plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref50

http://identifiers.org/pubmed/12857742
type: PublicationXref
id: 12857742
author: StrÃ¼bing, C
author: Krapivinsky, G
author: Clapham, DE
author: Krapivinsky, L
db: Pubmed
title: Formation of novel TRPC channels by complex subunit interactions in embryonic brain
source: J Biol Chem 278:39014-9
year: 2003

p-S67-Ensa/p-S67-Arpp19:PP2A-Ppp2r2d
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry6
component stoichiometry: Stoichiometry7
component: Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
component: p-S67-Ensa/p-S67-Arpp19
xref: UnificationXref47
xref: UnificationXref46
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445084

Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry4
component stoichiometry: Stoichiometry3
component stoichiometry: Stoichiometry5
component: PP2A-subunit A
component: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
component: PP2A-catalytic subunit C
name: PP2A complex (containing Ppp2r2d)
xref: UnificationXref44
xref: UnificationXref45
cellular location: nucleoplasm
display name: PP2A-Ppp2r2d
comment: Reactome DB_ID: 2445055

Smc2:Smc4:Ncapd2:Ncapg:Ncaph
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry12
component stoichiometry: Stoichiometry14
component stoichiometry: Stoichiometry13
component stoichiometry: Stoichiometry11
component stoichiometry: Stoichiometry10
component: XCAP-E
component: Structural maintenance of chromosomes protein 4
component: Condensin complex subunit 3
component: Condensin complex subunit 2
component: XCAP-D2
xref: UnificationXref88
xref: UnificationXref87
cellular location: cytosol
display name: Condensin I
comment: Reactome DB_ID: 2520852

Cerberus:Nodal
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry8
component stoichiometry: Stoichiometry9
component: CER1_XENLA
component: NODAL_XENLA
xref: UnificationXref68
xref: UnificationXref69
cellular location: extracellular region
comment: Reactome DB_ID: 1181343

p-T161-Cdk1:Ccnb
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry22
component stoichiometry: Stoichiometry23
component: Ccnb
component: p-T161-Cdk1
xref: UnificationXref121
xref: UnificationXref120
cellular location: cytosol
display name: MPF
comment: Reactome DB_ID: 2520869

Smc2:Smc4:p-T1314,1348,1353-Ncapd2:Ncaph:Ncapg
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry16
component stoichiometry: Stoichiometry20
component stoichiometry: Stoichiometry19
component stoichiometry: Stoichiometry18
component stoichiometry: Stoichiometry17
component: XCAP-E
component: p-xCAP-G
component: Structural maintenance of chromosomes protein 4
component: p-xCAP-H
component: p-T1314,1348,1353-XCAP-D2
xref: UnificationXref100
xref: UnificationXref99
cellular location: cytosol
display name: p-Condensin I
comment: Reactome DB_ID: 2520849

Xenopus unwinding complex at replication fork
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry30
component stoichiometry: Stoichiometry29
component stoichiometry: Stoichiometry31
component stoichiometry: Stoichiometry28
component: xCdc45
component: xMcm8
component: Replication Fork
component: xGINS complex
xref: UnificationXref148
xref: UnificationXref147
cellular location: nucleoplasm
comment: Reactome DB_ID: 176972

xGINS complex
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry27
component stoichiometry: Stoichiometry25
component stoichiometry: Stoichiometry26
component: xPSF2p
component: xPSF3p
component: xPSF1p
component: xSLD5P
xref: UnificationXref145
xref: UnificationXref146
cellular location: nucleoplasm
comment: Reactome DB_ID: 176953

Xklp2 dimer
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry2
component: kif15-a
xref: UnificationXref6
xref: UnificationXref7
cellular location: cytosol
comment: Reactome DB_ID: 984831

ccnb2
type: ProteinReference
name: UniProt:P13351 ccnb2
xref: UnificationXref107
comment: FUNCTION Essential for the control of the cell cycle at the G2/M (mitosis) transition.SUBUNIT Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdk1, interacts with spdya. Interacts with nap1l1.DEVELOPMENTAL STAGE Accumulates steadily during G2 and is abruptly destroyed at mitosis.SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily.
organism: Xenopus laevis

UniProt:P13350 ccnb1
type: ProteinReference
name: ccnb1
xref: UnificationXref104
comment: FUNCTION Essential for the control of the cell cycle at the G2/M (mitosis) transition.SUBUNIT Interacts with the cdc2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdc2, interacts with spdya. Interacts with nap1l1. Interacts with nanos1.DEVELOPMENTAL STAGE Accumulates steadily during G2 and is abruptly destroyed at mitosis.SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily.
organism: Xenopus laevis

xPSF1p
type: Protein
entity reference: gins2
data source: Reactome
xref: UnificationXref138
xref: UnificationXref137
cellular location: nucleoplasm
comment: Reactome DB_ID: 176946

xCdc45
type: Protein
entity reference: cdc45
data source: Reactome
xref: UnificationXref135
xref: UnificationXref134
cellular location: nucleoplasm
comment: Reactome DB_ID: 176954

p-T161-Cdk1-B
type: Protein
entity reference: cdk1-b
data source: Reactome
xref: UnificationXref116
xref: UnificationXref117
feature: ModificationFeature10
feature: FragmentFeature22
cellular location: cytosol
comment: Reactome DB_ID: 2520864

TRPC1_Xenopus
type: Protein
entity reference: trpc1
data source: Reactome
xref: UnificationXref55
xref: UnificationXref56
cellular location: plasma membrane
comment: Reactome DB_ID: 622401
display name: xtrpc1

http://identifiers.org/pubmed/9813089
type: PublicationXref
id: 9813089
author: Boleti, H
author: Wittmann, T
author: Vernos, I
author: Antony, C
author: Karsenti, E
db: Pubmed
title: Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
source: J Cell Biol 143:673-85
year: 1998

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: Protein
entity reference: ppp2r2d
data source: Reactome
name: pp2a subunit B isoform B55-delta
xref: UnificationXref43
xref: UnificationXref42
feature: FragmentFeature8
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445064
display name: Ppp2r2d

Ppp2r1b
type: Protein
entity reference: ppp2r1b
data source: Reactome
xref: UnificationXref38
xref: UnificationXref37
feature: FragmentFeature7
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445062

Ppp2r1a
type: Protein
entity reference: ppp2r1a
data source: Reactome
xref: UnificationXref35
xref: UnificationXref34
feature: FragmentFeature6
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445058

NODAL_XENLA
type: Protein
entity reference: nodal
data source: Reactome
xref: UnificationXref66
xref: UnificationXref67
feature: FragmentFeature10
cellular location: extracellular region
comment: Reactome DB_ID: 1181119
display name: nodal

