UniProt:Q99TF4
type: ProteinReference
xref: UnificationXref811
organism: BioSource1

RelationshipXref265
type: RelationshipXref
id: GO:0006548
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref264
type: RelationshipXref
id: 4229944
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229944

RelationshipXref263
type: RelationshipXref
id: GO:0016812
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref262
type: RelationshipXref
id: 4229939
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229939

RelationshipXref269
type: RelationshipXref
id: 4229982
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229982

http://identifiers.org/pubmed/19837038
type: PublicationXref
id: 19837038
author: Ashley, James
author: Ataman, Bulent
author: Budnik, Vivian
author: Ramachandran, Preethi
author: Gherbesi, Norberto
author: Barria, Romina
author: Korkut, Ceren
db: Pubmed
title: Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless
source: Cell 139:393-404
year: 2009

RelationshipXref268
type: RelationshipXref
id: GO:0004361
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref267
type: RelationshipXref
id: 4229951
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229951

RelationshipXref266
type: RelationshipXref
id: GO:0047536
db: GENE ONTOLOGY
relationship type: MI:0355

Triacylglycerol biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction27
evidence: Evidence45
xref: UnificationXref374
xref: UnificationXref373
xref: RelationshipXref50
pathway order: PathwayStep41
display name: Triglyceride Biosynthesis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref271
type: RelationshipXref
id: GO:0004838
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref272
type: RelationshipXref
id: 4229989
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229989

RelationshipXref270
type: RelationshipXref
id: GO:0006554
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref274
type: RelationshipXref
id: GO:0003842
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref273
type: RelationshipXref
id: GO:0006559
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref276
type: RelationshipXref
id: GO:0006562
db: GENE ONTOLOGY
relationship type: MI:0359

Prostaglandin F2a
type: SmallMoleculeReference
name: Prostaglandin F2alpha
name: Enzaprost
name: Prostin F 2 alpha
name: Prostaglandin F2
name: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
name: PGF2a
name: Prostarmon F
name: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-,(5Z,9a,11a,13E,15S)-
name: Prostaglandin F2alpha [ChEBI:8516]
name: U 14583
name: 9a,11a-PGF2
name: Dinoprost
name: Protamodin
name: 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-
name: Panacelan
name: Cyclosin
name: (+)-Prostaglandin F2a
name: Enzaprost F
name: 7-[3, 5-dihydroxy-2-(3-hydroxy-1-octenyl) cyclopentyl]-5-heptenoic acid
name: Amoglandin
xref: UnificationXref550

RelationshipXref275
type: RelationshipXref
id: 4229890
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229890

RelationshipXref278
type: RelationshipXref
id: 4229995
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229995

Prostaglandin E2 [ChEBI:8512]
type: SmallMoleculeReference
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
name: Prostaglandin E2
name: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
xref: UnificationXref547

RelationshipXref277
type: RelationshipXref
id: GO:0016831
db: GENE ONTOLOGY
relationship type: MI:0355

(5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate
type: SmallMoleculeReference
name: (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate [ChEBI:244]
xref: UnificationXref565

RelationshipXref279
type: RelationshipXref
id: GO:0016212
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/9809442
type: PublicationXref
id: 9809442
author: Marin-Garcia, J
author: Ananthakrishnan, R
author: Goldenthal, MJ
db: Pubmed
title: Cloning and molecular analysis of the human citrate synthase gene
source: Genome 41:733-738
year: 1998

RelationshipXref280
type: RelationshipXref
id: 4231025
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231025

RelationshipXref281
type: RelationshipXref
id: GO:0006569
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref282
type: RelationshipXref
id: GO:0004087
db: GENE ONTOLOGY
relationship type: MI:0355

(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
type: SmallMoleculeReference
name: (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
name: (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate [ChEBI:147]
xref: UnificationXref619

RelationshipXref283
type: RelationshipXref
id: 4229841
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229841

RelationshipXref247
type: RelationshipXref
id: GO:0032324
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref246
type: RelationshipXref
id: 4231047
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231047

RelationshipXref245
type: RelationshipXref
id: GO:0016740
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref244
type: RelationshipXref
id: 4231064
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231064

RelationshipXref243
type: RelationshipXref
id: GO:0030366
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref242
type: RelationshipXref
id: 4231054
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231054

RelationshipXref241
type: RelationshipXref
id: GO:0070283
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref240
type: RelationshipXref
id: GO:0046655
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:Q99TD1
type: ProteinReference
xref: UnificationXref2087
organism: BioSource1

RelationshipXref249
type: RelationshipXref
id: GO:0006766
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref248
type: RelationshipXref
id: GO:0006767
db: GENE ONTOLOGY
relationship type: MI:0359

Citric acid cycle (TCA cycle)
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction56
pathway component: BiochemicalReaction58
pathway component: BiochemicalReaction57
pathway component: BiochemicalReaction60
pathway component: BiochemicalReaction59
evidence: Evidence114
xref: RelationshipXref127
xref: UnificationXref857
xref: UnificationXref858
pathway order: PathwayStep107
pathway order: PathwayStep106
pathway order: PathwayStep109
pathway order: PathwayStep108
pathway order: PathwayStep110
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref250
type: RelationshipXref
id: GO:0004587
db: GENE ONTOLOGY
relationship type: MI:0355

abacavir 5'-carboxylic acid
type: SmallMoleculeReference
name: abacavir 5'-carboxylic acid [ChEBI:64192]
xref: UnificationXref2215

http://identifiers.org/pubmed/12616642
type: PublicationXref
id: 12616642
author: Vessey, DA
author: Kelley, M
author: Lau, E
author: Warren, RS
db: Pubmed
title: Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria
source: J Biochem Mol Toxicol 17:1-6
year: 2003

RelationshipXref256
type: RelationshipXref
id: GO:0003826
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref255
type: RelationshipXref
id: GO:0008652
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref258
type: RelationshipXref
id: GO:0009083
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref257
type: RelationshipXref
id: 4229928
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229928

RelationshipXref252
type: RelationshipXref
id: GO:0004617
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref251
type: RelationshipXref
id: 4229883
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229883

RelationshipXref254
type: RelationshipXref
id: GO:0006564
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref253
type: RelationshipXref
id: 4231082
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231082

RelationshipXref259
type: RelationshipXref
id: GO:0004397
db: GENE ONTOLOGY
relationship type: MI:0355

ChEBI:29265 Asn-tRNA(Asn)
type: SmallMoleculeReference
name: Asn-tRNA(Asn)
xref: UnificationXref2344

6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol [ChEBI:64181]
type: SmallMoleculeReference
name: 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol
xref: UnificationXref702

2-methoxy-6-decaprenyl-1,4-benzoquinol [ChEBI:64180]
type: SmallMoleculeReference
name: 2-methoxy-6-decaprenyl-1,4-benzoquinol
xref: UnificationXref694

RelationshipXref260
type: RelationshipXref
id: 4229933
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229933

RelationshipXref261
type: RelationshipXref
id: GO:0016153
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11158296
type: PublicationXref
id: 11158296
author: Pelzer, W
author: Kmita, H
author: Diekert, K
author: Bedekovics, T
author: Lill, R
author: Prohl, C
author: Kispal, G
db: Pubmed
title: The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix
source: Mol Cell Biol 21:1089-97
year: 2001

RelationshipXref228
type: RelationshipXref
id: GO:0006769
db: GENE ONTOLOGY
relationship type: MI:0359

ChEBI:37154 fumarate(1-)
type: SmallMoleculeReference
name: fumarate(1-)
xref: UnificationXref962

RelationshipXref229
type: RelationshipXref
id: GO:0019674
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref226
type: RelationshipXref
id: GO:0004516
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref227
type: RelationshipXref
id: 4230541
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230541

RelationshipXref220
type: RelationshipXref
id: 4230522
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230522

RelationshipXref221
type: RelationshipXref
id: GO:0004140
db: GENE ONTOLOGY
relationship type: MI:0355

Thymine
type: SmallMoleculeReference
name: Thymine [ChEBI:17821]
xref: UnificationXref1199

RelationshipXref224
type: RelationshipXref
id: GO:0015939
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref225
type: RelationshipXref
id: GO:0006768
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref222
type: RelationshipXref
id: 4230524
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230524

RelationshipXref223
type: RelationshipXref
id: GO:0009108
db: GENE ONTOLOGY
relationship type: MI:0359

carbovir diphosphate [ChEBI:64172]
type: SmallMoleculeReference
name: carbovir diphosphate
xref: UnificationXref2223

RelationshipXref237
type: RelationshipXref
id: 4230591
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230591

RelationshipXref238
type: RelationshipXref
id: GO:0004486
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref239
type: RelationshipXref
id: 4230589
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230589

RelationshipXref230
type: RelationshipXref
id: GO:0033560
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref231
type: RelationshipXref
id: 4230553
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230553

RelationshipXref232
type: RelationshipXref
id: GO:0004326
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref233
type: RelationshipXref
id: 4230547
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230547

RelationshipXref234
type: RelationshipXref
id: GO:0004329
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref235
type: RelationshipXref
id: 4230595
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230595

RelationshipXref236
type: RelationshipXref
id: GO:0004477
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/10706561
type: PublicationXref
id: 10706561
author: Akagi, R
author: Doss, MO
author: Shimizu, R
author: Furuyama, K
author: Sassa, S
db: Pubmed
title: Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria
source: Hepatology 31:704-8
year: 2000

PublicationXref8
type: PublicationXref
author: Marder, V
author: George, J
author: Colman, R
author: Goldhaber, S
author: Clowes, A
title: Hemostasis and Thrombosis: Basic Principles and Clinical Practice
year: 2005

PublicationXref9
type: PublicationXref
author: Machin, S
author: Allford, S
title: Haemostasis
source: Surgery (Oxford) 22:200a - 200d
year: 2004

RelationshipXref208
type: RelationshipXref
id: 4231221
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231221

RelationshipXref209
type: RelationshipXref
id: GO:0036222
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref206
type: RelationshipXref
id: 4231215
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231215

RelationshipXref207
type: RelationshipXref
id: GO:0035870
db: GENE ONTOLOGY
relationship type: MI:0355

PublicationXref6
type: PublicationXref
author: Page, C
author: Vermylen, J
author: Fuster, V
author: Gresele, P
title: Platelets in thrombotic and non-thrombotic disorders.
source: 435-437
year: 2002

RelationshipXref204
type: RelationshipXref
id: GO:0015949
db: GENE ONTOLOGY
relationship type: MI:0359

SLC-mediated transmembrane transport
type: Pathway
data source: Reactome
pathway component: REACT 85122.9
pathway component: Transport of vitamins, nucleosides, and related molecules
pathway component: REACT 102895.9
evidence: Evidence395
xref: UnificationXref2877
xref: UnificationXref2876
xref: RelationshipXref465
pathway order: PathwayStep362
pathway order: PathwayStep385
pathway order: PathwayStep379
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref205
type: RelationshipXref
id: GO:0036220
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref202
type: RelationshipXref
id: 4230985
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230985

RelationshipXref203
type: RelationshipXref
id: 4230990
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230990

RelationshipXref200
type: RelationshipXref
id: 4230150
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230150

RelationshipXref201
type: RelationshipXref
id: GO:0004550
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref219
type: RelationshipXref
id: GO:0004595
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref215
type: RelationshipXref
id: 4230535
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230535

RelationshipXref216
type: RelationshipXref
id: 4230563
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230563

RelationshipXref217
type: RelationshipXref
id: GO:0004633
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref218
type: RelationshipXref
id: 4230530
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230530

RelationshipXref211
type: RelationshipXref
id: GO:0055086
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref212
type: RelationshipXref
id: GO:0008523
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref213
type: RelationshipXref
id: 4230568
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230568

RelationshipXref214
type: RelationshipXref
id: GO:0004594
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref210
type: RelationshipXref
id: 4231218
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231218

D-Glycerate 2-phosphate
type: SmallMoleculeReference
name: 2-Phospho-D-glycerate [ChEBI:17835]
name: 2-Phospho-D-glycerate
xref: UnificationXref130

'Ac-CoA [mitochondrial matrix]' positively regulates 'Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate'
type: Control
data source: Reactome
xref: UnificationXref198
controlled: Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
control type: ACTIVATION
controller: Acetyl coenzyme A

'IMP [cytosol]' positively regulates 'Formation of phosphoribosyl pyrophosphate amidotransferase tetramer'
type: Control
data source: Reactome
xref: UnificationXref892
controlled: BiochemicalReaction63
control type: ACTIVATION
controller: Inosine 5'-phosphate

'Ac-CoA [cytosol]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Reactome
xref: UnificationXref165
controlled: phosphoenolpyruvate + ADP => pyruvate + ATP
control type: INHIBITION
controller: Acetyl coenzyme A

'PRPP [cytosol]' positively regulates 'Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer'
type: Control
data source: Reactome
xref: UnificationXref903
controlled: BiochemicalReaction64
control type: ACTIVATION
controller: 5-Phosphoribosyl 1-pyrophosphate

Control16
type: Control
data source: Reactome
xref: UnificationXref915
controlled: BiochemicalReaction65
control type: INHIBITION
display name: 'Formation of phosphoribosyl pyrophosphate amidotransferase tetramer' negatively regulates '5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate'

'AMP [cytosol]' positively regulates 'Formation of phosphoribosyl pyrophosphate amidotransferase tetramer'
type: Control
data source: Reactome
xref: UnificationXref896
controlled: BiochemicalReaction63
control type: ACTIVATION
controller: 5'-Adenylic acid

'GMP [cytosol]' positively regulates 'Formation of phosphoribosyl pyrophosphate amidotransferase tetramer'
type: Control
data source: Reactome
xref: UnificationXref897
controlled: BiochemicalReaction63
control type: ACTIVATION
controller: Guanosine monophosphate

'GDP [cytosol]' negatively regulates 'IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]'
type: Control
data source: Reactome
xref: UnificationXref1015
controlled: BiochemicalReaction76
control type: INHIBITION
controller: Guanosine 5'-diphosphate

Control17
type: Control
data source: Reactome
xref: UnificationXref916
controlled: BiochemicalReaction65
control type: ACTIVATION
display name: 'Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer' positively regulates '5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate'

'XMP [cytosol]' negatively regulates 'IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]'
type: Control
data source: Reactome
xref: UnificationXref991
controlled: BiochemicalReaction74
control type: INHIBITION
controller: xanthosine 5'-monophosphate

http://identifiers.org/pubmed/19319844
type: PublicationXref
id: 19319844
author: Zempleni, J
author: Hassan, YI
author: Wijeratne, SS
db: Pubmed
title: Biotin
source: Biofactors 35:36-46
year: 2009

Astrocytic Glutamate-Glutamine Uptake And Metabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction190
evidence: Evidence320
xref: UnificationXref2317
xref: UnificationXref2318
pathway order: PathwayStep312
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/6105839
type: PublicationXref
id: 6105839
author: Jones, ME
db: Pubmed
title: Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.
source: Annu Rev Biochem 49:253-79
year: 1980

http://identifiers.org/pubmed/16169847
type: PublicationXref
id: 16169847
author: Treadwell, L
author: Warrington, JA
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins
source: J Biol Chem 280:38870-8
year: 2005

PublicationXref796
type: PublicationXref
id: 9781439818602
author: Kato, K
author: Numata, T
author: Kiyonaka, S
author: Mori, Y
author: Takahashi, N
db: ISBN
title: Chapter 3 Activation of TRP Channels in Mammalian Systems
source: TRP Channels (Book)
year: 2011

Antigen processing-Cross presentation
type: Pathway
data source: Reactome
pathway component: REACT 145275.5
evidence: Evidence436
xref: UnificationXref3021
xref: RelationshipXref502
xref: UnificationXref3020
pathway order: PathwayStep422
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

2-Deoxy-D-ribose 1-phosphate
type: SmallMoleculeReference
name: 2-Deoxy-D-ribose 1-phosphate [ChEBI:28542]
xref: UnificationXref1196

http://identifiers.org/pubmed/1985938
type: PublicationXref
id: 1985938
author: Parés, X
author: Moreno, A
db: Pubmed
title: Purification and characterization of a new alcohol dehydrogenase from human stomach.
source: J Biol Chem 266:1128-33
year: 1991

http://identifiers.org/pubmed/14514684
type: PublicationXref
id: 14514684
author: Rebholz, H
author: Foxon, R
author: Matsuka, G
author: Fenton, T
author: Valovka, T
author: Nemazanyy, I
author: Zhyvoloup, A
author: Filonenko, V
author: Wang, ML
author: Lyzogubov, V
author: Usenko, V
author: Gorbenko, O
author: Kyyamova, R
author: Gout, IT
author: Panasyuk, G
db: Pubmed
title: Subcellular localization and regulation of coenzyme A synthase
source: J Biol Chem 278:50316-21
year: 2003

http://identifiers.org/pubmed/18555844
type: PublicationXref
id: 18555844
author: Buehrer, B
author: Madan, AK
author: Fain, JN
author: Bahouth, SW
author: Tichansky, DS
db: Pubmed
title: Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
source: Metabolism 57:1005-15
year: 2008

http://identifiers.org/pubmed/17266529
type: PublicationXref
id: 17266529
author: Hyde, JE
db: Pubmed
title: Targeting purine and pyrimidine metabolism in human apicomplexan parasites
source: Curr Drug Targets 8:31-47
year: 2007

'Mg2+ [cytosol]' is required for 'ITPA hydrolyses dITP to dIMP'
type: Control
data source: Reactome
xref: UnificationXref1405
controlled: BiochemicalReaction106
control type: ACTIVATION
controller: Mg++

'Mg2+ [cytosol]' is required for 'ITPA hydrolyses XTP to XMP'
type: Control
data source: Reactome
xref: UnificationXref1411
controlled: BiochemicalReaction107
control type: ACTIVATION
controller: Mg++

'Mg2+ [cytosol]' is required for 'A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)'
type: Control
data source: Reactome
xref: UnificationXref1490
controlled: BiochemicalReaction116
control type: ACTIVATION
controller: Mg++

'NAcGlu [mitochondrial matrix]' positively regulates '2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]'
type: Control
data source: Reactome
xref: UnificationXref1790
controlled: BiochemicalReaction146
control type: ACTIVATION
controller: SmallMolecule343

'D-Fructose 1,6-bisphosphate [cytosol]' negatively regulates 'IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]'
type: Control
data source: Reactome
xref: UnificationXref1016
controlled: BiochemicalReaction76
control type: INHIBITION
controller: D-Fructose 1,6-bisphosphate

'GMP [cytosol]' negatively regulates 'IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]'
type: Control
data source: Reactome
xref: UnificationXref1017
controlled: BiochemicalReaction76
control type: INHIBITION
controller: Guanosine monophosphate

'ADS [cytosol]' negatively regulates 'IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]'
type: Control
data source: Reactome
xref: UnificationXref1018
controlled: BiochemicalReaction76
control type: INHIBITION
controller: N6-(1,2-Dicarboxyethyl)-AMP

'Mg2+ [cytosol]' is required for 'ITPA hydrolyses ITP to IMP'
type: Control
data source: Reactome
xref: UnificationXref1396
controlled: BiochemicalReaction105
control type: ACTIVATION
controller: Mg++

'Pb2+ [mitochondrial matrix]' negatively regulates 'FECH binds Fe2+ to PRIN9 to form heme'
type: Control
data source: Reactome
xref: UnificationXref2050
controlled: BiochemicalReaction170
control type: INHIBITION
controller: SmallMolecule388

Glucose metabolism
type: Pathway
data source: Reactome
pathway component: Glycolysis
pathway component: Gluconeogenesis
evidence: Evidence25
xref: UnificationXref218
xref: RelationshipXref25
xref: UnificationXref219
pathway order: PathwayStep14
pathway order: PathwayStep21
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10673423
type: PublicationXref
id: 10673423
author: Peake, SJ
author: Cotton, NP
author: Leonard, G
author: White, SA
author: Jackson, JB
author: McSweeney, S
db: Pubmed
title: The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria
source: Structure 8:1-12
year: 2000

http://identifiers.org/pubmed/16756494
type: PublicationXref
id: 16756494
author: Waterham, HR
author: Wanders, RJ
db: Pubmed
title: Biochemistry of mammalian peroxisomes revisited
source: Annu Rev Biochem 75:295-332
year: 2006

UnificationXref1709
type: UnificationXref
id: 4229949
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229949

RelationshipXref292
type: RelationshipXref
id: 4230979
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230979

RelationshipXref291
type: RelationshipXref
id: 4229859
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229859

RelationshipXref294
type: RelationshipXref
id: GO:0004028
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref293
type: RelationshipXref
id: GO:0000050
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1705
type: UnificationXref
id: CHEBI:15753
db: ChEBI

UnificationXref1706
type: UnificationXref
id: 70951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70951

UnificationXref1707
type: UnificationXref
id: REACT_2814
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2814.1

RelationshipXref290
type: RelationshipXref
id: GO:0004053
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1708
type: UnificationXref
id: Q7A875
db: UniProt

UnificationXref1702
type: UnificationXref
id: CHEBI:17082
db: ChEBI

RelationshipXref288
type: RelationshipXref
id: GO:0004056
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1701
type: UnificationXref
id: REACT_31534
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31534.10

RelationshipXref289
type: RelationshipXref
id: 4229865
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229865

UnificationXref1704
type: UnificationXref
id: REACT_21673
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21673.2

UnificationXref1703
type: UnificationXref
id: 508531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=508531

RelationshipXref284
type: RelationshipXref
id: GO:0004585
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref285
type: RelationshipXref
id: 4229853
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229853

UnificationXref1700
type: UnificationXref
id: 4231268
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231268

RelationshipXref286
type: RelationshipXref
id: GO:0004055
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref287
type: RelationshipXref
id: 4229871
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229871

RelationshipXref299
type: RelationshipXref
id: 4230583
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230583

RelationshipXref297
type: RelationshipXref
id: GO:0004111
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/15084262
type: PublicationXref
id: 15084262
author: Edgar, BA
author: Reis, T
db: Pubmed
title: Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
source: Cell 117:253-64
year: 2004

RelationshipXref298
type: RelationshipXref
id: 4230576
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230576

RelationshipXref295
type: RelationshipXref
id: 4230001
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230001

RelationshipXref296
type: RelationshipXref
id: GO:0045329
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:Q99U74
type: ProteinReference
xref: UnificationXref834
organism: BioSource1

UnificationXref1604
type: UnificationXref
id: 113585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113585

UnificationXref1605
type: UnificationXref
id: REACT_2690
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2690.2

UnificationXref1602
type: UnificationXref
id: REACT_103646
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103646.9

UnificationXref1603
type: UnificationXref
id: CHEBI:15729
db: ChEBI

http://identifiers.org/pubmed/15924268
type: PublicationXref
id: 15924268
author: Nejsum, LN
db: Pubmed
title: The renal plumbing system: aquaporin water channels
source: Cell Mol Life Sci 62:1692-706
year: 2005

UnificationXref1600
type: UnificationXref
id: REACT_98755
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98755.9

UnificationXref1601
type: UnificationXref
id: 4231331
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231331

http://identifiers.org/pubmed/1390320
type: PublicationXref
id: 1390320
author: Russell, DW
db: Pubmed
title: Cholesterol biosynthesis and metabolism
source: Cardiovasc Drugs Ther 6:103-10
year: 1992

http://identifiers.org/pubmed/16219661
type: PublicationXref
id: 16219661
author: Suzuki, Makoto
db: Pubmed
title: The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels
source: Exp. Physiol. 91:141-7
year: 2006

D-Fructose 2,6-bisphosphate [ChEBI:28602]
type: SmallMoleculeReference
name: D-Fructose 2,6-bisphosphate
xref: UnificationXref64

Coproporphyrinogen I
type: SmallMoleculeReference
name: Coproporphyrinogen I [ChEBI:3879]
xref: UnificationXref2015

UnificationXref1609
type: UnificationXref
id: P60298
db: UniProt

UnificationXref1608
type: UnificationXref
id: REACT_3509
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3509.2

UnificationXref1607
type: UnificationXref
id: 31339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31339

UnificationXref1606
type: UnificationXref
id: CHEBI:17232
db: ChEBI

UnificationXref1610
type: UnificationXref
id: MOD:00128
db: MOD

UnificationXref1611
type: UnificationXref
id: 4229876
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229876

UnificationXref1612
type: UnificationXref
id: P60296
db: UniProt

UnificationXref1613
type: UnificationXref
id: 4229880
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229880

http://identifiers.org/pubmed/11952783
type: PublicationXref
id: 11952783
author: Kurachi, Y
author: Kishida, K
author: Matsuzawa, Y
author: Makino, Y
author: Matsuda, M
author: Kondo, H
author: Nakamura, T
author: Kuriyama, H
author: Nagaretani, H
author: Maeda, N
author: Nishizawa, H
author: Funahashi, T
author: Shimomura, I
author: Kihara, S
db: Pubmed
title: Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation
source: Eur J Biochem 269:1814-26
year: 2002

UnificationXref1614
type: UnificationXref
id: 4229881
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229881

UnificationXref1615
type: UnificationXref
id: 4229882
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229882

UnificationXref1616
type: UnificationXref
id: 4229884
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229884

lysosomal lumen
type: CellularLocationVocabulary
xref: UnificationXref2679

http://identifiers.org/pubmed/1574589
type: PublicationXref
id: 1574589
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: De novo purine nucleotide biosynthesis
source: Prog Nucleic Acid Res Mol Biol 42:259-287
year: 1992

http://identifiers.org/pubmed/12445824
type: PublicationXref
id: 12445824
author: Ganapathy, V
author: Inoue, K
author: Zhuang, L
db: Pubmed
title: Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function
source: Biochem Biophys Res Commun 299:465-71
year: 2002

UnificationXref1618
type: UnificationXref
id: 4229885
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229885

http://identifiers.org/pubmed/16539657
type: PublicationXref
id: 16539657
author: Kakiuchi, C
author: Hayashi, A
author: Ishiwata, M
author: Kato, T
db: Pubmed
title: XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells
source: J Neurochem 97:545-55
year: 2006

UnificationXref1617
type: UnificationXref
id: REACT_113272
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113272.8

UnificationXref1619
type: UnificationXref
id: REACT_112121
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112121.8

http://identifiers.org/pubmed/11306702
type: PublicationXref
id: 11306702
author: Karlsson, A
author: Norda, A
author: Linden, K
author: Johansson, M
author: Van Rompay, AR
db: Pubmed
title: Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
source: Mol Pharmacol 59:1181-1186
year: 2001

UnificationXref1622
type: UnificationXref
id: REACT_117597
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117597.1

UnificationXref1623
type: UnificationXref
id: Q7A542
db: UniProt

UnificationXref1620
type: UnificationXref
id: CHEBI:30933
db: ChEBI

UnificationXref1621
type: UnificationXref
id: 977329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=977329

UnificationXref1626
type: UnificationXref
id: 4231083
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231083

UnificationXref1627
type: UnificationXref
id: REACT_134028
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134028.5

UnificationXref1624
type: UnificationXref
id: 4231080
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231080

UnificationXref1625
type: UnificationXref
id: 4231081
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231081

http://identifiers.org/pubmed/8101838
type: PublicationXref
id: 8101838
author: North, RA
author: Amara, SG
author: Murdoch, GH
author: Fairman, WA
author: Arriza, JL
author: Wu, YN
author: Kavanaugh, MP
db: Pubmed
title: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family
source: J Biol Chem 268:15329-32
year: 1993

http://identifiers.org/pubmed/10764807
type: PublicationXref
id: 10764807
author: Takeuchi, N
author: Shimada, N
author: Nishikawa, K
author: Yokogawa, T
author: Watanabe, K
author: Suzuki, T
author: Ueda, T
author: Benkowski, L
author: Spremulli, LL
author: Omori, A
db: Pubmed
title: Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase
source: J Biol Chem 275:19913-20
year: 2000

'Pi [cytosol]' is required for 'ribose phosphate diphosphokinase activity of phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens) [intracellular]'
type: Modulation
data source: Reactome
xref: UnificationXref296
controlled: Catalysis22
control type: ACTIVATION
controller: Phosphate

'Mg2+ [cytosol]' is required for 'ribose phosphate diphosphokinase activity of phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens) [intracellular]'
type: Modulation
data source: Reactome
xref: UnificationXref295
controlled: Catalysis22
control type: ACTIVATION
controller: Mg++

'NAcGlu [mitochondrial matrix]' positively regulates 'carbamoyl-phosphate synthase (ammonia) activity of Homologues of CPS1 [intracellular]'
type: Modulation
data source: Reactome
xref: UnificationXref1784
controlled: Catalysis140
control type: ACTIVATION
controller: SmallMolecule343

UnificationXref1629
type: UnificationXref
id: REACT_134228
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134228.5

UnificationXref1628
type: UnificationXref
id: 4231411
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231411

UnificationXref1630
type: UnificationXref
id: 4231264
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231264

UnificationXref1636
type: UnificationXref
id: 113576
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113576

UnificationXref1635
type: UnificationXref
id: CHEBI:28654
db: ChEBI

UnificationXref1638
type: UnificationXref
id: CHEBI:16530
db: ChEBI

UnificationXref1637
type: UnificationXref
id: REACT_5174
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5174.2

UnificationXref1632
type: UnificationXref
id: CHEBI:17865
db: ChEBI

UnificationXref1631
type: UnificationXref
id: REACT_112051
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112051.8

UnificationXref1634
type: UnificationXref
id: REACT_4718
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4718.2

UnificationXref1633
type: UnificationXref
id: 113598
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113598

UnificationXref1639
type: UnificationXref
id: 113584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113584

UnificationXref1641
type: UnificationXref
id: 508181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=508181

UnificationXref1640
type: UnificationXref
id: REACT_2393
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2393.2

UnificationXref1649
type: UnificationXref
id: CHEBI:15479
db: ChEBI

UnificationXref1648
type: UnificationXref
id: REACT_5465
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5465.1

UnificationXref1647
type: UnificationXref
id: 70718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70718

UnificationXref1646
type: UnificationXref
id: CHEBI:15477
db: ChEBI

UnificationXref1645
type: UnificationXref
id: REACT_5091
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5091.2

UnificationXref1644
type: UnificationXref
id: 70715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70715

UnificationXref1643
type: UnificationXref
id: CHEBI:15487
db: ChEBI

UnificationXref1642
type: UnificationXref
id: REACT_21879
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21879.1

http://identifiers.org/pubmed/18664523
type: PublicationXref
id: 18664523
author: Yamamoto, K
author: Kaufman, RJ
author: Suzuki, N
author: Yoshida, H
author: Mori, K
author: Okada, T
author: Wada, T
db: Pubmed
title: Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds
source: J Biochem 144:477-86
year: 2008

http://identifiers.org/pubmed/2324105
type: PublicationXref
id: 2324105
author: Strauss, AW
author: Haas, RC
db: Pubmed
title: Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes
source: J Biol Chem 265:6921-7
year: 1990

UnificationXref1650
type: UnificationXref
id: 70851
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70851

UnificationXref1652
type: UnificationXref
id: 508261
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=508261

UnificationXref1651
type: UnificationXref
id: REACT_4034
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4034.2

UnificationXref1654
type: UnificationXref
id: P65636
db: UniProt

UnificationXref1653
type: UnificationXref
id: REACT_21630
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21630.1

UnificationXref1656
type: UnificationXref
id: Q7A5F9
db: UniProt

UnificationXref1655
type: UnificationXref
id: 4229921
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229921

UnificationXref1658
type: UnificationXref
id: 4229926
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229926

UnificationXref1657
type: UnificationXref
id: 4229925
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229925

UnificationXref1659
type: UnificationXref
id: Q7A5F8
db: UniProt

http://identifiers.org/pubmed/8619816
type: PublicationXref
id: 8619816
author: Kondo, M
author: Itakura, M
author: Takahashi, Y
author: Moritani, M
author: Yoshimoto, K
author: Yamaoka, T
author: Fujimura, H
author: Ii, S
author: Iwahana, H
db: Pubmed
title: Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis
source: Biochem Biophys Res Commun 219:249-255
year: 1996

http://identifiers.org/pubmed/2914937
type: PublicationXref
id: 2914937
author: Zhang, Z
author: Korenfeld, C
author: Roman, D
author: Strauss, AW
author: Haas, RC
author: Perryman, B
db: Pubmed
title: Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase
source: J Biol Chem 264:2890-7
year: 1989

UnificationXref1663
type: UnificationXref
id: 4229911
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229911

UnificationXref1662
type: UnificationXref
id: 4229910
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229910

UnificationXref1661
type: UnificationXref
id: P99063
db: UniProt

UnificationXref1660
type: UnificationXref
id: 4229907
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229907

UnificationXref1667
type: UnificationXref
id: 4229903
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229903

UnificationXref1666
type: UnificationXref
id: Q7A5F7
db: UniProt

UnificationXref1665
type: UnificationXref
id: 4229900
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229900

http://identifiers.org/pubmed/19648010
type: PublicationXref
id: 19648010
author: Liu, C
author: Kang, JS
author: Derynck, R
db: Pubmed
title: New regulatory mechanisms of TGF-beta receptor function
source: Trends Cell Biol 19:385-94
year: 2009

UnificationXref1664
type: UnificationXref
id: Q820A6
db: UniProt

UnificationXref1669
type: UnificationXref
id: 4229912
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229912

UnificationXref1668
type: UnificationXref
id: 4229904
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229904

http://identifiers.org/pubmed/18566824
type: PublicationXref
id: 18566824
author: Takata, K
author: Tajika, Y
author: Hasegawa, T
author: Matsuzaki, T
author: Ablimit, A
db: Pubmed
title: Localization and trafficking of aquaporin 2 in the kidney
source: Histochem Cell Biol 130:197-209
year: 2008

http://identifiers.org/pubmed/18173545
type: PublicationXref
id: 18173545
author: Calamita, G
author: Svelto, M
author: Portincasa, P
author: Palasciano, G
db: Pubmed
title: Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
source: Eur J Clin Invest 38:1-10
year: 2008

RelationshipXref313
type: RelationshipXref
id: 4230766
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230766

RelationshipXref312
type: RelationshipXref
id: GO:0008453
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1679
type: UnificationXref
id: 30721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30721

RelationshipXref311
type: RelationshipXref
id: GO:0006590
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref310
type: RelationshipXref
id: 4230623
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230623

UnificationXref1677
type: UnificationXref
id: REACT_3169
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3169.2

UnificationXref1678
type: UnificationXref
id: CHEBI:30817
db: ChEBI

UnificationXref1675
type: UnificationXref
id: CHEBI:15971
db: ChEBI

UnificationXref1676
type: UnificationXref
id: 29612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29612

UnificationXref3153
type: UnificationXref
id: REACT_90632
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90632.9

UnificationXref1673
type: UnificationXref
id: 4231267
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231267

UnificationXref3152
type: UnificationXref
id: 4231383
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231383

UnificationXref1674
type: UnificationXref
id: REACT_33721
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33721.10

UnificationXref3155
type: UnificationXref
id: REACT_110630
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110630.9

UnificationXref1671
type: UnificationXref
id: 4229929
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229929

RelationshipXref319
type: RelationshipXref
id: GO:0047150
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref3154
type: UnificationXref
id: 4231354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231354

UnificationXref1672
type: UnificationXref
id: REACT_81262
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81262.9

RelationshipXref318
type: RelationshipXref
id: 4230437
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230437

RelationshipXref317
type: RelationshipXref
id: GO:0004478
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1670
type: UnificationXref
id: 4229927
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229927

RelationshipXref316
type: RelationshipXref
id: GO:0046487
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref315
type: RelationshipXref
id: 4230771
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230771

RelationshipXref314
type: RelationshipXref
id: GO:0030267
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/10581036
type: PublicationXref
id: 10581036
author: Joosse, M
author: Verbeek, E
author: Mancini, GM
author: Peltonen, L
author: Galjaard, H
author: Havelaar, AC
author: Aula, P
author: van der Spek, PJ
author: Beerens, CE
author: Aula, N
author: Verheijen, FW
db: Pubmed
title: A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases
source: Nat Genet 23:462-5
year: 1999

L-Leucine
type: SmallMoleculeReference
name: (2S)-alpha-2-Amino-4-methylvaleric acid
name: L-Leucine [ChEBI:15603]
name: (2S)-alpha-Leucine
name: 2-amino-4-methylvaleric acid
xref: UnificationXref2400

Deoxythymidine
type: SmallMoleculeReference
name: Thymidine [ChEBI:17748]
name: Thymidine
xref: UnificationXref1207

RelationshipXref300
type: RelationshipXref
id: GO:0006600
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref302
type: RelationshipXref
id: 4230645
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230645

RelationshipXref301
type: RelationshipXref
id: GO:0008792
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1686
type: UnificationXref
id: 34979
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=34979

UnificationXref1687
type: UnificationXref
id: REACT_3521
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3521.1

UnificationXref1688
type: UnificationXref
id: P67417
db: UniProt

UnificationXref1689
type: UnificationXref
id: 4229937
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229937

UnificationXref1682
type: UnificationXref
id: 4229932
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229932

RelationshipXref308
type: RelationshipXref
id: GO:0006595
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1683
type: UnificationXref
id: 4229934
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229934

RelationshipXref307
type: RelationshipXref
id: 4229896
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229896

UnificationXref1684
type: UnificationXref
id: REACT_97533
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97533.9

UnificationXref1685
type: UnificationXref
id: CHEBI:27384
db: ChEBI

RelationshipXref309
type: RelationshipXref
id: GO:0015111
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref304
type: RelationshipXref
id: 4230650
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230650

RelationshipXref303
type: RelationshipXref
id: GO:0008783
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1680
type: UnificationXref
id: REACT_4310
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4310.2

RelationshipXref306
type: RelationshipXref
id: GO:0004586
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1681
type: UnificationXref
id: P64416
db: UniProt

RelationshipXref305
type: RelationshipXref
id: GO:0097055
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref3140
type: UnificationXref
id: 4230214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230214

http://identifiers.org/pubmed/12369887
type: PublicationXref
id: 12369887
author: Danielson, PB
db: Pubmed
title: The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
source: Curr Drug Metab 3:561-97
year: 2002

http://identifiers.org/pubmed/10692433
type: PublicationXref
id: 10692433
author: Kijima, S
author: Fujita, M
author: Arata, Y
author: Ohtani, K
author: Kato, JY
db: Pubmed
title: Cdk2-dependent and -independent pathways in E2F-mediated S phase induction
source: J Biol Chem 275:6337-45
year: 2000

UnificationXref1699
type: UnificationXref
id: REACT_108263
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108263.9

Betaine [ChEBI:3073]
type: SmallMoleculeReference
name: Glycine betaine
name: Trimethylaminoacetate
name: Betaine
xref: UnificationXref1936

UnificationXref1697
type: UnificationXref
id: 4229943
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229943

UnificationXref1698
type: UnificationXref
id: 4229945
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229945

UnificationXref3139
type: UnificationXref
id: REACT_78880
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78880.9

UnificationXref3138
type: UnificationXref
id: 4231302
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231302

1,2,3-Propanetriol
type: SmallMoleculeReference
name: Glycerol
name: Glycerol [ChEBI:17754]
name: Glycerin
name: 1,2,3-Trihydroxypropane
xref: UnificationXref347

http://identifiers.org/pubmed/3932573
type: PublicationXref
id: 3932573
author: Kuhl, W
author: Beutler, E
db: Pubmed
title: Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism
source: J Lab Clin Med 106:573-7
year: 1985

UnificationXref3135
type: UnificationXref
id: REACT_33648
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33648.10

UnificationXref1691
type: UnificationXref
id: 4229940
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229940

UnificationXref3134
type: UnificationXref
id: 4231300
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231300

UnificationXref1692
type: UnificationXref
id: REACT_33847
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33847.10

UnificationXref3137
type: UnificationXref
id: REACT_88725
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88725.9

UnificationXref3136
type: UnificationXref
id: 4231301
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231301

UnificationXref1690
type: UnificationXref
id: 4229938
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229938

UnificationXref3131
type: UnificationXref
id: REACT_104313
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104313.9

UnificationXref1695
type: UnificationXref
id: REACT_3639
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3639.1

UnificationXref3130
type: UnificationXref
id: 4230336
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230336

UnificationXref1696
type: UnificationXref
id: P64418
db: UniProt

UnificationXref3133
type: UnificationXref
id: REACT_105235
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105235.9

UnificationXref1693
type: UnificationXref
id: CHEBI:18327
db: ChEBI

UnificationXref3132
type: UnificationXref
id: 4231303
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231303

UnificationXref1694
type: UnificationXref
id: 30158
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30158

UnificationXref3150
type: UnificationXref
id: 4231287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231287

UnificationXref3151
type: UnificationXref
id: REACT_102034
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102034.9

http://identifiers.org/pubmed/1894595
type: PublicationXref
id: 1894595
author: Burbaum, JJ
author: Schimmel, P
db: Pubmed
title: Structural relationships and the classification of aminoacyl-tRNA synthetases
source: J Biol Chem 266:16965-8
year: 1991

http://identifiers.org/pubmed/10656833
type: PublicationXref
id: 10656833
author: Arvai, AS
author: Tainer, JA
author: Putnam, CD
author: Bourne, Y
db: Pubmed
title: Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
source: J Mol Biol 296:295-309
year: 2000

15-Hydroperoxyicosatetraenoic acid
type: SmallMoleculeReference
name: 15-Hydroperoxyicosatetraenoate
name: (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
name: 15-Hydroperoxyeicosatetraenoate
name: 15-HPETE
name: 15-Hydroperoxyeicosatetraenoic acid
name: 15-HPETE [ChEBI:758]
xref: UnificationXref616

(5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoate
type: SmallMoleculeReference
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate [ChEBI:250]
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate
xref: UnificationXref639

carbovir monophosphate [ChEBI:64116]
type: SmallMoleculeReference
name: carbovir monophosphate
xref: UnificationXref2220

UnificationXref3149
type: UnificationXref
id: REACT_89319
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89319.9

UnificationXref3148
type: UnificationXref
id: 4231286
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231286

UnificationXref3147
type: UnificationXref
id: REACT_31652
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31652.10

UnificationXref3146
type: UnificationXref
id: 4230222
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230222

UnificationXref3145
type: UnificationXref
id: 4230220
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230220

UnificationXref3144
type: UnificationXref
id: MOD:00239
db: MOD

UnificationXref3143
type: UnificationXref
id: 4230218
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230218

UnificationXref3142
type: UnificationXref
id: 4230217
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230217

UnificationXref3141
type: UnificationXref
id: Q7A3F5
db: UniProt

5,6,7,8-Tetrahydrofolate
type: SmallMoleculeReference
name: Tetrahydrofolate
name: Tetrahydrofolate [ChEBI:15635]
name: THF
name: Tetrahydrofolic acid
xref: UnificationXref933

10-Formyl-THF
type: SmallMoleculeReference
name: 10-Formyltetrahydrofolate [ChEBI:15637]
name: 10-Formyltetrahydrofolate
xref: UnificationXref927

http://identifiers.org/pubmed/11001057
type: PublicationXref
id: 11001057
author: Rosenmund, C
author: Takamori, S
author: Rhee, JS
author: Jahn, R
db: Pubmed
title: Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons
source: Nature 407:189-94
year: 2000

http://identifiers.org/pubmed/8443237
type: PublicationXref
id: 8443237
author: Nilsson, A
author: Chen, Q
db: Pubmed
title: Desaturation and chain elongation of n - 3 and n - 6 polyunsaturated fatty acids in the human CaCo-2 cell line
source: Biochim Biophys Acta 1166:193-201
year: 1993

UnificationXref3110
type: UnificationXref
id: 4230320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230320

UnificationXref3111
type: UnificationXref
id: 4230321
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230321

UnificationXref3112
type: UnificationXref
id: REACT_77608
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77608.9

UnificationXref3113
type: UnificationXref
id: 4231299
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231299

UnificationXref3114
type: UnificationXref
id: REACT_88843
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88843.9

UnificationXref3115
type: UnificationXref
id: 4230330
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230330

UnificationXref3116
type: UnificationXref
id: 4230328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230328

UnificationXref3117
type: UnificationXref
id: 4230332
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230332

Urate [ChEBI:17775]
type: SmallMoleculeReference
name: Uric acid
name: Urate
xref: UnificationXref2941

UnificationXref3118
type: UnificationXref
id: REACT_94304
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94304.9

UnificationXref3119
type: UnificationXref
id: 4230333
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230333

5-HPETE
type: SmallMoleculeReference
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
name: 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate [ChEBI:2061]
name: (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
xref: UnificationXref589

Dihydrofolate [ChEBI:15633]
type: SmallMoleculeReference
name: dihydrofolic acid
name: 7,8-Dihydrofolic acid
name: Dihydrofolic acid
name: Dihydrofolate
name: 7,8-Dihydrofolate
xref: UnificationXref1183

Leukotriene B4
type: SmallMoleculeReference
name: (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate
name: Leukotriene B4 [ChEBI:6421]
name: (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoate
xref: UnificationXref579

http://identifiers.org/pubmed/8167409
type: PublicationXref
id: 8167409
author: McMahon, Jill A
author: Smolich, Beverly D
author: McMahon, Andrew P
author: Papkoff, Jackie
db: Pubmed
title: Wnt family proteins are secreted and associated with the cell surface
source: Mol. Biol. Cell 4:1267-75
year: 1993

http://identifiers.org/pubmed/9108121
type: PublicationXref
id: 9108121
author: Eliasof, S
author: Amara, SG
author: Arriza, JL
author: Kavanaugh, MP
db: Pubmed
title: Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
source: Proc Natl Acad Sci U S A 94:4155-60
year: 1997

UnificationXref3121
type: UnificationXref
id: REACT_92466
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92466.9

UnificationXref3122
type: UnificationXref
id: CHEBI:15901
db: ChEBI

UnificationXref3120
type: UnificationXref
id: 4230334
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230334

UnificationXref3125
type: UnificationXref
id: 4230335
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230335

UnificationXref3126
type: UnificationXref
id: REACT_84471
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84471.9

UnificationXref3123
type: UnificationXref
id: 30140
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30140

UnificationXref3124
type: UnificationXref
id: REACT_3731
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3731.1

UnificationXref3129
type: UnificationXref
id: REACT_4993
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4993.2

UnificationXref3127
type: UnificationXref
id: CHEBI:35877
db: ChEBI

UnificationXref3128
type: UnificationXref
id: 110228
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110228

5-Methyltetrahydrofolate
type: SmallMoleculeReference
name: 5-Methyltetrahydrofolate [ChEBI:15641]
xref: UnificationXref1510

http://identifiers.org/pubmed/20301244
type: PublicationXref
id: 20301244
author: Freeze, HH
author: Cummings, RD
author: Varki, A
author: Bertozzi, CR
author: Etzler, ME
author: Schachter, H
author: Stanley, P
author: Esko, JD
author: Hart, GW
author: Taniguchi, N
db: Pubmed
title: N-Glycans
year: 2009

http://identifiers.org/pubmed/3049610
type: PublicationXref
id: 3049610
author: Smith, BL
author: Agre, P
author: Denker, BM
author: Kuhajda, FP
db: Pubmed
title: Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules
source: J Biol Chem 263:15634-42
year: 1988

http://identifiers.org/pubmed/17478680
type: PublicationXref
id: 17478680
author: McMahon, HT
author: Kozlov, MM
author: Martens, S
db: Pubmed
title: How synaptotagmin promotes membrane fusion
source: Science 316:1205-8
year: 2007

http://identifiers.org/pubmed/17496910
type: PublicationXref
id: 17496910
author: McKay, MM
author: Morrison, DK
db: Pubmed
title: Integrating signals from RTKs to ERK/MAPK
source: Oncogene 26:3113-21
year: 2007

XMP
type: SmallMoleculeReference
name: xanthosine 5'-monophosphate
name: Xanthylic acid
name: xanthosine 5'-monophosphate [ChEBI:15652]
name: (9-D-Ribosylxanthine)-5'-phosphate
xref: UnificationXref983

http://identifiers.org/pubmed/9630604
type: PublicationXref
id: 9630604
author: Li, X
author: Hiratsuka, M
author: Suzuki, Y
author: Sakamoto, O
author: Narisawa, K
author: Aoki, Y
db: Pubmed
title: Identification of holocarboxylase synthetase (HCS) proteins in human placenta
source: Biochim. Biophys. Acta 1385:165-71
year: 1998

3-Phospho-D-glycerate
type: SmallMoleculeReference
name: 3-Phospho-D-glycerate [ChEBI:17794]
name: D-Glycerate 3-phosphate
xref: UnificationXref119

D-ribose 5-phosphate
type: SmallMoleculeReference
name: Ribose 5-phosphate
name: D-ribose 5-phosphate [ChEBI:17797]
xref: UnificationXref272

UnificationXref3103
type: UnificationXref
id: 4230324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230324

UnificationXref3104
type: UnificationXref
id: REACT_104485
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104485.9

http://identifiers.org/pubmed/19855401
type: PublicationXref
id: 19855401
author: Wilkinson, RJ
author: Boshoff, HI
author: Young, D
author: Dartois, V
author: Ehrt, S
author: Flynn, J
author: Barry CE, 3rd
author: Schnappinger, D
author: Dick, T
db: Pubmed
title: The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
source: Nat Rev Microbiol 7:845-55
year: 2009

UnificationXref3101
type: UnificationXref
id: 4230322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230322

UnificationXref3102
type: UnificationXref
id: 4230323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230323

UnificationXref3100
type: UnificationXref
id: REACT_90014
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_90014.9

UnificationXref3109
type: UnificationXref
id: 4230319
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230319

UnificationXref3107
type: UnificationXref
id: 4230327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230327

UnificationXref3108
type: UnificationXref
id: REACT_99237
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99237.9

UnificationXref3105
type: UnificationXref
id: 4230325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230325

UnificationXref3106
type: UnificationXref
id: 4230326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230326

http://identifiers.org/pubmed/17224163
type: PublicationXref
id: 17224163
author: Xie, XC
author: Wang, QH
author: Tong, YP
author: Li, SG
author: Zhou, HN
author: Li, SX
author: Han, Y
author: Gao, W
author: Zhang, ZY
author: Zhang, XC
author: Bi, RC
db: Pubmed
title: Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis
source: J Mol Biol 366:1603-14
year: 2007

RelationshipXref129
type: RelationshipXref
id: 4231022
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231022

RelationshipXref128
type: RelationshipXref
id: GO:0047988
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref127
type: RelationshipXref
id: GO:0006099
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref126
type: RelationshipXref
id: 4229963
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229963

RelationshipXref125
type: RelationshipXref
id: GO:0004333
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref124
type: RelationshipXref
id: 4229976
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229976

http://identifiers.org/pubmed/16407156
type: PublicationXref
id: 16407156
author: Beitz, E
author: Wu, B
author: Holm, LM
author: Zeuthen, T
author: Schultz, JE
db: Pubmed
title: Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons
source: Proc Natl Acad Sci U S A 103:269-74
year: 2006

RelationshipXref123
type: RelationshipXref
id: GO:0034602
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref122
type: RelationshipXref
id: 4230974
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230974

RelationshipXref121
type: RelationshipXref
id: GO:0008746
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/12801959
type: PublicationXref
id: 12801959
author: Burghardt, B
author: Nielsen, S
author: Elkaer, ML
author: Rácz, GZ
author: Kwon, TH
author: Steward, MC
author: Varga, G
db: Pubmed
title: Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas
source: Gut 52:1008-16
year: 2003

Dephospho-CoA
type: SmallMoleculeReference
name: Dephospho-CoA [ChEBI:4436]
xref: UnificationXref1450

RelationshipXref120
type: RelationshipXref
id: 4229957
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229957

HMG-CoA
type: SmallMoleculeReference
name: (S)-3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA
name: (S)-3-Hydroxy-3-methylglutaryl-CoA [ChEBI:15467]
name: Hydroxymethylglutaroyl coenzyme A
name: Hydroxymethylglutaryl-CoA
xref: UnificationXref381

RelationshipXref139
type: RelationshipXref
id: 4230189
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230189

RelationshipXref138
type: RelationshipXref
id: GO:0004641
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref135
type: RelationshipXref
id: 4230193
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230193

RelationshipXref134
type: RelationshipXref
id: GO:0004637
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref137
type: RelationshipXref
id: 4230191
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230191

RelationshipXref136
type: RelationshipXref
id: GO:0004644
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref131
type: RelationshipXref
id: GO:0044237
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref130
type: RelationshipXref
id: GO:0006103
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref133
type: RelationshipXref
id: 4230199
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230199

RelationshipXref132
type: RelationshipXref
id: GO:0004044
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref140
type: RelationshipXref
id: GO:0004638
db: GENE ONTOLOGY
relationship type: MI:0355

Conjugation of benzoate with glycine
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction179
evidence: Evidence285
xref: UnificationXref2183
xref: UnificationXref2182
xref: RelationshipXref347
pathway order: PathwayStep280
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P60088
type: ProteinReference
xref: UnificationXref1819
organism: BioSource1

RelationshipXref149
type: RelationshipXref
id: 4230168
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230168

http://identifiers.org/pubmed/7396409
type: PublicationXref
id: 7396409
author: Hopkinson, DA
author: Spencer, N
db: Pubmed
title: Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE)
source: Ann Hum Genet 43:335-42
year: 1980

RelationshipXref144
type: RelationshipXref
id: GO:0004018
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref143
type: RelationshipXref
id: 4230182
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230182

RelationshipXref142
type: RelationshipXref
id: GO:0004639
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref141
type: RelationshipXref
id: 4230184
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230184

http://identifiers.org/pubmed/23256519
type: PublicationXref
id: 23256519
author: Lee, Ethan
author: Wang, Xiaoxi
author: Saito-Diaz, Kenyi
author: Wallace, Heather A
author: Chen, Tony W
author: Thorne, Curtis A
author: Page-McCaw, Andrea
db: Pubmed
title: The way Wnt works: Components and mechanism
source: Growth Factors 31:1-31
year: 2013

RelationshipXref148
type: RelationshipXref
id: GO:0003937
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref147
type: RelationshipXref
id: 4230170
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230170

RelationshipXref146
type: RelationshipXref
id: GO:0004643
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref145
type: RelationshipXref
id: 4230176
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230176

RelationshipXref150
type: RelationshipXref
id: GO:0003938
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref151
type: RelationshipXref
id: 4230161
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230161

Protoporphyrinogen IX [ChEBI:8593]
type: SmallMoleculeReference
name: Protoporphyrinogen IX
xref: UnificationXref2023

RelationshipXref153
type: RelationshipXref
id: 4230155
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230155

RelationshipXref152
type: RelationshipXref
id: GO:0003921
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref155
type: RelationshipXref
id: 4230376
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230376

RelationshipXref154
type: RelationshipXref
id: GO:0004019
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref157
type: RelationshipXref
id: GO:0003876
db: GENE ONTOLOGY
relationship type: MI:0355

Protoporphyrin [ChEBI:8592]
type: SmallMoleculeReference
name: Protoporphyrin
name: Protoporphyrin IX
name: Porphyrinogen IX
xref: UnificationXref2026

RelationshipXref156
type: RelationshipXref
id: GO:0009168
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref159
type: RelationshipXref
id: GO:0003999
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref158
type: RelationshipXref
id: 4230265
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230265

Coproporphyrinogen III [ChEBI:3880]
type: SmallMoleculeReference
name: Coproporphyrinogen III
xref: UnificationXref2004

RelationshipXref160
type: RelationshipXref
id: 4230232
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230232

RelationshipXref161
type: RelationshipXref
id: GO:0004422
db: GENE ONTOLOGY
relationship type: MI:0355

Uroporphyrinogen III [ChEBI:9905]
type: SmallMoleculeReference
name: Uroporphyrinogen III
xref: UnificationXref2001

RelationshipXref162
type: RelationshipXref
id: 4230238
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230238

http://identifiers.org/pubmed/6248551
type: PublicationXref
id: 6248551
author: Miller, RL
author: Miller, WH
db: Pubmed
title: Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
source: J Biol Chem 255:7204-7207
year: 1980

http://identifiers.org/pubmed/6300847
type: PublicationXref
id: 6300847
author: Filpula, D
author: Johnson, GG
author: Esty, AC
author: Jolly, DJ
author: Okayama, H
author: Bohlen, P
author: Berg, P
author: Hunkapillar, T
author: Friedmann, T
author: Shively, JE
db: Pubmed
title: Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase
source: Proc Natl Acad Sci U S A 80:477-81
year: 1983

Pentose phosphate pathway (hexose monophosphate shunt)
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction19
pathway component: BiochemicalReaction18
pathway component: BiochemicalReaction17
pathway component: BiochemicalReaction21
pathway component: BiochemicalReaction16
pathway component: BiochemicalReaction20
evidence: Evidence34
xref: RelationshipXref37
xref: UnificationXref281
xref: UnificationXref282
pathway order: PathwayStep30
pathway order: PathwayStep28
pathway order: PathwayStep29
pathway order: PathwayStep27
pathway order: PathwayStep25
pathway order: PathwayStep26
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Lipid digestion, mobilization, and transport
type: Pathway
data source: Reactome
pathway component: REACT 154910.3
evidence: Evidence43
xref: UnificationXref363
xref: UnificationXref362
pathway order: PathwayStep39
display name: Lipid and lipoprotein metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/21550412
type: PublicationXref
id: 21550412
author: Crabtree, MJ
author: Channon, KM
db: Pubmed
title: Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
source: Nitric Oxide 25:81-8
year: 2011

Dimethylglycine
type: SmallMoleculeReference
name: N,N-Dimethylglycine
name: N,N-Dimethylglycine [ChEBI:7077]
xref: UnificationXref1942

3,5-Dihydroxy-3-methylvaleric acid
type: SmallMoleculeReference
name: (R)-Mevalonate
name: (R)-Mevalonate [ChEBI:345]
name: Mevalonic acid
xref: UnificationXref442

http://identifiers.org/pubmed/9374640
type: PublicationXref
id: 9374640
author: Christensen, BM
author: Agre, P
author: King, LS
author: Nielsen, S
db: Pubmed
title: Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
source: Am J Physiol 273:C1549-61
year: 1997

http://identifiers.org/pubmed/12107270
type: PublicationXref
id: 12107270
author: Schlumberger, M
author: Leblanc, G
author: Rodriguez, AM
author: Perron, B
author: Pourcher, T
author: Caillou, B
author: Bidart, JM
author: Lacroix, L
db: Pubmed
title: Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes
source: J Clin Endocrinol Metab 87:3500-3
year: 2002

http://identifiers.org/pubmed/8428933
type: PublicationXref
id: 8428933
author: Doroshow, JH
author: Esworthy, RS
author: Chu, FF
db: Pubmed
title: Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
source: J Biol Chem 268:2571-6
year: 1993

http://identifiers.org/pubmed/9374639
type: PublicationXref
id: 9374639
author: Agre, P
author: Nielsen, S
author: King, LS
db: Pubmed
title: Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat
source: Am J Physiol 273:C1541-8
year: 1997

2'-deoxyadenosine 5'-monophosphate [ChEBI:17713]
type: SmallMoleculeReference
name: deoxyadenylic acid
name: dAMP
name: 2'-deoxyadenosine 5'-monophosphate
xref: UnificationXref286

http://identifiers.org/pubmed/6323448
type: PublicationXref
id: 6323448
author: Cline, A
author: Moulton, AD
author: Nienhuis, AW
author: Chen, MJ
author: Humphries, RK
author: Shimada, T
author: Maizel, J
db: Pubmed
title: The functional human dihydrofolate reductase gene
source: J Biol Chem 259:3933-43
year: 1984

Isovaleryl-CoA
type: SmallMoleculeReference
name: 3-Methylbutanoyl-CoA
name: 3-Methylbutanoyl-CoA [ChEBI:15487]
xref: UnificationXref1643

RelationshipXref100
type: RelationshipXref
id: GO:0019369
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref103
type: RelationshipXref
id: GO:0030148
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref104
type: RelationshipXref
id: GO:0006665
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref101
type: RelationshipXref
id: GO:0047560
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref102
type: RelationshipXref
id: 4230857
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230857

RelationshipXref107
type: RelationshipXref
id: GO:0043430
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref108
type: RelationshipXref
id: 4231196
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231196

RelationshipXref105
type: RelationshipXref
id: GO:0097269
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref106
type: RelationshipXref
id: 4231205
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231205

RelationshipXref109
type: RelationshipXref
id: GO:0006744
db: GENE ONTOLOGY
relationship type: MI:0359

PublicationXref809
type: PublicationXref
id: 0-87893-741-2
author: Purves, D
db: ISBN
title: Chapter 4: Channels and Transporters
source: Neuroscience (2nd ed.) (Book)
year: 2001

Isobutyryl-CoA
type: SmallMoleculeReference
name: 2-Methylpropanoyl-CoA [ChEBI:15479]
name: 2-Methylpropanoyl-CoA
name: 2-Methylpropionyl-CoA
xref: UnificationXref1649

RelationshipXref110
type: RelationshipXref
id: GO:0031325
db: GENE ONTOLOGY
relationship type: MI:0359

2-Methylbutyryl-CoA
type: SmallMoleculeReference
name: 2-Methylbutanoyl-CoA [ChEBI:15477]
name: 2-Methylbutanoyl-CoA
xref: UnificationXref1646

RelationshipXref111
type: RelationshipXref
id: GO:0006112
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref112
type: RelationshipXref
id: GO:0050999
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref113
type: RelationshipXref
id: GO:0004146
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref114
type: RelationshipXref
id: 4231126
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231126

But-2-enoyl-CoA
type: SmallMoleculeReference
name: Crotonyl-CoA
name: Crotonoyl-CoA [ChEBI:15473]
name: trans-But-2-enoyl-CoA
name: 2-Butenoyl-CoA
name: Crotonoyl-CoA
xref: UnificationXref1720

RelationshipXref115
type: RelationshipXref
id: GO:0046209
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref116
type: RelationshipXref
id: GO:0004459
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref117
type: RelationshipXref
id: 4229832
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229832

RelationshipXref118
type: RelationshipXref
id: GO:0006090
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref119
type: RelationshipXref
id: GO:0004108
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/14514735
type: PublicationXref
id: 14514735
author: Walker, RJ
author: Bedford, JJ
author: Leader, JP
db: Pubmed
title: Aquaporin expression in normal human kidney and in renal disease
source: J Am Soc Nephrol 14:2581-7
year: 2003

http://identifiers.org/pubmed/6816802
type: PublicationXref
id: 6816802
author: Simon, TC
author: Bryant, RW
author: Bailey, JM
db: Pubmed
title: Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway
source: J Biol Chem 257:14937-43
year: 1982

phosphofructokinase, P2L2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry10
component stoichiometry: Stoichiometry11
component: PFK-B
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref89
cellular location: intracellular
comment: Reactome DB_ID: 4229779

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5C9
data source: Reactome
name: Q7A5C9
name: Cytidine deaminase
name: Cytidine aminohydrolase
xref: UnificationXref1254
feature: FragmentFeature89
cellular location: intracellular
comment: Reactome DB_ID: 4230136
display name: CDA

phosphofructokinase, P3L complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry9
component stoichiometry: Stoichiometry8
component: PFK-B
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref88
cellular location: intracellular
comment: Reactome DB_ID: 4229778

alpha-linolenic acid (ALA) metabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction38
evidence: Evidence72
xref: UnificationXref544
xref: UnificationXref543
xref: RelationshipXref83
pathway order: PathwayStep68
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

triosephosphate isomerase dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry14
component: P99133
xref: UnificationXref113
cellular location: intracellular
comment: Reactome DB_ID: 4229769

phosphofructokinase, PL3 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry12
component stoichiometry: Stoichiometry13
component: PFK-B
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref90
cellular location: intracellular
comment: Reactome DB_ID: 4229780

enolase 1 dimer, (alpha) (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry18
component stoichiometry: Stoichiometry17
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref141
cellular location: intracellular
comment: Reactome DB_ID: 4229806

Thymidine phosphorylase precursor
type: Protein
entity reference: Q7A4D0
data source: Reactome
name: Thymidine phosphorylase precursor (EC 2.4.2.4) (TdRPase) (TP) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (Gliostatin)
name: Note: the coordinates are copied over from Homo sapiens.
name: endothelial cell growth factor 1 (platelet-derived)
name: TYMP
name: PD-ECGF
name: TdRPase
name: Q7A4D0
name: thymidine phosphorylase
name: Gliostatin
name: Platelet-derived endothelial cell growth factor
xref: UnificationXref1216
feature: FragmentFeature85
cellular location: intracellular
comment: Reactome DB_ID: 4230389
display name: TP

http://identifiers.org/pubmed/3297964
type: PublicationXref
id: 3297964
author: Köhrle, J
author: Hesch, RD
author: Brabant, G
db: Pubmed
title: Metabolism of the thyroid hormones
source: Horm Res 26:58-78
year: 1987

phosphoglycerate kinase 1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry15
component stoichiometry: Stoichiometry16
component: Mg++
component: PRP 2
xref: UnificationXref127
cellular location: intracellular
comment: Reactome DB_ID: 4229800

UCK 1
type: Protein
entity reference: P67411
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Uridine monophosphokinase 1
name: Cytidine monophosphokinase 1
name: P67411
name: Uridine-cytidine kinase 1
xref: UnificationXref1234
feature: FragmentFeature86
cellular location: intracellular
comment: Reactome DB_ID: 4230124
display name: UCK1

pyruvate kinase M1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry20
component stoichiometry: Stoichiometry19
component stoichiometry: Stoichiometry21
component: Potassium
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref151
cellular location: intracellular
comment: Reactome DB_ID: 4230025

Uridine monophosphokinase 2
type: Protein
entity reference: P67411
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Cytidine monophosphokinase 2
name: P67411
name: Uridine-cytidine kinase 2
name: UCK2(2-261)
xref: UnificationXref1238
feature: FragmentFeature87
cellular location: intracellular
comment: Reactome DB_ID: 4230303
display name: UCK 2

pyruvate kinase tetramer
type: Complex
data source: Reactome
member physical entity: pyruvate kinase complex, liver and RBC (name copied from entity in Homo sapiens)
member physical entity: pyruvate kinase M1 complex (name copied from entity in Homo sapiens)
xref: UnificationXref153
cellular location: intracellular
comment: Reactome DB_ID: 4230028
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P65231
data source: Reactome
name: Thymidine kinase, cytosolic
name: TK1(1-234)
name: Thymidine kinase, cytosolic (EC 2.7.1.21)
name: thymidine kinase 1, soluble
xref: UnificationXref1242
feature: FragmentFeature88
cellular location: intracellular
comment: Reactome DB_ID: 4230142
display name: P65231

pyruvate carboxylase holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry27
component stoichiometry: Stoichiometry26
component stoichiometry: Stoichiometry25
component: Mn(III)
component: Note: the coordinates are copied over from Homo sapiens.
component: Coenzyme R
xref: UnificationXref195
cellular location: intracellular
comment: Reactome DB_ID: 4229812

Dihydroorotate oxidase
type: Protein
entity reference: Q7A3B6
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7A3B6
name: Dihydroorotate dehydrogenase, mitochondrial precursor
name: DHOdehase
name: dihydroorotate dehydrogenase
name: Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase) (Fragment)
xref: UnificationXref1150
feature: FragmentFeature81
cellular location: intracellular
comment: Reactome DB_ID: 4230095
display name: DHODH

pyruvate kinase complex, liver and RBC (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry24
component stoichiometry: Stoichiometry23
component stoichiometry: Stoichiometry22
component: Note: the coordinates are copied over from Homo sapiens.
component: Potassium
component: Mg++
xref: UnificationXref152
cellular location: intracellular
comment: Reactome DB_ID: 4230027

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99144
data source: Reactome
name: Orotate phosphoribosyltransferase
name: UMPS(2-480)
name: OMPdecase
name: OPRtase
name: UMP synthase
name: uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
name: Uridine 5'-monophosphate synthase
name: Uridine 5'-monophosphate synthase (UMP synthase) (Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRtase); Orotidine 5'- phosphate decarboxylase (EC 4.1.1.23) (OMPdecase))
name: P99144
name: Orotidine 5'- phosphate decarboxylase
xref: UnificationXref1160
feature: FragmentFeature82
cellular location: intracellular
comment: Reactome DB_ID: 4230087
display name: UMPS

Q7A5B8
type: Protein
entity reference: UniProt:Q7A5B8
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Deoxycytidylate deaminase
name: dCMP deaminase
xref: UnificationXref1179
feature: FragmentFeature83
cellular location: intracellular
comment: Reactome DB_ID: 4230118
display name: DCTD

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P67047
data source: Reactome
name: TYMS
name: TSase
name: P67047
name: Thymidylate synthase
xref: UnificationXref1190
feature: FragmentFeature84
cellular location: intracellular
comment: Reactome DB_ID: 4230130
display name: TS

http://identifiers.org/pubmed/6311078
type: PublicationXref
id: 6311078
author: Hammarström, Sven
db: Pubmed
title: Leukotrienes
source: Annu Rev Biochem 52:355-77
year: 1983

http://identifiers.org/pubmed/8892014
type: PublicationXref
id: 8892014
author: Treacy, E
author: Thompson, GN
author: Pitt, JJ
author: Cotton, RG
author: Seller, K
author: Ramus, S
db: Pubmed
title: In vivo disposal of phenylalanine in phenylketonuria: a study of two siblings
source: J Inherit Metab Dis 19:595-602
year: 1996

http://identifiers.org/pubmed/12126930
type: PublicationXref
id: 12126930
author: Jakobs, C
author: Patel, A
author: Geraghty, MT
author: Thomas, GH
author: Schor, DS
author: Salomons, GS
author: Goh, DL
db: Pubmed
title: Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
source: Mol Genet Metab 76:172-80
year: 2002

haem o
type: SmallMoleculeReference
name: heme o [ChEBI:24480]
name: heme o
xref: UnificationXref2053

P99106
type: Protein
entity reference: P99106
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: IMP (inosine monophosphate) dehydrogenase 1
name: Inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1)
name: IMP dehydrogenase 1
name: IMPDH-I
name: Inosine-5'-monophosphate dehydrogenase 1
name: IMPD 1
xref: UnificationXref987
feature: FragmentFeature69
cellular location: intracellular
comment: Reactome DB_ID: 4230159
display name: IMPDH1

HSD11B1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry43
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref474
cellular location: intracellular
comment: Reactome DB_ID: 4230516

P99105
type: Protein
entity reference: P99105
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: guanine monophosphate synthetase
name: Glutamine amidotransferase
name: GMP synthetase
name: GMP synthase (glutamine-hydrolyzing)
xref: UnificationXref993
feature: FragmentFeature70
cellular location: intracellular
comment: Reactome DB_ID: 4230154
display name: GMPS

MVD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry42
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref461
cellular location: intracellular
comment: Reactome DB_ID: 4230500

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99099
data source: Reactome
name: IMP--aspartate ligase 1
name: AMPSase 1
name: P99099
name: Adenylosuccinate synthetase isozyme 1
name: AdSS 1
name: adenylosuccinate synthetase 1
name: adenylosuccinate synthetase like 1
xref: UnificationXref1006
feature: FragmentFeature71
cellular location: intracellular
comment: Reactome DB_ID: 4230369
display name: ADSSL1

ACHE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry45
component: Q7A3P6
xref: UnificationXref511
cellular location: plasma membrane
comment: Reactome DB_ID: 4230663

PCYT2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry44
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref495
cellular location: intracellular
comment: Reactome DB_ID: 4231122

MVK dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry41
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref450
cellular location: intracellular
comment: Reactome DB_ID: 4230494

CEL:bile salt complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry39
component stoichiometry: Stoichiometry38
component: bile salts and acids
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref340
cellular location: extracellular region
comment: Reactome DB_ID: 4230506

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64173
data source: Reactome
name: P64173
name: Fumarase
name: fumarate hydratase
name: Fumarate hydratase, mitochondrial
xref: UnificationXref851
feature: FragmentFeature63
cellular location: intracellular
comment: Reactome DB_ID: 4229961
display name: FH

Q7A843
type: Protein
entity reference: Q7A843
data source: Reactome
xref: UnificationXref869
cellular location: intracellular
comment: Reactome DB_ID: 4231021

P99164
type: Protein
entity reference: P99164
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: GPAT
name: Glutamine phosphoribosylpyrophosphate amidotransferase
name: Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT)
name: ATASE
name: Amidophosphoribosyltransferase precursor
name: phosphoribosyl pyrophosphate amidotransferase
name: glutamine phosphoribosylpyrophosphate amidotransferase
name: amidophosphoribosyltransferase
xref: UnificationXref887
feature: FragmentFeature64
cellular location: intracellular
comment: Reactome DB_ID: 4230197
display name: PPAT

P99163
type: Protein
entity reference: P99163
data source: Reactome
name: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
name: GAR transformylase
name: Trifunctional purine biosynthetic protein adenosine-3 (Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase))
name: Trifunctional purine biosynthetic protein adenosine-3
name: GARS
name: AIRS
name: 5'-phosphoribosylglycinamide transformylase
name: Phosphoribosylamine--glycine ligase
name: Glycinamide ribonucleotide synthetase
name: Note: the coordinates are copied over from Homo sapiens.
name: AIR synthase
name: Phosphoribosylformylglycinamidine cyclo-ligase
name: Phosphoribosylglycinamide formyltransferase
name: Phosphoribosyl-aminoimidazole synthetase
name: GART(2-1010)
name: Phosphoribosylglycinamide synthetase
xref: UnificationXref924
feature: FragmentFeature65
cellular location: intracellular
comment: Reactome DB_ID: 4230188
display name: GART

PCYT1 dimer
type: Complex
data source: Reactome
member physical entity: PCYT1B dimer (name copied from entity in Homo sapiens)
member physical entity: PCYT1A dimer (name copied from entity in Homo sapiens)
xref: UnificationXref526
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231118

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P99064
data source: Reactome
name: AIR carboxylase
name: Phosphoribosylaminoimidazole carboxylase
name: Phosphoribosylaminoimidazole- succinocarboxamide synthase
name: SAICAR synthetase
name: P99064
name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthase
name: PAICS
name: Multifunctional protein ADE2
xref: UnificationXref950
feature: FragmentFeature66
cellular location: intracellular
comment: Reactome DB_ID: 4230180
display name: AIRC

ACHE tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry46
component: Q7A3P6
xref: UnificationXref512
cellular location: plasma membrane
comment: Reactome DB_ID: 4230664

ASASE
type: Protein
entity reference: Q7A4Q3
data source: Reactome
name: Adenylosuccinase
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylosuccinate lyase
name: ADSL
name: Q7A4Q3
xref: UnificationXref969
feature: FragmentFeature67
cellular location: intracellular
comment: Reactome DB_ID: 4230174
display name: ASL

PCYT1B dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry48
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref525
cellular location: intracellular
comment: Reactome DB_ID: 4231117

P67544
type: Protein
entity reference: P67544
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Inosinicase
name: Bifunctional purine biosynthesis protein PURH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC))
name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
name: IMP cyclohydrolase
name: Bifunctional purine biosynthesis protein PURH
name: IMP synthetase
name: AICAR transformylase
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase
xref: UnificationXref977
feature: FragmentFeature68
cellular location: intracellular
comment: Reactome DB_ID: 4230166
display name: ATIC

PCYT1A dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry47
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref523
cellular location: intracellular
comment: Reactome DB_ID: 4231115

http://identifiers.org/pubmed/14609716
type: PublicationXref
id: 14609716
author: Karlsson, A
author: Johansson, M
author: Van Rompay, AR
db: Pubmed
title: Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
source: Pharmacol Ther 100:119-139
year: 2003

G6PD tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry34
component stoichiometry: Stoichiometry33
component: SmallMolecule4
component: Q7A5G7
xref: UnificationXref245
cellular location: intracellular
comment: Reactome DB_ID: 4229762

G6PD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry32
component stoichiometry: Stoichiometry31
component: SmallMolecule4
component: Q7A5G7
xref: UnificationXref244
cellular location: intracellular
comment: Reactome DB_ID: 4229761

G6PD dimer and tetramer
type: Complex
data source: Reactome
member physical entity: G6PD dimer (name copied from entity in Homo sapiens)
member physical entity: G6PD tetramer (name copied from entity in Homo sapiens)
xref: UnificationXref246
cellular location: intracellular
comment: Reactome DB_ID: 4229763
comment: Converted from EntitySet in Reactome

Homologues of CAD
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: P63740
xref: UnificationXref1125
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230101

GALE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry30
component stoichiometry: Stoichiometry29
component: DPN
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref231
cellular location: intracellular
comment: Reactome DB_ID: 4229755

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99147
data source: Reactome
name: Aspartate carbamoyltransferase
name: P99147
name: Dihydroorotase
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref1122
feature: FragmentFeature79
cellular location: intracellular
comment: Reactome DB_ID: 4230099
display name: CAD

phosphoPFKFB1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry28
component: phospho-p-S33-PFKFB1(1-471)
xref: UnificationXref211
cellular location: intracellular
comment: Reactome DB_ID: 4229749

http://identifiers.org/pubmed/12859189
type: PublicationXref
id: 12859189
author: Emig, FA
author: Shin, H
author: Traish, AM
author: Colleluori, DM
author: Cama, E
author: Christianson, DW
author: Kim, NN
author: Ash, DE
author: Kim, SW
db: Pubmed
title: Human arginase II: crystal structure and physiological role in male and female sexual arousal
source: Biochemistry 42:8445-51
year: 2003

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99119
data source: Reactome
name: AMP deaminase 3
name: Erythrocyte AMP deaminase
name: P99119
name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)
name: AMP deaminase isoform E
name: erythrocyte AMP deaminase
xref: UnificationXref1026
feature: FragmentFeature73
cellular location: intracellular
comment: Reactome DB_ID: 4230261
display name: AMPD3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P65256
data source: Reactome
name: P65256
name: AMP deaminase 3
name: Erythrocyte AMP deaminase
name: AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase)
name: AMP deaminase isoform E
name: erythrocyte AMP deaminase
xref: UnificationXref1027
feature: FragmentFeature74
cellular location: intracellular
comment: Reactome DB_ID: 4230262
display name: AMPD3

IMP--aspartate ligase 2
type: Protein
entity reference: P99099
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)
name: ADSS(2-456)
name: AMPSase 2
name: Adenylosuccinate synthetase 2
name: adenylosuccinate synthetase
name: P99099
xref: UnificationXref1009
feature: FragmentFeature72
cellular location: intracellular
comment: Reactome DB_ID: 4230372
display name: AdSS 2

Homologues of AMPD3
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1028
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230263

dimerized CEL:bile salt complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry40
component: CEL:bile salt complex (name copied from entity in Homo sapiens)
xref: UnificationXref341
cellular location: extracellular region
comment: Reactome DB_ID: 4230507

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99XE9
data source: Reactome
name: 5'-NT
name: 5'-nucleotidase, ecto (CD73)
name: 5'-nucleotidase precursor
name: CD73 antigen
name: Q99XE9
name: Ecto-5'-nucleotidase
xref: UnificationXref1084
feature: FragmentFeature77
cellular location: plasma membrane
comment: Reactome DB_ID: 4230272
display name: NT5E

phosphoribosyl pyrophosphate synthetase holoenzyme
type: Complex
data source: Reactome
member physical entity: phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref299
cellular location: intracellular
comment: Reactome DB_ID: 4230113
comment: Converted from EntitySet in Reactome

phosphoribosyl pyrophosphate synthetase 1 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry37
component: P65237
xref: UnificationXref294
cellular location: intracellular
comment: Reactome DB_ID: 4230112

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5T2
data source: Reactome
name: Q7A5T2
name: Catalase apoprotein (EC 1.11.1.6)
name: Catalase
name: CATA_HUMAN
xref: UnificationXref1106
feature: FragmentFeature78
cellular location: intracellular
comment: Reactome DB_ID: 4230255
display name: CAT

Adenine phosphoribosyltransferase
type: Protein
entity reference: UniProt:P68779
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: P68779
xref: UnificationXref1036
feature: FragmentFeature75
cellular location: intracellular
comment: Reactome DB_ID: 4230230
display name: APRT

RPE dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry36
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref267
cellular location: intracellular
comment: Reactome DB_ID: 4230012

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P99085
data source: Reactome
name: P99085
name: HGPRTase
name: Hypoxanthine-guanine phosphoribosyltransferase
name: HGPRT
xref: UnificationXref1051
feature: FragmentFeature76
cellular location: intracellular
comment: Reactome DB_ID: 4230236
display name: HPRT1

PGD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry35
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref259
cellular location: intracellular
comment: Reactome DB_ID: 4230006

http://identifiers.org/pubmed/17397399
type: PublicationXref
id: 17397399
author: Kikuchi, Akira
author: Komekado, Hideyuki
author: Chiba, Tsutomu
author: Yamamoto, Hideki
db: Pubmed
title: Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a
source: Genes Cells 12:521-34
year: 2007

P63740
type: Protein
entity reference: UniProt:P63740
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Aspartate carbamoyltransferase
name: Dihydroorotase
name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
name: CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3))
name: Glutamine-dependent carbamoyl-phosphate synthase
xref: UnificationXref1124
feature: FragmentFeature80
cellular location: intracellular
comment: Reactome DB_ID: 4230100
display name: CAD

http://identifiers.org/pubmed/18641646
type: PublicationXref
id: 18641646
author: Van der Veen, AG
author: Ploegh, HL
author: Vyas, JM
db: Pubmed
title: The known unknowns of antigen processing and presentation
source: Nat Rev Immunol 8:607-18
year: 2008

http://identifiers.org/pubmed/18288277
type: PublicationXref
id: 18288277
author: Kersten, S
db: Pubmed
title: Peroxisome proliferator activated receptors and lipoprotein metabolism
source: PPAR Res 2008:132960
year: 2008

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P67062
data source: Reactome
name: COQ5_HUMAN
name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial ecNumber2.1.1.201/ecNumber
name: P67062
xref: UnificationXref709
feature: FragmentFeature48
cellular location: intracellular
comment: Reactome DB_ID: 4231195
display name: COQ5

Q7A5J3
type: Protein
entity reference: UniProt:Q7A5J3
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Decaprenyl-diphosphate synthase subunit 1 ecNumber2.5.1.91/ecNumber
name: DPS1_HUMAN
xref: UnificationXref689
feature: FragmentFeature47
cellular location: intracellular
comment: Reactome DB_ID: 4231201
display name: PDSS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A093
data source: Reactome
name: 2xPalmC-MyrG-NOS3
name: palmitylated, N-myristoylated eNOS
name: 2xPalmC-MyrG-NOS3(2-1203)
xref: UnificationXref728
feature: FragmentFeature50
feature: ModificationFeature4
feature: ModificationFeature6
feature: ModificationFeature5
cellular location: intracellular
comment: Reactome DB_ID: 4230609
display name: P0A093

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A093
data source: Reactome
name: MyrG-NOS3
name: MyrG-NOS3(2-1203)
name: N-myristoylated eNOS (Gly2)
xref: UnificationXref724
feature: FragmentFeature49
feature: ModificationFeature4
cellular location: intracellular
comment: Reactome DB_ID: 4230602
display name: P0A093

Q7A5J3
type: Protein
entity reference: UniProt:Q7A5J3
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Decaprenyl-diphosphate synthase subunit 2 ecNumber2.5.1.91/ecNumber
name: DLP1_HUMAN
xref: UnificationXref686
feature: FragmentFeature46
cellular location: intracellular
comment: Reactome DB_ID: 4231203
display name: PDSS2

RelationshipXref171
type: RelationshipXref
id: GO:0004088
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P65256
data source: Reactome
name: LDH muscle subunit
name: P65256
name: lactate dehydrogenase A
name: L-lactate dehydrogenase A chain
name: LDH-A
name: LDH-M
xref: UnificationXref775
feature: FragmentFeature54
cellular location: intracellular
comment: Reactome DB_ID: 4229821
display name: LDHA

RelationshipXref170
type: RelationshipXref
id: GO:0006144
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref173
type: RelationshipXref
id: GO:0004070
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref172
type: RelationshipXref
id: 4230107
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230107

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P99079
data source: Reactome
name: Dihydrofolate reductase
name: DYR_HUMAN
name: P99079
xref: UnificationXref756
feature: FragmentFeature52
cellular location: intracellular
comment: Reactome DB_ID: 4230551
display name: DHFR

UnificationXref1826
type: UnificationXref
id: 374061
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=374061

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A093
data source: Reactome
name: 2xPalmC-MyrG-NOS3
name: palmitylated, N-myristoylated eNOS
name: 2xPalmC-MyrG-NOS3(2-1203)
xref: UnificationXref740
feature: FragmentFeature51
feature: ModificationFeature4
feature: ModificationFeature6
feature: ModificationFeature5
cellular location: plasma membrane
comment: Reactome DB_ID: 4230607
display name: P0A093

UnificationXref1827
type: UnificationXref
id: REACT_21729
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21729.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99119
data source: Reactome
name: LDH muscle subunit
name: lactate dehydrogenase A
name: L-lactate dehydrogenase A chain
name: LDH-A
name: P99119
name: LDH-M
xref: UnificationXref773
feature: FragmentFeature53
cellular location: intracellular
comment: Reactome DB_ID: 4229818
display name: LDHA

UnificationXref1828
type: UnificationXref
id: 4230977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230977

Homologues of LDHA
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref776
cellular location: intracellular
comment: Reactome DB_ID: 4229822
comment: Converted from EntitySet in Reactome

UnificationXref1829
type: UnificationXref
id: 4230978
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230978

RelationshipXref167
type: RelationshipXref
id: GO:0004096
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1823
type: UnificationXref
id: REACT_99109
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99109.9

RelationshipXref168
type: RelationshipXref
id: 4230258
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230258

UnificationXref1822
type: UnificationXref
id: 4229860
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229860

RelationshipXref169
type: RelationshipXref
id: GO:0006195
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref1825
type: UnificationXref
id: REACT_15639
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15639.2

UnificationXref1824
type: UnificationXref
id: 374064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=374064

RelationshipXref163
type: RelationshipXref
id: GO:0043101
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref164
type: RelationshipXref
id: GO:0008253
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref165
type: RelationshipXref
id: 4230274
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230274

UnificationXref1821
type: UnificationXref
id: 4229858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229858

RelationshipXref166
type: RelationshipXref
id: 4230045
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230045

UnificationXref1820
type: UnificationXref
id: 4229857
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229857

THF-polyglutamate
type: SmallMoleculeReference
name: Tetrahydrofolyl-[Glu](n)
name: Tetrahydrofolyl-[Glu](n) [ChEBI:9484]
name: Tetrahydrofolyl-[Glu](n+1)
xref: UnificationXref1503

P99151
type: Protein
entity reference: P99151
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: NAD
name: nicotinamide nucleotide transhydrogenase
xref: UnificationXref810
feature: FragmentFeature58
cellular location: intracellular
comment: Reactome DB_ID: 4230968
display name: NNT

Homologues of NNT
type: Protein
data source: Reactome
member physical entity: P99151
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref813
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230972

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A561
data source: Reactome
name: Citrate synthase, mitochondrial precursor
name: Q7A561
name: citrate synthase
xref: UnificationXref797
feature: FragmentFeature57
cellular location: intracellular
comment: Reactome DB_ID: 4229955
display name: CS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P65256
data source: Reactome
name: LDH-H
name: lactate dehydrogenase B
name: P65256
name: L-lactate dehydrogenase B chain
name: LDH-B
name: LDH heart subunit
xref: UnificationXref778
feature: FragmentFeature56
cellular location: intracellular
comment: Reactome DB_ID: 4229824
display name: LDHB

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99119
data source: Reactome
name: LDH-H
name: lactate dehydrogenase B
name: L-lactate dehydrogenase B chain
name: LDH-B
name: P99119
name: LDH heart subunit
xref: UnificationXref777
feature: FragmentFeature55
cellular location: intracellular
comment: Reactome DB_ID: 4229823
display name: LDHB

Homologues of LDHB
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref779
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4229825

RelationshipXref184
type: RelationshipXref
id: 4230120
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230120

RelationshipXref183
type: RelationshipXref
id: GO:0004132
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref182
type: RelationshipXref
id: 4230089
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230089

UnificationXref1819
type: UnificationXref
id: P60088
db: UniProt

RelationshipXref181
type: RelationshipXref
id: GO:0004590
db: GENE ONTOLOGY
relationship type: MI:0355

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99U74
data source: Reactome
name: 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor
name: Q99U74
name: 2-oxoglutarate dehydrogenase E1
name: ODO1_HUMAN
name: Alpha-ketoglutarate dehydrogenase
name: alpha-ketoglutarate dehydrogenase E1 apoenzyme
xref: UnificationXref835
feature: FragmentFeature62
cellular location: intracellular
comment: Reactome DB_ID: 4229967
display name: OGDH

RelationshipXref180
type: RelationshipXref
id: 4230091
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230091

UnificationXref1817
type: UnificationXref
id: 29514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29514

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5N4
data source: Reactome
name: alpha-ketoglutarate dehydrogenase E2
name: Q7A5N4
name: Dihydrolipoamide succinyltransferase
name: Lipo-DLST
xref: UnificationXref829
feature: FragmentFeature61
feature: ModificationFeature7
cellular location: intracellular
comment: Reactome DB_ID: 4229973
display name: DLST

UnificationXref1818
type: UnificationXref
id: REACT_2669
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2669.1

Glycine cleavage system L protein
type: Protein
entity reference: UniProt:P99084
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: P99084
name: Dihydrolipoamide dehydrogenase, mitochondrial
xref: UnificationXref824
feature: FragmentFeature60
cellular location: intracellular
comment: Reactome DB_ID: 4229915
display name: DLD

UnificationXref1815
type: UnificationXref
id: REACT_5017
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5017.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99TF4
data source: Reactome
name: NAD
name: nicotinamide nucleotide transhydrogenase
name: Q99TF4
xref: UnificationXref812
feature: FragmentFeature59
cellular location: intracellular
comment: Reactome DB_ID: 4230971
display name: NNT

UnificationXref1816
type: UnificationXref
id: CHEBI:16199
db: ChEBI

http://identifiers.org/pubmed/2925663
type: PublicationXref
id: 2925663
author: Ambroziak, W
author: Pietruszko, R
author: Kurys, G
db: Pubmed
title: Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde.
source: J Biol Chem 264:4715-21
year: 1989

UnificationXref1814
type: UnificationXref
id: 29498
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29498

UnificationXref1813
type: UnificationXref
id: REACT_113182
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113182.8

RelationshipXref178
type: RelationshipXref
id: 4230097
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230097

UnificationXref1812
type: UnificationXref
id: 4229866
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229866

http://identifiers.org/pubmed/12832624
type: PublicationXref
id: 12832624
author: Hoffmeister, M
author: Theissen, U
author: Grieshaber, M
author: Martin, W
db: Pubmed
title: Single eubacterial origin of eukaryotic sulfide:quinone oxidoreductase, a mitochondrial enzyme conserved from the early evolution of eukaryotes during anoxic and sulfidic times
source: Mol Biol Evol 20:1564-74
year: 2003

RelationshipXref179
type: RelationshipXref
id: GO:0004588
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1811
type: UnificationXref
id: 4229864
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229864

RelationshipXref176
type: RelationshipXref
id: 4230103
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230103

UnificationXref1810
type: UnificationXref
id: 4229863
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229863

RelationshipXref177
type: RelationshipXref
id: GO:0004152
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref174
type: RelationshipXref
id: 4230105
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230105

RelationshipXref175
type: RelationshipXref
id: GO:0004151
db: GENE ONTOLOGY
relationship type: MI:0355

Hydroxymethylglutaryl-CoA synthase
type: Protein
entity reference: Q7A3F6
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7A3F6
xref: UnificationXref439
feature: FragmentFeature29
cellular location: intracellular
comment: Reactome DB_ID: 4230488
display name: HMGCS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A756
data source: Reactome
name: MVD(2-400)
name: Diphosphomevalonate decarboxylase
xref: UnificationXref460
feature: FragmentFeature31
cellular location: intracellular
comment: Reactome DB_ID: 4230499
display name: Q7A756

http://identifiers.org/pubmed/15450248
type: PublicationXref
id: 15450248
author: Shi, Q
author: Huang, S
author: Wei, D
author: Xie, K
db: Pubmed
title: Constitutive and inducible expression and regulation of vascular endothelial growth factor
source: Cytokine Growth Factor Rev 15:297-324
year: 2004

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A757
data source: Reactome
name: Mevalonate kinase
name: Q7A757
xref: UnificationXref449
feature: FragmentFeature30
cellular location: intracellular
comment: Reactome DB_ID: 4230493
display name: MVK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A710
data source: Reactome
name: Phosphorylethanolamine transferase
name: Ethanolamine-phosphate cytidylyltransferase
name: Q7A710
xref: UnificationXref494
feature: FragmentFeature33
cellular location: intracellular
comment: Reactome DB_ID: 4231121
display name: PCYT2

UnificationXref1804
type: UnificationXref
id: P63645
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5G9
data source: Reactome
name: HSD11B1
name: Corticosteroid 11-beta-dehydrogenase, isozyme 1
xref: UnificationXref473
feature: FragmentFeature32
cellular location: intracellular
comment: Reactome DB_ID: 4230515
display name: Q7A5G9

UnificationXref1805
type: UnificationXref
id: 4229869
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229869

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A710
data source: Reactome
name: CCT-alpha
name: Choline-phosphate cytidylyltransferase A
name: Q7A710
xref: UnificationXref522
feature: FragmentFeature35
cellular location: intracellular
comment: Reactome DB_ID: 4231114
display name: PCYT1A

RelationshipXref191
type: RelationshipXref
id: 4230126
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230126

UnificationXref1806
type: UnificationXref
id: 4229870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229870

Q7A3P6
type: Protein
entity reference: Q7A3P6
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Acetylcholinesterase
xref: UnificationXref510
feature: FragmentFeature34
cellular location: plasma membrane
comment: Reactome DB_ID: 4230662
display name: ACHE

RelationshipXref190
type: RelationshipXref
id: GO:0019206
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref1807
type: UnificationXref
id: 4229872
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229872

Q7A3C6
type: Protein
entity reference: Q7A3C6
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Carbonyl reductase (NADPH)1
name: CBR1_HUMAN
xref: UnificationXref554
feature: FragmentFeature37
cellular location: intracellular
comment: Reactome DB_ID: 4231167
display name: CBR1

RelationshipXref193
type: RelationshipXref
id: 4230144
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230144

UnificationXref1808
type: UnificationXref
id: REACT_99835
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99835.9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A710
data source: Reactome
name: Choline-phosphate cytidylyltransferase B
name: Phosphorylcholine transferase B
name: PCYT1B
name: Q7A710
xref: UnificationXref524
feature: FragmentFeature36
cellular location: intracellular
comment: Reactome DB_ID: 4231116
display name: CCTB

