controls, 1,235 European ancestry cases and 1,235 European ancestry controls from 1235 parent-offspring trios, 1,836 East Asian ancestry cases, 3,383 East Asian ancestry controls
1,513 European ancestry cases, 66,236 European ancestry controls
Affymetrix, Illumina [9005918] (imputed)
3,451 Han Chinese ancestry individuals
8,830 Chinese ancestry individuals
Response to radiotherapy in cancer (late toxicity)
579 European ancestry prostate cancer cases, 1,194 European ancestry breast cancer cases
516 European ancestry prostate cancer cases, 862 prostate cancer cases, 355 breast cancer cases
Toenail selenium levels
4,162 European ancestry individuals
Affymetrix, Illumina [2378986] (imputed)
Blood and toenail selenium levels
9,639 European ancestry individuals
Affymetrix, Illumina [2379663] (imputed)
Cortisol levels (plasma)
12,597 European ancestry individuals
2,795 European ancestry individuals
173 European ancestry males and 213 European ancestry females from 21 families
Plasma homocysteine levels (post-methionine load test)
2,710 European and other ancestry individuals, 1,725 European ancestry individuals, 258 African ancestry individuals, 117 individuals
Affymetrix, Illumina [up to 11000000] (imputed)
1,221 individuals
7,365 individuals
123 cases, 112 controls
827 cases, 1,034 controls
Morphine dose requirement in tonsillectomy and adenoidectomy surgery
277 European ancestry children, 241 African American children
75 European ancestry children, 70 African American children
Maternal genotype effects in autism spectrum disorder families
561 European, African American, Asian and other ancestry mothers of autism cases, 547 European, African American, Asian and other ancestry fathers of autism cases, 508 European ancestry females
982 European and other ancestry mothers of autism cases, 1,007 European and other ancestry fathers of autism cases, 743 European and other ancestry females
Chronic lymphocytic leukemia
2,179 European ancestry cases, 6,221 European ancestry controls
1,709 European ancestry cases, 6,318 European ancestry controls
Chronic obstructive pulmonary disease (moderate to severe)
5,812 European ancestry cases, 3,955 European ancestry controls, 821 African American cases, 1,749 African American controls
2,651 cases and their relatives
Chronic obstructive pulmonary disease (severe)
3,145 European ancestry cases, 3,955 European ancestry controls, 352 African American cases, 1,749 African American controls
Asthma (sex interaction)
1,052 European ancestry male cases, 1,019 European ancestry female cases, 709 European ancestry male controls, 826 European ancestry female controls, 675 African American/African Caribbean male cases, 837 African American/African Caribbean female cases, 577 African American/African Caribbean male controls, 926 African American/African Caribbean female controls, 926 Latino male cases, 710 Latino female cases, 410 Latino male controls, 382 Latino female controls
Affymetrix, Illumina [~ 2100000] (imputed)
5,283 European ancestry individuals, 817 African American individuals, 605 individuals
6,687 European ancestry individuals, 711 African American individuals, 363 individuals
182 Japanese ancestry cases, 927 Japanese ancestry controls
782 Japanese ancestry cases, 1,898 Japanese ancestry controls
1,194 Han Chinese ancestry cases, 902 Han Chinese ancestry controls, 1,553 European ancestry cases, 3,050 European ancestry controls
2,491 East Asian ancestry cases, 1,780 East Asian ancestry controls, 2,420 European ancestry cases, 7,222 European ancestry controls
Fetal hemoglobin levels in sickle cell anemia
1,213 Tanzanian ancestry cases
321 Afro-Caribbean and Sub-Saharan African cases
226 Japanese ancestry cases, 186 Japanese ancestry controls
423 type 2 diabetes cases and 127 unaffected siblings from 257 families
1,656 Han Chinese ancestry cases, 3,394 Han Chinese ancestry controls
3,256 Han Chinese ancestry cases, 5,667 Han Chinese ancestry controls, 453 Thai ancestry cases, 963 Thai ancestry controls
702 European ancestry genetic absence epilepsies cases, 586 European ancestry juvenile myoclonic epilepsy cases, 239 European ancestry other genetic generalized epilepsies cases, 2,461 European ancestry controls
347 European ancestry genetic absence epilepsies trios, 166 European ancestry juvenile myoclonic epilepsy trios, 91 European ancestry other genetic generalized epilepsies trios, 385 European ancestry genetic absence epilepsies cases, 382 European ancestry juvenile myoclonic epilepsy cases, 122 European ancestry other genetic generalized epilepsies cases, up to 889 European ancestry controls
Apolipoprotein Levels
1,720 European ancestry monozygotic twins
Cholesterol and Triglycerides
1,261 European ancestry monozygotic twins
Exfoliation glaucoma or exfoliation syndrome
201 Japanese ancestry cases, 697 Japanese ancestry controls
121 Japanese ancestry cases, 263 Japanese ancestry controls
5,483 European ancestry type 2 diabetes cases, 5,174 European ancestry controls
19,424 European ancestry adult individuals, 10,172 European ancestry children
13,708 European ancestry cases, 95,282 European ancestry controls
5,353 European ancestry cases, 5,551 European ancestry controls
124 Old Order Amish cases, 295 Old Order Amish controls
1,555 European ancestry cases, 1,467 European ancestry controls, 300 Pima Indian ancestry cases, 334 Pima Indian ancestry controls, 287 Mexican American cases, 316 Mexican American controls
Non-alcoholic fatty liver disease histology (other)
126 European ancestry adolescent cases, 802 European ancestry adolescent controls
PCA3 expression level
1,371 European ancestry individuals
2,383 European ancestry adolescents and 1,643 European ancestry adults from 1,613 families
Longevity (90 years and older)
5,406 European ancestry cases, 15,112 European ancestry controls
7,330 European ancestry cases, 61,156 European ancestry controls
Longevity (85 years and older)
7,729 European ancestry cases, 16,121 European ancestry controls
13,060 European ancestry cases, 61,156 European ancestry controls
Restless legs syndrome
628 European ancestry cases, 1,644 European ancestry controls
1,550 European ancestry cases, 2,269 European ancestry controls, 285 French Canadian founder cases, 842 French Canadian founder controls
Hearing function
1,022 European ancestry individuals, 280 Carlantino (founder/genetic isolate) individuals, 1,097 Friuli Venezia Giulia (founder/genetic isolate) individuals, 804 Korcula (founder/genetic isolate) individuals, 497 Split (founder/genetic isolate) individuals, 421 Cilento (founder/genetic isolate) individuals, 470 Talana (founder/genetic isolate) individuals, 348 Silk Road individuals
Affymetrix, Illumina [> 2300000] (imputed)
Obesity-related traits
4,741 Sardinian individuals
3,205 African American, Hispanic, and European ancestry individuals
Response to thiazide diuretic treatment (hypokalemia)
425 European ancestry hypertensive individuals, 342 African American hypertensive individuals
Nicotine use
7,188 European ancestry individuals
Illicit drug use
Non-substance related behavioral disinhibition
Behavioural disinhibition (generation interaction)
3,852 European ancestry parents, 3,336 European ancestry offspring
Pulse pressure (alcohol consumption interaction)
up to 6,882 individuals
Systolic blood pressure (alcohol consumption interaction)
up to 6,882 European ancestry individuals
Diastolic blood pressure (alcohol consumption interaction)
Mean arterial pressure (alcohol consumption interaction)
7,626 Korean ancestry individuals
903 Korean ancestry individuals
Coronary heart disease in familial hypercholesterolemia
249 European ancestry cases, 217 European ancestry controls
744 European ancestry cases, 1,691 European ancestry controls
301 Sri Lankan Sinhalese ancestry cases, 276 Sri Lankan Sinhalese ancestry controls
8,830 Han Chinese ancestry individuals
Affymetrix, Illumina [up to 2249917] (imputed)
Anger
8,747 European ancestry individuals
1,031 Han Chinese ancestry cases, 1,031 Han Chinese ancestry controls
1,860 Han Chinese ancestry cases, 3,660 Han Chinese ancestry controls
Medication adherence in chronic diseases
155 Korean ancestry medication non-adherent diabetes cases, 80 Korean ancestry medication non-adherent hypertensive cases, 240 Korean ancestry medication adherent diabetes cases, 827 Korean ancestry medication adherent hypertensive cases
1,497 Latino cases, 3,213 Latino controls
1,643 Latino cases, 4,971 Latino controls
Affymetrix, Illumina [7229558] (imputed)
3,310 Japanese ancestry individuals
1,625 European ancestry females
1,165 European ancestry individuals
17,290 East Asian ancestry individuals, 1,727 Malay ancestry individuals
up to 13,585 East Asian ancestry individuals
Affymetrix, Illumina [up to 2400000] (imputed)
Urinary bladder cancer
1,670 European ancestry cases, 90,180 European ancestry controls
5,241 European ancestry cases, 10,456 European ancestry controls
Preschool internalizing problems
3,121 European ancestry individuals, 1,475 children from 1,031 families
Affymetrix, Illumina [2403520] (imputed)
Red blood cell traits
1,664 Val Borbera (founder/genetic isolate) individuals
619 Friuli Venezia Giulia (founder/genetic isolate) individuals, 16,145 European ancestry individuals
Osteoarthritis (hand, severe)
623 European ancestry cases, 69,153 European ancestry controls
214 European ancestry cases, 8,172 European ancestry controls
664 European ancestry lobar cases, 881 European ancestry nonlobar cases, 1,481 European ancestry controls
513 European ancestry cases, 634 African American cases, 534 Hispanic cases, 1,552 European ancestry controls, 449 African American controls, 260 Hispanic controls
Affymetrix, Illumina [5258103] (imputed)
656 European ancestry individuals
Up to 3,282 European ancestry individuals
105 European ancestry cases, 34 Hispanic cases, 26 African American cases, 22 cases
549 Caribbean Hispanic cases, 544 Caribbean Hispanic controls
3,839 European ancestry individuals, 116 Caribbean Hispanic cases, 70 Caribbean Hispanic controls
Sickle cell anemia (severity)
177 African American severe cases, 1,088 African American mild cases
68 African American severe cases, 95 African American mild cases
9,747 European ancestry cases, 14,278 European ancestry controls
4,694 Sardinian individuals
1,392 Sardinian individuals
18,963 European ancestry individuals, 2,131 Erasmus Rucphen individuals
2,453 Chinese ancestry individuals, 2,026 Indian ancestry individuals, 2,305 Malay ancestry individuals
Inflammatory biomarkers in Kawasaki disease
178 Korean ancestry cases
473 Korean ancestry cases
Amyloid A serum levels
3,329 European ancestry individuals, 882 Sorbian (founder/genetic isolate) individuals
2,136 European ancestry individuals
Affymetrix, Illumina [2593456] (imputed)
HDL cholesterol (SNP x SNP interaction)
2,996 European ancestry indivdiuals
2,755 Erasmus Rucphen individuals, 12,276 European ancestry individuals, 18,203 individuals
Thyroid peroxidase antibody positivity
1,769 European ancestry cases, 16,528 European ancestry controls
922 European ancestry cases, 8,068 European ancestry controls
Affymetrix, Illumina [up to 3437411] (imputed)
Thyroid peroxidase antibody levels
12,353 European ancestry individuals
8,159 European ancestry individuals
464 African American cases, 471 African American controls, 355 African Caribbean ancestry cases and 574 African Caribbean ancestry controls from 163 families
994 European ancestry cases, 1,243 European ancestry controls, 2,331 African American cases, 2,874 African American controls
658 African American prevalent cases, 1,062 African American incident cases, 6,067 African American controls, 153 Hispanic prevalent cases, 336 Hispanic incident cases, 2,685 Hispanic controls
Immune response to measles-mumps-rubella vaccine
883 European ancestry individuals
Kashin-Beck disease
90 Han Chinese ancestry cases, 1,627 Han Chinese ancestry controls
559 Han Chinese ancestry cases, 467 Han Chinese ancestry controls
Lupus nephritis in systemic lupus erythematosus
588 European ancestry cases, 1,412 European ancestry controls
Affymetrix, Illumina [1621689] (imputed)
Methotrexate phramacokinetics (acute lymphoblastic leukemia)
315 European ancestry cases, 73 African American cases, 5 Asian ancestry cases, 247 cases
Methotrexate clearance (acute lymphoblastic leukemia)
22 East Asian ancestry cases, 58 African ancestry, African American or Afro-Caribbean cases, 266 Hispanic or Latin American cases, 806 European ancestry cases, 127 cases
699 European ancestry cases
Blood metabolite ratios
Up to 5,591 European ancestry individuals
Up to 1,767 European ancestry individuals
Affymetrix, Illumina [2100000] (imputed)
7,824 European ancestry individuals
Response to inhaled corticosteroid treatment in asthma (change in FEV1)
189 Korean ancestry cases
up to 4,734 European ancestry cases, up to 46,903 European ancestry controls
up to 6,928 European ancestry cases, up to 20,570 European ancestry controls
657 European ancestry cases, 9,296 European ancestry controls
1,641 European ancestry cases, 1,604 European ancestry controls
740 European ancestry cases, 1,501 European ancestry controls
up to 2,695 European ancestry cases, up to 2,777 European ancestry controls
up to 3,235 cases, up to 12,059 controls
2,695 European ancestry cases, 2,777 European ancestry controls
2,261 cases, 3,357 controls
3,427 Chinese ancestry individuals, 1,735 Malay ancestry individuals, 1,520 Asian Indian ancestry individuals
Antinuclear antibody levels
3,185 Japanese ancestry individuals
3,963 Japanese ancestry individuals
470 European ancestry individuals from 99 families
295 individuals, 247 Black individuals from 105 families
Personality traits in bipolar disorder
1,951 European ancestry cases
Response to chemotherapy in multiple myeloma (oral mucositis) (high-dose melphalan)
619 European ancestry cases with grades 0-1 oral mucositis, 353 European ancestry cases with grades 2-4 oral mucositis
Openness
17,375 European ancestry individuals
3,294 European ancestry individuals
Conscientiousness
Agreeableness
Response to antipsychotic therapy (extrapyramidal side effects)
421 European ancestry schizophrenia cases, 214 African American schizophrenia cases, 103 schizophrenia cases
5,765 European ancestry individuals, 890 African American individuals
255 African American cases, 375 African American controls
140 African American cases, 543 African American controls
Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced)
112 European ancestry cases, 124 European ancestry controls, 120 Han Chinese ancestry cases, 101 Han Chinese ancestry controls
Hepatic lipid content in extreme obesity
1,868 European ancestry cases
Bilirubin levels in extreme obesity
Drug-induced torsades de pointes
216 European ancestry cases, 386 European ancestry drug-exposed controls, 385 European ancestry population controls
Obsessive-compulsive disorder
1,406 cases and 1,489 controls from 1,065 families, 192 cases, 1,984 controls
Interferon alpha levels in systemic lupus erythematosus
88 European ancestry high interferon alpha cases, 322 European ancestry low interferon alpha cases
715 European ancestry cases, 450 African American cases
Hypospadias
1,006 European ancestry male child cases, 2,390 European ancestry male child controls, 3,096 European ancestry female child controls
1,972 European ancestry male child cases, 1,401 European ancestry male child controls, 405 European ancestry female child controls, 6 European ancestry child controls
603 European ancestry cases, 3,637 European ancestry controls
333 European ancestry cases, 675 European ancestry controls
Breastfeeding duration
1,521 mothers from 1,073 families
Naphthyl-keratin adduct levels
100 European, Hispanic, African American and Asian ancestry individuals
2,078 European ancestry cases, 2,953 European ancestry controls
19,350 European ancestry cases, 35,408 European ancestry controls
47,180 European ancestry individuals
4,771 African American individuals
3,412 European ancestry individuals
3,389 European ancestry individuals
645 European ancestry age 6 individuals, 28 age 6 individuals, 1,073 European ancestry age 14 individuals, 67 age 14 individuals
278 American Indian ancestry young-onset cases, 129 American Indian ancestry cases, 424 American Indian ancestry controls from 514 sibships
1,273 American Indian ancestry cases, 1,635 American Indian ancestry controls, 793 cases, 3,133 controls
Alcohol dependence (age at onset)
685 European ancestry cases, 1,103 European ancestry controls from 118 families
572 European ancestry cases, 888 European ancestry controls
Up to 1,761 European ancestry cases, 3,727 European ancestry controls
1,346 Han Chinese ancestry individuals
3,235 She Chinese ancestry individuals
597 Han Chinese ancestry individuals
2,955 Han Chinese ancestry individuals
5,833 European ancestry females, 2,639 European ancestry males, 784 Han Chinese ancestry females, 763 Han Chinese ancestry males, 712 African American females, 409 Hispanic females
7,010 European ancestry females, 3,772 European ancestry males, 2,980 East Asian ancestry females, 2,159 East Asian ancestry males
Affymetrix, Illumina [5842825] (imputed)
Hyperopia
7,068 European ancestry cases, 6,844 European ancestry controls
1,554 European ancestry cases, 892 cases, 1,654 European ancestry controls, 2,921 controls
Affymetrix, Illumina [up to 3397980] (imputed)
Myopia
3,923 European ancestry cases, 11,696 European ancestry controls
1,410 European ancestry cases, 2,921 cases, 3,171 European ancestry controls, 998 controls
Plasma amyloid beta peptide concentrations (ABx-40)
3,528 European ancestry individuals
Plasma amyloid beta peptide concentrations (ABx-42)
485 Ashkenazi Jewish cases, 498 Ashkenazi Jewish controls, 1,977 European ancestry cases, 999 European ancestry controls
1,131 Ashkenazi Jewish cases, 831 Ashkenazi Jewish controls
Serologic markers in systemic lupus erythematosus
44 European, African American, Hispanic American, and Asian American high IFN-alpha cases, 60 European, African American, Hispanic American, and Asian American low IFN-alpha cases
280 African American cases, 173 European ancestry cases, 85 Hispanic American cases
1,399 European ancestry cases, 5,275 European ancestry controls
2,174 European ancestry cases, 7,287 European ancestry controls
2,098 East Asian ancestry cases, 6,172 East Asian ancestry controls
12,865 East Asian ancestry cases, 25,773 East Asian ancestry controls, up to 16,984 European ancestry cases, up to 18,262 European ancestry controls
Affymetrix, Illumina [2400000] (imputed)
Non-small cell lung cancer (recurrence rate)
250 Korean ancestry cases
308 Korean ancestry cases
Musical aptitude
767 European ancestry individuals from 76 families
up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Affymetrix, Illumina [up to 9739303] (imputed)
1,848 European ancestry affected individuals, 1,991 European ancestry unaffected individuals
231 Caribbean Hispanic cases, 187 Caribbean Hispanic controls, 386 European ancestry cases, 386 European ancestry controls
Response to TNF-alpha inhibitors in rheumatoid arthritis
882 European ancestry cases
1,821 European ancestry cases
91,323 European ancestry individuals
8,423 African American individuals, 1,447 Hispanic individuals
Affymetrix, Illumina [2515567] (imputed)
Autism
275 Chinese ancestry cases and 550 Chinese ancestry controls from 275 trios, 136 Chinese ancestry cases, 984 Chinese ancestry controls
1,299 European ancestry cases and 2,598 European ancestry controls from 1,299 trios
Glycemic traits (pregnancy)
1,367 European ancestry individuals, 817 Hispanic individuals, 1,075 Afro-Caribbean individuals, 1,178 Thai ancestry individuals
2,798 European ancestry individuals, 228 French Canadian founder population individuals
Thrombin generation potential phenotypes
714 European ancestry venous thrombosis cases, 1,253 European ancestry individuals
714 European ancestry venous thrombosis cases, 543 European ancestry individuals
Smoking quantity
1,837 Bangladeshi ancestry males, 198 Bangladeshi ancestry females
Smoking initiation
754 Bangladeshi ancestry never smoker males, 2,565 Bangladeshi ancestry never smoker females, 1,837 Bangladeshi ancestry ever smoker males, 198 Bangladeshi ancestry ever smoker females
Smoking cessation
366 Bangladeshi ancestry former smoker males, 87 Bangladeshi ancestry former smoker females, 1,471 Bangladeshi ancestry current smoker males, 111 Bangladeshi ancestry current smoker females
Hemoglobin A2 levels in sickle cell anemia
618 African American cases
173 African American cases, 398 Chinese ancestry individuals
Osteoarthritis biomarkers
up to 4,654 European ancestry individuals
964 European ancestry individuals
Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry)
820 African American cases
4,568 European ancestry cases
11,816 Han Chinese ancestry individuals
69,146 Han Chinese ancestry individuals
Affymetrix, Illumina [2485448] (imputed)
5,065 Han Chinese ancestry cases, 4,404 Han Chinese ancestry controls
29,799 Han Chinese ancestry cases, 39,347 Han Chinese ancestry controls
75 European, Asian, African American, and Hispanic ancestry Ph-like ALL cases, 436 European, Asian, African American, and Hispanic ancestry non Ph-like ALL cases, 6,661 European, Asian, African American, and Hispanic ancestry non-ALL controls
32 European, Asian, African American, and Hispanic ancestry Ph-like ALL cases, 139 European, Asian, African American, and Hispanic ancestry non Ph-like ALL cases, 3,647 European ancestry non-ALL controls, 1,228 African American non-ALL controls, 920 Hispanic non-ALL controls, 25 Native American non-ALL controls
Birth length
28,459 European ancestry individuals
16,145 European ancestry individuals, 280 Moroccan ancestry individuals, 284 Surinamese ancestry individuals, 319 Turkish ancestry individuals, 651 Chinese ancestry individuals
Affymetrix, Illumina [2201971] (imputed)
Infant length
28,238 European ancestry individuals
Affymetrix, Illumina [2193675] (imputed)
1,893 European ancestry cases, 5,132 European ancestry controls
2,063 European ancestry cases, 1,970 European ancestry controls
Cystic fibrosis severity
160 European ancestry severe lung disease cases, European ancestry 160 mild lung disease cases
485 European ancestry cases,91 controls, 2,194 individuals
1,489 European ancestry individuals
Age-related hearing impairment (SNP x SNP interaction)
660 Ashkenazi Jewish cases, 2,271 Ashkenazi Jewish controls
1,859 European ancestry cases, 3,943 European ancestry controls, 759 Ashkenazi Jewish cases, 3,389 Ashkenazi Jewish controls, 415 Han Chinese ancestry cases, 458 Han Chinese ancestry controls
242 European ancestry cases, 242 European ancestry controls
553 European ancestry cases, 1,033 European ancestry controls
694 individuals from 288 families
3,213 European ancestry obese cases, 6,210 European ancestry non-obese controls, 229 individuals, 368 European ancestry trios, 361 African American obese cases, 505 African American non-obese controls
Response to statin therapy
85 European ancestry cases, 90 European ancestry controls
21 European ancestry cases, 16,643 European ancestry controls
Amyotrophic lateral sclerosis or frontotemporal dementia
4,377 European ancestry ALS cases, 435 European ancestry FTD cases, 14,431 European ancestry controls
4,056 European ancestry ALS cases, 3,958 European ancestry controls
435 European ancestry cases, 1,414 European ancestry controls
4,377 European ancestry cases, 13,017 European ancestry controls
Vitiligo
1,392 European ancestry cases, 2,629 European ancestry controls
647 European ancestry cases, 1,056 European ancestry controls, 183 European ancestry trios, 1,383 European ancestry individuals from 332 families
717 European ancestry cases, 2,385 European ancestry controls
1,963 European ancestry cases, 5,801 European ancestry controls, 24 Erasmus Rucphen cases, 28 Erasmus Rucphen controls
Response to diuretic therapy in hypertension
424 European ancestry individuals
841 European ancestry individuals
1,524 European ancestry female individuals from 762 sibships
669 African American female individuals from 383 sibships
Bipolar disorder (body mass index interaction)
388 European ancestry cases, 1,020 European ancestry controls
2,617 European ancestry cases, 2,548 European ancestry controls
1,516 European ancestry cases, 5,321 European ancestry controls
Pneumoconiosis in silica exposure
202 Han Chinese ancestry cases, 198 Han Chinese ancestry controls
490 Han Chinese ancestry cases, 541 Han Chinese ancestry controls
Iron status biomarkers
2,347 African American individuals
329 African American individuals
94 Costa Rican founder population smoker cases, 412 Costa Rican founder population smoker controls, 63 Hispanic ancestry cases, 619 Hispanic ancestry controls
47 Hispanic ancestry smoker cases, 290 Hispanic ancestry smoker controls
2,789 Korean ancestry individuals
829 Korean ancestry individuals
377 Korean ancestry cases, 3,019 Korean ancestry anti-TPO controls
108 Korean ancestry cases, 734 Korean ancestry controls
1,173 European ancestry cases, 2,511 European ancestry controls
395 European ancestry cases, 2,663 European ancestry controls, 63 Turkish, Surinamese, Dutch Antillean, Moroccan, Cape Verdian and other ancestry cases, 917 Turkish, Surinamese, Dutch Antillean, Moroccan, Cape Verdian and other ancestry controls, 6,783 cases, 7,720 controls
Pulmonary emphysema
2,587 European ancestry individuals, 2,510 African American individuals, 2,113 Hispanic individuals, 704 Chinese ancestry individuals
6,023 European ancestry individuals
Hypertension (young onset)
400 Han Chinese ancestry cases, 400 Han Chinese ancestry controls
592 Han Chinese ancestry cases, 592 Han Chinese ancestry controls, 315 Han Chinese ancestry individuals from 111 families, 1,999 European ancestry cases, 3,004 European ancestry controls
Response to interferon beta therapy
99 European ancestry responders, 107 European ancestry non-responders
81 European ancestry individuals
Enteric fever
432 Vietnamese ancestry cases, 2,011 Vietnamese ancestry controls
151 Vietnamese ancestry cases, 668 Vietnamese ancestry controls, 595 Nepalese ancestry cases, 386 Nepalese ancestry controls
4,158 European ancestry males, 531 South Tyrol males, 4,253 European ancestry females, 692 South Tyrol females, 702 Han Chinese ancestry females
Affymetrix, Illumina [up to 2544063] (imputed)
1,146 European ancestry cases, 1,804 European ancestry controls
1,854 European ancestry cases, 1,437 European ancestry controls
7,100 European ancestry individuals
Cerebrospinal fluid levels of Alzheimer's disease-related proteins
574 individuals
725 European ancestry cases, 2,438 European ancestry controls
661 European ancestry cases, 614 European ancestry controls
2,617 European ancestry cases, 2,894 European ancestry controls
Bronchodilator response in asthma (inhaled corticosteroid treatment interaction)
172 European ancestry cases, 409 European ancestry controls
227 European ancestry cases
Response to antiplatelet therapy
565 European ancestry individuals
710 European ancestry individuals, 237 African American individuals, 276 Hispanic individuals, 4 individuals
Breast cancer (menopausal hormone therapy interaction)
2,920 European ancestry cases
7,689 European ancestry cases, 9,266 European ancestry controls
Lobular breast cancer (menopausal hormone therapy interaction)
541 European ancestry cases
676 European ancestry cases, 9,266 European ancestry controls
3,848 Mexican and other Latin American ancestry cases, 4,366 Mexican and other Latin American ancestry controls
896 Mexican American cases, 832 Mexican American controls, 2,768 East Asian ancestry cases, 2,880 East Asian ancestry controls, 1,082 South Asian ancestry cases, 1,105 South Asian ancestry controls, 1,874 European ancestry cases, 1,333 European ancestry controls, 2,127 African American cases, 2,103 African American controls, 698 Native Hawaiian ancestry cases, 579 Native Hawaiian ancestry controls, 2,009 Singaporean ancestry cases, 1959 Singaporean ancestry controls
1,020 European ancestry cases, 1,636 European ancestry controls
Sleep-related phenotypes
up to 738 individuals from 203 families
Cardiovascular event reduction in the elderly at risk for vascular disease (statin therapy interaction)
5,244 individuals
1,233 cases
2,371 European ancestry cases, 35,909 European ancestry controls
4,338 European ancestry cases, 8,530 European ancestry controls, 1,183 East Asian ancestry cases, 1,245 East Asian ancestry controls
Affymetrix, Illumina [2335627] (imputed)
1,001 European ancestry cases, 2,371 European ancestry controls
925 European ancestry cases, 1,621 European ancestry controls, 738 cases, 697 controls
1,452 Han Chinese ancestry individuals
Body mass index (education interaction)
816 non-college graduate individuals, 1,061 college graduate individuals
1,173 individuals
Reading disability or specific language impairment (pleiotropy)
548 children from 288 families, 749 children from 343 unrelated twinships/sibliships, 959 children
Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy)
1,826 children
3,550 European ancestry cases, 8,888 European ancestry controls
694 European ancestry cases, 4,375 European ancestry controls, 1,343 cases, 5,352 controls
127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals
130,795 European ancestry individuals
Brain activation in response to working memory task
679 European ancestry individuals
97 unknown ancestry individuals
Attention function
1,655 European ancestry children
546 European ancestry children
Diabetes in response to antihypertensive drug treatment (treatment strategy interaction)
138 European American hypertensive cases with diabetes, 414 European American hypertensive cases without diabetes
157 Hispanic hypertensive cases with diabetes, 314 Hispanic hypertensive cases without diabetes, 39 African American hypertensive cases with diabetes, 78 African American hypertensive cases without diabetes
Emphysema distribution in smoking
7,039 European ancestry individuals, 2,955 African American individuals, 1538 individuals
484 Korean ancestry children
10,390 Korean ancestry individuals
399 diabetes cases, 107 non-diabetes controls from 240 families
448 Japanese ancestry individuals
4,059 Japanese ancestry individuals
22,814 East Asian ancestry individuals
57,490 East Asian ancestry individuals
Affymetrix, Illumina [~ 2400000] (imputed)
32,285 East Asian ancestry individuals, 173,082 European ancestry individuals
8,478 Chinese ancestry individuals
Affymetrix, Illumina [~ 1900000] (imputed)
25,169 East Asian ancestry individuals
45,953 East Asian ancestry individuals
32,576 East Asian ancestry individuals, 187,365 European ancestry individuals
10,855 Chinese ancestry individuals
Affymetrix, Illumina [up to 1900000] (imputed)
22,526 East Asian ancestry individuals
37,842 East Asian ancestry individuals
28,183 East Asian ancestry individuals, 177,861 European ancestry individuals
10,857 Chinese ancestry individuals
18,421 East Asian ancestry individuals
38,060 East Asian ancestry individuals
34,930 East Asian ancestry individuals, 187,167 European ancestry individuals
8,741 Chinese ancestry individuals
17,666 children
Affymetrix, Illumina [at least 5260671] (imputed)
59,565 European ancestry individuals, 690 Orcadian (founder/genetic isolate) individuals
13,263 European ancestry individuals, 3,603 African American individuals, 4,619 Indian ancestry individuals
Affymetrix, Illumina, Perlegen [at least 2766983] (imputed)
QRS complex (12-leadsum)
up to 47,942 European ancestry individuals, up to 690 Orcadian (founder/genetic isolate) individuals
Affymetrix, Illumina, Perlegen [2766983] (imputed)
QRS complex (Cornell)
up to 58,172 European ancestry individuals, up to 690 Orcadian (founder/genetic isolate) individuals
QRS complex (Sokolow-Lyon)
up to 54,303 European ancestry individuals, up to 690 Orcadian (founder/genetic isolate) individuals
Essential tremor
1,778 European ancestry cases, 5,376 European ancestry controls
1,029 European ancestry cases, 1,065 European ancestry controls
Emotional dysregulation
774 African American males, 1,826 African American females
5,458 Caribbean Hispanic/Latino individuals, 6,734 Mainland Hispanic/Latino individuals, 34 Hispanic/Latino individuals
Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes
729 European ancestry cases, 84 cases, 3,290 European ancestry controls, 705 controls
94 European ancestry cases, 964 cases, 993 European ancestry controls, 4806 controls
Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes
729 European ancestry cases, 84 cases, 1,903 European ancestry controls, 491 controls
94 European ancestry cases, 964 cases, 627 European ancestry controls, 3187 controls
Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes
907 European ancestry cases, 210 cases, 1,661 European ancestry controls, 357 controls
1,266 cases, 2,655 controls
Kidney disease (early and late stages) in type 1 diabetes
2,068 European ancestry cases, 495 cases, 1,903 European ancestry controls, 690 controls
68 European ancestry cases, 3,188 cases, 815 European ancestry controls, 3,907 controls
Kidney disease (early stage) in type 1 diabetes
555 European ancestry cases, 245 cases, 1,903 European ancestry controls, 690 controls
602 cases, 1,459 controls
Kidney disease (late stage) in type 1 diabetes
1,507 European ancestry cases, 250 controls, 1,903 European ancestry controls, 690 controls
2,536 cases, 3,907 controls
Chronic kidney disease (chronic kidney disease vs normal or mildly reduced eGFR) in type 1 diabetes
1,142 European ancestry cases, 113 cases, 2,442 European ancestry controls, 467 controls
2,046 cases, 4,549 controls
Hepatitis B (viral clearance)
27 Asian ancestry delayed seroconversion cases, 30 Asian ancestry spontaneously recovered controls
192 Asian ancestry delayed seroconversion cases, 110 Asian ancestry spontaneously recovered controls
up to 29,946 European ancestry individuals, up to 6150 African American individuals, 15,074 East Asian individuals.
16,389 individuals of European and African American ancestry.
up to 40,258 European ancestry individuals, 16,128 African American individuals, up to 15,252 East Asian ancestry individuals.
16,389 European and African American individuals
up to 21,020 European ancestry individuals, up to 3,621 African American individuals, up to 15,062 East Asian individuals.
up to 40,258 European ancestry individuals, up to 16,128 African American individuals, up to 15,252 East Asian individuals.
up to 40,258 European ancestry individuals, up to 16,128 African American individuals, up to 15,252 East Asian ancestry individuals.
353 Polish ancestry child cases, 237 Polish ancestry adult cases, 582 Polish ancestry controls
71 Polish ancestry child cases, 100 Polish ancestry adult cases, 352 Polish ancestry controls
269 Polish ancestry child cases, 259 Polish ancestry adult cases, 582 Polish ancestry controls
121 Polish ancestry child cases, 85 Polish ancestry adult cases, 352 Polish ancestry controls
622 Polish ancestry child cases, 496 Polish ancestry adult cases, 582 Polish ancestry controls
192 Polish ancestry child cases, 185 Polish ancestry adult cases, 352 Polish ancestry controls
Glomerular load of uric acid
768 Hispanic children from 260 families
Uric acid clearance
Fractional excretion of uric acid
Creatinine clearance
Urinary uric acid to urinary creatinine ratio
Bortezomib-induced peripheral neuropathy in multiple myeloma
102 European ancestry cases and 544 European ancestry controls.
Whole body bone mineral density and alcohol drinking
506 European ancestry males, 1,553 European ancestry females
Hip bone mineral density and alcohol drinking
Spine bone mineral density and alcohol drinking
Adiponectin levels in pregnancy
522 European ancestry individuals, 174 French Canadian founder individuals
Clopidogrel active metabolite levels
513 Amish individuals
Response to clopidogrel therapy
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy)
8,726 European ancestry ankylosing spondylitis cases, 19,085 European ancestry Crohn’s disease cases, 6,530 European ancestry psoriasis cases, 3,408 European ancestry primary sclerosing cholangitis cases, 14,513 European ancestry ulcerative colitis cases, 34,213 European ancestry controls
Carotid plaque burden
7,189 European ancestry individuals
Osteoarthritis (with total hip replacement)
3,110 Icelandic ancestry cases, 1,547 non-array typed, familial imputed Icelandic ancestry cases, 99,911 Icelandic ancestry controls, 107,603 non-array typed, familial imputed Icelandic ancestry controls
Hepcidin/transferrin saturation ratio
1495 European ancestry individuals without iron deficiency or clinical inflammation, 324 European ancestry individuals, 1206 Val Borbera (founder/genetic isolated) individuals without iron deficiency or clinical inflammation, 274 Val Borbera (founder/genetic isolated) individuals, 2,695 European ancestry individuals without iron deficiency or clinical inflammation, 207 individuals
Hepcidin/ferritin ratio
Hepcidin levels
1,018 European ancestry individuals, 2,876 individuals
9,619 European ancestry cases, 324,522 European ancestry controls
33,790 European ancestry individuals
Migraine
53,109 European ancestry cases, 230,876 European ancestry controls
28,399 European ancestry cases, 128,843 European ancestry controls
Hypothyroidism
17,558 European ancestry cases, 117,083 European ancestry controls
Chin dimples
58,032 European ancestry cases, 13,457 European ancestry controls
Allergy
66,973 European ancestry cases, 113,768 European ancestry controls
Childhood ear infection
46,936 European ancestry cases, 74,874 European ancestry controls
32,446 European ancestry cases, 67,249 European ancestry controls
76,831 European ancestry individuals
Age at voice drop
55,871 European ancestry individuals
60,098 European ancestry cases, 113,323 European ancestry controls
Monobrow
69,284 European ancestry individuals
106,086 European ancestry cases, 85,757 European ancestry controls
Joint mobility (Beighton score)
64,143 European ancestry individuals
Nose size
67,023 European ancestry individuals
9,009 European ancestry cases, 8,491 European ancestry controls
Gut microbiota (beta diversity)
1,812 European ancestry individuals
371 European ancestry individuals
Affymetrix, Illumina [6344846] (imputed)
Gut microbiota (bacterial taxa)
Exhaled nitric oxide output
229 European ancestry infants
Exhaled nitric oxide levels
Phlegm
7,976 Dutch ancestry individuals
6,789 Dutch ancestry individuals
Dyspnea
Cough
Response to paliperidone in schizophrenia (positive Marder score)
1,390 European ancestry cases
Response to paliperidone in schizophrenia (negative Marder score)
Response to paliperidone in schizophrenia (PANSS score)
1,390 European ancestry individuals
Response to paliperidone in schizophrenia (Multivariate)
Response to paliperidone in schizophrenia (CGI-S score)
Cleft palate
272 Asian ancestry case-parent trios, 161 Asian ancestry controls, 38 European ancestry cases, 296 European ancestry case-parent trios, 835 European ancestry controls, 40 Latino or African cases, 34 Latino or African case-parent trios, 704 Latino or African controls, 14 case-parent trios.
Orofacial clefts
83 Asian ancestry cases, 1,445 Asian ancestry case-parent trios, 161 Asian ancestry controls, 208 European ancestry cases, 1,284 European ancestry case-parent trios, 835 European ancestry controls, 610 Latino or African cases, 663 Latino or African case-parent trios, 704 Latino or African controls, 35 case-parent trios.
83 Asian ancestry cases, 1,173 Asian ancestry case-parent trios, 161 Asian ancestry controls,170 European ancestry cases, 988 European ancestry case-parent trios, 835 European ancestry controls, 570 Latino or African cases, 629 Latino or African case-parent trios, 704 Latino or African controls, 21 case-parent trios.
QT interval (tricyclic/tetracyclic antidepressant use interaction)
1,250 European ancestry users, 295 African American users, 1,886 Hispanic or Latino ancestry users, 40,701 European ancestry non-users, 9,940 African American non-users, 67,863 Hispanic or Latino ancestry non-users
RR interval (tricyclic/tetracyclic antidepressant use interaction)
1,417 European ancestry users, 295 African American users, 174 Hispanic or Latino ancestry users, 44,289 European ancestry non-users, 9,940 African American non-users, 13,634 Hispanic or Latino ancestry non-users
68 Han Chinese ancestry cases, 84 Han Chinese controls.
199 Han Chinese ancestry cases, 304 Han Chinese controls.
Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder
up to 780 Han Chinese ancestry child or adolescent individuals
up to 922 Han Chinese ancestry child or adolescent individuals
Systolic blood pressure (long-term average)
18,422 East Asian ancestry individuals
up to 46,629 European ancestry individuals
Diastolic blood pressure (long-term average)
Pulse pressure (long-term average)
Mean arterial pressure (long-term average)
3,120 Japanese ancestry cases, 125,064 Japanese ancestry controls, 15,993 European ancestry cases, 113,719 European ancestry controls
Peak velocity of the mitral E-wave
21,852 European ancestry individuals
14,787 European ancestry individuals
Affymetrix, Illumina [at least 283291] (imputed)
Isovolumetric relaxation time
Peak velocity of excursion of lateral mitral annulus in early diastolic phase
Peak velocity of the mitral A-wave
Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.
Deceleration time of the mitral E-wave
Ratio of the peak velocity of the excursion of the lateral mitral annulus in the early diastolic phase and the peak velocity of the mitral E-wave
Diastolic dysfunction with preserved ejection pressure
Heart failure with preserved ejection fraction
Aortic root size
30,201 European ancestry individuals
14,002 European ancestry individuals
Left atrial antero-posterior diameter
Left ventricle diastolic internal dimension
Left ventricular fractional shortening
Left ventricle systolic dysfunction
Nicotine metabolite ratio
49 African American ancestry individuals, 51 Asian American ancestry individuals, 215 European American individuals
Urinary 1,3-butadiene metabolite levels in smokers
327 African American individuals, 349 Japanese American individuals, 396 European ancestry individuals
Immune response to measles vaccine (measles-specific neutralising antibody titre)
2,555 European ancestry individuals, 317 African American individuals
Immune response to measles vaccine (measles-induced IFN gamma)
up to 2,555 European ancestry individuals, up to 317 African American individuals
1,570 West African individuals
1,411 West African individuals, 9,020 African American individuals
9,179 European ancestry individuals
320 Japanese ancestry individuals
439 Japanese ancestry individuals
Depressive symptoms (stressful life events interaction)
Gut microbiota (functional units)
984 European ancestry individuals
530 European ancestry individuals
285 Puerto Rican individuals
373 African American individuals
Palmitoleic acid (16:1n-7) levels
3,521 Chinese ancestry individuals, European individuals (see Wu 2013).
Affymetrix, Illumina [~ 2200000] (imputed)
Vaccenic acid (18:1n-7) levels
3,521 Chinese ancestry individuals, 12,020 European ancestry individuals
Affymetrix, Illumina [2200000] (imputed)
Oleic acid (18:1n-9) levels
3,521 Chinese ancestry individuals, European ancestry individuals (see Wu et al 2013)
Gondoic acid (20:1n-9) levels
Erucic acid (22:1n-9) levels
Nervonic acid (24:1n-9) levels
Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase
324 European ancestry cases and 3258 European ancestry controls.
54 European ancestry cases and 1465 European ancestry controls.
Vasculitis associated with antineutrophil cytoplasmic antibody reactive to proteinase-3
882 European ancestry cases and 3258 European ancestry controls.
479 European ancestry cases and 1465 European ancestry controls.
Antineutrophil cytoplasmic antibody-associated vasculitis
1,015 European ancestry granulomatosis with polyangiitis cases, 206 European ancestry microscopic polyangiitis cases, 3,258 European ancestry controls.
541 European ancestry granulomatosis with polyangiitis cases, 30 European ancestry microscopic polyangiitis cases, 1,465 European ancestry controls.
Age-related diseases and mortality
9,618 European ancestry individuals
19,796 European ancestry individuals
Age-related diseases, mortality and associated endophenotypes
Age-related disease endophenotypes
Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease
237 COPD cases, 204 GI cancer cases
Body mass index (change over time) in cancer or chronic obstructive pulmonary disease
1,085 cancer cases, 237 COPD cases
Body mass index (change over time) in lung cancer
112 cases
Body mass index (change over time) in gastrointestinal cancer
204 cases
Body mass index (change over time) in chronic obstructive pulmonary disease
237 cases
Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease
112 lung cancer cases, 237 COPD cases
Body mass index (change over time) in cancer
1,085 cases
Paneth cell defects in Crohn's disease
98 Japanese ancestry cases
Liver injury in anti-retroviral drug treated HIV
14 Ethiopian cases with HIV, 293 Ethiopian controls with HIV.
7 Ethiopian cases with HIV, 66 Ethiopian controls with HIV.
Liver injury in combined anti-retroviral and anti-tuberculosis drug-treated HIV with tuberculosis
27 Ethiopian cases with HIV and tuberculosis, 159 Ethiopian controls with HIV and tuberculosis.
8 Ethiopian cases with HIV and tuberculosis, up to 108 Ethiopian controls with HIV and tuberculosis.
2,283 European ancestry individuals
Progression free survival in EGFR-mutation-positive never-smoking lung adenocarcinoma treated with gefitinib or erlotinib
128 Chinese ancestry cases
153 cases, 70 Chinese ancestry cases
Pre-treatment pain in head and neck squamous cell carcinoma
148 European ancestry cases, 810 European ancestry controls
58 European ancestry cases, 352 European ancestry controls
48 Ethiopian cases with liver injury, 354 Ethiopian cases without liver injury
27 Ethiopian cases with liver injury, 217 Ethiopian cases without liver injury
Parental longevity (father's age at death)
63,775 British middle-aged individuals
2,033 individuals
Parental longevity (mother's age at death)
52,776 middle-aged British individuals
Parental longevity (combined parental age at death)
45,627 middle-aged British individuals
Parental extreme longevity (95 years and older)
1,339 middle-aged British cases, 40,934 middle-aged British controls
Aggressiveness in attention deficit hyperactivity disorder
1,060 European ancestry adult cases
750 European ancestry child cases
1,594 European ancestry individuals
350 Hispanic individuals, 138 African American individuals
Response to fenofibrate (LDL cholesterol levels)
Response to fenofibrate (total cholesterol levels)
966 European ancestry individuals
1,546 European ancestry individuals
323 European ancestry cases, 345 European ancestry controls
137 European ancestry cases, 379 European ancestry controls
3,028 European ancestry cases, 80,613 European ancestry controls
2,284 European ancestry cases, 17,184 European ancestry controls, 16,851 Black, Hispanic and European ancestry cases, 32,473 Black, Hispanic and European ancestry controls
602 European ancestry cases, 80,613 European ancestry controls
579 European ancestry cases, 3,427 Black, Hispanic and European ancestry cases, 18,515 European ancestry controls, 32,473 Black, Hispanic and European ancestry controls
Ischemic stroke (non-cardioembolic)
1,770 European ancestry cases, 80,613 European ancestry controls
335 European ancestry large-vessel ischaemic stroke cases, 365 European ancestry small-vessel ischaemic stroke cases, 2,346 Black, Hispanic and European ancestry large-vessel ischaemic stroke cases, 3,150 Black, Hispanic and European ancestry small-vessel ischaemic stroke cases, 18,515 European ancestry controls, 32,473 Black, Hispanic and European ancestry controls
4,348 European ancestry cases, 80,613 European ancestry controls
681 European ancestry cases, 1,331 European ancestry controls
7,647 European ancestry cases, 27,303 European ancestry controls
2,137 European ancestry cases, 3,168 European ancestry controls
Affymetrix, Illumina [9692718] (imputed)
112,067 European ancestry individuals
Verbal-numerical reasoning
36,035 European ancestry individuals
111,114 European ancestry individuals
111,483 European ancestry individuals
Collagenous colitis
247 European ancestry cases, 3969 European ancestry controls
67 European ancestry cases, 330 European ancestry controls
59,674 European ancestry cases, 316,078 European ancestry controls
Affymetrix, Illumina, Perlegen [8094889] (imputed)
Migraine without aura
8,348 European ancestry cases, 139,622 European ancestry controls
Migraine with aura
6,332 European ancestry cases, 144,883 European ancestry controls
Pneumococcal bacteremia
429 African ancestry cases, 2,677 African ancestry controls
113 African ancestry cases, 1,336 African ancestry controls
Bacteremia
1,536 African ancestry cases, 2,677 African ancestry controls
434 African ancestry cases, 1,336 African ancestry controls
1,743 Norwegian ancestry mothers
Gestational age at birth in labor-initiated deliveries (child effect)
884 Norwegian ancestry children
Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect)
225 Norwegian ancestry children
Gestational age at birth in labor-initiated deliveries (maternal effect)
1,407 Norwegian ancestry mothers
Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect)
336 Norwegian ancestry mothers
1,109 Norwegian ancestry children
4,384 Han Chinese ancestry cases and 5,770 Han Chinese ancestry controls
4,339 Han Chinese ancestry cases and 7,043 Han Chinese ancestry controls
Erythrocyte cadmium concentration
2,704 ever-smoker individuals, 1,728 never-smoker individuals
Erythrocyte cadmium concentration in never smokers
1,728 individuals
352 European ancestry cases, 537 European ancestry controls
828 European ancestry cases, 1,378 European ancestry controls
Rheumatoid factor seropositivity in rheumatoid arthritis
896 Spanish ancestry rheumatoid factor-positive cases, 282 Spanish ancestry rheumatoid factor-negative cases
472 Spanish ancestry rheumatoid factor-positive cases, 190 Spanish ancestry rheumatoid factor-negative cases
32,330 European ancestry individuals
2,660 African American individuals, 2,967 European ancestry individuals
Affymetrix, Illumina [6444471] (imputed)
166 European ancestry responder cases, 171 European ancestry non-responder cases
S-phenylmercapturic acid levels in smokers
364 African American current smoker individuals, 311 Native Hawaiian ancestry current smoker individuals, 437 European ancestry current smoker individuals, 453 Latino ancestry current smoker individuals, 674 Japanese American ancestry current smoker individuals
Cognitive impairment (brain beta-amyloid deposition interaction)
251 European ancestry early mild cases, 122 European ancestry late mild cases, 108 European ancestry Alzheimer's disease cases, 197 European ancestry controls
280 European ancestry mild cases, 287 European ancestry Alzheimer's disease cases, 382 European ancestry controls
907 European ancestry cases, 3,866 European ancestry controls
Estrogen receptor status in HER2 positive breast cancer
1,944 French ancestry estrogen receptor positive cases, 1,331 French ancestry estrogen receptor negative cases
Estrogen receptor status in HER2 negative breast cancer
4,267 French ancestry estrogen receptor positive cases, 1,185 French ancestry estrogen receptor negative cases
Estrogen receptor status in breast cancer
6,211 French ancestry estrogen receptor positive cases, 2,516 French ancestry estrogen receptor negative cases
Gastroesophageal reflux disease
2,247 European ancestry cases, 4,503 European ancestry controls
Severity of facial solar lentigines
502 French ancestry individuals
6,912 European ancestry individuals
845 African American individuals, 446 Hispanic individuals, 971 European ancestry individuals
127,898 British individuals
89,283 individuals
127,573 British individuals
47,180 individuals
Morning vs. evening chronotype
114,765 British individuals
Sleep duration (oversleepers vs undersleepers)
10,102 British oversleeper individuals, 28,980 British undersleeper indivdiuals
Sleep duration (oversleepers)
10,102 British ancestry cases, 81,204 British ancestry controls
Sleep duration (undersleepers)
28,980 British ancestry cases, 81,208 British ancestry controls
EGFR mutation-positive lung adenocarcinoma
663 Japanese ancestry cases, 4,367 Japanese ancestry controls
2,510 Japanese ancestry cases, 10,791 Japanese ancestry controls
242 Han Chinese ancestry cases, 1,444 Han Chinese ancestry controls
178 Han Chinese ancestry cases, 14,432 Han Chinese ancestry controls
7,399 European ancestry women, 7,381 European ancestry men, 2,163 African American women, 1,304 African American men
7,431 European ancestry women, 7,432 European ancestry men, 2,163 African American women, 1,306 African American men
Pericardial adipose tissue adjusted for height and weight
3,684 European ancestry women, 3,640 European ancestry men, 1,284 African American women, 877 African American men, 746 Hispanic Ancestry women, 699 Hispanic ancestry men, 390 Asian ancestry women, 378 Asian ancestry men, 294 Old Order Amish (founder/genetic isolate) women, 248 Old Order Amish (founder/genetic isolate) men.
Visceral adipose tissue adjusted for BMI
Pericardial fat
Subcutaneous adipose tissue attenuation (Hounsfield unit scale)
5,699 European ancestry women, 5,699 European ancestry men, 592 African American women, 449 African American men.
Visceral adipose tissue attenuation (Hounslow unit scale)
5,729 European ancestry women, 5,749 European ancestry men, 592 African American women, 449 African American men.
7,618 European ancestry women, 7,050 European ancestry men, 2,205 African American women, 1,324 African American men.
Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI
7,432 European ancestry men, 1,306 African American men
7,431 European ancestry women, 2,163 African American women
7,399 European ancestry women, 2,163 African American women
7,381 European ancestry men, 1,304 African American men
3,640 European ancestry men, 877 African American men, 699 Hispanic ancestry men, 378 Asian ancestry men, 248 Old Order Amish (founder/genetic isolate) men.
3,684 European ancestry women, 1,284 African American women, 746 Hispanic Ancestry women, 390 Asian ancestry women, 294 Old Order Amish (founder/genetic isolate) women
5,699 European ancestry women, 592 African American women
5,699 European ancestry men, 449 African American men
5,749 European ancestry men, 449 African American men
5,729 European ancestry women, 592 African American women
7,050 European ancestry men, 1,324 African American men
7,618 European ancestry women, 2,205 African American women
76,551 European ancestry individuals
Affymetrix, Illumina [2165398] (imputed)
46,581 European ancestry individuals
Affymetrix, Illumina [2166809] (imputed)
122,886 European ancestry individuals
46,621 European ancestry individuals
Affymetrix, Illumina [6343667] (imputed)
122,867 European ancestry individuals
137,994 European ancestry individuals
Affymetrix, Illumina [6337541] (imputed)
76,581 European ancestry individuals
Affymetrix, Illumina [2167320] (imputed)
Pathological gambling
445 European ancestry cases, 986 European ancestry controls
Endometrial endometrioid carcinoma
2,082 European ancestry cases, 9,544 European ancestry controls
4,553 European ancestry cases, 27,600 European ancestry controls
2,082 European ancestry endometrioid cases, 130 European ancestry cases, 9,544 European ancestry controls
4,553 European ancestry endometrioid cases, 972 European ancestry cases, 27,600 European ancestry controls
Asthma (SNP x SNP interaction)
802 European ancestry cases, 823 European ancestry controls
754 European ancestry cases, 57 European and unknown ancestry cases, 2,573 cases, 880 European ancestry controls, 68 European and unknown ancestry controls, 2,145 controls
1,659 Chinese ancestry cases, 3,398 Chinese ancestry controls, 4,036 European ancestry cases, 6,959 European ancestry controls
3,043 Chinese ancestry cases, 5,074 Chinese ancestry controls, 2,643 European ancestry cases, 9,032 European ancestry controls
Response to carboplatin in ovarian cancer (MTT IC50)
74 lymphoblastoid cell lines
Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50)
Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50)
Response to carboplatin in ovarian cancer (Caspase 3/7 EC50)
Response to paclitaxel in ovarian cancer (MTT IC50)
Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50)
155 French ancestry cases, 314 French ancestry controls
40 European ancestry cases, 74 European ancestry controls
Clinical laboratory measurements
17,347 European ancestry individuals
17,348 European ancestry individuals
C-reactive protein levels or triglyceride levels (pleiotropy)
65,000 individuals (C-reactive protein), 96,598 individuals (triglycerides)
C-reactive protein levels or HDL-cholesterol levels (pleiotropy)
65,000 individuals (C-reactive protein), 99,900 individuals (HDL-cholesterol)
C-reactive protein levels or LDL-cholesterol levels (pleiotropy)
65,000 individuals (C-reactive protein), 95,454 individuals (LDL-cholesterol)
C-reactive protein levels or total cholesterol levels (pleiotropy)
65,000 individuals (C-reactive protein), 100,184 individuals (total cholesterol)
Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder
5,167 European ancestry bipolar disorder cases, 2,950 European ancestry ADHD cases, 1,659 European and unknown ancestry ADHD cases, 16,325 European ancestry controls, 2,942 European and unknown ancestry controls, 2,096 controls
Bipolar disorder or attention deficit hyperactivity disorder
9,650 European ancestry bipolar disorder cases, 2,950 European ancestry ADHD cases, 1,659 European and unknown ancestry ADHD cases, 16,325 European ancestry controls, 2,942 European and unknown ancestry controls, 2,096 controls
Number of children ever born
225,230 European ancestry women, 103,909 European ancestry men
Age at first birth
189,656 European ancestry women, 48,408 European ancestry men
103,909 European ancestry men
225,230 European ancestry women
48,408 European ancestry men
189,656 European ancestry women
Skin fluorescence in type 1 diabetes
1,359 European ancestry cases
Antithyroid drug-induced agranulocytosis
20 Southern Chinese ancestry cases, 775 East Asian ancestry controls
4 Southern Chinese ancestry cases, 387 East Asian ancestry controls
Resistance to antihypertensive treatment in hypertension
1,719 European ancestry resistant cases, 708 European ancestry controlled hypertensives, 1,111 African American, Hispanic and other ancestry resistant cases, 168 African American, Hispanic and other ancestry controlled hypertensives
Affymetrix, Illumina [2530150] (imputed)
8,839 Korean ancestry individuals.
19,546 British ancestry individuals from 6863 families.
19,547 British ancestry individuals from 6863 families.
15,226 British ancestry non-diabetics individuals from 6863 families, 948 British ancestry diabetic individuals from 6863 families.
19,223 British ancestry individuals from 6863 families.
19,900 British ancestry individuals from 6863 families.
19,259 British ancestry individuals from 6863 families.
19,480 British ancestry individuals from 6863 families.
2077 British ancestry individuals from 6863 families.
19,965 British ancestry individuals from 6863 families.
19,920 British ancestry individuals from 6863 families.
16,347 British ancestry from 6863 families.
19,293 British ancestry individuals from 6863 families.
19,695 British ancestry individuals from 6863 families.
10,210 European ancestry cases, 12,285 European ancestry controls
7,743 European ancestry cases, 17,970 European ancestry controls
1,715 European ancestry cases, 12,285 European ancestry controls
3,101 European ancestry cases, 38,443 European ancestry controls
2,275 European ancestry cases, 12,285 European ancestry controls
1,928 European ancestry cases, 38,443 European ancestry controls
1,877 European ancestry cases, 12,285 European ancestry controls
1,130 European ancestry cases, 17,970 European ancestry controls
Prostate-specific antigen levels
28,503 European ancestry individuals
2,716 Latino individuals, 2,518 East Asian ancestry individuals, 1,585 African American individuals, 6,193 European ancestry individuals (later diagnosed with prostate cancer), 5,603 European ancestry individuals
Prostate-specific antigen levels (conditioned on lead SNPs)
2,716 Latino individuals, 2,518 East Asian ancestry individuals, 1,585 African American individuals, 6,193 European ancestry individuals (later diagnosed with prostate cancer)
Drug-induced liver injury (terbinafine)
14 European ancestry cases, 10,588 European ancestry controls.
Drug-induced hepatocellular liver injury
474 European ancestry cases, 10,588 European ancestry controls
Drug-induced liver injury (statins)
59 European ancestry cases, 10,588 European ancestry controls
Drug-induced cholestatic/mixed liver injury
323 European ancestry cases, 10,588 European ancestry controls.
Drug-induced liver injury (nitrofurantoin)
64 European ancestry cases, 10,588 European ancestry controls
Drug-induced liver injury (diclofenac)
67 European ancestry cases, 10,588 European ancestry controls
Drug-induced liver injury (anti-tuberculosis drugs)
Drug-induced liver injury (fluoroquinolones)
43 European ancestry cases, 10,588 European ancestry controls
Drug-induced liver injury (nonsteroidal anti-inflammatory drugs)
144 European ancestry cases, 10,588 European ancestry controls
862 European ancestry cases and 10,588 European ancestry controls
20,353 European ancestry individuals, 2,131 Erasmus Rucphen (founder/genetic isolate) individuals
7,333 Asian ancestry individuals
21,768 European ancestry individuals, 2,131 Erasmus Rucphen (founder/genetic isolate) individuals
8,168 Asian ancestry individuals
20,373 European ancestry individuals, 2,131 Erasmus Rucphen (founder/genetic isolate) individuals
7,302 Asian ancestry individuals
25,916 European ancestry individuals, 1,073 Orcadian (founder/genetic isolate) individuals, 2,589 Erasmus Rucphen (founder/genetic isolate) individuals
8,352 Asian ancestry individuals
Caffeine metabolism (plasma 1,3,7-trimethyluric acid level)
3,562 European ancestry individuals
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level)
5,353 European ancestry individuals
833 European ancestry individuals
Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level)
8,911 European ancestry individuals
824 European ancestry individuals
Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level)
9,054 European ancestry individuals
Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level)
5,261 European ancestry individuals
826 European ancestry individuals
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)
5,323 European ancestry individuals
1,174 Korean ancestry cases, 4,246 Korean ancestry controls
739 Korean ancestry cases, 677 Chinese ancestry cases, 436 Korean ancestry controls, 709 Chinese ancestry controls
4,842 European ancestry cases, 286,565 European ancestry controls
1,804 European ancestry cases, 1,026 European ancestry controls
Gallbladder cancer
1,042 Indian ancestry cases, 1,709 Indian ancestry controls
428 Indian ancestry cases, 420 Indian ancestry controls
Venous thromboembolism adjusted for sickle cell variant rs77121243-T
393 African American cases, 4,941 African American controls.
Affymetrix, Illumina [14074516] (imputed)
140,886 European ancestry individuals
190,318 European ancestry individuals
140,882 European ancestry individuals
Sepsis in extremely premature infants
155 European ancestry cases, 190 non-European ancestry cases, 184 European ancestry controls, 222 non-European ancestry controls
1,894 African American ancestry cases, 4,703 African American ancestry controls.
891 African American ancestry cases, 1,150 African American ancestry controls, 1,611 Hispanic ancestry cases, 4,330 Hispanic ancestry controls.
443 African American ancestry cases, 4,703 African American ancestry controls.
284 African American ancestry cases, 1,150 African American ancestry controls
1,451 African American ancestry cases, 4,703 African American ancestry controls.
607 African American ancestry cases, 1,146 African American ancestry controls.
Lung function (FEV1/FVC) in asthma (dust mite allergen exposure interaction)
440 Puerto Rican ancestry child cases
497 European ancestry child cases, 605 Hispanic child cases
Lung function (FEV1) in asthma (dust mite allergen exposure interaction)
Daytime sleep phenotypes
Night sleep phenotypes
941 European ancestry individuals
Carotenoid levels (cryptoxanthin)
433 Old Order Amish individuals
Carotenoid levels (alpha-carotene)
Vitamin E levels (alpha-tocopherol)
Carotenoid levels (beta-carotene)
Carotenoid levels (lutein)
Carotenoid levels (zeaxanthin)
Vitamin E levels (gamma-tocopherol)
Retinol levels
Otitis media
803 Finnish ancestry child cases, 2,073 Finnish ancestry controls
Otitis media (chronic)
512 Finnish ancestry child cases, 2,073 Finnish ancestry controls
1,466 child cases, 3,394 controls
Otitis media (recurrent)
702 Finnish ancestry child cases, 2,073 Finnish ancestry controls
L-arginine levels
901 European ancestry individuals, 1,394 Indian Asian ancestry individuals
1,000 European ancestry individuals, 2,981 individuals
97 African admixed Arab ancestry cases, 410 non-African admixed Arab ancestry cases, 4 Arab ancestry cases, 56 African admixed Arab ancestry controls, 290 non-African admixed Arab ancestry controls, 6 Arab ancestry controls
283 Arab ancestry cases, 221 Arab ancestry controls
Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive)
357 African admixed and non-African admixed Arab ancestry cases, 352 African admixed and non-African admixed Arab ancestry controls
234 Arab ancestry cases, 225 Arab ancestry controls
Rheumatoid arthritis (rheumatoid factor and anti-cyclic citrullinated peptide seronegative)
154 African admixed and non-African admixed Arab ancestry cases, 352 African admixed and non-African admixed Arab ancestry controls
54 Arab ancestry cases, 225 Arab ancestry controls
Response to platinum-based neoadjuvant chemotherapy in cervical cancer
66 Han Chinese ancestry non-responder cases, 160 Han Chinese ancestry responder cases
79 Han Chinese ancestry non-responder cases, 291 Han Chinese ancestry responder cases
10,778 European ancestry individuals, 2,706 African American individuals
Affymetrix [at least 22484459] (imputed)
Bronchiolitis
217 European ancestry child cases, 778 European ancestry controls
618 European ancestry child cases, 1,318 European ancestry controls
11,157 European ancestry cases, 36,699 European ancestry controls, 1,142 African American cases, 2,380 African American controls, 199 Korean ancestry cases, 6,741 Korean ancestry controls, 52 Hispanic cases, 548 Hispanic controls.
12,051 European ancestry cases, 11,111 European ancestry controls, 153 Korean ancestry cases, 205 Korean ancestry controls.
Acute-on-chronic liver failure in hepatitis B
389 Chinese ancestry cases, 391 Chinese ancestry controls
901 Chinese ancestry cases, 1,686 Chinese ancestry controls
48,943 European ancestry individuals.
57,176 European ancestry individuals, 38,199 individuals.
48,943 European ancestry individuals
26,814 European ancestry individuals
up to 3,863 European ancestry individuals, up to 562 African American individuals, up to 886 Asian ancestry individuals, up to 1,411 Mexican American individuals
399 European ancestry cases, 1,318 European ancestry controls, 666 European ancestry trios, 795 Asian trios
224 European ancestry cases, 921 European ancestry controls, 152 Mayan cases, 323 Mayan controls, 198 Middle Eastern cases, 391 Middle Eastern controls
550 European, Asian and unknown trios
2,637 European ancestry cases, 364 non-array typed, familial imputed Icelandic ancestry cases, 134,811 European ancestry controls, 152,739 non-array typed, familial imputed Icelandic ancestry controls.
Self-reported tiredness
108,976 British ancestry individuals
4,478 European ancestry cases and 13,213 European ancestry controls.
1,722 European ancestry cases and 4,385 European ancestry controls.