Structural maintenance of chromosomes protein 4
type: Protein
entity reference: capc
data source: Reactome
name: XCAP-C
xref: UnificationXref73
xref: UnificationXref74
feature: FragmentFeature11
cellular location: cytosol
comment: Reactome DB_ID: 2520839
display name: Smc4

Activated xtrpc1
type: Protein
entity reference: trpc1
data source: Reactome
xref: UnificationXref57
xref: UnificationXref58
cellular location: plasma membrane
comment: Reactome DB_ID: 622399

CER1_XENLA
type: Protein
entity reference: UniProt:P70041 cer1
data source: Reactome
xref: UnificationXref63
xref: UnificationXref64
feature: FragmentFeature9
cellular location: extracellular region
comment: Reactome DB_ID: 1181319
display name: cer1

cytosol
type: CellularLocationVocabulary
xref: UnificationXref1

Condensin complex subunit 3
type: Protein
entity reference: capg
data source: Reactome
name: xCAP-G
xref: UnificationXref77
xref: UnificationXref76
feature: FragmentFeature12
cellular location: cytosol
comment: Reactome DB_ID: 2520848
display name: Ncapg

XCAP-E
type: Protein
entity reference: UniProt:P50533 smc2
data source: Reactome
name: Structural maintenance of chromosomes protein 2
xref: UnificationXref80
xref: UnificationXref79
feature: FragmentFeature13
cellular location: cytosol
comment: Reactome DB_ID: 2520844
display name: Smc2

Condensin complex subunit 2
type: Protein
entity reference: caph
data source: Reactome
name: xCAP-H
xref: UnificationXref83
xref: UnificationXref82
feature: FragmentFeature14
cellular location: cytosol
comment: Reactome DB_ID: 2520846
display name: Ncaph

p-xCAP-H
type: Protein
entity reference: caph
data source: Reactome
xref: UnificationXref94
xref: UnificationXref93
feature: FragmentFeature16
feature: ModificationFeature4
cellular location: cytosol
comment: Reactome DB_ID: 2520850
display name: p-Ncaph

Catalysis2
type: Catalysis
data source: Reactome
controlled: Xenopus Mcm8 mediated fork unwinding
control type: ACTIVATION
xref: RelationshipXref4
xref: RelationshipXref3
controller: xMcm8

UniProt:P70041 cer1
type: ProteinReference
name: cer
name: cer1
xref: UnificationXref62
comment: FUNCTION Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction. Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm.SUBUNIT The long chain interacts with nodal/nr-1, bmp4 and wnt8, thereby inhibiting their function. The short chain interacts with nodal/nr-1 but not bmp4 or wnt8.TISSUE SPECIFICITY A component of the Nieuwkoop signaling center in the blastula. Expressed transiently in a broad anterior domain of the gastrula, including the anterior endoderm of the Spemann's organizer and more laterally the cardiac primordia. Expression is excluded from the prospective prechordal plate region and the ring of cells that give rise to the trunk-tail mesoderm.DEVELOPMENTAL STAGE Expressed both maternally and zygotically. Zygotic expression increases at stage 10 (early gastrula), continues during gastrula and early neurula stages before rapidly declining during neurulation.INDUCTION By nodal/nr-1 signaling and wnt8 signaling including the downstream effectors mix-A/mix.1 and siamois acting synergistically with either lhx1/lim1 or otx2. Also by acvr1b/alk4.MISCELLANEOUS Microinjection of cer1 into blastomeres results in the formation of ectopic heads that contain cyclopic eyes as well as duplicated internal organs such as liver and heart. The heart beats at a rhythm different to that of the primary heart. Based on this phenotype the name 'cerberus' was chosen after a mythological guardian dog with multiple heads.SIMILARITY Belongs to the DAN family.SIMILARITY Contains 1 CTCK (C-terminal cystine knot-like) domain.
organism: Xenopus laevis

XCAP-D2
type: Protein
entity reference: capd2
data source: Reactome
name: Condensin complex subunit 1
xref: UnificationXref85
xref: UnificationXref86
feature: FragmentFeature15
cellular location: cytosol
comment: Reactome DB_ID: 2520855
display name: Ncapd2

Catalysis1
type: Catalysis
data source: Reactome
controlled: Cdk1 phosphorylates condensin I
control type: ACTIVATION
xref: RelationshipXref1
xref: RelationshipXref2
controller: p-T161-Cdk1:Ccnb

p-T1314,1348,1353-XCAP-D2
type: Protein
entity reference: capd2
data source: Reactome
xref: UnificationXref98
xref: UnificationXref97
feature: ModificationFeature6
feature: ModificationFeature8
feature: FragmentFeature18
feature: ModificationFeature7
cellular location: cytosol
comment: Reactome DB_ID: 2520847
display name: p-T1314,1348,1353-Ncapd2

p-xCAP-G
type: Protein
entity reference: capg
data source: Reactome
xref: UnificationXref96
xref: UnificationXref95
feature: ModificationFeature5
feature: FragmentFeature17
cellular location: cytosol
comment: Reactome DB_ID: 2520836
display name: p-Ncapg

Ccnb
type: Protein
data source: Reactome
member physical entity: G2/mitotic-specific cyclin-B2
member physical entity: G2/mitotic-specific cyclin-B1
xref: UnificationXref111
xref: UnificationXref110
cellular location: cytosol
comment: Reactome DB_ID: 2520859
comment: Converted from EntitySet in Reactome

G2/mitotic-specific cyclin-B1
type: Protein
entity reference: UniProt:P13350 ccnb1
data source: Reactome
xref: UnificationXref105
xref: UnificationXref106
feature: FragmentFeature19
cellular location: cytosol
comment: Reactome DB_ID: 2520868
display name: Ccnb1

G2/mitotic-specific cyclin-B2
type: Protein
entity reference: ccnb2
data source: Reactome
xref: UnificationXref109
xref: UnificationXref108
feature: FragmentFeature20
cellular location: cytosol
comment: Reactome DB_ID: 2520867
display name: Ccnb2

p-T161-Cdk1
type: Protein
data source: Reactome
member physical entity: p-T161-Cdk1-B
member physical entity: p-T161-Cdk1-A
xref: UnificationXref119
xref: UnificationXref118
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2520866

p-T161-Cdk1-A
type: Protein
entity reference: cdc2x1.1
data source: Reactome
xref: UnificationXref113
xref: UnificationXref114
feature: FragmentFeature21
feature: ModificationFeature9
cellular location: cytosol
comment: Reactome DB_ID: 2520863

http://identifiers.org/pubmed/18471901
type: PublicationXref
id: 18471901
author: Voets, T
author: Nilius, B
author: Talavera, K
db: Pubmed
title: Neuronal TRP channels: thermometers, pathfinders and life-savers
source: Trends Neurosci 31:287-95
year: 2008

Stoichiometry6
type: Stoichiometry
physical entity: p-S67-Ensa/p-S67-Arpp19
stoichiometric coefficient: 1.0