RelationshipXref192
type: RelationshipXref
id: 4230305
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230305

UnificationXref1809
type: UnificationXref
id: P63583
db: UniProt

RelationshipXref195
type: RelationshipXref
id: 4230138
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230138

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A492
data source: Reactome
name: Prostaglandin reductase 1
name: PTGR1_HUMAN
name: Q7A492
xref: UnificationXref574
feature: FragmentFeature38
cellular location: intracellular
comment: Reactome DB_ID: 4231162
display name: PTGR1

RelationshipXref194
type: RelationshipXref
id: GO:0004126
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref185
type: RelationshipXref
id: GO:0004799
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref186
type: RelationshipXref
id: 4230132
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230132

RelationshipXref187
type: RelationshipXref
id: GO:0046134
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref188
type: RelationshipXref
id: GO:0016763
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref189
type: RelationshipXref
id: 4230391
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230391

UnificationXref1801
type: UnificationXref
id: CHEBI:15682
db: ChEBI

UnificationXref1800
type: UnificationXref
id: REACT_78698
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78698.9

UnificationXref1803
type: UnificationXref
id: REACT_5577
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5577.1

UnificationXref1802
type: UnificationXref
id: 34575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=34575

http://identifiers.org/pubmed/8163052
type: PublicationXref
id: 8163052
author: Gomis, R
author: Malaisse, WJ
author: Sener, A
author: Fernandez-Alvarez, J
author: Conget, I
author: Rasschaert, J
db: Pubmed
title: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
source: Diabetologia 37:177-81
year: 1994

http://identifiers.org/pubmed/4748759
type: PublicationXref
id: 4748759
author: Hopkinson, DA
author: Harris, H
author: Smith, M
db: Pubmed
title: Studies on the subunit structure and molecular size of the human alcohol dehydrogenase isozymes determined by the different loci, ADH1, ADH2, and ADH3.
source: Ann Hum Genet 36:401-14
year: 1974

http://identifiers.org/pubmed/15105273
type: PublicationXref
id: 15105273
author: Westaway, SK
author: Johnson, MA
author: Parker, SM
author: Hayflick, SJ
author: Gitschier, J
author: Ching, KH
author: Kuo, YM
db: Pubmed
title: Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration
source: Ann N Y Acad Sci 1012:282-98
year: 2004

Platelet homeostasis
type: Pathway
data source: Reactome
pathway component: Nitric oxide stimulates guanylate cyclase
evidence: Evidence3
xref: UnificationXref32
xref: UnificationXref33
pathway order: PathwayStep2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Metabolism of nucleotides
type: Pathway
data source: Reactome
pathway component: Synthesis and interconversion of nucleotide di- and triphosphates
pathway component: REACT 93010.9
pathway component: BiochemicalReaction106
pathway component: BiochemicalReaction105
pathway component: Pyrimidine metabolism
pathway component: BiochemicalReaction107
evidence: Evidence174
xref: RelationshipXref211
xref: UnificationXref1413
xref: UnificationXref1412
pathway order: PathwayStep160
pathway order: PathwayStep170
pathway order: PathwayStep169
pathway order: PathwayStep167
pathway order: PathwayStep168
pathway order: PathwayStep141
display name: Nucleotide metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Homologues of GPX4(?-197)
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref610
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231178

http://identifiers.org/pubmed/9461497
type: PublicationXref
id: 9461497
author: Zhang, H
author: Tai, HH
author: Ensor, CM
db: Pubmed
title: Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
source: Biochem J 330:103-8
year: 1998

L-selenocysteine residue-GPX1
type: Protein
entity reference: P99097
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Cellular glutathione peroxidase
name: GSHC_HUMAN
name: GSHPx-1
name: P99097
name: glutathione peroxidase monomer
name: Glutathione peroxidase 1
xref: UnificationXref605
feature: ModificationFeature3
feature: FragmentFeature40
cellular location: intracellular
comment: Reactome DB_ID: 4230042
display name: GPX1

L-selenocysteine residue-GPX1
type: Protein
entity reference: Q7A391
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Cellular glutathione peroxidase
name: GSHC_HUMAN
name: GSHPx-1
name: glutathione peroxidase monomer
name: Q7A391
name: Glutathione peroxidase 1
xref: UnificationXref603
feature: ModificationFeature2
feature: FragmentFeature39
cellular location: intracellular
comment: Reactome DB_ID: 4230038
display name: GPX1

Homologues of L-selenocysteine residue-GPX1
type: Protein
data source: Reactome
member physical entity: L-selenocysteine residue-GPX1
xref: UnificationXref606
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230043

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A391
data source: Reactome
name: GPX2_HUMAN
name: Q7A391
name: Glutathione peroxidase 2
xref: UnificationXref622
feature: FragmentFeature43
cellular location: intracellular
comment: Reactome DB_ID: 4231172
display name: GPX2

Homologues of GPX2
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref624
cellular location: intracellular
comment: Reactome DB_ID: 4231174
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99097
data source: Reactome
name: GPX4(?-197)
name: P99097
name: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
name: GPX4_HUMAN
xref: UnificationXref609
feature: FragmentFeature42
cellular location: intracellular
comment: Reactome DB_ID: 4231177
display name: GPX4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A391
data source: Reactome
name: GPX4(?-197)
name: Q7A391
name: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
name: GPX4_HUMAN
xref: UnificationXref608
feature: FragmentFeature41
cellular location: intracellular
comment: Reactome DB_ID: 4231176
display name: GPX4

Serine biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction132
evidence: Evidence209
xref: UnificationXref1628
xref: UnificationXref1629
xref: RelationshipXref254
pathway order: PathwayStep205
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5G9
data source: Reactome
name: Q7A5G9
name: 3-ketodihydrosphingosine reductase
xref: UnificationXref668
feature: FragmentFeature45
cellular location: intracellular
comment: Reactome DB_ID: 4230856
display name: KDSR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99097
data source: Reactome
name: GPX2_HUMAN
name: P99097
name: Glutathione peroxidase 2
xref: UnificationXref623
feature: FragmentFeature44
cellular location: intracellular
comment: Reactome DB_ID: 4231173
display name: GPX2

Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction62
pathway component: BiochemicalReaction61
evidence: Evidence117
xref: RelationshipXref130
xref: UnificationXref875
xref: UnificationXref874
pathway order: PathwayStep112
pathway order: PathwayStep113
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref198
type: RelationshipXref
id: GO:0006206
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref199
type: RelationshipXref
id: GO:0004385
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref196
type: RelationshipXref
id: GO:0043097
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref197
type: RelationshipXref
id: GO:0046135
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/14990995
type: PublicationXref
id: 14990995
author: Yoshida, K
author: Inoue, I
db: Pubmed
title: Regulation of Geminin and Cdt1 expression by E2F transcription factors
source: Oncogene 23:3802-12
year: 2004

3-Methyl-2-oxopentanoate
type: SmallMoleculeReference
name: 2-Oxo-3-methylvalerate
name: 3-Methyl-2-oxopentanoate [ChEBI:28654]
xref: UnificationXref1635

http://identifiers.org/pubmed/8366112
type: PublicationXref
id: 8366112
author: Stone, RL
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase
source: J Biol Chem 268:19710-19716
year: 1993

http://identifiers.org/pubmed/21111842
type: PublicationXref
id: 21111842
author: Kefalov, Vladimir J
author: Wang, Jin-Shan
db: Pubmed
title: The cone-specific visual cycle
source: Prog Retin Eye Res 30:115-28
year: 2011

UnificationXref3099
type: UnificationXref
id: 4230318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230318

UnificationXref3098
type: UnificationXref
id: 4230317
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230317

UnificationXref3097
type: UnificationXref
id: 4230316
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230316

UnificationXref1730
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction53
evidence: Evidence103
xref: UnificationXref760
xref: UnificationXref761
pathway order: PathwayStep99
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1731
type: UnificationXref
id: 29506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29506

UnificationXref1732
type: UnificationXref
id: REACT_2616
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2616.2

UnificationXref1733
type: UnificationXref
id: 29406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29406

UnificationXref1734
type: UnificationXref
id: REACT_5182
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5182.4

UnificationXref1735
type: UnificationXref
id: CHEBI:15999
db: ChEBI

UnificationXref1736
type: UnificationXref
id: 31365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31365

http://identifiers.org/pubmed/12482742
type: PublicationXref
id: 12482742
author: Busse, R
author: Fleming, I
db: Pubmed
title: Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
source: Am J Physiol Regul Integr Comp Physiol 284:R1-12
year: 2003

UnificationXref1737
type: UnificationXref
id: REACT_2627
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2627.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5Z7
data source: Reactome
name: Ribulose-phosphate 3-epimerase
name: Ribulose-5-phosphate-3- epimerase
name: HUSSY-17
name: ribulose phosphate 3-epimerase
name: ribulose-5-phosphate epimerase
name: phosphopentose isomerase
name: Q7A5Z7
xref: UnificationXref266
feature: FragmentFeature21
cellular location: intracellular
comment: Reactome DB_ID: 4230011
display name: RPE

UnificationXref1739
type: UnificationXref
id: 4229987
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229987

P66695
type: Protein
entity reference: P66695
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: RPIA(1-237)
name: ribose 5-phosphate isomerase
xref: UnificationXref276
feature: FragmentFeature22
cellular location: intracellular
comment: Reactome DB_ID: 4230017
display name: RPIA

UnificationXref1738
type: UnificationXref
id: Q7A6A5
db: UniProt

P65237
type: Protein
entity reference: P65237
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribose-phosphate pyrophosphokinase I
name: PPRibP
name: phosphoribosyl pyrophosphate synthetase 1
name: PRS-I
name: Phosphoribosyl pyrophosphate synthetase I
name: Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PPRibP) (PRS-I)
xref: UnificationXref293
feature: FragmentFeature23
cellular location: intracellular
comment: Reactome DB_ID: 4230111
display name: PRPS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3P6
data source: Reactome
name: CEL(21-742)
name: bile salt-dependent lipase
name: CEL monomer
xref: UnificationXref339
feature: FragmentFeature24
cellular location: extracellular region
comment: Reactome DB_ID: 4230505
display name: Q7A3P6

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99113
data source: Reactome
name: ATP:glycerol 3-phosphotransferase
name: P99113
name: Glycerokinase
name: Glycerol kinase
xref: UnificationXref370
feature: FragmentFeature25
cellular location: intracellular
comment: Reactome DB_ID: 4230249
display name: GK

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3F6
data source: Reactome
name: Q7A3F6
name: hydroxymethylglutaryl-CoA synthase
name: Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor
name: 3-hydroxy-3-methylglutaryl coenzyme A synthase
name: HMG-CoA synthase
xref: UnificationXref385
feature: FragmentFeature26
cellular location: intracellular
comment: Reactome DB_ID: 4230225
display name: HMGCS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5V7
data source: Reactome
name: Q7A5V7
xref: UnificationXref403
feature: FragmentFeature27
cellular location: intracellular
comment: Reactome DB_ID: 4230450
display name: GPD2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7X1
data source: Reactome
name: 3-ketoacyl-CoA thiolase, peroxisomal
name: Q7A7X1
name: Acetyl-Coenzyme A acyltransferase 1
xref: UnificationXref426
feature: FragmentFeature28
cellular location: intracellular
comment: Reactome DB_ID: 4230775
display name: ACAA1

Q7A5G7
type: Protein
entity reference: UniProt:Q7A5G7
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Glucose-6-phosphate 1-dehydrogenase
xref: UnificationXref243
feature: FragmentFeature19
cellular location: intracellular
comment: Reactome DB_ID: 4229760
display name: G6PD

http://identifiers.org/pubmed/6434529
type: PublicationXref
id: 6434529
author: Chuang, DT
author: Cox, RP
author: Markovitz, PJ
db: Pubmed
title: Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
source: J Biol Chem 259:11643-6
year: 1984

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P63334
data source: Reactome
name: 6-phosphogluconate dehydrogenase, decarboxylating
name: phosphogluconate dehydrogenase
name: P63334
name: 6-phosphogluconate 2-dehydrogenase
name: PGD(2-483)
xref: UnificationXref258
feature: FragmentFeature20
cellular location: intracellular
comment: Reactome DB_ID: 4230005
display name: PGD

http://identifiers.org/pubmed/15071553
type: PublicationXref
id: 15071553
author: Kühlbrandt, W
db: Pubmed
title: Biology, structure and mechanism of P-type ATPases
source: Nat Rev Mol Cell Biol 5:282-95
year: 2004

UnificationXref1740
type: UnificationXref
id: 4229988
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229988

UnificationXref1743
type: UnificationXref
id: 4231007
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231007

UnificationXref1744
type: UnificationXref
id: REACT_125748
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125748.5

UnificationXref1741
type: UnificationXref
id: 4229990
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229990

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A859
data source: Reactome
name: UDP- galactose 4-epimerase
name: UDP-galactose 4-epimerase
name: UDP-glucose 4-epimerase
name: UDP-galactose 4-epimerase apoenzyme
name: GALE_HUMAN
name: Q7A859
name: Galactowaldenase
xref: UnificationXref230
feature: FragmentFeature18
cellular location: intracellular
comment: Reactome DB_ID: 4229754
display name: GALE

UnificationXref1742
type: UnificationXref
id: REACT_28499
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28499.10

UnificationXref1747
type: UnificationXref
id: P99076
db: UniProt

UnificationXref1748
type: UnificationXref
id: 4229888
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229888

UnificationXref1745
type: UnificationXref
id: 4231271
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231271

UnificationXref1746
type: UnificationXref
id: REACT_88002
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88002.9

P99133
type: Protein
entity reference: P99133
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: triosephosphate isomerase monomer
name: TPI1
name: TPIS_HUMAN
name: Triosephosphate isomerase
xref: UnificationXref112
feature: FragmentFeature12
cellular location: intracellular
comment: Reactome DB_ID: 4229768
display name: TIM

Methylation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction161
evidence: Evidence283
xref: RelationshipXref354
xref: UnificationXref2168
xref: UnificationXref2169
pathway order: PathwayStep250
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

PRP 2
type: Protein
entity reference: P99135
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: P99135
name: Phosphoglycerate kinase 1
name: Primer recognition protein 2
xref: UnificationXref126
feature: FragmentFeature13
cellular location: intracellular
comment: Reactome DB_ID: 4229799
display name: PGK1

PFK-B
type: Protein
entity reference: P99165
data source: Reactome
name: 6-phosphofructokinase, liver type
name: Note: the coordinates are copied over from Homo sapiens.
name: Phosphohexokinase
name: Phosphofructokinase 1
name: P99165
name: Phosphofructo-1-kinase isozyme B
xref: UnificationXref84
feature: FragmentFeature10
cellular location: intracellular
comment: Reactome DB_ID: 4229774
display name: PFKL

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99165
data source: Reactome
name: PFK-C
name: Phosphohexokinase
name: Phosphofructokinase 1
name: 6-phosphofructokinase, isozyme C
name: P99165
name: Phosphofructo-1-kinase isozyme C
name: 6-phosphofructokinase, type C
name: 6-phosphofructokinase, platelet type
name: K6PP_HUMAN
xref: UnificationXref86
feature: FragmentFeature11
cellular location: intracellular
comment: Reactome DB_ID: 4229776
display name: PFKP

UnificationXref1749
type: UnificationXref
id: 4229889
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229889

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A666
data source: Reactome
name: Pyruvic carboxylase
name: Pyruvate carboxylase, mitochondrial precursor
name: Q7A666
name: pyruvate carboxylase
xref: UnificationXref188
feature: FragmentFeature16
cellular location: intracellular
comment: Reactome DB_ID: 4229811
display name: PC

phospho-p-S33-PFKFB1(1-471)
type: Protein
entity reference: Q7A7J4
data source: Reactome
xref: UnificationXref210
feature: FragmentFeature17
feature: ModificationFeature1
cellular location: intracellular
comment: Reactome DB_ID: 4229748

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P99088
data source: Reactome
name: 2-phospho-D-glycerate hydro-lyase
name: Alpha enolase
name: P99088
name: Phosphopyruvate hydratase
name: Enolase 1
name: Non- neural enolase
name: enolase 1, (alpha)
name: ENO1
xref: UnificationXref140
feature: FragmentFeature14
cellular location: intracellular
comment: Reactome DB_ID: 4229805
display name: NNE

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A559
data source: Reactome
name: PKM isozyme M1
name: Q7A559
name: pyruvate kinase, M1 isozyme
name: PKM isoform 2
xref: UnificationXref147
feature: FragmentFeature15
cellular location: intracellular
comment: Reactome DB_ID: 4230024
display name: PKM-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7J4
data source: Reactome
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
name: Fructose-2,6-bisphosphatase
name: 6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme
name: Q7A7J4
name: 6-phosphofructo-2-kinase
xref: UnificationXref74
feature: FragmentFeature9
cellular location: intracellular
comment: Reactome DB_ID: 4230071
display name: PFKFB4

UnificationXref1712
type: UnificationXref
id: REACT_113111
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113111.8

UnificationXref1713
type: UnificationXref
id: 4231006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231006

UnificationXref1714
type: UnificationXref
id: REACT_136327
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136327.5

UnificationXref1715
type: UnificationXref
id: CHEBI:15524
db: ChEBI

UnificationXref1710
type: UnificationXref
id: 4229950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229950

UnificationXref1711
type: UnificationXref
id: 4229952
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229952

UnificationXref1717
type: UnificationXref
id: REACT_2558
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2558.2

UnificationXref1716
type: UnificationXref
id: 70955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70955

UnificationXref1719
type: UnificationXref
id: REACT_93348
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93348.9

UnificationXref1718
type: UnificationXref
id: 4229977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229977

UnificationXref1725
type: UnificationXref
id: 4229981
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229981

UnificationXref1726
type: UnificationXref
id: 4229983
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229983

UnificationXref1723
type: UnificationXref
id: Q99WZ0
db: UniProt

UnificationXref1724
type: UnificationXref
id: 4229980
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229980

UnificationXref1721
type: UnificationXref
id: 71045
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71045

UnificationXref1722
type: UnificationXref
id: REACT_3284
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3284.1

UnificationXref1720
type: UnificationXref
id: CHEBI:15473
db: ChEBI

UnificationXref1729
type: UnificationXref
id: REACT_78200
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78200.9

UnificationXref1728
type: UnificationXref
id: 4231269
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231269

UnificationXref1727
type: UnificationXref
id: REACT_108443
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108443.9

http://identifiers.org/pubmed/10843999
type: PublicationXref
id: 10843999
author: Hannah, VC
author: Luong, A
author: Goldstein, JL
db: Pubmed
title: Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
source: J Biol Chem 275:26458-66
year: 2000

UnificationXref1775
type: UnificationXref
id: 113561
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113561

UnificationXref1774
type: UnificationXref
id: REACT_94354
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94354.9

UnificationXref1777
type: UnificationXref
id: 29896
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29896

UnificationXref1776
type: UnificationXref
id: REACT_3412
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3412.1

UnificationXref1779
type: UnificationXref
id: 29676
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29676

UnificationXref1778
type: UnificationXref
id: REACT_2670
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2670.1

UnificationXref3059
type: UnificationXref
id: 4230354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230354

UnificationXref3057
type: UnificationXref
id: 4230352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230352

UnificationXref3058
type: UnificationXref
id: 4230353
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230353

UnificationXref3055
type: UnificationXref
id: 4230351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230351

UnificationXref1771
type: UnificationXref
id: 4231026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231026

UnificationXref3056
type: UnificationXref
id: REACT_78971
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78971.9

UnificationXref1770
type: UnificationXref
id: REACT_25814
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25814.1

UnificationXref3053
type: UnificationXref
id: 4230349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230349

UnificationXref1773
type: UnificationXref
id: 4231272
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231272

UnificationXref3054
type: UnificationXref
id: 4230350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230350

UnificationXref1772
type: UnificationXref
id: REACT_142392
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142392.5

UnificationXref3063
type: UnificationXref
id: 4230339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230339

UnificationXref3062
type: UnificationXref
id: Q7A4T1
db: UniProt

UnificationXref3061
type: UnificationXref
id: 4230340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230340

UnificationXref3060
type: UnificationXref
id: REACT_99264
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99264.9

http://identifiers.org/pubmed/1460020
type: PublicationXref
id: 1460020
author: Marshall, S
author: Traxinger, RR
author: Sheppard, PO
author: O'Hara, PJ
author: Mathewes, SL
author: Mudri, SL
author: McKnight, GL
db: Pubmed
title: Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase
source: J Biol Chem 267:25208-12
year: 1992

UnificationXref1788
type: UnificationXref
id: 4229843
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229843

UnificationXref1787
type: UnificationXref
id: REACT_5708
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5708.2

UnificationXref1786
type: UnificationXref
id: 30471
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30471

UnificationXref1785
type: UnificationXref
id: CHEBI:17533
db: ChEBI

Unfolded Protein Response
type: Pathway
data source: Reactome
pathway component: REACT 146540.5
evidence: Evidence429
xref: UnificationXref3002
xref: UnificationXref3003
xref: RelationshipXref497
pathway order: PathwayStep418
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1789
type: UnificationXref
id: REACT_32408
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32408.10

UnificationXref3068
type: UnificationXref
id: REACT_86585
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86585.9

UnificationXref1780
type: UnificationXref
id: REACT_5535
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5535.2

http://identifiers.org/pubmed/11742412
type: PublicationXref
id: 11742412
author: Saltiel, AR
author: Kahn, CR
db: Pubmed
title: Insulin signalling and the regulation of glucose and lipid metabolism
source: Nature 414:799-806
year: 2001

UnificationXref3069
type: UnificationXref
id: CHEBI:44605
db: ChEBI

UnificationXref3064
type: UnificationXref
id: 4230341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230341

UnificationXref1784
type: UnificationXref
id: 4229842
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229842

UnificationXref3065
type: UnificationXref
id: 4230342
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230342

UnificationXref1783
type: UnificationXref
id: 4229840
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229840

UnificationXref3066
type: UnificationXref
id: REACT_104561
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104561.9

UnificationXref1782
type: UnificationXref
id: 4229839
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229839

UnificationXref3067
type: UnificationXref
id: 4231304
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231304

UnificationXref1781
type: UnificationXref
id: 4229836
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229836

UnificationXref3072
type: UnificationXref
id: 4230329
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230329

UnificationXref3071
type: UnificationXref
id: REACT_4681
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4681.2

UnificationXref3074
type: UnificationXref
id: 4230357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230357

UnificationXref3073
type: UnificationXref
id: 4230355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230355

UnificationXref3070
type: UnificationXref
id: 110242
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110242

http://identifiers.org/pubmed/7538665
type: PublicationXref
id: 7538665
author: Frigeri, A
author: Turck, CW
author: Gropper, MA
author: Verkman, AS
db: Pubmed
title: Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes
source: Proc Natl Acad Sci U S A 92:4328-31
year: 1995

UnificationXref1757
type: UnificationXref
id: CHEBI:15745
db: ChEBI

UnificationXref1756
type: UnificationXref
id: REACT_2656
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2656.2

UnificationXref1759
type: UnificationXref
id: REACT_3299
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3299.2

http://identifiers.org/pubmed/182209
type: PublicationXref
id: 182209
author: Fersht, AR
author: Kaethner, MM
db: Pubmed
title: Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing
source: Biochemistry 15:3342-6
year: 1976

UnificationXref1758
type: UnificationXref
id: 35181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=35181

http://identifiers.org/pubmed/12972261
type: PublicationXref
id: 12972261
author: Schneider, B
author: Janin, J
author: Chen, Y
author: Veron, M
author: Moréra, S
author: Deville-Bonne, D
author: Gallois-Montbrun, S
db: Pubmed
title: Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases
source: J Mol Biol 332:915-26
year: 2003

UnificationXref1753
type: UnificationXref
id: REACT_29511
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_29511.10

UnificationXref1752
type: UnificationXref
id: 4231265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231265

UnificationXref1755
type: UnificationXref
id: 36027
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=36027

UnificationXref1754
type: UnificationXref
id: CHEBI:29044
db: ChEBI

UnificationXref3077
type: UnificationXref
id: CHEBI:38635
db: ChEBI

UnificationXref3078
type: UnificationXref
id: 30947
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30947

UnificationXref3075
type: UnificationXref
id: REACT_94574
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94574.9

UnificationXref1751
type: UnificationXref
id: REACT_78368
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78368.9

UnificationXref3076
type: UnificationXref
id: 4230358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230358

UnificationXref1750
type: UnificationXref
id: 4229891
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229891

http://identifiers.org/pubmed/19379690
type: PublicationXref
id: 19379690
author: Kopan, R
author: Ilagan, Ma Xenia
db: Pubmed
title: The canonical Notch signaling pathway: unfolding the activation mechanism
source: Cell 137:216-33
year: 2009

UnificationXref3079
type: UnificationXref
id: REACT_4403
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4403.2

UnificationXref3081
type: UnificationXref
id: REACT_100545
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100545.9

UnificationXref3080
type: UnificationXref
id: 4230360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230360

UnificationXref3085
type: UnificationXref
id: 4230361
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230361

UnificationXref3084
type: UnificationXref
id: REACT_3185
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3185.2

UnificationXref3083
type: UnificationXref
id: 110249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110249

UnificationXref3082
type: UnificationXref
id: CHEBI:29146
db: ChEBI

UnificationXref1769
type: UnificationXref
id: 893617
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=893617

UnificationXref1768
type: UnificationXref
id: CHEBI:17442
db: ChEBI

Post-translational protein modification
type: Pathway
data source: Reactome
pathway component: REACT 139262.5
evidence: Evidence425
xref: UnificationXref2994
xref: UnificationXref2995
xref: RelationshipXref495
pathway order: PathwayStep414
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1767
type: UnificationXref
id: REACT_27004
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_27004.2

http://identifiers.org/pubmed/15274622
type: PublicationXref
id: 15274622
author: Kim, JJ
author: Wang, M
author: Fu, Z
author: Paschke, R
author: Frerman, FE
author: Rao, KS
db: Pubmed
title: Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
source: Biochemistry 43:9674-84
year: 2004

UnificationXref1766
type: UnificationXref
id: 893607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=893607

http://identifiers.org/pubmed/12669019
type: PublicationXref
id: 12669019
author: Desjardins, M
db: Pubmed
title: ER-mediated phagocytosis: a new membrane for new functions
source: Nat Rev Immunol 3:280-91
year: 2003

UnificationXref1765
type: UnificationXref
id: CHEBI:16946
db: ChEBI

UnificationXref1764
type: UnificationXref
id: REACT_106330
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_106330.9

UnificationXref1763
type: UnificationXref
id: 4229996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229996

UnificationXref3086
type: UnificationXref
id: REACT_89512
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89512.9

UnificationXref1762
type: UnificationXref
id: 4229994
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229994

UnificationXref3087
type: UnificationXref
id: 29850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29850

UnificationXref1761
type: UnificationXref
id: 4229993
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229993

UnificationXref3088
type: UnificationXref
id: REACT_3289
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3289.2

UnificationXref1760
type: UnificationXref
id: Q7A3C5
db: UniProt

UnificationXref3089
type: UnificationXref
id: 4230362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230362

UnificationXref3090
type: UnificationXref
id: REACT_96301
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96301.9

http://identifiers.org/pubmed/10600378
type: PublicationXref
id: 10600378
author: Tampé, R
author: Neumann, L
db: Pubmed
title: Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding
source: J Mol Biol 294:1203-13
year: 1999

UnificationXref3092
type: UnificationXref
id: REACT_78887
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78887.9

UnificationXref3091
type: UnificationXref
id: 4231306
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231306

UnificationXref3094
type: UnificationXref
id: REACT_78504
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78504.9

UnificationXref3093
type: UnificationXref
id: 4231305
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231305

http://identifiers.org/pubmed/6434534
type: PublicationXref
id: 6434534
author: Gracy, RW
author: Yuan, PM
author: Lu, HS
db: Pubmed
title: Primary structure of human triosephosphate isomerase
source: J Biol Chem 259:11958-68
year: 1984

UnificationXref3096
type: UnificationXref
id: 4230315
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230315

UnificationXref3095
type: UnificationXref
id: Q7A5K6
db: UniProt

http://identifiers.org/pubmed/15274629
type: PublicationXref
id: 15274629
author: Takeuchi, N
author: Heck, A
author: Spencer, AC
author: Watanabe, K
author: Spremulli, LL
db: Pubmed
title: Characterization of the human mitochondrial methionyl-tRNA synthetase
source: Biochemistry 43:9743-54
year: 2004

http://identifiers.org/pubmed/7354069
type: PublicationXref
id: 7354069
author: Anderson, PM
author: Desnick, RJ
db: Pubmed
title: Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
source: J Biol Chem 255:1993-9
year: 1980

UnificationXref3014
type: UnificationXref
id: 4231092
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231092

UnificationXref3013
type: UnificationXref
id: 4231090
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231090

UnificationXref3016
type: UnificationXref
id: 4231412
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231412

UnificationXref3015
type: UnificationXref
id: REACT_131635
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131635.5

UnificationXref3010
type: UnificationXref
id: Q7A708
db: UniProt

http://identifiers.org/pubmed/10229653
type: PublicationXref
id: 10229653
author: Wallace, JC
author: Jitrapakdee, S
db: Pubmed
title: Structure, function and regulation of pyruvate carboxylase
source: Biochem J 340:1-16
year: 1999

UnificationXref3012
type: UnificationXref
id: 4231088
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231088

UnificationXref3011
type: UnificationXref
id: 4231089
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231089

UnificationXref3018
type: UnificationXref
id: 4231416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231416

UnificationXref3017
type: UnificationXref
id: REACT_129197
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129197.5

UnificationXref3019
type: UnificationXref
id: REACT_145275
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145275.5

acetic acid, ion(1-)
type: SmallMoleculeReference
name: ethanoate
name: acetate
name: ACETATE ION
name: Ethanoat
name: CH3-COO(-)
name: Azetat
name: MeCO2 anion
name: acetate [ChEBI:30089]
xref: UnificationXref506

UnificationXref3030
type: UnificationXref
id: 4231015
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231015

http://identifiers.org/pubmed/7354072
type: PublicationXref
id: 7354072
author: Bodlaender, P
author: Shemin, D
author: Bevan, DR
db: Pubmed
title: Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity.
source: J Biol Chem 255:2030-5
year: 1980

Phase 1 - Functionalization of compounds
type: Pathway
data source: Reactome
pathway component: REACT 155651.3
evidence: Evidence274
xref: UnificationXref2099
xref: RelationshipXref347
xref: UnificationXref2098
pathway order: PathwayStep270
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref3027
type: UnificationXref
id: REACT_127366
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127366.5

UnificationXref3026
type: UnificationXref
id: 4231415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231415

UnificationXref3025
type: UnificationXref
id: REACT_127943
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127943.5

UnificationXref3024
type: UnificationXref
id: 4231414
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231414

UnificationXref3023
type: UnificationXref
id: REACT_127730
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127730.5

UnificationXref3022
type: UnificationXref
id: 4231413
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231413

UnificationXref3021
type: UnificationXref
id: REACT_143968
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143968.5

UnificationXref3020
type: UnificationXref
id: 4231417
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231417

http://identifiers.org/pubmed/11575290
type: PublicationXref
id: 11575290
author: Bell, GI
author: Fajans, SS
author: Polonsky, KS
db: Pubmed
title: Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
source: N Engl J Med 345:971-80
year: 2001

UnificationXref3029
type: UnificationXref
id: 4231014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231014

UnificationXref3028
type: UnificationXref
id: Q7A6T1
db: UniProt

UnificationXref3040
type: UnificationXref
id: REACT_140703
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140703.5

UnificationXref3041
type: UnificationXref
id: 4231404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231404

UnificationXref3032
type: UnificationXref
id: REACT_143071
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143071.5

UnificationXref1794
type: UnificationXref
id: 4229847
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229847

UnificationXref3031
type: UnificationXref
id: 4231016
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231016

UnificationXref1795
type: UnificationXref
id: P65602
db: UniProt

UnificationXref3034
type: UnificationXref
id: REACT_133418
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133418.5

UnificationXref1792
type: UnificationXref
id: REACT_2266
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2266.2

UnificationXref3033
type: UnificationXref
id: 4231401
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231401

UnificationXref1793
type: UnificationXref
id: P99073
db: UniProt

UnificationXref3036
type: UnificationXref
id: REACT_144584
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144584.5

UnificationXref1790
type: UnificationXref
id: 4229844
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229844

UnificationXref3035
type: UnificationXref
id: 4231406
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231406

UnificationXref1791
type: UnificationXref
id: 113567
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113567

UnificationXref3038
type: UnificationXref
id: REACT_127396
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127396.5

UnificationXref3037
type: UnificationXref
id: 4231402
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231402

UnificationXref3039
type: UnificationXref
id: 4231403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231403

UnificationXref1798
type: UnificationXref
id: 4229852
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229852

UnificationXref1799
type: UnificationXref
id: 4229854
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229854

UnificationXref1796
type: UnificationXref
id: 4229850
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229850

UnificationXref1797
type: UnificationXref
id: 4229851
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229851

2'-deoxyuridine 5'-triphosphate
type: SmallMoleculeReference
name: dUTP [ChEBI:17625]
name: dUTP
xref: UnificationXref1332

Protoheme
type: SmallMoleculeReference
name: Ferroheme
name: Heme
name: ChEBI:17627 Heme
name: Haem
xref: UnificationXref732

UnificationXref3051
type: UnificationXref
id: 4230348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230348

UnificationXref3052
type: UnificationXref
id: REACT_97570
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97570.9

UnificationXref3050
type: UnificationXref
id: 4230347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230347

UnificationXref3045
type: UnificationXref
id: 4231327
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231327

UnificationXref3044
type: UnificationXref
id: REACT_125867
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_125867.5

UnificationXref3043
type: UnificationXref
id: 4231405
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231405

UnificationXref3042
type: UnificationXref
id: REACT_131568
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131568.5

UnificationXref3049
type: UnificationXref
id: 4230345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230345

UnificationXref3048
type: UnificationXref
id: P65415
db: UniProt

UnificationXref3047
type: UnificationXref
id: 4230346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230346

UnificationXref3046
type: UnificationXref
id: REACT_147350
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147350.5

2'-Deoxyuridine 5'-phosphate
type: SmallMoleculeReference
name: Deoxyuridine monophosphate
name: dUMP
name: Deoxyuridylic acid
name: dUMP [ChEBI:17622]
name: Deoxyuridine 5'-phosphate
xref: UnificationXref1172

FMN [ChEBI:17621]
type: SmallMoleculeReference
name: FMN
name: Riboflavin-5-phosphate
name: Flavin mononucleotide
xref: UnificationXref735

http://identifiers.org/pubmed/14508490
type: PublicationXref
id: 14508490
author: Sacks, D
author: Goyette, G
author: Desjardins, M
author: Princiotta, MF
author: Brunet, S
author: Bertholet, S
author: Houde, M
author: Laplante, A
author: Thibault, P
author: Gagnon, E
db: Pubmed
title: Phagosomes are competent organelles for antigen cross-presentation
source: Nature 425:402-6
year: 2003

phenylacetyl-CoA [ChEBI:15537]
type: SmallMoleculeReference
name: phenylacetyl-CoA
xref: UnificationXref2187

Myristoyl-CoA
type: SmallMoleculeReference
name: Tetradecanoyl-CoA [ChEBI:15532]
name: Tetradecanoyl-CoA
xref: UnificationXref720

Carbamoyl phosphate [ChEBI:17672]
type: SmallMoleculeReference
name: Carbamoyl phosphate
xref: UnificationXref1118

cytidine 5'-triphosphate
type: SmallMoleculeReference
name: CTP [ChEBI:17677]
name: Cytidine triphosphate
name: CTP
xref: UnificationXref484

http://identifiers.org/pubmed/3327432
type: PublicationXref
id: 3327432
author: Kapoor, S
author: Seaman, C
author: Piomelli, S
db: Pubmed
title: Lead-induced abnormalities of porphyrin metabolism. The relationship with iron deficiency.
source: Ann N Y Acad Sci 514:278-88
year: 1987

http://identifiers.org/pubmed/14508489
type: PublicationXref
id: 14508489
author: Kleijmeer, M
author: Saveanu, L
author: Amigorena, S
author: Van Endert, P
author: Davoust, J
author: Guermonprez, P
db: Pubmed
title: ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
source: Nature 425:397-402
year: 2003

(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
type: SmallMoleculeReference
name: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate [ChEBI:247]
xref: UnificationXref557

Glycocholate [ChEBI:17687]
type: SmallMoleculeReference
name: Glycocholate
name: Glycocholic acid
xref: UnificationXref321

http://identifiers.org/pubmed/10331075
type: PublicationXref
id: 10331075
author: Szumlanski, CL
author: Otterness, DM
author: Weinshilboum, RM
db: Pubmed
title: Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
source: Annu Rev Pharmacol Toxicol 39:19-52
year: 1999

S-Benzoate coenzyme A
type: SmallMoleculeReference
name: S-Benzoate coenzyme A [ChEBI:15515]
name: Benzoyl-CoA
xref: UnificationXref2173

UDP
type: SmallMoleculeReference
name: uridine 5'-diphosphate
name: uridine 5'-diphosphate [ChEBI:17659]
xref: UnificationXref1303

Kendall's compound F
type: SmallMoleculeReference
name: Hydrocortisone
name: Cortisol
name: Cortisol [ChEBI:3893]
name: Reichstein's substance M
name: 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
xref: UnificationXref466

Glutaryl-CoA [ChEBI:15524]
type: SmallMoleculeReference
name: Glutaryl-CoA
xref: UnificationXref1715

alpha-D-Glucose 6-phosphate
type: SmallMoleculeReference
name: alpha-D-Glucose 6-phosphate [ChEBI:17665]
xref: UnificationXref47

UnificationXref3008
type: UnificationXref
id: 4231084
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231084

UnificationXref3009
type: UnificationXref
id: 4231085
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231085

UnificationXref3006
type: UnificationXref
id: 4231380
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231380

UnificationXref3007
type: UnificationXref
id: REACT_30134
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30134.10

UnificationXref3000
type: UnificationXref
id: 4231423
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231423

UnificationXref3001
type: UnificationXref
id: REACT_146540
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146540.5

UnificationXref3004
type: UnificationXref
id: 4231395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231395

UnificationXref3005
type: UnificationXref
id: REACT_138144
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_138144.5

UnificationXref3002
type: UnificationXref
id: 4231424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231424

UnificationXref3003
type: UnificationXref
id: REACT_131599
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131599.5

UnificationXref866
type: UnificationXref
id: 880041
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880041

UnificationXref865
type: UnificationXref
id: CHEBI:16724
db: ChEBI

UnificationXref864
type: UnificationXref
id: REACT_25542
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_25542.2

UnificationXref863
type: UnificationXref
id: 879997
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879997

Catalysis243
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction252
control type: ACTIVATION
xref: RelationshipXref474
xref: RelationshipXref468
controller: AQP7 tetramer (name copied from entity in Homo sapiens)

Catalysis242
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction251
control type: ACTIVATION
xref: RelationshipXref473
xref: RelationshipXref466
controller: AQP3 tetramer (name copied from entity in Homo sapiens)

UnificationXref869
type: UnificationXref
id: 4231021
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231021

Catalysis241
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction250
control type: ACTIVATION
xref: RelationshipXref471
xref: RelationshipXref470
controller: Aquaporin-9, Aquaporin-10

UnificationXref868
type: UnificationXref
id: Q7A843
db: UniProt

Catalysis240
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction249
control type: ACTIVATION
xref: RelationshipXref471
xref: RelationshipXref470
controller: Aquaporin-9, Aquaporin-10

UnificationXref867
type: UnificationXref
id: REACT_26786
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26786.2

Catalysis247
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction256
control type: ACTIVATION
xref: RelationshipXref483
xref: RelationshipXref484
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis246
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction255
control type: ACTIVATION
xref: RelationshipXref480
xref: RelationshipXref481
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis245
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction254
control type: ACTIVATION
xref: RelationshipXref478
xref: RelationshipXref479
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis244
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction253
control type: ACTIVATION
xref: RelationshipXref475
xref: RelationshipXref468
controller: AQP9 tetramer (name copied from entity in Homo sapiens)

Catalysis249
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction258
control type: ACTIVATION
xref: RelationshipXref487
xref: RelationshipXref413
controller: Homologues of SLC9C1

Catalysis248
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction257
control type: ACTIVATION
xref: RelationshipXref486
xref: RelationshipXref485
controller: Note: the coordinates are copied over from Homo sapiens.

Depyrimidination
type: Pathway
data source: Reactome
pathway component: REACT 88843.9
pathway component: Cleavage of the damaged pyrimidine
evidence: Evidence469
xref: RelationshipXref511
xref: UnificationXref3135
xref: UnificationXref3134
pathway order: PathwayStep452
pathway order: PathwayStep447
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref861
type: UnificationXref
id: REACT_24442
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24442.2

UnificationXref862
type: UnificationXref
id: CHEBI:32796
db: ChEBI

UnificationXref860
type: UnificationXref
id: 880046
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880046

UnificationXref875
type: UnificationXref
id: REACT_126183
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126183.5

UnificationXref874
type: UnificationXref
id: 4231407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231407

Catalysis250
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction259
control type: ACTIVATION
xref: RelationshipXref488
xref: RelationshipXref489
controller: GFPT1/2

UnificationXref877
type: UnificationXref
id: REACT_30207
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30207.10

UnificationXref876
type: UnificationXref
id: 4231260
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231260

Catalysis252
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction261
control type: ACTIVATION
xref: RelationshipXref500
xref: RelationshipXref499
controller: TAP (name copied from entity in Homo sapiens)

UnificationXref879
type: UnificationXref
id: REACT_114930
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114930.8

http://identifiers.org/pubmed/8382952
type: PublicationXref
id: 8382952
author: Pugh, EN
author: Lamb, TD
db: Pubmed
title: Amplification and kinetics of the activation steps in phototransduction
source: Biochim. Biophys. Acta 1141:111-49
year: 1993

Catalysis251
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction260
control type: ACTIVATION
xref: RelationshipXref491
xref: RelationshipXref490
controller: 2xUAP1-2 (name copied from entity in Homo sapiens)

UnificationXref878
type: UnificationXref
id: 4231261
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231261

Catalysis254
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction267
control type: ACTIVATION
xref: RelationshipXref510
xref: RelationshipXref508
controller: 3-alkyladenine DNA glycosylase

Catalysis253
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction266
control type: ACTIVATION
xref: RelationshipXref509
xref: RelationshipXref508
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis256
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction269
control type: ACTIVATION
xref: RelationshipXref510
xref: RelationshipXref508
controller: 3-alkyladenine DNA glycosylase

Catalysis255
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction268
control type: ACTIVATION
xref: RelationshipXref510
xref: RelationshipXref508
controller: 3-alkyladenine DNA glycosylase

Catalysis258
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction275
control type: ACTIVATION
xref: RelationshipXref512
xref: RelationshipXref513
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis257
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction274
control type: ACTIVATION
xref: RelationshipXref512
xref: RelationshipXref513
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis259
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction276
control type: ACTIVATION
xref: RelationshipXref512
xref: RelationshipXref513
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/18772396
type: PublicationXref
id: 18772396
author: Zhang, X
author: Shinjo, SM
author: Rasheed, BA
author: Lin, JC
author: Carter, H
author: Jones, S
author: Keir, S
author: Parmigiani, G
author: Yan, H
author: McLendon, R
author: Olivi, A
author: Nikolsky, Y
author: Diaz Jr, LA
author: Tekleab, H
author: Vogelstein, B
author: Kinzler, KW
author: Velculescu, VE
author: Papadopoulos, N
author: Mankoo, P
author: Marie, SK
author: Parsons, DW
author: Busam, DA
author: Riggins, GJ
author: Bigner, DD
author: Karchin, R
author: Hartigan, J
author: Angenendt, P
author: Leary, RJ
author: Smith, DR
author: Strausberg, RL
author: Gallia, GL
author: Siu, IM
author: Nikolskaya, T
db: Pubmed
title: An integrated genomic analysis of human glioblastoma multiforme
source: Science 321:1807-12
year: 2008

UnificationXref870
type: UnificationXref
id: 4231023
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231023

UnificationXref871
type: UnificationXref
id: REACT_128627
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128627.5

UnificationXref872
type: UnificationXref
id: 4231024
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231024

UnificationXref873
type: UnificationXref
id: REACT_143585
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_143585.5

Catalysis221
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction230
control type: ACTIVATION
xref: RelationshipXref445
xref: RelationshipXref444
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/15845384
type: PublicationXref
id: 15845384
author: Ohira, RH
author: Dipple, KM
author: McCabe, ER
author: Zhang, YH
db: Pubmed
title: Human and murine glycerol kinase: influence of exon 18 alternative splicing on function
source: Biochem Biophys Res Commun 331:239-46
year: 2005

Catalysis220
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction229
control type: ACTIVATION
xref: RelationshipXref443
xref: RelationshipXref442
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref889
type: UnificationXref
id: 4230200
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230200

UnificationXref888
type: UnificationXref
id: 4230198
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230198

UnificationXref887
type: UnificationXref
id: 4230197
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230197

UnificationXref886
type: UnificationXref
id: P99164
db: UniProt

UnificationXref885
type: UnificationXref
id: REACT_5071
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5071.2

Catalysis229
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction238
control type: ACTIVATION
xref: RelationshipXref455
xref: RelationshipXref458
controller: Homologues of SLC30A8

Catalysis228
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction237
control type: ACTIVATION
xref: RelationshipXref455
xref: RelationshipXref457
controller: Homologues of SLC30A3

Catalysis227
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction236
control type: ACTIVATION
xref: RelationshipXref456
xref: RelationshipXref455
controller: Homologues of SLC30A2

Catalysis226
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction235
control type: ACTIVATION
xref: RelationshipXref454
xref: RelationshipXref453
controller: SLC11A2

Catalysis225
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction234
control type: ACTIVATION
xref: RelationshipXref452
xref: RelationshipXref451
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis224
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction233
control type: ACTIVATION
xref: RelationshipXref450
xref: RelationshipXref449
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis223
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction232
control type: ACTIVATION
xref: RelationshipXref447
xref: RelationshipXref448
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis222
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction231
control type: ACTIVATION
xref: RelationshipXref446
xref: RelationshipXref444
controller: Solute carrier family 13 member 4

http://identifiers.org/pubmed/18388293
type: PublicationXref
id: 18388293
author: Kumar, R
author: An, S
author: Benkovic, SJ
author: Sheets, ED
db: Pubmed
title: Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
source: Science 320:103-6
year: 2008

UnificationXref883
type: UnificationXref
id: CHEBI:17909
db: ChEBI

UnificationXref884
type: UnificationXref
id: 111284
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111284

http://identifiers.org/pubmed/19178136
type: PublicationXref
id: 19178136
author: Ryoo, J
author: Lee, YJ
author: Kim, I
author: Kim, Y
author: Kang, K
author: Ahn, K
author: Jeong, E
author: Oh, C
db: Pubmed
title: Molecular mechanisms of MHC class I-antigen processing: redox considerations
source: Antioxid Redox Signal 11:907-36
year: 2009

UnificationXref881
type: UnificationXref
id: 71067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71067

UnificationXref882
type: UnificationXref
id: REACT_3428
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3428.2

UnificationXref880
type: UnificationXref
id: CHEBI:18248
db: ChEBI

http://identifiers.org/pubmed/2040271
type: PublicationXref
id: 2040271
author: Sadahiro, S
author: Matsuda, T
author: Takenaka, M
author: Tanaka, T
author: Noguchi, T
author: Hirai, H
author: Imai, E
author: Yamada, K
db: Pubmed
title: Isolation and characterization of the human pyruvate kinase M gene
source: Eur J Biochem 198:101-6
year: 1991

Catalysis230
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction239
control type: ACTIVATION
xref: RelationshipXref377
xref: RelationshipXref378
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis232
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction241
control type: ACTIVATION
xref: RelationshipXref213
xref: RelationshipXref212
controller: Protein104

Catalysis231
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction240
control type: ACTIVATION
xref: RelationshipXref459
xref: RelationshipXref460
controller: Urea transporters

UnificationXref897
type: UnificationXref
id: 4230205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230205

UnificationXref896
type: UnificationXref
id: 4230204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230204

UnificationXref899
type: UnificationXref
id: 113578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113578

UnificationXref898
type: UnificationXref
id: CHEBI:17345
db: ChEBI

Catalysis238
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction247
control type: ACTIVATION
xref: RelationshipXref469
xref: RelationshipXref468
controller: Aquaporins that transport water across the plasma membrane.

http://identifiers.org/pubmed/16839620
type: PublicationXref
id: 16839620
author: Kushner, JP
author: Phillips, JD
author: Ajioka, RS
db: Pubmed
title: Biosynthesis of heme in mammals
source: Biochim Biophys Acta 1763:723-36
year: 2006

Catalysis237
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction246
control type: ACTIVATION
xref: RelationshipXref467
xref: RelationshipXref466
controller: Aquaporins that transport water across the plasma membrane.

Catalysis239
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction248
control type: ACTIVATION
xref: RelationshipXref469
xref: RelationshipXref468
controller: Aquaporins that transport water across the plasma membrane.

Catalysis234
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction243
control type: ACTIVATION
xref: RelationshipXref463
xref: RelationshipXref461
controller: Homologues of SLC28A3

Catalysis233
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction242
control type: ACTIVATION
xref: RelationshipXref461
xref: RelationshipXref462
controller: Homologues of SLC28A1

Catalysis236
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction245
control type: ACTIVATION
xref: RelationshipXref467
xref: RelationshipXref466
controller: Aquaporins that transport water across the plasma membrane.

Catalysis235
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction244
control type: ACTIVATION
xref: RelationshipXref464
xref: RelationshipXref461
controller: Homologues of SLC28A2

UnificationXref892
type: UnificationXref
id: 4230206
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230206

UnificationXref893
type: UnificationXref
id: CHEBI:17202
db: ChEBI

UnificationXref894
type: UnificationXref
id: 29602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29602

UnificationXref895
type: UnificationXref
id: REACT_2342
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2342.1

UnificationXref890
type: UnificationXref
id: 4230203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230203

UnificationXref891
type: UnificationXref
id: REACT_99377
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99377.9

http://identifiers.org/pubmed/20919643
type: PublicationXref
id: 20919643
author: Gault, CR
author: Hannun, YA
author: Obeid, LM
db: Pubmed
title: An overview of sphingolipid metabolism: from synthesis to breakdown
source: Adv Exp Med Biol 688:1-23
year: 2010

http://identifiers.org/pubmed/18583706
type: PublicationXref
id: 18583706
author: Bakovic, M
author: Zhu, L
author: Johnson, C
db: Pubmed
title: Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1
source: J Lipid Res 49:2197-211
year: 2008

http://identifiers.org/pubmed/18597486
type: PublicationXref
id: 18597486
author: Frank, CG
author: Sanyal, S
author: Menon, AK
db: Pubmed
title: Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum
source: Biochemistry 47:7937-46
year: 2008

Catalysis260
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction277
control type: ACTIVATION
xref: RelationshipXref512
xref: RelationshipXref513
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis261
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction278
control type: ACTIVATION
xref: RelationshipXref516
xref: RelationshipXref517
controller: 6-O- methylguanine-DNA methyltransferase

http://identifiers.org/pubmed/11470804
type: PublicationXref
id: 11470804
author: Yamamoto, TT
author: Kamataki, A
author: Magoori, K
author: Takei, YA
author: Sakai, J
author: Sone, H
author: Fujino, T
author: Ioka, RX
author: Takahashi, S
db: Pubmed
title: Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product
source: J Biol Chem 276:35961-6
year: 2001

Abacavir transport and metabolism
type: Pathway
data source: Reactome
pathway component: Abacavir metabolism
evidence: Evidence297
xref: UnificationXref2230
xref: UnificationXref2231
pathway order: PathwayStep292
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19762341
type: PublicationXref
id: 19762341
author: Morikawa, M
author: Kamiya, Y
author: Miyazono, K
db: Pubmed
title: Bone morphogenetic protein receptors and signal transduction
source: J Biochem 147:35-51
year: 2010

The retinoid cycle in cones (daylight vision)
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction185
evidence: Evidence303
xref: RelationshipXref366
xref: UnificationXref2250
xref: UnificationXref2249
pathway order: PathwayStep297
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14999402
type: PublicationXref
id: 14999402
author: Kersten, S
author: Mandard, S
author: Muller, M
db: Pubmed
title: Peroxisome proliferator-activated receptor alpha target genes
source: Cell Mol Life Sci 61:393-416
year: 2004

UnificationXref1920
type: UnificationXref
id: 389556
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389556

UnificationXref1922
type: UnificationXref
id: Q7A6K3
db: UniProt

Glyoxylate
type: SmallMoleculeReference
name: Glyoxalate
name: Glyoxylic acid
name: Glyoxylate [ChEBI:5509]
xref: UnificationXref1903

UnificationXref1921
type: UnificationXref
id: REACT_17375
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17375.1

UnificationXref1924
type: UnificationXref
id: 4230772
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230772

UnificationXref1923
type: UnificationXref
id: 4230770
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230770

UnificationXref1925
type: UnificationXref
id: REACT_93956
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93956.9

UnificationXref1926
type: UnificationXref
id: 4231364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231364

UnificationXref1927
type: UnificationXref
id: REACT_89087
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89087.9

UnificationXref1928
type: UnificationXref
id: P66767
db: UniProt

UnificationXref1929
type: UnificationXref
id: 4230432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230432

UnificationXref1913
type: UnificationXref
id: 4230767
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230767

UnificationXref1912
type: UnificationXref
id: 4230765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230765

UnificationXref1911
type: UnificationXref
id: 4230764
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230764

UnificationXref1910
type: UnificationXref
id: Q7A543
db: UniProt

UnificationXref1916
type: UnificationXref
id: REACT_10257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10257.1

UnificationXref1917
type: UnificationXref
id: CHEBI:17497
db: ChEBI

UnificationXref1914
type: UnificationXref
id: REACT_87423
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87423.9

UnificationXref1915
type: UnificationXref
id: 193465
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193465

http://identifiers.org/pubmed/12811560
type: PublicationXref
id: 12811560
author: Edwards, RH
author: Reimer, RJ
db: Pubmed
title: Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
source: Pflugers Arch 447:629-35
year: 2004

UnificationXref1918
type: UnificationXref
id: 389822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389822

UnificationXref1919
type: UnificationXref
id: REACT_17366
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17366.1

http://identifiers.org/pubmed/12811562
type: PublicationXref
id: 12811562
author: Bartoloni, L
author: Antonarakis, SE
db: Pubmed
title: The human sugar-phosphate/phosphate exchanger family SLC37
source: Pflugers Arch 447:780-3
year: 2004

UnificationXref1944
type: UnificationXref
id: REACT_117448
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117448.1

UnificationXref1943
type: UnificationXref
id: 1614585
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614585

UnificationXref1946
type: UnificationXref
id: 4231135
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231135

UnificationXref1945
type: UnificationXref
id: Q7A7L0
db: UniProt

UnificationXref1940
type: UnificationXref
id: 174369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174369

UnificationXref1942
type: UnificationXref
id: CHEBI:17724
db: ChEBI

UnificationXref1941
type: UnificationXref
id: REACT_7731
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7731.2

UnificationXref802
type: UnificationXref
id: REACT_4970
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4970.1

UnificationXref801
type: UnificationXref
id: 113526
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113526

http://identifiers.org/pubmed/18511455
type: PublicationXref
id: 18511455
author: Giacomini, KM
author: Hurowitz, E
author: Zador, Z
author: Sorani, MD
author: Manley, GT
author: Yan, D
db: Pubmed
title: Novel variants in human Aquaporin-4 reduce cellular water permeability
source: Hum Mol Genet 17:2379-89
year: 2008

UnificationXref804
type: UnificationXref
id: REACT_5633
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5633.1

UnificationXref803
type: UnificationXref
id: 113600
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113600

UnificationXref1947
type: UnificationXref
id: 4231136
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231136

UnificationXref1948
type: UnificationXref
id: 4231138
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231138

UnificationXref800
type: UnificationXref
id: REACT_100736
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100736.9

UnificationXref1949
type: UnificationXref
id: REACT_131192
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131192.5

http://identifiers.org/pubmed/15381398
type: PublicationXref
id: 15381398
author: Jaffe, EK
db: Pubmed
title: The porphobilinogen synthase catalyzed reaction mechanism
source: Bioorg Chem 32:316-25
year: 2004

UnificationXref809
type: UnificationXref
id: P99151
db: UniProt

UnificationXref806
type: UnificationXref
id: REACT_2390
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2390.1

UnificationXref805
type: UnificationXref
id: 29362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29362

UnificationXref808
type: UnificationXref
id: REACT_5783
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5783.1

UnificationXref807
type: UnificationXref
id: 113563
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113563

UnificationXref1935
type: UnificationXref
id: REACT_159813
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159813.3

UnificationXref1934
type: UnificationXref
id: 4230438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230438

UnificationXref1933
type: UnificationXref
id: 4230436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230436

UnificationXref1932
type: UnificationXref
id: 4230435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230435

http://identifiers.org/pubmed/12140278
type: PublicationXref
id: 12140278
author: Yanagihara, K
author: Egashira, Y
author: Sanada, H
author: Ishiguro, K
author: Shibata, K
author: Fukuoka, S
author: Tanabe, A
db: Pubmed
title: Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".
source: J Biol Chem 277:35162-7
year: 2002

UnificationXref1931
type: UnificationXref
id: 4230434
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230434

UnificationXref1930
type: UnificationXref
id: 4230433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230433

UnificationXref815
type: UnificationXref
id: 4230975
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230975

UnificationXref814
type: UnificationXref
id: 4230973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230973

http://identifiers.org/pubmed/7535000
type: PublicationXref
id: 7535000
author: Carone, FA
author: Perrone, RD
author: Brown, D
author: Jefferson, DM
author: Bachinsky, DR
author: Emmanouel, DS
author: Sabolic, I
db: Pubmed
title: Water channel expression in human ADPKD kidneys
source: Am J Physiol 268:F398
year: 1995

UnificationXref813
type: UnificationXref
id: 4230972
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230972

UnificationXref812
type: UnificationXref
id: 4230971
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230971

UnificationXref811
type: UnificationXref
id: Q99TF4
db: UniProt

UnificationXref1938
type: UnificationXref
id: REACT_13965
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13965.2

UnificationXref810
type: UnificationXref
id: 4230968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230968

UnificationXref1939
type: UnificationXref
id: CHEBI:17230
db: ChEBI

UnificationXref1936
type: UnificationXref
id: CHEBI:17750
db: ChEBI

UnificationXref1937
type: UnificationXref
id: 352015
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352015

UnificationXref819
type: UnificationXref
id: REACT_3871
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3871.2

UnificationXref818
type: UnificationXref
id: 113594
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113594

UnificationXref817
type: UnificationXref
id: CHEBI:30915
db: ChEBI

UnificationXref816
type: UnificationXref
id: REACT_132904
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132904.5

Catalysis209
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction218
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref424
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis208
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction217
control type: ACTIVATION
xref: RelationshipXref423
xref: RelationshipXref374
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis200
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction209
control type: ACTIVATION
xref: RelationshipXref418
xref: RelationshipXref419
controller: Electrogenic Na+/Pi cotransporters

UnificationXref827
type: UnificationXref
id: Q7A5N4
db: UniProt

Catalysis201
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction210
control type: ACTIVATION
xref: RelationshipXref418
xref: RelationshipXref420
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref828
type: UnificationXref
id: MOD:00127
db: MOD

Catalysis202
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction211
control type: ACTIVATION
xref: RelationshipXref421
xref: RelationshipXref418
controller: Type III Na+/Pi cotransporters

UnificationXref829
type: UnificationXref
id: 4229973
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229973

Catalysis203
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction212
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref422
controller: SLC1A4

Catalysis204
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction213
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref422
controller: SLC1A4

Catalysis205
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction214
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref422
controller: SLC1A4

Catalysis206
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction215
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref422
controller: SLC1A4

Catalysis207
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction216
control type: ACTIVATION
xref: RelationshipXref423
xref: RelationshipXref374
controller: Note: the coordinates are copied over from Homo sapiens.

http://identifiers.org/pubmed/12646417
type: PublicationXref
id: 12646417
author: Said, HM
author: Ortiz, Alvaro
author: Balamurugan, K
db: Pubmed
title: Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system
source: Am. J. Physiol. Gastrointest. Liver Physiol. 285:G73-7
year: 2003

UnificationXref820
type: UnificationXref
id: CHEBI:15380
db: ChEBI

UnificationXref821
type: UnificationXref
id: 70958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70958

UnificationXref822
type: UnificationXref
id: REACT_2852
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2852.2

UnificationXref823
type: UnificationXref
id: P99084
db: UniProt

UnificationXref824
type: UnificationXref
id: 4229915
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229915

http://identifiers.org/pubmed/7923172
type: PublicationXref
id: 7923172
author: Momparler, RL
author: Laliberte, J
db: Pubmed
title: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA
source: Cancer Res 54:5401-7
year: 1994

UnificationXref825
type: UnificationXref
id: 4229916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229916

UnificationXref826
type: UnificationXref
id: 4229917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229917

http://identifiers.org/pubmed/20435355
type: PublicationXref
id: 20435355
author: Palczewski, Krzysztof
db: Pubmed
title: Retinoids for treatment of retinal diseases
source: Trends Pharmacol. Sci. 31:284-95
year: 2010

Catalysis219
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction228
control type: ACTIVATION
xref: RelationshipXref439
xref: RelationshipXref440
controller: Sodium-coupled monocarboxylate transporter 1

Catalysis213
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction222
control type: ACTIVATION
xref: RelationshipXref429
xref: RelationshipXref428
controller: Excitatory amino acid transporters

Catalysis214
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction223
control type: ACTIVATION
xref: RelationshipXref430
xref: RelationshipXref431
controller: VGLUTs

Catalysis211
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction220
control type: ACTIVATION
xref: RelationshipXref425
xref: RelationshipXref374
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref838
type: UnificationXref
id: REACT_2518
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2518.3

Catalysis212
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction221
control type: ACTIVATION
xref: RelationshipXref426
xref: RelationshipXref374
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref839
type: UnificationXref
id: 4229968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229968

Catalysis217
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction226
control type: ACTIVATION
xref: RelationshipXref436
xref: RelationshipXref435
controller: Protein159

Catalysis218
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction227
control type: ACTIVATION
xref: RelationshipXref438
xref: RelationshipXref437
controller: Sodium-coupled monocarboxylate transporter 1

Catalysis215
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction224
control type: ACTIVATION
xref: RelationshipXref433
xref: RelationshipXref432
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis216
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction225
control type: ACTIVATION
xref: RelationshipXref418
xref: RelationshipXref434
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref832
type: UnificationXref
id: REACT_3209
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3209.3

UnificationXref833
type: UnificationXref
id: 4229974
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229974

UnificationXref830
type: UnificationXref
id: CHEBI:17460
db: ChEBI

UnificationXref831
type: UnificationXref
id: 29824
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29824

UnificationXref836
type: UnificationXref
id: CHEBI:18290
db: ChEBI

Catalysis210
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction219
control type: ACTIVATION
xref: RelationshipXref425
xref: RelationshipXref374
controller: Note: the coordinates are copied over from Homo sapiens.

UnificationXref837
type: UnificationXref
id: 113547
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113547

UnificationXref834
type: UnificationXref
id: Q99U74
db: UniProt

UnificationXref835
type: UnificationXref
id: 4229967
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229967

UnificationXref1900
type: UnificationXref
id: CHEBI:16977
db: ChEBI

UnificationXref840
type: UnificationXref
id: 4229969
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229969

UnificationXref1901
type: UnificationXref
id: 389664
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389664

UnificationXref1902
type: UnificationXref
id: REACT_18000
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18000.2

http://identifiers.org/pubmed/12899834
type: PublicationXref
id: 12899834
author: Roe, SM
author: Zhang, X
author: Rao, Z
author: Bartlam, M
author: Hou, Y
author: Danpure, CJ
author: Pearl, LH
db: Pubmed
title: Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
source: J Mol Biol 331:643-52
year: 2003

http://identifiers.org/pubmed/19381358
type: PublicationXref
id: 19381358
author: Torti, FM
author: Shulaev, V
author: Mendes, P
author: Laubenbacher, R
author: Akman, S
author: Torti, SV
author: Hower, V
db: Pubmed
title: A general map of iron metabolism and tissue-specific subnetworks
source: Mol Biosyst 5:422-43
year: 2009

UnificationXref849
type: UnificationXref
id: REACT_4778
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4778.2

UnificationXref845
type: UnificationXref
id: 113588
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113588

UnificationXref1908
type: UnificationXref
id: 193446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193446

UnificationXref846
type: UnificationXref
id: REACT_5289
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5289.2

UnificationXref1907
type: UnificationXref
id: REACT_17481
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17481.2

UnificationXref847
type: UnificationXref
id: CHEBI:30797
db: ChEBI

UnificationXref848
type: UnificationXref
id: 113544
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113544

UnificationXref1909
type: UnificationXref
id: REACT_10649
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10649.2

UnificationXref841
type: UnificationXref
id: 4229975
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229975

UnificationXref1904
type: UnificationXref
id: 389678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389678

UnificationXref842
type: UnificationXref
id: 4230020
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230020

UnificationXref1903
type: UnificationXref
id: CHEBI:16891
db: ChEBI

UnificationXref843
type: UnificationXref
id: REACT_100909
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100909.9

UnificationXref1906
type: UnificationXref
id: 389680
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=389680

UnificationXref844
type: UnificationXref
id: CHEBI:18012
db: ChEBI

UnificationXref1905
type: UnificationXref
id: REACT_17634
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17634.1

UnificationXref851
type: UnificationXref
id: 4229961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229961

UnificationXref850
type: UnificationXref
id: P64173
db: UniProt

http://identifiers.org/pubmed/9435697
type: PublicationXref
id: 9435697
author: Giacomini, KM
author: Wang, J
author: Schaner, ME
author: Su, SF
author: Washington, CB
author: Dresser, MJ
db: Pubmed
title: Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization
source: Am J Physiol Renal Physiol 273:1058-1065
year: 1997

http://identifiers.org/pubmed/6395883
type: PublicationXref
id: 6395883
author: Bosron, WF
author: Li, TK
author: Magnes, LJ
author: Yin, SJ
db: Pubmed
title: Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 "Oriental" isoenzymes.
source: Biochemistry 23:5847-53
year: 1985

http://identifiers.org/pubmed/20807551
type: PublicationXref
id: 20807551
author: Noël, Jacques
author: Diochot, Sylvie
author: Baron, Anne
author: Deval, Emmanuel
author: Gasull, Xavier
author: Salinas, Miguel
author: Lingueglia, Eric
db: Pubmed
title: Acid-sensing ion channels (ASICs): pharmacology and implication in pain
source: Pharmacol. Ther. 128:549-58
year: 2010

UnificationXref858
type: UnificationXref
id: REACT_84181
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84181.9

UnificationXref859
type: UnificationXref
id: CHEBI:16265
db: ChEBI

http://identifiers.org/pubmed/19261456
type: PublicationXref
id: 19261456
author: Procko, E
author: Gaudet, R
db: Pubmed
title: Antigen processing and presentation: TAPping into ABC transporters
source: Curr Opin Immunol 21:84-91
year: 2009

UnificationXref856
type: UnificationXref
id: REACT_141512
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141512.5

UnificationXref857
type: UnificationXref
id: 4231270
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231270

UnificationXref854
type: UnificationXref
id: REACT_96178
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96178.9

UnificationXref855
type: UnificationXref
id: 4230976
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230976

UnificationXref852
type: UnificationXref
id: 4229962
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229962

UnificationXref853
type: UnificationXref
id: 4229964
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229964

http://identifiers.org/pubmed/518841
type: PublicationXref
id: 518841
author: O'Brien, WE
db: Pubmed
title: Isolation and characterization of argininosuccinate synthetase from human liver.
source: Biochemistry 18:5353-6
year: 1980

UnificationXref1870
type: UnificationXref
id: Q7A862
db: UniProt

UnificationXref1872
type: UnificationXref
id: 4230646
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230646

UnificationXref1871
type: UnificationXref
id: 4230644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230644

UnificationXref1878
type: UnificationXref
id: 4230649
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230649

UnificationXref1877
type: UnificationXref
id: P99158
db: UniProt

UnificationXref1879
type: UnificationXref
id: 4230651
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230651

UnificationXref1874
type: UnificationXref
id: CHEBI:17148
db: ChEBI

UnificationXref1873
type: UnificationXref
id: REACT_112250
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112250.8

UnificationXref1876
type: UnificationXref
id: REACT_2757
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2757.1

UnificationXref1875
type: UnificationXref
id: 29610
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29610

6-Phospho-D-glucono-1,5-lactone
type: SmallMoleculeReference
name: D-Glucono-1,5-lactone 6-phosphate [ChEBI:16938]
name: D-Glucono-1,5-lactone 6-phosphate
xref: UnificationXref236

UnificationXref1883
type: UnificationXref
id: 4229895
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229895

UnificationXref1882
type: UnificationXref
id: REACT_33455
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33455.10

UnificationXref1881
type: UnificationXref
id: 4231352
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231352

UnificationXref1880
type: UnificationXref
id: REACT_154706
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154706.3

http://identifiers.org/pubmed/18632300
type: PublicationXref
id: 18632300
author: den Hollander, Anneke I
author: Cremers, Frans P M
author: Roepman, Ronald
author: Koenekoop, Robert K
db: Pubmed
title: Leber congenital amaurosis: genes, proteins and disease mechanisms
source: Prog Retin Eye Res 27:391-419
year: 2008

2Iron-2Sulfur Cluster
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2046
cellular location: intracellular
display name: 2Fe-2S Cluster
comment: Reactome DB_ID: 4230480

GPX1/2/4
type: PhysicalEntity
data source: Reactome
xref: UnificationXref626
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231179
member physical entity: GPX2 tetramer (name copied from entity in Homo sapiens)
member physical entity: GPX1 tetramer (name copied from entity in Homo sapiens)
member physical entity: Homologues of GPX4(?-197)

GPX1/2/4
type: PhysicalEntity
data source: Reactome
xref: UnificationXref611
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231184
member physical entity: GPX1 tetramer (name copied from entity in Homo sapiens)
member physical entity: Homologues of GPX4(?-197)

UnificationXref1889
type: UnificationXref
id: 209818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209818

ACHE oligomer
type: PhysicalEntity
data source: Reactome
xref: UnificationXref513
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230665
member physical entity: ACHE dimer (name copied from entity in Homo sapiens)
member physical entity: ACHE tetramer (name copied from entity in Homo sapiens)
member physical entity: Q7A3P6

UnificationXref1888
type: UnificationXref
id: CHEBI:16382
db: ChEBI

UnificationXref1887
type: UnificationXref
id: REACT_108771
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_108771.9

UnificationXref1886
type: UnificationXref
id: 4231266
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231266

http://identifiers.org/pubmed/4358634
type: PublicationXref
id: 4358634
author: Roth, DG
author: Deuel, TF
author: Shelton, E
db: Pubmed
title: Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
source: J Biol Chem 249:291-296
year: 1974

UnificationXref1885
type: UnificationXref
id: REACT_112162
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112162.8

UnificationXref1884
type: UnificationXref
id: 4229897
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229897

http://identifiers.org/pubmed/21479626
type: PublicationXref
id: 21479626
author: Sass, JO
db: Pubmed
title: Inborn errors of ketogenesis and ketone body utilization
source: J Inherit Metab Dis
year: 2011

L-Kynurenine [ChEBI:16946]
type: SmallMoleculeReference
name: 3-Anthraniloyl-L-alanine
name: L-Kynurenine
xref: UnificationXref1765

UnificationXref1890
type: UnificationXref
id: REACT_15764
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15764.2

UnificationXref1892
type: UnificationXref
id: REACT_15695
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15695.2

UnificationXref1891
type: UnificationXref
id: 209785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=209785

UnificationXref1894
type: UnificationXref
id: 4230624
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230624

UnificationXref1893
type: UnificationXref
id: 4230622
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230622

UnificationXref1896
type: UnificationXref
id: 4231340
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231340

UnificationXref1895
type: UnificationXref
id: REACT_104008
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104008.9

UnificationXref1898
type: UnificationXref
id: 4231341
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231341

UnificationXref1897
type: UnificationXref
id: REACT_80508
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80508.9

UnificationXref1899
type: UnificationXref
id: REACT_105403
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105403.9

http://identifiers.org/pubmed/10551886
type: PublicationXref
id: 10551886
author: Duncan, JA
author: Yamashita, S
author: Michel, T
author: Yeh, DC
db: Pubmed
title: Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin
source: J Biol Chem 274:33148-54
year: 1999

http://identifiers.org/pubmed/16865347
type: PublicationXref
id: 16865347
author: Gundelfinger, ED
author: Schoch, S
db: Pubmed
title: Molecular organization of the presynaptic active zone
source: Cell Tissue Res 326:379-91
year: 2006

http://identifiers.org/pubmed/8283301
type: PublicationXref
id: 8283301
author: Rudolph, FB
db: Pubmed
title: The biochemistry and physiology of nucleotides
source: J Nutr 124:124S-127S
year: 1994

http://identifiers.org/pubmed/14988808
type: PublicationXref
id: 14988808
author: Jakobs, C
author: Huck, JH
author: Verhoeven, NM
author: van der Knaap, MS
author: Struys, EA
author: Salomons, GS
db: Pubmed
title: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy
source: Am J Hum Genet 74:745-51
year: 2004

UnificationXref1838
type: UnificationXref
id: 31369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31369

UnificationXref1837
type: UnificationXref
id: CHEBI:16244
db: ChEBI

UnificationXref1839
type: UnificationXref
id: REACT_4905
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4905.2

UnificationXref1833
type: UnificationXref
id: REACT_77801
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77801.9

UnificationXref1834
type: UnificationXref
id: CHEBI:18020
db: ChEBI

UnificationXref1835
type: UnificationXref
id: 31311
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31311

UnificationXref1836
type: UnificationXref
id: REACT_4362
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4362.2

17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
type: SmallMoleculeReference
name: Cortisone
name: Kendall's compound E
name: Cortisone [ChEBI:3896]
name: Reichstein's substance Fa
xref: UnificationXref469

http://identifiers.org/pubmed/14559994
type: PublicationXref
id: 14559994
author: Iwakoshi, NN
author: Lee, AH
author: Glimcher, LH
db: Pubmed
title: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
source: Mol Cell Biol 23:7448-59
year: 2003

UnificationXref1830
type: UnificationXref
id: 4230980
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230980

abacavir [ChEBI:421707]
type: SmallMoleculeReference
name: abacavir
name: {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
xref: UnificationXref2212

UnificationXref1831
type: UnificationXref
id: REACT_136759
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136759.5

UnificationXref1832
type: UnificationXref
id: 4231262
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231262

http://identifiers.org/pubmed/22796206
type: PublicationXref
id: 22796206
author: Hausmann, George
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: WNT secretion and signalling in human disease
source: Trends Mol Med 18:483-93
year: 2012

http://identifiers.org/pubmed/13538944
type: PublicationXref
id: 13538944
author: Tsuboi, KK
author: Hudson, PB
author: Estrada, J
db: Pubmed
title: Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.
source: J Biol Chem 231:19-29
year: 1958

L-Alanine [ChEBI:16977]
type: SmallMoleculeReference
name: L-alpha-Alanine
name: L-Alanine
name: L-2-Aminopropionic acid
xref: UnificationXref1900

UnificationXref1849
type: UnificationXref
id: REACT_5739
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5739.2

UnificationXref1848
type: UnificationXref
id: 29916
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29916

UnificationXref1846
type: UnificationXref
id: REACT_153869
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153869.3

UnificationXref1847
type: UnificationXref
id: CHEBI:16919
db: ChEBI

UnificationXref1844
type: UnificationXref
id: REACT_153750
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153750.3

UnificationXref1845
type: UnificationXref
id: 4231273
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231273

UnificationXref1842
type: UnificationXref
id: 4230000
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230000

UnificationXref1843
type: UnificationXref
id: 4230002
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230002

UnificationXref1840
type: UnificationXref
id: Q7A399
db: UniProt

UnificationXref1841
type: UnificationXref
id: 4229999
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229999

http://identifiers.org/pubmed/1755855
type: PublicationXref
id: 1755855
author: Chen, CS
author: Yoshida, A
db: Pubmed
title: Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene
source: Biochem Biophys Res Commun 181:743-7
year: 1991

http://identifiers.org/pubmed/14530973
type: PublicationXref
id: 14530973
author: Mackenzie, B
author: Hediger, MA
db: Pubmed
title: SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1
source: Pflugers Arch 447:571-9
year: 2004

UnificationXref1859
type: UnificationXref
id: 4230579
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230579

http://identifiers.org/pubmed/11591158
type: PublicationXref
id: 11591158
author: Wolf, S
author: Gnauert, K
author: Vékony, N
author: Boissel, JP
author: Closs, EI
db: Pubmed
title: Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues
source: Biochemistry 40:12387-94
year: 2001

UnificationXref1851
type: UnificationXref
id: 200351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200351

UnificationXref1852
type: UnificationXref
id: REACT_11683
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_11683.2

UnificationXref1853
type: UnificationXref
id: P65206
db: UniProt

UnificationXref1854
type: UnificationXref
id: 4230574
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230574

UnificationXref1855
type: UnificationXref
id: 4230575
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230575

UnificationXref1856
type: UnificationXref
id: 4230577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230577

UnificationXref1857
type: UnificationXref
id: REACT_111938
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111938.8

UnificationXref1858
type: UnificationXref
id: 4230578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230578

UnificationXref1850
type: UnificationXref
id: CHEBI:17287
db: ChEBI

UnificationXref1864
type: UnificationXref
id: REACT_112531
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112531.8

http://identifiers.org/pubmed/18243674
type: PublicationXref
id: 18243674
author: Purcell, AW
author: Elliott, T
db: Pubmed
title: Molecular machinations of the MHC-I peptide loading complex
source: Curr Opin Immunol 20:75-81
year: 2008

UnificationXref1865
type: UnificationXref
id: 4231336
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231336

UnificationXref1862
type: UnificationXref
id: 4230582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230582

UnificationXref1863
type: UnificationXref
id: 4230584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230584

UnificationXref1868
type: UnificationXref
id: 351164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=351164

UnificationXref1869
type: UnificationXref
id: REACT_15151
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15151.2

UnificationXref1866
type: UnificationXref
id: REACT_112303
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112303.8

UnificationXref1867
type: UnificationXref
id: CHEBI:17431
db: ChEBI

UnificationXref1860
type: UnificationXref
id: 4230580
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230580

UnificationXref1861
type: UnificationXref
id: 4230581
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230581

UnificationXref2922
type: UnificationXref
id: Q7A3E6
db: UniProt

UnificationXref2923
type: UnificationXref
id: 4231033
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231033

UnificationXref2924
type: UnificationXref
id: 4231035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231035

UnificationXref2925
type: UnificationXref
id: REACT_135348
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135348.5

D-Glucosamine 6-phosphate [ChEBI:4164]
type: SmallMoleculeReference
name: D-Glucosamine phosphate
name: D-Glucosamine 6-phosphate
xref: UnificationXref2965

UnificationXref2920
type: UnificationXref
id: 437295
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437295

UnificationXref2921
type: UnificationXref
id: REACT_21200
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21200.2

UnificationXref2927
type: UnificationXref
id: REACT_26878
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_26878.2

UnificationXref2926
type: UnificationXref
id: 936901
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=936901

UnificationXref2929
type: UnificationXref
id: 4231038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231038

UnificationXref2928
type: UnificationXref
id: 4231036
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231036

UnificationXref2935
type: UnificationXref
id: REACT_3382
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3382.2

UnificationXref2936
type: UnificationXref
id: 2892454
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2892454

UnificationXref2933
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

UnificationXref2934
type: UnificationXref
id: 113551
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113551

UnificationXref2931
type: UnificationXref
id: 4231408
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231408

UnificationXref2932
type: UnificationXref
id: REACT_126481
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126481.5

UnificationXref2930
type: UnificationXref
id: REACT_136488
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136488.5

UnificationXref2939
type: UnificationXref
id: 4231240
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231240

UnificationXref2938
type: UnificationXref
id: 4231238
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231238

UnificationXref2937
type: UnificationXref
id: REACT_161161
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161161.1

http://identifiers.org/pubmed/15948717
type: PublicationXref
id: 15948717
author: Calamita, G
author: Agre, P
author: Nagase, H
author: Liu, K
author: Huang, CG
db: Pubmed
title: Purification and functional characterization of aquaporin-8
source: Biol Cell 98:153-61
year: 2006

http://identifiers.org/pubmed/9307043
type: PublicationXref
id: 9307043
author: Gilliam, T
author: Sugiyama, T
author: Yang, XL
author: Kawarada, Y
author: Miura, N
author: Terada, K
author: Petrukhin, K
db: Pubmed
title: Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments
source: Biochem J 326:897-902
year: 1997

Catalysis3
type: Catalysis
data source: Reactome
controlled: Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
control type: ACTIVATION
xref: RelationshipXref7
xref: RelationshipXref8
controller: Complex2

Catalysis2
type: Catalysis
data source: Reactome
controlled: Glucose 6-phosphate is isomerized to form fructose-6-phosphate
control type: ACTIVATION
xref: RelationshipXref6
xref: RelationshipXref5
controller: Complex1

Catalysis5
type: Catalysis
data source: Reactome
controlled: dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
control type: ACTIVATION
xref: RelationshipXref12
xref: RelationshipXref11
controller: triosephosphate isomerase dimer (name copied from entity in Homo sapiens)

Catalysis4
type: Catalysis
data source: Reactome
controlled: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
control type: ACTIVATION
xref: RelationshipXref9
xref: RelationshipXref10
controller: Complex7

Catalysis7
type: Catalysis
data source: Reactome
controlled: 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
control type: ACTIVATION
xref: RelationshipXref16
xref: RelationshipXref15
controller: enolase 1 dimer, (alpha) (name copied from entity in Homo sapiens)

Catalysis6
type: Catalysis
data source: Reactome
controlled: 1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
control type: ACTIVATION
xref: RelationshipXref13
xref: RelationshipXref14
controller: phosphoglycerate kinase 1 complex (name copied from entity in Homo sapiens)

Catalysis9
type: Catalysis
data source: Reactome
controlled: Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
control type: ACTIVATION
xref: RelationshipXref20
xref: RelationshipXref21
controller: pyruvate carboxylase holoenzyme (name copied from entity in Homo sapiens)

Catalysis8
type: Catalysis
data source: Reactome
controlled: phosphoenolpyruvate + ADP => pyruvate + ATP
control type: ACTIVATION
xref: RelationshipXref17
xref: RelationshipXref18
controller: pyruvate kinase tetramer

UnificationXref2940
type: UnificationXref
id: REACT_161689
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161689.2

UnificationXref2941
type: UnificationXref
id: CHEBI:17775
db: ChEBI

UnificationXref2942
type: UnificationXref
id: 30034
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30034

UnificationXref2943
type: UnificationXref
id: REACT_3681
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3681.1

UnificationXref2944
type: UnificationXref
id: 429056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=429056

UnificationXref2945
type: UnificationXref
id: REACT_19945
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_19945.1

UnificationXref2946
type: UnificationXref
id: 4231235
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231235

Catalysis1
type: Catalysis
data source: Reactome
controlled: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
control type: ACTIVATION
xref: RelationshipXref1
xref: RelationshipXref2
controller: Nitric oxide synthase

UnificationXref2947
type: UnificationXref
id: 4231237
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231237

UnificationXref2949
type: UnificationXref
id: GO:0036126
db: GENE ONTOLOGY

UnificationXref2948
type: UnificationXref
id: REACT_162892
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162892.2

(R)-5-Diphosphomevalonate [ChEBI:332]
type: SmallMoleculeReference
name: (R)-5-Diphosphomevalonate
xref: UnificationXref453

Phospholipid metabolism
type: Pathway
data source: Reactome
pathway component: Glycerophospholipid biosynthesis
evidence: Evidence70
xref: RelationshipXref80
xref: UnificationXref534
xref: UnificationXref533
pathway order: PathwayStep66
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2950
type: UnificationXref
id: 2872447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2872447

http://identifiers.org/pubmed/14725767
type: PublicationXref
id: 14725767
author: Bate, M
author: Luke, RW
author: McAlister, MS
author: Ernill, RJ
author: Norman, RA
author: Paterson, DS
author: Barry, ST
author: Colls, JG
author: Tucker, JA
author: Breed, J
author: McCall, EJ
author: Minshull, CA
author: Timms, D
author: Pauptit, RA
author: McMiken, HH
db: Pubmed
title: Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
source: Structure 12:75-84
year: 2004

UnificationXref2953
type: UnificationXref
id: REACT_161011
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161011.1

UnificationXref2954
type: UnificationXref
id: 4231230
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231230

UnificationXref2951
type: UnificationXref
id: REACT_161253
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161253.1

UnificationXref2952
type: UnificationXref
id: 2872443
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2872443

UnificationXref2957
type: UnificationXref
id: 4231234
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231234

UnificationXref2958
type: UnificationXref
id: REACT_162845
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162845.2

UnificationXref2955
type: UnificationXref
id: 4231231
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231231

UnificationXref2956
type: UnificationXref
id: 4231232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231232

UnificationXref2959
type: UnificationXref
id: 4231443
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231443

http://identifiers.org/pubmed/19278523
type: PublicationXref
id: 19278523
author: Dulhunty, Angela F
author: Wei, Lan
author: Beard, Nicole A
db: Pubmed
title: Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen
source: Clin. Exp. Pharmacol. Physiol. 36:340-5
year: 2009

Coenzyme QH2
type: SmallMoleculeReference
name: QH2
name: CoQH2
name: ubiquinol
name: ubiquinol [ChEBI:17976]
xref: UnificationXref1143

UnificationXref2967
type: UnificationXref
id: REACT_22935
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22935.2

UnificationXref2966
type: UnificationXref
id: 449701
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=449701

UnificationXref2969
type: UnificationXref
id: 4230956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230956

UnificationXref2968
type: UnificationXref
id: P64228
db: UniProt

UnificationXref2963
type: UnificationXref
id: 4231298
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231298

UnificationXref2962
type: UnificationXref
id: REACT_132869
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_132869.5

UnificationXref2965
type: UnificationXref
id: CHEBI:15873
db: ChEBI

UnificationXref2964
type: UnificationXref
id: REACT_102348
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102348.9

UnificationXref2961
type: UnificationXref
id: 4231409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231409

UnificationXref2960
type: UnificationXref
id: REACT_162081
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162081.2

http://identifiers.org/pubmed/224930
type: PublicationXref
id: 224930
author: Inoue, K
author: Yamasawa, K
author: Nishimukai, H
db: Pubmed
title: Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.
source: Biochim Biophys Acta 569:117-23
year: 1979

http://identifiers.org/pubmed/18436705
type: PublicationXref
id: 18436705
author: Scheuner, D
author: Kaufman, RJ
db: Pubmed
title: The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
source: Endocr Rev 29:317-33
year: 2008

UnificationXref2979
type: UnificationXref
id: REACT_3203
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3203.2

UnificationXref2978
type: UnificationXref
id: 162756
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162756

UnificationXref2977
type: UnificationXref
id: CHEBI:16264
db: ChEBI

http://identifiers.org/pubmed/22108505
type: PublicationXref
id: 22108505
author: Basler, Konrad
author: Herr, Patrick
db: Pubmed
title: Porcupine-mediated lipidation is required for Wnt recognition by Wls
source: Dev. Biol. 361:392-402
year: 2012

Orotidine 5'-phosphate [ChEBI:15842]
type: SmallMoleculeReference
name: Orotidylic acid
name: Orotidine 5'-phosphate
xref: UnificationXref1156

UnificationXref2976
type: UnificationXref
id: REACT_23093
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23093.2

UnificationXref2975
type: UnificationXref
id: 532204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=532204

UnificationXref2974
type: UnificationXref
id: CHEBI:7125
db: ChEBI

http://identifiers.org/pubmed/3372530
type: PublicationXref
id: 3372530
author: Sherley, JL
author: Kelly, TJ
db: Pubmed
title: Regulation of human thymidine kinase during the cell cycle
source: J Biol Chem 263:8350-8358
year: 1988

UnificationXref2973
type: UnificationXref
id: REACT_133392
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133392.5

UnificationXref2972
type: UnificationXref
id: 4230960
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230960

UnificationXref2971
type: UnificationXref
id: 4230958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230958

UnificationXref2970
type: UnificationXref
id: 4230957
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230957

Transport of vitamins, nucleosides, and related molecules
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction241
pathway component: REACT 103903.9
evidence: Evidence394
xref: UnificationXref2875
xref: UnificationXref2874
pathway order: PathwayStep380
pathway order: PathwayStep384
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

NAD
type: SmallMoleculeReference
name: NAD+ [ChEBI:15846]
name: DPN
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref226

UnificationXref2985
type: UnificationXref
id: REACT_147073
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147073.5

UnificationXref2984
type: UnificationXref
id: 4230953
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230953

UnificationXref2987
type: UnificationXref
id: REACT_131987
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131987.5

UnificationXref2986
type: UnificationXref
id: 4231390
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231390

UnificationXref2989
type: UnificationXref
id: REACT_139862
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139862.5

UnificationXref2988
type: UnificationXref
id: 4231391
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231391

Chloride [ChEBI:17996]
type: SmallMoleculeReference
name: Chloride
xref: UnificationXref2803

UnificationXref2981
type: UnificationXref
id: 4230949
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230949

UnificationXref2980
type: UnificationXref
id: Q7A4A4
db: UniProt

UnificationXref2983
type: UnificationXref
id: 4230951
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230951

UnificationXref2982
type: UnificationXref
id: 4230950
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230950

NADH
type: SmallMoleculeReference
name: NADH [ChEBI:16908]
xref: UnificationXref766

oligopeptide fragment
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3009
cellular location: intracellular
comment: Reactome DB_ID: 4231085

N-Carbamoyl-L-aspartate
type: SmallMoleculeReference
name: N-Carbamoyl-L-aspartate [ChEBI:15859]
xref: UnificationXref1129

D-Fructose 1,6-bisphosphate
type: SmallMoleculeReference
name: D-Fructose 1,6-bisphosphate [ChEBI:16905]
xref: UnificationXref80

oligopeptide fragment (8-16aa)
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3008
cellular location: intracellular
comment: Reactome DB_ID: 4231084

Na+/H+ exchanger proteins 7/8
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2550
cellular location: intracellular
display name: SLC9A7/8
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230821
member physical entity: Homologues of SLC9A8(1-577)
member physical entity: Homologues of SLC9A7

Na+/H+ exchanger proteins
type: PhysicalEntity
data source: Reactome
xref: UnificationXref2526
cellular location: plasma membrane
display name: SLC9A1-5
comment: Reactome DB_ID: 4230812
comment: Converted from EntitySet in Reactome
member physical entity: Homologues of SLC9A3
member physical entity: Homologues of SLC9A5
member physical entity: Homologues of SLC9A2
member physical entity: Homologues of SLC9A4
member physical entity: Homologues of SLC9A1

Double-strand DNA containing a 3-methyladenine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3047
cellular location: intracellular
comment: Reactome DB_ID: 4230346

UnificationXref2998
type: UnificationXref
id: 4231422
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231422

UnificationXref2997
type: UnificationXref
id: REACT_142540
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142540.5

UnificationXref2996
type: UnificationXref
id: 4231145
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231145

http://identifiers.org/pubmed/22983114
type: PublicationXref
id: 22983114
author: Boutros, Michael
author: Bartscherer, Kerstin
author: Chaudhary, Varun
author: Gross, Julia Christina
db: Pubmed
title: Active Wnt proteins are secreted on exosomes
source: Nat. Cell Biol. 14:1036-45
year: 2012

UnificationXref2995
type: UnificationXref
id: REACT_147604
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_147604.5

UnificationXref2999
type: UnificationXref
id: REACT_145679
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145679.5

UnificationXref2990
type: UnificationXref
id: 4231392
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231392

UnificationXref2994
type: UnificationXref
id: 4231394
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231394

UnificationXref2993
type: UnificationXref
id: REACT_139262
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_139262.5

UnificationXref2992
type: UnificationXref
id: 4231393
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231393

UnificationXref2991
type: UnificationXref
id: REACT_131164
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131164.5

Methylglycocyamine
type: SmallMoleculeReference
name: Creatine
name: alpha-Methylguanidino acetic acid
name: Creatine [ChEBI:16919]
xref: UnificationXref1847

o-Hydroxybenzoic acid
type: SmallMoleculeReference
name: salicylic acid
name: salicylic acid [ChEBI:16914]
name: Salicylate
xref: UnificationXref2194

Catalysis108
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction113
control type: ACTIVATION
xref: RelationshipXref222
xref: RelationshipXref221
controller: Protein109

Catalysis107
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction112
control type: ACTIVATION
xref: RelationshipXref220
xref: RelationshipXref219
controller: Protein109

Catalysis106
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction111
control type: ACTIVATION
xref: RelationshipXref218
xref: RelationshipXref217
controller: 3xPPCDC:3xFMN (name copied from entity in Homo sapiens)

Catalysis105
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction110
control type: ACTIVATION
xref: RelationshipXref214
xref: RelationshipXref216
controller: Protein106

Catalysis104
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction109
control type: ACTIVATION
xref: RelationshipXref215
xref: RelationshipXref214
controller: Protein105

Catalysis103
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction108
control type: ACTIVATION
xref: RelationshipXref213
xref: RelationshipXref212
controller: Protein104

Catalysis102
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction107
control type: ACTIVATION
xref: RelationshipXref209
xref: RelationshipXref210
controller: ITPA dimer (name copied from entity in Homo sapiens)

Catalysis101
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction106
control type: ACTIVATION
xref: RelationshipXref208
xref: RelationshipXref207
controller: ITPA dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/20153287
type: PublicationXref
id: 20153287
author: Wallace, J C
author: Bailey, L M
author: Polyak, S W
db: Pubmed
title: Holocarboxylase synthetase: correlation of protein localisation with biological function
source: Arch. Biochem. Biophys. 496:45-52
year: 2010

Catalysis100
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction105
control type: ACTIVATION
xref: RelationshipXref205
xref: RelationshipXref206
controller: ITPA dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/8298639
type: PublicationXref
id: 8298639
author: Forbes, JR
author: Bull, PC
author: Cox, DW
author: Rommens, JM
author: Thomas, GR
db: Pubmed
title: The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
source: Nat Genet 5:327-37
year: 1993