Plasma t-tau levels
463 European ancestry Alzheimer's disease cases, 163 European ancestry individuals with mild cognitive impairment, 151 European ancestry individuals
360 individuals, 27 individuals later diagnosed with mild cognitive impairment
Takotsubo syndrome
96 European ancestry cases, 475 controls
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease)
18,467 European and unknown ancestry cases, 45,264 European and unknown ancestry controls
57,347 European and unknown ancestry cases, 219,521 European and unknown ancestry controls
Femoral neck bone mineral density or plasma lipids (pleiotropy)
49,988 European and unknown ancestry individuals with femoral neck bone mineral density measurements, 188,577 European and unknown ancestry individuals with plasma lipid measurements
Insulin sensitivity index
up to 4,565 European individuals, up to 413 Old Order Amish (founder/genetic isolate) individuals
20,514 non-diabetic individuals
Affymetrix, Illumina [at least 1961018] (imputed)
Insulin levels
up to 4,483 European individuals, up to 441 Old Order Amish (founder/genetic isolate) individuals
20,792 European individuals
Insulin levels adjusted for BMI
up to 4,409 European individuals, up to 411 Old Order Amish (founder/genetic isolate) individuals
18,535 European individuals
up to 4,746 European individuals, up to 412 Old Order Amish (founder/genetic isolate) individuals
20,461 European individuals
Ratio of the area under the curve for insulin and the area under the curve for glucose
up to 4,231 European individuals, up to 413 Old Order Amish (founder/genetic isolate) individuals
20,513 European individuals
Area under the curve of insulin levels
up to 4,324 European individuals, up to 413 Old Order Amish (founder/genetic isolate) individuals
20,620 European individuals
Incremental insulin
up to 4,447 European individuals, up to 411 Old Order Amish (founder/genetic isolate) individuals
20,706 European individuals
Corrected insulin response
up to 4,961 European individuals, up to 411 Old Order Amish (founder/genetic isolate) individuals
20,722 European individuals
Corrected insulin response adjusted for insulin sensitivity index
Plasma kynurenine levels in major depressive disorder
Plasma kynurenine to tryptophan ratio in major depressive disorder
560 Ugandan ancestry cases, 480 Ugandan ancestry controls
6,312 Japanese ancestry individuals
4,949 Japanese ancestry individuals
11,261 Japanese ancestry individuals
Thrombin-activatable fibrinolysis inhibitor levels
3,116 European ancestry individuals
Thrombin-activatable fibrinolysis inhibitor activation peptide
3,124 European ancestry individuals
Disease progression in age-related macular degeneration
1,105 progressed eyes and 3,912 non-progressed eyes from 2,721 European ancestry individuals
Disease progression to geographic atrophy form in age-related macular degeneration
615 progressed eyes and 3,912 non-progressed eyes from up to 2,721 European ancestry individuals
Disease progression to choroidal neovascularization form in age-related macular degeneration
508 progressed eyes and 3,912 non-progressed eyes from up to 2,721 European ancestry individuals
Disease progression in age-related macular degeneration (adjusted for baseline)
Circulating chemerin levels
1,967 European ancestry individuals, 824 Sorbian (founder/genetic isolate) individuals
967 individuals
Atazanavir levels
64 European ancestry women, 194 African American women, 130 Hispanic women, 10 women
79 women
up to 72,390 Japanese ancestry women, up to 85,894 Japanese ancestry men
up to 10,048 Japanese ancestry women, up to 5,098 Japanese ancestry men, up to 181,999 European ancestry women, up to 140,155 European ancestry controls
88,355 European ancestry individuals,18,472 East Asian ancestry individuals, 7,572 South Asian ancestry individuals, 7,564 African American individuals
33,238 European ancestry individuals, 2,366 East Asian ancestry individuals, 1,302 South Asian ancestry individuals
7,572 South Asian ancestry individuals
88,355 European ancestry individuals
7,564 African American individuals
18,472 East Asian ancestry individuals
6,997 European ancestry female cases, 16,172 European ancestry female controls, 3,852 European ancestry male cases, 16,034 European ancestry male controls
Affymetrix, Illumina [7105178] (imputed)
Recurrent major depressive disorder
7,345 European ancestry female cases, 32,211 European ancestry female controls
576 Japanese ancestry cases, 6,270 East Asian controls
236 Japanese ancestry cases, 6,270 East Asian ancestry controls
Dermatomyositis
340 Japanese ancestry cases, 6,270 East Asian ancestry controls
Clinically amyopathic dermatomyositis
33 Japanese ancestry cases, 6,270 East Asian ancestry controls
21 European ancestry cases, 84 European ancestry controls
Schizophrenia or general cognitive function (pleiotropy)
34,486 schizophrenia cases, 45,271 controls, 81,837 individuals with cognitive function data
Schizophrenia or reaction time (pleiotropy)
34,486 schizophrenia cases, 45,271 controls, 111,483 individuals with reaction time data
Schizophrenia or verbal-numerical reasoning (pleiotropy)
34,486 schizophrenia cases, 45,271 controls, 36,035 individuals with verbal-numerical reasoning data
Osteoarthritis or lumbar spine bone mineral density
6,694 osteoarthritis cases, 10,968 osteoarthritis controls, 31,800 individuals
Hip osteoarthritis or lumbar spine bone mineral density
3,032 hip osteoarthritis cases, 10,968 osteoarthritis controls, 31,800 individuals
Knee osteoarthritis or lumbar spine bone mineral density
3,088 knee osteoarthritis cases, 10,968 osteoarthritis controls, 31,800 individuals
Osteoarthritis or femoral neck bone mineral density
6,694 osteoarthritis cases, 10,968 osteoarthritis controls, 32,961 individuals
Hip osteoarthritis or femoral neck bone mineral density
3,032 hip osteoarthritis cases, 10,968 osteoarthritis controls, 32,961 individuals
Knee osteoarthritis or femoral neck bone mineral density
3,088 knee osteoarthritis cases, 10,968 osteoarthritis controls, 32,961 individuals
Schizophrenia or lung cancer (pleiotropy)
32,405 European and unknown ancestry schizophrenia cases, 12,160 European and unknown ancestry lung cancer cases, 59,059 European and unknown ancestry controls
Schizophrenia or cigarettes per day (pleiotropy)
32,405 European and unknown ancestry schizophrenia cases, 74,503 smoker individuals, 42,221 European and unknown ancestry controls
Vitamin D levels (dietary vitamin D intake interaction)
39,868 European ancestry individuals
2,113 European ancestry individuals
Affymetrix, Illumina [at least 1200000] (imputed)
79,366 European ancestry individuals
42,757 European and unknown ancestry individuals
Affymetrix, Illumina [up to 3600000] (imputed)
8,541 African American individuals, 3,485 Hispanic American individuals, 16,124 European ancestry individuals
Affymetrix, Illumina [at least 398246] (imputed)
120,473 European ancestry individuals, 21,503 African American individuals, 4,586 Hispanic individuals
154,543 European ancestry individuals, 26,183 South Asian ancestry individuals
645 European ancestry cases
607 European ancestry cases
647 European ancestry cases
606 European ancestry cases
Sex hormone-binding globulin levels in polycystic ovary syndrome
903 European ancestry cases
1,156 European ancestry cases
Testosterone levels in polycystic ovary syndrome
957 European ancestry cases
1,516 European ancestry cases
984 European ancestry cases, 2,964 European ancestry controls
2,021 European ancestry cases, 2,566 European ancestry controls
DHEAS levels in polycystic ovary syndrome
up to 984 European ancestry cases
up to 2,021 European ancestry cases
Helping behaviour (self reported)
10,713 European ancestry, African American and unknown ancestry individuals
1,949 Latino cases, 8,584 Latino controls, 1,184 European ancestry cases, 3551 European ancestry controls, 130 African American cases, 3,842 African American controls
959 European ancestry cases, 2,624 European ancestry controls, 530 Latino cases, 511 Latino controls
Eosinophil percentage of white cells
172,378 European ancestry individuals
172,433 European ancestry individuals
166,066 European ancestry individuals
173,039 European ancestry individuals
172,851 European ancestry individuals
172,275 European ancestry individuals
Plateletcrit
164,339 European ancestry individuals
Granulocyte percentage of myeloid white cells
169,545 European ancestry individuals
Monocyte percentage of white cells
170,494 European ancestry individuals
172,435 European ancestry individuals
High light scatter reticulocyte count
170,761 European ancestry individuals
Sum neutrophil eosinophil counts
170,384 European ancestry individuals
Granulocyte count
169,822 European ancestry individuals
High light scatter reticulocyte percentage of red cells
170,763 European ancestry individuals
172,925 European ancestry individuals
Platelet distribution width
164,433 European ancestry individuals
Eosinophil percentage of granulocytes
170,536 European ancestry individuals
White blood cell count (basophil)
171,846 European ancestry individuals
Reticulocyte fraction of red cells
170,690 European ancestry individuals
Sum basophil neutrophil counts
170,143 European ancestry individuals
171,529 European ancestry individuals
Reticulocyte count
170,641 European ancestry individuals
Neutrophil percentage of granulocytes
170,672 European ancestry individuals
Sum eosinophil basophil counts
171,771 European ancestry individuals
170,721 European ancestry individuals
Rubella-specific interferon-gamma secretion
1,643 European ancestry individuals, 202 African American individuals
Rubella-specific interleukin-6 secretion
Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes
345 African American cases, 346 African American controls
137 African American cases, 68 African American controls
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes
691 African American individuals
205 African American individuals
Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes
Response to radiotherapy in prostate cancer (toxicity, urinary frequency)
1,409 European ancestry individuals
1,245 European ancestry individuals
1,346 European ancestry individuals
Response to radiotherapy in prostate cancer (toxicity, rectal bleeding)
1,487 European ancestry individuals
Low vWF levels
up to 1,635 European ancestry individuals with low vWF levels, up to 33,286 European ancestry individuals with normal vWF levels
785 Japanese ancestry cases, 3,383 Japanese ancestry controls
2,379 Japanese ancestry cases, 16,752 Japanese ancestry controls
165 East Asian ancestry male cases, 84 East Asian ancestry female cases, 783 East Asian ancestry male controls, 217 East Asian ancestry female controls
705 East Asian ancestry male cases, 507 East Asian ancestry female cases, 1,484 East Asian ancestry male controls, 2,818 East Asian ancestry female controls, 64 male cases, 36 female cases, 180 male controls, 67 male controls
Immunoglobulin light chain (AL) amyloidosis (serum Ig light chain only lambda based profile)
404 cases, controls
Immunoglobulin light chain (AL) amyloidosis (liver involvement)
194 cases, controls
Immunoglobulin light chain (AL) amyloidosis (heart and kidney involvement)
426 cases, controls
Immunoglobulin light (AL) amyloidosis (serum Ig kappa profile)
85 cases, controls
Immunoglobulin light chain (AL) amyloidosis (serum Ig light chain only lambda/kappa based profile)
535 cases, controls
Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile)
345 cases, controls
Immunoglobulin light chain (AL) amyloidosis (heart involvement)
835 cases, controls
Immunoglobulin light chain (AL) amyloidosis (kidney involvement)
844 cases, controls
Immunoglobulin light chain (AL) amyloidosis (serum IgG profile)
447 cases, controls
38 European ancestry cases, 835 European ancestry controls, 21 Hispanic cases, 626 Hispanic controls, 2 Asian ancestry cases, 161 Asian ancestry controls, 38 Indian ancestry controls, 15 Sub-Saharan African ancestry cases, 2 African American cases, 68 Sub-Saharan African ancestry controls, 5 African American controls, 1 African control, 4 controls
246 European ancestry cases, 1,685 European ancestry controls
114 European ancestry case-parent trios, 30 Hispanic case-parent trios, 39 East Asian case-parent trios, 1 South East Asian ancestry case-parent trio, 5 Sub-Saharan African case-parent trios
38 European ancestry cases, 835 European ancestry controls, 21 Hispanic cases, 626 Hispanic controls, 2 Asian ancestry cases, 161 Asian ancestry controls, 38 Indian ancestry controls, 15 Sub-Saharan African ancestry cases, 2 African American cases, 68 Sub-Saharan African ancestry controls, 5 African American controls, 1 African control, 4 controls, 114 European ancestry case-parent trios, 30 Hispanic case-parent trios, 39 East Asian case-parent trios, 1 South East Asian ancestry case-parent trio, 5 Sub-Saharan African case-parent trios
B cell acute lymphoblastic leukaemia (normal cytogenetics)
193 European ancestry cases, 3027 European ancestry controls
B cell acute lymphoblastic leukaemia (hyperdiploid negative)
410 European ancestry cases, 3027 European ancestry controls
B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative)
333 European ancestry cases, 3,027 European ancestry controls
B cell acute lymphoblastic leukaemia (abnormal cytogenetics)
253 European ancestry cases, 3,027 European ancestry controls
134 European ancestry cases, 3,027 European ancestry controls
B cell acute lymphoblastic leukaemia in young adulthood
160 European ancestry cases, 3,027 European ancestry controls
B cell acute lymphoblastic leukaemia in adulthood
152 European ancestry cases, 3,027 European ancestry controls
272 European ancestry male cases, 174 European ancestry female cases, 2,098 European ancestry male controls, 929 European ancestry female controls
Taxane-induced peripheral neuropathy in breast cancer
204 European ancestry cases with ≥ grade 3 neuropathy, 1,919 European ancestry cases with < grade 3 neuropathy, 31 African American cases with ≥ grade 3 neuropathy, 108 African American cases with <grade 3 neuropathy
Duloxetine response in major depressive disorder (remitter/non-remitter status)
186 European ancestry individuals
Duloxetine response in major depressive disorder (responder/non-responder status)
Placebo response in major depressive disorder (remitter/non-remitter status)
205 European ancestry individuals
Placebo response in major depressive disorder (responder/non-responder status)
Duloxetine response in major depressive disorder (% change in symptom score)
Placebo response in major depressive disorder (% change in symptom score)
Lobe attachment (rater-scored or self-reported)
66,741 European ancestry individuals, 5,062 Hispanic individuals, 2,857 Han Chinese ancestry individuals
Lobe attachment (rater scored)
1791 European ancestry individuals, 5,062 Hispanic individuals, 2,857 Han Chinese ancestry individuals
377 East Asian ancestry individuals
568 East Asian ancestry individuals
1,310 European ancestry cases, 7,859 European ancestry controls
1,963 European ancestry cases, 4,329 European ancestry controls
2,287 European ancestry whole-genome sequenced individuals, 14,048 European ancestry individuals
2,287 European ancestry whole-genome sequenced individuals, 11,364 European ancestry individuals
B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio
4,932 Finnish ancestry individuals
1,373 Finnish ancestry individuals
Midregional pro atrial natriuretic peptide levels
N-terminal pro B-type natriuretic peptide levels
B-type natriuretic peptide levels
3,072 Samoan (founder/genetic isolate) individuals
2,102 Samoan (founder/genetic isolate) individuals
704 African American individuals
425 West African individuals
697 African American individuals
706 African American individuals
986 European ancestry cases, 4,946 European ancestry controls
4,009 cases, 4,066 controls
1,064 European ancestry cases, 4,009 cases, 10,082 European ancestry controls, 4,066 controls
Response to exercise (triglyceride level interaction)
478 European ancestry individuals from 99 families
1,254 whole genome sequenced European ancestry individuals, 3,072 whole genome sequenced individuals, 41,450 European ancestry individuals, 397 Carlantino (founder/genetic isolate) individuals, 791 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,060 Mylopotamos (founder/genetic isolate) individuals, 887 Pomak (founder/genetic isolate) individuals, 1,754 Val Borbera (founder/genetic isolate) individuals
206,737 European ancestry individuals
Affymetrix, Illumina, Perlegen [15844966] (imputed)
1,249 whole genome sequenced European ancestry individuals, 3,559 whole genome sequenced individuals, 46,819 European ancestry individuals, 472 Carlantino (founder/genetic isolate) individuals, 1,172 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,051 Mylopotamos (founder/genetic isolate) individuals, 942 Pomak (founder/genetic isolate) individuals, 1,779 Val Borbera (founder/genetic isolate) individuals
179,022 European ancestry individuals
3,399 whole genome sequenced individuals, 11,801 European ancestry individuals
10,676 European ancestry individuals
Trunk fat mass
3,399 whole genome sequenced individuals, 12,838 European ancestry individuals
10,667 European ancestry individuals
1,254 whole genome sequenced European ancestry individuals, 3,071 whole genome sequenced individuals, 29,723 European ancestry individuals, 388 Carlantino (founder/genetic isolate) individuals, 791 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,053 Mylopotamos (founder/genetic isolate) individuals, 879 Pomak (founder/genetic isolate) individuals
206,053 European ancestry individuals
Hip circumference adjusted for BMI
1,247 whole genome sequenced European ancestry individuals, 3,052 whole genome sequenced individuals, 29,518 European ancestry individuals, 400 Carlantino (founder/genetic isolate) individuals, 831 Friuli Venezia Giulia (founder/genetic isolate) individuals, 998 Mylopotamos (founder/genetic isolate) individuals, 871 Pomak (founder/genetic isolate) individuals
205,905 European ancestry individuals
1,249 whole genome sequenced European ancestry individuals, 3,541 whole genome sequenced individuals, 46,910 European ancestry individuals, 471 Carlantino (founder/genetic isolate) individuals, 1,197 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,043 Mylopotamos (founder/genetic isolate) individuals, 933 Pomak (founder/genetic isolate) individuals, 1,785 Val Borbera (founder/genetic isolate) individuals
205,003 European ancestry individuals
3,399 whole genome sequenced individuals, 11,802 European ancestry individuals
10,670 European ancestry individuals
1,249 whole genome sequenced European ancestry individuals, 3,538 whole genome sequenced individuals, 46,635 European ancestry individuals, 472 Carlantino (founder/genetic isolate) individuals, 1,170 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,019 Mylopotamos (founder/genetic isolate) individuals, 932 Pomak (founder/genetic isolate) individuals, 1,778 Val Borbera (founder/genetic isolate) individuals
209,191 European ancestry individuals
1,247 whole genome sequenced European ancestry individuals, 3,049 whole genome sequenced individuals, 29,518 European ancestry individuals, 388 Carlantino (founder/genetic isolate) individuals, 790 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,001 Mylopotamos (founder/genetic isolate) individuals, 867 Pomak (founder/genetic isolate) individuals
206,045 European ancestry individuals
1,247 whole genome sequenced European ancestry individuals, 3,050 whole genome sequenced individuals, 41,027 European ancestry individuals, 397 Carlantino (founder/genetic isolate) individuals, 790 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,005 Mylopotamos (founder/genetic isolate) individuals, 875 Pomak (founder/genetic isolate) individuals, 1,754 Val Borbera (founder/genetic isolate) individuals
206,723 European ancestry individuals
1,254 whole genome sequenced European ancestry individuals, 3,074 whole genome sequenced individuals, 29,716 European ancestry individuals, 400 Carlantino (founder/genetic isolate) individuals, 701 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,050 Mylopotamos (founder/genetic isolate) individuals, 883 Pomak (founder/genetic isolate) individuals
205,909 European ancestry individuals
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)
5,766 European ancestry cases, 811 African American cases
Intelligence (MTAG)
120,934 British ancestry individuals, 127,548 individuals
26,577 European ancestry individuals
2,362 European ancestry individuals, 938 African American individuals, 955 Asian ancestry individuals, 1,605 Hispanic individuals
Dysmenorrheic pain
1,785 European ancestry individuals with no pain, 3,478 European ancestry individuals with little pain, 4,208 European ancestry individuals with moderate pain, 2,420 European ancestry individuals with extreme pain
1,023 Han Chinese ancestry cases and 1,306 Han Chinese ancestry controls
5,317 Han Chinese ancestry cases, 6,887 Han Chinese ancestry controls, 1,046 European ancestry cases, 1,076 European ancestry controls
2,605 European ancestry individuals, 1,233 African American individuals
Coenzyme Q10 levels
up to 1,300 European ancestry individuals
Affymetrix, Illumina [up to 17017474] (imputed)
1983 European ancestry individuals, 747 Erasmus Rucphen (founder/genetic isolate) individuals, 610 Korculan (founder/genetic isolate) individuals, 696 Tyrolean (founder/genetic isolate) individuals, 206 Orcadian (founder/genetic isolate) individuals
30,377 European ancestry individuals
Affymetrix, Illumina, Perlegen [2572737] (imputed)
Job-related exhaustion in shift workers
176 Finnish ancestry individuals
577 Finnish ancestry individuals
Bipolar disorder (early onset)
600 European ancestry cases, 1,811 European ancestry controls
142 European ancestry cases, 746 European ancestry controls
Affymetrix, Illumina [7859701] (imputed)
Drug abuse
2,017 African American ancestry cases, 1,142 European ancestry cases,1,725 African American ancestry controls, 5,703 European ancestry controls
259 African American ancestry cases, 273 European ancestry cases, 496 African American ancestry controls, 858 European ancestry controls
Sciatica
291 Finnish (founder/genetic isolate) cases, 3,671 Finnish (founder/genetic isolate) controls
776 Finnish (founder/genetic isolate) cases, 18,489 Finnish (founder/genetic isolate) controls
127 Han Chinese ancestry case, 1,566 Han Chinese ancestry controls
Depression in response to interferon-based therapy in chronic hepatitis C
45 Japanese ancestry cases, 179 Japanese ancestry controls
40 Japanese ancestry cases, 120 Japanese ancestry controls
5,612 East Asian ancestry cases, 12,451 East Asian ancestry controls, 337 Indian ancestry cases, 2,538 Indian ancestry controls, 576 European ancestry cases, 4,940 European ancestry controls
430 European ancestry cases, 3,133 European ancestry controls, 90 Nepalese ancestry cases, 205 Nepalese ancestry controls, 2,340 East Asian ancestry cases, 3,865 East Asian ancestry controls, 628 South Asian ancestry cases, 552 South Asian ancestry controls, 99 Latin American cases, 224 Latin American controls, 391 Saudi Arabian ancestry cases, 1,659 Saudi Arabian ancestry controls
1,658 European ancestry child cases, 7,224 European ancestry controls
1,109 child cases, 1,412 European ancestry child cases, 2,085 controls, 1,479 European ancestry controls
Breast cancer-free interval (treatment with aromatase inhibitor)
6 African American recurrent cases, 134 African American controls without recurrence, 243 European ancestry recurrent cases, 4,216 European ancestry controls without recurrence, 3 Asian ancestry recurrent cases, 56 Asian ancestry controls without recurrence
2,672 European ancestry cases, 1,776 European ancestry controls
1,226 European ancestry cases, 1,392 European ancestry controls
Mosaic loss of chromosome Y
895 cases, 11,474 controls
Hair shape
16,763 European ancestry individuals
2,340 European ancestry individuals, 2,899 Han Chinese ancestry individuals, 709 Uyghur ancestry individuals, 6,238 Latin American individuals, 15 South American, South Asian or Middle Eastern individuals
Male sexual orientation
1,077 European ancestry homosexual men, 1,231 European ancestry heterosexual men
Moyamoya disease
755 Han Chinese ancestry cases, 2,031 Han Chinese ancestry controls
724 Han Chinese ancestry cases, 3,043 Han Chinese ancestry controls
Mortality in sepsis
149 European ancestry cases, 591 European ancestry controls
up to 2,534 individuals
Risky sexual behaviors (alcohol dependence interaction)
454 African American women cases, 1,087 African American men cases, 444 European ancestry women cases, 992 European ancestry men cases, 231 African American women controls, 401 African American men controls, 142 European ancestry women controls, 173 European ancestry men controls
Risky sexual behaviors in alcohol dependence
454 African American women individuals, 1,087 African American men individuals, 444 European ancestry women individuals, 992 European ancestry men individuals.
1,216 European ancestry cases, 3,791 European ancestry controls
527 European ancestry cases, 663 European ancestry controls
up to 586,626 European ancestry individuals, up to 19,433 African ancestry individuals
Affymetrix, Illumina [at least 13643373] (imputed)
Chronic rhinosinusitis with nasal polyps
406 European ancestry cases, 376 European ancestry controls (first degree relatives)
23,127 European ancestry individuals
928 European ancestry individuals
Core binding factor acute myeloid leukemia
175 European ancestry cases, 218 European ancestry controls
Overall survival in osteosarcoma
523 European ancestry individuals
109 Brazilian ancestry individuals
Bipolar disorder lithium response (continuous) or schizophrenia
2,366 European ancestry lithium treated bipolar disorder cases, 220 Asian ancestry lithium treated bipolar disorder cases, 36,989 schizophrenia cases, controls (see Ripke et al 2014 PMID:25056061)
Bipolar disorder lithium response (categorical) or schizophrenia
704 European and East Asian ancestry lithium responder bipolar disorder cases, 1,662 European and East Asian ancestry lithium non-responder bipolar disorder controls, 36,989 schizophrenia cases, controls (see Ripke 2014 PMID:25056061).
Inhibitory control
Food addiction
up to 9,314 European ancestry individuals
Affymetrix, Illumina [~ 31000000] (imputed)
Selective IgA deficiency
1,635 European ancestry cases, 4,852 European ancestry controls
Response to mepolizumab in severe asthma
820 European ancestry individuals
282 Japanese ancestry cases, 426 Japanese ancestry controls
320 Japanese ancestry cases, 1,622 Japanese ancestry controls
15,126 European ancestry cases, 95,725 European ancestry controls
30,770 European ancestry cases, 286,913 European ancestry controls
Affymetrix, Illumina [6864281] (imputed)
1,167 European ancestry post-term-born individuals, 3,625 European ancestry term-born individuals
329,821 European ancestry individuals
56,819 European ancestry individuals, 5,748 Hispanic/Latino individuals, 5,119 East Asian ancestry individuals, 2,070 African American individuals
37,930 European and Asian ancestry individuals
259 European ancestry cases, 401 European ancestry controls
276 French cases, 184 European ancestry controls
Response to metformin in type 2 diabetes (HbA1c reduction)
1,372 European ancestry individuals
9,184 European ancestry individuals, 1,196 African American ancestry individuals, 627 Asian American individuals, 743 Latino individuals
27,581 European ancestry individuals
6,393 individuals
Affymetrix, Illumina [2725778] (imputed)
Lower body strength
9,822 European ancestry individuals
Forced expiratory volume in 1 second (environmental tobacco smoke interaction)
10,817 European ancestry individuals
1,156 European ancestry individuals, 1,276 individuals
7,319 European ancestry cases, 234,385 European ancestry controls
2,547 European ancestry cases, 4,803 European ancestry controls
6,353 South Asian ancestry cases, 7,179 South Asian ancestry controls, 3,871 European ancestry cases, 16,427 European ancestry controls, 34,840 cases, 114,981 controls
7,888 South Asian ancestry cases, 20,679 South Asian ancestry controls, 387 European ancestry cases, 2,092 European ancestry controls, 19,998 East Asian ancestry cases, 30,983 East Asian ancestry controls
Alzheimer's disease or type 2 diabetes (pleiotropy)
17,008 European ancestry Alzheimer's disease cases, 12,171 European ancestry type II diabetes cases, 94,016 European ancestry controls
529 Japanese ancestry cases, 521 Japanese ancestry controls
1,269 Japanese ancestry cases, 2,104 Japanese ancestry controls
1,181 Japanese ancestry cases, 1,617 Japanese ancestry controls
Opioid requirements during laparoscopic-assisted colectomy
117 Japanese ancestry patients
234 Japanese ancestry patients
Sotalol-induced IKr potassium channel inhibition (T wave peak and end interval change)
448 European ancestry individuals, 47 North African ancestry individuals
431 European ancestry individuals, 64 North African ancestry individuals
Sotalol-induced IKr potassium channel inhibition (T wave maximal amplitude change)
Sotalol-induced IKr potassium channel inhibition (ventricular repolarization duration change)
Sotalol-induced IKr potassium channel inhibition (ventricular repolarization changes PC2)
Sotalol-induced IKr potassium channel inhibition (ventricular repolarization changes PC3)
Sotalol-induced IKr potassium channel inhibition (ventricular repolarization changes PC1)
Sotalol-induced IKr potassium channel inhibition (T wave morphology notching)
12,577 European ancestry cases, 23,475 European ancestry controls
2,579 European ancestry cases, 2,767 European ancestry controls
Response to cognitive-behavioural therapy in anxiety disorder
Up to 902 European ancestry cases, up to 78 cases
325 Korean ancestry cases, 2,603 Korean ancestry controls
227 Korean ancestry cases, 229 Korean ancestry controls
8,372 Finnish ancestry males
Ratio of apolipoprotein A1 to apolipoprotein B
Esterified cholesterol levels
Free cholesterol levels
Total cholesterol levels in HDL
Total cholesterol levels in LDL
Mean diameter of HDL particles
Mean diameter of LDL particles
Mean diameter of VLDL particles
Very large VLDL particle concentration
Phospholipid levels in very large VLDL
Triglyceride levels in very large VLDL
Phospholipid levels in large VLDL
Total cholesterol levels in large VLDL
Free cholesterol levels in large VLDL
Triglyceride levels in large VLDL
Cholesterol ester levels in large VLDL
Medium VLDL particle concentration
Phospholipid levels in medium VLDL
Total cholesterol levels in medium VLDL
Cholesterol ester levels in medium VLDL
Free cholesterol levels in medium VLDL
337 African American allergic asthma cases, 321 African American non-allergic asthma cases, 1,367 African American controls, 466 European American allergic asthma cases, 626 European American non-allergic asthma cases, 7,878 European American controls
819 African American non-allergic asthma cases, 2,218 African American allergic asthma cases 4,360 African American controls, 808 European American non-allergic asthma cases, 1,464 European American allergic asthma cases, 11,975 European American controls
1,181 African American allergic asthma child cases, 498 African American non-allergic asthma child cases, 2,993 African American child controls, 998 European American allergic asthma child cases, 182 European American non-allergic asthma child cases, 4,097 European American child controls.
Triglyceride levels in medium VLDL
Small VLDL particle concentration
Phospholipid levels in small VLDL
Total cholesterol levels in small VLDL
Free cholesterol levels in small VLDL
Triglyceride levels in small VLDL
Very small VLDL particle concentration
Phospholipid levels in very small VLDL
Triglyceride levels in very small VLDL
IDL particle concentration
Phospholipid levels in IDL
Free cholesterol levels in IDL
Triglyceride levels in IDL
Large LDL particle concentration
Phospholipid levels in large LDL
Total cholesterol levels in large LDL
Cholesterol ester levels in large LDL
Free cholesterol levels in large LDL
Medium LDL particle concentration
Phospholipid levels in medium LDL
Total cholesterol levels in medium LDL
Cholesterol ester levels in medium LDL
Small LDL particle concentration
Total cholesterol levels in small LDL
up to 16,097 European ancestry cases, up to 18,077 European ancestry controls
up to 20,693 European ancestry cases, up to 30,266 European ancestry controls
746 African American cases, 2,825 African American controls, 743 East Asian ancestry cases, 3,992 East Asian ancestry controls, 7,111 European ancestry cases, 49,688 European ancestry controls, 1,147 Latino cases, 5,352 Latino controls
12,171 European ancestry cases, 56,862 European ancestry controls
Epstein-Barr virus copy number in lymphoblastoid cell lines
389 East Asian ancestry individuals, 189 South Asian ancestry individuals, 492 European ancestry individuals, 467 Sub-Saharan African ancestry individuals, 59 African American individuals, 157 Hispanic/Latino individuals
Family history of upper gastrointestinal cancer in esophageal squamous cell carcinoma
1,034 East Asian ancestry cases with family history of upper gastrointestinal cancer, 2,268 East Asian ancestry cases without family history of upper gastrointestinal cancer
up to 2,801 East Asian ancestry cases with family history of upper gastrointestinal cancer, 3,136 East Asian ancestry cases without family history of upper gastrointestinal cancer
HER2 status in breast cancer
5,473 European ancestry HER2-negative cases, 3,230 European ancestry HER2-positive cases
Lumbar spondylosis (disc space narrowing)
228 Korean ancestry cases, 1197 Korean ancestry controls
Lumbar spondylosis (presence and severity of osteophytes)
762 Korean ancestry cases, 664 Korean ancestry controls
Lumbar spondylosis (Kellgren-Lawrence grade)
1,029 Korean ancestry cases, 395 Korean ancestry controls
Sarcoidosis (non-Lofgren's syndrome)
568 Swedish ancestry cases, 2,025 Swedish ancestry controls
763 European ancestry cases, 4,901 European ancestry controls, 781 African American ancestry cases, 876 African American ancestry controls
Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations)
451 Swedish ancestry cases, 2,086 Swedish ancestry controls
Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome)
664 Swedish ancestry non-Lofgren's syndrome cases, 384 Swedish ancestry Lofgren's syndrome cases
413 German ancestry non-Lofgren's syndrome cases, 64 German ancestry Lofgren's syndrome cases
Sarcoidosis (Lofgren's syndrome)
345 Swedish ancestry cases, 2,025 Swedish ancestry controls
251 European ancestry cases, 4,901 European ancestry controls
Serum uric acid levels in response to allopurinol in gout
1,607 European ancestry individuals, 238 East Asian individuals, 84 African American individuals, 85 Hispanic individuals, 13 individuals
Obsessive-compulsive disorder or autism spectrum disorder
2,998 European ancestry obsessive-compulsive disorder cases, 6,898 European ancestry autism spectrum disorder cases
Differentiated thyroid cancer
470 Korean ancestry cases, 8,279 Korean ancestry controls
615 Korean ancestry cases, 605 Korean ancestry controls
Affymetrix, Illumina [3593389] (imputed)
Papillary thyroid cancer
410 Korean ancestry cases, 8,279 Korean ancestry controls
587 Korean ancestry cases, 605 Korean ancestry controls
Follicular thyroid cancer
60 Korean ancestry cases, 8,279 Korean ancestry controls
28 Korean ancestry cases, 605 Korean ancestry controls
Immunoglobulin A vasculitis
285 European ancestry cases, 1,006 European ancestry controls
Huntington's disease progression
1,989 European and unknown ancestry mutation carriers
240 French Canadian ancestry cases, 120 French Canadian ancestry controls
342 French Canadian ancestry cases, 213 European ancestry cases, 261 French Canadian ancestry controls, 142 European ancestry controls
Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer
50 European ancestry cases with neuropathy, 573 European ancestry cases without neuropathy
14 Black cases, 922 European ancestry cases, 25 cases, 82 Black controls, 3,918 European ancestry controls, 129 controls
Very large HDL particle concentration
Phospholipid levels in very large HDL
Total cholesterol levels in very large HDL
Cholesterol ester levels in very large HDL
Free cholesterol levels in very large HDL
Triglyceride levels in very large HDL
Large HDL particle concentration
Phospholipid levels in large HDL
Total cholesterol levels in large HDL
Free cholesterol levels in large HDL
Medium HDL particle concentration
Phospholipid levels in medium HDL
Total cholesterol levels in medium HDL
Cholesterol ester levels in medium HDL
Free cholesterol levels in medium HDL
Small HDL particle concentration
Triglyceride levels in small HDL
Chylomicron and largest VLDL particle concentration
Phospholipid levels in chylomicrons and largest VLDL
Triglyceride levels in chylomicrons and largest VLDL
Mortality in heart failure
1798 European ancestry cases, 1030 European ancestry controls
889 European ancestry cases, 981 European ancestry controls
Pre bronchodilator FEV1/FVC ratio in never-smokers
5,070 European ancestry individuals
1,966 European ancestry individuals
812 African American child cases, 415 African American child controls
Post bronchodilator FEV1 in COPD
5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases
Post bronchodilator FEV1/FVC ratio
10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Post bronchodilator FEV1
Post bronchodilator FEV1/FVC ratio in COPD
Pre bronchodilator FEV1
6,659 European ancestry current and former smoker individuals
Pre bronchodilator FEV1/FVC ratio
Neovascular age-related macular degeneration
377 Thai ancestry cases, 1,074 Thai ancestry controls
222 Thai ancestry cases, 623 Thai ancestry controls
1,886 European ancestry cases, 10,421 European ancestry controls
Brain volume in infants (white matter)
295 European, African American, Asian, Native American and other admixed ancestry infants, 17 European, African American, Asian, Native American and other admixed ancestry sibling pairs, 116 European, African American, Asian, Native American and other admixed ancestry twin pairs.
Brain volume in infants (cerebrospinal fluid)
Brain volume in infants (grey matter)
Brain volume in infants (intracranial brain volume)
Lumbar spine bone mineral density or coronary artery disease (pleiotropy)
53,236 individuals with bone mineral density measurements, 22,233 coronary artery disease cases, 64,762 controls
862 Native American ancestry-enriched North American cases, 531 Native American ancestry-enriched South American cases, 1,973 Native American ancestry-enriched North American controls, 344 Native American ancestry-enriched South American controls
4,629 African American individuals, 5,131 European ancestry individuals
801 African American individuals, 1,746 European ancestry individuals
2,415 African American cases, 1,798 African American controls, 2,669 European ancestry cases, 2,002 European ancestry controls
324 African American cases, 327 African American controls, 2,269 European ancestry cases, 2,975 European ancestry controls
4,896 European ancestry individuals
Affymetrix, Illumina [up to 1078289] (imputed)
1,811 Taiwanese Han Chinese ancestry cases, 8,489 Taiwanese Han Chinese ancestry controls
1,811 Taiwanese Han Chinese individuals with metabolic syndrome, 8,489 Taiwanese Han Chinese ancestry individuals without metabolic syndrome
Matrix metalloproteinase-8 levels
6,049 Finnish ancestry individuals
15,997 Hispanic/Latino individuals
Affymetrix, Illumina [up to 17586686] (imputed)
10,318 South Asian ancestry individuals
1,922 South Asian ancestry individuals
Affymetrix, Illumina, Perlegen [6571328] (imputed)
Response to metformin (IC50)
up to 96 African American lymphoblastoid cell lines, up to 96 Han Chinese American lymphoblastoid cell lines, up to 96 European ancestry lymphoblastoid cell lines
Affymetrix, Illumina [~ 6700000] (imputed)
Survival in head and neck cancer
489 European ancestry cases, 26 Asian, African or First Nation ancestry cases
470 European ancestry cases, 57 Asian ancestry cases, 11 African American ancestry cases, 28 other ancestry cases
Cognitive ability
107,207 European ancestry individuals
Affymetrix, Illumina [7357080] (imputed)
Cognitive ability (MTAG)
436,124 European ancestry individuals
Affymetrix, Illumina, Perlegen [7333576] (imputed)
Caudate volume in trauma-exposed individuals
36 African American post-traumatic stress disorder cases, 38 African American trauma-exposed controls, 30 European ancestry post-traumatic stress disorder cases, 53 European ancestry trauma-exposed controls
Nucleus accumbens volume in trauma-exposed individuals
Pallidum volume in trauma-exposed individuals
Amygdala volume in trauma-exposed individuals
Hippocampal volume in trauma-exposed individuals
Putamen volume in trauma-exposed individuals
Lateral ventricle volume in trauma-exposed individuals
Thalamus volume in trauma-exposed individuals
Mood instability
53,525 European ancestry cases, 60,443 European ancestry controls
43,660 European ancestry cases without a psychiatric disorder diagnosis, 60,443 European ancestry controls
1,593 East Asian ancestry cases, 2,816 East Asian ancestry controls
744 East Asian ancestry cases, 1,137 East Asian ancestry controls
Tanning
216 Sub-Saharan African ancestry individuals
240 Sub-Saharan African ancestry individuals
2,605 European ancestry cases, 16,168 European ancestry controls
8,508 European ancestry cases, 16,527 European ancestry controls
Early gestational weight gain (fetal effect)
up to 8,559 European ancestry fetuses
up to 3,289 European ancestry fetuses
Gestational weight gain (fetal effect)
up to 16,434 European ancestry fetuses
up to 7,827 European ancestry fetuses
Late gestational weight gain (fetal effect)
up to 8,641 European ancestry fetuses
up to 779 European ancestry fetuses
Early gestation weight gain (maternal effect)
up to 7,704 European ancestry mothers
up to 1,584 European ancestry mothers
Late gestational weight gain (maternal effect)
up to 7,681 European ancestry mothers
up to 1,646 European ancestry mothers
Gestational weight gain (maternal effect)
up to 10,555 European ancestry mothers
up to 11280 European ancestry mothers
Methotrexate-induced interstitial lung disease in rheumatoid arthritis
62 European ancestry cases, 175 European ancestry controls
2,853 European ancestry cases and 37,405 European ancestry controls
1,827 European ancestry cases and 2,181 European ancestry controls
Cardiometabolic and hematological traits
up to 35,981 European ancestry individuals
up to 102,505 European ancestry individuals
Affymetrix, Illumina [17000000] (imputed)
Branched-chain amino acid levels (Isoleucine)
16,596 European ancestry individuals
Affymetrix, Illumina [10500000] (imputed)
Branched-chain amino acid levels (Leucine)
Branched-chain amino acid levels (Valine)
Progranulin levels
1,963 European ancestry individuals, 848 Sorbian (founder/genetic isolate) individuals
1800 European ancestry individuals
6,307 Sardinian (founder/population isolate) individuals
5,314 Sardinian (founder/population isolate) individuals, 19,053 European ancestry individuals
Common carotid intima-media thickness in HIV negative individuals
288 Black non-Hispanic HIV-negative women
Common carotid intima-media thickness in HIV infection
682 Black non-Hispanic HIV-positive women
Common carotid intima-media thickness
682 Black non-Hispanic HIV-positive women, 288 Black non-Hispanic HIV-negative women
Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy
852 European ancestry cases
685 European ancestry cases
Dupuytren's disease
3,871 European ancestry cases, 4,686 European ancestry controls
4,041 European and unknown ancestry cases, 8,251 European and unknown ancestry controls
Subjective response to lithium treatment
1,639 European ancestry bipolar disorder responder cases, 8,899 European ancestry controls
Affymetrix, Illumina [> 8000000] (imputed)
Subjective response to lithium treatment in bipolar disorder
1,639 European ancestry responder cases, 1,059 European ancestry non-responder cases
Objective response to lithium treatment
323 European ancestry bipolar disorder responder cases, 6,684 European ancestry controls
Objective response to lithium treatment in bipolar disorder
323 European ancestry responder cases, 853 European ancestry non-responder cases
5,851 European ancestry cases, 5,866 European ancestry controls
260 European ancestry cases, 190 African-American cases, 745 Hispanic cases, 131 East Asian ancestry cases, 23 South East Asian ancestry cases, 9,630 European ancestry controls, 1,684 African-American controls, 1,102 Hispanic controls, 118 East Asian ancestry controls, 36 South East Asian ancestry controls
145 African American cases, 307 Latino cases, 82 European ancestry cases, 1,274 African American controls, 2,826 Hispanic / Latino controls, 249 European ancestry controls
Visceral adipose tissue (sex interaction)
580 Mexican American female individuals, 403 Mexican American male individuals.
365 Mexican American female individuals, 342 Mexican American male individuals
Subcutaneous adipose tissue (sex interaction)
Visceral adipose tissue/subcutaneous adipose tissue ratio (sex interaction)
Visceral adipose tissue adjusted for BMI (sex interaction)
P wave terminal force
33,955 European ancestry individuals, 6,778 African individuals
Affymetrix, Illumina [at least 2402234] (imputed)
37,678 European ancestry individuals, 6,778 African ancestry individuals
High altitude adaptation
3,008 Tibetan (founder/genetic isolate) individuals and 7,287 East Asian individuals
18,900 European ancestry cases, 1,472 Japanese ancestry cases, 422 African American cases, 300 Latino cases, 305 cases, 84,166 European ancestry controls, 7,966 Japanese ancestry controls, 844 African American controls, 1,592 Latino controls, 896 controls
30,588 European ancestry cases, 459 African American cases, 1,012 Chinese ancestry cases, 226,537 European ancestry controls, 729 African American controls, 1,362 Chinese ancestry controls
142,035 European ancestry individuals
53,145 European ancestry individuals
Affymetrix [at least 17000000] (imputed)
Fat mass index
12,851 individuals
Estradiol levels
11,097 European ancestry men
Estrone levels
7,570 European ancestry men
Frontotemporal dementia and immune-mediated diseases (pleiotropy)
2,154 frontotemporal dementia cases, 4,308 controls, 51,109 Crohn's disease cases and controls, 26,405 ulcerative colitis cases and controls, 25,708 rheumatoid arthritis cases and controls, 16,559 type 1 diabetes cases and controls,15,283 celiac disease cases and controls, 7,484 psoriasis cases and controls
Progressive supranuclear palsy and immune-mediated diseases (pleiotropy)
1,114 progressive supranuclear palsy cases, 3,247 controls, 51,109 Crohn's disease cases and controls, 26,405 ulcerative colitis cases and controls, 25,708 rheumatoid arthritis cases and controls, 16,559 type 1 diabetes cases and controls,15,283 celiac disease cases and controls, 7,484 psoriasis cases and controls
Amyotrophic lateral sclerosis and immune-mediated diseases (pleiotropy)
12,577 amyotrophic lateral sclerosis cases, 23,475 controls, 51,109 Crohn's disease cases and controls, 26,405 ulcerative colitis cases and controls, 25,708 rheumatoid arthritis cases and controls, 16,559 type 1 diabetes cases and controls,15,283 celiac disease cases and controls, 7,484 psoriasis cases and controls
Corticobasal degeneration and immune-mediated diseases (pleiotropy)
152 corticobasal degeneration cases, 3,311 controls, 51,109 Crohn's disease cases and controls, 26,405 ulcerative colitis cases and controls, 25,708 rheumatoid arthritis cases and controls, 16,559 type 1 diabetes cases and controls,15,283 celiac disease cases and controls, 7,484 psoriasis cases and controls
Response to ranibizumab in age-related macular degeneration (visual acuity)
256 Japanese ancestry treated individuals
205 Japanese ancestry treated individuals
Response to ranibizumab in age-related macular degeneration (additional treatment requirement)
Response to ranibizumab in age-related macular degeneration (dry maculae)
Cirrhosis (alcohol related)
712 European ancestry cases, 1,426 European ancestry alchocol dependent controls
1,148 European ancestry cases, 922 European ancestry alchocol dependent controls
171 European ancestry cases, 2,934 European ancestry controls
2,866 European ancestry cases, 6,481 European ancestry controls
Disease-free survival in breast cancer treated with chemotherapy with or without bevacizumab
890 cases
1,398 cases
Overall survival in breast cancer treated with chemotherapy with or without bevacizumab
891 cases
1,398 individuals
Pathological complete response in breast cancer treated with chemotherapy with bevacizumab
147 cases with pathological complete response, 300 cases without pathological complete response
142 cases with pathological complete response, 591 cases without pathological complete response
Pathological complete response in breast cancer treated with or without bevacizumab
236 cases with pathological complete response, 678 cases without pathological complete response
254 cases with pathological complete response, 1,144 cases without pathological complete response
Antiepileptic drug-induced maculopapular exanthema
259 European ancestry cases, 979 European ancestry tolerant controls, 116 Han Chinese ancestry cases, 342 Han Chinese ancestry tolerant controls
Carbamazepine-induced maculopapular exanthema
95 European ancestry cases, 869 European ancestry tolerant controls, 85 Han Chinese ancestry cases, 197 Han Chinese ancestry tolerant controls
Lamotrigine-induced maculopapular exanthema
118 European ancestry cases, 812 European ancestry tolerant controls, 16 Han Chinese ancestry cases, 32 Han Chinese ancestry tolerant controls
Phenytoin-induced maculopapular exanthema
52 European ancestry cases, 472 European ancestry tolerant controls, 22 Han Chinese ancestry cases, 58 Han Chinese ancestry tolerant controls
13 European ancestry cases, 88 European ancestry tolerant controls
1,778 Chinese ancestry cases, 391 Malay ancestry cases, 5,164 Chinese ancestry controls, 2,212 Malay ancestry controls
291 Asian Indian cases, 1,848 Asian Indian controls
76,067 European ancestry women, 66,420 European ancestry men
Laterality in neovascular age-related macular degeneration
803 Japanese ancestry unilateral cases, 321 Japanese ancestry bilateral cases
132 Japanese ancestry unilateral cases, 36 Japanese ancestry bilateral cases, 78 Asian ancestry unilateral cases, 24 Asian ancestry bilateral cases
1,068 European ancestry cases, 3,327 European ancestry controls, 514 cases, 2,119 controls
1,170 European ancestry cases, 3,336 European ancestry controls, up to 6,098 cases, up to 25,748 controls
Alcoholic hepatitis
90 European ancestry heavy drinking cases, 93 European ancestry heavy drinking controls
Thiazide-induced hyponatremia
48 European ancestry cases, 2,905 European ancestry controls
94 European ancestry cases, 106 European ancestry controls
6,337 European ancestry cases, 61,607 European ancestry controls
30,679 European ancestry cases, 278,895 European ancestry controls
1,473 Ugandan ancestry individuals, 2,162 European ancestry individuals
Epstein Barr virus nuclear antigen 1 IgG seropositivity
1,201 Ugandan ancestry cases, 361 Ugandan ancestry controls
Viral capsid antigen IgG levels
1,473 Ugandan ancestry individuals
Viral capsid antigen IgG seropositivity
1,344 Ugandan ancestry cases, 218 Ugandan ancestry controls
Epstein-Barr virus immune response (multivariate analysis)
Giant cell arteritis
1,651 European ancestry cases, 15,306 European ancestry controls
68,258 European ancestry women
18,319 European ancestry women
Affymetrix, Illumina, Perlegen [up to 8741107] (imputed)
1,833 European ancestry cases, 3,466 European ancestry controls, 291 African American cases, 260 African American controls
1,087 European ancestry cases, 3,466 European ancestry controls, 82 African American cases, 260 African American controls
574 European ancestry cases, 3,466 European ancestry controls, 201 African American cases, 260 African American controls
Systemic sclerosis (anti-centromere-positive)
671 European ancestry cases, 3,466 European ancestry controls, 21 African American cases, 260 African American controls
Systemic sclerosis (anti-topoisomerase-positive)
347 European ancestry cases, 3,466 European ancestry controls, 69 African American cases, 260 African American controls
3,555 Swedish ancestry cases, 15,581 Swedish ancestry controls
19,809 European ancestry cases, 111,181 European ancestry controls
6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls
Acute respiratory distress syndrome
232 African American ancestry cases, 162 African American ancestry controls with sepsis or other risk factors
140 African American cases, 269 European ancestry cases, 222 African American ancestry controls with sepsis, 338 European ancestry controls with sepsis
Neutralising antibody response to interferon beta therapy in multiple sclerosis (time to production)
361 European, Hispanic, Asian, African or unknown ancestry cases
Neutralising antibody response to interferon beta therapy in multiple sclerosis (presence of antibodies)
361 European, Hispanic, Asian, African or unknown ancestry cases, 580 European, Hispanic, Asian, African or unknown ancestry controls
Neutralising antibody response to interferon beta therapy in multiple sclerosis (mean antibody levels)
926 European ancestry individuals, 7 Hispanic individuals, 1 Asian ancestry individuals, 1 African ancestry individual, 4 other unknown ancestry individuals, 2 individuals
Neutralising antibody response to interferon beta therapy in multiple sclerosis (area under the curve for the first two years)
Neutralising antibody response to interferon beta therapy in multiple sclerosis (maximum antibody levels)
up to 2,737 cases, up to 4,752 controls
Premature menopause in childhood cancer survivors
27 European ancestry cases, 3 African ancestry cases, 658 European ancestry controls, 111 African ancestry controls
2,971 European ancestry individuals, 165 individuals
Survival in endocrine treated breast cancer (estrogen-receptor positive)
2,629 European ancestry individuals, 122 individuals
348 Chinese ancestry carrier cases, 359 Chinese ancestry carrier controls, 189 Chinese ancestry trios
3,796 Chinese ancestry carrier cases, 2,544 Chinese ancestry carrier controls
Affymetrix, Illumina [up to 6089459] (imputed)
60 Finnish ancestry cases, 114 Finnish ancestry controls
234 European ancestry cases, 25 African ancestry cases, 633 European ancestry controls, 51 African ancestry controls
14,498 European ancestry cases, 24,091 European ancestry controls
14,802 European ancestry cases, 26,703 European ancestry controls
Thiopurine-induced leukopenia in inflammatory bowel disease
113 Korean ancestry cases, 154 Korean ancestry controls
245 East Asian ancestry cases, 522 East Asian ancestry controls
Curve progression in adolescent idiopathic scoliosis
1,105 Japanese ancestry AIS progression cases, 832 Japanese ancestry AIS non-progression controls
323 Japanese ancestry AIS progression cases, 283 Japanese ancestry AIS non-progression controls
Ankle injury
1,421 European ancestry cases, 154 Hispanic/Latino cases, 121 East Asian ancestry cases, 81,843 European ancestry controls, 8,406 Hispanic/Latino controls, 7,397 East Asian ancestry controls
71,701 Japanese ancestry individuals
Phosphorus levels
42,793 Japanese ancestry individuals
110,207 Japanese ancestry individuals
136,597 Japanese ancestry individuals
136,615 Japanese ancestry individuals
136,482 Japanese ancestry individuals
136,249 Japanese ancestry individuals
Left ventricular internal dimension in diastole
19,676 Japanese ancestry individuals
Left ventricular internal dimension in systole
19,586 Japanese ancestry individuals
Relative wall thickness
19,311 Japanese ancestry individuals
Fractional shortening
19,580 Japanese ancestry individuals
Ejection fraction
19,516 Japanese ancestry individuals
Interventricular septum thickness
19,318 Japanese ancestry individuals
Posterior wall thickness
19,373 Japanese ancestry individuals
19,076 Japanese ancestry individuals
Left ventricular mass index
17,837 Japanese ancestry individuals
E/A ratio
8,600 Japanese ancestry individuals
70,657 Japanese ancestry individuals
72,866 Japanese ancestry individuals
105,597 Japanese ancestry individuals
Blood sugar levels
93,146 Japanese ancestry individuals
42,790 Japanese ancestry individuals
Immunoglobulin measurement (zinc sulfate turbidity test)
12,303 Japanese ancestry individuals
134,154 Japanese ancestry individuals
134,182 Japanese ancestry individuals
5,107 European ancestry cases, 8,845 European ancestry controls
6,076 cases, 7,555 controls
1,701 Finnish ancestry cases, 14,082 Finnish ancestry controls
11,647 European ancestry cases, 12,356 European ancestry controls
1,505 Korean ancestry cases, 4,041 Korean ancestry controls
1,989 Korean ancestry cases, 3,491 Korean ancestry controls
311 European ancestry cases, 83 African cases, 79 Hispanic/Latino cases, 6,228 European ancestry controls, 1,689 African controls, 1,861 Hispanic/Latino controls
89 European ancestry cases, 17 African cases, 29 Hispanic/Latino cases, 4,594 European ancestry controls, 823 African controls, 1,462 Hispanic/Latino controls
105,030 Japanese ancestry individuals
118,309 Japanese ancestry individuals
37,767 Japanese ancestry individuals
58,110 Japanese ancestry individuals
18,348 Japanese ancestry individuals
106,080 Japanese ancestry individuals
126,319 Japanese ancestry individuals
75,391 Japanese ancestry individuals
Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines
up to 407 European ancestry cases, up to 138 African ancestry cases, up to 251 Hispanic cases, up to 57 Asian ancestry cases, up to 110 other ancestry cases
26,320 European ancestry individuals, 2,868 whole genome sequenced European ancestry individuals, 3,547 whole exome sequenced European ancestry individuals
17,253 European ancestry individuals
23,699 European ancestry individuals, 1,526 whole genome sequenced European ancestry individuals, 3,273 whole exome sequenced European ancestry individuals
16,233 European ancestry individuals
Forearm bone mineral density
6,627 European ancestry individuals, 1,221 whole genome sequenced European ancestry individuals, 295 whole exome sequenced European ancestry individuals,
2,662 European ancestry individuals
Cranial base width
2,447 European ancestry individuals
671 European ancestry individuals
Eye morphology
Nose morphology
Lip morphology
Lower facial height
Facial depth
Parkinson's disease (pesticide exposure interaction)
364 cases, 364 sibling controls
2,675 Han Chinese ancestry cases, 224 Han Chinese ancestry controls
357 Uyghur ancestry cases, 352 Uyghur ancestry controls
107,964 Japanese ancestry individuals
62,076 Japanese ancestry individuals
108,794 Japanese ancestry individuals
108,769 Japanese ancestry individuals
108,757 Japanese ancestry individuals
108,256 Japanese ancestry individuals
108,054 Japanese ancestry individuals
108,728 Japanese ancestry individuals
108,208 Japanese ancestry individuals
Non-albumin protein levels
98,538 Japanese ancestry individuals
113,509 Japanese ancestry individuals
102,223 Japanese ancestry individuals
Albumin-globulin ratio
98,626 Japanese ancestry individuals
139,818 Japanese ancestry individuals
142,097 Japanese ancestry individuals
143,658 Japanese ancestry individuals
109,029 Japanese ancestry individuals
127,304 Japanese ancestry individuals
132,938 Japanese ancestry individuals
126,402 Japanese ancestry individuals
12.945 European ancestry cases, 274,252 European ancestry controls
4,242 European ancestry cases, 12,802 European ancestry controls
10,554 European ancestry children
1,250 European ancestry children
Affymetrix, Illumina [at least 5306521] (imputed)
Migraine or coronary artery disease
37,653 coronary artery disease cases, 22,120 migraine cases, 171,108 controls
128,305 Japanese ancestry individuals
Acute kidney injury in critical illness
709 European ancestry cases, 619 European ancestry controls
206 European ancestry cases, 1,406 European ancestry controls
up to 13,838 European ancestry cases, up to 33,742 European ancestry controls
3,297 European ancestry cases, 15,870 European ancestry controls
up to 9,585 European ancestry cases, up to 33,742 European ancestry controls
1,005 Han Chinese ancestry cases, 1,053 Han Chinese ancestry controls
1,120 Han Chinese ancestry cases, 604 Han Chinese ancestry controls
370 Carlantino (founder/genetic isolate) individuals, 843 Friuli Venezia Giulia (founder/genetic isolate) individuals
1,731 Erasmus Rucphen (founder/genetic isolate) individuals
Lumbar spinal stenosis
469 Chinese ancestry individuals
Serum C3d:C3 ratio (systemic complement activation)
up to 1,548 European ancestry individuals
up to 697 European ancestry individuals
Headache
74,461 British ancestry cases, 149,321 British ancestry controls
Intracranial haemorrhage in renal transplantation (donors)
1,304 European ancestry donor cases, 8,784 European ancestry donor, recipient and other controls
2,407 European ancestry donor cases, 2,620 European ancestry donor controls
End stage renal failure in renal transplantation (recipient effect)
2,689 European ancestry recipient cases, 7,399 European ancestry donor and other controls
5,866 European ancestry individuals
Graft survival time in renal transplantation (recipient effect)
up to 2,689 European ancestry individuals
up to 2,204 European ancestry donors
5,027 European ancestry donors
Graft survival time in renal transplantation (donor-recipient interaction)
2,094 European ancestry donor-recipient pairs
5,866 European ancestry donor-recipient pairs
Acute graft rejection in renal transplantation (recipient effect)
441 European ancestry cases, 941 European ancestry controls
575 European ancestry cases, 2,573 European ancestry controls
Acute graft rejection in renal transplantation (donor effect)
414 European ancestry donors (rejection outcome), 825 European ancestry donors (no rejection outcome)
575 European ancestry donors (rejection outcome), 2,573 European ancestry donors (no rejection outcome)
Acute graft rejection in renal transplantation (donor-recipient interaction)
343 European ancestry recipient-donor pair cases, 755 European ancestry recipient-donor pair controls
575 European ancestry recipient-donor pair cases, 2,573 European ancestry recipient-donor pair controls
398 European ancestry bipolar disorder cases, 1,231 European ancestry bipolar disorder controls
398 European ancestry cases, 1,811 European ancestry controls
Response to methylphenidate treatment in attention-deficit/hyperactivity disorder
141 European ancestry responder child cases, 32 European ancestry non-responder child cases
161 Brazilian responder cases, 28 Brazilian non-responder cases
CSF tryptophan concentration in tuberculous meningitis
130 individuals
34,541 cases, 261,984 controls
88,192 cases, 162,544 controls
up to 122,733 cases, up to 424,528 controls
Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia
235 European ancestry cases, 48 African American ancestry cases, 13 cases
Sulfasalazine-induced agranulocytosis
36 European ancestry cases, 5,170 European ancestry untreated controls
1,033 Han Chinese ancestry cases, 950 Han Chinese ancestry controls
1,441 Han Chinese ancestry cases, 1,447 Han Chinese ancestry controls
234 Korean ancestry cases, 3,413 Korean ancestry controls
up to 165,276 European ancestry individuals, up to 27,487 South Asian ancestry individuals
up to 125,713 European ancestry individuals, up to 2,641 South Asian ancestry individuals, 4,632 Hispanic individuals, 22,077 African American individuals
up to 83,330 European ancestry cases, up to 73,760 European ancestry controls, up to 9,322 South Asian ancestry cases, up to 16,861 South Asian ancestry controls
19,954 European ancestry cases, 107,715 European ancestry controls, 2,149 African ancestry cases, 6,055 African ancestry controls, 1,239 Japanese ancestry cases, 3,976 Japanese ancestry controls, 606 Latino cases, 792 Latino controls
Affymetrix, Illumina, Perlegen [2831075] (imputed)
7,131 European ancestry cases, 13,631 European ancestry controls, 1,239 Japanese ancestry cases, 3,976 Japanese ancestry controls, 606 Latino cases, 792 Latino controls
19,954 European ancestry cases, 107,715 European ancestry controls
Heart rate response to exercise
up to 35,455 European ancestry females, up to 31,802 European ancestry males
Heart rate response to recovery post exercise
67,062 European ancestry individuals
ADAMTS13 levels
3,238 European ancestry individuals
GLP-1-stimulated insulin secretion
33 monozygotic twin pairs, 14 dizygotic twin pairs, 32 individuals
100 European ancestry individuals
265,204 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals
76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals
43,861 Japanese ancestry women
32,545 European ancestry women
67,029 Japanese ancestry women
73,397 European ancestry women
Early age at menarche
15,709 Japanese ancestry early age at menarche individuals, 14,557 Japanese ancestry median age at menarche individuals
Late age at menarche
10,875 Japanese ancestry late age at menarche individuals, 14,557 Japanese ancestry median age at menarche individuals
2,619 whole genome sequenced European ancestry individuals, up to 38,213 European ancestry individuals, 1,442 individuals
Affymetrix, Illumina [11026511] (imputed)
Pseudoexfoliation syndrome
103 European ancestry cases, 106 European ancestry controls
1,017 Yoruban ancestry individuals, 1,765 Filipino ancestry individuals
Affymetrix, Illumina [up to 12553142] (imputed)
1,017 Yoruban ancestry individuals,1,765 Filipino ancestry individuals
188,577 European and other ancestry individuals
1,017 Yoruban ancestry individuals, 1,765 Filipino individuals
1,634 Han Chinese ancestry individuals
2,818 Han Chinese ancestry individuals
9,293 European ancestry cases, 12,957 European ancestry controls, 4,349 Asian ancestry cases, 4,771 Asian ancestry controls
203 Mexican American cases, 196 Mexican American controls
3,999 African American cases, 4,764 African American controls
Affymetrix, Illumina [17963051] (imputed)
Cortisol levels (saliva)
7,703 European ancestry individuals
Stimulated C-peptide levels in type I diabetes
1,303 European ancestry individuals
Fasting C-peptide levels in type I diabetes
2,019 European ancestry individuals
Random C-peptide levels in type I diabetes
1,497 European ancestry individuals
C-peptide levels in type I diabetes
3,479 European ancestry individuals
Paternal history of Alzheimer's disease
14,338 British ancestry cases, 245,941 British ancestry controls
up to 42,034 British ancestry individuals with parental history of Alzheimer's disease, at least 272,244 European ancestry individuals with no parental history of Alzheimer's disease
up to 42,034 British ancestry individuals with parental history of Alzheimer's disease, at least 272,244 British ancestry individuals with no parental history of Alzheimer's disease, 25,580 Alzheimer's disease cases, 48,466 controls
Maternal history of Alzheimer's disease
27,696 British ancestry cases, 260,980 British ancestry controls
Coronary artery disease and/or body mass index (pleiotropy)
249,796 European ancestry individuals, 15,420 European and South Asian ancestry coronary artery disease cases, 15,062 European and South Asian controls
22,233 European ancestry cases, 64,762 European controls
diarrhoeal disease at age 1
2,693 European ancestry cases, 3,065 European ancestry controls
2,302 European ancestry cases, 1,466 European ancestry controls
diarrhoeal disease at age 1 with doctor diagnosis
1,339 European ancestry cases, 5,064 European ancestry controls
1,411 European ancestry cases, 6,054 European ancestry controls
Affymetrix, Illumina [at least 5400000] (imputed)
diarrhoeal disease at age 2
2,855 European ancestry cases, 2,753 European ancestry controls
1,972 European ancestry cases, 1,544 European ancestry controls
diarrhoeal disease at age 2 with doctor diagnosis
990 European ancestry cases, 5,243 European ancestry controls
1,274 European ancestry cases, 6,448 European ancestry controls
56,284 European ancestry individuals, up to 1,333 African American individuals, up to 9,328 admixed individuals
Affymetrix, Illumina [~ 23700000] (imputed)
Total body bone mineral density (age 0-15)
11,807 European and unknown ancestry individuals
Total body bone mineral density (age 15-30)
4,180 European and unknown ancestry individuals
Total body bone mineral density (age 30-45)
10,062 European and unknown ancestry individuals
Total body bone mineral density (age 45-60)
18,805 European individuals
Total body bone mineral density (age over 60)
22,504 European ancestry and African American individuals
7,699 Chinese ancestry cases, 35,476 European ancestry cases, 18,327 Chinese ancestry controls, 46,839 European ancestry controls
4,384 Chinese ancestry cases, 5,770 Chinese ancestry controls
Affymetrix, Illumina [up to 5107227] (imputed)
4,785 Han Chinese ancestry cases, 4,814 Han Chinese ancestry controls
Major depressive disorder (exposed to adversity)
1,646 Han Chinese ancestry cases, 982 Han Chinese ancestry controls
Major depressive disorder (unexposed to adversity)
3,139 Han Chinese ancestry cases, 3,832 Han Chinese ancestry controls
170 Danish ancestry cases, 4717 Danish ancestry controls
416 European ancestry cases, 903 European ancestry controls
1,047 Han Chinese ancestry cases, 1,205 Han Chinese ancestry controls
3,509 Han Chinese ancestry cases, 8,246 Han Chinese ancestry controls
Joint destruction and growth retardation
90 East Asian ancestry Kashin-Beck disease cases, 1,627 East Asian ancestry controls
403 East Asian ancestry Kashin-Beck disease cases, 297 East Asian ancestry controls
Autoimmune hepatitis in primary sclerosing cholangitis
107 European ancestry cases, 3,159 European ancestry controls
Primary sclerosing cholangitis (small duct vs large duct)
75 European ancestry small duct cases, 3,159 European ancestry large duct cases
Liver transplant-free survival in primary sclerosing cholangitis (time to event)
874 European ancestry liver transplantation cases , 2,444 European ancestry liver transplant-free cases
Colectomy in primary sclerosing cholangitis
419 European ancestry colectomy cases, 2,897 European non-colectomy controls
Cholangiocarcinoma in primary sclerosing cholangitis
188 European ancestry cases, 3,147 European ancestry controls
Cholangiocarcinoma in primary sclerosing cholangitis (time to event)
188 European ancestry cholangiocarcinoma cases, 3,147 European ancestry cholangiocarcinoma-free cases
Colorectal carcinoma in primary sclerosing cholangitis
127 European ancestry cases, 2,822 European ancestry controls
Gallbladder carcinoma in primary sclerosing cholangitis
30 European ancestry cases, 2,977 European ancestry controls
Hepatocellular carcinoma in primary sclerosing cholangitis
22 European ancestry cases, 2,984 European ancestry controls
Response to antipsychotic treatment in schizophrenia
2,413 Han Chinese ancestry cases
1,379 Han Chinese ancestry cases
Response to haloperidol in schizophrenia
192 Han Chinese ancestry cases
Response to perphenazine in schizophrenia
193 Han Chinese ancestry cases
Response to ziprazidone in schizophrenia
408 Han Chinese ancestry cases
Response to quetiapine in schizophrenia
386 Han Chinese ancestry cases
Response to aripiprazole in schizophrenia
397 Han Chinese ancestry cases
405 Han Chinese ancestry cases
Response to risperidone in schizophrenia
425 Han Chinese ancestry cases
559 Han Chinese ancestry cases
Response to olanzapine in schizophrenia
412 Han Chinese ancestry cases
415 Han Chinese ancestry cases
Decline in glucose metabolism in posterior cingulate cortex
335 European ancestry MCI cases, 79 European ancestry AD cases, 192 European ancestry controls
29,703 British ancestry cases, 86,552 British ancestry controls
35,210 British ancestry cases, 104,263 British ancestry controls
Dimensional psychopathology (Negative)
4,687 Northern European ancestry individuals
Dimensional psychopathology (Positive)
Dimensional psychopathology (Arousal)
Dimensional psychopathology (Social)
Dimensional psychopathology (Cognitive)
2,107 European ancestry individuals
923 Sorbian (founder/genetic isolate) individuals
Hip minimal joint space width
6,523 European ancestry individuals, 6,490 individuals
1,572 European ancestry individuals, 6,655 individuals
Excitement-seeking behaviour
4,375 Sardinian (founder/genetic isolate) individuals, 343 Cilento (founder/genetic isolate) individuals, 3,142 European ancestry individuals
2,062 European ancestry individuals, 3,043 individuals
Affymetrix, Illumina [at least 2000000] (imputed)
Osteoarthritis of the hip or knee (with total joint replacement)
5,414 European ancestry cases, 9,939 European ancestry healthy controls
17,894 European ancestry cases, 89,470 European ancestry healthy controls
12,658 European ancestry cases, 50,898 European ancestry healthy controls
Osteoarthritis of the hip (with total joint replacement)
2,517 European ancestry cases, 9,939 European ancestry healthy controls
2,282 European ancestry cases, 9,193 European ancestry healthy controls
Osteoarthritis of the knee (with total joint replacement)
2,188 European ancestry cases, 9,939 European ancestry healthy controls
2,281 European ancestry cases, 9,194 European ancestry healthy controls
12,310 Hispanic individuals
8,048 Hispanic individuals
N-glycan levels
Up to 1,426 European ancestry male individuals, up to 1,941 European ancestry female individuals
1,553 European ancestry cases, 4,340 European ancestry controls
694 European ancestry cases, 2,105 European ancestry controls, 334 cases, 1,657 controls
Affymetrix, Illumina [2366456] (imputed)
Osteoporosis or obesity (pleiotropy)
53,236 European ancestry individuals (femoral neck BMI), 322,154 European ancestry individuals (BMI), 17,070 individuals (BMI), 210,088 European ancestry individuals (WHR), 14,371 individuals (WHR)
11,245 Han Chinese ancestry cases, 11,177 Han Chinese ancestry controls
6,369 Han Chinese ancestry cases, 13,969 Han Chinese ancestry controls
18 Hispanic cases, 18 Hispanic controls
393 Han Chinese ancestry cases, 393 Han Chinese ancestry controls
4,537 Han Chinese ancestry cases, 4,590 Han Chinese ancestry controls
Early childhood caries
26 African American cases, 34 Hispanic cases, 13 European ancestry cases, 6 Native-American ancestry cases, 1 case, 41 African American controls, 40 Hispanic controls, 36 European ancestry controls, 15 Native-American ancestry controls.
265 cases, 656 controls
12,596 European ancestry individuals
Systemic lupus erythematosus or rheumatoid arthritis
2,237 European ancestry systemic lupus erythematosus cases, 3,911 European ancestry rheumatoid arthritis cases, 10,398 European ancestry controls
1,957 European ancestry systemic lupus erythematosus cases, 13,641 European ancestry rheumatoid arthritis cases, 36,509 European ancestry controls
2,735 East Asian ancestry cases, 590 African American cases, 121 South Asian ancestry cases, 58 South East Asian ancestry cases, 6,410 East Asian ancestry controls, 636 African American controls, 716 South Asian ancestry controls, 1,984 South East Asian ancestry controls
4,773 European ancestry cases, 3,006 East Asian ancestry cases, 497 African American cases, 453 South Asian ancestry cases, 208 South East Asian ancestry cases, 236 Middle East ancestry cases, 11,786 European ancestry controls, 8,754 East Asian ancestry controls, 304 African American controls, 2,496 South Asian ancestry controls, 2,785 South East Asian ancestry controls, 655 Middle East ancestry controls
Mortality
138,536 British ancestry mothers, 133,545 British ancestry fathers
24,168 European ancestry individuals, 681 African ancestry individuals, 962 Afro-Caribbean individuals, 1,613 South Asian ancestry individuals, 338 Chinese ancestry individuals
7,704 Japanese ancestry individuals
Platelet-to-lymphocyte ratio
5,901 Dutch ancestry individuals
2,538 individuals
Affymetrix, Illumina, Perlegen [6010458] (imputed)
Neutrophil-to-lymphocyte ratio
578 Han Chinese ancestry cases, 1,006 Han Chinese ancestry controls
2,828 Han Chinese ancestry cases, 3,639 Han Chinese ancestry controls
Left ventricular QRS voltage
2,941 Japanese ancestry individuals
Fasting growth hormone levels
4,134 Swedish ancestry individuals
5,262 Swedish ancestry individuals
25,662 British ancestry cases, 17,928 British ancestry controls
13,367 European ancestry cases, 11,851 European ancestry controls, 3,436 cases, 2,435 controls
2140 European ancestry cases, 497 African American ancestry cases, 530 Latino American ancestry cases, 2909 European ancestry trauma-exposed controls, 815 African American ancestry trauma-exposed controls, 883 Latino American ancestry trauma-exposed controls.
672 European ancestry cases, 97 African American ancestry cases, 178 Latino American ancestry cases, 3335 European ancestry trauma-exposed controls, 570 African American ancestry trauma-exposed controls, 1064 Latino American ancestry trauma-exposed controls.