Stoichiometry5
type: Stoichiometry
physical entity: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
stoichiometric coefficient: 1.0

Stoichiometry4
type: Stoichiometry
physical entity: PP2A-subunit A
stoichiometric coefficient: 1.0

Stoichiometry3
type: Stoichiometry
physical entity: PP2A-catalytic subunit C
stoichiometric coefficient: 1.0

Stoichiometry2
type: Stoichiometry
physical entity: kif15-a
stoichiometric coefficient: 2.0

Stoichiometry1
type: Stoichiometry
physical entity: kif15-a
stoichiometric coefficient: 2.0

UnificationXref66
type: UnificationXref
id: 1181119
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181119

UnificationXref67
type: UnificationXref
id: REACT_111831
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111831.1

ppp2ca
type: ProteinReference
name: UniProt:Q8AVH9
xref: UnificationXref25
comment: CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
organism: Xenopus laevis

UnificationXref64
type: UnificationXref
id: REACT_111558
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111558.1

UnificationXref65
type: UnificationXref
id: Q91619
db: UniProt

UniProt:P50533 smc2
type: ProteinReference
name: cape
name: smc2l1
name: smc2
xref: UnificationXref78
comment: FUNCTION Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.SUBUNIT Forms a heterodimer with XCAP-C/SMC4. Component of the condensin complex, which contains the XCAP-E/SMC2 and XCAP-C/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: XCAP-H/BRRN1, XCAP-D2/CNAP1 and XCAP-G/CAPG.SIMILARITY Belongs to the SMC family. SMC2 subfamily.
organism: Xenopus laevis

Stoichiometry9
type: Stoichiometry
physical entity: NODAL_XENLA
stoichiometric coefficient: 1.0

p-S67-Alpha-endosulfine
type: Protein
entity reference: ensa
data source: Reactome
xref: UnificationXref13
xref: UnificationXref14
feature: ModificationFeature1
feature: FragmentFeature1
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445079
display name: p-S67-Ensa

capc
type: ProteinReference
name: smc4l1
name: smc4
name: UniProt:P50532 smc4
xref: UnificationXref72
comment: FUNCTION Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase.SUBUNIT Forms a heterodimer with XCAP-E/SMC2. Component of the condensin complex, which contains the XCAP-E/SMC2 and XCAP-C/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: XCAP-H/BRRN1, XCAP-D2/CNAP1 and XCAP-G/CAPG.SIMILARITY Belongs to the SMC family. SMC4 subfamily.
organism: Xenopus laevis

kif15-a
type: Protein
entity reference: klp2
data source: Reactome
name: KI15A_XENLA
xref: UnificationXref5
xref: UnificationXref4
cellular location: cytosol
comment: Reactome DB_ID: 984841
display name: Xklp2

UnificationXref68
type: UnificationXref
id: 1181343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181343

Stoichiometry7
type: Stoichiometry
physical entity: Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
stoichiometric coefficient: 1.0

p-S67-cAMP-regulated phosphoprotein 19-A
type: Protein
entity reference: arpp19
data source: Reactome
name: p-S67-Arpp19-a
xref: UnificationXref16
xref: UnificationXref17
feature: ModificationFeature2
feature: FragmentFeature2
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445076
display name: p-S67-Arpp19

ppp2r2d
type: ProteinReference
name: UniProt:Q7ZX64 ppp2r2d
xref: UnificationXref41
comment: FUNCTION B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors. PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restricting receptor activity. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.SUBUNIT PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when phosphorylated at 'Ser-67'), leading to inhibit PP2A activity.MISCELLANEOUS ppp2r2d is an abundant subunit in egg extracts and represents 70% or more of B55 subunits (PubMed:19793917).SIMILARITY Belongs to the phosphatase 2A regulatory subunit B family.SIMILARITY Contains 7 WD repeats.
organism: Xenopus laevis

UnificationXref69
type: UnificationXref
id: REACT_111670
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111670.1

Stoichiometry8
type: Stoichiometry
physical entity: CER1_XENLA
stoichiometric coefficient: 1.0

p-S67-Arpp19
type: Protein
data source: Reactome
member physical entity: p-S67-cAMP-regulated phosphoprotein 19-A
member physical entity: p-S67-cAMP-regulated phosphoprotein 19-B
xref: UnificationXref21
xref: UnificationXref22
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445082
comment: Converted from EntitySet in Reactome

PP2A-catalytic subunit C
type: Protein
data source: Reactome
member physical entity: Ppp2ca
member physical entity: Ppp2cb
xref: UnificationXref31
xref: UnificationXref32
cellular location: nucleoplasm
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2445063

p-S67-cAMP-regulated phosphoprotein 19-B
type: Protein
entity reference: UniProt:Q6GQG3 arpp19-b
data source: Reactome
xref: UnificationXref19
xref: UnificationXref20
feature: ModificationFeature3
feature: FragmentFeature3
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445075
display name: p-S67-Arpp19-b

Ppp2cb
type: Protein
entity reference: ppp2cb
data source: Reactome
xref: UnificationXref30
xref: UnificationXref29
feature: FragmentFeature5
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445056

Ppp2ca
type: Protein
entity reference: ppp2ca
data source: Reactome
xref: UnificationXref26
xref: UnificationXref27
feature: FragmentFeature4
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445067

UnificationXref62
type: UnificationXref
id: P70041
db: UniProt

UnificationXref63
type: UnificationXref
id: 1181319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181319

PP2A-subunit A
type: Protein
data source: Reactome
member physical entity: Ppp2r1b
member physical entity: Ppp2r1a
xref: UnificationXref40
xref: UnificationXref39
cellular location: nucleoplasm
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2445065

UnificationXref60
type: UnificationXref
id: REACT_22431
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22431.1

UnificationXref61
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

diacylglycerols
type: SmallMoleculeReference
name: diacylglycerols [ChEBI:18035]
xref: UnificationXref51

UnificationXref75
type: UnificationXref
id: Q9YHB5
db: UniProt

RelationshipXref4
type: RelationshipXref
id: 169494
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169494

UnificationXref76
type: UnificationXref
id: 2520848
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520848

RelationshipXref3
type: RelationshipXref
id: GO:0004386
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

cdc2x1.1
type: ProteinReference
name: cdk1-a
name: UniProt:P35567 cdk1-a
name: cdc2-a
xref: UnificationXref112
comment: CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.CATALYTIC ACTIVITY ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.ENZYME REGULATION Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.SUBUNIT Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with spdya.PTM Phosphorylation at Tyr-15 by wee1 and wee2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SIMILARITY Contains 1 protein kinase domain.
organism: Xenopus laevis

UnificationXref77
type: UnificationXref
id: REACT_152205
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152205.1

RelationshipXref2
type: RelationshipXref
id: 2520875
db: Reactome Database ID Release 45
relationship type: Same Catalyst Activity
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520875