Catalysis109
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction114
control type: ACTIVATION
xref: RelationshipXref213
xref: RelationshipXref212
controller: Protein104

http://identifiers.org/pubmed/6249820
type: PublicationXref
id: 6249820
author: Pierson, DL
author: Brien, JM
db: Pubmed
title: Human carbamylphosphate synthetase I. Stabilization, purification, and partial characterization of the enzyme from human liver.
source: J Biol Chem 255:7891-5
year: 1980

Catalysis117
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction123
control type: ACTIVATION
xref: RelationshipXref237
xref: RelationshipXref236
controller: 2xMTHFD1 (name copied from entity in Homo sapiens)

Catalysis116
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction122
control type: ACTIVATION
xref: RelationshipXref234
xref: RelationshipXref235
controller: 2xMTHFD1 (name copied from entity in Homo sapiens)

Catalysis119
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction125
control type: ACTIVATION
xref: RelationshipXref238
xref: RelationshipXref239
controller: 2xMTHFD1 (name copied from entity in Homo sapiens)

Catalysis118
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction124
control type: ACTIVATION
xref: RelationshipXref238
xref: RelationshipXref239
controller: 2xMTHFD1 (name copied from entity in Homo sapiens)

Catalysis113
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction119
control type: ACTIVATION
xref: RelationshipXref232
xref: RelationshipXref233
controller: Protein113

Catalysis112
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction118
control type: ACTIVATION
xref: RelationshipXref230
xref: RelationshipXref231
controller: Protein112

Catalysis115
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction121
control type: ACTIVATION
xref: RelationshipXref232
xref: RelationshipXref233
controller: Protein113

Catalysis114
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction120
control type: ACTIVATION
xref: RelationshipXref232
xref: RelationshipXref233
controller: Protein113

Catalysis111
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction117
control type: ACTIVATION
xref: RelationshipXref230
xref: RelationshipXref231
controller: Protein112

Catalysis110
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction116
control type: ACTIVATION
xref: RelationshipXref227
xref: RelationshipXref226
controller: 2xNAPRT1 (name copied from entity in Homo sapiens)

Catalysis126
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction132
control type: ACTIVATION
xref: RelationshipXref252
xref: RelationshipXref253
controller: PHGHD tetramer (name copied from entity in Homo sapiens)

Catalysis125
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction131
control type: ACTIVATION
xref: RelationshipXref251
xref: RelationshipXref250
controller: OAT hexamer (name copied from entity in Homo sapiens)

Catalysis124
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction130
control type: ACTIVATION
xref: RelationshipXref251
xref: RelationshipXref250
controller: OAT hexamer (name copied from entity in Homo sapiens)

Catalysis123
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction129
control type: ACTIVATION
xref: RelationshipXref245
xref: RelationshipXref246
controller: 3xGPHN:3xMg2+ (name copied from entity in Homo sapiens)

Catalysis129
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction135
control type: ACTIVATION
xref: RelationshipXref261
xref: RelationshipXref262
controller: urocanate hydratase (name copied from entity in Homo sapiens)

formamidopyrimidine
type: SmallMoleculeReference
name: 5-formamidopyrimidine
name: ChEBI:35877 5-formamidopyrimidine
xref: UnificationXref3127

Catalysis128
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction134
control type: ACTIVATION
xref: RelationshipXref260
xref: RelationshipXref259
controller: Protein134

Catalysis127
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction133
control type: ACTIVATION
xref: RelationshipXref256
xref: RelationshipXref257
controller: branched-chain alpha-ketoacid dehydrogenase complex (name copied from entity in Homo sapiens)

UnificationXref987
type: UnificationXref
id: 4230159
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230159

UnificationXref986
type: UnificationXref
id: P99106
db: UniProt

UnificationXref985
type: UnificationXref
id: REACT_3823
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3823.2

UnificationXref984
type: UnificationXref
id: 111584
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111584

Catalysis122
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction128
control type: ACTIVATION
xref: RelationshipXref244
xref: RelationshipXref243
controller: 2xMOCS2-CO-S(1-):2xMOCS2B (name copied from entity in Homo sapiens)

Catalysis121
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction127
control type: ACTIVATION
xref: RelationshipXref242
xref: RelationshipXref241
controller: holo-MOCS1 (name copied from entity in Homo sapiens)

UnificationXref989
type: UnificationXref
id: 4230162
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230162

Catalysis120
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction126
control type: ACTIVATION
xref: RelationshipXref237
xref: RelationshipXref236
controller: 2xMTHFD1 (name copied from entity in Homo sapiens)

UnificationXref988
type: UnificationXref
id: 4230160
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230160

http://identifiers.org/pubmed/19783045
type: PublicationXref
id: 19783045
author: Kongsuphol, Patthara
author: Kunzelmann, Karl
author: Schreiber, Rainer
author: Warth, R
author: Tian, Yuemin
author: Ousingsawat, Jiraporn
author: Aldehni, Fadi
db: Pubmed
title: Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions
source: Cell Calcium 46:233-41
year: 2009

UnificationXref982
type: UnificationXref
id: REACT_94292
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94292.9

UnificationXref983
type: UnificationXref
id: CHEBI:15652
db: ChEBI

UnificationXref980
type: UnificationXref
id: REACT_33070
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33070.10

UnificationXref981
type: UnificationXref
id: 4230169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230169

http://identifiers.org/pubmed/3893466
type: PublicationXref
id: 3893466
author: Jornvall, H
db: Pubmed
title: Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
source: Alcohol 2:61-6
year: 1985

Catalysis135
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction141
control type: ACTIVATION
xref: RelationshipXref272
xref: RelationshipXref271
controller: TAT dimer (name copied from entity in Homo sapiens)

Catalysis134
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction140
control type: ACTIVATION
xref: RelationshipXref268
xref: RelationshipXref269
controller: GCDH tetramer (name copied from entity in Homo sapiens)

Catalysis137
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction143
control type: ACTIVATION
xref: RelationshipXref274
xref: RelationshipXref275
controller: ALDH4A1 dimer (name copied from entity in Homo sapiens)

Catalysis136
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction142
control type: ACTIVATION
xref: RelationshipXref272
xref: RelationshipXref271
controller: TAT dimer (name copied from entity in Homo sapiens)

Catalysis139
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction145
control type: ACTIVATION
xref: RelationshipXref280
xref: RelationshipXref279
controller: AADAT dimer (name copied from entity in Homo sapiens)

Catalysis138
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction144
control type: ACTIVATION
xref: RelationshipXref277
xref: RelationshipXref278
controller: ACMSD dimer (name copied from entity in Homo sapiens)

UnificationXref996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

UnificationXref995
type: UnificationXref
id: REACT_32520
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32520.10

UnificationXref998
type: UnificationXref
id: REACT_2875
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2875.1

UnificationXref997
type: UnificationXref
id: 29438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438

Catalysis131
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction137
control type: ACTIVATION
xref: RelationshipXref267
xref: RelationshipXref266
controller: AADAT dimer (name copied from entity in Homo sapiens)

UnificationXref999
type: UnificationXref
id: CHEBI:15919
db: ChEBI

Catalysis130
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction136
control type: ACTIVATION
xref: RelationshipXref263
xref: RelationshipXref264
controller: Protein136

Catalysis133
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction139
control type: ACTIVATION
xref: RelationshipXref124
xref: RelationshipXref123
controller: alpha-ketoglutarate dehydrogenase complex (name copied from entity in Homo sapiens)

Catalysis132
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction138
control type: ACTIVATION
xref: RelationshipXref267
xref: RelationshipXref266
controller: AADAT dimer (name copied from entity in Homo sapiens)

UnificationXref990
type: UnificationXref
id: REACT_33597
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33597.10

UnificationXref991
type: UnificationXref
id: 4230163
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230163

UnificationXref992
type: UnificationXref
id: P99105
db: UniProt

UnificationXref993
type: UnificationXref
id: 4230154
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230154

http://identifiers.org/pubmed/8662720
type: PublicationXref
id: 8662720
author: Korenberg, J
author: Garrow, TA
author: Qi, H
author: Choi, YJ
author: Shane, B
author: Chen, L
db: Pubmed
title: Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
source: J Biol Chem 271:13077-87
year: 1996

UnificationXref994
type: UnificationXref
id: 4230156
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230156

L-Lactic acid
type: SmallMoleculeReference
name: L-Lactate
name: (S)-Lactate
name: (S)-Lactate [ChEBI:422]
xref: UnificationXref769

Cell Cycle, Mitotic
type: Pathway
data source: Reactome
pathway component: REACT 140703.5
evidence: Evidence445
xref: RelationshipXref506
xref: UnificationXref3041
xref: UnificationXref3042
pathway order: PathwayStep430
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/14500886
type: PublicationXref
id: 14500886
author: Green, S
author: Warrington, JA
author: Davis, S
author: Wolfe, CL
author: Norcum, MT
db: Pubmed
title: Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII
source: Protein Sci 12:2282-90
year: 2003

Catalysis143
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction149
control type: ACTIVATION
xref: RelationshipXref288
xref: RelationshipXref289
controller: ASL tetramer (name copied from entity in Homo sapiens)

Catalysis144
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction150
control type: ACTIVATION
xref: RelationshipXref290
xref: RelationshipXref291
controller: ARG1 trimer (name copied from entity in Homo sapiens)

Catalysis141
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction147
control type: ACTIVATION
xref: RelationshipXref284
xref: RelationshipXref285
controller: OTC trimer (name copied from entity in Homo sapiens)

Catalysis142
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction148
control type: ACTIVATION
xref: RelationshipXref287
xref: RelationshipXref286
controller: ASS1 tetramer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/18457821
type: PublicationXref
id: 18457821
author: Groner, E
author: Weinstock, M
db: Pubmed
title: Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity
source: Chem Biol Interact
year: 2008

Catalysis140
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction146
control type: ACTIVATION
xref: RelationshipXref283
xref: RelationshipXref282
controller: Protein142

Catalysis149
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction155
control type: ACTIVATION
xref: RelationshipXref301
xref: RelationshipXref302
controller: Protein156

Catalysis147
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction153
control type: ACTIVATION
xref: RelationshipXref297
xref: RelationshipXref298
controller: creatine kinase BB dimer (name copied from entity in Homo sapiens)

Catalysis148
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction154
control type: ACTIVATION
xref: RelationshipXref297
xref: RelationshipXref299
controller: creatine kinase octamers

Catalysis145
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction151
control type: ACTIVATION
xref: RelationshipXref290
xref: RelationshipXref292
controller: ARG2 trimer (name copied from entity in Homo sapiens)

Catalysis146
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction152
control type: ACTIVATION
xref: RelationshipXref294
xref: RelationshipXref295
controller: ALDH9A1 tetramer (name copied from entity in Homo sapiens)

Synthesis and interconversion of nucleotide di- and triphosphates
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction103
pathway component: BiochemicalReaction101
pathway component: BiochemicalReaction102
pathway component: BiochemicalReaction104
pathway component: BiochemicalReaction100
pathway component: BiochemicalReaction99
evidence: Evidence170
xref: UnificationXref1387
xref: UnificationXref1386
xref: RelationshipXref204
pathway order: PathwayStep165
pathway order: PathwayStep162
pathway order: PathwayStep161
pathway order: PathwayStep164
pathway order: PathwayStep166
pathway order: PathwayStep163
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

(5Z,8Z,10E,14Z)-(12R)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoic acid
type: SmallMoleculeReference
name: (5Z,8Z,10E,14Z)-(12R)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid
name: 12(R)-HPETE [ChEBI:34145]
name: 12(R)-HPETE
xref: UnificationXref631

12(S)-hydroxyeicosatetraenoic acid
type: SmallMoleculeReference
name: 12S-HETE
name: 12(S)-HETE
name: 12(S)-hydroxy-5,8,14(Z),10(E)-eicosatetraenoic acid
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
name: 12(S)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
name: (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
name: (5Z,8Z,10E,12S,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid
name: 12(S)-HETE [ChEBI:34146]
name: (12S)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
xref: UnificationXref642

12(R)-hydroxyeicosatetraenoic acid
type: SmallMoleculeReference
name: (5Z,8Z,10E,12R,14Z)-12-hydroxy-5,8,10,14-eicosatetraenoic acid
name: 12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
name: 12(R)-HETE
name: 12(R)-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
name: (5Z,8Z,10E,14Z)-(12R)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
name: (5Z,8Z,10E,14Z)-(12R)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
name: (5Z,8Z,10E,12R,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid
name: 12R-HETE
name: 12(R)-HETE [ChEBI:34144]
xref: UnificationXref634

Catalysis152
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction158
control type: ACTIVATION
xref: RelationshipXref309
xref: RelationshipXref310
controller: Protein159

Catalysis153
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction159
control type: ACTIVATION
xref: RelationshipXref312
xref: RelationshipXref313
controller: AGXT dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/16435184
type: PublicationXref
id: 16435184
author: Ten Brink, HJ
author: Jakobs, C
author: Gibson, KM
author: Verhoeven, NM
author: Struys, EA
author: Wickenhagen, WV
db: Pubmed
title: Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
source: J Inherit Metab Dis 28:921-30
year: 2005

Catalysis154
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction160
control type: ACTIVATION
xref: RelationshipXref314
xref: RelationshipXref315
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis155
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction161
control type: ACTIVATION
xref: RelationshipXref318
xref: RelationshipXref317
controller: MAT multimers

http://identifiers.org/pubmed/11604561
type: PublicationXref
id: 11604561
author: Cattaneo, M
author: Ruggeri, ZM
author: Savage, B
db: Pubmed
title: Mechanisms of platelet aggregation
source: Curr Opin Hematol 8:270-6
year: 2001

Catalysis150
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction156
control type: ACTIVATION
xref: RelationshipXref303
xref: RelationshipXref304
controller: Protein157

Catalysis151
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction157
control type: ACTIVATION
xref: RelationshipXref307
xref: RelationshipXref306
controller: Protein158

Catalysis156
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction162
control type: ACTIVATION
xref: RelationshipXref320
xref: RelationshipXref319
controller: BHMT tetramer (name copied from entity in Homo sapiens)

Catalysis157
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction163
control type: ACTIVATION
xref: RelationshipXref322
xref: RelationshipXref321
controller: SQR:FAD (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/7512951
type: PublicationXref
id: 7512951
author: Sessa, WC
author: Liu, J
db: Pubmed
title: Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase
source: J Biol Chem 269:11691-4
year: 1994

Catalysis158
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction165
control type: ACTIVATION
xref: RelationshipXref327
xref: RelationshipXref328
controller: 8x(ALAD:Zn2+) (name copied from entity in Homo sapiens)

Catalysis159
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction166
control type: ACTIVATION
xref: RelationshipXref330
xref: RelationshipXref329
controller: HMBS:DIPY (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/16746585
type: PublicationXref
id: 16746585
author: Salvin, E
author: Johnson, WA
author: Krebs, HA
db: Pubmed
title: The formation of citric and alpha-ketoglutaric acids in the mammalian body
source: Biochem J 32:113-117
year: 1938

Deoxycytidine [ChEBI:15698]
type: SmallMoleculeReference
name: Deoxycytidine
name: 2'-Deoxycytidine
xref: UnificationXref1246

Catalysis161
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction168
control type: ACTIVATION
xref: RelationshipXref332
xref: RelationshipXref331
controller: 2xUROD (name copied from entity in Homo sapiens)

Catalysis162
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction169
control type: ACTIVATION
xref: RelationshipXref334
xref: RelationshipXref333
controller: 2xPPO:FAD (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/8618861
type: PublicationXref
id: 8618861
author: Nevins, JR
author: DeGregori, J
author: Ohtani, K
db: Pubmed
title: Regulation of the cyclin E gene by transcription factor E2F1
source: Proc Natl Acad Sci U S A 92:12146-50
year: 1995

Catalysis160
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction167
control type: ACTIVATION
xref: RelationshipXref332
xref: RelationshipXref331
controller: 2xUROD (name copied from entity in Homo sapiens)

Catalysis165
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction172
control type: ACTIVATION
xref: RelationshipXref342
xref: RelationshipXref341
controller: alcohol dehydrogenase complex

Catalysis166
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction173
control type: ACTIVATION
xref: RelationshipXref343
xref: RelationshipXref344
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis163
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction170
control type: ACTIVATION
xref: RelationshipXref335
xref: RelationshipXref336
controller: 2x(FECH:2Fe-2S cluster) (name copied from entity in Homo sapiens)

Catalysis164
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction171
control type: ACTIVATION
xref: RelationshipXref338
xref: RelationshipXref337
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis169
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction177
control type: ACTIVATION
xref: RelationshipXref352
xref: RelationshipXref353
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis167
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction174
control type: ACTIVATION
xref: RelationshipXref345
xref: RelationshipXref343
controller: Note: the coordinates are copied over from Homo sapiens.

Sulfur
type: SmallMoleculeReference
name: Sulfur, precipitated
name: S
name: Sulfur [ChEBI:17909]
xref: UnificationXref883

Catalysis168
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction175
control type: ACTIVATION
xref: RelationshipXref349
xref: RelationshipXref348
controller: 6xUGDH (name copied from entity in Homo sapiens)

L-Argininosuccinate
type: SmallMoleculeReference
name: N(omega)-(L-Arginino)succinate
name: N-(L-Arginino)succinate [ChEBI:15682]
name: L-Argininosuccinic acid
name: N-(L-Arginino)succinate
name: L-Arginosuccinic acid
xref: UnificationXref1801

Catalysis170
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction178
control type: ACTIVATION
xref: RelationshipXref352
xref: RelationshipXref353
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis171
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction179
control type: ACTIVATION
xref: RelationshipXref356
xref: RelationshipXref355
controller: xenobiotic/medium-chain fatty acid:CoA ligases

Catalysis172
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction180
control type: ACTIVATION
xref: RelationshipXref356
xref: RelationshipXref355
controller: xenobiotic/medium-chain fatty acid:CoA ligases

Catalysis173
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction181
control type: ACTIVATION
xref: RelationshipXref357
xref: RelationshipXref355
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis174
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction182
control type: ACTIVATION
xref: RelationshipXref359
xref: RelationshipXref358
controller: ADH1A dimer (name copied from entity in Homo sapiens)

Catalysis175
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction183
control type: ACTIVATION
xref: RelationshipXref360
xref: RelationshipXref361
controller: Protein100

Catalysis176
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction185
control type: ACTIVATION
xref: RelationshipXref364
xref: RelationshipXref365
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis177
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction186
control type: ACTIVATION
xref: RelationshipXref368
xref: RelationshipXref369
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis178
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction187
control type: ACTIVATION
xref: RelationshipXref372
xref: RelationshipXref373
controller: lactate dehydrogenase B4 complex (name copied from entity in Homo sapiens)

Catalysis179
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction188
control type: ACTIVATION
xref: RelationshipXref374
xref: RelationshipXref375
controller: Neuronal EAATs

Bile salt and organic anion SLC transporters
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction229
pathway component: REACT 95170.9
evidence: Evidence475
xref: UnificationXref3153
xref: UnificationXref3152
pathway order: PathwayStep369
pathway order: PathwayStep363
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref5
type: RelationshipXref
id: GO:0004347
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref4
type: RelationshipXref
id: GO:0031018
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref3
type: RelationshipXref
id: GO:0007596
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref2
type: RelationshipXref
id: 4230781
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230781

RelationshipXref1
type: RelationshipXref
id: GO:0004517
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref9
type: RelationshipXref
id: GO:0003872
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref8
type: RelationshipXref
id: 4230074
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230074

Catalysis180
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction189
control type: ACTIVATION
xref: RelationshipXref377
xref: RelationshipXref378
controller: Note: the coordinates are copied over from Homo sapiens.

RelationshipXref7
type: RelationshipXref
id: GO:0003873
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref6
type: RelationshipXref
id: 4229793
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229793

UnificationXref927
type: UnificationXref
id: CHEBI:15637
db: ChEBI

UnificationXref926
type: UnificationXref
id: REACT_88947
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88947.9

UnificationXref929
type: UnificationXref
id: REACT_18590
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18590.3

http://identifiers.org/pubmed/11051212
type: PublicationXref
id: 11051212
author: Szkopinska, A
db: Pubmed
title: Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization
source: Acta Biochim Pol 47:469-80
year: 2000

UnificationXref928
type: UnificationXref
id: 419151
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=419151

UnificationXref923
type: UnificationXref
id: P99163
db: UniProt

UnificationXref922
type: UnificationXref
id: REACT_5626
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5626.2

UnificationXref925
type: UnificationXref
id: 4230194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230194

UnificationXref924
type: UnificationXref
id: 4230188
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230188

UnificationXref921
type: UnificationXref
id: 111338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111338

UnificationXref920
type: UnificationXref
id: CHEBI:18349
db: ChEBI

http://identifiers.org/pubmed/18043707
type: PublicationXref
id: 18043707
author: Hamm, HE
author: Oldham, WM
db: Pubmed
title: Heterotrimeric G protein activation by G-protein-coupled receptors
source: Nat Rev Mol Cell Biol 9:60-71
year: 2008

UnificationXref939
type: UnificationXref
id: 111369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111369

UnificationXref938
type: UnificationXref
id: CHEBI:18413
db: ChEBI

http://identifiers.org/pubmed/3790084
type: PublicationXref
id: 3790084
author: Casazza, JP
author: Veech, RL
db: Pubmed
title: The content of pentose-cycle intermediates in liver in starved, fed ad libitum and meal-fed rats.
source: Biochem J 236:635-41
year: 1987

UnificationXref937
type: UnificationXref
id: REACT_100477
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100477.9

http://identifiers.org/pubmed/19204114
type: PublicationXref
id: 19204114
author: Schlessinger, Karni
author: Tolwinski, Nicholas
author: Hall, Alan
db: Pubmed
title: Wnt signaling pathways meet Rho GTPases
source: Genes Dev. 23:265-77
year: 2009

UnificationXref936
type: UnificationXref
id: 4230192
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230192

UnificationXref935
type: UnificationXref
id: REACT_3964
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3964.3

UnificationXref934
type: UnificationXref
id: 111355
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111355

UnificationXref933
type: UnificationXref
id: CHEBI:15635
db: ChEBI

UnificationXref932
type: UnificationXref
id: REACT_3395
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3395.2

UnificationXref931
type: UnificationXref
id: 111354
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111354

UnificationXref930
type: UnificationXref
id: CHEBI:18272
db: ChEBI

UnificationXref905
type: UnificationXref
id: 29472
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29472

UnificationXref904
type: UnificationXref
id: CHEBI:18050
db: ChEBI

UnificationXref907
type: UnificationXref
id: CHEBI:17284
db: ChEBI

UnificationXref906
type: UnificationXref
id: REACT_2473
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2473.2

UnificationXref909
type: UnificationXref
id: REACT_4144
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4144.2

UnificationXref908
type: UnificationXref
id: 111292
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111292

UnificationXref901
type: UnificationXref
id: 4230201
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230201

UnificationXref900
type: UnificationXref
id: REACT_2761
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2761.1

UnificationXref903
type: UnificationXref
id: 4230202
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230202

UnificationXref902
type: UnificationXref
id: REACT_103295
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103295.9

http://identifiers.org/pubmed/19574955
type: PublicationXref
id: 19574955
author: Beitz, E
author: Wu, B
author: Alsterfjord, M
author: Zeuthen, T
author: Steinbronn, C
db: Pubmed
title: Concerted action of two cation filters in the aquaporin water channel
source: EMBO J 28:2188-94
year: 2009

ADP [ChEBI:16761]
type: SmallMoleculeReference
name: ADP
name: Adenosine 5'-diphosphate
xref: UnificationXref61

http://identifiers.org/pubmed/5940
type: PublicationXref
id: 5940
author: Povey, S
author: Wilson, Jr, DE
author: Harris, H
db: Pubmed
title: Adenylate kinases in man: evidence for a third locus
source: Ann Hum Genet 39:305-313
year: 1976

http://identifiers.org/pubmed/10095107
type: PublicationXref
id: 10095107
author: Bartrons, R
author: Nadal, M
author: Manzano, A
author: Perez, JX
author: Lange, A
author: Estivill, X
db: Pubmed
title: Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
source: Gene 229:83-9
year: 1999

1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
type: SmallMoleculeReference
name: 5'-Phosphoribosyl-5-amino-4-imidazolecarboxylate [ChEBI:28413]
name: 5'-Phosphoribosyl-4-carboxy-5-aminoimidazole
name: 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
name: CAIR
name: 1-(5'-Phosphoribosyl)-4-carboxy-5-aminoimidazole
name: 5'-Phosphoribosyl-5-amino-4-imidazolecarboxylate
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
xref: UnificationXref946

UnificationXref918
type: UnificationXref
id: 29424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29424

UnificationXref917
type: UnificationXref
id: CHEBI:15428
db: ChEBI

http://identifiers.org/pubmed/7005231
type: PublicationXref
id: 7005231
author: Wermuth, B
db: Pubmed
title: Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase
source: J Biol Chem 256:1206-13
year: 1981

UnificationXref916
type: UnificationXref
id: 4230208
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230208

UnificationXref915
type: UnificationXref
id: 4230209
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230209

UnificationXref919
type: UnificationXref
id: REACT_5814
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5814.4

UnificationXref910
type: UnificationXref
id: CHEBI:16015
db: ChEBI

UnificationXref914
type: UnificationXref
id: REACT_30841
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30841.10

UnificationXref913
type: UnificationXref
id: 4230207
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230207

UnificationXref912
type: UnificationXref
id: REACT_4309
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4309.3

UnificationXref911
type: UnificationXref
id: 29404
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29404

http://identifiers.org/pubmed/14592814
type: PublicationXref
id: 14592814
author: Marples, D
author: Mobasheri, A
db: Pubmed
title: Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology
source: Am J Physiol Cell Physiol 286:C529-37
year: 2004

UnificationXref961
type: UnificationXref
id: REACT_110520
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110520.9

UnificationXref960
type: UnificationXref
id: 4230183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230183

http://identifiers.org/pubmed/12084581
type: PublicationXref
id: 12084581
author: Imai, M
author: Morinaga, T
author: Ishibashi, K
author: Sasaki, S
author: Kuwahara, M
db: Pubmed
title: Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin
source: Biochim Biophys Acta 1576:335-40
year: 2002

UnificationXref966
type: UnificationXref
id: 111409
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111409

UnificationXref967
type: UnificationXref
id: REACT_2302
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2302.2

UnificationXref968
type: UnificationXref
id: Q7A4Q3
db: UniProt

UnificationXref969
type: UnificationXref
id: 4230174
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230174

UnificationXref962
type: UnificationXref
id: CHEBI:37154
db: ChEBI

UnificationXref963
type: UnificationXref
id: 29586
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29586

UnificationXref964
type: UnificationXref
id: REACT_5412
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5412.3

UnificationXref965
type: UnificationXref
id: CHEBI:18406
db: ChEBI

http://identifiers.org/pubmed/10524214
type: PublicationXref
id: 10524214
author: Cregeen, DP
author: Rumsby, G
db: Pubmed
title: Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase
source: Biochim Biophys Acta 1446:383-8
year: 1999

UnificationXref972
type: UnificationXref
id: REACT_104702
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104702.9

UnificationXref971
type: UnificationXref
id: 4230177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230177

UnificationXref970
type: UnificationXref
id: 4230175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230175

4-Imidazolone-5-propanoate [ChEBI:27384]
type: SmallMoleculeReference
name: 4-Imidazolone-5-propionic acid
name: 4-Imidazolone-5-propanoate
name: 4,5-Dihydro-4-oxo-5-imidazolepropanoate
xref: UnificationXref1685

UnificationXref979
type: UnificationXref
id: 4230171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230171

http://identifiers.org/pubmed/5666113
type: PublicationXref
id: 5666113
author: Luzzatto, L
author: Afolayan, A
db: Pubmed
title: Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants
source: J Clin Invest 47:1833-42
year: 1968

UnificationXref977
type: UnificationXref
id: 4230166
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230166

UnificationXref978
type: UnificationXref
id: 4230167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230167

UnificationXref975
type: UnificationXref
id: REACT_4103
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4103.2

UnificationXref976
type: UnificationXref
id: P67544
db: UniProt

UnificationXref973
type: UnificationXref
id: CHEBI:18381
db: ChEBI

http://identifiers.org/pubmed/18165232
type: PublicationXref
id: 18165232
author: Kobayashi, T
author: Matsui, H
author: Tamura, S
author: Tomishige, N
author: Saito, S
author: Kumagai, K
author: Kawano, M
author: Echigo, S
author: Hanada, K
db: Pubmed
title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes
source: J Biol Chem 283:6584-93
year: 2008

UnificationXref974
type: UnificationXref
id: 111427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111427

http://identifiers.org/pubmed/8380692
type: PublicationXref
id: 8380692
author: Itakura, M
author: Kudo, E
author: Yoshimoto, K
author: Mizusawa, N
author: Holmes, EW
author: Ii, S
author: Oka, J
author: Iwahana, H
db: Pubmed
title: Molecular cloning of human amidophosphoribosyltransferase
source: Biochem Biophys Res Commun 190:192-200
year: 1993

15-Keto-PGF2a
type: SmallMoleculeReference
name: 15-Keto-prostaglandin F2alpha
name: 15-Keto-prostaglandin F2alpha [ChEBI:760]
name: 15-Keto-prostaglandin F2a
name: 15-Keto-PGF2alpha
xref: UnificationXref560

Stoichiometry3
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

Stoichiometry2
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

Stoichiometry5
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

Stoichiometry4
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

Stoichiometry7
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 4.0

Stoichiometry6
type: Stoichiometry
physical entity: PFK-B
stoichiometric coefficient: 4.0

Stoichiometry9
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 3.0

Stoichiometry8
type: Stoichiometry
physical entity: PFK-B
stoichiometric coefficient: 1.0

UnificationXref940
type: UnificationXref
id: REACT_2513
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2513.2

UnificationXref941
type: UnificationXref
id: CHEBI:28843
db: ChEBI

UnificationXref942
type: UnificationXref
id: 111370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111370

UnificationXref943
type: UnificationXref
id: REACT_4927
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4927.2

UnificationXref944
type: UnificationXref
id: 4230190
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230190

UnificationXref945
type: UnificationXref
id: REACT_94295
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94295.9

UnificationXref946
type: UnificationXref
id: CHEBI:28413
db: ChEBI

UnificationXref947
type: UnificationXref
id: 111395
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111395

Stoichiometry1
type: Stoichiometry
physical entity: Note: the coordinates are copied over from Homo sapiens.
stoichiometric coefficient: 2.0

UnificationXref948
type: UnificationXref
id: REACT_3113
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3113.2

UnificationXref949
type: UnificationXref
id: P99064
db: UniProt

http://identifiers.org/pubmed/16825786
type: PublicationXref
id: 16825786
author: Debut, AJ
author: Saier MH, Jr
author: Mansour, NM
author: Dumay, QC
db: Pubmed
title: The copper transporter (Ctr) family of Cu+ uptake systems
source: J Mol Microbiol Biotechnol 11:10-9
year: 2006

UnificationXref950
type: UnificationXref
id: 4230180
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230180

UnificationXref953
type: UnificationXref
id: REACT_78332
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78332.9

UnificationXref954
type: UnificationXref
id: CHEBI:17053
db: ChEBI

UnificationXref951
type: UnificationXref
id: 4230181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230181

UnificationXref952
type: UnificationXref
id: 4230185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230185

UnificationXref957
type: UnificationXref
id: CHEBI:18319
db: ChEBI

UnificationXref958
type: UnificationXref
id: 111399
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111399

UnificationXref955
type: UnificationXref
id: 29448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29448

UnificationXref956
type: UnificationXref
id: REACT_4653
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4653.3

UnificationXref959
type: UnificationXref
id: REACT_3661
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3661.2

http://identifiers.org/pubmed/21554866
type: PublicationXref
id: 21554866
author: Cox, Brian J
author: Biechele, Steffen
author: Rossant, Janet
db: Pubmed
title: Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
source: Dev. Biol. 355:275-85
year: 2011

L-Tryptophan [ChEBI:16828]
type: SmallMoleculeReference
name: (S)-alpha-amino-beta-(3-indolyl)-propionic acid
name: L-Tryptophan
xref: UnificationXref2478

http://identifiers.org/pubmed/20301507
type: PublicationXref
id: 20301507
author: Stephens, K
author: Sparks, SE
author: Bird, TC
author: Pagon, RA
author: Dolan, CR
author: Krasnewich, DM
db: Pubmed
title: Congenital Disorders of Glycosylation Overview
year: 1993

http://identifiers.org/pubmed/11161786
type: PublicationXref
id: 11161786
author: Lee, A
author: Beck, L
author: Markovich, D
db: Pubmed
title: The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization
source: Genomics 70:354-63
year: 2000

inferred from electronic annotation
type: EvidenceCodeVocabulary
xref: UnificationXref29

http://identifiers.org/pubmed/17143292
type: PublicationXref
id: 17143292
author: Kimelman, D
author: Xu, W
db: Pubmed
title: beta-catenin destruction complex: insights and questions from a structural perspective
source: Oncogene 25:7482-91
year: 2006

http://identifiers.org/pubmed/13032008
type: PublicationXref
id: 13032008
author: Lipmann, F
db: Pubmed
title: On chemistry and function of coenzyme A
source: Bacteriol Rev 17:1-16
year: 1953

http://identifiers.org/pubmed/8394361
type: PublicationXref
id: 8394361
author: Kasama, T
author: Shimizu, T
author: Taketani, Y
author: Izumi, T
author: Takahashi, T
author: Kobayashi, Y
author: Yokomizo, T
author: Sato, F
db: Pubmed
title: Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase
source: J Biol Chem 268:18128-35
year: 1993

http://identifiers.org/pubmed/16297879
type: PublicationXref
id: 16297879
author: Cetin, I
author: Bolego, C
author: Radaelli, T
author: Folco, G
author: Sala, A
author: Buccellati, C
author: Puglisi, L
db: Pubmed
title: eNOS, COX-2, and prostacyclin production are impaired in endothelial cells from diabetics
source: Biochem Biophys Res Commun 339:188-90
year: 2006

UnificationXref1999
type: UnificationXref
id: 4230458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230458

UnificationXref1998
type: UnificationXref
id: 4230456
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230456

UnificationXref1995
type: UnificationXref
id: CHEBI:36319
db: ChEBI

UnificationXref1994
type: UnificationXref
id: 4230455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230455

UnificationXref1997
type: UnificationXref
id: REACT_9774
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9774.2

UnificationXref1996
type: UnificationXref
id: 189447
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189447

UnificationXref1991
type: UnificationXref
id: 189449
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189449

UnificationXref1990
type: UnificationXref
id: CHEBI:16645
db: ChEBI

UnificationXref1993
type: UnificationXref
id: P64341
db: UniProt

UnificationXref1992
type: UnificationXref
id: REACT_9601
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9601.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P99078
data source: Reactome
name: Phosphoglucose isomerase
name: NLK
name: PGI
name: SA-36
name: Sperm antigen-36
name: Neuroleukin
name: Glucose-6-phosphate isomerase
name: PHI
name: Phosphohexose isomerase
name: P99078
xref: UnificationXref54
feature: FragmentFeature5
cellular location: intracellular
comment: Reactome DB_ID: 4229791
display name: GPI

http://identifiers.org/pubmed/9686347
type: PublicationXref
id: 9686347
author: Vockley, JG
author: Cederbaum, SD
author: Kern, RM
author: Jenkinson, CP
author: Grody, WW
author: Iyer, RK
db: Pubmed
title: The human arginases and arginase deficiency
source: J Inherit Metab Dis 21:86-100
year: 1998

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7J4
data source: Reactome
name: 6PF-2-K/Fru- 2,6-P2ASE liver isozyme
name: PFKFB1(1-471)
name: Fructose-2,6-bisphosphatase
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
name: Q7A7J4
name: 6-phosphofructo-2-kinase
xref: UnificationXref68
feature: FragmentFeature6
cellular location: intracellular
comment: Reactome DB_ID: 4230065
display name: PFKFB1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A093
data source: Reactome
name: Nitric oxide synthase, inducible
name: P0A093
name: iNOS
xref: UnificationXref24
feature: FragmentFeature3
cellular location: intracellular
comment: Reactome DB_ID: 4230779
display name: NOS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A559
data source: Reactome
name: Pyruvate kinase, L isozyme
name: Q7A559
name: PKLR isoform 2
name: pyruvate kinase, liver and RBC
name: Red cell/liver pyruvate kinase
name: PKLR isozyme L
xref: UnificationXref38
feature: FragmentFeature4
cellular location: intracellular
comment: Reactome DB_ID: 4230026
display name: PKLR-2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A093
data source: Reactome
name: P0A093
name: NOS1_HUMAN
name: Nitric oxide synthase, brain
xref: UnificationXref22
feature: FragmentFeature1
cellular location: intracellular
comment: Reactome DB_ID: 4230778
display name: NOS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P0A093
data source: Reactome
name: NOS3(2-1203)
name: eNOS
name: Nitric oxide synthase, endothelial
name: P0A093
xref: UnificationXref23
feature: FragmentFeature2
cellular location: intracellular
comment: Reactome DB_ID: 4230610
display name: NOS3

http://identifiers.org/pubmed/22658984
type: PublicationXref
id: 22658984
author: Korenbrot, Juan I
db: Pubmed
title: Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models
source: Prog Retin Eye Res 31:442-66
year: 2012

http://identifiers.org/pubmed/8089153
type: PublicationXref
id: 8089153
author: Hirst, M
author: Lou, L
author: Nakamura, J
author: Haliday, E
db: Pubmed
title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
source: J Biol Chem 269:23830-23837
year: 1994

Nitric oxide synthase
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref25
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230780

UnificationXref1970
type: UnificationXref
id: REACT_118256
db: Reactome
id version: 7
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118256.7

UnificationXref1971
type: UnificationXref
id: 4231263
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231263

Metabolism of lipids and lipoproteins
type: Pathway
data source: Reactome
pathway component: Phospholipid metabolism
pathway component: REACT 142911.5
pathway component: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
pathway component: Sphingolipid metabolism
pathway component: REACT 84026.9
pathway component: Lipid digestion, mobilization, and transport
pathway component: Ubiquinol biosynthesis
pathway component: Arachidonic acid metabolism
pathway component: REACT 86890.9
pathway component: REACT 87163.9
evidence: Evidence95
xref: UnificationXref715
xref: UnificationXref714
pathway order: PathwayStep85
pathway order: PathwayStep53
pathway order: PathwayStep60
pathway order: PathwayStep57
pathway order: PathwayStep67
pathway order: PathwayStep91
pathway order: PathwayStep50
pathway order: PathwayStep70
pathway order: PathwayStep40
pathway order: PathwayStep88
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1972
type: UnificationXref
id: REACT_34326
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34326.10

6-Phospho-D-gluconate [ChEBI:16863]
type: SmallMoleculeReference
name: 6-Phospho-D-gluconate
xref: UnificationXref249

UnificationXref1973
type: UnificationXref
id: CHEBI:27889
db: ChEBI

UnificationXref1974
type: UnificationXref
id: 190173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190173

UnificationXref1975
type: UnificationXref
id: REACT_9737
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9737.2

UnificationXref1976
type: UnificationXref
id: P64334
db: UniProt

UnificationXref1977
type: UnificationXref
id: 4230473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230473

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7J4
data source: Reactome
name: 6- phosphofructo-2-kinase
name: iPFK-2
name: 6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
name: Fructose-2,6-bisphosphatase
name: Q7A7J4
xref: UnificationXref72
feature: FragmentFeature8
cellular location: intracellular
comment: Reactome DB_ID: 4230069
display name: PFKFB3

UnificationXref1978
type: UnificationXref
id: 4230474
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230474

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7J4
data source: Reactome
name: 6- phosphofructo-2-kinase
name: PFK-2/FBPase-2
name: 6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme
name: Fructose-2,6-bisphosphatase
name: Q7A7J4
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
xref: UnificationXref70
feature: FragmentFeature7
cellular location: intracellular
comment: Reactome DB_ID: 4230067
display name: PFKFB2

UnificationXref1979
type: UnificationXref
id: 4230485
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230485

http://identifiers.org/pubmed/17027300
type: PublicationXref
id: 17027300
author: Cresswell, P
author: Giodini, A
author: Ackerman, AL
db: Pubmed
title: A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells
source: Immunity 25:607-17
year: 2006

http://identifiers.org/pubmed/16551257
type: PublicationXref
id: 16551257
author: Cooper, MD
author: Pancer, Z
db: Pubmed
title: The evolution of adaptive immunity
source: Annu Rev Immunol 24:497-518
year: 2006

UnificationXref1981
type: UnificationXref
id: REACT_85040
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_85040.9

UnificationXref1982
type: UnificationXref
id: CHEBI:17549
db: ChEBI

UnificationXref1980
type: UnificationXref
id: 4230486
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230486

UnificationXref1985
type: UnificationXref
id: CHEBI:17381
db: ChEBI

UnificationXref1986
type: UnificationXref
id: 189464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189464

UnificationXref1983
type: UnificationXref
id: 189489
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189489

UnificationXref1984
type: UnificationXref
id: REACT_9717
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9717.2

UnificationXref1989
type: UnificationXref
id: REACT_87228
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87228.9

UnificationXref1987
type: UnificationXref
id: REACT_9816
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9816.2

UnificationXref1988
type: UnificationXref
id: 4230476
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230476

UnificationXref1959
type: UnificationXref
id: 4231131
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231131

UnificationXref1958
type: UnificationXref
id: MOD:00274
db: MOD

Pyruvate
type: SmallMoleculeReference
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
name: Pyruvate [ChEBI:32816]
xref: UnificationXref144

http://identifiers.org/pubmed/16720382
type: PublicationXref
id: 16720382
author: Maguire, ME
db: Pubmed
title: Magnesium transporters: properties, regulation and structure
source: Front Biosci 11:3149-63
year: 2006

UnificationXref1954
type: UnificationXref
id: REACT_117647
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_117647.1

UnificationXref1955
type: UnificationXref
id: Q7A894
db: UniProt

UnificationXref1956
type: UnificationXref
id: MOD:00798
db: MOD

UnificationXref1957
type: UnificationXref
id: 4231141
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231141

UnificationXref1950
type: UnificationXref
id: CHEBI:16136
db: ChEBI

UnificationXref1951
type: UnificationXref
id: 1614532
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614532

UnificationXref1952
type: UnificationXref
id: REACT_116358
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116358.1

UnificationXref1953
type: UnificationXref
id: 1614597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614597

Phosphopantetheine
type: SmallMoleculeReference
name: Pantetheine 4'-phosphate [ChEBI:16858]
name: 4'-Phosphopantetheine
name: Pantetheine 4'-phosphate
xref: UnificationXref1442

L-Threonine
type: SmallMoleculeReference
name: 2-Amino-3-hydroxybutyric acid
name: L-Threonine [ChEBI:6308]
xref: UnificationXref2590

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMoleculeReference
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
name: GSH
name: Glutathione [ChEBI:16856]
xref: UnificationXref592

UnificationXref1969
type: UnificationXref
id: 4231318
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231318

http://identifiers.org/pubmed/16807922
type: PublicationXref
id: 16807922
author: Hu, WS
author: Lee, MM
author: Hossler, P
author: Goh, LT
db: Pubmed
title: GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells
source: Biotechnol Bioeng 95:946-60
year: 2006

Pyruvate metabolism and Citric Acid (TCA) cycle
type: Pathway
data source: Reactome
pathway component: REACT 105136.9
pathway component: Citric acid cycle (TCA cycle)
pathway component: Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
evidence: Evidence118
xref: RelationshipXref131
xref: UnificationXref877
xref: UnificationXref876
pathway order: PathwayStep105
pathway order: PathwayStep114
pathway order: PathwayStep111
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref1960
type: UnificationXref
id: 113597
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113597

http://identifiers.org/pubmed/8656081
type: PublicationXref
id: 8656081
author: Hurt, E
author: Moore, SA
author: Yoder, E
author: Spector, AA
author: Sprecher, H
db: Pubmed
title: Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid
source: J Lipid Res 36:2433-43
year: 1995

UnificationXref1967
type: UnificationXref
id: 4231421
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231421

UnificationXref1968
type: UnificationXref
id: REACT_126330
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126330.5

UnificationXref1965
type: UnificationXref
id: 4231420
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231420

UnificationXref1966
type: UnificationXref
id: REACT_140675
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_140675.5

UnificationXref1963
type: UnificationXref
id: 4231144
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231144

UnificationXref1964
type: UnificationXref
id: REACT_131235
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_131235.5

UnificationXref1961
type: UnificationXref
id: REACT_3156
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3156.1

UnificationXref1962
type: UnificationXref
id: 4231142
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231142

http://identifiers.org/pubmed/20466922
type: PublicationXref
id: 20466922
author: Russell, DG
author: Barry CE, 3rd
author: Flynn, JL
db: Pubmed
title: Tuberculosis: what we don't know can, and does, hurt us
source: Science 328:852-6
year: 2010

http://identifiers.org/pubmed/17222168
type: PublicationXref
id: 17222168
author: Agre, P
author: Frøkiaer, J
author: Nielsen, S
author: Kwon, TH
db: Pubmed
title: Regulation and dysregulation of aquaporins in water balance disorders
source: J Intern Med 261:53-64
year: 2007

Catalysis195
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction204
control type: ACTIVATION
xref: RelationshipXref411
xref: RelationshipXref410
controller: YARS2 dimer (name copied from entity in Homo sapiens)

Catalysis194
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction203
control type: ACTIVATION
xref: RelationshipXref408
xref: RelationshipXref409
controller: P67593

Catalysis193
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction202
control type: ACTIVATION
xref: RelationshipXref407
xref: RelationshipXref406
controller: SARS2 dimer (name copied from entity in Homo sapiens)

Catalysis192
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction201
control type: ACTIVATION
xref: RelationshipXref405
xref: RelationshipXref404
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis199
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction208
control type: ACTIVATION
xref: RelationshipXref417
xref: RelationshipXref413
controller: Homologues of SLC9A9

Catalysis198
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction207
control type: ACTIVATION
xref: RelationshipXref416
xref: RelationshipXref413
controller: Na+/H+ exchanger proteins 7/8

Catalysis197
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction206
control type: ACTIVATION
xref: RelationshipXref415
xref: RelationshipXref413
controller: Homologues of SLC9A6

Catalysis196
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction205
control type: ACTIVATION
xref: RelationshipXref414
xref: RelationshipXref413
controller: Na+/H+ exchanger proteins

http://identifiers.org/pubmed/7510718
type: PublicationXref
id: 7510718
author: Ishibashi, K
author: Fushimi, K
author: Saito, F
author: Inui, K
author: Nakajima, K
author: Uchida, S
author: Saito, H
author: Ikeuchi, T
author: Kuwahara, M
author: Sasaki, S
db: Pubmed
title: Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct
source: J Clin Invest 93:1250-6
year: 1994

Catalysis190
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction199
control type: ACTIVATION
xref: RelationshipXref401
xref: RelationshipXref400
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis191
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction200
control type: ACTIVATION
xref: RelationshipXref403
xref: RelationshipXref402
controller: P68848

http://identifiers.org/pubmed/4349867
type: PublicationXref
id: 4349867
author: Niedel, J
author: Dietrich, LS
db: Pubmed
title: Nicotinate phosphoribosyltransferase of human erythrocytes. Purification and properties.
source: J Biol Chem 248:3500-5
year: 1973

Catalysis189
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction198
control type: ACTIVATION
xref: RelationshipXref399
xref: RelationshipXref398
controller: KARS dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/16125937
type: PublicationXref
id: 16125937
author: Ewalt, KL
author: Kim, S
author: Park, SG
db: Pubmed
title: Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers
source: Trends Biochem Sci 30:569-74
year: 2005

Catalysis182
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction191
control type: ACTIVATION
xref: RelationshipXref385
xref: RelationshipXref384
controller: GARS dimer (name copied from entity in Homo sapiens)

http://identifiers.org/pubmed/8621661
type: PublicationXref
id: 8621661
author: Hu, CA
author: Valle, D
author: Lin, WW
db: Pubmed
title: Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase
source: J Biol Chem 271:9795-800
year: 1996

Catalysis181
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction190
control type: ACTIVATION
xref: RelationshipXref381
xref: RelationshipXref374
controller: Astrocytic EAATs

Catalysis184
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction193
control type: ACTIVATION
xref: RelationshipXref390
xref: RelationshipXref389
controller: DARS2 dimer (name copied from entity in Homo sapiens)

Catalysis183
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction192
control type: ACTIVATION
xref: RelationshipXref388
xref: RelationshipXref387
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis186
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction195
control type: ACTIVATION
xref: RelationshipXref393
xref: RelationshipXref384
controller: GARS dimer (name copied from entity in Homo sapiens)

Catalysis185
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction194
control type: ACTIVATION
xref: RelationshipXref391
xref: RelationshipXref392
controller: Note: the coordinates are copied over from Homo sapiens.

Catalysis188
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction197
control type: ACTIVATION
xref: RelationshipXref396
xref: RelationshipXref397
controller: P67513

Catalysis187
type: Catalysis
data source: Reactome
controlled: BiochemicalReaction196
control type: ACTIVATION
xref: RelationshipXref395
xref: RelationshipXref394
controller: P67509

all-trans-Retinene
type: SmallMoleculeReference
name: all-trans-Vitamin A aldehyde
name: Retinal [ChEBI:17898]
name: Retinene
name: Vitamin A aldehyde
name: Retinal
name: all-trans-Retinal
xref: UnificationXref2240

L-Tyrosine [ChEBI:17895]
type: SmallMoleculeReference
name: (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
name: L-Tyrosine
name: (S)-3-(p-Hydroxyphenyl)alanine
xref: UnificationXref1730

2-Oxoadipate
type: SmallMoleculeReference
name: 2-Oxoadipate [ChEBI:15753]
name: 2-Oxoadipic acid
xref: UnificationXref1705

http://identifiers.org/pubmed/12151341
type: PublicationXref
id: 12151341
author: Takamori, S
author: Malherbe, P
author: Jahn, R
author: Broger, C
db: Pubmed
title: Molecular cloning and functional characterization of human vesicular glutamate transporter 3
source: EMBO Rep 3:798-803
year: 2002

http://identifiers.org/pubmed/11479594
type: PublicationXref
id: 11479594
author: Westaway, SK
author: Johnson, MA
author: Levinson, B
author: Zhou, B
author: Hayflick, SJ
author: Gitschier, J
db: Pubmed
title: A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
source: Nat Genet 28:345-9
year: 2001

http://identifiers.org/pubmed/165196
type: PublicationXref
id: 165196
author: Forman, JH
author: Kennedy, J
db: Pubmed
title: Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid.
source: J Biol Chem 250:4322-6
year: 1975

beta-Nicotinate D-ribonucleotide
type: SmallMoleculeReference
name: Nicotinate D-ribonucleotide [ChEBI:7561]
name: Nicotinic acid ribonucleotide
name: Nicotinate ribonucleotide
name: Nicotinate D-ribonucleotide
xref: UnificationXref1482

Zinc transporters
type: Pathway
data source: Reactome
pathway component: Zinc efflux and compartmentalization by the SLC30 family
evidence: Evidence384
xref: UnificationXref2800
xref: UnificationXref2799
pathway order: PathwayStep374
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

(R)-4'-Phosphopantothenoyl-L-cysteine [ChEBI:328]
type: SmallMoleculeReference
name: (R)-4'-Phosphopantothenoyl-L-cysteine
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
xref: UnificationXref1439

http://identifiers.org/pubmed/16601864
type: PublicationXref
id: 16601864
author: Struys, EA
db: Pubmed
title: D-2-Hydroxyglutaric aciduria: unravelling the biochemical pathway and the genetic defect
source: J Inherit Metab Dis 29:21-9
year: 2006

http://identifiers.org/pubmed/18767960
type: PublicationXref
id: 18767960
author: Antonellis, A
author: Green, ED
db: Pubmed
title: The role of aminoacyl-tRNA synthetases in genetic diseases
source: Annu Rev Genomics Hum Genet 9:87-107
year: 2008

http://identifiers.org/pubmed/16819626
type: PublicationXref
id: 16819626
author: Becherer, U
author: Rettig, J
db: Pubmed
title: Vesicle pools, docking, priming, and release
source: Cell Tissue Res 326:393-407
year: 2006

http://identifiers.org/pubmed/8063828
type: PublicationXref
id: 8063828
author: Frigeri, A
author: Ma, T
author: Verkman, AS
author: Hasegawa, H
db: Pubmed
title: Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter
source: J Biol Chem 269:21845-9
year: 1994

http://identifiers.org/pubmed/2995985
type: PublicationXref
id: 2995985
author: Evans, DR
author: Kelly, RE
author: Pastra-Landis, SC
author: Lee, L
db: Pubmed
title: Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells
source: Proc Natl Acad Sci USA 82:6802-6806
year: 1985

FADH2
type: SmallMoleculeReference
name: FADH2 [ChEBI:17877]
xref: UnificationXref397

Ethylenesuccinic acid
type: SmallMoleculeReference
name: Butanedionic acid
name: Succinate [ChEBI:15741]
name: Succinate
name: Succinic acid
xref: UnificationXref2747

http://identifiers.org/pubmed/1590793
type: PublicationXref
id: 1590793
author: Waltenberger, J
author: Usuki, K
author: Heldin, CH
author: Pierce, G
author: Thomason, A
author: Miyazono, K
author: Saras, J
db: Pubmed
title: Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
source: Biochem Biophys Res Commun 184:1311-6
year: 1992

2-Aminomuconate semialdehyde [ChEBI:15745]
type: SmallMoleculeReference
name: 2-Aminomuconate 6-semialdehyde
name: 2-Aminomuconate semialdehyde
xref: UnificationXref1757

triglyceride
type: SmallMoleculeReference
name: triacylglycerol
name: ChEBI:17855 triacylglycerol
xref: UnificationXref352

uridine 5'-triphosphate
type: SmallMoleculeReference
name: Uridine triphosphate
name: UTP
name: UTP [ChEBI:15713]
xref: UnificationXref1320

Glutathione disulfide
type: SmallMoleculeReference
name: Oxidized glutathione [ChEBI:17858]
name: GSSG
name: Oxidized glutathione
xref: UnificationXref595

http://identifiers.org/pubmed/8200987
type: PublicationXref
id: 8200987
author: Rabier, D
author: Poggi-Bach, J
author: Rötig, A
author: Munnich, A
author: Landrieu, P
author: Doonan, S
author: Letouzé, P
author: Rustin, P
author: Chretien, D
author: Bourgeron, T
db: Pubmed
title: Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
source: J Clin Invest 93:2514-2518
year: 1994

http://identifiers.org/pubmed/8114698
type: PublicationXref
id: 8114698
author: Nevins, JR
author: Ohtani, K
db: Pubmed
title: Functional properties of a Drosophila homolog of the E2F1 gene
source: Mol Cell Biol 14:1603-12
year: 1994

Heme biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction168
pathway component: BiochemicalReaction169
pathway component: BiochemicalReaction167
pathway component: BiochemicalReaction165
pathway component: BiochemicalReaction164
pathway component: BiochemicalReaction170
pathway component: BiochemicalReaction171
pathway component: BiochemicalReaction166
evidence: Evidence268
xref: UnificationXref2061
xref: RelationshipXref339
xref: UnificationXref2060
pathway order: PathwayStep258
pathway order: PathwayStep261
pathway order: PathwayStep259
pathway order: PathwayStep263
pathway order: PathwayStep257
pathway order: PathwayStep264
pathway order: PathwayStep262
pathway order: PathwayStep260
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

taurolithocholic acid sulfate
type: SmallMoleculeReference
name: taurolithocholic acid sulfate [ChEBI:17864]
xref: UnificationXref2724

2-Oxoisocaproate
type: SmallMoleculeReference
name: 4-Methyl-2-oxopentanoate
name: 4-Methyl-2-oxopentanoate [ChEBI:17865]
xref: UnificationXref1632

3-Dehydrosphinganine
type: SmallMoleculeReference
name: 3-Dehydrosphinganine [ChEBI:1489]
name: 3-Dehydro-D-sphinganine
xref: UnificationXref662

(S)-2,5-Diaminopentanoate
type: SmallMoleculeReference
name: (S)-2,5-Diaminopentanoic acid
name: (S)-2,5-diaminovaleric acid
name: L-Ornithine [ChEBI:15729]
name: L-Ornithine
xref: UnificationXref1603

dhk-PGE2/F2a
type: SmallMolecule
data source: Reactome
member physical entity: dhk-PGE2
member physical entity: dhk-PGF2a
xref: UnificationXref571
xref: UnificationXref572
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2161684

http://identifiers.org/pubmed/1559981
type: PublicationXref
id: 1559981
author: Dupret, JM
author: Grant, DM
db: Pubmed
title: Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.
source: J Biol Chem 267:7381-5
year: 1992

15k-PGF2a
type: SmallMolecule
entity reference: 15-Keto-PGF2a
data source: Reactome
xref: UnificationXref562
xref: UnificationXref561
cellular location: cytosol
comment: Reactome DB_ID: 2142799

15k-PGE2
type: SmallMolecule
entity reference: (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
data source: Reactome
xref: UnificationXref559
xref: UnificationXref558
cellular location: cytosol
comment: Reactome DB_ID: 2142721

15k-PGE2/F2a
type: SmallMolecule
data source: Reactome
member physical entity: 15k-PGF2a
member physical entity: 15k-PGE2
xref: UnificationXref563
xref: UnificationXref564
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 2161650

12-oxoLTB4
type: SmallMolecule
entity reference: 12-Keto-leukotriene B4
data source: Reactome
xref: UnificationXref583
xref: UnificationXref584
cellular location: cytosol
comment: Reactome DB_ID: 2142810

Leukotriene-B(4) omega-hydroxylase
type: SmallMolecule
entity reference: Leukotriene B4
data source: Reactome
name: Leukotriene B4
name: Leukotriene-B(4) 20-monooxygenase
xref: UnificationXref580
xref: UnificationXref581
cellular location: cytosol
comment: Reactome DB_ID: 266056
display name: LTB4

dhk-PGF2a
type: SmallMolecule
entity reference: CHEBI:63976
data source: Reactome
xref: UnificationXref569
xref: UnificationXref570
cellular location: cytosol
comment: Reactome DB_ID: 2142751

dhk-PGE2
type: SmallMolecule
entity reference: (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate
data source: Reactome
xref: UnificationXref567
xref: UnificationXref566
cellular location: cytosol
comment: Reactome DB_ID: 2142749

http://identifiers.org/pubmed/16990140
type: PublicationXref
id: 16990140
author: Dai, H
author: Sudhof, TC
author: Maximov, A
author: Tang, J
author: Rizo, J
author: Shin, OH
db: Pubmed
title: A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
source: Cell 126:1175-87
year: 2006

UniProt:Q99XE9
type: ProteinReference
xref: UnificationXref1083
organism: BioSource1

(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
type: SmallMolecule
entity reference: 5-HPETE
data source: Reactome
xref: UnificationXref590
xref: UnificationXref591
cellular location: cytosol
comment: Reactome DB_ID: 266010
display name: 5S-HpETE

UnificationXref2028
type: UnificationXref
id: REACT_9585
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9585.2

UnificationXref2027
type: UnificationXref
id: 189463
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189463

UnificationXref2029
type: UnificationXref
id: 189481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189481

Sodium-coupled phosphate cotransporters
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction211
pathway component: REACT 91835.9
evidence: Evidence351
xref: UnificationXref2583
xref: UnificationXref2582
pathway order: PathwayStep341
pathway order: PathwayStep340
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2020
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

S-Adenosyl-L-homocysteine
type: SmallMoleculeReference
name: S-Adenosyl-L-homocysteine [ChEBI:16680]
name: S-Adenosylhomocysteine
xref: UnificationXref705

UnificationXref2022
type: UnificationXref
id: REACT_9648
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9648.2

UnificationXref2021
type: UnificationXref
id: 189461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189461

gamma-L-Glutamyl-L-cysteinyl-glycine
type: SmallMolecule
entity reference: gamma-L-Glutamyl-L-cysteinyl-glycine
data source: Reactome
name: 5-L-Glutamyl-L-cysteinylglycine
name: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
name: Reduced glutathione
name: Glutathione
xref: UnificationXref594
xref: UnificationXref593
cellular location: cytosol
comment: Reactome DB_ID: 29450
display name: GSH

UnificationXref2024
type: UnificationXref
id: 189478
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189478

glutathione disulfide
type: SmallMolecule
entity reference: Glutathione disulfide
data source: Reactome
name: oxidized glutathione
xref: UnificationXref596
xref: UnificationXref597
cellular location: cytosol
comment: Reactome DB_ID: 111745
display name: GSSG

UnificationXref2023
type: UnificationXref
id: CHEBI:15435
db: ChEBI

UnificationXref2026
type: UnificationXref
id: CHEBI:15430
db: ChEBI

UnificationXref2025
type: UnificationXref
id: REACT_9886
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9886.2

http://identifiers.org/pubmed/2340091
type: PublicationXref
id: 2340091
author: McBride, W
author: Blum, M
author: Heim, M
author: Grant, DM
author: Meyer, UA
db: Pubmed
title: Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression
source: DNA Cell Biol 9:193-203
year: 1990

UnificationXref2040
type: UnificationXref
id: 113531
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113531

UnificationXref2039
type: UnificationXref
id: REACT_9665
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9665.2

UnificationXref2038
type: UnificationXref
id: 189487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189487

Uridine 5'-monophosphate
type: SmallMoleculeReference
name: Uridine monophosphate
name: UMP [ChEBI:16695]
name: Uridylic acid
name: UMP
name: 5'Uridylic acid
xref: UnificationXref1164

UnificationXref2033
type: UnificationXref
id: Q7A4W4
db: UniProt

UnificationXref2032
type: UnificationXref
id: REACT_9839
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9839.1

UnificationXref2031
type: UnificationXref
id: 189484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189484

UnificationXref2030
type: UnificationXref
id: REACT_9751
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9751.1

UnificationXref2037
type: UnificationXref
id: REACT_98849
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98849.9

UnificationXref2036
type: UnificationXref
id: 4230464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230464

UnificationXref2035
type: UnificationXref
id: 4230462
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230462

Prostaglandin F2alpha
type: SmallMolecule
entity reference: Prostaglandin F2a
data source: Reactome
xref: UnificationXref551
xref: UnificationXref552
cellular location: cytosol
comment: Reactome DB_ID: 879535
display name: PGF2a

UnificationXref2034
type: UnificationXref
id: 4230461
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230461

S-adenosyl-L-methionine
type: SmallMolecule
entity reference: S-Adenosyl-L-methionine [ChEBI:15414]
data source: Reactome
xref: UnificationXref699
xref: UnificationXref698
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162265

MDMQ10H2
type: SmallMolecule
entity reference: 2-methoxy-6-decaprenyl-1,4-benzoquinol [ChEBI:64180]
data source: Reactome
xref: UnificationXref695
xref: UnificationXref696
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162205

magnesium
type: SmallMolecule
entity reference: CHEBI:18420
data source: Reactome
name: Mg++
xref: UnificationXref688
xref: UnificationXref687
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 109496
display name: Mg2+

diphosphate
type: SmallMolecule
entity reference: CHEBI:29888
data source: Reactome
name: pyrophosphoric acid
name: pyrophosphate
xref: UnificationXref684
xref: UnificationXref683
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 159450
display name: PPi

all-E-10PrP2
type: SmallMolecule
entity reference: CHEBI:61011
data source: Reactome
xref: UnificationXref681
xref: UnificationXref682
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162214

IPPP
type: SmallMolecule
entity reference: delta3-methyl-3-butenyl diphosphate
data source: Reactome
xref: UnificationXref679
xref: UnificationXref678
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162256

UnificationXref619
type: UnificationXref
id: CHEBI:15558
db: ChEBI

FPP
type: SmallMolecule
entity reference: CHEBI:17407
data source: Reactome
xref: UnificationXref677
xref: UnificationXref676
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162257

UnificationXref618
type: UnificationXref
id: REACT_152325
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152325.1

UnificationXref617
type: UnificationXref
id: 2142718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142718

UnificationXref616
type: UnificationXref
id: CHEBI:15628
db: ChEBI

UnificationXref615
type: UnificationXref
id: REACT_153499
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153499.3

UnificationXref614
type: UnificationXref
id: 4231435
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231435

http://identifiers.org/pubmed/19304569
type: PublicationXref
id: 19304569
author: Pineda, M
author: Palau, F
author: Martínez-Rubio, D
author: Espinós, C
author: Lupo, V
author: Ormazabal, A
author: Spaapen, LJ
author: Vilaseca, MA
author: Artuch, R
db: Pubmed
title: Mutations in the urocanase gene UROC1 are associated with urocanic aciduria
source: J Med Genet 46:407-11
year: 2009

UnificationXref613
type: UnificationXref
id: REACT_157658
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157658.3

UnificationXref612
type: UnificationXref
id: 4231186
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231186

UnificationXref611
type: UnificationXref
id: 4231184
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231184

UnificationXref610
type: UnificationXref
id: 4231178
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231178

http://identifiers.org/pubmed/15581364
type: PublicationXref
id: 15581364
author: Zhai, H
author: McLafferty, FW
author: Brand, LA
author: Begley, TP
author: Strauss, E
db: Pubmed
title: Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
source: Biochemistry 43:15520-33
year: 2004

UnificationXref2009
type: UnificationXref
id: 4230468
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230468

UnificationXref2006
type: UnificationXref
id: REACT_9699
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9699.3

UnificationXref2005
type: UnificationXref
id: 189455
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189455

UnificationXref2008
type: UnificationXref
id: 4230467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230467

UnificationXref2007
type: UnificationXref
id: P67420
db: UniProt

S-adenosyl-L-homocysteine
type: SmallMolecule
entity reference: S-Adenosyl-L-homocysteine
data source: Reactome
xref: UnificationXref706
xref: UnificationXref707
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162252

UnificationXref2002
type: UnificationXref
id: 189407
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189407

myristoyl-CoA
type: SmallMolecule
entity reference: Myristoyl-CoA
data source: Reactome
xref: UnificationXref722
xref: UnificationXref721
cellular location: cytosol
comment: Reactome DB_ID: 184174
display name: MYS-CoA

UnificationXref2001
type: UnificationXref
id: CHEBI:15437
db: ChEBI

H+
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref700
xref: UnificationXref701
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113529

UnificationXref2004
type: UnificationXref
id: CHEBI:15439
db: ChEBI

DMQ10H2
type: SmallMolecule
entity reference: 6-methoxy-3-methyl-2-decaprenyl-1,4-benzoquinol [ChEBI:64181]
data source: Reactome
xref: UnificationXref704
xref: UnificationXref703
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 2162204

UnificationXref2003
type: UnificationXref
id: REACT_9722
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9722.2

UnificationXref2000
type: UnificationXref
id: REACT_114418
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114418.8

12S-HpETE
type: SmallMolecule
entity reference: (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoate
data source: Reactome
xref: UnificationXref640
xref: UnificationXref641
cellular location: cytosol
comment: Reactome DB_ID: 2142811

12R-HETE
type: SmallMolecule
entity reference: 12(R)-hydroxyeicosatetraenoic acid
data source: Reactome
xref: UnificationXref635
xref: UnificationXref636
cellular location: cytosol
comment: Reactome DB_ID: 2142716

15-oxo-LXA4
type: SmallMolecule
entity reference: CHEBI:63992
data source: Reactome
name: 15-keto-LXA4
xref: UnificationXref651
xref: UnificationXref650
cellular location: cytosol
comment: Reactome DB_ID: 2142761
display name: 15k-LXA4

12S-HETE
type: SmallMolecule
entity reference: 12(S)-hydroxyeicosatetraenoic acid
data source: Reactome
xref: UnificationXref643
xref: UnificationXref644
cellular location: cytosol
comment: Reactome DB_ID: 2142678

15S-HpETE
type: SmallMolecule
entity reference: 15-Hydroperoxyicosatetraenoic acid
data source: Reactome
xref: UnificationXref617
xref: UnificationXref618
cellular location: cytosol
comment: Reactome DB_ID: 2142718

UnificationXref608
type: UnificationXref
id: 4231176
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231176

UnificationXref607
type: UnificationXref
id: 4230044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230044

5S-HETE
type: SmallMolecule
entity reference: CHEBI:28209
data source: Reactome
xref: UnificationXref600
xref: UnificationXref599
cellular location: cytosol
comment: Reactome DB_ID: 2142733

12R-HpETE
type: SmallMolecule
entity reference: (5Z,8Z,10E,14Z)-(12R)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoic acid
data source: Reactome
xref: UnificationXref632
xref: UnificationXref633
cellular location: cytosol
comment: Reactome DB_ID: 2142790

15S-HETE
type: SmallMolecule
entity reference: (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
data source: Reactome
xref: UnificationXref621
xref: UnificationXref620
cellular location: cytosol
comment: Reactome DB_ID: 2142707

UnificationXref609
type: UnificationXref
id: 4231177
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231177

UnificationXref604
type: UnificationXref
id: P99097
db: UniProt

http://identifiers.org/pubmed/8050359
type: PublicationXref
id: 8050359
author: Duronio, RJ
author: O'Farrell, PH
db: Pubmed
title: Developmental control of a G1-S transcriptional program in Drosophila
source: Development 120:1503-15
year: 1994

UnificationXref603
type: UnificationXref
id: 4230038
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230038

UnificationXref606
type: UnificationXref
id: 4230043
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230043

UnificationXref605
type: UnificationXref
id: 4230042
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230042

UnificationXref600
type: UnificationXref
id: REACT_151106
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151106.1

UnificationXref602
type: UnificationXref
id: MOD:00031
db: MOD

UnificationXref601
type: UnificationXref
id: Q7A391
db: UniProt

http://identifiers.org/pubmed/10522552
type: PublicationXref
id: 10522552
author: Ponka, P
db: Pubmed
title: Cell biology of heme
source: Am J Med Sci 318:241-56
year: 1999

UnificationXref2019
type: UnificationXref
id: REACT_89025
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_89025.9

http://identifiers.org/pubmed/17513417
type: PublicationXref
id: 17513417
author: Wang, Y
author: Tajkhorshid, E
db: Pubmed
title: Molecular mechanisms of conduction and selectivity in aquaporin water channels
source: J Nutr 137:1509S-1515S
year: 2007

UnificationXref2018
type: UnificationXref
id: 4230487
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230487

UnificationXref2017
type: UnificationXref
id: REACT_9818
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9818.3

UnificationXref2016
type: UnificationXref
id: 190128
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190128

UnificationXref2015
type: UnificationXref
id: CHEBI:28607
db: ChEBI

dhk-LXA4
type: SmallMolecule
entity reference: CHEBI:63993
data source: Reactome
xref: UnificationXref653
xref: UnificationXref654
cellular location: cytosol
comment: Reactome DB_ID: 2142690

UnificationXref2014
type: UnificationXref
id: REACT_9880
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9880.2

3-dehydrosphinganine
type: SmallMolecule
entity reference: 3-Dehydrosphinganine
data source: Reactome
xref: UnificationXref663
xref: UnificationXref664
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 428182
display name: 3-ketosphinganine

UnificationXref2013
type: UnificationXref
id: 190157
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190157

sphinganine
type: SmallMolecule
entity reference: 2-Amino-1,3-dihydroxyoctadecane
data source: Reactome
name: dihydrosphingosine
xref: UnificationXref666
xref: UnificationXref667
cellular location: endoplasmic reticulum membrane
comment: Reactome DB_ID: 428163
display name: SPA

UnificationXref2012
type: UnificationXref
id: CHEBI:28766
db: ChEBI

UnificationXref2011
type: UnificationXref
id: REACT_105404
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105404.9

UnificationXref2010
type: UnificationXref
id: 4230470
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230470

http://identifiers.org/pubmed/3435492
type: PublicationXref
id: 3435492
author: Li, SS
author: Pan, YC
author: Sakai, I
author: Sharief, FS
db: Pubmed
title: The cDNA and protein sequences of human lactate dehydrogenase B
source: Biochem J 248:933-6
year: 1987

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5K6
data source: Reactome
name: Q7A5K6
name: Endonuclease III-like protein 1 (EC 4.2.99.18)
name: hNTH1
name: Endonuclease III-like protein 1
xref: UnificationXref3096
feature: FragmentFeature260
cellular location: intracellular
comment: Reactome DB_ID: 4230315
display name: NTHL1

6-O- methylguanine-DNA methyltransferase
type: Protein
entity reference: Q7A3F5
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Methylated-DNA--protein-cysteine methyltransferase
name: Q7A3F5
name: Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase)
xref: UnificationXref3142
feature: FragmentFeature261
cellular location: intracellular
comment: Reactome DB_ID: 4230217
display name: MGMT

3-alkyladenine DNA glycosylase
type: Protein
entity reference: UniProt:P65415
data source: Reactome
name: ADPG
name: Note: the coordinates are copied over from Homo sapiens.
name: P65415
name: DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (ADPG) (3-alkyladenine DNA glycosylase) (N-methylpurine- DNA glycosirase)
name: 3-methyladenine DNA glycosidase
name: MPG glycosylase
name: N-methylpurine- DNA glycosirase
name: DNA-3-methyladenine glycosylase
xref: UnificationXref3049
feature: FragmentFeature258
cellular location: intracellular
comment: Reactome DB_ID: 4230345
display name: MPG

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4T1
data source: Reactome
name: Q7A4T1
name: MYH glycosylase
xref: UnificationXref3063
feature: FragmentFeature259
cellular location: intracellular
comment: Reactome DB_ID: 4230339
display name: MUTYH

6-O- methylguanine-DNA methyltransferase
type: Protein
entity reference: Q7A3F5
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: MGMT containing S-methyl-L-cysteine
name: Methylated-DNA--protein-cysteine methyltransferase
name: MetC-MGMT
xref: UnificationXref3145
feature: FragmentFeature262
feature: ModificationFeature22
cellular location: intracellular
comment: Reactome DB_ID: 4230220
display name: Q7A3F5

UnificationXref2071
type: UnificationXref
id: 4230049
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230049

UnificationXref2070
type: UnificationXref
id: Q7A7V4
db: UniProt

UnificationXref2073
type: UnificationXref
id: 4230051
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230051

UnificationXref2072
type: UnificationXref
id: 4230050
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230050

UniProt:P63645
type: ProteinReference
xref: UnificationXref1804
organism: BioSource1

UnificationXref2063
type: UnificationXref
id: REACT_91680
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91680.9

UnificationXref2064
type: UnificationXref
id: CHEBI:16236
db: ChEBI

UnificationXref2065
type: UnificationXref
id: 30203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30203

UnificationXref2066
type: UnificationXref
id: REACT_4353
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4353.2

UnificationXref2067
type: UnificationXref
id: CHEBI:15343
db: ChEBI

UnificationXref2068
type: UnificationXref
id: 29510
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29510

UnificationXref2069
type: UnificationXref
id: REACT_3097
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3097.2

Signaling by Wnt
type: Pathway
data source: Reactome
pathway component: REACT 166683.1
evidence: Evidence301
xref: UnificationXref2238
xref: UnificationXref2239
pathway order: PathwayStep295
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A4A4
data source: Reactome
name: UDP-N-acetylhexosamine pyrophosphorylase
name: Q7A4A4
name: UAP1_HUMAN
xref: UnificationXref2981
feature: FragmentFeature254
cellular location: intracellular
comment: Reactome DB_ID: 4230949
display name: UAP1

Hydroxymethylbilane [ChEBI:5809]
type: SmallMoleculeReference
name: Hydroxymethylbilane
xref: UnificationXref1990

L-2-Amino-4methylthiobutyric acid
type: SmallMoleculeReference
name: L-Methionine
name: L-Methionine [ChEBI:16643]
xref: UnificationXref1561

Ribonucleotide reductase small chain
type: Protein
entity reference: Q7A6T1
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Ribonucleoside-diphosphate reductase M2 chain
name: Q7A6T1
xref: UnificationXref3029
feature: FragmentFeature257
cellular location: intracellular
comment: Reactome DB_ID: 4231014
display name: RRM2

E2F1 targets
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Ribonucleotide reductase small chain
xref: UnificationXref3030
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231015

Q7A708
type: Protein
entity reference: Q7A708
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: TAP1_HUMAN
name: Antigen peptide transporter 1
xref: UnificationXref3012
feature: FragmentFeature256
cellular location: intracellular
comment: Reactome DB_ID: 4231088
display name: TAP1

Q7A708
type: Protein
entity reference: Q7A708
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: TAP2_HUMAN
name: Antigen peptide transporter 2
xref: UnificationXref3011
feature: FragmentFeature255
cellular location: intracellular
comment: Reactome DB_ID: 4231089
display name: TAP2

UnificationXref2080
type: UnificationXref
id: 4230059
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230059

UnificationXref2084
type: UnificationXref
id: REACT_4732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4732.2

UnificationXref2083
type: UnificationXref
id: 113539
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113539

UnificationXref2082
type: UnificationXref
id: CHEBI:15366
db: ChEBI

UnificationXref2081
type: UnificationXref
id: REACT_158477
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158477.3

UnificationXref2076
type: UnificationXref
id: 4230054
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230054

UnificationXref2077
type: UnificationXref
id: 4230055
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230055

UnificationXref2074
type: UnificationXref
id: 4230052
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230052

UnificationXref2075
type: UnificationXref
id: 4230053
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230053

UnificationXref2078
type: UnificationXref
id: 4230056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230056

UnificationXref2079
type: UnificationXref
id: 4230057
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230057

UnificationXref2051
type: UnificationXref
id: 391232
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=391232

UnificationXref2050
type: UnificationXref
id: 4230484
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230484

UnificationXref2045
type: UnificationXref
id: 4230479
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230479

UnificationXref2046
type: UnificationXref
id: 4230480
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230480

UnificationXref2047
type: UnificationXref
id: 4230481
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230481

UnificationXref2048
type: UnificationXref
id: 4230483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230483

UnificationXref2041
type: UnificationXref
id: REACT_4623
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4623.2

UnificationXref2042
type: UnificationXref
id: 189444
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189444

UnificationXref2043
type: UnificationXref
id: REACT_9617
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9617.1

UnificationXref2044
type: UnificationXref
id: P64125
db: UniProt

intracellular
type: CellularLocationVocabulary
xref: UnificationXref20

UnificationXref2049
type: UnificationXref
id: REACT_93298
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93298.9

UnificationXref2062
type: UnificationXref
id: 4231321
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231321

UnificationXref2061
type: UnificationXref
id: REACT_96932
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_96932.9

http://identifiers.org/pubmed/18768791
type: PublicationXref
id: 18768791
author: Horsefield, R
author: Neutze, R
author: Nordén, K
author: Törnroth-Horsefield, S
author: Johanson, U
author: Terwisscha van Scheltinga, AC
author: Kvassman, J
author: Fellert, M
author: Kjellbom, P
author: Backmark, A
db: Pubmed
title: High-resolution x-ray structure of human aquaporin 5
source: Proc Natl Acad Sci U S A 105:13327-32
year: 2008

Neurotransmitter Release Cycle
type: Pathway
data source: Reactome
pathway component: Acetylcholine Neurotransmitter Release Cycle
pathway component: REACT 112750.8
evidence: Evidence317
xref: UnificationXref2309
xref: UnificationXref2310
xref: RelationshipXref379
pathway order: PathwayStep307
pathway order: PathwayStep309
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2060
type: UnificationXref
id: 4231320
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231320

http://identifiers.org/pubmed/7706277
type: PublicationXref
id: 7706277
author: Lou, L
author: Nakamura, J
db: Pubmed
title: Biochemical characterization of human GMP synthetase
source: J Biol Chem 270:7347-7353
year: 1995

UnificationXref2058
type: UnificationXref
id: 4231249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231249

UnificationXref2059
type: UnificationXref
id: REACT_166592
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_166592.1

UnificationXref2056
type: UnificationXref
id: Q7A664
db: UniProt

UnificationXref2057
type: UnificationXref
id: 4231247
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231247

UnificationXref2054
type: UnificationXref
id: 2995328
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2995328

UnificationXref2055
type: UnificationXref
id: REACT_165517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_165517.1

UnificationXref2052
type: UnificationXref
id: REACT_17066
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17066.2

UnificationXref2053
type: UnificationXref
id: CHEBI:24480
db: ChEBI

Evidence202
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9990024
comment: Gephyrin, which stabilizes receptors on neuronal membranes, also catalyzes the transfer of a molybdenum ion onto the cofactor. The mechanism was elucidated in plants but, as the pathway is highly conserved, human gephyrin can complement missing plant proteins. Doubts remain about the actual molybdenum donor, probably molybdate, and whether a copper ion is possibly bound and removed (Stallmeyer et al, 1999).

Evidence203
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19675644
xref: http://identifiers.org/pubmed/16261263
comment: Molybdenum cofactor (MoCo) is needed by three enzymes in humans: sulfite oxidase, xanthine oxidase and aldehyde oxidase. The pathway of its synthesis is so conserved that plants and bacteria can readily use human enzymes. Bacteria, however, diverge after the first three steps from this path and their final MoCo differs from that of the eukaryotes. Plants and animals have also developed a refinement of their MoCo which is needed for the function of their xanthine and aldehyde oxidases. This means, in humans we find sulfurated instead of desulfurated molybdenum cofactor on these two enzymes (Schwarz 2005; Schwarz, Mendel, Ribbe 2009).

UnificationXref670
type: UnificationXref
id: REACT_144131
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144131.5

Evidence200
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11891227
xref: http://identifiers.org/pubmed/15180982
comment: GTP cyclizes in a reaction involving radicals of S-adenosylmethionine, catalyzed by the iron-sulfur cluster dimeric MOCS1. The intermediate result is called precursor Z (Hanzelmann et al, 2002; Hanzelmann et al, 2004).

UnificationXref671
type: UnificationXref
id: 4231377
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231377

Evidence201
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12571226
xref: http://identifiers.org/pubmed/12732628
comment: After the MOCS2A dimer is loaded with two sulfur atoms, their sequential deposition on the precursor Z molecule, with ring cleavage, is catalyzed by the MOCS2B half of the MOCS2 tetramer (Leimkuhler et al, 2003; Wuebbens & Rajagopalan, 2002).

UnificationXref672
type: UnificationXref
id: REACT_144332
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144332.5

Evidence206
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6819292
xref: PublicationXref344
xref: http://identifiers.org/pubmed/1737786
xref: http://identifiers.org/pubmed/9514741
comment: Mitochondrial ornithine aminotransferase (OAT) catalyzes the reversible reaction of ornithine and alpha-ketoglutarate to form glutamate semialdehyde and glutamate (Ohura et al. 1982). The active enzyme is a hexamer (Shen et al. 1998). Inherited OAT deficiency leads to ornithine accumulation in vivo and gyrate atrophy of the choroid and retina (Brody et al. 1992; Valle and Simell 2001).

UnificationXref673
type: UnificationXref
id: 4231378
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231378

Evidence207
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref344
xref: http://identifiers.org/pubmed/1737786
comment: Mitochondrial ornithine aminotransferase (OAT) catalyzes the reversible reaction of glutamate semialdehyde and glutamate to form ornithine and alpha-ketoglutarate (Ohura et al. 1982). The active enzyme is a hexamer (Shen et al. 1998). Inherited OAT deficiency leads to ornithine accumulation in vivo and gyrate atrophy of the choroid and retina (Brody et al. 1992; Vallee and Simell 2001).

UnificationXref674
type: UnificationXref
id: REACT_145074
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145074.5

Evidence204
type: Evidence
evidence code: inferred from electronic annotation
comment: Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases. Water-soluble vitamins include ascorbate (vitamin C) and the members of the B group: thiamin (vitamin B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). Metabolic processes annotated here include the synthesis of thiamin pyrophosphate (TPP) from thiamin (B1), the synthesis of FMN and FAD from riboflavin (B2), the synthesis of nicotinic acid (niacin - B3) from tryptophan, the synthesis of Coenzyme A from pantothenate (B5), and features of the metabolism of folate (B9).

UnificationXref675
type: UnificationXref
id: CHEBI:17407
db: ChEBI

Evidence205
type: Evidence
evidence code: inferred from electronic annotation
comment: Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases. The metabolism of water-soluble vitamins and of vitamin D are annotated in Reactome.

Taurochenodeoxycholate [ChEBI:9407]
type: SmallMoleculeReference
name: Taurochenodeoxycholate
xref: UnificationXref333

http://identifiers.org/pubmed/11208594
type: PublicationXref
id: 11208594
author: Rabelink, TJ
author: Govers, R
db: Pubmed
title: Cellular regulation of endothelial nitric oxide synthase
source: Am J Physiol Renal Physiol 280:F193-206
year: 2001

Evidence208
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19235232
comment: Serine biosynthesis starts from 3-phosphoglycerate, a glycolysis intermediate. Its dehydrogenation is catalysed by tetrameric phosphoglycerate dehydrogenase PHGDH. (Tabatabaie et al. 2009).

Evidence209
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15021249
comment: L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004).

UniProt:P65401
type: ProteinReference
xref: UnificationXref1573
organism: BioSource1

UnificationXref677
type: UnificationXref
id: REACT_161071
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161071.1

UnificationXref676
type: UnificationXref
id: 2162257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162257

UnificationXref679
type: UnificationXref
id: REACT_161537
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161537.1

UnificationXref678
type: UnificationXref
id: 2162256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162256

Evidence210
type: Evidence
evidence code: inferred from electronic annotation
comment: These reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four amino acids for glucose synthesis under fasting conditions. These reactions also provide a means to collect nitrogen, both as ammonia and as amino groups, and direct it towards urea synthesis. Transamination, the conversion of an amino acid to the corresponding alpha-keto acid coupled to the conversion of a molecule of alpha-ketoglutarate to glutamate, is the first step in the catabolism of most amino acids. Transamination reactions are freely reversible so they also provide a means to balance concentrations of various amino acids and alpha-keto (2-oxo) acids in the cytosol.

Nicotinate metabolism
type: Pathway
data source: Reactome
pathway component: REACT 89953.9
evidence: Evidence188
xref: RelationshipXref229
xref: UnificationXref1494
xref: UnificationXref1493
pathway order: PathwayStep184
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref660
type: UnificationXref
id: REACT_149618
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149618.4

UnificationXref663
type: UnificationXref
id: 428182
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428182

UnificationXref664
type: UnificationXref
id: REACT_20257
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20257.1

http://identifiers.org/pubmed/19935646
type: PublicationXref
id: 19935646
author: Jang, HG
author: Dang, L
author: Keenan, MC
author: Vander Heiden, MG
author: Bennett, BD
author: Rabinowitz, JD
author: Driggers, EM
author: Gross, S
author: Ward, PS
author: Fantin, VR
author: Thompson, CB
author: Cantley, LC
author: Marks, KM
author: White, DW
author: Bittinger, MA
author: Prins, RM
author: Su, SM
author: Yen, KE
author: Liau, LM
author: Jin, S
db: Pubmed
title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
source: Nature 462:739-44
year: 2009

UnificationXref661
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

UnificationXref662
type: UnificationXref
id: CHEBI:17862
db: ChEBI

UnificationXref668
type: UnificationXref
id: 4230856
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230856

UnificationXref667
type: UnificationXref
id: REACT_20160
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20160.2

UnificationXref666
type: UnificationXref
id: 428163
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428163

UnificationXref665
type: UnificationXref
id: CHEBI:16566
db: ChEBI

UnificationXref669
type: UnificationXref
id: 4230858
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230858

UnificationXref694
type: UnificationXref
id: CHEBI:64180
db: ChEBI

Evidence228
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18056995
xref: http://identifiers.org/pubmed/13069505
comment: AADAT dimer localized in the mitochondrial matrix catalyzes the reaction of kynurenine and 2-oxoglutarate to form 4-(2-aminophenyl)-2,4-dioxobutanoate and glutamate (Han et al. 2008). Biochemical studies of kynurenine transamination in vitro invariably measure kynurenic acid, not 4-(2-aminophenyl)-2,4-dioxobutanoate, the expected transamination product. As noted by Miller et al. (1953), "The keto acid assumed to be formed prior to ring closure in the conversion of kynurenine to kynurenic acid has not yet been detected. In principle, such detection should be possible, since it is sufficiently stable to have been synthesized. It also remains to be established whether ring closure is spontaneous, enzymatic, or both. The formation of kynurenic acid from L-kynurenine by the L-amino acid oxidase of Neurospora suggests, however, that ring closure can be spontaneous, unless the somewhat improbable assumption is made that Neurospora filtrate contained the ring-closing enzyme."

UnificationXref695
type: UnificationXref
id: 2162205
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162205

Evidence229
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1772073
comment: Tryptophan is catabolized in seven steps to yield aminomuconate. Intermedistes in this process are used as well for the synthesis of serotonin and kynurenine (Peters 1991).

UnificationXref696
type: UnificationXref
id: REACT_161345
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161345.1

Evidence226
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref371
comment: Proline is catabolized in two steps to yield L-glutamate gamma-semialdehyde, which can react further with glutamate to yield ornithine and alpha-ketoglutarate (annotated as a reaction of amino acid synthesis and interconversion) or with NAD+ to yield glutamate and NADH + H+ (Phang et al. 2001).

UnificationXref697
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Evidence227
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12140278
comment: At the beginning of this reaction, 1 molecule of '2-Amino-3-carboxymuconate semialdehyde' is present. At the end of this reaction, 1 molecule of 'CO2', and 1 molecule of '2-Aminomuconate semialdehyde' are present. This reaction takes place in the 'cytoplasm' and is mediated by the 'carboxy-lyase activity' of '2-amino-3-carboxymuconate-6-semialdehyde decarboxylase homodimer'.

UnificationXref690
type: UnificationXref
id: 4231202
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231202

Evidence224
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref366
xref: PublicationXref367
comment: The first reaction in this pathway converts phenylalanine to tyrosine, coupled to the conversion of tetrahydrobiopterin to 4a-hydroxytetrahydrobiopterin, catalyzed by phenylalanine hydroxylase. (Deficiencies in this enzyme are responsible for the commonest form of phenylketonuria (PKU) in humans.) This reaction functions both as the first step in the pathway by which the body disposes of excess phenylalanine, and as a source of the amino acid tyrosine. The next two reactions are responsible for the regeneration of tetrahydrobiopterin from 4a-hydroxytetrahydrobiopterin. The following five reactions convert tyrosine to fumarate, an intermediate in the citric acid cycle, and acetoacetate, a ketone body.

UnificationXref691
type: UnificationXref
id: 4231204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231204

Evidence225
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3944130
xref: http://identifiers.org/pubmed/9700195
xref: http://identifiers.org/pubmed/8621661
comment: Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the reaction of L-glutamate gamma-semialdehyde and NAD+ to form glutamate and NADH + H+ (Hu et al. 1996). The enzyme is a dimer (Forte-McRobbie and Pietruszko 1986). ALDH4A1 mutations cause type II hyperprolinemia in vivo (Geraghty et al. 1998).

UnificationXref692
type: UnificationXref
id: 4231206
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231206

Evidence222
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref366
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

UnificationXref693
type: UnificationXref
id: REACT_162080
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162080.2

Evidence223
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref366
comment: Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of 3-(4-hydroxyphenyl)pyruvate and glutamate to form tyrosine and alpha-keto (2-oxo) glutarate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

UnificationXref2089
type: UnificationXref
id: 4230963
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230963

UnificationXref2088
type: UnificationXref
id: 4230961
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230961

UnificationXref2087
type: UnificationXref
id: Q99TD1
db: UniProt

UnificationXref2086
type: UnificationXref
id: REACT_6438
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6438.3

UnificationXref2085
type: UnificationXref
id: 159448
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159448

UnificationXref2094
type: UnificationXref
id: 4230064
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230064

UnificationXref2095
type: UnificationXref
id: REACT_155619
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155619.3

UnificationXref2092
type: UnificationXref
id: REACT_5076
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5076.2

UnificationXref2093
type: UnificationXref
id: 4230062
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230062

UnificationXref2090
type: UnificationXref
id: REACT_159842
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159842.3

UnificationXref2091
type: UnificationXref
id: 29416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29416

Evidence232
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18323623
xref: http://identifiers.org/pubmed/19006241
xref: http://identifiers.org/pubmed/518841
comment: Cytosolic argininosuccinate synthase catalyzes the reaction of aspartate, citrulline, and ATP to form argininosuccinate, AMP, and pyrophosphate. The function of the human enzyme in vivo is inferred from the hypercitrullinemia observed in patients with defective forms of the enzyme (e.g., Engel et al. 2009). The enzyme is active as a homotetramer (OâBrien 1980; Karlberg et al. 2008).

Evidence231
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6372096
xref: http://identifiers.org/pubmed/11237854
comment: Mitochondrial ornithine transcarbamoylase (OTC) catalyzes the reaction of ornithine and carbamoyl phosphate to form citrulline (Horwich et al. 1984). The enzyme is a homotrimer (Shi et al. 2001).

Evidence230
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6249820
comment: At the beginning of this reaction, 1 molecule of 'NH4+', 1 molecule of 'HCO3-', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'Carbamoyl phosphate', 1 molecule of 'ADP', and 1 molecule of 'Orthophosphate' are present. This reaction takes place in the 'mitochondrial matrix' and is mediated by the 'carbamoyl-phosphate synthase (ammonia) activity' of 'carbamoyl-phosphate synthetase I dimer'.

UnificationXref699
type: UnificationXref
id: REACT_160998
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160998.1

UnificationXref698
type: UnificationXref
id: 2162265
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162265

http://identifiers.org/pubmed/4726295
type: PublicationXref
id: 4726295
author: Kelley, WN
author: Wyngaarden, JB
author: Holmes, EW
db: Pubmed
title: Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate
source: J Biol Chem 248:6035-6040
year: 1973

UnificationXref685
type: UnificationXref
id: Q7A5J3
db: UniProt

Evidence215
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15221005
comment: Cytosolic imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propanoate to form N-Formimino-L-glutamate. While evidence from many experimental systems indicates that this reaction occurs, existence of the human enzyme is inferred only from high-throughput screening studies (e.g., Yamada et al. 2004).

http://identifiers.org/pubmed/8571957
type: PublicationXref
id: 8571957
author: Zingg, BC
author: Mohrenweiser, HW
author: Watanabe, M
db: Pubmed
title: Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus
source: Am J Hum Genet 58:308-16
year: 1996

UnificationXref686
type: UnificationXref
id: 4231203
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231203

Evidence216
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/5057083
comment: The major pathway of histidine catabolism, annotated here, proceeds in four steps to yield glutamate and, in the process, convert one molecule of tetrahydrofolate to 5-formiminotetrahydrofolate (Morris et al. 1972). Histidine can also be decarboxylated to form histamine.

nucleoplasm
type: CellularLocationVocabulary
xref: UnificationXref157

UnificationXref683
type: UnificationXref
id: 159450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159450

Evidence217
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18056995
xref: http://identifiers.org/pubmed/18056996
xref: http://identifiers.org/pubmed/12126930
comment: Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-aminoadipate and alpha-ketoglutarate to form alpha-ketoadipate and glutamate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).