Survival in sporadic amyotrophic lateral sclerosis
4,256 European ancestry cases
13 Caucasian Eastern Mediterranean ancestry oligoarticular case-parent trios, 13 Caucasian Eastern Mediterranean ancestry rheumatoid factor negative polyarticular case-parent trios
Primary spontaneous pneumothorax
92 Portuguese ancestry cases, 129 Portuguese ancestry controls
100 Portuguese ancestry cases, 425 Portuguese ancestry controls
12,282 Hispanic ancestry individuals
8,195 Hispanic ancestry individuals
Neurociticism
380,506 European ancestry individuals
Irritable mood
366,726 European ancestry individuals
Feeling lonely
376,352 European ancestry individuals
Feeling miserable
376,097 European ancestry individuals
Experiencing mood swings
373,733 European ancestry individuals
Feeling guilty
373,380 European ancestry individuals
Worry too long after an embarrassing experience
367,725 European ancestry individuals
Feeling fed-up
374,971 European ancestry individuals
Feeling nervous
373,121 European ancestry individuals
Suffering from nerves
369,499 European ancestry individuals
Feeling worry
372,869 European ancestry individuals
Feeling hurt
372,047 European ancestry individuals
Feeling tense
371,318 European ancestry individuals
15,748 European ancestry cases, 18,084 European ancestry controls
46,785 European ancestry cases, 42,892 European ancestry controls
Affymetrix, Illumina [~ 11600000] (imputed)
Affymetrix, Illumina [~ 14000000] (imputed)
6,333 European ancestry cases, 15,056 European ancestry controls
15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios
3,334 European ancestry cases, 4,628 European ancestry controls
14,851 European ancestry cases, 15,569 European ancestry controls
120 Japanese ancestry trios
1,083 East Asian ancestry cases, 1,092 East Asian ancestry controls
15,366 European ancestry individuals
8,463 European ancestry individuals
HIV-1 control
516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic cases, 560 Hispanic controls
88 European ancestry cases, 517 European ancestry controls
324 European ancestry medically refractory ulcerative colitis cases, 537 European ancestry non-medically refractory ulcerative colitis cases, 2,601 European ancestry controls
576 European ancestry individuals, 12 Black individuals, 2 individuals
444 European ancestry and Hispanic cases, 300 European ancestry and Hispanic controls
Congenital heart malformation
945 Han Chinese ancestry cases, 1,246 Han Chinese ancestry controls
2,160 Han Chinese ancestry cases, 3,866 Han Chinese ancestry controls
801 European ancestry long-living individuals, 914 European ancestry controls
292 European ancestry long-living individuals, 21 long-living individuals, 867 controls
Mean forced vital capacity from 2 exams
Up to 1,222 individuals
10,995 European ancestry individuals
4,848 European ancestry individuals
Orofacial clefts (maternal alcohol consumption interaction)
272 European ancestry trios, 259 Asian ancestry trios, 19 African ancestry or other ancestry trios
Soluble levels of adhesion molecules
Up to 9,813 European ancestry individuals
Body mass in chronic obstructive pulmonary disease
2,950 European ancestry cases
502 European ancestry cases
15,821 European ancestry individuals
Up to 17,801 European ancestry individuals
Affymetrix, Illumina [2260683] (imputed)
1,926 European ance other ancestry cases, 2,522 European and other ancestry controls
332 European ancestry cases, 462 European ancestry controls, 2,181 European and other ancestry cases, 4,290 European and other ancestry controls
2,237 Sub-Saharan African ancestry cases, 3,122 Sub-Saharan African ancestry controls
1,462 Sub-Saharan African ancestry cases, 4,604 Sub-Saharan African ancestry controls
531 Sub-Saharan African ancestry cases, 848 Sub-Saharan African ancestry controls
30,968 European ancestry individuals
8,541 European ancestry individuals
218 European ancestry cases, 519 European ancestry controls
1,153 European ancestry cases, 1,217 European ancestry controls
1,154 European ancestry cases, 1,137 European ancestry controls
2,724 European ancestry cases, 3,694 European ancestry controls
20,890 European ancestry individuals
16,178 European ancestry individuals
Affymetrix, Illumina [2534500] (imputed)
201 European ancestry cases, 305 European ancestry controls
2,663 European ancestry cases, 13,780 European ancestry controls
844 European ancestry cases, 1,255 European ancestry controls
1,547 European ancestry cases, 1,209 European ancestry controls
6,865 European ancestry individuals
8,510 European ancestry individuals
458 lithium-treated cases, 719 non-lithium treated cases
359 European ancestry lithium-treated cases
376 Japanese ancestry cases, 934 Japanese ancestry controls
376 Japanese ancestry cases, 1,097 Japanese ancestry controls
Adiposity
38,580 European ancestry individuals
Up to 102,064 European ancestry individuals
Affymetrix, Illumina [2573738] (imputed)
31,373 European ancestry individuals
38,641 individuals
Osteoporosis-related phenotypes
2,073 related female individuals
418 Japanese ancestry cases, 300 Japanese ancestry controls
409 Japanese ancestry cases, 448 Japanese ancestry controls
1,878 European ancestry cases, 3,670 European ancestry controls
2,545 European ancestry cases, 2,953 European ancestry controls
Cardiac hypertrophy
851 Old Order Amish individuals
1,840 European ancestry cases, 5,163 European ancestry controls and (Liu et al)
620 European ancestry cases, 2,514 European ancestry controls
1,539 European ancestry cases, 3,917 European ancestry controls
2,312 European ancestry cases, 1,867 European ancestry controls
Cutaneous nevi
1,524 European ancestry twins
4,107 European ancestry individuals, 3,131 European ancestry cases, 4,276 European ancestry controls
1,179 European ancestry cases, 1,108 European ancestry controls
1,165 European ancestry cases, 1,302 European ancestry controls
10,074 European ancestry individuals
Affymetrix, Illumina, Perlegen [2228850] (imputed)
3,192 European ancestry individuals
1,722 European ancestry individuals
408 Old Order Amish female individuals, 460 Old Order Amish male individuals
Framingham Heart Study (Sample size NR)
Fat intake
598 European ancestry adolescents
490 European ancestry young adult individuals
563 European ancestry cases, 1,146 European ancestry controls, 483 European ancestry trios
3,303 European ancestry cases, 4,673 European ancestry controls
3,941 European ancestry cases, 7,848 European ancestry controls
2,023 European ancestry cases, 2,340 European ancestry controls
446 cases, 290 controls
415 cases, 260 controls
26 European ancestry cases, 3 Hispanic cases, 1 African American case, 26 European ancestry controls, 3 Hispanic controls, 1 African American control
479 European ancestry cases, 2,937 European ancestry controls
4,143 European ancestry cases, 6,515 European ancestry controls, 1,782 East Asian ancestry cases, 1,865 East Asian ancestry controls, 741 cases, 1,517 controls
864 European ancestry cases, 864 European ancestry controls
1,230 European ancestry cases, 1,251 European ancestry controls
2,392 European ancestry cases, 2,271 European ancestry controls
499 European ancestry cases, 490 European ancestry controls
1,649 cases, 1,832 controls
94 Japanese ancestry cases, 94 Japanese ancestry controls
Idiopathic membranous nephropathy
556 European ancestry cases, 2,338 European ancestry controls
1,607 Japanese ancestry cases, 1,428 Japanese ancestry controls
3,439 Japanese ancestry cases, 3,244 Japanese ancestry controls
Phytosterol levels
1,495 European ancestry individuals
2,917 European ancestry individuals
2,094 European ancestry female individuals
6,463 European ancestry individuals
407 European ancestry cases, 296 European ancestry controls
252 European ancestry cases, 965 European ancestry controls
939 European ancestry cases, 975 European ancestry controls, 1,097 European ancestry individuals from 270 families
2,637 European ancestry cases, 3,957 European ancestry controls
5,106 European ancestry individuals
734 European ancestry individuals
464 European ancestry individuals
566 European ancestry individuals
720 European ancestry individuals
194 Japanese ancestry cases, 1,558 Japanese ancestry controls
5,324 East Asian ancestry cases, 7,037 East Asian ancestry controls, 4,085 European ancestry cases, 5,302 European ancestry controls
159 Japanese ancestry cases, 934 Japanese ancestry controls
83 Japanese ancestry cases, 535 Japanese ancestry controls
4,714 European ancestry female individuals
16,373 European ancestry female individuals
459 individuals
1,160 individuals
Response to hepatitis C treatment
707 European ancestry cases
115 European ancestry cases, 2,976 European ancestry controls
76 European ancestry cases
Hearing impairment
846 European ancestry cases, 846 European ancestry controls
63 European ancestry cases, 67 European ancestry controls
Response to citalopram treatment
Up to 659 European ancestry responders, up to 121 African American responders, up to 103 Hispanic responders, 408 European ancestry non-responders, 120 African American non-responders, 80 Hispanic non-responders
1,053 European ancestry individuals
588 European ancestry individuals
1,924 European ancestry cases, 2,938 European ancestry controls
3,757 European ancestry cases, 5,346 European ancestry controls
Obesity and osteoporosis
499 European ancestry male individuals, 501 European ancestry female individuals
1,370 European ancestry male individuals and 1,985 European ancestry female individuals from 975 families
1,082 European ancestry cases, 1,239 European ancestry controls
1,400 controls
482 European ancestry cases, 522 European ancestry controls
4,221 Sardinian individuals
1,828 Sardinian individuals, 813 Old Order Amish individuals
809 Old Order Amish individuals
698 Old Order Amish individuals
519 Japanese ancestry cases, 503 Japanese ancestry controls
5,110 Japanese ancestry cases, 6,867 Japanese ancestry controls
1,748 cases, 2,938 controls
1,182 European ancestry cases, 2,024 European ancestry controls
364 European ancestry cases, 590 European ancestry controls
1,043 European ancestry cases, 1,769 European ancestry controls
Glomerulosclerosis
56 African American cases, 61 European ancestry cases, 1,759 African American controls, 1,531 European ancestry controls
299 European ancestry cases
2,000 European ancestry cases, 3,000 European ancestry controls
2,997 European ancestry trios, 4,000 European ancestry cases, 5,000 European ancestry controls
187 Japanese ancestry cases, 1,504 Japanese ancestry controls
6,552 East Asian ancestry cases, 6,621 East Asian ancestry controls, 2,830 European ancestry cases, 3,740 European ancestry controls
133 Korean ancestry cases, 557 Korean ancestry controls
1,107 European ancestry cases, 2,747 European ancestry controls
2,287 European ancestry female individuals
870 European ancestry female individuals
Vitiligo (non-segmental)
20 Korean ancestry cases, 192 Korean ancestry controls
184 Korean ancestry cases, 192 Korean ancestry controls
HIV-1 viral setpoint
486 European ancestry cases
140 European ancestry cases
1,043 European ancestry cases, 1,703 European ancestry controls
2,539 European ancestry cases, 5,428 European ancestry controls
1,889 European ancestry cases, 39,310 European ancestry controls
2,850 European ancestry cases, 6,239 European ancestry controls
401 European ancestry cases, 1,644 European ancestry controls
906 European ancestry cases, 891 European ancestry controls, 255 French Canadian cases, 287 French Canadian controls
280 European ancestry cases, 360 European ancestry controls
1,833 European ancestry cases, 1,035 European ancestry controls, 167 Hispanic cases, 167 Hispanic controls
467 European ancestry trios, 561 European ancestry cases, 1,143 European ancestry controls
390 European ancestry trios, 1,333 European ancestry cases from 549 families
Prion diseases
1,281 European ancestry cases, 6,015 European ancestry controls, 290 Papua New Guinean ancestry cases, 286 Papua New Guinean ancestry controls
19,608 East Asian ancestry individuals
30,765 East Asian ancestry individuals
Affymetrix, Illumina [1700000] (imputed)
C4b binding protein levels
352 European ancestry related individuals
424 European ancestry cases, 226 European ancestry controls
521 cases and 19,090 controls of Black and European ancestry
Up to 67,093 European ancestry individuals
Up to 22,982 European ancestry individuals
4,857 European ancestry cases, 8,987 European ancestry controls
1,950 Chinese ancestry cases
4,160 Chinese ancestry cases
Radiation response
93 African American human lymphoblastoid cell lines, 89 European ancestry human lymphoblastoid cell lines, 95 Han Chinese ancestry human lymphoblastoid cell lines
Diabetic retinopathy
103 Mexican American cases, 183 Mexican American controls
2,010 Chinese ancestry cases, 1,945 Chinese ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 977 Asian Indian ancestry cases, 1,169 Asian Indian ancestry controls
63,678 European ancestry individuals 1,792 Erasmus Rucphen individuals, 715 Orcadian individuals
16,540 European ancestry individuals
Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN)
up to 72 European ancestry cases, up to 4,251 European ancestry controls
305 Japanese ancestry cases, 355 Japanese ancestry controls
969 European ancestry cases, 957 European ancestry controls
5,698 European ancestry cases, 38,633 European ancestry controls
13,685 European ancestry individuals
15,854 European ancestry individuals
Affymetrix, Illumina [up to 2543686] (imputed)
4,925 European ancestry individuals, 350 Chinese ancestry hip fracture cases, 350 Chinese ancestry hip fracture controls, 2,955 Chinese ancestry individuals, 908 West African ancestry males
5,429 Chinese ancestry individuals, 2,431 Malay ancestry individuals, 2,531 Asian Indian ancestry individuals
1,606 European ancestry individuals
8,617 European ancestry individuals
1,164 European ancestry ischemic cases, 380 European ancestry cases, 18,058 European ancestry controls
259 African American ancestry ischemic cases, 41 African American ancestry cases, 2,704 African American ancestry controls, 652 European ancestry ischemic cases, 3,613 European ancestry controls
Affymetrix, Illumina [2194468] (imputed)
871 European ancestry cases, 191 African American cases, 75 Hispanic cases
Lp (a) levels
357 Hutterite individuals
1,054 European ancestry males
900 Japanese ancestry individuals
1,810 Japanese ancestry individuals
823 cases, 810 controls
1,891 European ancestry individuals from 606 families, 389 European ancestry cases, 472 European ancestry controls, 949 individuals from 127 families
607 European ancestry cases, 3,294 European ancestry controls
Response to metformin in type 2 diabetes (glycemic)
1,024 European ancestry cases
2,896 European ancestry cases
Anti-cyclic Citrullinated Peptide Antibody
531 European ancestry cases
Amyotrophic lateral sclerosis (SNP x SNP interaction)
276 European ancestry cases, 271 European ancestry controls
3,683 European ancestry cases, 14,507 European ancestry controls
Affymetrix, Illumina [2366197] (imputed)
1,952 European ancestry cases, 1,438 European ancestry controls
2,465 European ancestry cases, 3,005 European ancestry controls, 3,143 individuals, 3,762 individuals
419 European ancestry cases, 1,228 European ancestry controls
1,757 European ancestry cases, 1,480 European ancestry controls
Up to 2,631 European ancestry individuals
up to 1,287 European ancestry individuals, 1,084 individuals
Up to 4,595 European ancestry individuals
1,045 individuals
Acute graft versus host disease
1,298 Allogenic hematopoietic cell transplantation donors and recipients
21,848 European ancestry individuals, 714 Orcadian individuals
17,083 European ancestry individuals, 714 Orcadian individuals
17,100 European ancestry individuals, 715 Orcadian individuals
20,697 European ancestry individuals, 715 Orcadian individuals
34,433 European ancestry individuals
Up to 100,347 European ancestry individuals, up to 12,889 Indian Asian ancestry individuals
Affymetrix, Illumina [2497993] (imputed)
Blue vs. green eyes
5,130 Icelandic individuals
3,330 European ancestry individuals
Burning and freckling
Skin sensitivity to sun
Blond vs. brown hair color
5,130 European ancestry individuals
Red vs. non-red hair color
400 European ancestry cases, 400 European ancestry controls
410 European ancestry cases, 394 European ancestry controls
Hoarding
3,304 European ancestry individuals
38,238 European ancestry individuals
62,264 European ancestry individuals
76,558 European ancestry individuals
37,037 European ancestry individuals
Homeostasis model assessment of beta-cell function
36,466 European ancestry individuals
11,185 European ancestry cases, 10,768 European ancestry controls
1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals
19,633 Japanese ancestry individuals
1,092 European ancestry individuals
721 Japanese ancestry cases, 2,890 Japanese ancestry controls
673 Japanese ancestry cases, 2,596 Japanese ancestry controls
1,341 European ancestry cases, 3,496 European ancestry controls
9,779 European ancestry cases, up to 31,818 European ancestry controls, 3,818 cases, 7,278 controls
249 Ashkenazi Jewish non-BRCA1/2 carriers cases, 299 Ashkenazi Jewish non-BRCA1/2 carriers controls
1,193 Ashkenazi Jewish non-BRCA1/2 carriers cases,1,166 Ashkenazi Jewish non-BRCA1/2 carriers controls
1,004 Japanese ancestry cases, 1,900 Japanese ancestry controls
1,094 East Asian ancestry cases, 9,148 East Asian ancestry controls
1,231 Chinese ancestry cases, 785 Chinese ancestry controls, 1,018 Malay ancestry cases, 1,220 Malay ancestry controls
825 Indian ancestry cases, 1,314 Indian ancestry controls, 760 Chinese ancestry child cases, 169 Chinese ancestry child controls, 397 Chinese ancestry trios
2,810 European ancestry children
4,804 European ancestry children
359 European ancestry cases, 846 European ancestry controls
2,981 European ancestry cases, 12,358 European ancestry controls, 769 European ancestry and hispanic cases, 1,007 European ancestry and hispanic controls, 592 Hispanic cases with their 1,184 Hispanic parental controls, 2,258 African American cases, 3,006 African American controls
Immunoglobulin A
430 European ancestry cases, 1,090 European ancestry controls
342 European ancestry cases, 886 European ancestry controls
Lipoprotein-associated phospholipase A2 activity change in response to statin therapy
2,673 European ancestry cases, 2,656 European ancestry controls
Lipoprotein-associated phospholipase A2 activity and mass
6,851 European ancestry individuals
13,664 European ancestry individuals
17,510 European ancestry female individuals
Ribavirin-induced anemia
453 Japanese ancestry individuals
470 Japanese ancestry individuals
4,763 Northern Finnish founder individuals
Metabolic traits
664 European ancestry cases, 422 European ancestry controls
664 cases, 422 controls
363 South Asian ancestry low maxL* individuals, 374 South Asian ancestry high maxL* individuals
116 South Asian ancestry low maxL* individuals, 115 South Asian ancestry high maxL* individuals
Hepatitis C induced liver cirrhosis
682 Japanese ancestry cases, 1,045 Japanese ancestry controls
936 Japanese ancestry cases, 3,809 Japanese ancestry controls
946 cases, 977 controls
530 trios, 353 cases, 207 controls
Waist circumference and related phenotypes
2,684 Indian Asian ancestry male individuals
7,394 Indian Asian ancestry individuals, 4,561 European ancestry individuals
1,172 European ancestry cases, 1,157 European ancestry controls
3,124 European ancestry cases, 3,142 European ancestry controls
134 European ancestry cases, 320 European ancestry controls
1,073 European ancestry individuals
524 individuals
5,739 European ancestry cases, 5,848 European ancestry controls
7,561 European ancestry cases, 13,818 European ancestry controls
16,876 European ancestry adult individuals
60,352 European ancestry adult individuals, 5,988 European ancestry children
2,979 European ancestry female individuals
2,560 European ancestry female individuals
429 Amish individuals
140 European ancestry individuals, 83 African American individuals, 4 individuals
542 Old Order Amish individuals
5,229 European ancestry individuals, 1,347 Amish individuals, 575 Hutterite individuals
AIDS
85 European ancestry cases, 2,049 European ancestry controls
178 European ancestry cases, 144 European ancestry controls
105 Pima Indian ancestry cases, 102 Pima Indian ancestry controls
288 European ancestry cases, 344 European ancestry controls
213 European ancestry cases, 391 European ancestry controls
220 European ancestry cases, 260 European ancestry controls
331 European ancestry cases, 368 European ancestry controls
509 African American cases, 508 African American controls
366 West African ancestry cases, 614 West African ancestry controls
1,001 European ancestry cases, 2,401 European ancestry controls
796 European ancestry cases, 876 European ancestry controls
Menarche and menopause (age at onset)
17,438 European ancestry female individuals
229 Hispanic individuals from 34 families
961 Hispanic individuals from 59 families
58 European ancestry cases, 282 European ancestry controls
775 European ancestry cases, 3,197 European ancestry controls
152 cases, 170 controls
654 European ancestry individuals
9,353 European ancestry individuals
1,392 European ancestry depression cases, 264 African American depression cases, 106 depression cases
2,624 European ancestry cases, 7,220 European ancestry controls
2,215 European ancestry cases, 2,116 European ancestry controls
Affymetrix, Illumina [~ 2560000] (imputed)
19,195 European ancestry individuals
Affymetrix, Illumina [2543686] (imputed)
1,507 European ancestry cases, 34,033 European ancestry controls
2,266 European ancestry cases, 8,477 European ancestry controls
17,686 European ancestry female individuals
907 European ancestry cases, 2,398 European ancestry controls
635 Han Chinese ancestry cases, 1,640 Han Chinese ancestry controls
505 European ancestry cases, 1,507 European ancestry controls
526 European ancestry cases, 1,206 European ancestry controls
Hippocampal atrophy
162 European ancestry cases, 192 European ancestry controls, 7 African American cases, 14 African American controls, 1 Asian ancestry cases, 3 Asian ancestry controls, 2 cases
374 European ancestry individuals
10,365 cases, 16,110 controls
4,659 European ancestry individuals
13,795 European ancestry individuals
Affymetrix, Illumina [2585854] (imputed)
Methamphetamine dependence
240 East Asian ancestry cases, 340 East Asian ancestry controls
111 European ancestry cases, 5,951 European ancestry controls
85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals
88,823 European ancestry individuals
Affymetrix, Illumina [2516789] (imputed)
793 European ancestry cases, 1,988 European ancestry controls
917 European ancestry cases, 1,546 European ancestry controls, 1,667 African American cases, 2,045 African American controls
Major depressive disorder (broad)
3,957 European ancestry cases, 3,428 European ancestry controls
Affymetrix, Perlegen [2391203] (imputed)
547 European ancestry cases, 549 European ancestry controls
Monocyte early outgrowth colony forming units
1,654 European ancestry individuals
2,362 European ancestry cases
2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls
5,327 European ancestry cases, 16,424 European ancestry controls
Up to 4,274 European ancestry individuals
Up to 15,873 European ancestry individuals
778 Old Order Amish individuals
387 European ancestry individuals from 21 families
1,238 individuals
Up to 77,167 European ancestry individuals
Up to 113,636 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 2850269] (imputed)
735 trios from 732 families
Neuroticism (age interaction)
2,235 European ancestry individuals
462 Hutterite individuals
583 Costa Rican ancestry trios, 1,181 European ancestry cases, 7,369 European ancestry controls
Up to 3,991 European ancestry individuals
Up to 840 African American individuals
Affymetrix, Illumina [~ 2330000] (imputed)
Non-small cell lung cancer
621 Korean ancestry cases, 1,541 Korean ancestry controls
804 Korean ancestry cases, 1,470 Korean ancestry controls
584 East Asian ancestry cases, 585 East Asian ancestry controls
2,184 East Asian ancestry cases, 2,515 East Asian ancestry controls
140 European ancestry cases, 117 European ancestry controls, 57 African American cases, 72 African American controls, 2 cases, 9 controls
2,554 Indian Asian ancestry individuals
2,240 Indian Asian ancestry individuals
Speech perception in dyslexia
186 European ancestry cases
9,492 European ancestry individuals
929 Sorbian (founder/genetic isolate) individuals
5,758 European ancestry individuals
Response to platinum-based chemotherapy in head and neck cancers
90 East Asian ancestry lymphoblastoid cell lines
90 European ancestry lymphoblastoid cell lines, 59 Yoruban ancestry lymphoblastoid cell lines
90 European ancestry Lymphoblastoid cell lines
500 European ancestry male individuals, 477 European ancestry female individuals
5,333 European ancestry cases, 12,019 European ancestry controls
7,053 cases, 9,007 controls
Frontotemporal lobar degeneration
515 European ancestry cases, 2,509 European ancestry controls
89 European ancestry cases, 553 European ancestry controls
13,665 European ancestry individuals
16,482 European ancestry individuals
1,553 cases from 1,031 families
2,073 trios
Major mood disorders
6,686 European ancestry cases, 9,068 European ancestry controls
1,930 European ancestry cases, 2,747 European ancestry controls
up to 46,368 European ancestry individuals
894 European ancestry cases, 1,516 European ancestry controls
3,772 European ancestry cases, 8,505 European ancestry controls
Up to 12,670 European ancestry individuals
Up to 10,352 European ancestry individuals
174 Han Chinese ancestry Type 2 diabetes cases, 575 Han Chinese ancestry Type 2 diabetes controls, 100 Han Chinese ancestry non-diabetic controls
1,782 European ancestry individuals
Emphysema-related traits
2,383 European ancestry cases
847 European ancestry cases, 552 European ancestry controls, 345 African American cases, 140 African American controls
262 families
160 European ancestry cases, 80 European ancestry controls
859 European ancestry cases, 554 European ancestry controls
Nephrotic syndrome (acquired)
195 Japanese ancestry cases, 1,546 Japanese ancestry controls
662 Japanese ancestry cases, 4,919 Japanese ancestry controls
518 Vietnamese-Korean ancestry individuals from 165 families
1,808 European ancestry cases, 915 European ancestry controls
10,585 European ancestry cases, 6,468 European ancestry controls
Affymetrix, Illumina [> 2400000] (imputed)
Myocardial infarction in coronary artery disease
4,572 European ancestry cases, 2,739 European ancestry controls
1,211 European ancestry cases, 905 European ancestry controls
1,461 European ancestry cases, 2,008 European ancestry controls
409 European ancestry trios from 256 families, 365 European ancestry cases, 351 European ancestry controls
Creutzfeldt-Jakob disease
117 European ancestry cases, 3,083 European ancestry controls
2 European ancestry vCJD cases, 506 Oceania ancestry sCJD cases, 28 Oceania ancestry iCJD cases, 151 Oceania ancestry Kuru cases, 125 Oceania ancestry Kuru resistant cases, 3,608 European ancestry controls, 562 Oceania ancestry controls
100 European ancestry > 445ms female individuals, 100 European ancestry < 386ms female individuals
200 European ancestry > 85th pct female individuals, 200 European ancestry < 15th pct female individuals, 4,451 European ancestry individuals
860 European ancestry children
2,619 European ancestry children
3,012 European ancestry individuals
991 Japanese ancestry cases, 5,209 Japanese ancestry controls
Asthma (toluene diisocyanate-induced)
84 Korean ancestry cases, 263 Korean ancestry controls
Alzheimer's disease biomarkers
96 European ancestry Alzheimer disease cases, 176 European ancestry individuals with mild cognitive impairment, 102 European ancestry controls
1904 African American individuals
411 African American individuals
Brain cytoarchitecture
14 European ancestry bipolar cases, 15 European ancestry depression cases, 13 European ancestry schizophrenia cases, 14 European ancestry controls
Nevus count
1,810 European ancestry twins
1,470 European ancestry parents of twins, 2,247 European ancestry twins, 485 European ancestry individuals, 925 European ancestry melanoma cases
1,222 European ancestry cases, 1,298 European ancestry controls
18,185 European ancestry cases, 20,068 European ancestry controls
20,611 European ancestry individuals
5,328 European ancestry individuals
10,280 European ancestry individuals
997 European ancestry cases, 989 European ancestry controls
Response to treatment for acute lymphoblastic leukemia
356 European ancestry cases, 53 Black cases, 78 cases
201 Finland founder cases, 200 Finland founder controls, 200 Ashkenazi Jewish cases, 197 Ashkenazi Jewish controls, 99 European ancestry cases, 100 European ancestry controls
2,573 European ancestry cases, 2,776 European ancestry controls
Multiple sclerosis (severity)
1,040 European ancestry cases
6,247 African American individuals
2,022 African American individuals
Otosclerosis
302 cases, 302 controls
847 cases, 872 controls
5,568 European ancestry cases, 7,187 European ancestry controls, 1,000 Taiwanese ancestry cases, 1,000 Taiwanese ancestry controls
1,115 European ancestry cases, 2,728 European ancestry controls
1,359 European ancestry cases, 1,782 European ancestry controls
192 European ancestry cases, 37,196 European ancestry controls
432 European ancestry cases, 1,727 European ancestry controls
1,496 Chinese ancestry individuals
3,851 European, Chinese and other ancestry cases, 3,934 European, Chinese and other ancestry controls
1,771 European ancestry cases, 1,805 European ancestry controls
2,120 European ancestry cases, 2,127 European ancestry controls
1,618 European ancestry cases, 3,413 European ancestry controls
2,256 European ancestry cases, 2,310 European ancestry controls
3,413 cases, 37,105 referents
2,145 cases, 4,073 controls
17,967 European ancestry and Indian Asian ancestry individuals
13,615 European ancestry and Indian Asian ancestry Individuals
Affymetrix, Illumina, Perlegen [~ 1400000] (imputed)
Two-hour glucose challenge
15,234 individuals
up to 30,620 European ancestry individuals
476 European ancestry cases, 1,358 European ancestry controls
1,024 European ancestry cases, 996 European ancestry controls
277 European ancestry cases, 919 European ancestry controls
371 European ancestry cases with their 408 parents, 860 European ancestry controls
182 South Asian ancestry individuals
7,514 European ancestry cases, 9,045 European ancestry controls
4,267 European ancestry cases, 4,670 European ancestry controls, 4,342 European ancestry trios from 2,319 families
Lumiracoxib-related liver injury
31 European ancestry cases, 3 Hispanic cases, 1 case, 176 European, Hispanic and other ancestry controls
79 European ancestry cases, 16 Hispanic ancestry cases, 1 case, 405 European, Hispanic and other ancestry controls
Up to 6,616 individuals
Angiotensin-converting enzyme activity
400 Han Chinese ancestry hypertensive cases
623 Han Chinese ancestry hypertensive cases
32 Romanian founder cases, 44 European ancestry controls
1,768 European ancestry cases, 2,354 European ancestry controls
8,709 European ancestry cases, 51,764 European ancestry controls
Inflammatory bowel disease (early onset)
2,413 European ancestry cases, 6,158 European ancestry controls
1,013 European ancestry cases, 5,805 European ancestry controls
931 cases, 1,104 controls
1,338 cases, 2,003 controls
617 European ancestry cases, 4,583 European ancestry controls
1,011 cases, 7,604 controls
785 Han Chinese ancestry extreme high and low BMD female individuals
264 Han Chinese ancestry High BMD individuals, 456 Han Chinese ancestry Low BMD individuals, 3,465 Han Chinese ancestry individuals, 13,913 European ancestry individuals
Polyunsaturated fatty acid levels
1,076 European ancestry individuals
2,361 European ancestry cases, 5,417 European ancestry controls
2,321 European ancestry cases, 4,818 European ancestry controls
1,191 European ancestry cases, 999 European ancestry controls
872 European ancestry cases, 810 European ancestry controls
134 Japanese ancestry cases, 137 Japanese ancestry controls
3,954 East Asian ancestry cases, 13,222 East Asian ancestry controls
72 Japanese ancestry cases, 45 Japanese ancestry controls
63 Japanese ancestry cases, 45 Japanese ancestry controls
5,840 European ancestry individuals, 771 Sorbian (founder/genetic isolate) individuals
4,050 European ancestry individuals
135 European ancestry asthma child cases, 134 European ancestry rhinoconjunctivitis child cases
35 asthma child cases, 44 rhinoconjunctivitis child cases
882 European ancestry cases, 473 European ancestry controls
1,436 European ancestry cases, 1,780 European ancestry controls
1,113 European, African, Oceania, Hispanic and other ancestry individuals from 418 families
562 European ancestry cases, 666 European ancestry controls, 137 cases, 2,126 controls
807 Japanese ancestry low dose individuals, 701 Japanese ancestry high dose individuals
444 Japanese ancestry individuals
322 Plains American Indian ancestry individuals
185 European ancestry individuals
2,591 European ancestry cases, 3,052 European ancestry controls
10,870 European ancestry cases, 73,735 European ancestry controls
421 European ancestry, 214 African American, and 103 cases
186 Korean ancestry child cases, 600 Korean ancestry controls
514 East Asian ancestry child cases, 1,042 East Asian ancestry controls
Coagulation factor levels
3,250 European ancestry individuals, up to 212 individuals
up to 2,322 European ancestry individuals from 118 families
2,647 European ancestry individuals
Male infertility
52 European ancestry oligozoospermic cases, 40 European ancestry non-obstructive azoospermic cases, 80 European ancestry controls
224 European ancestry cases, 383 European ancestry controls
246 cases, 954 controls
HIV-1 replication
191 European ancestry individuals
31 individuals
Body mass index and fat mass
948 Sorbian (founder/genetic isolate) individuals
973 European ancestry individuals
1,488 European ancestry individuals, 1,972 European ancestry individuals from 593 families, 2,955 Chinese ancestry individuals
Type 1 diabetes autoantibodies
Up to 2,142 European ancestry cases
855 European ancestry affected family members
856 European ancestry cases, 2,836 European ancestry controls
1,298 European ancestry cases, 7,136 European ancestry controls
2,617 European ancestry smokers, 1,725 European ancestry controls
2,349 European ancestry individuals, 664 Chinese ancestry individuals, 1,366 African American individuals, 1,171 Hispanic individuals
Helicobacter pylori serologic status
2,623 European ancestry high titer cases, 7,862 European ancestry low or no titer controls
4,387 European and unknown ancestry bipolar disorder cases, 1,695 major depressive disorder cases, 7,970 European and unknown ancestry controls
Affymetrix, Perlegen [1472580] (imputed)
4,387 European and unknown ancestry cases, 6,209 European and unknown ancestry controls
1,695 cases, 1,761 controls
Up to 427 European ancestry cases, up to 4,352 European ancestry controls
661 European ancestry cases, 1,299 European ancestry controls
Malignant pleural mesothelioma
392 European ancestry cases, 367 European ancestry controls
428 European ancestry cases, 1,269 European ancestry controls
1,394 Japanese ancestry cases, 6,599 Japanese ancestry controls
1,802 Japanese ancestry cases, 7,212 Japanese ancestry controls
Circulating cell-free DNA
1,841 individuals
74,354 European ancestry individuals
56,246 European ancestry individuals
2,267 European ancestry individuals, 99 Hispanic individuals, 999 African American individuals
835 individuals
Bitter taste response
1,457 European ancestry individuals
73 European ancestry individuals
3,497 European ancestry individuals
6,215 individuals, 1,648 twins
520 Korean ancestry cases, 8,314 Korean ancestry controls
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN)
14 Japanese ancestry cases, 991 Japanese ancestry controls
315 European ancestry cases
434 European ancestry cases
1149 European ancestry Alzheimer disease cases, 336 European ancestry individuals with mild cognitive impairment, 188 European ancestry controls
419 African American Alzheimer disease cases
18,176 European ancestry individuals
7,929 European ancestry individuals
Affymetrix, Illumina, Perlegen [~ 2600000] (imputed)
893 European ancestry cases, 2,199 European ancestry controls
1,411 European ancestry cases, 1,431 European ancestry controls
778 European ancestry cases, 4,414 European ancestry controls, 242 Ashkenazi Jewish cases, 354 Ashkenazi Jewish controls, 265 French Canadian founder cases, 196 French Canadian founder controls
211 Latin American cases, 285 Latin American controls
Brachial circumference
18,753 European ancestry individuals
3,623 European ancestry individuals
Affymetrix, Illumina [2238430] (imputed)
Chronic fatigue syndrome
40 European ancestry cases, 40 European ancestry controls
Permanent tooth development
5,088 European ancestry females
2,994 European ancestry individuals, 161 individuals
2,702 European ancestry individuals
2,550 European ancestry individuals
2,111 European ancestry cases, 2,535 European ancestry controls
11,271 European ancestry cases, 14,601 European ancestry controls
Bipolar disorder and schizophrenia
2,111 European ancestry schizophrenia cases, 836 European ancestry bipolar disorder cases, 2,535 European ancestry controls
836 European ancestry cases, 2,093 European ancestry controls
1,325 African ancestry, 828 African ancestry controls
2,229 African ancestry cases, 3,526 African ancestry controls
445 Korean ancestry cases, 497 Korean ancestry controls
396 Korean ancestry cases, 998 Korean ancestry controls
Cardiac structure and function
6,765 African American individuals
2,468 African American individuals, 12,612 European ancestry individuals
48,201 European ancestry individuals
46,411 European ancestry individuals
Lentiform nucleus volume
162 European ancestry Alzheimer's disease cases, 346 European ancestry mild cognitive impairment cases, 198 European ancestry controls, 639 European ancestry individuals from 364 families
436 European ancestry cases, 928 European ancestry controls
554 European ancestry cases, 609 European ancestry controls
7,373 East Asian ancestry individuals
Renal function-related traits (BUN)
39,717 East Asian ancestry individuals
17,461 East Asian ancestry individuals
Affymetrix, Illumina [2281523] (imputed)
Renal function-related traits (sCR)
42,257 East Asian, South Asian, and South East Asian ancestry individuals
19,662 East Asian ancestry individuals
Affymetrix, Illumina [2353587] (imputed)
Renal function-related traits (eGRFcrea)
42,451 East Asian, South Asian, and South East Asian ancestry individuals
19,636 East Asian ancestry individuals
Renal function-related traits (urea)
21,417 East Asian ancestry individuals
11,657 East Asian ancestry individuals
Affymetrix, Illumina [2278301] (imputed)
Pit-and-Fissure caries
Smooth-surface caries
982 European ancestry individuals
38,991 European ancestry individuals
2,789 Chinese ancestry individuals, 2,155 Malay ancestry individuals
Cataracts in type 2 diabetes
109 Han Chinese ancestry cases, 649 Han Chinese ancestry controls
6,597 European ancestry and Erasmus Rucphen individuals, 683 Sardinian inidividuals
19,763 European ancestry individuals
Affymetrix, Illumina [2093862] (imputed)
430 European ancestry HIV exposed uninfected Haemophilia cases, 765 European ancestry HIV positive controls
1,999 Chinese ancestry males
1,496 Chinese ancestry males
1,644 Latino individuals
124 Latino individuals
End-stage coagulation
2,100 European ancestry individuals
Schizophrenia (negative symptoms)
1,774 European ancestry cases, 2,726 European ancestry controls
up to 5,878 European ancestry individuals
up to 1,052 European ancestry individuals
Circulating vasoactive peptide levels
3,444 European ancestry individuals
3,230 European ancestry individuals
Aging (facial)
502 European ancestry females
372 Japanese ancestry cases,3,389 Japanese ancestry controls
Up to 1,151 Japanese ancestry cases, up to 15,800 Japanese ancestry controls
1,514 European ancestry cases, 12,660 European ancestry controls
505 European ancestry cases, 1,811 European ancestry controls
482 European ancestry cases, 466 European ancestry controls
568 European ancestry cases, 413 European ancestry controls
183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls
Factor XI
339 European ancestry individuals from 21 families
Up to 2,256 European ancestry cases
Affymetrix, Illumina [1200000] (imputed)
8,330 European ancestry individuals
Lipid metabolism phenotypes
922 European ancestry cases, 927 European ancestry controls
17,089 European ancestry cases, 16,862 European ancestry controls, 783 cases, 664 controls
221 Genetically Homogenous Irish cases, 211 Genetically Homogenous Irish controls
737 European ancestry cases, 721 European ancestry controls
1,011 European ancestry cases, 4,250 European ancestry controls
1,922 European ancestry cases, 14,124 European ancestry controls
194 Japanese ancestry cases, 1,539 Japanese ancestry controls
5,177 Japanese ancestry cases, 6,220 Japanese ancestry controls
Response to diuretic therapy
97 African American good response individuals, 97 African American poor response individuals, 98 European ancestry good response individuals, 97 European ancestry poor response individuals
338 European ancestry lung adenocarcinoma cases, 335 European ancestry controls
265 European ancestry non-small cell lung carcinoma cases, 356 European ancestry controls
505 European ancestry cases, 1,438 European ancestry controls
1,024 European ancestry cases, 1,677 European ancestry controls
317 European ancestry cases, 17,958 European ancestry controls
520 European ancestry cases, 540 European ancestry controls
1,196 European ancestry individuals
1,530 European ancesrty individuals
9,769 European ancestry individuals
946 European ancestry cases and 1,098 European ancestry controls from 549 families, 364 European ancestry trios
1,000 European ancestry cases, 1,034 European ancestry controls
Blood trace element (Se levels)
5477 European ancestry individuals
Blood trace element (Cu levels)
2,603 European ancestry individuals
Blood trace element (Zn levels)
1,658 European ancestry female individuals
1,059 European ancestry female individuals
4,627 European ancestry individuals
9,316 European ancestry individuals
Affymetrix, Illumina [~ 2110000] (imputed)
Hematological parameters
5,545 European ancestry cases, 12,153 European ancestry controls
12,328 European ancestry males, 15,813 European ancestry females
Affymetrix, Illumina [2493963] (imputed)
Brain development
557 French Canadian female adolescent individuals
2,601 European ancestry adolescent individuals
1,464 European ancestry cases, 1,467 European ancestry controls
5,065 European ancestry cases, 5,785 European ancestry controls, at least 18,129 cases and controls.
2,659 European ancestry type 2 diabetes cases and controls
5,217 European ancestry individuals
2,623 European ancestry type 2 diabetes cases and controls
2,601 European ancestry type 2 diabetes cases and controls
1,451 European ancestry type 2 diabetes cases and controls
1,161 European ancestry cases, 1,174 European ancestry controls
1,215 European ancestry cases, 1,258 European ancestry controls
513 African American cases, 496 African American controls
279 European ancestry cases, 184 European ancestry controls
up to 654 European ancestry cases, 2,024 European ancestry controls
Early cardiac repolarization
7,482 European ancestry individuals
7,151 European ancestry individuals
Affymetrix, Illumina [2523555] (imputed)
679 European ancestry cases, 697 European ancestry controls
5,579 European ancestry cases, 7,096 European ancestry controls
921 European ancestry cases, 929 European ancestry controls
1,214 European ancestry cases, 1,435 European ancestry controls
Ovarian reserve
232 European ancestry female individuals, 200 African American female individuals
618 Chinese ancestry individuals
2,953 Chinese ancestry individuals
2,731 European ancestry cases, 10,747 European ancestry controls
3,202 European ancestry cases, 40,062 European ancestry controls
494 European ancestry cases, 244 African American and other ancestry cases
131 European ancestry responders, 162 European ancestry non-responders
261 European ancestry responders, 294 European ancestry non-responders
2,622 European ancestry individuals
Affymetrix, Perlegen [~ 1600000] (imputed)
2,538 European ancestry individuals, 3,477 individuals
1,543 individuals
Illumina, Perlegen [~ 2500000] (imputed)
Up to 1,295 individuals
1,263 European ancestry cases, 34,887 European ancestry controls
2,175 European ancestry cases, 2,064 European ancestry controls
1,583 Japanese ancestry cases, 3,386 Japanese ancestry controls
3,001 Japanese ancestry cases, 5,415 Japanese ancestry controls
1,709 Filipino ancestry female individuals
Schizophrenia, bipolar disorder and depression (combined)
402 European ancestry schizophrenia cases, 1,021 European ancestry bipolar I cases, 493 European ancestry bipolar II cases, 1,210 European ancestry MDD cases, 1,060 European ancestry controls
Affymetrix, Perlegen [1574154] (imputed)
319 European ancestry cases, 769 European ancestry controls, 2,690 cases, 2,237 controls
4,982 European ancestry cases, 7,961 European ancestry controls, 2,190 cases, 3,374 controls
1,039 European ancestry cases, 1,984 European ancestry controls
3,232 European ancestry cases, 7,064 European ancestry controls
1,015 European ancestry chronic HCV carriers, 347 European ancestry spontaneously cleared HCV individuals
6,382 European ancestry females
970 European ancestry individuals
1,837 Han Chinese ancestry cases, 4,231 Han Chinese ancestry controls
2,100 Han Chinese ancestry cases, 3,496 Han Chinese ancestry controls
896 European ancestry cases, 3,204 European ancestry controls
1,174 European ancestry cases, 357 European ancestry controls
Testicular dysgenesis syndrome
488 European ancestry male cases, 439 European ancestry male controls
436 European ancestry male cases, 235 European ancestry male controls
436 European ancestry cases, 494 European ancestry controls
133 European ancestry cases and their parents, 266 European ancestry cases, 402 European ancestry controls
Thyroid function
2,014 European ancestry twins
1,093 European ancestry individuals
958 Gambian ancestry cases, 1,382 Gambian ancestry controls
1,087 Gambian ancestry cases, 2,376 Gambian ancestry controls
Up to 1,831 cases, up to 2,546 controls
Up to 4,064 cases, up to 4,685 controls
Illumina, Perlegen [up to 7456344] (imputed)
2,702 European ancestry female cases, 5,726 European ancestry controls
Up to 7,386 cases, 7,576 controls
Ileal carcinoids
239 European ancestry cases, 107 European ancestry controls
Response to TNF antagonist treatment
89 European ancestry cases
1,032 European ancestry cases, 2,043 European ancestry controls
720 European ancestry cases, 2,128 European ancestry controls
357 European ancestry cases, 285 European ancestry controls
1,177 European ancestry cases, 2,372 European ancestry controls
7,481 European ancestry individuals
~2000 European ancestry individuals
Adverse response to aromatase inhibitors
293 cases, 585 controls
Pubertal anthropometrics
up to 5,043 European ancestry males, up to 5,756 European ancestry females
7,161 European ancestry males, 6,879 European ancestry females
5,133 European ancestry males, 4,577 European ancestry females
IgE grass sensitization
2,315 European ancestry cases, 10,032 European ancestry controls
Affymetrix, Illumina [2217510] (imputed)
3,933 European ancestry cases, 8,965 European ancestry controls
222 Japanese ancestry cases, 389 Japanese ancestry controls
274 East Asian ancestry cases, 499 East Asian ancestry controls, 388 European ancestry cases, 397 European ancestry controls, 86 African American cases, 98 African American controls
Response to anti-TNF alpha therapy in inflammatory bowel disease
94 pediatric cases
961 Hispanic family members
up to 4,590 European ancestry individuals
431 European ancestry cases, 2,155 European ancestry controls
447 European ancestry trios, 293 trios
1,390 European ancestry individuals from 438 families
2,390 European ancestry individuals from 457 families
4,570 European ancestry female individuals
2,008 European ancestry female individuals
2,413 European ancestry cases, 2,392 European ancestry controls, 810 African American cases, 873 African American controls
3,393 European ancestry cases, 12,460 European ancestry controls
3,929 European ancestry cases, 5,807 European ancestry controls
Affymetrix, Illumina [at least 315971] (imputed)
2,971 European ancestry cases, 3,746 European ancestry controls
2,899 European ancestry cases, 5,573 European ancestry controls
175 Han Chinese ancestry cases, 175 Han Chinese ancestry controls
833 Han Chinese ancestry cases, 833 Han Chinese ancestry controls
1,523 European ancestry female individuals
435 European ancestry female individuals
Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction)
909 European ancestry trios
Conduct disorder (maternal expressed emotions interaction)
Attention deficit hyperactivity disorder and conduct disorder
938 European ancestry trios
958 European ancestry cases, 932 European ancestry controls
309 European ancestry cases, 404 European ancestry controls
3,972 Sardinian individuals
3,903 individuals
Stroke (ischemic)
1,661 European ancestry cases, 10,815 European ancestry controls
4,576 European ancestry cases, 19,343 European ancestry controls
8,918 European ancestry individuals, 3,947 Indian Asian ancestry individuals
4,126 European ancestry individuals
Affymetrix, Illumina, Perlegen [2557252] (imputed)
1,445 European ancestry individuals
5,882 European ancestry individuals
178 Japanese ancestry cases, 906 Japanese ancestry controls
621 Japanese ancestry cases, 2,271 Japanese ancestry controls
318 European ancestry cases, 288 European ancestry controls
2,361 European ancestry cases, 1,927 European ancestry controls
5,861 European ancestry individuals
7,925 European ancestry individuals
288 Korean ancestry cases, 1,139 Korean ancestry controls
831 East Asian ancestry cases, 2305 East Asian ancestry controls
Black vs. blond hair color
8,465 European ancestry individuals
Black vs. red hair color
Life threatening arrhythmia
607 European ancestry cases, 297 European ancestry controls
4,387 European ancestry cases, 6,209 European ancestry controls
281 Mexican American cases, 280 Mexican American controls
1,087 European ancestry individuals, 440 Pima Indian ancestry cases, 455 Pima Indian ancestry controls, 124 Amish cases, 295 Amish controls
833 Han Chinese ancestry cases, 3,094 Han Chinese ancestry controls
2,223 Han Chinese ancestry cases, 6,409 Han Chinese ancestry controls
281 Chinese ancestry cases, 481 Chinese ancestry controls
124 Chinese ancestry cases, 90 Chinese ancestry controls
303 Japanese ancestry cases
391 Japanese ancestry cases
Crohn's disease and sarcoidosis (combined)
382 European ancestry Crohn's disease cases, 398 European ancestry Sarcoidosis cases, 394 European ancestry controls
660 European ancestry Crohn's disease cases, 657 European ancestry Sarcoidosis cases, 1,091 European ancestry controls
160 Korean ancestry cases, 160 Korean ancestry controls
673 Korean ancestry cases, 267 Korean ancestry controls
2,385 European ancestry cases, 33,752 European ancestry controls
up to 2,427 European ancestry cases, 3,379 European ancestry controls, 286 Han Chinese ancestry cases, 2,763 Han Chinese ancestry controls
698 Asian Indian ancestry cases, 6,776 Asian Indian ancestry controls
4,462 European ancestry controls
53 responders, 53 non-responders
49 responders, 45 non-responders
2,178 European ancestry cases, 5,175 European ancestry controls
3,174 European ancestry cases, 5,464 European ancestry controls
2,032 European ancestry cases, 5,328 European ancestry controls
3,978 European ancestry cases, 3,297 European ancestry controls
175 European ancestry individuals
293 European ancestry individuals
Scoliosis
1,033 Japanese ancestry adolescent female cases, 1,473 Japanese ancestry female controls
326 Japanese ancestry adolescent female cases, 9,823 Japanese ancestry female controls
1,627 Han Chinese ancestry individuals
1,728 European ancestry female individuals
Cardiovascular disease risk factors
11,683 European ancestry individuals
5,132 European ancestry non-aggressive cases, 5,953 European ancestry aggressive cases, 11,463 European ancestry controls
22,387 European ancestry non-aggressive cases, 2,008 European ancestry aggressive cases, up to 24,726 European ancestry controls
223 cases, 248 stroke-affected siblings, 84 stroke-unaffected siblings
Pulmonary arterial hypertension (without BMPR2 mutations)
340 European ancestry cases, 1,068 European ancestry controls
285 cases, 457 controls
841 Amish individuals
663 Amish inidividuals
422 European ancestry trios with asthmatic children, 150 European ancestry asthmatic child cases
1,108 Hispanic asthmatic child cases
200 cases, 197 controls
1,161 European ancestry cases, 4,683 European ancestry controls
876 European ancestry cases, 1,890 European ancestry controls
Colorectal cancer (environment interaction)
314 European ancestry cases
259 European ancestry cases, 1,002 European ancestry controls
Relative hand skill in reading disability
728 European ancestry individuals with reading disability
Relative hand skill
2,666 European ancestry individuals
2,620 European ancestry males
1,101 Indo-European ancestry cases, 1,027 Indo-European ancestry controls
3,607 Indo-European ancestry cases, 2,924 Indo-European ancestry controls, 1,184 Dravidian ancestry cases, 1,061 Dravidian ancestry controls, 11,285 European ancestry cases, 11,285 European ancestry controls
39,400 European ancestry individuals
Up to 21,679 European ancestry individuals
Subclinical brain infarct
9,401 European ancestry individuals
1,822 European ancestry individuals, 644 Black individuals
Affymetrix, Illumina [2217889] (imputed)
β2-Glycoprotein I (β2-GPI) plasma levels
306 European ancestry individuals
Response to dabigatran etexilate treatment
1,490 European ancestry atrial fibrillation cases at risk of stroke
204 European ancestry atrial fibrillation cases at risk of stroke, 66 Latin American atrial fibrillation cases at risk of stroke, 1 Arab ancestry atrial fibrillation cases at risk of stroke, 5 Black African atrial fibrillation cases at risk of stroke, 25 East Asian ancestry atrial fibrillation cases at risk of stroke, 1 Colored African atrial fibrillation cases at risk of stroke, 9 South Asian ancestry atrial fibrillation cases at risk of stroke, 15 Asian ancestry atrial fibrillation cases at risk of stroke, 134 atrial fibrillation cases at risk of stroke
418 European ancestry cases
407 European ancestry cases
Narcolepsy with cataplexy
585 European ancestry cases
387 European ancestry cases
DNA methylation (parent-of-origin)
1,024 European ancestry individuals
DNA methylation (variation)
256 European ancestry individuals
384 European ancestry individuals
Response to Vitamin E supplementation
2,112 European ancestry individuals
1,442 Han Chinese ancestry cases, 1,468 Han Chinese ancestry controls
7,891 Han Chinese ancestry cases, 8,351 Han Chinese ancestry controls
6,358 Han Chinese ancestry cases, 6,722 Han Chinese ancestry controls
76 Norfolk Island (founder or genetic isolate) cases, 209 Norfolk Island (founder or genetic isolate) controls
4,705 European ancestry cases, 21,008 European ancestry controls
Immune response to anthrax vaccine
14,392 Japanese ancestry individuals
14,677 Japanese ancestry individuals
14,377 Japanese ancestry individuals
8,993 Japanese ancestry individuals
14,806 Japanese ancestry individuals
Up to 14,362 Japanese ancestry individuals
8,868 Japanese ancestry individuals
Up to 14,402 Japanese individuals
14,364 Japanese ancestry individuals
7,943 African American children, 6,234 European ancestry children
9,240 European ancestry individuals
2611 European ancestry individuals
2,583 European ancestry individuals
656 European ancestry individuals from ADHD families
2,045 European ancestry cases, 6,013 European ancestry controls
1,426 cases, 4,845 controls
Affymetrix, Illumina [2318094] (imputed)
Ulcerative colitis or Crohn's disease
372 Japanese ancestry Crohn's disease cases, 372 Japanese ancestry ulcerative colitis cases
607 Japanese ancestry Crohn's disease cases, 376 Japanese ancestry ulcerative colitis cases
472 European ancestry cases, 1,146 European ancestry controls
2,668, European ancestry cases, 762 French Canadian founder population cases, 2,585 cases, 3,485 European ancestry controls, 994 French Canadian founder population controls, 2,412 controls
4,637 East Asian ancestry individuals
4,205 East Asian ancestry individuals
1,591 European ancestry female individuals
626 European ancestry individuals from 235 families
651 European ancestry bipolar cases, 1,171 European ancestry schizophrenia cases, 2,412 European ancestry controls
Response to antipsychotic treatment in schizophrenia (working memory)
738 European ancestry, African American, and other ancestry cases
Response to antipsychotic treatment in schizophrenia (reasoning)
1,157 European ancestry cases, 1,748 European ancestry controls
7,887 European ancestry cases, 8,244 European ancestry controls
Gamma glutamyl transpeptidase
12,545 Korean ancestry individuals
Up to 30,395 East Asian ancestry individuals
Depression (quantitative trait)
3,972 Sardinian individuals, 839 European ancestry individuals
Up to 32,225 European ancestry individuals
11,509 European ancestry individuals, 11,163 individuals
1,006 Han Chinese ancestry cases, 2,273 Han Chinese ancestry controls
3,288 Han Chinese ancestry cases, 3,609 Han Chinese ancestry controls
Alopecia areata
729 European ancestry cases, 656 European ancestry controls
991 European ancestry cases, 2,021 European ancestry controls
16,179 European ancestry individuals
Electroencephalographic traits in alcoholism
1,560 European ancestry individuals from 117 families
112 European ancestry child cases, 165 European ancestry child controls
1,481 European ancestry individuals from 341 families, 429 European ancestry trios, 52 African American trios, 1,231 Hispanic trios, 46 trios, 6,475 European ancestry controls
1,180 European ancestry individuals from ~475 families
Airflow obstruction
up to 3,368 European ancestry cases, up to 29,507 European ancestry controls
331 European ancestry cases, 2,550 European ancestry controls
1,291 European ancestry cases, 938 European ancestry controls
509 European ancestry cases, 753 European ancestry controls, 2,218 cases, 2,583 controls
Renal sinus fat
2,809 European ancestry individuals
Asthma treatment response
1,169 European ancestry child and parent asthmatic cases
935 European ancestry adult asthmatic cases
1,772 individuals
393 European ancestry cases, 3,315 European ancestry controls
113 European ancestry cases, 214 European ancestry controls
Clozapine-induced agranulocytosis
161 European ancestry cases, 1,196 European ancestry clozapine-treated and untreated controls
2,168 European ancestry cases, 4,387 European ancestry controls
5,193 European ancestry cases, 15,144 European ancestry controls
252 Japanese ancestry cases, 249 Japanese ancestry controls
1,100 Japanese ancestry cases, 2,250 Japanese ancestry controls
37,956 African American individuals, 1,188 Nigerian ancestry individuals
27,661 African America/Afro-Caribbean individuals, 4,607 Sub-Saharan African ancestry individuals, 123,706 European ancestry inidividuals
Affymetrix, Illumina [3283202] (imputed)
2,123 Korean ancestry cases, 3,591 Korean ancestry controls
3,052 Japanese ancestry cases, 4,976 Japanese ancestry controls
Tumor biomarkers
10,326 Chinese ancestry individuals
Urinary symptoms in response to radiotherapy in prostate cancer
346 European, African, Hispanic and Asian ancestry individuals
377 European, African, Hispanic and Asian ancestry individuals
Pulmonary function in asthmatics
1,544 European ancestry individuals
718 Japanese ancestry cases, 1,717 Japanese ancestry controls
329 Japanese ancestry cases, 861 Japanese ancestry controls
93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Affymetrix, Illumina [~ 2800000] (imputed)
4,774 European ancestry high waist-to-hip ratio individuals, 5,481 European ancestry low waist-to-hip ratio individuals
3,351 European ancestry high waist-to-hip ratio individuals, 3,352 European ancestry low waist-to-hip ratio individuals
7,962 European ancestry high body mass index individuals, 8,106 European ancestry low body mass index individuals
4,900 European ancestry high body mass index individuals, 4,891 European ancestry low body mass index individuals
8,097 European ancestry tall individuals, 8,099 European ancestry short individuals
4,872 European ancestry tall individuals, 4,831 European ancestry short individuals
12,531 European ancestry individuals
8,216 Asian ancestry individuals
1,279 European ancestry cases, 5,139 European ancestry controls, 299 European ancestry trios, 93 South African Afrikaner ancestry cases, 158 South African Afrikaner ancestry controls, 93 Ashkenazi Jewish cases, 260 Ashkenazi Jewish controls, 101 Hispanic and unknown ancestry trios
44,147 European ancestry individuals
Affymetrix, Illumina [2090256] (imputed)
811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls
Suicide risk
3,117 European ancestry Bipolar disorder cases, 1,273 European ancestry Major depressive disorder cases
2,698 European ancestry Bipolar disorder cases, 1,649 Major depressive disorder cases
31,580 European ancestry individuals
31,277 European ancestry individuals
1,339 European ancestry cases
677 European ancestry cases
7,473 African American individuals
1,188 Sub-Saharan African individuals, 10,694 African American individuals, 69,899 European ancestry individuals
1,831 European ancestry cases, 1,764 European ancestry controls
751 cases, 751 controls
880 Amish individuals, 6,296 European ancestry individuals
592 European ancestry cases, 1,405 European ancestry controls
Intelligence (childhood)
12,441 European ancestry children
5,548 European ancestry children
Retinal vascular caliber
15,358 European ancestry individuals
6,652 European ancestry individuals
2,132 Indian ancestry individuals, 2,313 Malay ancestry individuals
9,326 European ancestry individuals
Type 2 diabetes and 6 quantitative traits
1,087 European ancestry individuals from 307 families
1,465 European ancestry individuals, 1,464 European ancestry cases, 1,467 European ancestry controls, 300 Pima Indian ancestry cases, 334 Pima Indian ancestry controls, 287 Mexican American cases, 316 Mexican American controls, 124 Old Order Amish cases, 295 Old Order Amish controls
440 American Indian ancestry cases, 455 American Indian ancestry controls
1,207 American Indian ancestry cases, 1,627 American Indian ancestry controls, 1,465 European ancestry individuals, 427 European ancestry controls, 760 Hispanic individuals
Non-small cell lung cancer (survival)
105 East Asian ancestry cases
95 Chinese ancestry HBV-infected cases, 97 Chinese ancestry HBV infected controls
500 Chinese ancestry HBV-infected cases, 728 Chinese ancestry HBV-infected controls
Response to ximelagatran treatment (increased serum alanine aminotransferase levels)
74 European ancestry cases, 130 European ancestry treated controls
10 European ancestry cases, 16 European ancestry treated controls
HIV-1 progression
51 European ancestry rapid progressor male cases, 57 European ancestry moderate progressor male cases, 48 European ancestry long-term progressor male cases
590 European ancestry seroconverter male cases
417 European ancestry male individuals, 423 European ancestry female individuals
412 African American male individuals and 839 African American female individuals from 402 families, 3,491 European ancestry male individuals and 4,132 European ancestry female individuals from 1,731 families
Factor VII
886 European ancestry individuals
Hemostatic factors and hematological phenotypes
Up to 1,062 European ancestry individuals
7,827 East Asian ancestry individuals
10,252 East Asian ancestry individuals
Fetal hemoglobin levels
4,305 European ancestry individuals
521 European ancestry individuals
Recombination rate (males)
1,887 male individuals
1,248 male individuals
Recombination rate (females)
1,702 female individuals
1,663 female individuals
up to 17,723 European ancestry individuals
up to 37,774 European ancestry individuals, up to 9,665 Indian Asian ancestry individuals
Affymetrix, Illumina, Perlegen [2155369] (imputed)
37 European ancestry cases, 36 European ancestry controls
249 European ancestry cases, 268 European ancestry controls
961 Hispanic individuals
461 European ancestry cases, 563 European ancestry controls
772 European ancestry cases, 876 European ancestry controls
322 European ancestry cases, 312 European ancestry controls
3,984 European ancestry cases, 19,807 European ancestry controls
1,955 European ancestry hypertensive individuals
2,033 European ancestry individuals from 519 families, 1,461 European ancestry twins
11,685 European ancestry individuals
Up to 4,979 European ancestry individuals
67 European ancestry cases, 1,952 European ancestry controls, 63 cases
930 European ancestry cases, 33,117 European ancestry controls
1,216 European ancestry cases, 2,844 European ancestry controls
753 European ancestry cases, 736 European ancestry controls
418 European ancestry cases, 249 European ancestry controls
4,305 Sardinian individuals
1,748 European ancestry cases, 2,938 European ancestry controls
(see Parkes 2007)
1,952 European ancestry cases, 2,938 European ancestry controls
(see Zeggini 2007)
1,860 European ancestry cases, 2,938 European ancestry controls
1,926 European ancestry cases, 2,938 European ancestry controls
(see Samani 2007)
1,868 European ancestry cases, 2,938 European ancestry controls
1,963 European ancestry cases, 2,938 European ancestry controls
(see Todd 2007)
Select biomarker traits
1,012 European ancestry individuals
166 Japanese ancestry schizophrenia cases, 323 Japanese ancestry controls
339 schizophrenia cases
Non-obstructive azoospermia
981 Han Chinese ancestry cases, 1,657 Han Chinese ancestry controls
1,946 Han Chinese ancestry cases, 4,077 Han Chinese ancestry controls
Osteonecrosis of the jaw
22 European ancestry cases, 65 European ancestry controls
F-cell distribution
179 European ancestry individuals
2,986 Icelandic ancestry individuals
3,932 European ancestry individuals
Blue vs. brown eyes
4,921 European ancestry individuals
19,064 European ancestry adult individuals, 6,827 European ancestry children
3,230 European ancestry cases, 4,829 European ancestry controls
1,339 European ancestry trios, 2,325 European ancestry cases, 1,809 European ancestry controls
Crohn's disease (time to surgery)
983 European ancestry cases
Crohn's disease (need for surgery)
239 European ancestry cases that required surgery within 5 year, 375 European ancestry cases that did not require surgery within 5 years
578 European ancestry cases, 547 European ancestry controls
1,351 European ancestry cases, 2,485 European ancestry controls
Brain structure (hippocampal volume)
162 European ancestry Alzheimer's disease cases, 343 European ancestry amnestic mild cognitive impairment cases, 193 European ancestry healthy elderly controls
Brain structure (temporal lobe volume)
173 European ancestry Alzheimer's disease cases, 361 European ancestry Mild Cognitive Impairment cases, 208 European ancestry controls
1,029 European ancestry individuals
99 European ancestry cases, 235 European ancestry controls
60 European ancestry cases, 90 European ancestry controls
5,951 European ancestry individuals
3,543 European ancestry individuals
IgG glycosylation
2,247 European ancestry individuals
1,848 European ancestry individuals
682 European ancestry cases, 1,300 European ancestry controls
7,759 European ancestry cases, 34,062 European ancestry controls
2,091 European ancestry cases, 8,334 European ancestry controls
6,574 European ancestry cases, 7,892 European ancestry controls
Testicular germ cell cancer
979 European ancestry cases, 4,947 European ancestry controls
664 European ancestry cases, 3,456 European ancestry controls
Vaccine-related adverse events
6 European ancestry cases,55 European ancestry controls
600 European ancestry high-performing children, 600 European ancestry low-performing children
1,954 European ancestry children
1,854 European ancestry cases, 1,894 European ancestry controls
19,879 cases and 18,761 controls of European, East Asian, African American, Latino, and Hawaiian ancestry
Corneal structure
13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals
891 Japanese ancestry cases, 3,384 Japanese ancestry controls
1,387 Japanese ancestry cases, 28,564 Japanese ancestry controls
Memory (short-term)
333 European ancestry individuals
777 European ancestry young individuals, 922 European ancestry elderly individuals
Metabolic syndrome (bivariate traits)
22,161 European ancestry individuals
Waist Circumference - Triglycerides (WC-TG)
HDL Cholesterol - Triglycerides (HDLC-TG)
Triglycerides-Blood Pressure (TG-BP)
2,323 European ancestry cases, 9,013 European ancestry controls
2,532 European ancestry cases, 5,940 European ancestry controls
2,053 European ancestry cases, 5,140 European ancestry controls
898 European ancestry cases, 1,518 European ancestry controls
801 Korean ancestry cases, 757 Korean ancestry controls
718 Korean ancestry cases, 719 Korean ancestry controls
Lapatinib-induced hepatotoxicity in breast cancer
26 European ancestry cases, 11 cases, 196 European ancestry controls, 90 controls
21 European ancestry cases, 3 cases, 123 European ancestry controls, 32 controls
778 European ancestry cases, 1,422 European ancestry controls
991 European ancestry cases, 1,489 European ancestry controls
930 European ancestry cases, 960 European ancestry controls
7,334 European ancestry cases, 5,246 European ancestry controls
2,124 cases, 6,720 controls
1,618 cases, 1,988 controls
Diabetes (gestational)
468 Korean ancestry cases, 1,242 Korean ancestry controls
931 Korean ancestry cases, 783 Korean ancestry controls
306 European ancestry cases, 15,664 European ancestry controls
311 European ancestry cases, 1,895 European ancestry controls
Lung adenocarcinoma (clinical stage)
600 European ancestry cases
317 European ancestry cases
1,019 Chinese ancestry cases, 1,710 Chinese ancestry controls
2,591 European ancestry cases, 3,052 European ancestry controls, 6,184 East Asian cases, 9,853 East Asian controls
1,453 European ancestry cases, 3,064 European ancestry controls
1,210 European ancestry cases, 2,445 European ancestry controls, 373 African American cases, 372 African American controls
1,145 European ancestry cases, 1,142 European ancestry controls
874 European ancestry cases, 1,478 European ancestry controls, 302 cases, 594 controls
28,283 European ancestry individuals
22,054 European ancestry individuals
35 Tibetan ancestry individuals
161 Tibetan ancestry individuals
24,167 European ancestry individuals
9,456 European ancestry individuals
Other erythrocyte phenotypes
Temperament (bipolar disorder)
1,263 European ancestry cases, 1,434 European ancestry controls
936 Japanese ancestry individuals
6,123 Japanese ancestry individuals
Dehydroepiandrosterone sulphate levels
14,846 European ancestry individuals
3,772 European ancestry cases, 16,033 European ancestry controls
264 Asian ancestry cases, 3,926 Asian ancestry controls
2,758 European ancestry individuals
18,554 European ancestry individuals
18,544 European ancestry individuals
Up to 1,968 European ancestry cases, 35,382 European ancestry controls
Up to 11,806 European ancestry cases, 12,387 European ancestry controls
Response to tamoxifen in breast cancer
240 Japanese ancestry female cases
222 Japanese ancestry female cases
8,656 European ancestry individuals
11,437 European ancestry individuals
Affymetrix, Illumina [~ 2261000] (imputed)
8,589 European ancestry individuals
12,981 European ancestry individuals
8,684 European ancestry individuals
9,741 European ancestry individuals
3,152 Han Chinese ancestry cases, 7,050 Han Chinese ancestry controls
1,005 European ancestry male individuals, 1,006 Indian Asian ancestry male individuals
6,827 European ancestry individuals, 2,528 Mexican ancestry individuals, 1,181 Indian Asian ancestry female individuals
Prostate cancer (SNP x SNP interaction)
4,723 European ancestry cases, 4,792 European ancestry controls
Affymetrix, Illumina [1117531] (imputed)
3,561 European ancestry cases, 4,646 European ancestry controls
6,225 European ancestry cases, 6,946 European ancestry controls, 3,064 European ancestry trios from 2,828 families
284 European ancestry male individuals
898 Korculan (founder/genetic isolate) individuals
1,084 European ancestry cases, 1,287 European ancestry controls, 4,298 European individuals
23,684 European ancestry individuals, 3,860 African American individuals
5,606 European ancestry cases, 20,565 European ancestry controls
5,419 European ancestry cases, 19,833 European ancestry controls
1,027 individuals
Diabetes (incident)
91 cases, 1,083 controls
Diabetes related insulin traits
Up to 982 individuals
1,522 European ancestry cases, 1,850 European ancestry controls
1,053 European ancestry cases, 1,858 European ancestry controls
Obesity (early onset extreme)
487 European ancestry cases, 442 European ancestry controls
2,269 European ancestry individuals from 644 families
107 Japanese ancestry cases, 107 Japanese ancestry controls
395 Japanese ancestry cases, 409 Japanese ancestry controls
891 Japanese ancestry cases, 844 Japanese ancestry controls
1,224 East Asian ancestry cases, 2,114 East Asian ancestry controls, 11,840 European ancestry cases, 10,931 European ancestry controls
386 European ancestry cases, 542 European ancestry controls
901 cases and 1,025 controls of European, Hispanic, Asian, American Indian, Pacific Islander, and other ancestries
1,431 European ancestry individuals
1,038 European ancestry cases, 1,016 European ancestry controls
831 European ancestry cases, 702 European ancestry controls
Vascular dementia
67 European ancestry cases, 5,633 European ancestry controls
256 European ancestry cases, 5,839 European ancestry controls
662 European ancestry individuals, 18 Hispanic, African American, Native American, and Asian ancestry individuals
194 European ancestry bipolar cases, 230 European ancestry schizophrenic cases, 336 European ancestry controls
435 European ancestry bipolar cases, 10,258 European ancestry controls
Asperger disorder
848 individuals from 232 families
11,536 European ancestry individuals
403 European ancestry cases, 1,670 European ancestry controls
1,578 European ancestry cases, 1,997 European ancestry controls, 2,168 cases, 3,915 controls
Glaucoma (exfoliation)
75 European ancestry cases, 14,474 European ancestry controls
199 European ancestry cases, 198 European ancestry controls
547 European ancestry cases, 548 European ancestry controls
1,151 cases from 595 families, 433 controls
1,538 Han Chinese ancestry HBV-positive HCC cases, 1,465 Han Chinese ancestry chronic HBV carriers
4,431 Han Chinese ancestry HBV-positive HCC cases, 4,725 Han Chinese ancestry chronic HBV carriers
461 European ancestry cases, 450 European ancestry controls
876 European ancestry cases, 906 European ancestry controls
1,079 European ancestry individuals from 310 families
1,341 European ancestry individuals from 310 families
Response to platinum-based chemotherapy in small-cell lung cancer
245 Han Chinese ancestry cases
183 Han Chinese ancestry cases
Non-alcoholic fatty liver disease histology (lobular)
236 European ancestry cases
Non-alcoholic fatty liver disease histology (AST)
2,325 European ancestry individuals
Rhegmatogenous retinal detachment
867 European ancestry cases, 1,953 European ancestry controls
1,966 European ancestry cases, 5,918 European ancestry controls
381 European ancestry cases, 392 European ancestry controls
1,582 European ancestry cases, 1,783 European ancestry controls
1,919 European ancestry individuals
569 female indiviuals
Alcoholism (heaviness of drinking)
2,062 European ancestry alcohol dependence cases, 6,692 European ancestry controls
3,393 European ancestry individuals
Alcoholism (12-month weekly alcohol consumption)
Alcoholism (alcohol use disorder factor score)
Alcoholism (alcohol dependence factor score)
115 African ancestry HIV-negative individuals
22,096 European ancestry individuals
Affymetrix, Illumina [~ 2661766] (imputed)
696 Japanese ancestry cases, 825 Japanese ancestry controls
130 European ancestry cases, 260 European ancestry controls
150 cases, 150 controls
1,768 European ancestry cases, 2,353 European ancestry controls
8,739 European ancestry cases, 10,831 European ancestry controls
2,000 European ancestry cases, 1,986 European ancestry controls
Up to 1,447 cases, 1,468 controls
9,126 European ancestry individuals
Freckling
Common traits (Other)
1,713 European ancestry cases, 3,978 European ancestry controls
3,361 European ancestry cases, 4,573 European ancestry controls
730 cases, 1,435 controls
571 cases, 1,806 controls
Stevens-Johnson syndrome
60 Japanese ancestry cases, 300 Japanese ancestry controls
40 cases, 608 controls
8,048 European ancestry individuals
1,376 European ancestry individuals
Psychosis (methamphetamine induced)
193 East Asian ancestry methamphetamine-dependent cases, 41 East Asian ancestry methamphetamine-dependent controls
236 Japanese ancestry cases, 864 Japanese ancestry controls
560 Japanese ancestry cases, 548 Japanese ancestry controls
1,511 Japanese ancestry cases, 2,451 Japanese ancestry controls, 479 European ancestry cases, 2,938 European ancestry controls
Vitamin D insufficiency
16,125 European ancestry individuals
17,871 European ancestry individuals
Affymetrix, Illumina [up to 2548976] (imputed)
250 Han Chinese ancestry cases, 446 Han Chinese ancestry controls
208 Han Chinese ancestry cases, 366 Han Chinese ancestry controls
Neuranatomic and neurocognitive phenotypes
857 Mexican American individuals
477 European ancestry females
854 European ancestry siblings, 762 European ancestry female individuals, 1,387 Chinese ancestry female individuals
F-cell distribution in sickle cell anaemia
440 African American individuals
Biomedical quantitative traits
591 European ancestry cases, 687 European ancestry controls
7,691 European ancestry individuals
835 European ancestry individuals
1,359 European ancestry cases, 1,400 European ancestry controls
5,048 European ancestry cases, 5,041 European ancestry controls
267 European ancestry cases, 270 European ancestry controls
695 European ancestry adult cases, 731 European ancestry adult controls, 685 European ancestry child cases, 685 European ancestry child controls
1,171 European ancestry adult cases, 1,114 European ancestry adult controls, 4,417 European ancestry adults, 896 European ancestry child cases, 1,297 European ancestry child and young adult controls, 5,291 European ancestry children
1,423 Japanese ancestry cases, 1,318 Japanese ancestry controls
484 Japanese ancestry cases, 3,974 Japanese ancestry controls
Aging
89 European ancestry and African American successfully aged individuals, 227 European ancestry Alzheimers cases
1,001 European ancestry cases, 1,033 European ancestry controls, 345 African American cases, 670 African American controls
1,550 European ancestry individuals from 250 families, 1,263 European ancestry cases, 431 European ancestry controls
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction)
46 European ancestry cases, 60 European ancestry controls, 18 cases, 14 controls
598 French Canadian founder adolescent individuals
15,842 European ancestry individuals
up to 13,602 individuals
Affymetrix, Illumina [2557000] (imputed)
875 European ancestry cases, 1,644 European ancestry controls
1,607 European ancestry cases, 6,728 European ancestry controls
2,980 European ancestry cases, 6,309 European ancestry controls
68 Finland founder cases, 136 Finland founder controls
83 Finland founder cases, 365 Finland founder controls 3,285 European ancestry cases, 6,379 European ancestry controls, 1,202 cases, 3,399 controls
Liver enzyme levels
7,751 European ancestry individuals
1,005 European ancestry individuals, 3,669 Asian Indian ancestry individuals
5,771 Japanese ancestry individuals
1,894 Japanese ancestry individuals
411 European ancestry individuals from 150 families
459 European ancestry twin pairs
965 African American cases, 1,029 African American controls
709 African American cases, 690 African American controls
Hepatitis B
179 Japanese ancestry cases, 934 Japanese ancestry controls
1,599 Japanese ancestry cases, 2,821 Japanese ancestry controls, 308 Thai ancestry cases, 546 Thai ancestry controls
Serum prostate-specific antigen levels
7,538 European ancestry individuals
2,373 European ancestry individuals
111 Malaysian Chinese ancestry cases, 260 Malaysian Chinese ancestry controls
168 Malaysian Chinese ancestry cases, 252 Malaysian Chinese ancestry controls
Quantitative traits
2,906 Kosraen individuals
2,418 European ancestry cases, 4,504 European ancestry controls
2,604 cases, 2,882 controls
381 European ancestry cases, 363 European ancestry controls, 62 cases,79 controls, 1 Asian ancestry control from 443 sibships
269 European ancestry cases, 272 European ancestry controls, 62 cases, 60 controls, 1 Asian ancestry case
2,357 European ancestry individuals, 812 African American individuals
Vascular constriction
64 European ancestry individuals
68 African America and European ancestry individuals
96 European ancestry cases, 50 European ancestry controls
31,266 European ancestry individuals
54,731 European ancestry individuals
Lupus
51 cases,114 controls
Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure)
140 child cases
981 Han Chinese ancestry cases, 1,991 Han Chinese ancestry controls
2,603 Han Chinese ancestry cases, 2,877 Han Chinese ancestry controls
12,611 European ancestry individuals
7,187 European ancestry individuals
612 Chinese ancestry cases, 1,160 Chinese ancestry controls
2,090 Chinese ancestry cases, 1,981 Chinese ancestry controls, 462 Thai ancestry cases, 951 Thai ancestry controls
Common variable immunodeficiency
179 European ancestry cases, 1,917 European ancestry controls
109 European ancestry cases, 1,114 European ancestry controls
Asparaginase hypersensitivity in acute lymphoblastic leukemia
211 European ancestry child cases, 40 Black child cases, 46 Hispanic child cases, 4 Asian ancestry child cases, 21 child cases
99 European ancestry child cases, 33 Black child cases, 24 Hispanic child cases, 2 Asian ancestry child cases, 5 child cases
Inattentive symptoms
930 European ancestry trios
Hyperactive-impulsive symptoms
755 European ancestry seroconverter cases
9,961 European ancestry individuals
6,032 European ancestry individuals
Acute lung injury
600 European ancestry cases, 2,266 European ancestry controls
212 European ancestry cases, 283 European ancestry controls
1,247 Japanese ancestry cases, 1,486 Japanese ancestry controls
4,168 Japanese ancestry cases, 5,003 Japanese ancestry controls
Neuroblastoma (high-risk)
397 European ancestry cases, 2,043 European ancestry controls
371 European ancestry cases, 2,119 European ancestry controls
7,360 European ancestry individuals
4,455 European ancestry individuals
Optic disc parameters
1,934 European ancestry individuals
Up to 3,835 European ancestry individuals
1,207 European ancestry cases, 686 European ancestry controls
122 European ancestry cases, 86 European ancestry controls