UnificationXref78
type: UnificationXref
id: P50533
db: UniProt

RelationshipXref1
type: RelationshipXref
id: GO:0004693
db: GENE ONTOLOGY
relationship type: gene ontology term for cellular function

UnificationXref79
type: UnificationXref
id: 2520844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520844

UnificationXref70
type: UnificationXref
id: 1181356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1181356

UnificationXref71
type: UnificationXref
id: REACT_111035
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111035.1

UnificationXref72
type: UnificationXref
id: P50532
db: UniProt

UnificationXref73
type: UnificationXref
id: 2520839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520839

UnificationXref74
type: UnificationXref
id: REACT_151686
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151686.1

UnificationXref6
type: UnificationXref
id: 984831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=984831

UnificationXref7
type: UnificationXref
id: REACT_26722
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26722.1

UnificationXref8
type: UnificationXref
id: 984820
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=984820

UnificationXref9
type: UnificationXref
id: REACT_25157
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25157.1

UnificationXref2
type: UnificationXref
id: 8355
db: NCBI Taxonomy

UnificationXref3
type: UnificationXref
id: Q91785
db: UniProt

UnificationXref4
type: UnificationXref
id: 984841
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=984841

UnificationXref5
type: UnificationXref
id: REACT_26966
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26966.1

ppp2r1b
type: ProteinReference
name: UniProt:Q7ZYM9
xref: UnificationXref36
organism: Xenopus laevis

UnificationXref1
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

caph
type: ProteinReference
name: UniProt:O13067 ncaph
name: brrn1
name: ncaph
xref: UnificationXref81
comment: FUNCTION Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase.SUBUNIT Component of the condensin complex, which contains the XCAP-E/SMC2 and XCAP-C/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: XCAP-H/NCAPH, XCAP-D2/NCAPD2 and XCAP-G/NCAPG.PTM Phosphorylated by CDK1. Its phosphorylation, as well as that of XCAP-D2 and XCAP-G subunits, activates the condensin complex and is required for chromosome condensation.SIMILARITY Belongs to the CND2 (condensin subunit 2) family.
organism: Xenopus laevis

UnificationXref88
type: UnificationXref
id: REACT_152381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152381.1

UnificationXref89
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref86
type: UnificationXref
id: REACT_150803
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150803.1

UnificationXref87
type: UnificationXref
id: 2520852
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520852

UnificationXref84
type: UnificationXref
id: Q9YHY6
db: UniProt

UnificationXref85
type: UnificationXref
id: 2520855
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520855

UnificationXref82
type: UnificationXref
id: 2520846
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520846

UnificationXref83
type: UnificationXref
id: REACT_151734
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151734.1

UnificationXref80
type: UnificationXref
id: REACT_150766
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150766.1

UnificationXref81
type: UnificationXref
id: O13067
db: UniProt

nucleoplasm
type: CellularLocationVocabulary
xref: UnificationXref10

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref101

UnificationXref97
type: UnificationXref
id: 2520847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520847

UnificationXref98
type: UnificationXref
id: REACT_152009
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152009.1

UnificationXref99
type: UnificationXref
id: 2520849
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520849

UnificationXref93
type: UnificationXref
id: 2520850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520850

UnificationXref94
type: UnificationXref
id: REACT_152081
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152081.1

UnificationXref95
type: UnificationXref
id: 2520836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520836

UnificationXref96
type: UnificationXref
id: REACT_150584
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150584.1

UnificationXref90
type: UnificationXref
id: 113592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref91
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

UnificationXref92
type: UnificationXref
id: MOD:00047
db: MOD

Stoichiometry12
type: Stoichiometry
physical entity: XCAP-E
stoichiometric coefficient: 1.0

Stoichiometry13
type: Stoichiometry
physical entity: Condensin complex subunit 2
stoichiometric coefficient: 1.0

Stoichiometry14
type: Stoichiometry
physical entity: XCAP-D2
stoichiometric coefficient: 1.0

Stoichiometry15
type: Stoichiometry
physical entity: Adenosine 5'-triphosphate
stoichiometric coefficient: 5.0

Stoichiometry16
type: Stoichiometry
physical entity: Structural maintenance of chromosomes protein 4
stoichiometric coefficient: 1.0

Stoichiometry17
type: Stoichiometry
physical entity: p-xCAP-H
stoichiometric coefficient: 1.0

Stoichiometry18
type: Stoichiometry
physical entity: p-xCAP-G
stoichiometric coefficient: 1.0

Stoichiometry19
type: Stoichiometry
physical entity: p-T1314,1348,1353-XCAP-D2
stoichiometric coefficient: 1.0

Stoichiometry10
type: Stoichiometry
physical entity: Structural maintenance of chromosomes protein 4
stoichiometric coefficient: 1.0

Stoichiometry11
type: Stoichiometry
physical entity: Condensin complex subunit 3
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/21164014
type: PublicationXref
id: 21164014
author: Strub, JM
author: Brioudes, E
author: Van-Dorsselaer, A
author: Vigneron, S
author: Castro, A
author: Labbe, JC
author: Lorca, T
author: Gharbi-Ayachi, A
author: Burgess, Andrew
db: Pubmed
title: The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A
source: Science 330:1673-7
year: 2010

http://identifiers.org/pubmed/21164013
type: PublicationXref
id: 21164013
author: Skehel, Mark
author: Maslen, Sarah L
author: Mochida, Satoru
author: Hunt, Tim
db: Pubmed
title: Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
source: Science 330:1670-3
year: 2010

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref61

Xenopus Mcm8 mediated fork unwinding
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref132
xref: UnificationXref131
xref: http://identifiers.org/pubmed/15707891
left: Replication Fork
comment: Authored: Tye, BK, 2005-11-29 15:49:00
comment: Mcm8 is related to the Mcm2-7 helicase and is found in vertebrates but not in C. elegans or the yeasts. Studies in Xenopus egg extracts showed that Mcm8 does not associate with the soluble Mcm2-7 complex and binds chromatin upon initiation of DNA synthesis. Mcm8 depletion does not affect replication licensing or Mcm3 loading but slows down DNA synthesis and reduces chromatin recruitment of Rpa34 and DNA polymerase-alpha. Recombinant Mcm8 has ATPase and helicase activities.
right: Unwound fork