UnificationXref684
type: UnificationXref
id: REACT_7747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7747.2

Evidence218
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18056995
xref: http://identifiers.org/pubmed/18056996
xref: http://identifiers.org/pubmed/12126930
comment: Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-ketoadipate and glutamate to form alpha-aminoadipate and alpha-ketoglutarate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).

UnificationXref681
type: UnificationXref
id: 2162214
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162214

Evidence211
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11839747
xref: http://identifiers.org/pubmed/10745006
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/7918575
xref: http://identifiers.org/pubmed/15946682
xref: PublicationXref350
comment: The mitochondrial nranched-chain alpha-ketoacid dehydrogenase (BKCD) complex catalyzes the reactions of alpha-ketoisocaproate, alpha-keto beta-methylvalerate, or aalpha-ketoisovalerate with CoA and NAD+ to form isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA, respectively, and CO2 and NADH (Chuang and Shih 2001). While bovine and microbial BCKD complexes have been characterized most extensively (Reed and Hackert 1990), structural studies of individual components and subcomplexes of human BKCD have confirmed their structures and roles in the overall oxidative carboxylation process, and have related these features to the disruptive effects of mutations on branched-chain amino acid metabolism in vivo: E1a and E1b components - AEvarsson et al. 2000; E2 - Chang et al. 2002; E3- Brautigam et al. 2005. In addition, structural studies have confirmed the lipoylation of lysine residue 44 in E2 protein (Chang et al. 2002) and the loss of an aminoterminal mitochondrial transport sequence from mature E3 protein (Bruatigam et al. 2005). Loss of mitochondrial transport sequences from proteins E1a, E1b, and E2 has been domstrated by sequence analysis (Wynn et al. 1999).

http://identifiers.org/pubmed/19935667
type: PublicationXref
id: 19935667
author: Hall, RA
author: Ritter, SL
db: Pubmed
title: Fine-tuning of GPCR activity by receptor-interacting proteins
source: Nat Rev Mol Cell Biol 10:819-30
year: 2009

UnificationXref682
type: UnificationXref
id: REACT_161199
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161199.1

Evidence212
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref353
xref: PublicationXref350
comment: The branched-chain amino acids, leucine, isoleucine, and valine, are all essential amino acids (i.e., ones required in the diet). They are major constituents of muscle protein. The breakdown of these amino acids starts with two common steps catalyzed by enzymes that act on all three amino acids: reversible transamination by branched-chain amino acid aminotransferase, and irreversible oxidative decarboxylation by the branched-chain ketoacid dehydrogenase complex. Isovaleryl-CoA is produced from leucine by these two reactions, alpha-methylbutyryl-CoA from isoleucine, and isobutyryl-CoA from valine. These acyl-CoA's undergo dehydrogenation, catalyzed by three different but related enzymes, and the breakdown pathways then diverge. Leucine is ultimately converted to acetyl-CoA and acetoacetate; isoleucine to acetyl-CoA and succinyl-CoA; and valine to succinyl-CoA. Under fasting conditions, substantial amounts of all three amino acids are generated by protein breakdown. In muscle, the final products of leucine, isoleucine, and valine catabolism can be fully oxidized via the citric acid cycle; in liver they can be directed toward the synthesis of ketone bodies (acetoacetate and acetyl-CoA) and glucose (succinyl-CoA) (Chuang & Shih 2001, Sweetman & Williams 2001).

Evidence213
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15806399
comment: Cytosolic histidine ammonia lyase (HAL) catalyzes the reaction of histidine to form urocanate and NH4+ (Kawai et al. 2005).

UnificationXref680
type: UnificationXref
id: CHEBI:61011
db: ChEBI

Evidence214
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19304569
xref: http://identifiers.org/pubmed/15221005
comment: Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).

Evidence219
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/11752427
xref: http://identifiers.org/pubmed/9727038
comment: The mitochondrial alpha-ketoglutarate dehydrogenase complex catalyzes the reaction of alpha-ketoadipate, CoASH, and NAD+ to form glutaryl-CoA, CO2, and NADH. The enzyme complex contains multiple copies of three different proteins, E1 (OGDH), E2 (DLST), and E3 (DLD), each with distinct catalytic activities (Reed and Hackert 1990; Zhou et al 2001). The reaction starts with the oxidative decarboxylation of alpha-ketoadipate catalyzed by E1alpha and beta (alpha ketoglutarate dehydrogenase). Lipoamide cofactor associated with E1 is reduced at the same time. Next, the glutaryl group derived from alpha ketoglutarate is transferred to coenzyme A in two steps catalyzed E2 (dihydrolipolyl transacetylase). Finally, the oxidized form of lipoamide is regenerated and electrons are transferred to NAD+ in two steps catalyzed by E3 (dihydrolipoyl dehydrogenase). The biochemical details of this reaction have been worked out with alpha ketoglutarate dehydrogenase complex and subunits purified from bovine tissue (McCartney et al. 1998). While all of the human proteins are known as predicted protein products of cloned genes, direct experimental evidence for their functions is available only for E3 (DLD) (Brautigam et al. 2005).

UnificationXref2097
type: UnificationXref
id: REACT_155651
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155651.3

UnificationXref2096
type: UnificationXref
id: 4231277
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231277

UnificationXref2099
type: UnificationXref
id: REACT_158818
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158818.3

UnificationXref2098
type: UnificationXref
id: 4231278
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231278

http://identifiers.org/pubmed/11988738
type: PublicationXref
id: 11988738
author: Lukas, J
author: Jackson, PK
author: Reimann, JD
author: Sorensen, CS
author: Hsu, JY
db: Pubmed
title: E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
source: Nat Cell Biol 4:358-66
year: 2002

http://identifiers.org/pubmed/12626323
type: PublicationXref
id: 12626323
author: Jiang, G
author: Zhang, BB
db: Pubmed
title: Glucagon and regulation of glucose metabolism
source: Am J Physiol Endocrinol Metab 284:E671-8
year: 2003

Evidence221
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref365
xref: http://identifiers.org/pubmed/12126930
xref: PublicationXref364
xref: http://identifiers.org/pubmed/6434529
comment: In humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single enzyme complex, lysine is combined with alpha-ketoglutarate to form saccharopine, which in turn is cleaved and oxidized to yield glutamate and alpha-ketoadipic semialdehyde. The latter molecule is further oxidized to alpha-ketoadipate. Alpha-ketoadipate is oxidatively decarboxylated by the alpha-ketoglutarate dehydrogenase complex (the same enzyme complex responsible for the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle), yielding glutaryl-CoA. Glutaryl-CoA is converted to crotonyl-CoA, crotonyl-CoA is converted to beta-hydroxybutyryl-CoA, and beta-hydroxybutyryl-CoA is converted to acetoacetyl-CoA. The products of lysine catabolism are thus exclusively ketogenic; i.e., under starvation conditions they can be used for the synthesis of ketone bodies, beta-hydroxybutyrate and acetoacetate, but not for the net synthesis of glucose (Cox 2001; Goodman and Freeman 2001).

Evidence220
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15274622
xref: http://identifiers.org/pubmed/18775954
comment: Mitochondrial glutaryl-CoA dehydrogenase (GCDH) catalyzes the reaction of glutaryl-CoA and FAD to form crotonyl-CoA, FADH2, and CO2. The active enzyme is a tetramer of GCDH polypeptides lacking a 44-residue aminoterminal mitochondrial targeting sequence. Mutations in GCDH cause glutaric aciduria type 1 in vivo (Fu et al. 2004; Keyser et al. 2008).

UnificationXref689
type: UnificationXref
id: 4231201
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231201

UnificationXref688
type: UnificationXref
id: REACT_3508
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3508.3

UnificationXref687
type: UnificationXref
id: 109496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109496

3-oxohexacosanoyl-CoA [ChEBI:52977]
type: SmallMoleculeReference
name: 3-oxocerotoyl-CoA
name: 3-ketohexacosanoyl-coenzyme A
name: 3-ketocerotoyl-CoA
name: 3-ketohexacosanoyl-CoA
name: 3-oxohexacosanoyl-coenzyme A
name: 3-oxohexacosanoyl-CoA
xref: UnificationXref417

UnificationXref631
type: UnificationXref
id: CHEBI:34145
db: ChEBI

tetracosanoyl-CoA
type: SmallMoleculeReference
name: lignoceroyl-CoA
name: ChEBI:52974 tetracosanoyl-CoA
xref: UnificationXref422

UnificationXref630
type: UnificationXref
id: REACT_154872
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154872.3

UnificationXref632
type: UnificationXref
id: 2142790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142790

UnificationXref633
type: UnificationXref
id: REACT_151674
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151674.1

UnificationXref634
type: UnificationXref
id: CHEBI:34144
db: ChEBI

UnificationXref635
type: UnificationXref
id: 2142716
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142716

UnificationXref636
type: UnificationXref
id: REACT_152057
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152057.1

UnificationXref637
type: UnificationXref
id: 4231187
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231187

UnificationXref638
type: UnificationXref
id: REACT_153706
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153706.3

UnificationXref639
type: UnificationXref
id: CHEBI:15626
db: ChEBI

DNA with no 6-O-methylated guanine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3143
cellular location: intracellular
comment: Reactome DB_ID: 4230218

6-O-methyguanine containing damaged DNA
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3140
cellular location: intracellular
comment: Reactome DB_ID: 4230214

Pteroylglutamic acid
type: SmallMoleculeReference
name: Folate
name: Folic acid [ChEBI:5140]
name: Folic acid
xref: UnificationXref1495

UnificationXref620
type: UnificationXref
id: 2142707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142707

http://identifiers.org/pubmed/19006241
type: PublicationXref
id: 19006241
author: Häberle, J
author: Höhne, W
author: Engel, K
db: Pubmed
title: Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
source: Hum Mutat 30:300-7
year: 2009

UnificationXref623
type: UnificationXref
id: 4231173
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231173

UnificationXref624
type: UnificationXref
id: 4231174
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231174

UnificationXref621
type: UnificationXref
id: REACT_152496
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152496.1

UnificationXref622
type: UnificationXref
id: 4231172
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231172

UnificationXref627
type: UnificationXref
id: 4231181
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231181

UnificationXref628
type: UnificationXref
id: REACT_158052
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158052.3

UnificationXref625
type: UnificationXref
id: 4231175
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231175

UnificationXref626
type: UnificationXref
id: 4231179
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231179

UnificationXref629
type: UnificationXref
id: 4231433
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231433

DNA containing an apurinic/apyrimidinic (AP) site
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3072
cellular location: intracellular
comment: Reactome DB_ID: 4230329

Double-strand DNA containing an adenine opposite to an 8-oxo guanine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3061
cellular location: intracellular
comment: Reactome DB_ID: 4230340

Double-strand DNA containing a hypoxanthine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3057
cellular location: intracellular
comment: Reactome DB_ID: 4230352

Double-strand DNA containing an ethenoadenine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3053
cellular location: intracellular
comment: Reactome DB_ID: 4230349

Double-strand DNA containing a thymine glycol
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3109
cellular location: intracellular
comment: Reactome DB_ID: 4230319

UnificationXref651
type: UnificationXref
id: REACT_151064
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151064.1

Double-strand DNA containing a formamidopyrimidine
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3105
cellular location: intracellular
comment: Reactome DB_ID: 4230325

UnificationXref650
type: UnificationXref
id: 2142761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142761

Double-strand DNA containing a dihydrouracil
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3101
cellular location: intracellular
comment: Reactome DB_ID: 4230322

UnificationXref653
type: UnificationXref
id: 2142690
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142690

Double-strand DNA containing a cytosine glycol
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3097
cellular location: intracellular
comment: Reactome DB_ID: 4230316

UnificationXref652
type: UnificationXref
id: CHEBI:63993
db: ChEBI

cytosine glycol
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3119
cellular location: intracellular
comment: Reactome DB_ID: 4230333

Diseases associated with visual transduction
type: Pathway
data source: Reactome
pathway component: Visual phototransduction
evidence: Evidence311
xref: UnificationXref2286
xref: UnificationXref2287
pathway order: PathwayStep299
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Thymine glycol
type: PhysicalEntity
data source: Reactome
xref: UnificationXref3116
cellular location: intracellular
comment: Reactome DB_ID: 4230328

UnificationXref658
type: UnificationXref
id: REACT_156460
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_156460.3

http://identifiers.org/pubmed/16212990
type: PublicationXref
id: 16212990
author: Otis, TS
author: Dodson, PD
author: Meera, P
author: Karakossian, MH
db: Pubmed
title: Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons
source: Neuropharmacology 49:883-9
year: 2005

http://identifiers.org/pubmed/15689149
type: PublicationXref
id: 15689149
author: Fromme, JC
author: Chung, SJ
author: Verdine, GL
db: Pubmed
title: Structure of human cytidine deaminase bound to a potent inhibitor
source: J Med Chem 48:658-60
year: 2005

UnificationXref659
type: UnificationXref
id: 4231431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231431

UnificationXref654
type: UnificationXref
id: REACT_151292
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151292.1

UnificationXref655
type: UnificationXref
id: 4231183
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231183

UnificationXref656
type: UnificationXref
id: REACT_152551
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152551.3

UnificationXref657
type: UnificationXref
id: 4231434
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231434

http://identifiers.org/pubmed/11839747
type: PublicationXref
id: 11839747
author: Huang, TH
author: Chuang, JL
author: Chang, CF
author: Chuang, DT
author: Chou, HT
db: Pubmed
title: Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex
source: J Biol Chem 277:15865-73
year: 2002

UnificationXref642
type: UnificationXref
id: CHEBI:34146
db: ChEBI

UnificationXref641
type: UnificationXref
id: REACT_151618
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151618.1

UnificationXref640
type: UnificationXref
id: 2142811
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142811

UnificationXref649
type: UnificationXref
id: CHEBI:63992
db: ChEBI

UnificationXref647
type: UnificationXref
id: 4231436
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231436

UnificationXref648
type: UnificationXref
id: REACT_158726
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158726.3

UnificationXref645
type: UnificationXref
id: 4231188
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231188

UnificationXref646
type: UnificationXref
id: REACT_155698
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155698.3

UnificationXref643
type: UnificationXref
id: 2142678
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142678

UnificationXref644
type: UnificationXref
id: REACT_150517
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150517.1

Evidence166
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref289
xref: http://identifiers.org/pubmed/13211603
xref: http://identifiers.org/pubmed/12972261
xref: http://identifiers.org/pubmed/1851158
xref: http://identifiers.org/pubmed/11277919
xref: http://identifiers.org/pubmed/9488696
comment: Cytosolic nucleoside diphosphate kinases catalyze the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. These kinases are ubiquitously expressed enzymes with broad substrate specificities (Berg and Joklik 1954; Parks and Agarwal 1973). Three human cytosolic nucleoside diphosphate kinase proteins, NME1, 2, and 3, have been characterized biochemically (Gilles et al. 1991; Schaertl et al. 1998; Erent et al. 2001; Chen et al. 2003). All are catalytically active as hexamers: homohexamers of NME1, 2, and 3 have been described, as have heterohexamers containing all possible combinations of NME1 and 2 (Gilles et al. 1991; Erent et al. 2001). While cytosolic nucleoside diphosphate kinases can efficiently use several nucleotide triphosphates as a phosphate donor, the high concentrations of ATP relative to other nucleoside triphosphates in vivo makes it the likely major phosphate donor in these reactions and only reactions with ATP as the phosphate donor are annotated. All of these phosphorylation reactions are freely reversible in vitro (Parks and Agarwal 1973; Schaertl et al. 1998), but the high ratio of ATP to ADP concentrations in the cytosol should favor the conversion of (d)NDP and ATP to (d)NTP and ADP.

Evidence165
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/211390
xref: http://identifiers.org/pubmed/8663313
xref: http://identifiers.org/pubmed/177353
xref: http://identifiers.org/pubmed/6248551
comment: Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GDP and dGDP with ADP to form GMP and dGMP respectively and ATP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).

Evidence164
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/211390
xref: http://identifiers.org/pubmed/8663313
xref: http://identifiers.org/pubmed/177353
xref: http://identifiers.org/pubmed/6248551
comment: Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GMP and dGMP with ATP to form GDP and dGDP respectively and ADP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).

Evidence163
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16098809
comment: The events of human pyrimidine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of the pyrimidine ring and its conversion to uridine 5'-monophosphate (UMP), the biosynthesis of other pyrimidine ribo- and deoxyribonucleotides, pyrimidine salvage reactions, and pyrimidine catabolism (Loffler et al. 2005). De novo synthesis of the pyrimidine ring and its conversion to UMP. The pyrimidine base orotate is synthesized from glutamine, bicarbonate, and aspartate. Orotate reacts with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) and is then decarboxylated to form the pyrimidine nucleotide UMP. Pyrimidine biosynthesis [interconversion]. Pyrimidine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from UMP and from pyrimidine ribonucleotide monophosphates generated in salvage reactions. Pyrimidine salvage reactions. Pyrimidine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Pyrimidine catabolism. The pyrimidine bases thymine and uracil are degraded to beta-aminoisobutyrate and beta-alanine, respectively, which are excreted from the body.

Evidence162
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3090932
xref: http://identifiers.org/pubmed/10989446
xref: PublicationXref261
comment: In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids that can be metabolized further by reactions of branched-chain amino acid and short-chain fatty acid catabolism (Tamaki et al. 2000). The importance of these reactions in normal human pyrimidine catabolism has not been well worked out.

Evidence161
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7284378
xref: http://identifiers.org/pubmed/1590793
xref: http://identifiers.org/pubmed/14725767
comment: Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymidine or deoxyuridine with orthophosphate to form thymine or uracil and 2-deoxy-D-ribose 1-phosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Evidence160
type: Evidence
evidence code: inferred from electronic annotation
comment: 5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular CMP, TMP, or UMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Evidence158
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15689149
xref: http://identifiers.org/pubmed/7923172
comment: Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Evidence159
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref261
comment: In pyrimidine salvage reactions, nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of pyrimidine biosynthesis (interconversion).

Evidence156
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14609716
xref: http://identifiers.org/pubmed/15130468
xref: http://identifiers.org/pubmed/11306702
xref: http://identifiers.org/pubmed/195585
comment: Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).

Evidence157
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8340387
xref: http://identifiers.org/pubmed/15733844
xref: http://identifiers.org/pubmed/2026611
xref: http://identifiers.org/pubmed/3372530
xref: http://identifiers.org/pubmed/1063125
xref: http://identifiers.org/pubmed/3335503
comment: Cytosolic thymidine kinase 1 (TK1) catalyzes the reaction of thymidine and ATP to form TMP (thymidine 5'-monophosphate) and ADP. TK1 has been purified from human spleen and from cultured cells. The enzyme is active as a homotetramer, and phosphorylates thymidine and deoxyuridine using ATP as a phosphate donor in vitro (Sherley and Kelly 1988a; Munch-Petersen et al. 1991; Birringer et al. 2005). Divalent cations are required for enzyme activity (Mg++ is preferred) (Lee and Cheng 1986), and ATP stabilizes the tetrameric form of the enzyme (Munch-Petersen et al. 1993). In cells, enzyme activity is high during S phase of the cell cycle and low otherwise, correlated with intracellular levels of thymidine kinase 1 protein (Sherley and Kelly 1988b), and consistent with a requirement for TMP synthesis in normal cells only as part of DNA replication.

http://identifiers.org/pubmed/2960695
type: PublicationXref
id: 2960695
author: Danon, MJ
author: Harker, D
author: Spear, D
author: DiMauro, S
author: Vora, S
db: Pubmed
title: Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.
source: J Clin Invest 80:1479-85
year: 1987

http://identifiers.org/pubmed/7284378
type: PublicationXref
id: 7284378
author: Desgranges, C
author: Rabaud, M
author: Razaka, G
author: Bricaud, H
db: Pubmed
title: Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
source: Biochim Biophys Acta 654:211-8
year: 1981

http://identifiers.org/pubmed/9564029
type: PublicationXref
id: 9564029
author: Kushner, JP
author: Phillips, JD
author: Hill, CP
author: Whitby, FG
db: Pubmed
title: Crystal structure of human uroporphyrinogen decarboxylase
source: EMBO J 17:2463-71
year: 1998

http://identifiers.org/pubmed/20430952
type: PublicationXref
id: 20430952
author: Pugh, Edward N
author: Burns, Marie E
db: Pubmed
title: Lessons from photoreceptors: turning off G-protein signaling in living cells
source: Physiology (Bethesda) 25:72-84
year: 2010

http://identifiers.org/pubmed/18202181
type: PublicationXref
id: 18202181
author: Hub, JS
author: de Groot, BL
db: Pubmed
title: Mechanism of selectivity in aquaporins and aquaglyceroporins
source: Proc Natl Acad Sci U S A 105:1198-203
year: 2008

Evidence175
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10334869
xref: http://identifiers.org/pubmed/10329687
comment: The plasma membrane-associated transport protein SLC5A6 (SMVT) mediates the uptake of one molecule of pantothenate (PanK) and two sodium ions from the extracellular space to the cytosol. Limited Northern blotting studies suggest that SLC5A6 is widely expressed, and abundant in placenta and small intestine. SLC5A6 may thus play a central role in pantothenate uptake. SLC5A6 also mediates the uptake of biotin and lipoate (Prasad et al. 1999; Wang et al. 1999).

Evidence174
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17266529
xref: http://identifiers.org/pubmed/8283301
xref: http://identifiers.org/pubmed/20494131
comment: Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotides, the salvage and reutilization of nucleotides released by degradation of DNA and RNA, and the catabolism of excess nucleotides (Rudolph 1994). These pathways are regulated to control the total size of the intracellular nucleotide pool, to balance the relative amounts of individual nucleotides, and to couple the synthesis of deoxyribonucleotides to the onset of DNA replication (S phase of the cell cycle). These pathways are also of major clinical interest as they are the means by which nucleotide analogues used as anti-viral and anti-tumor drugs are taken up by cells, activated, and catabolized (Weilin and Nordlund 2010). As well, differences in nuclotide metabolic pathways between humans and aplicomplexan parasites like Plasmodium have been exploited to design drugs to attack the latter (Hyde 2007). The movement of nucleotides and purine and pyrimidine bases across lipid bilayer membranes, mediated by SLC transporters, is annotated as part of the module "transmembrane transport of small molecules".

Evidence177
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14523052
xref: http://identifiers.org/pubmed/11479594
xref: http://identifiers.org/pubmed/15893380
xref: http://identifiers.org/pubmed/12095677
comment: Cytosolic pantothenate kinases catalyze the reaction of ATP and pantothenate to form ADP and phosphopantothenate. This enzymatic activity has been demonstrated in crude cell extracts for two isoforms of mouse pantothenate kinase 1 (Rock et al. 2002) and for their human homologues (Ramaswamy and 2004). Two additional human genes, PANK3 and PANK4, encode closely related proteins but pantothenate kinase activity has not been demonstrated experimentally for them (Leonardi et al. 2005; Zhou et al. 2001).

Evidence176
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12554685
xref: http://identifiers.org/pubmed/17242360
xref: http://identifiers.org/pubmed/11479594
xref: http://identifiers.org/pubmed/16272150
xref: http://identifiers.org/pubmed/15105273
comment: Pantothenate kinase 2 catalyzes the reaction of ATP and pantothenate to form ADP and phosphopantothenate. While pantothenate kinase 2 co-purifies with mitocondria, its precise location within the mitochondrion has not been established (Hortnagel et al. 2003; Johnson et al. 2004). Recent work by Leonardi et al. (2007) supports a model in which the enzyme is located in the intermembrane space, hence freely accessible to small molecules from the cytosol.Pantothenate is phosphorylated by pantothenate kinase (PANK). Deficiencies in PANK2 cause a progressive neurodegenerative disorder associated with iron accumulation in the brain, but the relationship between disease symptoms and pantothenate metabolism remains unclear (Zhou et al. 2001; Zhang et al. 2006).

Evidence171
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20081199
xref: http://identifiers.org/pubmed/11278832
comment: Cytosolic ITPA dimer catalyzes the reaction of ITP and water to form IMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of ITP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).

Evidence170
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref293
xref: PublicationXref295
xref: http://identifiers.org/pubmed/5940
xref: http://identifiers.org/pubmed/11008000
xref: http://identifiers.org/pubmed/177353
comment: An array of kinases catalyze the reversible phosphorylation of nucleotide monophosphates to form nucleotide diphosphates and triphosphates. Nucleoside monophosphate kinases catalyze the reversible phosphorylation of nucleoside and deoxynucleoside 5'-monophosphates to form the corresponding nucleoside 5'-diphosphates. Most appear to have restricted specificities for nucleoside monophosphates, and to use ATP preferentially (Van Rompay et al. 2000; Anderson 1973; Noda 1973). The total number of human enzymes that catalyze these reactions in vivo is not clear. In six cases, a well-defined biochemical activity has been associated with a purified protein, and these are annotated here. However, additional nucleoside monophosphate kinase-like human proteins have been identified in molecular cloning studies whose enzymatic activities are unknown, and several distinctive nucleoside monophosphate kinase activities detected in cell extracts, e.g., a GTP-requiring adenylate kinase activity (Wilson et al. 1976) and one or more guanylate kinase activities (Jamil et al. 1975) have not been unambiguously associated with specific human proteins. The nucleoside monophosphates against which each of the six well-characterized enzymes is active is shown in the table (Van Rompay et al. 2000). All six efficiently use ATP as a phosphate donor, but have some activity with other nucleoside triphosphates as well in vitro. The high concentrations of ATP relative to other nucleoside triphosphates in vivo makes it the likely major phosphate donor in these reactions under most conditions. All of these phosphorylation reactions are freely reversible in vitro when carried out with purified enzymes and substrates, having equilibrium constants near 1. In vivo, high ratios of ATP to ADP are likely to favor the forward direction of these reactions, i.e., the conversion of (d)NMP and ATP to (d)NDP and ADP. At the same time, the reversibility of the reactions and the overlapping substrate specificities of…

Evidence173
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20081199
xref: http://identifiers.org/pubmed/11278832
comment: Cytosolic ITPA dimer catalyzes the reaction of XTP and water to form XMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of XTP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).

Evidence172
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20081199
xref: http://identifiers.org/pubmed/11278832
comment: Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).

http://identifiers.org/pubmed/17374385
type: PublicationXref
id: 17374385
author: Murgia, C
author: Devirgiliis, C
author: Perozzi, G
author: Zalewski, PD
db: Pubmed
title: Zinc fluxes and zinc transporter genes in chronic diseases
source: Mutat Res 622:84-93
year: 2007

Evidence167
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref289
xref: http://identifiers.org/pubmed/13211603
xref: http://identifiers.org/pubmed/12972261
xref: http://identifiers.org/pubmed/1851158
xref: http://identifiers.org/pubmed/11277919
xref: http://identifiers.org/pubmed/9488696
comment: Cytosolic nucleoside diphosphate kinases catalyze the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. These kinases are ubiquitously expressed enzymes with broad substrate specificities (Berg and Joklik 1954; Parks and Agarwal 1973). Three human cytosolic nucleoside diphosphate kinase proteins, NME1, 2, and 3, have been characterized biochemically (Gilles et al. 1991; Schaertl et al. 1998; Erent et al. 2001; Chen et al. 2003). All are catalytically active as hexamers: homohexamers of NME1, 2, and 3 have been described, as have heterohexamers containing all possible combinations of NME1 and 2 (Gilles et al. 1991; Erent et al. 2001). While the high ratio of ATP to ADP concentrations in the cytosol normally favors the conversion of (d)NDP and ATP to (d)NTP and ADP, the reversibility of the reactions and the overlapping substrate specificities of the enzymes suggest that this group of reverse reactions can buffer the intracellular nucleotide pool and regulate the relative concentrations of individual nucleoside di- and tri-phosphates in the pool.

Evidence168
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10799505
xref: http://identifiers.org/pubmed/18635542
xref: http://identifiers.org/pubmed/9488696
comment: Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ATP to form the corresponding nucleoside 5'-triphosphates and ADP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

Evidence169
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10799505
xref: http://identifiers.org/pubmed/18635542
xref: http://identifiers.org/pubmed/9488696
comment: Nucleoside diphosphate kinase NME4 associated with the inner mitochondrial membrane (Tokarska-Schlattner et al. 2008) catalyzes the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates with ADP to form the corresponding nucleoside 5'-diphosphates and ATP. The active form of the enzyme is a hexamer of NME4 polypeptides whose amino-terminal 33 residues, a mitochondrial translocation signal, have been removed (Milon et al. 2000). The substrate specificity of NME4 has not been examined in detail, but is inferred to be broad like that of the homologous NME1, 2, and 3 kinases (Schaertl et al. 1998).

http://identifiers.org/pubmed/8490659
type: PublicationXref
id: 8490659
author: Levinson, B
author: Whitney, S
author: Packman, S
author: Gitschier, J
author: Vulpe, C
db: Pubmed
title: Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase
source: Nat Genet 3:7-13
year: 1993

Evidence180
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11994049
xref: http://identifiers.org/pubmed/14514684
comment: The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).

http://identifiers.org/pubmed/1885595
type: PublicationXref
id: 1885595
author: Agarwal, AK
author: Tannin, GM
author: Monder, C
author: New, MI
author: White, PC
db: Pubmed
title: The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.
source: J Biol Chem 266:16653-8
year: 1991

Evidence184
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9630604
xref: http://identifiers.org/pubmed/20153287
xref: http://identifiers.org/pubmed/22123817
comment: Once biotinylated, three halocarboxylases (hCBXs) are localised to the mitochondrial matrix. The mechanism of transfer is still unclear. Pyruvate carboxylase (PC) is required for gluconeogenesis, lipogenesis, neurotransmitter synthesis and insulin secretion; Methylcrotonyl-CoA carboxylase (MCC) is required for amino acid metabolism; propionyl-CoA carboxylase (PCC) is required for odd-chain fatty acid oxidation (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010).

Evidence183
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10334869
xref: http://identifiers.org/pubmed/10329687
xref: http://identifiers.org/pubmed/12646417
comment: The plasma membrane-associated transport protein SLC5A6 (aka sodium-dependent multivitamin transporter, SMVT) mediates the uptake of one molecule of biotin (Btn) and two sodium ions from the extracellular space to the cytosol. Limited Northern blotting studies suggest that SLC5A6 is widely expressed and abundant in placenta, liver and small intestine. SLC5A6 may thus play a central role in Btn uptake from dietary sources. SLC5A6 also mediates the uptake of pantothenate and lipoate (Prasad et al. 1999; Wang et al. 1999, Balamurugan et al. 2003).

Evidence182
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12815048
xref: http://identifiers.org/pubmed/2981478
comment: Panthothenate (vitamin B5) is the precursor of coenzyme A (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every foodstuff.

Evidence181
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11158296
xref: http://identifiers.org/pubmed/15893380
xref: http://identifiers.org/pubmed/13032008
xref: http://identifiers.org/pubmed/11923312
xref: http://identifiers.org/pubmed/2981478
comment: Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).

Evidence188
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14704851
comment: Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan.

Evidence187
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14704851
comment: Nicotinamide levels are modulated by the action of three enzymes involved in nicotinamide salvaging. They are nicotinamide deaminase, nicotinamide phosphoribosyltransferase and nicotinate phosphoribosyltransferase. These enzymes are poorly characterized in humans, depsite their importance in nicotinamide utilization.

Evidence186
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4349867
xref: http://identifiers.org/pubmed/13563527
xref: http://identifiers.org/pubmed/17604275
comment: Cytosolic nicotinate phosphoribosyltransferase (NaPRT) catalyzes the Mg++-dependent reaction of nicotinate and phosphoribosyl pyrophosphate to form nicotinate mononucleotide (NaMN, nicotinate D-ribonucleotide) and pyrophosphate. The active form of the enzyme is a homodimer (Preiss and Handler 1958; Niedel and Dietrich 1973; Hara et al. 2007).

Evidence185
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19319844
comment: Biotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the intestinal lumen by the SLC5A6 transporter. Its uptake, intracellular translocation, covalent conjugation to apoenzymes, and salvage are described here.

GFPT1/2
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 2
xref: UnificationXref2971
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230958

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64228
data source: Reactome
name: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 1
name: P64228
xref: UnificationXref2969
feature: FragmentFeature252
cellular location: intracellular
comment: Reactome DB_ID: 4230956
display name: GFPT1

Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 2
type: Protein
entity reference: P64228
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: GFPT2(2-682)
name: P64228
xref: UnificationXref2970
feature: FragmentFeature253
cellular location: intracellular
comment: Reactome DB_ID: 4230957
display name: GFPT2

Evidence178
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15581364
xref: http://identifiers.org/pubmed/11923312
comment: The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit. While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.

Evidence179
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11994049
xref: http://identifiers.org/pubmed/14514684
comment: The adenylyl transferase activity of bifunctional coenzyme A synthase (COASY) catalyzes the transfer of an adenylyl group from ATP to pantetheinephosphate (PPANT) to form dephospho-Coenzyme A (DP-CoA) (Daugherty et al. 2002). The enzyme is associated with the mitochondrial outer membrane (Zhyvoloup et al. 2003).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3E6
data source: Reactome
name: Copper-transporting ATPase 1
name: ATP7A_HUMAN
name: Q7A3E6
xref: UnificationXref2923
feature: FragmentFeature246
cellular location: plasma membrane
comment: Reactome DB_ID: 4231033
display name: ATP7A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3E6
data source: Reactome
name: Copper-transporting ATPase 2
name: ATP7B_HUMAN
name: Q7A3E6
xref: UnificationXref2928
feature: FragmentFeature247
cellular location: intracellular
comment: Reactome DB_ID: 4231036
display name: ATP7B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: SLC17A3
name: SLC17A3 isoform 1
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3-1
xref: UnificationXref2938
feature: FragmentFeature248
cellular location: intracellular
comment: Reactome DB_ID: 4231238
display name: Q7A3I9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: SLC17A3 isoform 2
name: NPT4_HUMAN
name: Sodium-dependent phosphate transport protein 4
name: SLC17A3(1-498)
name: SLC17A3-2
xref: UnificationXref2946
feature: FragmentFeature249
cellular location: plasma membrane
comment: Reactome DB_ID: 4231235
display name: Q7A3I9

Homologues of SLC9C1
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2956
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231232

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: SL9C1_HUMAN
name: Sodium/hydrogen exchanger 10
name: Q7A3Q7
xref: UnificationXref2954
feature: FragmentFeature250
cellular location: intracellular
comment: Reactome DB_ID: 4231230
display name: SLC9C1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Q7A721
name: SL9C1_HUMAN
name: Sodium/hydrogen exchanger 10
xref: UnificationXref2955
feature: FragmentFeature251
cellular location: intracellular
comment: Reactome DB_ID: 4231231
display name: SLC9C1

http://identifiers.org/pubmed/8687421
type: PublicationXref
id: 8687421
author: Ishihara, H
author: Matsutani, A
author: Takeuchi, Y
author: Oka, Y
author: Kuwano, S
db: Pubmed
title: Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene
source: Biochem Biophys Res Commun 223:481-6
year: 1996

Evidence191
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Cytosolic folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of THF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal THF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

Evidence190
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2248959
xref: http://identifiers.org/pubmed/6323448
comment: Cytosolic dihydrofolate reductase catalyzes the reaction of dihydrofolate, NADPH, and H+ to form tetrahydrofolate (THF) and NADP+ (Chen et al. 1984; Davies et al. 1990).

Evidence193
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Mitochondrial folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest mitochondrial form of THF has six added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the mitochondrial matrix so this reaction is needed for normal THF function under physiological conditions. The mitochondrial and cytosolic forms of folylpolyglutamate synthase are encoded by the same gene - alternative splicing generates mRNA with or without an initial exon encoding a mitochondrial targeting sequence (Garrow et al. 1992; Chen et al. 1996).

Evidence192
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8662720
xref: http://identifiers.org/pubmed/1409616
comment: Cytosolic folylpolyglutamate synthase catalyzes the reaction of 5-methylTHF-glutamate(n), L-glutamate, and ATP to form 5-methylTHF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of 5-methylTHF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of 5-methylTHF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, 5-methylTHF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal 5-methylTHF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

Lysine catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction139
pathway component: BiochemicalReaction138
pathway component: BiochemicalReaction140
pathway component: BiochemicalReaction137
evidence: Evidence221
xref: RelationshipXref270
xref: UnificationXref1728
xref: UnificationXref1729
pathway order: PathwayStep217
pathway order: PathwayStep215
pathway order: PathwayStep216
pathway order: PathwayStep214
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence195
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence194
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The formate-tetrahydrofolate ligase activity of the trifunctional MTHFD1 enzyme catalyzes the reaction of THF polyglutamate, formate, and ATP to form 10-formylTHF polyglutamate, ADP, and orthophosphate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

http://identifiers.org/pubmed/8490646
type: PublicationXref
id: 8490646
author: Petterson, A
author: Monaco, AP
author: Chelly, J
author: Ishikawa-Brush, Y
author: Horn, N
author: Tønnesen, T
author: Tommerup, N
author: Tümer, Z
db: Pubmed
title: Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein
source: Nat Genet 3:14-9
year: 1993

http://identifiers.org/pubmed/10529898
type: PublicationXref
id: 10529898
author: Wahli, W
author: Desvergne, B
db: Pubmed
title: Peroxisome proliferator-activated receptors: nuclear control of metabolism
source: Endocr Rev 20:649-88
year: 1999

Evidence197
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and NADP+ to form 5,10-methenylTHF polyglutamate, NADPH, and H+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Evidence196
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate, NADPH, and H+ to form 5,10-methyleneTHF polyglutamate and NADP+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

(R)-2-hydroxyglutaric acid
type: SmallMoleculeReference
name: (R)-2-Hydroxyglutarate
name: ChEBI:32796 (R)-2-hydroxyglutaric acid
xref: UnificationXref862

Evidence199
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11001804
xref: http://identifiers.org/pubmed/10466189
comment: Folates are essential cofactors that provide one-carbon moieties in various states of reduction for biosynthetic reactions. Processes annotated here include transport reactions by which folates are taken up by cells and moved intracellularly, folate conjugation with glutamate (required for folate retention within a cell), and some of the key reactions in the generation of reduced folates and one-carbon derivatives of folate.

Evidence198
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3053686
xref: http://identifiers.org/pubmed/3871768
comment: The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate and H2O to form 10-formylTHF polyglutamate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5V8
data source: Reactome
name: Aquaporin-9
name: AQP9_HUMAN
name: Q7A5V8
xref: UnificationXref2883
feature: FragmentFeature244
cellular location: plasma membrane
comment: Reactome DB_ID: 4230879
display name: AQP9

Evidence189
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2248959
xref: http://identifiers.org/pubmed/6323448
comment: Cytosolic dihydrofolate reductase catalyzes the reaction of folate, NADPH, and H+ to form dihydrofolate and NADP+ (Chen et al. 1984; Davies et al. 1990).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5V8
data source: Reactome
name: Aquaporin-10
name: AQP10_HUMAN
name: Q7A5V8
xref: UnificationXref2885
feature: FragmentFeature245
cellular location: plasma membrane
comment: Reactome DB_ID: 4230993
display name: AQP10

http://identifiers.org/pubmed/3208766
type: PublicationXref
id: 3208766
author: Day, IN
author: Fothergill, JE
author: McAleese, SM
author: Hinks, LJ
author: Dunbar, B
db: Pubmed
title: Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
source: Eur J Biochem 178:413-7
year: 1988

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5V8
data source: Reactome
name: Aquaporin-3
name: AQP3_HUMAN
name: Q7A5V8
xref: UnificationXref2879
feature: FragmentFeature242
cellular location: plasma membrane
comment: Reactome DB_ID: 4230943
display name: AQP3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5V8
data source: Reactome
name: AQP7_HUMAN
name: Aquaporin-7
name: Q7A5V8
xref: UnificationXref2881
feature: FragmentFeature243
cellular location: plasma membrane
comment: Reactome DB_ID: 4230883
display name: AQP7

http://identifiers.org/pubmed/20301677
type: PublicationXref
id: 20301677
author: Mitchell, JJ
author: Scriver, CR
db: Pubmed
title: Phenylalanine Hydroxylase Deficiency
year: 2010

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A706
data source: Reactome
name: sodium-coupled nucleoside transporter, member 3
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
name: SLC28A3
xref: UnificationXref2857
feature: FragmentFeature237
cellular location: plasma membrane
comment: Reactome DB_ID: 4230290
display name: Q7A706

http://identifiers.org/pubmed/7859077
type: PublicationXref
id: 7859077
author: Plaitakis, A
author: Shashidharan, P
author: Morrison, JH
author: Huntley, GW
author: Meyer, T
db: Pubmed
title: Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain
source: Brain Res 662:245-50
year: 1994

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7A0
data source: Reactome
name: sodium-coupled nucleoside transporter, member 3
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
name: SLC28A3
xref: UnificationXref2858
feature: FragmentFeature238
cellular location: plasma membrane
comment: Reactome DB_ID: 4230291
display name: Q7A7A0

CNT 2
type: Protein
entity reference: Q7A706
data source: Reactome
name: SPNT
name: Sodium/purine nucleoside co- transporter
name: Na(+)/nucleoside cotransporter 2
name: Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT)
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 2
name: Q7A706
name: Sodium/nucleoside cotransporter 2
name: SLC28A2
name: Concentrative nucleoside transporter 2
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
name: hCNT2
xref: UnificationXref2867
feature: FragmentFeature240
cellular location: plasma membrane
comment: Reactome DB_ID: 4230296
display name: CNT2

Acetylation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction178
pathway component: BiochemicalReaction177
pathway component: BiochemicalReaction176
evidence: Evidence282
xref: UnificationXref2166
xref: UnificationXref2167
pathway order: PathwayStep275
pathway order: PathwayStep277
pathway order: PathwayStep276
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

CNT 2
type: Protein
entity reference: Q7A7A0
data source: Reactome
name: Q7A7A0
name: SPNT
name: Sodium/purine nucleoside co- transporter
name: Na(+)/nucleoside cotransporter 2
name: Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT)
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 2
name: Sodium/nucleoside cotransporter 2
name: SLC28A2
name: Concentrative nucleoside transporter 2
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
name: hCNT2
xref: UnificationXref2868
feature: FragmentFeature241
cellular location: plasma membrane
comment: Reactome DB_ID: 4230297
display name: CNT2

Homologues of SLC28A2
type: Protein
data source: Reactome
member physical entity: CNT 2
xref: UnificationXref2869
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230298

CNT 2
type: Protein
entity reference: Q7A7P7
data source: Reactome
name: SPNT
name: Sodium/purine nucleoside co- transporter
name: Na(+)/nucleoside cotransporter 2
name: Q7A7P7
name: Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT)
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 2
name: Sodium/nucleoside cotransporter 2
name: SLC28A2
name: Concentrative nucleoside transporter 2
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
name: hCNT2
xref: UnificationXref2866
feature: FragmentFeature239
cellular location: plasma membrane
comment: Reactome DB_ID: 4230295
display name: CNT2

Evidence121
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4348202
xref: http://identifiers.org/pubmed/4726295
comment: PRPP stimulates the dissociation of phosphoribosyl pyrophosphate amidotransferase tetramers to form dimers (Holmes et al. 1973a,b).

Evidence122
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/762062
xref: http://identifiers.org/pubmed/4348202
xref: http://identifiers.org/pubmed/4726295
xref: http://identifiers.org/pubmed/8380692
xref: http://identifiers.org/pubmed/18388293
comment: Cytosolic PPAT (phosphoribosyl pyrophosphate amidotransferase) catalyzes the reaction of 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), water, and L-glutamine to form 5-phosphoribosylamine, L-glutamate, and pyrophosphate. This event is the committed step in de novo purine synthesis. The reaction itself is reversible, but it is pulled strongly in the direction of 5'-phosphoribosylamine synthesis by the irreversible hydrolysis of the pyrophosphate that is also formed in the reaction. Fluoresence microscopy studies of cultured human cells have shown that PPAT is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008). The PPAT enzyme is inferred to be an iron-sulfur protein, like its well-characterized B. subtilis homologue, because incubation of purified enzyme with molecular oxygen or chelating agents inactivates it, and activity can be restored by incubation with ferrous iron and inorganic sulfide. The stoichiometry of the iron-sulfur moiety and its role in enzyme activity remain unknown (Itakura and Holmes 1979). The fully active form of the enzyme is a dimer, which can associate further to form a tetramer with sharply reduced activity (Holmes et al. 1973b; Iwahana et al. 1993). Interaction of the enzyme with inosine 5'-monophosphate (IMP), guanosine 5'-monophosphate (GMP), and adenosine 5'-monophosphate (AMP), end products of de novo purine biosynthesis, favors tetramer formation, while interaction with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), a required substrate, favors formation of the active dimer. Kinetic studies suggest that the enzyme's binding site for GMP and IMP is separate from its AMP binding site (Holmes et al. 1973a).

Evidence120
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4348202
xref: http://identifiers.org/pubmed/4726295
comment: Cytosolic AMP, GMP, and IMP stimulate the association of phosphoribosyl pyrophosphate amidotransferase (PPAT) dimers to form tetramers (Holmes et al. 1973a,b).

UnificationXref588
type: UnificationXref
id: REACT_154984
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154984.3

UnificationXref589
type: UnificationXref
id: CHEBI:15632
db: ChEBI

http://identifiers.org/pubmed/9083101
type: PublicationXref
id: 9083101
author: Hosaka, K
author: Nikawa, J
author: Nakashima, A
db: Pubmed
title: Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
source: J Biol Chem 272:9567-72
year: 1997

Metabolism of water-soluble vitamins and cofactors
type: Pathway
data source: Reactome
pathway component: REACT 135682.5
pathway component: Metabolism of folate and pterines
pathway component: REACT 102636.9
pathway component: Nicotinate metabolism
pathway component: REACT 98061.9
evidence: Evidence204
xref: RelationshipXref248
xref: UnificationXref1600
xref: UnificationXref1599
pathway order: PathwayStep179
pathway order: PathwayStep196
pathway order: PathwayStep200
pathway order: PathwayStep182
pathway order: PathwayStep185
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence119
type: Evidence
evidence code: inferred from electronic annotation
comment: The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to drive ATP synthesis.

UnificationXref585
type: UnificationXref
id: 4231164
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231164

Evidence118
type: Evidence
evidence code: inferred from electronic annotation
comment: Pyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the reversible oxidation of lactate or transamination of alanine, can be converted to acetyl CoA. Other sources of acetyl CoA include breakdown of free fatty acids and ketone bodies in the fasting state. Acetyl CoA can enter the citric acid cycle, a major source of reducing equivalents used to synthesize ATP, or enter biosynthetic pathways. In addition to its role in energy generation, the citric acid cycle is a source of carbon skeletons for amino acid metabolism and other biosynthetic processes. One such process included here is the interconversion of 2-hydroxyglutarate, probably derived from porphyrin and amino acid metabolism, and 2-oxoglutarate (alpha-ketoglutarate), a citric acid cycle intermediate.

UnificationXref584
type: UnificationXref
id: REACT_150859
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150859.1

Evidence117
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16601864
xref: http://identifiers.org/pubmed/19935646
xref: http://identifiers.org/pubmed/18772396
comment: The two stereoisomers of 2-hydroxyglutarate are normally converted to 2-oxoglutarate in the mitochondrial matrix, and can then be metabolized by the citric acid cycle. The physiological sources of 2-hydroxyglutarate have not been established although plausible hypotheses are that it is generated by lysine breakdown or as a byproduct of delta-aminolevulinate metabolism. The stereoisomers are oxidized to 2-oxoglutarate in FAD-dependent reactions catalyzed by the enzymes D2HGDH (specific for R(-)-2-hydroxyglutarate) and L2HGDH (specific for S(-)-2-hydroxyglutarate). An inherited deficiency in either enzyme is associated with accumulation of 2-hydroxyglutarate and variable neurological symptoms. R(-)-2-hydroxyglutarate also reacts reversibly with succinate semialdehyde to form 4-hydroxybutyrate and 2-oxoglutarate, catalyzed by ADHFE1. No deficiencies of this enzyme have been found in patients with elevated 2-hydroxyglutarate levels (Struys 2006).

UnificationXref587
type: UnificationXref
id: 4231430
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231430

Evidence116
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16435184
xref: http://identifiers.org/pubmed/3182820
comment: ADHFE1 catalyzes the reversible reaction of 2-oxoglutarate and 4-hydroxybutyrate to form (R)-2-hydroxyglutarate and succinate semialdehyde (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988).

UnificationXref586
type: UnificationXref
id: REACT_153121
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153121.3

Evidence115
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16435184
xref: http://identifiers.org/pubmed/3182820
comment: ADHFE1 catalyzes the reversible reaction of (R)-2-hydroxyglutarate and succinate semialdehyde to form 2-oxoglutarate and 4-hydroxybutyrate (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988).

UnificationXref581
type: UnificationXref
id: REACT_17747
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17747.2

Evidence114
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16746585
xref: http://identifiers.org/pubmed/16747180
xref: http://identifiers.org/pubmed/6773467
comment: In the citric acid or tricarboxylic acid (TCA) cycle, the acetyl group of acetyl CoA (derived primarily from oxidative decarboxylation of pyruvate, beta-oxidation of long-chain fatty acids, and catabolism of ketone bodies and several amino acids) can be completely oxidized to CO2 in reactions that also yield one high-energy phosphate bond (as GTP or ATP) and four reducing equivalents (three NADH + H+, and one FADH2). The NADH and FADH2 are then oxidized by the electron transport chain to yield nine more high-energy phosphate bonds (as ATP). All reactions of the citric acid cycle take place in the mitochondrion. Eight canonical reactions mediate the synthesis of citrate from acetyl-CoA and oxaloacetate and the metabolism of citrate to re-form oxaloacetate. Six additional reactions are included here. Three reversible reactions, the interconversions of citrate and isocitrate, of fumarate and malate, and of malate and oxaloacetate are annotated in both their canonical (forward) and reverse directions. The synthesis of succinate from succinyl-CoA can be coupled to the phosphorylation of either GDP (the canonical reaction) or ADP; both reactions are annotated. Two mitochondrial isocitrate dehydrogenase isozymes catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (2-oxoglutarate): IDH3 catalyzes the canonical reaction coupled to the reduction of NAD+, while IDH2 catalyzes the same reaction coupled to reduction of NADP+, a reaction whose normal physiological function is unclear. Both reactions are annotated. Finally, a reaction is annotated in which reducing equivalents are transferred from NADPH to NAD+ coupled to proton import across the inner mitochondrial membrane. The cyclical nature of the reactions responsible for the oxidation of acetate was first suggested by Hans Krebs, from biochemical studies of pigeon breast muscle (Krebs et al. 1938; Krebs and Eggleston 1940). Many of the molecular details of individual reactions were worked out by…

UnificationXref580
type: UnificationXref
id: 266056
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266056

Evidence113
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8200987
comment: Mitochondrial fumarate hydratase catalyzes the reversible reaction of malate to form fumarate and water (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

UnificationXref583
type: UnificationXref
id: 2142810
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142810

Evidence112
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8200987
comment: Mitochondrial fumarate hydratase catalyzes the reversible reaction of fumarate and water to form malate, the seventh step of the TCA cycle (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

UnificationXref582
type: UnificationXref
id: CHEBI:27814
db: ChEBI

Evidence130
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8567683
xref: http://identifiers.org/pubmed/11096114
xref: http://identifiers.org/pubmed/18388293
comment: The reversible synthesis of inosine 5'-monophosphate from 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) is catalyzed by the IMP cyclohydrolase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

eNOS activation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction52
pathway component: BiochemicalReaction50
pathway component: BiochemicalReaction51
evidence: Evidence101
xref: RelationshipXref112
xref: UnificationXref751
xref: UnificationXref750
pathway order: PathwayStep96
pathway order: PathwayStep97
pathway order: PathwayStep95
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence131
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7903306
comment: Two human isoenzymes, IMP dehydrogenase 1 and 2 (IMPDH1,2) catalyze the irreversible dehydrogenation of inosine 5'-monophosphate (IMP) to form xanthosine 5'-monophosphate (XMP). The active forms of both isoenzymes are homotetramers, and they are nearly identical in their catalytic efficiencies and their susceptibility to inhibition by XMP (Carr et al. 1993; Colby et al. 1999; Hager et al. 1995). Both enzymes occur as homotetramers (Colby et al. 1999 - IMPDH2; unpubliched data in PDB 1JCN IMPDH1). A variety of experiments suggest that IMPDH1 and 2 have distinct functions in vivo. While IMPDH1 is expressed at constant levels, IMPDH2 is expressed at elevated levels in tumor cells and in mitotic normal cells. In humans, heterozygosity for mutant forms of IMPDH1 is associated with a form of retinitis pigmentosa (Bowne et al. 2002). In laboratory mice, mutations that disrupt the homologue of IMPDH1 have no obvious effect at the level of the whole organism, while ones that disrupt IMPDH2 are lethal (Gu et al. 2003). This reaction is the rate limiting step in the synthesis of guanosine 5'-monophosphate (GMP) from IMP, and GMP competitively inhibits the well-characterized bacterial IMP dehydrogenase enzyme. Evidence for an inhibitory effect of GMP on the human isoenzymes has not been reported. Rather, they appear to be inhibited by XMP; in addition, transcription of one or both IMP dehydrogenase mRNAs may be inhibited by high cellular GMP concentrations (Glesne et al. 1991).

Evidence132
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8089153
xref: http://identifiers.org/pubmed/7706277
comment: Cytosolic GMP synthase (GMPS) catalyzes the reaction of xanthosine 5'-monophosphate (XMP), ATP, glutamine and water to form guanosine 5'-monophosphate (GMP), AMP, glutamate and pyrophosphate. GMPS is a monomer (Hirst et al. 1994; Nakamura and Lou 1995).

Evidence133
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15786719
xref: http://identifiers.org/pubmed/1592113
comment: Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.

UnificationXref599
type: UnificationXref
id: 2142733
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142733

Carnitine synthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction152
evidence: Evidence238
xref: UnificationXref1846
xref: UnificationXref1845
xref: RelationshipXref296
pathway order: PathwayStep234
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref590
type: UnificationXref
id: 266010
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266010

http://identifiers.org/pubmed/11891227
type: PublicationXref
id: 11891227
author: Mendel, RR
author: Schwarz, G
author: Hänzelmann, P
db: Pubmed
title: Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis
source: J Biol Chem 277:18303-12
year: 2002

Organic anion transporters
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction225
pathway component: BiochemicalReaction228
pathway component: BiochemicalReaction224
pathway component: BiochemicalReaction223
pathway component: BiochemicalReaction227
pathway component: BiochemicalReaction226
evidence: Evidence370
xref: UnificationXref2720
xref: UnificationXref2721
pathway order: PathwayStep359
pathway order: PathwayStep355
pathway order: PathwayStep356
pathway order: PathwayStep360
pathway order: PathwayStep357
pathway order: PathwayStep358
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19530173
type: PublicationXref
id: 19530173
author: Oishi, Isao
author: Endo, Mitsuharu
author: Minami, Yasuhiro
author: Nishita, Michiru
db: Pubmed
title: Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases
source: Dev. Dyn. 239:1-15
year: 2010

http://identifiers.org/pubmed/12690580
type: PublicationXref
id: 12690580
author: Jordanova, A
author: Lee-Lin, SQ
author: Funalot, B
author: Antonellis, A
author: Sivakumar, K
author: Kremensky, I
author: Ellsworth, RE
author: Middleton, LT
author: Sambuughin, N
author: Goldfarb, LG
author: Christodoulou, K
author: Fischbeck, KH
author: Green, ED
author: Ionasescu, V
author: Abel, A
author: Vance, JM
author: Puls, I
db: Pubmed
title: Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V
source: Am J Hum Genet 72:1293-9
year: 2003

Evidence128
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10958654
xref: http://identifiers.org/pubmed/8366112
xref: http://identifiers.org/pubmed/18388293
comment: The reversible conversion of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate is catalyzed by adenylosuccinate lyase. The active form of this enzyme is a cytosolic tetramer (Stone et al. 1993), and fluoresence microscopy of cultured human cells suggests that it may associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008). The enzyme also catalyzes the conversion of adenylosuccinate to adenosine 5'-monophosphate and fumarate. Humans lacking the enzyme accumulate dephosphorylated forms of both substrates, indicating that the enzyme mediates both reactions in vivo as well (Race et al. 2000).

UnificationXref598
type: UnificationXref
id: CHEBI:28209
db: ChEBI

Evidence127
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2183217
xref: http://identifiers.org/pubmed/17224163
xref: http://identifiers.org/pubmed/18388293
comment: The conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) and aspartate to 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole succinocarboxamide synthetase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

UnificationXref597
type: UnificationXref
id: REACT_3495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3495.2

UnificationXref596
type: UnificationXref
id: 111745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745

http://identifiers.org/pubmed/9722522
type: PublicationXref
id: 9722522
author: Saks, VA
author: Boero, J
author: Qin, W
author: Khuchua, ZA
author: Strauss, AW
author: Payne, RM
author: Cheng, J
db: Pubmed
title: Octamer formation and coupling of cardiac sarcomeric mitochondrial creatine kinase are mediated by charged N-terminal residues
source: J Biol Chem 273:22990-6
year: 1998

Evidence129
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8567683
xref: http://identifiers.org/pubmed/11096114
xref: http://identifiers.org/pubmed/18388293
comment: The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

UnificationXref595
type: UnificationXref
id: CHEBI:17858
db: ChEBI

Evidence124
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2147474
xref: http://identifiers.org/pubmed/11381136
xref: http://identifiers.org/pubmed/18388293
xref: http://identifiers.org/pubmed/12450384
comment: The irreversible transfer of a formyl group to cytosolic 5-phosphoribosylglycinamide (GAR) to form 5'-phosphoribosylformylglycinamide (FGAR) is catalyzed by the phosphoribosylglycinamide formyltransferase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990; Zhang et al. 2002). Fluoresence microscopy studies of cultured human cells have shown that GART is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

UnificationXref594
type: UnificationXref
id: REACT_3050
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3050.2

Evidence123
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2147474
xref: http://identifiers.org/pubmed/11381136
xref: http://identifiers.org/pubmed/18388293
comment: The synthesis of cytosolic 5-phosphoribosylglycinamide from 5-phosphoribosylamine and glycine, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylglycinamide synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic (Gooljarsingh et al. 2001; An et al. 2008).

UnificationXref593
type: UnificationXref
id: 29450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450

http://identifiers.org/pubmed/15863030
type: PublicationXref
id: 15863030
author: Schlessinger, J
author: Eswarakumar, VP
author: Lax, I
db: Pubmed
title: Cellular signaling by fibroblast growth factor receptors
source: Cytokine Growth Factor Rev 16:139-49
year: 2005

Evidence126
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2183217
xref: http://identifiers.org/pubmed/17224163
xref: http://identifiers.org/pubmed/18388293
comment: The reversible carboxylation of 5'-phosphoribosyl-5-aminoimidazole (AIR) to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) is catalyzed by the phosphoribosylaminoimidazole carboxylase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

UnificationXref592
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Evidence125
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2147474
xref: http://identifiers.org/pubmed/11381136
xref: http://identifiers.org/pubmed/18388293
comment: The irreversible synthesis of cytosolic 5'-phosphoribosyl-5-aminoimidazole (AIR) from 5'-phosphoribosylformylglycinamidine (FGAM), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic and may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

UnificationXref591
type: UnificationXref
id: REACT_15596
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15596.2

Evidence140
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3036115
xref: http://identifiers.org/pubmed/1637327
xref: http://identifiers.org/pubmed/2129526
comment: 5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular AMP, dAMP, GMP, or IMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Evidence143
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4620886
comment: The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.

Evidence144
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4620886
comment: The events of human purine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of inosine 5'-monophosphate (IMP), the biosynthesis of other purine ribo- and deoxyribonucleotides, purine salvage reactions, and purine catabolism (Watts 1974). De novo synthesis of inosine 5'-monophosphate (IMP). The purine ribonucleotide IMP is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP). Purine biosynthesis [interconversion]. Purine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from IMP and from guanosine and adenosine ribo- and deoxyribonucleotide monophosphates generated in salvage reactions. Purine salvage reactions. Purine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Purine catabolism. The purine bases guanine and hypoxanthine are degraded to uric acid, which is excreted from the body.

Evidence141
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/807573
xref: http://identifiers.org/pubmed/3457020
xref: http://identifiers.org/pubmed/20070187
xref: http://identifiers.org/pubmed/8428933
comment: Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).

Evidence142
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1999334
xref: http://identifiers.org/pubmed/10656833
comment: Hydrogen peroxide is generated in the course of peroxisomal fatty acid oxidation and purine catabolism, and is rapidly converted to water and molecular oxygen by the enzyme catalase. This enzyme is widely distributed in the body, but is especially abundant in liver, kidney, and red blood cells.

http://identifiers.org/pubmed/20810651
type: PublicationXref
id: 20810651
author: Kitamura, Kenichiro
author: Anzai, N
author: Yamanaka, Hisashi
author: Urano, Wako
author: Sakurai, Hiroyuki
author: Taniguchi, Atsuo
author: Jutabha, P
author: Fujita, T
author: Endou, H
author: Katada, Tomohisa
author: Kimura, Toru
author: Moriyama, Yoshinori
author: Seki, George
author: Yamada, Hideomi
author: Wempe, Michael F
author: Yamada, Akira
author: Tomita, Kimio
author: Kaneko, Shuji
author: Uchida, Shunya
author: Yan, Kunimasa
author: Shimada, Hidetaka
author: Fukutomi, Toshiyuki
db: Pubmed
title: Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate
source: J. Biol. Chem. 285:35123-32
year: 2010

http://identifiers.org/pubmed/10958654
type: PublicationXref
id: 10958654
author: Vincent, MF
author: Marie, S
author: Van den Berghe, G
author: Race, V
db: Pubmed
title: Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
source: Hum Mol Genet 9:2159-2165
year: 2000

Evidence137
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/457664
comment: Cytosolic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979).

Evidence136
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9857047
xref: http://identifiers.org/pubmed/1429593
comment: Cytosolic AMP deaminase (AMPD) catalyzes the hydrolysis of AMP to yield IMP and ammonia. Three isoforms of AMPD, E, L, and M, have been identified that differ in their expression patterns in the body. All occur as tetramers and all have qualitatively the same catalytic activity, however (Bausch-Jurken et al. 1992; Mahnke-Zizelman et al. 1998).

Evidence135
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1574589
comment: The purine ribonucleotide inosine 5'-monophosphate (IMP) is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), with atoms derived from aspartate, glutamine, glycine, N10-formyl-tetrahydrofolate, and carbon dioxide. Although several of the individual reactions in this sequence are reversible, as indicated by the double-headed arrows in the diagram, other irreversible steps drive the pathway in the direction of IMP synthesis in the normal cell. All of these reactions are thus annotated here only in the direction of IMP synthesis. Guanosine 5'-monophosphate (GMP) and adenosine 5'-monophosphate (AMP) are synthesized from IMP.

Evidence134
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10958654
xref: http://identifiers.org/pubmed/8366112
comment: The irreversible conversion of adenylosuccinate to adenosine 5'-monophosphate and fumarate is catalyzed by adenylosuccinate lyase. The active form of this enzyme is a cytosolic tetramer (Stone et al. 1993). The enzyme also catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate. Humans lacking the enzyme accumulate dephosphorylated forms of both substrates, indicating that the enzyme mediates both reactions in vivo as well (Race et al. 2000).

Evidence139
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4620886
comment: Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by DNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of purine biosynthesis. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974).

Evidence138
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6300847
comment: Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Evidence150
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8631878
xref: http://identifiers.org/pubmed/6893554
xref: http://identifiers.org/pubmed/9042911
xref: http://identifiers.org/pubmed/18184586
comment: The decarboxylation of orotidine 5'-monophosphate (OMP) to form uridine 5'-monophosphate (UMP) is catalyzed by the orotidine 5'-phosphate decarboxylase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

Evidence151
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8448179
xref: http://identifiers.org/pubmed/7685356
comment: Cytosolic deoxycytidylate deaminase (DCTD) catalyzes the hydrolysis of dCMP (2'-deoxyuridine 5'-monophosphate) to yield dUMP (2'-deoxyuridine 5'-monophosphate) and ammonia. The active enzyme is a homohexamer (Maley et al. 1993; Weiner et al. 1993; unpublished crystallography data - PDB 2W4L).

Evidence152
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11278511
xref: http://identifiers.org/pubmed/2656695
comment: Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).

Evidence153
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/6105839
xref: PublicationXref261
comment: The pyrimidine orotate (orotic acid) is synthesized in a sequence of four reactions, deriving its atoms from glutamine, bicarbonate, and aspartate. A single multifunctional cytosolic enzyme catalyzes the first three of these reactions, while the last one is catalyzed by an enzyme associated with the inner mitochondrial membrane. In two further reactions, catalyzed by a bifunctional cytosolic enzyme, orotate reacts with 1-phosphoribosyl 5-pyrophosphate (PRPP) to yield orotidine 5'-monophosphate, which is decarboxylated to yield uridine 5'-monophosphate (UMP). While several individual reactions in this pathway are reversible, other irreversible reactions drive the pathway in the direction of UMP biosynthesis in the normal cell. All reactions are thus annotated here only in the forward direction. This pathway has been most extensively analyzed at the genetic and biochemical level in hamster cell lines. All three enzymes have also been purified from human sources, however, and the key features of these reactions have been confirmed from studies of this human material (Jones 1980; Webster et al. 2001). All other pyrimidines are synthesized from UMP. The reactions annotaed here, catalyzed by dCMP deaminase and dUTP diphosphatase yield dUMP, which in turn is converted to TMP by thymidylate synthase.

Evidence154
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7284378
xref: http://identifiers.org/pubmed/1590793
xref: http://identifiers.org/pubmed/14725767
comment: Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Evidence155
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11306702
xref: http://identifiers.org/pubmed/195585
comment: Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Unpublished crystallographic data show the enzyme to be a tetramer (PDB - 2JEO).

UniProt:P65415
type: ProteinReference
xref: UnificationXref3048
organism: BioSource1

Evidence146
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2995985
xref: http://identifiers.org/pubmed/4684686
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of N-carbamoyl L-aspartate from carbamoyl phosphate and L-aspartate is catalyzed by the aspartate carbamoyltansferase activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

Evidence145
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/4684686
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of carbamoyl phosphate from glutamine, bicarbonate, and ATP is catalyzed by the carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states, as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

Evidence148
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9693067
xref: http://identifiers.org/pubmed/10889450
xref: http://identifiers.org/pubmed/6105839
xref: http://identifiers.org/pubmed/13115431
xref: http://identifiers.org/pubmed/165196
comment: Dihydroorotate dehydrogenase catalyzes the oxidation of dihydroorotate to orotate (orotic acid). The enzyme is located in the inner mitochondrial membrane oriented so that cytosolic dihydroorotate molecules have access to it, and orotate is released into the cytosol. The reducing equivalents generated by the reaction are transferred by ubiquinone (Coenzyme Q) to the electron transport chain within the inner mitochondrial membrane. There is no evidence for the involvement of NAD+ as an acceptor of reducing equivalents in this reaction in mammalian cells (Jones 1980). In contrast, the reaction catalyzed by the enzyme isolated from the anaerobic bacterium Clostridium oroticum requires NAD+ as a cofactor but also proceeds strongly in the direction of dihydroorotate synthesis consistent with the greater electronegativity of NAD+ (Lieberman and Kornberg 1953). Early studies of purified rat liver enzyme by Forman and Kennedy suggested the presence of flavin mononucleotide and iron-sulfur complexes as cofactors. More recent work by Bader, Beuneu, and their colleagues with recombinant human protein expressed in insect cells has confirmed the presence of flavin mononucleotide, at a stoichiometry of one molecule per molecule of apoenzyme but suggests that iron-sulfur complexes, if indeed they are involved in the oxidation and electron transport process, are not an integral part of the dihydroorotate dehydrogenase holoenzyme.

Evidence147
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8619816
comment: The synthesis of dihydroorotate from N-carbamoyl L-aspartate is catalyzed by the dihydroorotase activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein. This activity has not been directly demonstrated in experimental studies of the purified human protein, but has been inferred from the behavior of the purified hamster protein and the high degree of sequence similarity between the cloned hamster and human genes (Iwahana et al. 1996). Also on the basis of this similarity, the active human protein is annotated as a hexamer (Lee et al. 1985).

http://identifiers.org/pubmed/12151002
type: PublicationXref
id: 12151002
author: Paiement, J
author: Desjardins, M
author: Bergeron, JJ
author: Cameron, PH
author: Duclos, S
author: Chevet, E
author: Gagnon, E
author: Steele-Mortimer, O
author: Rondeau, C
db: Pubmed
title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
source: Cell 110:119-31
year: 2002

Evidence149
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8631878
xref: http://identifiers.org/pubmed/6893554
xref: http://identifiers.org/pubmed/9042911
xref: http://identifiers.org/pubmed/18184586
comment: The synthesis of orotidine 5'-monophosphate (OMP) from orotate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) is catalyzed by the orotate phosphoribosyltransferase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. The reaction itself is freely reversible, but is pulled in the forward direction in vivo by the irreversible hydrolysis of pyrophosphate. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref1004
xref: UnificationXref1003
cellular location: cytosol
comment: Reactome DB_ID: 29420
display name: GDP

CDPethanolamine [ChEBI:3270]
type: SmallMoleculeReference
name: CDPethanolamine
xref: UnificationXref487

AMP, dAMP, GMP, IMP
type: SmallMolecule
data source: Reactome
member physical entity: adenylic acid
member physical entity: deoxyadenylic acid
member physical entity: inosinic acid
member physical entity: Guanosine monophosphate
xref: UnificationXref1065
xref: UnificationXref1066
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500101

adenylic acid
type: SmallMolecule
entity reference: CHEBI:16027
data source: Reactome
name: adenosine 5'-monophosphate
xref: UnificationXref1058
xref: UnificationXref1057
cellular location: extracellular region
comment: Reactome DB_ID: 109275
display name: AMP

Purine-6-ol
type: SmallMolecule
entity reference: CHEBI:17368
data source: Reactome
name: hypoxanthine
xref: UnificationXref1045
xref: UnificationXref1044
cellular location: cytosol
comment: Reactome DB_ID: 113599
display name: Hyp

GMP, IMP
type: SmallMolecule
data source: Reactome
member physical entity: Guanosine monophosphate
member physical entity: Inosine 5'-phosphate
xref: UnificationXref1048
xref: UnificationXref1049
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500260

guanine, hypoxanthine
type: SmallMolecule
data source: Reactome
member physical entity: Purine-6-ol
member physical entity: guanine
xref: UnificationXref1047
xref: UnificationXref1046
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500259

guanine
type: SmallMolecule
entity reference: CHEBI:16235
data source: Reactome
name: 2-amino-6-hydroxypurine
xref: UnificationXref1042
xref: UnificationXref1041
cellular location: cytosol
comment: Reactome DB_ID: 83956
display name: Gua

http://identifiers.org/pubmed/10484781
type: PublicationXref
id: 10484781
author: Petris, MJ
author: Mercer, JF
db: Pubmed
title: The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal
source: Hum Mol Genet 8:2107-15
year: 1999

NH4+
type: SmallMolecule
entity reference: NH4+
data source: Reactome
xref: UnificationXref1024
xref: UnificationXref1025
cellular location: cytosol
comment: Reactome DB_ID: 31633

6-aminopurine
type: SmallMolecule
entity reference: 6-aminopurine
data source: Reactome
name: adenine
xref: UnificationXref1033
xref: UnificationXref1034
cellular location: cytosol
comment: Reactome DB_ID: 83951
display name: Ade

http://identifiers.org/pubmed/10484776
type: PublicationXref
id: 10484776
author: Lin, K
author: Milliner, DS
author: Ferree, PM
author: Holmes, RP
author: Cramer, SD
db: Pubmed
title: The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II
source: Hum Mol Genet 8:2063-9
year: 1999

http://identifiers.org/pubmed/16764946
type: PublicationXref
id: 16764946
author: Catalán, V
author: Frühbeck, G
author: Gómez-Ambrosi, J
author: Rodriguez, A
db: Pubmed
title: Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways
source: Trends Pharmacol Sci 27:345-7
year: 2006

N6-(1,2-Dicarboxyethyl)-AMP
type: SmallMolecule
entity reference: CHEBI:15919
data source: Reactome
name: adenylosuccinate
name: Adenylosuccinic acid
xref: UnificationXref1000
xref: UnificationXref1001
cellular location: cytosol
comment: Reactome DB_ID: 35141
display name: ADS

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref997
xref: UnificationXref998
cellular location: cytosol
comment: Reactome DB_ID: 29438
display name: GTP

http://identifiers.org/pubmed/8644733
type: PublicationXref
id: 8644733
author: Romana, M
author: Moran-Jimenez, MJ
author: D'Alessandro, L
author: Topi, G
author: Enriquez De Salamanca, R
author: de Verneuil, H
author: Taieb, A
author: Ged, C
db: Pubmed
title: Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria
source: Am J Hum Genet 58:712-21
year: 1996

http://identifiers.org/pubmed/19383790
type: PublicationXref
id: 19383790
author: Robbins, RA
author: Chorny, I
author: Miercke, LJ
author: Yeh, R
author: Ho, JD
author: Stroud, RM
author: Harries, WE
author: Sandstrom, A
db: Pubmed
title: Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance
source: Proc Natl Acad Sci U S A 106:7437-42
year: 2009

Acetylcholine Neurotransmitter Release Cycle
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction189
evidence: Evidence316
xref: UnificationXref2307
xref: UnificationXref2308
pathway order: PathwayStep308
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Sulfanilamide
type: SmallMoleculeReference
name: Sulfanilamide [ChEBI:9333]
xref: UnificationXref2127

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI:17345
data source: Reactome
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref1061
xref: UnificationXref1062
cellular location: extracellular region
comment: Reactome DB_ID: 113579
display name: GMP

inosinic acid
type: SmallMolecule
entity reference: CHEBI:17202
data source: Reactome
name: inosine 5'-monophosphate
xref: UnificationXref1063
xref: UnificationXref1064
cellular location: extracellular region
comment: Reactome DB_ID: 109286
display name: IMP

inosine
type: SmallMolecule
entity reference: CHEBI:17596
data source: Reactome
xref: UnificationXref1077
xref: UnificationXref1078
cellular location: extracellular region
comment: Reactome DB_ID: 83921
display name: Ino

inorganic phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
name: phosphate
xref: UnificationXref1081
xref: UnificationXref1082
cellular location: extracellular region
comment: Reactome DB_ID: 109277
display name: Pi

zinc
type: SmallMolecule
entity reference: Zinc [ChEBI:29105]
data source: Reactome
name: Zn(II)
name: Zn++
xref: UnificationXref1086
xref: UnificationXref1085
cellular location: plasma membrane
comment: Reactome DB_ID: 109265
display name: Zn2+

Hydrogen peroxide
type: SmallMolecule
entity reference: CHEBI:16240
data source: Reactome
xref: UnificationXref1091
xref: UnificationXref1092
cellular location: cytosol
comment: Reactome DB_ID: 29408
display name: H2O2

adenosine, deoxyadenosine, guanosine, inosine
type: SmallMolecule
data source: Reactome
member physical entity: guanosine
member physical entity: Adenosine
member physical entity: inosine
member physical entity: 2'-deoxyadenosine
xref: UnificationXref1080
xref: UnificationXref1079
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500104

Adenosine
type: SmallMolecule
entity reference: adenosine
data source: Reactome
xref: UnificationXref1068
xref: UnificationXref1069
cellular location: extracellular region
comment: Reactome DB_ID: 83908
display name: Ade-Rib

2'-deoxyadenosine
type: SmallMolecule
entity reference: CHEBI:17256
data source: Reactome
name: deoxyadenosine
xref: UnificationXref1071
xref: UnificationXref1072
cellular location: extracellular region
comment: Reactome DB_ID: 83919
display name: dA

guanosine
type: SmallMolecule
entity reference: Guanosine
data source: Reactome
xref: UnificationXref1074
xref: UnificationXref1075
cellular location: extracellular region
comment: Reactome DB_ID: 83920
display name: Gua-Rib

http://identifiers.org/pubmed/22074927
type: PublicationXref
id: 22074927
author: von Lintig, Johannes
db: Pubmed
title: Metabolism of carotenoids and retinoids related to vision
source: J. Biol. Chem. 287:1627-34
year: 2012

http://identifiers.org/pubmed/22074928
type: PublicationXref
id: 22074928
author: Kefalov, Vladimir J
db: Pubmed
title: Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches
source: J. Biol. Chem. 287:1635-41
year: 2012

deoxyadenylic acid
type: SmallMolecule
entity reference: 2'-deoxyadenosine 5'-monophosphate [ChEBI:17713]
data source: Reactome
name: 2'-deoxyadenosine 5'-monophosphate
xref: UnificationXref1059
xref: UnificationXref1060
cellular location: extracellular region
comment: Reactome DB_ID: 109295
display name: dAMP

4-hydroxybutyrate
type: SmallMoleculeReference
name: 4-hydroxybutanoate
name: gamma-hydroxybutyrate
name: ChEBI:16724 4-hydroxybutyrate
xref: UnificationXref865

Chenodeoxycholate [ChEBI:16755]
type: SmallMoleculeReference
name: 3alpha,7alpha-Dihydroxy-5beta-cholanic acid
name: Chenodexycholic acid
name: Chenodeoxycholate
xref: UnificationXref327

Guanosine
type: SmallMoleculeReference
name: Guanosine [ChEBI:16750]
xref: UnificationXref1073

Uracil-6-carboxylic acid
type: SmallMoleculeReference
name: Orotic acid
name: Orotate
name: Orotate [ChEBI:16742]
xref: UnificationXref1146

http://identifiers.org/pubmed/9933641
type: PublicationXref
id: 9933641
author: Menon, AG
author: Szabó, EZ
author: Shull, GE
author: Baird, NR
author: Orlowski, J
author: Zaun, HC
author: Schultheis, PJ
db: Pubmed
title: Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain
source: J Biol Chem 274:4377-82
year: 1999

DPN
type: SmallMolecule
entity reference: NAD
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref801
xref: UnificationXref802
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113526
display name: NAD

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Reactome
name: 2-Hydroxytricarballylic acid
name: 2-Hydroxy-1,2,3-propanetricarboxylic acid
name: Citric acid
xref: UnificationXref794
xref: UnificationXref795
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 29654
display name: CIT

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref793
xref: UnificationXref792
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113521
display name: H2O

L-Lactic acid
type: SmallMolecule
entity reference: L-Lactic acid
data source: Reactome
name: L-Lactate
name: (S)-Lactate
xref: UnificationXref771
xref: UnificationXref770
cellular location: cytosol
comment: Reactome DB_ID: 29708
display name: LACT

NADH
type: SmallMolecule
entity reference: NADH
data source: Reactome
xref: UnificationXref768
xref: UnificationXref767
cellular location: cytosol
comment: Reactome DB_ID: 73473

http://identifiers.org/pubmed/13211603
type: PublicationXref
id: 13211603
author: Joklik, WK
author: Berg, P
db: Pubmed
title: Enzymatic phosphorylation of nucleoside diphosphates
source: J Biol Chem 210:657-672
year: 1954

http://identifiers.org/pubmed/1637327
type: PublicationXref
id: 1637327
author: Zimmermann, H
db: Pubmed
title: 5'-nucleotidase: molecular structure and functional aspects
source: Biochem J 285:345-365
year: 1992

5,6,7,8-Tetrahydrobiopterin
type: SmallMolecule
entity reference: 5,6,7,8-Tetrahydrobiopterin
data source: Reactome
name: 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone
name: Tetrahydrobiopterin
xref: UnificationXref746
xref: UnificationXref745
cellular location: cytosol
comment: Reactome DB_ID: 29870
display name: BH4

7,8-dihydrobiopterin
type: SmallMolecule
entity reference: 7,8-Dihydrobiopterin
data source: Reactome
name: dihydrobiopterin
xref: UnificationXref753
xref: UnificationXref754
cellular location: cytosol
comment: Reactome DB_ID: 1497857
display name: BH2

Riboflavin-5-phosphate
type: SmallMolecule
entity reference: FMN [ChEBI:17621]
data source: Reactome
name: Flavin mononucleotide
xref: UnificationXref737
xref: UnificationXref736
cellular location: cytosol
comment: Reactome DB_ID: 73524
display name: FMN

Flavin adenine dinucleotide
type: SmallMolecule
entity reference: CHEBI:16238
data source: Reactome
xref: UnificationXref738
xref: UnificationXref739
cellular location: cytosol
comment: Reactome DB_ID: 29386
display name: FAD

http://identifiers.org/pubmed/10510269
type: PublicationXref
id: 10510269
author: Amodeo, G
author: Ibarra, C
author: Berkowski, D
author: Zotta, E
author: Kierbel, A
author: Bigi, F
author: Silberstein, C
db: Pubmed
title: Functional characterization and localization of AQP3 in the human colon
source: Braz J Med Biol Res 32:1303-13
year: 1999

Zn(II)
type: SmallMolecule
entity reference: Zinc [ChEBI:29105]
data source: Reactome
name: Zn++
name: Zinc ion
xref: UnificationXref731
xref: UnificationXref730
cellular location: cytosol
comment: Reactome DB_ID: 29426
display name: Zn2+

heme (ferrous)
type: SmallMolecule
entity reference: Protoheme
data source: Reactome
xref: UnificationXref733
xref: UnificationXref734
cellular location: cytosol
comment: Reactome DB_ID: 71185
display name: heme

Cytosolic tRNA aminoacylation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction191
evidence: Evidence325
xref: UnificationXref2336
xref: RelationshipXref386
xref: UnificationXref2337
pathway order: PathwayStep316
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

L-Apple acid
type: SmallMolecule
entity reference: CHEBI:30797
data source: Reactome
name: (S)-Malate
name: L-Malate
name: L-2-Hydroxybutanedioic acid
name: L-Malic acid
xref: UnificationXref849
xref: UnificationXref848
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113544
display name: MAL

Fumaric acid
type: SmallMolecule
entity reference: Fumaric acid
data source: Reactome
name: Trans-butenedioic acid
name: Fumarate
xref: UnificationXref846
xref: UnificationXref845
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113588
display name: FUMA

(R)-2-hydroxyglutaric acid
type: SmallMolecule
entity reference: (R)-2-hydroxyglutaric acid
data source: Reactome
name: (R)-2-hydroxyglutarate
xref: UnificationXref863
xref: UnificationXref864
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 879997
display name: 2HG

succinate semialdehyde
type: SmallMolecule
entity reference: CHEBI:16265
data source: Reactome
xref: UnificationXref860
xref: UnificationXref861
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 880046
display name: SUCCSA

'D-Fructose 2,6-bisphosphate [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP'
type: Control
data source: Reactome
xref: UnificationXref79
controlled: Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
control type: ACTIVATION
controller: D-Fructose 2,6-bisphosphate

Thiamin diphosphate
type: SmallMolecule
entity reference: CHEBI:18290
data source: Reactome
name: ThPP
name: Thiamin pyrophosphate
name: TPP
name: Thiamine diphosphate
xref: UnificationXref838
xref: UnificationXref837
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113547
display name: TDP

Lipoamide
type: SmallMolecule
entity reference: CHEBI:17460
data source: Reactome
xref: UnificationXref831
xref: UnificationXref832
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 29824
display name: LIPAM

http://identifiers.org/pubmed/11330046
type: PublicationXref
id: 11330046
author: Zhu, Y
author: Qi, C
author: Reddy, JK
db: Pubmed
title: Peroxisome proliferator-activated receptors, coactivators, and downstream targets
source: Cell Biochem Biophys 32:187-204
year: 2000

http://identifiers.org/pubmed/10889450
type: PublicationXref
id: 10889450
author: Lemaire, G
author: Löffler, M
author: Auger, R
author: Guissani, A
author: Lepoivre, M
author: Beuneu, C
db: Pubmed
title: Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide.
source: Free Radic Biol Med 28:1206-13
year: 2000

Succinyl-CoA
type: SmallMolecule
entity reference: Succinyl-CoA
data source: Reactome
name: Succinyl coenzyme A
xref: UnificationXref822
xref: UnificationXref821
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 70958
display name: SUCC-CoA

'ATP [nucleoplasm]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Reactome
xref: UnificationXref156
controlled: phosphoenolpyruvate + ADP => pyruvate + ATP
control type: INHIBITION
controller: Adenosine 5'-triphosphate

'CIT [cytosol]' negatively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Reactome
xref: UnificationXref101
controlled: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
control type: INHIBITION
controller: Citrate

'3',5'-Cyclic AMP [cytosol]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Reactome
xref: UnificationXref161
controlled: phosphoenolpyruvate + ADP => pyruvate + ATP
control type: INHIBITION
controller: Cyclic AMP

'D-Fructose 1,6-bisphosphate [cytosol]' positively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
type: Control
data source: Reactome
xref: UnificationXref160
controlled: phosphoenolpyruvate + ADP => pyruvate + ATP
control type: ACTIVATION
controller: D-Fructose 1,6-bisphosphate

NADPH
type: SmallMolecule
entity reference: NADPH
data source: Reactome
xref: UnificationXref803
xref: UnificationXref804
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113600
display name: TPNH

'D-Fructose 2,6-bisphosphate [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Reactome
xref: UnificationXref98
controlled: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
control type: ACTIVATION
controller: D-Fructose 2,6-bisphosphate

NADH
type: SmallMolecule
entity reference: NADH
data source: Reactome
xref: UnificationXref806
xref: UnificationXref805
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 29362

'AMP [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Reactome
xref: UnificationXref94
controlled: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
control type: ACTIVATION
controller: 5'-Adenylic acid

NADP+
type: SmallMolecule
entity reference: NADP+
data source: Reactome
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref807
xref: UnificationXref808
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113563
display name: TPN

'ATP [cytosol]' negatively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Reactome
xref: UnificationXref100
controlled: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
control type: INHIBITION
controller: SmallMolecule9

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid
data source: Reactome
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref818
xref: UnificationXref819
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113594
display name: 2OG

'ADP [cytosol]' positively regulates 'D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP'
type: Control
data source: Reactome
xref: UnificationXref99
controlled: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
control type: ACTIVATION
controller: Adenosine 5'-diphosphate

5-phosphoribosylamine
type: SmallMolecule
entity reference: CHEBI:17284
data source: Reactome
name: 5-phospho-D-ribosylamine
name: 5-phosphoribosyl-1-amine
name: 5-phospho-beta-D-ribosylamine
xref: UnificationXref909
xref: UnificationXref908
cellular location: cytosol
comment: Reactome DB_ID: 111292
display name: PRA

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine
data source: Reactome
name: L-2-Aminoglutaramic acid
xref: UnificationXref905
xref: UnificationXref906
cellular location: cytosol
comment: Reactome DB_ID: 29472
display name: L-Gln

Guanosine monophosphate
type: SmallMolecule
entity reference: CHEBI:17345
data source: Reactome
name: Guanosine 5'-phosphate
name: Guanylic acid
name: Guanosine 5'-monophosphate
xref: UnificationXref900
xref: UnificationXref899
cellular location: cytosol
comment: Reactome DB_ID: 113578
display name: GMP

http://identifiers.org/pubmed/11278511
type: PublicationXref
id: 11278511
author: Ding, WC
author: Berger, SH
author: Lebioda, L
author: Koli, S
author: Minor, W
author: Dunlap, RB
author: Phan, J
author: Steadman, DJ
db: Pubmed
title: Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
source: J Biol Chem 276:14170-7
year: 2001

10-formyltetrahydrofolate
type: SmallMolecule
entity reference: 10-Formyl-THF
data source: Reactome
xref: UnificationXref929
xref: UnificationXref928
cellular location: cytosol
comment: Reactome DB_ID: 419151
display name: 10-formyl-THF

Glycinamide ribonucleotide
type: SmallMolecule
entity reference: 5-phosphoribosylglycinamide [ChEBI:18349]
data source: Reactome
name: 5-phosphoribosylglycinamide
name: PRGA
name: N1-(5-Phospho-D-ribosyl)glycinamide
xref: UnificationXref922
xref: UnificationXref921
cellular location: cytosol
comment: Reactome DB_ID: 111338
display name: GAR

L-glycine
type: SmallMolecule
entity reference: Gly
data source: Reactome
name: Aminoacetic acid
xref: UnificationXref919
xref: UnificationXref918
cellular location: cytosol
comment: Reactome DB_ID: 29424
display name: Gly

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Reactome
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref912
xref: UnificationXref911
cellular location: cytosol
comment: Reactome DB_ID: 29404
display name: L-Glu

http://identifiers.org/pubmed/10625641
type: PublicationXref
id: 10625641
author: Lopez-Jimenez, M
author: Ramesh, B
author: Srai, SK
author: Dedes, M
author: Williams, M
author: Leggett, A
author: Sharp, P
author: Tandy, S
db: Pubmed
title: Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells
source: J Biol Chem 275:1023-9
year: 2000

sulfur
type: SmallMolecule
entity reference: Sulfur
data source: Reactome
xref: UnificationXref885
xref: UnificationXref884
cellular location: cytosol
comment: Reactome DB_ID: 111284
display name: S

Inosine 5'-phosphate
type: SmallMolecule
entity reference: CHEBI:17202
data source: Reactome
name: Inosine monophosphate
name: 5'-Inosine monophosphate
name: 5'-Inosinic acid
name: 5'-Inosinate
name: Inosinic acid
name: Inosine 5'-monophosphate
xref: UnificationXref895
xref: UnificationXref894
cellular location: cytosol
comment: Reactome DB_ID: 29602
display name: IMP

4-hydroxybutyrate
type: SmallMolecule
entity reference: 4-hydroxybutyrate
data source: Reactome
xref: UnificationXref867
xref: UnificationXref866
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 880041
display name: HBUT

Fe(III)
type: SmallMolecule
entity reference: CHEBI:18248
data source: Reactome
name: iron (ferrous)
name: Fe3+
name: Fe(II)
name: Iron
name: Fe++
xref: UnificationXref882
xref: UnificationXref881
cellular location: cytosol
comment: Reactome DB_ID: 71067
display name: Fe2+

1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
type: SmallMolecule
entity reference: 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
data source: Reactome
name: 5'-phosphoribosyl-5-amino-4-imidazolecarboxylate
xref: UnificationXref947
xref: UnificationXref948
cellular location: cytosol
comment: Reactome DB_ID: 111395
display name: CAIR

5'-phosphoribosyl-5-aminoimidazole
type: SmallMolecule
entity reference: 5'-Phosphoribosyl-5-aminoimidazole [ChEBI:28843]
data source: Reactome
name: Aminoimidazole ribotide
name: 1-(5'-Phosphoribosyl)-5-aminoimidazole
name: 1-(5-Phospho-D-ribosyl)-5-aminoimidazole
xref: UnificationXref943
xref: UnificationXref942
cellular location: cytosol
comment: Reactome DB_ID: 111370
display name: AIR

5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide
type: SmallMolecule
entity reference: 1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole
data source: Reactome
xref: UnificationXref959
xref: UnificationXref958
cellular location: cytosol
comment: Reactome DB_ID: 111399
display name: SAICAR

L-Aspartate
type: SmallMolecule
entity reference: CHEBI:17053
data source: Reactome
name: 2-aminosuccinate
xref: UnificationXref955
xref: UnificationXref956
cellular location: cytosol
comment: Reactome DB_ID: 29448
display name: L-Asp

http://identifiers.org/pubmed/6372096
type: PublicationXref
id: 6372096
author: Horwich, AL
author: Doolittle, RF
author: Rosenberg, LE
author: Fenton, WA
author: Konigsberg, W
author: Kalousek, F
author: Williams, KR
author: Kraus, JP
db: Pubmed
title: Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase.
source: Science 224:1068-74
year: 1984

5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
type: SmallMolecule
entity reference: CHEBI:18406
data source: Reactome
xref: UnificationXref967
xref: UnificationXref966
cellular location: cytosol
comment: Reactome DB_ID: 111409
display name: AICAR

Fumarate
type: SmallMolecule
entity reference: ChEBI:37154 fumarate(1-)
data source: Reactome
xref: UnificationXref964
xref: UnificationXref963
cellular location: cytosol
comment: Reactome DB_ID: 29586
display name: FUMA

xanthosine 5'-monophosphate
type: SmallMolecule
entity reference: XMP
data source: Reactome
name: xanthylic acid
xref: UnificationXref984
xref: UnificationXref985
cellular location: cytosol
comment: Reactome DB_ID: 111584
display name: XMP

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
type: SmallMolecule
entity reference: 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
data source: Reactome
xref: UnificationXref975
xref: UnificationXref974
cellular location: cytosol
comment: Reactome DB_ID: 111427
display name: FAICAR

http://identifiers.org/pubmed/1851158
type: PublicationXref
id: 1851158
author: Lascu, I
author: Presecan, E
author: Gilles, AM
author: Vonica, A
db: Pubmed
title: Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme
source: J Biol Chem 266:8784-8789
year: 1991

Neurotransmitter Clearance In The Synaptic Cleft
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction36
evidence: Evidence318
xref: RelationshipXref380
xref: UnificationXref2311
xref: UnificationXref2312
pathway order: PathwayStep63
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/8617223
type: PublicationXref
id: 8617223
author: Cole, TB
author: Findley, SD
author: Palmiter, RD
db: Pubmed
title: ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
source: EMBO J 15:1784-91
year: 1996

6-aminopurine
type: SmallMoleculeReference
name: adenine [ChEBI:16708]
name: adenine
xref: UnificationXref1032

http://identifiers.org/pubmed/8626466
type: PublicationXref
id: 8626466
author: Toth, MJ
author: Huwyler, L
db: Pubmed
title: Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase
source: J Biol Chem 271:7895-8
year: 1996

Uridine [ChEBI:16704]
type: SmallMoleculeReference
name: Uridine
xref: UnificationXref1223

N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
type: SmallMolecule
entity reference: CHEBI:18272
data source: Reactome
name: N-Formylglycinamide ribonucleotide
name: 5'-phosphoribosyl-N-formylglycinamide
xref: UnificationXref931
xref: UnificationXref932
cellular location: cytosol
comment: Reactome DB_ID: 111354
display name: N-Formyl-GAR

5,6,7,8-tetrahydrofolate
type: SmallMolecule
entity reference: 5,6,7,8-Tetrahydrofolate
data source: Reactome
name: Tetrahydrofolate
name: tetrahydrofolic acid
xref: UnificationXref935
xref: UnificationXref934
cellular location: cytosol
comment: Reactome DB_ID: 111355
display name: THF

2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: SmallMolecule
entity reference: CHEBI:18413
data source: Reactome
name: 1-(5'-Phosphoribosyl)-N-formylglycinamidine
name: 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
name: 5'-Phosphoribosyl-N-formylglycinamidine
name: 5'-phosphoribosylformylglycinamidine
xref: UnificationXref939
xref: UnificationXref940
cellular location: cytosol
comment: Reactome DB_ID: 111369
display name: FGAM

http://identifiers.org/pubmed/21781017
type: PublicationXref
id: 21781017
author: Pulimeno, P
author: Stutz, J
author: Spadaro, D
author: Schneider, Y
author: Citi, S
db: Pubmed
title: Regulation of small GTPases at epithelial cell-cell junctions
source: Mol Membr Biol
year: 2011