Age-related macular degeneration (smoking status interaction)
548 European ancestry ever smoking cases, 278 European ancestry ever smoking controls, 346 European ancestry never smoking cases, 247 European ancestry never smoking controls
Age-related macular degeneration (extreme sampling)
720 European ancestry grade 5 cases, 513 European ancestry grade 1 controls
70 European ancestry grade 5 cases, 73 European ancestry grade 1 controls
1,621 extreme cases, 1,699 controls
19,845 extreme cases, 16,541 controls
Aspirin intolerance in asthmatics
80 Korean ancestry cases, 100 Korean ancestry controls
163 Korean ancestry cases, 429 Korean ancestry controls
Response to antidepressant treatment
700 European ancestry cases
832 European ancestry cases, 366 European ancestry controls
Cortisol secretion
1,711 European ancestry individuals
2,836 European ancestry individuals
4,533 European ancestry cases, 10,750 European ancestry controls
4,918 European ancestry cases, 5,684 European ancestry controls
8,625 European ancestry cases, 9,657 European ancestry controls
706 European ancestry individuals
101 European ancestry cases, 101 European ancestry controls
704 European ancestry individuals, 1,467 African American individuals
up to 101,069 European ancestry individuals
25,490 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 2309290] (imputed)
up to 126,559 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 23218963] (imputed)
29,136 European ancestry individuals
Affymetrix, Illumina [2533153] (imputed)
501 European ancestry type 2 diabetes female cases, 504 European ancestry female controls
518 European ancestry female individuals
Brain structure
740 European ancestry individuals
1,033 European ancestry cases, 3,733 European ancestry controls
Attention deficit hyperactivity disorder (time to onset)
64 Japanese ancestry responders, 78 Japanese ancestry non-responders
122 Japanese ancestry responders, 50 Japanese ancestry non-responders
Beta thalassemia/hemoglobin E disease
235 Thai-Chinese ancestry mild cases, 383 Thai-Chinese ancestry severe cases
52 Indonesian ancestry mild cases, 122 Indonesian ancestry severe cases
324 European ancestry cases, 2,999 European ancestry controls
75 European ancestry atopy and asthma cases, 75 European ancestry atopy only cases, 75 European ancestry controls
429 European ancestry atopy cases, 222 European ancestry controls
Brain imaging
175 European ancestry Alzheimer cases, 354 European ancestry amnestic mild cognitive impairment cases, 204 European ancestry controls
4,300 Sardinian individuals
1,860 Sardinian individuals, 832 Old Order Amish individuals
15,297 European ancestry female individuals
10,040 European ancestry female individuals
Heart rate variability traits
472 European ancestry individuals from 99 families
988 Japanese ancestry cases, 2,521 Japanese ancestry controls
933 Japanese ancestry cases, 15,753 Japanese ancestry controls
314 Chinese ancestry cases, 1,484 Chinese ancestry controls
2,630 Chinese ancestry cases, 2,155 Chinese ancestry controls, 314 Thai ancestry cases, 519 Thai ancestry controls
296 European ancestry cases, 347 European ancestry controls
319 European ancestry cases, 234 European ancestry controls
11,847 European ancestry individuals
11,024 European ancestry individuals, 3,843 African American individuals
1,786 Filipino ancestry female individuals
1,679 Filipino ancestry offspring
45 Korean ancestry cases, 48 Korean ancestry controls
20,288 European ancestry individuals
up to 54,276 European ancestry individuals
200 Japanese ancestry cases, 200 Japanese ancestry controls
4,818 European ancestry individuals
Social and non-social autistic-like traits
1,462 European ancestry individuals
3,494 European ancestry individuals
Up to 74,035 European ancestry individuals
Up to 68,988 participants
399 European ancestry cases, 1,318 European ancestry controls
655 European ancestry triads
1,235 European ancestry cases, 1,433 European ancestry controls, 662 African American cases, 499 African American controls
219 European ancestry families, 35 African American families, 4 families, 487 European ancestry cases, 1,358 European ancestry controls
178 European ancestry antibody-positive individuals, 184 European ancestry antibody-negative individuals
350 European ancestry antibody-positive individuals, 468 European ancestry antibody-negative individuals
Folate pathway vitamin levels
3,305 European ancestry females, 1,458 European ancestry males
Asthma or atopy (farm exposure interaction)
850 European asthmatic child cases, 348 European atopic child cases, 510 European child controls
2,116 European ancestry cases, 7,318 European ancestry controls, 330 Dutch founder cases, 1,216 Dutch founder controls
2,957 European ancestry cases, 5,774 European ancestry controls
Autism spectrum disorders (language delay)
42 Korean ancestry male cases and their parental controls
2,101 East Asian ancestry cases, 282 Japanese ancestry controls
Acenocoumarol maintenance dosage
1,451 European ancestry individuals
287 individuals
720 European ancestry female cases, 2,337 European ancestry female controls
1,846 European ancestry female cases, 1,825 European ancestry female controls
1,675 European ancestry cases, 5,903 European ancestry controls
169 European ancestry cases, 927 European ancestry controls
744 Han Chinese ancestry cases, 895 Han Chinese ancestry controls
3,338 Han Chinese ancestry cases, 5,792 Han Chinese ancestry controls
807 European ancestry cases, 1,074 European ancestry controls
363 European ancestry cases, 355 European ancestry controls, 133 African American cases, 144 African American controls, 561 Asian ancestry cases, 605 Asian ancestry controls
2,559 European ancestry individuals
1,599 European ancestry cases, 11,546 European ancestry controls
2,954 European ancestry cases, 5,967 European ancestry controls, Up to 561 Japanese ancestry cases, Up to 565 Japanese ancestry control, Up to 422 African American cases, Up to 448 African American controls, Up to 418 Hispanic cases, Up to 422 Hispanic controls, Up to 148 cases, Up to 293 controls
1,235 European ancestry cases, 1,599 European ancestry controls
1,032 European ancestry cases, 571 European ancestry controls, 210 African American cases, 346 African American controls
96,598 European ancestry individuals
100,184 European ancestry individuals
95,454 European ancestry individuals
99,900 European ancestry individuals
931 European ancestry trios, 2,431 European ancestry controls
609 European ancestry trios, 2,322 European ancestry cases, 2,987 European ancestry controls
1,505 Chinese ancestry cases, 1,522 Chinese ancestry controls
5,026 Chinese ancestry cases, 2,476 Chinese ancestry controls, 1,591 European ancestry cases, 1,466 European ancestry controls
501 European ancestry female individuals, 499 European ancestry male individuals
1,216 European ancestry female individuals
2,663 European ancestry cases, 13,498 European ancestry controls
10,282 European ancestry cases, 21,093 European ancestry controls
172 European ancestry Alzheimer's disease cases, 109 European ancestry mild cognitive impairment cases, 109 European ancestry controls
Hair morphology
4,845 European ancestry individuals from 2,892 families, 16,140 European ancestry individuals
Subclinical atherosclerosis traits (other)
Up to 984 individuals
Up to 678 individuals
Coronary spasm
50 Japanese ancestry female cases, 50 Japanese ancestry female controls
151 Japanese ancestry female cases, 160 Japanese ancestry female controls
692 European ancestry cases, 3,992 European ancestry controls
176 cases, 174 controls
3,322 European ancestry cases, 3,587 European ancestry controls
4,692 European ancestry cases, 15,493 European ancestry controls
Volumetric brain MRI
705 European ancestry individuals
Cognitive test performance
694 European ancestry individuals
Exercise treadmill test traits
Up to 1,238 European ancestry individuals
Echocardiographic traits
Endothelial function traits
1,311 European ancestry cases, 3,340 European ancestry controls
793 European ancestry cases, 857 European ancestry controls
3,101 European ancestry individuals from 780 families, 1,204 European ancestry cases, 6,491 European ancestry controls
1,390 European ancestry individuals from 447 families, 108 European ancestry cases, 540 European ancestry controls
747 European ancestry individuals from 307 families
1,951 European ancestry individuals from 355 families
1,081 European ancestry individuals from 200 sibships
90 Hispanic and European ancestry cases, 90 Hispanic and European ancestry controls
30 Hispanic and European ancestry cases, 1,652 Hispanic and European ancestry controls
Primary tooth development (number of teeth)
11,513 European ancestry individuals
2,296 European ancestry cases, 5,171 European ancestry controls
2,753 European ancestry cases, 4,569 European ancestry controls
979 European ancestry individuals
1006 European ancestry individuals
Primary tooth development (time to first tooth eruption)
11,118 European ancestry individuals
Optic nerve measurement (cup area)
1,368 European ancestry twins from 666 families
848 European ancestry twins from 531 families
Optic nerve measurement (rim area)
Optic nerve measurement (disc area)
Optic nerve measurement (cup-to-disc ratio)
2,780 European ancestry cases, 12,515 European ancestry controls
3,111 Japanese ancestry cases, 1,666 Japanese ancestry controls
3,659 European ancestry cases, 4,897 European ancestry controls
12,576 European ancestry cases, 12,223 European ancestry controls
336 European ancestry iron deficiency cases, 343 European ancestry controls
71 European ancestry iron deficiency cases, 161 European ancestry controls
Iron deficiency
336 European ancestry cases, 343 European ancestry controls
71 European ancestry cases, 161 European ancestry controls
4,501 European ancestry individuals
2,221 European ancestry individuals
1,139 Han Chinese ancestry cases, 1,132 Han Chinese ancestry controls
5,721 Chinese ancestry cases, 7,340 Chinese ancestry controls
Large B-cell lymphoma
74 Japanese ancestry cases, 934 Japanese ancestry controls
325 Japanese ancestry cases, 3,309 Japanese ancestry controls
Attention deficit hyperactivity disorder motor coordination
890 European ancestry children
296 European ancestry children
10,623 European ancestry individuals
27,591 European ancestry individuals, 1,415 Filipino ancestry individuals, 746 North African ancestry individuals, 333 Turkish ancestry individuals
6,668 European ancestry individuals
Cardiac muscle measurement
1,258 Black individuals
989 Black individuals, 1,316 European ancestry individuals
Insulin-like growth factors
452 European ancestry cases, 14,378 European ancestry controls
301 European ancestry cases, 1,419 European ancestry controls
Carotenoid and tocopherol levels
1,191 European ancestry individuals
2,540 European ancestry individuals, 211 individuals
7,073 European ancestry cases, 7,325 European ancestry controls
820 European ancestry cases, 885 European ancestry controls
1,304 European ancestry individuals
5-HTT brain serotonin transporter levels
16 European, African American and Hispanic unmedicated bipolar disorder cases, 17 European, African American and Hispanic unmedicated major depressive disorder cases, 22 controls
51 European ancestry individuals
842 Punjabi Sikh ancestry type 2 diabetes cases, 774 Punjabi Sikh ancestry controls
1,108 Punjabi Sikh ancestry type 2 diabetes cases, 1,289 Punjabi Sikh ancestry controls, 2,952 European ancestry myocardial infarction cases and healthy controls, 10,033 European ancestry individuals
Functional MRI
36 European ancestry BD cases, 21 European ancestry controls, 1 African American BD case, 5 African American controls, 2 BD cases, 3 controls
1,984 European ancestry individuals
3,761 European ancestry individuals, 1,248 individuals
14 Sardinian cases, 23 Sardinian controls
26,316 European ancestry individuals
21,185 European ancestry individuals
8,531 European ancestry individuals
6,202 European ancestry individuals
Up to 1,327 individuals
Tonometry
644 individuals
1,086 African American individuals
Major CVD
142 cases and 1,203 controls from 310 families
151 cases and 1,190 controls from 310 families
75 cases and 1,272 controls from 310 families
8 Japanese ancestry cases
16 Japanese ancestry cases
597 European ancestry cases, 1,295 European ancestry controls
409 European ancestry cases, 541 European ancestry controls
1,968 African American cases, 3,928 African American controls
Up to 1,141 individuals from 241 families
Hip geometry
Up to 1,094 individuals from 241 families
8,130 European ancestry cases, 38,987 European ancestry controls
Up to 34,412 European ancestry cases, 59,925 European ancestry controls
Affymetrix, Illumina [2426886] (imputed)
706 Han Chinese ancestry cases, 1,225 Han Chinese ancestry controls
3,254 Chinese ancestry cases, 5,955 Chinese ancestry controls
6,316 European ancestry individuals, 9,685 Indian Asian ancestry individuals
5,187 European ancestry individuals, 6,721 Indian Asian ancestry individuals
Response to acetaminophen (hepatotoxicity)
60 European ancestry lymphoblastoid cell lines, 56 African American lymphoblastoid cell lines, 60 Han Chinese American lymphoblastoid cell lines
706 Han Chinese ancestry cases, 5,581 Han Chinese ancestry controls
3,301 Han Chinese ancestry cases, 5,299 Han Chinese ancestry controls
2,839 European ancestry cases, 3,507 European ancestry controls
9,041 European ancestry cases, 8,980 European ancestry controls
Cystatin C levels
981 individuals
883 individuals
822 individuals
316 cases, 229 controls
55 Asian ancestry cases, 134 Asian ancestry controls, 1,382 European ancestry cases, 1,428 European ancestry controls, 184 Black cases, 127 Black controls, 42 cases, 87 controls
Tardive dyskinesia in schizophrenia
88 European ancestry cases, 40 African American cases, 3 cases, 129 European ancestry controls, 62 African American controls, 5 controls
44 Ashkenazi Jewish Israeli cases, 33 Jewish Israeli cases, 52 Ashkenazi Jewish Israeli controls, 41 Jewish Israeli controls
Lymphoma
275 Follicular non-Hodgkin's Lymphoma cases, 269 diffuse large B-cell non-Hodgkin's Lymphoma cases, 198 other non-Hodgkin's Lymphoma cases, 202 Hodgkin's Lymphoma cases, 4,044 controls
202 European ancestry Follicular non-Hodgkin's Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin's Lymphoma cases, 577 European ancestry other non-Hodgkin's Lymphoma cases, 99 European ancestry Hodgkin's Lymphoma cases, 2,596 European ancestry controls
1,902 European ancestry cases, 1,929 European ancestry controls
18,284 European ancestry cases, 18,926 European ancestry controls
504 Han Chinese ancestry cases, 2,947 Han Chinese ancestry controls
583 Han Chinese ancestry cases, 497 Han Chinese ancestry controls
1,017 African American individuals
537 European ancestry cases, 1,984 European ancestry controls
2,741 European ancestry cases, 2,875 European ancestry controls
279 European ancestry cases, 515 European ancestry controls
1,757 European ancestry cases, 1,540 European ancestry controls
181 Chinese ancestry cases, 346 Chinese ancestry controls
190 Chinese ancestry cases, 510 Chinese ancestry controls
112 European ancestry individuals
Iris color
925 Erasmus Rucphen individuals, 481 European ancestry females
5,575 European ancestry individuals, 1,292 Erasmus Rucphen individuals
6,687 European ancestry cases, 19,718 European ancestry controls
9,628 European ancestry cases, 12,917 European ancestry controls
20 Han Chinese ancestry male gout cases, 42 Han Chinese ancestry male controls
1,854 European ancestry cases, 21,372 European ancestry controls
8,239 European ancestry cases, 7,590 European ancestry controls
3,925 European ancestry individuals
Up to 39,859 European ancestry individuals, Up to 1,148 African American individuals
1,580 European ancestry cases, 6,276 European ancestry controls
495 Japanese ancestry cases, 676 Japanese ancestry controls
871 European ancestry cases, 863 European ancestry controls
1,460 European ancestry cases, 12,995 European ancestry controls
9,392 European ancestry individuals
12,118 European ancestry individuals, 5,212 East Asian ancestry individuals
59 cases, 558 controls
58 cases, 665 controls
Environmental confusion in the home
469 European ancestry children from low chaos families, 369 European ancestry children from high chaos families
3,529 European ancestry children
Myocardial infarction (early onset)
2,967 European ancestry cases, 3,075 European ancestry controls
9,746 European ancestry cases, 9,746 European ancestry controls
32,387 European ancestry individuals
59,082 European ancestry individuals
Affymetrix, Illumina [2399588] (imputed)
45 European ancestry cases,195 European ancestry controls
1,316 European ancestry cases, 1,423 European ancestry controls, 1,318 cases and 1,507 controls from 756 families
1,804 European ancestry individuals
3,266 European ancestry individuals
YKL-40 levels
632 Hutterite individuals
443 European ancestry cases, 491 European ancestry controls, 206 European ancestry individuals
855 European ancestry breast cancer cases
154 European ancestry breast cancer cases, 117 African American breast cancer cases
978 European ancestry cases, 883 European ancestry controls
Multiple sclerosis (age of onset)
Normalized brain volume
753 European ancestry cases, 883 European ancestry controls
Brain lesion load
791 European ancestry cases, 883 European ancestry controls
794 European ancestry cases, 883 European ancestry controls
Aging traits
1,345 individuals from 330 families
Morbidity-free survival
558 individuals
3,177 European ancestry cases, 4,894 European ancestry controls
10,312 European ancestry cases, 45,861 European ancestry controls, 213 cases, 2,531 controls
Parkinson's disease (familial)
1,119 European ancestry cases, 1,127 European ancestry controls
1,418 European ancestry children, 134 European ancestry adult individuals
3,875 European ancestry children
4,549 European ancestry cases, 5,579 European ancestry controls
24,194 European ancestry cases, 55,598 European ancestry controls
Affymetrix, Illumina [2202892] (imputed)
72,598 European ancestry individuals, 1,160 African American individuals
Up to 11,036 European ancestry individuals, 32,615 individuals
574 European ancestry trios, 605 European ancestry controls
1,501 European ancestry cases, 11,290 European ancestry controls
1,992 European ancestry cases, 3,058 European ancestry controls
4,364 East Asian ancestry cases, 24,174 European ancestry controls, 3,564 East Asian ancestry controls, 24,391 European ancestry controls
Atrial fibrillation/atrial flutter
550 European ancestry cases, 4,476 European ancestry controls
3,030 European ancestry cases, 14,780 European ancestry controls, 333 Han Chinese ancestry cases, 2,836 Han Chinese ancestry controls
Up to 5,633 European ancestry individuals
Up to 3,457 European ancestry individuals
347 Finnish Saami individuals
Celiac disease or Rheumatoid arthritis
4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls
2,169 European ancestry celiac disease cases, 2,845 European ancestry rheumatoid arthritis cases, 7,199 European ancestry controls
Bipolar disorder (age of onset and psychotic symptoms)
2,836 European ancestry cases, 2,744 European ancestry controls
3,916 European cases, 5,112 controls
Affymetrix, Illumina [2373895] (imputed)
Carotid atherosclerosis in HIV infection
177 European ancestry individuals
995 Han Chinese ancestry cases, 894 Han Chinese ancestry controls
1,803 Han Chinese ancestry cases, 1,473 Han Chinese ancestry controls
1,721 Korean ancestry male individuals
1,113 Korean ancestry male individuals
6,543 Indian Asian ancestry individuals
6,243 Indian Asian ancestry individuals, 5,370 European ancestry individuals
Natriuretic peptide levels
1,325 European ancestry individuals
1,746 European ancestry individuals
Heroin addiction
200 European ancestry cases, 150 European ancestry controls, 125 African American cases, 100 African American controls
HIV (mother-to-child transmission)
100 Malawian ancestry infant cases, 126 Malawian ancestry infant controls
260 African American cases, 5,053 African American controls
621 African American cases, 1,629 African American controls
1,264 African American cases, 5,678 African American controls
503 African American cases, 1,656 African American controls
7,565 African American individuals
3,789 African American and Afro-Caribbean individuals
7,813 African American individuals
4,323 African American and Afro-Caribbean individuals
4,069 African American cases, 3,848 African American controls
1,372 African American cases, 1,482 African American controls
Migraine in psychiatric disorder
56 European ancestry bipolar disorder cases, 699 European ancestry bipolar disorder controls
131 European ancestry attention deficit hyperactivity disorder cases, 324 European ancestry attention deficit hyperactivity disorder controls
405 European ancestry cases, 497 European ancestry controls
1,752 European ancestry cases, 1,745 European ancestry controls
477 Ashkenazi Jewish cases, 524 Ashkenazi Jewish controls
203 Ashkenazi Jewish cases, 263 Ashkenazi Jewish contols
Beta-trace protein levels
6,720 European ancestry individuals
1,734 African American individuals
Follicular lymphoma
681 European ancestry cases, 750 European ancestry controls
up to 3,164 European ancestry cases, 6,208 European ancestry controls
Cardiovascular risk factors (age interaction)
525 European ancestry individuals
2,442 Finnish ancestry individuals
Cardiovascular risk factors
189 European ancestry cases, 592 European controls
456 European ancestry cases, 2,785 European ancestry controls
350 Han Chinese ancestry cases, 350 Han Chinese ancestry controls
390 Han Chinese ancestry cases, 516 Han Chinese ancestry controls
1,077 Han Chinese ancestry cases, 1,733 Han Chinese ancestry controls
7,673 Han Chinese ancestry cases, 11,013 Han Chinese ancestry controls, 303 Uygur-Kazakh Chinese ancestry cases, 537 Uygur-Kazakh Chinese ancestry controls
6,688 European ancestry cases, 13,685 European ancestry controls
13,182 European ancestry cases, 26,161 European ancestry controls
1,583 Chinese ancestry cases, 1,894 Chinese ancestry controls
3,507 Chinese ancestry cases, 3,063 Chinese ancestry controls, 284 Chinese ancestry trios
453 European ancestry cases, 945 European ancestry controls,
481 European ancestry cases, 3,706 European ancestry controls
Creutzfeldt-Jakob disease (variant)
93 European ancestry cases, 1,504 European ancestry controls
42 European ancestry cases
Ankle-brachial index
38,376 European ancestry individuals, 2,133 Erasmus Rucphen individuals, 1,183 Old Order Amish individuals
16,717 European ancestry individuals
Up to 3,925 European individuals
1,079 South Tyrolean individuals, 790 Dutch founder individuals, 2,060 European ancestry individuals
Multiple sclerosis--Brain Glutamate Levels
382 cases
Electrocardiographic conduction measures
1,262 Kosraen individuals
492 Mexican ancestry trios
177 Mexican ancestry trios
343 European ancestry cases, 250 European ancestry controls, 54 controls
283 European ancestry cases, 972 European ancestry controls
155 European ancestry cases, 341 European ancestry controls
2,557 European ancestry individuals from 750 families
53 Korean ancestry cases, 240 Korean ancestry controls
37 Korean ancestry cases
767 European ancestry cases, 1,422 European ancestry controls
1,643 European ancestry cases, 3,406 European ancestry controls
12,612 European ancestry individuals
4,094 European ancestry individuals
Glycemic control in type 1 diabetes (HbA1c)
667 European ancestry conventional treatment cases, 637 European ancestry intensive treatment cases
1,382 European ancestry cases
Affymetrix, Illumina [2518578] (imputed)
794 European ancestry individuals
Osteosarcoma
694 European ancestry cases, 2,703 European ancestry controls
247 European ancestry cases, 550 European ancestry controls
1,817 European ancestry cases, 2,353 European ancestry controls
6,944 European ancestry cases, 9,477 European ancestry controls
3,941 European ancestry cases, 3,964 European ancestry controls
685 European ancestry individuals with type 1 diabetes
477 European ancestry individuals
285 European ancestry cases, 298 European ancestry controls
766 European ancestry cases, 2,935 European ancestry controls
297 Japanese ancestry cases, 934 Japanese ancestry controls
533 Japanese ancestry cases, 977 Japanese ancestry controls
1,803 European ancestry cases, 34,336 European ancestry controls
2,165 European ancestry cases, 3,800 European ancestry controls
41,150 European ancestry individuals
120,516 European ancestry individuals
896 European ancestry cases, 2,916 European ancestry controls
1,644 European ancestry individuals
9,947 European ancestry individuals
Serum selenium levels
582 European ancestry individuals
621 European ancestry individuals
2,038 European ancestry female individuals, 1,531 European ancestry male individuals
5,595 European ancestry female individuals, 2,126 European ancestry male individuals
4,110 European ancestry individuals
364 European ancestry cases, 364 European ancestry controls, 13 cases, 13 controls
446 European ancestry cases, 853 European ancestry controls, 65 cases, 154 controls
987 European ancestry individuals
1,488 European ancestry individuals, 2,118 Chinese ancestry individuals
Pulmonary function (smoking interaction)
50,047 European ancestry individuals
1,636 European ancestry cases, 1,594 European ancestry controls
1,418 European ancestry cases, 1,918 European ancestry controls
1,117 Han Chinese ancestry cases, 1,429 Han Chinese ancestry controls
6,623 East Asian ancestry cases, 10,740 East Asian ancestry controls
2,934 European ancestry individuals
686 European ancestry individuals
3,558 European ancestry individuals
29,527 European ancestry individuals
Affymetrix, Illumina [~ 2399142] (imputed)
8,424 European ancestry cases, 7,268 European ancestry controls, 6,996 South Asian ancestry cases, 7,794 South Asian ancestry controls
18,049 European ancestry cases, 16,357 European ancestry controls, 3,359 South Asian ancestry cases, 2,828 South Asian ancestry controls
1,836 European ancestry long-lived individuals, 1,955 European ancestry controls
2,594 European ancestry long-lived individuals, 3,431 European ancestry controls
Affymetrix, Illumina [2287520] (imputed)
Event-related brain oscillations
431 European ancestry alcohol dependence cases, 340 European ancestry controls, 209 African American alcohol dependence cases, 84 African American controls
683 alcohol dependence cases and 412 controls from multiplex families
Insulin-related traits
814 Hispanic family members
22,233 European ancestry cases, 64,762 European ancestry controls
56,682 European ancestry cases and controls
Affymetrix, Illumina [~ 2300000] (imputed)
979 cases, 1,709 controls
868 European ancestry cases, 410 European ancestry controls, 4,921 cases, 3,824 controls
Suicide attempts in bipolar disorder
1,201 European and unknown ancestry attempters, 1,497 European and unknown ancestry non-attempters
1,295 attempters, 1,822 non-attempters
Affymetrix, Illumina [2408051] (imputed)
4,275 Korean ancestry individuals
3,782 Korean ancestry individuals
4,300 Sardinian indivduals
1,164 European ancestry individuals, 1,136 Old Order Amish individuals, 1,858 Sardinian individuals
Erectile dysfunction and prostate cancer treatment
27 African American cases, 52 African American controls
986 European ancestry cases, 1,846 European ancestry controls
391 European ancestry cases, 213 European ancestry controls
Response to platinum-based chemotherapy in non-small-cell lung cancer
327 European ancestry individuals
735 European ancestry individuals
Up to 4,039 European ancestry individuals
506 European ancestry bipolar 1 disorder cases, 523 European ancestry schizophrenia cases, 505 European ancestry controls
14,618 European ancestry females
1,509 European ancestry cases, 5,380 European ancestry controls
971 European ancestry cases, 1,990 European ancestry controls
9,464 individuals
Affymetrix, Illumina [2555103] (imputed)
487 European ancestry obese individuals, 472 non-obese individuals
19,840 European ancestry individuals
Up to 20,623 European ancestry individuals
131 Japanese ancestry cases, 135 Japanese ancestry controls
776 Japanese ancestry cases, 5,205 Japanese ancestry controls
973 European ancestry cases, 1,856 European ancestry controls
Atrioventricular conduction
2,334 European ancestry individuals
1,776 Filipino ancestry female individuals
1,774 Filipino ancestry offspring
Biochemical measures
492 European ancestry cases, 496 European ancestry controls
238 European ancestry cases, 220 European ancestry controls
1,470 European ancestry cases
Alcohol consumption (transferrin glycosylation)
5,181 European ancestry individuals
2,284 European ancestry individauls
1,856 European ancestry cases, 4,955 European ancestry controls
5,015 European ancestry cases, 11,601 European ancestry controls
815 Hispanic children
1,383 European ancestry cases, 996 European ancestry controls, 683 African American cases, 2,635 African American controls
2,116 European ancestry individuals, 4,496 African American individuals
474 West African ancestry cases, 458 West African ancestry controls
5,096 African American cases, 4,972 African American controls
Body mass index in non-asthmatics
6,025 European ancestry children, 567 children, 6,334 European ancestry adult individuals, 2,050 adult individuals
Body mass index in asthmatics
1,881 European ancestry children, 810 children, 2,643 European ancestry adult individuals, 817 adult individuals
979 European ancestry children, 921 Hispanic children, 120 children
1,218 European ancestry cases, 990 European ancestry controls, 139 cases, 114 controls
3,895 European ancestry individuals
14,810 individuals
4,243 European ancestry cases
4,243 European ancestry cases, 5,112 European ancestry controls
Amyotrophic lateral sclerosis (C9orf72 mutation interaction)
Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals
Up to 4,243 European ancestry cases, up to 5,112 European ancestry controls
Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals
1,121 European ancestry cases, 3,745 European ancestry controls
861 European ancestry cases, 2,033 European ancestry controls
Affymetrix, Illumina [~ 1500000] (imputed)
Metabolite levels (HVA/5-HIAA ratio)
up to 398 European ancestry individuals
Metabolite levels (HVA-5-HIAA Factor score)
Metabolite levels (HVA)
Metabolite levels (5-HIAA)
Metabolite levels (MHPG)
Metabolite levels (5-HIAA/ MHPG Ratio)
Metabolite levels (HVA/MHPG ratio)
952 African American cases, 988 African American controls
640 African American cases, 683 African American controls
Response to fenofibrate (adiponectin levels)
793 European ancestry individuals
9,772 European ancestry cases, 16,849 European ancestry controls
4,218 European ancestry cases, 7,296 European ancestry controls
Bipolar disorder (Negative mood delusions)
927 European ancestry cases, 2,168 European ancestry controls
1,247 European ancestry cases, 1,434 European ancestry controls
133,154 European ancestry individuals
59,325 European ancestry individuals
Affymetrix, Illumina, Perlegen [~ 2440000] (imputed)
Up to 9,103 Japanese ancestry individuals
Up to 1,629 Japanese ancestry individuals
3,931 European ancestry individuals
1,418 European ancestry individuals
74,064 European ancestry individuals
48,607 European ancestry individuals
1,069 European ancestry cases, 2,958 European ancestry controls, 45 cases, 329 controls
1,051 European ancestry cases, 3,560 European ancestry controls
16,175 European ancestry female individuals
196 European ancestry lethal cases, 368 European ancestry long-term survivor cases
500 European ancestry lethal cases, 155 European ancestry long-term survivor cases
455 African American individuals
1,086 Japanese ancestry cases, 1,816 Japanese ancestry controls
1,653 Japanese ancestry cases, 2,797 Japanese ancestry controls
LDL (oxidized)
4,238 European ancestry individuals
Drinking behavior
1,420 Han Chinese ancestry cases, 3,590 Han Chinese ancestry controls
4,896 Han Chinese ancestry cases, 13,293 Han Chinese ancestry controls
842 Punjabi Sikh ancestry cases, 774 Punjabi Sikh ancestry controls
up to 2,512 Punjabi Sikh ancestry cases and 3,201 Punjabi Sikh ancestry controls, up to 16,128 South Asian ancestry cases and 23,846 South Asian ancestry controls, up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls, up to 8,130 European ancestry cases and 38,987 European ancestry controls
388 Korean ancestry cases, 739 Korean ancestry controls
810 Korean ancestry cases, 1709 Korean ancestry controls
417 Korean ancestry cases, 732 Korean ancestry controls
1,419 European ancestry cases from 1416 families
1,314 European ancestry cases from 1301 families
Stroke (pediatric)
270 European ancestry trios
1,064 European ancestry cases, 10,082 European ancestry controls
367 Korean ancestry cases, 800 Korean ancestry controls
363 Japanese ancestry cases, 272 Japanese ancestry controls
Sunburns
9,283 European ancestry individuals
4,236 European ancestry individuals
Affymetrix, Illumina [7588169] (imputed)
3871 European ancestry individuals
2,496 European ancestry individuals
Affymetrix, Illumina [2469762] (imputed)
7,070 European ancestry individuals
4,155 European ancestry individuals
6,747 European ancestry individuals
2,078 European ancestry individuals
9,678 European ancestry individuals
Periodontal microbiota
1,020 European ancestry individuals
3,425 African American cases, 3,290 African American controls
1,500 African American/Afro-Caribbean cases, 1,908 African American/Afro-Caribbean controls, 344 Sub-Saharan African ancestry cases, 1,361 Sub-Saharan African ancestry controls
Response to fenofibrate
817 European ancestry individuals
1,268 European, South Asian, East Asian, African American/Afro-Caribbean, Hispanic and other ancestry cases
1,267 European, South Asian, East Asian, African American/Afro-Caribbean, Hispanic and other ancestry cases
147 Han Chinese ancestry cases, 951 Han Chinese ancestry controls
554 Han Chinese ancestry cases, 1,159 Han Chinese ancestry controls
806 Japanese ancestry cases, 1,337 Japanese ancestry controls
3,593 Japanese ancestry cases, 6,335 Japanese ancestry controls
Circulating myeloperoxidase levels (serum)
9,305 European ancestry individuals
Circulating myeloperoxidase levels (plasma)
9,260 European ancestry individuals
Erythrocyte sedimentation rate
1,979 European ancestry individuals
5,628 European ancestry individuals
Preeclampsia
538 European ancestry cases, 540 European ancestry controls
1,894 European ancestry cases, 3,022 European ancestry controls
2,025 European ancestry cases, 5,328 European ancestry controls
7,913 European ancestry cases, 10,417 European ancestry controls
Cholelithiasis-related traits in sickle cell anemia
905 African American cases
2,152 African American cases
772 European ancestry cases, 2,024 European ancestry controls
Caffeine consumption
47,431 European ancestry individuals
5,244 European ancestry individuals
10,754 individuals
29,347 European ancestry individuals, 4,232 African American individuals, 1,776 Filipino ancestry individuals
29,347 European ancestry individuals
10,536 European ancestry individuals
Liver enzyme levels (alanine transaminase)
Up to 52,350 European ancestry individuals, up to 8,739 Indian Asian ancestry individuals
Liver enzyme levels (alkaline phosphatase)
Liver enzyme levels (gamma-glutamyl transferase)
3,750 Han Chinese ancestry cases, 6,468 Han Chinese ancestry controls
4,383 Han Chinese ancestry cases, 4,539 Han Chinese ancestry controls
1,215 Turkish ancestry cases, 1,278 Turkish ancestry controls
Up to 111 Turkish ancestry cases, 225 Turkish ancestry controls, 189 Middle Eastern Arab ancestry cases, 163 Middle Eastern Arab ancestry controls, 227 European ancestry cases, 203 European ancestry controls, 688 East Asian ancestry cases, 791 East Asian ancestry controls
Response to platinum-based chemotherapy in small cell and non-small cell lung cancers
91 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese ancestry lymphoblastoid cell lines
222 European ancestry small cell lung cancer cases, 961 European ancestry non-small cell lung cancer cases
Disc degeneration (lumbar)
4,683 European ancestry individuals
Affymetrix, Illumina [2552511] (imputed)
Breast cancer (male)
823 European ancestry cases, 2,795 European ancestry controls
438 European ancestry cases, 474 European ancestry controls
5,388 European ancestry individuals
4,071 European ancestry individuals
Affymetrix, Illumina [2558979] (imputed)
7,605 Japanese ancestry cases, 3,534 Japanese ancestry controls
1,094 European ancestry triads, 1,277 Asian ancestry triads, 87 triads
802 Han Chinese ancestry cases, 1,863 Han Chinese ancestry controls
1,424 Han Chinese ancestry cases, 2,713 Han Chinese ancestry controls
Vitamin E levels
2,402 European ancestry cases, 1612 European ancestry controls
475 European ancestry cases, 517 European ancestry controls, 1,416 cases, 1,359 controls
63 Chinese ancestry dizygotic twin pairs
Head circumference (infant)
10,768 European ancestry infants
8,321 European ancestry infants
Partial epilepsies
Up to 3,445 European ancestry cases, 6,935 European ancestry controls
418 European ancestry cases, 2,810 European ancestry controls
1,377 European ancestry cases, 1,284 European ancestry controls
HPV seropositivity
1,286 European ancestry lung cancer cases, 679 European ancestry head and neck cancer cases, 811 European ancestry kidney cancer cases, 2,035 European ancestry controls
1,307 Hispanic head and neck cancer cases, 1,037 Hispanic controls
Neonatal lupus
116 European ancestry cases, 3,351 European ancestry controls
Wilms tumor
757 European ancestry cases, 1,879 European ancestry controls
1,488 European ancestry cases, 3,851 European ancestry controls
263 Amish individuals aged 80 years or older
6,706 European individuals from 2,585 independent families
928 French Canadian individuals
Age-related macular degeneration (wet)
96 South East Asian ancestry cases, 130 South East Asian ancestry controls
Esophageal cancer and gastric cancer
1,625 Chinese ancestry gastric cancer cases, 1,898 Chinese ancestry ESCC cases, 2,100 Chinese ancestry controls
896 European ancestry cases, 2,455 European ancestry controls
Up to 32,389 African American individuals
Affymetrix, Illumina [~ 2900000] (imputed)
3,248 European ancestry individuals
659 European ancestry individuals
3,548 European ancestry cases, 5,972 European ancestry controls
6,594 European ancestry cases, 34,864 European ancestry controls
Chronic kidney disease and serum creatinine levels
1,689 European ancestry cases, 37,076 European ancestry controls
1,972 European ancestry cases, 6,125 European ancestry controls
Sex ratio at birth
61,094 European ancestry female individuals, 53,769 European ancestry male individuals
Affymetrix, Illumina [2623828] (imputed)
Influenza (severity)
25 Chinese ancestry severe cases, 26 Chinese ancestry controls
152 Chinese ancestry severe cases, 222 Chinese ancestry controls
Aspirin hydrolysis (plasma)
2,054 European ancestry individuals
6,713 European ancestry cases, 48,402 European ancestry contols, 110 Southern Indian ancestry cases, 119 Southern Indian ancestry controls, 827 Japanese ancestry cases, 3,323 Japanese ancestry controls
9,070 European ancestry cases, 7,683 European ancestry contols, 461 East Asian ancestry cases, 547 East Asian ancestry controls
Affymetrix, Illumina [2442884] (imputed)
683 European ancestry cases, 2,044 European ancestry controls
1,706 European ancestry cases, 10,258 European ancestry controls
1,426 European ancestry cases, 1,301 European ancestry controls
6,031 European ancestry cases, 5,933 European ancestry controls
up to 34,549 European ancestry individuals
up to 16,709 European ancestry individuals
Affymetrix, Illumina [2391896] (imputed)
Serum ceruloplasmin levels
2,050 European ancestry individuals
733 European ancestry cases
139 European ancestry cases, 151 Japanese ancestry cases
Up to 2,706 European ancestry cases
487 Japanese ancestry cases, 476 Japanese ancestry controls
787 Japanese ancestry cases, 615 Japanese ancestry controls
Anthropometric traits in newborns
1,095 Afro-Caribbean individuals, 1,363 European ancestry individuals, 616 Mexican American individuals, 1,207 Thai ancestry individuals
2,296 European ancestry individuals
9,190 European ancestry individuals
2,226 individuals
Dengue shock syndrome
2,008 Vietnamese ancestry child cases, 2,018 Vietnamese ancestry child controls
1,737 Vietnamese ancestry child cases, 2,934 Vietnamese ancestry child controls
125 Japanese ancestry cases, 562 Japanese ancestry controls
1,366 African American individuals, 671 European ancestry individuals
1,190 European and unknown ancestry cases, 401 European and unknown ancestry controls
16,179 individuals
1,169 European ancestry cases, 3,714 European ancestry controls
7,303 European ancestry cases, 26,274 European ancestry controls
833 Japanese ancestry cases, 686 Japanese ancestry controls
411 Japanese ancestry cases, 289 Japanese ancestry controls
763 European ancestry individuals, 1,058 European ancestry individuals
754 European ancestry individuals, 860 European ancestry individuals
26 European ancestry lithium treatment responders, 26 European ancestry lithium treatment non-responders
34 European ancestry lithium treatment responders, 118 European ancestry lithium treatment non-responders
White blood cell types
8,794 Japanese ancestry individuals
5,998 Japanese ancestry individuals
6,707 European ancestry cases, 52,426 European ancestry controls
5,381 European ancestry casses, 10,030 European ancestry controls
3,426 European ancestry cases, 29,624 European ancestry controls
2,127 European ancestry cases, 4,558 European ancestry controls
2,785 European ancestry cases, 2,940 European ancestry controls
Brain connectivity
331 European ancestry individuals
252 European ancestry cases
798 European ancestry cases, 21 African American cases, 10 East Asian ancestry cases, 4 Asian Indian ancestry cases
1,161 Chinese ancestry cases, 1,353 Chinese ancestry controls
4,319 Chinese ancestry cases, 4,966 Chinese ancestry controls
Sex hormone-binding globulin levels
1,598 European ancestry female individuals
1,583 European ancestry female individuals
Testosterone levels
1,589 European ancestry female individuals
1,503 European and other ancestry cases, 1,459 European and other ancestry controls
1,407 cases, 1,418 controls
433 Thai ancestry cases, 295 Thai ancestry controls, 188 Japanese ancestry cases, 934 Japanese ancestry controls
369 Thai ancestry cases, 439 Thai ancestry controls, 112 Japanese ancestry cases, 1,089 Japanese ancestry controls
1,353 European ancestry cases, 3,566 European ancestry controls
12,313 European ancestry cases, Up to 55,667 European ancestry controls
727 European ancestry children, 5,081 European ancestry individuals
1,142 European ancestry individuals, 896 cases and 2,455 controls from 2,064 trios
16,388 African American individuals
4,504 European ancestry individuals
656 European ancestry and African American individuals
832 Chinese ancestry cases, 2,682 Chinese ancestry controls
6,864 European ancestry cases, 12,936 European ancestry controls, 796 Chinese ancestry cases, 978 Chinese ancestry controls
Formal thought disorder in schizophrenia
835 European ancestry cases, 2,694 European ancestry controls
12,389 European ancestry cases, 62,004 European ancestry controls
1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls
2,303 Japanese ancestry cases, 3,380 Japanese ancestry controls
5,604 Japanese ancestry cases, 31,982 Japanese ancestry controls
HbA2 levels
1,716 European ancestry individuals
165 Iranian ancestry early menopause females, 187 Iranian ancestry late menopause females
573 Iranian ancestry females, 38,968 European ancestry females
Attention deficit hyperactivity disorder (combined symptoms)
1,851 individuals
155 individuals
Response to amphetamines
1 American Indian ancestry individual, 18 African American individuals, 10 Asian ancestry individuals, 325 European ancestry individuals, 17 Hispanic individuals, 10 individuals
1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls
1,856 Japanese ancestry cases, 7,021 Japanese ancestry controls
1,409 European ancestry cases, 1,518 European ancestry controls
6,438 European ancestry individuals from 1,645 affected families
1,716 European ancestry cases, 16,888 European ancestry controls
4,035 European ancestry cases, 11,251 European ancestry controls
12,696 European ancestry colorectal tumor cases, 15,113 European ancestry controls
958 European ancestry colorectal tumor cases, 909 European ancestry controls, up to 2,098 East Asian ancestry colorectal tumor cases, up to 5,749 East Asian ancestry controls
Affymetrix, Illumina [2708280] (imputed)
QT interval (drug interaction)
33,781 European ancestry individuals
49,825 European ancestry males, 60,522 European ancestry females
Up to 32,813 European ancestry individuals
Affymetrix, Illumina, Perlegen [2450547] (imputed)
2,115 European ancestry cases, 67,259 European ancestry controls
1,036 European ancestry cases
Affymetrix, Illumina [2538056] (imputed)
435 Turkish uveitis cases, 780 Turkish without uveitis cases, 1,278 Turkish controls
355 Turkish uveitis cases, 483 Turkish without uveitis cases, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls
Estradiol plasma levels (breast cancer)
700 European ancestry cases, 50 African ancestry cases, 17 Asian ancestry cases, 5 American Indian ancestry cases
1,496 East Asian ancestry individuals
Psychosis and Alzheimer's disease
1,039 European ancestry cases with psychosis, 5,659 European ancestry controls, 260 European, African American and Native American ancestry cases with psychosis from 264 families
Psychosis in Alzheimer's disease
1,039 European ancestry cases with psychosis, 610 European ancestry cases without psychosis, 260 European, African American and Native American ancestry cases with psychosis and 125 European, African American and Native American ancestry cases without psychosis from 264 families
Venous thromboembolism (SNP x SNP interaction)
411 European ancestry cases, 1,228 European ancestry controls
1,542 European ancestry cases, 1,110 European ancestry controls
Dental caries
1,483 European ancestry comparatively younger individuals, 5,960 European ancestry comparatively older individuals
Affymetrix, Illumina [~ 1400000] (imputed)
174 European ancestry cases, 823 European ancestry controls
1,012 European ancestry cases, 1,326 European ancestry controls
29,069 European ancestry individuals, 7,557 Indian Asian ancestry individuals
39,576 European ancestry individuals
Response to gemcitabine in pancreatic cancer
21 Japanese ancestry adverse reaction cases, 58 Japanese ancestry non-adverse reaction individuals
33 Japanese ancestry adverse reaction cases, 62 Japanese ancestry non-adverse reaction individuals
156 European ancestry cases from 34 high-risk families, 2,150 European ancestry controls
612 Chinese ancestry cases, 2,193 Chinese ancestry controls
2,866 East Asian ancestry cases, up to 4,808 East Asian ancestry controls, 473 Thai ancestry cases, up to 970 Thai ancestry controls
1,283 European ancestry cases, 1,416 European ancestry controls
1,650 European ancestry cases and 1,684 European ancestry controls from 778 nuclear families
1,230 European ancestry child cases from 1,217 families, 155 African American Asian or Latino child cases from 152 families, 1,880 controls
783 European ancestry child cases from 440 families, 303 child cases from 155 families, 1,965 European, African American and other ancestry controls
4,238 European ancestry cases, 4,239 European ancestry controls
3,738 European ancestry cases, 2,111 European ancestry controls
197 European ancestry cases, 234 European ancestry controls
379 European ancestry cases, 398 European ancestry controls
2,331 Han Chinese ancestry cases, 3,077 Han Chinese ancestry controls
6,313 Han Chinese ancestry cases, 6,409 Han Chinese ancestry controls
813 European ancestry cases, 1,011 European ancestry controls
TENOR and GABRIEL studies
9,136 European ancestry individuals
3,581 European ancestry individuals
6,268 European ancestry individuals
9,244 European ancestry individuals
4,193 European ancestry cases, 35,194 European ancestry controls
6,514 European ancestry cases, 41,455 European ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide)
168 Japanese ancestry cases, 335 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs)
371 Japanese ancestry cases, 825 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel)
218 Japanese ancestry cases, 364 Japanese controls
Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel)
147 Japanese ancestry cases, 233 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors)
106 Japanese ancestry cases, 187 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin)
59 Japanese ancestry cases, 155 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide)
54 Japanese ancestry cases, 39 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin)
261 Japanese ancestry cases, 262 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs)
294 Japanese ancestry cases, 2,249 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin)
150 Japanese ancestry cases, 166 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin)
176 Japanese ancestry cases, 471 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs)
184 Japanese ancestry cases, 459 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin)
83 Japanese ancestry cases, 66 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin)
83 Japanese ancestry cases, 370 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil)
177 Japanese ancestry cases, 952 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs)
428 Japanese ancestry cases, 743 Japanese ancestry controls
Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine)
80 Japanese ancestry cases, 226 Japanese ancestry controls
Cardiovascular heart disease in diabetics
669 European ancestry cases, 1,641 European ancestry controls
848 European ancestry cases, 1,030 European ancestry controls
2,273 Korean ancestry cases, 2,052 Korean ancestry controls
4,049 Korean ancestry cases, 3,845 Korean ancestry controls
437 Chinese ancestry cases, 570 Chinese ancestry controls
329 Hispanic cases, 256 Hispanic controls
5,218 European ancestry individuals
762 European ancestry individuals
Palmitic acid (16:0) levels
8,961 European ancestry individuals
Stearic acid (18:0) levels
Type 2 diabetes (dietary heme iron intake interaction)
1,806 European ancestry cases, 2,965 European ancestry controls
1,178 European ancestry cases, 4,724 European ancestry controls
Sexual dysfunction (SSRI/SNRI-related)
201 Japanese ancestry individuals
972 European ancestry cases, 1,386 European ancestry controls, 89 African American cases, 1,363 African American controls, 305 Hispanic cases, 1,008 Hispanic controls
574 European ancestry cases, 2,601 European ancestry controls, 128 African American cases, 1,075 African American controls, 143 Hispanic cases, 640 Hispanic controls
21 Afro-Caribbean cases, 1,010 Afro-Caribbean controls, 50 European ancestry cases, 1,202 European ancestry controls, 62 Hispanic cases, 658 Hispanic controls
Coronary arterial lesions in patients with Kawasaki disease
64 East Asian ancestry serious cases, 70 East Asian ancestry minor cases
117 East Asian ancestry serious cases, 128 East Asian ancestry minor cases
Cannabis use (initiation)
10,091 individuals from 4,622 families
286 Japanese ancestry cases, 557 Japanese ancestry controls
334 Japanese ancestry cases, 701 Japanese ancestry controls
Response to platinum-based agents
87 European ancestry lymphoblastoid cell lines
52 European ancestry lymphoblastoid cell lines
Age-related macular degeneration (choroidal neovascularisation)
1,775 European ancestry choroidal neovascularization cases, 4,134 European ancestry controls
4,515 European and unknown ancestry choroidal neovascularization cases, 15,240 European and unknown ancestry controls
Affymetrix, Illumina [6036699] (imputed)
Age-related macular degeneration (geographic atrophy)
819 European ancestry geographic atrophy cases, 4,134 European ancestry controls
Age-related macular degeneration (CNV vs. GA)
1,775 European ancestry choroidal neovascularization cases, 819 European ancestry geographic atrophy cases,
4,515 European and unknown ancestry choroidal neovascularization cases, 868 European and unknown ancestry geographic atrophy cases
731 European ancestry cases
7,965 European and East Asian ancestry cases, 8,128 European and East Asian ancestry controls
5,560 European ancestry female individuals, 4,997 European ancestry male individuals
3,891 European ancestry cases, 8,915 European ancestry controls
Affymetrix, Illumina [2391230] (imputed)
5,672 European ancestry individuals
5,878 European ancestry individuals
1,032 European ancestry individuals
9,232 European ancestry individuals
2,318 European ancestry individuals
1,834 European ancestry children, 825 children
11,052 European ancestry individuals
Esophageal cancer (squamous cell)
2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls
8,092 Chinese ancestry cases, 8,620 Chinese ancestry controls
Esophageal cancer (alcohol interaction)
Capecitabine sensitivity
Up to 84 East Asian ancestry lymphoblastoid cell lines, up to 164 European ancestry lymphoblastoid cell lines, up to 173 African ancestry lymphoblastoid cell lines, up to 82 African American lymphoblastoid cell lines
362 African American cases, 2,543 African American controls
862 African American female cases, 7,293 African American female controls
41 Japanese ancestry cases, 866 Japanese ancestry controls
30 Japanese ancestry cases, 898 Japanese ancestry controls
2,023 European ancestry major depressive disorder cases
1,531 European ancestry major depressive disorder cases
Cystic fibrosis (meconium ileus)
3,763 European ancestry cases
2,372 European ancestry cases
Response to bleomycin (chromatid breaks)
673 European ancestry individuals
834 European ancestry individuals
Body mass index (SNP x SNP interaction)
3,653 European ancestry individuals
5,071 European ancestry individuals
Sexual dysfunction (female)
1,104 European ancestry twins
Bone mineral density (wrist)
1,628 Chinese ancestry individuals
Age at smoking initiation in chronic obstructive pulmonary disease
3,397 European ancestry cases
1,907 European ancestry former smoker cases, 1,164 European ancestry current smoker cases
1,113 European ancestry cases
Lifetime average cigarettes per day in chronic obstructive pulmonary disease
3,440 European ancestry cases
180 Korean ancestry cases, 271 Korean ancestry controls
206 Korean ancestry cases, 416 East Asian ancestry controls,
1,083 European ancestry cases, 2,770 European ancestry controls
Up to 1,058 European ancestry cases, 2,254 European ancestry controls
124 Isreali Arab cases, 142 Israeli Arab controls
1,930 European ancestry cases, 1,312 European ancestry controls, 931 European ancestry and Ashkenazi Jewish cases, 1,104 European ancestry and Ashkenazi Jewish controls
132 African American, European, Hispanic/Latin American, East Asian and South Asian ancestry cases, 103 African American, European, Hispanic/Latin American, East Asian ancestry and South Asian ancestry controls
128 African American, European, Hispanic/Latin American, East Asian and South Asian ancestry cases, 102 African American, European, Hispanic/Latin American, East Asian and South Asian ancestry controls
Oral cancers (chewing tobacco related)
55 South Asian ancestry cases, 92 South Asian ancestry controls
65 Singaporean Chinese child cases, 238 Singaporean Chinese child controls, 222 Singaporean Chinese adult cases, 455 Singaporean Chinese adult cases
959 Japanese ancestry cases, 2,128 Japanese ancestry controls
2,198 European ancestry cases, 4,918 European ancestry controls
1,627 European ancestry child cases, 3,254 European ancestry child controls
624 European ancestry child cases, 2,843 European ancestry child controls
Hypertension risk in short sleep duration
4,965 Korean ancestry individuals
Small-cell lung cancer (survival)
305 Han Chinese ancestry cases
Pulmonary function decline
1,441 European ancestry asthma cases, 2,677 European ancestry controls
1,160 European ancestry asthma cases, 10,858 European ancestry controls
1,780 Filipino ancestry females
1,779 Filipino ancestry females
1,792 Filipino ancestry females
715 European ancestry cases, 2,962 European ancestry controls
1,025 European ancestry cases, 2,174 European ancestry controls
690 European ancestry cases, 497 European ancestry controls
2,958 European ancestry cases, 3,727 European ancestry controls
Alcohol withdrawal symptoms
461 European ancestry cases, 408 European ancestry controls
318 European ancestry cases, 507 European ancestry controls
395 European ancestry child cases
584 Hispanic child cases
3,551 Hispanic individuals, 14,767 Japanese ancestry individuals, 19,509 European ancestry individuals
Affymetrix, Illumina [2489215] (imputed)
862 European ancestry male individuals
1,862 European ancestry individuals
15,495 Japanese ancestry females
793 Han Chinese ancestry cases, 806 Han Chinese ancestry controls
4,445 Han Chinese ancestry cases, 4,458 Han Chinese ancestry controls
4,074 Japanese ancestry cases, 16,891 Japanese ancestry controls
5,277 Japanese ancestry cases, 21,684 Japanese ancestry controls
9,849 European ancestry individuals, 894 African ancestry individuals, 271 individuals
Reporting of stressful life event
2,578 European ancestry depression cases and controls
864 European ancestry depression cases, 257 European ancestry controls
Adverse response to carbamazepine
53 Japanese ancestry cases, 881 Japanese ancestry controls
23 Japanese ancestry cases, 44 Japanese ancestry controls
Asthma (bronchodilator response)
1,644 European ancestry cases
1,051 European ancestry cases
Affymetrix, Illumina [4571615] (imputed)
189 Arab-Israeli founder individuals from 57 families
627 European ancestry cases, 541 European ancestry controls
1,695 Japanese ancestry cases, 5,333 Japanese ancestry controls
4,334 Japanese ancestry cases, 8,202 Japanese ancestry controls
927 African American non-diabetic individuals
570 West African ancestry non-diabetic individuals
518 European ancestry controls
459 European ancestry controls
Response to cholinesterase inhibitors in Alzheimer's disease
92 European ancestry cases, 77 European ancestry controls
94 European ancestry cases, 74 European ancestry controls
1,482 chronic HCV cases, 919 spontaneously cleared HCV cases
461 chronic HCV cases, 284 spontaneously cleared HCV cases
1,004 European ancestry individuals
339 European ancestry individuals
Epirubicin-induced leukopenia
67 Japanese ancestry cases, 203 Japanese ancestry controls
48 Japanese ancestry cases
424 European ancestry cases, 1,881 European ancestry controls
C-reactive protein and white blood cell count
8,722 individuals
Retinopathy in non-diabetics
19,411 European ancestry individuals
18,089 African American individuals
2,850 African American individuals, 87,802 European ancestry inidividuals
3,042 individuals
Self-employment
7,734 European ancestry cases, 42,893 European ancestry controls
737 cases, 2,534 controls
951 European ancestry individuals
Comprehensive strength and appendicular lean mass
825 Chinese ancestry female individuals, 802 Chinese ancestry male individuals
1,059 European ancestry male individuals, 2,227 European ancestry female individuals
348 Korean ancestry cases
Aspirin exacerbated respiratory disease in asthmatics
117 Korean ancestry cases, 685 Korean ancestry controls
142 Korean ancestry cases, 996 Korean ancestry controls
1,079 European ancestry cases, 1,341 European ancestry controls
1,419 European ancestry cases, 1,885 European ancestry controls from 778 nuclear families
100 Jewish cases, 397 Jewish controls
59 Jewish cases, 285 Jewish controls, 124 European ancestry cases, 275 European anestry controls, 126 North African ancestry controls, 246 North African ancestry controls
416 cases and 1,075 controls of European and unknown ancestry
1,941 European and unknown ancestry individuals, 142 individuals from 645 families
Thyroid hormone levels
up to 14,459 European ancestry females, up to 10,936 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males
1,726 cases, 1,630 controls
Alzheimer's disease (cognitive decline)
303 European ancestry cases
774 Korean ancestry cases, 967 Korean ancestry controls
482 Korean ancestry children, 468 Korean ancestry pregnant female individuals, 1,242 Korean ancestry female controls
2,317 European ancestry cases, 177 cases
898 European ancestry sibling pair cases, 75 sibling pair cases
Podoconiosis
194 African ancestry cases, 203 African ancestry controls
202 African ancestry family trios
Hypertension (SNP x SNP interaction)
~2,000 European ancestry cases, ~3,000 European ancestry controls
Coronary heart disease (SNP X SNP interaction)
3,986 Han Chinese ancestry cases, 4,157 Han Chinese ancestry controls
13,415 African American individuals
Affymetrix, Illumina [2845108] (imputed)
3,511 European ancestry individuals
670 European ancestry individuals
410 European ancestry long-living individuals, 553 European ancestry young individuals
116 European ancestry long-living individuals, 160 European ancestry young individuals
Fracture-related traits
2,038 indivduals
5,122 European ancestry cases, 18,108 European ancestry controls
3,831 European ancestry cases, 13,889 European ancestry controls
Affymetrix, Illumina [2608509] (imputed)
392 Japanese ancestry cases, 934 Japanese ancestry controls
172 Japanese ancestry cases, 1,012 Japanese ancestry controls
419 Han Chinese ancestry high myopia cases, 669 Han Chinese ancestry controls
2,803 East Asian ancestry high myopia cases, 5,642 East Asian ancestry controls
1,033 Japanese ancestry cases, 1,473 Japanese ancestry controls
1,529 East Asian ancestry cases, 25,675 East Asian ancestry controls, 447 European ancestry cases, 737 European ancestry controls
65 European ancestry cases, 3,987 European ancestry controls
80 European ancestry cases, 257 European ancestry controls
Peripartum cardiomyopathy
36 European ancestry female cases, 703 European ancestry female controls, 5 female cases
59 European ancestry female cases, 303 European ancestry female controls
1,176 cases, 1,101 controls
1,964 European ancestry cases, 3,172 European ancestry controls
515 Chinese ancestry cases, 486 Chinese ancestry controls
2,323 Chinese ancestry cases, 511 Chinese ancestry controls
2,940 European ancestry cases, 1,380 European ancestry controls
502 European ancestry cases, 504 European ancestry controls, 1,110 cases, 2,698 controls
Lean body mass and age at menarche (combined)
801 Han Chinese ancestry female individuals
1,692 European ancestry female individuals
Gambling
1,312 European ancestry twins from 894 families
3,493 European ancestry cases, 13,598 European ancestry controls
3,412 European ancestry cases, 4,928 European ancestry controls
749 European ancestry individuals
1,562 European ancestry individuals, 717 cases
397 European ancestry depressive disorder cases
501 European ancestry depressive disorder cases
Esophageal squamous cell cancer (length of survival)
1,331 Chinese ancestry cases
1,062 Chinese ancestry individuals
Response to anti-depressant treatment in major depressive disorder
1,151 European ancestry cases, 288 African American cases
8,149 African American female individuals
Up to 20,809 African American and African ancestry individuals
2,240 European ancestry individuals
11,024 breast cancer cases, 15,065 controls
1,606 European ancestry cases, 1,794 European ancestry controls
13,195 European ancestry cases, 31,021 European ancestry controls
2,254 Han Chinese ancestry cases, 3,001 Han Chinese ancestry controls
8,226 Han Chinese ancestry cases, 7,578 Han Chinese ancestry controls
84 Korean ancestry cases, 200 Korean ancestry controls
113 Korean ancestry cases, 255 Korean ancestry controls
6,819 European ancestry individuals
7,809 European ancestry indivduals
3,499 European ancestry cases, 1,922 European ancestry controls
983 cases, 1,876 sibling controls
1,034 European ancestry cases, 3,948 European ancestry controls
1,140 European ancestry cases, 1,058 European ancestry controls
22,435 European ancestry female individuals
9,813 individuals
10,052 European ancestry cases, 12,575 European ancestry controls
45,290 European ancestry cases, 41,880 European ancestry controls
17,008 European ancestry cases, 37,154 European ancestry controls
8,572 European ancestry cases, 11,312 European ancestry controls
37,684 European ancestry individuals
10,739 European ancestry individuals
37,382 European ancestry individuals, 3,995 Chinese ancestry individuals, 2,273 Malay ancestry individuals, 2,108 Indian ancestry individuals
706 North Indian ancestry cases, 761 North Indian ancestry controls
927 North Indian ancestry cases, 1,148 North Indian ancestry controls
2,469 African American individuals, 259 Latino individuals, 1,564 European ancestry individuals
2,961 African American individuals, 1,477 Latino individuals, 649 European ancestry individuals, 680 Hutterite individuals
Type 1 diabetes nephropathy
Up to 2,916 European ancestry Type 1 Diabetes cases with nephropathy, 3,315 European ancestry Type 1 Diabetes cases without nephropathy
Up to 1,493 European ancestry Type 1 Diabetes cases with nephropathy, 3,191 European ancestry Type 1 Diabetes cases without nephropathy
6,534 Han Chinese ancestry individuals
1,881 Han Chinese ancestry individuals from 637 families
Odorant perception (isobutyraldehyde)
187 European ancestry individuals
Up to 109 Asian ancestry indiviudals
Odorant perception (β-damascenone)
89 European ancestry individuals
Odorant perception (β-ionone)
Up to 109 Asian ancestry individuals
815 Hispanic children from 263 families
Myasthenia gravis
400 European ancestry cases, 5,505 European ancestry controls
249 European ancestry cases, 3,415 European ancestry controls
Epstein-Barr virus immune response (EBNA-1)
1,367 Mexican American indivduals
589 Mexican American indivduals
Serum protein levels (sST2)
2,797 individuals
Molar-incisor hypomineralization
88 European ancestry cases, 580 European ancestry controls
Platelet reactivity
289 European ancestry type 2 diabetes cases treated with acetylsalicylic acid
9,240 European ancestry cases, 9,519 European ancestry controls
6,783 European ancestry cases, 50,695 European ancestry controls
Affymetrix, Illumina, Perlegen [~ 1200000] (imputed)
Anxiety in major depressive disorder
1,080 European ancestry cases, 442 European ancestry controls
Anxiety and major depressive disorder
1,080 European ancestry cases, 1,588 European ancestry controls
Multiple sclerosis (OCB status)
49 European ancestry OCB negative cases, 513 European ancestry OCB positive cases
200 European ancestry OCB negative cases, 1684 European ancestry OCB positive cases
Thyroid cancer (Papillary, radiation-related)
401 European ancestry cases, 620 European ancestry controls
259 cases, 648 controls
4,006 European ancestry individuals
2,035 European ancestry individuals
Up to 639 European ancestry cases, 6,257 European ancestry controls
Up to 183 European ancestry cases, 961 European ancestry controls
1,618 European ancestry cases, 42,881 European ancestry controls
3,231 European ancestry cases, 3,536 European ancestry controls
Affymetrix, Illumina [2543885] (imputed)
B cell non-Hodgkin lymphoma
253 Singaporean Chinese ancestry cases, 1,438 Singaporean Chinese ancestry controls
1,175 Han Chinese ancestry cases, 5,492 Han Chinese ancestry controls
Alcohol and nicotine co-dependence
818 European ancestry cases, 1,396 European ancestry controls, 449 African American cases, 480 African American controls
Up to 32,961 European and East Asian ancestry individuals
Up to 50,933 European and East Asian ancestry individuals
8,175 European ancestry individuals
1,752 European ancestry individuals
Affymetrix, Illumina [2229753] (imputed)
Body mass index and cholesterol (psychopharmacological treatment)
283 European ancestry schizophrenia cases, 213 European ancestry bipolar disorder cases, 98 European ancestry psychosis cases
2,029 African American individuals, 7,428 European ancestry individuals
1,571 African American individuals, 3,825 European ancestry individuals
Periodontitis (DPAL)
up to 2,501 European ancestry individuals
Affymetrix, Illumina [up to 17585496] (imputed)
Periodontitis (PAL4Q3)
up to 2,969 European ancestry individuals
Periodontitis (Mean PAL)
up to 4,032 European ancestry individuals
Periodontitis (CDC/AAP)
up to 3,915 European ancestry individuals
Response to tocilizumab in rheumatoid arthritis
1,157 European and other ancestry rheumatoid arthritis cases
526 European and other ancestry rheumatoid arthritis cases
2,020 European ancestry neuropsychiatric disorder cases, 5,775 European ancestry controls
599 European ancestry neuropsychiatric disorder cases, 11,915 European ancestry controls, 143 European ancestry and African American neuropsychiatric disorder cases, 94 European ancestry and African American controls, 605 Hispanic controls
2,804 European ancestry cases, 7,618 European ancestry controls
5,551 European ancestry cases, 7,449 European ancestry controls
Lipid levels in hepatitis C treatment
1,017 European ancestry cases, 207 African American cases, 95 Hispanic cases
837 African American individuals
486 West African ancestry individuals
3,736 European ancestry individuals
3,727 European ancestry individuals
Affymetrix, Illumina [2524918] (imputed)
8,506 European ancestry cases, up to 10,596 European ancestry controls
Glutamate decarboxylase autoantibody levels in type 1 diabetes
2,506 European ancestry cases
Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes
2,498 European ancestry cases
3,897 sibling cases
Gastric parietal cell autoantibody levels in type 1 diabetes
4,328 European ancestry cases
Thyroid peroxidase autoantibody levels in type 1 diabetes
8,300 European ancestry cases
1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls
1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases
3,029 European ancestry OCB positive cases, 374 European ancestry OCB negative cases
619 African American individuals
5,272 European ancestry indiviudals
40,407 European ancestry individuals
941 European ancestry cases and 404 European ancestry controls from 410 families
1,767 European ancestry cases and 838 European ancestry controls from 875 families
1,738 European ancestry cases, 1,802 European ancestry controls
6,079 European ancestry cases, 5,893 European ancestry controls
Response to antineoplastic agents
356 European ancestry cases
1,880 European ancestry individuals
3,468 Hispanic female individuals
506 Han Chinese ancestry cases, 1,859 Han Chinese ancestry controls
706 Han Chinese ancestry cases, 1,777 Han Chinese ancestry controls
899 European ancestry cases, 804 European ancestry controls
1,264 European ancestry cases, 1,222 European ancestry controls
1,167 European ancestry cases, 777 European ancestry controls
1,855 European ancestry cases, 3,091 European ancestry controls
547 European ancestry cases, 928 European ancestry controls
1,266 European ancestry cases, 559 European ancestry controls, Up to 428 European ancestry trios
733 Japanese ancestry cases, 729 Japanese ancestry controls
2,794 Japanese ancestry drinkers, 1,521 Japanese ancestry chance drinkers, 1,351 Japanese ancestry non-drinkers
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)
6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls
2,346 Micronesian ancestry individuals
10,112 Japanese ancestry individuals
2,742 Japanese ancestry individuals
Response to angiotensin II receptor blocker therapy
198 European ancestry hypertensive individuals, 193 African American hypertensive individuals
Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy)
394 European ancestry hypertensive individuals, 193 African American hypertensive individuals
684 European ancestry cases, 188 European ancestry controls
1,896 European ancestry cases, 1,866 European ancestry controls
Nephropathy
1,194 Han Chinese ancestry cases, 902 Han Chinese ancestry controls
712 Han Chinese ancestry cases, 748 Han Chinese ancestry controls, 1,238 European ancestry cases, 1,172 European ancestry controls
Renal transplant outcome
Response to antidepressants
92 Japanese ancestry cases
136 Japanese ancestry cases
Economic and political preferences
9,617 European ancestry individuals
Economic and political preferences (environmentalism)
Economic and political preferences (fairness)
Economic and political preferences (feminism/equality)
Economic and political preferences (immigration/crime)
Economic and political preferences (time)
Crohn's disease and celiac disease
3,230 European ancestry Crohn's disease cases, 768 European ancestry celiac disease cases, 6,251 European ancestry controls
1,835 European ancestry Crohn's disease cases, 3,149 European ancestry celiac disease cases, 6,383 European ancestry controls
16,247 European ancestry cases, 346,486 European ancestry controls, 52,942 cases, 355,713 controls
Fulminant type 1 diabetes
257 Japanese ancestry cases, 419 Japanese ancestry controls
Poor prognosis in Crohn's disease
243 Korean ancestry poor prognosis cases, 364 Korean ancestry good prognosis controls
145 Korean ancestry poor prognosis cases, 129 Korean ancestry good prognosis controls
360 Japanese ancestry cases, 11,049 Japanese ancestry controls
4,222 Han Chinese ancestry cases, 8,431 Han Chinese ancestry controls
4,576 European ancestry cases, 8,039 European ancestry controls
4,222 Han Chinese ancestry cases, 8,431 Han Chinese ancestry controls, 4,576 European ancestry cases, 8,039 European ancestry controls
Low hand grip strength (60 years and older) (EWGSOP)
48,596 European ancestry cases, 207,927 European ancestry controls
Affymetrix, Illumina [9457422] (imputed)
34,589 European ancestry female cases, 100,879 European ancestry female controls
Affymetrix, Illumina [9449805] (imputed)
14,007 European ancestry male cases, 107,048 European ancestry male controls
Affymetrix, Illumina [9464541] (imputed)
Low hand grip strength (60 years and older) (FNIH)
20,335 European ancestry cases, 236,188 European ancestry controls
Affymetrix, Illumina [9465622] (imputed)
13,601 European ancestry female cases, 121,867 European ancestry female controls
Affymetrix, Illumina [9431325] (imputed)
6,734 European ancestry male cases, 114,321 European ancestry male controls
Affymetrix, Illumina [9471905] (imputed)
10,668 Chinese ancestry cases, 10,679 Chinese ancestry controls
14,361 European ancestry cases, 43,923 European ancestry controls, 8,267 East Asian ancestry cases, 244,741 East Asian ancestry controls
Rotator cuff injury
6,993 European ancestry cases, 669 Latin American cases, 394 East Asian ancestry cases, 269 African American cases, 32 South Asian ancestry cases, 76,271 European ancestry controls, 7,891 Latin American controls, 7,124 East Asian ancestry controls, 2,892 African American controls, 444 South Asian ancestry controls
Facial morphology (segment 51)
3,566 European ancestry individuals
4,680 European ancestry individuals
Facial morphology (segment 52)
Facial morphology (segment 15)
Facial morphology (segment 16)
Facial morphology (segment 55)
Facial morphology (segment 18)
Facial morphology (segment 19)
Facial morphology (segment 20)
Facial morphology (segment 21)
Facial morphology (segment 22)
Facial morphology (segment 60)
Facial morphology (segment 61)
Facial morphology (segment 26)
Facial morphology (segment 63)
Facial morphology (segment 28)
Facial morphology (segment 2)
Facial morphology (segment 30)
Facial morphology (segment 4)
3,566 European ancestry individuals, 4,680 European ancestry individuals
Facial morphology (segment 32)
Facial morphology (segment 6)
Facial morphology (segment 34)
Facial morphology (segment 8)
Facial morphology (segment 9)
Facial morphology (segment 10)
Facial morphology (segment 11)
Facial morphology (segment 12)
Facial morphology (segment 13)
Facial morphology (segment 14)
Facial morphology (segment 53)
Facial morphology (segment 54)
Facial morphology (segment 17)
Facial morphology (segment 56)
Facial morphology (segment 57)
Facial morphology (segment 58)
Facial morphology (segment 59)
Facial morphology (segment 23)
Facial morphology (segment 24)
Facial morphology (segment 25)
Facial morphology (segment 62)
Facial morphology (segment 27)
Facial morphology (segment 1)
Facial morphology (segment 29)
Facial morphology (segment 3)
Facial morphology (segment 31)
Facial morphology (segment 5)
Facial morphology (segment 33)
Facial morphology (segment 7)
Facial morphology (segment 35)
Facial morphology (segment 36)
Facial morphology (segment 37)
4,680 European ancestry individuals, 3,566 European ancestry individuals
Facial morphology (segment 39)
Facial morphology (segment 44)
Facial morphology (segment 46)
Facial morphology (segment 47)
Facial morphology (segment 48)
Facial morphology (segment 49)
Facial morphology (segment 50)
Facial morphology (segment 38)
Facial morphology (segment 40)
Facial morphology (segment 41)
Facial morphology (segment 42)
Facial morphology (segment 43)
Facial morphology (segment 45)
Forns index in high alcohol intake
33,437 British ancestry individuals
Aspartate aminotransferase platelet ratio index in high alcohol intake
33,330 British ancestry individuals
Fibrosis-4 index in high alcohol intake
33,324 British ancestry individuals
Aspartate transaminase levels in high alcohol intake
34,101 British ancestry individuals
Alanine transaminase levels in high alcohol intake
34,238 British ancestry individuals
Bell's palsy
4,714 European ancestry cases, 1,011,520 European ancestry controls
Affymetrix, Illumina [30341632] (imputed)
180,726 European ancestry men
Sex hormone-binding globulin levels adjusted for BMI
368,929 European ancestry individuals
370,125 European ancestry individuals
Total testosterone levels
230,454 European ancestry women
194,453 European ancestry men
425,097 European ancestry individuals
Bioavailable testosterone levels
188,507 European ancestry women
178,782 European ancestry men
382,988 European ancestry individuals
206,927 European ancestry men
188,908 European ancestry women
189,473 European ancestry women
180,094 European ancestry men
21,758 European ancestry individuals
9,173 individuals
Affymetrix, Illumina [20300000] (imputed)
Adrenomedullin levels
Proto-oncogene tyrosine-protein kinase Src levels
TNF-related apoptosis-inducing ligand levels
Macrophage colony-stimulating factor 1 levels
Atrial fibrillation (chronic vs. intermittent)
340 German ancestry individuals
2,798 German ancestry individuals
2,824 German ancestry individuals
2,821 German ancestry individuals
Cardiomyopathy
Arterial hypertension (history of)
Treatment with insulin
2,811 German ancestry individuals
Peripheral vascular disease
2,789 German ancestry individuals
Valve disease
Venous thrombosis or pulmonary embolism
2,817 German ancestry individuals
Saturated fatty acid levels (palmitic acid C16:0)
2,776 German ancestry individuals
Saturated fatty acid levels (stearic acid C18:0)
Polyunsaturated omega-3 fatty acid levels (DHA C22:6n3)
Saturated fatty acid levels (myristic acid C14:0)
Exogenous monosaturated fatty acid levels (trans-palmitoleic acid C16:1n7t)
Monounsaturated omega-9 fatty acid levels (oleic acid C18:1n9)
Trans-fatty acid levels (9-trans 12-trans octadecanoic acid, linolelaidic acid C18:2n6tt)
Trans-fatty acid levels (9-cis 12-trans octadecanoic acid C18:2n6ct)
Trans-fatty acid levels (9-trans 12-cis octadecanoic acid C18:2n6tc)
Polyunsaturated omega-6 fatty acid levels (linoleic acid C18:2n6)
Polyunsaturated omega-3 fatty acid levels (linolenic acid C18:3n3)
Polyunsaturated omega-6 fatty acid levels (Arachidonic acid C20:4n6)
29,902 European ancestry individuals
P3 amplitude reduction
4,166 European ancestry individuals
P3 genetic factor
3,088 European ancestry individuals
Antisaccade tracking error rate
4,469 European ancestry individuals
Skin conductance level
3,791 European ancestry individuals
Electrodermal activity factor
4,424 European ancestry individuals
Overall startle response
3,323 European ancestry individuals
Aversive difference startle modulation
3,321 European ancestry individuals
Pleasant difference startle modulation
3,322 European ancestry individuals
Skin conductance response frequency
4,299 European ancestry individuals
Skin conductance response amplitude
4,102 European ancestry individuals
Alpha electroencephalogram power
3,948 European ancestry individuals
Beta electroencephalogram power
Theta electroencephalogram power
Delta electroencephalogram power
Total electroencephalogram power
Alpha electroencephalogram power O1O2
Alpha electroencephalogram frequency O1O2
Polyunsaturated omega-6 fatty acid levels (dihomo-g-linolenic acid C20:3n6)
Polyunsaturated omega-3 fatty acid levels (EPA C20:5n3)
3,301 European ancestry individuals
12,207 Hispanic/Latino individuals
8,224 African American individuals, 3,549 Hispanic individuals
11,688 Hispanic/Latino individuals
799 cases, 1,529 controls
Exome genotyping array [Exome array, Agena MassArray]
Lectin-like oxidized LDL receptor 1 levels
Prolactin levels
Matrix metalloproteinase-1 levels
Kidney injury molecule 1 levels
Membrane-bound aminopeptidase P levels
39,620 European ancestry individuals
Affymetrix, Illumina [8227808] (imputed)
Age-related nuclear cataracts
7,352 European ancestry individuals, 2,230 Chinese ancestry individuals, 2,369 Malay ancestry individuals, 2,200 Indian ancestry individuals
941 European ancestry cases, 922 European ancestry controls, 769 Chinese ancestry cases, 759 Chinese ancestry controls, 1,097 indian ancestry cases, 811 indian ancestry controls
Early onset atrial fibrillation
2,781 European ancestry cases, 4,959 European ancestry controls
3,200 European ancestry individuals
22,775 East Asian ancestry cases, 47,731 East Asian ancestry controls
Affymetrix, Illumina [up to 10700000] (imputed)
Fragile X syndrome
80 European ancestry male cases, 9 male cases, 266 European ancestry male controls
CD127 on granulocyte
2,920 Sardinians individuals
CD127 on CD8+ T cell
CD127 on CD28+ CD45RA- CD8+ T cell
CD127 on CD28+ CD45RA+ CD8+ T cell
CD127 on CD28- CD8+ T cell
CD127 on CD4+ T cell
CD127 on CD45RA+ CD4+ T cell
CD25 on CD45RA- CD4 not regulatory T cell
3,435 Sardinians individuals
CD25 on CD45RA+ CD4 not regulatory T cell
CD25 on CD39+ CD4 regulatory T cell
3,434 Sardinians individuals
CD25 on CD4 regulatory T cell
CD25 on resting CD4 regulatory T cell
CD25 on CD39+ resting CD4 regulatory T cell
3,118 Sardinians individuals
CD25 on activated CD4 regulatory T cell
CD25 on CD39+ activated CD4 regulatory T cell
CD25 on secreting CD4 regulatory T cell
CD25 on CD39+ secreting CD4 regulatory T cell
CD25 on activated & secreting CD4 regulatory T cell
CD123 on plasmacytoid Dendritic Cell
2,872 Sardinians individuals
CD123 on CD62L+ plasmacytoid Dendritic Cell
CD33 on CD14+ monocyte
1,634 Sardinians individuals
CD33 on CD33+ HLA DR+ CD14dim
1,577 Sardinians individuals
CD33 on CD33dim HLA DR+ CD11b+
1,633 Sardinians individuals
CD33 on CD33dim HLA DR+ CD11b-
CD33 on Granulocytic Myeloid-Derived Suppressor Cells
1,244 Sardinians individuals
CD33 on CD66b++ myeloid cell
1,464 Sardinians individuals
CD33 on Monocytic Myeloid-Derived Suppressor Cells
1,569 Sardinians individuals
CD33 on CD33dim HLA DR-
1,558 Sardinians individuals
CD33 on basophil
1,555 Sardinians individuals
CD33 on Immature Myeloid-Derived Suppressor Cells
1,554 Sardinians individuals
CD33 on CD33+ HLA DR+
1,579 Sardinians individuals
CD33 on CD33+ HLA DR+ CD14-
1,578 Sardinians individuals
CD4 on monocyte
3,112 Sardinians individuals
CD4 on HLA DR+ CD4+ T cell
3,060 Sardinians individuals
CD25 on CD4+ T cell
CD25 on CD39+ CD4+ T cell