Cdk1 phosphorylates condensin I
type: BiochemicalReaction
data source: Reactome
EC number: 2.7.11.22
xref: http://identifiers.org/pubmed/9774278
xref: UnificationXref124
xref: UnificationXref123
participant stoichiometry: Stoichiometry21
participant stoichiometry: Stoichiometry15
left: Adenosine 5'-triphosphate
left: Smc2:Smc4:Ncapd2:Ncapg:Ncaph
comment: Edited: Matthews, L, 2012-10-18
comment: Reviewed: Anonymous, 2012-11-12
comment: Cdk1 (Cdc2) in complex with Ccnb (cyclin B) phosphorylates condensin I subunits Ncapd2, Ncapg and Ncaph in mitotic Xenopus egg extracts. While phosphorylation sites in Ncapg and Ncaph have not been identified, Ncapd2 is phosphorylated on threonine residues T1314, T1348 and T1353 (Kimura et al. 1998) which are conserved in human and mouse orthologs. Phosphorylation by Cdk1 enables condensin I to introduce positive supercoils into DNA and promotes chromatin condensation (Kimura et al. 1998).
comment: Edited: D'Eustachio, P, 2012-10-19
comment: Authored: Orlic-Milacic, M, 2012-10-12
right: Adenosine 5'-diphosphate
right: Smc2:Smc4:p-T1314,1348,1353-Ncapd2:Ncaph:Ncapg

Multiple Xenopus proteins are localized at replication fork
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref149
xref: http://identifiers.org/pubmed/16483939
xref: UnificationXref150
left: xCdc45
left: xMcm8
left: Replication Fork
left: xGINS complex
comment: At the beginning of this reaction, 1 molecule of 'Replication Fork', 1 molecule of 'xCdc45', 1 molecule of 'xMcm8', and 1 molecule of 'xGINS complex' are present. At the end of this reaction, 1 molecule of 'Xenopus unwinding complex at replication fork' is present. This reaction takes place in the 'nucleus'.
comment: Authored: Tye, BK, 2006-03-17 14:46:24
comment: Edited: Gopinathrao, G, 2006-03-17 14:47:28
right: Xenopus unwinding complex at replication fork

nodal
type: ProteinReference
name: UniProt:Q91619 nodal
name: nr1
xref: UnificationXref65
comment: FUNCTION Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene cascade in the left lateral plate mesoderm.SUBUNIT Homodimer; disulfide-linked (By similarity). Interacts with, and is inhibited by cer1 and gdf10/bmp3b.TISSUE SPECIFICITY In the first phase of expression, localized to the vegetal region of the blastula. During gastrulation (stage 10.5), this expression disappears and instead becomes localized to the dorsal marginal zone, with enrichment in the organizer. During the second phase of expression in neurulae and tailbud embryos, expression restarts firstly in two symmetric patches near the posterior end of the notochord, and then in a large asymmetrical domain in the left lateral plate mesoderm.DEVELOPMENTAL STAGE Has two phases of temporal expression during embryogenesis; first expressed at late blastula (stage 9) with expression peaking at early gastrula. Expression then disappears before restarting in a second phase in late neurulae (stage 17).INDUCTION By dorsal mesoderm-inducing signals including smad2-smad4, activin and other nodal-related proteins including nodal2/nr-2 and nodal4/nr-4. Shows autoinduction by nodal/nr-1. Induced by vegt, acting in an autoregulatory loop. Beta-catenin potentiates the response to activin. Not induced by wnt8 alone, but wnt8 potentiates the response to activin. Suppressed by ventral inducers such as bmp4.SIMILARITY Belongs to the TGF-beta family.
organism: Xenopus laevis

p-S67-Ensa/p-S67-Arpp19 binds PP2A-Ppp2r2d
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/21164014
xref: UnificationXref48
xref: http://identifiers.org/pubmed/21164013
xref: UnificationXref49
left: Serine/threonine-protein phosphatase 2A complex with regulatory subunit Ppp2r2d
left: p-S67-Ensa/p-S67-Arpp19
comment: Authored: Orlic-Milacic, M, 2012-09-04
comment: Reviewed: Burgess, A, 2012-09-28
comment: Recombinant Xenopus Ensa and Arpp19 are phosphorylated by recombinant Xenopus Mastl on serine residue S67. Once phosphorylated, Ensa and Arpp19 bind and inhibit the phosphatase activity of PP2A complexed with the regulatory subunit Ppp2r2d (B55-delta) (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).
comment: Edited: Gillespie, ME, 2012-09-14
comment: Reviewed: Mochida, Satoru, 2012-09-26
right: p-S67-Ensa/p-S67-Arpp19:PP2A-Ppp2r2d

Xenopus kinesin-12 is a dimer
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/9813089
xref: UnificationXref8
xref: UnificationXref9
participant stoichiometry: Stoichiometry1
left: kif15-a
comment: Reviewed: Ouwehand, WH, 2010-11-12
comment: Authored: Akkerman, JW, 2010-10-29
comment: The kinesin-12 family member Xklp2 is a plus-end-directed dimeric kinesin.
comment: Edited: Jupe, S, 2010-11-15
right: Xklp2 dimer

Cerberus Binds Nodal
type: BiochemicalReaction
data source: Reactome
xref: http://identifiers.org/pubmed/10067895
xref: UnificationXref71
xref: UnificationXref70
left: CER1_XENLA
left: NODAL_XENLA
comment: Cerberus binds Xnr-1, the Xenopus Nodal homolog, and negatively regulates Xnr-1 signaling (Piccolo et al. 1999).
comment: Reviewed: Peng, C, 2011-08-24
comment: Edited: May, B, 2011-01-27
comment: Authored: May, B, 2011-01-27
right: Cerberus:Nodal

Activation of TRPC channels by Netrin-1
type: BiochemicalReaction
data source: Reactome
xref: UnificationXref60
xref: http://identifiers.org/pubmed/18471901
xref: http://identifiers.org/pubmed/12857742
xref: UnificationXref59
left: diacylglycerols
left: TRPC1_Xenopus
comment: Reviewed: Cooper, HM, 2010-02-16
comment: Edited: Garapati, P V, 2010-04-23
comment: Netrin-1, through its activation of DCC, triggers TRPC channel mediating the Ca+2 influx that is required for the growth cone turning. The effect of netrin-1 on TRP currents in the neurons is studied in Xenopus. In cultured Xenopus spinal neurons, Netrin-1 evoked Ca+2 influx and a depolarizing, TRPC-like current in both soma and growth cones. Inhibition of the Xenopus homologue of mammalian TRPC1 (XTRPC1) prevented Ca+2 influx, TRPC-like current activation and the chemotropic turning of the growth cone in response to a gradient of Netrin-1. Netrin-1 receptor signalling to TRPC channels is mediated via hydrolysis of PIP2 by PLCgamma which then activates TRPC channel activity through IP3 and DAG.
comment: Authored: Garapati, P V, 2010-04-23
right: diacylglycerols
right: Activated xtrpc1