UnificationXref738
type: UnificationXref
id: 29386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386

UnificationXref737
type: UnificationXref
id: REACT_3399
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3399.2

UnificationXref736
type: UnificationXref
id: 73524
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73524

UnificationXref735
type: UnificationXref
id: CHEBI:17621
db: ChEBI

UnificationXref734
type: UnificationXref
id: REACT_2784
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2784.3

UnificationXref733
type: UnificationXref
id: 71185
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71185

UnificationXref732
type: UnificationXref
id: CHEBI:17627
db: ChEBI

UnificationXref731
type: UnificationXref
id: REACT_3201
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3201.3

http://identifiers.org/pubmed/13115431
type: PublicationXref
id: 13115431
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
source: Biochim Biophys Acta 12:223-234
year: 1953

uridine 5'-diphosphate
type: SmallMolecule
entity reference: UDP
data source: Reactome
xref: UnificationXref1304
xref: UnificationXref1305
cellular location: cytosol
comment: Reactome DB_ID: 110096
display name: UDP

Cytidine diphosphate
type: SmallMolecule
entity reference: CHEBI:17239
data source: Reactome
name: cytidine 5'-diphosphate
xref: UnificationXref1302
xref: UnificationXref1301
cellular location: cytosol
comment: Reactome DB_ID: 110094
display name: CDP

Antigen Presentation: Folding, assembly and peptide loading of class I MHC
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction261
evidence: Evidence434
xref: UnificationXref3016
xref: UnificationXref3017
pathway order: PathwayStep420
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

(deoxy)nucleotide diphosphates
type: SmallMolecule
data source: Reactome
member physical entity: uridine 5'-diphosphate
member physical entity: 2'-Deoxycytidine diphosphate
member physical entity: dTDP
member physical entity: Cytidine diphosphate
member physical entity: 2'-deoxyadenosine 5'-diphosphate
member physical entity: Guanosine 5'-diphosphate
member physical entity: 2'-deoxyuridine 5'-diphosphate
member physical entity: 2'-deoxyguanosine 5'-diphosphate
xref: UnificationXref1318
xref: UnificationXref1319
cellular location: cytosol
comment: Reactome DB_ID: 482627
comment: Converted from EntitySet in Reactome
display name: (d)NDP

2'-deoxyguanosine 5'-diphosphate
type: SmallMolecule
entity reference: 2'-Deoxyguanosine 5'-diphosphate
data source: Reactome
xref: UnificationXref1291
xref: UnificationXref1290
cellular location: cytosol
comment: Reactome DB_ID: 110092
display name: dGDP

(d)GDP
type: SmallMolecule
data source: Reactome
member physical entity: Guanosine 5'-diphosphate
member physical entity: 2'-deoxyguanosine 5'-diphosphate
xref: UnificationXref1293
xref: UnificationXref1292
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500077

UnificationXref739
type: UnificationXref
id: REACT_4227
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4227.1

deoxyguanylic acid
type: SmallMolecule
entity reference: dGMP
data source: Reactome
name: 2'-deoxyguanosine 5'-monophosphate
xref: UnificationXref1285
xref: UnificationXref1286
cellular location: cytosol
comment: Reactome DB_ID: 109327
display name: dGMP

2'-deoxyuridine 5'-diphosphate
type: SmallMolecule
entity reference: dUDP [ChEBI:28850]
data source: Reactome
xref: UnificationXref1316
xref: UnificationXref1317
cellular location: cytosol
comment: Reactome DB_ID: 110093
display name: dUDP

(deoxy)nucleotide triphosphates
type: SmallMolecule
data source: Reactome
member physical entity: dTTP
member physical entity: 2'-deoxyadenosine 5'-triphosphate
member physical entity: uridine 5'-triphosphate
member physical entity: cytidine 5'-triphosphate
member physical entity: deoxycytidine 5'-triphosphate
member physical entity: 2'-deoxyuridine 5'-triphosphate
member physical entity: 2'-deoxyguanosine 5'-triphosphate
member physical entity: Guanosine 5'-triphosphate
xref: UnificationXref1336
xref: UnificationXref1335
cellular location: cytosol
comment: Reactome DB_ID: 482625
comment: Converted from EntitySet in Reactome
display name: (d)NTP

2'-Deoxycytidine diphosphate
type: SmallMolecule
entity reference: dCDP
data source: Reactome
name: 2'-deoxycytidine 5'-diphosphate
xref: UnificationXref1311
xref: UnificationXref1310
cellular location: cytosol
comment: Reactome DB_ID: 110091
display name: dCDP

dTDP
type: SmallMolecule
entity reference: dTDP
data source: Reactome
name: thymidine 5'-diphosphate
name: deoxythymidine 5'-diphosphate
xref: UnificationXref1314
xref: UnificationXref1313
cellular location: cytosol
comment: Reactome DB_ID: 110095
display name: TDP

2'-deoxyadenosine 5'-diphosphate
type: SmallMolecule
entity reference: 2'-deoxyadenosine 5'-diphosphate
data source: Reactome
xref: UnificationXref1308
xref: UnificationXref1307
cellular location: cytosol
comment: Reactome DB_ID: 110090
display name: dADP

N-Hydroxy-4-aminobiphenyl
type: SmallMoleculeReference
name: N-Hydroxy-4-aminobiphenyl [ChEBI:16580]
xref: UnificationXref2118

UnificationXref730
type: UnificationXref
id: 29426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426

delta3-methyl-3-butenyl diphosphate
type: SmallMoleculeReference
name: delta3-Isopentenyl diphosphate
name: Isopentenyl diphosphate [ChEBI:6037]
name: Isopentenyl diphosphate
xref: UnificationXref456

http://identifiers.org/pubmed/20188572
type: PublicationXref
id: 20188572
author: von Lintig, Johannes
author: Palczewski, Krzysztof
author: Kiser, Philip D
author: Golczak, Marcin
db: Pubmed
title: The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
source: Trends Biochem. Sci. 35:400-10
year: 2010

UnificationXref725
type: UnificationXref
id: 4230611
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230611

UnificationXref724
type: UnificationXref
id: 4230602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230602

UnificationXref727
type: UnificationXref
id: MOD:00115
db: MOD

UnificationXref726
type: UnificationXref
id: REACT_157164
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157164.3

UnificationXref721
type: UnificationXref
id: 184174
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=184174

UnificationXref720
type: UnificationXref
id: CHEBI:15532
db: ChEBI

UnificationXref723
type: UnificationXref
id: MOD:00068
db: MOD

UnificationXref722
type: UnificationXref
id: REACT_13331
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13331.2

uridine 5'-monophosphate
type: SmallMolecule
entity reference: Uridine 5'-monophosphate
data source: Reactome
name: uridylic acid
name: U5MP
xref: UnificationXref1264
xref: UnificationXref1265
cellular location: extracellular region
comment: Reactome DB_ID: 109280
display name: UMP

thymidylic acid
type: SmallMolecule
entity reference: CHEBI:17013
data source: Reactome
name: thymidine 5'-monophosphate
xref: UnificationXref1262
xref: UnificationXref1263
cellular location: extracellular region
comment: Reactome DB_ID: 109292
display name: TMP

cytidine, thymidine, uridine
type: SmallMolecule
data source: Reactome
member physical entity: uridine
member physical entity: thymidine
member physical entity: cytidine
xref: UnificationXref1275
xref: UnificationXref1274
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500318

UnificationXref729
type: UnificationXref
id: CHEBI:29105
db: ChEBI

(deoxy)uridine
type: SmallMolecule
data source: Reactome
member physical entity: 2-Deoxyuridine
member physical entity: uridine
xref: UnificationXref1251
xref: UnificationXref1252
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500430

UnificationXref728
type: UnificationXref
id: 4230609
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230609

Deoxycytidine
type: SmallMolecule
entity reference: Deoxycytidine [ChEBI:15698]
data source: Reactome
name: 2'-deoxycytidine
xref: UnificationXref1247
xref: UnificationXref1248
cellular location: cytosol
comment: Reactome DB_ID: 109379
display name: dC

http://identifiers.org/pubmed/22952392
type: PublicationXref
id: 22952392
author: Nusse, Roel
author: Willert, Karl
db: Pubmed
title: Wnt proteins
source: Cold Spring Harb Perspect Biol 4:a007864
year: 2012

cytidine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17361
data source: Reactome
name: cytidylic acid
xref: UnificationXref1261
xref: UnificationXref1260
cellular location: extracellular region
comment: Reactome DB_ID: 109289
display name: CMP

CMP, TMP. UMP
type: SmallMolecule
data source: Reactome
member physical entity: uridine 5'-monophosphate
member physical entity: cytidine 5'-monophosphate
member physical entity: thymidylic acid
xref: UnificationXref1266
xref: UnificationXref1267
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500316

cytidine
type: SmallMolecule
entity reference: CHEBI:17562
data source: Reactome
xref: UnificationXref1269
xref: UnificationXref1268
cellular location: extracellular region
comment: Reactome DB_ID: 83948
display name: Cyt-Rib

thymidine
type: SmallMolecule
entity reference: Deoxythymidine
data source: Reactome
name: 2'-deoxythymidine
xref: UnificationXref1270
xref: UnificationXref1271
cellular location: extracellular region
comment: Reactome DB_ID: 83922
display name: Thy-dRib

uridine
type: SmallMolecule
entity reference: Uridine [ChEBI:16704]
data source: Reactome
xref: UnificationXref1273
xref: UnificationXref1272
cellular location: extracellular region
comment: Reactome DB_ID: 83923
display name: Ura-Rib

(d)GMP
type: SmallMolecule
data source: Reactome
member physical entity: Guanosine monophosphate
member physical entity: deoxyguanylic acid
xref: UnificationXref1288
xref: UnificationXref1287
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500071

UnificationXref712
type: UnificationXref
id: 4231439
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231439

UnificationXref711
type: UnificationXref
id: REACT_163461
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_163461.2

UnificationXref710
type: UnificationXref
id: 4231197
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231197

UnificationXref716
type: UnificationXref
id: 4231313
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231313

UnificationXref715
type: UnificationXref
id: REACT_98784
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_98784.9

UnificationXref714
type: UnificationXref
id: 4231291
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231291

UnificationXref713
type: UnificationXref
id: REACT_162092
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_162092.2

Deoxythymidine
type: SmallMolecule
entity reference: Deoxythymidine
data source: Reactome
name: thymidine
name: 2'-deoxythymidine
xref: UnificationXref1208
xref: UnificationXref1209
cellular location: cytosol
comment: Reactome DB_ID: 83928
display name: Thy-dRib

UnificationXref719
type: UnificationXref
id: REACT_155415
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155415.3

thymidine, deoxyuridine
type: SmallMolecule
data source: Reactome
member physical entity: Deoxythymidine
member physical entity: 2-Deoxyuridine
xref: UnificationXref1214
xref: UnificationXref1213
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500444

UnificationXref718
type: UnificationXref
id: 4231314
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231314

uracil
type: SmallMolecule
entity reference: CHEBI:17568
data source: Reactome
xref: UnificationXref1203
xref: UnificationXref1204
cellular location: cytosol
comment: Reactome DB_ID: 83962
display name: Ura

UnificationXref717
type: UnificationXref
id: REACT_158416
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158416.3

thymine
type: SmallMolecule
entity reference: Thymine
data source: Reactome
xref: UnificationXref1200
xref: UnificationXref1201
cellular location: cytosol
comment: Reactome DB_ID: 83960
display name: Thy

http://identifiers.org/pubmed/5324173
type: PublicationXref
id: 5324173
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Transfer ribonucleic acid-induced hydrolysis of valyladenylate bound to isoleucyl ribonucleic acid synthetase
source: J Biol Chem 241:839-45
year: 1966

uridine
type: SmallMolecule
entity reference: Uridine [ChEBI:16704]
data source: Reactome
xref: UnificationXref1225
xref: UnificationXref1224
cellular location: cytosol
comment: Reactome DB_ID: 83929
display name: Ura-Rib

cytidine
type: SmallMolecule
entity reference: CHEBI:17562
data source: Reactome
xref: UnificationXref1221
xref: UnificationXref1222
cellular location: cytosol
comment: Reactome DB_ID: 83949
display name: Cyt-Rib

cytidine, uridine
type: SmallMolecule
data source: Reactome
member physical entity: cytidine
member physical entity: uridine
xref: UnificationXref1227
xref: UnificationXref1226
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500759

http://identifiers.org/pubmed/5324172
type: PublicationXref
id: 5324172
author: Berg, P
author: Baldwin, AN
db: Pubmed
title: Purification and properties of isoleucyl ribonucleic acid synthetase from Escherichia coli
source: J Biol Chem 241:831-8
year: 1966

2-Deoxyuridine
type: SmallMolecule
entity reference: 2'-Deoxyuridine
data source: Reactome
name: 2'-deoxyuridine
name: Deoxyuridine
xref: UnificationXref1211
xref: UnificationXref1212
cellular location: cytosol
comment: Reactome DB_ID: 109383
display name: dU

Cytidine-5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:17361
data source: Reactome
name: cytidine 5'-monophosphate
name: cytidylic acid
xref: UnificationXref1230
xref: UnificationXref1229
cellular location: cytosol
comment: Reactome DB_ID: 109395
display name: CMP

(deoxy)cytidine
type: SmallMolecule
data source: Reactome
member physical entity: cytidine
member physical entity: Deoxycytidine
xref: UnificationXref1249
xref: UnificationXref1250
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500829

CMP, UMP
type: SmallMolecule
data source: Reactome
member physical entity: Cytidine-5'-monophosphate
member physical entity: uridine 5'-monophosphate
xref: UnificationXref1232
xref: UnificationXref1231
cellular location: cytosol
comment: Reactome DB_ID: 500761
comment: Converted from EntitySet in Reactome

2-Amino-1,3-dihydroxyoctadecane
type: SmallMoleculeReference
name: Dihydrosphingosine
name: Sphinganine [ChEBI:9221]
name: Sphinganine
xref: UnificationXref665

Deoxythymidylic acid
type: SmallMolecule
entity reference: CHEBI:17013
data source: Reactome
name: dTMP
name: thymidylic acid
name: Thymidylate
name: 5'-Thymidylic acid
name: Thymidine 5'-phosphate
name: Deoxythymidine 5'-phosphate
name: thymidine 5'-monophosphate
name: Thymidine monophosphate
xref: UnificationXref1187
xref: UnificationXref1188
cellular location: cytosol
comment: Reactome DB_ID: 109366
display name: TMP

UnificationXref701
type: UnificationXref
id: REACT_5847
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5847.1

UnificationXref700
type: UnificationXref
id: 113529
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529

UnificationXref703
type: UnificationXref
id: 2162204
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162204

UnificationXref702
type: UnificationXref
id: CHEBI:64181
db: ChEBI

UnificationXref705
type: UnificationXref
id: CHEBI:16680
db: ChEBI

UnificationXref704
type: UnificationXref
id: REACT_161541
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161541.1

UnificationXref707
type: UnificationXref
id: REACT_161327
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_161327.1

flavin mononucleotide
type: SmallMolecule
entity reference: FMN [ChEBI:17621]
data source: Reactome
name: riboflavin-5-phosphate
xref: UnificationXref1151
xref: UnificationXref1152
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 76629
display name: FMN

http://identifiers.org/pubmed/1592113
type: PublicationXref
id: 1592113
author: Powell, SM
author: Dixon, JE
author: Zalkin, H
db: Pubmed
title: Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase
source: FEBS Lett 303:4-20
year: 1992

UnificationXref706
type: UnificationXref
id: 2162252
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2162252

uracil-6-carboxylic acid
type: SmallMolecule
entity reference: Uracil-6-carboxylic acid
data source: Reactome
name: orotic acid
xref: UnificationXref1147
xref: UnificationXref1148
cellular location: cytosol
comment: Reactome DB_ID: 76632
display name: orotate

UnificationXref709
type: UnificationXref
id: 4231195
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231195

uridine 5'-monophosphate
type: SmallMolecule
entity reference: Uridine 5'-monophosphate
data source: Reactome
name: Uridine monophosphate
name: uridylic acid
name: 5'Uridylic acid
xref: UnificationXref1166
xref: UnificationXref1165
cellular location: cytosol
comment: Reactome DB_ID: 109402
display name: UMP

UnificationXref708
type: UnificationXref
id: P67062
db: UniProt

orotidine 5'-monophosphate
type: SmallMolecule
entity reference: Orotidine 5'-phosphate [ChEBI:15842]
data source: Reactome
name: orotidine 5'-phosphate
xref: UnificationXref1158
xref: UnificationXref1157
cellular location: cytosol
comment: Reactome DB_ID: 111629
display name: orotidylic acid

http://identifiers.org/pubmed/15784477
type: PublicationXref
id: 15784477
author: Cynober, L
author: Moinard, C
author: de Bandt, JP
db: Pubmed
title: Polyamines: metabolism and implications in human diseases
source: Clin Nutr 24:184-97
year: 2005

2'-Deoxyuridine 5'-phosphate
type: SmallMolecule
entity reference: 2'-Deoxyuridine 5'-phosphate
data source: Reactome
name: Deoxyuridine monophosphate
name: Deoxyuridine 5'-phosphate
name: 2'-deoxyuridine 5'-monophosphate
name: deoxyuridylic acid
xref: UnificationXref1173
xref: UnificationXref1174
cellular location: cytosol
comment: Reactome DB_ID: 109382
display name: dUMP

2'-deoxycytidine 5'-monophosphate
type: SmallMolecule
entity reference: CHEBI:15918
data source: Reactome
name: Deoxycytidine monophosphate
name: Deoxycytidylate
name: deoxycytidylic acid
xref: UnificationXref1170
xref: UnificationXref1171
cellular location: cytosol
comment: Reactome DB_ID: 109378
display name: dCMP

7,8-Dihydrofolic acid
type: SmallMolecule
entity reference: Dihydrofolate [ChEBI:15633]
data source: Reactome
name: Dihydrofolic acid
name: Dihydrofolate
name: 7,8-Dihydrofolate
xref: UnificationXref1184
xref: UnificationXref1185
cellular location: cytosol
comment: Reactome DB_ID: 73604
display name: DHF

Ammonia
type: SmallMolecule
entity reference: Ammonia
data source: Reactome
xref: UnificationXref1176
xref: UnificationXref1177
cellular location: cytosol
comment: Reactome DB_ID: 29382
display name: NH3

Tryptophan catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction145
pathway component: BiochemicalReaction144
evidence: Evidence229
xref: UnificationXref1774
xref: UnificationXref1773
xref: RelationshipXref281
pathway order: PathwayStep224
pathway order: PathwayStep225
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

2-deoxy-D-ribose 1-phosphate
type: SmallMolecule
entity reference: 2-Deoxy-D-ribose 1-phosphate
data source: Reactome
xref: UnificationXref1198
xref: UnificationXref1197
cellular location: cytosol
comment: Reactome DB_ID: 112032
display name: dRibP

thymine, uracil
type: SmallMolecule
data source: Reactome
member physical entity: uracil
member physical entity: thymine
xref: UnificationXref1206
xref: UnificationXref1205
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 500438

carbamoyl phosphate
type: SmallMolecule
entity reference: Carbamoyl phosphate [ChEBI:17672]
data source: Reactome
xref: UnificationXref1120
xref: UnificationXref1119
cellular location: cytosol
comment: Reactome DB_ID: 111647
display name: CAP

N-carbamoyl-L-aspartate
type: SmallMolecule
entity reference: N-Carbamoyl-L-aspartate
data source: Reactome
xref: UnificationXref1131
xref: UnificationXref1130
cellular location: cytosol
comment: Reactome DB_ID: 111628

protoheme
type: SmallMolecule
entity reference: Protoheme
data source: Reactome
xref: UnificationXref1103
xref: UnificationXref1104
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 113569
display name: heme

hydrogencarbonate
type: SmallMolecule
entity reference: CHEBI:17544
data source: Reactome
name: acid carbonate
name: bicarbonate
xref: UnificationXref1116
xref: UnificationXref1117
cellular location: cytosol
comment: Reactome DB_ID: 111627
display name: HCO3-

Oxygen
type: SmallMolecule
entity reference: Oxygen
data source: Reactome
xref: UnificationXref1099
xref: UnificationXref1100
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 113535
display name: O2

NADPH
type: SmallMolecule
entity reference: NADPH
data source: Reactome
xref: UnificationXref1102
xref: UnificationXref1101
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 113602
display name: TPNH

Hydrogen peroxide
type: SmallMolecule
entity reference: CHEBI:16240
data source: Reactome
xref: UnificationXref1095
xref: UnificationXref1096
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 113575
display name: H2O2

H2O
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref1098
xref: UnificationXref1097
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 141343

http://identifiers.org/pubmed/7802672
type: PublicationXref
id: 7802672
author: Qureshi, IA
author: Mawal, YR
db: Pubmed
title: Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver
source: Biochem Biophys Res Commun 205:1373-9
year: 1994

http://identifiers.org/pubmed/18400693
type: PublicationXref
id: 18400693
author: Dorwart, MR
author: Muallem, S
author: Yang, D
author: Shcheynikov, N
db: Pubmed
title: The solute carrier 26 family of proteins in epithelial ion transport
source: Physiology (Bethesda) 23:104-14
year: 2008

(S)-4,5-dihydroorotate
type: SmallMolecule
entity reference: CHEBI:17025
data source: Reactome
name: L-dihydroorotic acid
name: dihydro-L-orotic acid
name: (S)-dihydroorotate
xref: UnificationXref1135
xref: UnificationXref1136
cellular location: cytosol
comment: Reactome DB_ID: 76630
display name: L-dihydroorotate

Coenzyme Q
type: SmallMolecule
entity reference: CoQ
data source: Reactome
name: CoQ
name: ubiquinone
xref: UnificationXref1142
xref: UnificationXref1141
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 73663
display name: Q

Coenzyme QH2
type: SmallMolecule
entity reference: Coenzyme QH2
data source: Reactome
name: CoQH2
name: ubiquinol
xref: UnificationXref1145
xref: UnificationXref1144
cellular location: mitochondrial inner membrane
comment: Reactome DB_ID: 76633
display name: QH2

http://identifiers.org/pubmed/2462567
type: PublicationXref
id: 2462567
author: de Jong, WW
author: Stapel, SO
author: Lietman, T
author: Wistow, GJ
author: Piatigorsky, J
author: Williams, LA
author: Horwitz, J
db: Pubmed
title: Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein
source: J Cell Biol 107:2729-36
year: 1988

http://identifiers.org/pubmed/12668600
type: PublicationXref
id: 12668600
author: Herman, GE
db: Pubmed
title: Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes
source: Hum Mol Genet 12:R75-88
year: 2003

http://identifiers.org/pubmed/21220505
type: PublicationXref
id: 21220505
author: Langer, T
author: Voelker, DR
author: Osman, C
db: Pubmed
title: Making heads or tails of phospholipids in mitochondria
source: J Cell Biol 192:7-16
year: 2011

http://identifiers.org/pubmed/12324224
type: PublicationXref
id: 12324224
author: Sprecher, H
db: Pubmed
title: The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids
source: Prostaglandins Leukot Essent Fatty Acids 67:79-83
year: 2002

CO2 [ChEBI:16526]
type: SmallMoleculeReference
name: CO2
name: Carbon dioxide
xref: UnificationXref174

http://identifiers.org/pubmed/11231887
type: PublicationXref
id: 11231887
author: Fischer, H
author: Lindblom, A
author: Rubio, C
author: Stenling, R
db: Pubmed
title: Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors
source: BMC Physiol 1:1
year: 2001

Passive Transport by Aquaporins
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction247
pathway component: BiochemicalReaction249
pathway component: BiochemicalReaction248
pathway component: BiochemicalReaction246
pathway component: BiochemicalReaction250
pathway component: BiochemicalReaction245
evidence: Evidence402
xref: UnificationXref2902
xref: UnificationXref2901
xref: RelationshipXref472
pathway order: PathwayStep389
pathway order: PathwayStep392
pathway order: PathwayStep391
pathway order: PathwayStep390
pathway order: PathwayStep387
pathway order: PathwayStep388
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11371164
type: PublicationXref
id: 11371164
author: Li, X
author: Davies, C
author: Pearce, J
author: Muirhead, H
author: Chirgwin, J
author: Read, J
db: Pubmed
title: The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia
source: J Mol Biol 309:447-63
year: 2001

5,10-methylenetetrahydrofolate polyglutamate
type: SmallMoleculeReference
name: 5,10-methylenetetrahydrofolate polyglutamate macromolecule
name: 5,10-methylenetetrahydrofolate polyglutamate macromolecule [ChEBI:60473]
xref: UnificationXref1542

2-Oxoisopentanoate
type: SmallMoleculeReference
name: 2-Oxoisovalerate
name: 2-Oxo-3-methylbutanoate
name: alpha-Ketovaline
name: 3-Methyl-2-oxobutanoate
name: 2-Keto-3-methylbutyric acid
name: 2-Ketovaline
name: 3-Methyl-2-oxobutanoate [ChEBI:16530]
name: 3-Methyl-2-oxobutyric acid
xref: UnificationXref1638

http://identifiers.org/pubmed/16968948
type: PublicationXref
id: 16968948
author: Brink, C
author: Serhan, CN
author: Shimizu, T
author: Rovati, GE
author: Hay, DW
author: Yokomizo, T
author: Chiang, N
author: Drazen, JM
author: Dahlén, SE
db: Pubmed
title: The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo
source: Pharmacol Rev 58:463-87
year: 2006

4-Trimethylammoniobutanal
type: SmallMoleculeReference
name: 4-Trimethylammoniobutanal [ChEBI:18020]
xref: UnificationXref1834

Phosphoenolpyruvic acid
type: SmallMoleculeReference
name: Phosphoenolpyruvate
name: Phosphoenolpyruvate [ChEBI:18021]
name: PEP
xref: UnificationXref136

http://identifiers.org/pubmed/2026611
type: PublicationXref
id: 2026611
author: Eriksson, S
author: Tyrsted, G
author: Munch-Petersen, B
author: Cloos, L
db: Pubmed
title: Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides
source: J Biol Chem 266:9032-9038
year: 1991

Evidence349
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12750889
comment: The SLC34 family of type II Na+/Pi cotransporters consist of three members; NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2) and NaPi-IIc (SLC34A3) (Murer H et al, 2004). They are expressed mainly in the kidney and small intestine, located at the apical sites of epithelial cells although other areas of the body express them to a lesser extent. NaPi-IIa and b cotransports divalent Pi (HPO4[2-]) with three Na+ ions (electrogenic transport) whereas NaPi-IIc cotransports divalent Pi with two Na+ ions (electroneutral transport).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67579
data source: Reactome
name: Methionyl-tRNA synthetase 2
name: P67579
xref: UnificationXref2432
feature: FragmentFeature179
cellular location: intracellular
comment: Reactome DB_ID: 4230689
display name: MARS2

P68848
type: Protein
entity reference: P68848
data source: Reactome
xref: UnificationXref2445
cellular location: intracellular
comment: Reactome DB_ID: 4230715

Evidence347
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10329428
xref: http://identifiers.org/pubmed/12324554
xref: http://identifiers.org/pubmed/8327470
xref: http://identifiers.org/pubmed/16960801
comment: SLC34A1 encodes Na+/Pi cotransporter (NaPi-IIa) which is expressed in the kidney in the renal proximal tubule (Magagnin S et al, 1993). SLC34A2 encodes NaPi-IIb which is abundantly expressed in lung and to a lesser degree in tissues of epithelial origin including small intestine, pancreas, prostate, and kidney (Field JA et al, 1999). Both NaPi-IIa and NaPi-IIb cotransport divalent Pi (HPO4[2-]) with three Na+ ions (electrogenic transport). Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1) (Prie D et al, 2002). Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (Corut A et al, 2006).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5Y3
data source: Reactome
name: Prolyl-tRNA synthetase 2
name: Q7A5Y3
xref: UnificationXref2458
feature: FragmentFeature180
cellular location: intracellular
comment: Reactome DB_ID: 4230705
display name: PARS2

Evidence348
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16358214
xref: http://identifiers.org/pubmed/11880379
comment: SLC34A3 is almost exclusively expressed in the kidney and encodes the Na+/Pi cotransporter NaPi-IIc (Segawa H et al, 2002). The protein is located at apical membranes of proximal tubules. It cotransports two Na+ ions with every Pi (electroneutral transport). Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (Bergwitz C et al, 2006)

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99178
data source: Reactome
name: Seryl-tRNA synthetase 2
name: P99178
xref: UnificationXref2471
feature: FragmentFeature181
cellular location: intracellular
comment: Reactome DB_ID: 4230747
display name: SARS2

Evidence345
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15522866
comment: NHE9 (SLC9A9) (Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the late endosome membrane.

Evidence346
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15522866
xref: http://identifiers.org/pubmed/11279194
xref: http://identifiers.org/pubmed/12845533
comment: The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.

Evidence343
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15522866
xref: http://identifiers.org/pubmed/11940519
comment: NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.

P67513
type: Protein
entity reference: P67513
data source: Reactome
xref: UnificationXref2407
cellular location: intracellular
comment: Reactome DB_ID: 4230710

Evidence344
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15522866
xref: http://identifiers.org/pubmed/11279194
comment: NHE7 and 8 (SLC9A7,8) (Nakamura N et al, 2005) are expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the trans-golgi network.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67610
data source: Reactome
name: Lysyl-tRNA synthetase
name: P67610
xref: UnificationXref2420
feature: FragmentFeature178
cellular location: intracellular
comment: Reactome DB_ID: 4230741
display name: KARS

Evidence353
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8101838
xref: http://identifiers.org/pubmed/8340364
xref: http://identifiers.org/pubmed/8910405
comment: SLC1A4, associated with the plasma membrane, mediates the exchange of cysteine and an extracellular sodium ion for a cytosolic sodium ion and any one of the four amino acids alanine, serine, threonine, or cysteine (Zerangue and Kavanaugh 1996).

Evidence352
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8101838
xref: http://identifiers.org/pubmed/8340364
xref: http://identifiers.org/pubmed/8910405
comment: SLC1A4, associated with the plasma membrane, mediates the exchange of alanine and an extracellular sodium ion for a cytosolic sodium ion and any one of the four amino acids alanine, serine, threonine, or cysteine (Zerangue and Kavanaugh 1996).

Evidence351
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12759754
xref: http://identifiers.org/pubmed/17581921
xref: http://identifiers.org/pubmed/12750889
comment: Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (from the Na+-K+-ATPase) to drive phosphate influx into cells (Virkki LV et al, 2007).

Evidence350
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10516278
xref: http://identifiers.org/pubmed/2078500
xref: http://identifiers.org/pubmed/8302848
comment: There are two transporters of this type; The genes SLC20A1 and SLC20A2 encode for PiT1 (phosphate transporter 1) and PiT2 respectively. They both have a broad tissue distribution and may play a general housekeeping role in phosphate transport such as absorbing phosphate from interstitial fluid and in extracellular matrix and cartilage calcification as well as in vascular calcification. These proteins were originally described as retroviral receptors for the gibbin ape leukemia virus receptor 1 (GLVR1, now called PiT1) (O'Hara B et al, 1990) and GLVR2 (now called PiT2) (van Zeijl M et al, 1994). However, they were found to possess Na+-coupled phosphate cotransporter function (Fernandes I et al, 1999). The transport is electrogenic with a stoichiometry of 2:1 (Na+:Pi).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A537
data source: Reactome
name: Q7A537
name: Tyrosyl-tRNA synthetase 2
xref: UnificationXref2497
feature: FragmentFeature183
cellular location: intracellular
comment: Reactome DB_ID: 4230694
display name: YARS2

P67593
type: Protein
entity reference: P67593
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Tryptophanyl-tRNA synthetase 2
xref: UnificationXref2485
feature: FragmentFeature182
cellular location: intracellular
comment: Reactome DB_ID: 4230725
display name: WARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 1
name: SL9A1_HUMAN
name: Q7A3Q7
name: SLC9A1
xref: UnificationXref2510
feature: FragmentFeature184
cellular location: plasma membrane
comment: Reactome DB_ID: 4230797
display name: NHE1

Homologues of SLC9A1
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2513
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230799

http://identifiers.org/pubmed/2363689
type: PublicationXref
id: 2363689
author: Purdue, PE
author: Kaneko, N
author: Danpure, CJ
author: Esumi, H
author: Takada, Y
db: Pubmed
title: Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon
source: Biochem J 268:517-20
year: 1990

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 3
name: SL9A3_HUMAN
name: Q7A3Q7
xref: UnificationXref2517
feature: FragmentFeature188
cellular location: plasma membrane
comment: Reactome DB_ID: 4230803
display name: SLC9A3

Evidence336
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10764807
comment: SARS2 (mitochondrial seryl tRNA synthetase) catalyzes the reaction of serine, mitochondrial tRNA(Ser), and ATP to form Ser-tRNA(Ser), AMP, and pyrophosphate. SARS2 is a class II tRNA synthetase inferred from the biochemical properties of its bovine homologue to function as a dimer (Yokogawa et al. 2000).

http://identifiers.org/pubmed/11068039
type: PublicationXref
id: 11068039
author: Okuda, T
author: Haga, T
db: Pubmed
title: Functional characterization of the human high-affinity choline transporter
source: FEBS Lett 484:92-7
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Sodium/hydrogen exchanger 3
name: Q7A721
name: SL9A3_HUMAN
xref: UnificationXref2518
feature: FragmentFeature189
cellular location: plasma membrane
comment: Reactome DB_ID: 4230804
display name: SLC9A3

Evidence337
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10828066
comment: WARS2 (mitochondrial tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, mitochondrial tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Jorgensen et al. 2000).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Q7A721
name: Sodium/hydrogen exchanger 2
name: SL9A2_HUMAN
xref: UnificationXref2515
feature: FragmentFeature187
cellular location: plasma membrane
comment: Reactome DB_ID: 4230801
display name: SLC9A2

Evidence338
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15779907
comment: YARS2 (mitochondrial tyrosyl tRNA synthetase) catalyzes the reaction of tyrosine, mitochondrial tRNA(Tyr), and ATP to form Tyr-tRNA(Tyr), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bonnefond et al. 2005).

Homologues of SLC9A3
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2519
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230805

Evidence339
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11121736
comment: Mitochondrial tRNA synthetases act in the mitochondrial matrix to catalyze the reactions of tRNAs encoded in the mitochondrial genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate (Schneider et al. 2000). The synthetase enzymes that catalyze these reactions are all encoded in the nuclear genome. In three cases, glycine, lysine, and glutamine, a single gene encodes two enzyme isoforms, one cytosolic and one mitochondrial. All other mitochondrial tRNA synthetases are encoded by genes different from the ones encoding the corresponding cytosolic enzymes.

diacylglycerols
type: SmallMoleculeReference
name: diacylglycerols [ChEBI:18035]
xref: UnificationXref355

Homologues of SLC9A2
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2516
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230802

Evidence332
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9278442
comment: KARS (mitochondrial lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 2
name: SL9A2_HUMAN
name: Q7A3Q7
xref: UnificationXref2514
feature: FragmentFeature186
cellular location: plasma membrane
comment: Reactome DB_ID: 4230800
display name: SLC9A2

Evidence333
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15274629
comment: MARS2 (mitochondrial methionyl tRNA synthetase) catalyzes the reaction of methionine, mitochondrial tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Spencer et al. 2004).

Evidence334
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10329163
comment: FARS2 (mitochondrial phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, mitochondrial tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Bullard et al. 1999).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Sodium/hydrogen exchanger 1
name: Q7A721
name: SL9A1_HUMAN
name: SLC9A1
xref: UnificationXref2512
feature: FragmentFeature185
cellular location: plasma membrane
comment: Reactome DB_ID: 4230798
display name: NHE1

Evidence335
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15779907
comment: PARS2 (mitochondrial prolyl tRNA synthetase) catalyzes the reaction of proline, mitochondrial tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The PARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).

Evidence340
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/5324173
xref: http://identifiers.org/pubmed/18682559
xref: http://identifiers.org/pubmed/18767960
xref: http://identifiers.org/pubmed/764868
xref: http://identifiers.org/pubmed/5324172
xref: http://identifiers.org/pubmed/1894595
xref: http://identifiers.org/pubmed/16125937
xref: http://identifiers.org/pubmed/182209
comment: tRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate molecule, releasing pyrophosphate. The aminoacyl adenylate remains associated with the synthetase enzyme where, in the second step it reacts with tRNA to form aminoacyl tRNA and AMP. The rapid hydrolysis of pyrophosphate makes these reactions essentially irreversible under physiological conditions (Fersht and Kaethner 1976a). Specificity of the tRNA charging reactions is achieved both by specific recognition of amino acid and tRNA substrates by the synthetase, and by an editing process in which incorrect aminoacyl adenylate molecules (e.g., valyl adenylate associated with isoleucyl tRNA synthetase) are hydrolyzed rather than conjugated to tRNAs in the second step of the reaction (Baldwin and Berg 1966a,b; Fersht and Kaethner 1976b). The tRNA synthetases can be divided into two structural classes based on conserved amino acid sequence features (Burnbaum and Schimmel 1991). A single synthetase mediates the charging of all of the tRNA species specific for any one amino acid but, with three exceptions, glycine, lysine, and glutamine, the synthetase that catalyzes aminoacylation of mitochondrial tRNAs is encoded by a different gene than the one that acts on mitochondrial tRNAs. Both mitochondrial and cytosolic tRNA synthetase enzymes are encoded by genes in the nuclear genome. A number of tRNA synthetases are known to have functions distinct from tRNA charging (reviewed by Park et al. 2005). Additionally, mutations in several of the tRNA synthetases, often affecting protein domains that are dispensable in vitro for aminoacyl tRNA synthesis, are associated with a diverse array of neurological and other diseases (Antonellis and Green 2008; Park et al. 2008). These findings raise interest into the role of these enzymes in human development and disease.

Evidence342
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2536298
xref: http://identifiers.org/pubmed/10444453
xref: http://identifiers.org/pubmed/7631746
xref: http://identifiers.org/pubmed/9933641
comment: NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.

Evidence341
type: Evidence
evidence code: inferred from electronic annotation
comment: Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are some aspects of microRNA generation and function. Aspects of mRNA synthesis annotated here include the assembly of transcription factor complexes and their role in targeting specific genes for transcription, PolII-mediated transcription (RNA synthesis) itself, and the co- and post-translational processing of this RNA, via capping, splicing, and 3'-cleavage and polyadenylation to yield mature mRNA molecules that are exported from the nucleus. mRNA editing and nonsense-mediated decay are also annotated. Processes leading to mRNA breakdown are described: deadenylation-dependent mRNA decay, microRNA-mediated RNA cleavage, and regulation of mRNA stability by proteins that bind AU-rich elements. Other pathways included here are tRNA aminoacylation and snRNP assembly.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Sodium/hydrogen exchanger 4
name: Q7A721
name: SL9A4_HUMAN
xref: UnificationXref2521
feature: FragmentFeature191
cellular location: plasma membrane
comment: Reactome DB_ID: 4230807
display name: SLC9A4

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 4
name: SL9A4_HUMAN
name: Q7A3Q7
xref: UnificationXref2520
feature: FragmentFeature190
cellular location: plasma membrane
comment: Reactome DB_ID: 4230806
display name: SLC9A4

Homologues of SLC9A4
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2522
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230808

http://identifiers.org/pubmed/16460286
type: PublicationXref
id: 16460286
author: Clapham, David E
author: Ramsey, I Scott
author: Delling, Markus
db: Pubmed
title: An introduction to TRP channels
source: Annu. Rev. Physiol. 68:619-47
year: 2006

Glycerophospholipid biosynthesis
type: Pathway
data source: Reactome
pathway component: Synthesis of PC
pathway component: Synthesis of PE
evidence: Evidence69
xref: RelationshipXref79
xref: UnificationXref531
xref: UnificationXref532
pathway order: PathwayStep62
pathway order: PathwayStep65
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence329
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12690580
comment: GARS (mitochondrial glycyl tRNA synthetase) catalyzes the reaction of glycine, tRNA(Gly), and ATP to form Gly-tRNA(Gly), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a dimer. Cytosolic and mitochondrial glycyl tRNA synthetase enzymes are both encoded by the same gene; the cytosolic protein lacks an aminoterminal 54-residue sequence found in the mitochondrial protein. Mutations in GARS are associated with Charcot-Marie-Tooth disease (Antonellis et al. 2007).

4-Aminosalicylate
type: SmallMoleculeReference
name: 4-Aminosalicylic acid
name: 4-Aminosalicylate [ChEBI:1789]
xref: UnificationXref2124

Homologues of SLC9A5
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2525
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230811

Evidence323
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref583
comment: The human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication among this astronomical number of elements. This communication occurs across synapses, the functional connection between neurons. Synapses can be divided into two general classes: electrical synapses and chemical synapses. Electrical synapses permit direct, passive flow of electrical current from one neuron to another. The current flows through gap junctions, specialized membrane channels that connect the two cells. Chemical synapses enable cell-to-cell communication using neurotransmitter release. Neurotransmitters are chemical agents released by presynaptic neurons that trigger a secondary current flow in postsynaptic neurons by activating specific receptor molecules. Neurotransmitter secretion is triggered by the influx of Ca2+ through voltage-gated channels, which gives rise to a transient increase in Ca2+ concentration within the presynaptic terminal. The rise in Ca2+ concentration causes synaptic vesicles (the presynaptic organelles that store neurotransmitters) to fuse with the presynaptic plasma membrane and release their contents into the space between the pre- and postsynaptic cells.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 5
name: SL9A5_HUMAN
name: Q7A3Q7
xref: UnificationXref2523
feature: FragmentFeature192
cellular location: plasma membrane
comment: Reactome DB_ID: 4230809
display name: SLC9A5

Evidence324
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12690580
comment: GARS (cytosolic glycyl tRNA synthetase) catalyzes the reaction of glycine, tRNA(Gly), and ATP to form Gly tRNA(Gly), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a dimer. Cytosolic and mitochondrial glycyl tRNA synthetase enzymes are both encoded by the same gene; the cytosolic protein lacks an aminoterminal 54 residue sequence found in the mitochondrial protein. Mutations in GARS are associated with Charcot Marie Tooth disease and distal spinal muscular atrophy, two diseases characterized by axonal dysfunction (Antonellis et al. 2006)

UnificationXref790
type: UnificationXref
id: 4231259
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231259

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Sodium/hydrogen exchanger 5
name: Q7A721
name: SL9A5_HUMAN
xref: UnificationXref2524
feature: FragmentFeature193
cellular location: plasma membrane
comment: Reactome DB_ID: 4230810
display name: SLC9A5

Evidence321
type: Evidence
evidence code: inferred from electronic annotation
comment: Neuotransmitter uptake by astrocytes is mediated by specific transporter located on the astrocytic membrane. The imported neurotransmitter in the astrocytes is metabolized and transported back to the neuron via specialized transporters.

UnificationXref791
type: UnificationXref
id: REACT_105136
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105136.9

Homologues of SLC9A6
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2536
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230794

Evidence322
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref583
comment: Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell.

UnificationXref792
type: UnificationXref
id: 113521
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 6
name: SL9A6_HUMAN
name: Q7A3Q7
xref: UnificationXref2534
feature: FragmentFeature194
cellular location: intracellular
comment: Reactome DB_ID: 4230792
display name: SLC9A6

Evidence327
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17384640
xref: http://identifiers.org/pubmed/15779907
comment: DARS2 (mitochondrial aspartyl tRNA synthetase) catalyzes the reaction of aspartate, mitochondrial tRNA(Asp), and ATP to form Asp tRNA(Asp), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer (Bonnefond et al. 2005). Homozygosity for DARS2 mutations is associated with leukoencephalopathy with brainstem and spinal cord involvement plus lactate elevation (Scheper et al 2007).

UnificationXref793
type: UnificationXref
id: REACT_3290
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3290.1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Sodium/hydrogen exchanger 6
name: SL9A6_HUMAN
name: Q7A721
xref: UnificationXref2535
feature: FragmentFeature195
cellular location: intracellular
comment: Reactome DB_ID: 4230793
display name: SLC9A6

Evidence328
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15779907
comment: EARS2 (mitochondrial glutamyl tRNA synthetase) catalyzes the reaction of glutamate, mitochondrial tRNA(Glu), and ATP to form Glu-tRNA(Glu), AMP, and pyrophosphate. The EARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).

UnificationXref794
type: UnificationXref
id: 29654
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29654

http://identifiers.org/pubmed/16011460
type: PublicationXref
id: 16011460
author: Harrison, EH
db: Pubmed
title: Mechanisms of digestion and absorption of dietary vitamin A
source: Annu Rev Nutr 25:87-103
year: 2005

Homologues of SLC9A7
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2546
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230817

Evidence325
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9878398
xref: http://identifiers.org/pubmed/16169847
xref: http://identifiers.org/pubmed/14500886
comment: Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes (Quevillon et al. 1999; Wolfe et al. 2003, 2005).

UnificationXref795
type: UnificationXref
id: REACT_4667
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4667.2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Sodium/hydrogen exchanger 7
name: Q7A3Q7
name: SL9A7_HUMAN
xref: UnificationXref2544
feature: FragmentFeature196
cellular location: intracellular
comment: Reactome DB_ID: 4230815
display name: SLC9A7

Evidence326
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15779907
comment: NARS2 (mitochondrial asparaginyl tRNA synthetase) catalyzes the reaction of asparagine, mitochondrial tRNA(Asn), and ATP to form Asn-tRNA(Asn), AMP, and pyrophosphate. The NARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).

UnificationXref796
type: UnificationXref
id: Q7A561
db: UniProt

Homologues of SLC9A8(1-577)
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2549
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230820

UnificationXref798
type: UnificationXref
id: 4229956
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229956

1-thioglycine
type: SequenceModificationVocabulary
xref: UnificationXref1574

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: Sodium/hydrogen exchanger 7
name: Q7A721
name: SL9A7_HUMAN
xref: UnificationXref2545
feature: FragmentFeature197
cellular location: intracellular
comment: Reactome DB_ID: 4230816
display name: SLC9A7

UnificationXref797
type: UnificationXref
id: 4229955
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229955

UnificationXref799
type: UnificationXref
id: 4229958
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229958

Evidence331
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10684970
comment: LARS2 (mitochondrial leucyl tRNA synthetase) catalyzes the reaction of leucine, mitochondrial tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Bullard et al. 2000).

Evidence330
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9466989
comment: IARS2 (mitochondrial isoleucyl tRNA synthetase) catalyzes the reaction of isoleucine, mitochondrial tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Degoul et al. 1995).

Synthesis of UDP-N-acetyl-glucosamine
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction260
pathway component: BiochemicalReaction259
evidence: Evidence421
xref: RelationshipXref492
xref: UnificationXref2986
xref: UnificationXref2987
pathway order: PathwayStep409
pathway order: PathwayStep410
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence318
type: Evidence
evidence code: inferred from electronic annotation
comment: Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter. This topic will be annotated in a future release.

L-Glutamine
type: SmallMoleculeReference
name: L-Glutamine [ChEBI:18050]
name: L-2-Aminoglutaramic acid
xref: UnificationXref904

Evidence319
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14730707
comment: Excess L-Glutamate released by the pre-synaptic neuron in the synaptic cleft is cleared by high affinity transporters called the excitatory amino acid transporters (EAATs) to terminate synaptic actions of the neurotransmitter and to recycle these molecules. Five types of EAATs have been identified EAAT1-EAAT5 in the mammalian CNS. EAAT1 and EAAT2 are mainly expressed by astrocytes whereas EAAT3 and EAAT4 are predominantly neuronal. EAAT3 are expressed throughout the CNS however, EAAT4 is predominantly localized to purkinje cells. EAAT5 are expressed rod photoreceptor and bipolar cells of retina. Astrocytic EAATs are expressed in astrocytes in close apposition to the synapses and neuronal EAATs are expressed in the extra-synaptic or peri-synaptic locations on the neurons. Astrocytic EAATs are responsible for majority of the glutamate uptake, neuronal transporters are responsible for glutamate clearance in specialized synapses in cerebellum where the spatial relationship between the glutamate receptors and EAATs is altered and glutamate receptors are expressed in the peri-synaptic region.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: SLC9A8(1-577)
name: Sodium/hydrogen exchanger 8
name: SL9A8_HUMAN
name: Q7A3Q7
xref: UnificationXref2547
feature: FragmentFeature198
cellular location: intracellular
comment: Reactome DB_ID: 4230818
display name: SLC9A8

Iron uptake and transport
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction235
evidence: Evidence409
xref: UnificationXref2916
xref: RelationshipXref477
xref: UnificationXref2915
pathway order: PathwayStep370
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Sodium/hydrogen exchanger 9
type: Protein
entity reference: Q7A3Q7
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: SL9A9_HUMAN
name: Q7A3Q7
xref: UnificationXref2558
feature: FragmentFeature200
cellular location: intracellular
comment: Reactome DB_ID: 4230785
display name: SLC9A9

Evidence310
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20301677
xref: http://identifiers.org/pubmed/15606768
xref: http://identifiers.org/pubmed/1583868
xref: http://identifiers.org/pubmed/8892014
xref: http://identifiers.org/pubmed/2116554
xref: http://identifiers.org/pubmed/17356132
comment: Phenylalanine hydroxylase (PAH) catalyzes the conversion of phenylalanine to tyrosine. In the absence of functional PAH, phenylalanine accumulates to high levels in the blood (Mitchell and Scriver 2010) and is converted to phenylpyruvate and phenyllactate (Clemens et al. 1990; Langenbeck et al. 1992). The extent of these conversions is modulated by genetic factors distinct from PAH, as siblings with the identical PAH defect can produce different amounts of them (Treacy et al. 1996). Both L-amino acid oxidase (Boulland et al. 2004) and Kynurenine--oxoglutarate transaminase 3 (Han et al. 2004) can catalyze the conversion of phenylalanine to phenylpyruvate and lactate dehydrogenase can catalyze the conversion of the latter molecule to phenyllactate (Meister 1951). Elevated levels of phenylalanine, phenylpyruvate, and phenyllactate are all thought to contribute to the symptoms of phenylketonuria. One possible target is the metabolism of kynurenine.

UnificationXref780
type: UnificationXref
id: 4229826
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229826

Sodium/hydrogen exchanger 9
type: Protein
entity reference: Q7A721
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7A721
name: SL9A9_HUMAN
xref: UnificationXref2559
feature: FragmentFeature201
cellular location: intracellular
comment: Reactome DB_ID: 4230788
display name: SLC9A9

Evidence311
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16968212
xref: http://identifiers.org/pubmed/21377628
xref: http://identifiers.org/pubmed/18632300
xref: http://identifiers.org/pubmed/20435355
comment: The process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defects in the genes involved in the retinoid cycle cause degenerative retinal diseases. These defective genes are described here (for reviews see Travis et al. 2007, Palczewski 2010, Fletcher et al. 2011, den Hollander et al. 2008).

UnificationXref781
type: UnificationXref
id: 4229827
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229827

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A721
data source: Reactome
name: SLC9A8(1-577)
name: Sodium/hydrogen exchanger 8
name: Q7A721
name: SL9A8_HUMAN
xref: UnificationXref2548
feature: FragmentFeature199
cellular location: intracellular
comment: Reactome DB_ID: 4230819
display name: SLC9A8

Evidence312
type: Evidence
evidence code: inferred from electronic annotation
comment: Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally normal human proteins. The first group encompasses the infectious diseases such as influenza, tuberculosis and HIV infection. The second group involves human proteins modified either by a mutation or by an abnormal post-translational event that produces an aberrant protein with a novel function. Examples include somatic mutations of EGFR and FGFR (epidermal and fibroblast growth factor receptor) genes, which encode constitutively active receptors that signal even in the absence of their ligands, or the somatic mutation of IDH1 (isocitrate dehydrogenase 1) that leads to an enzyme active on 2-oxoglutarate rather than isocitrate, or the abnormal protein aggregations of amyloidosis which lead to diseases such as Alzheimer's. Infectious diseases are represented in Reactome as microbial-human protein interactions and the consequent events. The existence of variant proteins and their association with disease-specific biological processes is represented by inclusion of the modified protein in a new or variant reaction, an extension to the 'normal' pathway. Diseases which result from proteins performing their normal functions but at abnormal rates can also be captured, though less directly. Many mutant alleles encode proteins that retain their normal functions but have abnormal stabilities or catalytic efficiencies, leading to normal reactions that proceed to abnormal extents. The phenotypes of such diseases can be revealed when pathway annotations are combined with expression or rate data from other sources.

Homologues of SLC9A9
type: Protein
data source: Reactome
member physical entity: Sodium/hydrogen exchanger 9
xref: UnificationXref2560
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230789

Evidence313
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16212990
comment: Excess L-Glutamate released by the pre-synaptic neuron in the synaptic cleft is cleared by high affinity transporters called the excitatory amino acid transporters (EAATs) to terminate synaptic actions of the neurotransmitter and to recycle these molecules. Five types of EAATs have been identified EAAT1-EAAT5 in the mammalian CNS. EAAT1 and EAAT2 are mainly expressed by astrocytes whereas EAAT3 and EAAT4 are predominantly neuronal. EAAT3 are expressed throughout the CNS however, EAAT4 is predominantly localized to purkinje cells. EAAT5 are expressed rod photoreceptor and bipolar cells of retina. Astrocytic EAATs are expressed in astrocytes in close apposition to the synapses and neuronal EAATs are expressed in the extra-synaptic or peri-synaptic locations on the neurons. Astrocytic EAATs are responsible for majority of the glutamate uptake, neuronal transporters are responsible for glutamate clearance in specialized synapses in cerebellum where the spatial relationship between the glutamate receptors and EAATs is altered and glutamate receptors are expressed in the peri-synaptic region.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A879
data source: Reactome
name: Sodium-dependent phosphate transport protein 2B
name: NPT2B_HUMAN
name: SLC34A2
xref: UnificationXref2567
feature: FragmentFeature203
cellular location: plasma membrane
comment: Reactome DB_ID: 4230841
display name: Q7A879

Evidence314
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8825650
xref: http://identifiers.org/pubmed/9701566
xref: http://identifiers.org/pubmed/16704978
xref: http://identifiers.org/pubmed/16990140
xref: http://identifiers.org/pubmed/10440375
xref: http://identifiers.org/pubmed/17478680
xref: http://identifiers.org/pubmed/11001057
comment: Communication at the synapse involves the release of glutamate from the presynaptic neuron and its binding to glutamate receptors on the postsynaptic cell to generate a series of events that lead to propagation of the synaptic transmission. This process begins with the formation of synaptic vesicles in the presynaptic neuron, proceeds to the loading of glutamate into the vesicles, and concludes with the release of glutamate into the synaptic cleft. The glutamate life cycle in the neuron begins with the loading of the nascent synaptic vesicles with cytosolic glutamate with the help the transporter protein, VGLUT1, located in the synaptic vesicular membrane. Glutamate loaded vesicles are formed in the cytoplasm and then transported to a site close to the plasma membrane where the vesicle is docked with the help of several proteins. One of the key players in the docking process in Munc 18, which interacts with syntaxin (in the plasma membrane), MINT (Munc18 interacting molecule), and DOC2. These interactions along with the secondary interactions are needed for docking the synaptic vesicle to the plasma membrane. The docked synaptic vesicle is not ready for release until it undergoes molecular changes to prime it for fusion with the plasma membrane. Munc13 is one of the main players in the priming process. Munc 13 interacts with RIM (Rab3A interacting molecule) located in the synaptic vesicle. Munc 13 also interacts with DOC2. The precise molecular mechanisms of the interactions that result in docking versus priming are not clear and the docking and priming process have been combined in this annotation of this pathway. Once primed the synaptic vesicle is ready for release. Synaptic transmission involves an action potential that is generated in the presynaptic cell which induces the opening of voltage gated Ca2+ channels (VGCC) located in the plasma membrane of the presynaptic neuron. Typically N, P/Q and R type of VGCCs are involved in the neurotransmitter release. Ca2+…

UnificationXref784
type: UnificationXref
id: 4229830
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229830

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A879
data source: Reactome
name: Sodium-dependent phosphate transport protein 2C
name: NPT2C_HUMAN
name: SLC34A3
xref: UnificationXref2571
feature: FragmentFeature204
cellular location: plasma membrane
comment: Reactome DB_ID: 4230837
display name: Q7A879

Evidence315
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11068039
comment: Choline transporter symports Na ion and Choline from the extracellular region into the cytosol. The choline transporters are located in the nerve terminals of cholinergic neurons.

UnificationXref785
type: UnificationXref
id: 4229831
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229831

http://identifiers.org/pubmed/7678419
type: PublicationXref
id: 7678419
author: Smith, BL
author: Agre, P
author: Knepper, MA
author: Christensen, EI
author: Nielsen, S
db: Pubmed
title: CHIP28 water channels are localized in constitutively water-permeable segments of the nephron
source: J Cell Biol 120:371-83
year: 1993

Electrogenic Na+/Pi cotransporters
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2568
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230842

Evidence316
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18029057
comment: Acetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then release of acetylcholine. This cycle occurs in neurons of central nervous system (CNS), peripheral, autonomic and somatic nervous system. In the CNS, the acetylcholine is released by the presynaptic neurons into the synaptic cleft where the released acetylcholine is accessible to acetylcholine receptors located on the postsynaptic neurons.

UnificationXref782
type: UnificationXref
id: 4229828
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229828

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A879
data source: Reactome
name: Sodium-dependent phosphate transport protein 2A
name: SLC34A1
name: NPT2A_HUMAN
xref: UnificationXref2566
feature: FragmentFeature202
cellular location: plasma membrane
comment: Reactome DB_ID: 4230840
display name: Q7A879

Evidence317
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15217342
xref: http://identifiers.org/pubmed/16819626
xref: http://identifiers.org/pubmed/16865347
xref: http://identifiers.org/pubmed/17880890
comment: Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described.

UnificationXref783
type: UnificationXref
id: 4229829
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229829

UnificationXref789
type: UnificationXref
id: REACT_97518
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97518.9

UnificationXref788
type: UnificationXref
id: 4229833
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229833

UnificationXref787
type: UnificationXref
id: REACT_109914
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_109914.9

Type III Na+/Pi cotransporters
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2579
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230832

UnificationXref786
type: UnificationXref
id: 4230077
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230077

http://identifiers.org/pubmed/9693067
type: PublicationXref
id: 9693067
author: Bader, B
author: Löffler, M
author: Fries, M
author: Knecht, W
db: Pubmed
title: Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
source: Protein Expr Purif 13:414-22
year: 1998

Evidence320
type: Evidence
evidence code: inferred from electronic annotation
comment: In astrocytic glutamate-glutamine cycle, the excess glutamate released by the pre-synaptic neuron in the synaptic cleft is transported into the astrocyte by a family glutamate transporters called the excitatory amino acid transporters 1 and 2, EAAT1 and EAAT2. Astrocytes carrying these transporters exist in close apposition to the synapse to clear excess glutamate to prevent excessive activation of neurons and hence neuronal death. Glutamate in astrocytes is converted to glutamine by glutamine synthetase. Glutamine is then transported into the extracellular space by system N transporters. The glutamate in the extracellular space is available for neuronal uptake.

UniProt:P63740
type: ProteinReference
xref: UnificationXref1123
organism: BioSource1

http://identifiers.org/pubmed/9829975
type: PublicationXref
id: 9829975
author: Klaerke, DA
author: Zeuthen, T
author: Meinild, AK
db: Pubmed
title: Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5
source: J Biol Chem 273:32446-51
year: 1998

Excitatory amino acid transporters
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2664
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230845
display name: EAATs

Evidence306
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7980580
xref: http://identifiers.org/pubmed/8537108
comment: Natural resistance-associated macrophage proteins (NRAMPs) regulates macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating metal ion transport across macrophage membranes and the subsequent use of these ions in the control of free radical formation. The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes.

UnificationXref772
type: UnificationXref
id: P99119
db: UniProt

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3A6
data source: Reactome
name: Q7A3A6
name: SLC7A3
name: Cationic amino acid transporter 3
xref: UnificationXref2646
feature: FragmentFeature211
cellular location: plasma membrane
comment: Reactome DB_ID: 4230674
display name: CAT-3

Evidence305
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19379690
xref: http://identifiers.org/pubmed/19648010
xref: http://identifiers.org/pubmed/17496910
xref: http://identifiers.org/pubmed/19619488
xref: http://identifiers.org/pubmed/19536106
xref: http://identifiers.org/pubmed/18043707
xref: http://identifiers.org/pubmed/11742412
xref: http://identifiers.org/pubmed/19935667
xref: http://identifiers.org/pubmed/15450248
xref: http://identifiers.org/pubmed/19762341
xref: http://identifiers.org/pubmed/19458711
xref: http://identifiers.org/pubmed/15520807
xref: http://identifiers.org/pubmed/16939974
xref: http://identifiers.org/pubmed/16260143
xref: http://identifiers.org/pubmed/21252999
xref: http://identifiers.org/pubmed/15863030
xref: http://identifiers.org/pubmed/17604717
xref: http://identifiers.org/pubmed/17084981
xref: http://identifiers.org/pubmed/18483217
xref: http://identifiers.org/pubmed/21781017
comment: Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellular environment by activating downstream signaling cascades. Depending on the cellular context, this may impact cellular proliferation, differentiation, and survival. On the organism level, signal transduction regulates overall growth and behavior. Receptor tyrosine kinases (RTKs) transmit extracellular signals by phosphorylating their protein partners on conserved tyrosine residues. Some of the best studied RTKs are EGFR (reviewed in Avraham and Yarden, 2011), FGFR (reviewed in Eswarakumar et al, 2005), insulin receptor (reviewed in Saltiel and Kahn, 2001), NGF (reviewed in Reichardt, 2006), PDGF (reviewed in Andrae et al, 2008) and VEGF (reviewed in Xie et al, 2004). RTKs frequently activate downstream signaling through RAF/MAP kinases (reviewed in McKay and Morrison, 2007 and Wellbrock et al 2004), AKT (reviewed in Manning and Cantley, 2007) and PLC- gamma (reviewed in Patterson et al), which ultimately results in changes in gene expression and cellular metabolism. Receptor serine/threonine kinases of the TGF-beta family, such as TGF-beta receptors (reviewed in Kang et al. 2009) and BMP receptors (reviewed in Miyazono et al. 2009), transmit extracellular signals by phosphorylating regulatory SMAD proteins on conserved serine and threonine residues. This leads to formation of complexes of regulatory SMADs and SMAD4, which translocate to the nucleus where they act as transcription factors. WNT receptors transmit their signal through beta-catenin. In the absence of ligand, beta-catenin is constitutively degraded in a ubiquitin-dependent manner. WNT receptor stimulation…

UnificationXref771
type: UnificationXref
id: REACT_4026
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4026.2

SLC17A7
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: VGLU1_HUMAN
name: Vesicular glutamate transporter 1
xref: UnificationXref2673
feature: FragmentFeature212
cellular location: intracellular
comment: Reactome DB_ID: 4230850
display name: Q7A3I9

Evidence304
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11340090
xref: http://identifiers.org/pubmed/16688755
xref: http://identifiers.org/pubmed/16011460
xref: http://identifiers.org/pubmed/22074928
xref: http://identifiers.org/pubmed/21350678
xref: http://identifiers.org/pubmed/20430952
xref: http://identifiers.org/pubmed/22658984
xref: http://identifiers.org/pubmed/22074927
xref: http://identifiers.org/pubmed/20188572
xref: http://identifiers.org/pubmed/8382952
xref: http://identifiers.org/pubmed/21111842
xref: http://identifiers.org/pubmed/15384919
comment: Visual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are photochemical, biochemical and electrophysiological and are highly conserved across many species. This process occurs in two types of photoreceptors in the retina, rods and cones. Each type consists of two parts, the outer segment which detects a photon signal and the inner segment which contains the necessary machinery for cell metabolism. Each type of cell functions differently. Rods are very light sensitive but their flash response is slow so they work best in twilight conditions but are not good at detecting objects moving quickly. Cones are less light-sensitive and have a fast flash response so they work best in daylight conditions and are better at detecting fast moving objects than rods. The visual pigment consists of a chromophore (11-cis-retinal, 11cRAL, A1) covalently attached to a GPCR opsin family member. The linkage is via a Schiff base forming retinylidene protein. Upon photon absorption, 11cRAL isomerises to all-trans retinal (atRAL), changing the conformation of opsin to an activated form which can activate the regulatory G protein transducin (Gt). The alpha subunit of Gt activates phosphodiesterase which hydrolyses cGMP to 5'-GMP. As high level of cGMP keep cGMP-gated sodium channels open, the lowering of cGMP levels closes these channels which causes hyperpolarization of the cell and subsequently, closure of voltage-gated calcium channels. As calcium levels drop, the level of the neurotransmitter glutamate also drops causing depolarization of the cell. This effectively relays the light signal to postsynaptic neurons as electrical signal (Burns & Pugh 2010, Korenbrot 2012, Pugh & Lamb 1993). 11cRAL cannot be synthesised in vertebrates. Vitamin A from many dietary sources is the precursor for 11cRAL. It is taken from food in the form of esters such as reti…

UnificationXref774
type: UnificationXref
id: P65256
db: UniProt

VGLUTs
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Vesicular glutamate transporter 3
member physical entity: SLC17A7
xref: UnificationXref2676
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230853

Evidence303
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/22074928
xref: http://identifiers.org/pubmed/22074927
xref: http://identifiers.org/pubmed/21111842
xref: http://identifiers.org/pubmed/15384919
comment: Rods and cones share the same mechanism for the phototransduction process but perform functionally different roles. Although cone photoreceptors make up around 5% of all photoreceptor cells and are outnumbered 20 to 1 by rod photoreceptors, they mediate daylight vision in the human eye whereas rods mediate twilight vision. Also, cones are around 100-times less light-sensitive than rods thereby depriving us of colour vision in dark conditions in which cones cannot function. Rod function saturates in even moderate amounts of light whereas cones can adjust to even very bright light conditions, a process called light adaptation. In bright conditions, rods can take up to one hour to regain their sensitivity whereas cones can recover in a few minutes, a process called dark adaptation and which allows us to retain visual perception in changing light conditions. Cone cells express three types of opsin which allow colour discrimination. Long Wavelength Sensitive Opsin (OPN1LW) detects red , Short Wavelength Sensitive Opsin (OPN1SW) detects blue, and Short Wavelength Sensitive Opsin (OPN1SW) detects green regions of the light spectrum. In the canonical retinoid (visual) cycle, the visual chromophore is regenerated in reactions involving the rod outer segments (ROS) and the retinal pigment epithelium (RPE). For cones, chromophore recycling is independent of the RPE and instead involves Muller cells in the retina which supply the chromophore selectively to cones. The molecular steps of the cone retinoid (visual) cycle are outlined in this section. The ability of cones to react to bright and differing light conditions means it has to regenerate the chromophore much quicker than rods. All-trans-retinol (atROL) released from cone outer segments is taken up by Muller cells where it is directly isomerized back to 11-cis-retinol (11cROL) then esterified by LRAT. When required, these 11-cis-retinyl esters can be hydrolysed by 11-cis-RE hydrolases back to 11cROL then oxidised in the co…

UnificationXref773
type: UnificationXref
id: 4229818
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229818

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: SLC1A5
name: Q7A7I9
xref: UnificationXref2617
feature: FragmentFeature208
cellular location: plasma membrane
comment: Reactome DB_ID: 4230658
display name: ASCT2

Evidence302
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9705317
comment: All-trans-retinal (atRAL) can diffuse across membranes to the cytosol and is reduced to all-trans-retinol (atROL) by the action of a short-chain dehydrogenase/reductase 3 using NADP+/NADPH as cofactor (Haeseleer et al. 1998).

SLC1A4
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7A7I9
xref: UnificationXref2606
feature: FragmentFeature207
cellular location: plasma membrane
comment: Reactome DB_ID: 4230652
display name: ASCT1

Evidence301
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12967557
xref: http://identifiers.org/pubmed/18710302
xref: http://identifiers.org/pubmed/19530173
xref: http://identifiers.org/pubmed/19619488
xref: http://identifiers.org/pubmed/20576942
xref: http://identifiers.org/pubmed/19204114
xref: http://identifiers.org/pubmed/17230199
xref: http://identifiers.org/pubmed/17143292
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/23256519
xref: http://identifiers.org/pubmed/19365405
xref: http://identifiers.org/pubmed/10858654
xref: http://identifiers.org/pubmed/16099039
comment: WNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Saito-Diaz et al, 2013; MacDonald et al, 2009). The pathway is named for the WNT ligands, a large family of secreted cysteine-rich glycoproteins. At least 19 WNT members have been identified in humans and mice with distinct expression patterns during development (reviewed in Willert and Nusse, 2012). These ligands can activate at least three different downstream signaling cascades depending on which receptors they engage. In the so-called 'canonical' WNT signaling pathway, WNT ligands bind one of the 10 human Frizzled (FZD) receptors in conjunction with the LRP5/6 co-receptors to activate a transcriptional cascade that controls processes such as cell fate, proliferation and self-renenwal of stem cells. Engagement of the FZD-LRP receptor by WNT ligand results in the stabilization and translocation of cytosolic beta-catenin to the nucleus where it is a co-activator for LEF (lymphoid enhancer-binding factor)- and TCF (T cell factor) -dependent transcription. In the absence of WNT ligand, cytosolic beta-catenin is phosphorylated by a degradation complex consisting of glycogen synthase kinase 3 (GSK3), casein kinase 1 (CK1), Axin and Adenomatous polyposis coli (APC), and subsequently ubiquitinated and degraded by the 26S proteasome (reviewed in Saito-Diaz et al, 2013; Kimmelman and Xu, 2006). In addition to the beta-catenin-dependent transcriptional response, WNT signaling can also activate distinct non-transcriptional pathways that regulate cell migration and polarity. These beta-catenin-independent 'non-canonical' pathways signal through Frizzled receptors independently of LRP5/6, or occur through the tyrosine kinase receptors ROR and RYK (reviewed in Veeman et al, 2003; James et al, 2009). Non-canonical WNT pathways are best studied in Drosophila where the planar cell polarit…

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3A6
data source: Reactome
name: Q7A3A6
name: Low affinity cationic amino acid transporter 2, isoform B
name: SLC7A2-1
name: SLC7A2, isoform B
xref: UnificationXref2636
feature: FragmentFeature210
cellular location: plasma membrane
comment: Reactome DB_ID: 4230671
display name: CAT-2B

Evidence300
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19837038
xref: http://identifiers.org/pubmed/17141155
xref: http://identifiers.org/pubmed/17108000
xref: http://identifiers.org/pubmed/21554866
xref: http://identifiers.org/pubmed/21768372
xref: http://identifiers.org/pubmed/22952392
xref: http://identifiers.org/pubmed/22653731
xref: http://identifiers.org/pubmed/23256519
xref: http://identifiers.org/pubmed/22796206
xref: http://identifiers.org/pubmed/21725318
xref: http://identifiers.org/pubmed/16678096
xref: http://identifiers.org/pubmed/23260141
xref: http://identifiers.org/pubmed/16678095
xref: http://identifiers.org/pubmed/22983114
comment: 19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the canonical (beta-catenin) WNT signaling cascade and several non-canonical pathways, including the planar cell polarity (PCP), the regulation of intracellular calcium signaling and activation of JNK kinases. WNT proteins exist in a gradient outside the secreting cell and are able to act over both short and long ranges to promote proliferation, changes in cell migration and polarity and tissue homeostasis, among others (reviewed in Saito-Diaz et al, 2012; Willert and Nusse, 2012). The WNTs are ~40kDa proteins with 23 conserved cysteine residues in the N-terminal that may form intramolecular disulphide bonds. They also contain an N-terminal signal sequence and a number of N-linked glycosylation sites (Janda et al, 2012). In addition to being glycosylated, WNTs are also lipid-modified in the endoplasmic reticulum by a WNT-specific O-acyl-transferase, Porcupine (PORCN), contributing to their characteristic hydrophobicity. PORCN-dependent palmitoylation is required for the secretion of WNT as well as its signaling activity, as either depletion of PORCN or mutation of the conserved serine acylation site results in the intracellular accumulation of WNT ligand (Takada et al, 2006; Barrott et al, 2011; Biechele et al, 2011; reviewed in Willert and Nusse, 2012). Secretion of WNT requires a number of other dedicated factors including the sorting receptor Wntless (WLS) (also knownas Evi, Sprinter, and GPR177), which binds WNT and escorts it to the cell surface (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006). A WNT-specific retromer containing SNX3 is subsequently required for the recycling of WLS back to the Golgi (reviewed in Herr et al, 2012; Johannes and Wunder, 2011). Once at the cell surface, WNT makes extensive contacts with components of the extracellular mat…

UnificationXref770
type: UnificationXref
id: 29708
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29708

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3A6
data source: Reactome
name: Q7A3A6
name: SLC7A1
name: High affinity cationic amino acid transporter 1
xref: UnificationXref2631
feature: FragmentFeature209
cellular location: plasma membrane
comment: Reactome DB_ID: 4230677
display name: CAT-1

UDPglucose
type: SmallMoleculeReference
name: UDP-D-glucose
name: UDPglucose [ChEBI:18066]
name: UDP-glucose
xref: UnificationXref223

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99VV7
data source: Reactome
name: S20A2_HUMAN
name: SLC20A2
name: Sodium-dependent phosphate transporter 2
xref: UnificationXref2578
feature: FragmentFeature206
cellular location: plasma membrane
comment: Reactome DB_ID: 4230831
display name: Q99VV7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99VV7
data source: Reactome
name: S20A1_HUMAN
name: SLC20A1
name: Sodium-dependent phosphate transporter 1
xref: UnificationXref2577
feature: FragmentFeature205
cellular location: plasma membrane
comment: Reactome DB_ID: 4230830
display name: Q99VV7

Evidence309
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15421980
comment: The ability of human lactate dehydrogenase to catalyze the reaction of phenylalanine with NADH + H+ to form phenyllactate and NAD+ is inferred from the properties of bovine heart lactate dehydrogenase (Meister 1951). As these studies were carried out only on the one bovine isoform, the reaction is inferred only for the corresponding human isoform. The reaction rate measured for bovine LDHB acting on phenylpyruvate is approximately 2% of its rate on pyruvate, but could yield appreciable amounts of phenyllactate under conditions of high phenylpyruvate concentration.

Evidence308
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20466922
xref: http://identifiers.org/pubmed/15608701
xref: http://identifiers.org/pubmed/21349098
xref: http://identifiers.org/pubmed/19855401
comment: Infection by Mycobacterium tuberculosis (Mtb) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. A third of the world's population is estimated to harbour latent tuberculosis. Latent infection involves the bacterium being internalized by macrophages where it stops and counters the innate immune answer (Russell 2011, Russell et al. 2010). When a status-quo is reached, Mtb enters a non-replicating persistent state (Barry et al. 2009, Boshoff & Barry 2005).

Evidence307
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19369951
comment: Alveolar macrophages normally develop their phagosome along the endolysosomal pathway. However, after having internalized Mtb, this development is arrested at an early stage and only includes acidification, nitric oxide and superoxide production, as well as the use of a few other proteins that can be gained from other endosomes which still can interact with the phagosome (Flannagan et al. 2009).

UnificationXref779
type: UnificationXref
id: 4229825
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229825

UnificationXref775
type: UnificationXref
id: 4229821
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229821

UnificationXref776
type: UnificationXref
id: 4229822
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229822

UnificationXref777
type: UnificationXref
id: 4229823
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229823

UnificationXref778
type: UnificationXref
id: 4229824
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229824

extracellular region
type: CellularLocationVocabulary
xref: UnificationXref306

UnificationXref763
type: UnificationXref
id: REACT_133714
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_133714.5

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4P8
data source: Reactome
name: Solute carrier family 13 member 3
name: Q7A4P8
name: S13A3_HUMAN
name: SLC13A3
name: Sodium/dicarboxylate co-transporter 3
xref: UnificationXref2759
feature: FragmentFeature222
cellular location: plasma membrane
comment: Reactome DB_ID: 4230897
display name: NaDC3

UnificationXref762
type: UnificationXref
id: 4231338
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231338

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4P8
data source: Reactome
name: Solute carrier family 13 member 2
name: Q7A4P8
name: SLC13A2
name: S13A2_HUMAN
name: Sodium/dicarboxylate cotransporter 1
xref: UnificationXref2756
feature: FragmentFeature221
cellular location: plasma membrane
comment: Reactome DB_ID: 4230906
display name: NaDC1

UnificationXref761
type: UnificationXref
id: REACT_144482
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_144482.5

Solute carrier family 13 member 4
type: Protein
entity reference: Q7A4P8
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium/sulphate co-transporter 2
name: Q7A4P8
name: S13A4_HUMAN
name: SLC13A4
xref: UnificationXref2742
feature: FragmentFeature220
cellular location: plasma membrane
comment: Reactome DB_ID: 4230894
display name: NaS2

UnificationXref760
type: UnificationXref
id: 4231419
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231419

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4P8
data source: Reactome
name: Sodium/sulphate cotransporter 1
name: Q7A4P8
name: S13A1_HUMAN
name: SLC13A1
name: Solute carrier family 13 member 1
xref: UnificationXref2739
feature: FragmentFeature219
cellular location: plasma membrane
comment: Reactome DB_ID: 4230903
display name: NaS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A402
data source: Reactome
name: Q7A402
name: SLC10A6
name: Solute carrier family 10 member 6
name: SOAT_HUMAN
xref: UnificationXref2730
feature: FragmentFeature218
cellular location: plasma membrane
comment: Reactome DB_ID: 4230889
display name: SOAT

Sodium-coupled monocarboxylate transporter 1
type: Protein
entity reference: Q7A7P6
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: SLC5A8
name: Q7A7P6
name: SC5A8_HUMAN
name: SMCT1
xref: UnificationXref2695
feature: FragmentFeature217
cellular location: plasma membrane
comment: Reactome DB_ID: 4230869
display name: AIT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: Sodium-dependent phosphate transport protein 1
name: SLC17A1
name: NPT1_HUMAN
xref: UnificationXref2690
feature: FragmentFeature216
cellular location: plasma membrane
comment: Reactome DB_ID: 4230862
display name: Q7A3I9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: SLC17A5
name: Q7A3I9
name: S17A5_HUMAN
xref: UnificationXref2687
feature: FragmentFeature215
cellular location: intracellular
comment: Reactome DB_ID: 4230859
display name: Sialin

dTDP
type: SmallMoleculeReference
name: Deoxythymidine 5'-diphosphate
name: dTDP [ChEBI:18075]
xref: UnificationXref1312

Vesicular glutamate transporter 3
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: SLC17A8
name: VGLU3_HUMAN
xref: UnificationXref2675
feature: FragmentFeature214
cellular location: intracellular
comment: Reactome DB_ID: 4230852
display name: Q7A3I9

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3I9
data source: Reactome
name: Vesicular glutamate transporter 2
name: SLC17A6
name: VGLU2_HUMAN
xref: UnificationXref2674
feature: FragmentFeature213
cellular location: intracellular
comment: Reactome DB_ID: 4230851
display name: Q7A3I9

TTP
type: SmallMoleculeReference
name: Deoxythymidine 5'-triphosphate
name: dTTP
name: Deoxythymidine triphosphate
name: dTTP [ChEBI:18077]
xref: UnificationXref1329

UnificationXref768
type: UnificationXref
id: REACT_5115
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5115.1

UnificationXref769
type: UnificationXref
id: CHEBI:422
db: ChEBI

UnificationXref766
type: UnificationXref
id: CHEBI:16908
db: ChEBI

UnificationXref767
type: UnificationXref
id: 73473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73473

UnificationXref764
type: UnificationXref
id: 4231339
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231339

UnificationXref765
type: UnificationXref
id: REACT_135331
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135331.5

Homologues of SLC30A3
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q7A824
xref: UnificationXref2786
cellular location: intracellular
comment: Reactome DB_ID: 4230928
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4C2
data source: Reactome
name: Zinc transporter 2
name: SLC30A2
name: Q7A4C2
name: ZNT2_HUMAN
xref: UnificationXref2778
feature: FragmentFeature226
cellular location: intracellular
comment: Reactome DB_ID: 4230922
display name: ZnT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4C2
data source: Reactome
name: Zinc transporter 3
name: ZNT3_HUMAN
name: SLC30A3
name: Q7A4C2
xref: UnificationXref2785
feature: FragmentFeature228
cellular location: intracellular
comment: Reactome DB_ID: 4230927
display name: ZnT3

Q7A824
type: Protein
entity reference: Q7A824
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Zinc transporter 3
name: ZNT3_HUMAN
name: SLC30A3
xref: UnificationXref2784
feature: FragmentFeature227
cellular location: intracellular
comment: Reactome DB_ID: 4230926
display name: ZnT3

Q7A824
type: Protein
entity reference: Q7A824
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: SLC30A8
name: Zinc transporter 8
name: ZNT8_HUMAN
xref: UnificationXref2792
feature: FragmentFeature229
cellular location: intracellular
comment: Reactome DB_ID: 4230931
display name: ZnT8

UnificationXref750
type: UnificationXref
id: 4231337
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231337

Homologues of SLC30A8
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
member physical entity: Q7A824
xref: UnificationXref2794
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230933

UnificationXref752
type: UnificationXref
id: CHEBI:15375
db: ChEBI

UnificationXref751
type: UnificationXref
id: REACT_157459
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157459.3

SLC11A2
type: Protein
entity reference: UniProt:Q99UZ7
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: NRAM2_HUMAN
name: Natural resistance-associated macrophage protein 2
name: Q99UZ7
name: NRAMP2
xref: UnificationXref2769
feature: FragmentFeature224
cellular location: plasma membrane
comment: Reactome DB_ID: 4230914
display name: DCT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4P8
data source: Reactome
name: Solute carrier family 13 member 5
name: S13A5_HUMAN
name: SLC13A5
xref: UnificationXref2762
feature: FragmentFeature223
cellular location: plasma membrane
comment: Reactome DB_ID: 4230900
display name: Q7A4P8

Q7A824
type: Protein
entity reference: Q7A824
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Zinc transporter 2
name: SLC30A2
name: ZNT2_HUMAN
xref: UnificationXref2776
feature: FragmentFeature225
cellular location: intracellular
comment: Reactome DB_ID: 4230919
display name: ZnT2

Homologues of SLC30A2
type: Protein
data source: Reactome
member physical entity: Q7A824
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2779
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230923

http://identifiers.org/pubmed/15802217
type: PublicationXref
id: 15802217
author: Coulter-Mackie, MB
author: Wong, SG
author: Lian, Q
db: Pubmed
title: Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor
source: Protein Expr Purif 41:18-26
year: 2005

UnificationXref753
type: UnificationXref
id: 1497857
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1497857

http://identifiers.org/pubmed/20162368
type: PublicationXref
id: 20162368
author: Ueki, I
author: Stipanuk, MH
db: Pubmed
title: Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
source: J Inherit Metab Dis 34:17-32
year: 2011

UnificationXref754
type: UnificationXref
id: REACT_111511
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_111511.1

UnificationXref755
type: UnificationXref
id: P99079
db: UniProt

UnificationXref756
type: UnificationXref
id: 4230551
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230551

UnificationXref757
type: UnificationXref
id: 4231125
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231125

UnificationXref758
type: UnificationXref
id: 4231127
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231127

UnificationXref759
type: UnificationXref
id: REACT_141934
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_141934.5

Homologues of SLC28A3
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2859
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230292

CNT 1
type: Protein
entity reference: Q7A7A0
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7A7A0
name: Sodium-coupled nucleoside transporter 1
name: Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1)
name: Na(+)/nucleoside cotransporter 1
name: Sodium/nucleoside cotransporter 1
name: Concentrative nucleoside transporter 1
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
name: SLC28A1
name: hCNT1
xref: UnificationXref2844
feature: FragmentFeature235
cellular location: plasma membrane
comment: Reactome DB_ID: 4230285
display name: CNT1

http://identifiers.org/pubmed/12684532
type: PublicationXref
id: 12684532
author: Kabashima, T
author: Uyeda, K
author: Wadzinski, BE
author: Kawaguchi, T
db: Pubmed
title: Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
source: Proc Natl Acad Sci U S A 100:5107-12
year: 2003

CNT 1
type: Protein
entity reference: Q7A706
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 1
name: Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1)
name: Q7A706
name: Na(+)/nucleoside cotransporter 1
name: Sodium/nucleoside cotransporter 1
name: Concentrative nucleoside transporter 1
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
name: SLC28A1
name: hCNT1
xref: UnificationXref2842
feature: FragmentFeature234
cellular location: plasma membrane
comment: Reactome DB_ID: 4230282
display name: CNT1

CNT 1
type: Protein
entity reference: Q7A7P7
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Sodium-coupled nucleoside transporter 1
name: Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1)
name: Na(+)/nucleoside cotransporter 1
name: Sodium/nucleoside cotransporter 1
name: Concentrative nucleoside transporter 1
name: Q7A7P7
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
name: SLC28A1
name: hCNT1
xref: UnificationXref2840
feature: FragmentFeature233
cellular location: plasma membrane
comment: Reactome DB_ID: 4230279
display name: CNT1

UnificationXref741
type: UnificationXref
id: 4230608
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230608

UnificationXref740
type: UnificationXref
id: 4230607
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230607

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7P7
data source: Reactome
name: sodium-coupled nucleoside transporter, member 3
name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
name: SLC28A3
xref: UnificationXref2856
feature: FragmentFeature236
cellular location: plasma membrane
comment: Reactome DB_ID: 4230289
display name: Q7A7P7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4C2
data source: Reactome
name: SLC30A8
name: Zinc transporter 8
name: Q7A4C2
name: ZNT8_HUMAN
xref: UnificationXref2793
feature: FragmentFeature230
cellular location: intracellular
comment: Reactome DB_ID: 4230932
display name: ZnT8

Homologues of SLC28A1
type: Protein
data source: Reactome
member physical entity: CNT 1
xref: UnificationXref2845
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230286

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A430
data source: Reactome
name: Q7A430
name: UT2_HUMAN
name: Urea transporter, kidney
name: SLC14A2
xref: UnificationXref2814
feature: FragmentFeature232
cellular location: plasma membrane
comment: Reactome DB_ID: 4230939
display name: HUT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A430
data source: Reactome
name: Q7A430
name: Urea transporter, erythrocyte
name: UT1_HUMAN
name: SLC14A1
xref: UnificationXref2813
feature: FragmentFeature231
cellular location: plasma membrane
comment: Reactome DB_ID: 4230938
display name: HUT11

Urea transporters
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2815
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230940

UnificationXref744
type: UnificationXref
id: CHEBI:15372
db: ChEBI

UnificationXref745
type: UnificationXref
id: 29870
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29870

UnificationXref742
type: UnificationXref
id: 4230612
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230612

UnificationXref743
type: UnificationXref
id: REACT_159150
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159150.3

UnificationXref748
type: UnificationXref
id: 4230604
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230604

Latent infection of Homo sapiens with Mycobacterium tuberculosis
type: Pathway
data source: Reactome
pathway component: Phagosomal maturation (early endosomal stage)
evidence: Evidence308
xref: UnificationXref2275
xref: RelationshipXref371
xref: UnificationXref2274
pathway order: PathwayStep301
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref749
type: UnificationXref
id: REACT_153542
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153542.3

UnificationXref746
type: UnificationXref
id: REACT_2495
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2495.2

http://identifiers.org/pubmed/10583946
type: PublicationXref
id: 10583946
author: Wood, RD
author: Lindahl, T
db: Pubmed
title: Quality control by DNA repair
source: Science 286:1897-905
year: 1999

UnificationXref747
type: UnificationXref
id: 4230603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230603

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64125
data source: Reactome
name: Ferrochelatase
name: P64125
name: HEMZ_HUMAN
xref: UnificationXref2045
feature: FragmentFeature151
cellular location: intracellular
comment: Reactome DB_ID: 4230479
display name: FECH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A664
data source: Reactome
name: Protoheme IX farnesyltransferase, mitochondrial ecNumber2.5.1.-/ecNumber
name: COX10(?-443)
name: COX10_HUMAN
name: Q7A664
xref: UnificationXref2057
feature: FragmentFeature152
cellular location: intracellular
comment: Reactome DB_ID: 4231247
display name: COX10

Q7A7V4
type: Protein
entity reference: Q7A7V4
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: alcohol dehydrogenase 1A (class I), alpha polypeptide
name: Alcohol dehydrogenase alpha chain
xref: UnificationXref2071
feature: FragmentFeature153
cellular location: intracellular
comment: Reactome DB_ID: 4230049
display name: ADH1A

Q7A7V4
type: Protein
entity reference: Q7A7V4
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: alcohol dehydrogenase 4 (class II), pi polypeptide
name: Alcohol dehydrogenase class II pi chain precursor
xref: UnificationXref2073
feature: FragmentFeature154
cellular location: intracellular
comment: Reactome DB_ID: 4230051
display name: ADH4

Q7A7V4
type: Protein
entity reference: Q7A7V4
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: alcohol dehydrogenase 6 (class V)
xref: UnificationXref2075
feature: FragmentFeature155
cellular location: intracellular
comment: Reactome DB_ID: 4230053
display name: ADH6

Q7A7V4
type: Protein
entity reference: Q7A7V4
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
name: Gastric alcohol dehydrogenase
name: Retinol dehydrogenase
name: Alcohol dehydrogenase class IV mu/sigma chain
xref: UnificationXref2077
feature: FragmentFeature156
cellular location: intracellular
comment: Reactome DB_ID: 4230055
display name: ADH7

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99TD1
data source: Reactome
name: Q99TD1
name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
name: acyl-CoA synthetase short-chain family member 1
xref: UnificationXref2088
feature: FragmentFeature157
cellular location: intracellular
comment: Reactome DB_ID: 4230961
display name: ACSS1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99TD1
data source: Reactome
name: Q99TD1
name: AceCS
name: Acyl-activating enzyme
name: Acetate--CoA ligase
name: Acetyl-coenzyme A synthetase, cytoplasmic
name: ACSS2
name: Acetyl-CoA synthetase
xref: UnificationXref2093
feature: FragmentFeature158
cellular location: intracellular
comment: Reactome DB_ID: 4230062
display name: ACS

Evidence299
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12717451
xref: http://identifiers.org/pubmed/17117926
xref: http://identifiers.org/pubmed/17397399
xref: http://identifiers.org/pubmed/22108505
xref: http://identifiers.org/pubmed/8167409
comment: All WNT ligands are predicted to be highly glycosylated. By similarity with WNT ligands in mouse, human WNTs are believed to undergo N-linked glycosylation at multiple asparagine residues and this glycosylation is critical for their secretion (Smolich et al, 1993; Willert et al, 2003, Komekado et al, 2006; Kurayoshi et al, 2007). The mechanism of N-linked glycosylation is not shown here. For a more detailed description, please refer to pathway "Asparagine N-linked glycosylation".

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A829
data source: Reactome
name: Q7A829
name: UDP-glucose dehydrogenase
xref: UnificationXref2104
feature: FragmentFeature159
cellular location: intracellular
comment: Reactome DB_ID: 4230426
display name: UGDH

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A331
data source: Reactome
name: Arylamine N-acetyltransferase 2
name: Q7A331
xref: UnificationXref2113
feature: FragmentFeature160
cellular location: intracellular
comment: Reactome DB_ID: 4230399
display name: NAT2

http://identifiers.org/pubmed/9792662
type: PublicationXref
id: 9792662
author: Morgunov, I
author: Srere, PA
db: Pubmed
title: Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
source: J Biol Chem 273:29540-29544
year: 1998

Q7A543
type: Protein
entity reference: Q7A543
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Alanine-glyoxylate aminotransferase
name: PXLP-AGXT
name: Serine-pyruvate aminotransferase
xref: UnificationXref1911
feature: FragmentFeature141
feature: ModificationFeature17
cellular location: intracellular
comment: Reactome DB_ID: 4230764
display name: AGXT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7L0
data source: Reactome
name: BHMT(1-406)
name: Q7A7L0
xref: UnificationXref1946
feature: FragmentFeature144
cellular location: intracellular
comment: Reactome DB_ID: 4231135
display name: BHMT

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A894
data source: Reactome
name: 2xHC-SQRDL(1-450)
name: SQR(ox.)
xref: UnificationXref1957
feature: ModificationFeature18
feature: FragmentFeature145
feature: ModificationFeature19
cellular location: intracellular
comment: Reactome DB_ID: 4231141
display name: Q7A894

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A6K3
data source: Reactome
name: Glyoxylate reductase/hydroxypyruvate reductase
name: Q7A6K3
xref: UnificationXref1923
feature: FragmentFeature142
cellular location: intracellular
comment: Reactome DB_ID: 4230770
display name: GRHPR

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P66767
data source: Reactome
name: MAT I/III
name: P66767
xref: UnificationXref1929
feature: FragmentFeature143
cellular location: intracellular
comment: Reactome DB_ID: 4230432
display name: MAT1A

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64341
data source: Reactome
name: HEM3_HUMAN
name: P64341
name: Porphobilinogen deaminase
xref: UnificationXref1994
feature: FragmentFeature148
cellular location: intracellular
comment: Reactome DB_ID: 4230455
display name: HMBS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67420
data source: Reactome
name: DCUP_HUMAN
name: Uroporphyrinogen III decarboxylase
name: P67420
xref: UnificationXref2008
feature: FragmentFeature149
cellular location: intracellular
comment: Reactome DB_ID: 4230467
display name: UROD

http://identifiers.org/pubmed/10828066
type: PublicationXref
id: 10828066
author: Jorgensen, R
author: Justesen, J
author: Sogaard, TM
author: Martensen, PM
author: Rossing, AB
db: Pubmed
title: Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase
source: J Biol Chem 275:16820-6
year: 2000

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A894
data source: Reactome
name: CysS-SQRDL(1-450)
name: SQR-S-SH
xref: UnificationXref1959
feature: ModificationFeature20
feature: FragmentFeature146
cellular location: intracellular
comment: Reactome DB_ID: 4231131
display name: Q7A894

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P64334
data source: Reactome
name: P64334
name: HEM2_HUMAN
name: Delta-aminolevulinic acid dehydratase
xref: UnificationXref1977
feature: FragmentFeature147
cellular location: intracellular
comment: Reactome DB_ID: 4230473
display name: ALAD

Protoporphyrinogen oxidase
type: Protein
entity reference: Q7A4W4
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Q7A4W4
name: PPOX_HUMAN
xref: UnificationXref2034
feature: FragmentFeature150
cellular location: intracellular
comment: Reactome DB_ID: 4230461
display name: PPOX

Evidence287
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10434065
xref: PublicationXref388
xref: http://identifiers.org/pubmed/11470804
xref: http://identifiers.org/pubmed/931988
xref: http://identifiers.org/pubmed/12616642
xref: http://identifiers.org/pubmed/11148549
xref: http://identifiers.org/pubmed/4403084
comment: Phenylacetate metabolism is of clinical importance because its conjugation with glutamine to form phenylacetylglutamine, which can be excreted in the urine, provides an alternative pathway for nitrogen excretion in patients with urea cycle defects (James et al. 1972; Batshaw et al. 2001; Brusilow and Horwich 2001). This conjugation proceeds in two steps. First, phenylacetate and ATP react with coenzyme A to form phenylacetyl CoA, AMP, and pyrophosphate (Vessey et al. 1999). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to phenylacetate metabolism in vivo are unknown. Second, phenylacetyl CoA and glutamine react to form phenyacetyl glutamine and Coenzyme A. The enzyme that catalyzes this reaction has been purified from human liver mitochondria and shown to be a distinct polypeptide species from glycine-N-acyltransferase (Webster et al. 1976). This human glutamine-N-acyltransferase activity has not been characterized by sequence analysis at the protein or DNA level, however, and thus cannot be associated with a known human protein in the annotation of phenylacetate conjugation.