CD25 on CD28+ CD4+ T cell
FSC-A on myeloid Dendritic Cell
FSC-A on plasmacytoid Dendritic Cell
FSC-A on monocyte
2,850 Sardinians individuals
FSC-A on granulocyte
FSC-A on CD14+ monocyte
FSC-A on B cell
FSC-A on Natural Killer
3,113 Sardinians individuals
FSC-A on HLA DR+ Natural Killer
2,971 Sardinians individuals
FSC-A on lymphocyte
FSC-A on T cell
FSC-A on CD4+ T cell
FSC-A on CD8+ T cell
FSC-A on HLA DR+ T cell
HVEM on Central Memory CD4+ T cell
1,247 Sardinians individuals
HVEM on naive CD4+ T cell
HVEM on Effector Memory CD4+ T cell
HVEM on Terminally Differentiated CD4+ T cell
1,245 Sardinians individuals
HVEM on CD45RA- CD4+ T cell
HVEM on CD8+ T cell
HVEM on Central Memory CD8+ T cell
CD16-CD56 on Natural Killer T
CD16-CD56 on Natural Killer
CD16-CD56 on HLA DR+ Natural Killer
CD28 on CD39+ activated CD4 regulatory T cell
CD28 on secreting CD4 regulatory T cell
CD28 on CD39+ secreting CD4 regulatory T cell
CD28 on activated & secreting CD4 regulatory T cell
CD28 on CD45RA+ CD4+ T cell
CD28 on CD45RA- CD4 not regulatory T cell
CD28 on CD39+ CD4+ T cell
CD28 on CD28+ CD45RA- CD8+ T cell
CD28 on CD28+ CD4+ T cell
CD28 on CD28+ CD4-CD8- T cell
2,919 Sardinians individuals
CD28 on CD28+ CD45RA+ CD8+ T cell
CD28 on CD39+ CD8+ T cell
2,914 Sardinians individuals
CD28 on CD4+ T cell
CD28 on CD4 regulatory T cell
CD28 on resting CD4 regulatory T cell
CD28 on CD39+ resting CD4 regulatory T cell
2,650 Sardinians individuals
CD28 on activated CD4 regulatory T cell
CD86 on myeloid Dendritic Cell
2,871 Sardinians individuals
CD86 on CD62L+ myeloid Dendritic Cell
CD86 on monocyte
CD86 on granulocyte
2,848 Sardinians individuals
CCR7 on naive CD4+ T cell
2,910 Sardinians individuals
CCR7 on naive CD8+ T cell
CD45 on CD14+ monocyte
CD45 on B cell
CD45 on Natural Killer
CD45 on HLA DR+ Natural Killer
CD45 on granulocyte
CD45 on lymphocyte
CD45 on T cell
CD45 on CD4+ T cell
CD45 on CD8+ T cell
CD45 on HLA DR+ T cell
CD45 on Natural Killer T
CD45 on HLA DR+ CD4+ T cell
CD45 on HLA DR+ CD8+ T cell
CD127 on T cell
CD127 on CD45RA- CD4 not regulatory T cell
CD127 on CD28+ CD4+ T cell
CD127 on CD28+ CD4-CD8- T cell
2,918 Sardinians individuals
7,495 European ancestry cases, 71,934 European ancestry controls
Affymetrix, Illumina [4471083] (imputed)
7,495 European ancestry cases, 3,259 East Asian ancestry cases, 71,934 European ancestry controls, 234,948 East Asian ancestry controls
Affymetrix, Illumina [3527309] (imputed)
CD64 on CD14- CD16-
3,622 Sardinians individuals
PDL-1 on monocyte
3,629 Sardinians individuals
FSC-A on Natural Killer T
FSC-A on HLA DR+ CD4+ T cell
FSC-A on HLA DR+ CD8+ T cell
CD16 on CD14- CD16+ monocyte
3,620 Sardinians individuals
CCR2 on CD14+ CD16- monocyte
CD16 on CD14+ CD16+ monocyte
3,617 Sardinians individuals
CCR2 on CD14- CD16+ monocyte
3,621 Sardinians individuals
CD14 on CD14+ CD16+ monocyte
3,618 Sardinians individuals
HLA DR on CD14- CD16+ monocyte
CD40 on monocytes
CD14 on CD14+ CD16- monocyte
CD64 on CD14+ CD16- monocyte
HLA DR on CD14+ CD16- monocyte
CD40 on CD14- CD16+ monocyte
CD64 on CD14- CD16+ monocyte
3,614 Sardinians individuals
HLA DR on CD14+ monocyte
CCR2 on monocyte
PDL-1 on CD14+ CD16- monocyte
CD14 on Monocytic Myeloid-Derived Suppressor Cells
1,570 Sardinians individuals
CX3CR1 on monocyte
3,590 Sardinians individuals
CD14 on CD33dim HLA DR+ CD11b+
CD4 on CD4+ T cell
2,912 Sardinians individuals
CD4 on Central Memory CD4+ T cell
CD4 on naive CD4+ T cell
CCR2 on CD14- CD16-
CD40 on CD14+ CD16- monocyte
CD40 on CD14+ CD16+ monocyte
CD64 on monocyte
HLA DR on CD14+ CD16+ monocyte
HLA DR on CD14- CD16-
HLA DR on monocyte
CD64 on CD14+ CD16+ monocyte
3,611 Sardinians individuals
CX3CR1 on CD14- CD16+ monocyte
3,582 Sardinians individuals
CCR2 on myeloid Dendritic Cell
2,870 Sardinians individuals
CCR2 on CD62L+ myeloid Dendritic Cell
CCR2 on plasmacytoid Dendritic Cell
CCR2 on CD62L+ plasmacytoid Dendritic Cell
CCR2 on CD14+ CD16+ monocyte
CCR2 on granulocyte
CX3CR1 on CD14- CD16-
CD14 on CD33+ HLA DR+ CD14dim
CX3CR1 on CD14+ CD16+ monocyte
3,579 Sardinians individuals
CX3CR1 on CD14+ CD16- monocyte
PDL-1 on CD14+ CD16+ monocyte
PDL-1 on CD14- CD16+ monocyte
PDL-1 on CD14- CD16-
CD4 on Effector Memory CD4+ T cell
1,137 Ethiopian ancestry cases, 1,152 Ethiopian ancestry controls
Sick sinus syndrome
6,189 European ancestry cases, 931,046 European ancestry controls
280 Norwegian ancestry cases, 69,141 Norwegian ancestry controls
CD4 on Terminally Differentiated CD4+ T cell
2,903 Sardinians individuals
CD4 on CD45RA+ CD4+ T cell
2,911 Sardinians individuals
CD19 on B cell
CD39 on CD39+ CD8+ T cell
2,915 Sardinians individuals
CD39 on CD39+ activated CD4 regulatory T cell
CD39 on CD39+ secreting CD4 regulatory T cell
297 East Asian ancestry male cases, 153 East Asian ancestry female cases, 539 East Asian ancestry male controls, 595 East Asian ancestry female controls
533 East Asian ancestry male cases, 270 East Asian ancestry female cases, 1,648 East Asian ancestry male controls, 2,045 East Asian ancestry female controls
Tuberculosis susceptibility in HIV infection
267 Sub-Saharan African cases, 314 Sub-Saharan African controls
Age-related hearing impairment (MTAG)
330,759 European ancestry individuals
Beta 1 electroencephalogram power
Beta 2 electroencephalogram power
up to 341,427 European ancestry individuals
up to 377,334 European ancestry individuals
up to 547,219 European ancestry individuals
up to 1,232,091 European ancestry individuals
up to 941,280 European ancestry individuals
Age of smoking initiation (MTAG)
up to 931,815 European ancestry individuals
CD4 regulatory T cell %CD4+ T cell
3,437 Sardinians individuals
CD4 regulatory T cell %T cell
Resting CD4 regulatory T cell Absolute Count
3,405 Sardinians individuals
Resting CD4 regulatory T cell %CD4 regulatory T cell
Resting CD4 regulatory T cell %CD4+ T cell
CD39+ resting CD4 regulatory T cell Absolute Count
CD39+ resting CD4 regulatory T cell %resting CD4 regulatory T cell
CD39+ resting CD4 regulatory T cell %CD4 regulatory T cell
Activated CD4 regulatory T cell Absolute Count
Smoking cessation (MTAG)
up to 820,192 European ancestry individuals
CD39+ secreting CD4 regulatory T cell Absolute Count
CD39+ secreting CD4 regulatory T cell %secreting CD4 regulatory T cell
CD39+ secreting CD4 regulatory T cell %CD4 regulatory T cell
Activated & resting CD4 regulatory T cell Absolute Count
Activated & resting CD4 regulatory T cell %CD4 regulatory T cell
Activated & resting CD4 regulatory T cell %CD4+ T cell
Smoking initiation (ever regular vs never regular) (MTAG)
up to 1,359,002 European ancestry individuals
up to 1,039,210 European ancestry individuals
HLA DR++ monocyte %leukocyte
3,595 Sardinians individuals
HLA DR++ monocyte Absolute Count
Cigarettes smoked per day (MTAG)
up to 403,928 European ancestry individuals
Activated CD4 regulatory T cell %CD4 regulatory T cell
Activated CD4 regulatory T cell %CD4+ T cell
CD39+ activated CD4 regulatory T cell Absolute Count
CD39+ activated CD4 regulatory T cell %activated CD4 regulatory T cell
CD39+ activated CD4 regulatory T cell %CD4 regulatory T cell
Secreting CD4 regulatory T cell Absolute Count
Secreting CD4 regulatory T cell %CD4 regulatory T cell
Secreting CD4 regulatory T cell %CD4+ T cell
CD33dim HLA DR+ CD11b+ %CD33dim HLA DR+
1,858 Sardinians individuals
Activated & secreting CD4 regulatory T cell %CD4 regulatory T cell
CD33dim HLA DR+ CD11b- %CD33dim HLA DR+
CD25++ CD4+ T cell Absolute Count
Monocytic Myeloid-Derived Suppressor Cells Absolute Count
1,855 Sardinians individuals
CD33dim HLA DR- Absolute Count
1,856 Sardinians individuals
Basophil Absolute Count
1,857 Sardinians individuals
Basophil %CD33dim HLA DR- CD66b-
CD45RA- CD4+ T cell Absolute Count
3,395 Sardinians individuals
CD25++ CD45RA- CD4 not regulatory T cell %CD4+ T cell
CD45RA- CD4+ T cell %T cell
3,427 Sardinians individuals
CD4 regulatory T cell Absolute Count
Hematopoietic Stem Cell Absolute Count
Immature Myeloid-Derived Suppressor Cells Absolute Count
Immature Myeloid-Derived Suppressor Cells %CD33dim HLA DR- CD66b-
Naive CD4+ T cell %CD4+ T cell
CD33+ HLA DR+ CD14- Absolute Count
CD33+ HLA DR+ CD14- %CD33+ HLA DR+
Effector Memory CD4+ T cell %T cell
CD33+ HLA DR+ CD14dim %CD33+ HLA DR+
CD33- HLA DR- Absolute Count
Terminally Differentiated CD4+ T cell %T cell
Granulocytic Myeloid-Derived Suppressor Cells Absolute Count
Central Memory CD8+ T cell %CD8+ T cell
Central Memory CD8+ T cell %T cell
Activated & secreting CD4 regulatory T cell Absolute Count
CD33dim HLA DR+ CD11b- Absolute Count
Activated & secreting CD4 regulatory T cell %CD4+ T cell
CD66b++ myeloid cell Absolute Count
CD25++ CD4+ T cell %CD4+ T cell
CD25++ CD4+ T cell %T cell
CD25++ CD45RA+ CD4 not regulatory T cell Absolute Count
CD25++ CD45RA+ CD4 not regulatory T cell %CD4+ T cell
CD25++ CD45RA+ CD4 not regulatory T cell %T cell
CD25++ CD45RA- CD4 not regulatory T cell Absolute Count
CD45RA- CD4+ T cell %CD4+ T cell
CD25++ CD45RA- CD4 not regulatory T cell %T cell
Central Memory CD4+ T cell Absolute Count
Central Memory CD4+ T cell %CD4+ T cell
Central Memory CD4+ T cell %T cell
Naive CD4+ T cell Absolute Count
CD33+ HLA DR+ Absolute Count
Effector Memory CD4+ T cell Absolute Count
Effector Memory CD4+ T cell %CD4+ T cell
CD33+ HLA DR+ CD14dim Absolute Count
Terminally Differentiated CD4+ T cell Absolute Count
Terminally Differentiated CD4+ T cell %CD4+ T cell
CD33- HLA DR+ Absolute Count
Central Memory CD8+ T cell Absolute Count
CD33dim HLA DR+ CD11b+ Absolute Count
CD62L- monocyte %monocyte
3,042 Sardinians individuals
CD11c+ CD62L- monocyte Absolute Count
3,017 Sardinians individuals
CD11c+ CD62L- monocyte %monocyte
3,040 Sardinians individuals
CD62L- HLA DR++ monocyte Absolute Count
3,018 Sardinians individuals
CD62L- HLA DR++ monocyte %monocyte
3,041 Sardinians individuals
CD11c+ HLA DR++ monocyte Absolute Count
3,019 Sardinians individuals
CD11c+ HLA DR++ monocyte %monocyte
Myeloid Dendritic Cell Absolute Count
3,387 Sardinians individuals
Myeloid Dendritic Cell %Dendritic Cell
3,410 Sardinians individuals
Plasmacytoid Dendritic Cell Absolute Count
3,374 Sardinians individuals
Dendritic Cell Absolute Count
CD62L- Dendritic Cell Absolute Count
CD62L- Dendritic Cell %Dendritic Cell
CD86+ myeloid Dendritic Cell Absolute Count
CD86+ myeloid Dendritic Cell %Dendritic Cell
CD86+ plasmacytoid Dendritic Cell Absolute Count
CD86+ plasmacytoid Dendritic Cell %Dendritic Cell
CD62L- myeloid Dendritic Cell Absolute Count
CD62L- myeloid Dendritic Cell %Dendritic Cell
CD62L- plasmacytoid Dendritic Cell Absolute Count
CD62L- plasmacytoid Dendritic Cell %Dendritic Cell
CD62L- CD86+ myeloid Dendritic Cell Absolute Count
CD62L- CD86+ myeloid Dendritic Cell %Dendritic Cell
Plasmacytoid Dendritic Cell %Dendritic Cell
HLA DR++ monocyte %monocyte
Metamizole-induced agranulocytosis or neutropenia
45 European ancestry cases, 191 European ancestry controls
41 European ancestry cases, 273 European ancestry controls
Metamizole-induced agranulocytosis
30 European ancestry cases, 191 European ancestry controls
160 African ancestry cases, 584 Asian ancestry cases, 1,068 Caucasian ancestry cases, 37 Native American ancestry cases, 849 admixed ancestry cases, 5 cases, 219 African ancestry controls, 1,433 Asian ancestry controls, 3,563 Caucasian ancestry controls, 152 Native American ancestry controls, 2,420 admixed ancestry controls, 52 controls
Adherence to a Japanese dietary pattern
14,079 Japanese ancestry individuals
Type 2 diabetes or prostate cancer (pleiotropy)
62,892 European ancestry T2D cases, 79,194 European ancestry PrCa cases, 659,536 European ancestry controls
195 Japanese ancestry cases, 1,553 Japanese ancestry controls
753 Japanese ancestry cases, 1,358 Japanese ancestry controls
Hepatic lipid content
244 Asian Indian individuals
454,183 European ancestry individuals
Noncognitive aspects of educational attainment
510,795 European ancestry individuals
Affymetrix, Illumina, Perlegen [7305956] (imputed)
Cognitive aspects of educational attainment
257,700 European ancestry individuals
Octadecanoylcarnitine levels
30,138 Caucasian ancestry individuals
Affymetrix, Illumina [6039747] (imputed)
Octadecenoylcarnitine levels
15,967 Caucasian ancestry individuals
Affymetrix, Illumina [6084364] (imputed)
Octadecandienylcarnitine levels
31,129 Caucasian ancestry individuals
Affymetrix, Illumina [6058871] (imputed)
lysoPhosphatidylcholine acyl C14:0 levels
9,363 Caucasian ancestry individuals
Affymetrix, Illumina [6083623] (imputed)
lysoPhosphatidylcholine acyl C16:1 levels
16,836 Caucasian ancestry individuals
Affymetrix, Illumina [5791495] (imputed)
lysoPhosphatidylcholine acyl C17:0 levels
16,839 Caucasian ancestry individuals
Affymetrix, Illumina [5791690] (imputed)
lysoPhosphatidylcholine acyl C18:0 levels
Affymetrix, Illumina [5792004] (imputed)
lysoPhosphatidylcholine acyl C18:2 levels
16,837 Caucasian ancestry individuals
Affymetrix, Illumina [5791071] (imputed)
lysoPhosphatidylcholine acyl C20:4 levels
16,838 Caucasian ancestry individuals
Affymetrix, Illumina [5791771] (imputed)
lysoPhosphatidylcholine acyl C26:1 levels
Affymetrix, Illumina [6083819] (imputed)
lysoPhosphatidylcholine acyl C16:0 levels
Affymetrix, Illumina [5792440] (imputed)
lysoPhosphatidylcholine acyl C18:1 levels
Affymetrix, Illumina [5791467] (imputed)
lysoPhosphatidylcholine acyl C20:3 levels
Affymetrix, Illumina [5792163] (imputed)
lysoPhosphatidylcholine acyl C24:0 levels
Affymetrix, Illumina [6083871] (imputed)
lysoPhosphatidylcholine acyl C26:0 levels
Affymetrix, Illumina [6083737] (imputed)
lysoPhosphatidylcholine acyl C28:0 levels
15,963 Caucasian ancestry individuals
Affymetrix, Illumina [6084421] (imputed)
lysoPhosphatidylcholine acyl C28:1 levels
Affymetrix, Illumina [5792091] (imputed)
Phosphatidylcholine diacyl C24:0 levels
13,184 Caucasian ancestry individuals
Affymetrix, Illumina [6083416] (imputed)
Phosphatidylcholine diacyl C26:0 levels
Affymetrix, Illumina [6083682] (imputed)
Affymetrix, Illumina [5791678] (imputed)
Phosphatidylcholine diacyl C30:0 levels
Affymetrix, Illumina [5791235] (imputed)
Phosphatidylcholine diacyl C32:0 levels
Affymetrix, Illumina [5791755] (imputed)
Phosphatidylcholine diacyl C32:1 levels
Affymetrix, Illumina [5790467] (imputed)
Phosphatidylcholine diacyl C32:2 levels
Affymetrix, Illumina [5789893] (imputed)
Phosphatidylcholine diacyl C34:1 levels
Affymetrix, Illumina [5791930] (imputed)
Phosphatidylcholine diacyl C34:2 levels
Affymetrix, Illumina [5792223] (imputed)
Phosphatidylcholine diacyl C34:3 levels
Affymetrix, Illumina [5791551] (imputed)
Phosphatidylcholine diacyl C34:4 levels
Affymetrix, Illumina [5790991] (imputed)
Phosphatidylcholine diacyl C36:0 levels
Affymetrix, Illumina [5791651] (imputed)
Phosphatidylcholine diacyl C36:2 levels
Affymetrix, Illumina [5792013] (imputed)
Phosphatidylcholine diacyl C36:3 levels
Affymetrix, Illumina [5791858] (imputed)
Phosphatidylcholine diacyl C36:4 levels
Affymetrix, Illumina [5791936] (imputed)
Phosphatidylcholine diacyl C36:5 levels
16,835 Caucasian ancestry individuals
Affymetrix, Illumina [5790837] (imputed)
Phosphatidylcholine diacyl C36:6 levels
Affymetrix, Illumina [5791314] (imputed)
Phosphatidylcholine diacyl C38:0 levels
Affymetrix, Illumina [5791519] (imputed)
Phosphatidylcholine diacyl C38:3 levels
Affymetrix, Illumina [5791226] (imputed)
Phosphatidylcholine diacyl C38:4 levels
Affymetrix, Illumina [5791386] (imputed)
Phosphatidylcholine diacyl C38:5 levels
Affymetrix, Illumina [5791436] (imputed)
Phosphatidylcholine diacyl C38:6 levels
Affymetrix, Illumina [5791244] (imputed)
Phosphatidylcholine diacyl C40:2 levels
16,719 Caucasian ancestry individuals
Affymetrix, Illumina [5793499] (imputed)
Phosphatidylcholine diacyl C40:3 levels
16,431 Caucasian ancestry individuals
Affymetrix, Illumina [5793014] (imputed)
Phosphatidylcholine diacyl C40:4 levels
Affymetrix, Illumina [5791955] (imputed)
Phosphatidylcholine diacyl C40:5 levels
Affymetrix, Illumina [5791407] (imputed)
Phosphatidylcholine diacyl C40:6 levels
Affymetrix, Illumina [5791022] (imputed)
Phosphatidylcholine diacyl C42:0 levels
16,118 Caucasian ancestry individuals
Affymetrix, Illumina [5791949] (imputed)
Phosphatidylcholine diacyl C42:1 levels
16,570 Caucasian ancestry individuals
Affymetrix, Illumina [5791842] (imputed)
Phosphatidylcholine diacyl C42:4 levels
16,611 Caucasian ancestry individuals
Affymetrix, Illumina [5793588] (imputed)
Phosphatidylcholine diacyl C42:5 levels
16,508 Caucasian ancestry individuals
Affymetrix, Illumina [5792227] (imputed)
Phosphatidylcholine diacyl C42:6 levels
15,749 Caucasian ancestry individuals
Affymetrix, Illumina [6084545] (imputed)
Phosphatidylcholine acyl-alkyl C30:1 levels
9,003 Caucasian ancestry individuals
Affymetrix, Illumina [6083739] (imputed)
Phosphatidylcholine acyl-alkyl C30:2 levels
9,286 Caucasian ancestry individuals
Affymetrix, Illumina [6083559] (imputed)
Phosphatidylcholine acyl-alkyl C32:1 levels
Affymetrix, Illumina [5791633] (imputed)
Phosphatidylcholine acyl-alkyl C32:2 levels
Affymetrix, Illumina [5792117] (imputed)
Phosphatidylcholine acyl-alkyl C34:1 levels
Affymetrix, Illumina [5791726] (imputed)
Phosphatidylcholine acyl-alkyl C34:2 levels
Affymetrix, Illumina [5791125] (imputed)
Phosphatidylcholine acyl-alkyl C34:3 levels
Affymetrix, Illumina [5790966] (imputed)
Phosphatidylcholine acyl-alkyl C36:2 levels
Affymetrix, Illumina [5791425] (imputed)
Phosphatidylcholine acyl-alkyl C36:3 levels
Affymetrix, Illumina [5791531] (imputed)
Phosphatidylcholine acyl-alkyl C36:4 levels
Phosphatidylcholine acyl-alkyl C36:5 levels
Affymetrix, Illumina [5791674] (imputed)
Phosphatidylcholine acyl-alkyl C38:0 levels
Affymetrix, Illumina [5791382] (imputed)
Phosphatidylcholine acyl-alkyl C38:1 levels
15,899 Caucasian ancestry individuals
Affymetrix, Illumina [6085896] (imputed)
Phosphatidylcholine acyl-alkyl C38:2 levels
Affymetrix, Illumina [5792947] (imputed)
Phosphatidylcholine acyl-alkyl C38:3 levels
Affymetrix, Illumina [5792424] (imputed)
Phosphatidylcholine acyl-alkyl C38:4 levels
Affymetrix, Illumina [5791693] (imputed)
Phosphatidylcholine acyl-alkyl C38:5 levels
Phosphatidylcholine acyl-alkyl C38:6 levels
Affymetrix, Illumina [5791449] (imputed)
Phosphatidylcholine acyl-alkyl C40:1 levels
16,765 Caucasian ancestry individuals
Affymetrix, Illumina [5792181] (imputed)
Phosphatidylcholine acyl-alkyl C40:3 levels
Affymetrix, Illumina [5793024] (imputed)
Phosphatidylcholine acyl-alkyl C40:4 levels
Affymetrix, Illumina [5792704] (imputed)
Phosphatidylcholine acyl-alkyl C40:5 levels
Affymetrix, Illumina [5792541] (imputed)
Phosphatidylcholine acyl-alkyl C40:6 levels
Affymetrix, Illumina [5791707] (imputed)
Phosphatidylcholine acyl-alkyl C42:1 levels
Affymetrix, Illumina [5792614] (imputed)
Phosphatidylcholine acyl-alkyl C42:2 levels
Affymetrix, Illumina [5792187] (imputed)
Phosphatidylcholine acyl-alkyl C42:3 levels
Affymetrix, Illumina [5791892] (imputed)
Phosphatidylcholine acyl-alkyl C42:4 levels
Affymetrix, Illumina [5792022] (imputed)
Phosphatidylcholine acyl-alkyl C42:5 levels
Affymetrix, Illumina [6084572] (imputed)
Phosphatidylcholine acyl-alkyl C44:5 levels
16,685 Caucasian ancestry individuals
Affymetrix, Illumina [5791751] (imputed)
Phosphatidylcholine acyl-alkyl C44:6 levels
16,564 Caucasian ancestry individuals
Affymetrix, Illumina [5791983] (imputed)
Sphingomyeline C16:0 levels
31,023 Caucasian ancestry individuals
Affymetrix, Illumina [6046342] (imputed)
Sphingomyeline C16:1 levels
Affymetrix, Illumina [5791919] (imputed)
Sphingomyeline C18:0 levels
31,120 Caucasian ancestry individuals
Affymetrix, Illumina [6058838] (imputed)
Sphingomyeline C18:1 levels
Affymetrix, Illumina [5791473] (imputed)
Sphingomyeline C20:2 levels
16,762 Caucasian ancestry individuals
Affymetrix, Illumina [5791217] (imputed)
Sphingomyeline C24:0 levels
Sphingomyeline C24:1 levels
Affymetrix, Illumina [5792136] (imputed)
Hydroxysphingomyeline C14:1 levels
Affymetrix, Illumina [5791165] (imputed)
Hydroxysphingomyeline C16:1 levels
Affymetrix, Illumina [6083887] (imputed)
Hydroxysphingomyeline C22:1 levels
Affymetrix, Illumina [6084448] (imputed)
Hydroxysphingomyeline C22:2 levels
15,757 Caucasian ancestry individuals
Affymetrix, Illumina [6084053] (imputed)
Affymetrix, Illumina [5791391] (imputed)
Liver fibrogenesis (alpha smooth muscle actin levels)
102 European ancestry individuals, 19 African ancestry individuals
Liver fibrosis (total hepatic collagen content)
1,552 European ancestry individuals
2,116 European ancestry cases, 24,626 European ancestry controls
1, 389 European ancestry cases, 79,727 European ancestry controls, 759 South Asian ancestry cases, 8,009 South Asian ancestry controls, 405 African ancestry cases, 4,185 African ancestry controls
17,068 European ancestry cases, 357,219 European ancestry controls, 3,848 African ancestry cases, 5,897 African ancestry controls
QT dynamics during exercise
28,449 European ancestry women, 24,412 European ancestry men
QT dynamics during recovery from exercise
Kynurenine levels
30,899 Caucasian ancestry individuals
Affymetrix, Illumina [6046416] (imputed)
Arginine levels
30,724 Caucasian ancestry individuals
Affymetrix, Illumina [6046728] (imputed)
trans-Hydroxyproline levels
30,895 Caucasian ancestry individuals
Affymetrix, Illumina [6046415] (imputed)
Aspartate levels
30,775 Caucasian ancestry individuals
Affymetrix, Illumina [6046296] (imputed)
Citrulline levels
30,940 Caucasian ancestry individuals
Affymetrix, Illumina [6046410] (imputed)
85,821 Caucasian ancestry individuals
Affymetrix, Illumina [6051950] (imputed)
31,001 Caucasian ancestry individuals
Affymetrix, Illumina [6046392] (imputed)
Acetylcarnitine levels
31,008 Caucasian ancestry individuals
Affymetrix, Illumina [6046365] (imputed)
Propionylcarnitine levels
32,590 Caucasian ancestry individuals
Affymetrix, Illumina [6045556] (imputed)
Butyrylcarnitine levels
30,694 Caucasian ancestry individuals
Affymetrix, Illumina [6046389] (imputed)
30,982 Caucasian ancestry individuals
Affymetrix, Illumina [6046356] (imputed)
Methylglutarylcarnitine levels
22,335 Caucasian ancestry individuals
Affymetrix, Illumina [6093101] (imputed)
Hexanoylcarnitine levels
Affymetrix, Illumina [6083013] (imputed)
Pimelylcarnitine levels
15,119 Caucasian ancestry individuals
Affymetrix, Illumina [6083180] (imputed)
Octanoylcarnitine levels
31,969 Caucasian ancestry individuals
Affymetrix, Illumina [6043492] (imputed)
Nonaylcarnitine levels
13,925 Caucasian ancestry individuals
Affymetrix, Illumina [6083678] (imputed)
Decanoylcarnitine levels
31,934 Caucasian ancestry individuals
Affymetrix, Illumina [6043651] (imputed)
Decenoylcarnitine levels
15,116 Caucasian ancestry individuals
Affymetrix, Illumina [6083730] (imputed)
85,641 Caucasian ancestry individuals
Affymetrix, Illumina [6051188] (imputed)
Dodecenoylcarnitine levels
Affymetrix, Illumina [5791491] (imputed)
Symmetric dimethylarginine levels
9,256 Caucasian ancestry individuals
Affymetrix, Illumina [6083518] (imputed)
Tetradecenoylcarnitine levels
31,105 Caucasian ancestry individuals
Affymetrix, Illumina [6058849] (imputed)
Tetradecadienylcarnitine levels
15,118 Caucasian ancestry individuals
Affymetrix, Illumina [6083929] (imputed)
Hexadecanoylcarnitine levels
30,915 Caucasian ancestry individuals
Affymetrix, Illumina [6046326] (imputed)
Hexadecenoylcarnitine levels
14,370 Caucasian ancestry individuals
Affymetrix, Illumina [6077273] (imputed)
744 Spanish ancestry cases, 1,454 Spanish ancestry controls
1,430 cases, 1,417 controls
1,173 Japanese cases, 8.925 Japanese controls, 20,806 European ancestry cases, 53,439 European ancestry controls
1,234 Chinese ancestry cases, 2,850 Chinese ancestry controls, 707Japanese ancestry cases, 971 Japanese ancestry controls
Long QT syndrome
1,238 European ancestry cases, 8,219 European ancestry controls, 418 Japanese cases, 1,617 Japanese controls
Cardio-cerebrovascular disease in hypertension
1,185 Korean ancestry cases, 15,117 Korean ancestry controls
Coronary artery disease in hypertension
816 Korean ancestry cases, 15,488 Korean ancestry controls
Ischemic stroke in hypertension
398 Korean ancestry cases, 15,909 Korean ancestry controls
Cardio-cerebrovascular disease in diabetes mellitus
497 Korean ancestry cases, 4,815 Korean ancestry controls
361 Korean ancestry cases, 4,951 Korean ancestry controls
Ischemic stroke in diabetes mellitus
153 Korean ancestry cases, 5,161 Korean ancestry controls
Cardio-cerebrovascular disease in dyslipidemia
1,039 Korean ancestry cases, 19,727 Korean ancestry controls
Coronary artery disease in dyslipidemia
768 Korean ancestry cases, 19,999 Korean ancestry controls
Ischemic stroke in dyslipidemia
295 Korean ancestry cases, 20,474 Korean ancestry controls
Creutzfeldt-Jakob disease (sporadic)
4,110 European ancestry cases, 13,569 European ancestry controls
1,098 European ancestry cases, 498 ,016 European ancestry controls
Affymetrix, Illumina [6314492] (imputed)
524,923 European ancestry individuals
Affymetrix, Illumina [50265552] (imputed)
89,266 East Asian ancestry individuals
Affymetrix, Illumina [16289068] (imputed)
7,541 Hispanic or Latin American individuals
Affymetrix, Illumina [25652707] (imputed)
8,163 South Asian ancestry individuals
Affymetrix, Illumina [28469925] (imputed)
643,370 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [23472807] (imputed)
11,974 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36043646] (imputed)
486,823 European ancestry individuals
Affymetrix, Illumina [50266654] (imputed)
119,629 East Asian ancestry individuals
Affymetrix, Illumina [16286228] (imputed)
3,518 Hispanic or Latin American individuals
Affymetrix, Illumina [24999652] (imputed)
8,181 South Asian ancestry individuals
Affymetrix, Illumina [28486451] (imputed)
630,125 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [20825802] (imputed)
12,766 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36221496] (imputed)
491,553 European ancestry individuals
Affymetrix, Illumina [50282193] (imputed)
126,151 East Asian ancestry individuals
Affymetrix, Illumina [16289083] (imputed)
Affymetrix, Illumina [24999636] (imputed)
8,185 South Asian ancestry individuals
Affymetrix, Illumina [28487724] (imputed)
642,173 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [21126107] (imputed)
14,222 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36679766] (imputed)
544,127 European ancestry individuals
Affymetrix, Illumina [50615308] (imputed)
121,047 East Asian ancestry individuals
Affymetrix, Illumina [16286195] (imputed)
9,298 Hispanic or Latin American individuals
Affymetrix, Illumina [26810224] (imputed)
8,188 South Asian ancestry individuals
Affymetrix, Illumina [28492174] (imputed)
696,882 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [24246363] (imputed)
13,471 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36452625] (imputed)
521,594 European ancestry individuals
Affymetrix, Illumina [50262088] (imputed)
13,435 European ancestry cases, 393,186 European ancestry controls
Nonatopic asthma
28,862 European ancestry cases, 422,048 European ancestry controls
Atopic asthma
23,982 European ancestry cases, 393,169 European ancestry controls
457,690 European ancestry individuals
457,822 European ancestry individuals
Adult onset asthma and/or BMI
33,418 European ancestry cases, 393,186 European ancestry controls, 31,218 European ancestry individuals
Nonatopic asthma and/or BMI
28,862 European ancestry cases, 422,048 European ancestry controls, 6,912 European ancestry individuals
Adult onset asthma and/or waist-to-hip ratio adjusted for BMI
33,418 European ancestry cases, 393,186 European ancestry controls, 31,086 European ancestry individuals
Nonatopic asthma and/or waist-to-hip ratio adjusted for BMI
28,862 European ancestry cases, 422,048 European ancestry controls, 6,780 European ancestry individuals
Adult onset asthma or type 2 diabetes
33,418 European ancestry asthma cases, 393,186 European ancestry asthma controls, 159,208 European ancestry diabetes cases and controls
Nonatopic asthma or type 2 diabetes
28,862 European ancestry asthma cases, 422,048 European ancestry asthma controls, 159,208 European ancestry diabetes cases and controls
Adult onset asthma or fasting insulin levels
33,418 European ancestry cases, 393,186 European ancestry controls, 51,750 European ancestry individuals
Nonatopic asthma or fasting insulin levels
28,862 European ancestry cases, 422,048 European ancestry controls, 51,750 European ancestry individuals
Adult onset asthma or fasting glucose levels
33,418 European ancestry cases, 393,186 European ancestry controls, 58,047 European ancestry individuals
Nonatopic asthma or fasting glucose levels
28,862 European ancestry cases, 422,048 European ancestry controls, 58,047 European ancestry individuals
33,418 European ancestry cases, 393,186 European ancestry controls
88,929 East Asian ancestry individuals
Affymetrix, Illumina [16289044] (imputed)
7,543 Hispanic or Latin American individuals
Affymetrix, Illumina [25652698] (imputed)
7,043 South Asian ancestry individuals
Affymetrix, Illumina [28465834] (imputed)
639,696 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [23467995] (imputed)
10,737 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36042313] (imputed)
460,935 European ancestry individuals
Affymetrix, Illumina [49660172] (imputed)
2,810 Hispanic or Latin American individuals
Affymetrix, Illumina [24878602] (imputed)
8,189 South Asian ancestry individuals
Affymetrix, Illumina [28493265] (imputed)
484,042 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [17210439] (imputed)
13,476 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36456987] (imputed)
519,288 European ancestry individuals
Affymetrix, Illumina [50250472] (imputed)
78,744 East Asian ancestry individuals
Affymetrix, Illumina [16289093] (imputed)
7,542 Hispanic or Latin American individuals
Affymetrix, Illumina [25652697] (imputed)
8,165 South Asian ancestry individuals
Affymetrix, Illumina [28471362] (imputed)
627,215 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [23114412] (imputed)
15,171 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36877391] (imputed)
542,827 European ancestry individuals
Affymetrix, Illumina [50241410] (imputed)
145,648 East Asian ancestry individuals
Affymetrix, Illumina [16710488] (imputed)
9,367 Hispanic or Latin American individuals
Affymetrix, Illumina [26925389] (imputed)
Affymetrix, Illumina [28492373] (imputed)
721,201 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [24588908] (imputed)
Affymetrix, Illumina [36679691] (imputed)
545,203 European ancestry individuals
Affymetrix, Illumina [50628390] (imputed)
150,708 East Asian ancestry individuals
Affymetrix, Illumina [16709798] (imputed)
9,302 Hispanic or Latin American individuals
Affymetrix, Illumina [26810348] (imputed)
Neuritic plaques (SNP x SNP interaction)
1,316 individuals
Diffuse plaques (SNP x SNP interaction)
Total PHF-tau (SNP x SNP interaction)
1,285 individuals
Total amyloid (SNP x SNP interaction)
1,276 individuals
Neurofibrillary tangles (SNP x SNP interaction)
Coronary heart disease event reduction (statin therapy interaction)
682 European, African American, Hispanic, Asian, Pacific Islander and other ancestry cases with events, 383 cases with events
29 European, African American, Hispanic, Asian, Pacific Islander and other ancestry cases with events, 2,398 European, African American, Hispanic, Asian, Pacific Islander and other ancestry cases without events, 729 cases with events, 9,563 cases without events
196 European ancestry cases
8,841 Korean ancestry individuals
1,096 Korean ancestry individuals
HIV-associated dementia
1,287 European ancestry HIV-infected male individuals
Duodenal ulcer
1,043 Japanese ancestry cases, 21,694 Japanese ancestry controls
5,992 Japanese ancestry cases, 3,629 Japanese ancestry controls
77 European ancestry individuals, 32 African American individuals, 30 individuals
183 European ancestry individuals, 22 African American individuals
3,023 European ancestry cases, 8,779 European ancestry controls
2,111 European ancestry cases, 4,483 European ancestry controls
466 European ancestry cases, 377 African American cases, 46 East Asian, Asian, and other ancestry cases, 523 European ancestry controls, 357 African American controls, 47 East Asian, Asian, and other ancestry controls
1,586 European ancestry cases, 2,690 European ancestry controls
Up to 13,627 European ancestry individuals
Up to 16,253 European ancestry individuals
22,762 East Asian ancestry individuals, 2,522 Malay ancestry individuals, 2,431 Chinese, Malay and Asian Indian ancestry individuals
53,215 East Asian ancestry results, 2,118 Malay ancestry individuals
Affymetrix, Illumina [2474474] (imputed)
IFN-related cytopenia
984 European ancestry with genotype 1 HCV cases, 201 African American genotype 1 HCV cases, 99 Hispanic genotype 1 HCV cases
Paget's disease
741 European ancestry cases, 2,699 European ancestry controls
1,474 European ancestry cases, 1,671 European ancestry controls
22,275 East Asian ancestry individuals, 4,325 South East Asian ancestry individuals
28,783 East Asian ancestry individuals
Adolescent idiopathic scoliosis (severe)
554 Japanese ancestry cases, 1,474 Japanese ancestry controls
839 East Asian ancestry cases, 10,149 East Asian ancestry controls
1,450 European ancestry individuals
Phospholipid levels (plasma)
4,034 European ancestry individuals
Sexual dimorphism in anthropometric traits
up to 60,586 European ancestry males, up to 73,137 European ancestry females
up to 62,395 European ancestry males, up to 74,657 European ancestry females
Affymetrix, Illumina [2846694] (imputed)
1,782 Filipino ancestry mothers
1,719 Filipino ancestry offsprings
Weight loss (gastric bypass surgery)
86 European ancestry individuals with least EBWL, 89 European ancestry individuals with most EBWL
164 European ancestry individuals with least EBWL, 169 European ancestry individuals with most EBWL
Adverse response to chemotherapy in breast cancer (alopecia)
303 Japanese ancestry cases, 880 Japanese ancestry controls
23 Japanese ancestry cases
Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU)
116 Japanese ancestry cases, 108 Japanese ancestry controls
Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU)
64 Japanese ancestry cases, 27 Japanese ancestry controls
Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel)
57 Japanese ancestry cases, 63 Japanese ancestry controls
Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel)
62 Japanese ancestry cases, 42 Japanese ancestry controls
Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule)
119 Japanese ancestry cases, 105 Japanese ancestry controls
1,645 European ancestry cases, 881 European ancestry controls, 281 African ancestry cases, 185 African ancestry controls
491 European ancestry cases, 479 European ancestry controls
107 European ancestry cases, 134 European ancestry controls
583 European ancestry cases, 1,357 European ancestry controls from 583 families
11,085 European ancestry cases, 11,463 European ancestry controls
19,662 European ancestry cases, 19,715 European ancestry controls
400 Korean ancestry cases, 1,000 Korean ancestry controls
971 Korean ancestry cases, 1,938 Korean ancestry controls
Up to 403 European ancestry asthmatic children and their parents
764 European ancestry cases, 592 Costa Rican ancestry cases
1,292 European ancestry cases, 30,503 European ancestry controls
3,267 European ancestry cases, 7,451 European ancestry controls
371 European ancestry cases, 1,263 European ancestry controls
4,915 European ancestry cases, 8,159 European ancestry controls
1,532 Japanese ancestry cases, 3,304 Japanese ancestry controls
5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls
2,594 European ancestry cases, 4,134 European ancestry controls
5,640 European ancestry cases, 52,174 European ancestry controls
458 Japanese ancestry cases, 2,056 Japanese ancestry controls
2,209 Japanese ancestry cases, 4,440 Japanese ancestry controls
2,918 Chinese ancestry cases, 2,324 Chinese ancestry controls
up to 16,173 East Asian ancestry cases, up to 18,282 East Asian ancestry controls
535 European ancestry cases, 3,432 European ancestry controls
1,931 European ancestry cases, 6,785 European ancestry controls
Metabolite levels (Dihydroxy docosatrienoic acid)
1,260 African American individuals
Metabolite levels (Pyroglutamine)
Metabolite levels (X-11787)
300 European ancestry cases, up to 1,538 European ancestry controls, 444 African American cases, up to 2,936 African American controls
207 European ancestry cases, up to 1,692 European ancestry controls, 89 African American cases, up to 655 African American controls
Post-traumatic stress disorder (asjusted for relatedness)
up to 308 European ancestry cases, up to 1,538 European ancestry controls, up to 456 African American cases, up to 2,936 African American controls
4,147 European ancestry cases, 7,435 European ancestry controls
Substance dependence
2,524 European ancestry individuals, 1,103 African ancestry individuals
69,395 European ancestry individuals
Up to 133,361 European ancestry individuals
1,119 Japanese ancestry cases, 2,718 Japanese ancestry controls
432 Japanese ancestry cases, 1,157 Japanese ancestry controls
428 Japanese ancestry cases, 3,379 Japanese ancestry controls
754 Japanese ancestry cases, 947 Japanese ancestry controls
581 European ancestry male cases, 617 European ancestry male controls
461 European ancestry male cases, 151 European ancestry male controls
1,040 African American individuals
1,030 European ancestry cases, 1,195 European ancestry controls
315 Hong Kong Chinese ancestry individuals from 111 families
848 Black cases
305 Black cases, 406 Chinese ancestry cases, 113 Thai ancestry cases
117 Korean ancestry cases, 279 Korean ancestry controls
504 Korean ancestry cases, 471 Korean ancestry controls
792 European ancestry cases, 37,592 European ancestry controls
469 European ancestry cases, 1,185 European ancestry controls
Up to 123,865 European ancestry individuals
Up to 125,931 European ancestry individuals
Affymetrix, Illumina, Perlegen [~ 2800000] (imputed)
1,022 European ancestry cases, 2,503 European ancestry controls
1,387 European ancestry cases, 1,115 European ancestry controls
1,265 European ancestry cases, 5,190 European ancestry controls
3,957 European ancestry cases, 6,886 European ancestry controls
Addiction
560 African American cases, 360 African American controls, 420 European ancestry cases, 680 European ancestry controls
1,087 European ancestry individuals
~8,100 European ancestry individuals
13,106 European ancestry individuals, 1,652 Val Borbera (founder/genetic isolate) individuals, 593 Carlantino (founder/genetic isolate) individuals, 1,146 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,213 South Tyrolean (founder/genetic isolate) individuals, 890 Sorbian (founder/genetic isolate) individuals
Up to 16,960 European ancestry individuals, 855 Cliento (founder/genetic isolate) individuals, 1,023 Talana (founder/genetic isolate) individuals
38,891 European ancestry individuals, 1,661 Val Borbera (founder/genetic isolate) individuals, 521 Carlantino (founder/genetic isolate) individuals, 1,198 Friuli Venezia Giulia (founder/genetic isolate) individuals, 1,213 South Tyrolean (founder/genetic isolate) individuals, 890 Sorbian (founder/genetic isolate) individuals, 4,292 Sardinian (founder/genetic isolate) individuals
Up to 16,949 European ancestry individuals, 854 Cliento (founder/genetic isolate) individuals, 1,035 Talana (founder/genetic isolate) individuals
1,144 Hutterite individuals
6,334 European ancestry cases, 7,247 European ancestry controls
342 European ancestry cases, 643 European ancestry controls
4,651 European ancestry cases, 6,966 European ancestry controls
Uric acid levels (SNP x SNP interaction)
1,201 European ancestry individuals
4,641 European ancestry individuals
1,383 Japanese ancestry cases, 5,484 Japanese ancestry controls
1,048 Japanese ancestry cases, 7,212 Japanese ancestry controls
315 Han Chinese ancestry individuals, 1,999 European ancestry cases, 3,004 European ancestry controls
387 European ancestry cases, 496 European ancestry controls
Fasting blood insulin (BMI interaction)
Up to 51,750 European ancestry individuals
Up to 33,823 European ancestry individuals
Fasting blood glucose (BMI interaction)
Up to 58,074 European ancestry individuals
Up tp 38,422 European ancestry individuals
622 Han Chinese ancestry cases, 1,107 Han Chinese ancestry controls
261 Han Chinese ancestry cases, 550 Han Chinese ancestry controls
533 African American individuals
432 African American individuals
Up to 499 European ancestry cases
1,207 European ancestry cases
2,296 European ancestry cases, 5,172 European ancestry controls
3,175 European ancestry cases, 4,210 European ancestry controls
1,515 Han Chinese ancestry cases, 5,019 Han Chinese ancestry controls
15,460 Han Chinese ancestry cases, 11,472 Han Chinese ancestry controls
Aging (time to death)
25,007 European ancestry individuals
10,411 European ancestry individuals
Aging (time to event)
16,995 European ancestry individuals
282 European ancestry children, 66 African American children, 63 Hispanic children
1,627 European ancestry individuals, 1,478 African ancestry individuals, 1,443 Hispanic individuals
Wegener's granulomatosis
459 European ancestry cases, 1,503 European ancestry controls
291 European ancestry cases, 317 European ancestry controls
528 European ancestry cases, 1,228 European ancestry controls
973 incident AD cases, 2,033 prevalent AD cases, 22,604 controls of European and Hispanic ancestry
6,505 European ancestry cases, 13,532 European ancestry controls
899 Japanese ancestry cases, 3,396 Japanese ancestry controls
167 Japanese ancestry cases, 347 Japanese ancestry controls, 813 European ancestry cases, 1,071 European ancestry controls,
Local histogram emphysema pattern
3,732 European ancestry smoker individuals, 2,724 European ancestry chronic obstructive pulmonary disease smoker cases, 2,372 African American smoker individuals, 786 African American chronic obstructive pulmonary disease smoker cases
Parasitemia in Tripanosoma cruzi seropositivity
580 Brazilian ancestry individuals
QRS duration in Tripanosoma cruzi seropositivity
Chagas cardiomyopathy in Tripanosoma cruzi seropositivity
207 Brazilian ancestry cases, 306 Brazilian ancestry controls
Antibody status in Tripanosoma cruzi seropositivity
PR interval in Tripanosoma cruzi seropositivity
QT interval in Tripanosoma cruzi seropositivity
Ejection fraction in Tripanosoma cruzi seropositivity
206 European ancestry trios
81 African American female cases, 261 African American female controls, 10 European ancestry female cases, 35 European ancestry female controls, 3 female cases, 22 female controls
578 European ancestry female cases, 1,963 European ancestry female controls
185 European ancestry low NFT individuals, 114 European ancestry high NFT individuals
Multiple sclerosis or amyotrophic lateral sclerosis
4,088 Multiple sclerosis cases, 3,762 Amyotrophic lateralsclerosis cases, 12,030 controls
914 European ancestry cases, 5,259 European ancestry controls
1,454 European ancestry cases, 1,666 European ancestry controls
31 Amish cases, 767 Amish controls
Retinal arteriolar caliber
18,722 European ancestry individuals
3,939 European ancestry individuals
938 Japanese ancestry cases, 2,376 Japanese ancestry controls
1653 East Asian ancestry cases, 1453 East Asian ancestry controls
Eating disorders
Up to 2,567 European ancestry individuals
Up to 767 European ancestry cases, up to 486 European ancestry controls
781 European ancestry cases, 3,992 European ancestry controls
Hepatitis B vaccine response
1,683 Indonesian ancestry individuals
1,931 Indonesian ancestry individuals
268 Ashkenazi Jewish cases, 178 Ashkenazi Jewish controls
1,782 European ancestry cases, 1,658 European ancestry controls
102 Han Chinese ancestry cases, 335 Han Chinese ancestry controls
2,891 Han Chinese ancestry cases, 10,071 Han Chinese ancestry controls
409 European and other ancestry bipolar cases
693 European ancestry individuals
15,864 European ancestry cases, 19,610 European ancestry controls
108 Indonesian ancestry cases, 115 Indonesian ancestry controls
600 Indonesian ancestry cases, 540 Indonesian ancestry controls, 1,837 European ancestry cases, 1,779 European ancestry controls
5,001 European ancestry cases, 6,243 European ancestry controls, 8,832 cases, 12,067 controls
4,801 European ancestry cases, 4,741 European ancestry controls, 2,612 European and unknown ancestry cases, 15,021 European and unknown ancestry controls, 581 trios
684 Han Chinese ancestry cases, 955 Han Chinese ancestry controls
18,954 East Asian ancestry cases, 18,029 East Asian ancestry controls, 794 Malay ancestry cases, 1,204 Malay ancestry controls, 977 Indian ancestry cases, 1,169 Indian ancestry controls, 8,130 European ancestry cases, 38,987 European ancestry controls
66 Arab ancestry cases and 112 Arab ancestry controls from one extended family
116 Arab ancestry cases, 199 Arab ancestry controls
141 European ancestry cases, 141 European ancestry controls
Temperament
Up to 12,433 European ancestry individuals
Affymetrix, Illumina [1252222] (imputed)
Up to 12,924 European ancestry cases, up to 21,442 European ancestry controls
Up to 25,683 European ancestry cases, up to 17,015 European ancestry controls
Affymetrix, Illumina [1230000] (imputed)
12,924 European ancestry cases, 21,442 European ancestry controls
25,683 European ancestry cases, 17,015 European ancestry controls
Insomnia (caffeine-induced)
2,402 European ancestry individuals from 1,470 families
6,989 European ancestry individuals
859 European ancestry cases, 704 European ancestry controls
774 European ancestry cases, 1,764 European ancestry controls
80 Japanese ancestry cases, 194 Japanese ancestry controls
2,889 European ancestry children and adolescents
3,659 European ancestry children
20,926 European ancestry individuals, 2,895 African ancestry individuals
Affymetrix, Illumina [2478304] (imputed)
23,812 European ancestry individuals
16,626 European ancestry individuals
611 Japanese ancestry cases, 737 Japanese ancestry controls
119 Korean ancestry cases, 140 Korean ancestry controls, 1,215 Turkish cases, 1,279 Turkish controls
5,117 European ancestry individuals from 2567 families
Affymetrix, Illumina [1252387] (imputed)
33,398 cases, 75,726 controls
12,389 cases, 62,004 controls
2,167 cases, 49,159 controls
Coronary artery disease or ischemic stroke
12,389 Ischemic stroke cases, 22,233 Coronary artery disease cases, ~ 88,766 controls
Coronary artery disease or large artery stroke
2,167 Large artery stroke cases, 22,233 Coronary artery disease cases, ~ 75,921 controls
1,657 Val Borbera (founder/genetic isolate) individuals
Aortic stiffness
4,216 Sardinian individuals, 20,634 European ancestry individuals
5,306 European ancestry individuals
Response to rate control therapy in atrial fibrillation
95 non-responders, 190 responders
130 non-responders, 157 responders
Breast cancer (prognosis)
1,145 female individuals
4,335 European ancestry female individuals
1,999 Chinese ancestry male individuals
1,496 Chinese ancestry male individuals
Neural processing (facial expression)
246 European ancestry individuals
85 European ancestry individuals
5,976 Japanese ancestry cases, 20,829 Japanese ancestry controls
24,416 East Asian ancestry cases, 13,985 East Asian ancestry controls
746 Han Chinese ancestry cases, 1,599 Han Chinese ancestry controls
4,027 Han Chinese ancestry cases, 5,603 Han Chinese ancestry controls
17 Korean ancestry cases, 123 Korean ancestry controls
32 Korean ancestry cases, 191 Korean ancestry controls
4,443 European ancestry older adult individuals
188 European ancestry cases, 376 European ancestry controls
99 European ancestry cases, 328 European ancestry controls
Alzheimer's disease (neuritic plaque pathology)
651 European and unknown ancestry individuals
114 individuals
5,530 European ancestry cases, 8,318 European ancestry controls
2,214 European ancestry cases, 2,674 European ancestry controls
37,537 European ancestry individuals
33,533 European ancestry individuals
41,257 European ancestry individuals
Handedness in dyslexia
192 individuals
573 European ancestry individuals
White matter integrity
535 European ancestry individuals
1,317 European ancestry cases, 5,053 European ancestry controls
263 European ancestry cases, 1,616 European ancestry controls
379 European ancestry cases, 791 European ancestry controls
1,049 European ancestry cases, 3,952 European ancestry controls
12,126 European ancestry individuals, 1,538 individuals
Affymetrix, Illumina [2661766] (imputed)
12,046 European ancestry individuals, 1,487 African ancestry individuals
Coronary restenosis
295 European ancestry cases, 571 European ancestry controls
455 European ancestry cases, 2,880 European ancestry controls
2,167 African American cases, 2,288 African American controls
2,820 European ancestry individuals
1,122 Mexican ancestry cases, 1,118 Mexican ancestry controls
1,067 Mexican ancestry cases, 1,054 Mexican ancestry controls
1,122 Mexican ancestry hypertriglyceridemia cases, 1,118 Mexican ancestry controls
1,067 Mexican ancestry hypertriglyceridemia cases, 1,054 Mexican ancestry controls
105 Korean ancestry cases
189 Korean ancestry cases, 190 Korean ancestry controls
Up to 813 European ancestry individuals, up to 167 East Asian ancestry individuals, up to 7 Hispanic/Latin American individuals, up to 74 South Asian ancestry individuals
5,752 European ancestry related individuals
5,919 European ancestry related individuals
737 Ashkenazi Jewish cases, 2,257 Ashkenazi Jewish controls
971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls
Affymetrix, Illumina [1060934] (imputed)
2,073 Chinese ancestry cases, 2,084 Chinese ancestry controls
15,159 East Asian ancestry cases, 12,993 East Asian ancestry controls, 2,797 European ancestry cases, 2,662 European ancestry controls
1,333 European ancestry male cases, 2,168 European ancestry male controls
Nevirapine-induced rash
72 Thai ancestry nevirapine-induced rash HIV cases, 77 Thai ancestry nevirapine-tolerant rash HIV cases
88 Thai ancestry nevirapine-induced rash HIV cases, 145 Thai ancestry nevirapine-tolerant HIV cases
195 Japanese ancestry cases, 1,358 Japanese ancestry controls
699 Japanese ancestry cases, 1,540 Japanese ancestry controls
1,468 Chinese ancestry cases, 1,490 Chinese ancestry controls
3,994 Chinese ancestry cases, 3,510 Chinese ancestry controls
2,197 cases, 2,061 controls
Up to 98,080 European and Asian ancestry individuals
4,768 Japanese ancestry cases, 17,359 Japanese ancestry controls
6,483 European and Middle East/North African ancestry cases, 23,324 European and Middle East/North African ancestry controls
6,078 individuals
1,231 European ancestry individuals
38,968 European ancestry female individuals
Up to 14,435 European ancestry female individuals
Affymetrix, Illumina [2551160] (imputed)
Schizophrenia (cytomegalovirus infection interaction)
888 European ancestry cases, 882 European ancestry controls
2539 European ancestry cases, 5486 European ancestry controls
496 African ancestry cases
496 African ancestry cases and 302 African ancestry exposed controls from serodiscordant couples
27,758 European ancestry individuals
1,156 European ancestry cases, up to 42,617 European ancestry controls
Callous-unemotional behaviour
2,930 European ancestry children
1,705 European ancestry cases, 5,175 European ancestry controls
933 European ancestry cases, 3,346 European ancestry controls
231 European ancestry cases, 1,345 European ancestry controls
181 East Asian ancestry HBV carriers, 184 East Asian ancestry controls, 185 East Asian ancestry spontaneously HBV-resolved individuals
Up to 8,045 East Asian ancestry HBV carriers, up to 9,003 East Asian ancestry controls, up to 3,995 East Asian ancestry spontaneously HBV-resolved individuals
3,146 European ancestry cases, 3,487 European ancestry controls
11,972 European ancestry individuals
Male fertility
269 Hutterite males
43 Solomon Islander ancestry blond haired individuals, 42 Solomon Islander ancestry dark haired individuals
1,434 Han Chinese ancestry cases, 4,270 Han Chinese ancestry controls
2,703 Han Chinese ancestry cases, 3,464 Han Chinese ancestry controls
564 European ancestry cases, 1,776 European ancestry controls
1,682 European ancestry cases, 3,926 European ancestry controls
2,234 European ancestry cases, 41,603 European ancestry controls
3,371 European ancestry cases, 10,261 European ancestry controls, 269 Iranian ancestry cases, 246 Iranian ancestry controls
522 Han Chinese ancestry cases, 806 Han Chinese ancestry controls
273 Han Chinese ancestry cases
90 Tunisian ancestry cases, 131 Tunisian ancestry controls
155 Arab ancestry cases, 182 Arab ancestry controls
Drug-induced liver injury (amoxicillin-clavulanate)
201 European ancestry cases, 532 European ancestry controls
490 Chinese ancestry cases, 490 Chinese ancestry controls
521 Chinese ancestry cases, 524 Chinese ancestry controls
922 European ancestry cases, 1,526 European ancestry controls
3,935 European ancestry cases, 5,754 European ancestry controls
Antipsychotic drug-induced QTc interval prolongation
738 European, African American, Hispanic, and other ancestry Schizophrenia cases
4,001 Korean ancestry individuals
2,304 Korean ancestry individuals
Haptoglobin levels
631 European ancestry children
2,957 European ancestry family members, 1,434 European ancestry individuals
Dialysis-related mortality
610 African American type 2 diabetes cases
2,326 European ancestry cases, 4,580 European ancestry controls
2,508 European ancestry cases, 2,652 European ancestry controls
1,393 European ancestry females, 1,131 European ancestry males, 568 African ancestry females, 535 African ancestry males
7,410 European ancestry cases, 11,009 European ancestry controls
7,473 European ancestry cases, 42,938 European ancestry controls
Fat distribution (HIV)
192 European ancestry male cases
Cerivastatin-induced rhabdomyolysis
168 European ancestry cases, 636 European ancestry controls, 17 cases, 96 controls
Femoral neck bone geometry and menarche (age at onset)
1,728 European ancestry individuals
501 European ancestry individuals, 826 Chinese ancestry individuals
653 European ancestry high HDL-C individuals, 784 European ancestry low HDL-C individuals
496 European ancestry high HDL-C individuals, 373 European ancestry low HDL-C individuals
Crohn's disease and psoriasis
2,529 European ancestry psoriasis cases, 2,142 European ancestry Crohn's disease cases, 10,460 European ancestry controls
Up to 3,187 European ancestry psoriasis cases, 4,073 European ancestry Crohn's disease cases, 10,100 European ancestry controls
Affymetrix, Illumina, Perlegen [1116213] (imputed)
1,193 European ancestry cases, 1,190 European ancestry controls
2,974 European ancestry cases, 3,012 European ancestry controls
Treatment response for severe sepsis
1,446 individuals
7,861 African American individuals, 3,425 Hispanic individuals
7,138 African American individuals
7,601 African American individuals, 3,335 Hispanic individuals
7,917 African American individuals, 3,506 Hispanic individuals
302 European ancestry female cases, 321 European ancestry female controls
1,153 European ancestry female cases, 1,215 European ancestry female controls
Nephrolithiasis
80 Sardinian cases, 94 Sardinian controls
125 European ancestry cases, 157 European ancestry controls
141 Russian ancestry cases, 120 Tatar ancestry cases, 69 Bashkir ancestry cases, 145 Russian ancestry controls, 111 Tatar ancestry controls, 92 Bashkir ancestry controls
202 Russian, Tatar, and Bashkir ancestry cases, 109 Russian ancestry controls, 54 Tatar ancestry controls, 53 Bashkir ancestry controls
230 Han Chinese ancestry cases, 230 Han Chinese ancestry controls
3,240 Han Chinese ancestry cases, 4,353 Han Chinese ancestry controls
Immune response to smallpox vaccine (IL-6)
217 African American individuals, 580 European ancestry individuals, 217 Hispanic individuals
Parkinson's disease (motor and cognition)
443 European ancestry cases
190 European ancestry schizophrenia cases, 157 European ancestry bipolar disorder cases, 353 European ancestry controls
20,427 African ancestry individuals
Up to 16,436 African American individuals
Affymetrix, Illumina [3310998] (imputed)
Thyrotoxic hypokalemic periodic paralysis
78 Thai ancestry cases, 74 Thai ancestry controls
28 Thai ancestry cases, 48 Thai ancestry controls
391 Han Chinese ancestry cases, 895 Han Chinese ancestry controls
400 Han Chinese ancestry cases, 800 Han Chinese ancestry controls
319 European ancestry cases, 3,462 European ancestry controls
615 European ancestry cases, 702 European ancestry controls
495 European ancestry child and adolescent cases, 1,300 European ancestry adult controls
1,023 European ancestry individuals from 320 families, 2455 European ancestry cases and 896 European ancestry controls from 2,064 trios
341 ADHD case offspring from 339 trios
882 Sardinian cases, 872 Sardinian controls
1,775 Sardinian cases, 2,005 Sardinian controls
8,651 African American individuals
1,996 African American individuals
237 European ancestry female cases, 2,287 European ancestry female controls
Bulimia nervosa
151 European ancestry female cases, 2,291 European ancestry female controls
Eating disorders (purging via substances)
600 European ancestry female cases, 1,921 European ancestry female controls
543 European ancestry female cases, 1,116 European ancestry female controls
2,782 European ancestry cases, 4,458 European ancestry controls
7,358 European ancestry cases, 6,732 European ancestry controls
D-dimer levels
21,052 European ancestry individuals
Affymetrix, Illumina [2522393] (imputed)
1,114 European ancestry twins
5,294 European ancestry twins
2,112 lean type 2 diabetes cases, 4,123 obese type 2 diabetes cases, 54,412 controls
2,881 lean type 2 diabetes cases, 8,702 obese type 2 diabetes cases, 18,957 controls
Erectile dysfunction in type 1 diabetes
125 European ancestry cases, 403 European ancestry controls
1,949 Middle Eastern ancestry individuals
2,547 Middle Eastern ancestry individuals
620 European ancestry never smoker cases
1,256 Chinese ancestry never smoker cases
904 European ancestry individuals
1,972 European ancestry individuals from 593 families, 761 European ancestry individuals, 2,955 Han Chinese ancestry individuals
Response to iloperidone treatment (PANSS-T score)
106 Asian, African American, European, or other ancestry individuals
104 Asian, African American, European, or other ancestry individuals
2,157 European ancestry cases, 1,150 European ancestry controls
7,892 European ancestry cases, 5,998 European ancestry controls, 678 Japanese ancestry cases, 336 Japanese ancestry controls
5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls
13,170 South Asian ancestry cases, 25,398 South Asian ancestry controls
Parkinson's disease (coffee consumption interaction)
1,458 European ancestry cases, 931 European ancestry controls
1,014 European ancestry cases, 1,917 European ancestry controls
69 Chinese ancestry cases, 1,170 East Asian ancestry controls
54 Chinese ancestry cases, 400 Taiwanese ancestry controls
Response to iloperidone treatment (QT prolongation)
91 African American Schizophrenia cases, 69 European ancestry Schizophrenia cases, 16 Asian ancestry Schizophrenia cases, 7 Schizophrenia cases
Homeostasis model assessment of beta-cell function (dietary factor interaction)
Fasting insulin (dietary factor interaction)
Homeostasis model assessment of insulin resistance (dietary factor interaction)
Liver enzyme levels (aspartate transaminase)
Orthostatic hypotension
667 Korean ancestry cases, 5,761 Korean ancestry controls
866 Old Order Amish individuals
Acne (severe teenage)
81 European ancestry cases, 847 European ancestry controls
134 European ancestry cases, 1,258 European ancestry controls
3,769 European ancestry cases, 4,396 European ancestry controls
211 East Asian ancestry cases, 972 East Asian ancestry controls, 39,674 European ancestry individuals, 106 Malaysian ancestry cases, 106 Malaysian ancestry controls
Hippocampal volume in schizophrenia
170 European ancestry individuals, 158 individuals
2,020 European ancestry cases, 7,438 European ancestry controls
Gaucher disease severity
139 Ashkenazi Jewish cases
2,062 East Asian ancestry cases, 2,066 East Asian ancestry controls
15,091 East Asian ancestry cases, 14,877 East Asian ancestry controls
9,049 European ancestry individuals
1,283 European ancestry cases, ~20,000 European ancestry controls
3,119 European ancestry cases, 11,146 European ancestry controls
4,501 European ancestry cases, 6,076 European ancestry controls
1,382 European ancestry cases, 2,201 European ancestry controls
6,307 European ancestry individuals
1,715 African American individuals
3,274 African American individuals
1,120 Pima Indian ancestry individuals
2,133 Pima Indian ancestry individuals
2,633 European ancestry extremely obese adult cases, 2,740 European ancestry controls
29,181 European ancestry individuals
536 European ancestry early-onset cases
1,516 European ancestry early-onset cases
Butyrylcholinesterase levels
6,879 European ancestry adult individuals
1,260 European ancestry adult individuals, 652 European ancestry adolescent individuals
5,006 European ancestry individuals
1,124 European ancestry individuals, 3,764 individuals
39 European ancestry severe statin myopathy cases, 40 European ancestry controls
67 European ancestry severe statin myopathy cases, 42 European ancestry controls
5,122 European ancestry female migrain cases
8,866 European ancestry individuals
Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid)
Tardive dyskinesia
61 Japanese ancestry schizophrenic cases, 61 Japanese ancestry cases schizophrenic controls
36 Japanese ancestry schizophrenic cases, 138 Japanese ancestry schizophrenic controls
3,736 European ancestry cases, 35,546 European ancestry controls
1,241 European ancestry female individuals
Bone mineral density (sex interaction)
16,297 European ancestry female individuals, 9,056 European ancestry male individuals
17,949 European, East Asian, and Hispanic ancestry female individuals, 6,814 European, East Asian, and Hispanic ancestry male individuals
590 European ancestry cases, 3,956 European ancestry controls
892 European ancestry advanced cases, 4,582 European ancestry less severe cases
573 European ancestry children
107 European ancestry children, 591 Hispanic children, 233 children
2,637 European ancestry cases, 7,927 European ancestry controls
2,431 European ancestry cases, 3,673 European ancestry controls
3,332 European ancestry cases, 3,228 European ancestry controls
Affymetrix, Illumina [1251157] (imputed)
Up to 666 European ancestry trios, 399 European ancestry cases, 1,318 European ancestry controls
up to 795 East Asian ancestry trios
3,268 European ancestry cases, 3,366 European ancestry controls
12,526 European ancestry individuals
Immune reponse to smallpox (secreted IL-12p40)
Up to 512 European ancestry individuals, up to 199 African American individuals
Immune reponse to smallpox (secreted IL-2)
Immune reponse to smallpox (secreted IL-10)
Immune reponse to smallpox (secreted IL-1beta)
Up to 512 European ancestry individuals, 199 African American individuals
Immune reponse to smallpox (secreted TNF-alpha)
Immune reponse to smallpox (secreted IFN-alpha)
Sclerosing cholangitis and ulcerative colitis (combined)
Up to 389 European ancestry primary sclerosing cholangitis cases, 987 European ancestry ulcerative colitis cases, 2,968 European ancestry controls
1,012 European ancestry primary sclerosing cholangitis cases, 4,444 European ancestry ulcerative colitis cases, 11,659 European ancestry controls
Psychosis
1,239 European ancestry cases, 3,596 European ancestry control
10,352 cases, 24,474 controls
909 European ancestry cases, 2,120 European ancestry controls
3,234 European ancestry cases, 5,590 European ancestry controls
6,523 European ancestry individuals
4,442 European ancestry individuals
1,200 European ancestry cases, 6,417 European ancestry controls
563 European ancestry cases, 613 European ancestry controls
5,823 African American individuals
9,992 European ancestry individuals
Affymetrix, Illumina [up to 2727966] (imputed)
805 European ancestry cases, 805 European ancestry controls
Response to mTOR inhibitor (everolimus)
87 European ancestry individuals, 91 African American individuals, 94 Han Chinese ancestry individuals
Response to mTOR inhibitor (rapamycin)
8,323 European ancestry cases, 9,457 European ancestry controls
19,513 European ancestry cases, 17,657 European ancestry controls, 1,583 Japanese ancestry cases, 1,898 Japanese ancestry controls
142 European ancestry female twins
202 European ancestry individuals
715 Mexican American individuals
387 European ancestry cases, 5,380 European ancestry controls
294 European ancestry cases, 50 European ancestry controls
1,015 European ancestry individuals, 541 African American individuals
End-stage renal disease (non-diabetic)
464 African American cases, 478 African American controls
336 African American cases, 363 African American controls
Up to 1,054 European ancestry cases, 3,278 European ancestry controls
1,624 European ancestry individuals
1,470 European ancestry cases, 1,932 European ancestry controls
515 African American cases
590 European ancestry cases, 825 European ancestry controls
1,944 Han Chinese ancestry progressed cases, 854 Han Chinese ancestry asymptomatic carriers
404 cases
108 Abstinent individuals , 216 Non-abstinent individuals
100 Korean ancestry cases, 600 Korean ancestry controls
578 Korean ancestry cases, 711 Korean ancestry controls
1,305 European ancestry children
1,695 European ancestry children
1,329 African ancestry cases, 1,847 African ancestry controls
2,024 African ancestry cases, 5,154 African ancestry controls, 1,025 Indonesian ancestry cases, 983 Indonesian ancestry controls, 4,441 European ancestry cases, 5,874 European ancestry controls
Multiple myeloma (hyperdiploidy)
up to 1,660 European ancestry cases, 7,306 European ancestry controls
Multiple myeloma (IgH translocation)
756 Mongolian ancestry individuals from 55 families
1,301 Korean ancestry individuals
Anticoagulant levels
397 European ancestry individuals from 21 families
133,653 European ancestry individuals
50,074 European ancestry individuals
Affymetrix, Illumina [2834208] (imputed)
353 European ancestry cases, 366 European ancestry controls
991 African Americans, 4,308 European ancestry cases, 9,661 European ancestry controls
8,309 European ancestry cases, 7,366 European ancestry controls
10,523 European ancestry cases, 28,231 European ancestry controls
Affymetrix, Illumina [2324889] (imputed)
5,088 European ancestry individuals
18,436 European ancestry individuals
Tetralogy of Fallot
835 European ancestry cases, 5,159 European ancestry controls
798 European ancestry cases, 2,931 European ancestry controls
6,345 European ancestry female individuals
904 Japanese ancestry cases, 7,471 Japanese ancestry controls
4,892 Japanese ancestry cases, 9,873 Japanese ancestry controls
1,409 European ancestry cases, 1,518 European ancestry controls, 681 African American cases, 508 African American controls
5,487 European ancestry individuals
1,442 African American individuals, 1,399 Hispanic individuals, 761 Chinese ancestry individuals
1,313 Bangladeshi ancestry individuals
12,475 European ancestry cases, 19,967 European ancestry controls
3,322 European ancestry cases, 22,036 European ancestry controls
Response to irinotecan in non-small-cell lung cancer
101 non-small-cell lung cancer cases
146 non-small-cell lung cancer cases
22,100 European ancestry individuals
Affymetrix, Illumina [2800000] (imputed)
Adverse response to lamotrigine and phenytoin
34 European ancestry lamotrigine-induced hypersensitivity cases, 42 European ancestry phenytoin-induced hypersensitivity cases, 1,296 European ancestry controls
9,934 European ancestry cases, 16,956 European ancestry controls
1,120 European ancestry affected trios
Affymetrix, Illumina [~ 2540000] (imputed)
2,784 European ancestry individuals
188 Bulgarian ancestry cases, 376 Bulgarian ancestry controls
122 Bulgarian ancestry cases, 328 Bulgarian ancestry controls
2,693 European ancestry cases, 6,791 European ancestry controls
2,009 European ancestry cases, 1,580 European ancestry controls
Eosinophilic esophagitis (pediatric)
181 European ancestry cases, 1,974 European ancestry controls
170 European ancestry cases, 1,130 European ancestry controls
22 European ancestry cases, 76 European ancestry controls, 21 African ancestry cases, 86 African ancestry controls
84 European ancestry cases, 267 European ancestry controls, 15 African ancestry cases, 32 African ancestry controls
96 colon cancer cases
247 colon cancer cases
9,394 European ancestry cases, 12,462 European ancestry controls
8,442 European ancestry cases, 21,397 European ancestry controls
Affymetrix, Illumina [1252901] (imputed)
15,279 European ancestry individuals
up to 7,604 European ancestry individuals
Affymetrix, Illumina [2729294] (imputed)
Factor VII levels
15,422 European ancestry individuals
Affymetrix, Illumina [2734954] (imputed)
17,596 European ancestry individuals
Affymetrix, Illumina [2742821] (imputed)
Cleft lip
825 European ancestry trios, 1,038 Asian ancestry trios
2,194 Asian ancestry family members, 322 South Asian ancestry family members, 3,830 European ancestry family members, 1,769 South and Central American ancestry family members
4,048 European ancestry cases
1,772 European ancestry cases, 4,733 cases
1,000 Han Chinese ancestry cases, 1,000 Han Chinese ancestry controls
409 Han Chinese ancestry cases, 1,000 Han Chinese ancestry controls
1,658 European ancestry cases, 1,655 European ancestry controls
5,995 European ancestry cases, 5,902 European ancestry controls, 455 European ancestry individuals, 1,142 African American cases, 985 African American controls
783 European ancestry cases, 3,001 European ancestry controls
307 European ancestry cases, 2,587 European ancestry controls
1,117 Han Chinese ancestry cases, 1,701 Han Chinese ancestry controls
5,740 Han Chinese ancestry cases, 10,324 Han Chinese ancestry controls
Chemotherapeutic susceptibility
83 African American lymphoblastoid cell lines, 176 African ancestry lymphoblastoid cell lines
Plasminogen activator inhibitor type 1 levels (PAI-1)
19,599 European ancestry individuals
10,764 European ancestry individuals
Affymetrix, Illumina [2445683] (imputed)
1,335 European ancestry cases, 12,844 European ancestry controls
1,164 European ancestry cases, 3,607 European ancestry controls
Cannabis dependence
708 African American or European ancestry cases, 2,346 African American or European ancestry controls
Up to 2,165 European, African American, East Asian and South Asian ancestry individuals
Up to 1,231 individuals
Hepatitis C induced liver fibrosis
1,161 European ancestry HCV-infected individuals
1,181 European ancestry HCV-infected individuals
1,527 European ancestry cases, 3,421 European ancestry controls,
21,791 European ancestry individuals
555 European ancestry individuals
2,215 European ancestry cases, 8,566 European ancestry controls
3,739 European ancestry cases, 8,786 European ancestry controls
Pancreatitis
676 European ancestry cases, 4,507 European ancestry controls
910 European ancestry cases, 4,170 European ancestry controls
Lipoprotein diameter
2,430 European ancestry individuals, 1,594 African American individuals, 1,422 Hispanic individuals, 758 Chinese ancestry individuals
5,510 East Asian ancestry cases, 4,544 East Asian ancestry controls
1,099 East Asian ancestry cases, 2,913 East Asian ancestry controls
366 Japanese ancestry cases, 3,331 Japanese ancestry controls
1,628 East Asian ancestry cases, 17,469 East Asian ancestry controls, 399 European ancestry cases, 5,035 European ancestry control
8,463 European ancestry individuals, 7,478 African American individuals, 3,348 Hispanic individuals, 1,624 Han Chinese ancestry individuals
4,979 European ancestry individuals, 2,740 Han Chinese ancestry individuals
Affymetrix, Illumina [4325550] (imputed)
Fat body mass
6,433 European ancestry individuals, 709 African American individuals, 408 Hispanic individuals, 1,622 Han Chinese ancestry individuals
4,967 European ancestry individuals, 2,740 Han Chinese ancestry individuals
Up to 16,485 African American individuals
9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals
Systolic blood pressure in sickle cell anemia
1617 African American cases
1,773 East Asian ancestry cases, 2,642 East Asian ancestry controls
6,902 East Asian ancestry cases, 7,862 East Asian ancestry controls
Affymetrix, Illumina [1695815] (imputed)
2,259 European ancestry cases, 6,017 European ancestry controls
2,585 European ancestry cases, 4,491 European ancestry controls, 4,039 cases, 6,736 controls
97 European ancestry cases, 93 European ancestry controls
63 European ancestry cases, 79 European ancestry controls
2,632 Han Chinese ancestry individuals
3,917 Han Chinese ancestry individuals, 696 European ancestry individuals
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy)
40 European ancestry cases, 37 African American cases, 13 Hispanic cases, 85 European ancestry controls, 49 African American controls, 30 Hispanic controls
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy)
8 European ancestry cases, 12 African American cases, 3 Hispanic cases, 85 European ancestry controls, 49 African American controls, 30 Hispanic controls
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy)
19 European ancestry cases, 30 African American cases, 9 Hispanic cases, 85 European ancestry controls, 49 African American controls, 30 Hispanic controls
981 European ancestry cases, 1,002 European ancestry controls
10,287 European ancestry cases, 10,401 European ancestry controls, 4,400 Japanese ancestry cases, 3,179 Japanese ancestry controls, 1,789 cases, 1,771 controls
Plasma cystastin c levels in acute coronary syndrome
9,801 European ancestry cases, 57 Black cases, 90 Oriental ancestry cases, 30 cases
19,509 European ancestry individuals
11,823 European ancestry individuals
6,100 European ancestry cases, 7,125 European ancestry controls
2,074 European ancestry cases, 2,556 European ancestry controls
Rate of change of FEV1 (time interaction)
up to 27,249 European ancestry individuals
1,494 individuals, 4,084 mild chronic obstructive pulmonary disease smoker individuals
1,827 Korean ancestry females
3,437 Korean ancestry females
4,840 European ancestry cases, 2,670 European ancestry controls, 5,766 European ancestry familial triads
417 European ancestry cases, 411 European ancestry controls, 217 African American cases, 219 African American controls, 104 American Indian, Asian, Pacific Islander or Hispanic/Latino ancestry cases, 103 American Indian, Asian, Pacific Islander or Hispanic/Latino ancestry controls
3,417 European ancestry individuals
1,893 African American and European ancestry individuals, 2,876 European ancestry individuals
542 Han Chinese ancestry cases, 1,050 Han Chinese ancestry controls
1,303 Han Chinese ancestry cases, 2,727 Han Chinese ancestry controls
1563 European ancestry cases, 4,054 European ancestry controls
2,286 European ancestry cases, 3,160 European ancestry controls
1,086 Japanese ancestry males
1,302 Japanese ancestry males
1,678 European ancestry individuals
3,034 European ancestry cases, 5,271 European ancestry controls
4,726 European ancestry cases, 2,625 European ancestry controls
Affymetrix, Illumina [1831729] (imputed)
Hereditary hemochromatosis-related traits (HFE mutation homozygotes)
474 European ancestry cases
746 European ancestry cases
692 European ancestry cases, 1,001 European ancestry controls
256 European ancestry cases, 488 European ancestry controls
743 African American individuals, 1,188 Nigerian ancestry individuals
704 African American individuals from 306 families, 3,471 African American and Afro-Caribbean individuals
562 European ancestry cases, 702 European ancestry controls
370 cases, 495 controls
582 European ancestry male cases, 1,056 European ancestry male controls
3,560 European ancestry male cases, 8,510 European ancestry male controls
Mitral annular calcification
3,795 European ancestry individuals
745 European ancestry individuals, 2,497 African American individuals, 2,027 Hispanic individuals, 774 Chinese ancestry individuals
Affymetrix, Illumina [> 2500000] (imputed)
Aortic-valve calcification
6,942 European ancestry individuals
Meningococcal disease
475 European ancestry cases, 4,703 European ancestry controls
929 European ancestry cases, 1,351 European ancestry controls
367 European ancestry individuals with mild cognitive impairment, 181 European ancestry individuals with mild early-stage LOAD, 209 European ancestry controls
529 Japanese ancestry cases, 932 Japanese ancestry controls
Depression and alcohol dependence
467 European ancestry cases, 407 European ancestry controls
7,123 European ancestry cases, 6,826 European ancestry controls
5,211 European ancestry cases, 5,821 European ancestry controls
288 Japanese ancestry cases, 194 Japanese ancestry controls
739 Japanese ancestry cases, 659 Japanese ancestry controls
24 cases, 24 controls
98 cases, 218 controls
Platelet function and related traits
70 children
286 children
1,999 Han Chinese ancestry males
1,496 East Asian ancestry males
Waist-to-hip circumference ratio (ever vs never smoking interaction)
8,203 African American females, 3,484 Hispanic females
Body mass index (alcohol intake interaction)
Body mass index (dietary energy interaction)
Body mass index (recreational physical activity interaction)
Body mass index (ever vs never smoking interaction)
Body mass index (smoking years interaction)
Waist-to-hip circumference ratio (dietary energy interaction)
Waist-to-hip circumference ratio (smoking years interaction)
Waist-to-hip circumference ratio (recreational physical activity interaction)
Waist-to-hip circumference ratio (alcohol intake interaction)
Occipital cortical area (total cortical area interaction)
421 European ancestry individuals
760 European ancestry individuals
155 Jewish-Israeli ancestry cases and 176 Jewish-Israeli ancestry controls from 107 families
99 Arab-Israeli ancestry cases and 99 Arab-Israeli ancestry controls from 57 families
814 European ancestry cases, 658 European ancestry controls, 2,400 controls
1,744 European ancestry cases, 7,010 European ancestry controls
98 Chinese ancestry cases, 60 Chinese ancestry controls
Postoperative nausea and vomiting
122 European ancestry cases, 129 European ancestry controls
104 European ancestry cases, 104 European ancestry controls
3,554 European ancestry individuals
2,460 European ancestry individuals
Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer
139 individuals
Job-related exhaustion
1,256 European ancestry individuals
13,864 European ancestry individuals
Thyroid volume
3,620 European ancestry individuals
349 European ancestry cases, 919 European ancestry controls
439 European ancestry cases, 960 European ancestry controls
16,264 European ancestry individuals
5,444 individuals
Up to 23,564 African American individuals
Up to 10,027 African American individuals
Affymetrix, Illumina [3200000] (imputed)
up to 19,744 African American individuals
Up to 7,606 African American individuals
1,040 Han Chinese ancestry cases, 963 Han Chinese ancestry controls
2,642 Japanese ancestry cases, 2,099 Japanese ancestry controls
2,885 Japanese ancestry cases, 3,395 Japanese ancestry controls
Borderline personality disorder features
up to 7,125 individuals
1,301 individuals
419 European ancestry ETV6-RUNX1 positive cases, 474 European ancestry controls
951 European ancestry ETV6-RUNX1 positive cases, 326 European ancestry ETV6-RUNX1 negative cases, 3,061 European ancestry controls
1,012 Han Chinese ancestry cases, 1,362 Han Chinese ancestry controls
3,624 Han Chinese ancestry cases, 12,197 Han Chinese ancestry controls, 1,806 European ancestry cases, 3,256 European ancestry controls
3,527 European ancestry individuals
1,727 European ancestry individuals
Odorant perception
1,573 European ancestry young-adult twins and singleton siblings
200 European ancestry adult monozygous twin individuals, 26 European ancestry adult dizygous twin individuals
Blood pressure measurement (cold pressor test)
1,881 Han Chinese ancestry individuals
698 Han Chinese ancestry individuals
Blood pressure measurement (high sodium and potassium intervention)
1,836 Han Chinese ancestry individuals
654 Han Chinese ancestry individuals
Blood pressure measurement (low sodium intervention)
1,850 Han Chinese ancestry individuals
660 Han Chinese ancestry individuals
Blood pressure measurement (high sodium intervention)
1,840 Han Chinese ancestry individuals
659 Han Chinese ancestry individuals
348 Chinese ancestry cases, 359 Chinese ancestry controls
2,121 Chinese ancestry cases, 1,748 Chinese ancestry controls
429 European ancestry affected offspring trios
52 African American affected offspring trios, 46 Hispanic affected offspring trios
Malignant mesothelioma
428 European ancestry cases, 2,047 European ancestry controls
463 European ancestry cases, 1,197 European ancestry controls
5,999 East Asian ancestry cases, 9,001 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls
18,127 East Asian ancestry cases, 17,746 East Asian ancestry controls
Affymetrix, Illumina [2626356] (imputed)
Self-reported allergy
53,862 European ancestry individuals
8,938 European ancestry male individuals
5,491 European ancestry male individuals
5,539 European ancestry cases, 20,169 European ancestry controls
6,768 European ancestry cases, 8,806 European ancestry controls
Affymetrix, Illumina [~ 2716259] (imputed)
Fluorouracil treatment response in colorectal cancer
203 European ancestry cases
791 European ancestry cases
1,870 European ancestry individuals
3,745 European ancestry individuals
Amygdala reactivity
224 European ancestry individuals
50 European ancestry individuals, 13 African American individuals, 29 Asian ancestry individuals, 7 individuals
973 European ancestry cases, 144 European ancestry controls
Schizophrenia (age at onset)
1,162 European ancestry cases
1,068 European ancestry cases
Schizophrenia (age at onset) (sex interaction)
9,361 European ancestry individuals
3,024 European ancestry individuals
Affymetrix, Illumina [2153274] (imputed)
146 East Asian ancestry cases, 374 East Asian ancestry controls
900 European ancestry female individuals with low hip bone mineral density, 1,055 European ancestry female individuals with high hip bone mineral density
20,898 European ancestry female individuals
222 European ancestry cases, 3,324 European ancestry controls
304 European ancestry cases, 518 European ancestry controls, 146 European ancestry cases and 161 European ancestry controls from 70 families
2,008 Chinese ancestry inidividuals, 2,281 Malay ancestry individuals
2,142 Asian Indian ancestry individuals, 929 Chinese ancestry children
Postoperative ventricular dysfunction
76 European ancestry male cases, 1,123 European ancestry controls
188 European ancestry male cases, 1,200 European ancestry male controls
2,185 European ancestry adolescent individuals
1,622 European ancestry adolescent individuals
7,481 European ancestry cases, 9,250 European ancestry controls
4,496 European ancestry cases, 42,422 European ancestry controls
Affymetrix, Illumina [2415422] (imputed)
Glycemic traits
7,696 Korean ancestry individuals
6,536 Korean ancestry individuals
1,788 European ancestry twins and family members, 1,013 European ancestry unrelated individuals
Vaspin levels
1806 European ancestry individuals
Chronic myeloid leukemia
201 Korean ancestry cases, 497 Korean ancestry controls