SequenceSite8
type: SequenceSite
position status: EQUAL
sequence position: 1

klp2
type: ProteinReference
name: kif15-a
name: UniProt:Q91785 kif15-a
xref: UnificationXref3
comment: FUNCTION Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Required for centrosome separation and maintenance of spindle bipolarity during mitosis.SUBUNIT Homodimer. Dimerization is required for targeting to microtubule minus ends. Found in a complex with tpx2 and microtubules. Its association with microtubules and targeting to microtubule minus ends requires tpx2.TISSUE SPECIFICITY Strongly expressed in testis and weakly in lung (at protein level).DEVELOPMENTAL STAGE Expressed maternally in oocytes and eggs (at protein level).SIMILARITY Belongs to the kinesin-like protein family. KLP2 subfamily.SIMILARITY Contains 1 kinesin-motor domain.
organism: Xenopus laevis

SequenceSite9
type: SequenceSite
position status: EQUAL
sequence position: 117

UnificationXref109
type: UnificationXref
id: REACT_150623
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150623.1

SequenceSite6
type: SequenceSite
position status: EQUAL
sequence position: 117

gins2
type: ProteinReference
name: psf2
name: UniProt:Q7ZT46 gins2
xref: UnificationXref136
comment: FUNCTION The GINS complex plays an essential role in the initiation of DNA replication.SUBUNIT Component of the GINS complex which is a heterotetramer of gins1/psf1, gins2/psf2, gins3/psf3 and gins4/sld5.SIMILARITY Belongs to the GINS2/PSF2 family.
organism: Xenopus laevis

SequenceSite7
type: SequenceSite
position status: EQUAL
sequence position: 67

Stoichiometry30
type: Stoichiometry
physical entity: Replication Fork
stoichiometric coefficient: 1.0

SequenceSite4
type: SequenceSite
position status: EQUAL
sequence position: 67

Stoichiometry31
type: Stoichiometry
physical entity: xMcm8
stoichiometric coefficient: 1.0

SequenceSite5
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite2
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite3
type: SequenceSite
position status: EQUAL
sequence position: 125

SequenceSite1
type: SequenceSite
position status: EQUAL
sequence position: 67

UnificationXref100
type: UnificationXref
id: REACT_152425
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152425.1

UnificationXref105
type: UnificationXref
id: 2520868
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520868

UnificationXref106
type: UnificationXref
id: REACT_152471
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152471.1

UnificationXref107
type: UnificationXref
id: P13351
db: UniProt

http://identifiers.org/pubmed/9774278
type: PublicationXref
id: 9774278
author: Kobayashi, R
author: Hirano, T
author: Hirano, M
author: Kimura, K
db: Pubmed
title: Phosphorylation and activation of 13S condensin by Cdc2 in vitro
source: Science 282:487-90
year: 1998

UnificationXref108
type: UnificationXref
id: 2520867
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520867

UnificationXref101
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ppp2r1a
type: ProteinReference
name: UniProt:Q7ZWS7
xref: UnificationXref33
organism: Xenopus laevis

UnificationXref102
type: UnificationXref
id: 29370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref103
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref104
type: UnificationXref
id: P13350
db: UniProt

Stoichiometry29
type: Stoichiometry
physical entity: xCdc45
stoichiometric coefficient: 1.0

Stoichiometry27
type: Stoichiometry
physical entity: xPSF2p
stoichiometric coefficient: 1.0

Stoichiometry28
type: Stoichiometry
physical entity: xGINS complex
stoichiometric coefficient: 1.0

Stoichiometry25
type: Stoichiometry
physical entity: xPSF3p
stoichiometric coefficient: 1.0

Stoichiometry26
type: Stoichiometry
physical entity: xSLD5P
stoichiometric coefficient: 1.0

Stoichiometry23
type: Stoichiometry
physical entity: p-T161-Cdk1
stoichiometric coefficient: 1.0

Stoichiometry24
type: Stoichiometry
physical entity: xPSF1p
stoichiometric coefficient: 1.0

Stoichiometry21
type: Stoichiometry
physical entity: Adenosine 5'-diphosphate
stoichiometric coefficient: 5.0

Stoichiometry22
type: Stoichiometry
physical entity: Ccnb
stoichiometric coefficient: 1.0

Stoichiometry20
type: Stoichiometry
physical entity: XCAP-E
stoichiometric coefficient: 1.0

cdk1-b
type: ProteinReference
name: cdc2x1.2
name: UniProt:P24033 cdk1-b
name: cdc2
xref: UnificationXref115
comment: CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein.CATALYTIC ACTIVITY ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.ENZYME REGULATION Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.SUBUNIT Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with spdya.PTM Phosphorylation at Tyr-15 by wee1 and wee2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SIMILARITY Contains 1 protein kinase domain.
organism: Xenopus laevis

UnificationXref117
type: UnificationXref
id: REACT_150661
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150661.1

UnificationXref116
type: UnificationXref
id: 2520864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520864

UniProt:Q6GQG3 arpp19-b
type: ProteinReference
name: arpp19-b
xref: UnificationXref18
comment: SIMILARITY Belongs to the endosulfine family.
organism: Xenopus laevis

capg
type: ProteinReference
name: ncapg
name: UniProt:Q9YHB5 ncapg
xref: UnificationXref75
comment: FUNCTION Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase.SUBUNIT Component of the condensin complex, which contains the XCAP-E/SMC2 and XCAP-C/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: XCAP-H/NCAPH, XCAP-D2/NCAPD2 and XCAP-G/NCAPG.PTM Phosphorylated by cdk1. Its phosphorylation, as well as that of XCAP-D2 and XCAP-H subunits, activates the condensin complex and is required for chromosome condensation.SIMILARITY Belongs to the CND3 (condensin subunit 3) family.SIMILARITY Contains 10 HEAT repeats.
organism: Xenopus laevis

UnificationXref119
type: UnificationXref
id: REACT_151094
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151094.1

UnificationXref118
type: UnificationXref
id: 2520866
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520866

UnificationXref113
type: UnificationXref
id: 2520863
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520863

UnificationXref112
type: UnificationXref
id: P35567
db: UniProt

UnificationXref115
type: UnificationXref
id: P24033
db: UniProt

UnificationXref114
type: UnificationXref
id: REACT_151951
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151951.1

UnificationXref111
type: UnificationXref
id: REACT_150805
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150805.1

UnificationXref110
type: UnificationXref
id: 2520859
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520859

SequenceSite11
type: SequenceSite
position status: EQUAL
sequence position: 309

SequenceSite12
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite10
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref129
type: UnificationXref
id: 169493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169493

UnificationXref128
type: UnificationXref
id: REACT_7610
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7610.1

UnificationXref127
type: UnificationXref
id: 169509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169509

UnificationXref126
type: UnificationXref
id: REACT_7812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7812.1

UnificationXref125
type: UnificationXref
id: 169515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169515

UnificationXref124
type: UnificationXref
id: REACT_150138
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150138.2

UnificationXref123
type: UnificationXref
id: 2520871
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520871