5-acetamido-6-formamido-3-methyluracil
type: SmallMoleculeReference
name: ChEBI:32643 5-acetamido-6-formamido-3-methyluracil
xref: UnificationXref2156

Evidence286
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10434065
xref: http://identifiers.org/pubmed/11470804
xref: http://identifiers.org/pubmed/12616642
comment: Phenylacetate and ATP react with coenzyme A to form phenylacetyl CoA, AMP, and pyrophosphate (Vessey et al. 1999). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to phenylacetate metabolism in vivo are unknown.

Evidence285
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref388
comment: Benzoic acid, widely used as a food preservative, is converted to hippuric acid by activation and conjugation with glycine. This was one of the first detoxification pathways discovered, and was formerly exploited clinically as an alternative means of nitrogen excretion in patients with urea cycle defects (Brusilow and Horwich 2001).

Evidence284
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10434065
xref: http://identifiers.org/pubmed/11470804
xref: http://identifiers.org/pubmed/12616642
comment: Benzoate and ATP react with coenzyme A to form benzoyl CoA, AMP, and pyrophosphate (Vessey et al. 1999, 2003). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to benzoate metabolism in vivo are unknown.

Evidence283
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10898761
xref: http://identifiers.org/pubmed/15130560
xref: PublicationXref469
xref: http://identifiers.org/pubmed/10331075
comment: Methylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the second most widely used enzyme substrate after ATP and is involved in a wide range of important biological processes. SAM is sythesized from methionine's reaction with ATP, catalyzed by methionine adenosyltransferase (MAT). There are two genes, MAT1A and MAT2A, which encode for two homologous MAT catalytic subunits, 1 and 2. During conjugation with nucleophilic substrates, the methyl group attached to the sulfonium ion of SAM is transferred to the substrate forming the conjugate. SAM, having lost the methyl moiety, is converted to S-adenosylhomocysteine (SAH). SAH can be hydrolyzed to form adenosine and homocysteine. Homocysteine can either be converted to glutathione or methylated to form methionine, thus forming the starting point for SAM synthesis and completing the cycle. Fuctional groups attacked are phenols, catechols, aliphatic and aromatic amines and sulfhydryl-containing groups. The enzymes that catalyze the transfer of the methyl group to these functional groups are the methyltransferases (MT). MTs are small, cytosolic, monomeric enzymes that utilize SAM as a methyl donor. There are many MTs but the best studied ones are named on the basis of their prototypical substrates: COMT (catechol O-methyltransferase), TPMT (thiopurine methyltransferase), TMT (thiol methyltransferase), HNMT (histamine N-methyltransferase) and NNMT (nicotinamide N-methyltransferase). An example of each enzyme mentioned is given. In each case, a typical substrate for the enzyme is shown.

Evidence282
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2340091
xref: http://identifiers.org/pubmed/1559981
xref: PublicationXref469
xref: http://identifiers.org/pubmed/12052143
comment: N-acetyltransferases (NATs; EC 2.3.1.5) utilize acetyl Co-A in acetylation conjugation reactions. This is the preferred route of conjugating aromatic amines (R-NH2, converted to aromatic amides R-NH-COCH3) and hydrazines (R-NH-NH2, converted to R-NH-NH-COCH3). Aliphatic amines are not substrates for NAT. The basic reaction is Acetyl-CoA + an arylamine = CoA + an N- acetylarylamine NATs are cytosolic and in humans, 2 isoforms are expressed, NAT1 and NAT2. A third isoform, NATP, is a pseudogene and is not expressed. The NAT2 gene contains mutations that decrease NAT2 activity. This mutations was first seen as slow acetylation compared to the normal, fast acetylation of the antituberculosis drug isoniazid. Incidence of the slow acetylator phenotype is high in Middle Eastern populations (70%), average (50%) in Europeans, Americans and Australians and low in Asians (<25% in Chinese, Japanese and Koreans). N-acetylation and methylation pathways differ from other conjugation pathways in that they mask an amine with a nonionizable group so that the conjugates are less water soluble than the parent compound. However, certain N-acetlylations facilitate urinary excretion. N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a cysteine residue in NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is released from the acetylated NAT to the substrate, subsequently regenerating the enzyme.

Evidence281
type: Evidence
evidence code: inferred from electronic annotation
comment: Typical NAT 2 substrates were chosen as examples. They are paraxanthine, isoniazid and N-hydroxy 4-aminobiphenyl.

Evidence280
type: Evidence
evidence code: inferred from electronic annotation
comment: Typical NAT 1 substrates were chosen as examples. They are sulfanilamide, 4-aminosalicylate, 4-aminobenzoate and N-hydroxy 4-aminobiphenyl.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99129
data source: Reactome
name: Glycyl-tRNA synthetase
name: P99129
name: GARS(55-739)
xref: UnificationXref2332
feature: FragmentFeature172
cellular location: intracellular
comment: Reactome DB_ID: 4230683
display name: GARS

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P67572
data source: Reactome
name: P67572
name: Asparaginyl-tRNA synthetase 2
xref: UnificationXref2348
feature: FragmentFeature173
cellular location: intracellular
comment: Reactome DB_ID: 4230730
display name: NARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:P67015
data source: Reactome
name: Aspartyl-tRNA synthetase 2
name: P67015
xref: UnificationXref2360
feature: FragmentFeature174
cellular location: intracellular
comment: Reactome DB_ID: 4230735
display name: DARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99170
data source: Reactome
name: P99170
name: Glutamyl-tRNA synthetase 2
xref: UnificationXref2371
feature: FragmentFeature175
cellular location: intracellular
comment: Reactome DB_ID: 4230720
display name: EARS2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A4Q7
data source: Reactome
name: SC5A7_HUMAN
name: Q7A4Q7
name: High affinity choline transporter 1
name: SLC5A7
xref: UnificationXref2304
feature: FragmentFeature169
cellular location: plasma membrane
comment: Reactome DB_ID: 4230640
display name: CHT

http://identifiers.org/pubmed/8327470
type: PublicationXref
id: 8327470
author: Murer, H
author: Stange, G
author: Biber, J
author: Sorribas, V
author: Markovich, D
author: Magagnin, S
author: Werner, A
db: Pubmed
title: Expression cloning of human and rat renal cortex Na/Pi cotransport
source: Proc Natl Acad Sci U S A 90:5979-83
year: 1993

Astrocytic EAATs
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2315
cellular location: plasma membrane
comment: Reactome DB_ID: 4230635
comment: Converted from EntitySet in Reactome

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: Q7A7I9
name: SLC1A3
xref: UnificationXref2313
feature: FragmentFeature170
cellular location: plasma membrane
comment: Reactome DB_ID: 4230633
display name: EAAT1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: SLC1A2
name: Q7A7I9
xref: UnificationXref2314
feature: FragmentFeature171
cellular location: plasma membrane
comment: Reactome DB_ID: 4230634
display name: EAAT2

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: P99129
data source: Reactome
name: Glycyl-tRNA synthetase
name: P99129
xref: UnificationXref2380
feature: FragmentFeature176
cellular location: intracellular
comment: Reactome DB_ID: 4230751
display name: GARS

Evidence279
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1559981
comment: N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a conserved cysteine residue (position 68) in the active site of NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is transferred to the acceptor substrate and the enzyme returns to its initial state.

P67509
type: Protein
entity reference: P67509
data source: Reactome
name: Note: the coordinates are copied over from Homo sapiens.
name: Isoleucyl-tRNA synthetase 2
xref: UnificationXref2394
feature: FragmentFeature177
cellular location: intracellular
comment: Reactome DB_ID: 4230700
display name: IARS2

Evidence277
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10836148
xref: http://identifiers.org/pubmed/14977861
xref: PublicationXref469
comment: Glucuronidation conjugation utilizes UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17) to catalyze a wide range of diverse endogenous and xenobiotic compounds. Glucuronidation is the major pathway in phase II metabolism and accounts for approximately 35% of drug conjugation. UGTs are microsomal membrane-bound and catalyze the transfer of a glucuronate group of uridine diphosphoglucuronate (UDPGA, a co-substrate) to the functional group of specific substrates. UDPGA is synthesized from glucose-1-phosphate (G1P). G1P is required for glycolysis and is present in high concentrations in the cell, making it is unlikely to be a limiting factor in UDPGA synthesis. UDP is added to G1P to form UDP-glucose which is then dehydrogenated to form UDPGA. The basic reaction is UDP-Glucuronate + acceptor -> UDP + acceptor-beta-D-glucuronide The effect of this conjugation is to confer polarity to the substrate which can then be easily excreted in urine or bile. Functional groups acted on include hydroxyl, carboxylate, amino and sulfate groups. There are 2 families of UGTs, UGT1 and UGT2 which are further sub-divided into 3 subfamilies, UGT1A, UGT2A and UGT2B. There are more than 26 different isozymes in humans, of which 18 are functional proteins. They are composed of 527-530 residues and have a molecular weight of 50-57KDa. The UGT1 family comprises of 9 proteins (UGT1A1, 1A3-1A10) but only 5 have been isolated in humans. Example substrates which are glucuronidated are acetaminophen by UGT1A6 and bilirubin by UGT1A1. Members of the UGT2 subfamily are each encoded by their own genes, in contrast to UGT1As which are encoded at the UGT1 locus. Example substrates are morphine conjugation by UGT2B7 and androgenic steroid conjugation by UGT2B17. Xenobiotics conjugated with glucuronic acid can be substrates for beta-glucuronidase, an enzyme common in gut microflora. This enzyme can release the parent or phase I metabolite which can be reabsorbed. It can then either re-exert it's original eff…

Evidence278
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1559981
comment: N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a conserved cysteine residue (position 68) in the active site of NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is transferred to the acceptor substrate and the enzyme returns to its initial state.

Evidence296
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18479171
comment: Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008).

Evidence295
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/1383219
comment: Cytosolic GUK1 (guanylate kinase 1) catalyzes the reaction of carbovir monophosphate and ATP to form carbovir diphosphate and ADP. The activity of human GUK1 is inferred from that of the corresponding pig protein (Miller et al. 1992).

Evidence298
type: Evidence
evidence code: inferred from electronic annotation
comment: Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether they involve carbohydrate-derived or lipid-derived molecules, and within each group it is useful to distinguish processes that mediate the breakdown and oxidation of these molecules to yield energy from ones that mediate their synthesis and storage as internal energy reserves. Synthetic reactions are conveniently grouped by the chemical nature of the end products, such as nucleotides, amino acids and related molecules, and porphyrins. Detoxification reactions (biological oxidations) are likewise conveniently classified by the chemical nature of the toxin. At the same time, all of these processes are tightly integrated. Intermediates in reactions of energy generation are starting materials for biosyntheses of amino acids and other compounds, broad-specificity oxidoreductase enzymes can be involved in both detoxification reactions and biosyntheses, and hormone-mediated signaling processes function to coordinate the operation of energy-generating and energy-storing reactions and to couple these to other biosynthetic processes.

Evidence297
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18479171
comment: Abacavir is a nucleoside analogue reverse transcriptase inhibitor with antiretroviral activity, widely used in combination with other drugs to treat HIV-1 infection (Yuen et al. 2008). Its uptake across the plasma membrane is mediated by organic cation transporters SLC22A1, 2, and 3; the transport proteins ABCB1 and ABCG2 mediate its efflux. Abacavir itself is a prodrug. Activation requires phosphorylation by a cytosolic adenosine phosphotransferase and deamination by ADAL deaminase to yield carbovir monophosphate. Cytosolic nucleotide kinases convert carbovir monophosphate to carbovir triphosphate, the active HIV reverse transcriptase inhibitor. Abacavir can be glucuronidated or oxidized to a 5'-carboxylate; these are the major forms in which it is excreted from the body.

Evidence292
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11805192
xref: PublicationXref469
comment: Phase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involved are a set of transferases which perform the transfer of the cofactor group to the substrate. The resultant conjugation results in greatly increasing the excretory potential of compounds. Although most conjugations result in pharmacological inactivation or detoxification, some can result in bioactivation. Most of the phase II enzymes are located in the cytosol except UDP-glucuronosyltransferases (UGT), which are microsomal. Phase II reactions are typically much faster than phase I reactions therefore the rate-limiting step for biotransformation of a compound is usually the phase I reaction. Phase II metabolism can deal with all the products of phase I metabolism, be they reactive (Type I substrate) or unreactive/poorly active (Type II substrate) compounds. With the exception of glutathione, the conjugating species needs to be made chemically reactive after synthesis. The availability of the cofactor in the synthesis may be a rate-limiting factor in some phase II pathways as it may prevent the formation of enough conjugating species to deal with the substrate or it's metabolite. As many substrates and/or their metabolites are chemically reactive, their continued presence may lead to toxicity.

Evidence291
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref469
comment: Xenobiotics that contain either a carboxylic group or an aromatic hydroxylamine group are possible substrates for amino acid conjugation. Xenobiotics with a carboxylic group conjugate with an amino group of amino acids such as glycine, taurine and glutamine. The hydroxylamine group conjugates with the carboxylic group of amino acids such as proline and serine. The amino acid is first activated by an aminoacyl-tRNA-synthetase which then reacts with the hydroxylamine group to form a reactive N-ester. N-esters can degrade to form electrophilic nitrenium (R-N+-R') and carbonium (R-C+H2) ions. The pyrolysis product of tryptophan, an N-hydroxy intermediate, can potentially form these reactive electrophilic ions.

Evidence294
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12399160
comment: Cytosolic ADH alpha dimer catalyzes the reaction of abacavir and NAD to form abacavir 5'-carboxylate and NADH + H+. Abacavir 5'-carboxylate is one of the major forms in which abacavir is excreted from the body. Studies with purified enzymes in vitro indicate that only the alpha isoform of ADH has this activity. These studies also suggest that the reaction proceeds in two steps via an unstable aldehyde intermediate (Walsh et al. 2002). Whether conversion of the aldehyde to the carboxylate is spontaneous or also catalyzed by ADH has not been established.

Phagosomal maturation (early endosomal stage)
type: Pathway
data source: Reactome
pathway component: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
pathway component: BiochemicalReaction186
evidence: Evidence307
xref: UnificationXref2272
xref: UnificationXref2273
xref: RelationshipXref370
pathway order: PathwayStep1
pathway order: PathwayStep300
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence293
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref462
comment: All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common. The very nature of many chemicals that make them suitable for uptake by these routes, in other words their lipophilicty (favours fat solubility) is also the main reason organisms have developed mechanisms that convert them to hydrophilic (favours water solubility) compounds which are readily excreted via bile and urine. Otherwise, lipophilic chemicals would accumulate in the body and overwhelm defense mechanisms. This process is called biotransformation and is catalyzed by enzymes mainly in the liver of higher organisms but a number of other organs have considerable ability to process xenobiotica such as kidneys, gut and lungs. As well as xenobiotics, many endogenous compounds are commonly eliminated by this process. This mechanism is of ancient origin and a major factor for its development in animals is plants. Most animals are plant eaters and thus are subject to a huge variety of chemical compounds which plants produce to stop themselves being eaten. This complex set of enzymes have several features which make them ideal for biotransformation; (1) metabolites of the parent chemical are usually made more water soluble so it favours rapid excretion via bile and urine (2) the enzymes possess broad and overlapping specificity to be able to deal with newly exposed chemicals (3) metabolites of the parent generally don't have adverse biological effects. In the real world however, all these criteria have exceptions. Many chemicals are transformed into reactive metabolites. In pharmacology, the metabolites of some parent drugs exert the desired pharmacological effect but in the case of polycyclic aromatic hydrocarbons (PAHs), which can undergo epoxidation, it results in the formation of an electrophile which can …

http://identifiers.org/pubmed/17215883
type: PublicationXref
id: 17215883
author: Cellier, MF
author: Courville, P
author: Chaloupka, R
db: Pubmed
title: Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters
source: Biochem Cell Biol 84:960-78
year: 2006

Evidence290
type: Evidence
evidence code: inferred from electronic annotation
comment: Xenobiotics and endogenous compounds containing carboxylate groups can be activated with coenzyme A to produce acyl-CoA thioesters and then conjugated with the amino groups of glycine or glutamine to form amide-linked conjugates. Clinically important substrates include benzoic acid, phenylacetic acid, and salicylic acid.

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q99UZ7
data source: Reactome
name: SLC11A1
name: Natural resistance-associated macrophage protein 1
name: NRAM1_HUMAN
name: Q99UZ7
xref: UnificationXref2269
feature: FragmentFeature165
cellular location: intracellular
comment: Reactome DB_ID: 4230911
display name: NRAMP1

Neuronal EAATs
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2296
cellular location: plasma membrane
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230630

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3A2
data source: Reactome
name: middle-chain acyl-CoA synthetase 1
name: Q7A3A2
xref: UnificationXref2178
feature: FragmentFeature163
cellular location: intracellular
comment: Reactome DB_ID: 4230406
display name: ACSM1

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: UniProt:Q7A5G9
data source: Reactome
name: Q7A5G9
name: Short-chain dehydrogenase/reductase 3 ecNumber1.1.1.300/ecNumber
name: DHRS3_HUMAN
xref: UnificationXref2246
feature: FragmentFeature164
cellular location: intracellular
comment: Reactome DB_ID: 4231208
display name: DHRS3

http://identifiers.org/pubmed/10858654
type: PublicationXref
id: 10858654
author: Kühl, Michael
author: Park, M
author: Moon, Randall T
author: Sheldahl, L C
author: Miller, J R
db: Pubmed
title: The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape
source: Trends Genet. 16:279-83
year: 2000

xenobiotic/medium-chain fatty acid:CoA ligases
type: Protein
data source: Reactome
member physical entity: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2179
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230407

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A3A2
data source: Reactome
name: Q7A3A2
name: Xenobiotic/medium-chain fatty acid:CoA ligase
xref: UnificationXref2177
feature: FragmentFeature162
cellular location: intracellular
comment: Reactome DB_ID: 4230405
display name: ACSM2B

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A331
data source: Reactome
name: Acyl-NAT2 intermediate
name: AcC-NAT2
xref: UnificationXref2115
feature: ModificationFeature21
feature: FragmentFeature161
cellular location: intracellular
comment: Reactome DB_ID: 4230401
display name: Q7A331

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: Q7A7I9
name: SLC1A7
xref: UnificationXref2295
feature: FragmentFeature168
cellular location: plasma membrane
comment: Reactome DB_ID: 4230629
display name: EAAT5

Evidence288
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/5862532
xref: http://identifiers.org/pubmed/12616642
comment: Salicylate and ATP react with coenzyme A to form salicylate CoA, AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003).

Evidence289
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7802672
xref: http://identifiers.org/pubmed/12616642
comment: In the body, aspirin (acetylsalicylic acid) is hydrolyzed to salicylic acid. Salicylic acid (2-hydroxybenzoic acid) can then be hydroxylated to yield gentisic acid, conjugated with glucuronate, or conjugated with glycine to yield molecules that are excreted by the kidneys. The third of these conjugation processes is annotated here, and proceeds in two steps. First, salicylate and ATP react with coenzyme A to form salicylate CoA, AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Second, salicylate CoA and glycine react to form salicyluric acid and Coenzyme A (Mawal and Qureshi 1994).

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: Q7A7I9
name: SLC1A1
xref: UnificationXref2293
feature: FragmentFeature166
cellular location: plasma membrane
comment: Reactome DB_ID: 4230627
display name: EAAT3

Note: the coordinates are copied over from Homo sapiens.
type: Protein
entity reference: Q7A7I9
data source: Reactome
name: Q7A7I9
name: SLC1A6
xref: UnificationXref2294
feature: FragmentFeature167
cellular location: plasma membrane
comment: Reactome DB_ID: 4230628
display name: EAAT4

Glycolysis
type: Pathway
data source: Reactome
pathway component: 1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
pathway component: dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
pathway component: 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
pathway component: phosphoenolpyruvate + ADP => pyruvate + ATP
pathway component: D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
pathway component: Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
pathway component: Glucose 6-phosphate is isomerized to form fructose-6-phosphate
evidence: Evidence17
xref: RelationshipXref19
xref: UnificationXref170
xref: UnificationXref169
pathway order: PathwayStep12
pathway order: PathwayStep9
pathway order: PathwayStep7
pathway order: PathwayStep13
pathway order: PathwayStep11
pathway order: PathwayStep8
pathway order: PathwayStep10
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence260
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11032836
comment: Lead binds to ALAD enzyme displacing half the zinc ions essential for its catalytic activity and inactivating it. Lead is a major environmental toxin and this enzyme is one of its principal molecular targets (Jaffe et al. 2001).

Sphingolipid metabolism
type: Pathway
data source: Reactome
pathway component: Sphingolipid de novo biosynthesis
evidence: Evidence91
xref: RelationshipXref104
xref: UnificationXref673
xref: UnificationXref674
pathway order: PathwayStep87
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence261
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10706561
xref: http://identifiers.org/pubmed/11032836
xref: http://identifiers.org/pubmed/15381398
xref: http://identifiers.org/pubmed/7354072
xref: http://identifiers.org/pubmed/11032841
comment: 5-Aminolevulinic acid dehydratase (ALAD aka porphobilinogen synthase, PBGS), catalyzes the asymmetric condensation of two molecules of ALA to form porphobilinogen (PBG). The substrate that becomes the acetyl side chain-containing half of PBG is called A-side ALA; the half that becomes the propionyl side chains and the pyrrole nitrogen is called P-ALA (Jaffe 2004). PBG is the first pyrrole formed, the precursor to all tetrapyrrole pigments such as heme and chlorophyll. There are at least eight bonds that are made or broken during this reaction. The active form of the ALAD enzyme is an octamer complexed with eight Zn2+ ions, four that are strongly bound and four that are weakly bound. The four weakly bound ones are dispensible for enzyme activity in vitro (Bevan et al. 1980; Mitchell et al. 2001). Deficiencies of ALAD enzyme in vivo are associated with 5-aminolevulinate dehydratase-deficient porphyria (e.g., Akagi et al. 2000).

Evidence264
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8644733
xref: http://identifiers.org/pubmed/6822570
xref: http://identifiers.org/pubmed/9564029
comment: Cytosolic uroporphyrinogen decarboxylase (UROD) catalyzes the sequential removal of four carboxylic groups from the acetic acid side chains of uroporphyrinogen I (URO1) to form coproporphyrinogen I (COPRO1). UROD catalyzes this reaction less efficiently than the decarboxylation of uroporphyrinogen III (de Verneuil et al. 1983).

Evidence265
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8771201
comment: Six electrons are oxidized in protophorphyrinogen IX (PPGEN9) to form the planar macrocycle protoporphyrin IX (PRIN9). This reaction is performed by the enzyme protoporphyrinogen oxidase (PPO). PPO functions as a homodimer containing one non-covalently-bound FAD. The protein resides on the outer surface of the inner mitochondrial membrane. PPO deficiency is associated with variegate porphyria in vivo.

Evidence262
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12773194
xref: http://identifiers.org/pubmed/7354069
comment: Cytosolic porphobilinogen deaminase catalyzes the polymerization of four molecules of porphobilinogen (PBG) to generate hydroxymethylbilane (HMB), an unstable tetrapyrrole. This reaction is the first step in the formation of the tetrapyrrole macrocycle. Two isoforms of porphobilinogen deaminase are generated by alternative splicing, one expresssed in erythroid tissues and one ubiquitously expressed in the body. Deficiencies of both forms of PBG deaminase are associated with acute intermittent porphyria.

Evidence263
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8644733
xref: http://identifiers.org/pubmed/6822570
xref: http://identifiers.org/pubmed/9564029
comment: Cytosolic uroporphyrinogen decarboxylase (UROD) catalyzes the sequntial removal of four carboxylic groups from the acetic acid side chains of uroporphyrinogen III (URO3) to form coproporphyrinogen III (COPRO3) (de Verneuil et al. 1983). Human UROD is a dimer (Whitby et al. 1998). Heterogenous and homogenous deficiencies of UROD are associated with porphyria cutanea tarda and hepatoerythropoietic porphyria respectively in vivo (Moran-Jiminez et al. 1996).

Evidence258
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16702333
comment: The main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic. This group of reactions contains all processes that 1) break down sulfur amino acids, 2) interconvert between them, and 3) synthesize them from solved sulfide which comes from sulfate assimilation and reduction. Only plants and microorganisms employ all processes. Humans cannot de novo synthesize any sulfur amino acid, nor convert cysteine to methionine (Brosnan & Brosnan, 2006).

Evidence257
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20162368
comment: While in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulfide, have uses in other biological processes (Stipanuk & Ueki 2011).

Evidence256
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/20162368
comment: While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters. The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated (Stipanuk & Ueki 2011).

Evidence255
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18494801
xref: http://identifiers.org/pubmed/12832624
comment: When SQR is in the oxidized state, it can bind hydrogen sulfide as persulfide to one of its own cysteine residue, the electrons being transferred to ubiquinone. After that the additional sulfur is dioxygenated by another enzyme (ETHE1). The activity of human SQR was deduced from the orthologue in Arenicola marina (Theissen et al. 2003, Hildebrandt & Grieshaber 2008).

Evidence259
type: Evidence
evidence code: inferred from electronic annotation
comment: This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine. Transport of these molecuels across lipid bilayer membranes is annotated separately as part of the module on "transmembrane transport of small molecules".

http://identifiers.org/pubmed/16503871
type: PublicationXref
id: 16503871
author: Gouni-Berthold, I
author: Krone, W
db: Pubmed
title: Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis
source: Curr Drug Targets Cardiovasc Haematol Disord 5:513-23
year: 2005

Evidence270
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/270680
xref: http://identifiers.org/pubmed/9982
xref: http://identifiers.org/pubmed/1985938
xref: http://identifiers.org/pubmed/10441588
xref: http://identifiers.org/pubmed/10697413
xref: http://identifiers.org/pubmed/1755855
xref: http://identifiers.org/pubmed/4748759
xref: http://identifiers.org/pubmed/427099
xref: http://identifiers.org/pubmed/6395883
xref: http://identifiers.org/pubmed/8074657
xref: http://identifiers.org/pubmed/4504607
comment: Cytosolic alcohol dehydrogenase catalyzes the reaction of ethanol and NAD+ to form acetaldehyde and NADH + H+. The active form of the enzyme is a dimer with one zinc ion bound to each protein subunit. In the body, alcohol dehydrogenase is present in the liver, kidney, lung and gastric mucosa. Six genes encode proteins active in ethanol oxidation: ADH1A, ADH1B, ADH1C, ADH4, ADH6, and ADH7 (Lange et al. 1976; Yin et al. 1985; Li et al. 1978; Bosron et al. 1979; Moreno and Pares 1991; Yokoyama et al. 1994; Chen and Yoshida 1991). ADH1A, B and C proteins can associate to form homodimers or heterodimers; ADH4, 6, and 7 proteins each form homodimers. Expression of ADH1A, B and C is developmentally regulated: ADH1A protein is abundant in the fetus, but expressed only at low levels in adulthood, when ADH1B and C proteins are abundant (Edenberg 2000). The various dimers differ substantially in the efficiency with which they oxidize ethanol. The ADH1B homodimer and heterodimers containing at least one 1B monomer are the most active towards ethanol (Yin et al. 1985). In addition, common polymorphic variants of ADH1B and C proteins differ substantially in this respect (Murray and Price 1972).

Evidence271
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16788062
comment: ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006).

Evidence272
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10843999
comment: Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Luong et al. 2000).

http://identifiers.org/pubmed/18457970
type: PublicationXref
id: 18457970
author: Schaid, DJ
author: Moon, I
author: Eckloff, BW
author: Li, F
author: Yee, V
author: Lee, C
author: Wieben, ED
author: Weinshilboum, RM
author: Pelleymounter, LL
author: Wang, S
author: Feng, Q
db: Pubmed
title: Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization
source: Mol Genet Metab 94:326-35
year: 2008

Evidence273
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2729894
xref: http://identifiers.org/pubmed/17567461
xref: http://identifiers.org/pubmed/9982
xref: http://identifiers.org/pubmed/3893466
xref: http://identifiers.org/pubmed/10441588
xref: http://identifiers.org/pubmed/18110463
xref: http://identifiers.org/pubmed/224930
comment: Ethanol and related alcohols can be ingested as part of the diet and are formed by microorganisms in the intestinal tract. Ethanol oxidation to acetate occurs primarily in liver cells in a multistep process first described by Racker (1949). First, in the cytosol, ethanol is oxidized to acetaldehyde, with the formation of NADH. Second, in the mitochondrion, acetaldehyde is oxidized to acetate with the formation of NADH. Finally, acetate in the mitochondrion can be condensed with coenzyme A to form acetyl CoA. Polymorphisms in the enzymes catalyzing the first two steps are associated with variation in the efficiency of alcohol catabolism in human populations (Chen et al. 1999; Lange et al. 1976; Jornvall 1985). The molecular mechanism by which cytosolic acetaldehyde enters the mitochondrial matrix is not known (Lemasters 2007). Cytosolic enzymes capable of oxidizing acetaldehyde to acetate have also been identified and characterized in vitro (Inoue et al. 1979) so a purely cytosolic pathway for ethanol oxidation to acetate and conversion to acetyl-CoA can be annotated. The role of this pathway in vivo is unclear, though limited attempts to correlate deficiencies in the cytosolic enzyme with alcohol intolerance have yielded suggestive data (Yoshida et al. 1989). Additional peroxisomal and microsomal pathways for the oxidation of ethanol to acetaldehyde have been described; their physiological significance is unclear and they are not annotated here.

Evidence274
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref462
xref: http://identifiers.org/pubmed/16584116
xref: http://identifiers.org/pubmed/17125408
xref: http://identifiers.org/pubmed/12369887
comment: Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions. There are two groups of enzymes in phase 1 - oxidoreductases and hydrolases. Oxidoreductases introduce an oxygen atom into or remove electrons from their substrates. The major oxidoreductase enzyme system is called the P450 monooxygenases. Other systems include flavin-containing monooxygenases (FMO), cyclooxygenases (COX) and monoamine oxidases (MAO). Hydrolases hydrolyse esters, amides, epoxides and glucuronides.

Evidence275
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15044486
comment: UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.

Evidence276
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17482904
comment: Glucose 1-phosphate and UTP are the precursors to UDP-glucuronate formation. After oxidation of the resultant complex, UDP-glucuronate is transported to the ER lumen.

Evidence267
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8078902
xref: http://identifiers.org/pubmed/9177788
comment: Heme O and heme A are specifically synthesised for the heme-copper respiratory oxidases. Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).

Evidence266
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11175906
xref: http://identifiers.org/pubmed/3327432
comment: Ferrochelatase (FECH) catalyzes the insertion of ferrous iron into protoporphyrin IX (PRIN9) to form heme. FECH is localized on the matrix surface of the inner mitochondrial membrane and this reaction takes place within the mitochondrial matrix. The enzyme functions as a homodimer with each monomer containing a nitric oxide-sensitive 2Fe-2S cluster. Enzyme deficiency is associated with erythropoietic protoporphyria in vivo, and inhibition of ferrochelatase activity is a clinically important consequence of lead poisoning (Piomelli et al. 1987).

Evidence269
type: Evidence
evidence code: inferred from electronic annotation
comment: Porphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the name itself, porphyrin, is derived from the Greek word for purple. The aromatic character of porphyrins can be seen by NMR spectroscopy. Porphyrins readily combine with metals by coordinating them in the central cavity. Iron (heme) and magnesium (chlorophyll) are two well known examples although zinc, copper, nickel and cobalt form other known metal-containing phorphyrins. A porphyrin which has no metal in the cavity is called a free base. Some iron-containing porphyrins are called hemes (heme-containing proteins or hemoproteins) and these are found extensively in nature ie. hemoglobin. Hemoglobin is quantitatively the most important hemoprotein. The hemoglobin iron is the transfer site of oxygen and carries it in the blood all round the body for cell respiration. Other examples are cytochromes present in mitochondria and endoplasmic reticulum which takes part in electron transfer events, catalase and peroxidase whic protect the body against the oxidant hydrogen peroxide and tryptophan oxygenase which is present in intermediary metabolism. Hemoproteins are synthesized in all mammalian cells and the major sites are erythropoietic tissue and the liver. The processes by which heme is synthesized, transported, and metabolized are a critical part of human iron metabolism (Severance and Hamze 2009); here the core processes of heme biosynthesis and catabolism have been annotated.

Evidence268
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16839620
xref: http://identifiers.org/pubmed/10522552
comment: Eight enzymes are involved in heme biosynthesis, four each in the mitochondria and the cytosol. The process starts in the mitochondria with the condensation of succinyl CoA (from the TCA cycle) and glycine to form 5-aminolevulinate (ALA). The next four steps take place in the cytosol. Two molecules of ALA are condensed to form the monopyrrole porphobilinogen (PBG). The next two steps convert four molecules of PBG into the cyclic tetrapyrrole uroporphyringen III, which is then decarboxylated into coproporphyrinogen III. The last three steps occur in the mitochondria and involve modifications to the tetrapyrrole side chains and finally, insertion of iron. In addition to these synthetic steps, a spontaneous cytosolic reaction allows the formation of uroporphyringen I which is then enzymatically decarboxylated to coproporphyrinogen I, which cannot be metabolized further in humans. Also, lead can inactivate ALAD, the enzyme that catalyzes PBG synthesis, and ferrochelatase, the enzyme that catalyzes heme synthesis. The porphyrias are disorders that arise from defects in the enzymes of heme biosynthesis. Defective pathway enzymes after ALA synthase result in accumulated substrates which can cause either skin problems, neurological complications, or both due to their toxicity in higher concentrations. They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction of the substrate. Each defect is described together with the reaction it affects.

http://identifiers.org/pubmed/12454260
type: PublicationXref
id: 12454260
author: Lowe, ME
db: Pubmed
title: The triglyceride lipases of the pancreas
source: J Lipid Res 43:2007-16
year: 2002

http://identifiers.org/pubmed/2536298
type: PublicationXref
id: 2536298
author: Franchi, A
author: Pouysségur, Jacques
author: Sardet, C
db: Pubmed
title: Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter
source: Cell 56:271-80
year: 1989

Evidence242
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/14738999
comment: Agmatine is polyamine formed by decarboxylation of L-arginine by arginine decarboxylase (ADC). Human ADC is a 460-amino acid protein that shows about 48% identity to mammalian ornithine decarboxylase (ODC) but has no ODC activity.

Pyrimidine metabolism
type: Pathway
data source: Reactome
pathway component: REACT 108541.9
pathway component: REACT 86439.9
pathway component: Pyrimidine salvage reactions
evidence: Evidence163
xref: RelationshipXref198
xref: UnificationXref1282
xref: UnificationXref1283
pathway order: PathwayStep150
pathway order: PathwayStep156
pathway order: PathwayStep159
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Evidence243
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11804860
xref: http://identifiers.org/pubmed/11914032
xref: http://identifiers.org/pubmed/15028567
comment: As it hydrolyzes a guanidino group within agmatine and also contains signature amino acid residues that act as ligand binding sites for the potential Mn(++) cofactor, agmatinase is classified as a member of the arginase superfamily (Morris, 2003).

Evidence240
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9722522
xref: http://identifiers.org/pubmed/2914937
xref: http://identifiers.org/pubmed/2324105
xref: http://identifiers.org/pubmed/15044463
comment: Creatine kinase octamers associated with the inner mitochondrial membrane catalyze the reaction of creatine and ATP to form phosphocreatine and ADP. Two mitochondrial creatine kinase proteins have been identified, one encoded by CKMT1A and B that is found in many tissues and one encoded by CKMT2 that is found in sarcomeres (Haas et al. 1988; Haas and Straus 1990). Studies of sarcomeric creatine kinase octamers suggest that their organization and association with phospholipids in the inner mitochondrial membrane may facilitate energy transfer from ATP generated in the mitochondrial matrix to cytosolic phosphocreatine (Khuchua et al. 1998; Schlattner et al. 2004).

Evidence241
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10893433
xref: http://identifiers.org/pubmed/9706223
comment: In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter. Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.

2,6-diaminohexanoic acid
type: SmallMoleculeReference
name: Lysine acid
name: L-Lysine [ChEBI:18019]
name: L-Lysine
xref: UnificationXref2410

Evidence239
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16981706
comment: Cytosolic creatine kinase catalyzes the reaction of creatine and ATP to form phosphocreatine and ADP. The active form of the enzyme is a dimer. Monomers of the cytosolic enzyme occur in two isoforms, B and M, so called because of their abundance in brain and muscle respectively. The enzyme is widely expressed in the body and many tissues express both isoforms. Both homo- (BB, MM) and heterodimers (BM) are catalytically active.

Evidence238
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9706223
comment: Carnitine is synthesized in four steps from trimethyllysine (generated in turn by the S-adenosyl-methionine-mediated methylation of lysine residues in proteins, followed by protein hydrolysis). The enzymes that catalyze the first three steps of carnitine synthesis, converting trimethyllysine to gamma-butyrobetaine, are widely distributed in human tissues. The enzyme that catalyzes the last reaction, converting gamma-butyrobetaine to carnitine, is found only in liver and kidney cells, and at very low levels in brain tissues. Other tissues that require carnitine, such as muscle, are dependent on transport systems that mediate its export from the liver and uptake by other tissues (Kerner and Hoppel 1998).

Evidence237
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2925663
xref: http://identifiers.org/pubmed/10702312
comment: Cytosolic 4-trimethylaminobutyraldehyde dehydrogenase tetramer (ALDH9A1) catalyzes the reaction of NAD+', and 4-trimethylammoniobutanal to form 4-Trimethylammoniobutanoate and NADH + H+ (Kurys et al. 1989; Vaz et al. 2000).

Evidence236
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref388
comment: The urea cycle yields urea, the major form in which excess nitrogen is excreted from the human body, and the amino acid arginine (Brusilow and Horwich 2001). It consists of four reactions: that of ornithine and carbamoyl phosphate to form citrulline, of citrulline and aspartate to form argininosuccinate, the cleavage of argininosuccinate to yield fumarate and arginine, and the cleavage of arginine to yield urea and re-form ornithine. The carbamoyl phosphate consumed in this cycle is synthesized in the mitochondria from bicarbonate and ammonia, and this synthesis in turn is dependent on the presence of N-acetylglutamate, which allosterically activates carbamoyl synthetase I enzyme. The synthesis of N-acetylglutamate is stimulated by high levels of arginine. Increased levels of free amino acids, indicated by elevated arginine levels, thus stimulate urea synthesis. Two enzymes catalyze the hydrolysis of arginine to yield ornithine and urea. Cytosolic ARG1 is the canonical urea cycle enzyme. Mitochondrial ARG2 likewise catalyzes urea production from arginine and may have a substantial sparing effect in patients lacking ARG1 enzyme, so its reaction is annotated here although the role of ARG2 under normal physiological conditions remains unclear.

Evidence235
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12859189
xref: http://identifiers.org/pubmed/8898077
xref: http://identifiers.org/pubmed/9686347
comment: Arginase 2 (ARG2) trimer catalyzes the hydrolysis of arginine to form urea and ornithine (Cama et al. 2003). ARG2 is localized to the mitochondrion (Gotoh ea 1996). The enzyme is expressed in many tissues in addition to liver and while its function appears to mitigate the effects of ARG1 deficiency on urea synthesis, its normal physiological roles have not been fully defined (Iyer et al. 1998).

Evidence234
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/7649538
xref: http://identifiers.org/pubmed/16141327
comment: Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).

Evidence233
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2263616
xref: http://identifiers.org/pubmed/9256435
comment: Cytosolic argininosuccinate lyase (ASL) catalyzes the reversible reaction of argininosuccinate to form fumarate and arginine. The enzyme is a homotetramer (Turner et al. 1997). The function of the human enzyme in vivo is inferred from the defective argininosuccinate lyase enzyme activity observed in patients with mutant forms of the ASL gene (e.g., Walker et al. 1990).

Fumaric acid
type: SmallMoleculeReference
name: ChEBI:18012 Fumaric acid
name: Trans-butenedioic acid
xref: UnificationXref844

http://identifiers.org/pubmed/11994049
type: PublicationXref
id: 11994049
author: Aghajanian, S
author: Worrall, DM
db: Pubmed
title: Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)
source: Biochem J 365:13-8
year: 2002

Evidence251
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10524214
xref: http://identifiers.org/pubmed/10484776
comment: Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).

Evidence252
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15956068
comment: Glyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate metabolism, alanine:glyoxylate aminotransferase (AGXT) and glycerate dehydrogenase/glyoxylate reductase (GRHPR), are associated with pathogenic overproduction of oxalate (Danpure 2005). The reactions that interconvert glycine, glycolate, and glyoxylate and convert glyoxylate to oxalate have been characterized in molecular detail in humans. A reaction sequence for the conversion of hydroxyproline to glyoxylate has been inferred from studies of partially purified extracts of rat and bovine liver but the enzymes involved in the corresponding human reactions have not been identified.

Evidence253
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12163696
xref: http://identifiers.org/pubmed/9175157
comment: S-adenosylmethionine (SAM) is an essential metabolite in all cells. SAM is a precursor in the synthesis of polyamines. Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the only known SAM biosynthetic reaction from methionine and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). A third gene MAT2B has been identified and is known to be a part of MAT II heterotetramer complex.

Evidence254
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/18457970
comment: Remethylation of homocysteine to methionine can also happen using betaine as a methyl donor. This reaction is also part of choline catabolism (Li et al. 2008).

http://identifiers.org/pubmed/17555404
type: PublicationXref
id: 17555404
author: Alp, NJ
author: Schmidt, TS
db: Pubmed
title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
source: Clin Sci (Lond) 113:47-63
year: 2007

Evidence250
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/12899834
xref: http://identifiers.org/pubmed/1703535
xref: http://identifiers.org/pubmed/3416563
xref: http://identifiers.org/pubmed/2363689
xref: http://identifiers.org/pubmed/15802217
comment: Alanine-glyoxylate transaminase (AGXT) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Danpure and Jennings 1988). The active form of the enzyme is a homodimer (Zhang et al. 2003) with one molecule of pyridoxal phosphate bound to each subunit (Coulter-Mackie et al. 2005). Mutations in this enzyme are associated with primary hyperoxaluria type I. Mutant alleles encode both catalytically inactive proteins and active ones that are mis-localized to mitochondria (Purdue et al. 1990; Takada et al. 1990).

Evidence249
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10691773
xref: http://identifiers.org/pubmed/3297964
xref: http://identifiers.org/pubmed/16942634
comment: Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan.

Evidence248
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/3297964
comment: Thyroxine (3,5,3',5'-tetraiodothyronine, T4) promotes normal growth and development. It also regulates heat and energy production. T4 is released from the thyroid gland, the largest endocrine organ in the human body. The primary hormone released is T4 although T3 (3,5,3'-triiodothyronine) is also released in small quantities. Tyrosine residues in thyroglobulin (a glycoprotein scaffold containing many tyrosine residues) are iodinated to form mono- or diiodo-tyrosine which can then couple to form either T3 or T4.

NADP+
type: SmallMoleculeReference
name: TPN
name: NADP+ [ChEBI:18009]
name: beta-Nicotinamide adenine dinucleotide phosphate
name: Nicotinamide adenine dinucleotide phosphate
name: Triphosphopyridine nucleotide
name: NADP
xref: UnificationXref11

Evidence245
type: Evidence
evidence code: inferred from electronic annotation
xref: PublicationXref344
comment: L-ornithine is converted into putrescine by ODC holoenzyme complex.Putrescine is subsequent used for polyamine synthesis.

Evidence244
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/15028568
xref: http://identifiers.org/pubmed/17025265
xref: http://identifiers.org/pubmed/15028567
xref: http://identifiers.org/pubmed/15784477
comment: Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator (Reghunathan 2006). Agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation (Satriano, 2003).

3-phenyl-2-oxopropanoate
type: SmallMoleculeReference
name: keto-phenylpyruvate
name: keto-phenylpyruvate [ChEBI:18005]
name: 3-(4-hydroxyphenyl)pyruvate
xref: UnificationXref2276

Evidence247
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/8806637
comment: Iodide (I-) is transported from blood serum into the thyroid cell by the Na+/I- symporter (sodium/iodide). This intrinsic membrane protein uses energy from the inward movement of Na+ to drive the process and accumulate I- in the cell, maintaining a cellular concentration 30-40 times that of the serum concentration. This process, also called the iodide trap, is stimulated by TSH (thyroid stimulating hormone) and is saturable by large amounts of I-.

Evidence246
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11564948
xref: http://identifiers.org/pubmed/12686127
xref: http://identifiers.org/pubmed/15784477
comment: Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

http://identifiers.org/pubmed/9878398
type: PublicationXref
id: 9878398
author: Mirande, M
author: Siatecka, M
author: Robinson, JC
author: Berthonneau, E
author: Quevillon, S
db: Pubmed
title: Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein
source: J Mol Biol 285:183-95
year: 1999

http://identifiers.org/pubmed/14392173
type: PublicationXref
id: 14392173
author: Simms, ES
author: Lieberman, I
author: Kornberg, A
db: Pubmed
title: Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate
source: J Biol Chem 215:389-402
year: 1955

http://identifiers.org/pubmed/15893380
type: PublicationXref
id: 15893380
author: Jackowski, S
author: Zhang, YM
author: Rock, CO
author: Leonardi, R
db: Pubmed
title: Coenzyme A: back in action
source: Prog Lipid Res 44:125-53
year: 2005

http://identifiers.org/pubmed/1737786
type: PublicationXref
id: 1737786
author: Sipila, I
author: Mitchell, GA
author: Fontaine, G
author: Michaud, J
author: Brody, LC
author: Valle, D
author: Steel, G
author: Obie, C
author: Robert, MF
author: Kaiser-Kupfer, M
db: Pubmed
title: Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences.
source: J Biol Chem 267:3302-7
year: 1992

ChEBI:16635 Met-tRNA(Met)
type: SmallMoleculeReference
name: Met-tRNA(Met)
xref: UnificationXref2428

http://identifiers.org/pubmed/9083049
type: PublicationXref
id: 9083049
author: Lee, PT
author: Shepherd, JA
author: Tzagoloff, A
author: Myles, DC
author: Clarke, CF
author: Shtanko, A
author: Barkovich, RJ
db: Pubmed
title: Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
source: J Biol Chem 272:9182-8
year: 1997

http://identifiers.org/pubmed/14730707
type: PublicationXref
id: 14730707
author: Dietrich, J
author: Rao, MS
author: Maragakis, NJ
author: Rothstein, JD
author: Xue, H
author: Wong, V
author: Mayer-Proschel, M
db: Pubmed
title: Glutamate transporter expression and function in human glial progenitors
source: Glia 45:133-43
year: 2004

http://identifiers.org/pubmed/12721358
type: PublicationXref
id: 12721358
author: Veech, RL
db: Pubmed
title: A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis
source: Proc Natl Acad Sci U S A 100:5578-80
year: 2003

UniProt:Q99WZ0
type: ProteinReference
xref: UnificationXref1723
organism: BioSource1

[4Fe-4S](2+)
type: SmallMoleculeReference
name: ChEBI:33722 [4Fe-4S](2+)
xref: UnificationXref1564

ChEBI:16624 Leu-tRNA(Leu)
type: SmallMoleculeReference
name: Leu-tRNA(Leu)
xref: UnificationXref2403

http://identifiers.org/pubmed/21682741
type: PublicationXref
id: 21682741
author: Minnicozzi, M
author: Fenton, MJ
author: Sawyer, RT
db: Pubmed
title: Innate immunity in allergic disease
source: Immunol Rev 242:106-27
year: 2011

http://identifiers.org/pubmed/15520807
type: PublicationXref
id: 15520807
author: Wellbrock, C
author: Karasarides, M
author: Marais, R
db: Pubmed
title: The RAF proteins take centre stage
source: Nat Rev Mol Cell Biol 5:875-85
year: 2004

http://identifiers.org/pubmed/1377680
type: PublicationXref
id: 1377680
author: Kalinowski, SS
author: Bishop, RW
author: Gibson, KM
author: Schafer, BL
author: Tanaka, RD
author: Mosley, ST
author: Kratunis, VJ
db: Pubmed
title: Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria
source: J Biol Chem 267:13229-38
year: 1992

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Reactome
name: L-Glutamic acid
name: L-Glu
name: L-Glutamate
xref: UnificationXref1519
xref: UnificationXref1518
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113552
display name: Glu

Thyroxine biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction158
evidence: Evidence248
xref: UnificationXref1897
xref: UnificationXref1896
xref: RelationshipXref311
pathway order: PathwayStep244
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11752427
type: PublicationXref
id: 11752427
author: McCarthy, DB
author: Stoops, JK
author: O'Connor, CM
author: Reed, LJ
author: Zhou, ZH
db: Pubmed
title: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.
source: Proc Natl Acad Sci U S A 98:14802-7
year: 2001

http://identifiers.org/pubmed/16981706
type: PublicationXref
id: 16981706
author: McLeish, MJ
author: Wang, PF
author: Merz KM, Jr
author: Jensen, JH
author: Cui, G
author: Naor, MM
author: Flynn, AJ
author: Kenyon, GL
db: Pubmed
title: Exploring the role of the active site cysteine in human muscle creatine kinase
source: Biochemistry 45:11464-72
year: 2006

Agmatine biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction155
pathway component: BiochemicalReaction156
evidence: Evidence244
xref: RelationshipXref305
xref: UnificationXref1882
xref: UnificationXref1881
pathway order: PathwayStep239
pathway order: PathwayStep240
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Pantothenate
type: SmallMolecule
entity reference: Pantothenic acid
data source: Reactome
xref: UnificationXref1419
xref: UnificationXref1418
cellular location: extracellular region
comment: Reactome DB_ID: 199192
display name: PanK

Sodium
type: SmallMolecule
entity reference: Na+
data source: Reactome
name: sodium ion
xref: UnificationXref1416
xref: UnificationXref1415
cellular location: extracellular region
comment: Reactome DB_ID: 74113
display name: Na+

xanthosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:10049
data source: Reactome
xref: UnificationXref1407
xref: UnificationXref1408
cellular location: cytosol
comment: Reactome DB_ID: 2509848
display name: XTP

deoxyinosinic acid
type: SmallMolecule
entity reference: 2'-Deoxyinosine 5'-phosphate [ChEBI:28806]
data source: Reactome
name: 2'-deoxyinosine 5'-monophosphate
xref: UnificationXref1402
xref: UnificationXref1401
cellular location: cytosol
comment: Reactome DB_ID: 109330
display name: dIMP

Phosphopantothenoylcysteine
type: SmallMolecule
entity reference: (R)-4'-Phosphopantothenoyl-L-cysteine [ChEBI:328]
data source: Reactome
xref: UnificationXref1440
xref: UnificationXref1441
cellular location: cytosol
comment: Reactome DB_ID: 196834
display name: PPC

http://identifiers.org/pubmed/9593753
type: PublicationXref
id: 9593753
author: Jackowski, S
author: Lykidis, A
author: Murti, KG
db: Pubmed
title: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
source: J Biol Chem 273:14022-9
year: 1998

Phospho-pantothenate
type: SmallMolecule
entity reference: CHEBI:15905
data source: Reactome
xref: UnificationXref1429
xref: UnificationXref1430
cellular location: cytosol
comment: Reactome DB_ID: 196786
display name: PPanK

Sodium
type: SmallMolecule
entity reference: Na+
data source: Reactome
name: sodium ion
xref: UnificationXref1422
xref: UnificationXref1423
cellular location: cytosol
comment: Reactome DB_ID: 83910
display name: Na+

Pantothenate
type: SmallMolecule
entity reference: Pantothenic acid
data source: Reactome
xref: UnificationXref1420
xref: UnificationXref1421
cellular location: cytosol
comment: Reactome DB_ID: 196820
display name: PanK

2'-deoxyinosine 5'-triphosphate
type: SmallMolecule
entity reference: dITP
data source: Reactome
xref: UnificationXref1398
xref: UnificationXref1399
cellular location: cytosol
comment: Reactome DB_ID: 2509835
display name: dITP

2'-deoxyuridine 5'-triphosphate
type: SmallMolecule
entity reference: 2'-deoxyuridine 5'-triphosphate
data source: Reactome
xref: UnificationXref1376
xref: UnificationXref1377
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110694
display name: dUTP

inosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16039
data source: Reactome
xref: UnificationXref1389
xref: UnificationXref1390
cellular location: cytosol
comment: Reactome DB_ID: 2509836
display name: ITP

Zinc efflux and compartmentalization by the SLC30 family
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction237
pathway component: BiochemicalReaction236
pathway component: BiochemicalReaction238
evidence: Evidence383
xref: UnificationXref2797
xref: UnificationXref2798
pathway order: PathwayStep371
pathway order: PathwayStep373
pathway order: PathwayStep372
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Coenzyme R
type: SmallMolecule
entity reference: CHEBI:15956
data source: Reactome
name: D-Biotin
name: Biotin
name: Vitamin H
xref: UnificationXref1463
xref: UnificationXref1464
cellular location: extracellular region
comment: Reactome DB_ID: 199238
display name: Btn

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Reactome
name: Mn(II)
name: Manganese
xref: UnificationXref1471
xref: UnificationXref1472
cellular location: cytosol
comment: Reactome DB_ID: 29418
display name: Mn2+

http://identifiers.org/pubmed/17604717
type: PublicationXref
id: 17604717
author: Manning, BD
author: Cantley, LC
db: Pubmed
title: AKT/PKB signaling: navigating downstream
source: Cell 129:1261-74
year: 2007

Coenzyme R
type: SmallMolecule
entity reference: CHEBI:15956
data source: Reactome
name: D-Biotin
name: Biotin
name: Vitamin H
xref: UnificationXref1465
xref: UnificationXref1466
cellular location: cytosol
comment: Reactome DB_ID: 199207
display name: Btn

Nicotinate D-ribonucleotide
type: SmallMolecule
entity reference: beta-Nicotinate D-ribonucleotide
data source: Reactome
xref: UnificationXref1484
xref: UnificationXref1483
cellular location: cytosol
comment: Reactome DB_ID: 197220

Nicotinate
type: SmallMolecule
entity reference: CHEBI:15940
data source: Reactome
name: Nicotinic acid
name: Niacin
xref: UnificationXref1481
xref: UnificationXref1480
cellular location: cytosol
comment: Reactome DB_ID: 197230
display name: NCA

THF-polyglutamate
type: SmallMolecule
entity reference: THF-polyglutamate
data source: Reactome
xref: UnificationXref1505
xref: UnificationXref1504
cellular location: cytosol
comment: Reactome DB_ID: 197969
display name: THFPG

Folate
type: SmallMolecule
entity reference: Pteroylglutamic acid
data source: Reactome
xref: UnificationXref1496
xref: UnificationXref1497
cellular location: cytosol
comment: Reactome DB_ID: 197965
display name: FOLA

5-methyltetrahydrofolate polyglutamate
type: SmallMolecule
entity reference: CHEBI:63907
data source: Reactome
xref: UnificationXref1515
xref: UnificationXref1514
cellular location: cytosol
comment: Reactome DB_ID: 174404
display name: MTHFPG

5-methyltetrahydrofolate
type: SmallMolecule
entity reference: 5-Methyltetrahydrofolate
data source: Reactome
xref: UnificationXref1511
xref: UnificationXref1512
cellular location: cytosol
comment: Reactome DB_ID: 200665
display name: MTHF

4' phosphopantetheine
type: SmallMolecule
entity reference: Phosphopantetheine
data source: Reactome
xref: UnificationXref1444
xref: UnificationXref1443
cellular location: cytosol
comment: Reactome DB_ID: 196767
display name: PPANT

Dephospho-CoA
type: SmallMolecule
entity reference: Dephospho-CoA
data source: Reactome
xref: UnificationXref1452
xref: UnificationXref1451
cellular location: cytosol
comment: Reactome DB_ID: 196778
display name: DP-CoA

2'-deoxyguanosine 5'-diphosphate
type: SmallMolecule
entity reference: 2'-Deoxyguanosine 5'-diphosphate
data source: Reactome
xref: UnificationXref1353
xref: UnificationXref1352
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110680
display name: dGDP

2'-deoxyadenosine 5'-diphosphate
type: SmallMolecule
entity reference: 2'-deoxyadenosine 5'-diphosphate
data source: Reactome
xref: UnificationXref1351
xref: UnificationXref1350
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110652
display name: dADP

uridine 5'-diphosphate
type: SmallMolecule
entity reference: UDP
data source: Reactome
name: U5DP
xref: UnificationXref1348
xref: UnificationXref1349
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110732
display name: UDP

cytidine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17239
data source: Reactome
xref: UnificationXref1346
xref: UnificationXref1347
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110638
display name: CDP

Guanosine 5'-diphosphate
type: SmallMolecule
entity reference: CHEBI:17552
data source: Reactome
name: Guanosine diphosphate
xref: UnificationXref1344
xref: UnificationXref1345
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113525
display name: GDP

(deoxy)nucleotide diphosphates
type: SmallMolecule
data source: Reactome
member physical entity: 2'-deoxyguanosine 5'-diphosphate
member physical entity: 2'-deoxycytidine 5'-diphosphate
member physical entity: dTDP
member physical entity: Guanosine 5'-diphosphate
member physical entity: 2'-deoxyadenosine 5'-diphosphate
member physical entity: 2'-deoxyuridine 5'-diphosphate
member physical entity: uridine 5'-diphosphate
member physical entity: cytidine 5'-diphosphate
xref: UnificationXref1361
xref: UnificationXref1360
cellular location: mitochondrial matrix
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 482803
display name: (d)NDP

http://identifiers.org/pubmed/8621489
type: PublicationXref
id: 8621489
author: Jenkins, NA
author: Agre, P
author: Bhakta, KY
author: Copeland, NG
author: Griffin, CA
author: Yonescu, R
author: Gilbert, DJ
author: Preston, GM
author: Lee, MD
author: Raina, S
db: Pubmed
title: The human Aquaporin-5 gene. Molecular characterization and chromosomal localization
source: J Biol Chem 271:8599-604
year: 1996

2'-deoxyuridine 5'-triphosphate
type: SmallMolecule
entity reference: 2'-deoxyuridine 5'-triphosphate
data source: Reactome
xref: UnificationXref1333
xref: UnificationXref1334
cellular location: cytosol
comment: Reactome DB_ID: 110685
display name: dUTP

deoxycytidine 5'-triphosphate
type: SmallMolecule
entity reference: deoxycytidine 5'-triphosphate
data source: Reactome
name: Deoxycytidine triphosphate
name: 2'-Deoxycytidine 5'-triphosphate
xref: UnificationXref1328
xref: UnificationXref1327
cellular location: cytosol
comment: Reactome DB_ID: 110660
display name: dCTP

dTTP
type: SmallMolecule
entity reference: TTP
data source: Reactome
name: Deoxythymidine triphosphate
name: deoxythymidine 5'-triphosphate
name: thymidine 5'-triphosphate
xref: UnificationXref1330
xref: UnificationXref1331
cellular location: cytosol
comment: Reactome DB_ID: 110711
display name: TTP

uridine 5'-triphosphate
type: SmallMolecule
entity reference: uridine 5'-triphosphate
data source: Reactome
name: Uridine triphosphate
xref: UnificationXref1322
xref: UnificationXref1321
cellular location: cytosol
comment: Reactome DB_ID: 29494
display name: UTP

2'-deoxyguanosine 5'-triphosphate
type: SmallMolecule
entity reference: 2'-deoxyguanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref1324
xref: UnificationXref1325
cellular location: cytosol
comment: Reactome DB_ID: 110672
display name: dGTP

http://identifiers.org/pubmed/9124315
type: PublicationXref
id: 9124315
author: Huang, MY
author: Young, JD
author: Yao, SY
author: Ritzel, MW
author: Elliott, JF
author: Cass, CE
db: Pubmed
title: Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)
source: Am J Physiol Cell Physiol 272:707-714
year: 1997

2'-deoxyguanosine 5'-triphosphate
type: SmallMolecule
entity reference: 2'-deoxyguanosine 5'-triphosphate
data source: Reactome
xref: UnificationXref1370
xref: UnificationXref1371
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110681
display name: dGTP

2'-deoxyadenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16284
data source: Reactome
xref: UnificationXref1368
xref: UnificationXref1369
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110653
display name: dATP

dTTP
type: SmallMolecule
entity reference: TTP
data source: Reactome
name: deoxythymidine 5'-triphosphate
name: thymidine 5'-triphosphate
xref: UnificationXref1374
xref: UnificationXref1375
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110719
display name: TTP

deoxycytidine 5'-triphosphate
type: SmallMolecule
entity reference: deoxycytidine 5'-triphosphate
data source: Reactome
xref: UnificationXref1373
xref: UnificationXref1372
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110669
display name: dCTP

Guanosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:15996
data source: Reactome
xref: UnificationXref1363
xref: UnificationXref1362
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113573
display name: GTP

uridine 5'-triphosphate
type: SmallMolecule
entity reference: uridine 5'-triphosphate
data source: Reactome
xref: UnificationXref1367
xref: UnificationXref1366
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110731
display name: UTP

cytidine 5'-triphosphate
type: SmallMolecule
entity reference: cytidine 5'-triphosphate
data source: Reactome
xref: UnificationXref1365
xref: UnificationXref1364
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110577
display name: CTP

2'-deoxycytidine 5'-diphosphate
type: SmallMolecule
entity reference: dCDP
data source: Reactome
xref: UnificationXref1354
xref: UnificationXref1355
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110668
display name: dCDP

dTDP
type: SmallMolecule
entity reference: dTDP
data source: Reactome
name: thymidine 5'-diphosphate
name: deoxythymidine 5'-diphosphate
xref: UnificationXref1357
xref: UnificationXref1356
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110720
display name: TDP

2'-deoxyuridine 5'-diphosphate
type: SmallMolecule
entity reference: dUDP [ChEBI:28850]
data source: Reactome
xref: UnificationXref1359
xref: UnificationXref1358
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 110693
display name: dUDP

(deoxy)nucleotide diphosphates
type: SmallMolecule
data source: Reactome
member physical entity: deoxycytidine 5'-triphosphate
member physical entity: Guanosine 5'-triphosphate
member physical entity: dTTP
member physical entity: 2'-deoxyadenosine 5'-triphosphate
member physical entity: cytidine 5'-triphosphate
member physical entity: 2'-deoxyuridine 5'-triphosphate
member physical entity: uridine 5'-triphosphate
member physical entity: 2'-deoxyguanosine 5'-triphosphate
xref: UnificationXref1378
xref: UnificationXref1379
cellular location: mitochondrial matrix
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 482807
display name: (d)NTP

http://identifiers.org/pubmed/10684970
type: PublicationXref
id: 10684970
author: Cai, YC
author: Bullard, JM
author: Spremulli, LL
db: Pubmed
title: Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
source: Biochim Biophys Acta 1490:245-58
year: 2000

plasma membrane
type: CellularLocationVocabulary
xref: UnificationXref509

http://identifiers.org/pubmed/15157936
type: PublicationXref
id: 15157936
author: Bertinato, J
author: L'Abbé, MR
db: Pubmed
title: Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiency or overload
source: J Nutr Biochem 15:316-22
year: 2004

http://identifiers.org/pubmed/20147624
type: PublicationXref
id: 20147624
author: Pellegrini-Calace, M
author: Oliva, R
author: Calamita, G
author: Thornton, JM
db: Pubmed
title: Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
source: Proc Natl Acad Sci U S A 107:4135-40
year: 2010

Uroporphyrinogen I
type: SmallMoleculeReference
name: Uroporphyrinogen I [ChEBI:9904]
xref: UnificationXref2012

Abacavir metabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction182
pathway component: BiochemicalReaction183
evidence: Evidence296
xref: RelationshipXref362
xref: UnificationXref2228
xref: UnificationXref2229
pathway order: PathwayStep291
pathway order: PathwayStep290
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/19675644
type: PublicationXref
id: 19675644
author: Ribbe, MW
author: Mendel, RR
author: Schwarz, G
db: Pubmed
title: Molybdenum cofactors, enzymes and pathways
source: Nature 460:839-47
year: 2009

http://identifiers.org/pubmed/7273846
type: PublicationXref
id: 7273846
author: Cori, CF
db: Pubmed
title: The glucose-lactic acid cycle and gluconeogenesis
source: Curr Top Cell Regul 18:377-87
year: 1981

http://identifiers.org/pubmed/6451249
type: PublicationXref
id: 6451249
author: Vora, S
db: Pubmed
title: Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system
source: Blood 57:724-32
year: 1981

Metabolism of folate and pterines
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction125
pathway component: BiochemicalReaction121
pathway component: BiochemicalReaction126
pathway component: BiochemicalReaction124
pathway component: BiochemicalReaction122
pathway component: BiochemicalReaction117
pathway component: BiochemicalReaction123
pathway component: BiochemicalReaction118
pathway component: BiochemicalReaction120
pathway component: BiochemicalReaction119
evidence: Evidence199
xref: RelationshipXref240
xref: UnificationXref1552
xref: UnificationXref1551
pathway order: PathwayStep186
pathway order: PathwayStep194
pathway order: PathwayStep193
pathway order: PathwayStep192
pathway order: PathwayStep190
pathway order: PathwayStep187
pathway order: PathwayStep188
pathway order: PathwayStep189
pathway order: PathwayStep191
pathway order: PathwayStep195
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10702312
type: PublicationXref
id: 10702312
author: Vaz, FM
author: Ofman, R
author: Fouchier, SW
author: Sommer, M
db: Pubmed
title: Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.
source: J Biol Chem 275:7390-4
year: 2000

http://identifiers.org/pubmed/14977861
type: PublicationXref
id: 14977861
author: Chowdhury, JR
author: Wells, PG
author: Kim, PM
author: Hansen, AJ
author: Ishii, Y
author: Gregory, PA
author: Mackenzie, PI
author: Chowdhury, NR
author: Ritter, JK
author: Kessler, FK
author: Guillemette, C
db: Pubmed
title: Glucuronidation and the UDP-glucuronosyltransferases in health and disease
source: Drug Metab Dispos 32:281-90
year: 2004

http://identifiers.org/pubmed/21768372
type: PublicationXref
id: 21768372
author: Murtaugh, L Charles
author: Barrow, Jeffery R
author: Cash, Gabriela M
author: Smith, Aaron P
author: Barrott, Jared J
db: Pubmed
title: Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
source: Proc. Natl. Acad. Sci. U.S.A. 108:12752-7
year: 2011

Phenyllactate [ChEBI:8100]
type: SmallMoleculeReference
name: Phenyllactate
xref: UnificationXref2279

http://identifiers.org/pubmed/9488696
type: PublicationXref
id: 9488696
author: Geeves, MA
author: Konrad, M
author: Schaertl, S
db: Pubmed
title: Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis
source: J Biol Chem 273:5662-5669
year: 1998

Cytidine 5'-diphosphocholine
type: SmallMoleculeReference
name: CDPcholine
name: CDPcholine [ChEBI:3268]
xref: UnificationXref519

Arachidonic acid metabolism
type: Pathway
data source: Reactome
pathway component: REACT 158726.3
pathway component: REACT 154872.3
pathway component: REACT 155948.3
pathway component: Synthesis of 5-eicosatetraenoic acids
pathway component: REACT 154984.3
pathway component: REACT 156460.3
evidence: Evidence88
xref: RelationshipXref100
xref: UnificationXref660
xref: UnificationXref659
pathway order: PathwayStep75
pathway order: PathwayStep77
pathway order: PathwayStep79
pathway order: PathwayStep73
pathway order: PathwayStep84
pathway order: PathwayStep82
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

G1/S Transition
type: Pathway
data source: Reactome
pathway component: E2F mediated regulation of DNA replication
pathway component: REACT 133418.5
evidence: Evidence443
xref: UnificationXref3038
xref: UnificationXref3037
xref: RelationshipXref505
pathway order: PathwayStep427
pathway order: PathwayStep428
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Synthesis of PE
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction35
evidence: Evidence65
xref: UnificationXref499
xref: UnificationXref498
xref: RelationshipXref73
pathway order: PathwayStep61
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Blood coagulation
type: Pathway
data source: Reactome
pathway component: Platelet homeostasis
evidence: Evidence4
xref: RelationshipXref3
xref: UnificationXref35
xref: UnificationXref34
pathway order: PathwayStep3
display name: Hemostasis
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7685356
type: PublicationXref
id: 7685356
author: Weiner, KX
author: Maley, F
author: Weiner, RS
author: Maley, GF
db: Pubmed
title: Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli
source: J Biol Chem 268:12983-9
year: 1993

2'-Deoxyuridine
type: SmallMoleculeReference
name: 2-Deoxyuridine
name: Deoxyuridine
name: Deoxyuridine [ChEBI:16450]
xref: UnificationXref1210

(S)-2-Amino-5-guanidinovaleric acid
type: SmallMoleculeReference
name: L-Arginine
name: L-Arginine [ChEBI:16467]
xref: UnificationXref2

cytosol
type: CellularLocationVocabulary
xref: UnificationXref1

http://identifiers.org/pubmed/11261429
type: PublicationXref
id: 11261429
author: Elsas, LJ
author: Lai, K
db: Pubmed
title: The molecular biology of galactosemia.
source: Genet Med 1:40-8
year: 2001

NADPH
type: SmallMoleculeReference
name: NADPH [ChEBI:16474]
name: TPNH
xref: UnificationXref8

Synthesis of substrates in N-glycan biosythesis
type: Pathway
data source: Reactome
pathway component: Synthesis of UDP-N-acetyl-glucosamine
evidence: Evidence422
xref: UnificationXref2989
xref: UnificationXref2988
pathway order: PathwayStep411
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/2168892
type: PublicationXref
id: 2168892
author: Tatibana, M
author: Shimizu, N
author: Shimada, H
author: Iizasa, T
author: Kudoh, J
author: Taira, M
db: Pubmed
title: A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon
source: J Biol Chem 265:16491-16497
year: 1990

http://identifiers.org/pubmed/1896471
type: PublicationXref
id: 1896471
author: Hirono, A
author: Fujii, H
author: Kanno, H
author: Miwa, S
db: Pubmed
title: cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia
source: Proc Natl Acad Sci U S A 88:8218-21
year: 1991

http://identifiers.org/pubmed/9806845
type: PublicationXref
id: 9806845
author: Inase, N
author: Ishibashi, K
author: Ichioka, M
author: Marumo, F
author: Koyama, N
author: Sasaki, S
author: Kuwahara, M
db: Pubmed
title: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene
source: Genomics 54:169-72
year: 1998

RelationshipXref480
type: RelationshipXref
id: GO:0043682
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref481
type: RelationshipXref
id: 4231037
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231037

Nitrogen monoxide
type: SmallMoleculeReference
name: Nitric oxide [ChEBI:7583]
name: Nitric oxide
name: NO
xref: UnificationXref17

http://identifiers.org/pubmed/7350913
type: PublicationXref
id: 7350913
author: Lombardo, D
author: Guy, O
db: Pubmed
title: Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters.
source: Biochim Biophys Acta 611:147-55
year: 1980

http://identifiers.org/pubmed/7350912
type: PublicationXref
id: 7350912
author: Lombardo, D
author: Fauvel, J
author: Guy, O
db: Pubmed
title: Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. I. Action on carboxyl esters, glycerides and phospholipids.
source: Biochim Biophys Acta 611:136-46
year: 1980

RelationshipXref479
type: RelationshipXref
id: 4231034
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231034

http://identifiers.org/pubmed/2332429
type: PublicationXref
id: 2332429
author: Vance, JE
db: Pubmed
title: Phospholipid synthesis in a membrane fraction associated with mitochondria
source: J Biol Chem 265:7248-56
year: 1990

RelationshipXref472
type: RelationshipXref
id: GO:0006833
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref471
type: RelationshipXref
id: 4231003
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231003

RelationshipXref474
type: RelationshipXref
id: 4230885
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230885

ChEBI:15355 O-acetylcholine
type: SmallMoleculeReference
name: O-acetylcholine
xref: UnificationXref500

RelationshipXref473
type: RelationshipXref
id: 4230945
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230945

Choline
type: SmallMoleculeReference
name: ChEBI:15354 Choline
xref: UnificationXref503

RelationshipXref476
type: RelationshipXref
id: GO:0015793
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref475
type: RelationshipXref
id: 4230881
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230881

RelationshipXref478
type: RelationshipXref
id: GO:0004008
db: GENE ONTOLOGY
relationship type: MI:0355

Acetyl coenzyme A
type: SmallMoleculeReference
name: Acetyl-CoA
name: Acetyl-CoA [ChEBI:15351]
xref: UnificationXref166

RelationshipXref477
type: RelationshipXref
id: GO:0006879
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref470
type: RelationshipXref
id: GO:0015265
db: GENE ONTOLOGY
relationship type: MI:0355

Lipoate
type: SmallMoleculeReference
name: Thioctic acid
name: Lipoate [ChEBI:6492]
name: alpha-Lipoic acid
name: Lipoic acid
xref: UnificationXref2820

RelationshipXref469
type: RelationshipXref
id: 4230998
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230998

RelationshipXref468
type: RelationshipXref
id: GO:0015254
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref463
type: RelationshipXref
id: 4230293
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230293

Acetate [ChEBI:15366]
type: SmallMoleculeReference
name: Acetate
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref2082

RelationshipXref462
type: RelationshipXref
id: 4230287
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230287

RelationshipXref461
type: RelationshipXref
id: GO:0005415
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref460
type: RelationshipXref
id: 4230941
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230941

2'-deoxyguanosine 5'-triphosphate
type: SmallMoleculeReference
name: dGTP [ChEBI:16497]
name: dGTP
name: Deoxyguanosine 5'-triphosphate
name: Deoxyguanosine triphosphate
xref: UnificationXref1323

RelationshipXref467
type: RelationshipXref
id: 4230996
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230996

http://identifiers.org/pubmed/9466989
type: PublicationXref
id: 9466989
author: Leroux, J
author: Degoul, F
author: Helm, M
author: Brule, H
author: Cepanec, C
author: Florentz, C
author: Giege, R
author: Marsac, C
db: Pubmed
title: Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene
source: Hum Mol Genet 7:347-54
year: 1998

RelationshipXref466
type: RelationshipXref
id: GO:0015250
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref465
type: RelationshipXref
id: GO:0055085
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref464
type: RelationshipXref
id: 4230299
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230299

UnificationXref416
type: UnificationXref
id: REACT_10138
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10138.1

UnificationXref417
type: UnificationXref
id: CHEBI:52977
db: ChEBI

UnificationXref418
type: UnificationXref
id: 390241
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390241

UnificationXref419
type: UnificationXref
id: REACT_17480
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17480.1

UnificationXref412
type: UnificationXref
id: 4231290
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231290

UnificationXref413
type: UnificationXref
id: REACT_86890
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86890.9

UnificationXref414
type: UnificationXref
id: GO:0005782
db: GENE ONTOLOGY

UnificationXref415
type: UnificationXref
id: 193514
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193514

5,6,7,8-Tetrahydrobiopterin
type: SmallMoleculeReference
name: 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone
name: Tetrahydrobiopterin
name: Tetrahydrobiopterin [ChEBI:15372]
xref: UnificationXref744

RelationshipXref458
type: RelationshipXref
id: 4230934
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230934

RelationshipXref457
type: RelationshipXref
id: 4230929
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230929

RelationshipXref459
type: RelationshipXref
id: GO:0015204
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref454
type: RelationshipXref
id: 4230915
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230915

7,8-Dihydrobiopterin
type: SmallMoleculeReference
name: 7,8-Dihydrobiopterin [ChEBI:2250]
xref: UnificationXref752

RelationshipXref453
type: RelationshipXref
id: GO:0005381
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref456
type: RelationshipXref
id: 4230924
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230924

UnificationXref411
type: UnificationXref
id: REACT_130678
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_130678.5

RelationshipXref455
type: RelationshipXref
id: GO:0005385
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref410
type: UnificationXref
id: 4231426
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231426

RelationshipXref450
type: RelationshipXref
id: 4230898
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230898

Oxygen
type: SmallMoleculeReference
name: O2
name: Oxygen [ChEBI:15379]
xref: UnificationXref5

H+ [ChEBI:15378]
type: SmallMoleculeReference
name: H+
xref: UnificationXref239

RelationshipXref452
type: RelationshipXref
id: 4230901
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230901

H2O
type: SmallMoleculeReference
name: Water
name: H2O [ChEBI:15377]
xref: UnificationXref133

RelationshipXref451
type: RelationshipXref
id: GO:0015137
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref407
type: UnificationXref
id: REACT_146049
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146049.5

UnificationXref408
type: UnificationXref
id: 4231425
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231425

UnificationXref405
type: UnificationXref
id: REACT_100249
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_100249.9

Salicylate-CoA
type: SmallMoleculeReference
name: Salicylate-CoA [ChEBI:32587]
name: salicoyl-coenzyme A
name: 2-hydroxybenzoyl-CoA
xref: UnificationXref2197

UnificationXref406
type: UnificationXref
id: 4231153
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231153

UnificationXref403
type: UnificationXref
id: 4230450
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230450

UnificationXref404
type: UnificationXref
id: 4230452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230452

UnificationXref401
type: UnificationXref
id: REACT_18250
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18250.2

UnificationXref402
type: UnificationXref
id: Q7A5V7
db: UniProt

UnificationXref409
type: UnificationXref
id: REACT_136127
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136127.5

http://identifiers.org/pubmed/11034202
type: PublicationXref
id: 11034202
author: Agre, P
author: Walz, T
author: Engel, A
author: Heymann, JB
author: Hirai, T
author: Murata, K
author: Fujiyoshi, Y
author: Mitsuoka, K
db: Pubmed
title: Structural determinants of water permeation through aquaporin-1
source: Nature 407:599-605
year: 2000

RelationshipXref449
type: RelationshipXref
id: GO:0015362
db: GENE ONTOLOGY
relationship type: MI:0355

Succinyl-CoA
type: SmallMoleculeReference
name: Succinyl-CoA [ChEBI:15380]
name: Succinyl coenzyme A
xref: UnificationXref820

RelationshipXref448
type: RelationshipXref
id: 4230907
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230907

RelationshipXref90
type: RelationshipXref
id: GO:0097257
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref447
type: RelationshipXref
id: GO:0015361
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref91
type: RelationshipXref
id: 4231163
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231163

RelationshipXref446
type: RelationshipXref
id: 4230895
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230895

RelationshipXref92
type: RelationshipXref
id: GO:0006691
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref445
type: RelationshipXref
id: 4230904
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230904

RelationshipXref93
type: RelationshipXref
id: GO:0004602
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref400
type: UnificationXref
id: 188451
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188451

RelationshipXref444
type: RelationshipXref
id: GO:0015382
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref94
type: RelationshipXref
id: 4231185
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231185

RelationshipXref443
type: RelationshipXref
id: 4230890
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230890

RelationshipXref95
type: RelationshipXref
id: GO:0019372
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/4328836
type: PublicationXref
id: 4328836
author: Kelley, WN
author: Fox, IH
db: Pubmed
title: Human phosphoribosylpyrophosphate synthetase
source: J Biol Chem 246:5739-5748
year: 1971

RelationshipXref442
type: RelationshipXref
id: GO:0008508
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref96
type: RelationshipXref
id: 4231180
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231180

early endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref2529

RelationshipXref441
type: RelationshipXref
id: GO:0006811
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref97
type: RelationshipXref
id: GO:0036185
db: GENE ONTOLOGY
relationship type: MI:0355

late endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref2553

RelationshipXref440
type: RelationshipXref
id: 4230870
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230870

RelationshipXref98
type: RelationshipXref
id: 4231182
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231182

RelationshipXref99
type: RelationshipXref
id: GO:2001300
db: GENE ONTOLOGY
relationship type: MI:0359

endosome lumen
type: CellularLocationVocabulary
xref: UnificationXref2772

UnificationXref435
type: UnificationXref
id: 191374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191374

UnificationXref434
type: UnificationXref
id: REACT_9741
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9741.2

UnificationXref437
type: UnificationXref
id: 76194
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76194

UnificationXref436
type: UnificationXref
id: REACT_9666
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9666.2

UnificationXref439
type: UnificationXref
id: 4230488
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230488

UnificationXref438
type: UnificationXref
id: REACT_2732
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2732.2

RelationshipXref89
type: RelationshipXref
id: GO:0019371
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref88
type: RelationshipXref
id: 4231170
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231170

RelationshipXref87
type: RelationshipXref
id: GO:0036132
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref86
type: RelationshipXref
id: 4231168
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231168

RelationshipXref85
type: RelationshipXref
id: GO:0050221
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref430
type: UnificationXref
id: REACT_92459
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_92459.9

UnificationXref431
type: UnificationXref
id: 4231366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231366

RelationshipXref84
type: RelationshipXref
id: GO:0033559
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref432
type: UnificationXref
id: REACT_87163
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87163.9

RelationshipXref83
type: RelationshipXref
id: GO:0036109
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/4684686
type: PublicationXref
id: 4684686
author: Uchino, H
author: Ito, K
db: Pubmed
title: Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification
source: J Biol Chem 248:389-392
year: 1973

UnificationXref433
type: UnificationXref
id: 191293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191293

RelationshipXref82
type: RelationshipXref
id: 4231154
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231154

RelationshipXref81
type: RelationshipXref
id: GO:0008775
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref80
type: RelationshipXref
id: GO:0006644
db: GENE ONTOLOGY
relationship type: MI:0359

UniProt:P65636
type: ProteinReference
xref: UnificationXref1654
organism: BioSource1

UnificationXref426
type: UnificationXref
id: 4230775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230775

UnificationXref425
type: UnificationXref
id: Q7A7X1
db: UniProt

UnificationXref424
type: UnificationXref
id: REACT_17646
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17646.1

UnificationXref423
type: UnificationXref
id: 390246
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390246

RelationshipXref79
type: RelationshipXref
id: GO:0046474
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref429
type: UnificationXref
id: 4231365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231365

UnificationXref428
type: UnificationXref
id: REACT_99914
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_99914.9

UnificationXref427
type: UnificationXref
id: 4230777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230777

RelationshipXref76
type: RelationshipXref
id: GO:0004105
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref75
type: RelationshipXref
id: 4230666
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230666

RelationshipXref78
type: RelationshipXref
id: GO:0006656
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref77
type: RelationshipXref
id: 4231119
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231119

UnificationXref421
type: UnificationXref
id: REACT_17437
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17437.2

RelationshipXref72
type: RelationshipXref
id: 4231123
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231123

UnificationXref422
type: UnificationXref
id: CHEBI:52974
db: ChEBI

RelationshipXref71
type: RelationshipXref
id: GO:0004306
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref74
type: RelationshipXref
id: GO:0003990
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref420
type: UnificationXref
id: 353123
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=353123

RelationshipXref73
type: RelationshipXref
id: GO:0006646
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref70
type: RelationshipXref
id: GO:0008202
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/18321209
type: PublicationXref
id: 18321209
author: Jansen, T
author: Daiber, A
author: Schulz, E
author: Wenzel, P
author: Münzel, T
db: Pubmed
title: Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
source: Antioxid Redox Signal 10:1115-26
year: 2008

Ubiquinol biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction49
pathway component: BiochemicalReaction48
evidence: Evidence94
xref: UnificationXref713
xref: UnificationXref712
xref: RelationshipXref109
pathway order: PathwayStep89
pathway order: PathwayStep90
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10485994
type: PublicationXref
id: 10485994
author: Kamath, SG
author: Smith, CH
author: Way, BA
author: Furesz, TC
db: Pubmed
title: Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1
source: J Membr Biol 171:55-62
year: 1999

RelationshipXref68
type: RelationshipXref
id: 4230517
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230517

RelationshipXref69
type: RelationshipXref
id: GO:0006704
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref457
type: UnificationXref
id: 191362
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191362

UnificationXref456
type: UnificationXref
id: CHEBI:16584
db: ChEBI

UnificationXref459
type: UnificationXref
id: Q7A756
db: UniProt

UnificationXref458
type: UnificationXref
id: REACT_9725
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9725.2

RelationshipXref497
type: RelationshipXref
id: GO:0030968
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref63
type: RelationshipXref
id: 4230495
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230495

UnificationXref452
type: UnificationXref
id: REACT_80823
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80823.9

RelationshipXref498
type: RelationshipXref
id: GO:0044267
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref62
type: RelationshipXref
id: GO:0004496
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref453
type: UnificationXref
id: CHEBI:15899
db: ChEBI

RelationshipXref499
type: RelationshipXref
id: GO:0015433
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref61
type: RelationshipXref
id: 4230489
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230489

UnificationXref454
type: UnificationXref
id: 191403
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191403

RelationshipXref60
type: RelationshipXref
id: GO:0033540
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref455
type: UnificationXref
id: REACT_9758
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9758.2

RelationshipXref493
type: RelationshipXref
id: GO:0006488
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref67
type: RelationshipXref
id: GO:0003845
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref494
type: RelationshipXref
id: GO:0018279
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref66
type: RelationshipXref
id: GO:0006695
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref495
type: RelationshipXref
id: GO:0043687
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref450
type: UnificationXref
id: 4230494
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230494

RelationshipXref65
type: RelationshipXref
id: 4230501
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230501

RelationshipXref496
type: RelationshipXref
id: GO:0006987
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref451
type: UnificationXref
id: 4230496
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230496

RelationshipXref64
type: RelationshipXref
id: GO:0004163
db: GENE ONTOLOGY
relationship type: MI:0355

Reactome
type: Provenance
comment: http://www.reactome.org

half cystine
type: SequenceModificationVocabulary
xref: UnificationXref1956

RelationshipXref492
type: RelationshipXref
id: GO:0006048
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref57
type: RelationshipXref
id: GO:0044255
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref491
type: RelationshipXref
id: 4230952
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230952

RelationshipXref58
type: RelationshipXref
id: GO:0003988
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref490
type: RelationshipXref
id: GO:0003977
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref59
type: RelationshipXref
id: 4230776
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230776

UnificationXref449
type: UnificationXref
id: 4230493
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230493

UnificationXref448
type: UnificationXref
id: Q7A757
db: UniProt

UnificationXref447
type: UnificationXref
id: REACT_9694
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9694.2

UnificationXref446
type: UnificationXref
id: 191296
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191296

UnificationXref445
type: UnificationXref
id: CHEBI:17436
db: ChEBI

RelationshipXref488
type: RelationshipXref
id: GO:0004360
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref50
type: RelationshipXref
id: GO:0019432
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref443
type: UnificationXref
id: 191424
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191424

RelationshipXref489
type: RelationshipXref
id: 4230959
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230959

UnificationXref444
type: UnificationXref
id: REACT_9551
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9551.2

RelationshipXref486
type: RelationshipXref
id: 4231236
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231236

RelationshipXref52
type: RelationshipXref
id: 4230226
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230226

UnificationXref441
type: UnificationXref
id: REACT_91924
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_91924.9

Ethanal
type: SmallMoleculeReference
name: Acetaldehyde
name: Acetaldehyde [ChEBI:15343]
xref: UnificationXref2067

RelationshipXref487
type: RelationshipXref
id: 4231233
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231233

RelationshipXref51
type: RelationshipXref
id: GO:0004421
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref442
type: UnificationXref
id: CHEBI:17710
db: ChEBI

RelationshipXref484
type: RelationshipXref
id: 4231239
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231239

RelationshipXref54
type: RelationshipXref
id: GO:0046950
db: GENE ONTOLOGY
relationship type: MI:0359

Acetoacetyl coenzyme A
type: SmallMoleculeReference
name: Acetoacetyl-CoA
name: 3-Acetoacetyl-CoA
name: Acetoacetyl-CoA [ChEBI:15345]
xref: UnificationXref375

RelationshipXref485
type: RelationshipXref
id: GO:0015143
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref53
type: RelationshipXref
id: GO:0046951
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref440
type: UnificationXref
id: 4230490
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230490

CoA-SH
type: SmallMoleculeReference
name: Coenzyme A
name: CoA
name: CoA [ChEBI:15346]
xref: UnificationXref378

RelationshipXref482
type: RelationshipXref
id: GO:0034220
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref56
type: RelationshipXref
id: 4230451
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230451

RelationshipXref483
type: RelationshipXref
id: GO:0005436
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref55
type: RelationshipXref
id: GO:0004368
db: GENE ONTOLOGY
relationship type: MI:0355

UniProt:P63831
type: ProteinReference
xref: UnificationXref1453
organism: BioSource1

UniProt:P65602
type: ProteinReference
xref: UnificationXref1795
organism: BioSource1

RelationshipXref506
type: RelationshipXref
id: GO:0000278
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref505
type: RelationshipXref
id: GO:0000082
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref508
type: RelationshipXref
id: GO:0019104
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref507
type: RelationshipXref
id: GO:0045007
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref502
type: RelationshipXref
id: GO:0042590
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref501
type: RelationshipXref
id: GO:0002479
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref504
type: RelationshipXref
id: GO:0000083
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref503
type: RelationshipXref
id: GO:0002474
db: GENE ONTOLOGY
relationship type: MI:0359

cupric ion
type: SmallMoleculeReference
name: Cu(II)
name: copper(2+) [ChEBI:29036]
name: copper(2+)
name: COPPER (II) ION
name: copper(II) cation
name: copper, ion (Cu2+)
name: Cu2+
name: Cu(2+)
xref: UnificationXref2917

UnificationXref343
type: UnificationXref
id: REACT_157604
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157604.3

RelationshipXref30
type: RelationshipXref
id: 4229764
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229764

UnificationXref342
type: UnificationXref
id: 4230509
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230509

RelationshipXref500
type: RelationshipXref
id: 4231091
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231091

UnificationXref345
type: UnificationXref
id: 192457
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192457

UnificationXref344
type: UnificationXref
id: CHEBI:17389
db: ChEBI

RelationshipXref33
type: RelationshipXref
id: GO:0004750
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11115402
type: PublicationXref
id: 11115402
author: Sutherland, M
author: Nigam, S
author: Shankaranarayanan, P
author: Schewe, T
db: Pubmed
title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism
source: Biochem J 353:91-100
year: 2001

RelationshipXref34
type: RelationshipXref
id: 4230013
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230013

RelationshipXref31
type: RelationshipXref
id: GO:0004616
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref341
type: UnificationXref
id: 4230507
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230507

RelationshipXref32
type: RelationshipXref
id: 4230007
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230007

UnificationXref340
type: UnificationXref
id: 4230506
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230506

RelationshipXref38
type: RelationshipXref
id: GO:0004749
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/20171863
type: PublicationXref
id: 20171863
author: Savina, A
author: Amigorena, S
db: Pubmed
title: Intracellular mechanisms of antigen cross presentation in dendritic cells
source: Curr Opin Immunol 22:109-17
year: 2010

RelationshipXref37
type: RelationshipXref
id: GO:0006098
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref36
type: RelationshipXref
id: 4230018
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230018

http://identifiers.org/pubmed/8340364
type: PublicationXref
id: 8340364
author: Fremeau RT, Jr
author: McNamara, JO
author: Tamarappoo, BK
author: Shafqat, S
author: Guadaño-Ferraz, A
author: Puranam, RS
author: Kilberg, MS
db: Pubmed
title: Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters
source: J Biol Chem 268:15351-5
year: 1993

RelationshipXref35
type: RelationshipXref
id: GO:0004751
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref346
type: UnificationXref
id: REACT_9663
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9663.3

UnificationXref347
type: UnificationXref
id: CHEBI:17754
db: ChEBI

UnificationXref348
type: UnificationXref
id: 192438
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192438

RelationshipXref39
type: RelationshipXref
id: 4230363
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230363

UnificationXref349
type: UnificationXref
id: REACT_9588
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9588.2

RelationshipXref509
type: RelationshipXref
id: 4230356
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230356

RelationshipXref519
type: RelationshipXref
id: GO:0006281
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref518
type: RelationshipXref
id: GO:0006307
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref517
type: RelationshipXref
id: 4230221
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230221

RelationshipXref516
type: RelationshipXref
id: GO:0003908
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref515
type: RelationshipXref
id: GO:0006284
db: GENE ONTOLOGY
relationship type: MI:0359

2-Amino-3-carboxymuconate semialdehyde [ChEBI:29044]
type: SmallMoleculeReference
name: 2-Amino-3-carboxymuconate semialdehyde
xref: UnificationXref1754

RelationshipXref514
type: RelationshipXref
id: GO:0006285
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref513
type: RelationshipXref
id: 4230331
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230331

RelationshipXref512
type: RelationshipXref
id: GO:0000703
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref511
type: RelationshipXref
id: GO:0045008
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref356
type: UnificationXref
id: 174675
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174675

RelationshipXref510
type: RelationshipXref
id: 4230359
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230359

UnificationXref355
type: UnificationXref
id: CHEBI:18035
db: ChEBI

RelationshipXref40
type: RelationshipXref
id: 4230114
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230114

UnificationXref354
type: UnificationXref
id: REACT_7394
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7394.2

RelationshipXref41
type: RelationshipXref
id: GO:0006015
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref353
type: UnificationXref
id: 171126
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171126

RelationshipXref42
type: RelationshipXref
id: GO:0005975
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref352
type: UnificationXref
id: CHEBI:17855
db: ChEBI

RelationshipXref43
type: RelationshipXref
id: GO:0004771
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref351
type: UnificationXref
id: REACT_154250
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154250.3

RelationshipXref44
type: RelationshipXref
id: 4230508
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230508

UnificationXref350
type: UnificationXref
id: 4230511
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230511

http://identifiers.org/pubmed/8117307
type: PublicationXref
id: 8117307
author: Sakura, H
author: Kadowaki, T
author: Moriuchi, R
author: Yasuda, K
author: Nagataki, S
author: Kawasaki, E
author: Yazaki, Y
author: Hayakawa, T
author: Eto, K
db: Pubmed
title: Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet.
source: Biochem Biophys Res Commun 198:990-8
year: 1994