237 Korean ancestry cases, 1,000 Korean ancestry controls, 232 European ancestry cases, 576 European ancestry controls
Epilepsy (remission after treatment)
889 European and unknown ancestry epilepsy cases
3,666 European ancestry cases, 28,864 European ancestry controls, 1,004 African American cases, 2,744 African American controls
562 European ancestry cases, 6,410 European ancestry controls, 84 Japanese ancestry cases, 830 Japanese ancestry controls, 300 Latino cases, 1,164 Latino controls
190 Japanese ancestry cases, 1,557 Japanese ancestry controls
2,089 Japanese ancestry cases, 3,114 Japanese ancestry controls
Joint damage progression in ACPA-positive rheumatoid arthritis
384 cases
301 European ancestry cases, 742 cases
2,064 European ancestry trios, 896 European ancestry cases, 2,455 European ancestry controls
Affymetrix, Illumina, Perlegen [1206462] (imputed)
6,649 European ancestry children and adolescents
Reading and spelling
Non-word repetition
7,107 European ancestry cases, 69,427 European ancestry controls
5,118 European ancestry cases, 74,239 European ancestry controls
23,285 European ancestry cases, 95,425 European ancestry controls
Migraine - clinic-based
5,175 European ancestry clinic-based cases, 13,972 European ancestry clinic-based controls
1,804 Hispanic cases, 780 Hispanic controls
European ancestry individuals
187 European ancestry child cases, 244 European ancestry cases, 4,980 European ancestry controls
Ventricular fibrillation
Up to 515 European ancestry cases, 457 European ancestry controls
146 European ancestry cases, 391 European ancestry controls
202 European ancestry more aggressive cases, 100 European ancestry controls
527 European ancestry more aggressive cases, 595 European ancestry less aggressive cases, 1,167 European ancestry controls
Colorectal cancer (SNP x SNP interaction)
8,380 European ancestry cases, 10,558 European ancestry controls
2,527 European ancestry cases, 2,628 European ancestry controls
405 European ancestry cases, 6,252 European ancestry controls
605 European ancestry cases and 1,349 European ancestry controls from 740 families, 135 cases and 270 controls from 135 families, 1,028 East Asian ancestry cases, 1,512 East Asian ancestry controls
26,620 Japanese ancestry individuals
35,625 East Asian ancestry individuals
Response to platinum-based chemotherapy (carboplatin)
176 Sub-Saharan African ancestry lymphoblastoid cell lines, 83 African ancestry lymphoblastoid cell lines, 175 East Asian ancestry lymphoblastoid cell lines, 174 European ancestry lymphoblastoid cell lines
Response to platinum-based chemotherapy (cisplatin)
Bipolar disorder (mania)
117 European ancestry Irritable mania cases, 843 European ancestry Elated mania cases, 1033 European ancestry controls
121 European ancestry Irritable maniacases, 1026 European ancestry Elated mania cases
1,004 African American cases, 2,745 African American controls,1,718 European ancestry cases, 3,670 European ancestry controls
2,292 European ancestry cases, 16,901 European ancestry controls
Electrodermal activity
Up to 4,424 European ancestry twins and their parents
34,379 European ancestry cases, 33,164 European ancestry controls, 5,327 African ancestry cases, 5,136 African ancestry controls, 2,563 Japanese ancestry cases, 4,391 Japanese ancestry controls, 1,034 Latino cases, 1,046 Latino controls
Affymetrix, Illumina [up to 16852405] (imputed)
958 European ancestry obese cases, 955 European ancestry non-obese cases, 2,938 European ancestry controls
Up to 3,757 European ancestry cases, up to 5,346 European ancestry controls
5,095 European ancestry cases, 5,200 European ancestry controls
2,448 European ancestry cases, 2,983 European ancestry controls
End-stage renal disease or diabetic nephropathy in type 1 diabetes
661 European ancestry End-stage renal disease cases, 694 European ancestry Diabetic nephropathy cases, 472 European ancestry Microalbuminuria cases, 1,637 European ancestry controls
92 End-stage renal disease cases, 345 Diabetic nephropathy cases, 135 Microalbuminuria cases, 370 controls
Diabetic nephropathy in type 1 diabetes
683 European ancestry cases, 779 European ancestry controls
2,962 European ancestry cases, 3,379 European ancestry controls
Hashimoto thyroiditis versus Graves' disease
263 Japanese ancestry Hashimoto thyroiditis cases, 260 Japanese ancestry Graves’ disease cases
181 Japanese ancestry Hashimoto thyroiditis cases, 286 Japanese ancestry Graves’ disease cases
Urinary metabolites (H-NMR features)
601 Brazilian individuals
36,227 East Asian ancestry individuals
57,699 East Asian ancestry individuals
Affymetrix, Illumina [2704730] (imputed)
Esophageal squamous cell carcinoma
5,337 Han Chinese ancestry cases, 5,787 Han Chinese ancestry controls
9,654 Han Chinese ancestry cases, 10,058 Han Chinese ancestry controls
Affymetrix, Illumina [7556215] (imputed)
Marginal zone lymphoma
825 European ancestry cases, 6,221 European ancestry controls
456 European ancestry cases, 906 European ancestry controls
Fasting plasma glucose (childhood)
776 Korean ancestry children
86,142 European ancestry female individuals, 557 Old Order Amish (founder/genetic isolate) female individuals, 1,103 Erasmus Rucphen (founder/genetic isolate) female individuals
Up to 12,813 European ancestry female individuals, 910 Val Borbera (founder/genetic isolate) female individuals, 348 Orcadian (founder/genetic isolate) female individuals, 338 Friuli Venezia Giulia (founder/genetic isolate) female individuals, 322 Carlantino (founder/genetic/isolate) female individuals
Phenytoin-induced severe cutaneous adverse reactions
60 Han Chinese ancestry cases, 412 Han Chinese ancestry controls
39 East Asian ancestry cases, 130 Han Chinese ancestry phenytoin-tolerant controls, 2,869 Japanese ancestry controls, 6 Asian ancestry cases, 374 Asian ancestry controls
2,790 Black individuals
Coronary artery calcification (smoking interaction)
915 European ancestry individuals
1,025 European ancestry individuals
13,582 European ancestry individuals
6,291 European ancestry individuals
Contrast sensitivity
985 European ancestry individuals
Schizophrenia, schizoaffective disorder or bipolar disorder
11,985 European, African American, Asian, other and unknown ancestry schizophrenia cases, 377 European, African American, Asian, other and unknown ancestry schizoaffective disorder cases, 1,032 bipolar disorder cases, 34,676 European, African American, Asian, other and unknown ancestry controls
2652 individuals
Social communication problems
Up to 5,628 European ancestry individuals
Congenital heart disease
1,479 European ancestry congenital heart disease cases, 340 European ancestry ostium secundum atrial septal defect cases, 5,159 European ancestry controls
417 European ancestry ostium secundum atrial septal defect cases, 209 European ancestry ventricular septal defect cases, 2,520 European ancestry controls
Response to antidepressant treatment (citalopram)
869 European, Hispanic, African American, Asian, mixed race and other ancestry sustained response individuals, 247 European, Hispanic, African American, Asian, mixed race and other ancestry unsustained response individuals
394 European ancestry sustained response individuals, 191 European ancestry unsustained response individuals
Tooth agenesis (mandibular third molar)
80 East Asian ancestry mandibular cases, 69 East Asian ancestry maxillary cases, 338 East Asian ancestry controls
Tooth agenesis (third molar)
149 East Asian ancestry cases, 338 East Asian ancestry controls
Tooth agenesis (maxillary third molar)
125 East Asian ancestry maxillary cases, 24 East Asian ancestry mandibular cases, 338 East Asian ancestry controls
940 European, Hispanic, Native American, African American, East Asian and other ancestry cases, 2,554 European, Hispanic, Native American, African American, East Asian and other ancestry trauma-exposed controls
313 European ancestry cases, 178 European ancestry trauma-exposed controls
35,812 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 2557249] (imputed)
Urinary uromodulin levels
10,884 European ancestry individuals
Response to haloperidol in psychosis
96 European ancestry cases
Bone properties (heel)
730 East Asian ancestry individuals, 2,380 European ancestry individuals, 11,150 individuals
11,058 European ancestry individuals, 2,870 European and other ancestry individuals, 21,439 individuals
Affymetrix, Illumina [up to 2609590] (imputed)
4,556 European ancestry individuals
2,236 European ancestry individuals
Affymetrix, Illumina [up to 2399195] (imputed)
2,483 East Asian ancestry individuals, 1,885 European ancestry individuals, 11,146 individuals
10,074 European ancestry individuals, 2,870 European and other ancestry individuals, 21,434 individuals
6,085 Korean ancestry individuals
7,295 Japanese ancestry individuals
Migraine in bipolar disorder
460 European ancestry cases with migraine, 914 European ancestry cases without migraine
289 European ancestry cases with migraine, 697 European ancestry without migraine
Bipolar disorder with mood-incongruent psychosis
2,196 European and other ancestry cases, 8,148 European and other ancestry controls
724 European ancestry individuals
439 European ancestry individuals
Sensory disturbances after bilateral sagittal split ramus osteotomy
Up to 105 individuals
Up to 200 individuals
Reading or mathematical ability
up to 2,794 European ancestry unrelated members of twin pairs
2,153 European ancestry individuals
102 Han Chinese ancestry cases, 212 Han Chinese ancestry controls
108 Han Chinese ancestry cases, 190 Han Chinese ancestry controls
272 Han Chinese ancestry individuals
5,584 European ancestry children
1,364 European ancestry children
Substance dependence phenotypes
Seasonality
3,269 European ancestry individuals
887 Old order Amish individuals
Affymetrix, Illumina [2354422] (imputed)
Colorectal cancer (diet interaction)
9,287 European ancestry cases, 9,117 European ancestry controls
Affymetrix, Illumina [> 2700000] (imputed)
976 Korean ancestry cases, 946 Korean ancestry controls
249 Korean ancestry cases, 778 Korean ancestry controls
393 European ancestry cases, 399 European ancestry controls
375 European ancestry trios, 1,395 European ancestry cases, 1,603 European ancestry controls, 454 French Canadian founder trios, 466 French Canadian founder cases, 358 French Canadian founder controls
309 European ancestry cases, 2,925 European ancestry controls
8,284 African American cases, 15,543 African American controls
6,061 African American cases, 5,483 African American controls, 8,130 European ancestry cases, 38,987 European ancestry controls
Affymetrix, Illumina [2579389] (imputed)
Liver disease in chronic hepatitis B virus infection
up to 305 Arab ancestry cases, 343 Arab ancestry controls
48 Arab ancestry cases, 177 Arab ancestry controls
382 French Canadian founder trios
750 European ancestry cases, 828 European ancestry controls, 521 European ancestry trios
NHDL cholesterol levels
843 Old Order Amish individuals, 2,470 European ancestry individuals
94,595 European ancestry individuals
93,982 European ancestry individuals
up to 4,420 African ancestry individuals
8,743 East Asian ancestry individuals
5,425 African ancestry cases, 6,891 African ancestry controls
2,847 European ancestry primary open angle glaucoma cases, 3,389 European ancestry controls
3,701 Mexican ancestry individuals
5,114 Mexican ancestry individuals, 903 Mexican ancestry individuals from 73 dyslipidemic families
1,678 Mexican ancestry high triglyceride cases, 1,645 Mexican ancestry low triglyceride controls
2,129 Mexican ancestry high triglyceride cases, 2,985 Mexican ancestry low triglyceride controls, 903 Mexican ancestry individuals from 73 dyslipidemic families
Endothelial growth factor levels
up to 3,574 European ancestry individuals
up to 3,184 European ancestry individuals
Response to Dalcetrapib treatment in acute coronary syndrome
2,845 European ancestry individuals
Inflammatory skin disease
2,079 European ancestry atopic dermatitis cases, 4,212 European ancestry psoriasis cases, 11,899 European ancestry controls
2,079 European ancestry cases, 3,867 European ancestry controls
Affymetrix, Illumina, Perlegen [up to 5493100] (imputed)
4,212 European ancestry cases, 8,032 European ancestry controls
Allergic rhinitis in asthma
623 European ancestry cases, 1029 Latino cases, 399 African American/Afro-Caribbean cases, 488 European ancestry controls, 545 Latino controls, 162 African American/Afro-Caribbean controls
Allergic rhinitis in non-asthmatics
249 European ancestry cases, 164 Latino cases, 248 African American/Afro-Caribbean cases, 674 European ancestry controls, 588 Latino controls, 464 African American/Afro-Caribbean controls
872 European ancestry cases, 1,193 Latino cases, 647 African American/Afro-Caribbean cases, 1,162 European ancestry controls, 1,133 Latino controls, 626 African American/Afro-Caribbean controls
3,747 European ancestry individuals, 2,992 individuals,
1,159 European ancestry individuals
Affymetrix, Illumina [up to 2200000] (imputed)
3,742 European ancestry individuals, 2,992 individuals
1,151 European ancestry individuals
3,745 European ancestry individuals, 2,992 individuals
1,152 European ancestry individuals
358 European ancestry cases, 1,192 European ancestry controls
441 European ancestry cases, 1,542 European ancestry controls
Congenital left-sided heart lesions (maternal effect)
284 European ancestry case-parent trios, up to 93 case-parent trios
216 European ancestry case-parent trios, 8 case-parent trios
Congenital left-sided heart lesions
2,016 European ancestry cases, 16,407 European ancestry controls, 173 African ancestry cases, 3,312 African ancestry controls, 41 Hispanic cases, 580 Hispanic controls
966 Han Chinese ancestry cases, 1,005 Han Chinese ancestry controls
1,140 Han Chinese ancestry cases, 2,237 Han Chinese ancestry controls
White matter microstructure (global fractional anisotropy)
727 Mexican American individuals from 65 families, 49 Mexican American individuals
Up to 6,889 individuals
484 European ancestry trauma-exposed individuals
4,368 European ancestry cases, 9,123 European ancestry controls,
2,462 European ancestry BRCA1 mutation carrier cases, 12,790 European ancestry BRCA1 mutation carrier controls, up to 631 European ancestry BRCA2 mutation carrier cases, 7,580 European ancestry BRCA2 mutation carrier controls, 9,627 European ancestry serous cases, 1,442 European ancestry non-serous cases, 21,722 European ancestry controls
123 Korean ancestry cases, 432 Korean ancestry controls
Obstructive sleep apnea
235 Korean ancestry cases, 235 Korean ancestry controls
Red blood cell fatty acid levels
2,633 individuals
Glucose homeostasis traits
up to 4,176 Mexican American individuals
531 Japanese ancestry cases, 5,581 Japanese ancestry conrols
592 Japanese ancestry cases, 6,964 Japanese ancestry controls, 3,508 European ancestry cases, 5,101 European ancestry controls
Superior frontal gyrus grey matter volume
158 Japanese ancestry schizophrenia cases, 378 Japanese ancestry healthy controls
80,067 European ancestry individuals
Affymetrix, Illumina, Perlegen [2550858] (imputed)
1,377 European ancestry behavioural variant cases, 308 European ancestry Semantic dementia cases, 269 European ancestry Progressive nonfluent aphasia cases, 200 European ancestry Frontotremporal dementia with motor neuron disease cases, up to 4,308 European ancestry controls
690 European ancestry behavioural variant cases, 190 European ancestry Semantic dementia cases, 221 European ancestry Progressive nonfluent aphasia cases, 94 European ancestry Frontotremporal dementia with motor neuron disease cases, 177 European ancestry Frontotemporal lobar degeneration cases, up to 5,094 European ancestry controls
39,717 European ancestry individuals, 690 Orcadian individuals
7,170 European ancestry individuals
Conduct disorder (symptom count)
872 European, African American and other ancestry substance dependence cases, 3,091 European, African American and other ancestry controls
Conduct disorder
321 Chinese ancestry cases, 304 Chinese ancestry controls
1,302 Chinese ancestry cases, 761 Chinese ancestry controls
Renal function and chronic kidney disease
2,388 European ancestry cases, 17,489 European ancestry controls
1,932 cases, 19,534 controls
Body mass index (sex interaction)
9,091 European ancestry individuals
2,872 European ancestry individuals
Waist circumference (sex interaction)
Waist-to-hip ratio (sex interaction)
2,698 European ancestry individuals
Plasma trimethylamine N-oxide levels
1,973 European ancestry individuals
1,892 European ancestry individuals
2,329 European ancestry individuals
2,639 European ancestry individuals
6,911 European ancestry cases, 11,818 European ancestry controls
801 cases, 1,307 controls
up to 2,305 European ancestry cases, up to 3,901 European ancestry controls
up to 13,298 cases, up to 54,535 controls
951 Han Chinese ancestry HBV carrier cases, 937 Han Chinese ancestry HBV cleared controls
4,230 Chinese ancestry HBV carrier cases, 3,051 Chinese ancestry HBV cleared controls, 2,622 Chinese ancestry controls
Age-related cataracts
5,503 European, Black, and other ancestry cases age 50 and older, 1,894 European, Black, and other ancestry controls age 50 and older
Age-related cataracts (age at onset)
5,503 European, Black, and other ancestry cases age 50 and older
4,088 European ancestry non-diabetic elderly individuals
up to 47,822 European ancestry non-diabetic elderly individuals
Clubfoot
396 European ancestry cases, 1,000 European ancestry controls
370 European ancestry cases, 363 European ancestry controls
Suicidal ideation in depression or bipolar disorder
237 European ancestry cases, 510 European ancestry controls
Suicide attempts in depression or bipolar disorder
426 European ancestry cases, 2,844 European ancestry controls
1,155 European ancestry cases, 1,922 European ancestry controls
3,548 European ancestry cases, 9,496 European ancestry controls
Serum IgA levels
2,785 European ancestry individuals
CD4:CD8 lymphocyte ratio
2,538 European ancestry twins from 1,089 families
988 individuals from 550 families
CD3-positive T-lymphocyte count
CD4-positive T-lymphocyte count
CD8-positive T-lymphocyte count
CD19-positive B-lymphocyte count
CD56-positive NK-lymphocyte cell count
Autism spectrum disorder-related traits
1633 European ancestry trios, 942 trios
Sepsis from pneumonia (survival)
359 European ancestry non-survivor cases, 1,194 European ancestry survivor cases
106 European ancestry non-survivor cases, 432 European ancestry survivor cases
Affymetrix, Illumina [5888277] (imputed)
6,036 European ancestry cases, 3,757 European ancestry controls
Pulmonary artery enlargement and chronic obstructive pulmonary disease
1,006 European ancestry cases, 260 African American cases, 2,712 European ancestry smoker controls, 1,749 African American smoker controls
Pulmonary artery enlargement in chronic obstructive pulmonary disease
1,006 European ancestry cases, 260 African American cases, 3,281 European ancestry controls, 494 African American controls
3,281 European ancestry cases, 494 African American cases, 2,712 European ancestry smoker controls, 1,749 African American smoker controls
8,631 European ancestry individuals
Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid)
Vitamin B levels in ischemic stroke
Type 1 diabetes and autoimmune thyroid diseases
346 European ancestry cases, 727 European ancestry controls
185 European ancestry cases, 340 European ancestry controls
1,656 Chinese ancestry cases, 3,394 Chinese ancestry controls
2,152 Chinese ancestry cases, 2,476 Chinese ancestry controls, 460 Thai ancestry cases, 965 Thai ancestry controls
324 African American cases, 273 African American controls, 757 European ancestry cases, 940 European ancestry controls
434 European ancestry cases, 1,939 European ancestry controls
1,109 European ancestry cases, 2,264 European ancestry controls
Adult antisocial behavior
498 European ancestry individuals from alcohol dependence affected families
Pharmacokinetics of antidepressant drugs in severe mental disorder (concentration dose ratio)
Up to 320 European ancestry cases
Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio)
Up to 185 European ancestry cases
Pharmacokinetics of antipsychotic drugs in severe mental disorder (concentration drug ratio)
Up to 829 European ancestry cases
Pharmacokinetics of olanzapine in severe mental disorder (concentration dose ratio)
Up to 290 European ancestry cases
354 Han Chinese ancestry cases
327 Han Chinese ancestry cases
Leishmaniasis (visceral)
989 Indian ancestry cases, 1,089 Indian ancestry controls, 357 Brazilian ancestry cases, 1,613 Brazilian ancestry unaffected relatives
951 Indian ancestry cases, 990 Indian ancestry controls
Serum IgE levels
1,854 Hispanic asthmatic individuals, 1,480 Hispanic individuals
454 Hispanic asthmatic individuals
Yang-deficiency constitution
30 cases, 30 balanced constitution controls
3,994 European ancestry cases, 7,699 European ancestry controls
6,268 European ancestry cases, 14,172 European ancestry controls, 5,033 cases, 5,707 controls
Personality disorders
200 European ancestry Cluster B personality disorder cases, 200 European ancestry Cluster C cases, 600 European ancestry controls
554 Korean ancestry individuals
1,575 Korean ancestry individuals
Chronic obstructive pulmonary disease-related biomarkers
Up to 1,951 European ancestry smokers
481 Han Chinese ancestry cases, 2,025 Han Chinese ancestry controls
1,088 Han Chinese ancestry cases, 1,063 Han Chinese ancestry controls
1,249 African American individuals
Serum tamsulosin hydrochloride concentration
182 Japanese ancestry individuals
1,529 European ancestry cases, 3,399 European ancestry controls
2,148 European ancestry cases, 1,309 European ancestry controls
13,105 African American individuals
Sagittal craniosynostosis
130 European ancestry trios
172 cases, 548 controls
Musician's dystonia
127 European ancestry cases, 984 European ancestry controls
116 European ancestry cases, 125 European ancestry controls
2,191 European ancestry cases, 1,434 European ancestry controls
Gray matter volume (schizophrenia interaction)
74 Han Chinese ancestry cases, 51 Han Chinese ancestry controls
Anterior chamber depth
1,752 Malay ancestry individuals, 1,860 Indian ancestry individuals, 872 Chinese ancestry individuals
824 Chinese ancestry individuals
818 European ancestry cases, 1,396 European ancestry controls
Up to 907 European ancestry cases, up to 2,830 European ancestry controls, up to 449 African American cases, up to 480 African American controls
312 European ancestry cases, 1,115 European ancestry controls
594 European ancestry cases, 806 European ancestry controls, 208 Japanese ancestry cases, 1,1016 Japanese controls
Food antigen IgG levels
1,367 Mexican Americans from 63 families
Fibromyalgia
300 European ancestry female cases, 203 European ancestry female controls
940 European ancestry female cases, 601 European ancestry female controls
1,138 European ancestry cases, 1,120 European ancestry normal or lean controls
1,181 European ancestry cases, 1,960 European ancestry normal or lean controls, 981 European ancestry cases and 1,430 European ancestry controls from 715 families
Affymetrix, Illumina [1596878] (imputed)
481 Japanese ancestry cases, 2,963 Japanese ancestry controls
5,737 Japanese ancestry cases, 26,931 Japanese ancestry controls
77 European ancestry lymphoblastoid cell lines, 87 Yoruban ancestry lymphoblastoid cell lines, 83 African American lymphoblastoid cell lines
382 Han Chinese ancestry indiviudals
559 Han Chinese ancestry indiviudals
Up to 25,539 European ancestry individuals, 10,168 Japanese ancestry individuals
Up to 53,190 European ancestry individuals, 9,380 Japanese ancestry individuals
7,473 European ancestry cases, 5,984 European ancestry controls
194 European ancestry cases, 219 European ancestry controls
3,878 cases, 4,831 controls
4,046 Han Chinese ancestry cases, 3,938 Han Chinese ancestry controls
603 North Indian ancestry cases, 622 North Indian ancestry controls
733 North Indian ancestry cases, 1,148 North Indian ancestry controls
211 European ancestry cases, 1,719 European ancestry controls
159 European ancestry cases, 998 European ancestry controls, 2,288 cases, 4,374 controls
920 European ancestry individuals
Plasma plasminogen levels
up to 3,244 European ancestry individuals
Vogt-Koyanagi-Harada syndrome
774 Han Chinese ancestry cases, 2,009 Han Chinese ancestry controls
764 Han Chinese ancestry cases, 3594 Han Chinese ancestry controls
Affymetrix, Illumina [2208258] (imputed)
28,190 African American individuals, 1,188 Nigerian ancestry individuals
69,395 European ancestry individuals, 5,266 African American individuals, 6,497 African ancestry individuals, 19,601 East Asian ancestry individuals
Affymetrix, Illumina [~ 2420000] (imputed)
1,755 European ancestry cases, 5,314 European ancestry controls
1,658 European ancestry cases, 28,962 European ancestry controls, 1,725 cases, 3,791 controls
Hip circumference (psychosocial stress interaction)
2,460 European ancestry individuals, 548 Chinese ancestry individuals, 1,547 African American individuals, 1,250 Hispanic individuals
3,157 European ancestry individuals
1,941 European ancestry individuals
6,834 European ancestry individuals
Diffuse large B cell lymphoma
3,857 European ancestry cases, 7,666 European ancestry controls
1,359 European ancestry cases, 4,557 European ancestry controls
2,867 Chinese ancestry cases, 2,285 Chinese ancestry controls, 2,246 Korean ancestry cases, 2,052 Korean ancestry controls
5,029 Chinese ancestry cases, 5,302 Chinese ancestry controls, 6,066 Korean ancestry cases, 8,003 Korean ancestry controls, 6,572 Japanese ancestry cases, 6,539 Japanese ancestry controls, 16,003 European ancestry cases, 41,335 European ancestry controls
Aggressive periodontitis (sex interaction)
329 European ancestry cases, 983 European ancestry controls
382 European ancestry cases, 489 European ancestry controls
White matter hyperintensity volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
466 European ancestry individuals
4,593 European ancestry female twins
3,033 European ancestry female twins, 1,418 European ancestry females, 1,579 European ancestry males
Response to chemotherapy in breast cancer (hypertension) (bevacizumab)
255 European ancestry cases, 387 European ancestry controls
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab)
972 European ancestry cases, 1,064 European ancestry controls
Birdshot chorioretinopathy
117 European ancestry cases, 693 European ancestry controls
30 European ancestry cases, 2,793 European ancestry controls
Expressive vocabulary in infants
6,851 European ancestry 15-18-month-old children, 6,299 European ancestry 24-30-month-old children
2,038 European ancestry 15-18-month-old children, 4,520 European ancestry 24-30-month-old children
1,816 European ancestry cases, 7,877 European ancestry controls
1,281 European ancestry cases, 3,218 European ancestry controls
Affymetrix, Illumina [1004829] (imputed)
28 European ancestry child cases, 19 European ancestry child controls, 11 African American child cases, 4 African American child controls, 18 Hispanic child cases, 14 Hispanic child controls, 9 Biracial child cases, 5 Biracial child controls
18 European ancestry child cases, 367 European ancestry child controls, 1 African American child cases, 28 African American child controls, 6 Hispanic child cases, 28 Hispanic child controls, 13 Biracial child cases, 38 Biracial child controls
Persistent attention-deficit hyperactivity disorder
607 European ancestry adult cases, 584 European ancestry adult controls
2,104 European ancestry adult cases, 1,901 European ancestry adult controls
1,417 Han Chinese ancestry cases, 1,008 Han Chinese ancestry controls
3,067 Han Chinese ancestry cases, 7,926 Han Chinese ancestry controls
Circulating phylloquinone levels
2,138 European ancestry individuals
Mammographic density
239 European ancestry low mammographic density females, 239 European ancestry high mammographic density females
23,986 European ancestry individuals
Up to 24,986 European ancestry individuals
Iron status biomarkers (transferrin levels)
572 European ancestry cases, 2,491 European ancestry controls
Affymetrix, Illumina [6494962] (imputed)
8,424 European ancestry cases, 6,996 South Asian ancestry cases, 15,062 controls
21,408 cases, 19,185 controls
1,739 European ancestry cases, 5,199 European ancestry controls
1,144 European ancestry cases, 3,151 European ancestry controls
Acute anterior uveitis (with or without ankylosing spondylitis)
238 European ancestry primary acute anterior uveitis cases, 1,199 European ancestry cases with acute anterior uveitis and ankylosing spondylitis, 9,564 European ancestry controls
1,199 European ancestry cases, 1,731 European ancestry controls
55,796 European ancestry individuals
43,445 European ancestry individuals, 1,849 Chinese ancestry individuals, 2,502 Malay ancestry individuals, 2,476 Asian Indian ancestry individuals, 1,855 Asian ancestry individuals
Blood pressure (age interaction)
Bone mineral density (paediatric, upper limb)
8,007 European ancestry children, 289 Surinamese ancestry children, 300 Turkish ancestry children, 232 Moroccan ancestry children, 588 children
Bone mineral density (paediatric, total body less head)
Bone mineral density (paediatric, lower limb)
Bone mineral density (paediatric, skull)
7,976 European ancestry children, 289 Surinamese ancestry children, 300 Turkish ancestry children, 232 Moroccan ancestry children, 588 children
Up to 1,238 European ancestry cases, up to 2,617 European ancestry controls
Up to 1,837 European ancestry cases, up to 3,803 European ancestry controls, up to 2,806 cases, up to 2,150 controls, up to 603 Costa Rican ancestry cases and their parents
Response to cytidine analogues (gemcitabine)
60 European ancestry lymphoblastoid cell lines, 54 African American lymphoblastoid cell lines, 60 Han Chinese ancestry lymphoblastoid cell lines
Response to cytadine analogues (cytosine arabinoside)
Up to 172 European ancestry cases, 1,398 European ancestry controls
Up to 485 European ancestry cases, up to 716 European ancestry controls
1,809 European ancestry cases, 570 European ancestry controls, 2,482 African American cases, 836 African American controls
4,498 European ancestry individuals, 2,114 African American individuals
241 European ancestry successful abstainers, 309 European ancestry unsuccessful abstainers
Skin youthfulness
218 Ashkenazi Jewish cases, 210 Ashkenazi Jewish controls
408 Ashkenazi Jewish cases, 399 Ashkenazi Jewish controls
Fibrinogen levels (smoking status, alcohol consumption or body mass index interaction)
up to 80,607 European ancestry individuals
528 Han Chinese ancestry cases
340 Han Chinese ancestry cases, 409 European ancestry cases
Airway wall thickness
2,640 individuals
up to 714 individuals
Social autistic-like traits
965 European ancestry young adult individuals
84 European ancestry mucinous cases, 114 European ancestry endometroid or clear cell cases, 75 European ancestry low malignant potential serous cases, 272 European ancestry invasive serous cases, 398 European ancestry controls
1,483 European ancestry mucinous cases, 2,903 European ancestry endometroid or clear cell cases, 892 European ancestry low malignant potential serous cases, 6,881 European ancestry invasive serous cases, up to 21,530 European ancestry controls
2,540 European ancestry cases, 2,029 European ancestry controls
Affymetrix, Illumina [1216213] (imputed)
31 European ancestry cases and 63 European ancestry controls from 32 families
1,257 cases, 1,336 controls
5,084 European ancestry cases, 5,388 European ancestry controls, 1,139 cases, 1,055 controls
11 European ancestry cases and 19 European ancestry controls from 2 affected families, 60 controls
199 European ancestry cases, 85 European ancestry controls
Asthma and hay fever
6,685 European ancestry cases, 14,091 European ancestry controls
878 European ancestry cases, 2,455 European ancestry controls
IgE levels in asthmatics
877 Korean ancestry cases
IgE levels in asthmatics (D.p. specific)
329 Korean ancestry D.p.-positive cases, 548 Korean ancestry D.p.-negative cases
IgE levels in asthmatics (D.f. specific)
404 Korean ancestry D.f.-positive cases, 473 Korean ancestry D.f.-negative cases
912 European ancestry cases, 903 European ancestry controls
636 individuals from 224 trios
108 Han Chinese ancestry high-responder cases, 77 Han Chinese ancestry non-responder controls
1,336 Han Chinese ancestry high-responder cases, 420 Han Chinese ancestry non-responder controls
Lipopolysaccharide induced cytokine levels
130 European ancestry individuals
586 European ancestry individuals
12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ancestry controls
21,491 European ancestry cases, 55,647 European ancestry controls
52,253 European ancestry indiviudals
32,917 European ancestry individuals, 6,070 African American individuals, 849 Hispanic individuals, 8,637 East Asian ancestry individuals
Affymetrix, Illumina [2762059] (imputed)
2,774 European ancestry individuals
22,789 European ancestry and Erasmus Rucphen individuals
Beta-2 microglubulin plasma levels
6,728 European ancestry individuals
421 European ancestry large artery atherosclerosis cases, 741 European ancestry ischemic stroke cases, 1,244 European ancestry controls
1,715 European ancestry large artery atherosclerosis cases, 9,552 European ancestry ischemic stroke cases, 52,695 European ancestry controls
Bladder cancer (smoking interaction)
560 European ancestry never smoker cases, 2,442 European ancestry ever smoker cases, 1,406 European ancestry never smoker controls, 3,005 European ancestry ever smoker controls
494 European ancestry never smoker cases, 1,927 European ancestry ever smoker cases, 2,257 European ancestry never smoker controls, 3,490 European ancestry ever smoker controls
1,102 European ancestry cases, 405 European ancestry controls
1,133 European ancestry cases, 371 European ancestry controls
2,023 European ancestry children
2,008 Chinese ancestry adult individuals, 2,281 Malay ancestry adult individuals, 2,142 Indian ancestry adult individuals, 929 Chinese ancestry children
70 unaffected relatives of cases with bipolar disorder, 80 controls
White matter integrity (bipolar disorder risk interaction)
1,550 European ancestry cases, 3,084 European ancestry controls
Thoracic aortic aneurysms and dissections
765 European ancestry cases, 874 European ancestry controls
548 European ancestry cases, 626 European ancestry controls
Serum vitamin D-binding protein levels
1,380 European ancestry males
62,553 European ancestry individuals, 9,308 South Asian ancestry individuals
63,506 European ancestry individuals
Affymetrix, Illumina, Perlegen [2711806] (imputed)
433 Han Chinese ancestry ACPA positive cases, 519 Han Chinese ancestry ACPA negative cases, 943 Han Chinese ancestry controls
1,032 Han Chinese ancestry ACPA positive cases, 1,100 Han Chinese ancestry ACPA negative cases, 2,553 Han Chinese ancestry controls
952 Han Chinese ancestry cases, 943 Han Chinese ancestry controls
Functional impairment in major depressive disorder, bipolar disorder and schizophrenia
2,246 European ancestry individuals
827 Japanese ancestry cases, 3,323 Japanese ancestry controls
709 Japanese ancestry cases, 15,571 Japanese ancestry controls
6,223 Korean ancestry individuals
2,720 Korean ancestry individuals
Protein biomarker
3,776 European ancestry individuals
3,516 individuals
2,687 European ancestry individuals
3,137 European ancestry individuals
1,658 European ancestry child cases, 4,723 European ancestry controls
1,449 European ancestry child cases, 1,488 European ancestry controls
Up to 17,296 European ancestry female individuals
Up to 2,700 individuals, Up to 2,000 European ancestry cardiovascular heart disease cases and controls
Acute myeloid leukemia
118 Korean ancestry individuals
129 Korean ancestry individuals
532 Korean ancestry cases, 733 Korean ancestry controls
1,779 Korean ancestry cases, 1,709 Korean ancestry controls
1,147 European ancestry ACPA positive RA cases, 774 European ancestry ACPA negative RA cases, 1,079 European ancestry controls
887 European ancestry ACPA positive RA cases, 1,218 European ancestry controls
1,505 European ancestry cases, 28,890 European ancestry controls
1,060 European ancestry cases, 515 European ancestry controls
1,033 Japanese ancestry cases, 1,042 Japanese ancestry controls, 1,043 Latino cases, 1,057 Latino controls
1,583 Japanese ancestry cases, 3,386 Japanese ancestry controls, 1,854 European ancestry cases, 3,748 European ancestry controls
(see Medland, 2010)
589 European ancestry cases, 5,199 European ancestry controls
2,057 European ancestry cases, 3,416 European ancestry controls
1,583 Japanese ancestry cases, 1,898 Japanese ancestry controls
4,584 Japanese ancestry cases, 225 Korean ancestry distal cases, 2,973 East Asian ancestry controls
931 European ancestry cases, 4,120 European ancestry controls
2,571 European ancestry cases, 921 European ancestry controls
917 European ancestry individuals, 677 African American individuals, 209 Hispanic individuals, 73 Asian ancestry individuals, 8 Native American ancestry individuals, 2 individuals
Response to methotrexate in rheumatoid arthritis
281 Indian ancestry good responder cases, 157 Indian ancestry poor responder cases
1,465 European ancestry cases, 6,417 European ancestry controls
1,071 European ancestry cases, 953 cases, 1,853 controls
Heschl's gyrus morphology
1,778 European ancestry individuals, 1,276 individuals
Affymetrix, Illumina [4103035] (imputed)
Lung cancer (household air pollution interaction)
1,731 Asian ancestry never smoker cases, 1,349 Asian ancestry never smoker controls
Airway hyperresponsiveness
994 European ancestry asthma cases
650 European ancestry asthma cases, 3,354 European ancestry chronic obstructive pulmonary disease cases
up to 1,782 Latino child cases
529 Latino child cases
Fractional exhaled nitric oxide levels
610 European ancestry adult individuals, 601 Hutterite (founder/genetic isolate) adult individuals
450 Talana (founder/genetic isolate) adult individuals, 8,858 European ancestry children
Exhaled carbon monoxide levels
1,521 European ancestry smoker individuals, 247 African American smoker individuals
Serum VEGFR2 concentration
736 Old Order Amish
Asthma or chronic obstructive pulmonary disease
920 European ancestry Asthma cases, 1,030 European ancestry Chronic obstructive pulmonary disease cases, 4,585 European ancestry controls
461 European ancestry Asthma cases, 118 European ancestry Chronic obstructive pulmonary disease cases, 656 European ancestry controls, 720 European, African American and Hispanic Asthma cases, 1,019 European, African American and Hispanic Chronic obstructive pulmonary disease cases, 19,173 European, African American and Hispanic controls, 1,106 Asthma cases, 1,806 Chronic obstructive pulmonary disease cases, 18,580 controls
91,462 European ancestry individuals
30,062 European ancestry individuals, 7,964 African American individuals
Affymetrix, Illumina [2373958] (imputed)
17,479 European ancestry high consumption individuals, 31,049 European ancestry no or low consumption individuals
6,497 European ancestry high consumption individuals, 432 African American high consumption individuals, 6,972 European ancestry no or low consumption individuals, 3,413 African American no or low consumption individuals
Affymetrix, Illumina [2376205] (imputed)
Very long-chain saturated fatty acid levels (fatty acid 20:0)
10,129 European ancestry individuals
Very long-chain saturated fatty acid levels (fatty acid 22:0)
Very long-chain saturated fatty acid levels (fatty acid 24:0)
7,915 European ancestry individuals
Lipoprotein (a) - cholesterol levels
1,376 Old Order Amish individuals
5,275 European ancestry individuals
2,728 European ancestry cases, 7,758 European ancestry controls
1,795 European ancestry cases, 5,586 European ancestry controls
510 European ancestry
2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls
5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals
Affymetrix, Illumina [1636380] (imputed)
2,369 Malay ancestry individuals, 2,200 Indian ancestry individuals, 2,571 Chinese ancestry individuals
214 European ancestry prostate cancer cases, 188 European ancestry controls
489 European ancestry prostate cancer cases
Acute lymphoblastic leukemia (adolescents and young adults)
99 European ancestry cases, 1,381 European ancestry controls, 15 African American cases, 1,363 African American controls, 76 Hispanic cases, 1,008 Hispanic controls, 118 other ancestry cases, 2,909 other ancestry controls
72 European ancestry cases, 3,667 European ancestry controls, 9 African American cases, 1,076 African American controls, 34 Hispanic cases, 501 Hispanic controls, 47 other ancestry cases, 511 other ancestry controls
480 European ancestry cases, 801 European ancestry controls
1,305 European ancestry cases, 2,049 European ancestry controls
Red wine liking
398 Carlantino (founder/genetic isolated) individuals, 751 Friuli Venezia Giulia (founder/genetic isolated) individuals, 1,122 Val Borbera (founder/genetic isolated) individuals
1,246 Erasmus Rucphen (founder/genetic isolated) individuals, 353 Silk Road individuals
White wine liking
381 Carlantino (founder/genetic isolated) individuals, 744 Friuli Venezia Giulia (founder/genetic isolated) individuals, 1,115 Val Borbera (founder/genetic isolated) individuals
1,261 Erasmus Rucphen (founder/genetic isolated) individuals, 335 Silk Road individuals
10,352 APOE e4+ cases, 9,207 APOE e4+ controls, 7,184 APOE e4- cases, 26,968 APOE e4- controls
1,250 APOE e4+ European ancestry cases, 536 APOE e4+ European ancestry controls, 718 APOE e4- European ancestry cases, 1,699 APOE e4- European ancestry controls
10,352 cases, 9,207 controls
1,250 European ancestry cases, 536 European ancestry controls
7,184 cases, 26,968 controls
718 European ancestry cases, 1,699 European ancestry controls
361 Martu Australian Aboriginal ancestry individuals
89 Martu Australian Aboriginal ancestry cases, 302 Martu Australian Aboriginal ancestry controls
Response to thiopurine immunosuppressants in inflammatory bowel disease (pancreatitis) (azathioprine and mercaptopurine)
172 European ancestry cases, 2,035 European ancestry controls
78 European ancestry cases, 472 controls
Affymetrix, Illumina [2819700] (imputed)
858 Chinese ancestry cases, 1,248 Chinese ancestry controls
1,663 Chinese ancestry cases, 1,874 Chinese ancestry controls
15 Russian ancestry male long endurance athletes, 17 Russian ancestry female long endurance athletes, 31 Russian ancestry middle and short endurance athletes, 17 Russian ancestry middle and short endurance athletes
2,514 Chinese ancestry cases, 1,130 Chinese ancestry controls
6,600 Chinese ancestry cases, 8,127 Chinese ancestry controls
Schizophrenia (inflammation and infection response interaction)
460 Ashkenazi Jewish schizophrenia cases, 241 Ashkenazi Jewish controls
Bipolar disorder (inflammation and infection response interaction)
397 Ashkenazi Jewish bipolar disorder cases, 241 Ashkenazi Jewish controls
Colorectal cancer (aspirin and/or NSAID use interaction)
8,634 European ancestry cases, 8,553 European ancestry controls
1 Afghanistan ancestry case, 154 Middle Eastern/North African ancestry cases, 2 Cape Verdian cases, 1 Curacao case, 1 Dominican Republic ancestry cases, 54 European ancestry cases, 1 Israeli case, 1 Surinamese ancestry case, 1 Thai ancestry case, 1 Chinese ancestry case, 119 Turkish ancestry cases, 87 Middle Eastern/North African ancestry controls, 5,756 controls
82 European ancestry cases, 98 European ancestry controls
2,030 Turkish cases, 1,904 Turkish controls
Antibody level in response to infection
1,932 Mexican American individuals
Diisocyanate-induced asthma
74 European ancestry cases, 824 European ancestry controls
Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor
1,794 European ancestry cases, 18 African and Asian ancestry cases
1,922 European ancestry cases, 19 African and Asian ancestry cases
AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor
ADAMTS13 activity
3,423 European ancestry individuals
2,025 European ancestry individuals
Thiazide-induced adverse metabolic effects in hypertensive patients
425 European ancestry cases, 342 African American cases
Proinsulin levels
10,701 European ancestry individuals
16,378 European ancestry individuals
506 European ancestry cases, 510 European ancestry controls
Hepatitis
1,500 Korean ancestry cases, 1,500 Korean ancestry controls
Motion sickness
80,494 European ancestry individuals
325 European ancestry older adult individuals
498 European ancestry older adult individuals
Affymetrix, Illumina [at least 646791] (imputed)
Depressive symptoms (SSRI exposure interaction)
175 users, 6,268 nonusers
1,048 Japanese ancestry cases, 1,334 Japanese ancestry controls
51,719 European ancestry individuals, 1,473 Erasmus Rucphen (founder/genetic isolate) individuals, 327 Korculan (founder/genetic isolate) individuals, 430 Orcadian (founder/genetic isolate) individuals
Affymetrix, Illumina [2478500] (imputed)
972 European ancestry cases, 1,977 European ancestry controls
423 European ancestry cases, 467 European ancestry controls
2,567 European ancestry cases, 17,163 European ancestry controls, 381 African American ancestry cases, 352 African American ancestry controls, 678 Pakistani ancestry cases, 4,453 Pakistani ancestry controls
1,003 European ancestry cases, 7,745 European ancestry controls
401 European ancestry cases, 17,164 European ancestry controls, 23 African American ancestry cases, 352 African American ancestry controls, 257 Pakistani ancestry cases, 4,453 Pakistani ancestry controls
1,022 European ancestry cases, 17,164 European ancestry controls, 183 African American ancestry cases, 352 African American ancestry controls, 754 Pakistani ancestry cases, 4,453 Pakistani ancestry controls
552 European ancestry cases, 17,164 European ancestry controls, 74 African American ancestry cases, 352 African American ancestry controls, 293 Pakistani ancestry cases, 4,453 Pakistani ancestry controls
292 European ancestry cases, 17,164 European ancestry controls, 77 African American ancestry cases, 352 African American ancestry controls, 232 Pakistani ancestry cases, 4,453 Pakistani ancestry controls
Up to 3,248 Japanese ancestry individuals
3,460 Japanese ancestry individuals
6,234 East Asian ancestry individuals, 2,007 European ancestry individuals
8,015 individuals
7,471 individuals
Behavioral disinhibition
1,129 European ancestry individuals, 477 Hispanic individuals, 114 Black individuals, 42 Native American ancestry individuals, 40 Asian or Pacific Islander ancestry individuals, 99 individuals
3,378 European ancestry individuals
up to 56,910 European ancestry men, up to 86,570 European ancestry women
up to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African American/Afro-Caribbean ancestry men, 6,258 African American/Afro-Caribbean ancestry women, 2,285 South Asian ancestry men, 506 South Asian ancestry women, 195 Seychellois ancestry men, 266 Seychellois ancestry women
Affymetrix, Illumina, Perlegen [up to 2542447] (imputed)
472 non-externalizing cases, 796 externalizing cases
436 non-externalizing European ancestry cases, 801 externalizing European ancestry cases
2,215 Western European ancestry cases, 8,566 Western European ancestry controls
2,844 European ancestry cases, 7,270 European ancestry controls
Platinum-induced myelosuppression in non-small cell lung cancer
328 Han Chinese ancestry cases
876 Han Chinese ancestry cases
Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide)
49 European ancestry individuals
Subcortical brain region volumes
up to 13,171 European ancestry individuals
up to 15,130 European ancestry individuals, 545 Japanese ancestry individuals, 736 Mexican American individuals
IgG1 response to Plasmodium falciparum antigen (GLURP)
528 Sereer ancestry individuals from 130 families
IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7)
IgG1 response to Plasmodium falciparum antigen (MSP1)
528 Sereer ancestry individuals from 130 individuals
IgG3 response to Plasmodium falciparum antigen (MSP2 3D7)
IgG3 response to Plasmodium falciparum antigen (MSP2 FC27)
Glomerular filtration rate in non diabetics (creatinine)
118,448 European ancestry individuals
36,433 European ancestry individuals
Glomerular filtration rate in diabetics (creatinine)
11,522 European ancestry individuals
4,955 European ancestry individuals
32,834 European ancestry individuals
14,930 European ancestry individuals
12,385 European ancestry cases, 104,780 European ancestry controls
33,972 European ancestry individuals
133,413 European ancestry individuals
42,166 European ancestry individuals, up to 16,471 African ancestry individuals, up to 42,296 Asian ancestry individuals
133,413 European ancestry individuals, 16,840 African ancestry individuals
6,891 European ancestry cases, 54,566 European ancestry controls
810 European ancestry cases, 5,600 European ancestry controls
60 Japanese ancestry world-class cases, 116 Japanese ancestry controls
at least 140 Sub-Saharan African ancestry cases, at least 275 Sub-Saharan African ancestry controls, at least 606 European ancestry cases, at least 978 European ancestry controls, at least 688 Japanese ancestry controls, 78 cases, 101 controls.
Endurance athleticism
at least 343 Sub-Saharan African ancestry cases, at least 275 Sub-Saharan African ancestry controls, at least 837 European ancestry cases, at least 978 European ancestry controls, at least 137 Japanese ancestry cases, at least 688 Japanese ancestry controls, 78 cases, 101 controls.
Brain arteriovenous malformations (sporadic)
515 European ancestry cases, 1191 European ancestry controls
608 European ancestry cases, 744 European ancestry controls
Acute mountain sickness
43 Nepalese cases, 56 Nepalese controls
102 Nepalese cases, 100 Nepalese controls
38,937 European ancestry morning chronotype individuals, 50,346 European ancestry evening chronotype individuals
38,937 European ancestry morning individuals, 50,346 European ancestry evening individuals, at least 32,842 European ancestry neutral individuals
100,420 European ancestry individuals
8,724 European ancestry evening chronotype individuals, 26,948 European ancestry morning chronotype individuals
up to 4,548 European ancestry daily smoker individuals
755 European ancestry daily smoker individuals
Affymetrix, Illumina, Perlegen [up to 8585905] (imputed)
Alzheimer disease and age of onset
2,478 European ancestry cases, 979 ancestry controls both from the same 1,070 families
639 European ancestry cases
3,372 European ancestry cases
Survival in breast cancer (estrogen-receptor negative)
597 European ancestry cases
1,351 European ancestry cases
352 European ancestry cases with endocrine therapy, 254 European ancestry cases without endocrine therapy, 597 European ancestry controls
3,330 European ancestry cases with endocrine therapy, 42 European ancestry cases without endocrine therapy, 1,351 European ancestry controls
592 European ancestry cases, 2,676 European ancestry controls
367 European ancestry cases, 5,159 European ancestry controls
Early response to risperidone in schizophrenia
86 European ancestry cases
5,008 European ancestry prepubescent females, 5,082 European ancestry prepubescent males, 4,238 European ancestry pubescent females, 4,185 European ancestry pubescent males, 2,680 European ancestry post-pubescent females, 2,496 European ancestry post-pubescent males
Obsessive-compulsive symptoms
6,931 individuals
Affymetrix, Illumina, Perlegen [31265038] (imputed)
Serum lycopene concentrations
441 Old Order Amish individuals from 308 families
Manic episodes in bipolar disorder
706 European ancestry cases
Depressive episodes in bipolar disorder
723 European ancestry cases
Depressive and manic episodes in bipolar disorder
Incident coronary heart disease
2406 European ancestry cases, 21,618 European ancestry controls
3059 European ancestry cases, 28,087 European ancestry controls
Affymetrix, Illumina [2543842] (imputed)
Incident myocardial infarction
1,570 European ancestry cases, at least 21,618 European ancestry controls
2,328 European ancestry cases, 546 African American ancestry cases, 7655 African American ancestry controls, up to 35,233 European ancestry controls
Up to 31,457 European ancestry men, up to 35,030 European ancestry women, up to 8,259 Indian Asian ancestry men, up to 1,030 Indian Asian ancestry women, 973 Korean ancestry men, 1,360 Korean ancestry women, 154 African American men, 262 African American women
Up to 12,480 European ancestry men, up to 10,055 European ancestry women, 315 Jamaican ancestry men, 774 Jamaican ancestry women
Affymetrix, Illumina, Perlegen [at least 1958375] (imputed)
50 Han Chinese ancestry seropositive cases, 50 Han Chinese ancestry seropositive controls
282 Han Chinese ancestry seropositive cases, 278 Han Chinese ancestry seropositive controls
Low bone mineral density (spine)
2,894 Icelandic cases, 206,485 Icelandic controls (includes non-array genotyped, whole-genome imputed individuals)
Low bone mineral density (hip)
2,678 Icelandic cases, 206,701 Icelandic controls (includes non-array genotyped, whole-genome imputed individuals)
Proteinuria in chronic kidney disease
up to 744 European ancestry child cases, up to 397 Turkish ancestry child cases
658 European ancestry child cases, 1,347 European ancestry child controls
Proteinuria and chronic kidney disease
294 European ancestry child cases, 1,347 European ancestry child controls
Glomerular filtration rate in chronic kidney disease
up to 744 Central European ancestry child cases, up to 397 Turkish ancestry child cases
178 African American females, 159 African American males, 474 European ancestry females, 434 European ancestry males, 54 Hispanic and other ancestry females, 72 Hispanic and other ancestry males
242 European ancestry females, 239 European ancestry males
Longitudinal change in brain amyloid plaque burden
41 European ancestry Alzheimer's disease cases, 294 European ancestry Mild Cognitive Impairment cases, 160 European ancestry cognitively normal individuals
15,463 Japanese ancestry cases, 26,183 Japanese ancestry controls
20,490 East Asian ancestry cases, 22,922 East Asian ancestry controls, 38,947 European ancestry cases, 121,903 European ancestry controls, 10,587 South Asian ancestry cases, 14,378 South Asian ancestry controls, 3,848 Mexican/Latino cases, 4,366 Mexican/Latino controls
3,100 European ancestry cases, 7,667 European ancestry controls
1,958 cases, 5,530 controls
antipsychotic drug dosage in schizophrenia or schizoaffective disorder
up to 39 European ancestry schizophrenia cases, up to 40 European ancestry schizoaffective cases
279 European ancestry cases
965 European ancestry cases
12,558 Hispanic/Latin American individuals
214 Asian ancestry individuals, 1,183 African American individuals, 5,638 European ancestry individuals
Obstructive sleep apnea (average oxygen saturation during sleep)
12,557 Hispanic/Latin American ancestry individuals
214 Asian ancestry individuals, 1,183 African American ancestry individuals, 5,638 European ancestry individuals
Obstructive sleep apnea trait (average respiratory event duration)
10,238 Hispanic/Latin American ancestry individuals
Glucocorticoid-induced osteonecrosis (time dependent analysis)
164 European ancestry osteonecrosis cases, 4 Black osteonecrosis cases, 58 Hispanic osteonecrosis cases, 5 Asian ancestry osteonecrosis cases, 19 other ancestry osteonecrosis cases, 1,111 European ancestry treated controls, 135 Black treated controls, 543 Hispanic treated controls, 43 Asian ancestry treated controls, 203 other ancestry treated controls
Glucocorticoid-induced osteonecrosis (time independent analysis)
235 osteonecrosis cases, 1,687 treated controls
110 European ancestry osteonecrosis cases, 21 Black osteonecrosis cases, 10 Hispanic osteonecrosis cases, 1 Asian ancestry osteonecrosis case, 8 other ancestry osteonecrosis cases, 366 European ancestry treated controls, 88 Black treated controls, 29 Hispanic treated controls, 5 Asian ancestry treated controls, 32 other ancestry treated controls
Glucocorticoid-induced osteonecrosis (age 10 years and older)
230 osteonecrosis cases, 1,238 treated controls
Glucocorticoid-induced osteonecrosis
274 European ancestry osteonecrosis cases, 25 Black osteonecrosis cases, 68 Hispanic osteonecrosis cases, 6 Asian ancestry osteonecrosis cases, 27 other ancestry osteonecrosis cases, 1,477 European ancestry treated controls, 223 Black treated controls, 572 Hispanic treated controls, 48 Asian ancestry treated controls, 235 other ancestry treated controls
Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis
93 Korean ancestry responder cases, 16 Korean ancestry non-responder cases
620 European ancestry cases, 10,588 European ancestry controls
Urinary albumin-to-creatinine ratio in diabetes
up to 5,825 European ancestry cases
up to 1,962 European ancestry cases
Affymetrix, Illumina [2191945] (imputed)
Urinary albumin-to-creatinine ratio in non-diabetics
up to 46,051 European ancestry individuals
Microalbuminuria
up to 54,116 European ancestry cases
up to 54,450 European ancestry individuals
Progression free survival in metastatic colorectal cancer (CAPOX-B vs CAPOX-B plus cetuximab)
256 cases treated with CAPOX-B plus cetuximab, 264 cases treated with CAPOX-B
Progression free survival in metastatic colorectal cancer (chemotherapy interaction)
394 European American individuals with periodontal health, 389 European American individuals with mild-moderate periodontitis, 192 European American individuals with severe periodontitis
Periodontal disease related phenotype (PCT2)
Periodontal disease related phenotype (PCT3)
Periodontal disease related phenotype (PCT4)
Periodontal disease related phenotype (PCT5)
Periodontal disease related phenotype (PCT6)
Skin colour saturation
5,857 European ancestry individuals
Perceived skin darkness
5,278 European ancestry individuals
2,668 European ancestry individuals
489 Japanese ancestry APOE-ε4 noncarrier cases, 6,463 Japanese ancestry APOE-ε4 noncarrier controls, 323 Japanese ancestry APOE-ε4 carrier cases, 1,484 Japanese ancestry APOE-ε4 carrier controls, 4 Japanese ancestry cases, 45 Japanese ancestry controls
528 Japanese ancestry APOE-ε4 noncarrier cases, 5,824 Japanese ancestry APOE-ε4 noncarrier controls, 480 Japanese ancestry APOE-ε4 carrier cases, 1,364 Japanese ancestry APOE-ε4 carrier controls, 3 Japanese ancestry cases, 24 Japanese ancestry controls
2,737 African American individuals
942 African American individuals
Percentage gas trapping
3,243 European ancestry chronic obstructive pulmonary disease cases, 901 African American chronic obstructive pulmonary disease cases, 3,062 European ancestry controls, 2,132 African American controls
Airway imaging phenotypes
5,385 European ancestry chronic obstructive pulmonary disease cases, 901 African American chronic obstructive pulmonary disease cases, 3,613 European ancestry controls, 2,132 African American controls
Emphysema imaging phenotypes
Response to inhaled glucocorticoid treatment in asthma (change in FEV1)
120 individuals
410 individuals
Lung cancer and family history of lung cancer
3,953 European ancestry lung cancer cases, 4,730 European ancestry lung cancer controls
Oligoclonal band status in multiple sclerosis
2,232 European ancestry OCB positive individuals, 275 European ancestry OCB negative individuals, 439 OCB positive individuals, 80 OCB negative individuals
3,026 OCB positive individuals, 452 OCB negative individuals
Immunoglobulin G index levels in multiple sclerosis
773 European ancestry Individuals, 165 Individuals
2,072 Individuals
Response to Homoharringtonine (cytotoxicity)
93 African American ancestry lymphoblastoid cell lines, 91 European ancestry lymphoblastoid cell lines, 94 Han Chinese ancestry lymphoblastoid cell lines
Affymetrix, Illumina [6750581] (imputed)
516 Turkish ancestry cases, 119 European ancestry cases, 462 Turkish ancestry controls, 993 European ancestry controls
3,777 European ancestry cases, 3,520 European ancestry smoker controls
Chronic bronchitis and chronic obstructive pulmonary disease
up to 1,662 European ancestry cases, up to 3,520 European ancestry smoker controls, 182 African American cases, 1,749 African American smoker controls
Chronic bronchitis in chronic obstructive pulmonary disease
1,662 European ancestry cases, 3,777 European ancestry controls
3,126 child cases
182 child cases
Colorectal or endometrial cancer
5,725 European ancestry colorectal carcinoma cases, 2,212 European ancestry endometrial carcinoma cases, 13,396 European ancestry controls
4,330 European ancestry endometrial carcinoma cases, 26,849 European ancestry controls
Endophenotypes for schizophrenia in healthy individuals
1,079 European ancestry male cases
1,563 European ancestry male cases
Perioperative myocardial infarction in coronary artery bypass surgery
112 cases, 1,321 controls
113 European ancestry cases, 509 European ancestry controls
Obesity in adult survivors of childhood cancer exposed to cranial radiation
365 obese individuals, 411 non-obese individuals
Obesity in adult survivors of childhood cancer not exposed to cranial radiation
359 obese individuals, 861 non-obese individuals
Lachrymal/Salivary gland lesion in type 1 autoimmune pancreatitis
50 Japanese ancestry cases with lesions, 53 Japanese ancestry cases without lesions
Response to stavudine in HIV (lipoatrophy)
49 Thai ancestry cases, 92 Thai ancestry controls
95 Thai ancestry cases, 95 Thai ancestry controls
up to 62,166 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 9657952] (imputed)
up 62,166 European ancestry individuals
Dementia and core Alzheimer's disease neuropathologic changes
up to 3,887 cases, up to 1,027 controls
up to 4,707 individuals
up to 4,232 individuals
Lewy body disease
up to 3,526 individuals
Vascular brain injury
up to 2,940 individuals
Hippocampal sclerosis
310 cases, 2,576 controls
1,673 cases, 1,134 controls
409 Japanese ancestry cases, 1,562 Japanese ancestry controls
240 Japanese ancestry cases, 869 Japanese ancestry controls
1,367 Sardinian cases, 1,658 Sardinian controls
201 Sardinian cases, 1,467 Sardinian controls, 61,485 European ancestry cases, 60,860 European ancestry controls
5,149 European ancestry cases, 279,870 European ancestry controls (includes non-array genotyped, whole-genome imputed individuals)
4,558 Korean ancestry individuals
4,093 Korean ancestry individuals
Classic bladder exstrophy
208 European ancestry cases, 1,703 European ancestry controls
Up to 627 Cilento (founder/genetic isolate) individuals, up to 2,296 Erasmus Rucphen (founder/genetic isolate) individuals, up to 1,650 Orcadian (founder/genetic isolate) individuals, up to 909 Vis (founder/genetic isolate) individuals, up to 58,179 European ancestry individuals
Up to 9,786 European ancestry individuals
Affymetrix, Illumina, Perlegen [6949614] (imputed)
Forced expiratory volume in 1 second (occupational environmental exposures interaction)
12,400 individuals
1,436 individuals
7,577 European ancestry cases, 9,979 European ancestry controls
Affymetrix, Illumina [~ 10000000] (imputed)
5,148 European ancestry users
1,357 European ancestry users, 5,387 European ancestry never users
Sex hormone levels
up to 2913 European ancestry individuals
3-hydroxypropylmercapturic acid levels in smokers
362 African American current smoker individuals, 329 Native Hawaiian ancestry current smoker individuals, 438 European ancestry current smoker individuals, 449 Latino current smoker individuals, 704 Japanese ancestry current smoker individuals
3-hydroxy-1-methylpropylmercapturic acid levels in smokers
361 African American current smoker individuals, 329 Native Hawaiian ancestry current smoker individuals, 440 European ancestry current smoker individuals, 452 Latino current smoker individuals, 702 Japanese ancestry current smoker individuals
Lapatinib-induced hepatotoxicity
775 European ancestry treated breast cancer cases, 236 East Asian ancestry treated breast cancer cases, 247 treated breast cancer cases
Response to zileuton treatment in asthma (FEV1 change interaction)
160 European and other ancestry zileuton-treated cases, 144 European and other ancestry placebo-controlled cases
149 European and other ancestry zileuton-treated cases, 73 European and other ancestry placebo-controlled cases
32 Hispanic ancestry cases, 16 Black cases, 14 European ancestry cases, 1 other ancestry case, 25 Hispanic ancestry controls, 6 Asian ancestry controls, 19 Black controls, 31 European ancestry controls, 3 other ancestry controls
2,868 African American ancestry individuals
24 Japanese ancestry cases, 121 Japanese ancestry controls
Paclitaxel-induced cytotoxicity
57 Japanese ancestry lymphoblastoid cell lines, 59 Han Chinese ancestry lymphoblastoid cell lines
77 European ancestry lymphoblastoid cell lines, 87 Yoruban ancestry lymphoblastoid cell lines, 83 African ancestry lymphoblastoid cell lines
2,194 European ancestry cases, 222,555 European ancestry controls
586 European ancestry cases, 2,111 European ancestry controls
Multiple myeloma and monoclonal gammopathy
2,194 European ancestry multiple myeloma cases, 251 European ancestry monoclonal gammopathy cases, 294,390 European ancestry controls
586 European ancestry multiple myeloma cases, 2,111 European ancestry controls
326 Han Chinese ancestry cases, 58 Dai Chinese ancestry cases, 40 Jingpo Chinese ancestry cases, 83 Uygur Chinese ancestry cases, 11 Hui Chinese ancestry cases, 20 East Asian cases
Sporadic pituitary adenoma
771 Han Chinese cases, 2,788 Han Chinese controls
2,542 Han Chinese cases, 3,620 Han Chinese controls
825 African American individuals
119 African American individuals, 1,221 European ancestry individuals
Yu-Zhi constitution type in type 2 diabetes
539 non-aboriginal Taiwanese ancestry low Yu-Zhi score individuals, 408 non-aboriginal Taiwanese ancestry high Yu-Zhi score individuals
Pyoderma gangrenosum in inflammatory bowel disease
92 European ancestry cases, 5,664 European ancestry controls
Erythema nodosum in inflammatory bowel disease
103 European ancestry cases, 5,653 European ancestry controls
Peak creatinine levels in vancomycin therapy
489 European ancestry individuals
Vancomycin trough in vancomycin therapy
745 European ancestry individuals
343 European ancestry individuals
Renal elimination rate in vancomycin therapy
Cough in response to angiotensin-converting enzyme inhibitor drugs
1,346 European ancestry ACE inhibitor-exposed cases, 178 African ancestry ACE inhibitor-exposed cases, 71 ACE inhibitor-exposed cases, 4,661 European ancestry ACE inhibitor-exposed controls, 701 African ancestry ACE inhibitor-exposed controls, 123 ACE inhibitor-exposed controls
867 European ancestry ACE inhibitor-exposed cases, 4,364 European ancestry ACE inhibitor-exposed controls
580 European ancestry cases, 39 European ancestry controls
689 European ancestry cases, 41 European ancestry controls
1,434 Han Chinese ancestry cases, 10,661 Han Chinese ancestry controls
6,879 Han Chinese ancestry cases, 9,019 Han Chinese ancestry controls
Bone mineral accretion in asthma (oral corticosteroid dose interaction)
489 European ancestry children
46,553 European ancestry individuals
34,433 European ancestry individuals, 5,605 Han Chinese ancestry individuals
Response to simvastatin treatment (PCSK9 protein level change)
562 European ancestry individuals
287 African American individuals
Epilepsy and lamotrigine-induced maculopapular eruptions
34 Korean ancestry cases, 1,080 Korean ancestry healthy controls
130 Korean ancestry cases, 1,081 Korean ancestry controls
16,843 Japanese ancestry individuals, 19,509 European ancestry individuals, 16,388 African American individuals
9,802 Japanese ancestry individuals, 16,550 European ancestry individuals, 7,391 African American individuals
9,810 Japanese ancestry individuals, 16,550 European ancestry individuals, 7,369 African American individuals
Hearing function (high tone)
2,155 Italian (founder/genetic isolate) individuals
481 Silk Road (founder/genetic isolate) individuals, 270 European ancestry individuals
Affymetrix, Illumina [up to 38020975] (imputed)
Hearing function (0.25 kHz)
Hearing function (0.5 kHz)
Hearing function (1 kHz)
481 Silk Road (founder/genetic isolate) individuals, 6,162 European ancestry individuals
Hearing function (2 kHz)
Hearing function (4 kHz)
Hearing function (8 kHz)
Hearing function (low tone)
Hearing function (medium tone)
3,294 Japanese ancestry individuals
6,065 Japanese ancestry individuals
6,406 European ancestry cases, 601 African American cases, 288 East Asian ancestry cases, 488 Latino cases30,866 European ancestry controls, 1,650 African American controls, 2,938 East Asian ancestry controls, 3,141 Latino controls
4,599 European ancestry cases, 2,265 African American cases, 2,940 European ancestry controls, 2,414 African American controls
2,109 Japanese ancestry cases, 11,140 Japanese ancestry controls
2,223 East Asian ancestry cases, 4,724 East Asian ancestry controls
Cryptorchidism
844 European ancestry cases, 2,718 European ancestry controls
298 European ancestry cases, 324 European ancestry controls
Sight-threatening diabetic retinopathy in type 2 diabetes
336 European ancestry cases with retinopathy, 508 European ancestry cases without retinopathy
263 European ancestry cases with retinopathy, 320 European ancestry cases without retinopathy, 334 South Asian ancestry cases with retinopathy, 365 South Asian ancestry cases without retinopathy
Hypersomnia during a major depressive episode in bipolar disorder
263 European ancestry cases with hypersomnia, 112 European ancestry cases without hypersomnia
Atrioventricular septal defects in Down syndrome
210 European ancestry cases with atrioventricular septal defects, 242 European ancestry cases with normal hearts
Multiple myeloma (survival)
469 European ancestry cases, 25 African American cases, 27 Latino cases, 24 cases
1090 European ancestry cases
Affymetrix, Illumina [6026834] (imputed)
1,511 African American cases, 1,797 African American controls
1,088 African American cases, 1,797 African American controls
361 African American cases, 1,797 African American controls
Susceptibility to persistent hepatitis B virus infection
1,251 Chinese ancestry persistently infected cases, 1,057 Chinese ancestry spontaneously recovered controls
3,905 Chinese ancestry persistently infected cases, 3,356 Chinese ancestry spontaneously recovered controls
Affymetrix, Illumina [up to 4494311] (imputed)
Carotid artery external diameter
3,681 individuals
Carotid artery internal diameter
Carotid artery stiffness
Carotid artery intima media thickness
Carotid artery mean blood pressure
Carotid artery central pulse pressure
Targeted genotyping array [Illumina HumanExome-12v1.1 BeadChip]
Carotid artery circumferential wall stress
Carotid artery wall cross sectional area
Colorectal cancer (alcohol consumption interaction)
8,058 European ancestry non/occasional, light-to-moderate, and heavy drinker cases, 8,765 European ancestry non/occasional, light-to-moderate, and heavy drinker controls
Colorectal cancer (smoking interaction)
11,219 European ancestry ever-smoker and never-smoker cases, 11,382 European ancestry ever-smoker and never-smoker controls
Joint damage in rheumatoid arthritis
666 Mexican ancestry cases, 407 European ancestry cases
Breast milk fatty acid composition (maternal genotype effect)
1,142 Bangladeshi ancestry (non-array genotyped, whole-genome imputed) mothers
Breast milk fatty acid composition (infant genotype effect)
1,142 Bangladeshi ancestry infants
up to 77,898 European ancestry individuals, up to 7,695 African American individuals
up to 111,874 European ancestry individuals
77,898 European ancestry individuals
7,695 African American individuals
1,541 African American alcohol dependent cases, 1,436 European American alcohol dependent cases, 632 African American non-alcohol dependent controls, 315 European American non-alcohol dependent controls
24,087 European ancestry cases, 55,058 European ancestry controls
47,793 European ancestry cases, 328,320 European ancestry controls
24,087 European ancestry late-onset Alzheimer's disease cases, 47,793 European ancestry individuals with family history of Alzheimer's disease, 383,378 European ancestry controls
Affymetrix, Illumina [up to 10847151] (imputed)
Fast beta electroencephalogram
1,564 European ancestry individuals from 117 alcohol dependence affected families
2,134 European ancestry cases, 9,125 European ancestry controls
Cisplatin-induced ototoxicity
511 European ancestry testicular cancer survivor individuals
238 children
1,825 African American ancestry cases, 3,784 African American ancestry controls
IgG glycosylation patterns
1,823 European ancestry individuals
1,836 European ancestry individuals
212 European ancestry cases, 173 Chinese ancestry cases, 122 Korean ancestry cases, 202 European ancestry controls, 615 Chinese ancestry controls, 374 Korean ancestry controls
Affymetrix, Illumina [at least 6512116] (imputed)
2,382 African American individuals
134,070 European ancestry individuals, 143,658 East Asian ancestry individuals, 26,344 Hispanic or Latino ancestry individuals, 8,224 African American individuals
Affymetrix, Illumina [at least 5248638] (imputed)
157,039 European ancestry cases, 206,666 European ancestry controls
Vitiligo (late onset)
1,467 European ancestry cases, 19,156 European ancestry controls
977 European ancestry cases, 727 European ancestry controls
Vitiligo (early onset)
704 European ancestry cases, 9,031 European ancestry controls
375 European ancestry cases, 1,455 European ancestry controls
Brain glucose metabolism (fluorodeoxyglucose uptake)
37 European ancestry Alzheimer's disease cases, 126 European ancestry individuals with mild cognitive impairment, 59 European ancestry controls
Bone mineral density x blood lead interaction in current smokers (2df test)
119 Korean ancestry current smokers
Bone mineral density x blood lead interaction in current smokers (1df test)
Change in glucose in response to thiazide diuretic treatment in hypertension
135 African American individuals, 175 European ancestry individuals
140 African American individuals, 222 European ancestry individuals
1,009 French Canadian cases, 1,017 French Canadian controls
1,391 European ancestry cases, 352,195 European ancestry controls
6,527 European ancestry cases, 45,882 European ancestry controls
481 Latino cases, 398 East Asian ancestry cases, 146 African American cases, 5,215 Latino controls, 5,040 East Asian ancestry controls, 2,133 African American controls
Broad depression or major depressive disorder (self-reported)
9,240 European ancestry broad depression cases, 9,519 European ancestry broad depression controls, 51,258 European ancestry individuals, 75,607 European ancestry self-reported major depressive disorder cases, 231,747 European ancestry self-reported major depressive disorder controls
322,580 individuals
Affymetrix, Illumina [at least 918921] (imputed)
Broad depression or major depressive disorder (recurrent)
9,240 European ancestry broad depression cases, 9,519 European ancestry broad depression controls, 51,258 European ancestry individuals, 5,303 Chinese ancestry recurrent major depressive disorder cases, 5,337 Chinese ancestry recurrent major depressive disorder controls
Broad depression or bipolar disorder
9,240 European ancestry broad depression cases, 9,519 European ancestry broad depression controls, 51,258 European ancestry individuals, 7,481 European ancestry bipolar disorder cases, 9,250 European ancestry bipolar disorder controls
Broad depression or schizophrenia
9,240 European ancestry broad depression cases, 9,519 European ancestry broad depression controls, 51,258 European ancestry individuals, 36,989 European and East Asian ancestry schizophrenia cases, 113,075 European and East Asian ancestry schizophrenia controls
Nonobstructive coronary artery disease
332 European ancestry female cases, 1,003 European ancestry female controls
50 Chinese Han ancestry cases, 50 Chinese Han ancestry uterine myoma or hydrosalpinx controls
1,466 Chinese Han ancestry cases, 1,410 Chinese Han ancestry uterine myoma or hydrosalpinx controls
52,506 European ancestry individuals, 12,874 European ancestry cases, 23,203 European ancestry controls
Affymetrix, Illumina [7850345] (imputed)
52,506 European ancestry individuals
Affymetrix, Illumina [up to 31337615] (imputed)
36,948 European ancestry cases, 30,864 European ancestry controls
12,952 European ancestry cases, 48,383 European ancestry controls, 8,580 East Asian ancestry cases, 13,050 East Asian ancestry controls, 1,611 Hispanic cases, 4,330 Hispanic controls, 1,894 African American cases, 4,703 African American controls
Affymetrix, Illumina [12931465] (imputed)
40,585 European ancestry cases, 406,111 European ancestry controls, 17,369 East Asian ancestry cases, 28,195 East Asian ancestry controls, 2,437 South Asian ancestry cases, 6,707 South Asian ancestry controls, 5,541 African American cases, 15,154 African American controls, 365 Asian ancestry cases, 333 Asian ancestry controls, 865 Latin American cases, 692 Latin American controls
40,585 European ancestry cases, 406,111 European ancestry controls
4,373 European ancestry cases, 406,111 European ancestry controls
34,217 European ancestry cases, 406,111 European ancestry controls
4,373 European ancestry cases, 406,111 European ancestry controls, 1,626 East Asian ancestry cases, 28,195 East Asian ancestry controls, 355 South Asian ancestry cases, 6,707 South Asian ancestry controls, 259 African American cases, 15,146 African American controls, 34 Asian ancestry cases, 333 Asian ancestry controls, 41 Latin American cases, 692 Latin American controls
Ischemic stroke (small-vessel)
5,386 European ancestry cases, 192,662 European ancestry controls, 5,096 East Asian ancestry cases, 28,195 East Asian ancestry controls, 314 South Asian ancestry cases, 6,707 South Asian ancestry controls, 694 African American cases, 15,146 African American controls, 134 Asian ancestry cases, 333 Asian ancestry controls, 86 Latin American cases, 692 Latin American controls
7,193 European ancestry cases, 406,111 European ancestry controls, 847 East Asian ancestry cases, 28,195 East Asian ancestry controls, 422 South Asian ancestry cases, 6,707 South Asian ancestry controls, 414 African American cases, 15,146 African American controls, 31 Asian ancestry cases, 333 Asian ancestry controls, 99 Latin American cases, 692 Latin American controls
34,217 European ancestry cases, 406,111 European ancestry controls, 17,369 East Asian ancestry cases, 28,195 East Asian ancestry controls, 2,437 South Asian ancestry cases, 6,707 South Asian ancestry controls, 5,541 African American cases, 15,146 African American controls, 222 Asian ancestry cases, 333 Asian ancestry controls, 555 Latin American cases, 692 Latin American controls
5,386 European ancestry cases, 192,662 European ancestry controls
7,193 European ancestry cases, 406,111 European ancestry controls
914 Sub-Saharan African ancestry cases, 2,159 Sub-Saharan African ancestry controls
401 Sub-Saharan African ancestry cases, 121 African American cases, 648 Sub-Saharan African ancestry controls, 186 African American controls
205 Sub-Saharan African ancestry cases, 2,159 Sub-Saharan African ancestry controls
100 Sub-Saharan African ancestry cases, 79 African American cases, 648 Sub-Saharan African ancestry controls, 186 African American controls
Maximum habitual alcohol consumption
126,936 European ancestry individuals, 17,029 African American individuals
at least 18,538 European ancestry cases, at least 340,302 European ancestry controls
31,787 European ancestry cases, 619,351 European ancestry controls
Affymetrix, Illumina [up to 9061544] (imputed)
9,674 European ancestry cases, 625,657 European ancestry controls
4,120 Spanish ancestry cases, 11,999 cases, 3,289 Spanish ancestry controls, 9,236 controls
1,943 Spanish ancestry cases, 3,016 Spanish ancestry controls
4,120 Spanish ancestry cases, 17,008 cases, 3,289 Spanish ancestry controls, 37,154 controls
1,943 Spanish ancestry cases, 8,572 cases, 3,016 Spanish ancestry controls, 11,312 controls
4,120 European ancestry cases, 3,289 European ancestry controls
Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD+)
1,168 Spanish ancestry cases, 3,289 Spanish ancestry controls
Alzheimer’s disease (clinical subgroup AD+)
3,797 Spanish ancestry cases, 3,289 Spanish ancestry controls
Alzheimer’s disease (clinical subgroup AD++)
2,611 Spanish ancestry cases, 3,289 Spanish ancestry controls
Alzheimer’s disease (clinical subgroup AD+++)
1,854 Spanish ancestry cases, 3,289 Spanish ancestry controls
Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++)
373 Spanish ancestry cases, 3,289 Spanish ancestry controls
Triacylglycerol 56:6 levels
1,937 individuals
Affymetrix, Illumina [up to 22000000] (imputed)
Malate levels
Niacinamide levels
Sphingomyelin 24:0 levels
Uridine levels
Triacylglycerol 56:2 levels
Xanthine levels
Metabolite risk score for predicting weight gain
Childhood dental caries in primary teeth
6,922 European ancestry cases, 10,115 European ancestry controls, 7,530 cases, 11,473 controls
Affymetrix, Illumina [at least 8640819] (imputed)
Childhood dental caries in permanent teeth
5,875 cases, 7,478 controls
Affymetrix, Illumina [8734121] (imputed)
2,701 European ancestry men, 3,275 European ancestry women
2,701 European ancestry men
3,275 European ancestry women
Colorectal cancer or advanced adenoma
55,105 European ancestry cases, 3,026 East Asian ancestry cases, 65,079 European ancestry controls, 2,268 East Asian ancestry controls
Affymetrix, Illumina [16900397] (imputed)
244 European ancestry cases, 2,552 European ancestry controls, 56 African cases, 454 African controls, 85 Maghrebian cases, 261 Maghrebian controls
132 European ancestry cases, 2,000 European ancestry controls
56 African cases, 454 African controls
85 Maghrebian cases, 261 Maghrebian controls
5,643 Korean ancestry individuals
1,926 Korean ancestry individuals
Forehead morphology
up to 1,940 Korean ancestry individuals
Upper eyelid morphology
Response to SSRI (symptom improvement)
1,828 European ancestry individuals
1,472 European ancestry individuals
Affymetrix, Illumina [7062950] (imputed)
Response to antidepressants (symptom improvement)
2,145 European ancestry individuals
Response to SSRI (symptom remission)
Response to antidepressants (symptom remission)
Familial lung cancer
1,993 European ancestry cases, 33,960 European ancestry controls
Familial lung adenocarcinoma
775 European ancestry cases, 31,563 European ancestry controls
Familial squamous cell lung carcinoma
367 European ancestry cases, 31,563 European ancestry controls
11,822 Hispanic individuals
up to 4,162 Hispanic individuals, up to 876 African American individuals, up to 94,612 European ancestry individuals
854 Hispanic cases, 9,549 Hispanic controls
European ancestry individuals (see Wilk et al 2012)
363 Hispanic cases, 5,253 Hispanic controls
European ancestry cases and controls (see Wilk et al 2012)
66,310 British ancestry females
117,626 European ancestry males, 144,471 European ancestry females
Age at first sexual intercourse
59,357 British ancestry males, 66,310 British ancestry females
Empathy quotient
22,318 European ancestry males, 24,543 European ancestry females
Plasma trimethyllysine levels
1,297 European ancestry individuals
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)
up to 488 European ancestry cases, up to 111 African American cases, up to 60 Hispanic cases, up to 56 other ancestry cases
Possible neuropathic pain in post total joint replacement surgery for osteoarthritis
109 cases, 504 controls.