SequenceSite14
type: SequenceSite
position status: EQUAL
sequence position: 2

UnificationXref122
type: UnificationXref
id: MI:0355
db: MI

SequenceSite13
type: SequenceSite
position status: EQUAL
sequence position: 309

UnificationXref121
type: UnificationXref
id: REACT_151167
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151167.1

SequenceSite16
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref120
type: UnificationXref
id: 2520869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2520869

SequenceSite15
type: SequenceSite
position status: EQUAL
sequence position: 1589

SequenceSite18
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite17
type: SequenceSite
position status: EQUAL
sequence position: 589

SequenceSite19
type: SequenceSite
position status: EQUAL
sequence position: 447

SequenceSite20
type: SequenceSite
position status: EQUAL
sequence position: 21

SequenceSite21
type: SequenceSite
position status: EQUAL
sequence position: 270

SequenceSite22
type: SequenceSite
position status: EQUAL
sequence position: 282

SequenceSite23
type: SequenceSite
position status: EQUAL
sequence position: 406

UnificationXref135
type: UnificationXref
id: REACT_7229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7229.1

UnificationXref134
type: UnificationXref
id: 176954
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176954

UnificationXref137
type: UnificationXref
id: 176946
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176946

UnificationXref136
type: UnificationXref
id: Q7ZT46
db: UniProt

UnificationXref139
type: UnificationXref
id: 176957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176957

UnificationXref138
type: UnificationXref
id: REACT_7280
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7280.1

Adenosine 5'-triphosphate
type: SmallMoleculeReference
name: ATP
name: ATP [ChEBI:15422]
xref: UnificationXref89

ppp2cb
type: ProteinReference
name: UniProt:Q92140
name: Ppp2cb
xref: UnificationXref28
comment: CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
organism: Xenopus laevis

UnificationXref131
type: UnificationXref
id: 169440
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=169440

UnificationXref130
type: UnificationXref
id: REACT_7799
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7799.1

UnificationXref133
type: UnificationXref
id: Q9YHZ6
db: UniProt

UnificationXref132
type: UnificationXref
id: REACT_6758
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6758.1

http://identifiers.org/pubmed/10067895
type: PublicationXref
id: 10067895
author: De Robertis, EM
author: Piccolo, S
author: Agius, E
author: Leyns, L
author: Grunz, H
author: Bouwmeester, T
author: Bhattacharyya, S
db: Pubmed
title: The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
source: Nature 397:707-10
year: 1999

UnificationXref148
type: UnificationXref
id: REACT_7728
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7728.1

UnificationXref147
type: UnificationXref
id: 176972
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176972

UnificationXref146
type: UnificationXref
id: REACT_7299
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7299.1

UnificationXref145
type: UnificationXref
id: 176953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176953

UnificationXref149
type: UnificationXref
id: 176971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176971

UnificationXref140
type: UnificationXref
id: REACT_7031
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7031.1

UnificationXref144
type: UnificationXref
id: REACT_7713
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7713.1

UnificationXref143
type: UnificationXref
id: 176950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176950

UnificationXref142
type: UnificationXref
id: REACT_7377
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7377.1

UnificationXref141
type: UnificationXref
id: 176951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=176951

SequenceSite48
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite49
type: SequenceSite
position status: EQUAL
sequence position: 302

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref103
xref: UnificationXref102
cellular location: cytosol
comment: Reactome DB_ID: 29370
display name: ADP

SequenceSite46
type: SequenceSite
position status: EQUAL
sequence position: 392

SequenceSite47
type: SequenceSite
position status: EQUAL
sequence position: 161

diacylglycerols
type: SmallMolecule
entity reference: diacylglycerols
data source: Reactome
name: DAGs
xref: UnificationXref53
xref: UnificationXref52
cellular location: plasma membrane
comment: Reactome DB_ID: 112275
display name: DAG

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref91
xref: UnificationXref90
cellular location: cytosol
comment: Reactome DB_ID: 113592
display name: ATP

UnificationXref150
type: UnificationXref
id: REACT_6943
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6943.3

arpp19
type: ProteinReference
name: arpp19-a
name: UniProt:Q6DEB4 arpp19-a
xref: UnificationXref15
comment: FUNCTION Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.SUBUNIT Interacts (when phosphorylated at Ser-67) with ppp2r2d.PTM Phosphorylation at Ser-67 by gwl during mitosis is essential for interaction with ppp2r2d (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA.SIMILARITY Belongs to the endosulfine family.
organism: Xenopus laevis

Reactome
type: Provenance
comment: http://www.reactome.org

SequenceSite52
type: SequenceSite
position status: EQUAL
sequence position: 302

SequenceSite51
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite50
type: SequenceSite
position status: EQUAL
sequence position: 161

SequenceSite28
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite29
type: SequenceSite
position status: EQUAL
sequence position: 1203

SequenceSite26
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite27
type: SequenceSite
position status: EQUAL
sequence position: 1034

SequenceSite24
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite25
type: SequenceSite
position status: EQUAL
sequence position: 1290

SequenceSite34
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite33
type: SequenceSite
position status: EQUAL
sequence position: 1364

SequenceSite32
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite31
type: SequenceSite
position status: EQUAL
sequence position: 699

SequenceSite30
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite39
type: SequenceSite
position status: EQUAL
sequence position: 1348

O-phospho-L-threonine
type: SequenceModificationVocabulary
xref: UnificationXref92

SequenceSite35
type: SequenceSite
position status: EQUAL
sequence position: 699

O-phospho-L-serine
type: SequenceModificationVocabulary
xref: UnificationXref12

SequenceSite36
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite37
type: SequenceSite
position status: EQUAL
sequence position: 1034

SequenceSite38
type: SequenceSite
position status: EQUAL
sequence position: 1314

trpc1
type: ProteinReference
name: trp1
name: UniProt:Q9PRI8
xref: UnificationXref54
organism: Xenopus laevis

SequenceSite43
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite42
type: SequenceSite
position status: EQUAL
sequence position: 1364

SequenceSite45
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite44
type: SequenceSite
position status: EQUAL
sequence position: 397

SequenceSite41
type: SequenceSite
position status: EQUAL
sequence position: 1

SequenceSite40
type: SequenceSite
position status: EQUAL
sequence position: 1353

UnificationXref42
type: UnificationXref
id: 2445064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445064

UnificationXref43
type: UnificationXref
id: REACT_151093
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151093.1

UnificationXref44
type: UnificationXref
id: 2445055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445055

UnificationXref45
type: UnificationXref
id: REACT_151438
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151438.1

UnificationXref46
type: UnificationXref
id: 2445084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445084