RelationshipXref45
type: RelationshipXref
id: GO:0047372
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref47
type: RelationshipXref
id: GO:0044241
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref46
type: RelationshipXref
id: 4230510
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230510

RelationshipXref49
type: RelationshipXref
id: 4230250
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230250

http://identifiers.org/pubmed/16511037
type: PublicationXref
id: 16511037
author: Kinoshita, T
author: Nishimura, S
author: Nakajima, H
author: Maruki, R
author: Warizaya, M
db: Pubmed
title: Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method
source: Acta Crystallogr Sect F Struct Biol Cryst Commun 61:346-9
year: 2005

RelationshipXref48
type: RelationshipXref
id: GO:0004370
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref359
type: UnificationXref
id: REACT_157103
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157103.3

UnificationXref357
type: UnificationXref
id: REACT_7775
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7775.3

UnificationXref358
type: UnificationXref
id: 4230512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230512

UniProt:Q99VV7
type: ProteinReference
xref: UnificationXref2576
organism: BioSource1

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
name: (2R)-2-Hydroxy-3-(phosphonooxy)-propanal [ChEBI:29052]
name: (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
xref: UnificationXref108

RelationshipXref11
type: RelationshipXref
id: GO:0004807
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref361
type: UnificationXref
id: REACT_154910
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154910.3

RelationshipXref12
type: RelationshipXref
id: 4229770
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229770

UnificationXref360
type: UnificationXref
id: 4231323
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231323

Adenosine 5'-triphosphate
type: SmallMoleculeReference
name: ATP
name: ATP [ChEBI:15422]
xref: UnificationXref58

UnificationXref363
type: UnificationXref
id: REACT_154782
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_154782.3

RelationshipXref10
type: RelationshipXref
id: 4229782
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229782

UnificationXref362
type: UnificationXref
id: 4231324
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231324

UnificationXref365
type: UnificationXref
id: REACT_3756
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3756.1

UnificationXref364
type: UnificationXref
id: 76116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76116

UnificationXref367
type: UnificationXref
id: 76114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76114

UnificationXref366
type: UnificationXref
id: CHEBI:15978
db: ChEBI

UnificationXref368
type: UnificationXref
id: REACT_4327
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4327.2

RelationshipXref19
type: RelationshipXref
id: GO:0006096
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref369
type: UnificationXref
id: P99113
db: UniProt

RelationshipXref18
type: RelationshipXref
id: 4230029
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230029

RelationshipXref17
type: RelationshipXref
id: GO:0004743
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref16
type: RelationshipXref
id: 4229807
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229807

Gly
type: SmallMoleculeReference
name: Glycine
name: Glycine [ChEBI:15428]
name: Aminoacetic acid
xref: UnificationXref917

RelationshipXref15
type: RelationshipXref
id: GO:0004634
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref14
type: RelationshipXref
id: 4229801
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229801

RelationshipXref13
type: RelationshipXref
id: GO:0004618
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref370
type: UnificationXref
id: 4230249
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230249

RelationshipXref20
type: RelationshipXref
id: GO:0004736
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref374
type: UnificationXref
id: REACT_149967
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_149967.4

RelationshipXref21
type: RelationshipXref
id: 4229813
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229813

UnificationXref373
type: UnificationXref
id: 4231293
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231293

RelationshipXref22
type: RelationshipXref
id: GO:0004331
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref372
type: UnificationXref
id: REACT_148763
db: Reactome
id version: 4
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_148763.4

RelationshipXref23
type: RelationshipXref
id: 4229750
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229750

UnificationXref371
type: UnificationXref
id: 4230251
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230251

UnificationXref378
type: UnificationXref
id: CHEBI:15346
db: ChEBI

UnificationXref377
type: UnificationXref
id: REACT_2705
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2705.2

UnificationXref376
type: UnificationXref
id: 73871
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73871

UnificationXref375
type: UnificationXref
id: CHEBI:15345
db: ChEBI

RelationshipXref29
type: RelationshipXref
id: GO:0004345
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref28
type: RelationshipXref
id: GO:0019388
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref379
type: UnificationXref
id: 29374
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29374

S-Adenosyl-L-methionine [ChEBI:15414]
type: SmallMoleculeReference
name: S-Adenosyl-L-methionine
name: Acylcarnitine
name: S-Adenosylmethionine
xref: UnificationXref697

RelationshipXref25
type: RelationshipXref
id: GO:0006006
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref24
type: RelationshipXref
id: GO:0006094
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref27
type: RelationshipXref
id: 4229756
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229756

RelationshipXref26
type: RelationshipXref
id: GO:0003978
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref386
type: UnificationXref
id: 4230227
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230227

UnificationXref387
type: UnificationXref
id: REACT_97151
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_97151.9

UnificationXref388
type: UnificationXref
id: 4231288
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231288

UnificationXref389
type: UnificationXref
id: REACT_80882
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80882.9

UnificationXref382
type: UnificationXref
id: 73917
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73917

UnificationXref383
type: UnificationXref
id: REACT_3208
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3208.2

UnificationXref384
type: UnificationXref
id: Q7A3F6
db: UniProt

http://identifiers.org/pubmed/1703535
type: PublicationXref
id: 1703535
author: Purdue, PE
author: Danpure, CJ
author: Takada, Y
db: Pubmed
title: Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
source: J Cell Biol 111:2341-51
year: 1990

UnificationXref385
type: UnificationXref
id: 4230225
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230225

UnificationXref380
type: UnificationXref
id: REACT_3654
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3654.2

UnificationXref381
type: UnificationXref
id: CHEBI:15467
db: ChEBI

http://identifiers.org/pubmed/7503232
type: PublicationXref
id: 7503232
author: Ecelbarger, CA
author: Knepper, MA
author: Marples, D
author: Terris, J
author: Nielsen, S
author: Frindt, G
author: Echevarria, M
db: Pubmed
title: Aquaporin-3 water channel localization and regulation in rat kidney
source: Am J Physiol 269:F663-72
year: 1995

http://identifiers.org/pubmed/16319917
type: PublicationXref
id: 16319917
author: Newman, SC
author: Radomski, MW
author: Jurasz, P
author: Lara, N
author: Le Mellédo, JM
author: Baker, G
author: Archer, SL
author: Chrapko, W
db: Pubmed
title: Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients
source: Neuropsychopharmacology 31:1286-93
year: 2006

UnificationXref399
type: UnificationXref
id: REACT_3082
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3082.1

UnificationXref397
type: UnificationXref
id: CHEBI:17877
db: ChEBI

UnificationXref398
type: UnificationXref
id: 31649
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31649

UnificationXref395
type: UnificationXref
id: 188458
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188458

UnificationXref396
type: UnificationXref
id: REACT_18103
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18103.2

UnificationXref393
type: UnificationXref
id: 113596
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113596

UnificationXref394
type: UnificationXref
id: REACT_5229
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5229.1

UnificationXref391
type: UnificationXref
id: REACT_95478
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_95478.9

UnificationXref392
type: UnificationXref
id: CHEBI:16238
db: ChEBI

UnificationXref390
type: UnificationXref
id: 4231289
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231289

http://identifiers.org/pubmed/16788062
type: PublicationXref
id: 16788062
author: Schwer, B
author: Verdin, E
author: Andersen, JS
author: Verdin, RO
author: Bunkenborg, J
db: Pubmed
title: Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
source: Proc Natl Acad Sci U S A 103:10224-9
year: 2006

http://identifiers.org/pubmed/12881475
type: PublicationXref
id: 12881475
author: Koesling, D
author: Friebe, A
db: Pubmed
title: Regulation of nitric oxide-sensitive guanylyl cyclase
source: Circ Res 93:96-105
year: 2003

http://identifiers.org/pubmed/15217342
type: PublicationXref
id: 15217342
author: Sudhof, TC
db: Pubmed
title: The synaptic vesicle cycle
source: Annu Rev Neurosci 27:509-47
year: 2004

Acetic acid,phenyl ester
type: SmallMoleculeReference
name: Phenyl acetate [ChEBI:8082]
name: Acetylphenol
name: Phenyl acetate
xref: UnificationXref2184

http://identifiers.org/pubmed/8340387
type: PublicationXref
id: 8340387
author: Tyrsted, G
author: Munch-Petersen, B
author: Cloos, L
db: Pubmed
title: Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties
source: J Biol Chem 268:15621-15625
year: 1993

Histidine catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction134
pathway component: BiochemicalReaction136
pathway component: BiochemicalReaction135
evidence: Evidence216
xref: RelationshipXref265
xref: UnificationXref1701
xref: UnificationXref1700
pathway order: PathwayStep212
pathway order: PathwayStep211
pathway order: PathwayStep210
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

HGPRT homotetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry115
component stoichiometry: Stoichiometry114
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref1052
cellular location: intracellular
comment: Reactome DB_ID: 4230237

APRT homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry113
component: Adenine phosphoribosyltransferase
xref: UnificationXref1037
cellular location: intracellular
comment: Reactome DB_ID: 4230231

AMPD3 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry112
component: Homologues of AMPD3
xref: UnificationXref1029
cellular location: intracellular
comment: Reactome DB_ID: 4230264

adenylosuccinate synthetase holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry109
component stoichiometry: Stoichiometry110
component: IMP--aspartate ligase 2
component: Mg++
xref: UnificationXref1010
cellular location: intracellular
comment: Reactome DB_ID: 4230373

CAD hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry128
component: Homologues of CAD
xref: UnificationXref1126
cellular location: intracellular
comment: Reactome DB_ID: 4230102

catalase holoenzyme monomer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry124
component stoichiometry: Stoichiometry122
component stoichiometry: Stoichiometry123
component: Note: the coordinates are copied over from Homo sapiens.
component: protoheme
component: NADPH
xref: UnificationXref1107
cellular location: intracellular
comment: Reactome DB_ID: 4230256

CAT tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry125
component: catalase holoenzyme monomer (name copied from entity in Homo sapiens)
xref: UnificationXref1108
cellular location: intracellular
comment: Reactome DB_ID: 4230257

5'-nucleotidase, ecto (CD73) holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry117
component stoichiometry: Stoichiometry116
component: Note: the coordinates are copied over from Homo sapiens.
component: zinc
xref: UnificationXref1087
cellular location: plasma membrane
comment: Reactome DB_ID: 4230273

dITP
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-triphosphate
name: dITP [ChEBI:10499]
name: 2'-Deoxyinosine-5'-triphosphate
xref: UnificationXref1397

2'-Deoxyinosine 5'-phosphate [ChEBI:28806]
type: SmallMoleculeReference
name: 2'-Deoxyinosine 5'-phosphate
name: dIMP
xref: UnificationXref1400

http://identifiers.org/pubmed/22653731
type: PublicationXref
id: 22653731
author: Levin, Aron M
author: Waghray, Deepa
author: Thomas, Christoph
author: Garcia, K Christopher
author: Janda, Claudia Y
db: Pubmed
title: Structural basis of Wnt recognition by Frizzled
source: Science 337:59-64
year: 2012

adenylosuccinate synthetase like 1 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry106
component stoichiometry: Stoichiometry107
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref1007
cellular location: intracellular
comment: Reactome DB_ID: 4230370

adenylosuccinate synthetase holoenzyme dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry111
component: adenylosuccinate synthetase holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref1011
cellular location: intracellular
comment: Reactome DB_ID: 4230374

http://identifiers.org/pubmed/2066663
type: PublicationXref
id: 2066663
author: Ameis, D
author: Sternby, B
author: Schotz, MC
author: Leete, TH
author: Reue, K
author: Ronk, M
author: Borgstrom, B
author: Lee, G
author: Zambaux, J
author: Wong, H
author: Shively, JE
db: Pubmed
title: cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit
source: J Lipid Res 32:267-76
year: 1991

PPAT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry98
component stoichiometry: Stoichiometry97
component stoichiometry: Stoichiometry96
component: sulfur
component: Fe(III)
component: P99164
xref: UnificationXref888
cellular location: intracellular
comment: Reactome DB_ID: 4230198

fumarate hydratase tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry95
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref852
cellular location: intracellular
comment: Reactome DB_ID: 4229962

PAICS octamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry102
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref951
cellular location: intracellular
comment: Reactome DB_ID: 4230181

PPAT tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry100
component: PPAT dimer (name copied from entity in Homo sapiens)
xref: UnificationXref889
cellular location: intracellular
comment: Reactome DB_ID: 4230200

ATIC dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry104
component: P67544
xref: UnificationXref978
cellular location: intracellular
comment: Reactome DB_ID: 4230167

adenylosuccinate lyase tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry103
component: ASASE
xref: UnificationXref970
cellular location: intracellular
comment: Reactome DB_ID: 4230175

ADSS, ADSSL1 dimers
type: Complex
data source: Reactome
member physical entity: adenylosuccinate synthetase holoenzyme dimer (name copied from entity in Homo sapiens)
member physical entity: adenylosuccinate synthetase like 1 holoenzyme dimer (name copied from entity in Homo sapiens)
xref: UnificationXref1012
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230375

IMP (inosine monophosphate) dehydrogenase 1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry105
component: P99106
xref: UnificationXref988
cellular location: intracellular
comment: Reactome DB_ID: 4230160

adenylosuccinate synthetase like 1 holoenzyme dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry108
component: adenylosuccinate synthetase like 1 holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref1008
cellular location: intracellular
comment: Reactome DB_ID: 4230371

Ketone body metabolism
type: Pathway
data source: Reactome
pathway component: REACT 80882.9
evidence: Evidence48
xref: UnificationXref390
xref: UnificationXref391
xref: RelationshipXref54
pathway order: PathwayStep44
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18483217
type: PublicationXref
id: 18483217
author: Betsholtz, C
author: Andrae, J
author: Gallini, R
db: Pubmed
title: Role of platelet-derived growth factors in physiology and medicine
source: Genes Dev 22:1276-312
year: 2008

Ion channel transport
type: Pathway
data source: Reactome
pathway component: REACT 126481.5
pathway component: REACT 162081.2
evidence: Evidence417
xref: RelationshipXref482
xref: UnificationXref2962
xref: UnificationXref2961
pathway order: PathwayStep403
pathway order: PathwayStep407
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/10903473
type: PublicationXref
id: 10903473
author: Sprecher, H
db: Pubmed
title: Metabolism of highly unsaturated n-3 and n-6 fatty acids
source: Biochim Biophys Acta 1486:219-31
year: 2000

alpha-ketoglutarate dehydrogenase E1 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry91
component stoichiometry: Stoichiometry92
component: Thiamin diphosphate
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref839
cellular location: intracellular
comment: Reactome DB_ID: 4229968

alpha-keto acid dehydrogenase E3 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry84
component stoichiometry: Stoichiometry85
component: Flavin adenine dinucleotide
component: Glycine cleavage system L protein
xref: UnificationXref825
cellular location: intracellular
comment: Reactome DB_ID: 4229916

http://identifiers.org/pubmed/11514232
type: PublicationXref
id: 11514232
author: Lombardo, D
db: Pubmed
title: Bile salt-dependent lipase: its pathophysiological implications
source: Biochim Biophys Acta 1533:1-28
year: 2001

alpha-keto acid dehydrogenase E3 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry86
component: alpha-keto acid dehydrogenase E3 holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref826
cellular location: intracellular
comment: Reactome DB_ID: 4229917

alpha-ketoglutarate dehydrogenase complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry90
component stoichiometry: Stoichiometry87
component stoichiometry: Stoichiometry94
component: alpha-ketoglutarate dehydrogenase E1 homodimer (name copied from entity in Homo sapiens)
component: alpha-ketoglutarate dehydrogenase E2 holoenzyme (name copied from entity in Homo sapiens)
component: alpha-keto acid dehydrogenase E3 homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref841
cellular location: intracellular
comment: Reactome DB_ID: 4229975

NNT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry83
component: Homologues of NNT
xref: UnificationXref814
cellular location: intracellular
comment: Reactome DB_ID: 4230973

Citrate Synthase Holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry82
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref798
cellular location: intracellular
comment: Reactome DB_ID: 4229956

lactate dehydrogenase B4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry81
component: Homologues of LDHB
xref: UnificationXref784
cellular location: intracellular
comment: Reactome DB_ID: 4229830

lactate dehydrogenase AB3 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry80
component stoichiometry: Stoichiometry79
component: Homologues of LDHB
component: Homologues of LDHA
xref: UnificationXref783
cellular location: intracellular
comment: Reactome DB_ID: 4229829

lactate dehydrogenase A4 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry78
component: Homologues of LDHA
xref: UnificationXref782
cellular location: intracellular
comment: Reactome DB_ID: 4229828

http://identifiers.org/pubmed/18802471
type: PublicationXref
id: 18802471
author: Jefferies, WA
author: Seipp, RP
author: Basha, G
author: Omilusik, KD
author: Lizée, G
author: Reinicke, AT
db: Pubmed
title: MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells
source: PLoS One 3:e3247
year: 2008

alpha-ketoglutarate dehydrogenase E1 homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry93
component: alpha-ketoglutarate dehydrogenase E1 holoenzyme (name copied from entity in Homo sapiens)
xref: UnificationXref840
cellular location: intracellular
comment: Reactome DB_ID: 4229969

alpha-ketoglutarate dehydrogenase E2 holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry88
component stoichiometry: Stoichiometry89
component: Note: the coordinates are copied over from Homo sapiens.
component: Lipoamide
xref: UnificationXref833
cellular location: intracellular
comment: Reactome DB_ID: 4229974

http://identifiers.org/pubmed/15952902
type: PublicationXref
id: 15952902
author: Kaufman, RJ
author: Schröder, M
db: Pubmed
title: The mammalian unfolded protein response
source: Annu Rev Biochem 74:739-89
year: 2005

palmitoylated, myristoylated eNOS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry66
component stoichiometry: Stoichiometry62
component stoichiometry: Stoichiometry63
component stoichiometry: Stoichiometry64
component stoichiometry: Stoichiometry65
component: Note: the coordinates are copied over from Homo sapiens.
component: Flavin adenine dinucleotide
component: heme (ferrous)
component: Riboflavin-5-phosphate
component: Zn(II)
xref: UnificationXref741
cellular location: plasma membrane
comment: Reactome DB_ID: 4230608

PDSS1:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry59
component stoichiometry: Stoichiometry58
component: Q7A5J3
component: magnesium
xref: UnificationXref690
cellular location: intracellular
comment: Reactome DB_ID: 4231202

DHFR dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry73
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref757
cellular location: intracellular
comment: Reactome DB_ID: 4231125

myristoylated eNOS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry68
component stoichiometry: Stoichiometry70
component stoichiometry: Stoichiometry69
component stoichiometry: Stoichiometry72
component stoichiometry: Stoichiometry67
component stoichiometry: Stoichiometry71
component: Note: the coordinates are copied over from Homo sapiens.
component: Flavin adenine dinucleotide
component: heme (ferrous)
component: 5,6,7,8-Tetrahydrobiopterin
component: Riboflavin-5-phosphate
component: Zn(II)
xref: UnificationXref747
cellular location: intracellular
comment: Reactome DB_ID: 4230603

http://identifiers.org/pubmed/11573934
type: PublicationXref
id: 11573934
author: Suda, T
author: Hatakeyama, S
author: Ohshiro, K
author: Tani, T
author: Kamiie, JI
author: Yoshida, Y
author: Yamamoto, T
author: Hatakeyama, K
author: Nihei, K
author: Yaoita, E
author: Koyama, Y
db: Pubmed
title: Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum
source: Biochem Biophys Res Commun 287:814-9
year: 2001

GPX1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry50
component: Homologues of L-selenocysteine residue-GPX1
xref: UnificationXref607
cellular location: intracellular
comment: Reactome DB_ID: 4230044

PDSS1/2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry57
component stoichiometry: Stoichiometry60
component: PDSS1:Mg2+ (name copied from entity in Homo sapiens)
component: Q7A5J3
xref: UnificationXref691
cellular location: intracellular
comment: Reactome DB_ID: 4231204

GPX2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry52
component: Homologues of GPX2
xref: UnificationXref625
cellular location: intracellular
comment: Reactome DB_ID: 4231175

http://identifiers.org/pubmed/15607730
type: PublicationXref
id: 15607730
author: Kunzelmann, K
author: Markovich, D
author: Regeer, RR
author: Dawson, PA
db: Pubmed
title: Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)
source: Biochem Biophys Res Commun 326:729-34
year: 2005

lactate dehydrogenase A2B2 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry75
component stoichiometry: Stoichiometry74
component: Homologues of LDHB
component: Homologues of LDHA
xref: UnificationXref780
cellular location: intracellular
comment: Reactome DB_ID: 4229826

lactate dehydrogenase complex
type: Complex
data source: Reactome
member physical entity: lactate dehydrogenase A4 complex (name copied from entity in Homo sapiens)
member physical entity: lactate dehydrogenase A2B2 complex (name copied from entity in Homo sapiens)
member physical entity: lactate dehydrogenase AB3 complex (name copied from entity in Homo sapiens)
member physical entity: lactate dehydrogenase A3B complex (name copied from entity in Homo sapiens)
member physical entity: lactate dehydrogenase B4 complex (name copied from entity in Homo sapiens)
xref: UnificationXref785
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4229831

lactate dehydrogenase A3B complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry77
component stoichiometry: Stoichiometry76
component: Homologues of LDHB
component: Homologues of LDHA
xref: UnificationXref781
cellular location: intracellular
comment: Reactome DB_ID: 4229827

UniProt:P66767
type: ProteinReference
xref: UnificationXref1928
organism: BioSource1

dCDP
type: SmallMoleculeReference
name: dCDP [ChEBI:28846]
name: 2'-Deoxycytidine diphosphate
name: 2'-Deoxycytidine 5'-diphosphate
xref: UnificationXref1309

Sulfur amino acid metabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction162
pathway component: REACT 126330.5
pathway component: BiochemicalReaction161
evidence: Evidence258
xref: UnificationXref1970
xref: RelationshipXref325
xref: UnificationXref1969
pathway order: PathwayStep250
pathway order: PathwayStep251
pathway order: PathwayStep254
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/17157489
type: PublicationXref
id: 17157489
author: Monu, N
author: Trombetta, ES
db: Pubmed
title: Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules
source: Curr Opin Immunol 19:66-72
year: 2007

5'-Phosphoribosyl-5-aminoimidazole [ChEBI:28843]
type: SmallMoleculeReference
name: 5'-Phosphoribosyl-5-aminoimidazole
name: Aminoimidazole ribotide
name: 1-(5'-Phosphoribosyl)-5-aminoimidazole
name: 1-(5-Phospho-D-ribosyl)-5-aminoimidazole
name: AIR
xref: UnificationXref941

UniProt:P67047
type: ProteinReference
xref: UnificationXref1189
organism: BioSource1

http://identifiers.org/pubmed/8567683
type: PublicationXref
id: 8567683
author: Beardsley, GP
author: Moroson, BA
author: Rayl, EA
db: Pubmed
title: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
source: J Biol Chem 271:2225-2233
year: 1996

dUDP [ChEBI:28850]
type: SmallMoleculeReference
name: 2'-Deoxyuridine 5'-diphosphate
name: dUDP
xref: UnificationXref1315

http://identifiers.org/pubmed/15703994
type: PublicationXref
id: 15703994
author: Wray, S
author: Marples, D
author: Mobasheri, A
db: Pubmed
title: Distribution of AQP2 and AQP3 water channels in human tissue microarrays
source: J Mol Histol 36:1-14
year: 2005

2xMOCS2-CO-S(1-):2xMOCS2B (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry172
component stoichiometry: Stoichiometry171
component: Protein118
component: Protein117
xref: UnificationXref1577
cellular location: intracellular
comment: Reactome DB_ID: 4231062

2xMOCS2A:2xMOCS2B (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry173
component stoichiometry: Stoichiometry174
component: Protein118
component: Protein119
xref: UnificationXref1579
cellular location: intracellular
comment: Reactome DB_ID: 4231063

2xMTHFD1 (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry167
component: Protein114
xref: UnificationXref1534
cellular location: intracellular
comment: Reactome DB_ID: 4230588

holo-MOCS1 (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry170
component stoichiometry: Stoichiometry169
component stoichiometry: Stoichiometry168
component: Protein115
component: Protein116
component: SmallMolecule310
xref: UnificationXref1570
cellular location: intracellular
comment: Reactome DB_ID: 4231053

4x(Btn-PC:Mn2+) (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry152
component stoichiometry: Stoichiometry153
component: Protein110
component: Mn(III)
xref: UnificationXref1474
cellular location: intracellular
comment: Reactome DB_ID: 4231250

2xNAPRT1 (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry154
component: Protein111
xref: UnificationXref1487
cellular location: intracellular
comment: Reactome DB_ID: 4230540

4x(Btn-PC:Mn2+) (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry151
component stoichiometry: Stoichiometry150
component: Protein110
component: Mn(III)
xref: UnificationXref1473
cellular location: intracellular
comment: Reactome DB_ID: 4231244

3xPPCDC:3xFMN (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry147
component stoichiometry: Stoichiometry146
component: Protein108
component: Riboflavin-5-phosphate
xref: UnificationXref1447
cellular location: intracellular
comment: Reactome DB_ID: 4230529

ITPA dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry143
component: Protein103
xref: UnificationXref1393
cellular location: intracellular
comment: Reactome DB_ID: 4231214

NME4 hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry142
component: Protein102
xref: UnificationXref1381
cellular location: intracellular
comment: Reactome DB_ID: 4230989

http://identifiers.org/pubmed/10727395
type: PublicationXref
id: 10727395
author: Thöny, B
author: Blau, N
author: Auerbach, G
db: Pubmed
title: Tetrahydrobiopterin biosynthesis, regeneration and functions
source: Biochem J 347:1-16
year: 2000

http://identifiers.org/pubmed/18762715
type: PublicationXref
id: 18762715
author: Ohta, KY
author: Yuasa, H
author: Inoue, K
author: Ishii, M
author: Katano, T
author: Watanabe, J
author: Ohgusu, Y
author: Urano, K
db: Pubmed
title: Functional characterization of human aquaporin 9 as a facilitative glycerol carrier
source: Drug Metab Pharmacokinet 23:279-84
year: 2008

http://identifiers.org/pubmed/12495737
type: PublicationXref
id: 12495737
author: Elliott, T
author: Antoniou, AN
author: Powis, SJ
db: Pubmed
title: Assembly and export of MHC class I peptide ligands
source: Curr Opin Immunol 15:75-81
year: 2003

TK1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry138
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1243
cellular location: intracellular
comment: Reactome DB_ID: 4230143

CDA tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry139
component stoichiometry: Stoichiometry140
component: Note: the coordinates are copied over from Homo sapiens.
component: Zn(II)
xref: UnificationXref1255
cellular location: intracellular
comment: Reactome DB_ID: 4230137

nucleoside diphosphate kinase 1A:5B heterohexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry141
component: Protein101
xref: UnificationXref1339
cellular location: intracellular
comment: Reactome DB_ID: 4230984

TS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry133
component stoichiometry: Stoichiometry134
component: Note: the coordinates are copied over from Homo sapiens.
component: Mg++
xref: UnificationXref1191
cellular location: intracellular
comment: Reactome DB_ID: 4230131

TYMP dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry135
component: Thymidine phosphorylase precursor
xref: UnificationXref1217
cellular location: intracellular
comment: Reactome DB_ID: 4230390

UniProt:P67062
type: ProteinReference
xref: UnificationXref708
organism: BioSource1

UCK1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry136
component: UCK 1
xref: UnificationXref1235
cellular location: intracellular
comment: Reactome DB_ID: 4230125

UCK2 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry137
component: Uridine monophosphokinase 2
xref: UnificationXref1239
cellular location: intracellular
comment: Reactome DB_ID: 4230304

dihydroorotate dehydrogenase holoenzyme (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry129
component stoichiometry: Stoichiometry130
component: Dihydroorotate oxidase
component: flavin mononucleotide
xref: UnificationXref1153
cellular location: intracellular
comment: Reactome DB_ID: 4230096

DCTD hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry132
component: Q7A5B8
xref: UnificationXref1180
cellular location: intracellular
comment: Reactome DB_ID: 4230119

UMPS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry131
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref1161
cellular location: intracellular
comment: Reactome DB_ID: 4230088

mitochondrial inner membrane
type: CellularLocationVocabulary
xref: UnificationXref1139

deoxycytidine 5'-triphosphate
type: SmallMoleculeReference
name: dCTP [ChEBI:16311]
name: dCTP
name: Deoxycytidine triphosphate
name: 2'-Deoxycytidine 5'-triphosphate
xref: UnificationXref1326

2'-Deoxyguanosine 5'-diphosphate
type: SmallMoleculeReference
name: dGDP [ChEBI:28862]
name: dGDP
xref: UnificationXref1289

Taurocholate [ChEBI:9408]
type: SmallMoleculeReference
name: Cholyltaurine
name: Taurocholic acid
name: Taurocholate
xref: UnificationXref324

UniProt:P67015
type: ProteinReference
xref: UnificationXref2359
organism: BioSource1

UnificationXref10
type: UnificationXref
id: REACT_2991
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2991.3

UnificationXref11
type: UnificationXref
id: CHEBI:18009
db: ChEBI

UnificationXref12
type: UnificationXref
id: 29366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366

UnificationXref13
type: UnificationXref
id: REACT_4609
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4609.3

UnificationXref14
type: UnificationXref
id: CHEBI:16349
db: ChEBI

UnificationXref15
type: UnificationXref
id: 29968
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29968

UnificationXref16
type: UnificationXref
id: REACT_3861
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3861.3

UnificationXref17
type: UnificationXref
id: CHEBI:16480
db: ChEBI

UnificationXref18
type: UnificationXref
id: 202124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=202124

UnificationXref19
type: UnificationXref
id: REACT_13183
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13183.2

http://identifiers.org/pubmed/1772073
type: PublicationXref
id: 1772073
author: Peters, JC
db: Pubmed
title: Tryptophan nutrition and metabolism: an overview
source: Adv Exp Med Biol 294:345-58
year: 1991

Metabolism of proteins
type: Pathway
data source: Reactome
pathway component: Unfolded Protein Response
pathway component: Post-translational protein modification
evidence: Evidence430
xref: RelationshipXref498
xref: UnificationXref3004
xref: UnificationXref3005
pathway order: PathwayStep415
pathway order: PathwayStep419
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref23
type: UnificationXref
id: 4230610
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230610

UnificationXref24
type: UnificationXref
id: 4230779
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230779

http://identifiers.org/pubmed/17125408
type: PublicationXref
id: 17125408
author: Baltes, E
author: Strolin Benedetti, M
author: Whomsley, R
db: Pubmed
title: Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics
source: Expert Opin Drug Metab Toxicol 2:895-921
year: 2006

UnificationXref21
type: UnificationXref
id: P0A093
db: UniProt

UnificationXref22
type: UnificationXref
id: 4230778
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230778

UnificationXref20
type: UnificationXref
id: GO:0005622
db: GENE ONTOLOGY

UnificationXref29
type: UnificationXref
id: ECO:0000203
db: EVIDENCE CODE

http://identifiers.org/pubmed/3090932
type: PublicationXref
id: 3090932
author: Griffith, OW
db: Pubmed
title: Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues
source: Annu Rev Biochem 55:855-878
year: 1986

UnificationXref27
type: UnificationXref
id: 4230782
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230782

UnificationXref28
type: UnificationXref
id: REACT_153224
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153224.3

UnificationXref25
type: UnificationXref
id: 4230780
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230780

UnificationXref26
type: UnificationXref
id: MI:0355
db: MI

http://identifiers.org/pubmed/807573
type: PublicationXref
id: 807573
author: Beutler, E
author: Srivastava, S K
author: Awasthi, Y C
db: Pubmed
title: Purification and properties of human erythrocyte glutathione peroxidase
source: J. Biol. Chem. 250:5144-9
year: 1975

UnificationXref32
type: UnificationXref
id: 4231368
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231368

UnificationXref33
type: UnificationXref
id: REACT_159506
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159506.3

UnificationXref34
type: UnificationXref
id: 4231369
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231369

UnificationXref35
type: UnificationXref
id: REACT_159261
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159261.3

UnificationXref30
type: UnificationXref
id: 4231367
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231367

UnificationXref31
type: UnificationXref
id: REACT_153086
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153086.3

mitochondrial intermembrane space
type: CellularLocationVocabulary
xref: UnificationXref2020

http://identifiers.org/pubmed/10794676
type: PublicationXref
id: 10794676
author: Ganapathy, V
author: Prasad, PD
author: Kekuda, R
author: Wang, H
author: Devoe, LD
author: Leibach, FH
author: Yang-Feng, TL
author: Fei, YJ
db: Pubmed
title: Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter
source: Am J Physiol Cell Physiol 278:C1019-30
year: 2000

UnificationXref36
type: UnificationXref
id: MI:0359
db: MI

UnificationXref37
type: UnificationXref
id: Q7A559
db: UniProt

mitochondrial matrix
type: CellularLocationVocabulary
xref: UnificationXref171

UnificationXref38
type: UnificationXref
id: 4230026
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230026

UnificationXref39
type: UnificationXref
id: 4230416
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230416

2-Amino-5-ureidovaleric acid
type: SmallMoleculeReference
name: L-Citrulline [ChEBI:16349]
name: L-Citrulline
xref: UnificationXref14

Amino Acid conjugation
type: Pathway
data source: Reactome
pathway component: REACT 94419.9
evidence: Evidence291
xref: UnificationXref2207
xref: RelationshipXref347
xref: UnificationXref2206
pathway order: PathwayStep286
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/7913309
type: PublicationXref
id: 7913309
author: Rokosz, LL
author: Cueto, MA
author: Butkiewicz, EA
author: Hermes, JD
author: Boulton, DA
author: Sanyal, G
author: Lachance, PA
db: Pubmed
title: Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes
source: Arch Biochem Biophys 312:1-13
year: 1994

Cholate
type: SmallMoleculeReference
name: Cholic acid
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
name: ChEBI:16359 Cholate
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid
xref: UnificationXref318

http://identifiers.org/pubmed/19244215
type: PublicationXref
id: 19244215
author: Buczynski, MW
author: Dumlao, DS
author: Dennis, EA
db: Pubmed
title: Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
source: J Lipid Res 50:1015-38
year: 2009

http://identifiers.org/pubmed/16116111
type: PublicationXref
id: 16116111
author: Palos, TP
author: Wan, J
author: Jen, JC
author: Howard, BD
author: Baloh, RW
db: Pubmed
title: Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures
source: Neurology 65:529-34
year: 2005

adenosine
type: SmallMoleculeReference
name: adenosine [ChEBI:16335]
xref: UnificationXref1067

D-Xylulose 5-phosphate
type: SmallMoleculeReference
name: D-Xylulose 5-phosphate [ChEBI:16332]
xref: UnificationXref262

http://identifiers.org/pubmed/11698644
type: PublicationXref
id: 11698644
author: Kabashima, T
author: Uyeda, K
author: Kawaguchi, T
author: Takenoshita, M
db: Pubmed
title: Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
source: Proc Natl Acad Sci U S A 98:13710-5
year: 2001

http://identifiers.org/pubmed/18494801
type: PublicationXref
id: 18494801
author: Hildebrandt, TM
author: Grieshaber, MK
db: Pubmed
title: Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria
source: FEBS J 275:3352-61
year: 2008

UnificationXref83
type: UnificationXref
id: P99165
db: UniProt

UnificationXref84
type: UnificationXref
id: 4229774
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229774

UnificationXref85
type: UnificationXref
id: 4229775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229775

UnificationXref86
type: UnificationXref
id: 4229776
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229776

UnificationXref87
type: UnificationXref
id: 4229777
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229777

http://identifiers.org/pubmed/8379904
type: PublicationXref
id: 8379904
author: Gerich, JE
db: Pubmed
title: Control of glycaemia
source: Baillieres Clin Endocrinol Metab 7:551-86
year: 1993

UnificationXref88
type: UnificationXref
id: 4229778
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229778

UnificationXref89
type: UnificationXref
id: 4229779
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229779

UnificationXref537
type: UnificationXref
id: REACT_124098
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124098.1

UnificationXref538
type: UnificationXref
id: CHEBI:65132
db: ChEBI

UnificationXref539
type: UnificationXref
id: 2066765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066765

UnificationXref533
type: UnificationXref
id: 4231359
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231359

UnificationXref534
type: UnificationXref
id: REACT_134420
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_134420.5

UnificationXref535
type: UnificationXref
id: CHEBI:65131
db: ChEBI

UnificationXref536
type: UnificationXref
id: 2066762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2066762

UnificationXref530
type: UnificationXref
id: REACT_126082
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_126082.5

RelationshipXref333
type: RelationshipXref
id: GO:0004729
db: GENE ONTOLOGY
relationship type: MI:0355

Na+
type: SmallMoleculeReference
name: Sodium
name: Sodium [ChEBI:29101]
xref: UnificationXref1414

RelationshipXref332
type: RelationshipXref
id: 4230469
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230469

UnificationXref532
type: UnificationXref
id: REACT_137619
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_137619.5

RelationshipXref335
type: RelationshipXref
id: GO:0004325
db: GENE ONTOLOGY
relationship type: MI:0355

K+
type: SmallMoleculeReference
name: potassium(1+)
name: Potassium
name: potassium(1+) [ChEBI:29103]
xref: UnificationXref148

UnificationXref531
type: UnificationXref
id: 4231358
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231358

RelationshipXref334
type: RelationshipXref
id: 4230463
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230463

CoQ
type: SmallMoleculeReference
name: Coenzyme Q
name: Q
name: Ubiquinone
name: Ubiquinone [ChEBI:16389]
xref: UnificationXref1140

Zinc [ChEBI:29105]
type: SmallMoleculeReference
name: Zinc
name: Zn2+
name: Zn(II)
xref: UnificationXref729

RelationshipXref331
type: RelationshipXref
id: GO:0004853
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref330
type: RelationshipXref
id: 4230457
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230457

UnificationXref91
type: UnificationXref
id: 4229781
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229781

RelationshipXref337
type: RelationshipXref
id: GO:0008495
db: GENE ONTOLOGY
relationship type: MI:0355

Iodide [ChEBI:5946]
type: SmallMoleculeReference
name: Iodide
name: I-
xref: UnificationXref1888

UnificationXref90
type: UnificationXref
id: 4229780
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229780

RelationshipXref336
type: RelationshipXref
id: 4230482
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230482

UnificationXref93
type: UnificationXref
id: REACT_32340
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32340.10

RelationshipXref339
type: RelationshipXref
id: GO:0006783
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref92
type: UnificationXref
id: 4229783
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229783

RelationshipXref338
type: RelationshipXref
id: 4231248
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231248

UnificationXref96
type: UnificationXref
id: 76577
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76577

UnificationXref97
type: UnificationXref
id: REACT_2677
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2677.2

UnificationXref94
type: UnificationXref
id: 4229784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229784

UnificationXref95
type: UnificationXref
id: CHEBI:16027
db: ChEBI

UnificationXref98
type: UnificationXref
id: 4229786
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229786

UnificationXref99
type: UnificationXref
id: 4229785
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229785

UnificationXref528
type: UnificationXref
id: REACT_145347
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_145347.5

UnificationXref529
type: UnificationXref
id: 4231357
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231357

UnificationXref526
type: UnificationXref
id: 4231118
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231118

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
type: Pathway
data source: Reactome
pathway component: alpha-linolenic acid (ALA) metabolism
evidence: Evidence73
xref: UnificationXref546
xref: UnificationXref545
xref: RelationshipXref84
pathway order: PathwayStep69
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11001804
type: PublicationXref
id: 11001804
author: Lucock, M
db: Pubmed
title: Folic acid: nutritional biochemistry, molecular biology, and role in disease processes
source: Mol Genet Metab 71:121-38
year: 2000

UnificationXref527
type: UnificationXref
id: 4231120
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231120

UnificationXref524
type: UnificationXref
id: 4231116
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231116

UnificationXref525
type: UnificationXref
id: 4231117
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231117

UnificationXref522
type: UnificationXref
id: 4231114
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231114

UnificationXref523
type: UnificationXref
id: 4231115
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231115

UnificationXref521
type: UnificationXref
id: REACT_122526
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_122526.1

RelationshipXref324
type: RelationshipXref
id: GO:0000098
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref520
type: UnificationXref
id: 1524060
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524060

RelationshipXref323
type: RelationshipXref
id: GO:0070221
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref322
type: RelationshipXref
id: 4231143
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231143

RelationshipXref321
type: RelationshipXref
id: GO:0070224
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref320
type: RelationshipXref
id: 4231137
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231137

RelationshipXref329
type: RelationshipXref
id: GO:0004418
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref328
type: RelationshipXref
id: 4230475
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230475

N-hydroxy-4-aminobiphenyl O-acetylated conjugate
type: SmallMoleculeReference
name: N-hydroxy-4-aminobiphenyl O-acetylated conjugate [ChEBI:16395]
xref: UnificationXref2132

RelationshipXref327
type: RelationshipXref
id: GO:0004655
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref326
type: RelationshipXref
id: GO:0034641
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref325
type: RelationshipXref
id: GO:0000096
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref519
type: UnificationXref
id: CHEBI:16436
db: ChEBI

Pyrimidine salvage reactions
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction94
pathway component: BiochemicalReaction95
pathway component: BiochemicalReaction93
pathway component: BiochemicalReaction92
pathway component: BiochemicalReaction96
evidence: Evidence159
xref: RelationshipXref196
xref: UnificationXref1258
xref: UnificationXref1259
pathway order: PathwayStep153
pathway order: PathwayStep154
pathway order: PathwayStep151
pathway order: PathwayStep155
pathway order: PathwayStep152
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref511
type: UnificationXref
id: 4230663
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230663

UnificationXref512
type: UnificationXref
id: 4230664
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230664

UnificationXref513
type: UnificationXref
id: 4230665
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230665

UnificationXref514
type: UnificationXref
id: 4230667
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230667

UnificationXref515
type: UnificationXref
id: REACT_157695
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157695.3

UnificationXref516
type: UnificationXref
id: CHEBI:36700
db: ChEBI

UnificationXref517
type: UnificationXref
id: 1524071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524071

RelationshipXref360
type: RelationshipXref
id: GO:0019201
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref518
type: UnificationXref
id: REACT_123890
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_123890.1

RelationshipXref351
type: RelationshipXref
id: GO:0052695
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref350
type: RelationshipXref
id: GO:0006065
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref353
type: RelationshipXref
id: 4230439
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230439

RelationshipXref352
type: RelationshipXref
id: GO:0004060
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref355
type: RelationshipXref
id: GO:0016405
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref354
type: RelationshipXref
id: GO:0032259
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref357
type: RelationshipXref
id: 4230410
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230410

UnificationXref510
type: UnificationXref
id: 4230662
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230662

RelationshipXref356
type: RelationshipXref
id: 4230408
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230408

RelationshipXref359
type: RelationshipXref
id: 4231189
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231189

RelationshipXref358
type: RelationshipXref
id: GO:0004022
db: GENE ONTOLOGY
relationship type: MI:0355

http://identifiers.org/pubmed/11698620
type: PublicationXref
id: 11698620
author: Rosenmund, C
author: Takamori, S
author: Rhee, JS
author: Jahn, R
db: Pubmed
title: Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)
source: J Neurosci 21:RC182
year: 2001

UnificationXref508
type: UnificationXref
id: REACT_116629
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_116629.1

UnificationXref509
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

UnificationXref502
type: UnificationXref
id: REACT_15186
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15186.3

UnificationXref503
type: UnificationXref
id: CHEBI:15354
db: ChEBI

UnificationXref500
type: UnificationXref
id: CHEBI:15355
db: ChEBI

UnificationXref501
type: UnificationXref
id: 372533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=372533

UnificationXref506
type: UnificationXref
id: CHEBI:30089
db: ChEBI

UnificationXref507
type: UnificationXref
id: 1524044
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1524044

UnificationXref504
type: UnificationXref
id: 264638
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=264638

UnificationXref505
type: UnificationXref
id: REACT_15210
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15210.2

RelationshipXref342
type: RelationshipXref
id: 4230058
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230058

http://identifiers.org/pubmed/15806399
type: PublicationXref
id: 15806399
author: Moriyama, A
author: Kawai, Y
author: Suchi, M
author: Asai, K
author: Coleman-Campbell, CM
author: Morishita, H
author: Sumi, S
db: Pubmed
title: Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene
source: Hum Genet 116:340-6
year: 2005

RelationshipXref341
type: RelationshipXref
id: GO:0004024
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref340
type: RelationshipXref
id: GO:0006778
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref346
type: RelationshipXref
id: GO:0006069
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref345
type: RelationshipXref
id: 4230063
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230063

RelationshipXref344
type: RelationshipXref
id: 4230962
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230962

RelationshipXref343
type: RelationshipXref
id: GO:0003987
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref349
type: RelationshipXref
id: 4230428
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230428

RelationshipXref348
type: RelationshipXref
id: GO:0003979
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref347
type: RelationshipXref
id: GO:0006805
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref380
type: RelationshipXref
id: GO:0042136
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence111
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/15946682
xref: http://identifiers.org/pubmed/11752427
xref: http://identifiers.org/pubmed/9727038
comment: The mitochondrial alpha-ketoglutarate dehydrogenase complex catalyzes the reaction of alpha-ketoglutarate, CoASH, and NAD+ to form succinyl-CoA, CO2, and NADH. The enzyme complex contains multiple copies of three different proteins, E1 (OGDH), E2 (DLST), and E3 (DLD), each with distinct catalytic activities (Reed and Hackert 1990; Zhou et al 2001). The reaction starts with the oxidative decarboxylation of alpha ketoglutarate catalyzed by E1alpha and beta (alpha ketoglutarate dehydrogenase). Lipoamide cofactor associated with E1 is reduced at the same time. Next, the succinyl group derived from alpha ketoglutarate is transferred to coenzyme A in two steps catalyzed E2 (dihydrolipolyl transacetylase). Finally, the oxidized form of lipoamide is regenerated and electrons are transferred to NAD+ in two steps catalyzed by E3 (dihydrolipoyl dehydrogenase). The biochemical details of this reaction have been worked out with alpha ketoglutarate dehydrogenase complex and subunits purified from bovine tissue (McCartney et al. 1998). While all of the human proteins are known as predicted protein products of cloned genes, direct experimental evidence for their functions is available only for E3 (DLD) (Brautigam et al. 2005).

UnificationXref48
type: UnificationXref
id: 30537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30537

Evidence110
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10673423
xref: http://identifiers.org/pubmed/2005110
comment: NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).

UnificationXref47
type: UnificationXref
id: CHEBI:17665
db: ChEBI

RelationshipXref382
type: RelationshipXref
id: GO:0001504
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref381
type: RelationshipXref
id: 4230636
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230636

UnificationXref49
type: UnificationXref
id: REACT_3817
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3817.2

UnificationXref578
type: UnificationXref
id: REACT_155948
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_155948.3

UnificationXref577
type: UnificationXref
id: 4231432
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231432

endoplasmic reticulum membrane
type: CellularLocationVocabulary
xref: UnificationXref661

Gluconeogenesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction12
pathway component: BiochemicalReaction11
pathway component: BiochemicalReaction10
pathway component: Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
pathway component: BiochemicalReaction14
pathway component: BiochemicalReaction13
evidence: Evidence24
xref: RelationshipXref24
xref: UnificationXref216
xref: UnificationXref217
pathway order: PathwayStep16
pathway order: PathwayStep17
pathway order: PathwayStep20
pathway order: PathwayStep19
pathway order: PathwayStep18
pathway order: PathwayStep15
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

endoplasmic reticulum lumen
type: CellularLocationVocabulary
xref: UnificationXref2933

UnificationXref579
type: UnificationXref
id: CHEBI:15647
db: ChEBI

UnificationXref40
type: UnificationXref
id: REACT_152941
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152941.3

UnificationXref42
type: UnificationXref
id: REACT_153938
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153938.3

UnificationXref41
type: UnificationXref
id: 4231348
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231348

UnificationXref44
type: UnificationXref
id: REACT_153422
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_153422.3

UnificationXref43
type: UnificationXref
id: 4231349
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231349

UnificationXref46
type: UnificationXref
id: REACT_158877
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158877.3

UnificationXref45
type: UnificationXref
id: 4231350
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231350

Evidence109
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/9792662
xref: http://identifiers.org/pubmed/9809442
comment: Mitochondrial citrate synthase dimer catalyzes the irreversible reaction of acetyl-CoA, water, and oxaloacetate to form citrate and coenzyme A. This reaction is the entry point of two-carbon units into the citric acid cycle. The reaction is subject to allosteric regulation. The gene encoding the human enzyme has been cloned (Goldenthal et al. 1998), but the enzyme has not been characterized in detail - its properties are inferred from those of the well-studied homologous pig enzyme (e.g., Morgunov and Srere 1998).

RelationshipXref376
type: RelationshipXref
id: GO:0014047
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence107
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11276087
xref: http://identifiers.org/pubmed/11377399
xref: http://identifiers.org/pubmed/3435492
comment: Cytosolic lactate dehydrogenase catalyzes the freely reversible reaction of lactate and NAD+ to form pyruvate and NADH + H+. In liver parenchymal cells, this reaction allows lactate from red blood cells and exercising muscle to be converted to pyruvate which in turn is typically used for gluconeogenesis which also consumes the NADH from the reaction. Lactate dehydrogenase is active as a tetramer. Two isoforms of lactate dehydrogenase, A and B, are widely expressed in human tissues, and all five tetramers - A4, A3B, A2B2, AB3, and B4 - are found. A third isoform, C, and its tetramer, C4, are found in testis.

UnificationXref573
type: UnificationXref
id: Q7A492
db: UniProt

ethenoadenine
type: SmallMoleculeReference
name: 1H-imidazo[2,1-i]purine
name: ChEBI:29146 1H-imidazo[2,1-i]purine
xref: UnificationXref3082

RelationshipXref377
type: RelationshipXref
id: GO:0015220
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence108
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/2188967
xref: http://identifiers.org/pubmed/7273846
comment: Pyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanine. It can be converted by the pyruvate dehydrogenase complex to acetyl CoA (Reed and Hackert 1990) which can enter the TCA cycle or serve as the starting point for the syntheses of long chain fatty acids, steroids, and ketone bodies depending on the tissue and metabolic state in which it is formed. It also plays a central role in balancing the energy needs of various tissues in the body. Under conditions in which oxygen supply is limiting, e.g., in exercising muscle, or in the absence of mitochondria, e.g., in red blood cells, re-oxidation of NADH produced by glycolysis cannot be coupled to generation of ATP. Instead, re-oxidation is coupled to the reduction of pyruvate to lactate. This lactate is released into the blood, and is taken up primarily by the liver, where it is oxidized to pyruvate and can be used for gluconeogenesis (Cori 1981).

UnificationXref574
type: UnificationXref
id: 4231162
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231162

RelationshipXref378
type: RelationshipXref
id: 4230641
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230641

Evidence105
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/17237348
comment: Nitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blood vessels and muscle relaxation. NO is a highly active molecule that diffuses across cell membranes and cannot be stored inside the producing cell. Its signaling capacity must be controlled at the levels of biosynthesis and local availability. Indeed, NO production by NO synthases is under complex and tight control, being regulated at transcriptional and translational levels, through co- and posttranslational modifications, and by subcellular localization. NO is synthesized from L-arginine by a family of nitric oxide synthases (NOS). Three NOS isoforms have been characterized: neuronal NOS (nNOS, NOS1) primarily found in neuronal tissue and skeletal muscle; inducible NOS (iNOS, NOS2) originally isolated from macrophages and later discovered in many other cells types; and endothelial NOS (eNOS, NOS3) present in vascular endothelial cells, cardiac myocytes, and in blood platelets. The enzymatic activity of all three isoforms is dependent on calmodulin, which binds to nNOS and eNOS at elevated intracellular calcium levels, while it is tightly associated with iNOS even at basal calcium levels. As a result, the enzymatic activity of nNOS and eNOS is modulated by changes in intracellular calcium levels, leading to transient NO production, while iNOS continuously releases NO independent of fluctuations in intracellular calcium levels and is mainly regulated at the gene expression level (Pacher et al. 2007). The NOS enzymes share a common basic structural organization and requirement for substrate cofactors for enzymatic activity. A central calmodulin-binding motif separates an oxygenase (NH2-terminal) domain from a reductase (COOH-terminal) domain. Binding sites for cofactors NADPH, FAD, and FMN are located within the reductase domain, while binding sites for tetrahydrobiopter…

UnificationXref575
type: UnificationXref
id: 4231171
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231171

RelationshipXref379
type: RelationshipXref
id: GO:0007269
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence106
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/11276087
xref: http://identifiers.org/pubmed/11377399
xref: http://identifiers.org/pubmed/3435492
comment: Cytosolic lactate dehydrogenase catalyzes the reversible reaction of pyruvate and NADH + H+ to form lactate and NAD+. In the body under anaerobic conditions such as are found in red blood cells or rapidly exercising skeletal muscle, this reaction regenerates NAD+, allowing the continuation of glycolysis. Lactate dehydrogenase is active as a tetramer. Two isoforms of lactate dehydrogenase, A and B, are widely expressed in human tissues, and all five tetramers - A4, A3B, A2B2, AB3, and B4 - are found. A third isoform, C, and its tetramer, C4, are found in testis.

UnificationXref576
type: UnificationXref
id: REACT_157872
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_157872.3

peroxisomal matrix
type: CellularLocationVocabulary
xref: UnificationXref414

RelationshipXref372
type: RelationshipXref
id: GO:0097256
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence103
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/21550412
xref: http://identifiers.org/pubmed/18321209
xref: http://identifiers.org/pubmed/10727395
xref: http://identifiers.org/pubmed/17555404
comment: Tetrahydrobiopterin (BH4) is an essential co-factor for the aromatic amino acid hydroxylases and glycerol ether monooxygenase and it regulates nitric oxide synthase (NOS) activity. Inherited BH4 deficiency leads to hyperphenylalaninemia, and dopamine and neurotransmitter deficiency in the brain. BH4 maintains enzymatic coupling to L-arginine oxidation to produce NO. Oxidation of BH4 to BH2 results in NOS uncoupling, resulting in superoxide (O2.-) formation rather than NO. Superoxide rapidly reacts with NO to produce peroxynitrite which can further uncouple NOS. These reactive oxygen species (superoxide and peroxynitrite) can contribute to increased oxidative stress in the endothelium leading to atherosclerosis and hypertension (Thöny et al. 2000, Crabtree & Channon 2011, Schulz et al. 2008, Schmidt & Alp 2007). The synthesis, recycling and effects of BH4 are shown here. Three enzymes are required for the de novo biosynthesis of BH4 and two enzymes for the recycling of BH4.

RelationshipXref373
type: RelationshipXref
id: 4231158
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231158

Evidence104
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16722822
xref: http://identifiers.org/pubmed/12842859
comment: Originally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved in vascular smooth muscle cell proliferation, platelet aggregation, and leukocyte adhesion. Loss of the bioavailability of endothelium derived NO is a key feature of endothelial dysfunction and is implicated in the pathogenesis of cardiovascular disease such as hypertension and atherosclerosis. The endothelial isoform eNOS is unique among the nitric oxide synthase (NOS) family in that it is co-translationally modified at its amino terminus by myristoylation and is further acylated by palmitoylation (two residues next to the myristoylation site). These modifications target eNOS to the plasma membrane caveolae and lipid rafts. eNOS activation and subsequent nitric oxide (NO) production is stimulated by a variety of stimuli, such as fluid shear stress generated by blood flow, vascular endothelial growth factor (VEGF), bradykinin, estrogen, insulin, and angiopoietin. The activity of eNOS is further regulated by numerous post-translational modifications, including protein-protein interactions, phosphorylation, and subcellular localization. Following activation, eNOS shuttles between caveolae and other subcellular compartments such as the noncaveolar plasma membrane portions, Golgi apparatus, and perinuclear structures. This subcellular distribution is variable depending upon cell type and mode of activation. Subcellular localization of eNOS has a profound effect on its ability to produce NO as the availability of its substrates and cofactors will vary with location. eNOS is primarily particulate, and depending on the cell type, eNOS can be found in several membrane compartments: plasma membrane caveolae, lipid rafts, and intracellular membranes such as the Golgi complex. In addition, it has been reported that eNOS can also be detected in the nucleus, however, the conditions a…

UnificationXref570
type: UnificationXref
id: REACT_150881
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150881.1

RelationshipXref374
type: RelationshipXref
id: GO:0015171
db: GENE ONTOLOGY
relationship type: MI:0355

Evidence101
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/16722822
xref: http://identifiers.org/pubmed/12482742
xref: http://identifiers.org/pubmed/10551886
xref: http://identifiers.org/pubmed/11208594
comment: eNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localization. In general, following myristoylation and palmitoylation, eNOS localizes to caveolae in the plasma membrane, where in resting cells, it is bound to caveolin and remains inactive. Several agonists that raise intracellular calcium concentrations promote calmodulin binding to eNOS and the dissociation of caveolin from the enzyme, leading to an activated eNOS-calmodulin complex. Phosphorylation plays a significant role in regulating eNOS activity, especially the phosphorylation of Ser1177, located within the reductase domain, which increases enzyme activity by enhancing reductase activity and calcium sensitivity. In unstimulated, cultured endothelial cells, Ser1177 is rapidly phosphorylated following a variety of stimuli: fluid shear stress, insulin, estrogen, VEGF, or bradykinin. The kinases involved in this process depend upon the stimuli applied. For instance, shear stress phosphorylates Ser1177 by activating Akt and PKA; insulin activates both Akt and the AMP-activated protein kinase (AMPK); estrogen and VEGF mainly phosphorylate eNOS via Akt; whereas the bradykinin-induced phosphorylation of Ser1177 is mediated by CaMKII. When Ser1177 is phosphorylated, NO production is increased several-fold above basal levels. The phosphorylation of a threonine residue (Thr 495), located in the CaM binding domain, is associated with a decrease in eNOS activity. When this residue is dephosphorylated, substantially more CaM binds to eNOS and elevates enzyme activity. Stimuli associated with dephosphorylation of Thr495 (e.g., bradykinin, histamine, and Ca2+ ionophores) also increase Ca2+ levels resulting in the phosphorylation of Ser1177. Additional phosphorylation sites, such as Ser114 and Ser633, and tyrosine phosphorylation have all been detected, but their functional relevance re…

UnificationXref571
type: UnificationXref
id: 2161684
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161684

RelationshipXref375
type: RelationshipXref
id: 4230631
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230631

Evidence102
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/19666465
comment: In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

UnificationXref572
type: UnificationXref
id: REACT_150521
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150521.1

RelationshipXref371
type: RelationshipXref
id: GO:0051701
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref370
type: RelationshipXref
id: GO:0090382
db: GENE ONTOLOGY
relationship type: MI:0359

Evidence100
type: Evidence
evidence code: inferred from electronic annotation
xref: http://identifiers.org/pubmed/10559837
comment: Once depalmitoylated, it's proposed that eNOS is displaced from the plasma membrane and redistributed to other intracellular membranes, including the Golgi, where re-palmitoylation occurs. The mechanism of transport from the plasma membrane is still unknown.

UnificationXref59
type: UnificationXref
id: 113592
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592

UnificationXref58
type: UnificationXref
id: CHEBI:15422
db: ChEBI

UnificationXref569
type: UnificationXref
id: 2142751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142751

UnificationXref568
type: UnificationXref
id: CHEBI:63976
db: ChEBI

UnificationXref567
type: UnificationXref
id: REACT_150671
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_150671.1

UnificationXref566
type: UnificationXref
id: 2142749
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142749

UnificationXref53
type: UnificationXref
id: P99078
db: UniProt

D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
type: BiochemicalReaction
data source: Reactome
evidence: Evidence12
EC number: 2.7.1.11
xref: UnificationXref92
xref: UnificationXref93
left: SmallMolecule9
left: SmallMolecule8
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: D-Fructose 1,6-bisphosphate
right: Adenosine 5'-diphosphate

UnificationXref52
type: UnificationXref
id: REACT_2663
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2663.2

dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence13
EC number: 5.3.1.1
xref: UnificationXref115
xref: UnificationXref114
left: Dihydroxyacetone phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: D-Glyceraldehyde 3-phosphate

UnificationXref51
type: UnificationXref
id: 29512
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29512

1,3-Bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP
type: BiochemicalReaction
data source: Reactome
evidence: Evidence14
EC number: 2.7.2.3
xref: UnificationXref129
xref: UnificationXref128
left: (R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydridewith phosphoric propanoic acid
left: Adenosine 5'-diphosphate
display name: 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule9
right: 3-Phospho-D-glycerate

UnificationXref50
type: UnificationXref
id: CHEBI:15946
db: ChEBI

2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
type: BiochemicalReaction
data source: Reactome
evidence: Evidence15
EC number: 4.2.1.11
xref: UnificationXref143
xref: UnificationXref142
left: D-Glycerate 2-phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Water
right: Phosphoenolpyruvic acid

UnificationXref57
type: UnificationXref
id: REACT_87510
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_87510.9

UnificationXref56
type: UnificationXref
id: 4229794
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229794

Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
type: BiochemicalReaction
data source: Reactome
evidence: Evidence1
EC number: 1.14.13.39
xref: UnificationXref27
xref: UnificationXref28
left: SmallMolecule3
left: SmallMolecule1
left: SmallMolecule2
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule4
right: SmallMolecule5
right: SmallMolecule6

UnificationXref55
type: UnificationXref
id: 4229792
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229792

Glucose 6-phosphate is isomerized to form fructose-6-phosphate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence10
EC number: 5.3.1.9
xref: UnificationXref57
xref: UnificationXref56
left: SmallMolecule7
display name: alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule8

Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP
type: BiochemicalReaction
data source: Reactome
evidence: Evidence11
EC number: 2.7.1.105
xref: UnificationXref77
xref: UnificationXref78
left: SmallMolecule9
left: SmallMolecule8
display name: D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: D-Fructose 2,6-bisphosphate
right: Adenosine 5'-diphosphate

UnificationXref54
type: UnificationXref
id: 4229791
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229791

Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
type: BiochemicalReaction
data source: Reactome
evidence: Evidence18
EC number: 6.4.1.1
xref: UnificationXref197
xref: UnificationXref196
left: Carbon dioxide
left: Pyruvate
left: Adenosine 5'-triphosphate
display name: Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: Oxalacetic acid
right: Phosphate
right: Adenosine 5'-diphosphate

phosphoenolpyruvate + ADP => pyruvate + ATP
type: BiochemicalReaction
data source: Reactome
evidence: Evidence16
EC number: 2.7.1.40
xref: UnificationXref155
xref: UnificationXref154
left: Phosphoenolpyruvic acid
left: Adenosine 5'-diphosphate
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
right: SmallMolecule9
right: Pyruvate

UnificationXref60
type: UnificationXref
id: REACT_2812
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2812.1

RelationshipXref369
type: RelationshipXref
id: 4230912
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230912

RelationshipXref367
type: RelationshipXref
id: GO:0007603
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref564
type: UnificationXref
id: REACT_151621
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151621.1

RelationshipXref368
type: RelationshipXref
id: GO:0051139
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref565
type: UnificationXref
id: CHEBI:15550
db: ChEBI

RelationshipXref365
type: RelationshipXref
id: 4231209
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231209

UnificationXref562
type: UnificationXref
id: REACT_152334
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_152334.1

RelationshipXref366
type: RelationshipXref
id: GO:0001523
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref563
type: UnificationXref
id: 2161650
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2161650

RelationshipXref363
type: RelationshipXref
id: GO:0044281
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref560
type: UnificationXref
id: CHEBI:28442
db: ChEBI

RelationshipXref364
type: RelationshipXref
id: GO:0052650
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref561
type: UnificationXref
id: 2142799
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142799

RelationshipXref361
type: RelationshipXref
id: 4231191
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231191

RelationshipXref362
type: RelationshipXref
id: GO:0017144
db: GENE ONTOLOGY
relationship type: MI:0359

UnificationXref556
type: UnificationXref
id: REACT_159606
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_159606.3

UnificationXref555
type: UnificationXref
id: 4231169
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231169

UnificationXref558
type: UnificationXref
id: 2142721
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2142721

UnificationXref557
type: UnificationXref
id: CHEBI:15547
db: ChEBI

UnificationXref559
type: UnificationXref
id: REACT_151184
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_151184.1

UnificationXref69
type: UnificationXref
id: 4230066
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230066

UnificationXref66
type: UnificationXref
id: REACT_2510
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2510.1

UnificationXref65
type: UnificationXref
id: 30533
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30533

UnificationXref68
type: UnificationXref
id: 4230065
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230065

http://identifiers.org/pubmed/8302848
type: PublicationXref
id: 8302848
author: Cunningham, J
author: Johann, SV
author: Shows, TB
author: Eddy, R
author: van Zeijl, M
author: O'Hara, B
author: Closs, E
db: Pubmed
title: A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family
source: Proc Natl Acad Sci U S A 91:1168-72
year: 1994

UnificationXref67
type: UnificationXref
id: Q7A7J4
db: UniProt

UnificationXref62
type: UnificationXref
id: 29370
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370

UnificationXref61
type: UnificationXref
id: CHEBI:16761
db: ChEBI

UnificationXref64
type: UnificationXref
id: CHEBI:28602
db: ChEBI

UnificationXref63
type: UnificationXref
id: REACT_2741
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2741.1

UnificationXref70
type: UnificationXref
id: 4230067
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230067

UnificationXref71
type: UnificationXref
id: 4230068
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230068

Sphingolipid de novo biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction47
evidence: Evidence90
xref: RelationshipXref103
xref: UnificationXref672
xref: UnificationXref671
pathway order: PathwayStep86
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

RelationshipXref394
type: RelationshipXref
id: GO:0004822
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref395
type: RelationshipXref
id: 4230701
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230701

RelationshipXref396
type: RelationshipXref
id: GO:0004823
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref397
type: RelationshipXref
id: 4230711
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230711

UnificationXref550
type: UnificationXref
id: CHEBI:15553
db: ChEBI

RelationshipXref398
type: RelationshipXref
id: GO:0004824
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref551
type: UnificationXref
id: 879535
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=879535

RelationshipXref399
type: RelationshipXref
id: 4230743
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230743

UnificationXref552
type: UnificationXref
id: REACT_24606
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_24606.2

UnificationXref553
type: UnificationXref
id: Q7A3C6
db: UniProt

UnificationXref554
type: UnificationXref
id: 4231167
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231167

UnificationXref547
type: UnificationXref
id: CHEBI:15551
db: ChEBI

UnificationXref546
type: UnificationXref
id: REACT_127108
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127108.5

UnificationXref545
type: UnificationXref
id: 4231428
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231428

UnificationXref544
type: UnificationXref
id: REACT_136880
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_136880.5

RelationshipXref393
type: RelationshipXref
id: 4230753
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230753

http://identifiers.org/pubmed/19647993
type: PublicationXref
id: 19647993
author: Shental-Bechor, D
author: Levy, Y
db: Pubmed
title: Folding of glycoproteins: toward understanding the biophysics of the glycosylation code
source: Curr Opin Struct Biol 19:524-33
year: 2009

RelationshipXref392
type: RelationshipXref
id: 4230721
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230721

RelationshipXref391
type: RelationshipXref
id: GO:0004818
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref549
type: UnificationXref
id: REACT_15804
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15804.2

RelationshipXref390
type: RelationshipXref
id: 4230737
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230737

UnificationXref548
type: UnificationXref
id: 265287
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265287

http://identifiers.org/pubmed/8944226
type: PublicationXref
id: 8944226
author: Lehner, R
author: Kuksis, A
db: Pubmed
title: Biosynthesis of triacylglycerols
source: Prog Lipid Res 35:169-201
year: 1996

UnificationXref79
type: UnificationXref
id: 4230076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230076

UnificationXref78
type: UnificationXref
id: REACT_34412
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_34412.10

Disease
type: Pathway
data source: Reactome
pathway component: Diseases associated with visual transduction
pathway component: REACT 128820.5
pathway component: Latent infection of Homo sapiens with Mycobacterium tuberculosis
evidence: Evidence312
xref: UnificationXref2288
xref: UnificationXref2289
pathway order: PathwayStep305
pathway order: PathwayStep302
pathway order: PathwayStep304
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref77
type: UnificationXref
id: 4230075
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230075

UnificationXref76
type: UnificationXref
id: 4230073
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230073

UnificationXref75
type: UnificationXref
id: 4230072
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230072

UnificationXref74
type: UnificationXref
id: 4230071
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230071

UnificationXref73
type: UnificationXref
id: 4230070
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230070

UnificationXref72
type: UnificationXref
id: 4230069
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230069

UnificationXref81
type: UnificationXref
id: 30014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30014

UnificationXref82
type: UnificationXref
id: REACT_3740
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3740.1

UnificationXref80
type: UnificationXref
id: CHEBI:16905
db: ChEBI

RelationshipXref385
type: RelationshipXref
id: 4230685
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230685

RelationshipXref386
type: RelationshipXref
id: GO:0006418
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref383
type: RelationshipXref
id: GO:0007268
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref384
type: RelationshipXref
id: GO:0004820
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref389
type: RelationshipXref
id: GO:0004815
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref542
type: UnificationXref
id: REACT_127947
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127947.5

Golgi lumen
type: CellularLocationVocabulary
xref: UnificationXref2539

UnificationXref543
type: UnificationXref
id: 4231427
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231427

RelationshipXref387
type: RelationshipXref
id: GO:0004816
db: GENE ONTOLOGY
relationship type: MI:0355

UnificationXref540
type: UnificationXref
id: REACT_124023
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124023.1

RelationshipXref388
type: RelationshipXref
id: 4230731
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230731

UnificationXref541
type: UnificationXref
id: 4231155
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231155

Mevalonate-5-pyrophosphate
type: SmallMolecule
entity reference: (R)-5-Diphosphomevalonate [ChEBI:332]
data source: Reactome
xref: UnificationXref454
xref: UnificationXref455
cellular location: cytosol
comment: Reactome DB_ID: 191403
display name: MVA5PP

UnificationXref482
type: UnificationXref
id: 428686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=428686

delta3-isopentenyl pyrophosphate
type: SmallMolecule
entity reference: delta3-methyl-3-butenyl diphosphate
data source: Reactome
xref: UnificationXref458
xref: UnificationXref457
cellular location: cytosol
comment: Reactome DB_ID: 191362
display name: IPPP

UnificationXref481
type: UnificationXref
id: CHEBI:17553
db: ChEBI

Mevalonate
type: SmallMolecule
entity reference: 3,5-Dihydroxy-3-methylvaleric acid
data source: Reactome
xref: UnificationXref444
xref: UnificationXref443
cellular location: cytosol
comment: Reactome DB_ID: 191424
display name: MVA

UnificationXref484
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Mevalonate-5-phosphate
type: SmallMolecule
entity reference: CHEBI:17436
data source: Reactome
xref: UnificationXref447
xref: UnificationXref446
cellular location: cytosol
comment: Reactome DB_ID: 191296
display name: MVA5P

UnificationXref483
type: UnificationXref
id: REACT_20211
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_20211.2

ChEBI:29179 tRNA(Ser)
type: SmallMoleculeReference
name: tRNA(Ser)
xref: UnificationXref2461

3-hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
entity reference: HMG-CoA
data source: Reactome
name: beta-hydroxy-beta-methylglutaryl-CoA
name: bHMG-CoA
xref: UnificationXref436
xref: UnificationXref435
cellular location: cytosol
comment: Reactome DB_ID: 191374
display name: HMG-CoA

UnificationXref486
type: UnificationXref
id: REACT_5335
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5335.1

coenzyme A
type: SmallMolecule
entity reference: CoA-SH
data source: Reactome
xref: UnificationXref438
xref: UnificationXref437
cellular location: cytosol
comment: Reactome DB_ID: 76194
display name: CoA-SH

UnificationXref485
type: UnificationXref
id: 110614
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110614

UnificationXref488
type: UnificationXref
id: 1500603
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1500603

UnificationXref487
type: UnificationXref
id: CHEBI:16732
db: ChEBI

tRNA(Glu)
type: SmallMoleculeReference
name: ChEBI:29175 tRNA(Glu)
xref: UnificationXref2364

tRNA(Ile)
type: SmallMoleculeReference
name: ChEBI:29174 tRNA(Ile)
xref: UnificationXref2384

tRNA(Pro)
type: SmallMoleculeReference
name: ChEBI:29177 tRNA(Pro)
xref: UnificationXref2448

tRNA(Gly)
type: SmallMoleculeReference
name: ChEBI:29176 tRNA(Gly)
xref: UnificationXref2325

ChEBI:29173 tRNA(Met)
type: SmallMoleculeReference
name: tRNA(Met)
xref: UnificationXref2425

UnificationXref480
type: UnificationXref
id: REACT_142911
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_142911.5

tRNA(Asn)
type: SmallMoleculeReference
name: ChEBI:29172 tRNA(Asn)
xref: UnificationXref2341

http://identifiers.org/pubmed/10745013
type: PublicationXref
id: 10745013
author: Gover, S
author: Lam, VM
author: Au, SW
author: Adams, MJ
db: Pubmed
title: Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency
source: Structure 8:293-303
year: 2000

The citric acid (TCA) cycle and respiratory electron transport
type: Pathway
data source: Reactome
pathway component: Pyruvate metabolism and Citric Acid (TCA) cycle
evidence: Evidence119
xref: UnificationXref879
xref: RelationshipXref131
xref: UnificationXref878
pathway order: PathwayStep115
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UniProt:P60298
type: ProteinReference
xref: UnificationXref1609
organism: BioSource1

UniProt:P60296
type: ProteinReference
xref: UnificationXref1612
organism: BioSource1

UnificationXref489
type: UnificationXref
id: REACT_124825
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_124825.1

cytidine 5'-triphosphate
type: SmallMolecule
entity reference: cytidine 5'-triphosphate
data source: Reactome
name: Cytidine triphosphate
xref: UnificationXref485
xref: UnificationXref486
cellular location: cytosol
comment: Reactome DB_ID: 110614
display name: CTP

ethanolamine phosphate
type: SmallMolecule
entity reference: CHEBI:17553
data source: Reactome
name: phosphoethanolamine
xref: UnificationXref482
xref: UnificationXref483
cellular location: cytosol
comment: Reactome DB_ID: 428686
display name: PETA

Cortisone
type: SmallMolecule
entity reference: 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
data source: Reactome
xref: UnificationXref471
xref: UnificationXref470
cellular location: cytosol
comment: Reactome DB_ID: 194035
display name: COR

Cortisol
type: SmallMolecule
entity reference: Kendall's compound F
data source: Reactome
xref: UnificationXref468
xref: UnificationXref467
cellular location: cytosol
comment: Reactome DB_ID: 193977
display name: CORT

UnificationXref495
type: UnificationXref
id: 4231122
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231122

Choline
type: SmallMolecule
entity reference: Choline
data source: Reactome
xref: UnificationXref505
xref: UnificationXref504
cellular location: extracellular region
comment: Reactome DB_ID: 264638
display name: Cho

UnificationXref494
type: UnificationXref
id: 4231121
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231121

acetate
type: SmallMolecule
entity reference: acetic acid, ion(1-)
data source: Reactome
xref: UnificationXref507
xref: UnificationXref508
cellular location: extracellular region
comment: Reactome DB_ID: 1524044

UnificationXref493
type: UnificationXref
id: Q7A710
db: UniProt

Phosphocholine
type: SmallMolecule
entity reference: CHEBI:36700
data source: Reactome
xref: UnificationXref517
xref: UnificationXref518
cellular location: cytosol
comment: Reactome DB_ID: 1524071
display name: PCho

UnificationXref492
type: UnificationXref
id: REACT_5692
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5692.2

CDP-choline
type: SmallMolecule
entity reference: Cytidine 5'-diphosphocholine
data source: Reactome
xref: UnificationXref520
xref: UnificationXref521
cellular location: cytosol
comment: Reactome DB_ID: 1524060
display name: CDP-Cho

UnificationXref499
type: UnificationXref
id: REACT_135063
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_135063.5

CDP-ethanolamine
type: SmallMolecule
entity reference: CDPethanolamine [ChEBI:3270]
data source: Reactome
xref: UnificationXref489
xref: UnificationXref488
cellular location: cytosol
comment: Reactome DB_ID: 1500603
display name: CDP-ETA

UnificationXref498
type: UnificationXref
id: 4231418
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231418

diphosphate
type: SmallMolecule
entity reference: CHEBI:29888
data source: Reactome
name: pyrophosphoric acid
name: pyrophosphate
xref: UnificationXref491
xref: UnificationXref492
cellular location: cytosol
comment: Reactome DB_ID: 111294
display name: PPi

UnificationXref497
type: UnificationXref
id: REACT_146145
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_146145.5

UnificationXref496
type: UnificationXref
id: 4231124
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231124

O-acetylcholine
type: SmallMolecule
entity reference: ChEBI:15355 O-acetylcholine
data source: Reactome
xref: UnificationXref501
xref: UnificationXref502
cellular location: extracellular region
comment: Reactome DB_ID: 372533
display name: AcCho

tRNA(Asp)
type: SmallMoleculeReference
name: ChEBI:29186 tRNA(Asp)
xref: UnificationXref2351

tRNA(Lys)
type: SmallMoleculeReference
name: ChEBI:29185 tRNA(Lys)
xref: UnificationXref2413

tRNA(Phe)
type: SmallMoleculeReference
name: ChEBI:29184 tRNA(Phe)
xref: UnificationXref2438

UnificationXref491
type: UnificationXref
id: 111294
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111294

UnificationXref490
type: UnificationXref
id: CHEBI:29888
db: ChEBI

tRNA(Tyr)
type: SmallMoleculeReference
name: ChEBI:29182 tRNA(Tyr)
xref: UnificationXref2490

tRNA(Trp)
type: SmallMoleculeReference
name: ChEBI:29181 tRNA(Trp)
xref: UnificationXref2475

4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl-CoA
type: SmallMolecule
entity reference: CHEBI:65132
data source: Reactome
xref: UnificationXref540
xref: UnificationXref539
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 2066765
display name: DHA-CoA

1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA
type: SmallMolecule
entity reference: CHEBI:65131
data source: Reactome
xref: UnificationXref536
xref: UnificationXref537
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 2066762
display name: 1-3-oxo-THA-CoA

Prostaglandin E2
type: SmallMolecule
entity reference: Prostaglandin E2 [ChEBI:8512]
data source: Reactome
xref: UnificationXref549
xref: UnificationXref548
cellular location: cytosol
comment: Reactome DB_ID: 265287
display name: PGE2

Glu-tRNA(Glu)
type: SmallMoleculeReference
name: ChEBI:29157 Glu-tRNA(Glu)
xref: UnificationXref2367

UnificationXref464
type: UnificationXref
id: 4231322
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231322

ChEBI:29156 Gly-tRNA(Gly)
type: SmallMoleculeReference
name: Gly-tRNA(Gly)
xref: UnificationXref2328

UnificationXref463
type: UnificationXref
id: REACT_81926
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_81926.9

ChEBI:29159 Trp-tRNA(Trp)
type: SmallMoleculeReference
name: Trp-tRNA(Trp)
xref: UnificationXref2481

UnificationXref466
type: UnificationXref
id: CHEBI:17650
db: ChEBI

ChEBI:29158 Asp-tRNA(Asp)
type: SmallMoleculeReference
name: Asp-tRNA(Asp)
xref: UnificationXref2356

UnificationXref465
type: UnificationXref
id: REACT_84026
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_84026.9

UnificationXref460
type: UnificationXref
id: 4230499
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230499

UnificationXref462
type: UnificationXref
id: 4230502
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230502

UnificationXref461
type: UnificationXref
id: 4230500
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230500

ChEBI:29153 Phe-tRNA(Phe)
type: SmallMoleculeReference
name: Phe-tRNA(Phe)
xref: UnificationXref2441

http://identifiers.org/pubmed/18690016
type: PublicationXref
id: 18690016
author: Schnetkamp, PP
author: Altimimi, HF
db: Pubmed
title: Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
source: Channels (Austin) 1:62-9
year: 2007

Pro-tRNA(Pro)
type: SmallMoleculeReference
name: ChEBI:29154 Pro-tRNA(Pro)
xref: UnificationXref2454

http://identifiers.org/pubmed/12473340
type: PublicationXref
id: 12473340
author: Dyson, NJ
author: Stevaux, O
db: Pubmed
title: A revised picture of the E2F transcriptional network and RB function.
source: Curr Opin Cell Biol 14:684-91
year: 2002

Amine compound SLC transporters
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction239
pathway component: BiochemicalReaction240
evidence: Evidence431
xref: UnificationXref3006
xref: UnificationXref3007
pathway order: PathwayStep377
pathway order: PathwayStep378
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref467
type: UnificationXref
id: 193977
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=193977

UnificationXref468
type: UnificationXref
id: REACT_10255
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10255.2

UnificationXref469
type: UnificationXref
id: CHEBI:16962
db: ChEBI

UnificationXref477
type: UnificationXref
id: 4231325
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231325

ChEBI:29169 tRNA(Leu)
type: SmallMoleculeReference
name: tRNA(Leu)
xref: UnificationXref2397

UnificationXref476
type: UnificationXref
id: REACT_128262
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_128262.5

UnificationXref475
type: UnificationXref
id: 4230518
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230518

UnificationXref474
type: UnificationXref
id: 4230516
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230516

UnificationXref473
type: UnificationXref
id: 4230515
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230515

UnificationXref472
type: UnificationXref
id: Q7A5G9
db: UniProt

UnificationXref471
type: UnificationXref
id: REACT_10200
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_10200.2

UnificationXref470
type: UnificationXref
id: 194035
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194035

Ser-tRNA(Ser)
type: SmallMoleculeReference
name: ChEBI:29162 Ser-tRNA(Ser)
xref: UnificationXref2467

Tyr-tRNA(Tyr)
type: SmallMoleculeReference
name: ChEBI:29161 Tyr-tRNA(Tyr)
xref: UnificationXref2493

Ile-tRNA(Ile)
type: SmallMoleculeReference
name: ChEBI:29160 Ile-tRNA(Ile)
xref: UnificationXref2390

Pb
type: SmallMoleculeReference
name: ChEBI:6397 Pb2+
name: Lead
name: Pb2+
xref: UnificationXref1973

http://identifiers.org/pubmed/18391176
type: PublicationXref
id: 18391176
author: Qu, Zhiqiang
author: Xiao, Qinghuan
author: Chien, Li-Ting
author: Hartzell, H Criss
author: Yu, Kuai
db: Pubmed
title: Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies
source: Physiol. Rev. 88:639-72
year: 2008

UnificationXref478
type: UnificationXref
id: REACT_127140
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_127140.5

http://identifiers.org/pubmed/15265857
type: PublicationXref
id: 15265857
author: Lombardo, D
author: Aubert-Jousset, E
author: Sbarra, V
db: Pubmed
title: Site-directed mutagenesis of the distal basic cluster of pancreatic bile salt-dependent lipase
source: J Biol Chem 279:39697-704
year: 2004

UnificationXref479
type: UnificationXref
id: 4231326
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231326

RelationshipXref402
type: RelationshipXref
id: GO:0004826
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref403
type: RelationshipXref
id: 4230716
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230716

RelationshipXref404
type: RelationshipXref
id: GO:0004827
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref405
type: RelationshipXref
id: 4230706
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230706

RelationshipXref406
type: RelationshipXref
id: GO:0004828
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref407
type: RelationshipXref
id: 4230749
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230749

RelationshipXref408
type: RelationshipXref
id: GO:0004830
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref409
type: RelationshipXref
id: 4230726
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230726

D-Glucono-1,5-lactone 6-phosphate
type: SmallMolecule
entity reference: 6-Phospho-D-glucono-1,5-lactone
data source: Reactome
xref: UnificationXref238
xref: UnificationXref237
cellular location: cytosol
comment: Reactome DB_ID: 31467
display name: 6-Phospho-D-glucono-1,5-lactone

DPN
type: SmallMolecule
entity reference: NAD
data source: Reactome
name: Diphosphopyridine nucleotide
name: NAD+
name: Nicotinamide adenine dinucleotide
xref: UnificationXref228
xref: UnificationXref227
cellular location: cytosol
comment: Reactome DB_ID: 29360
display name: NAD

RelationshipXref400
type: RelationshipXref
id: GO:0004825
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref401
type: RelationshipXref
id: 4230690
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230690

2'-deoxyadenosine 5'-triphosphate
type: SmallMolecule
entity reference: CHEBI:16284
data source: Reactome
xref: UnificationXref285
xref: UnificationXref284
cellular location: cytosol
comment: Reactome DB_ID: 110644
display name: dATP

deoxyadenylic acid
type: SmallMolecule
entity reference: 2'-deoxyadenosine 5'-monophosphate [ChEBI:17713]
data source: Reactome
name: 2'-Deoxyadenosine 5'-phosphate
name: Deoxyadenosine monophosphate
name: 2'-deoxyadenosine 5'-monophosphate
xref: UnificationXref288
xref: UnificationXref287
cellular location: cytosol
comment: Reactome DB_ID: 109386
display name: dAMP

D-Xylulose 5-phosphate
type: SmallMolecule
entity reference: D-Xylulose 5-phosphate
data source: Reactome
xref: UnificationXref263
xref: UnificationXref264
cellular location: cytosol
comment: Reactome DB_ID: 29790
display name: XY5P

D-ribose 5-phosphate
type: SmallMolecule
entity reference: D-ribose 5-phosphate
data source: Reactome
name: Ribose 5-phosphate
xref: UnificationXref274
xref: UnificationXref273
cellular location: cytosol
comment: Reactome DB_ID: 73578
display name: R5P

Carbon dioxide
type: SmallMolecule
entity reference: CO2 [ChEBI:16526]
data source: Reactome
xref: UnificationXref252
xref: UnificationXref253
cellular location: cytosol
comment: Reactome DB_ID: 113528
display name: CO2

D-Ribulose 5-phosphate
type: SmallMolecule
entity reference: CHEBI:17363
data source: Reactome
xref: UnificationXref255
xref: UnificationXref256
cellular location: cytosol
comment: Reactome DB_ID: 29732
display name: RU5P

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref241
xref: UnificationXref240
cellular location: cytosol
comment: Reactome DB_ID: 70106
display name: H+

6-Phospho-D-gluconate
type: SmallMolecule
entity reference: 6-Phospho-D-gluconate [ChEBI:16863]
data source: Reactome
xref: UnificationXref251
xref: UnificationXref250
cellular location: cytosol
comment: Reactome DB_ID: 29996
display name: PDG

http://identifiers.org/pubmed/17916383
type: PublicationXref
id: 17916383
author: Turunen, M
author: Swiezewska, E
author: Chojnacki, T
author: Dallner, G
author: Tekle, M
db: Pubmed
title: Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells
source: J Biochem Biophys Methods 70:909-17
year: 2008

12-Keto-leukotriene B4
type: SmallMoleculeReference
name: 12-Keto-leukotriene B4 [ChEBI:742]
name: 5-Hydroxy-12-oxo-delta5,8,11,14-eicosapolyenoic acid
name: 12-Keto-LTB4
xref: UnificationXref582

RelationshipXref415
type: RelationshipXref
id: 4230795
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230795

RelationshipXref416
type: RelationshipXref
id: 4230822
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230822

RelationshipXref413
type: RelationshipXref
id: GO:0015385
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref414
type: RelationshipXref
id: 4230813
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230813

RelationshipXref419
type: RelationshipXref
id: 4230843
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230843

RelationshipXref417
type: RelationshipXref
id: 4230790
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230790

RelationshipXref418
type: RelationshipXref
id: GO:0015321
db: GENE ONTOLOGY
relationship type: MI:0355

5-Phosphoribosyl 1-pyrophosphate
type: SmallMolecule
entity reference: CHEBI:17111
data source: Reactome
name: 5-Phosphoribosyl diphosphate
name: 5-phospho-alpha-D-ribose 1-diphosphate
xref: UnificationXref291
xref: UnificationXref290
cellular location: cytosol
comment: Reactome DB_ID: 73566
display name: PRPP

cholesterol esters
type: SmallMolecule
entity reference: CHEBI:17002
data source: Reactome
xref: UnificationXref311
xref: UnificationXref310
cellular location: extracellular region
comment: Reactome DB_ID: 171076
display name: CHEST

http://identifiers.org/pubmed/17374283
type: PublicationXref
id: 17374283
author: Wang, JP
author: Hou, XH
db: Pubmed
title: Expression of aquaporin 8 in colonic epithelium with diarrhoea-predominant irritable bowel syndrome
source: Chin Med J (Engl) 120:313-6
year: 2007

water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref307
xref: UnificationXref308
cellular location: extracellular region
comment: Reactome DB_ID: 109276
display name: H2O

RelationshipXref411
type: RelationshipXref
id: 4230696
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230696

RelationshipXref412
type: RelationshipXref
id: GO:0010467
db: GENE ONTOLOGY
relationship type: MI:0359

http://identifiers.org/pubmed/9990024
type: PublicationXref
id: 9990024
author: Nerlich, A
author: Reiss, J
author: Mendel, RR
author: Kirsch, J
author: Schulze, J
author: Schwarz, G
author: Stallmeyer, B
db: Pubmed
title: The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells
source: Proc Natl Acad Sci U S A 96:1333-8
year: 1999

RelationshipXref410
type: RelationshipXref
id: GO:0004831
db: GENE ONTOLOGY
relationship type: MI:0355

glycocholate
type: SmallMolecule
entity reference: Glycocholate [ChEBI:17687]
data source: Reactome
xref: UnificationXref322
xref: UnificationXref323
cellular location: extracellular region
comment: Reactome DB_ID: 192464

taurocholate
type: SmallMolecule
entity reference: Taurocholate [ChEBI:9408]
data source: Reactome
xref: UnificationXref325
xref: UnificationXref326
cellular location: extracellular region
comment: Reactome DB_ID: 192421

chenodeoxycholate
type: SmallMolecule
entity reference: Chenodeoxycholate [ChEBI:16755]
data source: Reactome
xref: UnificationXref328
xref: UnificationXref329
cellular location: extracellular region
comment: Reactome DB_ID: 192442

long-chain fatty acids
type: SmallMolecule
entity reference: CHEBI:15904
data source: Reactome
xref: UnificationXref313
xref: UnificationXref314
cellular location: extracellular region
comment: Reactome DB_ID: 174602
display name: LCFAs

cholesterol
type: SmallMolecule
entity reference: cholest-5-en-3beta-ol
data source: Reactome
xref: UnificationXref317
xref: UnificationXref316
cellular location: extracellular region
comment: Reactome DB_ID: 171149
display name: CHOL

bile salts and acids
type: SmallMolecule
data source: Reactome
member physical entity: glycochenodeoxycholate
member physical entity: cholate
member physical entity: taurochenodeoxycholate
member physical entity: taurocholate
member physical entity: chenodeoxycholate
member physical entity: glycocholate
xref: UnificationXref336
xref: UnificationXref337
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 192483

cholate
type: SmallMolecule
entity reference: Cholate
data source: Reactome
xref: UnificationXref319
xref: UnificationXref320
cellular location: extracellular region
comment: Reactome DB_ID: 192431

RelationshipXref428
type: RelationshipXref
id: GO:0005314
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref429
type: RelationshipXref
id: 4230846
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230846

RelationshipXref424
type: RelationshipXref
id: 4230678
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230678

RelationshipXref425
type: RelationshipXref
id: 4230672
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230672

RelationshipXref426
type: RelationshipXref
id: 4230675
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230675

RelationshipXref427
type: RelationshipXref
id: GO:0006865
db: GENE ONTOLOGY
relationship type: MI:0359

RelationshipXref420
type: RelationshipXref
id: 4230838
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230838

RelationshipXref421
type: RelationshipXref
id: 4230833
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230833

RelationshipXref422
type: RelationshipXref
id: 4230653
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230653

http://identifiers.org/pubmed/21377628
type: PublicationXref
id: 21377628
author: Guymer, Robyn H
author: Fletcher, Erica L
author: Vessey, Kirstan A
author: Baird, Paul N
author: Luu, Chi
author: Jobling, Andrew I
db: Pubmed
title: Animal models of retinal disease
source: Prog Mol Biol Transl Sci 100:211-86
year: 2011

RelationshipXref423
type: RelationshipXref
id: 4230659
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230659

glycerol
type: SmallMolecule
entity reference: 1,2,3-Propanetriol
data source: Reactome
xref: UnificationXref349
xref: UnificationXref348
cellular location: extracellular region
comment: Reactome DB_ID: 192438
display name: Glycerol

2-Monoacylglycerol
type: SmallMolecule
entity reference: CHEBI:17389
data source: Reactome
name: 2-MAG
name: 2-acylglycerols
xref: UnificationXref346
xref: UnificationXref345
cellular location: extracellular region
comment: Reactome DB_ID: 192457
display name: 2AGs

taurochenodeoxycholate
type: SmallMolecule
entity reference: Taurochenodeoxycholate [ChEBI:9407]
data source: Reactome
xref: UnificationXref334
xref: UnificationXref335
cellular location: extracellular region
comment: Reactome DB_ID: 192415

glycochenodeoxycholate
type: SmallMolecule
entity reference: CHEBI:36274
data source: Reactome
xref: UnificationXref331
xref: UnificationXref332
cellular location: extracellular region
comment: Reactome DB_ID: 192473

Glycerol
type: SmallMolecule
entity reference: 1,2,3-Propanetriol
data source: Reactome
xref: UnificationXref364
xref: UnificationXref365
cellular location: cytosol
comment: Reactome DB_ID: 76116

Glycerol-3-phosphate
type: SmallMolecule
entity reference: CHEBI:15978
data source: Reactome
xref: UnificationXref368
xref: UnificationXref367
cellular location: cytosol
comment: Reactome DB_ID: 76114
display name: G3P

triacylglycerols
type: SmallMolecule
entity reference: triglyceride
data source: Reactome
xref: UnificationXref354
xref: UnificationXref353
cellular location: extracellular region
comment: Reactome DB_ID: 171126
display name: TAGs

diacylglycerols
type: SmallMolecule
entity reference: diacylglycerols
data source: Reactome
xref: UnificationXref357
xref: UnificationXref356
cellular location: extracellular region
comment: Reactome DB_ID: 174675
display name: DAG

acetoacetyl-CoA
type: SmallMolecule
entity reference: Acetoacetyl coenzyme A
data source: Reactome
xref: UnificationXref377
xref: UnificationXref376
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 73871
display name: ACA-CoA

Coenzyme A
type: SmallMolecule
entity reference: CoA-SH
data source: Reactome
name: CoA-SH
xref: UnificationXref379
xref: UnificationXref380
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 29374
display name: CoA