3,596 Latino individuals
941 Latino individuals
100,234 British ancestry individuals
Suicidality (suicidal ideation/attempts)
108,090 British ancestry individuals
Suicidality
122,808 British ancestry individuals
256 Ashkenazi Jewish cases, 68 African American cases, 534 Ashkenazi Jewish controls, 217 African American controls
Affymetrix, Illumina [up to 1101633] (imputed)
2,433 British ancestry cases, 334,766 British ancestry controls
Predicted suicide risk
24,546 European ancestry individuals
1,211 Korean ancestry female cases, 639 Korean ancestry female controls
1,065 Korean ancestry female cases, 1,053 Korean ancestry female controls
4,659 Korean ancestry females
5,273 Korean ancestry females
up to 2,857 Korean ancestry male cases and male controls
16,759 Singaporean Han Chinese ancestry individuals
6,337 Singaporean Chinese ancestry individuals, up to 37,505 European ancestry individuals
Serum bilirubin levels in metabolic syndrome
188 European ancestry male individuals, 242 European ancestry female individuals
Serum bilirubin levels x sex interaction in metabolic syndrome
Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome
257 European ancestry individuals with low adherence to Mediterranean diet, 161 European ancestry individuals with high adherence to Mediterranean diet
1,576 European ancestry individuals, 134 African American individuals, 81 Hispanic individuals, 38 individuals
1,307 European ancestry individuals, 722 European breast cancer cases, 693 European ancestry controls, 120 African-American individuals, 38 African American breast cancer cases, 46 African American controls, 59 Hispanic individuals, 27 Hispanic breast cancer cases, 27 Hispanic controls, 47 individuals, 23 breast cancer cases, 14 controls
Esophageal adenocarcinoma x BMI interaction
2,284 European ancestry cases, 2,182 European ancestry controls
Esophageal adenocarcinoma x smoking interaction
Esophageal adenocarcinoma x pack-years of smoking exposure interaction
Esophageal adenocarcinoma x gastroesophageal reflux disease interaction
Barrett's esophagus x BMI interaction
3,104 European ancestry cases, 2,182 European ancestry controls
Barrett's esophagus x pack-years of smoking exposure interaction
Barrett's esophagus x smoking interaction
Barrett's esophagus x gastroesophageal reflux disease interaction
Multiple sclerosis and systolic blood pressure (pleiotropy)
230,204 individuals
Multiple sclerosis and body mass index (pleiotropy)
151,013 individuals
Multiple sclerosis and waist-to-hip-ratio (pleiotropy)
104,315 individuals
Multiple sclerosis and type 2 diabetes (pleiotropy)
49,192 individuals
Multiple sclerosis and C-reactive protein levels (pleiotropy)
93,333 individuals
Multiple sclerosis and triglyceride levels (pleiotropy)
215,725 individuals
Multiple sclerosis and LDL levels (pleiotropy)
Multiple sclerosis and HDL levels (pleiotropy)
Atopic march
1,151 European ancestry early-onset eczema and childhood asthma cases, 10,030 European ancestry controls
1,277 European ancestry early-onset eczema and childhood asthma cases, 7,004 European ancestry controls
Affymetrix, Illumina [1633153] (imputed)
2,672 cases
99 Korean ancestry cases with intestinal involvement, 100 Korean ancestry cases without intestinal involvement, 597 Korean ancestry controls.
196 Korean ancestry cases with intestinal involvement, 138 Korean ancestry cases without intestinal involvement, 391 Korean ancestry controls.
1,762 Northern European ancestry poor prognosis cases, 972 Northern European ancestry good prognosis controls.
Affymetrix, Illumina [at least 7000000] (imputed)
Angiotensin-converting enzyme inhibitor intolerance
972 European ancestry intolerant individuals, 4,189 European ancestry tolerant individuals
Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities)
90,667 European ancestry individuals
Moderate to vigorous physical activity levels
377,234 European ancestry individuals
Vigorous physical activity
98,060 European ancestry active cases, 162,995 European ancestry inactive controls
Strenuous sports or other exercises
124,842 European ancestry active cases, 225,650 European ancestry inactive controls
Accelerometer-based physical activity measurement (average acceleration)
91,084 European ancestry individuals
Depressive symptom measurement or major depressive disorder
9,240 European ancestry cases, 9,519 European ancestry controls, 51,150 European ancestry individuals with depressive symptom measurement
6,879 European ancestry cases, 13,453 European ancestry controls, 5,303 Chinese ancestry cases, 5,337 Chinese ancestry controls, 8,157 European American individuals with depressive symptom measurement
Affymetrix, Illumina, Perlegen [918921] (imputed)
Alzheimer's disease in hypertension-negative individuals
796 European ancestry cases, 4,010 European ancestry controls
Alzheimer's disease in hypertension
1,262 European ancestry cases, 9,608 European ancestry controls
Antipsychotic drug-induced QTc interval change in schizophrenia
434 European ancestry individuals, 202 African ancestry individuals, 25 individuals
Affymetrix, Perlegen [1785543] (imputed)
2,457 Icelandic ancestry cases, 349,342 Icelandic ancestry controls (including non-array genotyped, whole genome imputed individuals)
4,850 European ancestry cases, 451,731 European ancestry controls
Severe progression in rheumatoid arthritis
120 Korean ancestry cases, 118 Korean ancestry controls
Normal facial asymmetry (angle of surface orientation score)
3,186 European ancestry individuals
Normal facial asymmetry (angle of deformation score)
Normal facial asymmetry (deformation magnitude)
11 Taiwanese ancestry cases, 146 Taiwanese ancestry controls
Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction)
up to 825 European ancestry case-parent trios, up to 1,024 Asian ancestry case-parent trios, up to 59 case-parent trios
Cleft lip with or without cleft palate (maternal periconceptional cigarette smoking interaction)
Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction)
Virologic severity in Herpes simplex virus type 2 infection
223 European ancestry individuals
3,869 European ancestry 50% oldest-onset cases, 5,051 European ancestry cases, 2,691 European ancestry controls, 6,828 unknown controls
6,107 European ancestry, Han Chinese ancestry and unknown ancestry 50% oldest-onset cases, 7,131 European ancestry, Han Chinese ancestry and unknown ancestry cases, 104,402 European ancestry controls, 5,537 Han Chinese ancestry controls, 14,291 unknown ancestry controls
Lichen planus in hepatitis C
71 Japanese ancestry cases, 190 Japanese ancestry controls
38 Italian ancestry cases, 7 Italian ancestry controls
Serum metabolite concentrations in chronic kidney disease
1,143 European ancestry cases
Urinary metabolite ratios in chronic kidney disease
Serum metabolite ratios in chronic kidney disease
Fractional excretion of metabolites in chronic kidney disease
Gait speed in old age
31,478 European ancestry older adults
2,588 European ancestry older adults
123 European ancestry cases, 1,345 European and unknown ancestry controls, 1 Middle Eastern ancestry case
Remission after antidepressant treatment in major depression
119 European ancestry remitters and non-remitters
112 European ancestry responders, 98 European ancestry non-responders
Bitter taste perception (multivariate analysis)
1,999 European ancestry individuals from 929 twin families
Surgical necrotising enterocolitis in extremely premature birth
20 African American cases, 6 Hispanic Caucasian cases, 4 European ancestry cases, 283 African American controls, 130 Hispanic Caucasian controls, 133 European ancestry controls,
96 European ancestry cases, 96 European ancestry heparin-exposed controls
86 European ancestry cases, 86 European ancestry heparin-exposed controls
2,158 Irish ancestry individuals
55,114 European ancestry cases, 482,295 European ancestry controls, 8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls, 1,307 African American ancestry cases, 7,660 African American ancestry controls, 845 Hispanic cases, 4,177 Hispanic controls
Affymetrix, Illumina [up to 12149979] (imputed)
14,085 European ancestry cases, 76,768 European ancestry controls
25,685 European ancestry allergic diseases cases, 76,768 European ancestry controls
Asthma or allergic disease (pleiotropy)
14,085 European asthma cases, 25,685 European ancestry allergic diseases cases, 76,768 European ancestry controls
49,269 European ancestry individuals
up to 22,383 European ancestry individuals
Affymetrix, Illumina [8048941] (imputed)
54,288 European ancestry individuals
3,340 European ancestry cases, 49,983 European ancestry controls
Affymetrix, Illumina [5965951] (imputed)
Hyperthyroidism
1,840 European ancestry cases, 49,983 European ancestry controls
Hematoma volume in lobar spontaneous intracerebral hemorrhage
228 European ancestry cases
71 European ancestry cases
Hematoma volume in non-lobar spontaneous intracerebral hemorrhage
166 European ancestry cases
169 European ancestry cases
116,666 British ancestry individuals
Oxygen saturation of hemoglobin levels
921 Tibetan ancestry individuals
Oxygenated hemoglobin levels
920 Tibetan ancestry individuals
Deoxygenated hemoglobin levels
Child death (Number of children surviving at 1 year but died <5 years)
849 Tibetan ancestry individuals
Child death in continuous marriage (Number of children surviving at 1 year but died <5 years)
593 Tibetan ancestry individuals
Child survival (Number of children surviving at 5 years)
Child survival in continuous marriage (Number of children surviving at 5 years)
Child death (Proportion of children surviving at 1 year but died <5 years)
Child death in continuous marriage (Proportion of children surviving at 1 year but died <5 years)
Child survival (Proportion of children surviving at 5 years)
Child survival in continuous marriage (Proportion of children surviving at 5 years)
Juvenile death (Number of children surviving at 5 years but died <15 years)
531 Tibetan ancestry individuals
Juvenile death in continuous marriage (Number of children surviving at 5 years but died <15 years)
up to 531 Tibetan ancestry individuals
Juvenile death (Proportion of children surviving at 5 years but died <15 years)
Juvenile death in continuous marriage (Proportion of children surviving at 5 years but died <15 years)
Juvenile survival (Number of children surviving at 15 years)
Juvenile survival in continuous marriage (Number of children surviving at 15 years)
Juvenile survival (Proportion of children surviving at 15 years)
Juvenile survival in continuous marriage (Proportion of children surviving at 15 years)
Number of live births
981 Tibetan ancestry individuals
Number of live births in continuous marriage
Proportion of live births
Proportion of live births in continuous marriage
Infant death in continuous marriage (Proportion of children died <1 year)
Infant and Child death (Number of children died <5 years)
Infant and Child death in continuous marriage (Number of children died <5 years)
Infant and Child death (Proportion of children died <5 years)
Infant and Child death in continuous marriage (Proportion of children died <5 years)
Infant, child and juvenile death (number of children died <15 years)
532 Tibetan ancestry individuals
Infant, child and juvenile death in continuous marriage (number of children died <15 years)
up to 532 Tibetan ancestry individuals
Infant, child and juvenile death (proportion of children died <15 years)
Infant, child and juvenile death in continuous marriage (proportion of children died <15 years)
Infant death (Number of children died <1 year)
923 Tibetan ancestry individuals
Infant death in continuous marriage (Number of children died <1 year)
Infant death (Proportion of children died <1 year)
Infant survival (Number of children surviving at 1 year)
Infant survival in continuous marriage (Number of children surviving at 1 year)
Infant survival (Proportion of children surviving at 1 year)
Infant survival in continuous marriage (Proportion of children surviving at 1 year)
Number of miscarriages
Number of miscarriages in continuous marriage
Proportion of miscarriages
Proportion of miscarriages in continuous marriage
Number of stillbirths
Number of stillbirths in continuous marriage
Proportion of stillbirths
Proportion of stillbirths in continuous marriage
23,877 European ancestry cases, 562,153 European ancestry controls
Affymetrix, Illumina [11554240] (imputed)
17,151 European ancestry cases, 596,639 European ancestry controls
Number of pregnancies in continuous marriage
Number of twin births in continuous marriage
Age at last pregnancy
958 Tibetan ancestry individuals
Age at last pregnancy in continuous marriage
972 Tibetan ancestry individuals
Age at first birth in continuous marriage
1,005 Han Chinese ancestry cases, 1,257 Han Chinese ancestry controls
1,378 Han Chinese ancestry cases, 3,774 Han Chinese ancestry controls
Attention deficit hyperactivity disorder or cannabis use
18,345 European ancestry ADHD cases, 14,374 European ancestry cannabis use cases, 50,410 European ancestry controls
Infliximab-induced mucosal healing in Crohn's disease
15 Korean ancestry responders, 43 Korean ancestry non-responders
27 Korean ancestry responders, 27 Korean ancestry non-responders
2,763 individuals
327 Arab, South Asian and Filipino ancestry individuals, 294 European ancestry individuals, 591 individuals.
Dentate gyrus volume x schizophrenia interaction
88 European ancestry cases, 22 Black or African American cases, 18 Asian ancestry cases, 1 American Indian or Alaskan Native ancestry case, 1 Native Hawaiian or Pacific Islander ancestry case, 111 European ancestry controls, 18 Black or African American controls, 13 Asian ancestry controls, 2 American Indian or Alaskan Native ancestry controls, 1 Native Hawaiian or Pacific Islander ancestry control
Dentate gyrus volume
199 European ancestry individuals, 40 Black or African American individuals, 31 Asian ancestry individuals, 3 American Indian or Alaskan Native ancestry individuals, 2 Native Hawaiian or Pacific Islander ancestry individuals
522 European ancestry JIA cases, 398 European ancestry controls
Uveitis (juvenile idiopathic arthritis-associated)
192 European ancestry JIA-associated uveitis cases, 398 European ancestry controls
Uveitis in juvenile idiopathic arthritis
192 European ancestry JIA-associated uveitis cases, 330 European ancestry controls
Parental longevity (combined parental attained age, Martingale residuals)
389,166 British ancestry individuals
Parental longevity (both parents in top 10%)
7,182 cases, 79,767 controls
246,941 British ancestry individuals
Parental longevity (mother's attained age)
412,937 British ancestry individuals
317,652 British ancestry individuals
Parental longevity (father's attained age)
415,311 British ancestry individuals
208,118 British ancestry individuals
Fatty acid desaturase activity (serum)
1,453 European ancestry individuals
Fatty acid desaturase activity (adipose tissue)
783 European ancestry individuals
999 cases, 2,031 controls
at least 2,232 European ancestry cases, at least 140,725 European ancestry controls, 2,597 Hispanic cases, 9,378 Hispanic controls, 710 cases, 1,122 controls
Estimated glomerular filtration rate in diabetes
70,762 European ancestry individuals, 20,967 African American individuals
Estimated glomerular filtration rate in non-diabetics
152,624 European ancestry individuals, 36,369 African American individuals
70,762 European ancestry diabetic individuals, 152,624 European ancestry non-diabetic individuals, 20,967 African American diabetic individuals, 36,369 African American non-diabetic individuals
567,401 European ancestry individuals, 165,726 East Asian ancestry individuals, 13,359 South Asian ancestry individuals, 13,842 African American ancestry individuals, 4,961 Hispanic ancestry individuals
Treatment resistant depression
1,378 European ancestry treatment resistant cases, 934 European ancestry responders to first treatment, 914 European ancestry non-responders to first treatment
Affymetrix, Illumina [7000000] (imputed)
1,378 European ancestry treatment resistant cases, 934 European ancestry responders to first treatment
Depressive symptom improvement
11,569 European ancestry cases, 34,999 European ancestry controls, 3,335 African American cases, 2,945 African American controls
1,232 European ancestry cases, 22,614 European ancestry controls, 1,791 African American cases, 2,413 African American controls
Bone mineral density (lumbar spine) in inflammatory bowel disease
254 Japanese ancestry cases
Bone mineral density (femoral neck) in inflammatory bowel disease
PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia
59 European ancestry cases, 772 European ancestry controls
Silent asparaginase inactivation in childhood acute lymphoblastic leukaemia
32 European ancestry cases, 772 European ancestry controls
PEG-asparaginase hypersensitivity in childhood acute lymphoblastic leukaemia (allergic reaction grade 2 or more)
106 European ancestry cases, 772 European ancestry controls
Facial morphology (factor 1, breadth of lateral portion of upper face)
2,187 European ancestry individuals
Facial morphology (factor 10, width of nasal floor)
Facial morphology (factor 3, length of philtrum)
Facial morphology (factor 15, philtrum width)
Facial morphology (factor 16)
Facial morphology (factor 17, height of vermillion upper lip)
Facial morphology (factor 18)
Facial morphology (factor 19)
Facial morphology (factor 20)
Facial morphology (factor 2, vertical position of orbits relative to midface)
Facial morphology (factor 4, facial height related to vertical position of gnathion)
Facial morphology (factor 5, width of mouth relative to central midface)
Facial morphology (factor 6, height of vermillion lower lip)
Facial morphology (factor 7, width of cartilaginous portion of nose)
Facial morphology (factor 8, orbital inclination due to vertical and horizontal position of exocanthion)
Facial morphology (factor 9, facial height related to vertical position of nasion)
Facial morphology (factor 11, projection of the nose)
Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface)
Facial morphology (factor 13, vertical position of alar curvature relative to upper lip)
Facial morphology (factor 14, intercanthal width)
Facial morphology (factor 21, depth of nasal alae)
Facial morphology (factor 22)
Facial morphology (factor 23)
up to 58,799 European ancestry adults, up to 19,509 European ancestry children
Affymetrix, Illumina [12104294] (imputed)
Left ventricular function change in anthracycline treatment
337 European ancestry individuals, 30 African American individuals, 1 Asian individual, 4 Latino individuals, 13 individuals
152 European ancestry individuals, 23 African American individuals, 3 Asian individuals, 3 individuals
Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction)
2,518 African American women, 83,707 European ancestry women, 1,773 Filipino ancestry women, 1,030 Indian ancestry women, 1,457 African American men, 52,993 European ancestry men, 7,648 Indian ancestry men, 5,527 European ancestry individuals
6,244 African American women, 17,531 European ancestry women, 329 African American men, 19,956 European ancestry men
2,518 African American women, 86,278 European ancestry women, 1,773 Filipino ancestry women, 1,030 Indian ancestry women, 1,457 African American men, 55,137 European ancestry men, 7,648 Indian ancestry men, 5,527 European ancestry individuals
2,518 African American women, 85,730 European ancestry women, 1,773 Filipino ancestry women, 1,030 Indian ancestry women, 1,457 African American men, 54,792 European ancestry men, 7,648 Indian ancestry men, 5,527 European ancestry individuals
Body mass index (physical activity interaction)
Waist circumference adjusted for BMI (physical activity interaction)
Waist-to-hip ratio adjusted for BMI (physical activity interaction)
Body mass index (joint analysis main effects and physical activity interaction)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction)
Body mass index in physically active individuals
1,957 African American women, 1,773 Filipino ancestry women, 305 Indian ancestry women, 67,609 European ancestry women, 1,206 African American men, 2,029 Indian ancestry men, 43,399 European ancestry men, at least 4,819 European ancestry individuals
4,807 African American women, 12,347 European ancestry women, 265 African American men, 14,540 European ancestry men
Body mass index in physically inactive individuals
561 African American women, 352 Filipino ancestry women, 725 Indian ancestry women, 19,366 European ancestry women, 251 African American men, 4,654 Indian ancestry men, 11,727 European ancestry men, 959 European ancestry individuals
1,437 African American women, 5,184 European ancestry women, 64 African American men, 5,416 European ancestry men
Waist circumference adjusted for BMI in active individuals
1,957 African American women, 1,773 Filipino ancestry women, 305 Indian ancestry women, 67,139 European ancestry women, 1,206 African American men, 2,029 Indian ancestry men, 43,100 European ancestry men, at least 4,819 European ancestry individuals
Waist circumference adjusted for BMI in inactive individuals
561 African American women, 352 Filipino ancestry women, 725 Indian ancestry women, 19,288 European ancestry women, 251 African American men, 4,654 Indian ancestry men, 11,681 European ancestry men, 959 European ancestry individuals
Waist-to-hip ratio adjusted for BMI in active individuals
1,957 African American women, 1,421 Filipino ancestry women, 305 Indian ancestry women, 65,539 European ancestry women, 1,206 African American men, 2,029 Indian ancestry men, 41,673 European ancestry men, 4,819 European ancestry individuals
Waist-to-hip ratio adjusted for BMI in inactive individuals
561 African American women, 352 Filipino ancestry women, 725 Indian ancestry women, 18,865 European ancestry women, 251 African American men, 4,654 Indian ancestry men, 11,309 European ancestry men, 959 European ancestry individuals
767 Oceanian ancestry cases, 1,462 Oceanian ancestry controls, 168 Fijian Indian cases, 151 Fijian Indian controls, 71 mixed and other ancestry cases, 236 mixed and other ancestry controls
3,495 European ancestry cases, 10,982 European ancestry controls
Up to 31,155 African individuals
Up to 4,187 African individuals, up to 14,016 Korean ancestry individuals, up to 23,914 European ancestry individuals, up to 12,278 Hispanic individuals
Affymetrix, Illumina [at least 30072738] (imputed)
18,440 African individuals
2,375 African individuals, 3,718 Korean ancestry individuals, 9,348 European ancestry individuals, 3,445 Hispanic individuals
Blood pressure traits (multi-trait analysis)
23,104 European ancestry non-drinker individuals, 47,967 European ancestry drinker individuals, 2,673 Hispanic/Latino non-drinker individuals, 4,374 Hispanic/Latino drinker individuals, 3,288 East Asian ancestry non-drinker individuals, 2,746 East Asian ancestry drinker individuals, 1,165 African American non-drinkers individuals, 1,310 African American drinker individuals.
Elevated serum prostate-specific antigen levels in healthy men
2,841 Korean ancestry individuals
1,283 Korean ancestry individuals
Venlafaxine response in generalised anxiety disorder (HAMA-A score reduction after 24 weeks)
98 European ancestry individuals
Venlafaxine response in generalised anxiety disorder (HAMA-A score reduction after 12 weeks)
Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 12 weeks)
98 European ancestry cases and controls
Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks)
78 European ancestry cases, 20 European ancestry controls
Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 12 weeks)
Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks)
Autism spectrum disorder or schizophrenia
schizophrenia cases and controls (see Ripke, 2014), up to 6,197 European ancestry ASD cases, up to 7,377 European ancestry controls, up to 1,190 ASD cases, up to 1,190 controls
6,197 European ancestry cases, 7,377 European ancestry controls, 1,190 cases, 1,190 controls
8,266 European ancestry cases, 147,562 European ancestry controls, 886 cases, 1,105 controls
Affymetrix, Illumina [6695386] (imputed)
Up to 11,988 European ancestry cases, up to 275,335 European ancestry controls
7,044 European ancestry cases, 11,434 European ancestry controls
14,926 European ancestry cases, 189,715 European ancestry controls, 2,119 Japanese ancestry cases, 2,143 Japanese ancestry controls
Affymetrix, Illumina [up to 6979035] (imputed)
up to 11,809 Hispanic/Latino American individuals
up to 7,200 Hispanic/Latino American individuals
White blood cell count (eosinophil)
White blood cell count (lymphocyte)
White blood cell count (monocyte)
White blood cell count (neutrophil)
1,122 Han Chinese ancestry cases, 4,036 Han Chinese ancestry controls
907 Han Chinese ancestry cases, 2,127 Han Chinese ancestry controls
Bone erosion in rheumatoid arthritis
385 Korean ancestry cases, 326 Korean ancestry controls
Attention deficit hyperactivity disorder and obsessive compulsive disorder
1406 European ancestry obsessive-compulsive disorder cases and 1,592 European ancestry controls from 1065 families, 2,960 European and unknown ancestry attention deficit hyperactivity disorder cases, 2,455 European and unknown ancestry parental and independent controls.
Interleukin-6 (red blood cell fatty acid level interaction)
2,703 individuals
Lipoprotein-associated phospholipase A2 (red blood cell fatty acid level interaction)
Intercellular adhesion molecule 1 (red blood cell fatty acid level interaction)
Cellular adhesion molecule (red blood cell fatty acid level interaction)
Monocyte chemoattractant protein-1 (red blood cell fatty acid level interaction)
Tumor necrosis factor receptor II (red blood cell fatty acid level interaction)
C-reactive protein (red blood cell fatty acid level interaction)
Osteoprotegerin (red blood cell fatty acid level interaction)
P-Selectin (red blood cell fatty acid level interaction)
6-month creatinine clearance change response to tenofovir treatment in HIV infection (concomitant antiretroviral treatment interaction)
243 European American ancestry tenofovir-treated cases, 149 African American tenofovir-treated cases, 100 Hispanic American tenofovir-treated cases, 9 unknown ancestry tenofovir-treated cases, 243 European American ancestry abacavir-treated cases, 189 African American abacavir-treated cases, 102 Hispanic American abacavir-treated cases, 14 unknown ancestry abacavir-treated cases.
Tenofovir clearance in HIV infection (concomitant antiretroviral treatment interaction)
243 European American ancestry cases, 149 African American cases, 100 Hispanic American cases, 9 unknown ancestry cases
Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)
6-month creatinine clearance change response to tenofovir treatment in HIV infection (treatment arm interaction)
Tenofovir clearance in HIV infection
243 European ancestry cases, 149 African American cases, 100 Hispanic American cases, 9 unknown ancestry cases
Bilirubin levels in tenofovir-treated HIV infection
133,903 European ancestry individuals, 6,635 African American individuals, 420 Turkish ancestry individuals, 365 Moroccan ancestry individuals, 395 Surinamese ancestry individuals, 840 Chinese ancestry individuals.
9,799 European ancestry individuals, 1,449 Filipino ancestry individuals.
Affymetrix, Illumina [at least 22434434] (imputed)
133,903 European ancestry individuals
9,799 European ancestry individuals
Amyotrophic lateral sclerosis or schizophrenia (pleiotropy)
10,147 European ancestry amyotrophic lateral sclerosis cases, 34,241 European and Asian ancestry schizophrenia cases, 22,094 European ancestry controls, 45,604 European and Asian ancestry controls
1,345 European ancestry individuals (homozygous for LoF CYPA3A5)
Energy expenditure (24h)
419 Pima Indian ancestry individuals
Resting metabolic rate
509 Pima Indian ancestry individuals
251 French Canadian individuals from 5 families
1,033 European ancestry individuals
12,502 Hispanic/Latino individuals
7,106 Hispanic/Latino individuals
4,772 Hispanic/Latino individuals
2,513 European ancestry individuals
2,171 European ancestry individuals, 772 African American individuals
Affymetrix, Illumina [2473256] (imputed)
Subcutaneous adipose tissue adjusted for BMI
Total adipose tissue adjusted for BMI
1,152 European ancestry males, 1,361 European ancestry females
Total adipose tissue
2,171 European ancestry individuals, 772 African American ancestry individuals
8,050 European ancestry individuals
2,080 European ancestry cases, 6,435 European ancestry controls
781 European ancestry cases, 1,591 European ancestry controls, 896 African American cases, 1,905 African American controls
467 Korean ancestry cases, 1,313 Korean ancestry controls
179 Korean ancestry cases, 500 Korean ancestry controls
Aggressive periodontitis
851 European ancestry cases, 6,836 European ancestry controls
223 cases, up to 564 controls
Obstetric antiphospholipid syndrome
115 Japanese ancestry female cases, 419 Japanese ancestry male and female controls
Peripheral arterial disease (traffic-related air pollution interaction)
104 European ancestry cases, 1,519 European ancestry controls, 34 African American cases, 520 African American controls
1,331 German ancestry cases, 1,934 German ancestry controls
Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis
1,331 German ancestry alcohol dependence cases, 1,110 German ancestry cases with chronic alcoholic pancreatitis, 400 European ancestry cases with alcohol-related liver cirrhosis, 3,684 German ancestry controls
Chronic alcoholic pancreatitis or alcohol-related cirrhosis
1,110 German ancestry cases with chronic alcoholic pancreatitis, 400 European ancestry cases with alcohol-related liver cirrhosis, 1,750 German ancestry controls
29,266 European ancestry cases, 56,450 European ancestry controls
11,273 European ancestry cases, 55,483 European ancestry controls
7,426 European ancestry cases, 55,627 European ancestry controls
Small cell lung carcinoma
2,664 European ancestry cases, 21,444 European ancestry controls
23,223 European ancestry cases, 16,964 European ancestry controls
2,355 European ancestry cases, 7,504 European ancestry controls
4,783 African American men, 15,601 African American women
981 African American men, 1,730 African American women, 104,079 European ancestry men, 116,742 European ancestry women
Affymetrix, Illumina [20502658] (imputed)
Body mass index (adult)
16,559 African ancestry men, 26,193 African ancestry women
2,458 African ancestry men, 7,685 African ancestry women, 152,893 European ancestry men, 171,977 European ancestry women
Affymetrix, Illumina [17972087] (imputed)
Skin aging (microtopography measurement)
5,087 individuals
Peak insulin response
2,337 Hispanic individuals, 2,159 European ancestry individuals, 332 Pima Indian ancestry individuals
739 European ancestry individuals
Affymetrix, Illumina [~ 39000000] (imputed)
Acute insulin response
2,346 Hispanic individuals, 2,087 European ancestry individuals, 332 Pima Indian ancestry individuals
741 European ancestry individuals
Insulin secretion rate
527 European ancestry individuals
2,345 Hispanic individuals, 2,042 European ancestry individuals, 332 Pima Indian ancestry individuals
Insulin disposition index (BMI adjusted)
Peak insulin response (BMI and insulin secretion adjusted)
Peak insulin response (insulin secretion adjusted)
Acute insulin response (insulin secretion and BMI adjusted)
Acute insulin response (insulin secretion adjusted)
insulin secretion rate (BMI adjusted)
vWF levels in ischaemic stroke and hyperhomocysteinaemia
1,931 European and unknown ancestry individuals
Atrial fibrillation (SNPxSNP interaction)
8,173 European ancestry cases, 65,237 European ancestry controls
2,363 European ancestry cases, 114,746 European ancestry controls
Psychosis proneness (hypomanic personality scale)
3,967 Finnish ancestry individuals
Psychosis proneness (perceptual aberration scale)
4,057 Finnish ancestry individuals
Psychosis proneness (revised physical anhedonia scale)
3,988 Finnish ancestry individuals
Psychosis proneness (revised social anhedonia scale)
4,025 Finnish ancestry individuals
Psychosis proneness (hypomanic personality scale and perceptual aberration scale)
3,824 Finnish ancestry individuals
Psychosis proneness (schizoidia scale)
4,191 Finnish ancestry individuals
Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale)
3,787 Finnish ancestry individuals
Psychosis proneness (hypomanic personality scale and revised social anhedonia scale)
3,837 Finnish ancestry individuals
Psychosis proneness (perceptual aberration scale and revised physical anhedonia scale)
3,812 Finnish ancestry individuals
Psychosis proneness (perceptual aberration scale and revised social anhedonia scale)
3,868 Finnish ancestry individuals
Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale)
3,820 Finnish ancestry individuals
Prevalent type 2 diabetes
911 Korean ancestry prevalent diabetes cases, 7,024 Korean ancestry incident diabetes and non-diabetes controls
1,895 Korean ancestry cases, 6,040 Korean ancestry controls
Residual cognition
Affymetrix, Illumina [~ 7000000] (imputed)
Nevirapine-induced hypersensitivity in HIV (drug-induced liver injury)
21 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls
16 Sub-Saharan African ancestry cases, 27 African ancestry cases, 60 Sub-Saharan African ancestry controls, 8 African ancestry controls
Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis)
51 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls
11 Sub-Saharan African ancestry cases, 27 African ancestry cases, 60 Sub-Saharan African ancestry controls, 8 African ancestry controls
Nevirapine-induced hypersensitivity in HIV (hypersensitivity syndrome)
23 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls
Nevirapine-induced hypersensitivity in HIV (rash)
56 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls
27 Sub-Saharan African ancestry cases, 60 Sub-Saharan African ancestry controls
Nevirapine-induced hypersensitivity in HIV
151 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls
62 Sub-Saharan African ancestry cases, 60 Sub-Saharan African ancestry controls
67 Greater Middle Eastern ancestry cases, 214 Greater Middle Eastern ancestry controls
1,952 European ancestry cases, 2,960 European ancestry controls
700 Japanese ancestry cases, 1,797 Japanese ancestry controls, 564 European ancestry cases, 1,776 European ancestry controls
564 Japanese ancestry cases, 1,863 Japanese ancestry controls, 2,592 European ancestry cases, 9,315 European ancestry controls
Seborrheic dermatitis
609 European and unknown ancestry cases, 3441 European and unknown ancestry controls
Waist-to-hip ratio adjusted for BMI (smoking interaction)
Body mass index (joint analysis main effects and smoking interaction)
Waist circumference adjusted for BMI in non-smokers
77,113 European ancestry women, 47,319 European ancestry men, 4,856 European ancestry individuals, 8,799 African American/Afro-Caribbean ancestry women, 1,803 African American/Afro-Caribbean ancestry men, 1,020 Indian Asian ancestry women, 6,691 Indian Asian ancestry men, 1,526 Filipino ancestry women, 2,469 Hispanic/Latino ancestry women, 1,318 Hispanic/Latino ancestry men
BMI in non-smokers
77,279 European ancestry women, 47,280 European ancestry men, 4,856 European ancestry individuals, 8,799 African American/Afro-Caribbean ancestry women, 1,803 African American/Afro-Caribbean ancestry men, 1,020 Indian Asian ancestry women, 6,691 Indian Asian ancestry men, 1,526 Filipino ancestry women, 2,469 Hispanic/Latino ancestry women, 1,318 Hispanic/Latino ancestry men
Waist circumference adjusted for BMI in smokers
19,276 European ancestry women, 16,408 European ancestry men, 973 European ancestry individuals, 1,701 African American/Afro-Caribbean ancestry women, 903 African American/Afro-Caribbean ancestry men, 10 Indian Asian ancestry women, 957 Indian Asian ancestry men, 267 Filipino ancestry women, 475 Hispanic/Latino ancestry women, 446 Hispanic/Latino ancestry men
BMI in smokers
19,883 European ancestry women, up to 16,928 European ancestry men, up to 973 European ancestry individuals, 1,701 African American/Afro-Caribbean ancestry women, 903 African American/Afro-Caribbean ancestry men, 10 Indian Asian ancestry women, 957 Indian Asian ancestry men, 267 Filipino ancestry women, 475 Hispanic/Latino ancestry women, 446 Hispanic/Latino ancestry men
1,726 European ancestry cases, 5,482 European ancestry controls
1,912 European ancestry cases, 5,938 European ancestry controls, 781 African American cases, 876 African American controls
Chickenpox
107,769 European ancestry cases, 15,982 European ancestry controls
16,711 European ancestry cases, 118,152 European ancestry controls
Cold sores
25,108 European ancestry cases, 63,332 European ancestry controls
Mumps
31,227 European ancestry cases, 54,153 European ancestry controls
Plantar warts
24,994 European ancestry cases, 37,451 European ancestry controls
4,426 European ancestry cases, 84,290 European ancestry controls
Bacterial meningitis
842 European ancestry cases, 82,778 European ancestry controls
Yeast infection
52,218 European ancestry cases, 10,235 European ancestry controls
Myringotomy
4,138 European ancestry cases, 85,089 European ancestry controls
Measles
38,219 European ancestry cases, 47,279 European ancestry controls
Hepatitis A
2,442 European ancestry cases, 217,137 European ancestry controls
Rheumatic fever
1,115 European ancestry cases, 88,076 European ancestry controls
Number of common colds
43,826 European ancestry cases, 15,720 European ancestry controls
Chronic sinus infection
5,291 European ancestry cases, 79,622 European ancestry controls
Urinary tract infection frequency
35,000 European ancestry cases, 33,478 European ancestry controls
Rubella
12,000 European ancestry cases, 71,597 European ancestry controls
Mononucleosis
17,457 European ancestry cases, 68,446 European ancestry controls
1,425 European ancestry cases, 218,180 European ancestry controls
Strep throat
52,487 European ancestry cases, 22,017 European ancestry controls
Scarlet fever
6,812 European ancestry cases, 113,837 European ancestry controls
Pneumonia
40,600 European ancestry cases, 90,039 European ancestry controls
Survival in pancreatic cancer
868 European ancestry cases
820 European ancestry cases
up to 13,031 African American individuals, 40,407 European ancestry individuals
Affymetrix, Illumina [2955816] (imputed)
2,273 Sardinian cases, 2,148 Sardinian controls
6,840 European ancestry cases, 661 Sardinian cases, 3,176 cases, 6,044 European ancestry controls, 1,244 Sardinian controls, 2,958 controls
Alcoholic chronic pancreatitis
1,959 European ancestry cases, 1,488 European ancestry alcohol abuse controls, 4,552 European ancestry controls
27,488 European ancestry individuals, 842 Old Order Amish individuals
42,360 European ancestry individuals, 380 African American individuals, 2,350 Korean ancestry individuals
Affymetrix, Illumina [at least 1912063] (imputed)
37,450 European ancestry individuals, 842 Old Order Amish individuals
47,227 European ancestry individuals, 380 African American individuals, 8,034 Korean ancestry individuals, 7,834 Indian ancestry individuals
Modified Stumvoll Insulin Sensitivity Index (BMI interaction)
16,753 European ancestry individuals
13,354 European ancestry individuals
Modified Stumvoll Insulin Sensitivity Index
Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI)
76,192 European ancestry cases, 63,082 European ancestry controls
46,785 European ancestry cases, 42,892 European ancestry controls, 14,068 East Asian ancestry cases, 13,104 East Asian ancestry controls
927 Saudi Arabian ancestry cases, 3,159 Saudi Arabian ancestry controls
317 Saudi Arabian ancestry cases, 1,098 Saudi Arabian ancestry controls
150,134 European ancestry individuals
87,359 European ancestry individuals, 140,886 European and unknown ancestry individuals
Affymetrix, Illumina, Perlegen [7994604] (imputed)
Benign prostatic hyperplasia and/or lower urinary tract symptoms
1,419 European ancestry cases, 498 cases, 1,684 European ancestry controls, 518 controls
485 Finnish ancestry cases, 475 Finnish ancestry controls
Lumbar spine bone mineral density or breast cancer (pleiotropy)
53,236 individuals with bone mineral density data, 5,152 Chinese ancestry breast cancer cases and controls
Femoral neck bone mineral density or breast cancer (pleiotropy)
Change in LVEF in response to paclitaxel in HER2+ breast cancer
391 European ancestry cases
Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer
800 European ancestry cases
Change in LVEF in response to paclitaxel and in response to paclitaxel and trastuzumab in HER+ breast cancer
1,191 European ancestry cases
1,960 European ancestry individuals
1,942 European ancestry cases, 4,565 European ancestry controls
Myeloid white cell count
169,219 European ancestry individuals
171,643 European ancestry individuals
Immature fraction of reticulocytes
170,548 European ancestry individuals
170,702 European ancestry individuals
172,332 European ancestry individuals
Basophil percentage of white cells
171,996 European ancestry individuals
Lymphocyte percentage of white cells
171,748 European ancestry individuals
Neutrophil percentage of white cells
171,542 European ancestry individuals
Basophil percentage of granulocytes
170,223 European ancestry individuals
164,454 European ancestry individuals
172,952 European ancestry individuals
3,789 European ancestry cases, 25,079 European ancestry controls
Primary sclerosing cholangitis associated immune-mediated diseases (Crohn's disease, celiac disease, psoriasis, rheumatoid arthritis, sarcoidosis, type 1 diabetes or ulcerative colitis) (pleiotropy)
6,333 European ancestry Crohn's disease cases, 4,533 European ancestry celiac disease cases, 2,529 European ancestry psoriasis cases, 5,539 European ancestry rheumatoid arthritis cases, 568 European ancestry sarcoidosis cases, 7,514 European ancestry type I diabetes cases, 6,687 European ancestry ulcerative colitis cases, 3,789 European ancestry sclerosing cholangitis cases, 106,357 European ancestry controls
5,414 European ancestry women, 4,308 European ancestry men
9,888 European ancestry individuals, 16,013 individuals
5,288 European ancestry women, 4,148 European ancestry men
5,458 European ancestry women, 4,273 European ancestry men
up to 9,888 European ancestry individuals, up to 16,013 individuals
5,501 European ancestry women, 4,323 European ancestry men
5,451 European ancestry women, 4,282 European ancestry men
5,468 European ancestry women, 4,294 European ancestry men
5,321 European ancestry women, 4,142 European ancestry men
5,495 European ancestry women, 4,322 European ancestry men
5,497 European ancestry women, 4,306 European ancestry men
5,467 European ancestry women, 4,280 European ancestry men
5,482 European ancestry women, 4,314 European ancestry men
5,392 European ancestry women, 4,275 European ancestry men
5,350 European ancestry women, 4,191 European ancestry men
Insulin-like growth factor 1 levels
5,455 European ancestry women, 4,277 European ancestry men
5,499 European ancestry women, 4,319 European ancestry men
4,259 European ancestry men
5,482 European ancestry women, 4,263 European ancestry men
5,498 European ancestry women, 4,320 European ancestry men
up to 5,574 European ancestry women, up to 4,387 European ancestry men
Chronic periodontitis (mean interproximal clinical attachment level)
10,935 Hispanic individuals
4,402 European ancestry individuals, 908 African American individuals
6,167 European ancestry cases, 17,159 European ancestry controls
4,112 European ancestry cases, 17,159 European ancestry controls
Barrett's esophagus or Esophageal adenocarcinoma
6,167 European ancestry Barrett's oesophagus cases, 4,112 European ancestry esophageal adenocarcinoma cases, 17,159 European ancestry controls
672 Korean ancestry cases, 3,700 Korean ancestry controls
200 Korean ancestry cases, 1,812 Korean ancestry controls
Severe gingival inflammation
4,077 European American individuals
94 Han Chinese ancestry very early onset cases, 91 Han Chinese ancestry very late onset cases
10,588 European ancestry cases, 22,806 European ancestry controls
Bone ultrasound measurement (velocity of sound)
1,268 whole genome sequenced European ancestry women, 8,880 European ancestry women, 6,479 European ancestry men
Bone ultrasound measurement (broadband ultrasound attenuation)
5,201 European ancestry cases, 9,066 European ancestry controls
2,018 European ancestry cases, 6,925 European ancestry controls
1,666 Puerto Rican child cases, 478 Puerto Rican adult cases, 1,505 Puerto Rican child controls, 1,388 Puerto Rican adult controls
Affymetrix, Illumina [7485508] (imputed)
Hepatocellular carcinoma in post hepatitis C eradication by interferon therapy
123 Japanese ancestry hepatocellular carcinoma cases, 333 Japanese ancestry 5-yr hepatocellular carcinoma-free controls
130 Japanese ancestry hepatocellular carcinoma cases, 210 Japanese ancestry 5-yr hepatocellular carcinoma-free controls
Neuropathy in taxane-treated breast cancer
151 African American cases, 576 European ancestry cases, 62 African American controls, 781 European ancestry controls
52 African American cases, 437 European ancestry cases, 38 African American controls, 352 European ancestry controls
1,583 Southern Chinese ancestry cases, 2,979 Southern Chinese ancestry controls
5,463 Southern Chinese ancestry cases, 5,591 Southern Chinese ancestry controls
767 European ancestry cases, 1,475 European ancestry controls
1,016 European ancestry cases, 1,060 European ancestry controls
Serum sulfate level
917 Old Order Amish (founder/genetic isolate) individuals
TB-LM or TBLH-BMD (pleiotropy)
8,327 European ancestry individuals, 2,087 individuals
6,579 European ancestry cases, 280,558 European ancestry controls
825 European ancestry cases, 11,518 European ancestry controls
HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes
781 European ancestry individuals, 138 African American ancestry individuals, 345 unknown ancestry individuals
Affymetrix, Illumina [8129838] (imputed)
LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes
Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes
Breast cancer, ovarian cancer or prostate cancer (pleiotropy)
62,533 European ancestry breast cancer female cases, 60,976 European ancestry controls, 15,437 European ancestry invasive epithelial ovarian cancer female cases, 30,845 European ancestry controls, 34,379 European ancestry prostate cancer male cases, 33,164 European ancestry controls
Bronchial hyperresponsiveness in asthma
920 Dutch ancestry cases, 980 Dutch ancestry controls
2,589 European ancestry cases, 473 cases, 6,702 European ancestry controls, 1,892 controls
Familial hepatitis B virus-related hepatocellular carcinoma
139 East Asian ancestry cases, 139 East Asian ancestry controls
Childhood insulin resistance
98 cases, 100 controls
79 cases, 78 controls
Itch intensity from mosquito bite
84,724 European ancestry individuals
Itch intensity from mosquito bite adjusted by bite size
41,355 European ancestry men and 43,369 European ancestry women
Mosquito bite size
Perceived unattractiveness to mosquitoes
16,576 European ancestry individuals
69,057 European ancestry individuals without immune related conditions
Conotruncal heart defects (inherited effects)
483 European ancestry trios, 406 European ancestry cases, 2,976 European ancestry controls, 355 European and other ancestry trios, 187 non-European ancestry trios.
Left ventricular obstructive tract defect (inherited effect)
247 European ancestry trios, 70 non-European ancestry trios, 192 European and other ancestry trios
Conotruncal heart defects (maternal effects)
up to 838 European ancestry trios
Left ventricular obstructive tract defect (maternal effect)
up to 439 European ancestry trios
Congenital heart disease (inherited effect)
1,119 European ancestry trios, 406 European ancestry cases, 2,976 European ancestry controls, 415 non-European ancestry trios
Congenital heart disease (maternal effect)
1,119 European ancestry trios
23,553 European ancestry individuals, 23,536 Japanese individuals, 16,325 Hispanic individuals, 8,224 African American individuals
Affymetrix, Illumina [at least 6581000] (imputed)
Achilles tendinopathy
4,258 European ancestry cases, 413 Latin-American cases, 268 East Asian ancestry cases, 192 African American cases, 17 South East Asian ancestry cases, 79,006 European ancestry controls, 8,147 Latin-American controls, 7,250 East Asian ancestry controls, 2,969 African American controls, 459 South East Asian ancestry controls
Anterior cruciate ligament rupture
495 European ancestry cases, 54 Latin-American cases, 49 East Asian ancestry cases, 82,769 European ancestry controls, 8,506 Latin-American controls, 7,469 East Asian ancestry controls
626 European ancestry individuals
Bone fracture in osteoporosis
up to 10,305 African American women
Apolipoprotein A-IV levels
13,813 European ancestry individuals
Spontaneous dizygotic twinning
1,980 European ancestry mothers of spontaneous dizygotic twins, 12,953 European ancestry controls
3,597 Icelandic ancestry mothers of spontaneous dizygotic twins, 297,348 Icelandic ancestry controls
Affymetrix, Illumina, Perlegen [at least 7903594] (imputed)
up to 26,676 European ancestry cases, up to 132,532 European ancestry controls
14,545 European ancestry cases, 38,994 European ancestry controls
Affymetrix, Illumina [at least 11579618] (imputed)
up to 12,543 European ancestry cases, up to 66,458 European ancestry controls
6,683 European ancestry cases, 12,173 European ancestry controls, 2,601 European ancestry affected sibling pair families, 69 European ancestry trios
Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction)
242 European ancestry individuals
12,278 Hispanic individuals
2,764 Brazilian individuals, at least 22,000 African American individuals, at least 155,786 European ancestry individuals
Acute graft versus host disease in bone marrow transplantation (recipient effect)
291 European ancestry recipients with acute graft versus host disease, 288 European ancestry recipients without acute graft versus host disease
Acute graft versus host disease in bone marrow transplantation (donor effect)
315 European ancestry donors (recipients with acute graft versus host disease), 341 European ancestry donors (recipients without graft versus host disease)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy)
1,516 European ancestry intracranial aneurysm cases, 818 European ancestry abdominal aortic aneurysm cases, 760 European ancestry thoracic aortic aneurysm cases, 9,507 European ancestry controls
972 Chinese ancestry cases, 1,316 Gambian ancestry cases, 1,537 Chinese ancestry controls, 1,382 Gambian ancestry controls
972 Chinese ancestry cases, 1,537 Chinese ancestry controls
3,338 Chinese ancestry cases, 4,849 Chinese ancestry controls
QT interval (ambient particulate matter interaction)
14,889 European ancestry individuals, 5,707 African American individuals, 1,562 Hispanic individuals
Blood pressure (parental or offspring effect)
515 children, 406 mothers and 237 fathers
Sporadic neuroblastoma
2,101 European ancestry child cases, 4,202 European ancestry controls
365 African American child cases, 2,491 African American controls, 427 European ancestry cases, 783 European ancestry controls, 371 cases, 1,122 controls
Language performance in older adults (adjusted for episodic memory)
310 European ancestry Alzheimer's disease individuals, 511 European ancestry individuals with late mild cognitive impairment, 280 European ancestry individuals with early mild cognitive impairment, 94 European ancestry individuals with significant memory concern, 365 European ancestry individuals with normal cognition
Petaloid toenail
up to 2,961 Han Chinese ancestry individuals, up to 721 Uyghur ancestry individuals
Foot ulcer in diabetes and neuropathy
662 European ancestry type 2 diabetes cases, 37 European ancestry type 1 diabetes cases, 2,584 European ancestry type 2 diabetes controls, 111 European ancestry type 1 diabetes controls
Affymetrix, Illumina [6706850] (imputed)
Foot ulcer and neuropathy in diabetes
662 European ancestry type 2 diabetes and neuropathy cases, 37 European ancestry type 1 diabetes and neuropathy cases, 4,250 European ancestry type 1 and type 2 diabetes controls
2,332 European ancestry cases and 5,233 European ancestry controls
764 European ancestry cases and 2,256 European ancestry controls
Alloimmunization response to pregnancy (HLA class I and II)
up to 193 European ancestry alloantibody-positive previously pregnant cases, 753 European ancestry alloantibody-negative previously pregnant controls
Alloimmunization response to pregnancy (HLA class I)
up to 247 European ancestry alloantibody-positive previously pregnant cases, 753 European ancestry alloantibody-negative previously pregnant controls
Alloimmunization response to pregnancy (HLA class II)
up to 332 European ancestry alloantibody-positive previously pregnant cases, 753 European ancestry alloantibody-negative previously pregnant controls
Alloimmunization response to pregnancy
752 European ancestry alloantibody-positive previously pregnant cases, 753 European ancestry alloantibody-negative previously pregnant controls
3,331 European ancestry preterm birth mothers, 40,236 European ancestry term birth mothers
2,565 European ancestry preterm birth mothers, 6,034 European ancestry term birth mothers
43,568 European ancestry mothers
8,643 European ancestry mothers
Restricted and repetitive behaviours in autism spectrum disorder
4,664 European ancestry children from 2,145 families
DDT metabolite (p,p'-DDE levels)
up to 1,016 European ancestry individuals
Parental longevity (at least one long-lived parent)
1,140 European American individuals with at least one long-lived parent, 3,894 European American individuals, 137 African American individuals with at least one long-lived parent, 545 African American individuals
1,950 individuals
9,069 European ancestry cases, 1,550 East Asian ancestry cases, 13,578 European ancestry controls, 1,567 East Asian ancestry controls
Ankylosing spondylitis (SNP x SNP interaction)
9,069 European ancestry cases, 13,578 European ancestry controls
3962 African American cases, 711 African ancestry cases, 4,150 African ancestry controls, 624 African ancestry controls
1,984 African American cases, 2,939 African American controls
1795 African American cases, 99 African ancestry cases, 4,150 African American controls, 624 African ancestry controls
1093 African American cases, 2939 African American controls
1349 African American cases, 42 African ancestry cases, 4,150 African American controls, 624 African ancestry controls
573 African American cases, 2,939 African American controls
Coronary artery disease severity measurement
4,931 European ancestry individuals
Response to statins (HDL cholesterol change)
16,769 European ancestry individuals
10,951 European ancestry individuals
Affymetrix, Illumina, Perlegen [up to 2500000] (imputed)
Antisocial behavior
7,054 European ancestry men, 7,926 European ancestry women
Affymetrix, Illumina [7392849] (imputed)
7,926 European ancestry women
7,054 European ancestry men
Resistance to antipsychotic treatment in schizophrenia
31 European ancestry treatment-resistant cases, 53 European ancestry non-treatment-resistant controls
Resistance to antipsychotic treatment in schizophrenia (childhood trauma interaction)
Relapse in multiple sclerosis
268 cases
181 cases
Thiopurine-induced severe leukopenia in inflammatory bowel disease (conditioned on rs116855232)
72 Japanese ancestry cases, 1,148 Japanese ancestry controls
196 Japanese ancestry cases, 1,024 Japanese ancestry controls
Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232)
Thiopurine-induced severe leukopenia in inflammatory bowel disease
Thiopurine-induced acute severe leukopenia in inflammatory bowel disease
43 Japanese ancestry cases, 1,172 Japanese ancestry controls
Thiopurine-induced alopecia in inflammatory bowel disease
81 Japanese ancestry cases, 1,139 Japanese ancestry controls
Thiopurine-induced severe alopecia in inflammatory bowel disease
41 Japanese ancestry cases, 1,179 Japanese ancestry controls
Thiopurine-induced pancreatitis in inflammatory bowel disease
18 Japanese ancestry cases, 1,202 Japanese ancestry controls
Thiopurine-induced fever in inflammatory bowel disease
10 Japanese ancestry cases, 1,210 Japanese ancestry controls
Thiopurine-induced digestive symptoms in inflammatory bowel disease
93 Japanese ancestry cases, 1,127 Japanese ancestry controls
Thiopurine-induced infection in inflammatory bowel disease
14 Japanese ancestry cases, 1,206 Japanese ancestry controls
Thiopurine-induced liver dysfunction in inflammatory bowel disease
39 Japanese ancestry cases, 1,181 Japanese ancestry controls
Thiopurine-induced skin symptoms in inflammatory bowel disease
6 Japanese ancestry cases, 1,214 Japanese ancestry controls
Thiopurine-induced alopecia in inflammatory bowel disease (conditioned on rs116855232)
Thiopurine-induced acute severe leukopenia in inflammatory bowel disease (conditioned on rs116855232)
Thiopurine-induced severe alopecia in inflammatory bowel disease (conditioned on rs116855232)
324,851 European ancestry individuals, 21,962 South Asian ancestry individuals
up to 275,596 European ancestry individuals
Affymetrix, Illumina [up to 1207583] (imputed)
128,746 European and South Asian ancestry individuals
131,892 European and South Asian ancestry individuals
121,543 European and South Asian ancestry individuals
Urinary haptoglobin levels in type 2 diabetes
236 Chinese ancestry individuals
512 Chinese ancestry individuals, 57 Malay ancestry individuals
Plasma haptoglobin levels in type 2 diabetes
57 Malay ancestry individuals
367 European ancestry typical cases, 55 European ancestry atypical cases, 165 European ancestry controls
Targeted genotyping array [ImmunoChip, NeuroX]
1,715 Finnish ancestry ever smoker individuals from 739 families
7,344 Finnish ancestry ever smoker individuals
Smoking behaviour (maximum cigarettes in a 24 hour period)
1,711 Finnish ancestry ever smoker individuals from up to 739 families
873 Finnish ancestry cases and 842 Finnish ancestry controls from 739 families
Nicotine withdrawal symptom count
1,703 Finnish ancestry ever smoker individuals from up to 739 families
Nicotine withdrawal
540 Finnish ancestry cases and 1,163 Finnish ancestry controls from up to 739 families
1,381 Japanese ancestry cases, 1,505 Japanese ancestry controls
512 Japanese ancestry cases, 6,512 Japanese ancestry controls
Cerebrospinal fluid biomarker levels
133 Japanese ancestry individuals.
Liver disease severity in Alagille syndrome
97 European ancestry mild cases, 64 European ancestry severe cases
3,964 African American ancestry individuals.