UnificationXref47
type: UnificationXref
id: REACT_150684
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150684.1

capd2
type: ProteinReference
name: ncapd2
name: cnap1
name: eg7
name: UniProt:Q9YHY6 ncapd2
xref: UnificationXref84
comment: FUNCTION Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.SUBUNIT Component of the condensin complex, which contains the XCAP-E/SMC2 and XCAP-C/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: XCAP-H/NCAPH, XCAP-D2/NCAPD2 and XCAP-G/NCAPG.PTM Phosphorylated by CDK1. Its phosphorylation, as well as that of XCAP-H and XCAP-G subunits, activates the condensin complex and is required for chromosome condensation.SIMILARITY Belongs to the CND1 (condensin subunit 1) family.
organism: Xenopus laevis

UnificationXref48
type: UnificationXref
id: 2445086
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445086

UnificationXref49
type: UnificationXref
id: REACT_150280
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150280.2

UnificationXref40
type: UnificationXref
id: REACT_151363
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151363.1

UnificationXref41
type: UnificationXref
id: Q7ZX64
db: UniProt

ensa
type: ProteinReference
name: UniProt:Q7ZXH9 ensa
xref: UnificationXref11
comment: FUNCTION Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.SUBUNIT Interacts (when phosphorylated at Ser-67) with ppp2r2d.PTM Phosphorylation at Ser-67 by gwl during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA.SIMILARITY Belongs to the endosulfine family.
organism: Xenopus laevis

UnificationXref55
type: UnificationXref
id: 622401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=622401

UnificationXref56
type: UnificationXref
id: REACT_22801
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22801.1

UnificationXref53
type: UnificationXref
id: REACT_12312
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_12312.3

UnificationXref54
type: UnificationXref
id: Q9PRI8
db: UniProt

UnificationXref59
type: UnificationXref
id: 622403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=622403

cdc45
type: ProteinReference
name: cdc45l
name: UniProt:Q9YHZ6 cdc45
xref: UnificationXref133
comment: FUNCTION Required for initiation of chromosomal DNA replication. Binds to chromatin in a mutually dependent manner with the GINS DNA replication complex.SUBUNIT Interacts with topbp1.SIMILARITY Belongs to the CDC45 family.
organism: Xenopus laevis

UnificationXref57
type: UnificationXref
id: 622399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=622399

UnificationXref58
type: UnificationXref
id: REACT_23176
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23176.1

UnificationXref51
type: UnificationXref
id: CHEBI:18035
db: ChEBI

UnificationXref52
type: UnificationXref
id: 112275
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=112275

UnificationXref50
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref29
type: UnificationXref
id: 2445056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445056

UnificationXref28
type: UnificationXref
id: Q92140
db: UniProt

UnificationXref24
type: UnificationXref
id: REACT_152023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152023.1

UnificationXref25
type: UnificationXref
id: Q8AVH9
db: UniProt

UnificationXref26
type: UnificationXref
id: 2445067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445067

UnificationXref27
type: UnificationXref
id: REACT_151443
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151443.1

Xenopus laevis
type: BioSource
xref: UnificationXref2

UnificationXref20
type: UnificationXref
id: REACT_150973
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150973.1

UnificationXref21
type: UnificationXref
id: 2445082
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445082

UnificationXref22
type: UnificationXref
id: REACT_152433
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152433.1

UnificationXref23
type: UnificationXref
id: 2445081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445081

UnificationXref39
type: UnificationXref
id: 2445065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445065

UnificationXref37
type: UnificationXref
id: 2445062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445062

UnificationXref38
type: UnificationXref
id: REACT_151479
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151479.1

UnificationXref35
type: UnificationXref
id: REACT_150779
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150779.1

UnificationXref36
type: UnificationXref
id: Q7ZYM9
db: UniProt

UnificationXref33
type: UnificationXref
id: Q7ZWS7
db: UniProt

UnificationXref34
type: UnificationXref
id: 2445058
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445058

http://identifiers.org/pubmed/15707891
type: PublicationXref
id: 15707891
author: Danis, E
author: Mechali, M
author: Cuvier, O
author: Maiorano, D
db: Pubmed
title: MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
source: Cell 120:315-28
year: 2005

UnificationXref31
type: UnificationXref
id: 2445063
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445063

UnificationXref32
type: UnificationXref
id: REACT_150825
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150825.1

UnificationXref30
type: UnificationXref
id: REACT_151542
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151542.1

UnificationXref19
type: UnificationXref
id: 2445075
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445075

gene ontology term for cellular function
type: RelationshipTypeVocabulary
xref: UnificationXref122

UnificationXref17
type: UnificationXref
id: REACT_151023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151023.1

UnificationXref18
type: UnificationXref
id: Q6GQG3
db: UniProt

http://identifiers.org/pubmed/16483939
type: PublicationXref
id: 16483939
author: Pacek, M
author: Kubota, Y
author: Takisawa, H
author: Tutter, AV
author: Walter, JC
db: Pubmed
title: Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication
source: Mol Cell 21:581-7
year: 2006

UnificationXref12
type: UnificationXref
id: MOD:00046
db: MOD

UnificationXref11
type: UnificationXref
id: Q7ZXH9
db: UniProt

UnificationXref10
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

UnificationXref16
type: UnificationXref
id: 2445076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445076

UnificationXref15
type: UnificationXref
id: Q6DEB4
db: UniProt

UnificationXref14
type: UnificationXref
id: REACT_152508
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152508.1

UnificationXref13
type: UnificationXref
id: 2445079
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2445079

xSLD5P
type: PhysicalEntity
data source: Reactome
xref: UnificationXref142
xref: UnificationXref141
cellular location: nucleoplasm
comment: Reactome DB_ID: 176951

xPSF2p
type: PhysicalEntity
data source: Reactome
xref: UnificationXref143
xref: UnificationXref144
cellular location: nucleoplasm
comment: Reactome DB_ID: 176950

xMcm8
type: PhysicalEntity
data source: Reactome
xref: UnificationXref129
xref: UnificationXref130
cellular location: nucleoplasm
comment: Reactome DB_ID: 169493

xPSF3p
type: PhysicalEntity
data source: Reactome
xref: UnificationXref140
xref: UnificationXref139
cellular location: nucleoplasm
comment: Reactome DB_ID: 176957

Replication Fork
type: PhysicalEntity
data source: Reactome
xref: UnificationXref125
xref: UnificationXref126
cellular location: nucleoplasm
comment: Reactome DB_ID: 169515

Unwound fork
type: PhysicalEntity
data source: Reactome
xref: UnificationXref127
xref: UnificationXref128
cellular location: nucleoplasm
comment: Reactome DB_ID: 169509

p-S67-Ensa/p-S67-Arpp19
type: PhysicalEntity
data source: Reactome
xref: UnificationXref24
xref: UnificationXref23
cellular location: nucleoplasm
comment: Reactome DB_ID: 2445081
comment: Converted from EntitySet in Reactome
member physical entity: p-S67-Alpha-endosulfine
member physical entity: p-S67-Arpp19

Same Catalyst Activity
type: RelationshipTypeVocabulary