RelationshipXref439
type: RelationshipXref
id: GO:0008028
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref437
type: RelationshipXref
id: GO:0022803
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref438
type: RelationshipXref
id: 4230872
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230872

RelationshipXref435
type: RelationshipXref
id: GO:0008507
db: GENE ONTOLOGY
relationship type: MI:0355

RelationshipXref436
type: RelationshipXref
id: 4230866
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230866

RelationshipXref433
type: RelationshipXref
id: 4230860
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230860

RelationshipXref434
type: RelationshipXref
id: 4230863
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230863

RelationshipXref431
type: RelationshipXref
id: 4230854
db: Reactome Database ID Release 45
relationship type: RelationshipTypeVocabulary2
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230854

beta-Hydroxy-beta-methylglutaryl coenzyme A
type: SmallMolecule
entity reference: HMG-CoA
data source: Reactome
xref: UnificationXref383
xref: UnificationXref382
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 73917
display name: HMG CoA

http://identifiers.org/pubmed/7391027
type: PublicationXref
id: 7391027
author: Welch, CD
author: Huang, IY
author: Yoshida, A
db: Pubmed
title: Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.
source: J Biol Chem 255:6412-20
year: 1980

RelationshipXref432
type: RelationshipXref
id: GO:0015538
db: GENE ONTOLOGY
relationship type: MI:0355

Glycerol-3-phosphate
type: SmallMolecule
entity reference: CHEBI:15978
data source: Reactome
xref: UnificationXref396
xref: UnificationXref395
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 188458
display name: G3P

RelationshipXref430
type: RelationshipXref
id: GO:0005313
db: GENE ONTOLOGY
relationship type: MI:0355

Flavin adenine dinucleotide
type: SmallMolecule
entity reference: CHEBI:16238
data source: Reactome
xref: UnificationXref393
xref: UnificationXref394
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113596
display name: FAD

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate
data source: Reactome
name: Glycerone phosphate
xref: UnificationXref401
xref: UnificationXref400
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 188451
display name: DHAP

FADH2
type: SmallMolecule
entity reference: FADH2
data source: Reactome
xref: UnificationXref399
xref: UnificationXref398
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 31649

CoA-SH
type: SmallMolecule
entity reference: CoA-SH
data source: Reactome
xref: UnificationXref415
xref: UnificationXref416
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 193514

3-ketohexacosanoyl-CoA
type: SmallMolecule
entity reference: 3-oxohexacosanoyl-CoA [ChEBI:52977]
data source: Reactome
xref: UnificationXref418
xref: UnificationXref419
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 390241

Acetyl coenzyme A
type: SmallMolecule
entity reference: Acetyl coenzyme A
data source: Reactome
name: Acetyl-CoA
xref: UnificationXref421
xref: UnificationXref420
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 353123
display name: Ac-CoA

tetracosanoyl-CoA
type: SmallMolecule
entity reference: tetracosanoyl-CoA
data source: Reactome
xref: UnificationXref423
xref: UnificationXref424
cellular location: peroxisomal matrix
comment: Reactome DB_ID: 390246
display name: lignoceryl-CoA

acetoacetyl-CoA
type: SmallMolecule
entity reference: Acetoacetyl coenzyme A
data source: Reactome
xref: UnificationXref434
xref: UnificationXref433
cellular location: cytosol
comment: Reactome DB_ID: 191293
display name: ACA-CoA

http://identifiers.org/pubmed/10698697
type: PublicationXref
id: 10698697
author: Broer, Stefan
author: Wagner, CA
author: Lang, F
author: Broer, Angelika
db: Pubmed
title: Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance
source: Biochem J 346:705-10
year: 2000

http://identifiers.org/pubmed/3182820
type: PublicationXref
id: 3182820
author: Nelson, T
author: Kaufman, EE
author: Levin, DM
author: Fales, HM
db: Pubmed
title: Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria
source: J Biol Chem 263:16872-9
year: 1988

http://identifiers.org/pubmed/9177788
type: PublicationXref
id: 9177788
author: Reiter, L T
author: Lupski, J R
author: Murakami, T
db: Pubmed
title: Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene
source: Genomics 42:161-4
year: 1997

UniProt:Q99UZ7
type: ProteinReference
xref: UnificationXref2268
organism: BioSource1

Mg++
type: SmallMolecule
entity reference: CHEBI:18420
data source: Reactome
name: Magnesium
xref: UnificationXref124
xref: UnificationXref123
cellular location: cytosol
comment: Reactome DB_ID: 29926
display name: Mg2+

3-Phospho-D-glycerate
type: SmallMolecule
entity reference: 3-Phospho-D-glycerate
data source: Reactome
name: D-Glycerate 3-phosphate
xref: UnificationXref121
xref: UnificationXref120
cellular location: cytosol
comment: Reactome DB_ID: 29728
display name: 3PG

(R)-2-Hydroxy-3-(phosphonooxy)-1-monoanhydridewith phosphoric propanoic acid
type: SmallMolecule
entity reference: CHEBI:16001
data source: Reactome
name: 3-Phospho-D-glyceroyl phosphate
xref: UnificationXref118
xref: UnificationXref117
cellular location: cytosol
comment: Reactome DB_ID: 29800
display name: 1,3-Bisphospho-D-glycerate

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: D-Glyceraldehyde 3-phosphate
data source: Reactome
name: (2R)-2-Hydroxy-3-(phosphonooxy)-propanal
xref: UnificationXref109
xref: UnificationXref110
cellular location: cytosol
comment: Reactome DB_ID: 29578
display name: GA3P

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate
data source: Reactome
name: Glycerone phosphate
xref: UnificationXref107
xref: UnificationXref106
cellular location: cytosol
comment: Reactome DB_ID: 75970
display name: DHAP

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Reactome
xref: UnificationXref103
xref: UnificationXref104
cellular location: cytosol
comment: Reactome DB_ID: 76190
display name: CIT

5'-Adenylic acid
type: SmallMolecule
entity reference: CHEBI:16027
data source: Reactome
name: Adenylate
name: Adenosine 5'-phosphate
name: 5'-AMP
name: 5'-Adenosine monophosphate
name: adenosine 5'-monophosphate
name: Adenylic acid
xref: UnificationXref96
xref: UnificationXref97
cellular location: cytosol
comment: Reactome DB_ID: 76577
display name: AMP

D-Fructose 1,6-bisphosphate
type: SmallMolecule
entity reference: D-Fructose 1,6-bisphosphate
data source: Reactome
xref: UnificationXref81
xref: UnificationXref82
cellular location: cytosol
comment: Reactome DB_ID: 30014

D-Fructose 2,6-bisphosphate
type: SmallMolecule
entity reference: D-Fructose 2,6-bisphosphate [ChEBI:28602]
data source: Reactome
xref: UnificationXref66
xref: UnificationXref65
cellular location: cytosol
comment: Reactome DB_ID: 30533

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref63
xref: UnificationXref62
cellular location: cytosol
comment: Reactome DB_ID: 29370
display name: ADP

Proline catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction143
evidence: Evidence226
xref: RelationshipXref276
xref: UnificationXref1752
xref: UnificationXref1753
pathway order: PathwayStep222
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Carbon dioxide
type: SmallMolecule
entity reference: CO2 [ChEBI:16526]
data source: Reactome
xref: UnificationXref176
xref: UnificationXref175
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 29376
display name: CO2

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref173
xref: UnificationXref172
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113593
display name: ATP

Water
type: SmallMolecule
entity reference: H2O
data source: Reactome
xref: UnificationXref134
xref: UnificationXref135
cellular location: cytosol
comment: Reactome DB_ID: 29356
display name: H2O

D-Glycerate 2-phosphate
type: SmallMolecule
entity reference: D-Glycerate 2-phosphate
data source: Reactome
name: 2-Phospho-D-glycerate
xref: UnificationXref131
xref: UnificationXref132
cellular location: cytosol
comment: Reactome DB_ID: 30485
display name: 2PG

Pyruvate
type: SmallMolecule
entity reference: Pyruvate
data source: Reactome
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref146
xref: UnificationXref145
cellular location: cytosol
comment: Reactome DB_ID: 29398
display name: PYR

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid
data source: Reactome
name: Phosphoenolpyruvate
xref: UnificationXref138
xref: UnificationXref137
cellular location: cytosol
comment: Reactome DB_ID: 29492
display name: PEP

Adenosine 5'-triphosphate
type: SmallMolecule
entity reference: Adenosine 5'-triphosphate
data source: Reactome
xref: UnificationXref159
xref: UnificationXref158
cellular location: nucleoplasm
comment: Reactome DB_ID: 29358
display name: ATP

Potassium
type: SmallMolecule
entity reference: K+
data source: Reactome
xref: UnificationXref150
xref: UnificationXref149
cellular location: cytosol
comment: Reactome DB_ID: 29804
display name: K+

Acetyl coenzyme A
type: SmallMolecule
entity reference: Acetyl coenzyme A
data source: Reactome
name: Acetyl-CoA
xref: UnificationXref167
xref: UnificationXref168
cellular location: cytosol
comment: Reactome DB_ID: 76183
display name: Ac-CoA

Cyclic AMP
type: SmallMolecule
entity reference: CHEBI:17489
data source: Reactome
name: Cyclic adenylic acid
name: Adenosine 3',5'-phosphate
name: 3',5'-Cyclic AMP
xref: UnificationXref164
xref: UnificationXref163
cellular location: cytosol
comment: Reactome DB_ID: 30389
display name: cAMP

http://identifiers.org/pubmed/20576942
type: PublicationXref
id: 20576942
author: Kühl, Michael
author: Rao, Tata Purushothama
db: Pubmed
title: An updated overview on Wnt signaling pathways: a prelude for more
source: Circ. Res. 106:1798-806
year: 2010

UDPglucose
type: SmallMolecule
entity reference: UDPglucose
data source: Reactome
name: UDP-D-glucose
name: UDP-glucose
xref: UnificationXref224
xref: UnificationXref225
cellular location: cytosol
comment: Reactome DB_ID: 29410
display name: UDP-Glc

NH4+
type: SmallMoleculeReference
name: NH4+ [ChEBI:28938]
xref: UnificationXref1023

Metabolism of porphyrins
type: Pathway
data source: Reactome
pathway component: Heme biosynthesis
evidence: Evidence269
xref: RelationshipXref340
xref: UnificationXref2063
xref: UnificationXref2062
pathway order: PathwayStep265
display name: Porphyrin metabolism
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Coenzyme R
type: SmallMolecule
entity reference: CHEBI:15956
data source: Reactome
name: D-Biotin
name: Biotin
name: Vitamin H
xref: UnificationXref190
xref: UnificationXref191
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 29582
display name: Btn

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
xref: UnificationXref185
xref: UnificationXref186
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113548
display name: Pi

Adenosine 5'-diphosphate
type: SmallMolecule
entity reference: ADP [ChEBI:16761]
data source: Reactome
xref: UnificationXref183
xref: UnificationXref182
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113581
display name: ADP

Oxalacetic acid
type: SmallMolecule
entity reference: CHEBI:30744
data source: Reactome
name: Oxosuccinic acid
name: 2-oxobutanedioic acid
name: Oxaloacetic acid
name: Oxaloacetate
xref: UnificationXref180
xref: UnificationXref181
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113587
display name: OA

UDP-D-galactopyranose
type: SmallMolecule
entity reference: UDP-D-galactose [ChEBI:18307]
data source: Reactome
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref221
xref: UnificationXref222
cellular location: cytosol
comment: Reactome DB_ID: 29452
display name: UDP-Gal

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
name: Inorganic Phosphate
xref: UnificationXref207
xref: UnificationXref208
cellular location: cytosol
comment: Reactome DB_ID: 29372
display name: Pi

Acetyl coenzyme A
type: SmallMolecule
entity reference: Acetyl coenzyme A
data source: Reactome
name: Acetyl-CoA
xref: UnificationXref199
xref: UnificationXref200
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113559
display name: Ac-CoA

Mn(III)
type: SmallMolecule
entity reference: CHEBI:18291
data source: Reactome
name: Mn(II)
name: Manganese
xref: UnificationXref194
xref: UnificationXref193
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113527
display name: Mn2+

Pyruvate
type: SmallMolecule
entity reference: Pyruvate
data source: Reactome
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref177
xref: UnificationXref178
cellular location: mitochondrial matrix
comment: Reactome DB_ID: 113557
display name: PYR

Nitric oxide stimulates guanylate cyclase
type: Pathway
data source: Reactome
pathway component: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
evidence: Evidence2
xref: UnificationXref30
xref: UnificationXref31
pathway order: PathwayStep1
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/18006660
type: PublicationXref
id: 18006660
author: Foster, LJ
author: Rogers, LD
db: Pubmed
title: The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum
source: Proc Natl Acad Sci U S A 104:18520-5
year: 2007

http://identifiers.org/pubmed/16051738
type: PublicationXref
id: 16051738
author: van Solinge, WW
author: van Wijk, R
db: Pubmed
title: The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis
source: Blood 106:4034-42
year: 2005

sperm flagellum
type: CellularLocationVocabulary
xref: UnificationXref2949

http://identifiers.org/pubmed/7821823
type: PublicationXref
id: 7821823
author: MacDonald, MJ
author: Simonson, GD
author: Lehn, DA
author: Brown, LJ
author: Moran, SM
db: Pubmed
title: The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA
source: Gene 150:417-8
year: 1994

Synthesis of 5-eicosatetraenoic acids
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction42
evidence: Evidence80
xref: RelationshipXref95
xref: UnificationXref615
xref: UnificationXref614
pathway order: PathwayStep76
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/11175906
type: PublicationXref
id: 11175906
author: Burden, A
author: Wu, CK
author: Wang, BC
author: Dailey, HA
author: Rose, JP
author: Sellers, VM
db: Pubmed
title: The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.
source: Nat Struct Biol 8:156-60
year: 2001

http://identifiers.org/pubmed/10745006
type: PublicationXref
id: 10745006
author: Chuang, JL
author: Turley, S
author: Chuang, DT
author: Aevarsson, A
author: Wynn, RM
author: Hol, WG
db: Pubmed
title: Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
source: Structure Fold Des 8:277-91
year: 2000

http://identifiers.org/pubmed/9520412
type: PublicationXref
id: 9520412
author: Nevins, JR
author: DeGregori, J
author: Leone, G
author: Shohet, R
author: Yan, Z
author: Williams, RS
author: Stillman, B
db: Pubmed
title: Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
source: Proc Natl Acad Sci U S A 95:3603-8
year: 1998

http://identifiers.org/pubmed/15845646
type: PublicationXref
id: 15845646
author: Desjardins, M
author: Bergeron, JJ
author: Gagnon, E
db: Pubmed
title: ER-mediated phagocytosis: myth or reality?
source: J Leukoc Biol 77:843-5
year: 2005

UnificationXref2347
type: UnificationXref
id: P67572
db: UniProt

UnificationXref2346
type: UnificationXref
id: REACT_16009
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16009.1

UnificationXref2349
type: UnificationXref
id: 4230732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230732

UnificationXref2348
type: UnificationXref
id: 4230730
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230730

UnificationXref2341
type: UnificationXref
id: CHEBI:29172
db: ChEBI

UnificationXref2340
type: UnificationXref
id: REACT_15752
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15752.2

UnificationXref2343
type: UnificationXref
id: REACT_15719
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15719.1

UnificationXref2342
type: UnificationXref
id: 379699
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379699

UnificationXref2345
type: UnificationXref
id: 379718
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379718

UnificationXref2344
type: UnificationXref
id: CHEBI:29265
db: ChEBI

UniProt:P99064
type: ProteinReference
xref: UnificationXref949
organism: BioSource1

UniProt:P99063
type: ProteinReference
xref: UnificationXref1661
organism: BioSource1

UniProt:P99068
type: ProteinReference
xref: UnificationXref1337
organism: BioSource1

http://identifiers.org/pubmed/11914032
type: PublicationXref
id: 11914032
author: Kim, HK
author: Cederbaum, SD
author: Tsoa, RW
author: Grody, WW
author: Iyer, RK
db: Pubmed
title: Cloning and characterization of human agmatinase
source: Mol Genet Metab 75:209-18
year: 2002

UnificationXref2359
type: UnificationXref
id: P67015
db: UniProt

UnificationXref2358
type: UnificationXref
id: REACT_16074
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16074.1

UnificationXref2357
type: UnificationXref
id: 379698
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379698

Aquaporin-mediated transport
type: Pathway
data source: Reactome
pathway component: Passive Transport by Aquaporins
pathway component: REACT 156920.3
pathway component: REACT 157632.3
evidence: Evidence408
xref: UnificationXref2914
xref: UnificationXref2913
xref: RelationshipXref472
pathway order: PathwayStep398
pathway order: PathwayStep395
pathway order: PathwayStep393
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2352
type: UnificationXref
id: 379715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379715

UnificationXref2351
type: UnificationXref
id: CHEBI:29186
db: ChEBI

UnificationXref2350
type: UnificationXref
id: REACT_115176
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115176.8

UnificationXref2356
type: UnificationXref
id: CHEBI:29158
db: ChEBI

UnificationXref2355
type: UnificationXref
id: REACT_5003
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5003.2

UnificationXref2354
type: UnificationXref
id: 113553
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113553

UnificationXref2353
type: UnificationXref
id: REACT_15813
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15813.1

http://identifiers.org/pubmed/12399160
type: PublicationXref
id: 12399160
author: Walsh, JS
author: Thurmond, LM
author: Reese, MJ
db: Pubmed
title: The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes
source: Chem Biol Interact 142:135-54
year: 2002

UnificationXref2329
type: UnificationXref
id: 379784
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379784

UnificationXref2328
type: UnificationXref
id: CHEBI:29156
db: ChEBI

UnificationXref2325
type: UnificationXref
id: CHEBI:29176
db: ChEBI

UnificationXref2324
type: UnificationXref
id: REACT_113444
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113444.8

UnificationXref2327
type: UnificationXref
id: REACT_15638
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15638.1

UnificationXref2326
type: UnificationXref
id: 379766
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379766

UnificationXref2321
type: UnificationXref
id: 4231344
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231344

UnificationXref2320
type: UnificationXref
id: REACT_114027
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114027.8

UnificationXref2323
type: UnificationXref
id: 4231345
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231345

UnificationXref2322
type: UnificationXref
id: REACT_112265
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112265.8

UniProt:P99088
type: ProteinReference
xref: UnificationXref139
organism: BioSource1

UniProt:P99085
type: ProteinReference
xref: UnificationXref1050
organism: BioSource1

UniProt:P99084
type: ProteinReference
xref: UnificationXref823
organism: BioSource1

UniProt:Q7A5B8
type: ProteinReference
xref: UnificationXref1178
organism: BioSource1

http://identifiers.org/pubmed/16584116
type: PublicationXref
id: 16584116
author: Guengerich, FP
db: Pubmed
title: Cytochrome P450s and other enzymes in drug metabolism and toxicity
source: AAPS J 8:E101-11
year: 2006

UnificationXref2339
type: UnificationXref
id: 379703
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379703

UnificationXref2338
type: UnificationXref
id: CHEBI:17196
db: ChEBI

UnificationXref2337
type: UnificationXref
id: REACT_104381
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_104381.9

UnificationXref2336
type: UnificationXref
id: 4231360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231360

UnificationXref2335
type: UnificationXref
id: REACT_94097
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_94097.9

UnificationXref2334
type: UnificationXref
id: 4230686
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230686

UnificationXref2333
type: UnificationXref
id: 4230684
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230684

UnificationXref2332
type: UnificationXref
id: 4230683
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230683

UnificationXref2331
type: UnificationXref
id: P99129
db: UniProt

UnificationXref2330
type: UnificationXref
id: REACT_18164
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_18164.1

UniProt:P99076
type: ProteinReference
xref: UnificationXref1747
organism: BioSource1

UniProt:P99073
type: ProteinReference
xref: UnificationXref1793
organism: BioSource1

http://identifiers.org/pubmed/11096114
type: PublicationXref
id: 11096114
author: Fleming, KG
author: Beardsley, GP
author: Bulock, KG
author: Vergis, JM
db: Pubmed
title: Human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity
source: J Biol Chem 276:7727-7733
year: 2001

http://identifiers.org/pubmed/11279194
type: PublicationXref
id: 11279194
author: Orlowski, J
author: Numata, M
db: Pubmed
title: Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network
source: J Biol Chem 276:17387-94
year: 2001

UniProt:P99079
type: ProteinReference
xref: UnificationXref755
organism: BioSource1

UniProt:Q7A5C9
type: ProteinReference
xref: UnificationXref1253
organism: BioSource1

UniProt:P99078
type: ProteinReference
xref: UnificationXref53
organism: BioSource1

http://identifiers.org/pubmed/11008000
type: PublicationXref
id: 11008000
author: Karlsson, A
author: Johansson, M
author: Van Rompay, AR
db: Pubmed
title: Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases
source: Pharmacol Ther 87:189-198
year: 2000

UnificationXref2300
type: UnificationXref
id: REACT_112750
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112750.8

UnificationXref2301
type: UnificationXref
id: 264618
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=264618

UnificationXref2302
type: UnificationXref
id: REACT_15646
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15646.2

UnificationXref2303
type: UnificationXref
id: Q7A4Q7
db: UniProt

UnificationXref2304
type: UnificationXref
id: 4230640
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230640

UnificationXref2305
type: UnificationXref
id: 4230642
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230642

UnificationXref2306
type: UnificationXref
id: REACT_115008
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_115008.8

UnificationXref2307
type: UnificationXref
id: 4231351
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231351

UnificationXref2308
type: UnificationXref
id: REACT_112807
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_112807.8

UnificationXref2309
type: UnificationXref
id: 4231343
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231343

Purine catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction81
pathway component: BiochemicalReaction82
pathway component: BiochemicalReaction83
evidence: Evidence143
xref: UnificationXref1112
xref: UnificationXref1111
xref: RelationshipXref169
pathway order: PathwayStep138
pathway order: PathwayStep139
pathway order: PathwayStep137
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Oxoglutaric acid
type: SmallMoleculeReference
name: 2-Oxoglutarate [ChEBI:30915]
name: 2-Oxoglutarate
name: alpha-Ketoglutaric acid
name: 2-Ketoglutaric acid
xref: UnificationXref817

UnificationXref2311
type: UnificationXref
id: 4231356
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231356

UnificationXref2312
type: UnificationXref
id: REACT_158424
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_158424.3

UnificationXref2310
type: UnificationXref
id: REACT_113329
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_113329.8

UnificationXref2315
type: UnificationXref
id: 4230635
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230635

UnificationXref2316
type: UnificationXref
id: 4230637
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230637

http://identifiers.org/pubmed/1999334
type: PublicationXref
id: 1999334
author: Ogata, M
db: Pubmed
title: Acatalasemia.
source: Hum Genet 86:331-40
year: 1991

UnificationXref2313
type: UnificationXref
id: 4230633
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230633

UnificationXref2314
type: UnificationXref
id: 4230634
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230634

UnificationXref2319
type: UnificationXref
id: 4231347
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231347

UnificationXref2317
type: UnificationXref
id: 4231346
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231346

http://identifiers.org/pubmed/3944130
type: PublicationXref
id: 3944130
author: Forte-McRobbie, CM
author: Pietruszko, R
db: Pubmed
title: Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase.
source: J Biol Chem 261:2154-63
year: 1986

UnificationXref2318
type: UnificationXref
id: REACT_114748
db: Reactome
id version: 8
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_114748.8

http://identifiers.org/pubmed/9701566
type: PublicationXref
id: 9701566
author: Lehtonen, E
author: Ehnholm, C
author: Galli, T
author: Riento, K
author: Jansson, S
author: Olkkonen, VM
db: Pubmed
title: Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells
source: J Cell Sci 111:2681-8
year: 1998

E2F mediated regulation of DNA replication
type: Pathway
data source: Reactome
pathway component: TemplateReaction4
evidence: Evidence442
xref: UnificationXref3036
xref: UnificationXref3035
pathway order: PathwayStep426
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

3-Phosphonooxypyruvic acid
type: SmallMoleculeReference
name: 3-Phosphohydroxypyruvic acid
name: 3-Phosphonooxypyruvate
name: 3-Phosphonooxypyruvate [ChEBI:1661]
name: 3-Phosphohydroxypyruvate
xref: UnificationXref1620

http://identifiers.org/pubmed/16098809
type: PublicationXref
id: 16098809
author: Simmonds, HA
author: Zameitat, E
author: Fairbanks, LD
author: Marinaki, AM
author: Loffler, M
db: Pubmed
title: Pyrimidine pathways in health and disease
source: Trends Mol Med 11:430-7
year: 2005

http://identifiers.org/pubmed/11278832
type: PublicationXref
id: 11278832
author: Lin, Shengrong
author: Yuan, Youzhong
author: Wang, Z
author: Mao, Y
author: McLennan, Alexander G
author: Wu, Chaoqun
author: Jin, Hua
author: Liu, Weiping
author: Gu, S
author: Xie, Y
author: Tang, Rong
author: Ying, K
db: Pubmed
title: Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
source: J. Biol. Chem. 276:18695-701
year: 2001

http://identifiers.org/pubmed/7574501
type: PublicationXref
id: 7574501
author: Kurland, IJ
author: Claus, TH
author: Pilkis, SJ
author: Lange, AJ
db: Pubmed
title: 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.
source: Annu Rev Biochem 64:799-835
year: 1995

Developmental Biology
type: Pathway
data source: Reactome
pathway component: REACT 153422.3
evidence: Evidence9
xref: UnificationXref45
xref: UnificationXref46
pathway order: PathwayStep6
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

GPHN:Mg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry175
component stoichiometry: Stoichiometry176
component: Mg++
component: Protein120
xref: UnificationXref1593
cellular location: plasma membrane
comment: Reactome DB_ID: 4231045

http://identifiers.org/pubmed/12838422
type: PublicationXref
id: 12838422
author: Young, JD
author: Yao, SY
author: Baldwin, SA
author: Beal, PR
author: King, AE
author: Cass, CE
db: Pubmed
title: The equilibrative nucleoside transporter family, SLC29
source: Pflugers Archpreprint
year: 2003

3xGPHN:3xMg2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry177
component: GPHN:Mg2+ (name copied from entity in Homo sapiens)
xref: UnificationXref1594
cellular location: plasma membrane
comment: Reactome DB_ID: 4231046

PHGHD tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry179
component: Protein124
xref: UnificationXref1625
cellular location: intracellular
comment: Reactome DB_ID: 4231081

OAT hexamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry178
component: Protein121
xref: UnificationXref1615
cellular location: intracellular
comment: Reactome DB_ID: 4229882

UnificationXref237
type: UnificationXref
id: 31467
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31467

ACMSD dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry194
component: Protein141
xref: UnificationXref1762
cellular location: intracellular
comment: Reactome DB_ID: 4229994

UnificationXref236
type: UnificationXref
id: CHEBI:16938
db: ChEBI

OTC trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry197
component: Protein145
xref: UnificationXref1798
cellular location: intracellular
comment: Reactome DB_ID: 4229852

UDP-D-galactose [ChEBI:18307]
type: SmallMoleculeReference
name: UDP-D-galactopyranose
name: UDPgalactose
name: UDP-D-galactose
xref: UnificationXref220

UnificationXref239
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ASS1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry198
component: Protein148
xref: UnificationXref1806
cellular location: intracellular
comment: Reactome DB_ID: 4229870

UnificationXref238
type: UnificationXref
id: REACT_4982
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4982.1

ASL tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry199
component: Protein149
xref: UnificationXref1811
cellular location: intracellular
comment: Reactome DB_ID: 4229864

ALDH4A1 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry193
component: Protein140
xref: UnificationXref1749
cellular location: intracellular
comment: Reactome DB_ID: 4229889

TAT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry192
component: Protein139
xref: UnificationXref1740
cellular location: intracellular
comment: Reactome DB_ID: 4229988

GCDH tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry191
component stoichiometry: Stoichiometry190
component: Protein138
component: Flavin adenine dinucleotide
xref: UnificationXref1725
cellular location: intracellular
comment: Reactome DB_ID: 4229981

UnificationXref230
type: UnificationXref
id: 4229754
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229754

UnificationXref231
type: UnificationXref
id: 4229755
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229755

UnificationXref232
type: UnificationXref
id: 4229757
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229757

branched-chain alpha-ketoacid dehydrogenase E1 complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry183
component stoichiometry: Stoichiometry182
component stoichiometry: Stoichiometry184
component: Protein128
component: Thiamin diphosphate
component: Protein131
xref: UnificationXref1669
cellular location: intracellular
comment: Reactome DB_ID: 4229912

UnificationXref233
type: UnificationXref
id: REACT_78749
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_78749.9

branched-chain alpha-ketoacid dehydrogenase complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry185
component stoichiometry: Stoichiometry180
component stoichiometry: Stoichiometry181
component: Protein125
component: branched-chain alpha-ketoacid dehydrogenase E1 complex (name copied from entity in Homo sapiens)
component: alpha-keto acid dehydrogenase E3 homodimer (name copied from entity in Homo sapiens)
xref: UnificationXref1670
cellular location: intracellular
comment: Reactome DB_ID: 4229927

UnificationXref234
type: UnificationXref
id: 4231256
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231256

AADAT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry189
component: Protein137
xref: UnificationXref1710
cellular location: intracellular
comment: Reactome DB_ID: 4229950

UnificationXref235
type: UnificationXref
id: REACT_107846
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_107846.9

urocanate hydratase (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry187
component stoichiometry: Stoichiometry186
component: DPN
component: Protein135
xref: UnificationXref1690
cellular location: intracellular
comment: Reactome DB_ID: 4229938

http://identifiers.org/pubmed/12202949
type: PublicationXref
id: 12202949
author: Heath-Monnig, E
author: Kamath, SG
author: Smith, CH
author: Furesz, TC
db: Pubmed
title: Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes
source: J Membr Biol 189:27-33
year: 2002

UnificationXref228
type: UnificationXref
id: REACT_5381
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5381.1

MAT I homotetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry214
component: MAT I/III (Mg, K cofactors) (name copied from entity in Homo sapiens)
xref: UnificationXref1931
cellular location: intracellular
comment: Reactome DB_ID: 4230434

1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole
type: SmallMoleculeReference
name: 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide
name: SAICAR
name: 5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
name: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole [ChEBI:18319]
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
name: 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
xref: UnificationXref957

UnificationXref227
type: UnificationXref
id: 29360
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360

MAT I/III (Mg, K cofactors) (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry212
component stoichiometry: Stoichiometry211
component stoichiometry: Stoichiometry213
component: Note: the coordinates are copied over from Homo sapiens.
component: Potassium
component: Mg++
xref: UnificationXref1930
cellular location: intracellular
comment: Reactome DB_ID: 4230433

UnificationXref226
type: UnificationXref
id: CHEBI:15846
db: ChEBI

AGXT dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry210
component: Q7A543
xref: UnificationXref1912
cellular location: intracellular
comment: Reactome DB_ID: 4230765

UnificationXref225
type: UnificationXref
id: REACT_3006
db: Reactome
id version: 3
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3006.3

MAT multimers
type: Complex
data source: Reactome
member physical entity: MAT III homodimer (name copied from entity in Homo sapiens)
member physical entity: MAT I homotetramer (name copied from entity in Homo sapiens)
xref: UnificationXref1933
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230436

creatine kinase, sarcomeric, octamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry206
component: Protein154
xref: UnificationXref1859
cellular location: intracellular
comment: Reactome DB_ID: 4230579

creatine kinase, ubiquitous, octamer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry207
component: Protein155
xref: UnificationXref1861
cellular location: intracellular
comment: Reactome DB_ID: 4230581

http://identifiers.org/pubmed/17612490
type: PublicationXref
id: 17612490
author: Lennon, CJ
author: Dynlacht, BD
author: Lents, NH
author: Kluger, Y
author: Tsikitis, M
author: Arias, C
author: Acosta-Alvear, D
author: Blais, A
author: Zhou, Y
db: Pubmed
title: XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
source: Mol Cell 27:53-66
year: 2007

UnificationXref229
type: UnificationXref
id: Q7A859
db: UniProt

UnificationXref220
type: UnificationXref
id: CHEBI:18307
db: ChEBI

creatine kinase octamers
type: Complex
data source: Reactome
member physical entity: creatine kinase, sarcomeric, octamer (name copied from entity in Homo sapiens)
member physical entity: creatine kinase, ubiquitous, octamer (name copied from entity in Homo sapiens)
xref: UnificationXref1862
cellular location: intracellular
display name: CK octamers
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230582

UnificationXref223
type: UnificationXref
id: CHEBI:18066
db: ChEBI

creatine kinase BB dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry205
component: Protein153
xref: UnificationXref1855
cellular location: intracellular
comment: Reactome DB_ID: 4230575

UnificationXref224
type: UnificationXref
id: 29410
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29410

ALDH9A1 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry204
component: Protein152
xref: UnificationXref1842
cellular location: intracellular
comment: Reactome DB_ID: 4230000

UnificationXref221
type: UnificationXref
id: 29452
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29452

ARG2 trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry203
component stoichiometry: Stoichiometry202
component: Mn(III)
component: Protein151
xref: UnificationXref1829
cellular location: intracellular
comment: Reactome DB_ID: 4230978

UnificationXref222
type: UnificationXref
id: REACT_5012
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5012.2

ARG1 trimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry200
component stoichiometry: Stoichiometry201
component: Protein150
component: Mn(III)
xref: UnificationXref1821
cellular location: intracellular
comment: Reactome DB_ID: 4229858

UniProt:Q7A5N4
type: ProteinReference
xref: UnificationXref827
organism: BioSource1

8xALAD:Pb2+:Zn2+ (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry234
component stoichiometry: Stoichiometry232
component stoichiometry: Stoichiometry233
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule371
component: Zn(II)
xref: UnificationXref1979
cellular location: intracellular
comment: Reactome DB_ID: 4230485

HMBS:DIPY (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry240
component stoichiometry: Stoichiometry239
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule375
xref: UnificationXref1998
cellular location: intracellular
comment: Reactome DB_ID: 4230456

2xUROD (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry242
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2009
cellular location: intracellular
comment: Reactome DB_ID: 4230468

UnificationXref259
type: UnificationXref
id: 4230006
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230006

2xPPO:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry246
component stoichiometry: Stoichiometry247
component: SmallMolecule384
component: Protoporphyrinogen oxidase
xref: UnificationXref2035
cellular location: intracellular
comment: Reactome DB_ID: 4230462

http://identifiers.org/pubmed/16213220
type: PublicationXref
id: 16213220
author: van der Wel, N
author: Peters, PJ
author: Houben, D
author: Shaw, J
author: Grinstein, S
author: de Chastellier, C
author: Paroutis, P
author: Harrison, RE
author: Moore, HP
author: Pypaert, M
author: Jiang, A
author: Trombetta, S
author: Chow, A
author: Terebiznik, M
author: Touret, N
author: Yip, C
author: Mellman, I
db: Pubmed
title: Quantitative and dynamic assessment of the contribution of the ER to phagosome formation
source: Cell 123:157-70
year: 2005

UnificationXref258
type: UnificationXref
id: 4230005
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230005

2x(FECH:2Fe-2S cluster) (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry250
component stoichiometry: Stoichiometry249
component: 2Iron-2Sulfur Cluster
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2047
cellular location: intracellular
comment: Reactome DB_ID: 4230481

alcohol dehydrogenase complex
type: Complex
data source: Reactome
member physical entity: ADH1A dimer (name copied from entity in Homo sapiens)
member physical entity: alcohol dehydrogenase 6 (class V) complex (name copied from entity in Homo sapiens)
member physical entity: alcohol dehydrogenase 7 (class IV), mu or sigma dimer (name copied from entity in Homo sapiens)
member physical entity: alcohol dehydrogenase 4 (class II), pi dimer (name copied from entity in Homo sapiens)
xref: UnificationXref2079
cellular location: intracellular
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230057

http://identifiers.org/pubmed/14624363
type: PublicationXref
id: 14624363
author: Bruford, EA
author: Hediger, MA
author: Rolfs, A
author: Romero, MF
author: Takanaga, H
author: Peng, JB
db: Pubmed
title: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
source: Pflugers Arch 447:465-8
year: 2004

ADH1A dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry252
component stoichiometry: Stoichiometry251
component: Q7A7V4
component: Zn(II)
xref: UnificationXref2072
cellular location: intracellular
comment: Reactome DB_ID: 4230050

UnificationXref254
type: UnificationXref
id: CHEBI:17363
db: ChEBI

BHMT tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry219
component stoichiometry: Stoichiometry218
component: Note: the coordinates are copied over from Homo sapiens.
component: Zn(II)
xref: UnificationXref1947
cellular location: intracellular
comment: Reactome DB_ID: 4231136

N-Formimidoyl-L-glutamate
type: SmallMoleculeReference
name: N-Formimino-L-glutamate [ChEBI:18327]
name: N-Formimino-L-glutamate
xref: UnificationXref1693

UnificationXref255
type: UnificationXref
id: 29732
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29732

MAT III homodimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry215
component stoichiometry: Stoichiometry217
component stoichiometry: Stoichiometry216
component: Note: the coordinates are copied over from Homo sapiens.
component: Potassium
component: Mg++
xref: UnificationXref1932
cellular location: intracellular
comment: Reactome DB_ID: 4230435

UnificationXref256
type: UnificationXref
id: REACT_3483
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3483.2

8x(ALAD:Zn2+) (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry230
component stoichiometry: Stoichiometry229
component: Note: the coordinates are copied over from Homo sapiens.
component: Zn(II)
xref: UnificationXref1978
cellular location: intracellular
comment: Reactome DB_ID: 4230474

UnificationXref257
type: UnificationXref
id: P63334
db: UniProt

SQR:FAD (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry226
component stoichiometry: Stoichiometry227
component: Note: the coordinates are copied over from Homo sapiens.
component: SmallMolecule370
xref: UnificationXref1962
cellular location: intracellular
comment: Reactome DB_ID: 4231142

UnificationXref250
type: UnificationXref
id: 29996
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29996

UnificationXref251
type: UnificationXref
id: REACT_2623
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2623.2

UnificationXref252
type: UnificationXref
id: 113528
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113528

UniProt:Q7A5K6
type: ProteinReference
xref: UnificationXref3095
organism: BioSource1

UnificationXref253
type: UnificationXref
id: REACT_2373
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2373.1

DARS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry269
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2361
cellular location: intracellular
comment: Reactome DB_ID: 4230736

GARS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry270
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2381
cellular location: intracellular
comment: Reactome DB_ID: 4230752

6xUGDH (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry262
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2105
cellular location: intracellular
comment: Reactome DB_ID: 4230427

GARS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry268
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2333
cellular location: intracellular
comment: Reactome DB_ID: 4230684

YARS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry273
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2498
cellular location: intracellular
comment: Reactome DB_ID: 4230695

Aquaporins that transport water across the plasma membrane.
type: Complex
data source: Reactome
member physical entity: AQP9 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP10 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP7 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP3 tetramer (name copied from entity in Homo sapiens)
name: AQP0 (MIP), AQP1, p-AQP2, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, AQP11
name: Aquaporin-0, Aquaporin-1, Phospho-Aquaporin-2, Aquaporin-3, Aquaporin-4, Aquaporin-5, Aquaporin-7, Aquaporin-8, Aquaporin-9, Aquaporin-10, Aquaporin-11
xref: UnificationXref2887
cellular location: plasma membrane
display name: AQP0/1/2/3/4/5/7/8/9/10/11
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4230995

UnificationXref249
type: UnificationXref
id: CHEBI:16863
db: ChEBI

KARS dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry271
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2421
cellular location: intracellular
comment: Reactome DB_ID: 4230742

UnificationXref248
type: UnificationXref
id: REACT_28663
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_28663.10

http://identifiers.org/pubmed/762062
type: PublicationXref
id: 762062
author: Itakura, M
author: Holmes, EW
db: Pubmed
title: Human amidophosphoribosyltransferase. An oxygen-sensitive iron-sulfur protein
source: J Biol Chem 254:333-338
year: 1979

SARS2 dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry272
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2472
cellular location: intracellular
comment: Reactome DB_ID: 4230748

UnificationXref247
type: UnificationXref
id: 4229765
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229765

Pantothenic acid
type: SmallMoleculeReference
name: Pantothenate
name: Pantothenate [ChEBI:7916]
xref: UnificationXref1417

Glucocorticoid biosynthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction34
evidence: Evidence62
xref: RelationshipXref69
xref: UnificationXref478
xref: UnificationXref477
pathway order: PathwayStep58
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref245
type: UnificationXref
id: 4229762
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229762

UnificationXref246
type: UnificationXref
id: 4229763
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229763

alcohol dehydrogenase 7 (class IV), mu or sigma dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry257
component stoichiometry: Stoichiometry258
component: Q7A7V4
component: Zn(II)
xref: UnificationXref2078
cellular location: intracellular
comment: Reactome DB_ID: 4230056

UnificationXref243
type: UnificationXref
id: 4229760
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229760

alcohol dehydrogenase 6 (class V) complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry256
component stoichiometry: Stoichiometry255
component: Q7A7V4
component: Zn(II)
xref: UnificationXref2076
cellular location: intracellular
comment: Reactome DB_ID: 4230054

UnificationXref244
type: UnificationXref
id: 4229761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4229761

alcohol dehydrogenase 4 (class II), pi dimer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry254
component stoichiometry: Stoichiometry253
component: Q7A7V4
component: Zn(II)
xref: UnificationXref2074
cellular location: intracellular
comment: Reactome DB_ID: 4230052

UnificationXref241
type: UnificationXref
id: REACT_4941
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4941.2

UnificationXref242
type: UnificationXref
id: Q7A5G7
db: UniProt

UnificationXref240
type: UnificationXref
id: 70106
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106

Metabolism of vitamins and cofactors
type: Pathway
data source: Reactome
pathway component: Metabolism of water-soluble vitamins and cofactors
evidence: Evidence205
xref: RelationshipXref249
xref: UnificationXref1602
xref: UnificationXref1601
pathway order: PathwayStep201
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

MPG glycosylase:3-methyladenine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry303
component stoichiometry: Stoichiometry304
component: Double-strand DNA containing a 3-methyladenine
component: 3-alkyladenine DNA glycosylase
xref: UnificationXref3050
cellular location: intracellular
comment: Reactome DB_ID: 4230347

http://identifiers.org/pubmed/3036115
type: PublicationXref
id: 3036115
author: Low, MG
author: Ruedi, JM
author: Thompson, LF
db: Pubmed
title: Purification of 5'-nucleotidase from human placenta after release from plasma membranes by phosphatidylinositol-specific phospholipase C
source: Biochem Biophys Res Commun 145:118-125
year: 1987

TAP (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry301
component stoichiometry: Stoichiometry302
component: Q7A708
xref: UnificationXref3013
cellular location: intracellular
comment: Reactome DB_ID: 4231090

MPG glycosylase:hypoxanthine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry307
component stoichiometry: Stoichiometry308
component: Double-strand DNA containing a hypoxanthine
component: 3-alkyladenine DNA glycosylase
xref: UnificationXref3058
cellular location: intracellular
comment: Reactome DB_ID: 4230353

MPG glycosylase:ethenoadenine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry306
component stoichiometry: Stoichiometry305
component: Double-strand DNA containing an ethenoadenine
component: 3-alkyladenine DNA glycosylase
xref: UnificationXref3054
cellular location: intracellular
comment: Reactome DB_ID: 4230350

Aquaporin-9, Aquaporin-10
type: Complex
data source: Reactome
member physical entity: AQP9 tetramer (name copied from entity in Homo sapiens)
member physical entity: AQP10 tetramer (name copied from entity in Homo sapiens)
name: Aquaporins that transport urea
name: AQP9, AQP10
xref: UnificationXref2896
cellular location: plasma membrane
display name: AQP9/10
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 4231002

AQP10 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry295
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2886
cellular location: plasma membrane
comment: Reactome DB_ID: 4230994

2xUAP1 (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry296
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2982
cellular location: intracellular
comment: Reactome DB_ID: 4230950

2xUAP1-2 (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry297
component: 2xUAP1 (name copied from entity in Homo sapiens)
xref: UnificationXref2983
cellular location: intracellular
comment: Reactome DB_ID: 4230951

AQP9 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry294
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2884
cellular location: plasma membrane
comment: Reactome DB_ID: 4230880

Branched-chain amino acid catabolism
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction133
evidence: Evidence212
xref: UnificationXref1673
xref: UnificationXref1674
xref: RelationshipXref258
pathway order: PathwayStep208
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref271
type: UnificationXref
id: REACT_30648
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_30648.10

UnificationXref270
type: UnificationXref
id: 4230571
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230571

http://identifiers.org/pubmed/11032836
type: PublicationXref
id: 11032836
author: Kervinen, J
author: Dunbrack RL, Jr
author: Jaffe, EK
author: Martins, J
author: Li, J
db: Pubmed
title: The molecular mechanism of lead inhibition of human porphobilinogen synthase
source: J Biol Chem 276:1531-7
year: 2001

UnificationXref273
type: UnificationXref
id: 73578
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73578

UnificationXref272
type: UnificationXref
id: CHEBI:17797
db: ChEBI

UnificationXref275
type: UnificationXref
id: P66695
db: UniProt

UnificationXref274
type: UnificationXref
id: REACT_4214
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4214.2

5-phosphoribosylglycinamide [ChEBI:18349]
type: SmallMoleculeReference
name: Glycinamide ribonucleotide
name: GAR
name: 5-phosphoribosylglycinamide
name: N1-(5-Phospho-D-ribosyl)glycinamide
xref: UnificationXref920

AQP3 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry292
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2880
cellular location: plasma membrane
comment: Reactome DB_ID: 4230944

UnificationXref277
type: UnificationXref
id: 4230019
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230019

AQP7 tetramer (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry293
component: Note: the coordinates are copied over from Homo sapiens.
xref: UnificationXref2882
cellular location: plasma membrane
comment: Reactome DB_ID: 4230884

UnificationXref276
type: UnificationXref
id: 4230017
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230017

UnificationXref279
type: UnificationXref
id: 4230446
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230446

http://identifiers.org/pubmed/11032837
type: PublicationXref
id: 11032837
author: Hyde, RJ
author: Chen, XZ
author: Loewen, SK
author: Young, JD
author: Yao, SY
author: Mowles, DA
author: Ritzel, MW
author: Ng, AM
author: Karpinski, E
author: Carpenter, P
author: Cass, CE
author: Ritzel, RG
author: Smith, KM
author: Graham, K
author: Baldwin, SA
db: Pubmed
title: Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
source: J Biol Chem 276:2914-2927
year: 2001

UnificationXref278
type: UnificationXref
id: REACT_102385
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_102385.9

UnificationXref269
type: UnificationXref
id: REACT_93209
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_93209.9

DNA containing a hNTH1-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry323
component stoichiometry: Stoichiometry324
component: Note: the coordinates are copied over from Homo sapiens.
component: DNA containing an apurinic/apyrimidinic (AP) site
xref: UnificationXref3115
cellular location: intracellular
comment: Reactome DB_ID: 4230330

hNTH1 glycosylase:thymine glycol complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry322
component stoichiometry: Stoichiometry321
component: Note: the coordinates are copied over from Homo sapiens.
component: Double-strand DNA containing a thymine glycol
xref: UnificationXref3110
cellular location: intracellular
comment: Reactome DB_ID: 4230320

hNTH1 glycosylase: foramidopyrimidine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry320
component stoichiometry: Stoichiometry319
component: Note: the coordinates are copied over from Homo sapiens.
component: Double-strand DNA containing a formamidopyrimidine
xref: UnificationXref3106
cellular location: intracellular
comment: Reactome DB_ID: 4230326

hNTH1 glycosylase:dihydrouracil complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry317
component stoichiometry: Stoichiometry318
component: Note: the coordinates are copied over from Homo sapiens.
component: Double-strand DNA containing a dihydrouracil
xref: UnificationXref3102
cellular location: intracellular
comment: Reactome DB_ID: 4230323

hNTH1 glycosylase:cytosine glycol complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry316
component stoichiometry: Stoichiometry315
component: Note: the coordinates are copied over from Homo sapiens.
component: Double-strand DNA containing a cytosine glycol
xref: UnificationXref3098
cellular location: intracellular
comment: Reactome DB_ID: 4230317

DNA containing an MPG-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry314
component stoichiometry: Stoichiometry313
component: DNA containing an apurinic/apyrimidinic (AP) site
component: 3-alkyladenine DNA glycosylase
xref: UnificationXref3076
cellular location: intracellular
comment: Reactome DB_ID: 4230358

DNA containing an MYH-bound apurinic/apyrimidinic site (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry312
component stoichiometry: Stoichiometry311
component: Note: the coordinates are copied over from Homo sapiens.
component: DNA containing an apurinic/apyrimidinic (AP) site
xref: UnificationXref3073
cellular location: intracellular
comment: Reactome DB_ID: 4230355

UnificationXref260
type: UnificationXref
id: 4230008
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230008

UnificationXref264
type: UnificationXref
id: REACT_3046
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3046.2

UnificationXref263
type: UnificationXref
id: 29790
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29790

UnificationXref262
type: UnificationXref
id: CHEBI:16332
db: ChEBI

UnificationXref261
type: UnificationXref
id: REACT_103331
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_103331.9

UnificationXref268
type: UnificationXref
id: 4230014
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230014

UnificationXref267
type: UnificationXref
id: 4230012
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230012

UniProt:Q7A5J3
type: ProteinReference
xref: UnificationXref685
organism: BioSource1

MYH glycosylase:adenine complex (name copied from entity in Homo sapiens)
type: Complex
data source: Reactome
component stoichiometry: Stoichiometry310
component stoichiometry: Stoichiometry309
component: Note: the coordinates are copied over from Homo sapiens.
component: Double-strand DNA containing an adenine opposite to an 8-oxo guanine
xref: UnificationXref3064
cellular location: intracellular
comment: Reactome DB_ID: 4230341

UnificationXref266
type: UnificationXref
id: 4230011
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230011

UnificationXref265
type: UnificationXref
id: Q7A5Z7
db: UniProt

UniProt:Q7A5F8
type: ProteinReference
xref: UnificationXref1659
organism: BioSource1

UniProt:Q7A5F7
type: ProteinReference
xref: UnificationXref1666
organism: BioSource1

UniProt:Q7A5F9
type: ProteinReference
xref: UnificationXref1656
organism: BioSource1

UnificationXref291
type: UnificationXref
id: REACT_2628
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_2628.2

UnificationXref290
type: UnificationXref
id: 73566
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=73566

UnificationXref293
type: UnificationXref
id: 4230111
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230111

UnificationXref292
type: UnificationXref
id: P65237
db: UniProt

UnificationXref299
type: UnificationXref
id: 4230113
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230113

UnificationXref298
type: UnificationXref
id: REACT_105917
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_105917.9

Phosphate
type: SmallMoleculeReference
name: Orthophosphate
name: Orthophosphate [ChEBI:18367]
name: Inorganic Phosphate
xref: UnificationXref184

UnificationXref295
type: UnificationXref
id: 4230365
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230365

UnificationXref294
type: UnificationXref
id: 4230112
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230112

UnificationXref297
type: UnificationXref
id: 4230366
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230366

UnificationXref296
type: UnificationXref
id: 4230364
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230364

UniProt:Q7A5G7
type: ProteinReference
xref: UnificationXref242
organism: BioSource1

UniProt:Q7A5G9
type: ProteinReference
xref: UnificationXref472
organism: BioSource1

http://identifiers.org/pubmed/11032841
type: PublicationXref
id: 11032841
author: Jaffe, EK
author: Martins, J
author: Volin, M
author: Mitchell, LW
db: Pubmed
title: Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase
source: J Biol Chem 276:1538-44
year: 2001

UnificationXref282
type: UnificationXref
id: REACT_79366
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_79366.9

UnificationXref281
type: UnificationXref
id: 4231257
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231257

UnificationXref280
type: UnificationXref
id: REACT_33224
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_33224.10

UnificationXref289
type: UnificationXref
id: CHEBI:17111
db: ChEBI

UnificationXref288
type: UnificationXref
id: REACT_3275
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3275.2

UnificationXref287
type: UnificationXref
id: 109386
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109386

UnificationXref286
type: UnificationXref
id: CHEBI:17713
db: ChEBI

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
type: Pathway
data source: Reactome
pathway component: Synthesis of substrates in N-glycan biosythesis
evidence: Evidence423
xref: RelationshipXref493
xref: UnificationXref2990
xref: UnificationXref2991
pathway order: PathwayStep412
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref285
type: UnificationXref
id: REACT_5673
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_5673.1

UnificationXref284
type: UnificationXref
id: 110644
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=110644

UnificationXref283
type: UnificationXref
id: CHEBI:16284
db: ChEBI

Ammonia
type: SmallMoleculeReference
name: NH3 [ChEBI:16134]
name: NH3
xref: UnificationXref1175

Hydrogen sulfide [ChEBI:5787]
type: SmallMoleculeReference
name: H2S
name: Hydrogen-sulfide
name: Hydrogen sulfide
xref: UnificationXref1950

UniProt:Q7A5V8
type: ProteinReference
xref: UnificationXref2878
organism: BioSource1

UniProt:Q7A5V7
type: ProteinReference
xref: UnificationXref402
organism: BioSource1

http://identifiers.org/pubmed/9278442
type: PublicationXref
id: 9278442
author: Shiba, K
author: Musier-Forsyth, K
author: Stello, T
author: Noda, T
author: Motegi, H
author: Schimmel, P
db: Pubmed
title: Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant
source: J Biol Chem 272:22809-16
year: 1997

sialic acid
type: SmallMolecule
entity reference: CHEBI:21622
data source: Reactome
xref: UnificationXref2686
xref: UnificationXref2685
cellular location: cytosol
comment: Reactome DB_ID: 428633
display name: SA

Acids transported by SMCT1
type: SmallMolecule
data source: Reactome
member physical entity: L-Lactic acid
member physical entity: Pyruvate
member physical entity: Butyrate
member physical entity: Acetate
member physical entity: Propanoic acid
xref: UnificationXref2710
xref: UnificationXref2711
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 429739

L-Lactic acid
type: SmallMolecule
entity reference: L-Lactic acid
data source: Reactome
name: L-Lactate
name: (S)-Lactate
xref: UnificationXref2698
xref: UnificationXref2699
cellular location: extracellular region
comment: Reactome DB_ID: 373863
display name: LACT

Acetate
type: SmallMolecule
entity reference: Acetate [ChEBI:15366]
data source: Reactome
name: Ethanoic acid
name: Acetic acid
xref: UnificationXref2700
xref: UnificationXref2701
cellular location: extracellular region
comment: Reactome DB_ID: 372540
display name: CH3COO-

UniProt:P63583
type: ProteinReference
xref: UnificationXref1809
organism: BioSource1

H+
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref2680
xref: UnificationXref2681
cellular location: lysosomal lumen
comment: Reactome DB_ID: 428040

sialic acid
type: SmallMolecule
entity reference: CHEBI:21622
data source: Reactome
xref: UnificationXref2684
xref: UnificationXref2683
cellular location: lysosomal lumen
comment: Reactome DB_ID: 428639
display name: SA

http://identifiers.org/pubmed/12967557
type: PublicationXref
id: 12967557
author: Veeman, Michael T
author: Moon, Randall T
author: Axelrod, Jeffrey D
db: Pubmed
title: A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
source: Dev. Cell 5:367-77
year: 2003

Butyrate
type: SmallMolecule
entity reference: CHEBI:30772
data source: Reactome
xref: UnificationXref2704
xref: UnificationXref2703
cellular location: extracellular region
comment: Reactome DB_ID: 429760
display name: BUT

Propanoic acid
type: SmallMolecule
entity reference: CHEBI:30768
data source: Reactome
name: EtCOO- or C2H5COO-
xref: UnificationXref2706
xref: UnificationXref2707
cellular location: extracellular region
comment: Reactome DB_ID: 429737
display name: Propionate

Pyruvate
type: SmallMolecule
entity reference: Pyruvate
data source: Reactome
name: Pyruvic acid
name: Pyroracemic acid
name: 2-Oxopropanoate
name: 2-Oxopropanoic acid
xref: UnificationXref2709
xref: UnificationXref2708
cellular location: extracellular region
comment: Reactome DB_ID: 429750
display name: PYR

Acids transported by SMCT1
type: SmallMolecule
data source: Reactome
member physical entity: Propanoic acid
member physical entity: Pyruvate
member physical entity: L-Lactic acid
member physical entity: Butyrate
member physical entity: SmallMolecule394
xref: UnificationXref2717
xref: UnificationXref2716
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 429748

http://identifiers.org/pubmed/12907679
type: PublicationXref
id: 12907679
author: Yau, King-Wai
author: Sun, Hui
author: Tsunenari, Takashi
author: Smallwood, Philip
author: Williams, J
author: Nathans, Jeremy
author: Cahill, Hugh
db: Pubmed
title: Structure-function analysis of the bestrophin family of anion channels
source: J. Biol. Chem. 278:41114-25
year: 2003

UniProt:Q7A664
type: ProteinReference
xref: UnificationXref2056
organism: BioSource1

UniProt:Q7A666
type: ProteinReference
xref: UnificationXref187
organism: BioSource1

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
type: SmallMoleculeReference
name: ChEBI:18381 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide
xref: UnificationXref973

inorganic sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Reactome
name: Sulphate
name: Sulfate
xref: UnificationXref2736
xref: UnificationXref2737
cellular location: cytosol
comment: Reactome DB_ID: 174375
display name: SO4(2-)

Dicarboxylates transported by NaDC1
type: SmallMolecule
data source: Reactome
member physical entity: Citrate
member physical entity: Ethylenesuccinic acid
xref: UnificationXref2750
xref: UnificationXref2751
cellular location: extracellular region
comment: Reactome DB_ID: 433111
comment: Converted from EntitySet in Reactome

taurolithocholate sulfate
type: SmallMolecule
entity reference: taurolithocholic acid sulfate
data source: Reactome
xref: UnificationXref2728
xref: UnificationXref2727
cellular location: cytosol
comment: Reactome DB_ID: 176483

inorganic sulfate
type: SmallMolecule
entity reference: Sulfate [ChEBI:16189]
data source: Reactome
name: Sulphate
xref: UnificationXref2735
xref: UnificationXref2734
cellular location: extracellular region
comment: Reactome DB_ID: 427648
display name: SO4(2-)

Propanoic acid
type: SmallMolecule
entity reference: CHEBI:30768
data source: Reactome
name: EtCOO- or C2H5COO-
xref: UnificationXref2714
xref: UnificationXref2715
cellular location: cytosol
comment: Reactome DB_ID: 429754
display name: Propionate

taurolithocholate sulfate
type: SmallMolecule
entity reference: taurolithocholic acid sulfate
data source: Reactome
xref: UnificationXref2725
xref: UnificationXref2726
cellular location: extracellular region
comment: Reactome DB_ID: 433120

http://identifiers.org/pubmed/16650285
type: PublicationXref
id: 16650285
author: Gorelick, DA
author: Agre, P
author: Tsunenari, T
author: Nielsen, S
author: Praetorius, J
db: Pubmed
title: Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
source: BMC Biochem 7:14
year: 2006

UniProt:P68779
type: ProteinReference
xref: UnificationXref1035
organism: BioSource1

Butyrate
type: SmallMolecule
entity reference: CHEBI:30772
data source: Reactome
xref: UnificationXref2713
xref: UnificationXref2712
cellular location: cytosol
comment: Reactome DB_ID: 76179
display name: BUT

Dicarboxylates transported by NaDC1
type: SmallMolecule
data source: Reactome
member physical entity: Ethylenesuccinic acid
member physical entity: Citrate
xref: UnificationXref2755
xref: UnificationXref2754
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 433124

Citrate
type: SmallMolecule
entity reference: CHEBI:30769
data source: Reactome
xref: UnificationXref2745
xref: UnificationXref2746
cellular location: extracellular region
comment: Reactome DB_ID: 433138
display name: CIT

Ethylenesuccinic acid
type: SmallMolecule
entity reference: Ethylenesuccinic acid
data source: Reactome
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref2749
xref: UnificationXref2748
cellular location: extracellular region
comment: Reactome DB_ID: 433123
display name: SUCCA

UniProt:Q7A5T2
type: ProteinReference
xref: UnificationXref1105
organism: BioSource1

http://identifiers.org/pubmed/11773613
type: PublicationXref
id: 11773613
author: Agre, P
author: Knepper, MA
author: Frøkiaer, J
author: Marples, D
author: Nielsen, S
author: Kwon, TH
db: Pubmed
title: Aquaporins in the kidney: from molecules to medicine
source: Physiol Rev 82:205-44
year: 2002

(S)-2,5-Diaminopentanoate
type: SmallMolecule
entity reference: (S)-2,5-Diaminopentanoate
data source: Reactome
name: (S)-2,5-Diaminopentanoic acid
name: (S)-2,5-diaminovaleric acid
name: L-Ornithine
xref: UnificationXref2640
xref: UnificationXref2641
cellular location: extracellular region
comment: Reactome DB_ID: 375800
display name: L-Orn

2-aminosuccinic acid
type: SmallMolecule
entity reference: CHEBI:17053
data source: Reactome
name: L-Aspartate
name: L-Aspartic acid
xref: UnificationXref2651
xref: UnificationXref2652
cellular location: extracellular region
comment: Reactome DB_ID: 351973
display name: L-Asp

D-Aspartic acid
type: SmallMolecule
entity reference: CHEBI:17364
data source: Reactome
name: D-Aspartate
xref: UnificationXref2655
xref: UnificationXref2654
cellular location: extracellular region
comment: Reactome DB_ID: 427953
display name: D-Asp

http://identifiers.org/pubmed/8855281
type: PublicationXref
id: 8855281
author: Lu, M
author: Verdijk, MA
author: Smith, BL
author: Agre, P
author: Jung, JS
author: Lee, MD
author: Deen, PM
author: Rijss, JP
author: Merkx, G
db: Pubmed
title: The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain
source: Proc Natl Acad Sci U S A 93:10908-12
year: 1996

ligands of SLC7A3
type: SmallMolecule
data source: Reactome
member physical entity: SmallMolecule496
member physical entity: SmallMolecule1
member physical entity: SmallMolecule346
xref: UnificationXref2644
xref: UnificationXref2645
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 375791

High-affinity glutamate transporter ligands
type: SmallMolecule
data source: Reactome
member physical entity: 2-aminosuccinic acid
member physical entity: SmallMolecule432
member physical entity: D-Aspartic acid
xref: UnificationXref2657
xref: UnificationXref2656
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 428027

Potassium
type: SmallMolecule
entity reference: K+
data source: Reactome
xref: UnificationXref2663
xref: UnificationXref2662
cellular location: extracellular region
comment: Reactome DB_ID: 74126
display name: K+

H+
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref2669
xref: UnificationXref2668
cellular location: GO:0008021
comment: Reactome DB_ID: 428548

High-affinity glutamate transporter ligands
type: SmallMolecule
data source: Reactome
member physical entity: L-Glutaminic acid
member physical entity: L-Aspartate
member physical entity: D-Aspartic acid
xref: UnificationXref2661
xref: UnificationXref2660
cellular location: cytosol
comment: Reactome DB_ID: 427997
comment: Converted from EntitySet in Reactome

D-Aspartic acid
type: SmallMolecule
entity reference: CHEBI:17364
data source: Reactome
name: D-Aspartate
xref: UnificationXref2659
xref: UnificationXref2658
cellular location: cytosol
comment: Reactome DB_ID: 428044
display name: D-Asp

http://identifiers.org/pubmed/20495089
type: PublicationXref
id: 20495089
author: Rahmanto, YS
author: Becker, EM
author: Richardson, DR
author: Huang, ML
author: Lane, DJ
author: Ponka, P
author: Sheftel, AD
author: Whitnall, M
db: Pubmed
title: Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
source: Proc Natl Acad Sci U S A 107:10775-82
year: 2010

http://identifiers.org/pubmed/15956068
type: PublicationXref
id: 15956068
author: Danpure, CJ
db: Pubmed
title: Primary hyperoxaluria: from gene defects to designer drugs?
source: Nephrol Dial Transplant 20:1525-9
year: 2005

L-Glutaminic acid
type: SmallMolecule
entity reference: CHEBI:16015
data source: Reactome
name: L-Glutamic acid
name: L-Glutamate
xref: UnificationXref2671
xref: UnificationXref2670
cellular location: GO:0008021
comment: Reactome DB_ID: 428614
display name: Glu

2'-deoxyadenosine 5'-diphosphate
type: SmallMoleculeReference
name: 2'-deoxyadenosine 5'-diphosphate [ChEBI:16174]
name: dADP
xref: UnificationXref1306

UnificationXref301
type: UnificationXref
id: REACT_86893
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_86893.9

UnificationXref300
type: UnificationXref
id: 4230115
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230115

UnificationXref306
type: UnificationXref
id: GO:0005576
db: GENE ONTOLOGY

UnificationXref307
type: UnificationXref
id: 109276
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276

UnificationXref308
type: UnificationXref
id: REACT_3225
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_3225.1

UnificationXref309
type: UnificationXref
id: CHEBI:17002
db: ChEBI

UnificationXref302
type: UnificationXref
id: 4231282
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231282

UnificationXref303
type: UnificationXref
id: REACT_31544
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_31544.10

UnificationXref304
type: UnificationXref
id: 4231254
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4231254

UnificationXref305
type: UnificationXref
id: REACT_77005
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_77005.9

UnificationXref312
type: UnificationXref
id: CHEBI:15904
db: ChEBI

UnificationXref311
type: UnificationXref
id: REACT_7527
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7527.2

UnificationXref310
type: UnificationXref
id: 171076
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171076

http://identifiers.org/pubmed/10198162
type: PublicationXref
id: 10198162
author: Tanaka, I
author: Okada, M
author: Kuromitsu, J
author: Oki, T
author: Yamazaki, K
db: Pubmed
title: cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse
source: Genomics 57:227-34
year: 1999

UnificationXref319
type: UnificationXref
id: 192431
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192431

UnificationXref317
type: UnificationXref
id: REACT_7360
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7360.2

UnificationXref318
type: UnificationXref
id: CHEBI:16359
db: ChEBI

UnificationXref315
type: UnificationXref
id: CHEBI:16113
db: ChEBI

UnificationXref316
type: UnificationXref
id: 171149
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=171149

UnificationXref313
type: UnificationXref
id: 174602
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174602

UnificationXref314
type: UnificationXref
id: REACT_7844
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7844.2

http://identifiers.org/pubmed/15505377
type: PublicationXref
id: 15505377
author: Verbeek, E
author: Smit, G P A
author: Mancini, G M S
author: Melis, D
author: Verheijen, F
author: Benedetti, A
author: Havelaar, A C
db: Pubmed
title: NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic
source: J. Inherit. Metab. Dis. 27:725-33
year: 2004

dGMP
type: SmallMoleculeReference
name: Deoxyguanylic acid
name: 2'-Deoxyguanosine 5'-phosphate
name: 2'-Deoxyguanosine 5'-monophosphate
name: dGMP [ChEBI:16192]
name: Deoxyguanosine monophosphate
xref: UnificationXref1284

UnificationXref321
type: UnificationXref
id: CHEBI:17687
db: ChEBI

Urea [ChEBI:16199]
type: SmallMoleculeReference
name: Carbamide
name: Urea
xref: UnificationXref1816

UnificationXref320
type: UnificationXref
id: REACT_9608
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9608.1

UnificationXref323
type: UnificationXref
id: REACT_9858
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9858.1

UnificationXref322
type: UnificationXref
id: 192464
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192464

UnificationXref324
type: UnificationXref
id: CHEBI:28865
db: ChEBI

UnificationXref325
type: UnificationXref
id: 192421
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192421

UnificationXref326
type: UnificationXref
id: REACT_9642
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9642.1

UnificationXref327
type: UnificationXref
id: CHEBI:16755
db: ChEBI

UnificationXref328
type: UnificationXref
id: 192442
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192442

UnificationXref329
type: UnificationXref
id: REACT_9736
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9736.1

http://identifiers.org/pubmed/18184586
type: PublicationXref
id: 18184586
author: Rudolph, MG
author: Gasow, K
author: Diederichsen, U
author: Wittmann, JG
author: Frey, A
author: Heinrich, D
db: Pubmed
title: Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
source: Structure 16:82-92
year: 2008

UniProt:Q7A605
type: ProteinReference
xref: UnificationXref1445
organism: BioSource1

UnificationXref330
type: UnificationXref
id: CHEBI:36274
db: ChEBI

Sulfate [ChEBI:16189]
type: SmallMoleculeReference
name: Sulfuric acid
name: Sulfate
xref: UnificationXref2733

UnificationXref334
type: UnificationXref
id: 192415
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192415

UnificationXref333
type: UnificationXref
id: CHEBI:9407
db: ChEBI

UnificationXref332
type: UnificationXref
id: REACT_9554
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9554.1

UnificationXref331
type: UnificationXref
id: 192473
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192473

UnificationXref337
type: UnificationXref
id: REACT_9533
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9533.2

UnificationXref338
type: UnificationXref
id: Q7A3P6
db: UniProt

UnificationXref335
type: UnificationXref
id: REACT_9794
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_9794.1

UnificationXref336
type: UnificationXref
id: 192483
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192483

UnificationXref339
type: UnificationXref
id: 4230505
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230505

http://identifiers.org/pubmed/15728426
type: PublicationXref
id: 15728426
author: Montell, Craig
db: Pubmed
title: The TRP superfamily of cation channels
source: Sci. STKE 2005:re3
year: 2005

http://identifiers.org/pubmed/11937636
type: PublicationXref
id: 11937636
author: Rodrigue, GR
author: Fitch, JP
author: Wilson DM, 3rd
author: Sokhansanj, BA
db: Pubmed
title: A quantitative model of human DNA base excision repair. I. Mechanistic insights
source: Nucleic Acids Res 30:1817-25
year: 2002

http://identifiers.org/pubmed/18029057
type: PublicationXref
id: 18029057
author: Zimmermann, H
db: Pubmed
title: ATP and acetylcholine, equal brethren
source: Neurochem Int 52:634-48
year: 2008

http://identifiers.org/pubmed/11734571
type: PublicationXref
id: 11734571
author: Zhang, Z
author: Ferdinandusse, S
author: Mooijer, PA
author: Denis, S
author: Spector, AA
author: Wanders, RJ
author: Reddy, JK
db: Pubmed
title: Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid
source: J Lipid Res 42:1987-95
year: 2001

http://identifiers.org/pubmed/17145306
type: PublicationXref
id: 17145306
author: Ploegh, HL
author: Loureiro, J
db: Pubmed
title: Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions
source: Adv Immunol 92:225-305
year: 2006

http://identifiers.org/pubmed/10801319
type: PublicationXref
id: 10801319
author: Holden, HM
author: Thoden, JB
author: Wohlers, TM
author: Fridovich-Keil, JL
db: Pubmed
title: Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase
source: Biochemistry 39:5691-701
year: 2000

http://identifiers.org/pubmed/8943353
type: PublicationXref
id: 8943353
author: Nevins, JR
author: Herendeen, DR
author: DeGregori, J
author: Leone, G
author: Ohtani, K
author: Kelly, TJ
db: Pubmed
title: Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
source: Mol Cell Biol 16:6977-84
year: 1996

http://identifiers.org/pubmed/15761154
type: PublicationXref
id: 15761154
author: Pack, M
author: Chang, H
author: Delamarre, L
author: Trombetta, ES
author: Mellman, I
db: Pubmed
title: Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
source: Science 307:1630-4
year: 2005

http://identifiers.org/pubmed/18048764
type: PublicationXref
id: 18048764
author: Eizirik, DL
author: Cnop, M
author: Cardozo, AK
db: Pubmed
title: The role for endoplasmic reticulum stress in diabetes mellitus
source: Endocr Rev 29:42-61
year: 2008

Urea synthesis
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction147
pathway component: BiochemicalReaction150
pathway component: BiochemicalReaction146
pathway component: BiochemicalReaction148
pathway component: BiochemicalReaction149
pathway component: BiochemicalReaction151
evidence: Evidence236
xref: UnificationXref1833
xref: UnificationXref1832
xref: RelationshipXref293
pathway order: PathwayStep229
pathway order: PathwayStep230
pathway order: PathwayStep231
pathway order: PathwayStep232
pathway order: PathwayStep227
pathway order: PathwayStep228
display name: Urea cycle
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

Mitochondrial tRNA aminoacylation
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction202
pathway component: BiochemicalReaction203
pathway component: BiochemicalReaction197
pathway component: BiochemicalReaction194
pathway component: BiochemicalReaction192
pathway component: BiochemicalReaction199
pathway component: BiochemicalReaction204
pathway component: BiochemicalReaction193
pathway component: BiochemicalReaction195
pathway component: BiochemicalReaction198
pathway component: BiochemicalReaction196
pathway component: BiochemicalReaction200
pathway component: BiochemicalReaction201
evidence: Evidence339
xref: RelationshipXref386
xref: UnificationXref2502
xref: UnificationXref2501
pathway order: PathwayStep322
pathway order: PathwayStep325
pathway order: PathwayStep327
pathway order: PathwayStep319
pathway order: PathwayStep320
pathway order: PathwayStep324
pathway order: PathwayStep326
pathway order: PathwayStep328
pathway order: PathwayStep330
pathway order: PathwayStep329
pathway order: PathwayStep321
pathway order: PathwayStep323
pathway order: PathwayStep318
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

http://identifiers.org/pubmed/15583024
type: PublicationXref
id: 15583024
author: Hales, DB
author: Payne, AH
db: Pubmed
title: Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
source: Endocr Rev 25:947-70
year: 2004

proton
type: SmallMolecule
entity reference: H+ [ChEBI:15378]
data source: Reactome
xref: UnificationXref2950
xref: UnificationXref2951
cellular location: sperm flagellum
comment: Reactome DB_ID: 2872447
display name: H+

Uric acid
type: SmallMolecule
entity reference: Urate [ChEBI:17775]
data source: Reactome
xref: UnificationXref2944
xref: UnificationXref2945
cellular location: extracellular region
comment: Reactome DB_ID: 429056
display name: Urate

Uric acid
type: SmallMolecule
entity reference: Urate [ChEBI:17775]
data source: Reactome
xref: UnificationXref2943
xref: UnificationXref2942
cellular location: cytosol
comment: Reactome DB_ID: 30034
display name: Urate

Sodium
type: SmallMolecule
entity reference: Na+
data source: Reactome
name: sodium ion
xref: UnificationXref2937
xref: UnificationXref2936
cellular location: endoplasmic reticulum lumen
comment: Reactome DB_ID: 2892454
display name: Na+

Phosphate
type: SmallMolecule
entity reference: Phosphate
data source: Reactome
name: Orthophosphate
xref: UnificationXref2934
xref: UnificationXref2935
cellular location: endoplasmic reticulum lumen
comment: Reactome DB_ID: 113551
display name: Pi

Copper
type: SmallMolecule
entity reference: cupric ion
data source: Reactome
xref: UnificationXref2927
xref: UnificationXref2926
cellular location: Golgi lumen
comment: Reactome DB_ID: 936901
display name: Cu2+

Copper
type: SmallMolecule
entity reference: cupric ion
data source: Reactome
xref: UnificationXref2921
xref: UnificationXref2920
cellular location: extracellular region
comment: Reactome DB_ID: 437295
display name: Cu2+

UniProt:Q7A5Z7
type: ProteinReference
xref: UnificationXref265
organism: BioSource1

Copper
type: SmallMolecule
entity reference: cupric ion
data source: Reactome
xref: UnificationXref2918
xref: UnificationXref2919
cellular location: cytosol
comment: Reactome DB_ID: 209799
display name: Cu2+

D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: D-Glucosamine 6-phosphate [ChEBI:4164]
data source: Reactome
xref: UnificationXref2966
xref: UnificationXref2967
cellular location: cytosol
comment: Reactome DB_ID: 449701
display name: GlcN6P

UnificationXref2397
type: UnificationXref
id: CHEBI:29169
db: ChEBI

http://identifiers.org/pubmed/8434121
type: PublicationXref
id: 8434121
author: Mitra, S
author: Kaina, B
db: Pubmed
title: Regulation of repair of alkylation damage in mammalian genomes.
source: Prog Nucleic Acid Res Mol Biol 44:109-42
year: 1993

N-Acetyl-D-glucosamine 1-phosphate
type: SmallMolecule
entity reference: CHEBI:7125
data source: Reactome
xref: UnificationXref2975
xref: UnificationXref2976
cellular location: cytosol
comment: Reactome DB_ID: 532204
display name: AcGlcN1P

UnificationXref2398
type: UnificationXref
id: 379788
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379788

UnificationXref2399
type: UnificationXref
id: REACT_17073
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17073.1

Sodium
type: SmallMolecule
entity reference: Na+
data source: Reactome
name: sodium ion
xref: UnificationXref2953
xref: UnificationXref2952
cellular location: sperm flagellum
comment: Reactome DB_ID: 2872443
display name: Na+

UnificationXref2393
type: UnificationXref
id: P67509
db: UniProt

UnificationXref2394
type: UnificationXref
id: 4230700
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230700

Synthesis of PC
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction37
pathway component: BiochemicalReaction36
evidence: Evidence68
xref: RelationshipXref78
xref: UnificationXref530
xref: UnificationXref529
pathway order: PathwayStep64
pathway order: PathwayStep63
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2395
type: UnificationXref
id: 4230702
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230702

UnificationXref2396
type: UnificationXref
id: REACT_88047
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_88047.9

http://identifiers.org/pubmed/9706223
type: PublicationXref
id: 9706223
author: Kerner, J
author: Hoppel, C
db: Pubmed
title: Genetic disorders of carnitine metabolism and their nutritional management.
source: Annu Rev Nutr 18:179-206
year: 1998

UniProt:Q7A5Y3
type: ProteinReference
xref: UnificationXref2457
organism: BioSource1

2,4(1H,3H)-Pyrimidinedione, dihydro-
type: SmallMolecule
entity reference: CHEBI:15901
data source: Reactome
name: Dihydrouracile
name: 5,6-Dihydrouracil
name: 5,6-Dihydro-2,4-dihydroxypyrimidine
name: dihydrouracil
xref: UnificationXref3123
xref: UnificationXref3124
cellular location: nucleoplasm
comment: Reactome DB_ID: 30140
display name: Hydrouracil

UnificationXref2392
type: UnificationXref
id: REACT_16053
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16053.1

Purine-6-ol
type: SmallMolecule
entity reference: CHEBI:17368
data source: Reactome
name: Hypoxanthine
xref: UnificationXref3087
xref: UnificationXref3088
cellular location: nucleoplasm
comment: Reactome DB_ID: 29850
display name: Hyp

UnificationXref2391
type: UnificationXref
id: 379769
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379769

UnificationXref2390
type: UnificationXref
id: CHEBI:29160
db: ChEBI

formamidopyrimidine
type: SmallMolecule
entity reference: formamidopyrimidine
data source: Reactome
xref: UnificationXref3129
xref: UnificationXref3128
cellular location: nucleoplasm
comment: Reactome DB_ID: 110228
display name: FAPY

8-oxoguanine
type: SmallMolecule
entity reference: 8-oxoguanine [ChEBI:29116]
data source: Reactome
xref: UnificationXref3071
xref: UnificationXref3070
cellular location: nucleoplasm
comment: Reactome DB_ID: 110242
display name: OGUA

UDP-N-acetylglucosamine
type: SmallMolecule
entity reference: CHEBI:16264
data source: Reactome
name: UDP-N-acetyl-D-glucosamine
xref: UnificationXref2978
xref: UnificationXref2979
cellular location: cytosol
comment: Reactome DB_ID: 162756
display name: UDP-AcGlcN

ethenoadenine
type: SmallMolecule
entity reference: ethenoadenine
data source: Reactome
xref: UnificationXref3083
xref: UnificationXref3084
cellular location: nucleoplasm
comment: Reactome DB_ID: 110249
display name: EtAD

3-Methyladenine
type: SmallMolecule
entity reference: CHEBI:38635
data source: Reactome
xref: UnificationXref3078
xref: UnificationXref3079
cellular location: nucleoplasm
comment: Reactome DB_ID: 30947
display name: MADE

UnificationXref2388
type: UnificationXref
id: 113537
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113537

UnificationXref2389
type: UnificationXref
id: REACT_4106
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4106.2

UnificationXref2386
type: UnificationXref
id: REACT_15750
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15750.1

UnificationXref2387
type: UnificationXref
id: CHEBI:17191
db: ChEBI

UnificationXref2384
type: UnificationXref
id: CHEBI:29174
db: ChEBI

UnificationXref2385
type: UnificationXref
id: 379750
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379750

UnificationXref2382
type: UnificationXref
id: 4230754
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230754

UnificationXref2383
type: UnificationXref
id: REACT_80661
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_80661.9

http://identifiers.org/pubmed/16476485
type: PublicationXref
id: 16476485
author: Wahli, W
author: Gelman, L
author: Feige, JN
author: Desvergne, B
author: Michalik, L
db: Pubmed
title: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
source: Prog Lipid Res 45:120-59
year: 2006

Lipoate
type: SmallMolecule
entity reference: Lipoate
data source: Reactome
name: Lipoic acid
xref: UnificationXref2821
xref: UnificationXref2822
cellular location: extracellular region
comment: Reactome DB_ID: 429590
display name: LIPA

vitamins transported by SMVT
type: SmallMolecule
data source: Reactome
member physical entity: Coenzyme R
member physical entity: Pantothenate
member physical entity: Lipoate
xref: UnificationXref2824
xref: UnificationXref2823
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 429605

zinc
type: SmallMolecule
entity reference: Zinc [ChEBI:29105]
data source: Reactome
name: Zn(II)
name: Zn++
xref: UnificationXref2783
xref: UnificationXref2782
cellular location: GO:0008021
comment: Reactome DB_ID: 437093
display name: Zn2+

Zn(II)
type: SmallMolecule
entity reference: Zinc [ChEBI:29105]
data source: Reactome
name: Zn++
name: Zinc ion
xref: UnificationXref2774
xref: UnificationXref2773
cellular location: endosome lumen
comment: Reactome DB_ID: 435350
display name: Zn2+

iron (ferrous)
type: SmallMolecule
entity reference: CHEBI:18248
data source: Reactome
name: Fe(II)
name: Fe++
xref: UnificationXref2768
xref: UnificationXref2767
cellular location: extracellular region
comment: Reactome DB_ID: 435347
display name: Fe2+

Ethylenesuccinic acid
type: SmallMolecule
entity reference: Ethylenesuccinic acid
data source: Reactome
name: Butanedionic acid
name: Succinate
name: Succinic acid
xref: UnificationXref2752
xref: UnificationXref2753
cellular location: cytosol
comment: Reactome DB_ID: 29434
display name: SUCCA

Urea
type: SmallMolecule
entity reference: Urea [ChEBI:16199]
data source: Reactome
xref: UnificationXref2811
xref: UnificationXref2810
cellular location: extracellular region
comment: Reactome DB_ID: 432019

Chloride
type: SmallMolecule
entity reference: Chloride [ChEBI:17996]
data source: Reactome
xref: UnificationXref2807
xref: UnificationXref2806
cellular location: cytosol
comment: Reactome DB_ID: 352022
display name: Cl-

http://identifiers.org/pubmed/8342042
type: PublicationXref
id: 8342042
author: Hämmerling, GJ
author: Momburg, F
author: Neefjes, JJ
db: Pubmed
title: Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
source: Science 261:769-71
year: 1993

Chloride
type: SmallMolecule
entity reference: Chloride [ChEBI:17996]
data source: Reactome
xref: UnificationXref2804
xref: UnificationXref2805
cellular location: extracellular region
comment: Reactome DB_ID: 188972
display name: Cl-

UnificationXref2381
type: UnificationXref
id: 4230752
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230752

Zinc 2+
type: SmallMolecule
entity reference: Zinc [ChEBI:29105]
data source: Reactome
xref: UnificationXref2791
xref: UnificationXref2790
cellular location: GO:0034774
comment: Reactome DB_ID: 216785
display name: Zn2+

UnificationXref2380
type: UnificationXref
id: 4230751
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230751

UnificationXref2371
type: UnificationXref
id: 4230720
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230720

UnificationXref2372
type: UnificationXref
id: 4230722
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230722

UnificationXref2373
type: UnificationXref
id: REACT_32233
db: Reactome
id version: 10
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_32233.10

UnificationXref2374
type: UnificationXref
id: 379770
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379770

UniProt:Q7A697
type: ProteinReference
xref: UnificationXref1532
organism: BioSource1

UnificationXref2375
type: UnificationXref
id: REACT_16111
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16111.1

vitamins transported by SMVT
type: SmallMolecule
data source: Reactome
member physical entity: Coenzyme R
member physical entity: Lipoate
member physical entity: Pantothenate
xref: UnificationXref2827
xref: UnificationXref2828
cellular location: cytosol
comment: Reactome DB_ID: 429627
comment: Converted from EntitySet in Reactome

UnificationXref2376
type: UnificationXref
id: 159549
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159549

UnificationXref2377
type: UnificationXref
id: REACT_7329
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_7329.2

UnificationXref2378
type: UnificationXref
id: 379781
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379781

http://identifiers.org/pubmed/9405233
type: PublicationXref
id: 9405233
author: Ishida, N
author: Mita, S
author: Ohno, I
author: Kawamoto, S
author: Matsuzawa, Y
author: Okubo, K
author: Matsubara, K
author: Kuriyama, H
db: Pubmed
title: Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability
source: Biochem Biophys Res Commun 241:53-8
year: 1997

UnificationXref2379
type: UnificationXref
id: REACT_15734
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15734.1

cholest-5-en-3beta-ol
type: SmallMoleculeReference
name: cholesterol
name: cholesterol [ChEBI:16113]
xref: UnificationXref315

inosine
type: SmallMolecule
entity reference: CHEBI:17596
data source: Reactome
xref: UnificationXref2852
xref: UnificationXref2853
cellular location: cytosol
comment: Reactome DB_ID: 83927
display name: Ino

Dihydroxyacetone phosphate
type: SmallMoleculeReference
name: Glycerone phosphate
name: Dihydroxyacetone phosphate [ChEBI:16108]
xref: UnificationXref105

ligands of SLC28A1
type: SmallMolecule
data source: Reactome
member physical entity: uridine
member physical entity: Adenosine
member physical entity: thymidine
member physical entity: cytidine
member physical entity: 2'-deoxyadenosine
xref: UnificationXref2831
xref: UnificationXref2832
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 179738

Lipoate
type: SmallMolecule
entity reference: Lipoate
data source: Reactome
name: Lipoic acid
xref: UnificationXref2826
xref: UnificationXref2825
cellular location: cytosol
comment: Reactome DB_ID: 429608
display name: LIPA

2'-deoxyadenosine
type: SmallMolecule
entity reference: CHEBI:17256
data source: Reactome
name: deoxyadenosine
xref: UnificationXref2834
xref: UnificationXref2833
cellular location: cytosol
comment: Reactome DB_ID: 83925
display name: dA

http://identifiers.org/pubmed/1748670
type: PublicationXref
id: 1748670
author: Gozes, Y
author: Grosfeld, H
author: Velan, B
author: Leitner, M
author: Lazar, A
author: Kronman, C
author: Marcus, D
author: Flashner, Y
author: Shafferman, A
author: Cohen, S
db: Pubmed
title: The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant
source: J Biol Chem 266:23977-84
year: 1991

ligands of SLC28A1
type: SmallMolecule
data source: Reactome
member physical entity: cytidine
member physical entity: Deoxythymidine
member physical entity: adenosine
member physical entity: 2'-deoxyadenosine
member physical entity: uridine
xref: UnificationXref2837
xref: UnificationXref2838
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 179739

ligands of SLC29A1
type: SmallMolecule
data source: Reactome
member physical entity: uridine
member physical entity: guanosine
member physical entity: Adenosine
member physical entity: inosine
member physical entity: thymidine
member physical entity: cytidine
xref: UnificationXref2848
xref: UnificationXref2849
cellular location: extracellular region
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 179745

UnificationXref2370
type: UnificationXref
id: P99170
db: UniProt

adenosine
type: SmallMolecule
entity reference: adenosine
data source: Reactome
name: ADENOCARD (TN)
xref: UnificationXref2836
xref: UnificationXref2835
cellular location: cytosol
comment: Reactome DB_ID: 83909
display name: Ade-Rib

Purine salvage
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction79
pathway component: BiochemicalReaction80
pathway component: BiochemicalReaction78
evidence: Evidence139
xref: UnificationXref1055
xref: RelationshipXref163
xref: UnificationXref1056
pathway order: PathwayStep133
pathway order: PathwayStep135
pathway order: PathwayStep134
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

guanosine
type: SmallMolecule
entity reference: Guanosine
data source: Reactome
xref: UnificationXref2851
xref: UnificationXref2850
cellular location: cytosol
comment: Reactome DB_ID: 83926
display name: Gua-Rib

8-oxoguanine [ChEBI:29116]
type: SmallMoleculeReference
name: 8-oxoguanine
xref: UnificationXref3069

ligands of SLC28A3
type: SmallMolecule
data source: Reactome
member physical entity: guanosine
member physical entity: cytidine
member physical entity: Deoxythymidine
member physical entity: adenosine
member physical entity: uridine
member physical entity: inosine
xref: UnificationXref2854
xref: UnificationXref2855
cellular location: cytosol
comment: Converted from EntitySet in Reactome
comment: Reactome DB_ID: 179743

UnificationXref2362
type: UnificationXref
id: 4230738
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230738

UnificationXref2363
type: UnificationXref
id: REACT_110506
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_110506.9

http://identifiers.org/pubmed/7530250
type: PublicationXref
id: 7530250
author: Agre, P
author: Guggino, WB
author: Preston, GM
author: Raina, S
db: Pubmed
title: Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues
source: J Biol Chem 270:1908-12
year: 1995

UnificationXref2360
type: UnificationXref
id: 4230735
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230735

UnificationXref2361
type: UnificationXref
id: 4230736
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230736

UnificationXref2366
type: UnificationXref
id: REACT_15650
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15650.1

UnificationXref2367
type: UnificationXref
id: CHEBI:29157
db: ChEBI

ligands of SLC28A2
type: SmallMolecule
data source: Reactome
member physical entity: uridine
member physical entity: guanosine
member physical entity: Adenosine
member physical entity: inosine
xref: UnificationXref2863
xref: UnificationXref2862
cellular location: extracellular region
comment: Reactome DB_ID: 179740
comment: Converted from EntitySet in Reactome

UnificationXref2364
type: UnificationXref
id: CHEBI:29175
db: ChEBI

ligands of SLC28A2
type: SmallMolecule
data source: Reactome
member physical entity: guanosine
member physical entity: adenosine
member physical entity: uridine
member physical entity: inosine
xref: UnificationXref2865
xref: UnificationXref2864
cellular location: cytosol
comment: Reactome DB_ID: 179741
comment: Converted from EntitySet in Reactome

UnificationXref2365
type: UnificationXref
id: 379754
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379754

UnificationXref2368
type: UnificationXref
id: 379744
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379744

UnificationXref2369
type: UnificationXref
id: REACT_15607
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_15607.1

UnificationXref2442
type: UnificationXref
id: 379789
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379789

UnificationXref2441
type: UnificationXref
id: CHEBI:29153
db: ChEBI

UnificationXref2444
type: UnificationXref
id: P68848
db: UniProt

Cleavage of the damaged pyrimidine
type: Pathway
data source: Reactome
pathway component: BiochemicalReaction276
pathway component: BiochemicalReaction275
pathway component: BiochemicalReaction277
pathway component: BiochemicalReaction274
evidence: Evidence468
xref: UnificationXref3132
xref: UnificationXref3133
xref: RelationshipXref511
pathway order: PathwayStep449
pathway order: PathwayStep448
pathway order: PathwayStep451
pathway order: PathwayStep450
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2443
type: UnificationXref
id: REACT_16119
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_16119.1

SequenceSite99
type: SequenceSite
position status: EQUAL
sequence position: 327

SequenceSite98
type: SequenceSite
position status: EQUAL
sequence position: 50

UnificationXref2440
type: UnificationXref
id: REACT_17466
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_17466.1

SequenceSite97
type: SequenceSite
position status: EQUAL
sequence position: 415

SequenceSite96
type: SequenceSite
position status: EQUAL
sequence position: 1

UnificationXref2449
type: UnificationXref
id: 379775
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379775

UnificationXref2446
type: UnificationXref
id: 4230717
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230717

UnificationXref2445
type: UnificationXref
id: 4230715
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230715

UnificationXref2448
type: UnificationXref
id: CHEBI:29177
db: ChEBI

http://identifiers.org/pubmed/2537655
type: PublicationXref
id: 2537655
author: Tatibana, M
author: Yamada, K
author: Shimada, H
author: Iizasa, T
author: Taira, M
db: Pubmed
title: Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testic-specific transcript
source: Biochim Biophys Acta 1007:203-208
year: 1989

UnificationXref2447
type: UnificationXref
id: REACT_129750
db: Reactome
id version: 5
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_129750.5

Visual phototransduction
type: Pathway
data source: Reactome
pathway component: The retinoid cycle in cones (daylight vision)
evidence: Evidence304
xref: UnificationXref2252
xref: RelationshipXref367
xref: UnificationXref2251
pathway order: PathwayStep298
comment: This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.
organism: BioSource1

UnificationXref2455
type: UnificationXref
id: 379745
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379745

UnificationXref2454
type: UnificationXref
id: CHEBI:29154
db: ChEBI

UnificationXref2453
type: UnificationXref
id: REACT_21629
db: Reactome
id version: 2
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21629.2

UnificationXref2452
type: UnificationXref
id: 379717
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379717

UnificationXref2451
type: UnificationXref
id: CHEBI:17203
db: ChEBI

UnificationXref2450
type: UnificationXref
id: REACT_22591
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_22591.1

UnificationXref2459
type: UnificationXref
id: 4230707
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230707

UnificationXref2458
type: UnificationXref
id: 4230705
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=4230705

UnificationXref2457
type: UnificationXref
id: Q7A5Y3
db: UniProt

UnificationXref2456
type: UnificationXref
id: REACT_23357
db: Reactome
id version: 1
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_23357.1

UniProt:Q7A4A4
type: ProteinReference
xref: UnificationXref2980
organism: BioSource1

UnificationXref2460
type: UnificationXref
id: REACT_83595
db: Reactome
id version: 9
comment: Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_83595.9

UnificationXref190
type: UnificationXref
id: 29582
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29582

UnificationXref2462
type: UnificationXref
id: 379761
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=379761

UnificationXref2461
type: UnificationXref
id: CHEBI:29179
db: ChEBI

UnificationXref2464
type: UnificationXref
id: CHEBI:17115
db: ChEBI

UnificationXref193
type: UnificationXref
id: 113527
db: Reactome Database ID Release 45
comment: Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113527