16,169 European ancestry individuals
2,045 European ancestry individuals
Affymetrix, Illumina [7353638] (imputed)
Palmar length-width ratio in Kashin-Beck disease
90 Han Chinese ancestry individuals
403 Han Chinese ancestry individuals
29,925 British ancestry cases, 89,763 British ancestry controls
4,040 British ancestry cases, 113,735 British ancestry controls
Erosive tooth wear (severe vs non-severe)
86 Finnish ancestry male severe erosion cases, 50 Finnish ancestry female severe erosion cases, 817 Finnish ancestry male non-severe erosion controls, 991 Finnish ancestry female non-severe erosion controls
Erosive tooth wear (severe vs none or mild)
136 Finnish ancestry severe erosion cases, 1011 Finnish ancestry mild or no erosion controls
1,149 European and unknown ancestry cases, 4,836 European and unknown ancestry controls
Pneumococcal meningitis x streptococcus pneumoniae genotype cluster interaction
up to 145 European and unknown ancestry individuals
Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction
up to 347 European and unknown ancestry individuals
2,345 European and unknown ancestry cases, 345,042 European and unknown ancestry controls
Affymetrix, Illumina [6800000] (imputed)
Pneumococcal meningitis
732 European and unknown ancestry cases, 4,836 European and unknown ancestry controls
353 European ancestry cases, 3,278 European ancestry controls
Severe bacterial meningitis
277 European and unknown ancestry cases, 4,836 European and unknown ancestry controls
873 European ancestry cases, 3,278 European ancestry controls
Triacylglyceride levels
Ceramide levels
Diacylglyceride levels
Lysophosphatidylcholine levels
Lysophosphatidylethanolamine levels
Phosphatidylcholine levels
Phosphatidylcholine-ether levels
Phosphatidylethanolamine levels
Phosphatidylethanolamine-ether levels
Phosphatidylinositol levels
Cholesteryl ester levels
Sphingomyelin levels
Sterol levels
16,920 European ancestry individuals
1,742 European ancestry individuals, 1,083 African American individuals, 586 Chinese ancestry individuals, 972 Hispanic individuals
16,917 European ancestry individuals
16,923 European ancestry individuals
16,884 European ancestry individuals
Bicuspid aortic valve without aortic dilation
565 European ancestry cases, 484 European ancestry controls
895 European ancestry cases, 1,493 European ancestry controls
Adverse response to drug
16,226 European ancestry individuals
Handedness (non-right-handed vs right-handed)
44,631 European ancestry non-right-handed individuals, 356,567 European ancestry right-handed individuals
38,322 European ancestry left-handed individuals, 362,866 European ancestry right-handed individuals
Handedness (left-handed vs. right-handed)
38,322 European ancestry left-handed individuals, 356,567 European ancestry right-handed individuals
Nonsyndromic cleft lip
945 Southern Han Chinese ancestry cases, 5,048 Southern Han Chinese ancestry controls
1,273 Han Chinese ancestry cases, 5,097 Han Chinese ancestry controls
Nonsyndromic cleft palate
930 Southern Han Chinese ancestry cases, 5,048 Southern Han Chinese ancestry controls
1,141 Han Chinese ancestry cases, 5,097 Han Chinese ancestry controls
Differential aging in older adults (frontal cortex)
413 individuals
497 individuals
Differential aging in younger adults (frontal cortex)
303 individuals
Differential aging (cerebellum)
716 individuals
Differential aging in older adults (cerebellum)
Differential aging (frontal cortex)
5,421 European ancestry children
Systemising
51,564 European ancestry individuals
26,063 European ancestry men
25,501 European ancestry women
Psychotic experience
6,123 European ancestry cases, 121,379 European ancestry controls
Psychotic experience (multiple occurrences)
3,337 European ancestry cases, 121,379 European ancestry controls
Psychotic experience (distressing)
2,143 European ancestry cases, 121,379 European ancestry controls
Subscapular skin fold thickness
8,998 European and unknown ancestry Barrett's esophagus cases, 4,680 European and unknown ancestry esophageal adenocarcinoma cases, 19,247 European and unknown ancestry controls
80,265 European and unknown ancestry cases, 305,011 European and unknown ancestry controls
Affymetrix, Illumina [up to 7600000] (imputed)
Depressive symptom (depressed mood) (binary trait)
32,263 European ancestry cases, 116,489 European ancestry controls
Depressive symptom (sleep problems) (binary trait)
72,302 European ancestry cases, 76,450 European ancestry controls
Depressive symptom (fatigue) (binary trait)
73,924 European ancestry cases, 74,828 European ancestry controls
Depressive symptom (appetite changes) (binary trait)
26,757 European ancestry cases, 121,995 European ancestry controls
Depressive symptom (low self-esteem) (binary trait)
28,206 European ancestry cases, 120,546 European ancestry controls
Depressive symptom (concentration problems) (binary trait)
26,229 European ancestry cases, 122,523 European ancestry controls
Depressive symptom (psychomotor changes) (binary trait)
7,914 European ancestry cases, 140,838 European ancestry controls
Depressive symptom (suicidal ideation) (binary trait)
6,064 European ancestry cases, 142,688 European ancestry controls
Depressive symptoms (binary sum-score)
148,752 European ancestry individuals
Depressive symptoms (sum-score)
Depressive symptom (sleep problems) (ordinal trait)
Depressive symptom (fatigue) (ordinal trait)
Depressive symptom (appetite changes) (ordinal trait)
Depressive symptom (low self-esteem) (ordinal trait)
Depressive symptom (concentration problems) (ordinal trait)
Depressive symptom (psychomotor changes) (ordinal trait)
Depressive symptom (suicidal ideation) (ordinal trait)
Depressive symptom (anhedonia) (ordinal trait)
Depressive symptom (depressed mood) (ordinal trait)
Depressive symptom (anhedonia) (binary trait)
27,288 European ancestry cases, 121,464 European ancestry controls
1,622 European ancestry attempters, 8,786 European ancestry nonattempters
Suicide attempts in major depressive disorder or bipolar disorder or schizophrenia
1,622 European ancestry attempters with major depressive disorder, 8,786 European ancestry nonattempters with major depressive disorder, 3,264 European ancestry attempters with bipolar disorder, 5,500 European ancestry nonattempters with bipolar disorder, 1,683 European ancestry attempters with schizophrenia, 2,946 European ancestry nonattempters with schizophrenia
3,264 European ancestry attempters, 5,500 European ancestry nonattempters
Suicide attempts in schizophrenia
1,683 European ancestry attempters, 2,946 European ancestry nonattempters
Suicide attempts in major depressive disorder or bipolar disorder
1,622 European ancestry attempters with major depressive disorder, 8,786 European ancestry nonattempters with major depressive disorder, 3,264 European ancestry attempters with bipolar disorder, 5,500 European ancestry nonattempters with bipolar disorder
7,092 European ancestry attempters with major depressive disorder or bipolar disorder, 51,761 European ancestry nonattempters with major depressive disorder or bipolar disorder
Suicide attempts in bipolar disorder or schizophrenia
3,264 European ancestry attempters with bipolar disorder, 5,500 European ancestry nonattempters with bipolar disorder, 1,683 European ancestry attempters with schizophrenia, 2,946 European ancestry nonattempters with schizophrenia
17-hydroxyprogesterone (17-OHP) levels
1,358 European ancestry men, 712 European ancestry women
Androstenedione levels
Aldosterone levels
1,307 European ancestry men, 686 European ancestry women
4,191 European ancestry men, 2,607 European ancestry women
4,301 European ancestry men, 3,366 European ancestry women
DHEAS levels
4,301 European ancestry men, 3,358 European ancestry women
4,291 European ancestry men, 3,352 European ancestry women
Progesterone levels
1,358 European ancestry men, 1,261 European ancestry women
Smoking behaviour (age at first cigarette)
up to 2,705 African ancestry individuals
up to 2,685 African ancestry individuals
up to 7,594 African ancestry individuals
up to 2,658 African ancestry individuals
up to 8,974 African ancestry individuals
up to 146,117 European ancestry control
up to 153,918 European ancestry individuals
up to 150,993 European ancestry individuals
up to 433,216 European ancestry individuals
up to 357,854 European ancestry individuals
Perceived sweetness of sucrose
686 European ancestry twins
Sucrose liking
Intake of sweets
21,447 European ancestry individuals
Perceived intensity of fructose
1,757 European ancestry twins
Perceived intensity of neohesperidin dihydrochalcone
Perceived intensity of aspartame
Perceived intensity of sweet substances
Perceived intensity of sucrose
2,443 European ancestry twins
Intake of total sugars
174,424 European ancestry individuals
Perceived intensity of glucose
Subjective response to placebo treatment in childhood asthma (change in cough/wheeze)
250 European ancestry children
Response to placebo treatment in childhood asthma (FVC change)
Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia
190 European ancestry cases
Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia
190 European ancestry Alzheimer's disease dementia cases
Hippocampal volume in Alzheimer's disease dementia
Logical memory (immediate recall) in Alzheimer's disease dementia
Logical memory (delayed recall) in Alzheimer's disease dementia
Cerebrospinal AB1-42 levels in mild cognitive impairment
581 European ancestry MCI dementia cases
Cerebrospinal fluid t-tau levels in mild cognitive impairment
Cerebrospinal fluid p-tau levels in mild cognitive impairment
581 European ancestry mild cognitive impairment cases
Hippocampal volume in mild cognitive impairment
Logical memory (immediate recall) in mild cognitive impairment
Logical memory (delayed recall) in mild cognitive impairment
Cerebrospinal AB1-42 levels in normal cognition
305 European ancestry cognitively normal individuals
Cerebrospinal fluid t-tau levels in normal cognition
Cerebrospinal fluid p-tau levels in normal cognition
Hippocampal volume in normal cognition
Logical memory (immediate recall) in normal cognition
Logical memory (delayed recall) in normal cognition
305 European ancestry cognitively normal individuals, 581 European ancestry mild cognitive impairment cases, 190 European ancestry Alzheimer's disease dementia cases
Logical memory (immediate recall)
Logical memory (delayed recall)
190 European ancestry AD dementia cases
Superior frontal gyrus volume
87 European ancestry Schizophrenia cases, 85 African American Schizophrenia cases, 15 Schizophrenia cases, 67 European ancestry Schizoaffective disorder cases, 53 African American Schizoaffective disorder cases, 7 Schizoaffective disorder cases, 130 European ancestry Bipolar disorders cases, 33 African American Bipolar disorders cases, 6 Bipolar disorders cases, 199 European ancestry controls, 79 African American controls, 16 controls
Superior parietal cortex volume
Superior temporal gyrus volume
Supramarginal gyrus volume
Frontal pole volume
Temporal pole volume
Transverse temporal cortex volume
Insular cortex volume
Ventral diencephalon volume
Choroid plexus volume
Lateral ventricle volume
Lateral ventricle temporal horn volume
Third ventricle volume
Fourth ventricle volume
Corpus callosum posterior volume
Corpus callosum Mid-posterior volume
Corpus callosum central volume
Corpus callosum mid-anterior volume
Caudal anterior-cingulate cortex volume
Caudal middle frontal gyrus volume
Cuneus cortex volume
Fusiform gyrus volume
Inferior parietal cortex volume
Inferior temporal gyrus volume
Isthmus-cingulate cortex volume
Lateral occipital cortex volume
Lateral orbital frontal cortex volume
Lingual gyrus volume
Medial orbital frontal cortex volume
Middle temporal gyrus volume
Parahippocampal gyrus volume
Paracentral lobule volume
Pars opercularis volume
Pars orbitalis volume
Pars triangularis volume
Pericalcarine cortex volume
Postcentral gyrus volume
Posterior-cingulate cortex volume
Precentral gyrus volume
Precuneus cortex volume
Rostral anterior cingulate cortex volume
Rostral middle frontal gyrus volume
1,079 European ancestry cases, 128 European ancestry controls, 1,303 African American cases, 791 African American controls
637 European ancestry cases, 41 European ancestry controls
Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils)
132 European ancestry severe cases, 288 European ancestry mild cases
Hearing loss in Charcot-Marie-Tooth disease 1A
61 European ancestry severe cases, 303 European ancestry mild cases
Decreased sensory function in Charcot-Marie-Tooth disease type 1A
308 European ancestry severe cases, 112 European ancestry mild cases
Neuropathy in Charcot-Marie-Tooth disease type 1A
471 European ancestry individuals
Balance difficulty in Charcot-Marie-Tooth disease type 1A
352 European ancestry severe cases, 61 European ancestry mild cases
Decreased fine motor function in Charcot-Marie-Tooth disease 1A (buttons, zippers, fasteners, bottles)
277 European ancestry severe cases, 146 European ancestry mild cases
Walking difficulty in Charcot-Marie-Tooth disease 1A
362 European ancestry severe cases, 62 European ancestry mild cases
174 European ancestry severe cases, 117 European ancestry mild cases
First dorsal interosseous strength in Charcot-Marie-Tooth disease 1A
120 European ancestry severe cases, 80 European ancestry mild cases
Foot deformity in Charcot-Marie-Tooth disease 1A
368 European ancestry severe cases, 49 European ancestry mild cases
Foot plantar flexion strength in Charcot-Marie-Tooth disease 1A
136 European ancestry severe cases, 276 European ancestry mild cases
Scoliosis in Charcot-Marie-Tooth disease 1A
91 European ancestry severe cases, 318 European ancestry mild cases
Arthritic-like pain in Charcot-Marie-Tooth type 1A
197 European ancestry severe cases, 212 European ancestry mild cases
Burning or tingling in extremities in Charcot-Marie-Tooth disease type 1A
141 European ancestry severe cases, 265 European ancestry mild cases
Response to interferon treatment in hepatitis C virus genotype 3
717 European, Asian and unknown ancestry responders, 541 European, Asian and unknown ancestry non-responders
Response to direct-acting antiviral treatment in hepatitis C virus genotype 3
325 European, Asian and unknown ancestry responders, 84 European, Asian and unknown ancestry non-responders
Pre-treatment viral load in hepatitis C virus genotype 3
1,498 European, Asian and unknown ancestry individuals
103 Han Chinese ancestry cases, 115 Han Chinese ancestry controls
567,460 European ancestry individuals, 165,726 East Asian ancestry individuals, 13,842 African American individuals, 13,359 South Asian ancestry individuals, 4,961 Hispanic individuals
216,518 European ancestry individuals, 64,204 non-Hispanic black individuals
Affymetrix, Illumina [8221591] (imputed)
567,460 European ancestry individuals
216,518 European ancestry individuals
Affymetrix, Illumina [8834748] (imputed)
165,726 East Asian ancestry individuals
13,359 South Asian ancestry individuals
416,178 European and unknown ancestry individuals
Affymetrix, Illumina [8176554] (imputed)
243,029 European ancestry individuals
Affymetrix, Illumina [8358347] (imputed)
64,164 European and unknown ancestry cases, 561,055 European and unknown ancestry controls
Affymetrix, Illumina [9585923] (imputed)
up to 64,164 European ancestry cases, up to 561,055 European ancestry controls
13,842 African American individuals
Non-muscle-invasive bladder cancer age at diagnosis
653 European ancestry cases
1470 European ancestry cases
Non-muscle-invasive bladder cancer age at diagnosis (< 70 years vs ≥ 70 years)
298 European ancestry cases under 70 years, 355 European ancestry cases 70 years or older
329 European ancestry cases under 70 years, 1,141 European ancestry cases 70 years or older
Non-muscle-invasive bladder cancer tumour size
633 European ancestry cases
302 European ancestry cases
Non-muscle-invasive bladder cancer tumour size (< 3 cm vs ≥ 3 cm)
Non-muscle-invasive bladder cancer tumour stage (Tis/T1 vs Ta)
209 European ancestry stage Tis/T1 cases, 444 European ancestry stage Ta cases
414 European ancestry stage Tis/T1 cases, 1,056 European ancestry stage Ta cases
Non-muscle-invasive bladder cancer tumour grade (G3 vs G2/G1)
207 European ancestry grade G3 cases, 436 European ancestry grade G2/G1 cases
304 European ancestry grade G3 cases, 1,019 European ancestry grade G2/G1 cases
Non-muscle-invasive bladder cancer EORTC risk category
311 European ancestry high risk cases, 342 European ancestry low/intermediate risk cases
4,650 East Asian ancestry individuals
4,206 East Asian ancestry individuals
Plasma factor V levels in venous thrombosis
510 European ancestry individuals
1,156 European ancestry individuals
Plasma factor V levels in venous thrombosis (conditioned on rs6027)
813 individuals
580 individuals
Number of alcoholic drinks required to feel an effect (first five times drinking)
4,723 European ancestry individuals from 956 families, 1,527 African American individuals from 309 families
306 European ancestry individuals, 169 African American individuals
Number of alcoholic drinks required to feel an effect (long-term average)
Stress sensitivity (neuroticism score x major depressive disorder status interaction)
2,010 European ancestry cases, 5,145 European ancestry controls
7,834 European ancestry cases, 15,258 European ancestry controls
9,844 European ancestry cases, 20,403 European ancestry controls
30,247 European ancestry individuals
5,327 Japanese ancestry cases, 73,884 Japanese ancestry controls
5,004 Japanese ancestry female cases, 33,679 Japanese ancestry female controls
Type 2 diabetes or obesity or coronary artery disease (pleiotropy)
234,069 European ancestry individuals, 48,286 European ancestry type 2 diabetes cases, 250,671 European ancestry type 2 diabetes controls, 22,233 European ancestry coronary artery disease cases, 64,762 European ancestry coronary artery disease controls
1,249 European ancestry male cases, 2,789 European ancestry male controls, 1,525 European ancestry female cases, 4,307 European ancestry female controls
Obsessive-compulsive disorder x sex interaction
2,774 European ancestry cases, 7,096 European ancestry controls
778 individuals
HDL cholesterol and triglyceride levels
Verbal intelligence quotient (cesarean section interaction)
519 European ancestry child cases, 1,902 European ancestry child controls
Performance intelligence quotient (cesarean section interaction)
Full scale intelligence quotient (cesarean section interaction)
Platelet count and reactivity phenotypes
534 European ancestry individuals
411 Japanese ancestry cases, 2,158 Japanese ancestry controls
219 Japanese ancestry cases, 3,770 Japanese ancestry controls
2,609 East Asian ancestry cases, 4,712 East Asian ancestry controls
1,461 Han Chinese ancestry cases, 3,295 Han Chinese ancestry controls
Affymetrix, Illumina [4602429] (imputed)
137 Japanese ancestry cases, 1,174 Japanese ancestry controls
183 Japanese ancestry cases, 2,071 Japanese ancestry controls
72 Chinese ancestry cases, 501 Chinese ancestry controls
32 Chinese ancestry cases, 604 Chinese ancestry controls
Pemphigus
350 Chinese ancestry cases, 501 Chinese ancestry controls
146 Chinese ancestry cases, 604 Chinese ancestry controls
255 Chinese ancestry cases, 501 Chinese ancestry controls
110 Chinese ancestry cases, 604 Chinese ancestry controls
2 Alaskan native ancestry schizophrenia cases, 18 Asian ancestry schizophrenia cases, 20 African American schizophrenia cases, 1 Native Hawaiian ancestry schizophrenia cases, 86 European ancestry schizophrenia cases, 2 Alaskan native ancestry controls, 10 Asian ancestry controls, 17 African American controls, 1 Native Hawaiian ancestry controls, 106 European ancestry controls
Working memory
Verbal memory
Visual memory
Reasoning
19,706 Hispanic individuals, 18,744 African American individuals
1,231 African American individuals
1,297 European American individuals
181 European American individuals
80,134 European ancestry cases, 364,890 European ancestry controls
Social isolation
2,426 European ancestry cases, 286,524 European ancestry controls
Ability to confide in someone
64,505 European ancestry cases, 238,062 European ancestry controls
Regular attendance at a gym or sports club
135,060 European ancestry cases, 317,242 European ancestry controls
Regular attendance at a pub or social club
124,047 European ancestry cases, 328,255 European ancestry controls
Regular attendance at a religious group
66,259 European ancestry cases, 386,043 European ancestry controls
Loneliness (MTAG)
487,647 European ancestry individuals
816 Indian ancestry cases, 900 Indian ancestry controls, 505 Indian ancestry cases and 871 Indian ancestry controls from 405 families, up to 36,989 European and unknown ancestry cases, up to 113,075 European and unknown ancestry controls
422 European ancestry cases, 5,642 European ancestry controls
Platelet reactivity measurement (collagen-ADP)
935 Spanish ancestry individuals
Platelet reactivity measurement (collagen-epinephrine)
Chronic lymphocytic leukemia or multiple sclerosis
2,492 European ancestry chronic lymphocytic leukemia cases, 9,772 European ancestry multiple sclerosis cases, 24,529 European ancestry controls
Diffuse large B-cell lymphoma or multiple sclerosis
3,617 European ancestry diffuse large B-cell lymphoma cases, 9,772 European ancestry multiple sclerosis cases, 24,813 European ancestry controls
Follicular lymphoma or multiple sclerosis
2,686 European ancestry follicular lymphoma cases, 9,772 European ancestry multiple sclerosis cases, 25,256 European ancestry controls
Marginal zone lymphoma or multiple sclerosis
741 European ancestry marginal zone lymphoma cases, 9,772 European ancestry multiple sclerosis cases, 23,367 European ancestry controls
Chronic lymphocytic leukemia or rheumatoid arthritis
2,492 European ancestry chronic lymphocytic leukemia cases, 3,921 European ancestry rheumatoid arthritis cases, 11,232 European ancestry controls
Diffuse large B-cell lymphoma or rheumatoid arthritis
3,617 European ancestry diffuse large B-cell lymphoma cases, 3,921 European ancestry rheumatoid arthritis cases, 11,516 European ancestry controls
Follicular lymphoma or rheumatoid arthritis
2,686 European ancestry follicular lymphoma cases, 3,921 European ancestry rheumatoid arthritis cases, 11,959 European ancestry controls
Marginal zone lymphoma or rheumatoid arthritis
741 European ancestry marginal zone lymphoma cases, 3,921 European ancestry rheumatoid arthritis cases, 10,070 European ancestry controls
Chronic lymphocytic leukemia or systemic lupus erythematosus
2,492 European ancestry chronic lymphocytic leukemia cases, 7,219 European ancestry systemic lupus erythematosus cases, 23,144 European ancestry controls
Diffuse large B-cell lymphoma or systemic lupus erythematosus
3,617 European ancestry diffuse large B-cell lymphoma cases, 7,219 European ancestry systemic lupus erythematosus cases, 23,428 European ancestry controls
Follicular lymphoma or systemic lupus erythematosus
2,686 European ancestry follicular lymphoma cases, 7,219 European ancestry systemic lupus erythematosus cases, 23,871 European ancestry controls
Marginal zone lymphoma or systemic lupus erythematosus
741 European ancestry marginal zone lymphoma cases, 7,219 European ancestry systemic lupus erythematosus cases, 21,982 European ancestry controls
Estimated glomerular filtration rate reduction (30%)
up to 3,617 Korean ancestry individuals
Incident chronic kidney disease
281 Korean ancestry cases, 3,336 Korean ancestry controls
Trastuzumab-induced cardiotoxicity in cancer
11 Japanese ancestry cases, 257 Japanese ancestry controls
14 Japanese ancestry cases, 199 Japanese ancestry controls
533 Han Chinese ancestry cases, 2,848 Han Chinese ancestry controls
146 Han Chinese ancestry cases, 200 Han Chinese ancestry controls
Parental longevity (father's age at death or father's attained age)
up to 699,000 European ancestry individuals
Parental longevity (mother's age at death or mother's attained age)
up to 699,000 individuals
270,548 European ancestry individuals
309,383 European ancestry individuals
up to 482,000 European ancestry individuals
722 Korean ancestry cases, 461 Korean ancestry controls
948 Korean ancestry cases, 977 Korean ancestry controls
Abstraction and mental flexibility
523 European ancestry schizophrenia cases, 100 Latino schizophrenia cases, 827 European ancestry controls, 83 Latino controls
Face memory
Sensorimotor dexterity
Spatial memory
Spatial processing
California verbal learning test score
Degraded stimulus continuous performance test score
Letter-number span reordering
Prepulse inhibition of the startle response
Antisaccade task score
FEV1 decline rate x corticosteroid treatment interaction in chronic obstructive pulmonary disease
401 European ancestry drug-treated cases, 401 European ancestry placebo-treated cases
163 drug-treated cases, 36 placebo-treated cases
4,948 European ancestry cases, 12,076 European ancestry controls
Macroalbuminuria in type 1 diabetes
2,751 European ancestry cases, 12,124 European ancestry controls
2,187 European ancestry cases, 12,101 European ancestry controls
2,187 European ancestry cases, 17,219 European ancestry controls
Kidney disease (end stage renal disease vs macroalbuminuria) in type 1 diabetes
2,187 European ancestry cases, 2,725 European ancestry controls
Microalbuminuria in type 1 diabetes
2,447 European ancestry cases, 12,113 European ancestry controls
Chronic kidney disease (reduced eGFR or end stage renal disease) in type 1 diabetes
4,266 European ancestry cases, 14,838 European ancestry controls
Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes
2,235 European ancestry cases, 14,993 European ancestry controls
Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes
2,987 European ancestry cases, 11,766 European ancestry controls
Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes
7,247 European ancestry cases, 12,053 European ancestry controls
Recurrence of malaria infection (mild or asymptomatic)
525 Beninese individuals
250 Beninese individuals
Recurrence of mild malaria attacks
858 Metropolitan French ancestry individuals
Gut microbiota (alpha diversity)
Gut microbiota relative abundance (bacterial taxa)
up to 858 Metropolitan French ancestry individuals
Urinary sodium excretion
446,237 European ancestry individuals
7,612 African ancestry individuals, 10,095 South Asian ancestry individuals
Urinary potassium excretion
446,230 European ancestry individuals
Asthma (time to onset)
5,462 European ancestry cases, 8,424 European ancestry controls
Chronic mountain sickness
166 Quechua cases, 146 Quechua controls
4,611 European ancestry adolescents
Non-lobar intracerebral hemorrhage
1,005 European ancestry cases, 1,711 European ancestry controls
Affymetrix, Illumina [39235000] (imputed)
Lobar intracerebral hemorrhage
755 European ancestry cases, 1,711 European ancestry controls
Intracerebral hemorrhage (MTAG)
at least 1,808 European ancestry cases, at least 1,711 European ancestry controls
Non-lobar intracerebral hemorrhage (MTAG)
at least 1,005 European ancestry cases, at least 1,711 European ancestry controls
Lobar intracerebral hemorrhage (MTAG)
at least 755 European ancestry cases, at least 1,711 European ancestry controls
1,808 European ancestry cases, 1,711 European ancestry controls
38,199 European ancestry adults
54,550 European ancestry adults, 5,062 children
Affymetrix, Illumina [8694268] (imputed)
Retinal arteriolar tortuosity
3,094 European ancestry individuals
1,413 European ancestry individuals
Maximum retinal arteriolar tortuosity
Retinal venular tortuosity
Maximum retinal venular tortuosity
Retinal arteriole-to-venule ratio
Optic disc radius
Immunogenicity to anti-TNF therapy in Crohn's disease
1,240 European ancestry individuals
107 European ancestry individuals
Leukocyte count in ischemic stroke
2,064 Spanish ancestry individuals
407 European ancestry individuals
3,305 European ancestry cases, 36,151 European ancestry controls
Affymetrix, Illumina [up to 6976246] (imputed)
Longitudinal cocaine use
1,682 mostly never users, 296 moderate decrease users, 86 elevated chronic users, 167 mostly frequent users
291,107 European ancestry individuals
23,212 European ancestry cases, 4,363 African ancestry cases, 1,981 Latino and Native American ancestry cases, 151,447 European ancestry controls, 10,976 African ancestry controls, 3,722 Latino and Native American ancestry controls
Affymetrix, Illumina [~ 1175791] (imputed)
2,527 European ancestry individuals, 196 African ancestry individuals, 52 individuals
Affymetrix, Illumina [4802696] (imputed)
2,527 European ancestry individuals
Affymetrix, Illumina [2723488] (imputed)
up to 248,507 non-Hispanic white individuals, up to 68,155 non-Hispanic black individuals, up to 25,847 Hispanic individuals, up to 3,054 Asian ancestry individuals
660,648 European ancestry individuals
663,598 European ancestry individuals
Esotropia
224 European ancestry accommodative cases, 826 European ancestry non-accommodative cases, 3,740 European ancestry controls
66 European ancestry accommodative cases, 689 European ancestry non-accommodative cases, 1,712 European ancestry controls
Accommodative esotropia
224 European ancestry cases, 749 European ancestry controls
66 European ancestry cases, 264 European ancestry controls
Amblyopia
386 European ancestry cases, 1,700 European ancestry controls
45 European ancestry cases, 180 European ancestry controls
361 European ancestry cases, 1,700 European ancestry controls
172 European ancestry cases, 690 European ancestry controls
Non-accommodative esotropia
826 European ancestry cases, 2,991 European ancestry controls
689 European ancestry cases, 1,448 European ancestry controls
Age at suicide
719 Japanese ancestry individuals
746 Japanese ancestry cases, 14,049 Japanese ancestry controls
Skin aging measurement
1,534 Han Chinese ancestry women
964 European ancestry women
1,084 Han Chinese ancestry women (>50 years old)
924 Greek ancestry cases, 1,125 Greek ancestry controls
822 Greek ancestry cases, 1,125 Greek ancestry controls
Schizophrenia vs type 2 diabetes
924 Greek ancestry schizophrenia cases, 822 Greek ancestry T2D cases
Type 2 diabetes vs schizophrenia and type 2 diabetes
505 Greek ancestry schizophrenia and T2D cases, 822 Greek ancestry T2D cases
Schizophrenia and type 2 diabetes
505 Greek ancestry cases, 1,125 Greek ancestry controls
Schizophrenia vs schizophrenia and type 2 diabetes
505 Greek ancestry schizophrenia and T2D cases, 924 Greek ancestry schizophrenia cases
Benign prostatic hyperplasia and lower urinary tract symptoms
20,621 European ancestry cases, 280,541 European ancestry controls
Affymetrix, Illumina [42907111] (imputed)
Benign prostatic hyperplasia and lower urinary tract symptoms (prostate cancer excluded)
18,138 European ancestry cases, 277,213 European ancestry controls
11,708 European ancestry cases, 284,184 European ancestry controls
33,572 Icelandic ancestry individuals
Affymetrix, Illumina [up to 32463442] (imputed)
916 African American cases, 1,392 African American controls,
4,873 East Asian ancestry cases, 17,641 East Asian ancestry controls, 19,234 European ancestry cases, 61,654 European ancestry controls
Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test)
12,758 European ancestry heavy drinkers, 1,326 African American or Afro-Caribbean heavy drinkers, 648 Asian ancestry heavy drinkers, 364 Hispanic or Latin American heavy drinkers, 43,947 European ancestry light drinkers, 8,239 African American or Afro-Caribbean light drinkers, 1,141 Asian ancestry light drinkers, 4,448 Hispanic or Latin American light drinkers
42,079 European ancestry heavy drinkers, 217 African American or Afro-Caribbean heavy drinkers, 282,294 Asian ancestry heavy drinkers, 124 Hispanic ancestry heavy drinkers, 74,757 European ancestry light drinkers, 845 African American light drinkers, 24,129 Asian ancestry light drinkers, 411 Hispanic light drinkers
Affymetrix, Illumina [up to 39321347] (imputed)
Systolic blood pressure x alcohol consumption interaction (2df test)
63,608 European ancestry drinkers, 10,193 African American or Afro-Caribbean heavy drinkers, 2,441 Asian ancestry drinkers, 5,084 Hispanic or Latin American drinkers, 27,494 European ancestry non-drinkers, 11,224 African American or Afro-Caribbean non-drinkers, 9,924 Asian ancestry non-drinkers, 3,387 Hispanic or Latin American non-drinkers
238,002 European ancestry drinkers, 2,280 African American drinkers, 54,081 Asian ancestry drinkers, 6,452 Hispanic drinkers, 43,316 European ancestry non-drinkers, 2,761 African American non-drinkers, 86,945 Asian ancestry non-drinkers, 6,925 Hispanic non-drinkers
Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test)
42,078 European ancestry heavy drinkers, 217 African American heavy drinkers, 282,294 Asian ancestry heavy drinkers, 124 Hispanic heavy drinkers, 74,706 European ancestry light drinkers, 845 African American light drinkers, 24,129 Asian ancestry light drinkers, 411 Hispanic light drinkers
Pulse pressure x alcohol consumption interaction (2df test)
91,099 European ancestry drinkers and non-drinkers, 21,416 African American or Afro-Caribbean drinkers and non-drinkers, 12,365 Asian ancestry drinkers and non-drinkers, 8,470 Hispanic or Latin American drinkers and non-drinkers
238,053 European ancestry drinkers, 2,280 African American drinkers, 54,080 Asian ancestry drinkers, 6,447 Hispanic ancestry drinkers, 43,318 European ancestry non-drinkers, 2,761 African American non-drinkers, 86,943 Asian ancestry non-drinkers, 6,923 Hispanic ancestry non-drinkers
Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test)
56,705 European ancestry heavy and light drinkers, 9,725 African American or Afro-Caribbean heavy and light drinkers, 1,789 Asian ancestry heavy and light drinkers, 4,812 Hispanic or Latin American heavy and light drinkers
42,079 European ancestry heavy drinkers, 217 African American heavy drinkers, 282,294 Asian ancestry heavy drinkers, 124 Hispanic heavy drinkers, 74,756 European ancestry light drinkers, 845 African American light drinkers, 24,129 Asian ancestry light drinkers, 411 Hispanic light drinkers
Mean arterial pressure x alcohol consumption interaction (2df test)
91,110 European ancestry drinkers and non-drinkers, 21,416 African American or Afro-Caribbean drinkers and non-drinkers, 12,365 Asian ancestry drinkers and non-drinkers, 8,470 Hispanic or Latin American drinkers and non-drinkers
237,996 European ancestry drinkers, 2,280 African American drinkers, 54,080 Asian ancestry drinkers, 6,448 Hispanic drinkers, 43,315 European ancestry non-drinkers, 2,761 African ancestry non-drinkers, 86,943 Asian ancestry non-drinkers, 6,923 Hispanic non-drinkers
Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test)
42,077 European ancestry heavy drinkers, 217 African American heavy drinkers, 282,294 Asian ancestry heavy drinkers, 124 Hispanic ancestry heavy drinkers, 74,701 European ancestry light drinkers, 845 African American light drinkers, 24,129 Asian ancestry light drinkers, 411 Hispanic light drinkers
Diastolic blood pressure x alcohol consumption interaction (2df test)
63,607 European ancestry drinkers, 10,193 African American or Afro-Caribbean drinkers, 2,441 Asian ancestry drinkers, 5,084 Hispanic or Latin American drinkers, 27,492 European ancestry non-drinkers, 11,223 African American or Afro-Caribbean non-drinkers, 9,924 Asian ancestry non-drinkers, 3,387 Hispanic or Latin American non-drinkers
238,058 European ancestry drinkers, 2,280 African American drinkers, 54,081 Asian ancestry drinkers, 6,448 Hispanic drinkers, 43,318 European ancestry non-drinkers, 2,761 African American non-drinkers, 86,943 Asian ancestry non-drinkers, 6,923 Hispanic non-drinkers
Lymphangioleiomyomatosis (sporadic)
426 European ancestry cases, 852 European ancestry controls
196 European ancestry cases, up to 226,140 European ancestry controls, up to 1,121 Hispanic white controls
Fasting glucose change
13,807 European ancestry individuals
Affymetrix, Illumina [~ 25000000] (imputed)
Fasting glucose change (long-term)
3,669 European ancestry individuals
Fasting glucose change (short-term)
8,195 European ancestry individuals
Diabetic maculopathy with decreased visual acuity in type 2 diabetes
469 Scottish ancestry cases, 1,374 Scottish ancestry controls
Affymetrix, Illumina [6717712] (imputed)
Diabetic maculopathy in type 2 diabetes
1,240 Scottish ancestry cases, 1,374 Scottish ancestry controls
Diastolic blood pressure x physical activity (least active quartile vs others) interaction (2df)
1,913 European ancestry inactive individuals, 4,792 European ancestry active individuals
Diastolic blood pressure x physical activity (less vs more active half) interaction (2df)
3,495 European ancestry inactive individuals, 3,210 European ancestry active individuals
Diastolic blood pressure x physical activity (least vs most active quartile) interaction (2df)
1,913 European ancestry inactive individuals, 2,071 European ancestry active individuals
Systolic blood pressure x physical activity (least active quartile vs others) interaction (2df)
Systolic blood pressure x physical activity (less vs more active half) interaction (2df)
Systolic blood pressure x physical activity (least vs most active quartile) interaction (2df)
Systolic blood pressure x physical activity interaction (2df)
6,705 European ancestry individuals
Diastolic blood pressure x physical activity (least active quartile vs others) interaction (1df)
Diastolic blood pressure x physical activity (less vs more active half) interaction (1df)
Diastolic blood pressure x physical activity (least vs most active quartile) interaction (1df)
Systolic blood pressure x physical activity (least active quartile vs others) interaction (1df)
Systolic blood pressure x physical activity (less vs more active half) interaction (1df)
Systolic blood pressure x physical activity (least vs most active quartile) interaction (1df)
Systolic blood pressure x physical activity interaction (1df)
Diastolic blood pressure x physical activity interaction (1df)
6,704 European ancestry individuals
DIastolic blood pressure x physical activity interaction (2df)
End-stage kidney disease
584 African American cases, 282 Hispanic cases, 112 East Asian cases, 96 Native Hawaiian cases, 1 American Indian cases, 30 cases, 8,429 African American controls, 15,852 Hispanic controls, 3,536 East Asian controls, 2,892 Native Hawaiian controls, 49 American Indian controls, 936 controls
Mild to moderate chronic kidney disease
1,532 African American cases, 1,336 Hispanic cases, 575 East Asian cases, 608 Native Hawaiian cases, 42 American Indian cases, 57 cases, 13,761 African American controls, 19,317 Hispanic controls, 3,540 East Asian controls, 2,892 Native Hawaiian controls, 595 American Indian controls, 936 controls
19,099 European ancestry cases, 72 non-European ancestry cases, 1,012 Han Chinese ancestry cases, 34,194 European ancestry controls, 72 non-European ancestry controls, 925 Han Chinese ancestry controls
5,085 Icelandic ancestry cases, 5,857 cases, 131,122 Icelandic ancestry controls, 70,393 controls
Affymetrix, Illumina, Perlegen [8047421] (imputed)
Frailty index
8,232 European ancestry individuals
5,248 European ancestry individuals
713 Japanese ancestry cases, 2,083 Japanese ancestry controls
770 Japanese ancestry cases, 852 Japanese ancestry controls
Appendicitis
18,773 European ancestry cases, 114,907 European ancestry controls
59 European ancestry cases, 607 European ancestry controls, 7,267 Icelandic ancestry cases, 327,134 Icelandic ancestry controls, 1,139 Dutch ancestry cases, 4,587 Dutch ancestry controls
Corpus callosum anterior volume
Cortex volume
Cerebral white matter volume
Sub-cortical grey matter volume
Total grey matter volume
Whole brain grey matter density
Total intracranial volume
Cerebellum white matter volume
Cerebellum cortex volume
Superior temporal sulcus banks volume
2,295 East Asian ancestry cases, 11,084 East Asian ancestry controls, 1,503 European ancestry cases, 18,594 European ancestry controls
2,737 East Asian ancestry cases, 56,815 East Asian ancestry controls, 1,421 European ancestry cases, 1,966 European ancestry controls
Affymetrix, Illumina [3493832] (imputed)
Allergic rhinitis x sex interaction
184 Danish ancestry male cases, 250 Danish ancestry female cases
472 European ancestry cases, 472 European ancestry controls
Cough x occupational exposure (biological dust, mineral dust, gases and fumes, pesticides, aromatic solvents, chlorinated solvents, other solvents or metals) interaction
675 Dutch ancestry cough cases, 7,301 Dutch ancestry controls
584 Dutch ancestry cough cases, 6,205 Dutch ancestry controls
Dyspnea x occupational exposure (biological dust, mineral dust, gases and fumes, pesticides, aromatic solvents, chlorinated solvents, other solvents or metals) interaction
547 Dutch ancestry dyspnea cases, 7,429 Dutch ancestry controls
505 Dutch ancestry dyspnea cases, 6,284 Dutch ancestry controls
Phlegm x occupational exposure (biological dust, mineral dust, gases and fumes, pesticides, aromatic solvents, chlorinated solvents, other solvents or metals) interaction
1,702 Dutch ancestry phlegm cases, 6,274 Dutch ancestry controls
1,405 Dutch ancestry phlegm cases, 5,384 Dutch ancestry controls
Mental health study participation (provided email address)
224,321 British ancestry cases, 147,096 British ancestry controls
Mental health study participation (completed survey)
122,647 British ancestry cases, 248,781 British ancestry controls
130,777 Japanese ancestry individuals
53,008 East Asian individuals, 105,253 European ancestry individuals
53,008 East Asian individuals, 105,253 Japanese ancestry individuals
22,566 Japanese ancestry cases, 28,226 Japanese ancestry controls
8,809 East Asian ancestry cases, 13,663 East Asian ancestry controls, 105,253 European ancestry individuals
Longevity (age >90th survival percentile)
11,262 European ancestry cases, 25,483 European ancestry controls
2,557 European ancestry cases, 4,987 European ancestry controls
Affymetrix, Illumina [up to 10786384] (imputed)
Longevity (age >99th survival percentile)
3,484 European ancestry cases, 2,178 East Asian ancestry cases, 25,483 European ancestry controls, 2,299 East Asian ancestry controls
11,262 European ancestry cases, 2,178 East Asian ancestry cases, 177 African American cases, 25,483 European ancestry controls, 2,299 East Asian ancestry controls, 211 African American controls.
3,484 European ancestry cases, 25,483 European ancestry controls
1,911 European ancestry cases, 4,987 European ancestry controls
White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure)
206 Finnish ancestry individuals
White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure)
Early onset periodontitis x smoking status interaction
499 European ancestry ever-smoker cases, 242 European ancestry never-smoker cases
341,584 European ancestry individuals
Ischemic heart disease
1,910 Korean ancestry cases, 11,945 Korean ancestry controls
33,598 Korean ancestry individuals
3,860 Chinese ancestry cases, 4,490 European ancestry cases, 13,328 Chinese ancestry controls, 14,027 European ancestry controls
8,762 Chinese ancestry cases, 6,819 European ancestry cases, 13,328 Chinese ancestry controls, 14,027 European ancestry controls
13,327 Chinese ancestry cases, 13,793 European ancestry cases, 13,328 Chinese ancestry controls, 14,027 European ancestry controls
2,277 African American cases, 3,098 East Asian ancestry cases, 3,704 European ancestry cases, 6,215 Hispanic/Latino cases, 2,939 South Asian ancestry cases, 2,283 African American controls, 2,921 East Asian ancestry controls, 3,514 European ancestry controls, 5,939 Hispanic/Latino controls, 3,022 South Asian ancestry controls
Affymetrix, Illumina [up to 35256845] (imputed)
Dental caries (decayed, missing and filled tooth surfaces)
109 African American adults
Dental caries (decayed, missing and filled teeth)
Dental caries (decayed and filled deciduous teeth)
96 African American children
Dental caries (decayed and filled deciduous tooth surfaces)
760 Central American ancestry individuals
up to 8,527 European ancestry individuals, 2,362 African American individuals, 1,447 Hispanic/Latino individuals
1,500 Cuban ancestry individuals
2,619 Mexican ancestry individuals
700 Dominican ancestry individuals
553 South American ancestry individuals
1,437 Puerto Rican ancestry individuals
3,637 Caribbean ancestry individuals
382 Hispanic/Latino cases, 7,015 Hispanic/Latino controls
Peripheral artery disease (borderline)
2,104 Hispanic/Latino cases, 5,293 Hispanic/Latino controls
7,589 Hispanic/Latino individuals
671 African American cases, 348 African American controls
969 African American cases, 1,287 African American controls
931 European ancestry cases, 228 African American ancestry cases, 14,210 European ancestry controls, 2,480 African American ancestry controls
931 European ancestry cases, 228 African American ancestry cases, 5,266 European ancestry controls, 1,817 African American ancestry controls
931 European ancestry cases, 14,210 European ancestry controls
11,762 European ancestry cases, 42,850 European ancestry controls
228 African American ancestry cases, 2,480 African American ancestry controls
5,071 African American ancestry cases, 11,081 African American ancestry controls
1,225 Mylopotamos (founder/genetic isolate) individuals
Liver disease biomarker
347,086 European ancestry individuals
BMI-adjusted waist-hip ratio variance
346,535 European ancestry individuals
Body fat percentage variance
341,632 European ancestry individuals
Basal metabolic rate variance
346,393 European ancestry individuals
Waist circumference variance
347,158 European ancestry individuals
Hip circumference variance
346,781 European ancestry individuals
Waist-hip ratio variance
347,134 European ancestry individuals
Height variance
Lung function (forced vital capacity) variance
317,222 European ancestry individuals
Lung function (FEV1) variance
317,285 European ancestry individuals
Lung function (FEV1/FVC) variance
316,614 European ancestry individuals
Heel bone mineral density variance
197,261 European ancestry individuals
Birth weight variance
197,758 European ancestry individuals
Predicted visceral adipose tissue
163,984 British ancestry men
161,168 British ancestry women
325,153 British ancestry individuals
866 European and unknown ancestry individuals
High chromosomal aberration frequency (chromatid type)
333 European and unknown ancestry cases, 533 European and unknown ancestry controls
High chromosomal aberration frequency (chromosome type)
High chromosomal aberration frequency (total) in genotoxic compound exposure
342 European and unknown ancestry cases, 265 European and unknown ancestry controls
Chromosomal aberration frequency (total) in genotoxic compound exposure
607 European and unknown ancestry individuals
High chromosomal aberration frequency (chromatid type) in genotoxic compound exposure
345 European and unknown ancestry cases, 262 European and unknown ancestry controls
Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure
High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure
321 European and unknown ancestry cases, 286 European and unknown ancestry controls
Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure
High chromosomal aberration frequency (total)
342 European and unknown ancestry genotoxic compound-exposed cases, 265 European and unknown ancestry genotoxic compound-exposed controls,255 European and unknown ancestry unexposed cases, 611 European and unknown ancestry unexposed controls
607 European and unknown ancestry genotoxic compound-exposed individuals, 866 European and unknown ancestry unexposed individuals
345 European and unknown ancestry genotoxic compound-exposed cases, 262 European and unknown ancestry genotoxic compound-exposed controls, 333 European and unknown ancestry unexposed cases, 533 European and unknown ancestry unexposed controls
321 European and unknown ancestry genotoxic compound-exposed cases, 286 European and unknown ancestry genotoxic compound-exposed controls, 333 European and unknown ancestry unexposed cases, 533 European and unknown ancestry unexposed controls
255 European and unknown ancestry cases, 611 European and unknown ancestry controls
Tendinopathy
181 European ancestry cases, 12 African American cases, 5 Brazilian cases, 1 Asian ancestry cases, 147 European ancestry controls, 9 African American controls, 7 Brazilian controls, 2 Asian ancestry controls
Stress-related phenotypes (multivariate analysis)
583 European and other ancestry individuals
547,361 European ancestry individuals
Affymetrix, Illumina [8603712] (imputed)
6,795 African American individuals
Affymetrix, Illumina [at least 8034757] (imputed)
51,541 European, African American, East Asian, South Asian or Hispanic ancestry individuals
Affymetrix, Illumina [8034757] (imputed)
51,861 European, African American, East Asian, South Asian or Hispanic ancestry cases, 297,093 European, African American, East Asian, South Asian or Hispanic ancestry controls
Affymetrix, Illumina [8326000] (imputed)
547,361 European ancestry individuals, 6,795 African American individuals, 6,324 East Asian ancestry individuals, 2,335 South Asian ancestry individuals, 1,442 Hispanic individuals
354 Saudi Arabian ancestry children
Verbal cognitive ability
Numerical cognitive ability
Figural/spatial cognitive ability
Macular thickness
59,814 European ancestry individuals
8,609 European ancestry individuals
Childhood body fatness
34,401 European ancestry individuals
Affymetrix, Illumina [10031233] (imputed)
CD20 on IgD+ CD38+ B cell
3,657 Sardinians individuals
CD20 on IgD+ CD38dim B cell
CD20 on IgD- CD24- B cell
CD20 on IgD- CD27- B cell
CD20 on IgD- CD38- B cell
CD20 on IgD- CD38+ B cell
3,659 Sardinians individuals
CD20 on IgD- CD38dim B cell
CD20 on memory B cell
CD20 on naive-mature B cell
CD20 on unswitched memory B cell
CD20 on switched memory B cell
CD20 on IgD+ B cell
3,658 Sardinians individuals
CD20 on transitional B cell
CD24 on CD24+ CD27+ B cell
3,654 Sardinians individuals
CD24 on IgD+ CD24+ B cell
3,655 Sardinians individuals
CD24 on IgD+ CD38- B cell
3,638 Sardinians individuals
CD24 on IgD+ CD38- unswitched memory B cell
1,832 Sardinians individuals
CD24 on IgD+ CD38+ B cell
CD24 on IgD- CD38- B cell
3,648 Sardinians individuals
CD24 on IgD- CD38dim B cell
3,649 Sardinians individuals
CD24 on memory B cell
3,653 Sardinians individuals
CD24 on unswitched memory B cell
CD24 on switched memory B cell
3,652 Sardinians individuals
CD24 on transitional B cell
3,656 Sardinians individuals
CD25 on B cell
3,660 Sardinians individuals
CD19 on IgD+ CD38- B cell
3,645 Sardinians individuals
CD19 on IgD+ CD38- naive B cell
1,830 Sardinians individuals
CD19 on IgD+ CD38- unswitched memory B cell
1,833 Sardinians individuals
CD19 on IgD+ CD38+ B cell
CD19 on IgD+ CD38dim B cell
CD19 on IgD- CD24- B cell
CD19 on IgD- CD38- B cell
CD19 on IgD- CD38+ B cell
CD19 on memory B cell
CD19 on naive-mature B cell
CD19 on unswitched memory B cell
CD19 on Plasma Blast-Plasma Cell
CD19 on switched memory B cell
CD19 on transitional B cell
CD20 on B cell
CD20 on CD20- CD38- B cell
3,606 Sardinians individuals
CD20 on CD24+ CD27+ B cell
CD20 on IgD+ CD38- naive B cell
1,834 Sardinians individuals
CD20 on IgD+ CD38- unswitched memory B cell
1,836 Sardinians individuals
CD25 on CD20- CD38- B cell
3,505 Sardinians individuals
CD25 on CD24+ CD27+ B cell
CD25 on IgD+ CD24+ B cell
CD25 on IgD+ CD24- B cell
CD25 on IgD+ CD38- B cell
3,642 Sardinians individuals
CD25 on IgD+ CD38- naive B cell
1,835 Sardinians individuals
CD25 on IgD+ CD38- unswitched memory B cell
1,837 Sardinians individuals
CD25 on IgD+ CD38+ B cell
CD25 on IgD+ CD38dim B cell
CD25 on IgD- CD24- B cell
CD25 on IgD- CD27- B cell
3,651 Sardinians individuals
CD25 on IgD- CD38- B cell
CD25 on IgD- CD38+ B cell
CD25 on IgD- CD38dim B cell
CD25 on memory B cell
CD25 on naive-mature B cell
CD25 on unswitched memory B cell
CD25 on switched memory B cell
CD27 on IgD- CD38dim B cell
CD27 on memory B cell
CD27 on unswitched memory B cell
CD27 on CD20- B cell
3,634 Sardinians individuals
CD38 on CD20- B cell
3,630 Sardinians individuals
CD38 on CD3- CD19-
CD38 on IgD+ CD24- B cell
CD38 on IgD+ CD38+ B cell
CD38 on IgD+ CD38dim B cell
CD38 on IgD- CD38+ B cell
3,644 Sardinians individuals
CD38 on IgD- CD38dim B cell
CD38 on naive-mature B cell
CD38 on Plasma Blast-Plasma Cell
CD38 on IgD+ B cell
CD38 on transitional B cell
IgD on IgD+ CD24+ B cell
IgD on IgD+ CD24- B cell
IgD on IgD+ CD38- B cell
IgD on IgD+ CD38- unswitched memory B cell
IgD on IgD+ CD38+ B cell
IgD on IgD+ CD38dim B cell
IgD on unswitched memory B cell
3,636 Sardinians individuals
CD3 on T cell
CD3 on CD39+ resting CD4 regulatory T cell
2,649 Sardinians individuals
CD3 on activated CD4 regulatory T cell
CD3 on CD39+ activated CD4 regulatory T cell
CD3 on secreting CD4 regulatory T cell
CD3 on CD39+ secreting CD4 regulatory T cell
CD3 on activated & secreting CD4 regulatory T cell
CD3 on CD45RA+ CD4+ T cell
CD3 on CD8+ T cell
CD3 on CD39+ CD4+ T cell
BAFF-R on CD20- B cell
CD3 on CD28+ CD45RA- CD8+ T cell
CD3 on CD28+ CD45RA+ CD8+ T cell
CD3 on CD28- CD8+ T cell
CD62L on CD62L+ Dendritic Cell
CD3 on CD4 regulatory T cell
CD3 on resting CD4 regulatory T cell
CD34 on Hematopoietic Stem Cell
CD66b on CD66b++ myeloid cell
1,465 Sardinians individuals
HVEM on naive CD8+ T cell
HVEM on Effector Memory CD8+ T cell
HVEM on Terminally Differentiated CD8+ T cell
CD3 on Effector Memory CD8+ T cell
CD3 on Terminally Differentiated CD8+ T cell
CD3 on Central Memory CD4+ T cell
CD3 on Naive CD4+ T cell
CD3 on Effector Memory CD4+ T cell
CD3 on Terminally Differentiated CD4+ T cell
CD3 on CD45RA- CD4+ T cell
CD3 on Central Memory CD8+ T cell
CD3 on HLA DR+ T cell
CD3 on Natural Killer T
CD3 on HLA DR+ CD4+ T cell
CD3 on HLA DR+ CD8+ T cell
CD19 on IgD- CD27- B cell
CD19 on IgD- CD38dim B cell
CD19 on IgD+ B cell
CD20 on IgD+ CD24+ B cell
CD20 on IgD+ CD24- B cell
CD20 on IgD+ CD38- B cell
IgD on IgD+ B cell
IgD on transitional B cell
BAFF-R on B cell
CD3 on CD28+ CD4+ T cell
CD3 on CD28+ CD4-CD8- T cell
CD62L on CD62L+ myeloid Dendritic Cell
CD62L on CD62L+ plasmacytoid Dendritic Cell
CD3 on CD39+ CD8+ T cell
CD3 on CD4+ T cell
CD62L on monocyte
CD62L on granulocyte
2,849 Sardinians individuals
HVEM on T cell
CD66b on Granulocytic Myeloid-Derived Suppressor Cells
CD3 on naive CD8+ T cell
HVEM on CD4+ T cell
CD27 on IgD+ CD38- unswitched memory B cell
CD27 on IgD- CD38- B cell
CD27 on IgD- CD38+ B cell
CD25 on IgD+ B cell
CD25 on transitional B cell
CD27 on Plasma Blast-Plasma Cell
CD27 on switched memory B cell
CD27 on CD20- CD38- B cell
3,592 Sardinians individuals
CD27 on CD24+ CD27+ B cell
CD27 on T cell
1,838 Sardinians individuals
CD27 on IgD+ CD24+ B cell
Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction)
248 European ancestry individuals
Alzheimer's disease or body fat percentage (pleiotropy)
100,716 individuals with body fat percentage measurements, 71,880 Alzheimer's disease cases, 383,378 controls
Alzheimer's disease or BMI (pleiotropy)
681,275 individuals with BMI measurements, 71,880 Alzheimer's disease cases, 383,378 controls
Alzheimer's disease or coronary heart disease (pleiotropy)
34,541 coronary heart disease cases, 71,880 Alzheimer's disease cases, 645,362 controls
Alzheimer's disease or diastolic blood pressure (pleiotropy)
1,006,863 individuals with diastolic blood pressure measurements, 71,880 Alzheimer's disease cases, 383,378 controls
404,128 European ancestry individuals with HDL-C measurements, 71,880 Alzheimer's disease cases, 383,378 controls
Alzheimer's disease or LDL levels (pleiotropy)
404,128 European ancestry individuals with LDL-C measurements, 71,880 Alzheimer's disease cases, 383,378 controls
Alzheimer's disease or systolic blood pressure (pleiotropy)
1,006,863 individuals with systolic blood pressure measurements, 71,880 Alzheimer's disease cases, 383,378 controls
Alzheimer's disease or total cholesterol levels (pleiotropy)
404,128 European ancestry individuals with total cholesterol measurements, 71,880 Alzheimer's disease cases, 383,378 controls
Alzheimer's disease or triglycerides levels (pleiotropy)
404,128 European ancestry individuals with triglyceride measurements, 71,880 Alzheimer's disease cases, 383,378 controls
80,831 type 2 diabetes cases, 71,880 Alzheimer's disease cases, 1,200,677 controls
Alzheimer's disease or waist-hip ratio (pleiotropy)
649,649 individuals with waist-hip ratio measurements, 71,880 Alzheimer's disease cases, 383,378 controls
17,416 European ancestry cases, 375,455 European ancestry controls
9,262 European ancestry individuals
Adiponectin levels (fat percentage adjusted)
216 African American cases, 105 European ancestry cases
47 Saudi Arab ancestry young male cases, 43 Saudi Arab ancestry young male controls
HOMA-B (corrected for HOMA-IR)
1,892 American Indian ancestry individuals
450,243 European ancestry individuals
205,513 European ancestry men
244,730 European ancestry women
86,413 Caucasian ancestry individuals
Affymetrix, Illumina [6052021] (imputed)
Methioninesulfoxide levels
23,469 Caucasian ancestry individuals
Affymetrix, Illumina [6093711] (imputed)
Asparagine levels
30,922 Caucasian ancestry individuals
Affymetrix, Illumina [6046450] (imputed)
Sarcosine levels
22,912 Caucasian ancestry individuals
Affymetrix, Illumina [6093787] (imputed)
Spermidine levels
16,699 Caucasian ancestry individuals
Affymetrix, Illumina [6090968] (imputed)
23,553 Caucasian ancestry individuals
Affymetrix, Illumina [6093547] (imputed)
Glutamate levels
30,977 Caucasian ancestry individuals
Affymetrix, Illumina [6046372] (imputed)
80,003 Caucasian ancestry individuals
Affymetrix, Illumina [6053131] (imputed)
Histidine levels
80,809 Caucasian ancestry individuals
Affymetrix, Illumina [6053918] (imputed)
86,404 Caucasian ancestry individuals
Affymetrix, Illumina [6052093] (imputed)
86,351 Caucasian ancestry individuals
Affymetrix, Illumina [6052280] (imputed)
Valerylcarnitine levels
Affymetrix, Illumina [6083606] (imputed)
Methionine levels
30,967 Caucasian ancestry individuals
Affymetrix, Illumina [6046489] (imputed)
Ornithine levels
30,920 Caucasian ancestry individuals
Phenylalanine levels
84,297 Caucasian ancestry individuals
Affymetrix, Illumina [6055439] (imputed)
Proline levels
30,985 Caucasian ancestry individuals
Affymetrix, Illumina [6046366] (imputed)
Serine levels
30,955 Caucasian ancestry individuals
Affymetrix, Illumina [6046388] (imputed)
Threonine levels
29,276 Caucasian ancestry individuals
Affymetrix, Illumina [6042426] (imputed)
Tryptophan levels
30,974 Caucasian ancestry individuals
Affymetrix, Illumina [6046425] (imputed)
86,507 Caucasian ancestry individuals
Affymetrix, Illumina [6036766] (imputed)
Dodecanoylcarnitine levels
28,569 Caucasian ancestry individuals
Affymetrix, Illumina [6042902] (imputed)
Acetylornithine levels
30,692 Caucasian ancestry individuals
Affymetrix, Illumina [6046508] (imputed)
Tetradecanoylcarnitine levels
23,445 Caucasian ancestry individuals
Affymetrix, Illumina [6093394] (imputed)
alpha-Aminoadipic acid levels
14,414 Caucasian ancestry individuals
Affymetrix, Illumina [6077382] (imputed)
84,794 Caucasian ancestry individuals
Affymetrix, Illumina [6050906] (imputed)
13,890 Korean ancestry individuals
Hyper-LDL-cholesterolemia
Hypo-HDL-cholesterolemia
Dyslipidemia
Facial morphology traits (63 three-dimensional facial segments)
1,719 European ancestry individuals
3 African American cases, 1 Asian ancestry case, 98 European ancestry cases, 6 African American controls, 1 Asian ancestry control, 4,118 European ancestry controls
1 African American case, 1 Asian ancestry case, 36 European ancestry cases, 1 African American control, 2 Asian ancestry controls, 461 European ancestry controls
IgD- CD38dim B cell %lymphocyte
IgD- CD38- B cell %lymphocyte
IgD- CD38dim B cell %B cell
IgD+ CD38+ B cell %lymphocyte
IgD+ CD38dim B cell %lymphocyte
IgD+ CD38- B cell %lymphocyte
Unswitched memory B cell %lymphocyte
IgD- CD27- B cell %lymphocyte
Switched memory B cell %lymphocyte
Plasma Blast-Plasma Cell %lymphocyte
Memory B cell %lymphocyte
Naive-mature B cell %lymphocyte
IgD- CD38dim B cell Absolute Count
IgD+ CD24+ B cell %lymphocyte
IgD- CD24- B cell %lymphocyte
IgD+ CD24- B cell %lymphocyte
CD24+ CD27+ B cell %lymphocyte
CD20- B cell %lymphocyte
CD20- CD38- B cell %lymphocyte
IgD- CD38- B cell %B cell
IgD- CD38- B cell Absolute Count
IgD+ CD38+ B cell %B cell
CD11c+ monocyte Absolute Count
3,020 Sardinians individuals
CD11c+ monocyte %monocyte
3,043 Sardinians individuals
CD62L- monocyte Absolute Count
CD39 on CD39+ CD4+ T cell
CD8 on CD8+ T cell
CD39 on monocyte
2,909 Sardinians individuals
CD8 on HLA DR+ CD8+ T cell
CD80 on CD62L+ myeloid Dendritic Cell
CD4 on CD28+ CD4+ T cell
CD80 on CD62L+ plasmacytoid Dendritic Cell
CD4 on resting CD4 regulatory T cell
CD80 on granulocyte
CD4 on activated CD4 regulatory T cell
CD45 on CD33+ HLA DR+ CD14-
CD4 on secreting CD4 regulatory T cell
CD45 on CD33dim HLA DR+ CD11b-
1,635 Sardinians individuals
CD4 on activated & secreting CD4 regulatory T cell
CD45 on CD33- HLA DR+
CD45 on Granulocytic Myeloid-Derived Suppressor Cells
SSC-A on plasmacytoid Dendritic Cell
SSC-A on monocyte
SSC-A on CD14+ monocyte
SSC-A on B cell
CD8 on Central Memory CD8+ T cell
SSC-A on HLA DR+ Natural Killer
SSC-A on granulocyte
SSC-A on lymphocyte
SSC-A on T cell
SSC-A on CD4+ T cell
SSC-A on CD8+ T cell
SSC-A on HLA DR+ T cell
SSC-A on Natural Killer T
SSC-A on HLA DR+ CD4+ T cell
SSC-A on HLA DR+ CD8+ T cell
CD11c on myeloid Dendritic Cell
CD11c on CD62L+ myeloid Dendritic Cell
CD11c on monocyte
CD11c on granulocyte
CD11b on CD14+ monocyte
CD11b on Granulocytic Myeloid-Derived Suppressor Cells
CD11b on CD66b++ myeloid cell
CD11b on Monocytic Myeloid-Derived Suppressor Cells
CD11b on CD33dim HLA DR-
1,559 Sardinians individuals
CD11b on basophil
1,556 Sardinians individuals
CD11b on CD33+ HLA DR+ CD14dim
CD45RA on naive CD4+ T cell
CD4RA on Terminally Differentiated CD4+ T cell
CD45RA on naive CD8+ T cell
CD45RA on Terminally Differentiated CD8+ T cell
CD45RA on resting CD4 regulatory T cell
CD45RA on CD39+ resting CD4 regulatory T cell
HLA DR on myeloid Dendritic Cell
HLA DR on plasmacytoid Dendritic Cell
HLA DR on Dendritic Cell
CD8 on Terminally Differentiated CD8+ T cell
CD39 on granulocyte
CD8 on Natural Killer T
3,103 Sardinians individuals
CD80 on myeloid Dendritic Cell
CD4 on CD39+ CD4+ T cell
CD80 on plasmacytoid Dendritic Cell
CD4 on CD4 regulatory T cell
CD80 on monocyte
CD4 on CD39+ resting CD4 regulatory T cell
CD4 on CD39+ activated CD4 regulatory T cell
CD45 on CD33+ HLA DR+ CD14dim
CD4 on CD39+ secreting CD4 regulatory T cell
CD45 on CD33- HLA DR-
SSC-A on myeloid Dendritic Cell
CD45 on CD66b++ myelod cell
CD45 on Monocytic Myeloid-Derived Suppressor Cells
CD45 on CD33dim HLA DR-
CD45 on basophil
CD45 on Immature Myeloid-Derived Suppressor Cells
CD45 on CD33+ HLA DR+
1,580 Sardinians individuals
SSC-A on Natural Killer
CD8 on naive CD8+ T cell
CD8 on Effector Memory CD8+ T cell
HLA DR on Hematopoietic Stem Cell
HLA DR on CD33+ HLA DR+ CD14-
HLA DR on CD33+ HLA DR+ CD14dim
HLA DR on CD33dim HLA DR+ CD11b+
HLA DR on CD33dim HLA DR+ CD11b-
HLA DR on CD33- HLA DR+
HLA DR on HLA DR+ T cell
HLA DR on HLA DR+ CD4+ T cell
HLA DR on HLA DR+ CD8+ T cell
HLA DR on B cell
HLA DR on HLA DR+ Natural Killer
CD8 on CD28+ CD45RA- CD8+ T cell
CD8 on CD28+ CD45RA+ CD8+ T cell
CD8 on CD28- CD8+ T cell
CD8 on CD39+ CD8+ T cell
IgD+ B cell %B cell
IgD+ CD38+ B cell Absolute Count
IgD+ CD38dim B cell %B cell
IgD+ CD38dim B cell Absolute Count
IgD+ CD38- B cell %B cell
IgD+ CD38- B cell Absolute Count
Unswitched memory B cell %B cell
Unswitched memory B cell Absolute Count
IgD- CD27- B cell %B cell
IgD+ B cell Absolute Count
IgD- CD27- B cell Absolute Count
Switched memory B cell %B cell
Switched memory B cell Absolute Count
Plasma Blast-Plasma Cell %B cell
Plasma Blast-Plasma Cell Absolute Count
Memory B cell %B cell
Memory B cell Absolute Count
Naive-mature B cell %B cell
Naive-mature B cell Absolute Count
IgD- CD38+ B cell %B cell
IgD+ CD24+ B cell %B cell
IgD+ CD24+ B cell Absolute Count
IgD- CD24- B cell %B cell
IgD- CD24- B cell Absolute Count
IgD+ CD24- B cell %B cell
IgD+ CD24- B cell Absolute Count
CD24+ CD27+ B cell %B cell
CD24+ CD27+ B cell Absolute Count
CD20- B cell %B cell
IgD- CD38+ B cell Absolute Count
CD20- B cell Absolute Count
CD20- CD38- B cell %B cell
CD20- CD38- B cell Absolute Count
IgD+ B cell %Lymphocyte
IgD- CD38+ B cell %lymphocyte
Pneumonia severity
5,774 European ancestry inpatients, 1,043 African ancestry inpatients, 3,115 European ancestry outpatients, 667 African ancestry outpatients
850 European ancestry inpatients, 220 African ancestry inpatients, 274 European ancestry outpatients, 72 African ancestry outpatients
8,889 European ancestry cases, 1,710 African ancestry cases, 60,767 European ancestry controls, 13,871 African ancestry controls
8,805 European ancestry cases, 368 African ancestry cases, 447,334 European ancestry controls, 10,417 African ancestry controls
Body fat percentage and HDL-C (pairwise)
277,811 European ancestry individuals, 10,022 East Asian, South Asian and African American ancestry individuals
Affymetrix, Illumina [2331072] (imputed)
Body fat percentage and LDL-C (pairwise)
263,726 European ancestry individuals, 10,061 East Asian, South Asian and African American ancestry individuals
Body fat percentage and triglycerides (pairwise)
268,505 European ancestry individuals, 10,072 East Asian, South Asian and African American ancestry individuals
Body fat percentage and fasting insulin (pairwise)
142,394 European ancestry individuals, 10,072 East Asian, South Asian and African American ancestry individuals
Body fat percentage and fasting glucose (pairwise)
148,718 European ancestry individuals, 10,072 East Asian, South Asian and African American ancestry individuals
Body fat percentage and systolic blood pressure (pairwise)
240,784 European ancestry individuals, 10,072 East Asian, South Asian and African American ancestry individuals
Body fat percentage and coronary artery disease (pairwise)
232,558 European ancestry individuals, 52,463 East Asian, South Asian, Middle Eastern, Hispanic and African American ancestry individuals
Body fat percentage and type 2 diabetes (pairwise)
200,863 European ancestry individuals, 24,401 East Asian, South Asian and African American ancestry individuals
Body mass index and HDL-C (pairwise)
509,429 European ancestry individuals, 16,962 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and LDL-C (pairwise)
495,344 European ancestry individuals,16,962 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and triglycerides (pairwise)
500,123 European ancestry individuals,16,962 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and fasting insulin (pairwise)
374,012 European ancestry individuals, 16,962 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and fasting glucose (pairwise)
380,336 European ancestry individuals, 16,962 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and systole blood pressure (pairwise)
472,402 European ancestry individuals, 16,962 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and coronary artery disease (pairwise)
464,176 European ancestry individuals, 59,353 East Asian, South Asian, Hispanic and African American ancestry individuals
Body mass index and type 2 diabetes (pairwise)
418,152 European ancestry individuals, 31,291 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and HDL-C (pairwise)
402,477 European ancestry individuals, 11,333 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and LDL-C (pairwise)
388,392 European ancestry individuals, 11,333 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and triglycerides (pairwise)
393,171 European ancestry individuals, 11,333 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and fasting insulin (pairwise)
267,060 European ancestry individuals, 11,333 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and fasting glucose (pairwise)
273,384 European ancestry individuals, 11,333 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and systolic blood pressure (pairwise)
365,450 European ancestry individuals, 11,333 East Asian, South Asian, Hispanic and African American ancestry individuals
Waist-hip ratio and coronary artery disease (pairwise)
357,224 European ancestry individuals, 53,724 East Asian, South Asian, Middle Eastern, Hispanic and African American ancestry individuals
Waist-hip ratio and type 2 diabetes (pairwise)
311,200 European ancestry individuals, 25,662 East Asian, South Asian, Hispanic and African American ancestry individuals
395 African American individuals
681 African American individuals
Affymetrix, Illumina [7169107] (imputed)
417,580 European ancestry individuals
80,998 European ancestry individuals, 1,632 individuals
496,946 European ancestry individuals
177,082 European ancestry individuals
162,591 European ancestry individuals
Serum 25-Hydroxyvitamin D level variance
318,851 European ancestry individuals
Serum 25-Hydroxyvitamin D levels x season interaction
339,673 European ancestry individuals
Endometriosis or depression (pleiotropy)
17,054 endometriosis cases, 170,756 European ancestry depression cases, 191,858 controls, 329,443 European ancestry controls
TNF-related activation-induced cytokine levels
C-C motif chemokine 4 levels
C-X-C motif chemokine 6 levels
Melusin levels
SIR2-like protein 2 levels
Tumor necrosis factor receptor superfamily member 5 levels
Endothelial cell-specific molecule 1 levels
Ultradistal forearm bone mineral density
21,907 European ancestry individuals
20,806 European ancestry cases, 59,804 European ancestry controls
4,159 cases, 18,650 controls
Asthma (moderate or severe)
5,135 European ancestry cases, 25,675 European ancestry controls
5,414 European ancestry cases, 21,471 European ancestry controls
Response to cognitive-behavioural therapy in anxiety and major depressive disorders
972 European ancestry adult anxiety disorder cases, 832 adult major depressive disorder cases, 920 child anxiety disorder cases
920 child cases
972 European ancestry adult cases
Response to cognitive-behavioural therapy in major depressive disorder
832 adult cases
Diabetic peripheral neuropathy in type 2 diabetes
4,384 European ancestry cases, 784 European ancestry controls
791 European ancestry cases, 158 European ancestry controls, 1,345 African American individuals
Affymetrix, Illumina [6847206] (imputed)
Mental health related quality of life
1,386 European ancestry individuals, 56 individuals
Physical health related quality of life
382,867 British ancestry individuals
417,522 British ancestry individuals
419,516 British ancestry individuals
384,986 British ancestry individuals
Direct low density lipoprotein cholesterol levels
418,780 British ancestry individuals
334,646 British ancestry individuals
419,185 British ancestry individuals
384,915 British ancestry individuals
Intermediate age-related macular degeneration
5,336 European ancestry cases, 14,590 European ancestry controls
8,544 European ancestry cases, 14,590 European ancestry controls
2,656 European ancestry cases, 14,590 European ancestry controls
CD28- CD25++ CD8+ T cell %T cell
3,162 Sardinians individuals
CD28- CD25++ CD8+ T cell %CD8+ T cell
CD28- CD25++ CD8+ T cell Absolute Count
3,130 Sardinians individuals
CD25++ CD8+ T cell %T cell
CD25++ CD8+ T cell %CD8+ T cell
CD25++ CD8+ T cell Absolute Count
CD127- CD8+ T cell %T cell
3,403 Sardinians individuals
CD127- CD8+ T cell %CD8+ T cell
CD127- CD8+ T cell Absolute Count
3,371 Sardinians individuals
CD28- CD8+ T cell %T cell
3,440 Sardinians individuals
CD28- CD8+ T cell %CD8+ T cell
CD28- CD8+ T cell Absolute Count
3,408 Sardinians individuals
CD28+ CD45RA+ CD8+ T cell %T cell
CD28+ CD45RA+ CD8+ T cell %CD8+ T cell
CD28+ CD45RA+ CD8+ T cell Absolute Count
CD28+ CD45RA- CD8+ T cell %T cell
CD28+ CD45RA- CD8+ T cell %CD8+ T cell
CD28+ CD45RA- CD8+ T cell Absolute Count
CD28- CD4-CD8- T cell %T cell
CD45RA- CD28- CD8+ T cell Absolute Count
CD45RA- CD28- CD8+ T cell %CD8+ T cell
3,425 Sardinians individuals
CD45RA- CD28- CD8+ T cell %T cell
CD45RA+ CD28- CD8+ T cell Absolute Count
CD45RA+ CD28- CD8+ T cell %CD8+ T cell
CD45RA+ CD28- CD8+ T cell %T cell
BAFF-R on CD20- CD38- B cell
BAFF-R on CD24+ CD27+ B cell
BAFF-R on IgD+ CD24+ B cell
BAFF-R on IgD+ CD24- B cell
BAFF-R on IgD+ CD38- B cell
BAFF-R on IgD+ CD38- naive B cell
BAFF-R on IgD+ CD38- unswitched memory B cell
BAFF-R on IgD+ CD38+ B cell
BAFF-R on IgD+ CD38dim B cell
BAFF-R on IgD- CD24- B cell
BAFF-R on IgD- CD27- B cell
BAFF-R on IgD- CD38- B cell
BAFF-R on IgD- CD38+ B cell
BAFF-R on IgD- CD38dim B cell
BAFF-R on memory B cell
BAFF-R on naive-mature B cell
BAFF-R on unswitched memory B cell
BAFF-R on switched memory B cell
BAFF-R on IgD+ B cell
BAFF-R on transitional B cell
CD19 on CD20- B cell
CD19 on CD20- CD38- B cell
CD19 on CD24+ CD27+ B cell
CD19 on IgD+ CD24+ B cell
CD19 on IgD+ CD24- B cell
Granulocyte Absolute Count
Granulocyte %leukocyte
3,669 Sardinians individuals
CD28- CD4-CD8- T cell %CD4-CD8- T cell
CD28- CD4-CD8- T cell Absolute Count
CD28+ CD4-CD8- T cell %T cell
CD28+ CD4-CD8- T cell %CD4-CD8- T cell
CD28+ CD4-CD8- T cell Absolute Count
CD39+ CD4+ T cell %T cell
CD39+ CD4+ T cell %CD4+ T cell
CD39+ CD4+ T cell Absolute Count
CD28- CD8dim T cell %T cell
CD28- CD8dim T cell %CD8dim T cell
CD28- CD8dim T cell Absolute Count
CD28+ CD45RA+ CD8dim T cell %T cell
CD28+ CD45RA+ CD8dim T cell %CD8dim T cell
CD28+ CD45RA+ CD8dim T cell Absolute Count
CD28+ CD45RA- CD8dim T cell %T cell
CD28+ CD45RA- CD8dim T cell %CD8dim T cell
CD28+ CD45RA- CD8dim T cell Absolute Count
CD39+ CD8+ T cell %T cell
CD39+ CD8+ T cell %CD8+ T cell
CD39+ CD8+ T cell Absolute Count
CD28- CD127- CD25++ CD8+ T cell %T cell
CD28- CD127- CD25++ CD8+ T cell %CD8+ T cell
CD28- CD127- CD25++ CD8+ T cell Absolute Count
Naive CD8+ T cell Absolute Count
Naive CD8+ T cell %CD8+ T cell
Naive CD8+ T cell %T cell
Effector Memory CD8+ T cell Absolute Count
Effector Memory CD8+ T cell %CD8+ T cell
Effector Memory CD8+ T cell %T cell
Terminally Differentiated CD8+ T cell Absolute Count
Terminally Differentiated CD8+ T cell %CD8+ T cell
Terminally Differentiated CD8+ T cell %T cell
CD45RA+ CD8+ T cell Absolute Count
CD45RA+ CD8+ T cell %CD8+ T cell
CD45RA+ CD8+ T cell %T cell
Central Memory CD4-CD8- T cell Absolute Count
Central Memory CD4-CD8- T cell %CD4-CD8- T cell
Central Memory CD4-CD8- T cell %T cell
Naive CD4-CD8- T cell Absolute Count
Naive CD4-CD8- T cell %CD4-CD8- T cell
Naive CD4-CD8- T cell %T cell
Effector Memory CD4-CD8- T cell Absolute Count
Effector Memory CD4-CD8- T cell %CD4-CD8- T cell
Effector Memory CD4-CD8- T cell %T cell
Terminally Differentiated CD4-CD8- T cell Absolute Count
Terminally Differentiated CD4-CD8- T cell %CD4-CD8- T cell
Terminally Differentiated CD4-CD8- T cell %T cell
Naive CD4+ T cell %T cell
HLA DR+ CD4+ T cell %lymphocyte
HLA DR+ CD8+ T cell Absolute Count
HLA DR+ CD8+ T cell %T cell
HLA DR+ CD8+ T cell %lymphocyte
CD8+ Natural Killer T Absolute Count
CD8+ Natural Killer T %T cell
3,668 Sardinians individuals
CD8+ Natural Killer T %lymphocyte
CD8dim Natural Killer T Absolute Count
CD8dim Natural Killer T %T cell
CD8dim Natural Killer T %lymphocyte
CD4-CD8- Natural Killer T Absolute Count
CD4-CD8- Natural Killer T %T cell
CD4-CD8- Natural Killer T %lymphocyte
CD3- lymphocyte Absolute Count
CD3- lymphocyte %lymphocyte
CD3- lymphocyte %leukocyte
B cell Absolute Count
B cell %CD3- lymphocyte
B cell %lymphocyte
Natural Killer Absolute Count
Natural Killer %CD3- lymphocyte
Natural Killer %lymphocyte
HLA DR+ Natural Killer Absolute Count
3,580 Sardinians individuals
HLA DR+ Natural Killer %Natural Killer
3,596 Sardinians individuals
HLA DR+ Natural Killer %CD3- lymphocyte
Lymphocyte Absolute Count
Lymphocyte %leukocyte
T cell Absolute Count
T cell %lymphocyte
T cell %leukocyte
CD4+ T cell %leukocyte
CD8+ T cell %leukocyte
CD4+CD8+ T cell %leukocyte
CD4+ CD8dim T cell Absolute Count
CD4+ CD8dim T cell %lymphocyte
CD4+ CD8dim T cell %leukocyte
CD8dim T cell %leukocyte
CD4-CD8- T cell %leukocyte
CD8+ and CD8dim T cell %leukocyte
TCRgd T cell Absolute Count
3,650 Sardinians individuals
TCRgd T cell %T cell
3,666 Sardinians individuals
TCRgd T cell %lymphocyte
HLA DR+ T cell Absolute Count
HLA DR+ T cell%T cell
HLA DR+ T cell%lymphocyte
Natural Killer T Absolute Count
Natural Killer T %T cell
Natural Killer T %lymphocyte
HLA DR+ CD4+ T cell Absolute Count
HLA DR+ CD4+ T cell %T cell
Transitional B cell %B cell
Transitional B cell Absolute Count
Transitional B cell %lymphocyte
CD14- CD16+ monocyte Absolute Count
CD14+ CD16+ monocyte Absolute Count
CD14- CD16- Absolute Count
CD14+ CD16- monocyte Absolute Count
Monocyte Absolute Count
CD14- CD16+ monocyte %monocyte
CD14+ CD16+ monocyte %monocyte
CD14+ CD16- monocyte %monocyte
CD16+ monocyte %monocyte
T/B cell
CD4+/CD8+ T cell
CD4+ T cell Absolute Count
CD4+ T cell %T cell
CD8+ T cell Absolute Count
CD8+ T cell %T cell
CD4+CD8+ T cell Absolute Count
CD4+CD8+ T cell %T cell
CD8dim T cell Absolute Count
CD8dim T cell %T cell
CD4-CD8- T cell Absolute Count
CD4-CD8- T cell %T cell
Leukocyte Absolute Count
335,660 European ancestry individuals, 69,909 individuals
210,088 European ancestry individuals, 14,371 individuals
3,305 European ancestry cases, 9,196 European ancestry controls
2,751 European ancestry cases, 15,886 European ancestry controls
C-C motif chemokine 20 levels
Ovarian cancer-related tumor marker CA 125 levels
N-terminal prohormone brain natriuretic peptide levels
2,591 European ancestry cases, 4,027 European ancestry controls
394,929 European ancestry individuals
11,502 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [35912980] (imputed)
474,001 European ancestry individuals
Affymetrix, Illumina [50036608] (imputed)
81,042 East Asian ancestry individuals
Affymetrix, Illumina [16286709] (imputed)
2,969 Hispanic or Latin American individuals
Affymetrix, Illumina [23758884] (imputed)
8,149 South Asian ancestry individuals
Affymetrix, Illumina [28457669] (imputed)
577,663 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [19905671] (imputed)
11,615 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [35935203] (imputed)
474,237 European ancestry individuals
Affymetrix, Illumina [50000174] (imputed)
86,890 East Asian ancestry individuals
Affymetrix, Illumina [16279099] (imputed)
2,966 Hispanic or Latin American individuals
Affymetrix, Illumina [23758042] (imputed)
8,142 South Asian ancestry individuals
Affymetrix, Illumina [28445528] (imputed)
583,850 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [19872809] (imputed)
15,134 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36870619] (imputed)
562,259 European ancestry individuals
Affymetrix, Illumina [50640577] (imputed)
142,940 East Asian ancestry individuals
Affymetrix, Illumina [16289021] (imputed)
9,301 Hispanic or Latin American individuals
Affymetrix, Illumina [26810352] (imputed)
Affymetrix, Illumina [28493283] (imputed)
737,823 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [24558453] (imputed)
15,133 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36870618] (imputed)
563,946 European ancestry individuals
Affymetrix, Illumina [50638016] (imputed)
149,861 East Asian ancestry individuals
Affymetrix, Illumina [16709126] (imputed)
Affymetrix, Illumina [28493177] (imputed)
746,431 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [24653286] (imputed)
13,477 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36456147] (imputed)
Affymetrix, Illumina [28493162] (imputed)
727,624 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [24332387] (imputed)
13,519 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36660117] (imputed)
531,774 European ancestry individuals
Affymetrix, Illumina [49860007] (imputed)
8,526 Hispanic or Latin American individuals
Affymetrix, Illumina [26792043] (imputed)
8,166 South Asian ancestry individuals
Affymetrix, Illumina [28471494] (imputed)
563,352 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [22063850] (imputed)
15,061 African American or Afro-Caribbean and African ancestry individuals
Affymetrix, Illumina [36864690] (imputed)
562,243 European ancestry individuals
Affymetrix, Illumina [50601830] (imputed)
151,807 East Asian ancestry individuals
Affymetrix, Illumina [16710636] (imputed)
9,368 Hispanic or Latin American individuals
Affymetrix, Illumina [26925380] (imputed)
Affymetrix, Illumina [28492541] (imputed)
746,667 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals
Affymetrix, Illumina [24649327] (imputed)
408,112 British individuals
approximately 344,000 European ancestry individuals
approximately 422,000 European ancestry individuals
up to 1,131,881 European ancestry individuals
Affymetrix, Illumina [10000000] (imputed)
Educational attainment (MTAG)
1,311,438 European ancestry individuals
Affymetrix, Illumina [7100000] (imputed)
257,841 European ancestry individuals
Affymetrix, Illumina [10100000] (imputed)
Cognitive performance (MTAG)
402,382 European ancestry individuals
Self-reported math ability
564,698 European ancestry individuals
Self-reported math ability (MTAG)
670,471 European ancestry individuals
Highest math class taken
430,445 European ancestry individuals
Highest math class taken (MTAG)
811,539 European ancestry individuals
Mean reticulocyte volume
Mean spheric corpuscular volume
approximately 455,000 European ancestry individuals
Balding type 1
approximately 208,000 European ancestry individuals
approximately 458,000 European ancestry individuals
approximately 446,000 European ancestry individuals
approximately 440,000 European ancestry individuals
approximately 443,000 European ancestry individuals
approximately 445,000 European ancestry individuals
approximately 444,000 European ancestry individuals
approximately 459,000 European ancestry individuals
Cardiovascular disease
Respiratory diseases
approximately 242,000 European ancestry individuals
approximately 143,000 European ancestry individuals
approximately 370,000 European ancestry individuals
approximately 372,000 European ancestry individuals
approximately 452,000 European ancestry individuals
approximately 410,000 European ancestry individuals
Smoking status
Electrocardiogram morphology (amplitude at temporal datapoints)
63,706 European and unknown ancestry individuals